Kornimate/medical-research-clean huggingface dataset:
clinical evaluation of new treatment strategy of mucous membrane pemphigoid using large dose of prednisolone plus intra-lesional of triamcinolone acetonide followed by combination of mycophenolate mofetil, dapsone and low dose prednisolone

Conditions: Benign Mucous Membrane Pemphigoid

Summary: abstract: mucous membrane pemphigoid (mmp) is an autoimmune blistering disorder characterized by inflammation, blistering, and scarring and predominantly occurring at mucous membranes. successful treatment can be challenging, and uncontrolled disease may result in significant morbidity with scarring of the conjunctiva and oropharynx leading to blindness and dysphagia. therefore successful treatment is a must to improve patient quality of life. aim of work: to evaluate clinically the effectiveness of systemic large dose of prednisolone plus intra-lesional of triamcinolone acetonide followed the systemic combination of mycophenolate mofetil (mmf), dapsone and low dose prednisolone in treatment of mmp cases. materials and method: 10 patients suffering from mmp were selected after complete diagnosis based on their clinical diagnosis and immunopathologic findings of igg, iga, and/or c3 targeting skin basement membranes with a linear deposition pattern refered from dermatology department. these patient were treated using large dose of prednisone 60mg daily plus intrational injection of triamcinolone acetonide every week until no further improvement of the lesion occurred (stage i) then the prednisolone is withdrawn gradually and substituted with using 1 g of mmf plus 50 mg dapsone till the lowest dose of prednisone could be reached (stage ii). the lesion size and pain score will be assessed before treatment and during treatment in stage i and stage ii. these data will be tabulated and statistically analyzed

before starting any treatment the size of the lesion will be measured and pain score will be evaluated. then patient were treated using large dose of prednisone 60mg daily plus intra-lesional injection of triamcinolone acetonide every week until no further improvement of the lesion occurred (stage i) at this stage the patients pain would be evaluated and lesion size would be measured . as no further improvement is gained, the prednisolone is withdrawn gradually and substituted with using 1 g of mmf plus 50 mg dapsone till the lowest dose of prednisone could be reached (stage ii) at this stage the patients pain would be evaluated and lesion size would be measured. then the data will be tabulated and statistically analyzed regarding pain score and lesion size

Eligibility criteria:
inclusion criteria: patients with age references patients confirmed from dermatology department that they had mucous membrane(mmp) pemphigoid- patients are not allergic o to the drugs being used for the treatment exclusion criteria: patients below or above age reference used in the study patients with other oral lesions not being confirmed as mmp patients with systemic diseases preventing using of the drugs -
register of autoimmune bullous dermatoses

Conditions: Autoimmune Bullous Dermatoses

Summary: autoimmune bullous dermatoses are a group of diseases with chronic course. they are provoked by the production of autoantibodies against the dermal-epidermal junction or against the inter-keratinocyte junctions, resulting in the formation of intra-epidermal or sub-epidermal blisters. the diagnosis of autoimmune bullous dermatoses is based on clinical and immunopathological findings, including skin direct immunofluorescence. systemic corticosteroid therapy is generally considered as the mainstay of treatment for many years both for bullous pemphigoid and pemphigus which are the most frequent diseases.

the aim of the study is the creation of a register of patients suffering from autoimmune bullous dermatoses to quickly identify patients who can be included in clinical trials or retrospective epidemiological studies

Eligibility criteria:
inclusion criteria: * patients with autoimmune bullous dermatosis * patients cared for in dermatology referral center of reims, rouen or limoges * patient consenting to participate to the study exclusion criteria: - patient \<18 years
clinical evaluation of a dental glass ceramic

Conditions: Caries; Dental Trauma

Summary: a clinical trial with an experimental glass ceramic (shades a1, a2 and a3) to ensure the safety and efficacy of the product. it is a study with single-arm in which inlays and onlays for molars and premolars are adhesively luted.


