Kornimate/medical-research-clean huggingface dataset:
building community living labs in black communities to advance prostate health equity and reduce prostate cancer disparities in black men

Conditions: Prostate Carcinoma

Summary: this clinical trial the possibility of establishing a community living labs (collab) learning health system to facilitate access to prostate health risk, education, and assessment in the community with help (reach) services in black men and compares the impact to american legion posts with no collab set up at the individual and community levels. cancer is the second leading cause of death for black men and black men are less likely to receive prostate cancer screening. collab learning health system utilizes community health workers (chw) that are well-trained to form a bridge between communities and clinicians. in fact, black men who work with chw's typically have better access to health services, gain knowledge about cancer, cancer prevention, treatment and may have better overall health outcomes. establishing a collab learning health system at american legion posts may improve access to clinical trials and prostate cancer services in black men.

primary objectives: i. co-create real-life user centric collab learning health system at three american legion posts, compared to an american legion post with no collab set-up. american legion post 197 will serve as the hub and post 244 and post 194 as the spokes. ii. assess and evaluate the impact of the collab learning health systems compared to the comparison post at the individual and community levels. iii. explore the feasibility of replicating the collab learning health system in black communities nationally. outline: participants access collab learning health system to use any of the services at least twice monthly for up to 1 year.

Eligibility criteria:
inclusion criteria: * aims 1 and 3: participants must be one of the following key personnel: * community pi (n=1), * collab program manager (n=1) * collab site managers (n=3) * collab cab members (n=21) * 2 community health workers (chws) per post site (n=6) * aims 1 and 3: between the ages of 21 and 80. * aims 1 and 3: able to complete the survey in english. * aims 1 and 3: reside in the jacksonville, fl and/or surrounding counties. * aims 1 and 3: willing and able to consent to the study. * aim 2: black adult of any gender. * aim 2: must be between the ages of 30 and 80. * aim 2: able to speak english. * aim 2: reside in the jacksonville, fl and/or surrounding counties. * aim 2: willing and able to consent to the study. exclusion criteria: * aims 1 and 3: younger than 21years or older than 80 years. * aims 1 and 3: not a resident of ne florida. unwilling or unable to consent to the study. * aim 2: younger than 30 years or older than 80 years. * aim 2: not a resident of ne florida. * aim 2: unwilling or unable to consent to the study.
platelet-inhibitor drug trial in coronary angioplasty

Conditions: Angina Pectoris; Cardiovascular Diseases; Coronary Disease; Heart Diseases; Myocardial Ischemia

Summary: to determine the effectiveness of dipyridamole and aspirin in prevention of restenosis of the dilated lesion in patients who had undergone percutaneous transluminal coronary angioplasty (ptca). secondary aims were to determine the effectiveness of platelet inhibitor therapy in reducing the incidence of coronary events and the severity and incidence of angina.

background: by dilating coronary stenoses, ptca can relieve angina pectoris and improve exercise tolerance and left ventricular function. however, restenosis occurs in 20-30 percent of dilated stenoses within three to six months following ptca making it necessary to restrict patient activities, resume antianginal medications, repeat ptca, or perform coronary artery bypass surgery. balloon dilatation of the atherosclerotic lesion damages the endothelium, intima, and media of the artery. this may lead to restenosis via platelet deposition, mural thrombus formation, and intimal proliferation by mechanisms that appear similar to those causing aortocoronary vein graft (acvg) occlusions. it had been demonstrated that dipyridamole plus aspirin therapy suppressed these mechanisms of acvg occlusion in the animal model, prolonged a shortened platelet survival in patients with coronary artery disease, and reduced acvg occlusions in patients both early and late after the operation. thus, a trial of these drugs in patients undergoing ptca was a logical and necessary step to reduce the major shortcoming of the initially successful ptca therapy, namely the high rate of restenosis. design narrative: randomized, double-blind, fixed sample. patients were randomized to treatment with dipyridamole plus aspirin or placebo. the study completion date listed in this record was obtained from the query/view/report (qvr) system.

