Kornimate/medical-research-clean huggingface dataset:
guided bone regeneration using synthetic membrane

Conditions: Jaw, Edentulous; Jaw, Edentulous, Partially

Summary: the purpose of this study is to examine the safety and usefulness of the regenecure guided bone regeneration membrane for stimulating bone growth in patients that don't have enough bone for dental implant placement. the study will include 16 patients in each group, 20 non-smokers and 12 smokers, a total of 32 patients will participate in the study.


Eligibility criteria:
inclusion criteria: * subject must have voluntarily signed the informed consent form before any study related action * age: 18 to 65 with missing teeth, seeking for implant therapy. * men/women * in good systemic health * present with no contra indication against oral surgical interventions * single/ multiple tooth gap - have at least one missing tooth in the mandible or maxilla, requiring one or more dental implants. * the tooth at the implant site(s) must have been extracted or lost at least 6 weeks before the date of implantation. * bone defect(s) must be present with a lateral dimension greater than or equal to 5 mm or less. * full mouth plaque score (fmpi) lower or equal than 25% * patients must be committed to the study exclusion criteria: * medical conditions requiring prolonged use of steroids * use of bisphosphonate intravenously * current pregnancy or breastfeeding women * alcoholism or chronically drug abuse * immunocompromised patients * uncontrolled diabetes * conditions or circumstances, in the opinion of the investigator, which would prevent completion of study participation or interfere with analysis of study results, such as history of non-compliance, or unreliability. * untreated inflammation * mucosal diseases or oral lesions * history of local irradiation therapy * persistent intraoral infection * patients with bad oral hygiene or unmotivated for normal home care.

Keywords: guided tissue regeneration dental implants membrane, synthetic
the construction and application of a mobile health management program for elderly depression based on the patterns of cognitive function changes

Conditions: Patients With Depression in the Elderly

Summary: based on the changing law of cognitive function, combined with the behavior change wheel theory and the health behavior process orientation model, we constructed a mobile health management program for geriatric depression. the aim is to explore the effect of this intervention program on the health behavior of elderly patients with depression; and to verify the effect of the intervention program on improving the primary outcome and other secondary outcomes of elderly patients with depression, with a view to providing a scientific basis for the management of depression in the elderly and promoting the optimization of personalized intervention strategies.

based on the changing law of cognitive function, combined with the behavior change wheel theory and the health behavior process orientation model, we constructed a mobile health management program for geriatric depression. the aim is to explore the effect of this intervention program on the health behavior of elderly patients with depression; and to verify the effect of the intervention program on improving the primary outcome and other secondary outcomes of elderly patients with depression, with a view to providing a scientific basis for the management of depression in the elderly and promoting the optimization of personalized intervention strategies.

Eligibility criteria:
inclusion criteria: * ① meet the clinical diagnosis of geriatric depression and dsm-5 diagnostic criteria; ② age ≥ 60 years old, clear consciousness; ③ be able to communicate in mandarin, with a certain degree of comprehension and expression; ④ possess a smart phone and have the ability to operate it in a basic way; ⑤ voluntarily participate in this study and sign an informed consent form exclusion criteria: * ①previous or current cognitive impairment and other severe mental illnesses that prevent cooperation with the study;②comorbidities such as severe cardiac, hepatic, or renal impairment
the effect of a virtual navigator on colorectal cancer patient empowerment

Conditions: Colorectal Cancer

Summary: for individuals diagnosed with colorectal cancer, exposure to up-to-date cancer information and support as well as guidance to access the most appropriate health care services is crucial for cancer self-management and support. timely access to high quality cancer information is suggested to contribute to patient empowerment - defined as the perception of being better able to manage illness demands. with the advent of the information age, individuals are increasingly turning to online health information resources. the use of rigorous web-based tools is found to be an engaging and convenient way to access health information, while being tailored to people's needs and preferences. the present study seeks to examine the effects of a recently developed high quality and person-centred web-based tool, the oncology interactive navigator (oin) on patients' empowerment as well as document its cost-effectiveness. participants newly diagnosed with colorectal cancer will be randomly assigned to experimental or control groups with the former having unrestricted access to the oin for 8 months. participants in the control group will receive care as usual. information on background, medical characteristics, and empowerment will be collected as well as cost-effectiveness indicators. if producing the desired effects, the oin could be proposed for national implementation across canadian cancer centers. work is currently underway to add over 23 types of cancer diagnosis to the oin.


