Kornimate/medical-research-clean huggingface dataset:
study of bexxar combined with external beam radiation therapy

Conditions: Lymphoma, Non-Hodgkin

Summary: the purpose of the study is to assess the response rate of patients with relapsed or refractory low-grade or transformed low-grade, cd20-positive, b-cell non-hodgkin's lymphoma to iodine-131 (i-131) tositumomab (bexxar) therapy plus local palliative radiation therapy (xrt).

response will be assessed on the basis of the presence or absence of measurable lesion ≥ 1.4 x 1.4 cm (operationally defined as ≥ 2.0 cm2) by radiographic evaluation or ≥ 1.0 cm in greatest diameter detected by palpation on physical exam

Eligibility criteria:
inclusion criteria * histologically confirmed low grade cd20+ b cell non-hodgkin lymphoma (nhl) patients who have relapsed after chemotherapy or are chemotherapy resistant and have one or more sites of disease measuring more than 5 cm. * the patients must have failed at least one chemotherapy regimen * no anticancer treatment for three weeks prior to study initiation (six weeks if rituximab, nitrosourea or mitomycin c) * fully recovered from all toxicities associated with prior surgery, radiation, chemotherapy or immunotherapy * an institutional review board- (irb)-approved signed informed consent * age 19 years or older * expected survival of at least 6 months * prestudy performance status of 0, 1 or 2 according to the world health organization (who) * absolute neutrophil count (anc) of at least 1,500/mm³ * platelet count at least 100,000/mm³ * hct \> 30% * hgb \> 9.0 gm * bilirubin ≤ 2.0 * creatinine ≤ 2.0 * bone marrow involvement with lymphoma less than 25% (bilateral bone marrow) within 6 weeks of enrollment * acceptable birth control method for men and women exclusion criteria * disease progression within 3 months of last chemotherapy * prior myeloablative therapies with bone marrow transplantation or peripheral stem cell rescue * platelet count less than 100,000/mm³ * hypocellular bone marrow (≤ 15% cellularity) * marked reduction in bone marrow precursors of one or more cell lines * history of failed stem cell collection * prior treatment with fludarabine * prior radioimmunotherapy * presence of central nervous system (cns) lymphoma * hiv or aids-related lymphoma * evidence of myelodysplasia on bone marrow biopsy * abnormal bone marrow cytogenetics * patients who have received prior external beam radiation therapy to more than 25% of active bone marrow * patients who have received filgrastim * sargramostim therapy within 3 weeks prior to treatment * presence of human anti-mouse antibody (hama) reactivity in patients with prior exposure to murine antibodies or proteins * serious nonmalignant disease or infection, which, in the opinion of the investigator and/or sponsor, would compromise other protocol objectives * another primary malignancy (other than squamous cell and basal cell cancer of the skin, in situ carcinoma of the cervix, or treated prostate cancer with stable prostate-specific antigen, psa) for which the patients has not been disease free for at least 3 years * major surgery, other than diagnostic surgery within 4 weeks * pleural effusion * pregnant * lactating
no excuses/sin buscar excusas intervention to reduce latino men's hiv risks

Conditions: HIV Infections

Summary: the overall goal of this study is to develop and evaluate a brief, video-based, group-level intervention designed to reduce sexual risk taking among culturally diverse english- and spanish-speaking latino men who have sex with men (msm).


Eligibility criteria:
inclusion criteria: * be between the ages of 18 - 49 * self-identify as latino or hispanic * speak english and/or spanish * reside in nyc and not plan to move in the next 3 months * have had 2 or more sex partners in the last 3 months * have had at least 1 male sex partner in the last 3 months * have engaged in unprotected anal intercourse with at least one male partner in the last 3 months * be hiv negative or not know their status exclusion criteria: * participated in a program (research or non-research) during the past 6 months where they have received hiv prevention education (e.g. an in-person or online group session, workshop, support group). * report being hiv-positive

Keywords: hiv seronegativity hiv risk behavior unprotected sex men who have sex with men gay latino unsafe sex high risk sex
diagnosis and treatment of sleep-disordered breathing in the homes of patients with transient ischemic attack

