Kornimate/medical-research-clean huggingface dataset:
genomic profiling of nodular thyroid disease and thyroid cancer

Conditions: Thyroid Nodule; Thyroid Cancer; Thyroid Diseases; Thymic Carcinoma

Summary: the purpose of this registry is to collect uniform genomics-centered data on patients with nodular thyroid disease and cancer in a prospective fashion. after initial clinical evaluation patients with thyroid nodules will undergo standard ultrasonographic evaluation and a needle biopsy of the thyroid (fine needle aspiration (fna) or core biopsy) as clinically indicated. biopsy samples will be evaluated cyto-pathologically. a molecular/genomic profiling will be obtained using thyroseq v2 test. surgical treatment will be performed as per clinically determined indications. standard surgical pathology will be processed and reported per the institutional policy and procedures. a molecular/genomic profiling will be obtained using thyroseq v2 on the surgical specimen. all patients undergoing thyroid nodule work-up may be enrolled. the registry will collect patient demographic and clinical data, cytopathology reports, and surgical pathology reports and slides (if/when a review is required).

this is an open-ended prospective registry. the patients who were diagnosed with thyroid nodules will have a complete clinical and us evaluation. thyroid nodule biopsy indication and fna vs core biopsy choices will be made entirely on the clinical grounds, by the managing physicians. thyroid nodule biopsies may be performed at a participating medical or surgical endocrinology office. following standard cytologic examination a molecular testing using thyroseq will be performed. the biopsy results will be categorized according to bethesda scoring system. category i is non-diagnostic fna and will require a repeat fna. category ii is benign cytology, categories iii, iv and v are the indeterminate group, and category vi is malignant cytology. the fna analysis of registry patients will be collected under six groups. thyroseq molecular testing may be deferred if not felt needed following cytology. 1. cytology(benign) / thyroseq(-) 2. cytology(benign) / thyroseq(+) 3. cytology(indeterminate) / thyroseq(-) 4. cytology(indeterminate) / thyroseq(+) 5. cytology(malignant) / thyroseq(-) 6. cytology(malignant) / thyroseq(+). thyroid operation indication and lobectomy vs total thyroidectomy choices will be made entirely on the clinical grounds, by the managing physicians. the routine histopathology will be processed and reported as per the institutional protocols. the molecular testing of the preoperatively biopsied and intraoperatively and postoperatively identified lesions will be performed, as indicated. the registry is open to all interested physicians involved in thyroid patient care and interested in participating

Eligibility criteria:
inclusion criteria: * patients will be eligible for registry enrollment if they are undergoing thyroid nodule work-up. exclusion criteria: * patients will not be eligible for registry enrollment if a work-up beyond clinical evaluation is not indicated.
"mecpain", a new questionnaire to assess chronic pain mechanisms.

Conditions: Chronic Pain

Summary: validation of a new clinical questionnaire, called 'mecpain', including 12 questions, aimed at better defining the pathophysiological mechanisms of a chronic pain condition. this questionnaire includes 8 components/sub-components, reflecting various aspects of the 3 main mechanisms of chronic pain: nociceptive, neuropathic, nociplastic. a series of 240 patients with well-characterized chronic pain syndrome (for more than 6 months) of the nociceptive, neuropathic or nociplastic type will be recruited (80 patients per type of pain). the patients will be interviewed by a pain specialist to complete the 12 questions of the questionnaire during a routine visit in a pain center (chu grenobles alpes, grenoble, france or chu henri mondor, creteil, france). the scoring obtained with the 'mecpain' questionnaire will be compared to the presence of neuropathic pain assessed by two previously validated questionnaires, the 'dn4' and the 'paindetect' questionnaires. the expected outcome is a validation of the 'mecpain' questionnaire to provide a better understanding of the pathophysiological mechanisms relating to the presence of a chronic pain syndrome in a given patient.

the main objective of this study is to specify the physiopathological mechanisms of a chronic pain syndrome according to 5 main components (+ 3 "sensory" sub-components) reflecting various aspects of the 3 main mechanisms of chronic pain: nociceptive, neuropathic, nociplastic. a score will be assigned based on the answers to each of the 12 questions of the 'mecpain' questionnaire for each of the 8 components/sub-components mentioned above. 240 chronic pain patients will be included (in two centers), according to 3 categories: 80 patients with nociceptive pain (mechanical or inflammatory joint or spinal pain), 80 patients with neuropathic pain (painful peripheral neuropathy, neuralgia or radiculalgia, pain related with spinal cord or brain injury), and 80 patients with nociplastic pain (fibromyalgia, glossodynia, temporomandibular joint pain, irritable bowel syndrome, painful bladder syndrome).

