Kornimate/medical-research-clean huggingface dataset:
effects of strength training on musculoskeletal overuse injuries in female runners

Conditions: Overuse Injury

Summary: the purpose of this study is to look at the effect of strength training in preventing overuse injuries in female runners

this randomized clinical trial will compare the effects of 9-months of strength training to a control group on: (1) injury rates in female runners during the 9 month intervention period, and for 9 months after completing the intervention, and (2) on the potential mechanisms of injury including strength, joint and tissue loading, and psychosocial factors.

Eligibility criteria:
inclusion criteria: * female civilian runners between 18-60 years old * run at least 5 miles per week for the past 6 months * no overuse injuries in the past 6 months * plan to stay in the area for the next year and a half * live less than 30 miles from wake forest university or high point university exclusion criteria: * male * under age 18 and over age 60 * chronic diseases, orthopedic conditions, past anterior cruciate ligament tears * currently pregnant or planning to conceive within the next 18 months * observed by study staff as unwilling to attend testing/intervention sessions * observed by study staff as unwilling to communicate via telephone and email regularly with study personnel * participated in formal strength training in the past 6 months * current active military or active military reserve
single incision laparoscopic surgery in treating patients with colorectal disease

Conditions: Adenomatous Polyp; Crohn Disease; Familial Adenomatous Polyposis; Hereditary Intestinal Polyposis Syndrome; Recurrent Colon Cancer; Stage I Colon Cancer; Stage IIA Colon Cancer; Stage IIB Colon Cancer; Stage IIC Colon Cancer; Stage IIIA Colon Cancer; Stage IIIB Colon Cancer; Stage IIIC Colon Cancer

Summary: this study is being done to evaluate single incision laparoscopic surgery (sils) for colorectal diseases, compared to multi-port laparoscopic surgery. this study is also intended to standardize the sils technique for colorectal diseases

primary objectives: i. to report the experience of sils procedure in the treatment of colorectal disease. ii. to standardize the sils technique. outline: patients undergo single incision laparoscopic surgery with gelport® attachment. after completion of study treatment, patients are followed up at 2 weeks, 3 and 6 months, and at 1 year.

Eligibility criteria:
inclusion criteria: * patients who are willing to give consent and comply with the evaluation and the treatment schedule * patients with disease processes limited to the right colon; this will include crohn's disease, polyp disease, and cancers of the right colon * american society of anesthesiologists (asa) =\< 3 exclusion criteria: * inability to obtain informed consent * previous right colon surgery * previous extensive abdominal surgery that would limit the laparoscopic approach * stage iv disease at surgery * metastatic disease diagnosed by computed tomography (ct), magnetic resonance imaging (mri), or nuclear imaging * patient enrolled in other interventional study * asa score greater than 3 * any condition which precludes compliance with the study (investigator discretion) * co-morbid condition(s) that could limit the subject's ability to participate in the study or to comply with follow-up requirements, or that could impact the scientific integrity of the trial

Keywords: colorectal disease sils colorectal surgery
periosteal stimulation for knee osteoarthritis

Conditions: Osteoarthritis, Knee

Summary: 185 veterans with chronic knee pain and advanced knee osteoarthritis will be recruited to participate in this study designed to test the effectiveness of a special type of electrical acupuncture called periosteal stimulation (pst). participants will be divided into three groups. they will receive pst or a control condition once a week for 10 weeks. two-thirds of the participants will receive booster sessions periodically over the course of the next 6 months. everyone will be called monthly during the 6 month period and then will be asked to return for an evaluation on site at the end of this period.

we have performed a promising initial trial of periosteal stimulation (pst, that is, electrical stimulation of 4 acupuncture needles around the knee that touch periosteum) as an analgesic for older veterans with advanced knee osteoarthritis (oa) and daily pain. the primary aim of the proposed trial is to optimize and sustain the efficacy of pst for reducing pain in veterans with advanced knee oa and unrelieved pain by combining it with booster pst. our secondary aims are to 1) improve physical performance in these individuals, and 2) ascertain the physical and psychological predictors of response to pst. in a randomized controlled clinical trial, 180 veterans (age 50 and older) with persistent knee pain who have x-ray evidence of advanced oa will be assigned to one of three intervention groups: 1) control pst once a week for 10 weeks (i.e., needle placement with brief stimulation of non-periosteal needles), 2) pst once a week for 10 weeks followed by tapering pst boosters over 6 months, or 3) pst once a week for 10 weeks followed by tapering control-pst boosters over 6 months. prior to initiating the intervention, immediately after the last session, and 6 months later, the following parameters will be assessed: 1) pain severity (womac), 3) physical performance (gait velocity, stair climb, repetitive chair rise, timed up and go), and 4) psychological function (mood, coping, self-efficacy). monthly telephone calls will assess pain, interim illness and physical activity.

