Kornimate/medical-research-clean huggingface dataset:
holographic screens as a replacement of monitors during gi endoscopies

Conditions: Gastrointestinal Diseases

Summary: nowadays, the application and development of spatial technologies have shown an increased interest in different fields of medicine, especially in procedural specialties. many studies have shown the utility of augmented and virtual reality; however, studies evaluating mixed reality are scarce. in gastroenterology, some proposed advantages of mr are the 3d space guidance, its increased situational awareness, remote assistance, and the reduction of surgical monitors in the units. based on this, the researchers proposed a multicenter trial to assess the added value of mr through a holographic device during gastroenterology endoscopic procedures.

in the medical field, many technologies have emerged to aid healthcare providers during training, communication, and management of patients. the area of spatial computing is becoming part of the immersive developing technology. the main components of spatial computing are augmented, virtual, and mixed reality (ar, vr, and mr, respectively). vr is a human-computer interface that simulates a realistic environment, while ar superimpose elements of vr in a real-world environment. ar is an enhanced version of the real-world achieved through sensory information delivered via technology. moreover, the combination of both is known as mr. mixed reality is an interactive, real-time processed, three-dimension registered technology. in medicine, published data has broadly demonstrated the utility and advantages of ar and vr in many fields like neurosurgery, cardiology, maxillofacial, hepatobiliary, and orthopedics. however, information about mr for health purposes is scarce. based on the above, it is necessary to develop studies to assess the utility of mr in other procedural medical fields like gastroenterology. some of the proposed advantages of mr in gastroenterology, mainly during endoscopic procedures, are the 3d space guidance and gesture operation (translation and rotation) without touching the object, the increase in situational awareness by reduction of real-world and content refocusing, the remote assistance during procedures, and the replacement/reduction of the use of monitors during the procedures. to evaluate the advantages and added value of mr in gastroenterology, the researchers proposed a multicenter trial in the endoscopic units by using a built developed application (hxtendtm, mdconsgroup, guayaquil, ecuador) for the hololens2tm (microsoft, redmond, wa, usa) holographic device.

Eligibility criteria:
inclusion criteria: * expert gastrointestinal endoscopists performing diagnostic colonoscopy, cholangioscopy, ercp or eus evaluation/intervention * written informed consent provided exclusion criteria: * refuse to participate in the study or to sign corresponding informed consent * internet connection less than 100 mbs per second.

Keywords: augmented reality endoscopy gastrointestinal virtual reality mixed reality
evolution of the health status of caregivers after the admission of their elderly relative to the emergency department

Conditions: Caregiver-patient Dyeds; Patient Without Cognitive Disorders

Summary: the main objective of this non-interventional, propective and multipercentric study is to assess the evolution of caregiver burden 1 month after their elderly relative's emergency department (ed) admission

the aim purpose of this non-interventional, prospertive study is to compare the evolution of caregiver burden between inclusion and 1month after their elderly relative's ed admission. inclusion of caregivers - patients dyads, meeting inclusion criteria and agreeing to participate, is carried out by geriatric mobile teams (emg) working within emergengy department. at inclusion the following data will be collected: for the patient : * presence of neurocognitive disorders * sociodemographic data (age, gender, lifestyle) * patient comorbidities * autonomy and independence * risk of early readmission and loss of autonomy for the caregiver: * socio-demographic data * the caregiver's burden * quality of life * resilience capacity will be measured the follow-up of the caregiver is carried out 1 month after the passage of his elderly relative to emergency department (at inclusion). the levels of burden and quality of life as well as the aids set up at home will be collected

Eligibility criteria:
inclusion criteria: * adult caregivers - patients aged 75 and over dyads consulting in emergency department and living at home * patients admitted to the emergency department for less than 48 hours for which a return home is decided * non-verbal opposition of the patient and caregiver to the collection of their data. exclusion criteria: * hospitalized patient after emergency * patient admitted to emergency for life-saving emergency * patient living nursing home (ehpad) * language barrier * absence of identified caregivers * severe cognitive impairment as per diagnostic and statistical manual of mental disorders (dsm-5) criteria and absence relative at time of inclusion * patients under guardianship * oral opposition from the patient and caregiver to their data collection.

