Kornimate/medical-research-clean huggingface dataset:
3 dimensional ultrasound in comparison to hysteroscopy in myomas

Conditions: Fibroid

Summary: • three-dimensional saline infusion sonohysterography (3d sis) was performed in all cases. a sterile cuscoe speculum was passed, the cervix visualized and cleaned with sterile chlorhexidine solution. a 3.3 mm soft plastic paediatric naso-gastric suction catheter was then passed through the cervix into the uterine cavity without grasping the cervix.

the speculum was removed and a 5 mhz transvaginal 3d ultrasound probe inserted into the vagina (voluson 730; kretztechnik, austria).

Eligibility criteria:
inclusion criteria: * • women between 20 and 60 years with abnormal uterine bleeding in form of heavy menstrual bleeding, irregular and heavy menstrual bleeding) diagnosed on non-enhanced two-dimensional ultrasonography with submucous fibroids. * absence of std, pid, active vaginal bleeding. exclusion criteria: * presence of general cause of abnormal uterine bleeding * history of drug use that can cause vaginal bleeding (anticoagulants, ocps, hrt) * history of recent hormonal treatment * high risk of undergoing hysteroscopy * vaginal, vulval causes of bleeding
application of digitized respiratory sounds for confirmation of the position of the balloon of endobronchial blockers

Conditions: Respiratory Sounds

Summary: this observation study is to evaluate the application of the spectral analysis and characteristic parameters of digitized respiratory sounds in the confirmation of the position of the balloon of endobronchial blockers

this is an observational study. we will recruit 30 patients who are scheduled for thoracic surgery under general anesthesia with tracheal intubation and need endobronchial blocker for unilateral lung ventilation during the operation. the standard procedures for confirming the position of the balloon of the endobronchial blocker, including the stethoscopic inspection and the fiberoptic examination, will be performed as routine practice. but in our study, besides the above routine practice, a microphone will be connected to the distal end of the stethoscope (the microphone will not contact directly with the patients) during the checking procedure to record the breathing sound into a digital computer as electronic files. these breathing sound files will be analyzed in a later time with spectral transformation and the characteristics are extracted. these digital signal processing results will be compared with the results of fibroptic exmination and the stethoscopic auscultation in the correct rate of diagnosing the position of the endobronchial balloon. the aim of this study is to examine the usefulness of the spectral parameters of the digitalized breathing sound in confirming the position of the endobronchial blocker balloon.

Eligibility criteria:
inclusion criteria: * thoracic disease patients who are scheduled for thoracic surgery and lung isolation requiring endobronchial blocker placement during the surgery * adult patients (no younger than 20 years old) exclusion criteria: * patients with significant thoracic diseases which result in abnormal respiratory sounds
a ketamine-assisted group therapy intervention for spanish-speaking adults with depression

Conditions: Depression

Summary: this is a pilot clinical trial to assess the feasibility, safety, and preliminary efficacy of ketamine-assisted group therapy for spanish-speaking adults with depression


Eligibility criteria:
inclusion criteria: 1. self-identifying latinx, spanish-speaking 2. adults 18-64 years 3. meet dsm-5 criteria for major depressive disorder as evaluated by study clinician 4. participants must have an mgb psychiatrist and primary care provider. exclusion criteria: 1. history of primary psychotic disorder, by history 2. history bipolar i disorder, by history 3. unstable complex ptsd, as assessed by study clinician 4. history of dissociative identity disorder 5. history of neurocognitive disorder 6. history of severe and/or recent substance use disorder, by history and as assessed by study clinician after clinical evaluation and interview 7. uncontrolled hypertension, tachycardia, or unstable cardiopulmonary disease, by history a. blood pressure on initial screen must be \<140/90 mmhg. 8. history of aortic dissection 9. history of myocardial infarction 10. history of aneurysm 11. history of hepatic impairment. 12. history of epilepsy 13. history of prior hypersensitivity to ketamine 14. body mass index greater than 35 15. body mass index less than 18.5 16. are pregnant, breastfeeding, or planning to become pregnant within 12 weeks of treatment completion 17. enrolled in other clinical trial for the treatment of depression or other behavioral health diagnosis 18. inability to provide consent.
comparative effects of buteyko exercise and corpse-pose technique on cardiac surgery patients

Conditions: Post-Cardiac Surgery Patients

Summary: open-heart surgeries such as coronary artery bypass grafting and valve replacements have been used to improve patient outcomes related to cardiac symptoms, prolongation of life, and health-related quality of life. recovery from cardiac surgery is not entirely determined by physical attributes and medical treatment, but social and psychological factors may also influence the process of postoperative short and long-term recovery. the objective of this study is to find out the comparative effects of buteyko exercise and corpse-pose technique on physical health and quality of life in post-cardiac surgery patients. this study will be a randomized controlled trial and will be conducted in faisalabad institute of cardiology after ethical approval. the study will be completed within the duration of 10 months after approval of synopsis. nonprobability convenience sampling technique will be used. the sample size of 46 patients will be taken: 25 post-cardiac surgery patients in each group with a 10% attrition rate. there will be two groups in this study one will be given with the buteyko breathing technique and other will be provided with corpse-pose technique. treatment protocol for both techniques will be 4 weeks with 3 sets per day. a pre assessment at week 1 and a final assessment at week 4 will be made by using sf-36 questionnaire. data will be analyzed on spss-25.


