Kornimate/medical-research-clean huggingface dataset:
effects of task-oriented training on functional mobility and fatigue in patients with multiple sclerosis

Conditions: Multiple Sclerosis, Relapsing-Remitting

Summary: multiple sclerosis (ms) is inflammatory, demyelinating and autoimmune disease of the central nervous system. it is usually seen with relapses and genetic and environmental factors play a role in the etiology. neurological symptoms seen in ms restrict the patient's daily activity and social role participation. mobility problems and fatigue are the most important reasons of role limitations and decreased quality of life. the importance of exercise training in disease management has been emphasized in recent years. however, few studies have investigated the effects of task-oriented trainings on symptoms of the disease. the aim of this sudy is to investigate the effects of task-oriented training additional to combined exercise training on functional capacity, mobility, balance, fatigue and quality of life in patients with ms.


Eligibility criteria:
inclusion criteria: * multiple sclerosis diagnosis * expanded disability status scale \> 5,5 * no cognitive problems * no relapses in the last 3 months * no other neurological or chronic disease exclusion criteria: * relapse during the intervention * exercise intolerance

Keywords: task-oriented training exercise training mobility balance fatigue quality of life
reduced-dose versus standard dose radiotherapy for nasopharyngeal carcinomain

Conditions: Nasopharyngeal Carcinoma

Summary: to study the 2-year pfs (progression-free survival) of patients with stage ii-iii nasopharyngeal carcinoma treated with induction chemotherapy followed by two different doses of intensity modulated radiation therapy plus concurrent cisplatin chemotherapy

to explore the 2 year pfs of patients with stageii-iii nasopharyngeal carcinoma treated with induction chemotherapy followed by reduced-dose radiotherapy and cisplatin versus standard dose radiotherapy plus cisplatin concurrent chemotherapy. the enrolled patients will receive 2 cycles of cisplatin-based induction chemotherapy, if radiographic cr/pr and ebv dna=0 after induction chemotherapy, the patients will be randomised assigned to received 60 gy imrt combined with 2 cycles of cisplatin concurrent chemotherapy or 70gy imrt combined with 3 cycles of cisplatin concurrent chemotherapy.

Eligibility criteria:
inclusion criteria: 1. patients newly diagnosed with histologically confirmed non-keratinizing npc (who type ii or iii). 2. stage ii-iii（8thajcc/uicc staging system) 3. aged 18-70 years 4. ecog = 0-1 5. hgb≥90 g/l，wbc≥4×109 /l，plt≥100×109 /l 6. alt,ast\<1.5 x uln；tbil\<1.5×uln 7. ccr≥60ml/min or cr\<1.5×uln 8. cr/pr and ebvdna undetectable after induction chemotherapy 9. signed informed consent exclusion criteria: 1. who type keratinizing squamous cell carcinoma or basaloid squamous cell carcinoma 2. age \ 70years 3. treatment with palliative intent 4. prior malignancy except adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer 5. pregnancy or lactation 6. history of previous radiotherapy (except for non-melanomatous skin cancers outside intended rt treatment volume) 7. prior chemotherapy or surgery (except diagnostic) to primary tumor or nodes 8. any severe intercurrent disease, which may bring unacceptable risk or affect the compliance of the trial, for example, unstable cardiac disease requiring treatment, renal disease, chronic hepatitis, diabetes with poor control (fasting plasma glucose \>1.5×uln), and emotional disturbance

Keywords: nasopharyngeal carcinoma radiotherapy induction chemotherapy
manual therapy and exercise versus home exercises in the management of patients status post ankle sprain

Conditions: Ankle Sprain

Summary: a recent study has demonstrated that a physical therapist directed exercise program did not result in greater reductions in disability and pain when compared to a home exercise program. however, no manual therapy procedures were incorporated into the physical therapy treatment program despite recent evidence suggesting that thrust and non-thrust manual therapy techniques may be beneficial in reducing disability, pain and improving gait. therefore, the purpose of this study is to compare the effectiveness of a physical therapy management approach consisting of manual therapy and exercise to a home program of exercise only. the investigators hypothesize that the group receiving manual therapy and exercise will have better outcomes.


