Kornimate/medical-research-clean huggingface dataset:
neoadjuvant chemotherapy in locally advanced breast cancer

Conditions: Breast Cancer

Summary: the purpose of this study is to analyze gene expression signature and immunohistochemical markers associated with clinical and pathological response to neoadjuvant chemotherapy in locally advanced breast cancer.

locally advanced breast cancer is a common condition in development countries. neoadjuvant chemotherapy gives the opportunity to identify genetic signatures associated with objective clinical and pathological complete responses. patients will receive doxorubicin/cyclophosphamide with paclitaxel. tumor samples collected before and after chemotherapy will be analyzed.

Eligibility criteria:
inclusion criteria: * women with locally advanced women breast cancer * histology: ductal ou lobular invasive histology * agreement to take part in the study and signature of the informed consent * clinical condition to receive doxorubicin/cyclophosphamide and paclitaxel * ecog 0 or i exclusion criteria: * not clinical stage iii * inflammatory breast cancer * previous treatment * previous diagnosis of cancer (except basal cell or squamous cell skin carcinoma and non-invasive cervical carcinoma) * pregnancy * absence of clinical condition to receive chemotherapy

Keywords: neoadjuvant chemotherapy advanced breast cancer microarray correlation analysis oncoplastic surgery
study the efficacy of topical antibiotherapy in the prophylaxis of incisional surgical infection in colorectal surgery

Conditions: Surgical Wound Infection; Postoperative Wound Infection; Postoperative Wound Infection Superficial Incisional; Preventive Therapy

Summary: the main objective is to study the efficacy of topical antibiotic therapy with amoxicillin / clavulanic acid in the prevention of surgical wound infection in patients undergoing to colorectal surgery

is a clinical trial phase iv prospective, blind, controlled and random allocation of treatment with the active principle of amoxicillin 1000mg and 200mg clavulanic acid, administered topically and dissolved in 500 ml of saline 0.9%. to demonstrate its effectiveness in the surgical wound infection prophylaxis be used in contaminated surgery and be compared its effectiveness with the topical administration of normal saline only.

Eligibility criteria:
inclusion criteria: * patients over 18 years of age. * patients who require urgent surgical intervention and who come from the emergency service * patients affected by complicated intra-abdominal infection with peritonitis of more than one abdominal compartment or intra-abdominal abscess requiring open surgical intervention. exclusion criteria: * women patients with positive pregnancy test. * patients with primary peritonitis and liver cirrhosis. * patients who have received antibiotic treatment during the 72 hours prior to the surgical intervention (except that administered to ucies as a treatment dose of the same process) * patients allergic to the antibiotic used in the study. * patients who have undergone a surgical procedure of recently opened abdomen (up to 30 days before surgery), a prosthesis of synthetic material (mesh) or to which the surgical wound can not be closed according to the surgeon's criteria. * patients with an unfavorable life prognosis (asa 5).

Keywords: topical antibiotic surgical wound infection prevention of surgical wound infection
study of antidepressants in parkinson's disease

Conditions: Parkinson Disease; Depression

Summary: the purpose of this study is to find out if two antidepressant medications, paroxetine and venlafaxine, can help control depression in parkinson's disease, and if these medications affect the motor symptoms of parkinson's disease such as tremor, stiffness, slowness, and balance.

nearly 50 percent of individuals with parkinson's disease (pd) suffer from depression-a condition that causes disability and can reduce quality of life. the university of rochester medical center is conducting a research study of antidepressant medications to find out more about how to treat depression in pd. antidepressant medications have not been adequately studied in persons with pd. the purpose of this study is to find out if the antidepressant medications paroxetine and venlafaxine can help control depression in pd and whether or not these medications affect the motor symptoms of pd such as tremor, stiffness, slowness, and balance. this is a randomized, double blind, placebo-controlled, 12-week study of paroxetine immediate release (paxil) and venlafaxine extended release (effexor xr). paroxetine and venlafaxine xr are drugs that have been approved by the food and drug administration (fda) and are available by prescription. paroxetine and venlafaxine xr have been shown to be effective in treating depression in the general population. two hundred, twenty-eight persons will be enrolled among 15 medical centers throughout the united states and canada. each person will participate in the trial for 12 weeks. each participant will be randomly assigned to take either paroxetine or venlafaxine, or a placebo.

Eligibility criteria:
inclusion criteria: to be eligible you must be: * 30 years old or older * diagnosed with parkinson's disease * experiencing symptoms of depression such as sadness, decreased energy, or problems sleeping

Keywords: parkinson disease depression parkinson's disease paroxetine venlafaxine antidepressant
a study to investigate the effects of bms-986278 on drospirenone and ethinyl estradiol drug levels in healthy female participants

Conditions: Healthy Volunteers

Summary: the purpose of the study is to assess the effects of bms-986278 on drospirenone (drsp) and ethinyl estradiol (ee) when administered as a combined oral contraceptive in healthy female participants.


