Kornimate/medical-research-clean huggingface dataset:
efficacy of the memory motivation (memo) web application training

Conditions: Neurocognitive Disorders

Summary: memory, attentional, and behavioural symptoms are the clinical hallmarks of neurocognitive disorders (ncd) such as alzheimer's disease and related disorders. the world health organisation (who) guidelines for risk reduction of cognitive decline and dementia indicate that cognitive training may be offered to older adults with normal cognition and with mild cognitive impairment to reduce the risk of cognitive decline and/or dementia. the use of information and communication technologies (ict) in the health domain is progressively expanding. the alzheimer innovation association have developed memo (memory motivation) a free web application that can be used at home by patients. the objective of the present study was to assess the effectiveness of employing the memo platform on cognitive performance in patients suffering from ncd.

the objective of this study is to evaluate the effectiveness of the memo cognitive training exercise platform in patients suffering from neurocognitive disorders. these exercises ,have been developed by the association innovation alzheimer and the cobtek research team, located with the nice memory center at the institut claude pompidou. memo can be used freely at home by patients. more specifically, it is a randomized controlled study that aims to compare the evolution of activities cognition and behavior between patients not using these exercises, and patients using these exercises for 12 weeks, 4 sessions per week.

Eligibility criteria:
inclusion criteria: * outpatient consulting the memory center * older than 60 years old * mini mental state examination score (mmse) between 16 and 28 / 30 * met the dsm 5 diagnoses of mild neurocognitive disorders (mild ncd) or major neurocognitive disorders (major ncd). exclusion criteria: * patients not able to read and write french * presence of a hearing or major visual impairment * a history of premorbid mental retardation * had already used the memo application * were presently involved in structured memory training activities.

Keywords: cognition motivation technology non pharmacological intervention
safety and efficacy of daptomycin for the treatment of complicated skin and skin-structure infections

Conditions: Staphylococcal Skin Infections

Summary: this study will evaluate the safety and efficacy of daptomycin against complicated skin and skin-structure infections in adults


Eligibility criteria:
inclusion criteria: * subjects with a diagnosis of complicated skin and skin-structure infections (cssti) defined as infection normally requiring surgical/local debridement of sufficient severity to warrant hospitalization and intravenous antimicrobial treatment * infection to be due to gram-positive bacteria * hospitalized subjects * written informed consent * female patients of childbearing potential must have a negative pregnancy test urine or serum at baseline and must use effective contraception throughout the study period. exclusion criteria: * complicated skin and skin-structure infections of the following categories: * infected burns * severely impaired arterial blood supply * decubitus ulcers * infected diabetic foot ulcers associated with osteomyelitis * infected human or animal bites * perirectal abscess * necrotising fasciitis or gangrene * infections expected to require more than 14 days of intravenous antimicrobial therapy * skin and/or skin structure infection that can be treated by surgery alone * infections associated with a permanent prosthetic device that will not be removed within 2 days of study enrollment * uncomplicated skin or soft tissue infection * documented bacteremia at baseline * concomitant infection nearby the site of infection at baseline, potentially interfering with the evaluations * hospitalization for conditions related to rhabdomyolysis * human immunodeficiency virus (hiv) with cluster of differentiation (cd) \< 200 or \< 14% * immune function alterations * lack of sufficient purulent material for culture and gram test * systemic or local antibiotic administration with known anti-gram positive activity in the preceding 48 hours * complicated skin and soft tissue infections (cssti) known or believed to be related to fungal, parasitic or viral infection * pneumonia * local or systemic known or suspected allergy to daptomycin * creatinine clearance \< 30 ml/min * severe liver damage (child-pugh class c) or alanine transaminase (alt) and/or aspartate aminotransferase (ast) \> 3 x upper limit of normal (uln) and/or bilirubin \> 1.5 x uln * use of any experimental drugs in the preceding 30 days * severe medical conditions that in the investigator's opinion could counter indicate participation in the study

Keywords: complicated skin and skin-structure infections, daptomycin, mrsa, diabetic foot, abscess, cellulitis complicated skin and skin-structure infections
retinal vascular network and obstructive sleep apnea

Conditions: Obstructive Sleep Apnea Syndrome

Summary: obstructive sleep apnea syndrome (osa) is thought to lead to systemic vascular lesions that may be preceded by early microvascular lesions in the eyes and in particular in the retina. the improvement of ophthalmological imaging techniques by octangiography allows a precise non-invasive study of the retinal microvascular network. this new rapid and non-invasive retinal imaging tool could reveal micro-vascular lesions related to osa. to the investigator's knowledge, this would be the first oct-angiography description of a cohort of patients with osa. if these results are confirmed, it would be interesting to study the correlation between these micro-vascular lesions and the cardiovascular risk of his patients.


