Kornimate/medical-research-clean huggingface dataset:
managing non-acute low back symptoms in occupational health: two trials

Conditions: Low Back Pain, Recurrent; Low Back Pain

Summary: the purpose of this study is: * epidemiological part: characteristics of low back pain patients from a forestry company in finland. data is collected from occupational health databases and self administered questionnaires. * intervention: to determine the effectiveness and cost-effectiveness of several different interventions in subacute low back pain (lbp) patients in occupational health (oh).

eligible subjects were divided into two randomised controlled trials with the name of "mild" or "moderate" low back pain trials (interventions) and also mild vs natural course (nc) and moderate vs. nc interventions. pain, disability and quality of life were collected up to 2 years by self-administered questionnaires and sickness absences were gathered from electronical records for at least 4 year's follow up time.

Eligibility criteria:
inclusion criteria: * age 18-56 years * present employment at the company * at least one criteria out the following qualified for the study: * nonspecific lbp with the duration of 2 weeks or more * radiating, present low back pain * recurrent lbp (2 or more episodes per year) * work absence because of lbp * included subjects also responded having low back pain during preceding week prior to the questionnaire (vas ≥ 10 mm, visual analogue scale 0-100 mm) according to pain level, patients were later divided into two separate rct's, "mild": vas 10mm - 34mm, "moderate": vas 35mm or more. exclusion criteria: * retirement * acute nerve root compression symptoms * malignant tumor * recent fracture * severe osteoporosis * other specific disease preventing participation in the follow-up

Keywords: low back pain recurrent subacute secondary prevention primary care occupational health back book rehabilitation
autologous muscle derived cells female stress urinary incontinence clinical study

Conditions: Urinary Incontinence, Stress

Summary: this is a clinical trial to study the safety and effectiveness of autologous muscle derived cells for urinary sphincter repair (amdc-usr) for the treatment of female stress urinary incontinence (sui).

study comparing intrasphincteric injection of amdc-usr with placebo. subjects unblinded after 12 months visits, but followed for 2 years. subjects randomized to placebo could elect to receive open-label amdc-usr after completing 12 months visit.

Eligibility criteria:
inclusion criteria: * female patient has primary symptoms of sui, as confirmed by patient medical history and clinical symptoms, including a focused incontinence evaluation. exclusion criteria: * patient has symptoms of pure urge incontinence as confirmed by basic evaluation of etiology from a patient medical history, including a focused incontinence history. * patient has symptoms of mixed urinary incontinence where urge incontinence is the predominant factor. * patient has had stress urinary incontinence symptoms less than 6 months prior to signing the informed consent. * patient has not previously attempted conservative treatment for at least 1 month prior to signing the informed consent. (examples of conservative treatment include behavior modifications, bladder exercises, biofeedback, etc.) * patient has more than 2 episode of awakening to void during normal sleeping hours. * patient cannot be maintained on a stable dose and/or frequency of medication (including diuretics) known to affect lower urinary tract function, including but not limited to, anticholinergics, tricyclic antidepressants or alpha-adrenergic blockers, for at least 2 weeks prior to randomization or is likely to change during the course of the study. * patient is pregnant, lactating, or plans to become pregnant during the course of the study. * patient refuses to provide written informed consent. * patient is not at least 18 years of age. * patient is not available for the follow-up evaluations as required by the protocol.

Keywords: urinary incontinence, stress tissue therapy (cell therapy) transplantation, autologous
retrobulbar methylprednisolone as adjunctive treatment in optic neuritis trial

Conditions: Optic Neuritis; Treatment; Methylprednisolone

Summary: a double-blind prospective randomized clinical trial of treatment for optic neuritis comparing visual outcome of patients treated by standard therapy (intravenous methylprednisolone) + placebo injection and standard therapy + retrobulbar methylprednisolone.

a double-blind prospective randomized clinical trial of treatment for optic neuritis comparing visual outcome of patients treated by standard therapy (intravenous methylprednisolone) + placebo injection and standard therapy + retrobulbar methylprednisolone. enrollment: 50. randomized groups (2) 1. standard treatment + placebo 2. standard treatment + intervention masking: double (participant and outcomes assessor) participants won't be aware to which group they were assigned. investigator in charge of assessing outcomes and analyzing data won't be aware to which group participants were assigned

Eligibility criteria:
inclusion criteria: * both genres * age between 18 and 85 years old. * optic neuritis diagnosis ( relative afferent pupillary defect, acquired dyschromatopsia, low vision, prechiasmatic campimetric defect) * 1 month after symptoms started * if is a bilateral simultaneous optic neuritis the eye with the worst vision will be included. * if is a bilateral sequential optic neuritis the eye with lees 1 month evolution will be included. exclusion criteria: * visual field better than 20/60 at the beginning of the study. * history of optic neuritis in the eye under study. * history of additional ophthalmological or neurological pathology that has caused visual loss in the eye under study. * history of previous treatment with intravenous methylprednisolone since the onset of symptoms. * history of high myopia.