Eligibility criteria:
inclusion criteria: * body mass index between 18.0 and 32.0 kilograms/meter square (kg/m\^2), inclusive. * body weight ≥ 45 kg. * healthy females, as determined by physical examination and clinical laboratory assessments (including chemistry, hematology, coagulation, and urinalysis) within the normal range at the screening visit and on day -1, as applicable. exclusion criteria: * any significant acute or chronic medical illness. * any gastrointestinal (gi) disease or surgery (including cholecystectomy) or other procedures (eg, bariatric procedures) that could affect drug absorption, distribution, metabolism, and excretion. note: appendectomy is allowed (12 months prior to screening). * any other clinically significant medical, psychiatric, and/or social reason, or other active issues, especially eye issues, as determined by the investigator. note: other protocol-defined inclusion/exclusion criteria apply.

Keywords: pharmacokinetics bms-986278 hormonal contraceptives ethinyl estradiol drospirenone pulmonary fibrosis
cerebral antibiotics distribution after acute brain injury

Conditions: Bacterial Infection; Brain Injury

Summary: the aim of the study is to explore the distribution of antibiotics in the brain after an acute brain injury because brain infections treatment is still an health care problem.


Eligibility criteria:
inclusion criteria: * acute brain injury * patient who receive an antibiotic for an infection or prophylaxy * glasgow coma score \< 8 exclusion criteria: * age \< 18 years old * pregnant woman * hcv, hiv, hbv infection
eosinophil indices in patients with acute heart failure

Conditions: Acute Heart Failure; Reduced Systolic Function

Summary: all consecutive patients admitted to the intensive care unit (icu) with adhf between january 2017 and december 2021 were enrolled in this retrospective study. all-cause mortality and mace were assessed with respect to relationships with eosinophil indices, including neutrophil-to-eosinophil ratio (ner), leukocyte-to-eosinophil ratio (ler), eosinophil-to-lymphocyte ratio (elr), and eosinophil-to-monocyte ratio (emr).

all consecutive patients admitted to the intensive care unit (icu) with adhf and reduced ef between january 2017 and december 2021 were enrolled in this retrospective study. hfref was defined as having an lvef of ≤40%. demographic data were retrieved from patient charts and the institutional digital database. patients with an lvef \>40%, nyha class i and ii subjects, those with advanced liver, kidney diseases or malignancies, patients in whom life expectancy was extremely short and patients with autoimmune, allergic, or infectious diseases that affect the eosinophil indices were not included in the study. the study was approved by the local ethics committee. conventional guidelines had been followed for the in-hospital treatment of all patients with adhf, including loop diuretics, vasodilators, inotropes/vasopressors \[9\]. blood tests including complete blood count, blood urea nitrogen and creatinine, electrolytes, liver enzymes, and nt-pro bnp were ordered upon admission to the icu. all patients underwent transthoracic echocardiography. lvef was measured with 2-dimensional echocardiography via the modified simpson method \[10\]. data concerning 6-month all-cause mortality and mace were retrieved from the institutional digital database. the definition of mace was the composite of total death and re-hospitalization for hf within 6 months of initial hospitalization. the primary outcome measure of this study was all-cause mortality within the first 6 months of index hospitalization and its relationship with eosinophil indices, including ner, ler, elr and emr. the secondary outcome measure of this study was the assessment of mace within the first 6 months of index hospitalization and its association with eosinophil indices.

Eligibility criteria:
inclusion criteria: * patients who admitted to the intensive care unit (icu) with acute decompensated heart failure and reduced ejection fraction (\<%40) exclusion criteria: * patients with an lvef \>40%, nyha class i and ii subjects, those with advanced liver, kidney diseases or malignancies, patients in whom life expectancy was extremely short and patients with autoimmune, allergic, or infectious diseases

Keywords: eosinophil indices, acute heart failure
development of a model to predict the risk of venous thromboembolic events in patients with metastatic bronchopulmonary cancer

Conditions: Metastatic Bronchopulmonary Cancer

Summary: venous thrombo-embolism (vte) is a frequent and serious complication of cancer. however, predictive tools for vte in cancer patients is lacking. in patients with metastatic broncho-pulmonarycancer, biochemical characteristics might help to identify patients at high risk for vte. the aim of this study is to derive a predictive score combining clinical and biochemical variable that predict vte in metastatic broncho-pulmonary cancer.

venous thrombo-embolism (vte) is a frequent and serious complication of cancer. however, predictive tools for vte in cancer patients is lacking. in patients with metastatic broncho-pulmonarycancer, biochemical characteristics might help to identify patients at high risk for vte, particularly in adenocarcinoma. the aim of this study is to derive a predictive score combining clinical and biochemical variable that predict vte in metastatic broncho-pulmonary cancer.