Eligibility criteria:
inclusion criteria: * presence of a chronic pain syndrome (pain for more than 6 months); * well-characterized pain syndrome of the nociceptive, neuropathic or nociplastic type exclusion criteria: * opposition to the use of data obtained in the context of standard clinical follow-up.

Keywords: neuropathic pain nociplastic pain nociceptive pain chronic pain mechanisms
swallowing disorders in minimally consciousness patients (mcs)

Conditions: Swallowing Disorder; Traumatic Brain Injury

Summary: this study aimed to characterize swallowing disorders in minimally consciousness patients after brain traumatic injury.

after inclusion, the patients will underwent a videofluoroscopy and the wessex head injury matrix.

Eligibility criteria:
inclusion criteria: * legal representant signed * aged between 18 and 70 years * having a severe tbi (glasgow \< 8) * without counterindication to underwent a videofluoroscopy * could hold a setting position exclusion criteria: * pregnancy ongoing * having a pathologic al examination of ix, x, xii cranial nerve examination * massif faciale fracture * psychiatric illness * medical history of swallowing disorders
effectiveness of oculomotor training in parkinson's disease

Conditions: Parkinson Disease; Oculomotor; Disorder

Summary: parkinson's disease (pd) is a common neurodegenerative disorder which is characterized by both motor and non-motor symptoms and usually affects people aged 50 years or above. many studies showed eye movement deficits and visual changes in patients with pd. previous studies have also indicated that clinical eye movement training could enhance the functional performance of patients with various eye movement problems resulting from ocular and neurodegenerative diseases. in this study, we will investigate the effectiveness of eye movement training on dynamic vision and functional performance in pd patients with oculomotor deficits.


Eligibility criteria:
inclusion criteria: * parkinson's disease diagnosed by a neurologist or geriatrician with the range of stage 1 to 4 (hoehn and yahr classification) * able to speak and comprehend cantonese dialect * able to travel independently exclusion criteria: * any congenital eye problem (e.g. congenital strabismus or amblyopia in either eye) or any manifest eye diseases (e.g. macular degeneration, glaucoma, etc) * severe medical problems (e.g. stroke) * cognitive impairment (e.g. dementia) * presence of any psychiatric or neurological diseases (apart from parkinson's disease) or receiving of any psychoactive pharmacological treatment * receiving any medication that is known to affect eye movement and cognitive function * previous formal vision rehabilitation or oculomotor intervention

Keywords: parkinson disease oculomotor deficit oculomotor training dynamic vision
efficacy and safety of low dose rivaroxaban in patients with anterior myocardial infarction

Conditions: Patient With Anterior Myocardial Infarction

Summary: despite the use of guideline directed optimal medical therapy, 12% of patients with stable coronary heart disease and 18% of patients with recent acute coronary syndrome experience recurrent major adverse cardiovascular events 1. the risk of recurrent cardiovascular events may be related to persistent elevation of thrombin beyond the index event 2,3 which leads to progression of cardiovascular disease by inducing inflammation, endothelial dysfunction and thrombosis 4. in patients with coronary heart disease, vitamin k antagonists (vkas) and direct oral anticoagulants (doacs) have been explored as secondary prevention strategies and have shown cardiovascular benefits at the cost of higher bleeding events 5,6,7,8. howeverleft ventricular thrombus (lvt) usually appearswithin 1 month after st-segment elevation myocardial infarction (stemi) and mostlyforms after anterior stemi.9,11although the prevalenceof lvt after acute myocardial infarction hasdecreased dramatically in modern times due to the progress of reperfusion therapy, lvt incidence in patients with anterior stemi remains at 4% to 26%.10,12 it complicates acute myocardial infarction and is associated with a higher incidence of poor outcomes.9