Conditions: Transient Ischemic Attack; Sleep Apnea

Summary: generalist physicians in the outpatient setting care for 80% of the 300,000 patients who have transient ischemic attacks (tia) annually in the united states. despite existing secondary prevention therapies, recurrent ischemic events are common following a tia. given the risk of poor outcomes and the important role of the generalist, new therapeutic approaches for patients with tia are needed that can be applied by generalists to outpatients. this research will develop and evaluate a new therapeutic approach that centers on the observations that sleep-disordered breathing is a risk factor for cerebrovascular and cardiovascular disease, is common in patients with cerebrovascular disease, and is associated with poor outcome following a stroke or tia. we posit that diagnosing and treating sleep-disordered breathing in the home of tia patients can improve cerebrovascular and cardiovascular outcomes. the primary aims are to determine in tia patients: 1) the prevalence of sleep-disordered breathing, 2) the feasibility of diagnosing and treating sleep-disordered breathing using an auto-titrating continuous positive airways pressure (auto-cpap) machine within 24-hours of tia symptom onset, 3) adherence to auto-cpap, and 4) the effect of auto-cpap on blood pressure. we will recruit 80 tia patients to be randomly assigned to either the intervention or the control groups. each patient in the intervention group will use an auto-cpap machine for up to 90 days and will then receive an unattended sleep study using a sleep monitor. each patient in the control group will receive two unattended sleep studies, one upon enrollment and another after 90 days.


Eligibility criteria:
inclusion criteria: transient ischemic attack - exclusion criteria:age \<45 years; respiratory distress or known sleep-disordered breathing; chronic obstructive pulmonary disease (copd) requiring oxygen; pregnancy; time from symptom onset to beginning of study intervention 72 hours; life expectancy \<6 months; cognitive impairment (mini-mental status exam\<20); inability to provide informed consent; inability to communicate in english; residence outside the greater new haven area; or any condition where the monitoring required by the study would constitute a risk to the patient or impair his or her care. -

Keywords: transient ischemic attack sleep apnea
peripheral metabolic function in chronic heart failure patients

Conditions: Chronic Heart Failure

Summary: exercise intolerance is a major limiting symptom in patients with chf. however the poor correlation between the hemodynamic parameters of left ventricular performance at rest and exercise performance has led to the concept that peripheral factors such as muscle perfusion and muscle metabolism play a role as determinants of exercise capacity.

the pathophysiology behind the breathlessness and fatigue experienced by chf patients during exercise remains unclear. recent evidence suggests that the peripheral skeletal muscle, which becomes abnormal in heart failure, is the source of afferent signals which disrupt normal patterns of cardiorespiratory control. when chf patients exercise, an inappropriately strong sympathetic response further limits exercise tolerance by evoking larger than normal increases in peripheral sympathetic activation at a faster rate than in healthy individuals. a consequence of this exacerbated sympathetic response may be the further sympathetic restraint of blood flow to the active skeletal muscles resulting in hypoperfusion of the muscle vascular bed and fatigue. small muscle mass exercise training increases muscle oxidative capacity and improves aerobic work capacity in chf patients. a range of studies is proposed here that will provide an integrative view of the mechanistic basis behind exercise intolerance in chf and relate the intramuscular metabolic status to the autonomic control of hemodynamics during exercise. an understanding of the mechanistic basis of the improved exercise tolerance with training, independent of improved resting cardiac function, will yield important information regarding the integrated control of blood flow and metabolic demand in chf and highlight the importance of maintaining the integrity of the peripheral musculature in chf.

Eligibility criteria:
inclusion criteria: * new york heart association (nyha) class ii - iii * ejection fraction \<35% * heart failure as a result of previous myocardial infarction * optimal treatment (ace-inhibitors, beta-blockers) * stable heart failure * patients with and without implantable cardioverter defibrillator (icd) exclusion criteria: * peripheral vascular disease with symptoms of atherosclerosis (intermittent claudication) * aneurysm in a. femoral * moderate to severe heart valve disease * moderate to severe chronic obstructive pulmonary disease (copd) with fev1 \<60% * heart failure patients with biventricular pacemaker (bvp) * serious heart rhythm disturbances (arrhythmias such as atrial fibrillation and frequent premature ventricular contractions) * myocardial infarction within the last month * unstable angina (angina pectoris) * renal failure (creatinine greater than 2.5 mg / dl) * severe systemic disease of the nervous system, pulmonary or other severe organ involvement * bmi\> 30 * pregnancy

Keywords: training one-legged exercise peripheral blood flow cardiac function muscle metaboreflex
effectiveness of dance therapy in fibromyalgia.

