Kornimate/medical-research-clean huggingface dataset:
value of ipack block (interspace between the popliteal artery and capsule of knee) with spinal anesthesia versus fentanyl based spinal anesthesia for knee arthroscopic meniscectomy

Conditions: Post Operative Pain

Summary: postoperative analgesia is provided by local anesthesia combined with intrathecal narcotics. in addition, for the first 24 hours, this combination has a parenteral opioid sparing effect. however, despite its benefits, this method has been associated to an increased incidence of urine retention, nausea, and vomiting, as well as pruritus. a new localized analgesic approach called as ipack (infiltration between the knee capsule and the popliteal artery) has been employed in practice.

the goal of this study was to compare fentanyl based spinal anesthesia to ipack block-based spinal anesthesia during knee arthroscopy. patients and methods: the study enrolled sixty patients with asa (i-ii) ranging in age from 25 to 60 years old after receiving ethical committee permission and written informed consent from patients. they were divided into two groups: group f (30 patients) received spinal anesthesia using hyperbaric bupivacaine 0.5% (3ml) with fentanyl (25ug) and group i (30 patients) received spinal anesthesia using hyperbaric bupivacaine 0.5% (3ml) with ipack block using plain bupivacaine 0.5% (15ml). results: in the first 4 hours postoperatively, there were no variations in vas scores between the two groups; however, following 4 hours and over the next 12 hours, group i, vas scores were lower. the amount of morphine used overall was lower in group i, which took longer than group f to reach initial rescue analgesia. the level of patient satisfaction 48 hours after surgery was higher in group i than in group f.

Eligibility criteria:
inclusion criteria: age from 25 to 60 years old, with asa physical status i-iii undergoing for knee arthroscopy exclusion criteria: patient refusal, neuromuscular diseases, allergies to local anesthetics, and contraindications to spinal anesthesia such as coagulopathy and severe mitral stenosis

Keywords: ipack block, spinal anesthesia, knee arthroscopy.
bk treatment study

Conditions: BK Viremia

Summary: our hypothesis is that 30 days of oral levofloxacin (fda approved antibiotic) in patients with persistent viremia (bk virus found in blood) will impair progress to bk virus induced kidney damage by significantly decreasing or eliminating bk virus in the blood.


Eligibility criteria:
inclusion criteria: * living and cadaveric kidney transplant recipients over the age of 18 years with bk viremia exclusion criteria: * female patients of childbearing age who are pregnant or in whom adequate contraception cannot be maintained. * patients with active infections, history of malignancy/posttransplant lymphoproliferative disease (ptld) serologic positivity to hiv. * patients with evidence of urinary tract obstruction causing allograft dysfunction, unless corrected by time of enrollment. * patients with clinical or morphological evidence of recurrence of primary disease. * patients with a history of allergic reaction to quinolone antibiotics. * patients with history of prolong qt interval * patients with recurrent hypoglycemic episodes * patients with history of myasthenia gravis * patients taking thioridazine

Keywords: bk viremia kidney transplantation bk viremia in kidney transplant recipients
randomized clinical trial comparing transradial catheterization with or without spasmolytic drugs

Conditions: Cardiac Catheterisation

Summary: single-center study, randomized, double-blind, placebo controlled, with patients undergoing diagnostic or therapeutic catheterization via the transradial approach. patients will be randomized into two groups: one group will receive the vasodilator nitroglycerin during the procedure (intervention group), and a second group will receive saline 0.9% in the same volume and time during the procedure (control group). will be evaluated: incidence of spasms of the radial artery, ability to perform the procedure without the need to change the access site, pain presented by the patient, time and total radiation of the procedure.


Eligibility criteria:
inclusion criteria: * indication for cardiac catheterization * suitable candidates for transradial approach exclusion criteria: * ami * intubated patients * complications during procedure (cardiac arrest, pulmonary edema, cardiogenic shock, stroke) * prior inclusion in this trial

Keywords: radial spasm
observational study of effect of radiation therapy to immuno status in hiv-cancer patients

Conditions: To Study Immunostatus of HIV-cancer Patients Who Recived RT Befor RT and Last Week of RT; To Study HIV Viral Load of HIV-cancer Patients Who Recived RT Befor RT and Last Week of RT

Summary: objectives: to study immunostatus (cd4) and hiv viral load in hiv-cancer patients before rt and last weeks of rt .