Eligibility criteria:
inclusion criteria: * patients with anterior st-segment myocardial infarction on acetylsalicylic acid and clopidogrel exclusion criteria: 1. patients with liver cirrhosis. 2. patients with severe mitral stenosis . 3. patients with bleeding tendency (hasbled score ≥ 3) 4. severe renal impairment ( creatinine clearance \< 30 ml/min ). 5. patients with prosthetic valve . 6. patients on ticagrelor treatment 7. patients with atrial fibrillation
could cervical postural changes affect the long thoracic nerve electromyographic findings?

Conditions: Cervicalgia

Summary: this study investigates one of the mechanism factors of neck pain. cervical lordotic angle alterations affect the tension of serratus anterior muscle. expected result that the long thoracic nerve can be affected in this situation, and could be observed the functional changes of the nerve with serratus anterior electromyographic findings.

different methods exist in order to evaluate muscle function. for the neck pain, the most commonly used method by researchers and clinicians are spot radiography and surface electromyography (semg). radiographs can be used for the kyphotic angle or cervical lordotic angle measurements. parameters that can be studied by emg are amplitude, timing, conduction velocity, fatigability and characteristic frequencies/patterns. the long thoracic nerve innervates the serratus anterior muscle. this nerve arises from the anterior rami of three spinal nerve roots: the fifth, sixth, and seventh cervical nerves (c5-c7) the nerve descends through the cervicoaxillary canal behind (posterior to) the brachial plexus and the axillary artery and vein, resting on the outer surface of the serratus anterior. the serratus anterior electromyography, the needle can be inserted into the muscle superficially to the fourth to sixth rib in the medial or posterior axillary line. the usual nerve latency time is between 2.6-4 ms. in this study, the results of serratus anterior muscle emg activity and postural cervical angle alterations (lateral radiography) in patients with chronic mechanical neck pain will be compared with healthy volunteers without neck pain.

Eligibility criteria:
inclusion criteria: * patient whose age is \> to 18 years and \<40 yo * patient presenting a chronic neck pain (symptoms over 3 months) * no neurological deficit * asymptomatic volunteers (for control group) * obtaining the enlightened consent of the patient exclusion criteria: * patient having refused to sign his consent * patients whose age is \ 40 yo. * patients with neurologic deficits * patients presenting history of allergy * history of cervical spine surgery * patient presenting an anticoagulant or salicylated treatment which can not be interrupted. * pregnant woman. * patient with acute head and neck trauma * patient with a contra-indication to radiography. * patient with a psychiatric pathology preventing a clinical evaluation. * patient with contra-indication (cutaneous or different) to needle electromyography. * surgery contra-indication (cardiac failure, respiratory...) * patient without health coverage.

Keywords: neck pain cervical lordosis long thoracic nerve
hypoxia intolerance in preterm individuals

Conditions: Premature Birth; Hypoxia

Summary: reduced hypoxic ventilatory response (hvr) and systemic o2 saturation subsequently leading to blunted aerobic capacity as well as decreased overall physical and cognitive performance are the main physiological challenges faced by prematurely born individuals in hypobaric hypoxia (i.e. during high altitude sojourn). while these phenomena have been described previously, the underlying mechanisms are currently unresolved. given that the reduction in altitude-performance and its underlying mechanisms are not well understood, it is currently impossible to give evidence-based recommendation for altitude sojourns in this cohort. it is also of note, that even hypobaric hypoxia exposure during long-haul flights might be detrimental to well-being of pre-term born individuals. the present project aims to comprehensively investigate physiological responses to altitude/hypoxia during rest and exercise in prematurely born, but otherwise healthy adults. specifically, the investigators aim to elucidate the underlying mechanisms of the altered resting and exercise cardiovascular, respiratory, cerebral and hematological responses to hypoxia in prematurely born individuals. the obtained results from this cohort will be compared to the data from a control groups consisting of healthy, age and aerobic capacity-matched individuals born at full-term. while acute hypoxic effects will be the focus of the project's first phase, the researchers will test the effect of prolonged terrestrial (real) or simulated (normobaric hypoxia) altitude exposures in the second part. this phase will, in addition to the insight into the prolonged altitude acclimatization modulation in prematurely born individuals, also enable the potential differences between the effects of normobaric (simulated) and hypobaric (terrestrial) hypoxia in this cohort to be investigated.