Eligibility criteria:
patients to age 80 with angina pectoris.
a study collecting blood samples from pregnant women to aid in the development of a noninvasive prenatal test

Conditions: Pregnancy

Summary: the purpose of this study is to collect whole blood samples from women with viable pregnancies of at least 10 weeks gestation (at any risk for fetal chromosomal anomaly) for future testing with an investigational noninvasive prenatal test(s) (nipts), and to establish clinical truth compared to a clinical reference standard.

this is a prospective, multi-center specimen collection study; each subject's treatment, management, or medical care will not be determined by the study protocol. women 18 years of age or older with a viable pregnancy of at least 10 weeks gestation will be enrolled. a whole blood sample will be collected from each subject. subjects will be followed until data or specimens used to establish the clinical reference standard are collected, and pregnancy outcome and birth information is collected (if applicable). if cytogenetic test results from standard-of-care procedures are not available and pregnancies end in live births, a neonatal buccal swab specimen will be collected. maternal specimens will be processed to plasma and stored for future testing with an investigational nipt(s). there will be no investigational nipt results nor centralized cma ldt results generated under this protocol. cytogenetic results from standard-of-care procedures and microarray results will be used to classify the clinical status of subjects according to the clinical reference standard.

Eligibility criteria:
inclusion criteria: * has a viable pregnancy of at least 10 weeks, 0 days gestation at the time of maternal specimen collection (singleton or multiple pregnancy acceptable), * be 18 years of age or older at enrollment, and * is willing and able to provide documentation of informed consent. exclusion criteria: * has a prior nipt result from the current pregnancy, * had an invasive prenatal diagnostic procedure (eg, cvs, amniocentesis) in the current pregnancy before maternal specimen collection, * has a history of transplant or malignancy, * had a transfusion of blood or blood components up to 8 weeks before maternal specimen collection, * had preimplantation genetic screening for the current pregnancy (for in vitro fertilization patients only), or * has already participated in the study (enrolled previously)
minimal invasive rehabilitation of tooth loss in the posterior segment (mize-s)

Conditions: Unsatisfactory or Defective Restoration of Tooth

Summary: tooth loss can be addressed by different rehabilitative strategies. implant-supported crowns and conventional bridges (fixed dental prostheses \[fdps\]) are well established treatment alternatives. implant therapy is sometimes impossible, however, because of patient-related risk factors or economic issues. in such cases therapy with an fdp requires extensive removal of tooth structure to provide enough space for the restoration and to ensure mechanical retention if the abutment teeth are sound. alternatives for rehabilitation requiring minor or no preparation of the anchoring teeth are desirable. resin-bonded bridges meet this demand for minimal invasiveness and have been used clinically successfully. sometimes, however, patients choose a conventional fdp over a resin-bonded one (rbfdp) for esthetic reasons since the adhesive wings, which are traditionally made of a cobalt-chromium alloy, might be exposed while speaking or smiling or account for a colour change of the abutment teeth. such patients profit from an all-ceramic rbfdp. today, the clinical performance of different all-ceramic rbfdp designs has not yet been evaluated under randomized controlled conditions. the aim of this pilot study is to calculate the sample size that allows us to accept the hypothesis that the two designs tested are similar regarding their clinical performance with adequate statistical power.


Eligibility criteria:
inclusion criteria: * missing second premolar, or first molar, or second molar * regular patient of the department of prosthodontics of the university hospital of heidelberg * willingness to return for recall examinations on a regular basis * written informed consent * abutment teeth are vital or sufficiently endodontically treated * abutment teeth are periodontally stable * abutment teeth have only little or no defects of the hardsubstances exclusion criteria: * pregnancy or breastfeeding * medically compromised condition not allowing for standard dental treatment * patient is not able to give written informed consent * alcohol or drug abuse * positive bruxism and parafunctions questionaire * bite-strip \> 2 * attrition score \> 3 * deep bite (angle class ii/2) * abutment tooth height \< 4mm * missing canine or first premolar * gap size \> 18 mm * untreated symptomatic periodontal or endodontic lesions * abutment tooth mobility \> grade i * known allergies to materials used in this study * poor dental hygiene * planned change of residency
mid-atlantic research group single-operator cholangioscopic assessment of biliary strictures