Eligibility criteria:
inclusion criteria: * histologically confirmed, first diagnosis of colorectal cancer (all stages) * within 20 weeks of when the individual was told s/he has colorectal cancer * fluent in english or french; able and willing to complete questionnaires * unrestricted home internet access * has used the internet at least once in the past * informed consent exclusion criteria: * previous history of crc at any time, or any other cancer diagnosed within the last 5 years (exception: superficial skin cancer) * medical or severe health problem * terminal phase of colorectal cancer or too sick to participate

Keywords: virtual patient navigation randomized clinical trial empowerment cost-effectiveness cancer information preferences
impact of therapeutic plasma exchange on rna biomarker expression levels in alzheimer's patients

Conditions: Alzheimer Disease

Summary: the study will determine if therapeutic plasma exchange removes rna biomarkers associated with alzheimer's disease and how quickly those biomarkers reappear after treatment.

participants with a diagnosis of alzheimer's or mild cognitive impairment will undergo therapeutic plasma exchange as part of their treatment for the disease as per the ambar trial protocol. patients will undergo one non-invasive tests to assess their microvascular system and complete one online test to assess the degree of cognitive impairment. patients will have their blood drawn pre-plasma exchange, immediately post plasma exchange and repeated assessments and blood draws at seven day intervals post plasma exchange ending on the twenty-eighth day after the plasma exchange. their blood will be analyzed by fbb biomed to identify the presence of unique rna biomarkers associated with alzheimer's disease and determine how quickly they regenerate.

Eligibility criteria:
inclusion criteria: 1. subject is scheduled to undergo their first tpe procedure for a diagnosis of alzheimer's disease or previous mental/cognitive impairment 2. mentally capable of understanding and completing informed consent for the study. exclusion criteria: 1. subject is unable or failed to return/provide blood specimen on days seven (7), fourteen (14) , twenty-one (21), and twenty-eight (28) (plus or minus 1 day on follow up draws) post plasma exchange 2. subject is unable to provide informed consent.
clinical progressive characteristics and treatment effects of 2019-novel coronavirus

Conditions: Pneumonia Caused by Human Coronavirus

Summary: objects: the purpose of this study was to observe the characteristics of morbidity, disease progression and therapeutic effects of 2019-novel coronavirus pneumonia patients with different clinical types. method: a single center, retrospective and observational study was used to collect covid-19 patients admitted to wuhan infectious diseases hospital (wuhan jinyintan hospital) from january 2020 to march 2020. the general information, first clinical symptoms, hospitalization days, laboratory examination, ct examination, antiviral drugs, immune enhancers, traditional chinese medicine treatment and other clinical intervention measures were recorded, and the nutritional status and prognosis of the patients were recorded. confirm covid-19 's disease progression, clinical characteristics, disease severity and treatment effects. to compare the characteristics of disease progression, clinical features, disease severity and therapeutic effect of different types of covid-19. outcomes: the characteristics of disease progression, clinical features, disease severity and therapeutic effect of different types of covid-19. conclusion: the characteristics of disease progression, clinical features and therapeutic effect of different types of covid-19.

since december 2019, patients with unexplained pneumonia have appeared in some medical institutions in wuhan, china. nucleic acid testing was completed on january 10, 2020, which was confirmed to be caused by 2019-novel coronavirus. in 2020, the world health organization(who) named the virus 2019-novel coronavirus(2019-ncov). the who announced that the pneumonia caused by 2019-ncov is officially called covid-19. today, more than 70,000 cases have been confirmed and more than 2,000 patients have died. at present, the epidemiological characteristics, laboratory indicators, imaging features and clinical treatment effects of covid-19 should be reported, but the sample size is small. large sample studies are still needed to further confirm covid-19 's disease progression, clinical characteristics, disease severity and treatment effects, so as to provide a scientific basis for future clinical treatment. therefore, it is particularly important to further review the relationship between the characteristics and prognosis of such patients.

Eligibility criteria:
inclusion criteria. 1. 2019-ncov (sara-cov-2) nucleic acid positive detected by pcr. 2. older than 18 years old and younger than 75 years old. 3. meet the diagnostic criteria of covid-19 for different types (including ordinary type, heavy type and critical type) exclusion criteria. 1. the age is less than 18 years old; 2. pregnant or lactating women; 3. severe underlying diseases, such as advanced malignant tumor, end-stage lung disease, etc.

