Kornimate/medical-research-clean huggingface dataset:
helmet vs face mask in patients with acute respiratory distress syndrome

Conditions: Acute Respiratory Distress Syndrome; Noninvasive Ventilation; Corona Virus Disease; Acute Respiratory Failure

Summary: the objective of this study is to evaluate the efficacy of noninvasive ventilation with helmet in reducing endotracheal intubation rates in comparison with noninvasive ventilation (niv) facemask among patients with acute respiratory distress syndrome (ards)


Eligibility criteria:
inclusion criteria: * patients with (acute respiratory distress syndrome) ards as per berlin definition * age: 18 and more exclusion criteria: * patients with altered sensorium \[glasgow coma scale (gcs) less than 13\] * pregnancy * hemodynamic instability * morbidly obese * patients with tracheostomy * severe acidosis \[ph less than 7.15\] * patients with glaucoma * patients with history of vertigo
gynecological pelvic floor muscle training

Conditions: Urinary Incontinence

Summary: a randomized controlled trial pilot study to test the efficacy of a pelvic muscular training intervention led by a physiotherapist on urinary incontinence, quality of life and sexual health in women who report urinary urgency and incontinence following surgery and radiation treatment for gynecological cancer vs. usual care (a 1-page sheet on kegel exercises).


Eligibility criteria:
inclusion criteria: - treated with surgery and adjuvant treatment, including radiation, for gynecological cancer within the last 3 years exclusion criteria: * stage iv cancer or stage iii and iv cervical cancer * radiation not part of treatment * known spinal or long bone metastases diagnosis with a neuromuscular disorder that may impact pelvic floor muscle function * urinary incontinence issues prior to cancer diagnosis * scheduled or previous surgical treatment of incontinence * fecal incontinence * body mass index (bmi) \> 35 * use of medications to improve bladder function * unable to complete questionnaires in english or unable to actively participate in physiotherapy treatment provided in english.

Keywords: training physiotherapy pelvic floor muscles
vildagliptin 50 mg twice daily in patients with type 2 diabetes mellitus inadequately controlled with metformin

Conditions: Type 2 Diabetes Mellitus

Summary: the study is designed to demonstrate the short term efficacy and safety of vildagliptin 50 mg bid in patients with type 2 diabetes mellitus inadequately controlled with metformin.


Eligibility criteria:
inclusion criteria: * patients who sign the informed consent * hba1c in the range of \> 7 to ≤10.5% at visit 1 * ability to comply with all study requirements exclusion criteria: * pregnant or lactating women * serious cardiovascular disorders * liver/renal disease or dysfunction * anti-diabetic other than metformin, thiazolidine, or α-gi or insulin * laboratories values abnormalities as defined by the protocol

Keywords: metformin vildagliptin t2dm
paracetamol versus dipyrone after pediatric lower abdominal surgery in children with spinal anesthesia

Conditions: Other Acute Postoperative Pain

Summary: we conducted a prospective, randomized double-blind study to compare the effectiveness of intravenous paracetamol and dipyrone for preventing pain during early postoperative period in school-age children undergoing lower abdominal surgery with spinal anesthesia.

the intensity of postoperative pain was assessed using a visual analog scale (vas) (0 represented no pain and 10 the worst pain ever experienced) at 15, 30, 60th minutes, and 2nd, 4th, 6th hours postoperatively.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologist (asa) physical status i and ii children undergoing elective lower abdominal surgery exclusion criteria: * increased intracranial pressure hemorrhagic diathesis infection at the puncture site those with a known history of allergy to the study drugs

Keywords: pediatric spinal anesthesia, paracetamol, dipyrone
beta2-adrenergic agonism and muscle remodelling

Conditions: Hypertrophy; Physiologic Hypertrophy; Physical Activity

Summary: the study aims to investigate gender-specific adaptations to beta2-adrenoceptor stimulation with selective short- and long-acting beta2-agonist with emphasis on skeletal muscle in relation to performance enhancing effects and anti-doping