Conditions: Biliary Tract Neoplasms

Summary: the purpose of this study is to determine if cholangioscopically-directed biopsies provide a higher diagnostic yield for malignancy in the setting of indeterminate biliary strictures when compared to standard means of sampling.

biliary strictures in the absence of a mass are a clinical challenge, as current accepted means of sampling provide suboptimal accuracy. both biliary brushings for cytology and fluoroscopically-directed biopsies produce highly-variable results. endoscopic ultrasound with fine-needle aspiration has also been employed with variable results. an additional modality, using a single-operator cholangioscope during endoscopic retrograde cholangiopancreatography (ercp) to obtain cholangioscopically-directed biopsies offers promise in increasing the yield of sampling. initial observational studies have shown an improved diagnostic yield, but the technique has not been tested in a randomized, medical effectiveness study to better characterize its actual clinical impact. we aim to compare the technique of biopsy-on-biopsy derived sampling via single-operator cholangioscopy with standard fluoroscopically-directed biopsies and brushings in a pilot study. we also aim to perform a medical effectiveness study on the early use of single-operator cholangioscopically (soc) in the evaluation of undiagnosed biliary strictures.

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years * presence of indeterminate biliary strictures with clinical indications for ercp. strictures are considered indeterminate when evaluation including cross-sectional imaging is non-diagnostic. patients who have previously undergone ercp with sampling will be included, as well as those who have not previously undergone ercp. * strictures located above the intrapancreatic bile duct * the subject's physician determines and ercp is clinically indicated * able to provide informed consent exclusion criteria: * prior enrollment in the study or another study evaluating biliary strictures * presence of extrahepatic malignancy or previously-diagnosed hepatocellular carcinoma * pregnancy * at-risk populations including prisoners and mentally challenged * unwilling to provide informed consent * medically unfit to undergo ercp * history of liver transplant
prediction and testing of antigenic sites of the aids virus, htlv-iii recognized by t lymphocytes for the development of synthetic vaccines

Conditions: HIV Infections; Healthy

Summary: subjects are healthy adult volunteers either at high risk for hiv infection or already known to be seropositive, who will donate blood for in vitro tests of t-cell function and in vitro responses to synthetic peptides corresponding to sequences from hiv proteins.

subjects are healthy adult volunteers either at high risk for hiv infection or already known to be seropositive, who will donate blood for in vitro tests of t-cell function and in vitro responses to synthetic peptides corresponding to sequences from hiv proteins.

Eligibility criteria:
inclusion criteria for the at risk group will be a statement from the donor that he is an active homosexual or bisexual. homosexual donors must not have aids.

Keywords: blood donors epitopes hiv
post-market clinical follow-up (pmcf) study of the infinity-lock button system for acromioclavicular joint stabilisation

Conditions: Acromioclavicular; Dislocation

Summary: this is a post-market clinical follow-up study. it will verify the long-term safety and performance of the infinity-lock button system (ilbs) when used for acute and chronic dislocations of the acromioclavicular joint and used as described by the manufacturer's instructions.

this is a post-market clinical follow-up study. it will verify the long-term safety and performance of the infinity-lock button system (ilbs) when used for acute and chronic dislocations of the acromioclavicular joint and used as described by the manufacturer's instructions. the medical device (ilbs) in this study is already on the market and is manufactured by xiros ltd. the ilbs comprises of a polyester flexible tubular tape and a titanium button. the tape is used to secure the joint and the button is used to secure the tape into position. this study will collect data on patients who meet the entry criteria and receive the device; it will recruit patients from several clinical sites. all patients in the study will receive the ilbs, as it is a single armed study. the total length of the study is expected to be 4.5 years; this includes a recruitment period of approximately 18 months and a 3-year follow-up. a total of 58 subjects will be enrolled into the study. follow up is at 3 months, 6 months, 1,2 and 3 years.

