Kornimate/medical-research-clean huggingface dataset:
pre-procedural 3dct versus angiography guided pci for ostial right coronary artery lesions

Conditions: Coronary Artery Disease

Summary: even with second generation drug eluting stents, rates of target lesion failure (tlf) for aorto-ostial rca lesions remain high \[3yrs tlf 14.2%\]. retrospective studies show that stent underexpansion and geographical stent-ostium mismatch are the main predictors for tlf. geographical mismatch means that the stent is implanted either too distal (thereby not fully covering the lesion) or too proximal (thereby protruding too much in the aorta and hampering future engagement with guiding catheters). the investigators hypothesize that, pre-procedural 3d ct coronarography to determine the optimal c-arm angle of the x-ray system with the most accurate visualization of the aorto-ostial angle and determination of localization of calcium, could prevent geographical mismatch.


Eligibility criteria:
inclusion criteria: * clinically indicated non-emergent pci for an aorta-ostial-rca lesion defined as a significant de novo lesion \[by angiography or by physiological assessment\] for which the operator intends to fully cover the ostial rca with stent struts * willing to provide informed consent exclusion criteria: * emergent pci indication: if the ostial rca lesion is the culprit lesion of an acute coronary syndrome \[of note: if the ostial rca lesion is a non-culprit lesion, patient can be included in the trial\] * in-stent restenosis or thrombosis in the ostial rca * renal insufficiency \[egfr\<30 ml/min\] * known allergic reaction to contrast medium

Keywords: right coronary artery computed tomography
nexavar post-marketing surveillance for renal cell carcinoma in japan

Conditions: Carcinoma, Renal Cell

Summary: this study is a regulatory post-marketing surveillance in japan, and it is a local prospective and observational study of patients who have been administered with nexavar for unresectable or advanced renal cell carcinoma (rcc). the objective of this study is to assess safety and effectiveness of nexavar under real-life practice conditions. this study is an all case investigation of which the enrollment period is 15 months, and all patients who received nexavar will be recruited and followed one year since starting nexavar administration.


Eligibility criteria:
inclusion criteria: * patients who received nexavar for unresectable or advanced renal cell carcinoma exclusion criteria: * patients who are contraindicated based on the product label

Keywords: nexavar unresectable or advanced renal cell carcinoma
shock wave therapy: do the external appearance of the device influence clinical outcomes?

Conditions: Plantar Fasciitis; Pain

Summary: to check in patients suffering from chronic plantar fasciitis treated with shock wave therapy, if the outward appearance of the device affects clinical outcomes.

study design: a controlled, randomized, parallel assessor-blinded clinical trial. patients suffering from chronic plantar fasciitis (duration more than 6 months) will be assigned to three different groups: * group i: treatment applied by standard shock waves device. * group ii: shock wave therapy applied by a modified standard device to offer more attractive, more technical, smarter, better appearance, larger and with an expansion of external information devices more sophisticated. * group iii: shock wave therapy applied by a modified standard device to offer a more austere, disfigured, unattractive, modest and smaller external appearance. the shock waves emitted to the 3 devices will be identical; the only difference will be the external image of the device. the main outcome will be the function of the foot by the ffi (foot function index) questionnaire. as secondary variables: pain by vas (visual analogical scale) in different situations, the plantar fascia thickness measured by ultrasound, and the perception of patient recovery measured with the likert scale. adverse effects, painkillers consumption and pain experienced during the treatment of shock waves were also assessed. the patients will be followed and monitored for a month, two months and four months after treatment finished. for the statistical analysis of clinical variables, anova (analysis of variance) will be performed to check whether the evolution of patients over time was different depending on the device applied.

Eligibility criteria:
inclusion criteria: 1. age greater than 18 years. 2. being able to understand the explanations about the potential benefits and risks of study participation. 3. diagnosis of chronic plantar fasciitis. proven by clinical examination: meeting at least 2 of the following criteria: * tenderness in the proximal insertion of the plantar fascia (area of the medial calcaneal tuberosity). * pain during the first steps to get out of bed in the morning and / or after a period of rest time. 4. with a duration of symptoms ≥ 6 months at the time of study entry. 5. having received conservative therapy without success, at least two treatments. treatments may have been made isolated, combined or consecutively. exclusion criteria: 1. bilateral plantar fasciitis. 2. hiper/ hypothyroidism. 3. diabetes mellitus. 4. treatment with anticoagulants 5. inflammatory diseases.