Eligibility criteria:
inclusion criteria: * stable post-op cardiac surgery patients (post-3 months) * both genders. * age 40-70. exclusion criteria: * patients on other medications. (corticosteroids) * patients with underlying severe medical conditions

Keywords: cardiac surgery buteyko breathing technique corpse pose yoga quality of life physical health short-form health survey sf-36
feasability and interest of screening for infantile pompe's diseases at birth

Conditions: Pompe's Disease

Summary: given the 100 fold increase of the incidence of pompe's disease in western french guiana, the objective of the present study is to implement systematic screening in newborns in french guiana in order to start treatment before the muscular and cardiac symptoms appear.


Eligibility criteria:
inclusion criteria: * newborn exclusion criteria: * parent refusal
cluster headache cortivazol injection (chci)

Conditions: Cluster Headache

Summary: the aim of tis study is to demonstrate the efficacy of cortivazol injections at the level of the greater occipital nerve to diminish the frequency of cluster headache (episodic or chronic) attacks during an active period. injections will be used in adjunct with oral verapamil.

cluster headache is characterized by unilateral attacks of severe periorbital pain accompanied by autonomic symptoms and restlessness. though patients may respond to the standard prophylactic treatment of verapamil, some are refractory and continue to suffer from numerous attacks, with a limit of two doses of subcutaneous sumatriptan per day. some patients also have contra-indications to standard prophylactic or acute treatments. other preventive treatments like systemic steroids, lithium and methysergide may cause significant side effects. we intend to show the efficacy of occipital nerve injections with cortivazol, in adjunct to verapamil, in cluster headache patients. we expect a diminution of attack frequency over two weeks, with a protocol of three injections separated by two or three days each. tolerance and safety will be examined.

Eligibility criteria:
inclusion criteria: * patient age, man or woman whose age is between 18 and 65 included * patient who signed a free express and informed consent * patient with cluster headache, episodic or chronic according to the criteria of international headache society (ichd-ii) * patient with more than two episodes of ch per day * patient with a normal medical examination exclusion criteria: * patient not affiliated with a social security scheme (or beneficiary entitled) * patient with another diagnosis ichd-ii,and being unable to differentiate ch attacks from its other cranial pain * patient of ch having started his episodic active period more than 30 days ago * patient with a contra-indication to verapamil * patient with a known allergy to cortivazol * patient with anticoagulant therapy or having a bleeding disorder * patient unable to complete the schedule crisis * patient non-compliant or unable to follow the research protocol * women without contraception, pregnant, or nursing

Keywords: cluster headache greater occipital nerve block cortivazol
effects of angiotensin receptor antagonist on prohibiting cardiovascular events on hemodialysis patients

Conditions: Cardiovascular Disease

Summary: cardiovascular disease is a leading cause of mortality in patients on hemodialysis therapy (hd), accounting for 30 to 50% of all death. although angiotensin receptor blockers (arbs) are effective for patients with diabetes and chronic kidney disease in reducing or preventing cardiovascular diseases, there has been no decisive study that demonstrated treatment with arbs is effective in patients on hd.


Eligibility criteria:
inclusion criteria: * 30 to 80 years of age * receiving hemodialysis at least 12 months and less than 5 years * pre-dialysis systolic blood pressure was more than 160 mmhg, or more than 150 mmhg if the patients received antihypertensive agents. exclusion criteria: * use of angiotensin receptor blocker or angiotensin converting enzyme inhibitor

Keywords: hemodialysis
functional magnetic resonance imaging for high throughput curietherapy planning in prostate cancer

Conditions: Prostate Cancer

Summary: merge the data of ultrasound with that of the anatomical and functional mri is necessary since the high dose rate curietherapy is carried out under ultrasound guidance. the investigators will recruit prostate cancer patients to evaluate the quality of the data, their sensitivity to exam conditions (patient position, volume of endorectal probe, gold grains implanted before intensity modulated radiotherapy , imrt) and to merge data from different sources with the purpose of estimating the opportunities of integration treatment plan for curietherapy broadband. the nuclear magnetic resonance imaging provides precise anatomical study, but also provides access to a functional approach to the tumor mapping of water diffusion coefficient (dw-mri), for dynamic imaging with injection contrast agent (dce-mri) and finally by spectroscopic imaging (irms). this multimodality imaging project is part of a multidisciplinary context, involving close collaboration between clinicians, medical physicists, and physicists of the teams participating in this project (institut gustave roussy and u2r2m-cierm hospital kremlin-bicetre).