Eligibility criteria:
inclusion criteria: * prematurely born (gestational age: ≤ 32 weeks; gestational weight ≤ 1500g) * full-term born * healthy individuals * male exclusion criteria: * presence of any medical risk factors to exercise and/or exposure to altitude * presence of any medical condition that would make the protocol unreasonably hazardous for the patient * smokers * exposure to altitude above 1000m in the last 2 months

Keywords: acclimatization altitude preterm birth cardiorespiratory cerebrovascular exercise
open-label study of cs-1008 for subjects with untreated and unresectable pancreatic cancer

Conditions: Pancreatic Cancer

Summary: phase 2 study to determine the efficacy and safety of cs-1008 when given with gemcitabine to subjects with previously untreated and unresectable (unable to be surgically removed) or metastatic (spread to other areas beyond the pancreas) pancreatic cancer.

primary objective: - to evaluate the efficacy of cs-1008 administered in combination with gemcitabine to chemotherapy naive subjects with unresectable or metastatic pancreatic cancer, based on the progression-free survival at 16 weeks. secondary objectives: * to evaluate the efficacy of cs-1008 administered in combination with gemcitabine on overall progression-free survival rate, objective response rate, duration of response, and overall survival. * to determine the pharmacokinetics of bip cs-1008 and dsc cs-1008. * to study potential biomarkers of cs-1008 activity * to assess possible human anti-human antibody formation after exposure to cs-1008 * to evaluate the safety profile of cs-1008 when administered in combination with gemcitabine to chemotherapy naive subjects with unresectable or metastatic pancreatic cancer.

Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed resectable or metastatic pancreatic cancer; not previously treated with chemotherapy; measurable disease; 18 years of age or older exclusion criteria: * anticipation of need for major surgery or radiation therapy during the study * heart disease exclusions: myocardial infarction or unstable angina within the past 6 months; severe or unstable angina pectoris within the past 6 months; coronary or peripheral artery bypass graft within the past 6 mo., etc. * clinically significant active infection or history of hiv * partial or complete bowel obstruction * poorly controlled psychiatric illness

Keywords: pancreatic cancer chemotherapy naive unresectable or metastatic pancreatic cancer cs1008 gemcitabine gemzar
cholestasis reversal: efficacy of iv fish oil

Conditions: Parenteral Nutrition Associated Liver Disease; Short Bowel Syndrome; Gastrointestinal Disease

Summary: the purpose of this study is to determine whether omegaven is effective in the treatment of parenteral nutrition associated liver disease (pnald).

the purpose of this study is to determine whether the omega-3 fatty acid emulsion (omegaven), when used in lieu of the conventional soy-based fat emulsion (intralipid), is effective in the treatment of parenteral nutrition associated liver disease (pnald).

Eligibility criteria:
inclusion criteria: 1. patients will be pn dependent (unable to meet nutritional needs solely by enteral nutrition) and are expected to require pn for at least another 30 days 2. patients considered eligible for study participation must have parenteral nutrition associated liver disease (pnald) as defined as a direct bilirubin of \> 2 mg/dl or currently on omegaven through another protocol. other causes of liver disease should be excluded. a liver biopsy is not necessary for treatment. 3. direct bilirubin \> 2.0 mg/dl or already on omegaven through another protocol 4. signed patient informed consent. 5. the patient must have utilized standard therapies to prevent the progression of his/her liver disease including surgical treatment, cyclic pn, avoiding overfeeding, reduction/removal of copper and manganese from pn, advancement of enteral feeding, and the use of ursodiol (i..e., actigall®). exclusion criteria: 1. pregnancy 2. other causes of chronic liver disease (hepatitis c, biliary atresia, and alpha 1 anti-trypsin deficiency). 3. enrollment in any other clinical trial involving an investigational agent (unless approved by the designated physicians on the multidisciplinary team) 4. the parent or guardian or child unwilling to provide consent or assent in rare instances, patients diagnosed with pnald may later be found to have liver disease due to other causes in addition to the use of pn (i.e., inborn errors of metabolism, viral infections ). such causes may not be known at the time of enrollment and will not preclude them from continuing in the study. for the sake of statistical analysis, however, these patients will be excluded although all data will be collected and reviewed.

