Kornimate/medical-research-clean huggingface dataset:
evaluation of high intensity focused ultrasound (hifu) in the treatment of rectal endometriosis

Conditions: Endometriosis, Rectum

Summary: rectal endometriosis (re) induces lesions associated with painful symptoms that can alter quality of life. high intensity focused ultrasound (hifu) is a non-invasive ablative procedure using a high-intensity ultrasound probe to induce tissue devitalization using acoustic cavitation and thermal ablation. focal one® is a transrectal hifu device, which is validated to treat prostatic cancer. the primary objective of this clinical investigation is to evaluate the safety of the hifu treatment of rectal endometriosis with focal one® hifu device.


Eligibility criteria:
inclusion criteria: * patients aged at least 25 years-old * rectal endometriosis in preoperative imaging, without other digestive locations (colon, ileum and small intentine) * symptomatic patient refusing hormonal treatment and/or surgery. * endometriosic nodule visible on echography with contrast and confirmed in gadolinium mri and difusion sequence (according to standardized protocol) * nodule with intrarectal protrusion of less than 50% (allowing the positioning of the probe in front of the rectal nodule) * distance from the upper pole to the anal margin ≤ 15 cm (measurement by mri with intra-rectal contrast) * no curent pregnancy (negative bhcg \<72h before the hifu procedure) and no pregnancy project within 6 months after the hifu procedure (post-treatment mri delay) * patient agreeing not to change her hormone treatment for the duration of the study. * patient accepting the study constraints * health insurance affiliated patient or beneficiary of an equivalent coverage exclusion criteria: * virgin patient * ongoing uro-genital infection * anorectal anatomy incompatible with hifu therapy * history of segmental rectal resection with mechanical anastomosis, shaving or discoid resection * patient with an implant within 1cm of the treatment area (stent, catheter, essure® contraceptive implants). * inflammatory colon disease (ulcerative colitis, crohn's disease and others) * latex allergy * patient with contraindications to mri * patient with contraindications to gadolinium injection * patient previously treated with hifu for a rectal endometriotic lesion * patient not speaking nor reading french * patient deprived of liberty following a legal or administrative decision * patient under guardianship or tutelage measure

Keywords: rectal endometriosis, hifu
post traumatic stress disorder and neural mechanisms involved in its treatment

Conditions: Post Traumatic Stress Disorders

Summary: the post traumatic stress disorder ptsd arises when the physiological response to stress does not come to its term. this study aims to explore the cognitive, psycho physiological and cerebral mechanisms involved in ptsd, in fear conditioning and face matching tasks, before and after treatment.ptsd patients will be recruited by pr jean-claude samuelian in his service at the conception hospital and by pr jean-michel azorin in his service at the sainte marguerite hospital (marseille) and will undergo either cbt or emdr within those same services. the tasks they will be asked to perform will study the psycho physiological, cognitive and central mechanisms involved in ptsd and its treatment. all in all, 17 healthy controls will be recruited as well as 17 ptsd patients for each of the two treatment group.in terms of perspectives, this study would help isolate neural systems functionally involved in ptsd and its treatment. a better knowledge of those mechanisms would set room for the optimization of the current ptsd treatment.


Eligibility criteria:
inclusion criteria: * french speakers * not hospitalized grown-up patients suffering from a post-traumatic stress disorder ( ptsd) connected to one event. * subjects controls: grown-up, mated with the patients in age (18 - 50 years; 4 years maximum of difference of age between a patient and his control), in sex and educational level (schooling of the 3rd level, at the level bac+8; 3 years maximum of difference of educational level between a patient and his control) exclusion criteria: * pregnancy * feeding * nobody under guardianship and grown-up persons being the object of a legal protective measure or not able to express their assent * alcoholic or addicted to drugs (including medicines) * other neurological disorders or psychiatric that post-traumatic stress disorder (for patients) * claustrophobia and contraindications in the irmf * subjects controls, no known psychiatric or neurological pathology, as well as no psychiatric history. * persons private of freedom by a court or administrative order, persons hospitalized without assent * unability to read french

