enteral naloxone versus a traditional bowel regimen for the prevention of opioid induced constipation in trauma patients

Conditions: Constipation; Analgesia

Summary: the purpose of this study is to determine if enteral naloxone is more effective than a traditional bowel regimen in the prevention and treatment of constipation and impaired gastric motility in critically ill trauma patients.

impaired gastric motility and constipation are common issues among patients in the intensive care setting. contributing factors include trauma, multiple surgical procedures, lack of ambulation, and the use of opiate analgesics to control pain. common treatments for altered gastric motility and constipation include administration of pro-motility agents, stool softeners and bowel stimulants. enteral feeding is considered the safest and most effective way to provide nutrition to critically ill patients. nutrition can be delayed and/or held when impaired gastric motility and constipation are present. studies suggest that delays in the administration of nutrition can lead to prolonged ventilator time and increased length of stay in the intensive care setting as well as an increase in mortality. naloxone, a competitive opioid antagonist, is most commonly administered systemically to counteract the central and peripheral effects of opioids. when administered enterally naloxone has also been found to increase gastric emptying. studies in patients receiving enteral feeds with multiple risk factors for altered gastric motility and constipation suggest that administration of enteral naloxone can reduce the incidence and extent of altered gastric motility and aid in defecation while not totally reversing the systemic effects of the opiate being administered. due to these findings, it appears that enterally administered naloxone would provide a significant advantage over traditional gastrointestinal stimulants in preventing constipation in critically ill patients receiving continuous administration of opiate analgesics. in addition, the use of an enterally administered opiate antagonist may also alleviate the need for routine administration of pro-kinetic agents in order to promote adequate gastrointestinal motility and toleration of enterally administered nutrition. as a result, the comparison of enteral naloxone plus a stool softener versus a traditional bowel regimen containing a stimulant and stool softener will aid in assessing the effectiveness of opiate reversal locally in the gastrointestinal tract in prevention of decreased gastric motility and constipation.

Eligibility criteria:
inclusion criteria: * males and non-pregnant females \> 18 years of age and \< 65 years of age * msicu admission to the trauma service at the general hospital * scheduled for continuous infusion/administration of opiate analgesics for at least 24 hours * access for enteral administration of medications and tube feeds * initiation of tube feeds exclusion criteria: * npo * pregnancy * \ 65 years of age * pancreatitis * ileus * large bowel obstruction present on plain x-ray or ct scan * recent intestinal anastomosis (within 2 weeks) * section of large bowel removed (within 2 weeks) * contraindications to metaclopramide (reglan) such as parkinson's disease, tardive dyskinesia, etc. * traumatic brain injury with a glasgow coma score of at least 8 * use of pharmacologic paralytics or neuromuscular blockade (nmb) * non-english speaking patients

Keywords: enteral nutrition constipation gastrointestinal motility naloxone docusate bowel stimulant stool softener