Kornimate/medical-research-clean huggingface dataset:
effect of aromatherapy on postoperative pain: randomized clinical trial

Conditions: Acute Pain; Perioperative/Postoperative Complications; CAM; Nurse's Role

Summary: introduction: pain is one of the main complications in the immediate postoperative period that can harm the patient and can be managed through pharmacological and non-pharmacological methods. complementary integrative health practices are non-pharmacological methods that use therapeutic resources based on traditional knowledge to treat symptoms. among them, aromatherapy stands out, which consists of the use of essential oils through inhalation or topical application for therapeutic purposes and which can be used as a nursing intervention, especially in the context of perioperative care. objective: to evaluate the effect of aromatherapy on postoperative pain in adult patients in the immediate postoperative period. method: this is a randomized controlled clinical trial that will be carried out in a teaching hospital. the project was submitted to the research ethics committees of the school of nursing of the university of sao paulo and the university of sao paulo hospital. adult patients undergoing elective surgical procedures of any surgical specialty under anesthesia of any type will be included. individuals diagnosed with dementia, cognitive impairment or chronic pain will be excluded; individuals with a history of asthma, allergic bronchitis, chronic obstructive pulmonary disease, contact dermatitis or allergy to cosmetics with lavender fragrance, or hypersensitivity to the compounds used in the intervention; procedure for reoperation for any reason. the intervention will consist of the application of aromatherapy with 2% lavender essential oil through the skin and inhalation by a nurse, associated with usual care, in the immediate postoperative period; the placebo group will only receive the application of grape seed vegetable oil associated with usual care. a numerical verbal scale will be applied to assess pain and vital parameters will be measured upon patient admission, every fifteen minutes in the first hour and every thirty minutes in the second hour or after 15, 30, 45, 60 minutes, 1h30 minutes and 2 hours after applying the intervention, in the post-anesthesia recovery room. possible associations between variables will be verified using pearson's chi-square or fisher's exact tests. comparison between means or medians will be made using the student's t or mann-whitney tests, depending on the normality determined according to the kolmogorov-smirnov test. the significance level adopted will be 5%.


Eligibility criteria:
inclusion criteria: * adult patients undergoing elective surgical procedures of any surgical specialty under anesthesia of any type exclusion criteria: * individuals diagnosed with dementia, cognitive impairment or chronic pain; * individuals with a history of asthma, allergic bronchitis, chronic obstructive pulmonary disease, contact dermatitis or allergy to cosmetics with lavender fragrance, or hypersensitivity to the compounds used in the intervention; * procedure for reoperation for any reason

Keywords: acute pain perioperative nursing aromatherapy
behavioral activation for treatment of depression in adolescents with autism

Conditions: Depression; Autism

Summary: in this study, the investigators will examine the feasibility, acceptability, and preliminary efficacy of a novel, behavior-based approach for treatment of depression symptoms in adolescents with autism spectrum disorder or asd (i.e., behavioral activation for adolescents with asd, ba-a).

in this study, the investigators will examine the feasibility, acceptability, and preliminary efficacy of a novel, behavior-based approach for treatment of depression symptoms in adolescents with asd (i.e., behavioral activation for adolescents with asd, ba-a). ba-a is a 12-session manualized treatment that utilizes established behavioral activation strategies and incorporates common mental health treatment adaptations for young people with asd. for this project, the investigators will pilot ba-a with 23 adolescents (12-17 years of age) with asd and clinically significant depression symptoms. to investigate ba-a feasibility, the investigators will examine treatment session attendance and therapist treatment fidelity. to investigate ba-a acceptability, the investigators will utilize a mixed methods approach, inclusive of surveys and qualitative interviews, to inform ba-a protocol refinement. to investigate ba-a preliminary efficacy, the investigators will examine depression symptoms, as well as secondary outcome measures, at pre-treatment, post-treatment, and one-month follow-up.

Eligibility criteria:
inclusion criteria: * previous diagnosis of asd by a qualified health care provider * children's depression inventory, second edition (cdi2) parent-report and/or self-report t- score ≥ 65 * wechsler abbreviated scale of intelligence, second edition (wasi-ii) full scale iq, two-subtest form (fsiq-2) ≥ 85 * participation of a parent or legal guardian living in the same home who can read and write in english at or above the fifth grade level * teens must have been on a stable dose of medications for mood, anxiety, or behavior for at least three months prior to enrollment and have no planned medication changes during study period * not actively participating in another psychotherapy during study period exclusion criteria: * high suicide risk * physical aggression * psychotic and/or manic symptoms
a trial of n-3 pufa-enriched ready to use therapeutic food for childhood severe malnutrition