Keywords: post traumatic stress disorder ptsd
muscular morphological ultrasound epidemiological study in dance professionals

Conditions: Femoracetabular Impingement

Summary: this research will determine the presence of groin pain in professional dancers, through a specific questionnaire on the hip joint. two groups will be formed made up of dancers over 18 years of age, men and women; one with groin pain and one without groin pain. all participants will undergo a functional muscle ultrasound study, where the thickness of the abdominal muscles, lumbar multifidus and gluteus medius and minor will be evaluated, and the relationship between ultrasound neuromuscular changes and groin pain will be verified

the objective of the study is to shed light on the to the complexity of the diagnosis that groin pain (gp) encloses, it is proposed to evaluate with functional muscular ultrasonography rehabilitative ultrasound imaging (rusi), the layer thickness of the gluteal musculature of the hip and the abdominal and lumbar muscles on a sample of professional dancers over 18 years of age with gp to check if there are differences with professional dancers without gp. expected goals: 1. identify the presence of gp in professional dancers. 2. to compare the ultrasound characteristics of the neuromuscular system between a sample of dancers with gp and a sample of dancers no gp. 3. verify the relationship between ultrasound neuromuscular changes with gp.

Eligibility criteria:
inclusion criteria: * volunteer professional dancers 18 years or older, and no maximum age limits exclusion criteria: * not signing the informed consent

Keywords: dancing groin pain ultrasonography
minitightrope suspensionplasty compared with lrti for the treatment of basilar thumb arthritis

Conditions: Arthritis; Joint Diseases

Summary: this prospective randomized trial aims to ascertain differences in outcome measures for the operative treatment of basilar thumb arthritis by comparing the two most common surgical treatments: lrti and mini tightrope suspensionplasty. the investigators will evaluate both subjective and objective data to determine if a particular surgical method offers more favorable outcomes.

the study will be a prospective randomized-controlled trial comparing lrti and mini tightrope suspensionplasty for the surgical treatment of basilar thumb arthritis. patients meeting operative criteria who present to level one orthopaedics at orlando health will be consented for study participation. subsequently, consented patients will be randomized into one of three treatment arms: lrti, suspensionplasty with one-suture construct and suspensionplasty with two-suture construct. the patient will be blinded prior to the procedure; however, the performing surgeon will not be able to be blinded. the patient will become un-blinded postoperatively when the performing surgeon informs them which method was used. the investigators will then follow the patients for 5 years to assess the primary and secondary outcomes (see below) and analyze the data with an intention-to-treat method before publishing the conclusions. follow-up visits will occur at two weeks, one month, three months, six months, one year, and five years. outcome measures will incorporate subjective and objective measures and will include the sf-36 and disabilities of arm, shoulder \& hand (dash) questionnaires, pinch/grip strength, visual analog pain scale, patient satisfaction and postoperative complications.

Eligibility criteria:
inclusion criteria: * radiographically diagnosed stage ii-iv basilar thumb arthritis as described by the eaton and littler classification system on either the right or left hand. exclusion criteria: * to have a history of prior surgical intervention for basilar thumb arthritis, trauma to the hand or wrist, or debilitating injury to the upper extremity. * patients under the age of 18 or with a history of a debilitating neurologic injury, either acute or chronic, to the upper extremity will be excluded. * patients that are non-operative candidates due to medical comorbidities will also be excluded.
oral device clinical trial

Conditions: Tonsil Disease; Dental Diseases; Adenoid; Disorder (and Tonsils)

Summary: the investigators are studying the use of a new medical device developed at nationwide children's. this technology has been licensed and produced by zotarix llc, a medical device company. it is designed to aid in retraction and provide protection of the lips during surgery. the investigators are not recording any of your identifiable personal health information except for the surgery date. this device, called the labraguard is a sterile, soft medical grade silicone, and no alternative device with these exact protective properties exists, and the investigators are trying to learn more about how it performs in different age children.