Keywords: shock wave plantar fasciitis placebo effect nocebo effect
iron supplementation to reduce preschoolers anemia: comparison between intermittent and cyclic procedure

Conditions: Anemia

Summary: aim: to evaluate the efficacy of iron supplements given at intervals corresponding to the mean life of red blood cells compared to weekly supplementation, in reducing the prevalence of preschool anemia. method: ninety-nine children from public day care centers with ages from 24 to 59 months old were randomly divided into two groups. all the children received 40 doses of 30 mg of ferrous sulfate during a 10-month intervention period. group 1 received once weekly supplementation and group 2 received supplementation in two 5-month cycles, each cycle consisting of one month of supplementation (20 workdays) and four months without supplementation.

the prevalence of anemia after the supplementation regimens reduced from 20.20% to 5.05% (p \< 0.0005); the reduction was not significantly different between the two groups (p = 0.35). the mean hemoglobin concentration increased in both groups (group 1: 0.27 g/dl; p \< 0.016 and group 2: 0.47 g/dl; p \< 0.0005) without significant differences between the groups (p = 0.17).

Eligibility criteria:
inclusion criteria: * the participants of the study were children with ages ranging from 24 to 59 months old that attended four local public day care centers exclusion criteria: * presence of infection or reported infections within two weeks prior to the intervention * anemia lower than 7.0 g/dl and children taking medications containing ferrous sulfate

Keywords: iron anemia supplementation preschoolers prevalence preschoolers children from public day care centers
implementation of abi and wifi in rural health clinics

Conditions: Peripheral Arterial Disease; Diabetic Foot; Diabetes Mellitus

Summary: the objective of this project is to assess the fidelity and sustainability of in improving provider performance with ankle brachial index (abi) assessment and ulcer staging with the would ischemia foot infection (wifi) tool for new patients with lower extremity ulcers due to peripheral artery disease (pad) and diabetes mellitus (dm) at rhcs in the telemedicine network through a rural provider education program that is aligned with preexisting continuing medical education activities.


Eligibility criteria:
inclusion criteria: to be eligible for the educational program, an rhc must: * already have telemedicine capabilities with the uc davis cht, * be within 3 hours driving time form uc davis medical center, * have a lead practitioner willing to act as the clinic's point person for the proposed educational project, and * have seen at least 10 patients in the prior 3 months with foot ulcers due to dm, pad or combined disease. exclusion criteria: to be eligible for the project, a rhc must not: * have a dedicated foot ulcer assessment program with on-site measurement of arterial perfusion, and * be located within a 45 minute drive of a vascular surgeon
virtual surgical planning systems in mandibular reconstruction

Conditions: Mandibular Neoplasms

Summary: the purpose of this study was to evaluate the accuracy of virtual planning using customized surgical devices (vp3d) in fibula free flap mandibular reconstruction. virtual planning was compared to postoperative scans using cephalometric and three-dimensional (3d) measurements. operative times of both vp3d and conventional surgery groups were compared.


Eligibility criteria:
inclusion criteria: * patients who underwent fibula free flap for mandibular reconstruction * patient ≥18 years old * patient alive 6 months after completion of treatment exclusion criteria: * patient without post-operative scan evaluation * patient with a chirurgical contraindication * pregnant or nursing woman * adult requiring protection (guardianship, supervision)
clinical trial assessing the gnbac1 in patients with onset of type 1 diabetes within 4 years

Conditions: Diabetes Mellitus Type 1

Summary: the monoclonal antibody gnbac1 targets the envelope protein (env) of the human endogenous multiple sclerosis associated retrovirus (msrv), which could play a critical role in different autoimmune disorders, notably type 1 diabetes (t1d). this study is a multicentre study evaluating for the first time the safety and efficacy of gnbac1 in t1d subjects for a first bouble-blind period of 20 weeks followed by an optional open-label period of 24 weeks. the primary objective of the study is to assess the safety and tolerability of six consecutive 4-weekly doses of gnbac1 in subjects with t1d. secondary objectives are to determine the pharmacodynamic response to gnbac1 on biomarkers of t1d.