Eligibility criteria:
inclusion criteria: * age: 18-65 years * indication for indirect restorations (inlay, onlay) in molar or premolar - replacement of insufficient fillings (e.g. due to caries at margins, filling fracture, fracture of the tooth, poor quality of the surface, leaking margin, etc.) or extensive primary caries * the occlusal area of the restoration must cover at least 1/3 of the occlusal area of the tooth. * participant wishes a restoration within the scope of the study (signed informed consent after detailed explanation and study of the patient information) * pre-operative discomfort of the tooth to be restored should not exceed 3 on the visual analogue scale (vas) (0=no pain, 10=maximum conceivable pain) due to temperature stimulus or bite sensitivity * max. 2 restorations per participant in different quadrants. * healthy periodontium, no active periodontitis * contact with adjacent teeth (at least at one side) and opposing teeth present with at least one contact point. * sufficient language skills exclusion criteria: * sufficient isolation not possible, dry working field cannot be guaranteed * participants with a proven allergy to one of the ingredients of the materials used * participants with proven allergy to local anaesthetics * high caries activity/ poor oral hygiene * participants with severe systemic diseases * pregnancy * symptoms of sars (severe acute respiratory syndrome)-cov2 (corona virus 2) infection
preoperative intravenous omega 3 fatty acids administration in elderly patients undergoing hip surgery

Conditions: Hip Surgery

Summary: the perioperative administration of n-3 fatty acids has been shown to lead to favorable effects on outcome in patients with severe surgical interventions by lowering the magnitude of inflammatory response and by modulating the immune response. no study with preoperative administration of iv omega 3 fatty acids as a part of total parenteral nutrition (tpn) or monotherapy with it to demonstrate its effects on inflammatory and immune response has been conducted. so, this study has been planned to judge the inflammatory response of preoperative monotherapy with iv omega 3 fatty acids in elderly patients undergoing hip surgery considering the hyper-inflammation associated with this type of surgery in elderly patients.


Eligibility criteria:
inclusion criteria: 1. elderly male or female patients undergoing hip surgeries 2. age \> 60 years 3. the patients who give written informed consent exclusion criteria: 1. refusal to participate in the study 2. allergy to any of the constituents of nutritional products 3. hiv positive patients, patients with primary diagnosis of hypertriglyceridemia, patients on long term steroid therapy and cyclooxygenase inhibitors (more than 3 months) 4. severe cardiac disease, hepatic disorders (total bilirubin \> 1.5 times the upper limit of normal), psychiatric disorders likely to affect compliance, severe hemorrhagic disorders, stroke, embolism 5. uncontrolled severe renal failure (serum creatinine \> 2 mg/dl) without dialysis/hemofiltration 6. participation in any other clinical trial within the last 2 months

Keywords: omega 3 fatty acids inflammation hip surgery inflammatory status infectious complications
impact of maternal mental health on the oral health status and oral health-related quality of life of their children

Conditions: Mental Health Disorder; Oral Health-Related Quality of Life

Summary: dental caries is a complex multifactorial disease that is strongly related to and influenced by the children's dietary habits, sugar intake, salivary flow, salivary fluoride level, and preventive behaviors. based on the literature, other factors can affect child dental caries including the influence of social factors, such as the family environment. to avoid suffering from dental caries, preventive oral hygiene practices beginning in childhood are crucial. however, parents are the primary providers of oral health care for their children and they generally play a pivotal role in the overall health and oral health of both children and adolescents. therefore, this study aims to investigate the impact of maternal mental health in the form of depression, anxiety, or stress and their perceived social support on the oral health status and ohrqol of their children.


Eligibility criteria:
inclusion criteria: * egyptian mothers. * preschool children of both sexes aged (3-5 years who have a full set of primary dentition). * healthy children with no long-term medications, and with no physical, learning, or mental disabilities. exclusion criteria: * mothers who do not consent to participate in the study (either for themselves or for their children) * mothers with any diagnosed mental disorders. * pregnant mothers or mothers who delivered within the last year. * mothers with any diagnosed physical disabilities.