Eligibility criteria:
inclusion criteria: * person who has given oral consent * person who can be followed throughout the study * adult patient group: - patient seen in sleep apnea screening consultation by a pulmonologist and referred for polysomnography diagnosis of osa control group: - person initially without obstructive sleep apnea syndrome exclusion criteria: * a person who is not affiliated to or not a beneficiary of the national health insurance system * person subject to a measure of legal protection (curatorship, guardianship) * person subject to a safeguard of justice * pregnant, parturient or breastfeeding woman * adult incapable or unable to consent * person with a contraindication to tropicamide or neosynephrine * person with a history of eye disease affecting ocular circulation (examples: acute anterior ischemic optic neuropathy, retinal central artery occlusion, retinal central vein occlusion, diabetic retinopathy, glaucoma, uncontrolled hypertonia, amd, severe myopia...) control group: * person with a history of chronic lung problems (e.g. copd, chronic respiratory failure, etc.) * person with at least one of the following risk factors for obstructive sleep apnea syndrome: * obesity with imc≥30 * alcohol consumption \> 3 glasses per day exclusion criteria: positive result in one of the 3 self-questionnaires
a survey on blood transfusions in major artrhoplasty operations

Conditions: Arthropathy of Hip; Arthropathy of Knee

Summary: the rate of hip, knee arthroplasties and their revision are increasing every year. the incidence of blood transfusion in these operations are reported 18%, 68%, and 39%, 67%, respectively. blood transfusion is known to increase the risk of pulmonary, septic, wound and thromboembolic complications and is related to mortality. restrictive transfusion protocols has cost-effective results in terms of reducing these complications, promoting early discharge and reduced frequency of re-admission. within this context, we aimed to evaluate the transfusion practice in our hospital, define the transfusion indicators and compare the transfused and non transfused patients in terms of recovery.

after obtaining ethical approval patients undergoing hip or knee arthroplasty or revision arthroplasty will be included in this prospective observational study. patient characteristics (age , gender, body mass index, asa physical status, anticoagulant medication) preoperative: hemoglobin, hematocrit, platelet, inr, aptt, pt values, the precence of preoperative anemia, anemia treatment modalities will be recorded. intraopreative: type and duration of surgery, anesthesia method, monitoring methods used, the amount of intraoprative adminestred fluids (crystalloid-colloid), amount of hemorrhage postoperative: hemoglobin-hematocrit-platelet leve the amount of blood transfusion and the product used (erythrocyte suspension, fresh frozen plasma, thrombocyte-fibrinogen-factor concentration-cryoprecipitate-other ) hemoglobin-hematocrit-platelet level before and after transfusion indications for transfusion; hemoglobin threshold / physiological transfusion indicator; tachycardia, hypotension, low flow rate, desaturation, low svo2, inotropic requirement, etc. / comorbidities / monitorisation findings, other, discharge time of patients early upright position (postoperative 2nd day), information on walking capacities (tug - the time up and go test) will be recorded and compared between transfused and non-transfused patients

Eligibility criteria:
inclusion criteria: * patients undergoing major atrhroplasty exclusion criteria: * pediatric patients
efficacy of a brief nightmare treatment for veterans

Conditions: Sleep Disorders; PTSD; Suicide

Summary: the purpose of this study is to find out what effects exposure, rescripting, and relaxation therapy (errt) has on nightmares and associated problems in veterans.

the purpose of the proposed pilot study is to extend previous findings regarding the impact of a brief cognitive behavioral treatment for chronic nightmares by examining the emotional, cognitive, behavioral, and health-related changes following treatment. experiencing a traumatic event may initiate or exacerbate the occurrence of nightmares. indeed, sleep disturbance, including nightmares, is considered a hallmark of posttraumatic stress disorder (ptsd). nightmares have been related to a variety of factors including stress, medications, trauma, and substance use. among veterans, especially combat veterans or those reporting sexual assaults, symptoms of traumatic stress and nightmares are extremely common. few studies have investigated the efficacy of nightmare treatment in a veteran population, and the impact of nightmare treatment on suicidal ideation has never been assessed. imagery rehearsal treatment (irt) has received increased attention in the past decade for use with chronic nightmares. studies suggest that the treatment is promising for the reduction of frequency and intensity of chronic nightmares in trauma exposed persons and may have a generalized impact on symptoms of posttraumatic stress disorder and depression and quality/quantity of sleep, although there is mixed evidence for sleep improvement among veterans. the principal investigator has completed two randomized controlled trials of a modified version of irt, exposure, rescripting, and relaxation treatment (errt) and is currently conducting a third randomized controlled trial (davis, 2008; davis \& wright, 2007). the current randomized controlled trial is comparing errt to an active treatment (relaxation). results demonstrated positive treatment response. although these trials have included some veteran participants, veterans have not been studied as a group using this protocol. the purpose of this prospective study is to conduct a pre- and post-treatment comparison of suicidal ideation and posttraumatic, depressive, and health symptoms in a single group of veterans.