Eligibility criteria:
inclusion criteria: * age 18-65 years * hiv positive cancer patients * photon beam rt, conventional fraction \>= 4000 cgy in 4 weeks exclusion criteria: * cd4 count \< 200 cell/ml and not received anti retro viral
effect of caffeine on heart rate variability in newborns

Conditions: Caffeine; Heart Rate Variability; Apnoea of Newborn; Newborn

Summary: the aim of this study was to evaluate the impact of caffeine treatment, given either orally or intravenously, on heart rate variability in newborns. in addition, the investigators sought for a potential association between caffeine treatment and vital functions.

at neonatal department of university medical centre ljubljana caffeine is used to treat neonatal apnoea. it has known affects on central nervous and cardiovascular systems, but little is known about the impact of caffeine intake on heart rate variability (hrv) in newborns. in this study, the investigators performed measurements on one sample of 25 newborns with apnoea who had been admitted to the neonatal department of university medical centre ljubljana and treated with caffeine citrate. the treatment regimen consisted of caffeine citrate of a loading dose of 20 mg/kg of body mass, followed by a daily maintenance dose of 5 mg/kg after 24 hours. the investigators measured parameters of hrv in two situations: while the treatment with caffeine citrate was ongoing and after the treatment was withdrawn. the newborns served as controls. electrical activity of the heart was measured with a holter ecg while the newborn was sleeping in supine position, first without a bed tilt and afterwards with a 30° head-up tilt. simultaneously was evaluated the alertness of the newborn and measured their physiological variables (the breathing frequency, the heart rate, the arterial oxygen saturation, and the body temperature). all parents were given their written consent for their child to participate in the study.

Eligibility criteria:
inclusion criteria: * newborns with apnoea treated with caffeine citrate * newborns whose parents have signed the informed consent form exclusion criteria: * severe perinatal hypoxia * infection * liver or renal insufficiency * neurological disorders * congenital anomalies

Keywords: newborn heart rate variability caffeine bed tilt autonomic nervous system
feasibility and initial clinical impressions of predictive monitoring integrated with the race team

Conditions: Deterioration, Clinical

Summary: rapid response teams (rrts) have been adopted by hospitals to provide urgent critical care to hospitalized patients who require quick intervention to prevent further deterioration. early warning scores (ews) serve as a method to identify patients requiring rrt assessment by analyzing routinely collected data such as vital signs and laboratory results. the visensia safety index (vsi) is an ews that uses continuous vital sign monitoring and machine learning to identify the likelihood of deterioration and can be integrated with existing hospital data infrastructure. initial studies of the vsi have both validated the system and found that patients monitored using vsi had a shorter duration of any instability and fewer episodes of serious and persistent instability. the investigators' recent retrospective analysis at the ottawa hospital (toh) identified that implementation of an ews could have detected earlier deterioration in over half of the patients identified, potentially preventing subsequent icu admission, severity of illness, and/or mortality. thus, this study aims to determine the feasibility and potential impact of implementing a portable continuous monitoring system with a vsi trigger at toh to identify patients at high risk of deterioration.


Eligibility criteria:
inclusion criteria: adult patient (greater than or equal to 18 years of age) designated for the most aggressive levels of potential intervention (category 1 status - full care and category 2 status - full care except cpr) who belong to one of the following groups: * patients who have undergone high risk elective surgery (whipple procedures, high risk vascular surgery, high risk general surgery, among others) * malignant haematology or oncology patients at high risk for deterioration * patients with infection admitted from the emergency department (ed) to the ward * other high-risk patients determined at the discretion of the clinical team exclusion criteria: * patients admitted to a unit with higher level monitoring (neurological acute assessment unit, acute monitoring area, trauma step-down, intensive care unit) * patients with category iii (full care except respiratory or hemodynamic life support, or cpr) or iv status (comfort care)
low level laser versus polarized light in the treatment of acne vulgaris

