Kornimate/medical-research-clean huggingface dataset:
foot muscle strengthening exercises for pes planovalgus

Conditions: Pes Planus

Summary: pes planovalgus is a common foot condition affecting the child population. it is characterized by the partial or complete collapse of the medial longitudinal arch with rearfoot eversion and forefoot abduction, which is associated with changes in lower extremity kinematics during dynamic activity. the lower extremity chain includes the foot, ankle, knee, and hip joints, with the feet acting as the base of support. however, due to their small size, maintaining balance can be challenging. any small dynamic change in the foot, as the support base, can impact overall body posture. the foot arch, which can be pronated or supinated, affects proprioceptive input by altering joint movement, contact area, and muscle strategy for stability. pes planovalgus, characterized by excessive subtalar pronation, lead to instability and hypermobility, requiring more neuromuscular control to maintain balance. as a result, flat feet can cause pathomechanical issues and compensatory actions in the lower extremity chain, affecting overall body balance. the effectiveness of exercise interventions, particularly foot intrinsic muscle strengthening exercises, in increasing the medial longitudinal arch in individuals with pes planus has been investigated in numerous studies. it is widely accepted that both intrinsic and extrinsic muscle groups play a crucial role in the formation, maintenance, and enhancement of foot arches. however, there is a lack of studies specifically examining the effectiveness of exercises aimed at strengthening these muscles in children with pes planovalgus. therefore, the purpose of this study is to compare the effects of two corrective exercise programs focused on the improvement of the medial longitudinal arch in children with pes planovalgus: one incorporating routine intrinsic muscle exercises and the other combining them with extrinsic muscle exercises.

voluntary children who have been diagnosed with pes planovalgus will be included in the study. signed voluntary consent will be obtained from caregivers. participants will be divided into two groups. study groups will be as follows: a) intervention group (intrinsic\&extrinsic exercise), b) control group (intrinsic exercise).

Eligibility criteria:
inclusion criteria: * presence of bilateral pes planovalgus, * being between 4-7 years of age, * having a body mass index within normal limits exclusion criteria: * having high femoral anteversion, internal tibial torsion and metatarsus adductus * having leg length inequality * having any neurological, rheumatic, musculoskeletal, metabolic and connective tissue disease * having a history of pain, deformity or surgery related to the vertebral column and lower extremities * having a cognitive, mental or serious psychiatric disease * having been involved in any exercise program or sports activity in the last six months

Keywords: intrinsic foot muscle physiotherapy foot core flat foot extinsic foot muscle
registry of hypogonadism in men

Conditions: Male Hypogonadism; Androgen Deficiency; Testosterone Deficiency

Summary: the primary objective of the registry of hypogonadism in men (rhyme) is to establish and maintain a large, multi-national prospective registry of male patients who have been diagnosed with male hypogonadism (hg), also known as androgen deficiency or testosterone deficiency.


Eligibility criteria:
inclusion criteria: 1. male patients aged 18 years and older. 2. diagnosis of hypogonadism including klinefelter's or late onset hg. patients may have been diagnosed at any point in their lives. documentation of the diagnosis of hg (including symptomatology and laboratory values including testosterone levels confirmed on two separate occasions) is required. 3. written informed consent. exclusion criteria: 1. any previous treatment with testosterone therapy. 2. history of breast cancer, prostate cancer, or high-grade prostatic intraepithelial neoplasia. 3. prior radical prostatectomy. 4. life expectancy shorter than 24 months as judged by the clinical site investigator. 5. current major psychiatric disorders or drug or alcohol abuse, which will likely affect participation or compliance in the registry, in the opinion of the clinical site investigator. 6. gender dysphoria or sexual reassignment (e.g., transexualism). 7. patients actively enrolled in any interventional clinical trial. 8. planned relocation outside clinical site region within 24 months.

Keywords: registry natural history
wiser after ovarian cancer - exercise pilot study

Conditions: Ovarian Cancer

Summary: one in four deaths in the united states is due to cancer, and one in three women will develop cancer in her lifetime. despite improvements in survival among other forms of cancer, ovarian cancer prognosis remains poor. eighty percent of women with ovarian cancer will present with advanced disease (stage 3 or 4) where 5-year survival ranges from 18-34%.2 among patients with stage iii and iv epithelial ovarian cancer (eoc), recurrence rates are high.4 therefore, interventions focused on preventing recurrence or slowing progression of eoc is a critical problem in the field. the investigators have submitted an r21 to nci for a dose response exercise intervention trial to examine the dose response effects of aerobic exercise on biomarkers relevant to ovarian cancer progression and recurrence. the reviewers would like assurance that the investigators can recruit ovarian cancer patients into an exercise study and that these women will do the exercise protocol we plan to prescribe in our high dose of exercise.