Keywords: mental health social support oral health-related quality of life
prevention of dysbiosis complications with autologous fmt in aml patients

Conditions: Leukemia, Myeloid, Acute

Summary: the investigators propose to use autologous fecal microbiota transplantation (afmt) to acute myeloid leukemia (aml) patients treated with intensive chemotherapy and antibiotics in order to restore the balance of their intestinal microbiome and thereby eradicate treatment-induced multidrug resistant bacteria (mdrb), infection-related complications, as well as sequelae to the gastrointestinal tract. therefore, the investigators propose to perform a single-arm multicentre prospective fecal microbiota transplantation (fmt) trial in aml patients receiving intensive chemotherapy, and who are usually heavily treated with broad-spectrum antibiotics during aplasia that generate a profound status of dysbiosis. for this purpose, at the time of admission and aml diagnosis, patients will be requested to donate stools that will be comprehensively screened, and if deemed appropriate according to protocol criteria, conditioned and stored frozen until future processing and transplantation after aplasia completion.


Eligibility criteria:
inclusion criteria: * patients ≥ 18 and ≤ 75 years old with de novo diagnosis of aml or high-risk myelodysplastic syndrom for whom intensive induction chemotherapy is anticipated within 10 days after admission * patients willing to donate stool samples and to follow protocol recommendations * signature of informed and written consent exclusion criteria: * acute promyelocytic leukemia (aml-m3) * known allergy or intolerance to trehalose or maltodextrin * pregnancy: positive urinary or blood test in female of childbearing potential * severe disease with a life expectancy \< 3 months * other ongoing interventional protocol that might interfere with the study * non eligibility for collection of autologous stools upon admission: * patients refusing to consent * antibiotherapy at the time of study inclusion ≥ 4 days * concomitant or previous diagnosis of a significant inflammatory bowel disease (uc, cd) or other progressive digestive disease requesting treatment or further medical exploration * presence of severe colitis of any etiology at the time of admission or severe digestive disorders (acute or chronic diarrhea) within 3 months preceding inclusion * patient getting a recent colonoscopy (within 3 months preceding inclusion) * detection of mdrb, pathogenic bacteria, parasites, norovirus and/or rotavirus during screening of autologous stool collected at baseline * non eligibility for inoculum transplantation: persistent mucositis, colitis, or haemorrhoids, presence of blood in more than 50% of patient's faeces the week preceding the transplantation * non feasibility of inoculum procedure: patient refusal; technical or biological mismatch of the inoculum * absence of effective contraceptive method for female of childbearing potential * lactation * inability to give an informed consent

Keywords: autologous fecal microbiota transplantation
tackling depression and anxiety: a working memory intervention

Conditions: Major Depression; Anxiety Disorder

Summary: anxiety and depression are both associated with impairments in executive functions, including working memory (wm) which is needed to maintain and manipulate goal-relevant information. due to these wm impairments anxious and depressed individuals have difficulties inhibiting and shifting from irrelevant (negative) information and updating goal relevant information. this study explored whether training wm decreases these impairments and reduces clinical symptoms and rumination. eighty-four individuals diagnosed with major depression and forty-nine individuals with an anxiety diagnosis executed wm or control tasks three times a week, during four weeks. before, after training and at a two months follow-up measurement depression and anxiety symptoms, wm capacity and rumination behaviour were assessed. training wm did only result in a reduction of anxiety symptoms in the depression group. these findings are inconsistent with promising results of individual studies showing training wm result in an enlarged wm capacity and a decrease of psychopathological symptoms. however, our results are in line with recent meta-analyses and reviews which show that wm training do not lead to generalized effects and therefore, doubt the clinical relevance of wm training programs.


