Kornimate/medical-research-clean huggingface dataset:
research on the clinical effect of shuanghe decoction in treating unstable angina.

Conditions: Unstable Angina

Summary: this study evaluates the clinical efficacy of shuanghe decoction in the treatment of unstable angina. all of the patients will be divided into 2 arms randomly. one of the arms will be treated by conventional western medicine, and the other one will be treated by shuanghe decoction at the base of conventional western medicine.

shuanghe decoction has the function of supplementing qi and activating blood circulation, which will be used to treat patients with qi deficiency and blood stasis syndrome.

Eligibility criteria:
inclusion criteria: * participants diagnosed with coronary heart disease through coronary angiography or coronary cta; patients have at least one of these symptoms: 1. the stability of the nature of angina pectoris changes, that is, frequent attacks of angina pectoris, serious degree and prolonged duration; 2. angina pectoris during rest; 3. the recent occurrence of angina pectoris caused by mild physical activity in the last month. exclusion criteria: * patients diagnosed with stable angina; patients with acute myocardial infarction; chest pain caused by congenital heart disease, valvular heart disease, severe neurosis or arrhythmia; the heart function grade is iii or iv; patients with acute cerebral infarction; patients complicated with other serious primary diseases; patients with acute infection in recent 2 weeks; uncontrolled hypertension (the resting blood pressure \>160/95mmhg within one week); diabetics emerged with serious diabetic complications; patients can't finish the questionnaire due to abnormal mental and nervous or mental disorders; pregnant or lactating women.

Keywords: unstable angina shuanghe decoction
improvement of sarcopenia in patients following two different diets

Conditions: Sarcopenia

Summary: sarcopenia is defined as a decrease in muscular strength and muscle mass, accompanied by a decrease in physical performance. seniors might develop sarcopenia because of a decreased physical activity and a decreased protein intake. many patients also develop sarcopenia after a long stay in an intensive care unit. protein intake is very important when treating sarcopenia. however, meeting the protein requirements at home proves difficult. oral dietary supplements, given in addition to the other known recommendations, might provide a solution. this study will assess the efficacy of the oral dietary supplements for the treatment of sarcopenia.


Eligibility criteria:
inclusion criteria: * patients hospitalized within the chu brugmann, brussels * patients diagnosed with sarcopenia (by means of a dynamometer) * patients having stayed in an intensive care unit for longer than 5 weeks exclusion criteria: * oncology patients * anorexic patients * patients having a life expectancy of less than 6 months * demented patients * bpco patients * patients with neuropathies
robotic-assisted or laparoscopic radical resection for rectal cancer with or without left colic artery preservation

Conditions: Rectal Cancer; Left Colic Artery Stenosis (Diagnosis); Robotic Assisted Laparoscopic Surgery

Summary: brief summary background the preservation of the left colic artery (lca) during rectal cancer resection remains a topic of controversy, and there is a notable absence of robust evidence regarding the outcomes associated with lca preservation. and the advantages of robotic-assisted laparoscopy (ral) surgery in rectal resection remain uncertain. the objective of this study was to assess the influence of lca preservation surgery and ral surgery on intraoperative and postoperative complications of rectal cancer resection. methods participants who underwent laparoscopic (lsc) or ral with or without lca preservation resection for rectal cancer between april 2020 and may 2023 were retrospectively assessed. the patients were categorized into two groups: low ligation (ll) which with preservation of lca and high ligation (hl) which without preservation of lca. a one-to-one propensity score-matched analysis was performed to decrease confounding. the primary outcome was operative findings, operative morbidity, and postoperative genitourinary function.

the investigators retrospectively collected data from the medical records of participants who had rectal cancer at northern jiangsu people's hospital, from april 2020 to may 2023. a total of 612 from 1164 cases were included in this study; in 462 cases, the lca was preserved by ll intraoperatively (ll group), in which 202 cases underwent robotic-assisted laparoscopy (ll-ral subgroup) and 260 cases underwent laparoscopy (ll-lsc subgroup). while in the remaining 150 cases, the lca was not preserved by hl intraoperatively (hl group). in which 70 cases underwent robotic-assisted laparoscopy (hl-ral subgroup) and 80 cases underwent laparoscopy (hl-lsc subgroup).

