Kornimate/medical-research-clean huggingface dataset:
reconstruction of extensive upper extremity long bone defects with a microvascular fibula flap

Conditions: Limb Salvage

Summary: this study assesses the long-term functional outcomes of upper extremity long bone defects treated with the free fibula bone transfer.

the study design entails a retrospective review of hospital records and a cross-sectional assessment using patient-reported outcome measures. the purpose of this study is to evaluate the reliability, complications and flap survival rate as well as the long-term functional and health-related quality of life results in patients with upper extremity long bone defect reconstructed using a microvascular fibula bone transfer.

Eligibility criteria:
inclusion criteria: * all patients of upper extremity long bone bone defect treated with a microvascular fibula transfer in helsinki university central hospital. exclusion criteria: * no upper extremity free fibular transfer
structured exercise training program versus hypocaloric hyperproteic diet in obese anovulatory infertile patients with pcos

Conditions: Polycystic Ovary Syndrome; Anovulation; Infertility

Summary: lifestyle modifications are successfully employed in polycystic ovarian syndrome (pcos) improving menstrual cycles and fertility. unfortunately, the compliance over the time is very low. recently, we have showed a high adherence to structured exercise training (set) program in women with pcos. the current study will be aimed to compare the efficacy of the set program with a diet program on the reproductive function in obese anovulatory infertile pcos patients.

forty obese anovulatory infertile pcos patients who wish to conceive will be allocated in two study-groups according to their desire: structured exercise training (set) group (n. 20) will undergo a set program, whereas diet group (n. 20) will undertake a hypocaloric hyperproteic diet. the duration of the study will be of 24 weeks. at baseline, after 12 and 24 weeks clinical, endocrine and metabolic evaluations will be performed in each patient and all reproductive events obtained throughout the study will be recorded.

Eligibility criteria:
inclusion criteria: * pcos * anovulatory infertility * obesity (bmi \>30) exclusion criteria: * age \ 35 years * neoplastic, metabolic, hepatic, renal, and cardiovascular disorders or other concurrent medical illnesses * hypothyroidism, hyperprolactinemia, cushing's syndrome, and non-classical congenital adrenal hyperplasia * current or previous (within the last six months) use of oral contraceptives, glucocorticoids, antiandrogens, ovulation induction agents, antidiabetic and anti-obesity drugs or other drugs know to affect sex hormone levels, carbohydrate metabolism, or appetite * organic pelvic diseases, previous pelvic surgery, suspected peritoneal factor infertility, tubal or male factor infertility or sub-fertility

Keywords: structured exercise training program infertility menstrual cycle pcos treatment
the effect of a low-calorie diet with balanced nutrition on metabolic syndrome

Conditions: Metabolic Syndrome, Protection Against

Summary: the study looked at how a nutritionally balanced low-calorie diet based on traditional indonesian foods affected obese people's metabolic biomarkers. the traditional indonesian foods presented here are minangkabau cuisine. body mass index, waist circumference, systolic and diastolic blood pressure, body fat mass percentage, fasting blood sugar levels, and lipid profiles are among the metabolic biomarkers measured. the provision of a balanced nutritionally low-calorie diet based on traditional indonesian foods, according to the researchers, will have a significant effect on the metabolic biomarkers of obese people.

the research was carried out at rsup dr. m. djamil padang. the research ethics commission of andalas university's faculty of medicine granted the study an ethical permit. health workers with a bmi of more than 25 kg/m2 became the study population, and officers who agreed to participate in the study after filling out the informed consent form were included in the study. there were 91 people in the study. the study lasted eight weeks (56 days). a week before the study, participants were interviewed about their daily intake using 24-hour food recall, and anthropometric measurements were taken using calibrated tools and performed by trained officers. subjects underwent a one-week pre-treatment period (baseline period, beginning on d-day 6 and ending on d-day 0), during which they were asked not to take any supplements. all participants had their anthropometric measurement, blood pressure, body fat percentage, fasting blood sugar levels, and lipid profile checked on day 0 and day 57. the nutrisurvey 2005 application was used to process the daily intake of participants obtained from a 24-hour food recall interview. dietary interventions were given with a calorie deficit of 500-600 kcal from the participants' usual daily intake. a minangkabau food menu is provided as part of the diet. participants are given a list of daily menus, which include breakfast, lunch, and dinner. researchers provided lunch for study participants, while breakfast and dinner were prepared independently by participants using the dietary guidelines and menus provided. participants kept a food diary, which was collected and evaluated twice a week. the research team also controls and motivates all participants via whatsapp groups. the study's findings were analyzed using the spss software.

