Kornimate/medical-research-clean huggingface dataset:
cavernous sinus dissection and bleeding in meningiomas

Conditions: Meningiomas of the Middle Cranial Fossa

Summary: the blood loss will be compared in middle fossa meningiomas which will receive pealing of the outer layer of the lateral wall of the cavernous sinus and those which will not revive pealing before the dura is opened

cases with middle fossa meningiomas will be randomised to one of two surgical techniques. the first technique will involve pealing of the outer layer of the lateral wall of the cavernous sinus before the dura is opened and the tumour attacked, and the second group of cases will be operated by a standard technique, where the tumour will be directly attacked with out pealing of the outer layer of the lateral wall of the cavernous sinus. blood loss will be monitored in each case by calculating the amount of blood in the suction container and subtracting it from the amount of fluids used for irrigation during surgery. the number of cotton patties and dressings will be also counted with each case as well as the number of gauzes used. the pre-operative complete blood picture will be documented particularly the haemoglobin , hematocrits and others. the same lab data will be also monitored after surgery. the amount of blood transfusion required will also be calculated in each case.

Eligibility criteria:
inclusion criteria: * meningiomas of the middle cranial fossa exclusion criteria: * meningiomas outside the middle cranial fossa
fractures and bone disease in living kidney donors

Conditions: Renal Transplant Donor of Left Kidney; Renal Transplant Donor of Right Kidney

Summary: this research study is being done to measure bone health in living kidney donors and compare them to non-kidney donors to learn if living kidney donors have a higher risk of bone fractures (breaks) after kidney donation. certain chemicals in the body that help maintain bone health were shown to have changed after kidney donation in living donors, whether or not these changes lead to a decrease in bone quality and increase the risk of fractures is not known. the purpose of this study is to compare the bone health of living kidney donors, with the bone health of non-kidney donors. this information will be helpful in informing future kidney donors of the risks of donation and in creating treatments to help prevent these complications.

this is an observational study that consists of two aims: aim 1 is a survey sent to 3000 prior living kidney donors and 3000 matched controls. the survey contains questions about history of bone fractures and general bone health. prior living kidney donors will be identified and surveyed from three minnesota centers: mayo clinic, rochester; hennepin county medical center (hcmc); and the university of minnesota (umn). aim 2 of this study includes an assessment of bone structure and bone turnover markers in a subset of donors and matched controls. 200 prior living kidney donors and 200 matched controls will be invited to mayo clinic rochester's crtu for an assessment of bone health. each subject will undergo lateral dxa with vfa assessment, bone density assessment of each hip, radius and spine by dxa scan, bone structure assessment by hrpqct of the distal radius and tibia, finite element assessment(µfea), skin ages measurement, and blood collection to measure markers of bone formation and resorption.

Eligibility criteria:
inclusion criteria: aim 1: survey (donors): * donated a kidney at one of the three participating sites. * 10 or more years have passed since donation. * age ≥ 50 at time of study enrollment. aim 1: survey (controls): * subjects in the rep population. * medical records available for the five years preceding age at matching (age at donation). * matching will be based on: age, year of donation, sex, race/ethnicity, body mass index, comorbidity and selected risk factors (smoking, education level) status at year of donation aim 2: skeletal health assessment (donors and controls): * subjects who have completed the survey * willing to come in for the in-person assessment exclusion criteria: aim 1: survey (donors): * deceased * not willing to return the survey. aim 1: survey (controls): * deceased * not willing to return the survey * history of the following conditions: * diabetes mellitus, liver disease, kidney disease, nephrolithiasis, malabsorption syndrome, past history of non-traumatic fractures. aim 2: skeletal health assessment (donors and controls): * subjects who did not participate in the survey * subjects not willing to come for the in-person evaluation. * women of childbearing potential.
psychological state of students of health sciences during covid-19

Conditions: Stress, Psychological; Anxiety; Depression; Covid19

Summary: university students report high levels of stress, anxiety and depression every year, which, according to some research, responsible for university administration and popular media, constitutes a global crisis of mental health of students at these levels. exposure to academic stress directly compromises students' motivation and attitudes towards learning. high levels of perceived distress in the face of inadequate resources to deal with the situation leaves people at risk of developing major psychiatric problems, especially when this distress is prolonged or severe.

main goal:study the impact of socio-demographic, personal and health factors that determine the performance / perception of pandemic stress) in students of bachelor's degrees in health sciences. secondary objectives: * analyze the relationship between socio-demographic and personal characteristics and the perception of stress related to the covid-19 pandemic. * identify the relationship between the perception of stress related to the covid-19 pandemic and the role of gender / physical activity and the academic performance of undergraduate students in health sciences. methodology all variables will be obtained only once by means of a survey through google form. the questionnaire will be disseminated to all students of the degrees, by institutional email, through direct contact with the delegates of each course. after the first two weeks, a reminder will be made following the same routes. there will be no follow-up.