Keywords: pnald omegaven parenteral nutrition associated liver disease cholestasis short bowel syndrome
point of care early infant diagnosis patient impact study

Conditions: HIV

Summary: in malawi, early infant hiv diagnosis (eid, i.e. hiv screening of infants under 18 months of age) is conducted using molecular diagnostics at central laboratories. however, test volumes are growing and many parts of the country do not have close or easy access to laboratories. test samples are transported over large distances and this can introduce testing delays, especially for patients in rural and remote areas of the country. there are growing numbers of high quality point-of-care (poc) diagnostic technologies available and there is increasing interest in using these technologies to alleviate critical testing needs. this protocol describes an observational study looking at the patient impact of implementing poc eid technologies within the routine standard of care at seven facilities.


Eligibility criteria:
inclusion criteria: * younger than 12 months of age * clinical or other indication for an eid test (screen or confirmation), such as birth to an hiv-positive mother exclusion criteria: * older than 12 months of age * serious medical conditions which would make testing dangerous for the infant, or disrupt the accuracy of normal laboratory analysis and its interpretation * already initiated art
comparative study of real-time ultrasound-ct fusion imaging and ultrasound-guided selective lumbar nerve root block

Conditions: Low Back Pain

Summary: the study is aimed at patients with low back and leg pain. the experimental group of patients underwent selective lumbar nerve root block puncture under real-time ultrasound-ct fusion imaging by sonographers, and the control group underwent puncture under the guidance of ultrasound alone by sonographers.

a total of 60 patients with low back and leg pain were randomly divided into two groups, 30 people in each group. patients in the experimental group underwent selective lumbar nerve root block puncture under the real-time ultrasound-ct fusion imaging of the sonographer, and the control group underwent puncture under the sole ultrasound guidance of the sonographer. this study was used to compare the difference between the effects of pure ultrasound guidance and ultrasound-ct fusion imaging guidance on selective lumbar nerve root block.

Eligibility criteria:
inclusion criteria: patients who need lumbar nerve root block treatment exclusion criteria: 1. tumor patients 2. patients who have had lumbar spine surgery before
mentored community gardening for individuals with skin cancer

Conditions: Melanoma; Cancer Survivorship; Skin Cancer; Basal Cell Carcinoma; Squamous Cell Carcinoma; Melanoma (Skin)

Summary: the investigators will conduct a single-arm pilot feasibility trial of mentored community gardening for melanoma survivors integrating dosimeters and accelerometers. harvest for health together arizona (h4h2-az) is an evidence-based program adapted for arid desert gardening that also addresses sun safety through group workshops and peer education. the primary aim is to evaluate adherence to the intervention.

in collaboration with banner health, university of arizona cancer center, community gardens of tucson, and uarizona pima county cooperative extension master gardeners, the investigators will conduct a pilot feasibility study of community gardening in melanoma survivors integrating uv sensors. harvest for health together arizona (h4h2-az) is an evidence-based program adapted for arid desert gardening that also addresses sun safety through experiential workshops and education. the investigators propose to evaluate adherence to and acceptability of the intervention. the investigators aim to see if h4h2-az may improve cancer preventive health behaviors (including diet, physical activity, energy balance, and uv protection) and quality of life among melanoma survivors.

Eligibility criteria:
inclusion criteria: * 18 years of age or older at their last birthday \& in good general health. * clinical diagnosis of skin cancer (including in situ). * has access to a phone or tablet with a camera and internet. * currently living in pima county arizona. * ability to understand and speak english. * ability to provide written informed consent document. * ability to physically participate in gardening activities (including kneeling, sitting, bending, and carrying up to 10 pounds) with or without the use of mobility assistive devices. exclusion criteria: * currently immunosuppressed by virtue of medication or disease. * has a diagnosed and uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.

Keywords: nutrition uv physical activity gardening