Kornimate/medical-research-clean huggingface dataset:
early diagnosis and prediction of maternal and neonatal diseases:

Conditions: Pregnancy-Related and Neonatal Disorders

Summary: this is a multi-center, clinical study designed to evaluate the application and effectiveness of an ai-assisted predictive model for identifying maternal and neonatal diseases, leveraging multimodal health data.

maternal and neonatal health significantly impact the well-being of both mothers and infants. early screening, diagnosis, and intervention are crucial for preventing the onset and progression of pregnancy-related diseases and neonatal conditions. in clinical practice, obstetricians and pediatricians often need to integrate a wide range of patient data, including demographic information, medical history, biochemical markers such as blood glucose and lipid levels, as well as various imaging data such as ultrasounds, fetal monitoring, and laboratory test results, to make an accurate diagnosis and develop an appropriate care plan. in an era where precision and personalized medicine are at the forefront of healthcare, the early detection and diagnosis of maternal and neonatal diseases, as well as the selection of suitable diagnostic and therapeutic strategies, have become significant challenges in clinical settings. recent advancements in medical imaging and data analysis techniques have greatly enhanced the accuracy and effectiveness of maternal and neonatal disease diagnosis. this study aims to develop an ai-assisted decision-making system by integrating multimodal data from electronic medical records, imaging, and laboratory results, in combination with deep learning techniques. the objective is to improve diagnostic accuracy, streamline clinical workflows, and provide more personalized care options for mothers and infants. ultimately, this system seeks to enhance health outcomes and improve the overall quality of life for both mothers and their newborns.

Eligibility criteria:
inclusion criteria: 1. pregnant women aged 18 to 45 years. 2. women who have received prenatal care at participating centers (e.g., hospitals or clinics). 3. availability of comprehensive electronic health records, including prenatal care data, laboratory results, and imaging records. 4. willingness to provide consent for participation in the study and the use of historical health data for analysis. exclusion criteria: 1. women under 18 or over 45 years old. 2. participants with insufficient follow-up data or missing critical clinical information required for predictive modeling.

Keywords: maternal and neonatal health early disease prediction ai-assisted diagnosis
the epidemiology of tst change in korea

Conditions: Tuberculosis; Latent Tuberculosis

Summary: tst will be analyzed in young general population in korea. young adults undertake tst as cdc recommendation. participants with chest radiograph showing active tb lesion are excluded from this study.

enroll criteria * a term of whole military conscripts per year in one reserve force battalion * military conscripts gather from all around area in korea randomly * each participant undertake a chest x-ray (cxr) and blood tests including human immunodeficiency virus (hiv) at the start of initiatory training. exclusion criteria * chest x-ray suggesting active tb * hiv positive in serology design * after giving informed consent, all participants receive one-step tst following standard procedures. * the largest transverse diameter of induration is measured 48-72hr after injection. * the investigator and these trained nurses were blinded to the status of their demographic characteristics.

Eligibility criteria:
inclusion criteria: * military conscripts age 18-29 years old exclusion criteria: * chest x-ray suggests active tb * positive hiv in serology
post approval study (pas) of the optimizer smart and ccm therapy

Conditions: Heart Failure

Summary: the optimizer smart post-approval study is a prospective, multi-center, non-randomized, single arm open label study of 620 subjects receiving an optimizer implant as standard of care. patients to be included will have nyha functional class iii symptoms and a left ventricular ejection fraction of 25-45%

the impulse dynamics optimizer smart pre-market application (pma) clinical data confirmed that ccm therapy delivered with the optimizer meaningfully improved health outcomes in patients with nyha class iii heart failure symptoms and left ventricular ejection fraction of 25-45%. ccm has shown significant improvements in quality of life measures, with an average improvement of \>11 points in mlhwfq incremental to the improvement of a randomized control group with no device. six minute hall walk and functional class also showed improvements in the pma data. the post-approval study (pas) protocol has been designed to evaluate long term safety and efficacy of the optimizer smart in a real-world setting.

Eligibility criteria:
inclusion criteria: 1. patient provides written authorization and/or consent per institution and geographical requirements 2. male or non-pregnant female, aged 18 or older 3. left ventricular ejection fraction of 25-45% (inclusive, per site assessment) 4. nyha class iii heart failure symptoms 5. stated willingness to comply with all study procedures and availability for the duration of the study 6. patient has been treated with guideline-directed medical therapy exclusion criteria: 1. primary heart failure due to uncorrected mitral valve disease, or mitral valve repair or clip within 90 days of implant 2. iv inotropes, hemofiltration, or any form of positive inotropic support within 30 days prior to implant 3. myocardial infarction within 90 days prior to implant 4. undergone a cabg procedure within 90 days or a ptca procedure within 30 days of implant 5. prior heart transplant or ventricular assist device 6. mechanical tricuspid valve 7. receiving cardiac resynchronization therapy (crt) or has a class i indication for crt implantation according to the accf/aha/hrs guidelines for device-based therapy 8. participating in a cardiac investigational study at the same time 9. patient is in a vulnerable population (such as significant mental disability, prisoner) that in the judgement of the pi impedes ability to provide informed consent.