Eligibility criteria:
inclusion criteria: patients with prostate cancer biopsy-proven, intermediate or high risk (according to d'amico classification), for which radiotherapy is indicated. * accepting the imaging tests. * age \<70 years. * informed consent signed. exclusion criteria: * mental pathology that can interfere with the proper conduct of the study; * claustrophobia; * severe heart or respiratory disorder that can make it difficult to achieve relatively long imaging tests * contraindications to magnetic resonance imaging (mri) 1. pacemaker, other electronic appliance (depending on model); 2. heart valve, intra-cranial clip aneurysm, cerebral ventricular bypass valve (depending on model); 3. intraocular metallic foreign bodies (chips), and other locations, according to the site to discuss. 4. metal tracheostomy cannula; 5. endovascular stent or vascular embolization coils placed within six weeks in advance; 6. the impediments to a long examination with spectroscopy sequence of ten to twenty minutes: major tremors, inability to lie more than 30 minutes; 7. local sources of magnetic distortion which is sensitive spectroscopic imaging: hip replacement, prostate biopsy older than six weeks.
rib removal and pain in partial nephrectomy

Conditions: Pain; Partial Nephrectomy; Kidney Cancer

Summary: in this study, the effect of rib removal on postoperative pain in kidney cancer patients undergoing retroperitoneal open partial nephrectomy with flank incision was investigated. for this purpose, vas score surveys were prepared for patients who underwent partial nephrectomy surgery in the early and late postoperative periods.


Eligibility criteria:
inclusion criteria: * patients aged over 18 years who underwent open renal surgery due to kidney cancer were included in the study. exclusion criteria: * patients with a preoperative (one day before surgery) vas score greater than 0, * those with additional known diseases that could cause pain (herniated disc, urinary stone disease, inflammatory bowel diseases, other intra-abdominal pathologies), * intraoperative complications that could cause postoperative pain, metastasis, positive surgical margins or peri-renal invasion, * those who underwent laparoscopic surgery or those who converted to open surgery after laparoscopic surgery, * patients that regularly used painkillers for other reasons, * patients whose ribs other than the 11th rib were removed were excluded from the study.

Keywords: rib removal partial nephrectomy pain renal cancer
patient outcomes with endoscopic versus open carpal tunnel release

Conditions: Carpal Tunnel Syndrome

Summary: although some surgeons prefer one technique rather than the other, both endoscopic and open carpal tunnel release procedures are accepted as standard of care surgeries to relieve carpal tunnel syndrome. the investigator's research is designed to evaluate the significant difference in patient satisfaction between endoscopically-released wrists and open-released wrists. the goal of the study is to compare the two techniques using the following criteria: 1. primary outcome: patient satisfaction via surveys used in prior publications 2. secondary outcome: length of time to return to work 3. secondary outcome: clinical data for recovery from carpal tunnel syndrome including a thorough physical exam and emg's 4. secondary outcome: complication rates


Eligibility criteria:
inclusion criteria: 1. patients between the ages of 18 and 75 2. documented clinical and electromyography (emg) proven carpal tunnel syndrome exclusion criteria: 1. recurrent carpal tunnel syndrome 2. inflammatory arthropathy 3. peripheral neuropathy 4. diabetes 5. \ 75 years old 6. pregnant at the time of enrollment
does a virtual program for pelvic pain improve pain and sexual outcomes in individuals with provoked vestibulodynia?

Conditions: Vulvodynia (Chronic Vulvar Pain); Vulvar Vestibulitis; Vestibulodynia; Provoked Vestibulodynia; Provoked Localized Vulvodynia

Summary: the goal of this clinical trial is to learn if a 3-month online pelvic health program works to improve pain and sexual wellbeing in adult women with chronic genital pain. the main research questions it aims to answer are: * how well does the program work to improve pain and sexual wellbeing? * how well does the program work to improve pain anxiety and pain interference? * how do participants rate their improvement after completing the program? * how satisfied are participants with the program? researchers will compare participants who receive the program right away to those who wait for the program. participants who receive the program right away will * progress through the program at their own pace * learn about pain science, do pelvic health exercises, and use information to be more mindful and less anxious about the pain * answer questions about their pain experiences and sexual wellbeing before and after the 3-month program, as well as 3 months after the end of the program * provide information about their experiences with the program and progress through the program during and after the program