Eligibility criteria:
inclusion/exclusion criteria: * a combination of physical examination and self-report measures will be used to assess the patient's potential eligibility according to each inclusion/exclusion criterion. * the following inclusion criteria will be used to determine eligibility for this study: * primary complaint of ankle pain, status post inversion ankle sprain. * the investigators decided to include patients with both acute and chronic ankle sprains since our previous work has shown that patients from both stage have exhibited positive benefits with manual therapy.66 * age between 16-60 years old * nprs score \> 3 points (average score) over past 24 hrs. * does not meet criteria for needing radiographs per the ottawa ankle rules * the following exclusion criteria will be used to determine ineligibility for this study: * red flags noted in the patient's medical screening questionnaire (i.e. tumor, fracture, ra, osteoporosis, prolonged history of steroid use, severe vascular disease, etc.) * prior surgery to the distal tibia, fibula, ankle joint, or rearfoot region (proximal to the base of the metatarsals). * grade iii ankle sprain (as defined by the west point ankle sprain grading system and/or tenderness along the anterior medial malleolus as described by,51 fracture, or other absolute contraindications to manual therapy. * insufficient english language skills to complete all questionnaires * inability to comply with treatment and follow-up schedule

Keywords: ankle sprain manual therapy exercise physical therapy patients who have sustained an inversion ankle sprain
esketamine combined with pregabalin on acute postoperative pain in patients undergoing resection of spinal neoplasms.

Conditions: Esketamine; Pregabalin; Acute Postoperative Pain; Neurosurgical Procedures; Perioperative Complication; Spinal Cord Neoplasms

Summary: postsurgical pain is now known to be one of the most common and difficult-to-treat complications of surgery. severe postoperative pain can significantly impair patients' quality of life, social functioning and contribute to excessive health care expenditures. it is worth noting that acute postoperative pain may play a vital role in central sensitization and up-regulation of pain receptors, even factors implicated in the development of cpsp. according to previous studies, the incidence of postoperative pain among patients undergoing spinal surgery was nearly 80%. at the same time, perioperative pain management of patients undergoing spinal surgery has not been clearly. for the past few years, pregabalin and esketamine are becoming important roles in perioperative pain management, lots of studies have shown that these two analgesics might relieve postoperative pain. the aim of this study was to evaluate the acute analgesic effects of esketamine and pregabalin in combination after spinal cord neoplasms resection, so as to find a better way to help the patients undergoing spinal surgery keep away from the acute perioperative pain.


Eligibility criteria:
inclusion criteria: * patient undergoing elective spinal cord neoplasms resection; * ages between 18 and 65 years old; * american society of anaesthesiology (asa) status i-iii; * signed informed consent. exclusion criteria: * previous adverse reaction to ketamine, s-ketamine or pregabalin; * patients with a diagnosed history of severe chronic pain; * patients with long-term analgesic treatment(gabapentin/opioids/ketamine); * patients with aphasia or inability to cooperate with the pain assessments; * known sever insufficiency of vitals(such as heart failure/renal dysfunction/hepatic failure); * patients with a diagnosed history of psychiatric disorder; * patients treated with gabapentin/pregabalin in the last three months; * drug abuse; * body mass index (bmi) \> 35 kg/m2 ; * pregnancy or lactation.
predictors of left ventricular systolic function recovery after transcatheter aortic valve replacement