Keywords: optic neuritis methylprednisolone retrobulbar injection
duobrii in combination with biologics

Conditions: Psoriasis

Summary: 12 weeks duobrii to patients with 2%-10% bsa who are receiving biologic therapy for at least 24 weeks

a single center, pilot study of 25 subjects to assess 12 weeks duobrii to patients with 2%-10% body surface area who are receiving biologic therapy for at least 24 weeks

Eligibility criteria:
inclusion criteria: 1. male or female adult ≥ 18 years of age; 2. diagnosis of chronic plaque-type 3. psoriasis affecting 2%-10% bsa 4. patient is being treated with biologic therapy for a minimum of 24 weeks 5. able and willing to give written informed consent prior to performance of any study-related procedures exclusion criteria: 1. psoriasis affecting ˂2% or \>10% bsa 2. patient not receiving a biologic agent, or receiving biologic agent \<24weeks 3. received treatment with any topical antipsoriatic drug product within 14 days prior to the baseline visit. 4. has previously used duobrii
a study to examine the effects of an experimental drug on women with breast cancer and metastatic bone disease (mbd)(0822-016)(completed)

Conditions: Breast Cancer; Metastatic Bone Disease

Summary: this is a 4-week study to examine the effects of a new experimental medication on women with breast cancer and established bone metastases. this study will enroll approximately 45 women. the primary hypotheses are: (1) odanacatib will result in a substantial suppression of urinary n-telopeptide of type i collagen (u-ntx) similar to that achieved with an intravenous (iv) infusion of zoledronic acid (za) over 4 weeks of treatment; and (2) odanacatib (mk-0822) will be safe and well tolerated during 4 weeks of treatment.


Eligibility criteria:
inclusion criteria: * patient has histologically or cytologically-confirmed breast cancer * patient has documented skeletal metastases exclusion criteria: * patient is undergoing current oral bisphosphonate therapy, or has a history of oral bisphosphonate use within 6 months of entry into study
different tidal volume on oxygenation, respiratory mechanics, and pulmonary complications in older patients undergoing trendelenburg pneumoperitoneum surgery

Conditions: Trendelenburg; Neumoperitoneum; Oxygenation; Respiratory; Pulmonary

Summary: the investigators want to assess the effect of intraoperative low tidal volume vs intermediate tidal volume on respiratory mechanics, oxygenation and pulmonary complications in older patients undergoing trendelenburg pneumoperitoneum surgery.


Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) physical status i-iii class; * colorectal cancer patients; * elective laparoscopic colorectal surgery; * expected duration of surgery greater than 2 hours. exclusion criteria: * serious complications associated with other systems; * severe cardiac insufficiency; * renal failure; * body mass index (bmi) greater than 30 kg/m2 or less than 18 kg/m2; * the use of low tidal volume and consequent hypercapnia can induce harm; * refusal to participate in the study.
electrical muscle stimulation versus resistive training on physical measures, and fatigue in hemodialysis patients

Conditions: Hemodialysis; Fatigue

Summary: the aim of this study is to compare effect of intradialytic nmes versus resistive training on physical measures and fatigue in hdp.

in this study we will compare between the effect of intradialytic neuromuscular electrical stimulation and resistive training on physical measures, dialysis efficiency and fatigue in hdp. this is first study that will compare between nmes and resistive training in hdp, investigating their effect on physical performance; dialysis efficiency and level of fatigue as previous studies show effect of each intervention alone.

Eligibility criteria:
inclusion criteria: * patients of both sexes, with ckf on hd for more than 3 years. * age between 40 to 55 years old. * bmi is between 25 and 29.9 kg/m2. exclusion criteria: patients who have one of the following contraindications to the interventions or affect the results * cognitive impairment that prevented them from performing the evaluations and who were unable to understand and sign the written informed consent. * stroke * smokers * anemic patients * osteoarticular or disabling musculoskeletal disorders * uncontrolled hypertension (systolic blood pressure\>230 mm hg and diastolic blood pressure\>120 mm hg) * patients with coronary artery disease or heart failure. * diabetic patients * infectious diseases and chest diseases * active smokers' patients with peripheral vascular disease in the lower limbs such as deep vein thrombosis or thromboangiitis
steroid versus mitomycin-c use in pediatric benign recurrent esophageal stricture

Conditions: Esophageal Stricture

Summary: to compare the efficacy of steroid injection versus topical mitomycin-c in the treatment of pediatric benign recurrent esophageal strictures. the rationale for this study is to compare the two therapeutic options in order to measure their effectiveness, in terms of improvement of dysphagia severity score (dss).