Eligibility criteria:
inclusion criteria: * subjects 21 years of age and under * having a surgical procedure done through the mouth where the lips are at risk of injury * performed by attendings from either the otolaryngology department or the dental department. * subject/subject's guardian provides consent to be in the study exclusion criteria: * allergy to silicone * unable to achieve good fit
delving into participation trends in renal cell carcinoma studies

Conditions: Renal Cell Carcinoma

Summary: the study seeks to delve into the firsthand experiences of patients diagnosed with renal cell carcinoma who partake in a separate clinical study featuring a specific medical intervention. the primary emphasis will be on meticulously tracking the rates of trial completion and withdrawal among these individuals. by joining this clinical trial, individuals have the unique opportunity to contribute to the betterment of future renal cell carcinoma patients and play an active role in advancing clinical research.


Eligibility criteria:
inclusion criteria: * patient has been diagnosed with renal cell carcinoma * patient is a minimum of 18 years or older * patient has self-identified as planning to enroll in a clinical study exclusion criteria: * patient does not understand, sign, and return consent form * inability to perform regular electronic reporting * patient is pregnant

Keywords: renal cell carcinoma
elekt-d: electroconvulsive therapy (ect) vs. ketamine in patients with treatment resistant depression (trd)

Conditions: Treatment Resistant Depression; Electroconvulsive Therapy; ECT; Ketamine; Psychiatric Disorder; Depression; Major Depressive Disorder; Major Depressive Episode; Unipolar Depression

Summary: the goal of the study is to conduct a comparative randomized trial of electroconvulsive therapy (ect) vs. ketamine for patients with treatment resistant depression (trd) in a real world setting with patient reported outcomes as primary and secondary outcome measures.

patients with treatment resistant depression who meet all inclusion criteria and do not meet any exclusion criteria will be randomized to either electroconvulsive therapy (ect) three times per week or ketamine infusion two times per week. patients will answer questionnaires about their symptoms prior to treatments. the acute treatment phase of the study will last three to five weeks. depending on response to treatment, some patients will be followed for an additional six months.

Eligibility criteria:
inclusion criteria: 1. written informed consent before any study related procedures are performed 2. inpatients or outpatients referred by their providers for ect treatment and eligible for ect treatment 3. males/females at least 21 years of age but no older than 75 years of age 4. meet dsm-5 criteria for major depressive episode as determined by both: a. a clinician's diagnostic evaluation and b. confirmed with the mini international neuropsychiatric interview (mini 7.0.2) 5. a current depressive episode that has lasted a minimum of 4 weeks 6. meet all of the following criteria on symptom rating scales at screening: a. montgomery asberg depression rating scale (madrs) score \>20 b. young mania rating scale (ymrs) of ≤ 5 c. montreal cognitive assessment (moca) of ≥18 7. have had ≥2 adequate trials of antidepressants or augmentation strategies during their lifetime. an adequate trial is defined as 4 weeks of medication at the minimum fda approved dose. this will be equal to a trial rating of 3 or more. 8. in the opinion of the investigator, the patient is willing and able to comply with scheduled visits, treatment plan, and other trial procedures for the duration of the study exclusion criteria: 1. meet dsm-5 criteria for bipolar disorder, schizophrenia, schizophreniform disorder, schizoaffective disorder, mental retardation, or pervasive developmental disorder 2. meets any exclusion criteria for ect or ketamine treatment as described in the clinical guidelines or according to investigator judgment 3. the patient is pregnant or breast feeding 4. the patient has a severe medical illness or severe neurological disorder 5. the patient has a known ketamine allergy or is taking a medication that may interact with ketamine 6. diagnosis of major depressive disorder with psychotic features during the current depressive episode 7. unable to give informed consent 8. was previously enrolled/randomized into the trial
changes in regional and global cardiac contractility after stimulation in scar zone with the noga system

Conditions: Myocardial Infarction

Summary: despite a decrease in voltage amplitude in post-infarction scar areas, greater voltage amplitudes are sometimes observed at the time of local extrasystoles mechanically induced by catheters. however, no study has investigated whether these electrical changes are associated with mechanical changes in local contractility. however, the voltage is closely correlated to the local contractile function as evidenced by the use of the noga system.


