Kornimate/medical-research-clean huggingface dataset:
clinical evaluation of ventricular septal defect (vsd) in children at sohag univesity hospital

Conditions: Ventricular Septal Defect

Summary: ventricular septal defect(vsd) are one of the most common significant chd and account for up to 40% of all cardiac abnormalities.vsd is commonly isolated defect as well as intrinsic component of several complex cardiac malformations including tetrology of fallot ,double- outlet right ventricle(rv),transposition of great vessles,aortic coartication or interruption ,and truncus arteriosus


Eligibility criteria:
inclusion criteria: * all children from date of birth to age of 16 years old including both genders diagnosed to have isolated vsd or apart from another cardiac anomalies exclusion criteria: -
low serum ficolin-3 levels on admission are associated with poor outcomes after severe traumatic brain injury

Conditions: Brain Injuries

Summary: the current study was designed to investigate the change of serum ficolin-3 levels and assess the prognostic predictive effect of serum ficolin-3 levels in the patients with severe traumatic brain injury.

complement activation is one of the pathological mechanisms that contribute to the secondary brain injury after traumatic brain injury. ficolin-mediated lectin pathways of complement activation contribute to the pathogenesis of ischemic stroke and may be additive to complement-independent inflammatory processes. lower serum ficolin-3 levels have been demonstrated to be highly associated with unfavorable outcome after ischemic stroke. this prospective observatory study was designed to investigate the relationship between serum ficolin-3 levels and 1-week mortality, 6-month mortality and 6-month unfavorable outcome (defined as glasgow outcome scale score of 1-3) in patients with severe traumatic brain injury. this study recruited 128 patients and 128 sex- and age- matched healthy controls. serum ficolin-3 levels on admission were measured by sandwich immunoassays. it was postulated that serum ficolin-3 levels were correlated with glasgow coma scale scores and ficolin-3 was identified as an independent prognostic predictor for 1-week mortality, 6-month mortality and 6-month unfavorable outcome. thus, it was proposed that lower serum ficolin-3 levels, correlated with injury severity reflected by glasgow outcome scale scores, had the potential to be the useful, complementary tool to predict short- or long- term clinical outcome after severe traumatic brain injury.

Eligibility criteria:
inclusion criteria: * isolated head trauma * postresuscitation glasgow coma scale score of 8 or less. exclusion criteria: * less than 18 years of age * admission time \> 6 hours * previous head trauma * neurological disease including ischemic or hemorrhagic stroke * use of antiplatelet or anticoagulant medication * diabetes mellitus * hypertension * presence of other prior systemic diseases including uremia, liver cirrhosis, malignancy, and chronic heart or lung disease
variables predicting reintubation after thymectomy in patients with myasthenia gravis

Conditions: Myasthenia Gravis

Summary: myasthenia gravis (mg) is an autoimmune disease that is characterized by muscle weakness and fatigue. the role of the thymus in mg has been suggested by the evidence that 10% to 15% of patients present with a thymoma and at least 60% with thymus hyperplasia or dysplasia.beneficial effects of thymectomy in patients with mg have been described in 40% to 90%.few studies have looked at the incidence of reintubation (not just within 24 hours after extubation), the factors associated with reintubation, and patient outcome. premature extubation may lead to hypercarbia, hypoxemia, pulmonary hypertension, right heart failure, and myocardial ischemia. additionally, it subjects the patient to the physical risks of reintubation, including esophageal intubation, laryngeal trauma, and pulmonary aspiration. the purpose of the present study was to determine the incidence of reintubation, the variables associated with reintubation, and patient outcome

inclusion was based on the availability of all the following possible predictive pre-operative variables: age, gender, weight, height, body mass index, diabetes, creatinine, duration of mg, severity of mg (based on osserman's classification), pathological type of mg, history of myasthenic crisis, dose of pyridostigmine, use of a steroid hormone, and use of an immunosuppressant.operative variables: postoperative pulmonary infection, total duration of hospital stay, duration of icu stay, and duration of postoperative hospital stay. variables were collected by research assistants and maintained in a computer database.