after taking approval from the institutional review board of the university; and taking the informed consent from parents, patients fulfilling the inclusion and exclusion criteria will be enrolled in the study. they will be then randomly allocated into two groups; group a and group b. patients in group a will be treated with esophageal dilation with a cre balloon (controlled radial expansion balloon). after adequate dilation of stricture, injection mitomycin will be applied to the narrowest portion of the stricture. patients in group b will be treated with esophageal dilation with a cre balloon in the same manner. after adequate dilation of stricture, triamcinolone injection will be injected into the narrowest portion of the stricture, using a sclerotherapy injector. dysphagia severity score will be noted at start of intervention, at 2 weeks after intervention and at 6 weeks post- intervention.

Eligibility criteria:
inclusion criteria: * patients up to 16 years of age belonging to both genders * patients with single esophageal stricture * patients with benign recurrent esophageal strictures * patients with any etiology for esophageal stricture including; post-corrosive, congenital, post-anastomotic and eosinophilic. exclusion criteria: * patients unfit for anesthesia and/or hemodynamic instability * patients with hemostatic disorder (platelets \ 1.5) * patients who have undergone esophageal surgery in last one month * patients with complications such as; stricture perforation, signs of air leak or mediastinitis * those with hypersensitivity to mitomycin- c * patients with multiple strictures

Keywords: esophageal stricture mitomycin triamcinolone dysphagia
analgesia in öamtc helicopter emergency service in austria

Conditions: Field Physician Care; Analgesics; Hypnotics; Emergencies; Safety; Accident; Trauma, Multiple; Pain, Acute

Summary: a sufficient analgesia in injured or sick people is the main goal of physicians treating a patient. in emergency medicine potent analgesia like ketamine or opioids are routinely used. it is unknown if there are any severe side effects or if the use is safe while in use in a helicopter emergency service equipped with emergency physicians.


Eligibility criteria:
inclusion criteria: * analgesia or use of hypnotics in öamtc air ambulance service in austria 2000-2016 exclusion criteria: * no analgesia, or analgesia use not in connection to öamtc air ambulance service. analgesia given not in the period of examination (2000-2016)
muscle fatigue and scapular sensorimotor system

Conditions: Muscle; Fatigue

Summary: the aims of this study are to investigate the effects of scapular muscle fatigue on scapular joint position sense and neuromuscular performance (scapular muscle strength, the kinematics data and muscle activity of shoulder during scaption (arm elevation in the scapular plane)). the investigators hypothesize that scapular muscle fatigue would increase scapular reposition error and affect neuromuscular performance of the scapular during scaption.


Eligibility criteria:
inclusion criteria: * no shoulder, cervical, and thoracic spine pain within six months * negative for subacromial impingement test * normal range of motion of glenohumeral joint exclusion criteria: * history of dislocation, fracture, or surgery of shoulder joint * history of central nervous system disorder, rheumatoid arthritis, shoulder osteoarthritis, or cervical radiculopathy

Keywords: sensorimotor system scapular joint position sense fatigue
greatest international antiinfective trial with avelox

Conditions: Bronchitis, Chronic; Bronchial Diseases

Summary: the observation period for each patient covered an initial treatment period with avelox® plus optional 2 long-term follow-up periods (6 and 12 months).for each patient, the physician documented data at any initial visit (baseline) and at least one short-term follow-up visit (=initial treatment period).optionally, long-term follow-ups (6 and 12 months) were documented, and a patient questionnaire was filled in.


Eligibility criteria:
inclusion criteria: * outpatients with diagnosis of aecb and decision taken by the investigator to prescribe moxifloxacin exclusion criteria: * exclusion criteria must be read in conjunction with the local product information

Keywords: non-interventional observational nis moxifloxacin mxf avelox aecb
motor learning of a planning task in stroke patients: the maze paradigm measured through time and error as variables

Conditions: Stroke

Summary: the purpose of this study is to investigate the process of acquiring a motor skill subject in post-stroke, comparing them with healthy subjects.

20 post-stroke patients were comprised to the experimental group (eg) and 20 health subjects were included to the control group (cg. inclusion criteria: chronic stroke, single stroke event, lesion in anterior circulation, right handed subjects, meem over 23 points. the task consisted in a maze paradigm, made by pencil and paper, with the non affected side for eg and left upper extremity for cg. the instruction was given to the subjects to complete the task as fast as possible. the study consisted in three phases: acquisition (aq)with 30 trials, transfer (tr, short retention (r1)and long term retention (r2 both with 5 trials.