Eligibility criteria:
inclusion criteria: * low anterior resection for rectal cancer * postoperative pathological diagnosis of rectal adenocarcinoma * informed consent signed prior to surgery. exclusion criteria: * recurrent rectal cancer * emergency surgery * preoperative and intraoperative detection of distant organ metastases or extensive * implantation metastases in the abdominal cavity * palliative surgery * a postoperative pathology report that showed residual cancer cells at the proximal or distal resection margin * no standard chemotherapy for tumor-node-metastasis (tnm) staging ii or iii after surgery * synchronous colorectal carcinoma and other organ tumors * incomplete case data.

Keywords: rectal cancer left colic artery high ligation low ligation inferior mesenteric artery robotic-assisted laparoscopy
assessing the effect of compensatory cognitive intervention among people with severe mental illness

Conditions: Mood Disorders; Schizophrenia; Schizoaffective Disorder

Summary: the aim of this study is to assess the efficacy of a short term compensatory cognitive group intervention - the compensatory cognitive training (cct) among people with severe mental illnesses, receiving ambulatory treatment

this study includes two experimental arms to research cognitive compensatory group treatment in severe mental illness population. the study consists of 4 primary phases: recruitment, assessment, intervention and post-intervention assessment. two arms involve an ambulatory participants. participants are assigned to an intervention or control group according to the order of recruitment. assessment and post-assessment phases include assessments of functional capacity, cognitive functions and severity of symptoms. intervention includes 12 group sessions in a small group of five participants, focusing on learning compensatory strategies aimed to improve attention, concentration, learning, memory, organization, and problem-solving in order to improve everyday functioning. interventions will be performed in addition to standard ambulatory treatment. the control group will receive standard ambulatory treatment only.

Eligibility criteria:
inclusion criteria: * basic knowledge in hebrew * diagnosed according to the icd -10 with severe mental illness: schizophrenia, bipolar disease, schizoaffective disorder or major depression * patients are treated with neuroleptic medication for at least four weeks. exclusion criteria: * acquired neurological disorders including dementia and brain injury. * developmental neurological disorders including developmental intellectual disability and autistic spectrum disorders. * regular electro convulsive therapy treatment with frequency of twice a month or more. * people to whom a guardian has been appointed * current addiction

Keywords: compensatory cognitive treatment mental illness cognitive strategies everyday functioning
management of diabetes in the emergency room: a randomized trial of an insulin protocol.

Conditions: Type 2 Diabetes Mellitus

Summary: this study will examine two questions: 1. whether insulin treatment of high blood sugar in patients with diabetes while they are in the emergency room will improve how quickly they recover from illness if they need to be hospitalized. 2. whether immediately beginning long lasting insulin detemir in patients with diabetes when they are admitted to hospital from the emergency room will improve how quickly they recover from the illness which necessitated hospitalization.


Eligibility criteria:
inclusion criteria: 1. age 18-80 years 2. history of type 2 diabetes mellitus for at least 3 months 3. prior therapy with dietary management, oral agents, or insulin 4. non child-bearing potential or a negative urine pregnancy test 5. initial blood glucose in er \> 200 mg/dl exclusion criteria: 1. subsequent finding of diabetic ketoacidosis or hyperosmolar non-ketotic syndrome after initial evaluation. 2. patients with critical illness suspected to require intensive care unit admission or direct surgical intervention. 3. history of current drug or alcohol abuse. 4. history of current mental illness 5. inability to give informed consent 6. female patients who are pregnant or are breast feeding 7. patients who have clinically significant liver disease with ast/alt (aspartate transaminase/alanine transaminase) \> 3 times the upper range of normal 8. patients currently treated with dialysis
glaucoma screening using dynamic analysis of computerized pupillary light reflex assessment device

Conditions: Primary Open Angle Glaucoma; Primary Open-Angle Glaucoma, Unspecified Eye; Primary Open Angle Glaucoma of Both Eyes; Suspect Glaucoma; Ocular Hypertension

Summary: to explore an effective diagnostic tool of glaucoma through the dynamic analysis of computerized pupillary light reflex assessment device (cplrad) pupillography based on iris recognition techniques and investigate its feasibility in glaucoma screening.