Eligibility criteria:
main inclusion criteria: * subjects diagnosed with type 1 diabetes in the 4 years prior to signed informed consent; * peak stimulated c-peptide of ≥0.2 nmol/l during a mixed meal tolerance test performed during the screening period; * 18 to 55 years of age (both inclusive); * body weight \>40 to ≤100 kg; * subjects positive for at least one diabetes-associated autoantibody (insulin, glutaminic-acid-decarboxylase-65 \[gad-65\], tyrosine phosphatase-related antigen 2 \[ia-2\], znt8 or islet-cell antibody \[ica\]). main exclusion criteria: * subjects with type 2 diabetes; * pregnant and nursing women.

Keywords: diabetes mellitus, type 1 t1d monoclonal antibody multiple sclerosis associated retrovirus msrv human endogenous retrovirus type w (herv-w) gnbac1 temelimab
role of inflammatory mediators in aerd

Conditions: Asthma, Aspirin-Induced

Summary: the purpose of this research study is to learn new information about the underlying cause of aspirin-exacerbated respiratory disease (aerd) and the benefit of high-dose aspirin therapy. aerd is a disease that involves asthma, recurring nasal polyps, and respiratory reactions to aspirin and other nonsteroidal anti-inflammatory drugs. this study will be conducted on individuals with aerd who are referred to the brigham and women's hospital aerd center for clinical evaluation and potential aspirin desensitization. desensitization to aspirin and subsequent treatment with daily high-dose oral aspirin is standard of care for patients with aerd who do not respond adequately to steroids and have recurrent nasal polyposis or symptomatic asthma. this study will involve five visits to brigham and women's hospital and will align closely with the standard of care for the treatment of aerd.


Eligibility criteria:
inclusion criteria: * history of asthma * history of nasal polyposis * history of at least one clinical reaction to oral aspirin or other nonselective cox inhibitor with features of both lower (cough, chest tightness, wheezing, dyspnea) and upper (rhinorrhea, sneezing, nasal obstruction, conjunctival itching and discharge) airway involvement * stable asthma (post-bronchodilator fev1 of ≥70%, no use of oral or systemic steroids for at least 1 month, and no hospitalizations or emergency room visits for asthma for the prior 6 months) at the time of entry into the study * currently taking montelukast as part of standard asthma treatment for at least 4 weeks before the v1 visit exclusion criteria: * pregnancy or current breastfeeding * history of bleeding diathesis or use of anticoagulant or antiplatelet drugs * history of thrombocytopenia \< 50 x 10\^9/l * hypersensitivity to montelukast * peptic ulcer disease * unstable asthma (post-bronchodilator fev1 of less than 70%, use of oral or systemic steroids for at least 1 month prior to visit 1, or hospitalizations or emergency room visits for asthma for the prior 6 months) * use of zileuton (which can mask symptoms of aspirin-induced reaction) within 1 month prior to the v1 visit * age under 18 or over 75 years * current smoking

Keywords: asthma nasal polyps aspirin sensitivity aerd
exploring the nature, assessment and treatment of stuttering

Conditions: Stuttering; Stuttering, Adult; Stuttering, Childhood; Stuttering, Developmental

Summary: the purposes of this study are to 1) investigate potential speech, language, and psychosocial contributions to the experience of stuttering in monolingual and multilingual speakers, and to 2) evaluate interdisciplinary, telehealth, and speech-language pathology treatment methods and clinical training specific to fluency disorders.

stuttering is a neurophysiological communication disorder characterized by a disruption in the forward flow of speech. stuttering is multifactorial in nature, meaning there are several factors that likely to contribute to the development of stuttering in children and persistence of stuttering into adulthood. about 1% of the worldwide population stutters. in the united states, over 3 million people stutter. research suggests people who stutter present with negative cognitive and affective components of the disorder, and that the general population holds negative perceptions of stuttering. historically, people who stutter spend thousands of dollars on treatment that is not effective in mitigating the negative impact of stuttering on their overall communication and quality of life. speech-language pathologists evaluate and treat persons who stutter across the lifespan. research suggests speech-language pathologists report fluency disorders (stuttering and cluttering) as the communication disorders with which they feel least competent and comfortable. thus, the purposes of this study are to 1) investigate potential speech, language, psychosocial, and motor contributions to stuttered speech production in monolingual and multilingual speakers and to 2) evaluate interdisciplinary, telehealth, and speech-language pathology treatment methods and clinical training tools specific to fluency disorders.