Eligibility criteria:
inclusion criteria: * employee of rsup dr. m. djamil, padang who suffers from obesity (bmi ≥ 25 kg / m2) * willing to follow the research by signing an informed concent exclusion criteria: * did not come and could not be found at the time of research data collection * unable to follow the dietary arrangements as set * taking anti-diabetic or anti-lipid drugs * use of contraceptives or hormonal drugs * in the treatment of radiotherapy or chemotherapyi

Keywords: nutritionally balanced low-calorie diet archipelago diet metabolic biomarkers
plasma triglyceride lipolysis in multifactorial chylomicronemia

Conditions: Hyperlipoproteinemia

Summary: purpose: the mechanism of most of the multifactorial chylomicronemia (mcm) remains elusive. in order to decipher the mechanisms involved in the occurrence of this disease, plasma tg lipolysis characteristics will be monitored for 60 minutes after heparin injection instead of the 10 minutes gold standard, in a large group of genotyped mcm patients.

purpose: the mechanism of most of the multifactorial chylomicronemia (mcm) remains elusive. in order to decipher the mechanisms involved in the occurrence of this disease, plasma tg lipolysis characteristics will be monitored for 60 minutes after heparin injection instead of the 10 minutes gold standard, in a large group of genotyped mcm patients. method: lpl, apoc2, apoa5, gpihb1and apoe genotypes will be determined for each patient. basal lipid profiles including apo b, cii, ciii, and lipoprotein lipase (lpl) concentration will be measured in 62 mcm patients, in addition to lpl activity (phla) t0, t10 t30 t60 minutes, assessment of tg chylomicron decrease study of lipoprotein remodelling by agarose gel electrophoresis. hypothesis to confirm the preliminary finding of high lpl activity in multifactorial chylomicronemia to explore the interest of a longer assessment of lpl activity following heparin injection. to establish if specific phenotypes could be identified among mcm patient supporting the hypothesis of different mechanisms involved (ie overproduction or defect in hepatic clearance)

Eligibility criteria:
inclusion criteria: * patient with a documented history of mcm (plasma tg concentration (tg) \> 15 mmol/l or familial history of hypertriglyceridemia with tg \>10 mmol/l) * no contraindication for a single heparin injection for ex vivo lpl activity assessment exclusion criteria: * patients carriers of homozygous or compound heterozygous mutations on lpl, gpihbp1, apoa5, apoc2 or apoe genes

Keywords: lipoprotein lipase hypertriglyceridemia triglycerides lipolysis multifactorial chylomicronemia
a study of the safety and efficacy of anacetrapib (mk-0859) when added to ongoing statin therapy in japanese participants with heterozygous familial hypercholesterolemia (mk-0859-050)

Conditions: Heterozygous Familial Hypercholesterolemia (HeFH)

Summary: this study will evaluate the effects of anacetrapib (mk-0859) on low-density lipoprotein-cholesterol (ldl-c) when compared to placebo in japanese participants with heterozygous familial hypercholesterolemia when added to an existing statin lipid-modifying therapy.