Keywords: caregiver-patient dyeds emergency department
metabolic response following intake of 2 metabolic preconditioning drinks

Conditions: Starvation

Summary: surgical patients are usually starved for 8 to 12 hours before operation in order to reduce the chances of vomiting and other complications during the anaesthetic. recent studies have suggested that this period of starvation might be harmful as it 'weakens' or 'stresses' the body before the operation. to avoid these harmful effects of starvation, patients are now given carbohydrate drinks (sugar-containing drinks that provide energy for the body) up to 2 hours before the operation. these drinks have been shown to make patients feel better, reduce sickness after the anesthetic/surgery and result in quicker recovery from operation. but the ways in which the sugar drinks have these beneficial effects on the body are unknown. the optimum time of giving these drinks to patients before operation is also unknown. this study will investigate the hormone responses of the body, following intake of 2 different carbohydrate drinks, in order to determine the optimum time of intake of these drinks in order to obtain the maximum benefits for the body.


Eligibility criteria:
inclusion criteria: * healthy male caucasian volunteers aged 18-40 years, * bmi of 20-25 kg/m2, * able to give voluntary written informed consent to participate in the study, - able to understand the requirements of the study, including anonymous publications, and * agree to co-operate with the study procedure. exclusion criteria: * any history of acute or chronic illness, smoking, regular medication or substance abuse, or * have taken part in any other clinical study within the previous 3 months.

Keywords: dietary supplement healthy volunteers anaesthesia for surgery
applying artificial intelligence to identify subphenotypes of acute kidney injury in mexican patients with severe covid-19

Conditions: COVID-19; Acute Kidney Injury

Summary: the goal of this observational study was to identify subphenotypes of acute kidney injury patients with covid-19, and the investigators analyzed their impact on mortality. the study included demographic and clinical variables of the participants. the implementation of machine learning algorithms and artificial intelligence methods are used, and some specific implementations were designed for the analysis, where each group was characterized by traditional statistical methods.


Eligibility criteria:
inclusion criteria: * patients older than 15 years old, hospitalized, and with severe acute respiratory syndrome (sars-cov-2) positive confirmation. exclusion criteria: * patients who did not have at least 1 creatinine measurement.

Keywords: machine learning artificial intelligence
quality assessment in exposure therapy

Conditions: Obsessive-Compulsive Disorder in Children

Summary: this project will test a measure of treatment quality, exposure guide, for therapists using exposure therapy for youths and young adults with anxiety or ocd. we anticipate that users of this measure will be able to complete it reliably, find it acceptable, and that the measure will predict patient outcome. this project will include 40 therapists treating 300 anxious youth and young adults ages 5-25 at a large community mental health agency. results of this study will establish the exposure guide as a measure of exposure quality in real world settings.

empirically supported behavioral treatments cannot be effectively disseminated without understanding key quality components. mechanism-informed quality measures have extraordinary potential to enhance pragmatism by eliminating unnecessary elements and targeting multiple problems and populations, and to enhance predictive value by detecting mechanism engagement early in treatment. community mental health agencies (cmhas), however, are often ill-equipped to use such measures of treatment quality due to burden and limited resources. exposure therapy for anxiety is an ideal prototype for testing a practical, mechanism-informed quality measure in cmhas given its potential for public health impact and clear theory of mechanism. the exposure guide (eg), a brief quality tool measuring therapist behaviors and mechanism, was developed based on microanalytic coded data showing a strong link between therapist behavior and patient outcome across three rcts of exposure therapy in youth. initial psychometrics for the eg using these rct data are promising showing reliability, construct validity, and predictive validity, and pilot data suggests it may be acceptable and feasible in a community setting. building upon these findings, we propose to test this novel measure of exposure quality, eg, in a community setting including its reliability and validity, its pragmatism, and which community end-users can become reliable and valid reporters. therapists at a large local cmha (n = 40) treating anxious youth and young adults ages 5-25 (n = 300) will participate in this study. the eg will be completed by 1) agency supervisors monthly, 2) therapists per session, 3) patient/families per session, and 4) study raters per session. results from this study will establish an innovative model for measuring therapeutic elements that trigger mechanism of change in real-world therapy as well as inform future use of eg as a training tool to improve exposure quality in community settings.