Conditions: Fibromyalgia

Summary: the purpose of this study is to analyze the effects of an intervention with dance on balance,movility, pain and sleep in patients with fibromyalgia in comparison to a control group that will have an educational intervention.

fibromyalgia is a chronic disease consisting of widespread pain, fatigue, sleep disturbances, and cognitive impairments, among other symptoms, which affect daily physical activity. the regular physical exercise improves the functional, physiological, and behavioral components of physical fitness. dance therapy seems to increase motivation and adherence to therapy, and can provide a real alternative to conventional exercise the experimental group will receive a dance program treatment . the control group will receive an educational intervention.

Eligibility criteria:
inclusion criteria: * being over 18 years of age until 64. * being diagnosed with fms in accordance with american college of rheumatology - acr exclusion criteria: * participants with diagnoses of other inflammatory rheumatic diseases, previous neurological or orthopedic diseases, * use aids for balance, hearing and visual problems. * cognitive impairment.

Keywords: balance pain tug dance
treatment of peri-implant mucositis by means of implant decontamination and modification of the implant supported-prosthesis

Conditions: Peri-implant Mucositis

Summary: to test the modification of the implant prosthesis, in order to facilitate access to biofilm control, in combination with decontamination of the implant surface by means of an ultrasonic device with a plastic tip and plastic curettes, in comparison with the decontamination of the implant surface by means of an ultrasonic device with a plastic tip and plastic curettes, and no modification of the implant prosthesis.


Eligibility criteria:
inclusion criteria: * (1) presence of, at least, one titanium implant exhibiting peri-implant mucositis, defined as bleeding on gentle probing (0.15 n) in at least one peri-implant site. (2) no signs of loss of supporting bone after initial bone remodelling. in cases where baseline radiograph is available, it will be used for comparison, otherwise a maximum of 2 mm of crestal bone loss will be accepted (5). (3) single tooth and bridgework restoration with an inappropriate prosthesis design or contour which difficult oral hygiene access (overcontoured prosthesis, prostheses presenting closed embrasures, an abrupt emergence profile or excessive buccal flanges). (4) presence of \>1 mm of keratinized peri-implant mucosa. (5) a good level of oral hygiene, defined as an o'leary et al. plaque index \<25% (16). (6) absence of systemic diseases that could influence the outcome of the therapy (i.e. controlled diabetes, with hba1c\<7, patients will be included). (7) non-smoker or light smoking status in smokers (\<10 cigarettes/day). exclusion criteria: * (1) untreated periodontal conditions. (2) pregnant or lactating women. (3) patients who received systemic antibiotics in the last 3 months. (4) patients who received treatment of pm in the past 3 months. (5) patients receiving corticoids or medications known to have effect on gingival growth i.e. calcium channel antagonists, immunosuppressants or antiepileptic drugs. in those cases diagnosed with peri-implantitis, individualized treatment will be provided, apart from the present study.
liposomal paclitaxel combined nedaplatin in treatment of advanced or recurrent esophageal carcinoma

Conditions: Esophageal Carcinoma

Summary: the purpose of this study is to evaluate the safety, tolerance and efficacy of liposomal paclitaxel with nedaplatin as first-line in patients with advanced or recurrent esophageal carcinoma

the purpose of this study is to evaluate the safety, tolerance and efficacy of liposomal paclitaxel with nedaplatin as first-line in patients with advanced or recurrent esophageal carcinoma.patients receive liposomal paclitaxel 175mg/m2 and nedaplatin 80mg/m2 every 21 days until the presence of progressive disease or unacceptable toxicity.