Eligibility criteria:
inclusion criteria: * if female, cannot be of reproductive potential * diagnosed with heterozygous familial hypercholesterolemia * have been treated with an appropriate and stable dose of statin± other lipid-lowering medication(s) for at least 6 weeks exclusion criteria: * previously participated in a study with a cholesteryl ester transfer protein (cetp) inhibitor * homozygous familial hypercholesterolemia * severe chronic heart failure * uncontrolled cardiac arrhythmias, myocardial infarction (mi), percutaneous coronary intervention (pci), coronary artery by-pass graft (cabg), unstable angina, or stroke within 3 months
a 5 year follow-up on newly diagnosed breast cancer patients

Conditions: Newly Diagnosed Breast Cancer

Summary: the purpose of this study is to provide the physicians with quality long term follow up data on subjects from the breast cancer clinic and the plastic surgery clinic who have been newly diagnosed with breast cancer and will receive treatment for the cancer at this facility. over the last two decades many studies have been done concerning the quality of life after a mastectomy and/or reconstruction process. the majority of these studies only run for one year post reconstruction, some however, do include a two year follow up. the investigators are proposing a 5 year long term follow up study on subjects who will be diagnosed and treated here at the breast cancer clinic and the plastic surgery clinic. the investigators first questionnaire will be given prior to any treatment for breast cancer, giving us a baseline for the subject's current quality of life. at each successive year, the subject will be given another questionnaire with regards to their progression through the reconstructive process. at the end of 5 years, the subject will complete a final questionnaire. these questionnaires will deal with many areas of daily life functions; activities of daily living, anxiety, depression, social interactions, personal and sexual relationships.

upon informed consent of subject, a baseline questionnaire will be completed by the subject. at years 1, 2, 3, and 4 follow up questionnaires will be sent for completion to the subject. at year 5 a final questionnaire will be sent to the subject for completion.after all subjects have completed the study, data will be sent to the department of biostatics for analysis.

Eligibility criteria:
inclusion criteria: any female age 18 or over that has been diagnosed with breast cancer and has been treated and followed in the breast cancer clinic and the plastic surgery clinic is eligible for study participation. exclusion criteria: any person not meeting these requirements will not be eligible for study participation.

Keywords: breast cancer quality of life survey
hemophagocytosis in critically ill adult patients

Conditions: Hemophagocytosis

Summary: the purpose of the study is to find out whether non-responsiveness to therapeutic recombinant human granulocyte colony-stimulation factor (rhg-csf) is associated with hemophagocytosis in critically ill adult patients with cytopenias.

in children with bi- or pancytopenia, hemophagocytosis is known as life-threatening hemophagocytic lymphohistiocytosis (hlh). the purpose of the study is to find out whether adult patients with bicytopenia or pancytopenia fulfilling the clinical hlh criteria used in children reflect life-threatening hemophagocytosis and whether hemophagocytosis is associated with responsiveness to recombinant human granulocyte colony-stimulation factor (rhg-csf) or not.

Eligibility criteria:
inclusion criteria: * age \> 18 years * critically ill adult patients * leukopenia and thrombocytopenia * rhg-csf therapy exclusion criteria: * life expectancy \< 24 hours * inclusion in other studies * trauma patients with reanimation on scene or immediately dying on hospital admission * pregnancy * hematologic disorder, malignancy * high dose corticosteroid treatment or chemotherapy

Keywords: hemophagocytosis, adults, rhg-csf
imas optimization and applicability in an acute stroke setting.

Conditions: Acute Stroke

Summary: the investigator will investigate our integrated sensor-based motion analysis suite (imas) to objectively and quantitatively measure acute stroke patient motor status.

the investigator will evaluate the feasibility of our imas to assess 30 stroke subjects in 5 sessions (the first 4 proximal to stroke onset and the last session \~6-8 weeks post stroke). the investigator will test imas in 30 acute stroke subjects; and extract quantitative movement kinematic/kinetic metrics descriptive of subjects' motor behavior (e.g., arm movement speed, smoothness). subjects will undergo a series of upper limb focused assessments including fugl meyer, barthel index, and orpington prognostic scale assessments. the investigator will also collect demographics, and stroke clinical information such as imaging data.