Keywords: optimizer heart failure ccm post-approval study nyha class iii fix-hf-5c chronic heart failure ejection fraction between 25 and 45 cardiac contractility modulation
pilot study evaluating the elasticity and shear wave modulus (stiffness) of the median nerve in patients with mild to moderate idiopathic carpal tunnel syndrome receiving omt and conservative therapy

Conditions: Carpal Tunnel Syndrome

Summary: to evaluate and quantify changes in the elasticity and shear wave modulus (stiffness) of the median nerve in patients diagnosed with mild to moderate carpal tunnel syndrome following osteopathic manipulative therapy.


Eligibility criteria:
inclusion criteria: * diagnosis of unilateral or bilateral mild to moderate carpal tunnel syndrome, based on recent emg findings exclusion criteria: * history of undergoing recent physical therapy for treatment of carpal tunnel syndrome * history of wrist trauma or surgery * hypothyroidism * severe cts that has progressed to muscle atrophy * systemic disease or condition including but not limited to diabetes mellitus, thyroid disorders, rheumatoid disorders, paget's bone disease, gout, myxedema, multiple myeloma, acromegaly, hepatic disease, dialysis patients, or other diseases or conditions in which peripheral neuropathies are common. * secondary cause of cts such as a ganglion cyst, mass, or an accessory muscle shown by us or mri of the affected wrist. * bifid median nerve as shown by us or mri of the affected wrist * pregnant or recently postpartum
synovial fluid bank from arthritic patients

Conditions: Arthritis

Summary: the objectives of this group project is to collect synovial fluid (sf) and paired sera and carry out preclinical studies to evaluate, alone or by combination testings, the potential of novel biomarkers for their prevalence and diagnostic/prognostic values in patients with arthritis, and to determine how therapeutic intervention regulate their levels.

our group has developed interdisciplinary expertise in biomarkers related to distinct aspects of inflammation-induced joint damage, most notably those associated with degradation of components of the extracellular matrix, bone loss, or associated with post-translational changes on protease inhibitors. the objectives of this group project is to collect sf and paired sera and carry out preclinical studies to evaluate, alone or by combination testings, the potential of novel biomarkers for their prevalence and diagnostic/prognostic values in patients with arthritis, and to determine how therapeutic intervention regulate their levels. more specifically, we will study (1) biomarkers associated with osteoclastic bone resorption and synthesis/degradation of cartilage, (2) inhibitors of enzymes (calpastatin) that are preferentially targeted by rheumatoid patients, as well as (3) enzymes (e.g. matrix metalloproteinases (mmps)) responsible for the cleavage of components of the articular cartilage. finally, we propose to characterize the repertoire of specific active proteases in the sf of arthritic patients concomitantly to the use biomarkers (neoepitopes of cleaved collagens) previously associated with cartilage destruction and synthesis to identify new targets for the development of protease inhibitors for the treatment of arthritis. furthermore, our project will also provide the opportunity to test the potential of measuring the net proteolytic activity by fluorescent-activated substrate conversion as a method of monitoring disease activity and treatment efficiency in a clinical setting.

Eligibility criteria:
inclusion criteria: * significant joint effusion exclusion criteria: * hemorrhagic effusion * traumatic effusion * less than 3 ml total of collected fluid (used for routine analysis and culture) * inability or refusal to consent

Keywords: synovial fluid arthritis paired serum/synovial fluid samples
study of the quality of lung resection

Conditions: Bronchial Cancer

Summary: in 2009, centres that carried out lung resection for cancer were required to obtain authorization following the first cancer plan. one of the criteria to obtain authorization was the volume of activity: the centre had to carry out at least 30 lung resections per year for cancer. five years later, it would be useful to know the impact of this new organization of oncology on the quality of care. to answer this question, the pmsi database is an ideal source of an indicator of quality: in-hospital mortality. this observational cohort study will be conducted using the national pmsi database with data covering the period from 1st january 2005 to 31st december 2013. it will be limited to hospitalization for lung resection. the time will be divided into 3 periods: 2005-2007, 2008-2010 and 2011-2013; the period 2008-2010 includes the implementation of authorizations for cancer surgery.