Eligibility criteria:
inclusion criteria: * students of the degree of nursing, occupational therapy and physiotherapy belonging to the faculty of health sciences exclusion criteria: * not belonging to any degree in health sciences of the faculty of health sciences

Keywords: university students physical activity gender stereotype
implant stability changes using underdrilling versus osseodensification protocols for posterior dental implants

Conditions: Dental Implant Stability

Summary: this clinical trial aims to compare two drilling protocols underdrilling and osseodensification for placing dental implants in patients with low bone density. the purpose is to compare which technique provides better primary and secondary implant stability in the posterior regions of the jaw with low bone density. the hypothesis is that there is no significant difference in implant stability between the two protocols.

achieving sufficient primary stability becomes difficult in areas with low bone density. one technique commonly used is underdrilling protocol.with the underdrilling technique, the final osteotomy is smaller than the diameter of the implant to be placed.a relatively new osseodensification protocol, introduced by huwais in 2013, employs specially designed bur that smoothly compact the bone as they expand an osteotomy. this may prove to be particularly helpful in cases with low bone quality.this clinical trial aims to compare the implant stability using these drilling protocols

Eligibility criteria:
inclusion criteria: 1. patient partially edentulous ridge after extraction of more than 6 months and with low bone density. 2. systemically healthy patients ≥18 years of age. exclusion criteria: 1. smokers. 2. pregnant or lactating females. 3. uncontrolled systemic disease like diabetes, hypertension, hormonal therapy and hematologic diseases. 4. history of maxillary sinus pathology.

Keywords: secondary implant stability
body perception and complex regional pain syndrome

Conditions: Complex Regional Pain Syndromes

Summary: in crps, perturbation of body image and pseudo-neglect syndrome of the body part affected are frequently found. pain and sensory perturbation seems to modify the way patients perceived their body part affected. does a local body image perturbation can affect the balanced of the global self-awareness?

with the investigation of spontaneous sensations (sps) according to the protocol of michael and al (2011) the investigators study how patients can listen to their internal sensations located in other body part than the painful member in order to construct a representation of the body and maintain it in active consciousness. a group of controls will be included to understand if there is a global modification in the perception of sps witch may be linked to the pathology.

Eligibility criteria:
inclusion criteria: * for patients: • a diagnosis of crps of the lower limb according to the budapest criteria (men or women) for patients and control group * age ≥ 18 years exclusion criteria: for patients and control group * neurological disease with cerebral repercussion or not stabilized serious physical illness; * psychotropic medication * disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal); * for patients: * presence of an other pain disorder

Keywords: complex regional pain syndromes pain spontaneous sensations interoception
expired propofol in low back surgery

Conditions: Anesthesia

Summary: edmon (bbraun, germany) is a portable, commercially available device for measurement of propofol in exhaled air. the study will aim at evaluating the sensitivity and specificity of such exhaled propofol values compared with plasma propofol and measures of anaesthetic and antinociceptive effect.

elective low-back surgery patients will be induced for general intubation anesthesia with propofol and remifentanil. after induction a 20 min period of stable propofol infusion only will be established before start of surgery. the patients will be monitored for exhaled propofol, plasma propofol (blood samples), continous frontal eeg, bispectral index (bis), skin conductance, estimated (computer based) concentrations of plasma and effect site propofol, and skin conductance. after start of surgery (with ongoing propofol and restart of remifentanil tci) the monitoring will continue in order to explore these relationships further.

Eligibility criteria:
inclusion criteria: * elective patients scheduled for low-back surgery * bmi between 20 -32 kg/m2 * asa i-ii * written informed concent exclusion criteria: * contraindication to propofol tci * use of psychopharmaco or neurologic disease * pregnancy or breast feeding
turkish translation of the emphasis-10 questionnaire

Conditions: Pulmonary Hypertension

Summary: pulmonary hypertension (ph) is a hemodynamic and physiopathological condition that is defined as an increase in mean pulmonary artery pressure ≥25 mmhg when measured at rest. ph often progresses to heart failure and premature deaths. ph is a progressive disease that has many causes, which can affect people of all ages, is characterized by shortness of breath, reduced exercise tolerance, psychological distress and tiredness and reduced quality of life. surveys of sf-36, 'nottingham health profiles' and 'minnesota life with heart failure' surveys are routinely performed in ph clinically. however, none of the questionnaires are specific to pulmonary hypertension, so they are incomplete in determining the condition of the disease and the patients. there is no turkish questionnaire for patients with pulmonary hypertension and other surveys used are inadequate in determining the condition of the patient and the patient since they are not specific to the disease. the aim is to provide a turkish questionnaire that is specific to pulmonary hypertension in the literature.