Eligibility criteria:
inclusion criteria: * healthy men and women, aged 18-45 years * vo2max \>55 ml/kg/min for men and \>50 ml/kg/min for women (± biologic and techinical variation of 5.6% (katch et al. 1982) * body mass index (bmi) \< 26 exclusion criteria: * chronic user of beta2-agonist or allergy towards study drugs * serious adverse side effects of the used study drug * chronic disease that by the project physician would affect any of the outcomes of the study * smoker * chronic use of prescription medication (other than contraceptives for women) * pregnancy

Keywords: proteome vo2max muscle function exercise performance skeletal muscle doping anti-doping enantiomeric analysis
the effect of home-based monitoring, exercise training

Conditions: COPD Patients

Summary: chronic obstructive pulmonary disease (copd); from time to time, significant involvement in dusts or gases and abnormal disease outbreaks are observed, which are observed throughout life in the period when the cause has just emerged, interruption of air flow with disruptions in air flow, shortness of breath, increase in the amount of secretion. directly or indirectly, very high costs are incurred in copd care and promotion. while mild stages are treated without directed hospitalization, hospitalizations become more frequent as the disease progresses, and the duration of hospitalization in each acute attack increases compared to the next attack. acute exacerbations of copd negatively affect the rates of rehospitalization and emergency service admissions, and the living conditions of this condition, whose long-term cause of death and morbidity has not yet been revealed, do not lead to negative aspects. exercise programs applied in chronic diseases should include stopping their illnesses, increasing sleep during the disease, stopping inflammatory acuteness, and in addition to treatment, the rest of the patients should be normal. it has been stated that it is more effective than home-based hospital system applications in pulmonary regulation, and it has been taken positively from applications compatible with the basic field, as everywhere in the world. in this direction, the effect of home-based monitoring, education and exercise training applied to individuals with copd via tele-consultancy method on repeated hospitalization and quality of life is revealed.


Eligibility criteria:
inclusion criteria: * agreeing to participate in the research, * diagnosed with copd, * able to use a smartphone, * oriented and cooperative, * does not have a psychiatric disorder that impairs verbal communication, such as schizophrenia or dementia, * having no communication problems. exclusion criteria: * having alcohol or drug addiction, * those with physical disabilities, * illiterate.
to assess signs and symptoms in women affected by gsm after one cycle of pixel co2-alma fractionated laser

Conditions: Genitourinary Syndrome of Menopause (GSM); Vaginal Dryness; Burning; Pain; Dyspareunia; Dysuria

Summary: genitourinary syndrome of menopause (gsm) occurs in approximately 50% of menopausal women but is both underrecognized and undertreated despite numerous treatment options. vaginal dryness, irritation, dyspareunia, urinary frequency, and urinary urgency are some of the more common symptoms that can have a negative effect on women's lives and relationships. in particular, dyspareunia is localized in the vestibule with specific trophic changes more evident than those localized in vagina. the co2 fractionated laser, has also been found to be useful in several studies for the treatment of vaginal atrophy. in this open comparative study, 70 female menopausal subjects aged between 40 and 70 years old at inclusion, having symptoms of gsm (vaginal dryness, burning/pain, dyspareunia,dysuria), have given her informed consent and meet all the eligibility criteria, will be enrolled. the two groups of comparison will be 35 subjects treated into vagina and vestibule, versus 35 subjects treated into vagina, only. subjects will come to a total of 6 visits over a period of 3 months. the primary objective of the study is to evaluate the performance and safety of pixel co2-alma fractionated laser comparing its administration into vagina and vestibule versus into vagina, only. the evaluated outcomes are vaginal dryness, burning/pain, dyspareunia, sensitivity to touch at swab test, female sexual function index (fsfi) and vulval pain functional questionnaire (vq) at day 84 and 120 and the safety during all the study. the secondary objectives are the evaluation of vaginal and vestibular trophism, measured by vaginal health index (vhi) and vestibular health score (vhs) at the fu visits.