Eligibility criteria:
inclusion criteria: * younger than 75 years * absence of heart failure as the primary indication for mechanical ventilation •acute physiology and chronic health evaluation (apache) ii score less than 12 points on day of extubation * body mass index less than 30 exclusion criteria: •preoperative moderate-to-severe chronic obstructive pulmonary disease

Keywords: prediction myasthenia gravis reintubation
the effect of mastiha oil in metabolic syndrome

Conditions: Metabolic Syndrome

Summary: mastiha oil is a 100% natural product of the mediterranean, extracted from the resin of mastiha. over 90 compounds have been identified in mastiha oil, with monoterpenes exhibiting favorable effects in regulating mechanisms of oxidative stress and inflammation. the aim of this study is to determine the effect of mastiha oil in adults with metabolic syndrome. 90 participants will be allocated to two groups, (45 in intervention group and 45 in control group). mastiha oil will be provided in the form of soft gel capsules to the intervention group, whereas the control group will not consume the capsules. both groups will receive standard nutritional counselling. the intervention will last 3 months. the effects of the intervention will be evaluated via clinical and laboratory markers.


Eligibility criteria:
inclusion criteria: * 30 years \< age \< 75 years * metabolic syndrome cardiometabolic parameters * a stable weight for ≥ 3 months pre-intervention * an unchanged treatment regimen for ≥ 6 months pre-intervention exclusion criteria: * hepatotoxic medication * untreated diabetes mellitus * dysthyroidism, hypopituitarism, cushing syndrome / disease * pregnancy, lactation * psychiatric or mental disorder * any use of antioxidant-phytochemical rich supplement, vitamin d supplement, anti-, pre- or pro-biotics within 3 months pre-intervention
efficacy and safety of fluvastatin sodium extended release tablets 80 mg once daily in chinese patients with primary hypercholesterolemia or mixed dyslipidemia

Conditions: Lipid Metabolism Disorders

Summary: this study is to demonstrate therapeutic comparability of fluvastatin sodium extended release tablets 80 mg qd and fluvastatin sodium immediate release capsules 40 mg bid in ldl-c lowering from baseline to week 12 (endpoint) in patients with primary hypercholesterolemia or mixed dyslipidemia at moderate or high cv risk who did not achieve their lipid goals when treated with fluvastatin sodium immediate release capsules 40 mg qd.


Eligibility criteria:
inclusion criteria: * patients with primary hypercholesterolemia or mixed dyslipidemia at moderate or high cv risk according to chinese dyslipidemia guideline (2007). * not having achieved lipid treatment goals despite following a cholesterol restrictive diet and/or lipid lowering monotherapy improperly prior to visit 1 (inclusion in the 6-week open-label study phase). * not having achieved lipid treatment goals on a stable dose of fluvastatin sodium immediate release capsule 40 mg qd during the 6 week open-label study phase (inclusion in the 12-week double-blind study phase). exclusion criteria: * patients with known hypersensitivity to fluvastatin or any of the excipients. * dyslipidemia secondary to other causes. * known muscle disease or history of muscle disease and/or serum cpk levels greater than 2 x upper limit of normal (uln). * a history or evidence of acute myocardial infarction (ami), unstable angina (ua) or coronary artery bypass surgery or percutaneous coronary intervention (pci) within the previous 8 weeks. * active liver disease and/or serum transaminase levels (alt, ast) greater than 1.5 x uln. * patients on a proper lipid lowering monotherapy (defined as at least 12 weeks continuous monotherapy with a recommended dose and administration in the label) within the previous 3 months prior to visit 1. other protocol-defined inclusion/exclusion criteria may apply.