Eligibility criteria:
inclusion criteria: * have been diagnosed with pulmonary hypertension * following at least 6 months of pulmonary hypertension policlinic * native turkish * people age 18 years or older exclusion criteria: * those with cognitive impairment * those who have difficulty understanding or speaking turkish

Keywords: quality of life
the exploratory clinical trials for the feasibility, primary safety and efficacy of foldable capsular vitreous body

Conditions: Retinal Detachment

Summary: the purpose of this study is to determine the feasibility, primary safety and efficacy of foldable capsular vitreous body (fcvb) in the treatment of retinal detachment.

pars plana vitrectomy (ppv) has been one of the most important ophthalmic surgeries for treating a number of blinding diseases by removing and replacing the diseased vitreous body. current clinic vitreous substitute cannot mimic the natural vitreous which is unable to regenerate after surgery. we have devised a novel foldable capsular vitreous body (fcvb) consisting of a vitreous-like capsule with a tube-valve system, and demonstrated it could finely mimic the morphology and restore main physiological function of the natural vitreous body in our previous study.

Eligibility criteria:
inclusion criteria: 1. refractive error less than ±3d 2. visual acuity worse than finger count 3. ocular perforating injuries, traumatic retinal detachment, giant retinal tear with pvr, serious than grade d pvr, ocular axial length is 16 to 25mm 4. signed the informed consent form exclusion criteria: 1. serious heart, lung, liver and kidney dysfunction 2. serious eye inflammation 3. silicone oil filled eyes 4. the contralateral eye is non-functional 5. patients with diseases that the researchers consider not suitable participated in this clinical trial

Keywords: retinal detachment, vitreous body substitute
esp block, cnp and qol after vats

Conditions: Postoperative Pain; Video-assisted Thoracoscopic Surgery

Summary: the erector spinae plane block (espb) is an adequate alternative for pain management after video-assisted thoracoscopy surgery (vats). the incidence of postoperative chronic neuropathic pain (cnp) and the quality of life (qol) in patients with espb after vats remain unknown. we hypothesised that patients with espb would have a low incidence of acute and cnp and would report a good qol up to three months after vats.

we, therefore, performed this prospective observational study. the a priori primary outcome was incidence of cnp three months postoperatively (pop) in patients undergoing vats surgery with espb as the regional anaesthesia technique. the secondary outcome was to describe pain control at pacu, 12 and 24 hours pop and qol reported up to three months after surgery. we hypothesised that patients with espb would have a low incidence of acute and cnp and report a good qol.

Eligibility criteria:
inclusion criteria: * patients who underwent vats and required at least one day of hospital stay after surgery exclusion criteria: * patients with mental or physical limitation to answer the questionnaires. * patients who required mechanical ventilation. * patients who required surgery conversion to thoracotomy. * patients who declined consent.

Keywords: regional anesthesia postoperative pain video-assisted thoracoscopic surgery erector spinae plane block neuropathic pain quality of life
the correlation of pd-l1 expression in non-small lung cancer tissue and peripheral blood t cell and serum.

Conditions: NSCLC

Summary: the detection of tissue pd-l1 immunohistochemistry in non-small cell lung cancer (nsclc) has an important role in guiding for the treatment of immune detection point. at the same time,tissue detection is time-consuming and laborious, liquid biopsy can reflect the information of tumor tissue,pd-l1 expression in serum and peripheral blood t cell are expected to be simple, rapid, non-invasive means of detection. the project is planned to explore the correlation of pd-l1 expression in non-small lung cancer tissue and peripheral blood t cell and serum..the investigators have designed to detected the expression levels of pd-l1 protein in cancer tissue and detected the expression levels of pd-l1 in peripheral blood t cell and serum.by using variance analysis of repeated measures design information. thus exploring the correlation of pd-l1 expression in non-small lung cancer tissue and peripheral blood t cell and serum,guiding clinical practice of immunotherapy.


Eligibility criteria:
inclusion criteria: 1. pathological histology and/or cytology confirmed non-small lung cancer; 2. voluntarily enrolled to participate in,better compliance, cooperate with experimental observations, and sign informed consent. exclusion criteria: 1. vital organs (e.g., heart, liver, kidney) have serious dysfunction; 2. patients with a history of autoimmune disease; 3. patients with participating in other clinical trials at the same time; 4. other cases that researchers believe that patients should not participate in the present trial.
effect of educatıon gıven to patıents wıth ureteral stent (dj) insertıon on postoperatıve symptom management and qualıty of lıfe

Conditions: Ureteral Calculi

Summary: the data of the randomized controlled experimental study were collected at the urology clinics of atatürk university health practice and research hospital between april and november 2022. the study sample consisted of 162 patients (82 in the training group, 80 in the control group) who were selected by simple random sampling method and met the inclusion criteria for the study.