the primary aim of the proposed single-centre randomized controlled trial is to examine the efficacy of a virtual multimodal 12-week program for individuals with provoked vestibulodynia (pvd, diagnosed by a healthcare provider) compared with a waitlist control group (i.e., participants who are on the waitlist to receive treatment). we hypothesize that participation in the program will result in greater improvements in our primary outcomes of pain and sexual wellbeing for persons with pvd immediately post-treatment and at 3-month follow-up compared to the control group. our secondary aim is to compare outcomes of the program versus control group on secondary measures of pain catastrophizing, pain self-efficacy, interference (on sexual life and life in general), perceived improvement, and treatment satisfaction. we hypothesize that participants in the program will report greater improvements in these outcomes compared to participants on the waitlist . we will also collect information on adverse events, progress through the program, and thoughts about the program.

Eligibility criteria:
inclusion criteria: * self-reported physician diagnosis of provoked vestibulodynia (pvd) * pvd duration of at least 3 months * pvd pain intensity rating of at least 3 on a scale from 0 (no pain) to 10 (extreme pain) * resides in north america (canada or the united states) * fluent in english exclusion criteria: * less than 18 years old * pregnancy or suspected pregnancy * breastfeeding * up to one year postpartum * physical or mental health conditions that significantly interfere with activities of daily living

Keywords: vulvodynia provoked vestibulodynia virtual pelvic health program pain and sexual wellbeing outcomes randomized controlled trial intervention
laparoscopic colorectal surgery for cancer- long term survival

Conditions: Colon Cancer

Summary: the purpose of this study is to determine the survival after laparoscopic colectomies due to carcinoma.

laparoscopic procedures for colorectal carcinoma are taking place in the modern era of surgery, it was not proven yet to show pure advantage over the open colectomies. these procedures require highly skilled stuff with long learning curve, financial sources,increasing operation length. this retrospective study intends to show that the outcome of the overall survival is better in laparoscopic patients. all data about patients who had laparoscopic colectomies due to carcinoma in surgery a department in souraski medical center was recorded prospectively since the operation day till discharge. the retrospective follow up will be collected from the outpatient clinic, the oncology clinic and by questionnare to the patients. we wish to show that patients who were operated laparoscopy have better survival, better quality of life postoperatively.

Eligibility criteria:
inclusion criteria: * adenocarcinoma of colon exclusion criteria: * non curative operation * non cancerous subjects
exercise in peritoneal dialysis patients (pdex)

Conditions: Peritoneal Dialysis; Kidney Failure, Chronic

Summary: patients with end-stage kidney disease (eskd) receiving peritoneal dialysis (pd) are physically inactive, resulting in poor physical function and reduced quality of life. the aim of this pilot trial was to test the study feasibility of a combined resistance and cardiovascular exercise program (recruitment and retention rates) and report adherence and adverse events. the intervention (i) group received monthly exercise physiologist consultations, exercise prescription (resistance and aerobic exercise program using exercise bands) and weekly phone calls over 12 weeks. control (c) group received normal care. feasibility outcomes were exercise adherence rates and adverse events. secondary measures included physical function measures and patient-reported outcome measures (proms)

patients with end-stage kidney disease (eskd) receiving peritoneal dialysis (pd) are physically inactive, resulting in poor physical function and reduced quality of life. combined resistance and cardiovascular exercise programs have been shown to be successful in hemodialysis patients but studies are limited in pd patients. the primary objectives of this pilot trial was to test the study feasibility of a combined resistance and cardiovascular exercise program (recruitment and retention rates) and report adherence and adverse events. secondary objectives were to calculate the sample size for detecting differences in the 30 second sit to stand test (sts30) and measure the effect on physical function and patient reported outcome measures (proms). methods: the 3-month parallel two-arm pilot trial took place in california, usa. all participants were peritoneal dialysis patients in a single center who met inclusion criteria were invited into a randomized controlled trial. recruitment was through face to face invitation following eligibility requirements. the intervention (i) group received monthly exercise physiologist consultations, exercise prescription (resistance and aerobic exercise program using exercise bands) and weekly phone calls over 12 weeks. control (c) group received normal care. feasibility outcomes were exercise adherence rates and adverse events. secondary physical function measures were change in i compared to the c group in sts30, pinch strength test (pst) and the 8 foot timed up and go test (8tug). proms were measured using the london evaluation of illness (levil) instrument. data collection was not blinded but statistical analysis was blinded.

Eligibility criteria:
inclusion criteria: * end-stage kidney disease * receiving peritoneal dialysis for greater than 6 weeks * approved by the center medical director exclusion criteria: * unable to understand english * previous major amputations * unable to ambulate independently * known to be pregnant

Keywords: exercise physical function patient reported outcomes