Keywords: dyslipidemias fluvastatin sodium chinese
differences in quality of life after thoracic outlet syndrome surgery

Conditions: Thoracic Outlet Syndrome

Summary: quality of life evaluation after thoracic outlet surgery with quick-dash and sf-36 forms


Eligibility criteria:
inclusion criteria: * thoracic outel syndrome surgery scheduled in the vascular and thoracic surgery department of angers ; age \> 18 y ; french language understood exclusion criteria: * denied of consent
effects of core stability versus swiss ball exercise in patients with chronic neck pain

Conditions: Neck Pain

Summary: the study will be a randomized clinical trial to determine the effects of core stability versus swiss ball exercises on pain, range of motion and function in patients with chronic neck pain. a sample of 42 patients having neck pain since last 3 months will be taken from physical therapy department of "bahawalpur medical \& dental hospital" and will be divided into two groups each with 21 patients. patient of any gender(male or female) with no history of neck surgery or any systemic disease will be considered. group a will receive core stability exercises along with conventional physical therapy while group b will receive swiss ball exercises along with the conventional physical therapy protocol. the conventional physical therapy protocol will include a hot pack, and cervical stretches. the session will be around 30-45 minutes for each patient with three sessions per week on alternate days. a total of four-week treatment regime will be given to the patients and an assessment of patient's pain, range of motion, and function with nprs (numeric pain rating scale), goniometry, and ndi (neck disability index) will be done at the baseline and after 4 weeks of treatment, data will be analyzed by using spss version 21, after the completion of treatment at four weeks.

chronic neck pain is one of the pains with the highest prevalence these days due to the imprecise daily life routine of people including students \& office workers etc. it is generally declared that pain and stiffness in neck occur due to faulty posture for prolonged periods of time against the gravity. deep layered muscles e.g longus capitus, longus colli, rectus capitus anterior \& rectus capitus lateralis provides the stability to neck if they are targeted it is believed that the observed problem can be cured. this study is aimed to compare two methods for stability of neck i.e. core stability exercises \& swiss ball exercises. until now many treatment options have been used for chronic neck pain e.g stretching, isometrics, fascia release, mobilization techniques etc, and in recent literature, it is seen that stability of neck muscles are emerging to alleviate chronic neck pain. this study is aiming to compare the effects of core stability exercises and swiss ball exercises.so, the latest , effective and economical options for treatment can be used by the physical therapists and can be guided to the patients in order to gain long-lasting effects.

Eligibility criteria:
inclusion criteria: * • both genders (male \& female) * age group 20-40 years * history of neck pain for more than 3 months exclusion criteria: * history of any neck surgery * neoplasms * any systemic disease * bony disorders

Keywords: neck pain posture range of motion core stability
safety and tolerability study of 131i-tm-601 to treat adult patients with recurrent glioma.

Conditions: Glioma; Brain Neoplasm

Summary: this drug is being developed to treat a type of brain cancer, glioma. this study was designed to determine a safe and well tolerated dose. patients must have had prior treatment for their glioma and be eligible for removal of their recurring tumor.

this is an open label single-dose study to be conducted in 18 evaluable patients with recurrent high-grade glioma. patient will undergone debulking surgery and ventricular access device placement into the tumor cavity for administration of 131i-tm-601. high-grade glioma includes glioblastoma multiforme, anaplastic astrocytoma, anaplastic oligo-astrocytoma and gliosarcoma. the amount of 131i will remain constant. three doses of tm-601 will be administered using a dose escalating scheme.

Eligibility criteria:
* patient must have given informed consent * patient must have histologically confirmed supratentorial malignant glioma * patients must have recovered from toxicity of prior therapy * patients must be eligble for resection of the recurrent tumor

Keywords: brain neoplasm clinical trial, phase i/ii
induction to labour with double cervical ballon at home versus at hospital

Conditions: Induced; Birth; Cervical Dilatation; Live Birth

Summary: the goal of this clinical trial\] is to compare the outcomes between induction to labour at home versus hospitalized. the main questions it aims to answer are: * can the induction to labour at home with cervical rippening ballon increase the vaginal delivery rate? * will the induction to labour at home increase maternal satisfaction * will the induction to labour at home improve medical circuits and coulb it be cost effective? participants who meet inclusion criteria will undergo randomization so as to be asignated an induction to labour at home or in the hospital. researchers will compare both labour induction groups to see if the induction to labour at home has better outcomes as described previously.