Conditions: Low Level Laser Therapy; Acne Vulgaris

Summary: the present study is designed to compare clinically the therapeutic applications between low level laser therapy (excimer laser) and non-laser polarized light (bioptron prol) in the treatment of acne vulgaris.

traditional acne treatment often involves topical application, which can cause skin irritation and dryness, and oral antibiotic therapy, which is limited by antibiotic resistance. newer procedures like laser and light-based therapies offer alternative treatments for patients who struggle with adherence or experience side effects or treatment failure. this study aims to compare the therapeutic application of laser and light therapies as an alternative to traditional acne treatments.

Eligibility criteria:
inclusion criteria: 1. female and male patients. 2. age range between 18 and 25 years. 3. all patients will sign their informed consent to participate in the research procedure and to publish the data. 4. definite clinical diagnosis of mild to moderate inflammatory lesions of facial acne vulgaris (open and closed comedones, papules, pustules, and nodules) on the face that has been going on for at least 1 month. exclusion criteria: 1. patient's unwillingness to continue cooperation in the study 2. photosensitive skin. 3. pregnancy and breast feeding. 4. women who use hormonal contraceptives. 5. patients who had used oral retinoids or any other treatment for acne in the last month. 6. patients with severe nodulocystic acne
bupivacaine supplementation for postoperative pain control in surgical removal of mandibular third molars

Conditions: Anesthesia, Local

Summary: control of postoperative pain is a foremost goal in achieving a satisfactory postoperative recovery. surgical removal of lower third molars is accompanied by postoperative pain that is at its peak in the first 12 hours. our study evaluates if the use of 2% lidocaine hydrochloride for the surgical removal of lower third molars with a postoperative 0.5% bupivacaine supplementation would result in lesser postoperative pain and a decrease in ingestion of oral analgesics to control the pain when compared to a placebo.

the study intends to enroll 100 patients \[asa 1\] with bilateral symmetrical impacted mandibular third molars requiring surgical removal under local anesthesia. 2% lidocaine hydrochloride with epinephrine bitartrate 1: 80000 in 3ml quantity will be utilized to achieve local anesthesia at the surgical site on both quadrants. additional supplementation postoperative at the surgical site will be provided with either 1.5 ml of 0.5% bupivacaine with 1:80000 epinephrine solution or saline based on a split mouth randomized study design using a color and number coded envelop. all procedures will be performed by a single surgeon using a similar technique, under identical conditions at one month apart intervals. pain scores will be assessed by the patient based on a 10cm visual analog scale at intervals of 2, 4, 6, 12, 24, 36, 48, 72, 96 and 120 hours. the duration of soft tissue anesthesia postoperatively will be recorded by the patient. the number of analgesics ingested over 120 hours will be recorded by the patient. results will be evaluated statistically by the wilcoxon test and two tailed test to determine the ratio. statistical significance will be considered at p \< 0.05.

Eligibility criteria:
inclusion criteria: * healthy asa \[american society of anaesthesiologists\] class 1 patients with mandibular bilateral, symmetrical, impacted third molars indicated for extraction. exclusion criteria: * unilateral impacted and bilateral asymmetrical impacted molars; * those who misused alcohol, had chronic pain, * those who took narcotic drugs, beta-blockers, or any analgesic drug within 24 hours before the operation * those with known hypersensitivity to amide types of local anesthetics.
comparative bioavailability of treprostinil diethanolamine manufactured by two independent facilities

Conditions: Pulmonary Arterial Hypertension

Summary: the purpose of this study is to compare the bioavailability of a single 1mg dose of treprostinil diethanolamine sustained release (sr) tablets manufactured by two independent facilities.