Conditions: Severe Acute Malnutrition

Summary: the investigators will perform a randomised controlled trial of the provision of food designed for rehabilitation of malnourished children that is supplemented with n-3 fatty acids compared to usual composition. the investigators want to see whether the provision of such a food normalises the deficiencies in essential fatty acids observed in severely malnourished children faster than standard composition.

randomized controlled trial of n-3 polyunsaturated fatty acid-enriched therapeutic food for severe malnutrition. description of study design: randomized controlled trial study duration: 6 months (trial); 12 months (all trial-related activities) description of intervention: provision of ready to use food (rutf) enriched with flax seed oil, with or without fish oil, compared to conventional-composition rutf. interventional product will be given until nutritional recovery to a maximum of 12 weeks. design: flax-enriched or standard rutf allocation is randomised and double blind. fish oil allocation is randomised within those receiving flax-enriched rutf and is open label. location: kilifi district, coastal kenya.

Eligibility criteria:
inclusion criteria: * children aged 6 months to 5 years old * provision of informed consent * severe malnutrition (one or more of mid-upper arm circumference \<11.5cm, weight for height z score \<-3, or nutritional oedema) * stabilised and eligible to receive rutf according to national guidelines exclusion criteria: * known hiv disease, tuberculosis or other chronic infection\* * known allergy or hypersensitivity to any of the product ingredients * chronic infections such as hiv and tuberculosis and their treatments are likely to cause alterations in lipid metabolism that may confound interpretation of this pilot trial. national guidelines recommend offering provider-initiated testing for hiv for all severely malnourished children, and referral for comprehensive care in the case of a positive test.

Keywords: essential fatty acid seed oil fish oil dietary deficiency
the effects of mirror-based virtual reality systems and recalibration software on upper extremity function in individuals experiencing hemiparesis post-stroke

Conditions: Stroke; Hemiparesis

Summary: the goal of this study is to learn about the benefits of using a virtual reality gaming system that can be adjusted for a person who has upper arm weakness from stroke. the main question it aims to answer is whether strength and movement in the upper arm be improved by use of the gaming system. participants will be asked to complete initial measurements of upper arm function, play a video game for one hour, four times a week for five weeks, and repeat the measurements of upper arm function at the end.


Eligibility criteria:
inclusion criteria: * self-reported diagnosis of stroke * greater than 2 years post-stroke * access to reliable transportation * history of weakness/hemiparesis of one upper limb exclusion criteria: * significant vision impairment or blindness * non-english speaking * history of seizure or seizure disorder * health conditions which would be exacerbated by low-intensity exercise * inability to use arms independently for exercise
national bacterial meningitis study

Conditions: Meningitis; Children, Only; Pneumococcal Conjugate Vaccine; Meningococcal Vaccines; H. Influenzae Vaccine; Neonatal Infection; Antibiotic Treatment; Case Fatality Rate

Summary: bacterial meningitis is a major cause of morbidity and mortality in childhood. antibiotic treatment recommendations are based on epidemiological and susceptibility data. the epidemiology of bacterialméningitis has changed in recent years, mainly owing to widespread use of different conjugate vaccines. the aim of this prospective national survey is to describe epidemiology of bacteria implicated in bacterial meningitis in children.


Eligibility criteria:
inclusion criteria: * clinical signs of meningitis, associated with positive cerebrospinal fluid (csf) culture and/or positive csf antigen testing (escherichia coli k1, n. meningitidis serogroups b, a, c, y and w-135, group b streptococci, hib, or s. pneumoniae), and/or positive csf polymerase chain reaction (pcr), and/or positive blood culture with csf pleocytosis (\> 10 cells/µl). * purpura fulminans exclusion criteria: -
fear of movement, functionality and quality of life in elite athletes with an ankle instability history

Conditions: Ankle Sprains

Summary: ankle sprain is frequently experienced by individuals participating in different sports activities. ankle sprains have been shown to result in a decrease in level of physical activity and persistence of some symptoms for a long time. in this case, it is predicted that ankle sprains may affect the quality of life as well as functionality. also, ankle sprain history may result in increased fear of movement, which may delay return to sports. this study aimed to examine the relationship between foot and ankle functionality, fear of movement and quality of life of elite athletes with a history of ankle sprain.


Eligibility criteria:
inclusion criteria: * no injury to the upper or lower extremities during data collection, * being older than 18 years of age, * individuals who volunteer to participate. exclusion criteria: . having had ankle surgery, * has had an injury to his lower extremity in the last 3 months, * individuals with a history of neurological / neuropsychiatric disease or arthritis will be excluded from the study.