Eligibility criteria:
inclusion criteria: * major depression diagnosis * anxiety disorder diagnosis exclusion criteria: * current psychosis * current substance dependency

Keywords: depression anxiety working memory rumination cognitive training executive functioning
effects of dexmedetomidine premedication on emergence agitation after strabismus surgery in children

Conditions: Inhalational Anesthetics Adverse Reaction; Delirium on Emergence; Strabismus Following Ocular Surgery

Summary: sevoflurane is frequently used for pediatric anesthesia because it has low pungency and rapid onset and offset of action.the reported incidence of emergence agitation (ea) following sevoflurane anesthesia varies from 10-80%. despite its spontaneous resolution, ea is still considered as a potentially serious complication because of the risks of self-injury, and because of the stress caused to both caregivers and families. dexmedetomidine, an alpha2-adrenoceptor agonist with sedative, analgesic, and anxiolytic actions, has been used in pediatric populations.several prospective clinical trials in children have shown that dexmedetomidine significantly reduces the incidence of ea prior to recovery from sevoflurane anesthesia. however, the effect of dexmedetomidine premedication on emergence agitation has not been fully evaluated. the purpose of the present study was to verify the hypothesis that intranasal premedication with dexmedetomidine is effective in reducing emergence agitation after sevoflurane anaesthesia.

emergence agitation was assessed using the pediatric anesthesia emergence delirium (paed) scale.the paed scale contains five items (eye contact, purposefulness of actions,awareness of surroundings, restlessness and consolability), each scored on a 0 to 4 scale, for a maximum of 20 points. a perfectly calm child scores 0 and extreme agitation corresponds to 20 points. the peak ea score was recorded. agitation scores \ = 10 were regarded as presence of agitation.

Eligibility criteria:
inclusion criteria: * aged2-6 yr, with american society of anesthesiologists physical status i or ii, scheduled to undergo strabismus surgery during general anesthesia exclusion criteria: * mental disease, neurologic disease, treatment with sedatives, full stomach, or indication for rapid sequence induction.
a study in patients with venous leg ulcers and measuring the effects of using geko™ device

Conditions: Venous Leg Ulcer

Summary: this is a single centre open label study measuring lower limb physiology in patients with venous leg ulcers at the university hospital of south manchester. ambulatory venous pressure, venous transit times, wound bed tissue oxygenation and changes in microcirculation will be measured at baseline after the gekotm device is activated. ambulatory venous pressure and venous transit times will be performed whilst the participant is standing, sitting and supine


Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years 2. intact healthy skin at the site of device application 3. able to understand the patient information sheet 4. willing and able to give informed consent 5. willing and able to follow the requirements of the protocol 6. subjects who had a chronic venous leg ulcer (i.e. ceap classification of c6 1) greater than 1 cm2 and less than 10 cm in maximum diameter, 7. abpi of ≥0.8 8. patient treated with 4 layer compression bandaging exclusion criteria: 1. wound infection either acute or chronic 2. history of significant haematological disorders or dvt with the preceding six months 3. pregnant 4. pacemakers or implantable defibrillators 5. use of any other neuro-modulation device 6. current use of tens in pelvic region, back or legs 7. use of investigational drug or device within the past 4 weeks that may interfere with this study 8. recent surgery that may affect the study (such as abdominopelvic, or lower limb) in the opinion of the investigator. 9. recent trauma to the lower limbs 10. size of leg incompatible with the geko™ device. 11. obesity (bmi \> 34) 12. any medication deemed to be significant by the investigator 13. subjects who had an index venous leg ulcer greater in maximum diameter than 10cm in any one dimension, or less than 2cm. 14. diabetes 15. clinical evidence of peripheral arterial disease (i.e signs or symptoms, in the opinion of the researcher)
a sleep intervention to improve outcomes among women at high risk of breast cancer

Conditions: Breast Cancer; Sleep

Summary: participants are asked to participate in a research study of the effect of a sleep intervention on improving sleep habits and reducing their risk of breast cancer. participants are asked to participate in this research study because they have been identified as being at higher than average risk of developing breast cancer. the purpose of this study is to compare women who get a sleep intervention to women who do not get a sleep intervention. this study team will compare these two groups of women to see if the sleep intervention improves their sleep and if it lowers markers of inflammation that have been associated with an increased risk of breast cancer.

objective 1: to test the effectiveness of the go! to sleep program at improving the sleep duration and sleep quality in women at high risk of breast cancer. objective 2: to test the effectiveness of improvements in sleep quality and/or duration due to the go! to sleep program on biomarkers of inflammation in women at high risk of breast cancer. objective 3: to evaluate the effectiveness of improvements in health-related quality of life after the go! to sleep in women at high risk of breast cancer.