Eligibility criteria:
inclusion criteria: * subject is healthy and between the ages of 18 and 55 years, inclusive, at screening * female subjects must weigh between 45 and 100 kg, inclusive, with a bmi between 19.0-29.9 kg/m2, inclusive at screening. male subjects must weigh between 50 and 120 kg, inclusive, with a bmi between 19.0-32.0 kg/m2, inclusive at screening * subject has a medical history, physical examination, vital signs, ecg and clinical laboratory results within normal limits or considered not clinically significant by the investigator at screening exclusion criteria: * subject has any clinically relevant abnormality identified during the screening physical examination, 12-lead ecg, or laboratory examinations. * subject has a history of anaphylaxis, a documented hypersensitivity reaction, or a clinically significant idiosyncratic reaction to any drug * subject has a clinically significant history of neurological, cardiovascular,respiratory, endocrine, hematological, hepatic, renal, gastrointestinal,genitourinary, pulmonary, and/or musculoskeletal disease; glaucoma; a psychiatric disorder, or any other chronic disease, whether controlled by medication or not.

Keywords: treprostinil bioavailability bioequivalence
possible manifestation of rhinitis after nasal fracture

Conditions: Nasal Fracture

Summary: we would like to investigate our hypothesis of a higher prevalence of nasal fracture in the history of idiopathic rhinitis (ir) patients compared to healthy controls. therefore a retrospective analysis of 310 patients with a nasal fracture in the past would be useful to investigate the incidence of ir in this cohort afterwards (5-10 y later).

the patient population will be recruited by sending patient questionnaires (form in addendum) to patients who suffered a nasal fracture five to ten years ago (time period 2005-2013) with nose reposition afterwards under general anaesthesia in the chirurgical day care centre (cdc) of university hospital (uz) leuven. the control population (hc) will be recruited by sending a slightly adapted questionnaire (form in addendum) to patients who had surgery of the vocal cords under general anaesthesia in the cdc of uz leuven in the same period as the patient group. the control group will be age and sex-matched with the patient group.

Eligibility criteria:
inclusion criteria: * presence of nasal fracture in 2005-2013 and * diagnosis ascertained by a ear-nose-throat (ent) specialist and * followed by nose reposition surgery under general anaesthesia and * described in the clinical operation report as "mobile nose bones" or available radiography inclusion criteria of the control group: * presence of problem on vocal cords without previous nasal fracture * surgery of the vocal cords under general anaesthesia in 2005-2013

Keywords: surgery for nasal fracture
study to evaluate patient reported outcome (pro) and physical activity in japanese patients with hr+/her2- advanced breast cancer treated with palbociclib plus endocrine therapy or endocrine monotherapy

Conditions: Breast Cancer

Summary: the study is a prospective, multicenter, observational study to evaluate pro and physical activity using smartphone-based application and wearable device in japanese patients with hr+/her2- advanced breast cancer (abc). patients will be enrolled into either palbociclib plus endocrine therapy group (group 1) or endocrine monotherapy group (group 2) based on the discretion of the treating physician under routine clinical practice. total target number of patients is approximately one-hundred in this study (about 50 patients in each group). enrolled patients will download a smartphone-based application for electronic pro (epro), be provided access to and trained on the use of the application to complete baseline, weekly, and cycle-based assessments for 6 cycles (24 weeks). in addition, enrolled patients will be provided with wearable device and requested to wear the device at all-times, except of while bathing and sleeping, for 6 cycles (24 weeks).


Eligibility criteria:
inclusion criteria: 1. adult women (≥ 20 years of age) 2. diagnosis of adenocarcinoma of the breast with evidence of metastatic disease or advanced disease not amenable to resection or radiation therapy with curative intent. 3. documented evidence of hr+/her2- tumor based on the patient's surgical specimen or most recent tumor biopsy. 4. initiating first or second line treatment at study entry with one of the following therapies: palbociclib plus endocrine therapy or endocrine monotherapy 5. eastern cooperative oncology group (ecog) performance status = 0\~1. 6. owns or has regular access to an apple iphone or android phone. 7. willing and able to complete collection of data via smartphone-based application. 8. willing and able to wear the wearable device for approximately 6 months. 9. evidence of a personally signed and dated informed consent document indicating that the patient has been informed of all pertinent aspects of the study. 10. able to read and understand japanese exclusion criteria: 1. the patient is participating in any interventional clinical trial that includes investigational or marketed products. patients participating in other investigator-initiated research or non-interventional studies can be included as long as their standard of care is not altered by the study. 2. the patient is on active treatment for other malignancies other than abc. 3. the patient's life style is fluctuating in weekly-basis (eg, shift-time worker), which may have high impact on physical activity assessment based to investigator's discretion