Eligibility criteria:
inclusion criteria: * metastatic broncho-pulmonary cancer * age ≥18 years * who are eligible for chemotherapy * non opposition obtained exclusion criteria: * age \<18 years * pregnancy, breast feeding * vte in the past 6 months or at the time of cancer diagnosis * surgery in the past 3 months * refusal to participate
adipose tissue extract and platelet-rich plasma use for wound healing

Conditions: Wound Healing Disturbance of

Summary: adipose tissue extract (ate) has been found to be an autologous source of growth factors with proven in vitro angiogenic and adipogenic properties.it is obtained by a simple lipoaspirate procedure. we sought to compare the effect of ate with another known source, platelet-rich plasma to compare the wound healing characteristics on skin graft donor sites.

the investigators enrolled 24 participants with an indication for skin graft. two or more split-thickness grafts are harvested per patient, one serving as control and the other as experimental. the experimental sites were covered with either autologous prp gel or ate prepared in the or, which was selected in an unblinded manner due to surgical theater convenience. however, donor sites were randomized through a computer generator. covered with a semiocclusive film, wounds were separated and followed up on days 3,5,7,10,14 for wound healing and 30 and 60 for scar evaluation. digital photography and specto-photocutometry was employed to know the hemoglobin and melanin content of the wounds, and custom-made software was used to calculate the percentage of wound re-epithelialization.

Eligibility criteria:
inclusion criteria: * donor site indication exclusion criteria: * immunosupressive states * terminal renal insufficiency * pregnancy * coagulation dyscrasias * active infection in donor site
copd circuit exercise

Conditions: OSA; Covid19; Residual Symptoms of COVID 19; COPD

Summary: this study is being done to understand body's response to hybrid home-based and on-site rehabilitation program utilizing individually tailored exercises throughout a total of 18 sessions with 12 of them occurring onsite, in people with and without chronic respiratory diseases, such as chronic obstructive pulmonary disease (copd) and obstructive sleep apnea (osa) and in individuals recovered from covid-19. exercise training programs vary widely for people with copd, osa, and during prolonged recovery from covid infection. this study will help identify if this program is helpful to address muscle loss and fatigue specifically in populations with and without chronic respiratory diseases.


Eligibility criteria:
inclusion criteria: * ability to walk, sit down and stand up independently * age 30 - 85 years * ability to lay in supine or elevated position for up to 3 hours * diagnosis of moderate to very severe chronic airflow limitation and compliant to the following criteria: fev1 \< 70% of reference fev1 -or- obstructive sleep apnea (osa) -or- 2 weeks post-recovered\* from laboratory confirmed case of covid ● willingness and ability to comply with the protocol \*recovered is defined according to brazos county health district as someone who has been fever-free for 24 hours without fever-reducing medications, and it has been 10 days after onset of symptoms. inclusion criteria control subjects * healthy male or female according to the investigator's or appointed staff's judgment * ability to walk, sit down and stand up independently * age 30 - 85 years * ability to lay in supine or elevated position for up to 3 hours * no diagnosis of chronic lung disease * willingness and ability to comply with the protocol exclusion criteria: * unable to exercise due to physical limitations (i.e. neuromuscular and/or orthopedic disorders) * established diagnosis of malignancy * presence of acute illness or metabolically unstable chronic illness * presence of fever within the last 3 days. * expected to have surgery within 1 month of screening or during exercise training * any other condition according to the pi or research staff that was found during the screening visit, that would interfere with the study or safety of the patient. * previous injury that could interfere with participation in resistance exercise protocol. * failure to give informed consent or investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements. * (possible) pregnancy. * already enrolled in another clinical trial and that clinical trial interferes with participating in this study. when during the period from enrollment to the test day any condition causing the subject to not meet inclusion criteria or to meet exclusion criteria, the subject will be excluded from the study.
open lung approach during general anaesthesia to prevent post-operative pulmonary complications

Conditions: Postoperative Complications

Summary: the hypothesis of this study is that the "open lung approach" ( recruitment and peep) during general anaesthesia reduces atelectasis formation and improves respiratory function in the immediate post-operative period after major abdominal surgery. this is a prospective, randomized, controlled clinical-trial,performed in patients undergoing major abdominal surgery, to compare the effects on the post-operative pulmonary complications of two different intraoperative ventilatory strategies during general anaesthesia: 1- control group: peep 0 cmh2o without recruitment manoeuvre; 2- treatment group:recruitment manoeuvre (after intubation and before extubation) and peep 10 cmh2o in the post-operative period the following variables will be recorded at the first, third and fifth postoperative day: 1- gas-exchange in air; 2- chest x-ray for atelectasis evaluation; 3- signs of pulmonary complication (cough, secretions, dyspnea, thoracic pain)