Conditions: Left Ventricular Systolic Function

Summary: investigate the preprocedural predictors of left ventricular systolic function recovery after tavr

calcific aortic stenosis (as) is the most common valve disease in the western world requiring intervention,although surgical aortic valve replacement (savr) was considered as the first therapeutic method, approximately one-third of as patients cannot undergo savr due to its' high risk or contraindication. since transcatheter aortic valve replacement (tavr)was performed for the first time in 2002,tavr has emerged as a growing prevalent treatment on severe symptomatic as with the procedure initially performed on the inoperable patients with intermediate and high risks. recently, the food and drug administration had approved it on low-risk symptomatic subjects. as has to be considered a disease of the left ventricle (lv) rather than purely affecting the aortic valve, approximately one-third of patients with severe symptomatic as have lv systolic dysfunction . recovery of lv ejection fraction (lvef) is associated with improvements in clinical outcomes after tavr as shown by a lot of studies. the placement of aortic transcatheter valves (partner) trial demonstrated that recovery of lv function in patients with severe symptomatic as and lv systolic dysfunction who underwent tavr, occurs in 40% to 50% of patients . higher trans-aortic mean pressure gradient , less lv hypertrophy, less lv fibrosis and absence of af are predictors of recovery of lv function after tavr . however, there is still a scanty data about the predictors of lv function recovery after tavr.

Eligibility criteria:
inclusion criteria: * patients with symptomatic severe aortic stenosis eligible for tavr with lv systolic function less than 50%. exclusion criteria: * severe rheumatic or degenerative mitral regurgitation. * previous valve replacement. * previous myocardial infarction. * previous coronary artery by bass graft (cabg)surgery. * post tavr significant paravalvular leakage
baseline acl injury risk screening and normative data

Conditions: ACL Injury; Anterior Cruciate Ligament Injuries; Musculoskeletal Injury

Summary: this is a prospective, observational cohort study aimed at establishing a database of normative biomechanics for healthy athletes and surveying these athletes for one year following baseline testing for the occurrence of new musculoskeletal injuries, with a particular emphasis on acl injuries.

this study is a prospective, observational cohort study aimed at establishing a database of normative biomechanics data for healthy athletes. the primary focus is on quantifying muscle strength, movement patterns, and biomechanics in relation to the risk of musculoskeletal injuries, particularly acl injuries. the study will also explore the relationship between these biomechanical factors and the occurrence of new injuries over a one-year follow-up period. the research will involve a large sample size of athletes within the sanford health service area, including those participating in organized sports at middle schools, high schools, and universities. advanced marker less three-dimensional motion capture technology will be employed to gather high-fidelity biomechanical data. this will allow for the development of sophisticated algorithms to assess individual injury risk and facilitate targeted interventions aimed at reducing the likelihood of acl injuries. participants will undergo an injury risk screen, which is a standard component of the athletic camps sponsored by sanford sports and sanford orthopedics and sports medicine. this screen includes assessments of muscle strength and movement biomechanics, along with the collection of demographic and sports participation data. participants will then receive follow-up surveys at six and twelve months to report any new injuries. the study is designed to provide essential normative data, which is currently lacking, particularly for tests used in the assessment of aclr patients. this data will enhance clinicians' ability to evaluate a patient's readiness for return to sport by comparing their performance to robust normative values. additionally, the study will collect data on other risk factors, such as a history of concussions, to better understand the interplay between these factors and biomechanics in acl injury risk. by establishing this comprehensive database, the study aims to improve patient care by informing acl and aclr treatment and return-to-play guidelines, ultimately reducing the risk of acl re-injury in athletes.

Eligibility criteria:
inclusion criteria: * healthy athletes participating in formal, organized, competitive sports between the ages of 10 and 65 years old exclusion criteria: * athletes who are injured at the time of consent and pregnant individuals

Keywords: athletes biomechanics
translational research grics-cinecardiac

Conditions: Feasibility of GRICS CardioCine on Patients with Ischemic or Dilated Cardiopathy

Summary: this project is a pilot study which aims at showing the feasibility of free breathing cardiac mri using grics (generalized reconstruction by inversion of coupled system)software in a clinical environment. the grics technique has been developed by the iadi (diagnostic, adaptive and interventional imaging)lab, nancy, france. it enables free breathing mri thanks to a reconstruction algorithm which provides artefact-free images based on raw mr data and physiological data from external sensors (respiratory belts, ecg. in this study, we want to acquire free breathing cardiac cine images during a standard cardiac mr exam and compare those data with the breath-hold ones.