Eligibility criteria:
inclusion criteria: - patients who should undergo ventricular tachycardia (vt) ablation after a myocardial infarction according to current recommendations, namely: patients with ischemic heart disease (icd) and with episodes of sustained ventricular tachycardia responsible for internal electric shocks by the implantable automatic defibrillator (icd) (grade ib recommendation) or * patients with an mic and an icd, presenting a first episode of sustained ventricular tachycardia (grade iia, b recommendation) * affiliated with a social protection scheme * having signed an informed consent exclusion criteria: * contraindication or non-indication for ventricular tachycardia ablation * women who are pregnant or of childbearing age and without contraception, breastfeeding women * patients without ischemic heart disease * patients under guardianship, curatorship or legal protection.

Keywords: stimulation in cardiac scar area
phenotyping patients with alcohol and cannabis use disorders using the addictions neuroclinical assessment

Conditions: Alcohol Use Disorder; Cannabis Use Disorder

Summary: this 2-arm study will recruit participants with 1) alcohol use disorder and 2) cannabis use disorder for a 12-week cognitive behavioral therapy, following a thorough baseline assessments on executive function, incentive salience, and negative emotionality.

although effective evidence-based interventions have been developed for alcohol and cannabis use disorders, it is still unclear which individuals respond best to treatment. a recent model known as the addictions neuroclinical assessment (ana) proposes that assessing for differences in three neurofunctional domains (executive function, incentive salience, and negative emotionality) could allow for a stronger neuroscience-based framework for understanding heterogeneity in response to addiction treatments but this has never been tested prospectively. in this study, we will recruit two groups: (1) participants with alcohol use disorder (aud) and (2) participants with cannabis use disorder (cud). participants will undergo thorough baseline assessments of each of the three ana domains prior to evidence-based treatment for their respective disorders. individuals with aud will be treated with 12 weeks of cognitive behavioral therapy (cbt) for aud plus optional pharmacotherapy guided by a pharmacotherapy algorithm. individuals with cud will be treated with 12 weeks of cbt + motivational enhancement therapy for cud. the primary objective of the study is to assess whether baseline ana measures are associated with changes in drug consumption and craving over treatment.

Eligibility criteria:
inclusion criteria: 1. patient has been referred to or intends to participate in either the aud or cud integrated care pathway (and is therefore willing to participate in group psychotherapy). 2. able to communicate and provide informed consent in english. 3. 18 years of age or older. 4. willing and able to safely abstain from substances (other than nicotine or tobacco products), including alcohol and cannabis, for 12 hours prior to the eligibility and task-based assessments. 5. meets dsm-5 diagnostic criteria for aud (aud group) or cud (cud group) 6. meets criteria for risky drinking, defined as \> 10 drinks per week for females and \> 15 drinks per week for males on average over the past 30 days (aud group) or daily or near-daily cannabis use over the past 30 days, defined as ≥ 4 days of cannabis use per week on average (cud group) exclusion criteria: 1. active suicidal ideation at time of assessment. 2. suicide attempt within the past month. 3. unstable psychiatric or medical status (e.g., acute psychosis or mania) or unstable use of another substance that may interfere with participation in groups (e.g. active fentanyl use). 4. enrollment in another study that conflicts with the procedures or scientific integrity of this study. 5. individuals planning to be out of the province for a substantial amount of time during the treatment period will not be permitted to enroll.
immune responses to covid-19 vaccination in lymphoma patients