Eligibility criteria:
inclusion criteria: veteran/military, 18+ years old, english proficiency, nightmares once per week, exposure to a criterion a traumatic event - exclusion criteria: under 18, psychotic illness, mental retardation, imminent suicidal intent -

Keywords: nightmare ptsd posttraumatic stress disorder suicide exposure relaxation rescription therapy sleep
confocal endomicroscopy detection of gastric preneoplasia and neoplasia

Conditions: Gastric Intestinal Metaplasia

Summary: this is a prospective randomised study investigating the use of chromoendoscopy and confocal laser endomicroscopy for the detection of preneoplastic neoplasm in patients at high-risk of gastric cancer.

this is a prospective randomised study investigating the use of chromoendoscopy and confocal laser endomicroscopy for the detection of preneoplastic neoplasm in patients at high-risk of gastric cancer. patients are randomised to undergo upper endoscopy using either confocal laser endomicroscopy or standard whitelight endoscopy to investigate for gastric preneoplastic and neoplastic lesions.results are compared to histopathologic diagnosis made on biopsies obtained during endoscopy.

Eligibility criteria:
inclusion criteria: 1. the subject is chinese 2. the subject is greater than 50 years of age 3. the subject satisfies one or more of the following criteria: * has (had) a history of dyspepsia of at least 4 weeks or more. dyspeptic symptoms include bloating, epigastric discomfort and early satiety * has a family history of gastric cancer * has a medical condition for which an ogd is indicated. 4. the subject must have personally signed and dated the patient informed consent form indicating that he/she has been informed of all pertinent aspects of the study. 5. the subject must be willing and able to comply with scheduled visits and other study procedures exclusion criteria: 1. the subject who has bleeding disorders, such as haemophilia, in whom biopsies are contraindicated. 2. the subject with liver cirrhosis. 3. the subject with previous total or partial gastrectomy. 4. the subject with severe co-morbid illness, such as end-stage renal failure (esrf), congestive cardiac failure (ccf), severe osteoarthritis (oa) and rheumatoid arthritis (ra) requiring long term non-steroidal anti-inflammatory drug (nsaid) therapy. 5. the subject has other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may interfere with the interpretation of study results and in the judgment of the investigator would make the subject unsuitable for entry into the study. 6. the subject is currently on anti-coagulant therapy such as warfarin. patients on aspirin, ticlopidine and clopidogrel must undergo a one-week washout period before enroling in the study. 7. the subject has a history of bronchial asthma, or a known allergy to fluorescein. 8. the subject is unwilling or unable to provide signed informed consent.

Keywords: intestinal metaplasia, gastric cancer
epidermal adhesive sensors to enhance continuous glucose measurement in patients with diabetes: the ease study

Conditions: Diabetes Mellitus

Summary: self-testing of glucose by patients living with diabetes mellitus (dm) involves needles, which can cause discomfort or inconvenience; these and other factors can lead to decreased willingness to perform these checks that are vital to dm management. while technology has evolved, a needle-free glucose monitoring device is currently not available. the investigators are studying a glucose sensor that adheres to the skin, similarly to a temporary tattoo. this sensor can now obtain continuous readings. as it has not yet been tested in individuals with dm, this study will examine its accuracy and acceptability in these patients. results from this clinical trial could serve as the basis for further development of a non-invasive, wearable glucose sensor that can provide measurements of glucose levels continuously.


Eligibility criteria:
inclusion criteria: * an existing diagnosis of diabetes mellitus, either t1dm or t2dm, or any other type or etiology of diabetes * ability to provide informed consent for participation. exclusion criteria: * individuals without diabetes * those who cannot speak or read english. we are limiting participation to those who read and speak english, as this is a pilot study of a small number of participants, that will very unlikely offer the prospect of direct benefit from participating. * individuals who have frequent hypoglycemia, hypoglycemia unawareness, or who are at high risk for hypoglycemia.
efficacy of psychotherapy for improving quality of life in patients with hypertrophic cardiomyopathy and depression

Conditions: Hypertrophic Cardiomyopathy; Depression; Anxiety; Psychotherapy

Summary: a study to evaluate the efficacy of psychotherapy for easing the cardiac symptoms and improving and quality of life in patients with hypertrophic cardiomyopathy accompanied with depression

this study will use a 8 week parallel group design. 100 patients diagnosed as hypertrophic cardiomyopathy accompanied with depression will be into experimental group and control group. the experimental group received 8 times of psychological treatments for once each week; the control group did not receive any antidepressant treatment. follow-up assessments will be performed at baseline, week 4 and 8.