indobamhos is a multicentric randomized clinical trial which is based in the principle that cervical rippening with intracervical probes with ballons is as safe as pharmacological induction with pge2 and it seems to be a suitable option to develop the cervical rippening process of the induction at home rather than in the hospital. the purpouse of the study is to demonstrate that the comfort of performing the cervical rippenning at home will benefit patients with an increase of the vaginal delivery rate and increases maternal satisfaction. and also will improve medical circuits and could be cost-effective when compared to hospitalized labour induction.

Eligibility criteria:
inclusion criteria: * pregnant women with ages \>18 y.o * being able to read and understand the informed consent * accept to join the study when signing the informed consent * singleton * cephalic presentation * weeks of gestation between equal or more than 37 and less than 42 * low risk indication of labor induction: cronologically prolonged gestation * intermediate risk indication of labor induction: macrosoma, elevated maternal age, intrahepatic gestacional colestasis, gestational diabetes mellitus treated with diet, gestational diabetes mellitus with insulin therapy and correct metabollic controls, small for gestacional age fetus, stable chronic hypertension, anterior caesarean section exclusion criteria: * premature rupture of membranes (prom) * breech presentation * unstable presentation * polihydramnios * severe congenital fetal afection * fetal growth restriction * suspected fetal well-being loss on ctg * bishop score equal or higher than seven before insertion of the crb * high cephalic presentation * home further than 30min from hospital * preeclampsia * diabetes mellitus type 1 * maternal hypertension * other maternal pathology with severe compromise * vaginal delivery exclusion: * oclusive and non-occlusive placenta previa (marginal or low insertion) * vasa previa * transverse / oblique situation * cord prolapse * history of previous caesarean section with uterine incission in inverted t * history of uterine rupture * two or more previous caesarean section * active genital herpetical infection
nutritional optimization and bone health management for older adults undergoing hip fracture surgery

Conditions: Hip Fractures

Summary: the overall objective of this pilot study is to test a comprehensive nutritional intervention in elderly patients diagnosed with hip fracture, which the study team believe will reduce functional decline, morbidity and mortality.

this collaborative pilot study is led by a pi who is a board-certified orthopaedic surgeon with extensive experience in the care of older adults with hip fractures. in addition, the multidisciplinary study team includes a research health scientist with vast experience in nutrition, preventive health, and gerontology. the study team will also be supported by a physical therapist and researcher in the field of rehabilitation of older adults with musculoskeletal disorders. furthermore, an occupational therapist with expertise in rehabilitation science, conduct of pilot studies, and analysis of interview data will play an important role in this study. moreover, the statistical analyses will be performed by an expert statistical consultant from our institution, who will be reimbursed on a fee for service basis.

Eligibility criteria:
inclusion criteria: 1. provision of signed and dated informed consent form 2. male or female, aged 65-89 years 3. closed fracture of the proximal femur including the anatomic areas of femoral neck, intertrochanteric and subtrochanteric region 4. patient indicated for surgical treatment (surgical fixation or arthroplasty) as per orthopaedic surgeon 5. ability to take oral medication and be willing to adhere to the study drug regimen and to the nutritional guidance provided by nutritional experts. exclusion criteria: 1. patients with open fractures 2. surgical treatment other than surgical fixation or arthroplasty, such as proximal femur resection 3. known allergic reactions to components of the study drugs or who do not tolerate oral nutritional supplementation (e.g. total parenteral nutrition or food allergies) 4. decisional impairment 5. prisoners