ureteral stents have been widely used in many urological procedures since their use was published by zimskind in 1967 and finley's use of the modern double j (dj) stent in 1978. ureterorenoscopy (urs) is a popular method used frequently in the diagnosis and treatment of ureteral diseases today. apart from being performed for diagnostic purposes, urs is most commonly used to treat ureteral stones. the vast majority of ureteral stones are treated endoscopically. a double-j (dj) stent is often placed after ureterorenoscopy. the purpose of the stent is to prevent obstruction, renal colic, and deterioration of renal function. the fact that the dj stent will remain in the patient for a certain period of time (approximately 3-4 weeks) causes anxiety in the patient. however, urinary system symptoms that impair the quality of life are observed in approximately 80% of patients who have a dj stent. these symptoms include frequent urination (50-60%), urgency (57-60%), pain during urination (40%), incomplete voiding (76%), flank pain (19-32%), suprapubic pain (30%), incontinence and hematuria (25%). in addition, 32% of patients with dj stents develop sexual dysfunction. 2,3,4 patients who have dj stents inserted after ureteroscopy surgery need more information, support, explanation and help to cope with the effects of these symptoms in the clinic and at home. 5 in this context, it is important to provide individualized and comprehensive education that includes the home care process before and after urs. it has been determined in the literature that education given before surgical intervention reduces anxiety, pain level, complication rate and depression rate in the postoperative period and increases patient satisfaction. 6,7,8 however, it is reported that individuals should be discharged with sufficient theory and practice to meet their post-discharge care needs. although all healthcare personnel are responsible for the discharge education of individuals and their relatives, the most important responsibility belongs to nurses.

Eligibility criteria:
inclusion criteria: * being between the ages of 18-65 * volunteering to participate in the study * having urs surgery for the first time due to stones and temporary dj stent placement exclusion criteria: * having urs surgery for reasons other than stones * having a permanent stent * having major hearing and vision impairment * using antidepressants or anxiolytics

Keywords: ureteral stent (dj), symptom management, quality of life
pathogenesis of hematologic malignancies

Conditions: Acute Leukemia; Lymphoproliferative Disorders; Myeloproliferative Disorders; Myelodysplastic Syndromes

Summary: the cause of blood and bone marrow cancers is poorly understood; however, most research focuses on how cancer cells grow and develop. because the causes of these cancers are unknown, current treatments may be unnecessarily harsh and often do not provide a cure. identifying the causes of blood cancers would allow for the development of treatments that are more likely to provide a cure. to find the causes of blood and bone marrow cancers, we will look for specific cancer cell abnormalities that are responsible for cancer cell growth. we will then look to see if drugs that can reverse these abnormalities can kill cancer cells.


Eligibility criteria:
inclusion criteria: * suspected or confirmed diagnosis of al, lpd, mds, or mpd * male or female of all ages * willing and able to sign informed consent * willing guardian consent for participants under 18 years of age exclusion criteria: * no suspected or confirmed diagnosis of acute leukemias (al), lymphoproliferative disorders (lpd), myelodysplastic syndromes (mds), or myeloproliferative diseases (mpd)
a study of arry-334543 in patients with advanced cancer

Conditions: Advanced Cancer

Summary: this is a phase 1 study during which patients with advanced solid tumors will receive a new formulation of investigational study drug arry-334543. patients will receive increasing doses of study drug in order to achieve the highest dose possible that will not cause unacceptable side effects. the patients will be followed to see what side effects and effectiveness the study drug has, if any, in treating the cancer. in addition, the effect of food on the new formulation will be evaluated. approximately 24 patients from canada will be enrolled in this study (active, not recruiting).


Eligibility criteria:
key inclusion criteria: * histological or cytological evidence of malignancy. * patients with advanced solid tumors who are no longer candidates for standard therapy, have no standard therapy available, or choose not to pursue standard therapy. * cardiac ejection fraction ≥ 50% by echocardiogram (echo) or multiple gated acquisition (muga). * eastern cooperative oncology group (ecog) performance status (ps) of 0, 1 or 2. * additional criteria exist. key exclusion criteria: * uncontrolled brain metastases (if a patient has brain metastases and is on steroids, the steroid dose must be stable for at least 30 days). * use of an investigational medication or device within 30 days prior to first dose of study drug. * major surgery within 30 days prior to first dose of study drug. * radiotherapy or chemotherapy within 28 days prior to first dose of study drug (not including palliative radiotherapy at focal sites). * active, uncontrolled infection requiring systemic antibiotic therapy or other serious underlying medical condition which would impair the ability of the patient to receive protocol treatment. * pregnancy or lactation. * known positive serology for the human immunodeficiency virus (hiv), 'active' hepatitis b and/or hepatitis c. * additional criteria exist.