Keywords: quality of life fear of movement functionality ankle sprain
phytoestrogens and breast cancer - effects of phytoestrogens on markers of disease progression and gene expression

Conditions: Breast Cancer; Breast Neoplasms; Breast Cancer Female

Summary: the aim is to investigate if soy isoflavones and lignans affect markers of disease progression and gene expression among breast cancer patients receiving neo-adjuvant treatment in a three arm, double-blinded, randomized placebo-controlled trial (rct) comparing: soy isoflavone supplementation, lignan supplementation, and placebo.


Eligibility criteria:
inclusion criteria: * diagnosed with breast cancer at "brystkirurgisk afdeling" at rigshospitalet and herlev hospitals (within the last 30 days). * advised (and accepted) to receive neo-adjuvant treatment * primary unilateral breast cancer * treatment is expected to be curative * is expected to be able to attend surgery exclusion criteria: * allergic to soy * celiac disease * inflammatory bowel disease * not understanding danish (patient material and questionnaires are in danish) * prior diagnosis of breast cancer * use of dietary supplements containing lignans or isoflavones three months prior to diagnosis

Keywords: phytoestrogens isoflavones lignans gene expression breast cancer
treatment of pediatric mid-shaft clavicle fractures: a prospective, observational study

Conditions: Clavicle Fracture; Adolescent

Summary: clavicle fractures in children are common. typical treatment includes nonoperative treatment with a sling. operative treatment is usually limited to open, unstable, fractures with either epidermal risks or neurovascular compromise. orthopaedic literature has many studies that report the need for additional research for this prevalent fracture. this is an observational study evaluating the functional and patient reported outcomes of displaced clavicle fractures in adolescents. the results from this study will help the orthopedist understand the expected outcomes for a given pediatric patient with a clavicle fracture.


Eligibility criteria:
inclusion criteria: * 11-17 years old with fractures of the middle third of the clavicle * displaced 100% the width of the clavicle or shortened 1 centimeter * operative and non-operative treated clavicles will be eligible for enrollment exclusion criteria: * open clavicle fractures * ipsilateral shoulder injuries * fractures involving the lateral ligaments or the sternoclavicular joint * bilateral clavicle fractures * pathologic fractures * refractures * fractures with neurovascular compromise * displaced fractures with impending skin compromise * if there has been more than 21 days between injury and enrollment * patients with cognitive disabilities that inhibit the completion of the questionnaires
intravitreal topotecan in the repair of rhegmatogenous retinal detachment with proliferative vitreoretinopathy

Conditions: Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment

Summary: intravitreal topotecan has anti-inflammatory, anti-proliferative and anti-fibrotic activity that we hypothesize may exhibit high efficacy for the treatment of proliferative vitreoretinopathy (pvr) in patients with rhegmatogenous retinal detachment (rrd). a high efficacy for intravitreal topotecan has been exhibited in cell cultures of pvr. at the same time, intravitreal topotecan has been routinely used in the treatment of vitreous seeds from retinoblastoma. at doses of 5-30 micrograms per injection, no adverse events have been reported with the use of intravitreal topotecan. therefore, the current prospective matched phase ii trial aims to investigate the efficacy and safety of intravitreal topotecan for severe pvr in patients with rrd.


Eligibility criteria:
to be enrolled, patients need to meet the following inclusion criteria: 1. patients aged 18 years and older 2. patients who undergo ppv and/or sb for recurrent rrd due to pvr 3. patients with rrd and pvr grade c or d 4. patients who have failed standard of care surgery for rrd in the same eye previously. in order to satisfy this inclusion criterion, patients need to have previously received at least one vitreoretinal surgery for rrd, including pneumatic retinopexy, pars plana vitrectomy and/or scleral buckle, and to have clinical documentation supporting re-detachment of the retina after one or more vitreoretinal surgeries for rrd in the same eye. this cohort of patients is expected to have an extremely guarded visual prognosis and visual potential. 5. patients who are voluntarily able and willing to participate patients undergoing combined phacoemulsification and ppv and/or sb will also be included. any surgical technique will be considered, including relaxing retinotomy or retinectomy during ppv. the following subject exclusion criteria will be considered: 1. patients with a history of tractional or exudative retinal detachment 2. patients with severe non-proliferative or proliferative diabetic retinopathy 3. patients with other planned ocular surgery following ppv 4. patients with primary rrd 5. female patients of childbearing age (i.e. less than 50 years old). 6. patients with pre-existing bone marrow suppression or cytopenias 7. patients with pre-existing interstitial lung disease (ild) any other medications or treatments, including rescue therapy, will be permitted before and/or during the trial.
virtual reality in reducing acute orthopedic pain

Conditions: Fractures

Summary: the primary aim of this research is to show that a virtual reality (vr) service line is feasible and can sustain itself with the ability to take care of patients. additionally, the investigators aim to learn about the limitations of a service line and provide a pathway for future improvements in building a vr service line that is optimally aligned with the user's needs. secondary aims are to evaluate the clinical aspects of the patient's outcomes including length of stay, morphine equivalents in pain medicine required during the hospital stay, and user experiences.