Keywords: older adults hip surgery
linear running periodization x nonlinear

Conditions: Healthy

Summary: in a competitive scenario, trainers and coaches seek to improve the performance of their athletes organizing macrocycles (year), mesocycles (months), and microcycles (weeks) training aimed at a specific moment of a competition. the organization variables, mainly the intensity of exercise in a training routine can stimulate important physiological pathways and uphold superior gains to vo2max, leading to a peak aerobic performance. however, due to lack of evidence, and the difficulty of control on a large scale, the effects of the intensity organization over a mesocycle periodization are still poorly investigated.

the objective of this study is compare two intensity blocks organization a) linear progression intensity (lp) and b) randomized or not intensity linaer (nlp) over five months running training, and a crossover design between subjects, on gains in vo2max, peak velocity (vpeak) and critical power (cp). furthermore, the relationship between the gains obtained with the training and the amount of exercise will be established. in our case all dependent variables will increase after training, with no significant differences between the two strategies on dependent variables.

Eligibility criteria:
inclusion criteria: * minimum standards of physical activity proposed by the acsm * 18-45 years * no metabolic or cardiovascular events * no use ergogenic resources exclusion criteria: * sedentary * diagnosis of cardiac, pulmonary or diabetes type i or ii * no injuries

Keywords: vo2max physical conditioning aerobic exercise performance
narcolepsy nightmare study

Conditions: Narcolepsy; Narcolepsy Type 1; Narcolepsy With Cataplexy; Narcolepsy Type 2; Narcolepsy Without Cataplexy

Summary: the goal of this clinical trial is to test two behavioral treatments for nightmares in adults with narcolepsy. the main questions it aims to answer are: * is imagery rehearsal therapy (irt) effective for narcolepsy-related nightmares? * does adding targeted dream control (tdc) to irt make it more effective? participants will be randomized to one of two treatment groups and will be asked to: * complete a daily log of sleep symptoms for up to 13 weeks. * attend 7 sessions of treatment. * complete questionnaires before and after treatment. * go to the research lab in evanston, il to complete a sleep study during a daytime nap (chicago area residents only).


Eligibility criteria:
inclusion criteria (all participants): * diagnosis of narcolepsy * age 18 or older * speak english * live in the united states * receiving standard medical care for narcolepsy * sleep and psychiatric medications stable for at least 3 months * nightmare frequency of ≥3 times per week * nightmare disorder index score indicates probable nightmare disorder inclusion criteria (chicago area participants): * able to attend a study appointment in evanston, il * able and willing to not take wake-promoting medications on day of lab visit exclusion criteria: * history of a neurological disorder that might alter eeg * currently engaged in sleep- or trauma-focused psychotherapy * previous behavioral treatment for nightmares * medical, psychiatric, or cognitive condition which would interfere with ability to engage in the treatment * untreated sleep apnea (ahi ≥ 5)
reduced port laparoscopic gastrectomy for gastric cancer

Conditions: Laparoscopic; Gastrectomy

Summary: reduced port laparoscopic gastrectomy has been adopted in clinical. the safety and outcome of reduced port laparoscopic gastrectomy has not been systematically evaluated. the investigators sought to compare the short and long-term outcome of patients with gastric cancer who underwent reduced port gastrectomy with patients underwent traditional laparoscopic gastrectomy

reduced port laparoscopic gastrectomy has been adopted in clinical. the safety and outcome of reduced port laparoscopic gastrectomy has not been systematically evaluated. the investigators designed a comparative study, which sought to compare the short and long-term outcome of patients with gastric cancer who underwent reduced port gastrectomy with patients underwent traditional laparoscopic gastrectomy. the short-term outcome include surgical complications, postoperative morbidity, postoperative nutrition. the long-term outcome mainly include long-term survival.

Eligibility criteria:
inclusion criteria: 1. histologically confirmed adenocarcinoma of the stomach, t1-t4 stages. 2. eastern cooperative oncology group performance status of 0 or 1. 3. adequate organ function. exclusion criteria: 1. patients had distant metastasis. 2. oesophageal invasion of more than 3 cm. 3. borrmann type 4 or large (more than 8 cm) type 3 carcinoma. 4. previous chemotherapy or radiation therapy for any other malignancies.