Eligibility criteria:
inclusion criteria: * english speaking, * knee pain on most days of the past 3 months that is more severe than pain in other parts of the lower body, * advanced knee oa by x-ray, * age 50-89 exclusion criteria: * non-ambulatory or severely impaired mobility (i.e., require the use of a walker), * folstein mmse \< 24, * severe uncorrected visual or hearing impairment, * knee pain due to factors other than oa, * large knee effusion, * history of corticosteroid or hyaluronic acid injection in the affected knee(s) during the preceding 3 months, * acute or terminal illness, * immune suppression, * anticoagulation therapy, * pacemaker, * prior pst treatment * active participation in other studies currently * age \>89

Keywords: acupuncture
exploring the effects of aerobic exercise combined with bfrt on patients with copd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: investigate the effects of exercise training on the cardiopulmonary function and exercise capacity in copd patients.

the systemic effects of chronic obstructive pulmonary disease (copd) can precipitate a series of complications, including cardiovascular disorders, muscle atrophy, and osteoporosis. these comorbid conditions often result in decreased physical activity and suboptimal physical fitness, compelling patients to lead a sedentary lifestyle to mitigate exercise-induced dyspnea. addressing the limitations in exercise tolerance remains a critical therapeutic goal in the treatment of copd. according to research, exercise intolerance is caused by both poor pulmonary function and associated skeletal muscle dysfunction. blood flow restriction training, a new rehabilitation technique, has shown promise in improving muscular strength at lower exercise intensities and in shorter timeframes, presenting a fresh approach to copd rehabilitation. the research aims to investigate the impact of incorporating blood flow restriction training into a holistic aerobic exercise program on exercise capacity and quality of life among patients with copd. the findings are intended to clarify the potential of this innovative training technique as a supplementary therapeutic strategy in the management of copd.

Eligibility criteria:
inclusion criteria: 1. copd classified as levels 2-4. 2. stable condition without worsening in the past three months. 3. no participation in any rehabilitation program within the past six months. 4. ability to understand and follow verbal commands and cooperate with an exercise training program. exclusion criteria: 1. unconscious or unable to cooperate with the evaluator. 2. hospitalization due to acute illness within the past three months. 3. severe joint diseases or history of lower limb surgery. 4. severe cardiovascular disease (e.g., presence of a cardiac pacemaker or acute myocardial infarction within the past six months). 5. dependence on oxygen supply.

Keywords: blood flow restriction training chronic obstructive pulmonary disease
the effect of cognitive functions on upper extremity functionality in parkinson's patients

Conditions: Parkinson; Cognitive Impairment; Upper Extremity Problem; Functional Disturbance

Summary: parkinson's disease (pd), first described by james parkinson in 1817, is a progressive movement disorder that develops mainly as a result of the destruction of nigrostriatal dopaminergic neurons. the aim of our study is to determine the effect of cognitive functions on upper extremity functionality in individuals with parkinson's disease.

parkinson's disease (pd), first described by james parkinson in 1817, is a progressive movement disorder that develops mainly as a result of the destruction of nigrostriatal dopaminergic neurons. involvement of nigrostriatal dopaminergic neurons is associated with the motor manifestations of the disease. the most common of these symptoms are; resting tremor, bradykinesia, rigidity and balance disorder. however, non-motor symptoms related to the involvement of nervous system structures other than the dopaminergic nigrostriatal system can be observed in pd. however, due to the predominance of motor symptoms in pd, it took many years to notice cognitive changes. traditionally, cognitive impairments in pd have been expected to occur in the advanced stages of the disease. however, cognitive impairments in the early stages are reported in approximately 30-35% of patients. cognitive dysfunction is defined in pd, ranging from mild impairments in certain cognitive domains to severe dementia. cognitive impairment primarily affects executive and visuospatial functions, and memory is secondarily affected. executive functions are higher cognitive processes that use and modify information from many cortical sensory systems in the fore and hindbrain areas to modulate and teach behavior. the frontal cortex, especially the prefrontal cortex and its striatal connections are very important neuroanatomical regions for executive functions. the relationship between the effects of cognition and motor performance and parameters in groups such as the elderly, pd and alzheimer's patients in which these centers are affected has been an issue that has attracted the attention of many researchers. most of the studies have focused on the lower extremity performance of cognition. however , it has been reported that cognition has positive effects on upper extremity performance and early acquired upper extremity skills have positive effects on cognitive performance . the aim of our study is to determine the effect of cognitive functions on upper extremity functionality in individuals with parkinson's disease.