Keywords: 2019-novel coronavirus pneumonia
elucidation of breast milk composition and structure over the first year of lactation: uc davis lactation study

Conditions: Healthy; Gestational Diabetes Mellitus; Type 2 Diabetes Mellitus

Summary: this observational study is designed to determine how sugars, lipids and proteins in breast milk vary among mothers; is affected by maternal diet, health and microbiota and vary over the course of lactation. additionally, the study is designed to determine how the structure and composition of complex milk sugars, maternal health status and diet influence the development and maintenance of infant gut microflora.

this study's objectives include: 1) develop a better understanding of the composition and structures of breast milk over the early stages of lactation with specific emphasis on the glycans and lipids; 2) how glycan diversity relates to maternal and infant gut microbiota with an emphasis on bifidobacteria species; 3)how milk composition and structure relate to maternal health and diet. these samples will be analyzed using comprehensive gas and liquid chromatographic methods, nuclear magnetic resonance (nmr) spectroscopy and mass spectrometry (ms); and next generation sequencing, terminal restriction fragment length polymorphism and quantitative polymerase chain reaction. there are several cohorts to the main study. gestational diabetes mellitus cohort. the aim of this study is to investigate the differences between milk composition, infant and maternal gut microbiota from women with and without gestational diabetes mellitus or type 2 diabetes vs. controls. fresh milk study. the aim of this study is to elucidate the relationship between the expression of glycan metabolizing genes of mammary epithelial cells and levels of milk glycans. rna study. the aim of this study is to compare the rna of milk fat globule membrane crescents in human milk against epithelial expression profiles in non-human primate milk. skin study. the aim of this study is to provide skin samples from healthy term infants to act as the control group for a different study with preterm infants. breast milk, gut microbiome, and immunity (bmmi) project. the aim of this study is to provide healthy control samples for the bmmi project. the bmmi project is a multi-investigative project designed to elucidate how maternal nutrient status, and milk composition and structure influence infant gut microbiome from participants in developing countries.

Eligibility criteria:
inclusion criteria: * pregnant women 18 years and older who plan to breastfeed for at least 6 months * women who are in good health * women with or without diagnosis of gestational diabetes mellitus, or type 2 diabetes mellitus or impaired glucose tolerance exclusion criteria: * women who do not plan to breastfeed for at least 6 months * women who give birth to pre-term infants * women who smoke, either currently or 1 year before becoming pregnant * women who have chronic medical conditions or communicable diseases * women who take metabolic altering drugs such as corticosteroids or thyroid medication
evaluation of a gatekeeper training program

Conditions: Suicide

Summary: the main objective of the proposed study is to evaluate the efficacy of a gatekeeper training suicide intervention program, applied suicide intervention skills training (asist), in improving medical students' knowledge about suicide intervention, impact of attitudes on someone at risk for suicide and competent use of intervention skills to recognize risk and intervene effectively compared to medical education as usual. this research project will be undertaken using a randomized-controlled trial design. questionnaires and objective structured clinical examinations using simulated patients will be completed at three time points: 1) before training, 2) after training, and 3) at one year following the training. medical students' clinical skills in recognizing risk and intervening with simulated patients, as well as knowledge about suicide intervention and the impact of attitudes on someone at risk for suicide will be evaluated.

the current proposal plans to implement and evaluate a secondary suicide intervention skills training program (gatekeeper training) in medical school students in winnipeg, manitoba, canada. the main objective of the current proposal is to evaluate the effectiveness of a gatekeeper training program, applied suicide intervention skills training (asist), in improving medical students' intervention skills with suicidal patients compared to training as usual. secondary aims include comparisons of changes in knowledge, perceived competence and attitudes around suicide. findings from previous studies have demonstrated a significant positive effect of gatekeeper training on suicide prevention attitudes, skills and knowledge. as well, general studies in medical education reveal that students who have been able to practice, observe, and receive feedback in small groups showed an improvement in skills and confidence over those who were given didactic teaching only. therefore, the investigators anticipate that the asist training program will significantly improve medical students' knowledge about suicide intervention, and will increase their recognition and response to suicide risk compared to education as usual. the investigators also expect that asist training will help them to understand the impact of attitudes on suicide prevention, and will increase their perceived competence and ability to recognize and treat a suicidal individual compare over training as usual. it is hypothesized that medical students trained in asist will differ significantly in their ability to correctly recognize and intervene with suicidal individuals based on their use of a standardized suicide intervention model and objective assessment using standardized patients.

Eligibility criteria:
inclusion criteria: * all medical students at university of manitoba exclusion criteria: * those who choose not to participate * those who have already taken asist training or related safetalk training
comparison of floseal hemostasis tonsillectomy with coblation tonsillectomy and cautery hemostasis tonsillectomy

Conditions: Adenotonsillar Hypertrophy; Tonsillitis; Obstructive Sleep Apnea

Summary: the purpose of this study is to evaluate a new method of hemostasis, floseal gel, in tonsillectomy and adenoidectomy, with the goal of decreasing post operative and intraoperative morbidity.