Eligibility criteria:
inclusion criteria: a participant will be considered a child who stutters (ages 2-17 years) if * their parent/caregiver reports concern that their child is a person who stutters, * they exhibit three of more stuttering-like disfluencies (e.g., sound/syllable repetitions, (in)audible sound prolongations, whole-word repetitions) per 300-word speech sample, or * they present with an overall score of 11 or higher on the stuttering severity instrument - 4th edition (ssi-4). a participant will be considered an adult who stutters (18+ years) if * they report they are a person who stutters, * they have received a formal diagnosis of stuttering from a certified speech-language pathologist, * they exhibit three of more stuttering-like disfluencies (e.g., sound/syllable repetitions, (in)audible sound prolongations, whole-word repetitions) per 300-word speech sample, or * they present with an overall score of 11 or higher on the stuttering severity instrument - 4th edition (ssi-4). exclusion criteria: • there are no exclusion criteria for persons who stutter.

Keywords: stuttering, communication competence, adult, treatment
clinical registry of patients under treatment with atypical antipsychotics

Conditions: Schizophrenia; Major Depressive Disorder; Bipolar Depressive Disorder; Parkinson's Disease With Hallucinations

Summary: antipsychotic drugs are characterized by blocking dopaminergic d2 receptors. they have been found to be effective and safe for the treatment of schizophrenia, bipolar disorders, depressive episodes associated with bipolar disorder, or psychotic symptoms in the context of parkinson's disease. atypical antipsychotics have lower blocking potency on d2 receptors, at the time that interact with serotoninergic, adrenergic and histaminergic receptors, among others. quetiapine extended-release has the same clinical efficacy as the immediate-release formulation, but reduces the amount of daily doses, possibly contributing to increased treatment adherence. the purpose of this registry is to explore adherence to treatment, the occurrence of adverse drug reactions and the clinical outcomes in a sample of patients under treatment with atypical antipsychotics in several central american countries. for this study, clinical data will be extracted from the medical records of 1000 patients with schizophrenia, depressive disorders or parkinson's disease with hallucinations. occurrence of adverse drug reactions, namely weight gain, somnolence, extrapyramidal reactions and symptoms of orthostatic hypotension; adherence to treatment; and changes in quality of life and clinical status will be assessed during the first 8 weeks of treatment.


Eligibility criteria:
inclusion criteria: * at least 18 years-old * have a diagnosis of schizophrenia, major depressive disorder, bipolar depressive disorder, parkinson's disease with hallucination * such patients should receive antipsychotics as their usual treatment * they should give informed consent before participating exclusion criteria: * no treatment with atypical antypsichotics * other diseases

Keywords: adverse drug reactions adherence to treatment quality of life clinical status
exercise and radiotherapy, a good combination?

Conditions: Breast Neoplasms

Summary: every year, almost 3000 norwegian women are diagnosed with breast cancer. various symptoms of short-and long-term side effects may be experienced, such as physical deterioration, reduced quality of life and fatigue. at st.olavs hospital, trondheim university hospital, all out-patients undergoing post operative radiotherapy are currently offered participation in group exercise training sessions. the main purpose of this study is to evaluate these out-patient group exercise sessions.