Conditions: Classical Hodgkin Lymphoma; Diffuse Large B Cell Lymphoma; Primary Mediastinal B Cell Lymphoma; High-grade B-cell Lymphoma; Burkitt Lymphoma; Follicular Lymphoma; Mantle Cell Lymphoma; Marginal Zone Lymphoma; Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma; Lymphoplasmacytic Lymphoma; Nodular Lymphocyte Predominant Hodgkin Lymphoma; Peripheral T-cell Lymphoma

Summary: this prospective observational study aims to evaluate the robustness and persistence of immune responses to vaccination, define factors associated with impaired immune responses and assess the incidence of covid-19 infections in vaccinated individuals. to do this, we will collect peripheral blood from patients with lymphoid cancers before and after their covid-19 vaccination. the blood will be explored in the laboratory for antibodies to sars-cov-2 and t-cell responses to the spike protein. detailed clinical information will also be collated on about their cancer and treatment.


Eligibility criteria:
inclusion criteria 1. patients having a confirmed diagnosis of either: a) hodgkin lymphoma b) aggressive b-cell lymphoma (e.g. burkitt's lymphoma, diffuse large b-cell lymphoma, grade 3b follicular lymphoma, de novo transformed follicular lymphoma) c) indolent b-cell lymphoma (e.g. all grades of follicular lymphoma except grade 3b, marginal zone lymphoma, lymphoplasmacytic lymphoma, chronic or small lymphocytic lymphoma, mantle cell lymphoma) d) mature t/nk-cell malignancy (any subtype) 2. patient must be ≥ 18 years. 3. patients will have provided written informed consent. exclusion criteria 1) serious medical or psychiatric illness likely to affect participation or that may compromise the ability to give informed consent.
virtual reality in end stage kidney disease

Conditions: End Stage Kidney Disease

Summary: the goal of this clinical trial to compare the social virtual reality and individual virtual reality in patients with end stage kidney disease who are hemodialysis. the main aim is to determine if there are differences in symptoms between the groups. participants will use virtual reality glasses for 30-45 minutes during dialysis sessions for 4 weeks.

in a single site, 2-arm (social virtual reality group; individual virtual reality group), parallel, randomized controlled trial we will enroll 60 subjects (n=30 per group) to assess the effects of social virtual reality to individual virtual reality on symptoms in participants with end stage kidney disease who are receiving hemodialysis. to compare the effects of social virtual reality to individual virtual reality on loneliness to explore the effects of social virtual reality to individual virtual reality on anxiety and depression. to compare the effects social virtual reality to individual virtual reality on quality of life.

Eligibility criteria:
inclusion criteria * diagnosis of end stage kidney disease with hemodialysis 3 times per week for at least 1 month exclusion criteria * acutely ill * active nausea * epilepsy
how well do patients with traumatic brain injury learn new material using learning styles in online science classrooms?

Conditions: Brain Injuries; Brain Injuries, Traumatic; Injury, Brain, Traumatic; Traumatic Brain Injury; Brain Injury, Chronic

Summary: the purpose of this study is to determine whether learning styles are effective in the treatment of traumatic brain injury (tbi) in an educational environment.

the purpose of this study is to determine the learning outcome and effectiveness of instructional design strategy using canfield's learning styles and gardner's multiple intelligences to accommodate tbi-induced cognitive impairments in an online science learning environment.

Eligibility criteria:
inclusion criteria: 1. people who have been diagnosed with mild traumatic brain injury (tbi). 2. people who are able to understand and sign an informed consent form. 3. people who have no other known neurological disorder (e.g. aphasia, stroke). 4. all participants must be 18-50 years old. 5. be able to speak and understand english, and 6. have use of a computer (mac or windows) and internet (www) access. exclusion criteria: 1. don't meet the inclusion criteria 2. other known neurological disorder (e.g. aphasia, stroke).

Keywords: cognitive rehabilitation learning styles learning modes learning modalities multiple intelligences educational intervention instructional design