Eligibility criteria:
inclusion criteria: 1. women at high risk of breast cancer due to one or more of the following: * carry deleterious mutations in the brca1, brca2, pten, tp53, stk11, or cdh1 genes * previous diagnosis of lobular carcinoma in situ (lcis), atypical ductal hyperplasia (adh) or atypical lobular hyperplasia (alh) * lifetime risk of 20% or greater as calculated by the national cancer institute (nci) breast cancer risk assessment tool or the tyrer-cuzick ibis risk assessment tool 2. ability to access the internet and watch videos online. 3. valid email address. 4. self-reported sleep duration of 6 hours per night or less exclusion criteria: 1. previous diagnosis of cancer. 2. lack of ability to read and converse in english. 3. lack of ability to give informed consent.

Keywords: breast cancer go! to sleep sleep
work productivity in hyperventilation syndrome

Conditions: Hyperventilation Syndrome

Summary: hyperventilation syndrome is associated with impaired quality of life. the aim of the study is to assess the relationship between work productivity, including absenteeism and presenteeism, and the severity of hyperventilation syndrome


Eligibility criteria:
inclusion criteria: * holders of employment contracts for at least 8 days * diagnosis of hyperventilation syndrome confirmed by: compatible symptoms and at least two symptoms reproduced by the hyperventilation challenge test: nijmegen's score\> 23 ; demonstration of alveolar hyperventilation ( either on rest blood and / or at rest (paco2 at rest \<36 mmhg and d (a-a) o2 normal; either during the hv test (increased recovery time of the basic petco2 after voluntary hyperventilation (greater than 5 minutes) exclusion criteria: * existence of another chronic pulmonary disease (asthma, bronchial dilation, copd, diffuse interstitial pneumonia, neuromuscular pathology ...) or cardiac (rhythm disorder, ischemic heart disease ...) which can participate in dyspnea * psychiatric illness / psychotropic treatment * pregnancy * patient already included in a clinical research protocol involving new therapeutics may not be included in this protocol * specific physiotherapy or previous training

Keywords: hyperventilation syndrome work productivity absenteeism presenteeism
airway management during unusual tracheal stenosis

Conditions: Tracheal Stenosis

Summary: tracheal stenosis is a serious complication following prolonged intubation. there are important differences in the challenges of airway management. this study consists of our anesthesia management experience in patients with unusual placement of tracheal stenosis due to covid-19 undergoing tracheal dilatation.

tracheal stenosis is a serious complication following prolonged intubation. two types of tracheal stenosis; glottic and subglottic stenoses have common features in that they are challenging in terms of ventilation, oxygenation and intubation. however, there are important differences in the challenges of airway managementa thinner tube may be sufficient to overcome the airway difficulty in glottic stenoses. however, in subglottic tracheal stenosis, a thinner tube may not be conveyed to the distal of the stenosis. as a result, adequate ventilation and oxygenation may not be provided with an intubation tube placed proximal to the trachea. this study consists of our anesthesia management experience in patients with unusual placement of tracheal stenosis due to covid-19 undergoing tracheal dilatation.

Eligibility criteria:
inclusion criteria: * asa 1-2-3 patients over the age of 18 who are scheduled for an elective laryngeal procedure due to subglottic stenosis will be included in our study. exclusion criteria: 1. patients who did not agree to participate in the study. 2. congestive heart failure (ejection fraction ≤ 35 %) 3. emergency laryngeal procedures. 4. patients under 18 years old. 5. patients with asa \> 3.

Keywords: prolonged intubation, tracheal stenosis covid-19