glaucoma is the leading cause of irreversible blindness worldwide, which is characterized by progressive loss of retinal ganglion cells (rgcs) and their optic nerve axons. early diagnosis and treatment can effectively prevent the progression of the disease and avoid blindness. the damage of rgcs appears in the early stage of glaucoma, and the asymmetry of the eyes has also been observed clinically. cplrad may serve as an effective screening tool for glaucomatous optic neuropathy, since they can dynamically detect abnormal pupillary responses from a novel sequence of light stimuli and functionally-shaped stimuli. the current theoretical evidence of relative afferent pupillary defect/pupillary light reflex (rapd/plr) as a functional test for predicting nerve damage is insufficient, and pupil detection technology is not yet mature. therefore, the investigators want to complete these tasks: 1) collect the clinical examination data and objectively measure the pupil dynamic parameters monocularly and/or binocularly as indicators from the retina and optic nerve in glaucoma patients 2) design rapd/plr detection technology and develop dynamic analysis system; 3) verify the feasibility of rapd/plr applied to early glaucoma screening through clinical trials. the pupil image dynamic analysis and iris recognition system will provide a simple, inexpensive and non-invasive screen tool, and is highly reliable and cost-effective.

Eligibility criteria:
inclusion criteria: * with open angles on gonioscopy * best-corrected visual acuity ≥0.5 * spherical refraction within ±6.0 diopters (d), and cylinder correction within 3.0 d exclusion criteria: * eyes with any evidence of physical abnormality of the iris or pupils on slit-lamp examination * eyes with a history of trauma or inflammation * undergone an intraocular surgery or laser within the previous 6 months /except uncomplicated cataract surgery * using systemic or topical medications that could affect pupil responses, including pilocarpine or atropine * presence of any media opacities that prevented good quality optical coherence tomography (oct) or fundus images * presence of any retinal or neurological disease other than glaucoma abnormal ocular motility that prevents binocular fixation (eg, nystagmus, strabismus) * with severe system diseases or psychiatric disorders
hyperbaric oxygen therapy can improve neurological state post meningioma removal surgery

Conditions: Intracranial Meningioma; Neurologic Deficits

Summary: the aim of the current study is to evaluate, in a prospective cross-over, randomized study, the effect of hyperbaric oxygen therapy (hbot) on patients with chronic neurological deficits and cognitive impairment after anterior skull base meningioma tumor removal.


Eligibility criteria:
inclusion criteria: * post intracranial meningioma removal surgery 3-12 months prior to the inclusion in the study. * all patients have to have persistent cognitive or neurological complaints regarding without noticeable improvement during the last month prior to their enrolment. * age 18 years or older. exclusion criteria: * dynamic neurologic/cognitive improvement or worsening during the past month; * evidence of dynamic cognitive/neurological improvement in the last month. * previous brain radiotherapy and/or radiosurgery. * steroids dependence * seizures 1 month previous to inclusion * had been treated with hbot for any other reason 1 month prior to inclusion; * have any other indication for hbot; * chest pathology incompatible with pressure changes; * inner ear disease; * patients suffering from claustrophobia; * inability to sign written informed consent; * smoking patients will not be allowed to smoke during the study and if they would not comply with this demand they will be excluded.
the effects of a jump rope exercise program on vascular health, inflammatory markers in prehypertensive adolescent girls

Conditions: Prehypertension; Blood Pressure; Abdominal Obesity; Adiposity

Summary: the purpose of this study was to examine the impact of a 12-week jump rope exercise program on blood pressure, arterial stiffness, vasodilating and vasoconstricting factors, inflammatory markers, and body composition in prehypertensive adolescent girls. forty prehypertensive adolescent girls participated in this study. the girls were randomly divided into the jump rope exercise intervention group (ex, n=20) and control group (con, n=20). the ex group performed a jump rope training program at 40-70% of their heart rate reserve (hrr) 5 days/week for 12 weeks (sessions 50 minutes in duration). the con group did not participate in any structured or unstructured exercise protocol. blood pressure, arterial stiffness, plasma nitrate/nitrite levels, endothelin-1, c-reactive protein, and body composition were measured before and after the 12-weeks study.