Eligibility criteria:
inclusion criteria: any patients who underwent lung resection for bronchial cancer will be included in this study. the pmsi (programme de médicalisation des systèmes d'information) database will be searched for all patients with: * a principal diagnosis of icd10 (international classification of diseases) codes for bronchial cancer * and ccam (classification commune des actes médicaux ) procedure codes for lung resection (segmentectomy, lobectomy, pneumonectomy). exclusion criteria: * none
a prospective, observational study on the effectiveness of new antiepileptic drugs as first bitherapy in the daily clinical practice

Conditions: Focal Epilepsy

Summary: assessment of the efficacy under daily clinical conditions of the new antiepileptic drugs (aeds) gabapentin, lamotrigine, levetiracetam, oxcarbazepine, pregabalin, tiagabine and topiramate, used as first-choice combination therapy (bitherapy) in patients with focal epilepsy.


Eligibility criteria:
inclusion criteria: * aged 18 years or older. * diagnosis of focal epilepsy. * previous failure of one or more aeds used in monotherapy. * background treatment with an antiepileptic drug. * the investigator has considered that the patient must start treatment with some of the seven new aeds in combination therapy: lamotrigine, levetiracetam, gabapentin, oxcarbazepine, pregabalin, tiagabine and/or topiramate. * history of seizures in the patient in the past 3 months. * the patient or legal guardian must be able to understand the characteristics of the study and fill in the seizure diaries. * written informed consent. exclusion criteria: * inability to comply with the study requirements. * diagnosis of generalized epilepsy or inability to establish if focal or generalized. * presence of serious or uncontrolled systemic disease, serious psychiatric disease or progressive neurological disease. * history of alcoholism, drug addiction, or abuse of medicines in the past two years. * psychogenic seizures in the two years prior to inclusion in the study.

Keywords: epilepsy antiepileptic biotherapy
effects of transcranial direct current stimulation (tdcs) in gambling disorder

Conditions: Pathological Gambling

Summary: gambling disorder is associated to high impulsivity and excessive risk-taking behaviour. these behavioural characteristics related to addiction are linked to cognitive processes in specific brain areas located in the prefrontal cortex (pfc). with the aim of studying the role of pfc in gambling disorder, the investigators employ transcranial current direct stimulation (tdcs), a noninvasive brain stimulation technique that applies a very weak electrical current to the superficial areas of the brain. the clinical phase of the research consists on studying the effects of tdcs in combination with cognitive behavioural therapy (cbt) in patients that attend the united kingdom (uk) national problem gambling clinic. the main objective of the project is to investigate whether the combination of tdcs and cbt can help to decrease impulsivity and risk-taking behaviour and therefore improve the treatment for gambling disorder.

the investigators aim to have a total of 32 participants diagnosed with gambling disorder with the problem gambling severity index (pgsi). there will be 16 participants per group having two different groups (real stimulation and sham). real stimulation involves the application of tdcs stimulation and sham condition is used as a control (similar to a placebo). participants will attend 8 weekly sessions where they receive tdcs stimulation for 20 minutes, while complete cantab cognitive tasks that measure cognitive processes such us control inhibition and risk-taking behaviour. electroencephalography (eeg) activity will be measured before and after tdcs. participants will also complete cognitive questionnaires (pathological gambling adapted yale-brown obsessive compulsive scale (pg-ybocs), gambling symptom assessment scale (g-sas) and visual analogue scale (vas) for gambling cravings.

Eligibility criteria:
inclusion criteria: * male or females between 18-65 years old diagnosed with disordered gambling based on the problem gambling severity index (pgsi) who can speak and read english and don't have any of the exclusion criteria. exclusion criteria: 1. history or evidence of chronic or residual neurological disease. 2. a pacemaker or deep brain stimulation. 3. metal implants in head or neck area (e.g. postoperative clips after intracerebral aneurysm; arterial aneurysm in the vascular system, implantation of an artificial hearing aid). 4. intracerebral ischemia/history of bleeding. 5. prior evidence of epileptic seizures, history of epilepsy. 6. history of head injury with loss of consciousness. 7. any serious medical conditions (disease of the internal organs). 8. pregnancy or breast-feeding. 9. negative prescreening from the clinic psychiatrist.
improving adolescent health outcomes through preventive care transformation

Conditions: Sexually Transmitted Diseases; Depression Diagnosis; Substance Use Disorders