Eligibility criteria:
inclusion criteria: * having a diagnosis of parkinson's disease. * not having hearing and vision problems. * to be able to take the commands required for the manual dexterity tests. * agree to participate in the study. exclusion criteria: * having undergone musculoskeletal surgery for the upper extremity. * having vision and hearing problems. * having an additional disease that may affect cognitive tests.

Keywords: parkinson cognitive function upper extremity
a 28-day polysomnographic study of gabapentin in transient insomnia induced by a sleep phase advance

Conditions: Transient Insomnia

Summary: the purpose of this study is to to assess the effect of gabapentin compared to placebo on sleep, using polysomnography along with subjective sleep assessments, in subjects with transient insomnia induced by a sleep phase advance.


Eligibility criteria:
inclusion criteria: * 18 years of age or older with occasional sleeplessness in the month prior to screening exclusion criteria: * current treatment for, or recent history (within 2 years) of, a sleeping disorder including excessive snoring, obstructive sleep apnea or a chronic painful condition that interferes with the subject's sleep * currently taking or expected to take any of the following during trial: amphetamines, benzodiazepines, cocaine, marijuana, methaqualone, methadone, opiates, propoxyphene, barbiturates, and phencyclidine during their participation in the trial
the ratio of femoral vein diameter to femoral artery diameter to predict fluid responsiveness in children

Conditions: Pediatric ALL; Fluid Overload

Summary: the hypothesis of the study will be that the ratio of femoral vein diameter to femoral artery diameter will have correlation with fluid status in pediatrics.

proper administration of intravenous fluids is an important part of treating circulatory failure in children and affects the clinical outcome of the management of the child's emergency. giving a small amount of fluid will cause tissue hypoperfusion and worsen organ dysfunction and cause ischemia. on the other hand, excess fluid interferes with oxygen delivary, exacerbates treatment outcomes, increases complications, and extends both the length of the stay in intensive care and mortality. the use of bedside ultrasound by pediatric intensive care physicians has become so critical in recent years that it is now a component of physical examination in icus

Eligibility criteria:
inclusion criteria: * children with american society of anaesthesiologist physical status 1-2 * 2-10 years of age * scheduled for elective surgery * signs of moderate to severe dehydration exclusion criteria: * patients with mild dehydration. * patients with history of significant comorbid conditions or previous laparotomy. * congenital heart disease. * heart failure. * disorder of venous return like arteriovenous fistula, dvt or varicose veins. * increase intra-abdominal pressure.
a phase ii study of an anti-tumor immunotherapy regimen comprised of pegylated interferon-alpha 2b and hyperacute melanoma vaccine for subjects with advanced melanoma

Conditions: Melanoma

Summary: the purpose of this study is to determine the safety of giving subjects with advanced, recurrent or refractory melanoma the hyperacute® melanoma vaccine with a variant of a drug, called interferon (peg-intron®) that is specially formulated to be given on a weekly basis (instead of daily). the study vaccine (hyperacute®-melanoma) is made from three types of human melanoma cell lines (grown in the laboratory) in which the genes have been slightly changed. this clinical study will try to discover the safety of the study vaccine combined with peg-intron®, its side effects and the potential benefits, if any.

this study will look at the anti-tumor vaccine effect, side effects and toxicity of the hyperacute® vaccine with peg-intron®. it is hoped that the immune system's response to these genetically engineered melanoma cells and peg-intron® will cause a reaction that will make it react to and attack and kill the melanoma cells and keep it from growing, possibly causing the tumors to shrink. patients that are eligible are 19 years or older and have been diagnosed with advanced, treatment resistant or recurrent melanoma, an aggressive usually pigmented form of skin cancer.

Eligibility criteria:
inclusion criteria: * 19 years or older * histological diagnosis of melanoma * ajcc stage iiic (any t, n1b, n2b, n3, m0) or stage iv (any t, and n, m1), metastatic, progressive, refractory, recurrent or high risk of recurrence melanoma. * expected survival of more than 6 months * adequate organ function * measurable or non-measurable disease * must have negative serologies for hepatitis b and c and hiv prior to entering study * must be more than 4 weeks since major surgery, radiotherapy, chemotherapy or biotherapy/targeted therapies * male and female subjects of child producing potential must agree to use contraception or avoidance pregnancy measures while enrolled on the study and for one month after the last immunization. exclusion criteria: * active cns metastases or carcinomatous meningitis * hypercalcemia * pregnant or nursing women * other malignancy within five years * history of organ transplant or current active immunosuppressive therapy * subjects taking systemic corticosteroid therapy * active infection or antibiotics within 1-week prior to study * uncontrolled or significant congestive heart failure, myocardial infarction, ventricular arrhythmias or pulmonary dysfunction * autoimmune disease * a known allergy to any component of the hyperacute vaccine or peg-intron * patients having undergone splenectomy * patients with sickle-cell anemia or thalassemia major.