Eligibility criteria:
inclusion criteria: * patient at a community mental health agency that is partnering with this study * primary or co-primary diagnosis of ocd, separation anxiety, social anxiety, panic disorder, or specific phobia. * children \< age 12 have a caretaker available to participate in treatment * patient and parent/legal guardian are english speaking exclusion criteria: * concurrent psychotherapy for treatment of anxiety * psychosis, pervasive developmental disorder, or mental retardation
effects of daily walnut intake among the subjects with metabolic syndrome

Conditions: Metabolic Syndrome

Summary: investigators planed to conduct a randomized, controlled, crossover trial to examine the effects of daily walnuts intake among korean subjects with metabolic syndrome. primary objective of this study was to investigate the effects of daily walnut intake on changes of metabolic syndrome indices in koreans with metabolic syndrome age over 30 years old. this study was consisted of four periods: run-in, first intervention, wash-out, and second intervention phases. as 16 weeks of first intervention period began after the run-in phase, the subjects were randomly assigned into one of two groups: walnut group and control group. participants in walnut group consumed 45 grams of walnuts on a daily basis and participants in control group were provided iso-caloric white bread for first 16 weeks. after the first intervention and wash-out period (6 weeks), second intervention which is crossover of first intervention was started during the next 16 weeks. anthropometric measurements and biochemical analyses were done at the beginning and the end of each intervention (0, 16, 22, and 38 weeks of trial). habitual diet was randomly observed using 3-day diet record once during each phase. investigators expected to evaluate 1)effects of walnut ingestion on reverting metabolic syndrome to normal status especially by reducing waist circumference and improving serum levels of triglyceride and high-density lipoprotein, 2)beneficial effects of daily walnut consumption on changes of body composition in the subjects with metabolic syndrome, and 3)regulatory effects of daily walnut intake on inflammatory markers and diabetic markers.


Eligibility criteria:
inclusion criteria: at least three out of five metabolic syndrome components * waist circumference (wc) \>90 cm for men and \>80 cm for women * hypertension (dbp ≥85 and \<110 mm hg) * hyperglycemia (≥100 mg/dl) * elevated plasma tg concentrations (≥150 mg/dl) * decreased plasma hdl-c concentrations (\<40 mg/dl for men and \<50 mg/dl for women) exclusion criteria: * the presence of morbid obesity (bmi ≥40) * the use of any medication for the control of blood pressure, glucose, or lipid metabolism * a medical history of hypocaloric diet consumption within the past year * gastrointestinal tract disorders * post-menopausal women * smokers
salto - epidemiological study on compliance and treatment satisfaction

Conditions: Thromboembolism

Summary: patients that are on total knee/hip replacement initiate prophylaxis treatment on the hospital ground. once they leave the hospital, as outpatients they continue with the treatment at least during two consecutive weeks. patients will be instructed to follow treatment recommendations (either lmwh or oral treatment, at physician discretion) and to come back to the surgeon after that period. at that visit, the treatment satisfaction questionaire with medication (tsqm) test as well as the moriski-green questionaire (measures compliance with medication) will be answer by the patient. tsqm is an self administered validated scale (validated also in spanish) that measures in a generic way the treatment satisfaction to a treatment. morinski-green test will be used to measure the compliance degree on medication.


Eligibility criteria:
inclusion criteria: * patients in antithrombotic prophylaxis treatment after total knee/hip replacement. this is an epidemiological study where the patients to be included will be those that are treated with antithrombotics as out-patients in real life conditions. exclusion criteria: * patients who has been previously treated with injectable antithrombotic treatments. * diabetic patients treated with insulin. * patients who do not sign informed consent form.

Keywords: arthroplasty antithrombotic prophylaxis treatment replacement knee
impact of iit-sit on dengue clusters

Conditions: Dengue

Summary: this randomized controlled trial aims to evaluate the efficacy of wolbachia-infected male mosquitoes combined with sterile insect technique (iit-sit) to mitigate active dengue transmission in singapore.

aedes-borne diseases are expected to increase in geographical coverage and intensity due to climate change and rapid urbanization. it has been demonstrated that wolbachia-mediated incompatible insect technique coupled with sterile insect technique (iit-sit) is highly effective in suppressing aedes populations and subsequently reducing dengue risk. however, the efficacy of the tool in mitigating ongoing transmission is unknown. the researchers outline a randomized controlled trial to be conducted in high-rise public housing estates in singapore to assess the efficacy of iit-sit to mitigate active dengue transmission. specifically, the study will determine whether the release of male wolbachia-infected aedes aegypti mosquitoes can curtail the growth of dengue clusters, defined operationally by the singapore national environment agency (nea) as two or more reported dengue cases within a 150-meter radius and with illness onset dates within 14 days of each other. this study will randomize eligible clusters into intervention/control arms in real-time. clusters assigned to the intervention arm will receive iit-sit treatment until cluster extinction (i.e. when no further cases are linked to the cluster). this trial closely mimics how iit-sit could be used as an additional tool for outbreak management, by treating areas with active dengue transmission in real-time. conventional vector control measures will be carried out as per nea's usual outbreak management practices in both intervention and control clusters. the intervention efficacy will be estimated through two primary endpoints: (1) probability of cluster extinction, as estimated from the time-to-cluster extinction among intervention versus control clusters; and (2) final size of the dengue cluster, as estimated by the difference in the final number of dengue cases in intervention versus control clusters. this study will provide evidence from a randomized controlled trial for the efficacy of iit-sit in curbing ongoing transmission and provide an epidemiological basis for integrating iit-sit into the existing arsenal of outbreak management tools. the trial will assess the technology's feasibility for operationalization, and identify difficulties in implementation prior to larger-scale use for outbreak control.