Eligibility criteria:
inclusion criteria: * menopausal women aged between 40 and 70 years old (defined as absence of menstruation for 12 consecutive months). * women affected by genitourinary syndrome of menopause (gsm) with vaginal dryness, burning/pain, dyspareunia, dysuria. * women not treated with replacement therapy with estrogen and progestogen (ht) or estrogen alone (et) or selective estrogen receptor modulators (serms) in the last 3 months exclusion criteria: * hypersensitivity to laser * clinically significant findings on physical examination * any chronic medical condition or psychologic disorder that per opinion of the principal investigator would make the patient ineligible for the study * vulvo-vestibular lesion not related with gsm * active vaginal or vulvar infections (e.g., herpes, candida, stis) * prolapse beyond the hymen * subject has a history of scarring alteration (ie, keloid formation) * unknown past or active history of vaginal bleeding disorders * any condition or behavior indicating to the principal investigator that the subject is unlikely to be compliant with study procedures and visits

Keywords: genitourinary syndrome of menopause (gsm) fractionated laser vaginal dryness. dyspareunia
a study to evaluate the efficacy and safety of ppb-r-203-based meal versus tk9-based meal in 20 patients with diabetes

Conditions: Diabetes Mellitus

Summary: to evaluate the efficacy of ppb-r-203-based meal and tk9-based meal on blood glucose control in 20 patients with diabetes for 2 days.

the minimed medtronic cgms (continuous glucose monitoring system), the first model approved by fda, was used for subcutaneous glucose monitoring. the cgms continually measures the glucose concentration of the interstitial fluid every 10 seconds and then stores an average glucose value for each 5 minutes period, for a total of up to 288 measurements each day.

Eligibility criteria:
inclusion criteria: 1. diabetes mellitus patient. 2. aged between 20 to 65 years old. 3. informed consent form signed. exclusion criteria: 1. a recent history of drug or alcohol abuse. 2. sensitivity to analogous product. 3. serious cardiovascular disorders. 4. participation in another clinical investigation study. 5. ongoing influenza, autoimmune disease and other metabolic diseases. 6. pregnant or lactating women. 7. individuals are judged by the investigators or co-investigator to be undesirable as subjects.

Keywords: diabetes mellitus continuous glucose monitoring system (cgms)
open label continuation study in moderate to severe psoriasis

Conditions: Moderate to Severe Plaque Psoriasis

Summary: the purpose of this study is to evaluate long term safety, efficacy and tolerability of abt-874 in adults with moderate to severe psoriasis.


Eligibility criteria:
inclusion criteria: * having participated in a preceding abt-874 clinical trial for abt-874 * subject has a clinical diagnosis of moderate to severe plaque psoriasis exclusion criteria: * subjects who prematurely discontinued in any preceding psoriasis study with abt-874 other than protocol-required discontinuation

Keywords: open label
the effect of kegel exercise in nursing students with primary dysmenorrhoea

Conditions: Primary Dysmenorrhea

Summary: in this study, it was aimed to determine the effect of kegel exercise on menstruation symptoms, severity of dysmenorrheic symptoms and quality of life in nursing students with primary dysmenorrhea. the study was conducted as a single-blind randomized controlled trial.

the study was conducted in a single-blind randomized controlled trial with 89 nursing students with primary dysmenorrhea. the experimental group was given kegel exercise training online, and after the training, a message was sent to remind them to do kegel exercises three times a day during the follow-up. no intervention was made in the control group. hypotheses of the research 1. vas total scores in interventions involving kegel exercise training and regular kegel exercise are lower than control interval rates (h1). 2. the total score of the menstruation symptom scale within the participants who participated in kegel exercise training and regular kegel exercise was recorded, at lower rates than the distribution of control intervals (h1). 3. the severity of dysmenorrheic symptoms in participants who participated in kegel exercise training and regular kegel exercise interventions were lower than the distribution of control intervals (h1). 4. the total scores of the quality of life scale among those who participated in kegel exercise training and regular kegel exercises were higher than the proportions of the controlled rankings (h1).

Eligibility criteria:
inclusion criteria: * be between the ages of 18-25 * giving 6 points or more to the least menstruation pain on the day that individuals experience the most severe dysmenorrhea symptoms (vas) out of 10 points on the vas visual pain scale * being nulliparous (never giving birth) * regular menstruation for the last six months * not having any gynecological diagnosis * not having had a gynecological operation * volunteering to participate in the study exclusion criteria: * being a man * being married * being diagnosed with secondary dysmenorrhea * giving menstruation pain less than 6 points out of 10 on the vas visual pain scale. * taking painkillers 12 hours before the assessments.