Eligibility criteria:
inclusion criteria: * patient must be 16 years old or above. * patient is diagnosed with acute or chronic grade ill-vi acj dislocation. * patient is willing to participate in the study and have been informed of the nature of the study, agree to its follow-up and have provided written informed consent as approved by the research ethics committee (rec). exclusion criteria. * known hypersensitivity to implant materials. if the patient is suspected of having any foreign body sensitivity, appropriate tests should be made prior to implantation. * infections or any other structural or pathological condition of the bone or soft tissue (such as hyperlaxity) that would be expected to impair healing or secure fixation. * patients unable or unwilling to restrict activities to prescribed levels or follow a rehabilitation programme during the healing period. * skeletally immature patients are not suited as the infinity-lock™ button system will not elongate with growth. the use of this medical device and placement of hardware or implants must not bridge, disturb or disrupt the growth plate. * any other conditions or factors which in the opinion of the investigator may interfere with study conduct.
effect of sensory electrical stimulation on resting tremors in patients with parkinson's disease

Conditions: Parkinson Disease

Summary: parkinson's disease is one of the most prevalent motor disorders in the world . the disease is progressive and has no known treatment. in addition to a number of psychological and autonomic issues, the disease also cause movement abnormalities which are the most challenging problem because management is still limited by medication or traditional physiotherapy the most effective way to treat symptoms is through an interprofessional new modalities as sensory stimulation , this study will be the first of its type to measure the effect of sensory stimulation on static tremors. also, this study is the first of its type to make a continues treatment protocol for patient with static tremors. so the purpose of these study will to investigate the effect of sensory electrical stimulation on resting tremors in parkinson's patients.


Eligibility criteria:
inclusion criteria: * age between 45 and 60 * diagnosed with idiopathic parkinson's disease with magnetic resonance imaging of the brain * all the patients will have mild to moderate symptoms based on (the unified parkinson's disease rating scale updrs) ≥ 3 * static tremors have been present at the hand and wrist * absence of other disorders that cause similar symptoms like dystonia exclusion criteria: * history of hand trauma causes stiffness * presence of other neurological problems interferes with diagnosis as hemiplegic stroke * secondary parkinsonism (drug-induced or vascular ) which has very low tremor magnitude which can not be detected the patient has a severe visual problem that does not allow following the instructions. * the patient educational level does not allow for following the instructions.
wei nasal jet tube vs gastro laryngeal tube in endoscopic retrograde cholangiopancreatography

Conditions: Supraglottic Airway Efficiency; Airway Complication of Anesthesia; Airway Aspiration; Complication of Anesthesia; Esophagus Injury; Endoscopic Ergonomics; ERCP Airway Management; Bleeding Nose; Bronchospasm

Summary: the most common adverse event in endoscopic procedures is hypoxia. different airway devices have been investigated in the literature to prevent hypoxia. this study aimed to compare the efficacy and procedural performance of two different airway (glt and wnj) devices in ercp procedures.

ercp is a procedure that requires intolerable positioning, prolonged air insufflation, and deep levels of anesthesia. the procedure can be performed under general anesthesia or with deep sedation. it becomes more difficult to maintain airway patency in the prone position under deep sedation. clinicians prefer supraglottic airway devices developed for endoscopic procedures. glt requires a deeper level of anesthesia. wnj, on the other hand, can be tolerated with less depth levels of anesthesia. it has been reported in the literature that glt and wnj are effective in maintaining patent airway and preventing hypoxia in ercp procedures. however, both airway devices have not been compared for airway efficiency and ercp procedure condition. in this study, the investigators aimed to compare airway efficiency and procedure condition using glt and wnj.