Eligibility criteria:
inclusion criteria: * candidate to cardiac mr exam because of ischemic or dilated cardiopathy * legally an adult * having heath insurance * having signed the consent form exclusion criteria: * dyspnea * atrial fibrillation * pain while lying on the back for a long time * inability to follow a procedure * contraindication to mri * contraindication to gadolinium chelate injection
graftless lateral maxillary sinus lift balloon by different antrostomy sizes with simultaneous implant placement

Conditions: Atrophy of Edentulous Maxillary Alveolar Ridge

Summary: two groups undergo for graftless sinus lift using ambe (antral membrane balloon elevation) through different antrostomy size with simultaneous implant placement

control group undergoes for graftless sinus lift using ambe through large antrostomy with simultaneous implant placement. while, study group undergo for graftless sinus lift using ambe through small antrostomy with simultaneous implant placement. the aim of the study is assessment the effect of antrostomy size on bone formation in graftless sinus lift with simultaneous implant placement. cbct will be done before and after the surgery and after 6 months to assess of amount bone gain in mm. implant stability after 6 months will be determined by using osstell. primary outcome: amount of bone gain which will be measured by using linear measurement from cbct. secondary outcome: stability of implant by using osstell

Eligibility criteria:
inclusion criteria: 1. patients with atrophic maxilla and pneumatization of maxillary sinus with residual bone height from 3-6mm. 2. both sexes 3. no intraoral soft and hard tissue pathology, 4. no systemic condition that contraindicate implant placement exclusion criteria: 1. sinus pathology. 2. heavy smokers more than 20 cigarettes per day. 3. patients with systemic disease that may affect normal healing. 4. psychiatric problems. 5. disorders to implant are related to history of radiation therapy to head and neck neoplasia or bone augmentation to implant site

Keywords: sinus augmentation,lifting
effects of insufflated gas on core temperature and post-operative pain during laparoscopic surgery

Conditions: Laparoscopy; Pain, Postoperative; Hypothermia

Summary: during laparoscopy, administration of cold and dry carbon dioxide (co2) leads to hypothermia. different types of gas conditioning have been studied in order to prevent this specific hypothermia. intra-abdominal administration of local anesthetics has also been studied in order to prevent post-operative pain. in both cases, some results have been described. the investigators propose to evaluate in a prospective, randomized, double blind trial, the impact of 4 different types of conditioning of insufflated gas during laparoscopy for womb surgery on hypothermia prevention and post-operative pain. these 4 types of gas conditioning are: * co2 wet and cold with nebulized nacl and direct intra-abdominal administration of nacl * co2 wet and cold with nebulized ropivacaïne 0.75% and direct intra-abdominal administration of nacl * co2 dry and cold with direct intra-abdominal administration of ropivacaïne 0.2% * co2 dry and cold with direct intra-abdominal administration of nacl the investigators use a new device (aeroneb® pro \[aerogen® company\]) which can wet (by nebulization) the insufflated gas and therefore permits intraperitoneal medicament administration (local anesthetics).