Keywords: primary dysmenorhea kegel exercise nursing students exercise
effects of lower trapezius strengthening versus scapular mobility exercise among snooker players in unilateral neck pain

Conditions: Sports Physical Therapy

Summary: effects of lower trapezius strengthening versus scapular mobility exercise among snooker players in unilateral neck pain.

effects of lower trapezius strengthening versus scapular mobility exercise on pain, range of motion and disability among snooker players in unilateral neck pain.

Eligibility criteria:
inclusion criteria: * age between 18 - 35 years, * males snooker players * neck pain perceived by individual as being on one side of the neck pain 3 or more month in duration. * participants with 6-7 level of pain on nprs scale * participants with scapular mobility limited exclusion criteria: * neck pain perceived by individual as being centrally located or on both sides of neck. * radicular symptoms * history of cervical spine surgery * traumatic neck injury * underlying neurological condition

Keywords: disability lower trapezius strength strengthening exercise mobility exercise unilateral neck pain
dancesing care evaluation: testing the effectiveness

Conditions: Older Adults; Healthy Aging; Aging; Quality of Life; Depression, Anxiety; Stress, Physiological

Summary: this pilot randomised controlled trial aims to compare the effectiveness of a 12-week music and movement intervention in older adults in care homes compared to a waitlist control group. the main questions it aims to answer are: * do salivary cortisol and dheas levels improve after the intervention, compared to the waitlist control group? * do feelings of anxiety and depression improve after the intervention, compared to the waitlist control group? * does the quality of life improve after the intervention, compared to the waitlist control group? * does physical function improve after the intervention, compared to the waitlist control group? participants will engage in music and movement sessions three times per week for 12 weeks. researchers will compare the intervention group to the waitlist control group to see if any effects occur.


Eligibility criteria:
inclusion criteria: * residents in care homes ≥ 65 years, * able to complete 12 weeks of a movement and music program, * having the capacity to give informed consent as assessed by care staff and confirmed in discussion about the project with the research team using the british psychological society capacity checklist exclusion criteria: * currently taking part in any other clinical trial which could potentially have an impact upon or influence the findings of the current study, * pre-existing conditions or concurrent diagnoses which would profoundly impact their capacity to undergo the intervention, even once adaptations have been made, * inability to adequately understand written/spoken english to participate in the measures and intervention (e.g., due to cognitive or sensory impairment).

Keywords: randomised controlled trial clinical trial music and movement intervention care home cortisol dheas
aim2act: a mobile health tool to help adolescents self-manage asthma

Conditions: Asthma

Summary: the aim is to test the efficacy of aim2act and long-term maintenance of treatment effects in a fully-powered randomized controlled trial with 160 early adolescents with poorly controlled persistent asthma, ages 12-15 years, and a caregiver


Eligibility criteria:
inclusion criteria are: 1. adolescent is 12-15 years old 2. caregiver is between 18-70 years-old 3. adolescent lives in the residence of caregiver 4. adolescent and caregiver can speak and read english 5. (a) adolescent has been diagnosed as having asthma, or (b) doctor has stated the adolescent has asthma, or (c) adolescent has had breathing problems in the past 12 months 6. adolescent has had an active inhaled corticosteroid prescription for ≥ 4 weeks 7. (a) during the past 14 days (that is, during the past fourteen 24-hour periods that include daytime and nighttime), the adolescent has experienced one or more of the following: (i) asthma symptoms such as wheezing, shortness of breath, or tightness in the chest, or cough on more than 4 separate days; (ii) woken up because of asthma symptoms such as wheezing, shortness of breath, or tightness in the chest, or cough on 1 or more separate nights; (iii) had to slow down or stop play or usual activities or missed school because of asthma, wheezing, or tightness in the chest, or cough on more than 4 separate days; (iv) used any asthma rescue medicine (sometimes called a quick relief medicine) on more than 4 separate days * or (b) in the past year, adolescent has had one or more of the following: (i) 2 or more exacerbations requiring oral systemic corticosteroids; (ii) 2 or more emergency department visits; (iii) 1 hospitalization; (iv) 2 or more urgent medical care visits due to asthma * or (c) adolescent scores 19 or lower on the asthma control test exclusion criteria are - families will be excluded if: 1. the family is currently involved in an asthma management intervention above and beyond usual care, or 2. adolescent is unable to complete study procedures independently.