Eligibility criteria:
inclusion criteria: 1. hospitalized with an orthopedic fracture 2. able to participate fully in all aspects of the study 3. able to understand and sign informed consent 4. individuals with unaided vision or those who can correct their vision using contact lenses exclusion criteria: 5. non-english speaking 6. self-reported history of acute and/or chronic severe motion sickness 7. the presence of a facial/head deformity that will prohibit the wearing of a vr head mounted display. 8. legally blind or deaf 9. have had a seizure within the past 1 year 10. have current (within the past 30 days) clinically significant acute or chronic progressive or unstable/uncontrolled neurologic disorder 11. have a known history of any condition or factor judged by the investigator to preclude participation in the study or which might hinder adherence

Keywords: pain control orthopedic fracture hospital
a multicenter, double-blind, controlled study to evaluate ampligen

Conditions: HIV Infections

Summary: to evaluate ampligen at two dosage levels given twice weekly in combination with zidovudine (azt) versus azt alone in individuals with hiv-related immune dysfunction defined as t4 count between 100 and 300 cells/mm3.


Eligibility criteria:
inclusion criteria patients must have: * hiv-1 seropositivity. * absolute number of t4 cells 100-300 cells/mm3. * given informed consent. * zidovudine (azt) therapy for 6 months prior to study entry. * at least one of the listed hiv-related clinical symptoms or opportunistic infections: * weight loss \> 10 percent, unexplained diarrhea, unexplained intermittent fever, oral candidiasis \> 1 month, decreased karnofsky, oral hairy leukoplakia, chronic fatigue. exclusion criteria co-existing condition: patients with the following conditions or symptoms are excluded: * evidence of aids. * intercurrent acute medical disorder. concurrent medication: excluded: * chemotherapy for kaposi's sarcoma (ks). * aspirin. * non-steroidal anti-inflammatory drugs. patients with the following are excluded: * inability to return for treatment and evaluation for 12 months. * intercurrent acute medical disorder. * evidence of aids. * receiving chemotherapy for kaposi's sarcoma (ks). * unwilling or unable to give informed consent. required: * zidovudine (azt). required at least 6 months prior to study entry: * zidovudine (azt). active drug abuse.

Keywords: acquired immunodeficiency syndrome ampligen aids-related complex zidovudine
the impact of root end filling material type and the application of bone graft on healing of periapical tissues after endodontic microsurgery (a clinical randomized controlled trial)

Conditions: Periapical Diseases; Periapical Cyst

Summary: the goal of this triple blinded randomized clinical trial is to evaluate the effect of combining different bioactive root end filling materials with composite bone graft (xenogeneic mixed with autogenous bone fragments) on the healing process of periapical tissues after endodontic micro-surgery procedure on patients with small to moderate sized lesions. the main questions it aims to answer are: will the use of totalfill in endodontic surgeries show comparable results to the gold standard mta? will the addition of composite bone graft (xenogenic and autogenous) affect the healing of small to moderate sized lesions? is there any interaction between composite bone graft and different bioactive root-end filling materials? participants were allocated to 4 different groups according to the root-end filling material used with or without bone graft. reseachers compared between mta only group, totalfill only group, mta with bone group, and totalfill with bone group to evaluate healing of the periapical lesion using cbct after 12 months follow up period.


Eligibility criteria:
inclusion criteria: all patients must be medically free from any systemic disease that can affect bone healing. age range of the patient should be between 20 - 45 years old. all patients must have good oral hygiene. the size of the radiolucent area is of small-moderate size (up to 3 cm in highest diameter at any axis in cbct), related to a single rooted maxillary tooth. periradicular disease in a root-filled tooth where orthograde root canal treatment options has failed, exclusion criteria: patient with systemic disease that may affect bone healing. patients above 45 years or patients below 20 years. patients with very poor oral hygiene. teeth presenting with apico-marginal defects or teeth with periodontal disease (periodontal pockets and/or mobility). surgery after previous endodontic surgery (re-surgery cases), root resections and amputations, cases presenting with root fractures. patients with history of allergies to any of the medications to be used during or after the surgery.

Keywords: apicoectomy bone graft endodontic surgery mta totalfill apical lesions