Summary: preventive care for adolescents is vitally important for maximizing their health and well-being. unfortunately, pediatric primary care frequently fails to meet the preventive needs of adolescents as demonstrated by poor health outcomes for this population. in this grant application, the investigators propose to expand an existing computer decision support system (cdss) into the investigators adolescent primary care practices for the purpose of implementing a comprehensive, and developmentally appropriate, screening and physician decision support process. prior work completed by the investigators research group has demonstrated the feasibility of using cdss to implement and evaluate clinical guidelines. the investigators seek to positively impact the effectiveness of preventative primary care visits by applying this previous success to the investigators adolescent practice. the investigators hypothesize that the implementation of developmentally appropriate universal screening practices, using tablet technology, and enhanced physician decision support regarding clinically relevant guidelines for all annual adolescent preventive care visits will result in better health outcomes, including higher rates of adherence to physician recommendations and improved patient functioning. the specific research aims of this proposal are: aim 1: expand and modify an existing cdss to include an adolescent preventive care module comprised of developmentally appropriate screening tools for adolescents aged 11 to 21 years and tailored evidence-based clinical decision support for physicians. aim 2: evaluate the impact of the adolescent preventive care module on the identification of specific mental and physical health problems and treatment outcomes in an adolescent primary health care setting. adolescent primary care issues of interest for this project include sexually transmitted infection (sti), depression, substance use and human papillomavirus (hpv) immunization. the investigators expect this project to improve the health outcomes of adolescents, guide future efforts to implement universal screening and cdss in a variety of primary care settings, and provide additional evidence to support broad-based electronic screening and computerized decision support for use in preventive care as a method for improving adolescent health.


Eligibility criteria:
inclusion criteria: * 11-21 years * attending primary care clinic exclusion criteria: * none

Keywords: adolescent screening primary care computer decision support systems
daily physical activity in myelomeningocele

Conditions: Physical Activity

Summary: obesity is getting more common and challenging to treat in children and adolescents with myelomeningocele. therefore, it is becoming more important to determine daily physical activity in these patients. daily walking performance and average steps per day in patients with low lumbar and sacral level myelomeningocele are shown to not differ from healthy controls. step counts can not reflect all torsional accelerations associated with daily living activities. omnidirectional accelerometers provide all types of body movement outputs and give detailed parameters of physical activity level and energy expenditure. there is no data about energy expenditure and physical activity level of the patients with myelomeningocele in daily routine. this study aims to quantify energy expenditure and physical activity of children and adolescents with low lumbar and sacral level myelomeningocele.

children and adolescents with low lumbar and sacral level myelomeningocele, and age-, sex-, and bmi-matched controls were included. omnidirectional accelerometer monitor (actical®) was used to assess activity energy expenditure and daily durations spent in sedentary, light activity and moderate to vigorous physical activity (mvpa).

Eligibility criteria:
inclusion criteria: * patients diagnosed myelomeningocele with the neurological level between l5 and s3 * patients aged between 6 and 16 years * independent ambulatory patients without an assistive device or braces exclusion criteria: * presence of disorders other than myelomeningocele that affect physical activity or exercise (e.g. rheumatic disease, cardiovascular disease) * unable to wear omnidirectional accelerometer monitor (actical®, philips respironics) for five consecutive days

Keywords: activity energy expenditure moderate to vigorous physical activity myelomeningocele
a new protocol for the management of dental erosion in rugby players

Conditions: Dental Erosion

Summary: the aim of the present study is to provide a new domiciliary oral care treatment for enamel remineralization in rugby players patients using mouthguards. patients selected for the study will be randomly divided and allocated in two groups according to the treatment: * group 1: scaling and root planing (srp) + biorepair total protective repair toothpaste for home oral hygiene twice a day * group 2: scaling and root planing (srp) + biorepair total protective repair toothpaste + biorepair mouthwash (3 in 1) for home oral hygiene twice a day patients will be given instructions for the cleaning of their mouthguards. the periodontal evaluation will be conducted before srp, after 15, 30 and 90 days. the periodontal indices collected will be: pi, bop, schiff air index, bewe index and dental sensitivity (vas scale).

the aim of the present study is to provide a new domiciliary oral care treatment for enamel remineralization in rugby players patients using mouthguards and to prevent further worsening of dental erosion. patients selected for the study will sign the informed consent and will be randomly divided and allocated into two groups: * group 1: srp + biorepair total protective repair toothpaste for home oral hygiene twice a day * group 2: srp + biorepair total protective repair toothpaste + biorepair mouthwash (3 in 1) for home oral hygiene twice a day patients will be given instructions for the cleaning of their mouthguards. the periodontal evaluation will be conducted before srp, after 15, 30 and 90 days. the periodontal indices collected will be: pi, bop, schiff air index, bewe index and dental sensitivity (vas scale).

Eligibility criteria:
inclusion criteria: * patients willing to participate to the study * rugby players exclusion criteria: * patients with cardiac pacemaker * patients suffering from neurological disorders * patients suffering from psychological disorders * pregnant or breastfeeding women

Keywords: enamel remineralization