Eligibility criteria:
inclusion criteria: 1. providing informed consent to participate in the study. 2. age 18 to 85 years old. 3. clinical presentation and neuroimaging (cta-ctp/ mri-mra) consistent with the diagnosis of acute ischemic or hemorrhagic stroke. 4. preserved mental status (glasgow coma score \>12: e(4), v(5), m (4-6)). 5. presence of upper limb weakness per the nihss (1-2 points in the arm) and ability to perform testing (i.e. nihss motor score 1-2 at elbow, wrist, and finger flexion extension). (note that individuals with a prior ischemic or hemorrhagic stroke with available information pertaining superior extremity baseline strength after their previous stroke would qualify). 6. baseline modified rankin score \<4. exclusion criteria: 1. history of alcohol or drug abuse within the past 6 months as self-reported; 2. history of schizophrenia, schizoaffective disorder, other psychosis, bipolar illness, alcohol/drug abuse within the past year; 3. need for rapid clinical response due to conditions such as initiation, psychosis, or suicidality; 4. unstable medical conditions (e.g. uncontrolled diabetes, uncompensated cardiac issues, heart failure, pulmonary issues, or chronic obstructive pulmonary disease); 5. history of dementia per relative/ medical records. 6. presence of receptive aphasia at baseline or after the current acute stroke. 7. amputated limbs. 8. absence of weakness as per the nihss (0 points = no drift for motor arm and leg items) or severe motor impairment nihss 4 points for motor arm). 9. stroke mimics (e.g., infections, medication effects from sedatives, electrolyte imbalances, etc.). 10. stroke worsening between assessments.

Keywords: stroke rehabilitation motor recovery
the effects of intermittent hypoxia on acute hypoxic injury

Conditions: Acute Mountain Sickness

Summary: this study intends to further reveal the effectiveness of intermittent hypoxia in preventing acute hypoxic injury.

acute exposure to hypoxia can induce acute hypoxic injury (ahi), according to the severity of the injury, it can be divided into acute mountain sickness (ams), high altitude pulmonary edema (hape) and high altitude cerebral edema (hace). ams is the most common type, it mostly occurs within 6-12 hours after rapidly entering the altitude above 2500m, sometimes within 1h, and can be manifested as headache, nausea, diarrhea, sleep disorders, etc. the incidence of ams at the altitude of 2500-3000m is 10-20%, which reaches 50-85% at 4500-5000m above sea level. intermittent hypoxia (ih) refers to periodic hypoxic-normoxic training performed with brief exposure to hypoxia. previous studies have found that short-term intermittent hypoxia can increase the sensitivity of hypoxia and reduce the severity of acute hypoxia injury, and alleviate acute hypoxia injury by reducing the inflammatory response caused by hypoxia. therefore, this study aims to conduct a randomized controlled trial to further reveal the effectiveness of ih and explore its potential mechanisms.

Eligibility criteria:
inclusion criteria: * informed written consent from the volunteers. * healthy volunteers between ages of 18 and 45 years, body mass index (bmi) of 19.0 and 24.9 kg/m2. * long-term residence at flatland (altitude of \<100 m), not having been to an altitude ≥1500 m in 30 days. * resting peripheral oxygen saturation of more than 90%, cerebral oxygen saturation between 58%-82%, heart rate between 60 bpm and 100 bpm, and blood pressure within the normal range (90-130/60-80 mmhg). exclusion criteria: * history of cardiovascular, cerebrovascular, pulmonary, hepatic, dermatologic, or hematologic diseases. * history of substance abuse. * the use of medications or medical devices. * pregnancy, hypertension, diabetes mellitus, obesity, sleep apnea and neurological disorders.
agreement between oral and cervical human papillomavirus infection in a french cohort

Conditions: Human Papillomavirus-Related Cervical Carcinoma

Summary: human papillomaviruses (hpvs) are the most common of sexually transmitted viral agents and they are associated with genital and oral diseases. agreement between cervical and oral hpv infection has been described from a small group of patient. our study, performed on a greater number of patients, will provide a good estimation of this link, between cervical and oral infection, in a french population of women with a primary cervical hpv infection.