Eligibility criteria:
inclusion criteria: * prehypertensive * sedentary (no regular exercise training or physical activity within the last year) * no weight loss diet during the last six months exclusion criteria: * pregnancy * chronic disease * daily medication use (including antioxidants and weight loss supplements)

Keywords: arterial stiffness endothelin-1 c-reactive protein adiposity exercise jump rope
intravenous sub-dissociative dose ketamine injection versus infusion for analgesia in the emergency department

Conditions: Pain

Summary: objective: the purpose of this study is to determine if administering ketamine as an intravenous (iv) infusion over 15 minutes, as compared to an iv push, will decrease adverse drug reactions without attenuating its analgesic effects. study design: prospective, randomized, controlled, double-blind trial.

objective: the purpose of this randomized, controlled, double-blind trial is to evaluate if sub-dissociated dose ketamine given as an infusion versus an intravenous (iv) push over 1 minute has fewer and/or less severe adverse drug reactions and provides equivalent analgesia for patients with moderate to severe pain in the emergency department (ed). study design: prospective, randomized, controlled, double-blind trial participants: research assistants will recruit patients ≥18 years old with moderate to severe pain (nrs≥5) and an anticipated stay in the emergency department ≥1 hour. a sample size calculation was performed based on prior data which suggests that 60% of iv push arm and 20 % of infusion arm will have adverse drug reactions. investigators assume an alpha of 0.05 and a power of 0.8, which results in 56 patients needing to be enrolled. intervention: after a trained research assistant obtains written informed consent, pharmacists will randomize the participants to the iv push or iv infusion arm of the study. all patients will be placed on a cardiac monitor. all patients will receive and iv push over 1 minute and a 100 ml normal saline minibag over 15 minutes. in the iv push arm, pharmacists will provide to the nurse ketamine 0.3 mg/kg in a 10 ml syringe and a 100 ml normal saline minibag. the nurse will start the minibag of normal saline and then administer the iv push of ketamine over 1 minute. in the iv infusion arm, pharmacists will provide to the nurse ketamine 0.3 mg/kg in a 100 ml normal saline minibag and a 10 ml syringe of normal saline. the nurse will start the minibag of normal saline and then administer the iv push over 1 minute. data collection: the trained research assistant will collect data on the patients' pain scores, adverse drug reactions (presence, severity, and how bothersome they are), and vital signs. statistical analysis: investigators will perform descriptive statistics, compare the proportion of patients with side effects, compare the severity of the side effects scores, and compare how bothersome the side effects.

Eligibility criteria:
inclusion criteria: * pain nrs ≥5 * anticipated stay in ed ≥1 hour exclusion criteria: * pregnant or breast feeding * vital sign abnormalities (sbp \ 180, hr \ 150, rr \ 30, weight \ 115 kg) * arrhythmias * altered mental status (active psychosis/delirium) * administration of opioid pain medication in previous 1 hour * history of acute head or ocular trauma * presence of known intracranial mass or vascular lesion

Keywords: ketamine emergency department
clinical evaluation of a manufacturing process for a frequent replacement silicone hydrogel multifocal contact lens

Conditions: Refractive Ametropia

Summary: the purpose of this clinical trial was to evaluate the clinical performance of a manufacturing process on a frequent replacement multifocal contact lens.

subjects will be expected to attend 3 scheduled visits. eligible subjects will wear each study lens type in a cross-over fashion for approximately 2 days.

Eligibility criteria:
key inclusion criteria: * able to understand and sign an consent form (icf) that has been approved by an institutional review board (irb); * willing to stop wearing habitual contact lenses for the duration of study participation; * currently wearing multifocal soft contact lenses in both eyes for a minimum of 5 days per week and 8 hours per day during the past 3 months; * other protocol-defined inclusion criteria may apply. key exclusion criteria: * any eye infection, inflammation, or abnormality or disease (including systemic) that contraindicates contact lens wear, as determined by the investigator; * any use of systemic or ocular medications for which contact lens wear could be contraindicated, as determined by the investigator; * history of refractive surgery, or plan to have refractive surgery during the study; * current or history of dry eye in either eye that would preclude contact lens wear, in the opinion of the investigator; * monovision contact lens wear; * other protocol-defined exclusion criteria may apply.