Eligibility criteria:
inclusion criteria: * patients with asa 1, 2 and 3 * age higher than 18 years * major abdominal surgery * general anesthesia exclusion criteria: * copd with fev1 lower than 50% * ischemic cardiopathy * loco-regional anesthesia alone * minor abdominal surgery * laparoscopic surgery
caries-preventive effect of a dentifrice containing 5,000 ppm fluoride in orthodontic patients

Conditions: Dental Caries

Summary: aim: to evaluate the efficacy of daily tooth brushing with high concentrated fluoride dentifrice on white spot lesion (wsl) formation in adolescents during treatment with fixed orthodontic appliances (foa). the null hypothesis is that neither incidence nor severity of lesions would differ from a control group using standard fluoride dentifrice. subjects and methods: 420 healthy consecutive 11-16 year-old patients referred to 4 orthodontic specialist clinics are randomized to use either a dentifrice containing 5.000 ppm fluoride or a regular dentifrice with 1.450 ppm sodium fluoride. to be eligible for inclusion, the patients are scheduled for bimaxillary treatment with foa for an expected duration of at least 1 year. all are instructed to use 0.25 gram dentifrice and brush their teeth during 2 minutes twice daily during the entire period of treatment. before bonding, and after polishing with a rubber cup and non-fluoride pumice paste, 3 digital photos of the maxillary incisors, canines and premolars are taken. at debonding, remaining composite material on the surfaces is removed with a slow rotating carbide bur followed by polishing with a rubber cup and pumice paste. a new series of frontal and lateral digital photos is thereafter exposed. the primary outcome measure is the incidence and severity of wsl as registered separately by two blinded experienced and calibrated clinicians according to a validated index. a random sample of 50 cases is re-assessed to check intra- and inter-examiner reliability. the intervention is indended run throughout the full duration of the orthodontic treatment, varying between 18 and 24 months.

not desired

Eligibility criteria:
inclusion criteria: * healthy * bi-maxillary treatment with fixed orthodontic appliances for at least 1 year exclusion criteria: * poor oral hygiene (not being able to brush their teeth) * recent high caries activity

Keywords: caries prevention orthodontics fixed appliances adolescents
standard antibiotic versus enhanced prophylactic measures on rate of urinary tract infection after flexible ureteroscopy

Conditions: Urinary Tract Infections

Summary: background and aim: urinary tract infections (utis) are commonly seen after flexible ureteroscopy. prevention of utis remains controversial. the present randomized study aimed to compare the rate of post-procedural uti in patients subjected to the standard antibiotic prophylaxis alone versus enhanced prophylactic measures. patients and methods: the study included 100 patients subjected to furs for management of ureteral and/or renal stones. patients were equally and randomly allocated into one of the two treatment groups using randomly computer-generated allocation tables and concealed envelope technique. treatment groups included standard antibiotic prophylaxis group and enhanced prophylaxis group. patients in the standard antibiotic prophylaxis group iv fluoroquinolone 1 hour preoperatively and oral antibiotics were used for 24h postoperatively. in the enhanced prophylaxis group, patients had urine culture 10 days before the procedure. in addition to the antibiotic prophylaxis, hydrophilic-coated ureteral access sheaths were systematically used.


Eligibility criteria:
inclusion criteria: * all patients subjected to flexible ureteroscopy for management of ureteral and/or renal stones. exclusion criteria: * symptomatic urinary tract infection. * use of rigid ureteroscopy and antegrade ureteroscopy.
effect of intravitreal bevacizumab on corneal endothelium

Conditions: Corneal Endothelial Cell Loss

Summary: to evaluate corneal endothelium cell change after intravitreal bevacizumab injection

intravitreal bevacizumab has been used by retinal specialist in treatment many retinal diseases. although it not approved by fda for treatment. in many in vitro studies, its showed saftey in the eyes especially for corneal endothelium cells, that important cells to keep cornea clear. this study use confoscan-corneal confocal microsope to evaluate corneal endothelium before and after intravitreal bevacizumab injection in routine retinal disease at 6 month follow up.

Eligibility criteria:
inclusion criteria: * aged between 20 and 80 years old * can come to regular follow up at 6 month * signed written consent forms * not have corneal scar, or glaucoma * history of treatment with laser or anti-vegf therapy in 3 month prior to recruit * high risk in cerebrovascular and cardiovascular diseases * pregnancy and breastfeeding * can undergo confocal microspopy exclusion criteria: * history of intraocular surgery or ocular trauma during study

Keywords: corneal endothelium bevacizumab intravitreal injection confoscan