Keywords: adolescent
time-restricted eating with exercise

Conditions: Obesity

Summary: the purpose of the study is to determine if body composition differs between early time restricted eating (8-hour feeding period from 7 am to 3 pm) with exercise and late time restricted eating (8-hour feeding period from 3 pm to 11 pm) with exercise in overweight adults.

time-restricted eating (tre) is a hot trend in weight-loss diets. tre can reduce cardio-metabolic risks, thereby lowering body weight, blood pressure, lipid profile, glucose, and inflammation. the most effective way for the overweight population to improve body composition is to incorporate tre with exercise. however, there were only two tre interventions in humans that included exercise, suggesting that the additive effect of tre to exercise may be dependent on dietary timing. tre can be divided into early tre (etre) and late tre (ltre), depending on the time of day of the eating window. however, whether different tre schedules with exercise can improve cardio-metabolic health is questionable. there have been no interventions of different tre schedules with exercise. this study will be beneficial for determining which tre schedule with exercise is efficacious to prevent cardio-metabolic disease.

Eligibility criteria:
lists of inclusion criteria: the participants will be allowed to participate in this study if they 1. are adults, aged between 18-30 years 2. are apparently healthy and physically inactive (defined as any form of physical activity performed \< 2 days per week) 3. are overweight (bmi 25-\<30 kg/m2) 4. are non-smokers 5. are free from the following chronic medical conditions: heart disease, arrhythmias, diabetes, thyroid disease, bleeding disorder, history of pulmonary disease, hypertension, hepatorenal disease, musculoskeletal disorder, neuromuscular/neurological disease, autoimmune disease, cancer, peptic ulcers, anemia, or chronic infection (hiv) 6. are free from the orthopedic conditions that would hinder physical activity 7. have not taken any heart, pulmonary, thyroid, anti-hyperlipidemic, hypoglycemic, anti-hypertensive, endocrinological (e.g, thyroid, insulin, etc), emotional/psychotropic (e.g,prednisone, ritalin, adderall), neuromuscular/neurological, or androgenic medications(anabolic steroids) 8. have low risk for cardiovascular disease and with no contraindications to exercise as outlined by the american college of sports medicine (acsm) will be included. lists of exclusion criteria: the participants will not be allowed to participate in this study if they 1. are younger than 18 years and older than 30 years. 2. have consumed any medication for chronic medical condition. 3. are participating in weight management programs. 4. have constrictions to exercise. 5. are currently exercising regularly (at least 2 days per week).
arginine as an adjuvant treatment against tuberculosis

Conditions: Tuberculosis; HIV

Summary: the purpose of this study was to investigate if adjuvant treatment with arginine (the substrate for nitric oxide production) rich food supplements could improve clinical outcome in patients with smear positive tuberculosis by affecting nitric oxide production.

tuberculosis (tb) is disease of increased global public health importance. because of emerging multi drug resistance and the long treatment duration there is a need to optimize the current chemotherapy. host immunity is important in determining the susceptibility and outcome of disease as could be exemplified by co infection with hiv which dramatically increases the risk to develop tb. previous results from our group and others show that nitric oxide produced by activated macrophages from arginine might be important to control the disease. however, the relative importance of nitric oxide in human tb has been debated. in a previous study in gondar, ethiopia, we observed an effect of adjuvant treatment with arginine capsules on sputum smear conversion and reduction of cough. in this study we wanted to test the hypothesis based on previous observations that an arginine rich food supplementation might enhance clinical improvement in patients with smear positive tuberculosis and if this effect could be due to increased nitric oxide production.

Eligibility criteria:
inclusion criteria: * informed and written consent to take part in the study * previously untreated and newly diagnosed smear positive tb patients according to the who definitions exclusion criteria: * hospitalization * pregnancy * known allergy against peanuts * chronic or acute disease other than tuberculosis/hiv

Keywords: arginine nitric oxide peanuts sedimentation rate