Eligibility criteria:
inclusion criteria: * histologic proven of cervical intraepithelial neoplasia or carcinoma in situ (cis) or invasive cervical cancer or a pap smear on which at least one hpv has been detected * patients not vaccinated against hpv * age \>18 years * eocg performance status ≤ 3 * patient must be affiliated to a social security system * ability to provide written informed consent patient's legal capacity to consent to study participation and to understand and comply with the requirements of the study exclusion criteria: * patients vaccinated against hpv * pregnant woman over 10 weeks * patient who underwent head and neck radiotherapy dating less than one year * patients deprived of liberty or under supervision

Keywords: cervical hpv infection oral hpv infection sexually transmitted infection
caudal epidural prolotherapy versus steroids in failed back surgery syndrome

Conditions: Chronic Pain Syndrome

Summary: this study will be held on patients with failed back surgery syndrome, the investigators are comparing prolotherapy and steroids injections in caudal epidural space to relieve the pain

this study is a prospective double blinded randomized controlled study. it will be held on patients with failed back surgery syndrome aged between 20 and 70 years old, one group will receive ultrasound and fluoroscopy-guided injection of prolotherapy in caudal epidural space while the other group will receive ultrasound and fluoroscopy-guided injection of steroids in the caudal epidural space 40 patients will be included in each group

Eligibility criteria:
inclusion criteria: 1. patients diagnosed with failed back surgery syndrome, having chronic pain for more than 3 months by a detailed assessment including medical history and examination 2. patients having positive radiological (mri) findings of spinal nerve roots being irritated or compressed after having surgery for one of many conditions including: lumbar disc herniation, spinal canal stenosis, osteophytes, spodylolithesis or foramen stenosis 3. patients whom another surgery is not indicated exclusion criteria: 1. patient refusal 2. pregnancy 3. systemic infection or infection at the site of injection 4. patients on anticoagulation 5. immunocompromised patients as uncontrolled diabetes, osteoporosis as a contraindication for steroid injection 6. patients with renal impairment or on dialysis 7. acute disc prolapse as it requires immediate surgery 8. opioid use 9. concurrent significant depressive illness, inflammatory of joint disease.

Keywords: caudal epidural prolotherapy steroids failed back surgery
copeptin- relevance as a perioperative marker in pediatric cardiac surgery

Conditions: Congenital Heart Disease

Summary: this study evaluates the relevance of copeptin in children with congenital heart disease undergoing cardiac surgery with the need of cardiopulmonary bypass. three blood samples are taken of each patient. the first and second sample are collected in the operation room before and after the procedure and the third sample on the first postoperative day at the intensive care unit.

objective: vasopressin is a hormone secreted by the posterior pituitary gland. its main functions are constriction of blood vessels and reabsorption of water and thereby regulating water balance and hemodynamics of the body. copeptin is a cleavage product in the synthesis of vasopressin and is released in equimolar amounts. its stability makes it easier to determine the amount of vasopressin. it is known, that the use of a heart-lung machine in cardiac procedures has effects on the water balance of the body and may affect the vasopressin secretion. the aim of this prospective clinical trial is, to figure out if copeptin would be suitable for perioperative risk evaluation in neonates and children with congenital heart disease after surgery with the use of a heart-lung machine. hypotheses: the primary outcome endpoint of this study is the change in copeptin concentration perioperatively in patients with congenital heart disease, with the use of heart-lung machine. secondary outcome endpoints are correlations between copeptin concentration and complexity of the procedure (based on the aristotle basic score), clinical status and the perfusion times of the heart-lung machine.

Eligibility criteria:
inclusion criteria: * ≤6 years of age * chd * need of hlm for surgery * informed consent of parents * not participating in other studies exclusion criteria: * preoperative ventilatory support * preoperative circulatory support (ecmo, vad) * diabetes insipidus * preoperative cpr * preoperative shock * preoperative sepsis * preoperative vasopressin application

Keywords: copeptin pediatric cardiac surgery heart lung machine