Eligibility criteria:
eligible dengue clusters will be limited to public housing estates and with at least 10 dengue cases comprising that dengue cluster before allocation into intervention or control arms. the selected clusters will be in areas with relatively high sector-level gai of at least 0.2 at the time of the 10th reported case. additionally, the first 10 cases must be reported within 30 days of the first case. additionally, clusters must be in areas which have never experienced wolbachia-aedes releases and at least 700 m away from existing wolbachia-aedes release areas.
optimizing left ventricular lead to improve cardiac output

Conditions: Ischemic Congestive Cardiomyopathy; Dilated Cardiomyopathy; Congestive Heart Failure

Summary: the purpose of this study is to determine if optimal lead placement, guided by the largest improvement in aortic flow measured by doppler will: 1. improve the way the heart's left ventricle functions 2. decrease the number of hospital admissions for heart failure related symptoms 3. reduces uncoordinated heart contractions 4. improve quality of life as measured by the minnesota living with heart failure questionaire and nyha class assessed after six months

the hypothesis of this study determines if response to crt therapy could be improved by optimizing lv lead position at the time of the left ventricular pacing lead implantation. this optimization (using a doppler wire) would alter the left ventricular activation pattern and contraction mechanics. this increase in contractility may improve the likelihood of mid/long term response to therapy. this study will compare 6-month response to crt (left ventricular ejection fraction, decrease in left ventricular end systolic and end diastolic dimensions and volumes) in heart failure patients. the secondary objective will be to: 1. to determine if optimal lead placement, guided by the largest improvement in stroke volume, results in a greater 6-month improvement in clinical qol and nyha class. 2. acutely compare and/or correlate intra-operative a-v and v-v timing optimization via invasive pressure volume data to post-operative echo optimization of these same parameters. 3. acutely contrast changes in stroke volume during pacing from several different left ventricular lead locations.

Eligibility criteria:
inclusion criteria: * clinical indication for crt-p or crt-d * qrs duration\>=120 msec * left ventricular ejection fraction\<=35% * nyha class iii-iv * history of cardiomyopathy, least one month post mi, or at least six months old in case of non-ischemic cardiomyopathy * at least 18 years of afe exclusion criteria: * previous implanted crt-p/crt-d * woman who are pregnant * psychological or emotional problems

Keywords: cardiac resynchronization therapy medically refractory heart failure patients
cortical correlates of spatial navigation skills in an immersive virtual reality environment

Conditions: Cerebral Palsy (CP)

Summary: the goal of this study is to investigate the neural mechanisms that undergoes spatial navigation skills in children/adolescents aged between 8 and 17 years. these skills play an important role in daily life, as they allow us to orient ourselves in familiar and unfamiliar environments, locate objects, interact with them and memorize their position. navigation abilities vary widely between individuals, change with age and might be affected by diseases, such as the cerebral palsy (cp). previous studies have, in fact, demonstrated differences in the learning and adaptation methods of spatial navigation skills in children affected by cp compared to typically developing (td) peers. through the use of the electroencephalogram (eeg) we want to shed light on the mechanisms that govern this ability with the aim of: 1. better characterize spatial navigation skills in children/adolescents, both td and affected by cp; 2. investigate the origin of the differences found between the spatial navigation skills of td children and those affected by cp, improving knowledge of the pathology and thus allowing, in the future, to identify more adequate rehabilitation interventions.


Eligibility criteria:
inclusion criteria: * typically developing subjects aged between 8 and 17 years; * subjects with cp aged between 8 and 17 years; exclusion criteria: * subjects aged under 8 or over 17 years; * subjects with epileptic problems; * subjects with poor head control; * subjects with visual problems that can not be corrected with prescription lens;

Keywords: navigation skills eeg virtual reality cerebral palsy