Eligibility criteria:
inclusion criteria: * womb surgery by laparoscopy * female * aged over 18 years * no emergency exclusion criteria: * laparotomy * protocol rejected by the patient * request of the surgeon or the anesthesiologist to know the administration solution or the insufflated gas

Keywords: comparison of four conditionings of the insufflated gas during laparoscopy and their consequences on the core temperature and the post-operative pain. women with womb pathology needing laparoscopic surgery no emergency aged over 18 years
kinesiophobia in stroke patients and affecting factors

Conditions: Kinesiophobia; Stroke Patients

Summary: it was aimed to determine the presence of kinesiophobia that will affect the treatment in stroke patients and to investigate the relationship between these factors and kinesiophobia by examining factors such as postural control, depression, pain, and affected side that may cause kinesiophobia.

objective: this study was planned to investigate the relationship between depression, postural control, pain, affected side and kinesiophobia in stroke patients. material and method: thirty patients aged between 25-70 years who had a stroke at the earliest 6 months and who functional ambulation scale were level 2 and above according to the were included in the study. patients were selected by random sampling method from the relevant population. demographic data were obtained from all subjects who met the inclusion criteria. patients were evaluated kinesiophobia scores (tampa kinesiophobia scale (tkö) and vas-kinesiophobia assessment), depression severity (beck depression inventory), postural control loss (pass) and pain severity (vas).

Eligibility criteria:
inclusion criteria: * individuals who were diagnosed with hemiplegia or hemiparesis after svo, * at least 6 months after svo, * who were level 2 and above according to the functional ambulation classification, * who wanted to participate in the study voluntarily exclusion criteria: * anyone with a major neurological or rheumatological pathology (polyneuropathy, parkinson's, multiple sclerosis, rheumatoid arthritis, etc.) * affecting the musculoskeletal system other than stroke * who does not allow mental evaluation, cannot fill in the scales, * is illiterate, has aphasia, has a history of falling, * have any cardiac problems, * amputation in the lower extremities, * those with active malignancy and related chemo/radiotherapy, * the presence of accompanying lower motor neuron or peripheral nerve lesion, * any musculoskeletal problem and related pain (lumbar disc herniation, meniscus, etc.), * ındividuals with shoulder subluxation, shoulder-hand syndrome * those who refused to participate in the study

Keywords: kinesiophobia stroke patients pain postural control depression
additional effects of kinesio taping on knee joint proprioception and spatiotemporal gait parameters in patient with chrondromalacia patellae

Conditions: Chondromalacia

Summary: chondromalacia patellae (cmp), also known as runner's knee, is characterized by anterior knee pain (akp) and typically occurs in youngsters. causes of chondromalacia patellae include micro trauma wear and tear, post traumatic injuries and muscular imbalance. in chondromalacia patella pain is behind or around the patella caused by stress in the patellofemoral joint that usually provoked by climbing stairs, squatting, and sitting with flexed knees for longer time periods. patients of cmp presents with patellar mal-tracking, muscular weakness, proprioceptive deficit. exercise training has been proven beneficial for cmp patients but additive effect of kinesio taping along with exercise have not been seen yet in these patients. the study will help people with chondromalacia patellae to improve their quality of life. the findings will contribute to future research in chondromalacia patellae management.


Eligibility criteria:
inclusion criteria: * both genders * age: under 60yrs * pain while stair climbing, kneeling, squatting, changing position from sitting to standing and running exclusive criteria: * instability of tibiofemoral joint * subluxation of patellofemoral joint * patellar instability * previous surgery of lower limb * positive findings on examination of knee ligaments, menisci and bursa. exclusion criteria: -
titratable dosing in moderate to severe asthmatics

Conditions: Asthma

Summary: the purpose of this study is to compare the long term safety of symbicort with budesonide alone, in adolescents and adults with asthma.


Eligibility criteria:
inclusion criteria: * diagnosis of asthma and baseline lung function tests, symptoms and medication use as determined by the protocol * required and received treatment with inhaled corticosteroids within the timeframe and doses specified in the protocol exclusion criteria: * has required treatment with non-inhaled corticosteroids within previous 30 days, has sensitivity to drugs specified in the protocol or requires treatment with a beta-blocker. * has had cancer within previous 5 years or has a condition that may put the patient at risk in this study.

Keywords: asthma adults adolescents safety symbicort budesonide/formoterol budesonide