Eligibility criteria:
inclusion criteria: inclusion criteria: 1. histological confirmed advanced metastatic or recurrent esophageal cancer 2. age between 18 and 80 years 3. ecog performance status of 0 to 2 4. life expectancy ≥ 12 weeks 5. has evaluable disease by response evaluation criteria in solid tumors (recist) 6. at least one prior chemotherapy regimen 7. adequate bone marrow function as defined by absolute neutrophil count more than or equal to 2000/mm3 8. platelet count more than or equal to 100,000/mm3 and hemoglobin more than or equal to 8 g/dl 9. adequate renal function defined by creatinine less than or equal to 1.25 × upper limit of normal(uln) and creatinine clearance more than or equal to 60ml/min, 10. adequate liver function defined by bilirubin less than or equal to 1.0×uln aspartate transferase(ast) and alanine transferase(alt) less than or equal to 2.5 ×uln. exclusion criteria: 1. other primary malignancy 2. symptomatic central nervous system metastasis 3. pregnancy or lactation 4. cardiovascular events such as myocardial infarction in the previous 6 months or congestive heart failure 5. ongoing infection

Keywords: esophageal cancer nedaplatin liposomal paclitaxel
the use of cyproheptadine in pediatric feeding disorders

Conditions: Pediatric Feeding Disorder, Chronic; Avoidant Restrictive Food Intake Disorder

Summary: the goal of this clinical trial is to learn if cyproheptadine, an appetite stimulant, can improve eating habits in children with pediatric feeding disorders. pediatric feeding disorders is a broad term that describes disorders of eating-related behaviors that causes altered consumption of food and impairs physical or psychosocial health.


Eligibility criteria:
inclusion criteria: * any patient aged 2-6 years of age who presents to pediatric gastroenterology clinic with complaint of "poor weight gain, malnutrition, failure to thrive/weight faltering, picky eating, or feeding issues" who screens positive for a pediatric feeding disorder using the child eating disorder questionnaire (cebq) * age range: 2-6 years * english or spanish speaking exclusion criteria: * patients who are tube fed * patients who are overweight (bmi at 85th%tile or greater) * patients who have active symptoms from a diagnosis of a gi disorder (inflammatory bowel disease, eosinophilic esophagitis, gastritis) * patients actively undergoing behavioral feeding therapy

Keywords: cyproheptadine malnutrition
use of jet-injection in photodynamic therapy for basal cell carcinoma

Conditions: BCC; BCC - Basal Cell Carcinoma; Basal Cell Carcinoma; Basal Cell Cancer; Superficial Basal Cell Carcinoma; Nodular Basal Cell Carcinoma

Summary: the purpose of this study is to find out whether injecting ala into the skin with a jet-injection device and activating the drug with light is a safe treatment that causes few or mild side effects in people with basal cell carcinoma.


Eligibility criteria:
inclusion criteria: subjects who meet all of the following criteria are eligible to participate in this study * histologically-verified, previously untreated low-risk mixed superficial and nodular bcc(s) or nodular bcc(s) \< 1 cm in diameter on scalp, extremities, or trunk. * ≥ 18 years of age * owner of a smartphone (android or iphone). patients without a working smartphone will not be considered eligible for this study. * being able to download application on their phone * being able to take pictures of their treated bcc(s) (with or without assistance) * female subjects of childbearing potential must be confirmed not pregnant by a negative urine pregnancy test prior to trial treatment. (female subjects are considered of childbearing potential unless they have been hysterectomized or have undergone tubal ligation or have been post-menopausal for at least one year prior to the first visit) * legally competent, able to give verbal and written informed consent * subject in good general health and willing to participate comply with protocol requirements. * superficial and nodular bcc(s) exclusion criteria: subjects meeting any one of the following criteria are not eligible to participate in this study * high-risk bcc(s) (h area, \>1 cm in m area, or \>2 cm in l area) * bcc(s) subtype morpheaform * diagnosed with gorlin syndrome * receiving immunosuppressive medication * subjects with a known allergy to ala * individuals with other interfering skin diseases in the area of treatment * subjects with a tattoo in the treatment area which may interfere with or confound the evaluation of the study * subjects with a history of keloids which is deemed clinically relevant in the opinion of the investigator * lactating or pregnant women * patient who are taking prescription pain medications or can not stop otc pain medications.