Keywords: presbyopia
ketotifen ophthalmic solution with emedastine in patients with seasonal allergic conjunctivitis

Conditions: Seasonal Allergic Conjunctivitis

Summary: medications available for the treatment of seasonal allergic conjunctivitis include antihistamines. these medicines block the release of histamine, a substance in the body that is released when an allergic reaction occurs. novartis (nvs) has developed an eye drop formulation of a well tried antihistamine called ketotifen. this study will compare the efficacy and the tolerability of ketotifen eye drops with emedastine, which is a popular treatment for seasonal allergic conjunctivitis in china.


Eligibility criteria:
inclusion criteria: * age 3 years or older. * history of seasonal allergic conjunctivitis * presence of bilateral ocular itching/conjunctival hyperaemia (redness) at baseline: 1. at least intensity degree 2 for itching, and 2. at least intensity degree 4 for composite score of itching and conjunctival hyperaemia exclusion criteria: other systemic/ophthalmic conditions * presence of any form of allergic conjunctivitis other than seasonal allergic conjunctivitis (e.g. perennial allergic conjunctivitis, vernal keratoconjunctivitis, atopic keratoconjunctivitis, giant papillary conjunctivitis). * active bacterial or viral conjunctivitis or history of ocular herpes. * presence or history of severe dry eye. previous treatments * any systemic or ocular corticosteroids within two (2) weeks prior to randomization. * any systemic or ocular mast cell stabilizers within two (2) weeks prior to randomization. * any other ophthalmic medication within three (3) days prior to randomization. other protocol-defined inclusion/exclusion criteria may apply

Keywords: allergic conjunctivitis ketotifen histamine
microvascular reactivity of the gingiva around implant born crown

Conditions: Dental Implants

Summary: apply lsci method for follow-up changes in regional blood flow after compression of the gingiva in order to compare the vascular reactivity of the attached gingiva at implant versus at tooth.

this study will examine the effects of implantation and peri-implant soft tissue shaping on the circulation and the regeneration processes of the human gingiva. the primary aim is to determine the effect of a short term disruption of the blood flow in the gingiva next to an implant and the contralateral tooth, in order to compare the functionally active collateral circulation in the attached gingiva at these respective regions. using laser speckle contrast imaging technique (lsci), which provides blood perfusion data, the investigators will have the possibility to detect functional alterations in gingival microcirculation during and after a short term compression of the gingiva. the secondary aim is to assess and compare the time course of the restoration of the circulation on the affected areas. further aims are to observe if the compensation capability of the circulation is influenced by gingival thickness (biotype) and patient's gender.

Eligibility criteria:
inclusion criteria: patient with single dental implant installed in the front region of the jaw at least 6 months ago. on the contralateral side a natural tooth is located. exclusion criteria: * systemic disease * smoking * alcohol abuse * pregnancy * gingivitis * periodontitis

Keywords: periimplant soft tissue gingiva human microcirculation
long term effects of gestational diabetes mellitus in a population of parous women

Conditions: Gestational Diabetes Mellitus

Summary: the primary goal of this proposed research deals with estimating the risk of developing type 2 diabetes and metabolic syndrome in women with a history of gdm compared to women without a history of gdm. in addition, this study will attempt to evaluate the effect of parity on the late appearance of type 2 diabetes and metabolic syndrome in this unique population.


Eligibility criteria:
inclusion criteria: * the study group will include women who gave birth in shaare zedek medical center between the years 2000 and 2010. * women with a gdm history will be identified based on the gestational diabetes clinic files. * women without a history of gdm who will be the control group will be identified from the shaare zedek medical center birth registration records exclusion criteria: * we established the following exclusion criteria: * women who are diagnosed with metabolic syndrome before pregnancy or have type 1 or type 2 diabetes, and * women with severe chronic diseases.

Keywords: long term effects of gestational diabetes mellitus in a population of parous women gestational diabetes mellitus- gdm is defined as glucose intolerance diagnosed during pregnancy and not present shortly after birth