Eligibility criteria:
inclusion criteria: * surgery for breast cancer. * completed chemotherapy treatment. * radiotherapy is scheduled. exclusion criteria: * metastatic disease * pregnancy * drug abuse

Keywords: exercise therapy oxygen consumption
gait in low back pain patients after spinal mobilization

Conditions: Chronic Low Back Pain

Summary: introduction: patients with chronic back pain as a result of degenerated disc disease, besides pain also present with impaired gait. the purpose of this study is to evaluate both the clinical data using clinical rating scales, such as oswestry disability index greek version (odi), numerical pain rating scale for low back pain and leg pain (nprs) and the roland morris disability questionnaire greek version, and kinetic and kinematic characteristics during gait analysis in patients with chronic low back pain as a result of the degenerated disc disease (disc degenerative disease), before and after application of manual therapy techniques. methodology: for the purposes of the study, 75 patients suffering from chronic low back pain were randomly divided into 3 groups of 25 each. each group received five sessions with the first group receiving manual therapy treatment (spinal mobilisation), the second a sham treatment and the third, classic physiotherapy (stretching exercises, tens and massage). to evaluate the effectiveness of each treatment, the visual analog pain scale, two questionnaires (oswestry and roland morris) and also an optoelectronic system for recording and analysis of gait (kinetic and kinematic data) were utilized.

this was a randomized controlled trial comparing the efficacy of spinal mobilization with other physiotherapy interventions (stretching, tens application and swedish type massage) and sham treatment in a group of chronic low back pain patients. the outcome measures included three dimensional gait analysis (kinetic and kinematic data) as well as clinical indicators (numerical pain rating scale, oswestry disability index, roland-moris disability questionnaire).

Eligibility criteria:
inclusion criteria: * low back pain for over 3 months * recent lumbar mri (up to 12 months) * able to walk without the need of walking aids exclusion criteria: * leg length discrepancy of over 2 cm * history of spinal surgery * history of autoimmune disease * history of spondylolysis and spondylolisthesis * spinal fractures * pregnancy * respiratory and/or cardiac disease * history of stroke * hip, knee or ankle osteoarthritis * cauda equina syndrome * spinal inflammation * spinal tumor * steroid drug use in the last month * osteoporosis

Keywords: spinal mobilization manual therapy gait analysis low back pain chronic
effects of strength training in combination with endurance training on exercise tolerance in patients with chronic obstructive pulmonary disease (copd)

Conditions: Chronic Obstructive Pulmonary Disease

Summary: background. exercise intolerance is one of the most devastating consequences of chronic obstructive pulmonary disease (copd). abnormalities in peripheral muscle function such as weakness and reduction in oxidative enzyme activities are commonly found in these patients and may contribute to exercise intolerance.to evaluate whether a systemic weightlifting exercise may improve exercise capacity better than endurance training, or a combined training is more effective, the investigators compared three different training regimens, endurance training alone, systemic weightlifting training alone or a combination of both endurance and weightlifting training. methods.36 patients with stable copd will be evaluated before and after a 4 month training program. each evaluation include a stepwise exercise test on an ergocycle up to the individual maximal capacity during which minute ventilation (ve), oxygen consumption (vo2), carbon dioxide production (vco2), and arterial lactic acid concentration will be measured and the peripheral muscle strength will be determined with the one repetition maximum for eight different muscle groups. percutaneous needle muscle biopsy from the m.vastus lateralis will be performed before and after the training period in order to determine the fiber-type proportions. patients are assigned to one of the following three groups (1) endurance training consisted of 20 min exercise sessions on a calibrated ergocycle two times a week, with a target training intensity at 60% of individual maximum oxygen uptake, (2) systemic weightlifting training two times a week with eight different exercises, each session consist of 15 repetitions of each muscle group, (3) combination of endurance training and systemic weightlifting training. statistical analysis. baseline data for all patients enrolled in the study will be compared by one-way analysis of variance for the three study groups. results before and after training will be analyzed by two- way analysis of variance.


Eligibility criteria:
inclusion criteria: 1. age: 40-75 years 2. mild to moderate copd patients according to the staging schemata of the austrian society of lung and tuberculosis disease (öglut) exclusion criteria: 1. acute infection 2. reduced left ventricular function 3. myocardial infarction 4. stroke 5. severe pulmonary hypertension (mpap\>40mmhg) 6. insufficient treated hypertension rr\>160/95) (participation with sufficient treatment ) 7. severe cardiac arrhythmia 8. malignant diseases 9. severe osteoporosis 10. nicotine abuses 11. other severe chronic diseases

Keywords: improvement of exercise capacity in patients with copd