Keywords: superficial bbc nodular bbc superficial basal cell carcinoma nodular basal cell carcinoma bcc basal cell carcinoma pdt treatment photodynamic therapy jet injection memorial sloan kettering cancer center 20-270
occupational distress in doctors: the effect of an induction programme

Conditions: Burnout, Professional; Anxiety; Grief; Adaptation, Psychological; Eating Behavior; Alcohol Drinking; Drug Use

Summary: background: over 39% of approximately 3,000 doctors (the british medical association quarterly survey, 2015) admitted to frequently feeling drained, exhausted, overloaded, tired, low and lacking energy. such occupational distress may link to psychological and physical difficulties in doctors and have negative outcomes for organization and patients. the aim of the current study is to investigate the impact of an induction programme on occupational distress of doctors. methods/design: doctors will be invited to take part in an online research. participants will be randomly assigned to the experimental and control groups. participants in the experimental groups will complete one of the induction topics (about stress at work). before and after an induction programme participants will be asked to fill in an online survey about their current occupational distress and organizational well-being. discussion: the investigators expect that doctors' psychological, physiological and organizational well-being will improve after an induction programme which should serve as a resource for better doctor's own health understanding.


Eligibility criteria:
inclusion criteria: * medical doctors across all specialties and professional grades who have a regular contact with patients and works in the united kingdom.

Keywords: burnout psychiatric morbidity anxiety grief alcohol and drug use
whole body diffusion mri for non-invasive lesion detection and therapy follow-up: study with patients with gastro-intestinal tumors

Conditions: Gastro-intestinal Tumor; Accurate Staging; Whole-body Diffusion Weighted MRI; Non-invasive

Summary: the aim of the study is to assess the value of whole body diffusion weighted mr imaging (wb-dwi) as a non-invasive method. on one hand for pretreatment lesion detection and post-therapeutic tumor recurrence but also for early therapy monitoring with the intention to early identify patients with a poor tumor response. our research group demonstrated that this technique is accurate in patients with head and neck cancer it could differentiate between viable tumor tissue and inflammatory or necrotic tissue at variable time points after completion of radiotherapy. in the literature it is stated that dwi can also predict the response to chemotherapeutic therapy. this is only true for focal mri images (eg only in liver). this study aims to determine whether the whole body technique can efficiently be used because the distribution of metastases is systemic. the study includes two phases: in a first phase, a baseline study will be conducted; all possible injury types will be gathered to determine the variability in signal characteristics to finally determine appropriate thresholds to differentiate between benign and malignant lesions. this should allow us later on to perform prospective studies. in a second phase, different applications such as: * pretherapeutic staging * detection of post-therapy recurrence * early evaluation of systemic cytotoxic therapy. the results of the dw-mri will be compared with those of pet, ct and conventional mri which are now routinely performed for the diagnosis of colorectal tumors. the scans will be performed in a group of patients on a 3 tesla mr system. this system is fully approved by the european and american standards and the patients will not be exposed to radiation or contrast agents. in principle, all patients treated for gastrointestinal cancer were included after informed consent from the patient. this study is important to investigate whether dwi is accurate in the pre-therapeutic injury detection and staging of gastrointestinal tumors compared with pet / ct and dwi. in addition it is important to predict the outcome after therapy.


Eligibility criteria:
inclusion criteria: * in principle, all patients treated for gastrointestinal tumors will be included (only with the permission (informed consent) of the patient) exclusion criteria: * in case of a known contraindication for mri (eg pacemaker), the patient will not be admitted to the study.

Keywords: gastro-intestinal tumor accurate staging whole-body diffusion weighted mri non-invasive
comparison of implant positioning with robotic aided surgery and traditional jig positioning in total knee arthroplasty

Conditions: Knee Arthritis

Summary: the purpose of this study is to compare the outcomes and accuracy of implant positioning in robotic assisted total knee arthroplasty with traditional manually instrumented total knee arthroplasty.


Eligibility criteria:
inclusion criteria: * patients who have knee pain and are candidates for total knee arthroplasty * patients able to consent to be included in the study exclusion criteria: * patients with previous total or partial knee arthroplasty in need of revision surgery * patients unable to or unwilling to undergo post-operative ct scans after understanding the risks and benefits