Keywords: advanced melanoma
acute exacerbation of copd and physical activity - preliminary study

Conditions: Chronic Obstructive Pulmonary Disease

Summary: people with chronic obstructive pulmonary disease (copd) are very sedentary and efforts to establish an active lifestyle are challenging because of periodic acute exacerbations of copd that interrupt physical activity patterns and contribute to further decline in physical activity. the purpose of this preliminary research is to learn more about the experience of acute exacerbations of copd (aecopd) from the perspective of the patient and his/her family and to learn how aecopds affect physical activity.

individuals with chronic obstructive pulmonary disease (copd) are very sedentary and their physical activity is often interrupted by acute exacerbations of copd (aecopd). little is known about the expectations had by individuals with copd and the effects of these expectations on their physical activity. to increase the understanding of these expectations in people with copd, a study is proposed to explore their experience of daily fluctuations in symptoms and aecopds, focusing on how these experiences influence health promoting behaviors, especially physical activity (pa). this study will involve an enrollment visit during which consent will be obtained, survey data will be administered (that they may take home), spirometry testing will be conducted, and a physical activity monitor (activpal device) will be applied to be worn one week to allow us to understand their usual pa. a clinical ethnographic interview will then be conducted one week following enrollment, at which point the questionnaires and activpal device will be collected. a second clinical ethnographic interview will be conducted one week following the first. survey data will again collected at week 15 by mail.

Eligibility criteria:
inclusion criteria: * people who have emphysema or chronic bronchitis as their primary health problem * people who have had a respiratory infection or an exacerbation of their copd within the last year. * people who are 55 years or older * family member of someone who meets the above criteria. exclusion criteria: * other lung diseases as their primary pulmonary problem. * mobility problems that limit physical activity
reduced dissemination of tumor cells with primary ligation of the inferior mesenteric vein in rectal cancer patients.

Conditions: Rectal Cancer

Summary: effect of ligation sequence of the inferior mesenteric artery and vein on circulating tumor cells and survival in laparoscopic rectal cancer surgery: a prospective, multicenter, randomized controlled study (arvects)

several studies have demonstrated that the presence of circulating tumor cells (ctcs) in the peripheral blood can be a surrogate biomarker to predict recurrence and prognosis of rectal cancer. ctcs are released from the primary tumor into the bloodstream and have the potential to spread to distant sites and develop into micro-metastatic deposits. numerous studies have demonstrated that surgical manipulation could promote the dissemination of tumor cells into the circulation. theoretically, the potential risk of tumor cell dissemination can theoretically be minimized if the effluent vein was ligated first. however, there is no regulation in the current guidelines on the sequence of ligation of the inferior mesenteric artery and vein during rectal cancer surgery owing to a lack of sufficient evidence. this multi-center randomized controlled trial is to investigate effect of ligation sequence of the inferior mesenteric artery and vein on circulating tumor cells and survival in laparoscopic rectal cancer surgery

Eligibility criteria:
inclusion criteria: 1. age: 18-75 years; 2. histopathologically confirmed as rectal adenocarcinoma(tumor located within 15 cm from the anal verge at colonoscopy); 3. patients with a stage i-iii rectal cancer eligible for surgery and r0 resection is expected, patients with pelvic lateral lymph nodes metastasis are ineligible; 4. ecog score: 0-1; 5. asa score: i/ii/iii; 6. laparoscopic surgery; 7. informed consent. exclusion criteria: 1. patients who have received preoperative treatment (such as preoperative radiotherapy and chemotherapy); 2. receiving transanal total mesorectal excision (tatme), specimen extraction through natural lumen (noses) ; 3. recurrent rectal cancer; 4. simultaneous or metachronous colorectal cancer; 5. malignant tumors of other organs in the past 5 years or at the same time; 6. the results of preoperative physical examination and imaging examination showed that: (1) the tumor involved the surrounding organs and required combined organ resection; (2) distant metastasis; (3) could not be resected at r0; 7. pregnant or lactating women; 8. patients with severe mental disorder; 9. it is not suitable for patients undergoing laparoscopic surgery (such as extensive adhesion caused by previous abdominal surgery or inability to tolerate artificial pneumoperitoneum); 10. history of unstable angina pectoris or myocardial infarction in the past 6 months; 11. have a history of cerebrovascular accident in the past 6 months; 12. systemic administration of corticosteroids within 1 month before enrollment; 13. taking folic acid related drugs within half a year before operation. 14. severe cardiac insufficiency (fev1\<50% of predicted values); 15. emergency surgery.