Eligibility criteria:
inclusion criteria: * asa physical status 1-2 * elective procedures * body mass index 18.5 - 35 kg/m2 exclusion criteria: * high risk of pulmonary aspiration * pregnancy * anesthesic drug allergies * difficult airway or facial deformities * height \<155 cm * alcohol or narcotic drug usage * restrictive or obstructive pulmonary diseases * hepatic cardiac or renal failure * neurologic or cognitive deficiencies. * previous cervical surgery or cervical radiotherapy * previous esophagus surgery * psychotic problems

Keywords: wei nasal jet tube gastro-laryngeal tube ercp airway complication hipoxia
assessing force-velocity profile: an innovative approach to optimize cardiac rehabilitation in coronary patients

Conditions: Acute Coronary Syndrome

Summary: cardiac rehabilitation includes aerobic and anaerobic training adapted to cardiovascular pathology for which cardiac rehabilitation is prescribed. it is essential to adapt the content of these cardiac rehabilitation sessions to optimize aerobic and anaerobic performance and quality of life. improvement of the first ventilatory threshold is one of the main objectives since it illustrates the adaptation of the patient to submaximal exercise, typical of everyday life. the research laboratory "autonomous nervous system - epidemiology, physiology, engineering, health" (spa-epis) has an international expertise in training optimization in top-athletes. he have shown the importance of the relationship between the power-force-velocity profile and athletes performances.

in this sudy, each patient has a force and a velocity that can be optimized with training to achieve maximum power. this optimization can be evaluated through a force-velocity profile, measured from an only sprint on a cycloergometer. the hypothesis that force-velocity profile could be used in cardiac rehabilitation in coronary patients to induce a force-velocity balance adapted through personalized sessions and regular medical follow-up. this prospective, controlled, randomized and open label study will attempt to evaluate further the relevance of force or velocity training based on the initial force-velocity profile of coronary patients included in the cardiac rehabilitation program in the university hospital of saint-etienne.

Eligibility criteria:
inclusion criteria: * acute coronary syndrome treated within the last 6 months * medical revascularization (angioplasty ± stenting) or surgical (coronary artery bypass) * during initial effort test: maximum aerobic power≥ 60 watts for women and ≥ 80 watts for men * patient affiliated or beneficiary to social security * signed informed consent exclusion criteria: * significant co-morbidities limited practice of physical activity * inability to submit to medical monitoring of the program * patient deprived of liberty or patient under guardianship * pregnant woman

Keywords: cardiac rehabilitation physical activity force-velocity profile autonomic nervous system coronary artery disease
urdu version of parkinson's disease questionnaire: reliability and validity study

Conditions: Quality of Life

Summary: in the study , the researchers will investigate the reliability and validity of urdu version parkinson's disease questionnaire in pakistani population having parkinsonism

the study is aimed to translate and culturally adapt parkinson's disease questionnaire-39 into urdu language and to investigate validity and reliability of parkinson's disease questionnaire-39 in parkinson's diseased patient among pakistani population.the study will be a cross sectional survey in which non-probability purposive sampling technique will be used to enroll the participants into the study as per criteria. the results of the study will help to establish an understanding of validity and reliability of urdu version of parkinson's disease questionnaire-39 with quality of life of parkinson's disease patients in pakistani population having parkinson's disease. reliability of the scale will be checked through internal consistency and test-retest methods. cronbach's alpha value will be used to analyze internal consistency and for analyzing test-retest reliability an intraclass correlation coefficient with 195 patients will be used

Eligibility criteria:
inclusion criteria: 1. idiopathic parkinson's disease 2. minimum age of 40 years 3. minimum level of 5 years of education 4. a score equal to or greater than 23 on the mini-mental state examination 5. patient experiencing at least two of the three cardinal symptoms of idiopathic pairkinson disease (rigidity, resting tremor, and bradykinesia.) exclusion criteria: 1. patients with non-idiopathic parkinsonian variants 2. patients with a history of drug or alcohol abuse in the last two years 3. patients with unstable medical problems that may place the patient at increased risk or may interfere with the assessment or treatment of parkinson's 4. neurological operation on the brain within one year prior to study entry

Keywords: parkinson's disease questionnaire-39 parkinson's disease reliability validity urdu version