Eligibility criteria:
inclusion criteria: * diagnosed as hypertrophic cardiomyopathy; * diagnosed as depression; exclusion criteria: * patients with left ventricular ejection fraction (ef) ≦ 30%; * renal dysfunction with serum creatinine ≧451umol/l; * severe heart failure and new york heart association (nyha) heart failure grade iii; * combine with any type of malignant tumor; * combine with other serious mental illnesses such as bipolar disorder, schizophrenia, schizophrenia-like illness, severe dementia, etc.; * have received medication of antidepressant or psychotherapy; * patients with major depression; patients with a serious risk of suicide or have had suicide attempts; * pregnant women and lactating women, or women who are planning to become pregnant or breastfeeding during the study period; * other circumstances in which the researcher judges that it is not suitable as a research object.
pilot study for the norcapital trial

Conditions: Chronic Fatigue Syndrome

Summary: the aim of this pilot study for the norcapital trial is to investigate the feasibility and safety of the drug clonidine in adolescent chronic fatigue syndrome (cfs). specifically, the investigators wanted to assess appropriate dosage in relation to a) plasma concentration levels of clonidine, b) orthostatic cardiovascular responses (the pulse and blood pressure responses when rising up), and c) reports of possible adverse effects. a possible beneficial effect of clonidine in adolescent cfs will be investigated in norcapital, which is a randomized, placebo-controlled, double blind trial.


Eligibility criteria:
inclusion criteria: * persisting or constantly relapsing fatigue lasting 3 months or more * functional disability resulting from fatigue to a degree that prevent normal school attendance * age between 12 and 19 years exclusion criteria: * another disease process or current demanding life event that might explain the fatigue * another chronic disease * permanent use of drugs * permanently bed-ridden * positive pregnancy test * supine systolic blood pressure (sbp) \< 85 mm hg * fall in spb upon standing \> 30 mm hg * supine hr \< 50 beats/min * abnormal ecg

Keywords: adolescents
botulinum toxin injection to prevent ventricular arrhythmias

Conditions: Symptomatic Ventricular Asystolia; Ventricular Tachycardia

Summary: the aim of this prospective non-randomized study was to assess the efficacy and safety of endomyocardial botulinum toxin injection in left ventricle for preventing ventricular arrhythmias.


Eligibility criteria:
inclusion criteria: * symptomatic ventricular arrhythmias * drug-resistance * unsuccessful one or more ablation procedure with future unreasonable tries exclusion criteria: * previous heart surgery and af ablation procedure * emergency cabg * unstable angina or heart failure * use antiarrhythmic drugs within 5 elimination half-lives of the drug (or within 2 months for amiodarone) * requiring concomitant valve surgery * left ventricle ejection fraction \<35% * unwillingness to participate
outcomes in uk acs patients prescribed ticagrelor

Conditions: Acute Coronary Syndrome

Summary: cohort study using data from clinical practice research datalink (cprd). the study cohort includes all patients who received at least one prescription for ticagrelor for the first time between december 2010 and march 2015, following acs. patient baseline characteristics will be described: (age, gender, body mass index, smoking status, sociodemographic status), type of acs and interventions, cv history and comorbidities, bleeding and respiratory history. the following outcomes will be examined: incidence of vascular events (composite mi, stroke, vascular death, specific vascular event and all cause death), incidence of bleeding and incidence of dysponea. time to event for vascular events, bleeding and dyspnoea.


Eligibility criteria:
inclusion criteria: * first prescription (index date) for ticagrelor between dec 2010 and mar 2015 * at least 12 months history in database prior to first ticagrelor prescription * linkage to hospital episode statistics (hes) * acute coronary syndrome (acs) event in the three months prior to and including the index date exclusion criteria: primary care prescription for clopidogrel or prasugrel between the acs date and the index date
follow-up gene therapy trial for the treatment of x-linked retinitis pigmentosa associated with variants in the rpgr gene

Conditions: X-Linked Retinitis Pigmentosa

Summary: a clinical trial of aav5-hrkp.rpgr vector for participants with x-linked retinitis pigmentosa (xlrp)


Eligibility criteria:
inclusion criteria: * male or female, 3 years of age or older, has xlrp confirmed by a retinal specialist and has a predicted disease-causing sequence variant in rpgr confirmed by an accredited laboratory. exclusion criteria: * none