blood loss and postoperative morbidity following adenotonsillectomy in children can be significant. the current technique for performing a tonsillectomy is "cold steel tonsillectomy" with electocautery hemostasis and a newer technique of coblation tonsillectomy. postoperative pain has been shown to be increased in patients undergoing extensive electrocautery, with less pain seen in patients undergoing coblation tonsillectomy. the purpose of the study is to evaluate the clinical efficacy and complications of floseal matrix hemostatic sealant for use in patients undergoing adenotonsillectomy compared with two other currently used techniques. the study is a prospective, controlled clinical trial comparing floseal hemostasis in "cold steel" knife dissection tonsillectomy with cautery hemostasis in "cold steel" knife dissection tonsillectomy and coblation tonsillectomy in a pediatric population. all children under the age of 18 without previous documented coagulopathy scheduled to undergo tonsillectomy will be offered enrollment in the study. informed consent will be obtained from the patient's legal guardian. the goal of this study is to determine if floseal reduces intraoperative blood loss, time to hemostasis, and postoperative morbidity in patients undergoing tonsillectomy compared with two other commonly used methods. also, we wish to evaluate the complication rates following floseal administration compared to those of electrocautery and coblation.

Eligibility criteria:
inclusion criteria: * patients less than 18 years old scheduled for a routine adenotonsillectomy exclusion criteria: * down syndrome * craniofacial abnormality

Keywords: adenotonsillectomy coblation tonsillectomy floseal
retrospective study: long-term health of living kidney donors

Conditions: Kidney Diseases

Summary: kidney transplantation, is the preferred treatment option of end stage renal disease. compared to dialysis, patients who receive kidneys have a 70% reduction in death, a dramatically improved quality of life and cost the health care system considerably less. as a result, there are over 3000 canadians on the waiting list for a kidney. in order to meet the shortage of cadaveric kidneys, the rates of living kidney donation have nearly doubled over the last 10 years. yet despite its advantages for the recipient, living kidney donation remains a complex ethical, moral, and medical issue. the premise for accepting living donors is that the "minimal" risk of short and long-term medical harm realized by the donor is outweighed by the definite advantages to the recipient and potential psychosocial benefits of the altruistic gift to the donor. the only benefit for the living donor is psychological - donors experience increased self-esteem, feelings of well-being, and improved health related quality of life with their altruistic act of assuming medical risk to help another. the short-term consequences of living donation are well established. on the other hand the long-term consequences of living kidney donation are far less certain. the main medical concerns of living kidney donation include an increased risk of hypertension, proteinuria, and low glomerular filtration rate (gfr- a measure of the filtering capacity of the kidney). estimates of these outcomes are variable, inconsistent, and uncertain in the literature. this study is designed to quantify the long-term medical and psychosocial implications of living kidney donation.


Eligibility criteria:
inclusion criteria: * age greater than 18 years old * living kidney transplant occurred between 1970 and 2006 * no history of hypertension, kidney disease or proteinuria prior to donation exclusion criteria: * a medical condition (such as cardiovascular disease, pulmonary disease, or active cancer) which makes one ineligible to be a donor. blood group and immunological incompatibility (such as positive cross-match, poor hla matches) are not reasons for exclusion. * the eligible non-donor subsequently went on to donate a kidney * either the donor or the eligible non-donor are unable to give informed consent * the living donor or eligible non-donor is currently pregnant

Keywords: long term outcome living kidney donor
replacement gastrostomy tubes: technical and clinical comparison of five commercial models

Conditions: Gastrostomy Tube Rupture; Gastrostomy Tube Durability; Gastrostomy Tube Convenience

Summary: multiple models of replacement tubes for percutaneous endoscopic gastrostomy are available in the market, however durability is variable. in a prospective randomized study, five commercial devices available in the market will be tested in 20 consecutive patients each. tube performance will be observed during 6 months and durability will be assessed by kaplan-meier curves as well as cox regression analysis.it is hypothesized that tube design and material will influence outcome.

multiple models of replacement tubes for percutaneous endoscopic gastrostomy are available in the market, however durability is variable. in a prospective randomized study, five commercial devices available in the market will be tested in 20 consecutive patients each,in patients submitted to long-term outpatient nutritional support. tube performance will be observed during 6 months and durability will be assessed by kaplan-meier curves as well as cox regression analysis.it is hypothesized that tube design and material will influence outcome.this study is important because tube dysfunction and unscheduled changes are expensive troubles that disrupt the nutritional protocol and are responsible for multiple inconveniences to the patient and the caretaker.

Eligibility criteria:
inclusion criteria: * adults undergoing long-term home enteral nutrition via percutaneous endoscopic gastrostomy due to neurologic conditions or dysphagia. * registered at the outpatient endoscopy service * clinical stable and with the possibility of returning for scheduled visits * expected duration of enteral feeding \> 6 months exclusion criteria: * sepsis, * shock, * coma, * other types of digestive access (surgical gastrostomy, jejunostomy) * terminal disease, * lack of cooperation, * refusal to participate in the protocol

Keywords: gastrostomy tube endoscopic replacement tube rupture durability tube loss balloon rupture