Eligibility criteria:
inclusion criteria: * age between 40 and 65 * injury in territory of movement earlier, as shown by examination of image and finding medical neurologist * time of injury over 6 months * single vascular event * right handed, by applying the inventory of dominance side of edinburgh mini mental with scores over 23 points exclusion criteria: * aphasia of understanding * instability clinic * other neurological diseases associated (parkinson's disease, dementias, alzheimer)
coronary artery ectasia in elective coronary angiography : predictors, outcomes and management

Conditions: Ectasia; Coronary Artery Disease

Summary: coronary artery ectasia (cae) is the diffuse dilatation of coronary artery. it is defined as a dilatation with a diameter of 1.5 times the adjacent normal coronary artery . its prevalence ranges from 1.2%-4.9% with male to female ratio of 3:1 . coronary ectasia likely represents an exaggerated form of expansive vascular remodelling (i.e. excessive expansive remodelling) in response to atherosclerotic plaque growth . cae is more common in males. hypertension is a risk factor. interestingly, patients with dm have low incidence of cae. this may be due to down regulation of mmp with negative remodelling in response to atherosclerosis . smoking appears to be more common in patients with cae than in those with coronary artery disease (cad). the angiographic classification for cae (described by markis et al.) categorizes the severity based on the extent of coronary arterial involvement: type 1: diffuse ectasia of 2-3 arteries; type 2: diffuse ectasia in one artery and localized in another; type 3: diffuse single arterial ectasia; type 4: localized or segmental ectasia . stable angina is the most common presentation in patients with cae . patients with cae without stenosis had positive results during treadmill exercise tests. st-elevation myocardial infarction (mi) , non-st elevation mi can occur from altered blood flow by distal embolization or occlusion of ectatic segment with thrombus. medical management for cae is a controversial area as there is lack of evidence based medicine, especially the role of antiplatelet versus anticoagulant agents. aspirin was suggested in all patients because of coexistence of cae with obstructive coronary lesions in the great majority of patients and the observed incidence of myocardial infarction, even in patients with isolated coronary ectasia .the role of dual anti platelet therapy has not been evaluated in prospective randomized studies. based on the significant flow disturbances within the ectatic segments, chronic anticoagulation with warfarin as main therapy was suggested


Eligibility criteria:
inclusion criteria: * subjects with suspected cad who are referred for elective coronary angiography exclusion criteria: * previous admission with an acute coronary event, previous pci or cabg. * history of bleeding tendency or those with high bleeding risk according to the has-bled bleeding risk score
cardiopulmonary exercise tests in patients with long covid

Conditions: Long COVID; COVID Long-Haul

Summary: the value of clinical cardiopulmonary exercise testing (cpet) within healthcare settings has been established in the last decade. cpet methods remain highly relevant in the covid-19 endemic phase and should be used to assess those recovering from covid-19 (sars-cov-2) infection. this diagnostic tool could play an integral role in disease prognostication and evaluate the integrative response to incremental exercise. date from such assessments can enable practitioners to characterise cardio-respiratory fitness and identify reasons for physical impairment or abnormal cardio-respiratory function. more than 50% of patients admitted to hospital will experience cardiorespiratory issues and significant morbidity during their recovery and will require significant rehabilitative support. in this context, measurements obtained from an assessment of cardio-respiratory responses to physiological stress could provide insight regarding the integrity of the pulmonary-vascular interface and characterisation of any impairment or abnormal cardio-respiratory function. current approaches to rehabilitation are being developed on existing knowledge from severe acute respiratory syndrome (sars) and acute respiratory distress syndrome (ards) related illness. these provide important insight but do not provide insight into the novel challenges provided by covid-19.


Eligibility criteria:
inclusion criteria: * • aged 18 to 65 years old * diagnosed with covid-19 * still suffering from symptoms of covid-19, 3 months after initial infection * sufficient english language comprehension and cognitive ability to understand the study protocol, give informed consent and follow instructions. exclusion criteria: * • \<18 years of age * admitted to or received treatment from intensive care units * unconfirmed covid-19 test diagnosis * unable to understand verbal or written information in english * achieving a grade 0 or 1 on the pcfs. * unstable angina * uncontrolled hypertension, that is, resting systolic blood pressure (sbp) \>180mmhg, or resting diastolic blood pressure (bp) (dbp) \>110mmhg * orthostatic blood pressure drop of \>20 mmhg with symptoms * significant aortic stenosis (aortic valve area 120 bpm) * acute pericarditis or myocarditis * decompensated hf * third degree (complete) atrioventricular (av) block without pacemaker * recent embolism * acute thrombophlebitis * resting st segment displacement (\>2 mm) * uncontrolled diabetes mellitus * severe orthopaedic conditions that would prohibit exercise * other metabolic conditions, such as acute thyroiditis, hypokalaemia, hyperkalaemia or hypovolaemia (until adequately treated) * severe grade 3 rejection (cardiac transplantation recipients appendix n).