Keywords: prospective multicenter observational study japan hormone receptor - positive/human epidermal growth factor 2 - negative (hr+/her2-) advanced breast cancer palbociclib european organisation for research and treatment of cancer quality of life questionnaire-30 (items) (eortc-qlq-c30) physical activity
effect of non surgical periodontal therapy on inflammatory markers in chronic periodontitis patients

Conditions: Aggressive Periodontitis

Summary: the current study was performed to study levels of il-17 and il-18 in aggressive periodontitis patients before and after non surgical periodontal therapy

background:host defense factors are involved in pathogenesis of chronic periodontitis so, the current study is assessing levels of il-17 and il-18 in chronic periodontitis patients versus periodontally healthy controls. subjects and methods: fifty subjects were included; twenty five of them are diagnosed with chronic periodontitis patients and twenty five are periodontally healthy subjects. probing depth (pd), clinical attachment level (cal), plaque index (pi) and gingival index (gi) were recorded for all the enrolled subjects. gcf levels of il-17 and il-18 were analyzed by enzyme-linked immunosorbent assay (elisa).

Eligibility criteria:
inclusion criteria: * medically free subjects . * both genders . * age range between 30 to 60 years old . exclusion criteria: * subjects with periodontal surgeries in the last 6 months. * subjects with prior use of antibiotics in the last 6 months. * smokers. * pregnant and lactating females were excluded. * lactating females.
investigation of the efficiency of radial extracorporeal shock wave therapy at different pulses in carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: different parameters have been used in studies investigating the efficacy of extracorporeal shock wave therapy in the treatment of carpal tunnel syndrome. although extracorporeal shock wave therapy has been shown to have a positive effect on carpal tunnel syndrome, there is no consensus on which pulse rate is more effective. therefore, in this study, the efficacy of extracorporeal shock wave therapy applied at different pulse rates in the treatment of carpal tunnel syndrome will be examined.

the study included 72 patients with cts aged 18-65 years who applied to kırşehir ahi evran university training and research hospital physical therapy and rehabilitation center. carpal tunnel syndrome (cts) is the most common compressive neuropathy. in cts, the median nerve is compressed within the carpal canal, about 1 to 2 cm beyond the distal wrist crease. it is more common in women and is typically more severe in the dominant hand but is often bilateral. repetitive hand and wrist movements, such as using a keyboard or vibrating tools, have been associated with cts. medical conditions associated with cts include diabetes, hypothyroidism and ra, as well as obesity and pregnancy. rarely, cts may be caused by a mass lesion in the wrist, such as a ganglion cyst or neurofibroma, or may be associated with acute trauma to the wrist. the vast majority of cts cases are idiopathic. cts treatment is divided into conservative and surgical treatment. conservative treatment methods are recommended in mild and moderate cts patients, while surgical treatment is recommended in severe cases. extracorporeal shock wave therapy is one of the physical therapy applications used in the treatment of carpal tunnel. the effectiveness of eswt in the treatment of cts will be examined

Eligibility criteria:
inclusion criteria: * male and female patients aged 18-65 years with carpal tunnel syndrome diagnosed clinically and by emg * patients who can correctly understand what is stated in the patient information form and who can cooperate * patients who consent to participate in the study according to the informed consent form will be included in the study. exclusion criteria: * cervical radiculopathy * polyneuropathy * brachial plexopathy * use of systemic corticosteroids or local corticosteroid injections * history of fracture and trauma in the forearm and wrist on the treated side * inflammatory rheumatic disease * pregnant and lactating patients * systemic diseases such as renal failure, peptic ulcer, dm, hypothyroidism, coagulation disorder * patients undergoing carpal tunnel syndrome surgery * people with pacemakers * thoracic outlet syndrome * tenar atrophy, severe carpal tunnel syndrome

Keywords: rehabilitation extracorporeal shock wave therapy physical therapy