Eligibility criteria:
inclusion criteria: * diagnosis of stage iii-iv eoc, completed surgery, * \> 12 months life expectancy (physician estimate), * able to walk 15 minutes at a time (use of a cane is acceptable). exclusion criteria: * medical or psychiatric conditions (beyond ovarian cancer, its treatment, and its symptoms) that would impair our ability to test study hypotheses (e.g. cardiac, pulmonary, or * orthopedic history that would prohibit a program of walking for exercise; * psychotic disorders, * dementia, * inability to give informed consent
the clinical study of shr-7631 for injection in patients with advanced solid tumors

Conditions: Advanced Solid Tumors

Summary: this study is an open-label, phase i clinical trial of shr-7631 in patients with advanced solid tumors. the whole study is divided into three stages: dose escalation, dose expansion and efficacy expansion.


Eligibility criteria:
inclusion criteria: 1. patients with histologically or cytologically confirmed unresectable locally advanced or metastatic solid tumors which is relapsed or refractory to standard treatment, or lack of standard treatment, or standard treatment is not applicable currently; 2. have at least one measurable tumor lesion per recist v1.1 (subject with only non-target tumor lesion will be permitted if he/she is planned to participant in dose escalation stage or with mcrpc); 3. ecog performance status of 0-1; 4. life expectancy ≥ 12 weeks; 5. adequate bone marrow and organ function 6. subjects must voluntarily agree to participate in the trial and sign a written informed consent form. 7. age 18 to 75 years old (including both ends), gender is not limited; exclusion criteria: 1. patients with active central nervous system metastases or meningeal metastases; 2. ongoing or previous anti-tumor therapies within 4 weeks prior to the first dose of study drug; 3. prior treatment with antibody-drug conjugate (adc) consisting of topoisomerase i inhibitors; 4. history of serious cardiovascular and cerebrovascular diseases; 5. severe infection within 4 weeks prior to the first dose; 6. adverse reactions of previous anti-tumor treatment have not recovered to grade ≤ 1 per nci-ctcae v5.0.
functional endoscopic sinus surgery study

Conditions: Chronic Rhinosinusitis (Diagnosis)

Summary: the aim of this study is to evaluate the effect of the addition of epinephrine to bilateral real time ultrasound guided pterygopalatine ganglion blocks on intra-operative bleeding and blood loss during functional endoscopic sinus surgery (fess).

fess is the treatment of choice in patients with medically refractory chronic rhinosinusitis and chronic polypous rhinosinusitis. this surgery relies on minimal surgical site bleeding to be performed efficiently and safely. hemorrhage during fess decreases visibility of the surgical field and this increases the risk of vascular, orbital and intracranial complications as well as procedural failure. thus the importance of minimizing surgical bleeding in this procedure. the maxillary artery is the primary blood supply for the sinuses and midface. conceptually the application of epinephrine into the pterygopalatine fossa onto the maxillary artery with the block should result in constriction of this artery and subsequently, less bleeding from the surgical site. this randomized, double-blinded, controlled pilot study will investigate the utility of addition of epinephrine to bilateral pterygopalatine ganglion blocks performed under ultrasound guidance in minimizing surgical site bleeding and overall blood loss and the potential for shortening the surgical time.

Eligibility criteria:
inclusion criteria: 1. patient presenting for bilateral fess 2. adult patients (\>18 and \< 90 years old) 3. patient consents to participate 4. no underlying chronic pain condition 5. no underlying bleeding diathesis exclusion criteria: 1. patient refuses to consent 2. patient requires revision or unilateral surgery 3. patient requires surgery in addition to fess 4. age younger than 18 or older than 90 years 5. any underlying chronic pain condition 6. history of bleeding diathesis 7. presence of any other factor which, at the discretion of any member of the study team, makes the patient a poor candidate for block placement. 8. presence of any other factor which, at the discretion of any member of the study team, makes the patient a poor candidate for research participation. 9. vulnerable patient population
social relations training for children with asd

Conditions: Autism; Autism Spectrum Disorder

Summary: the following protocol was developed with the intention of significantly improving social skills by focusing on increasing relationship skills among children with asd. divided into two distinct parts, "basic social relationships" and "intermediate social relationships," the protocol has 4 stages for the former and 5 stages for the latter. each phase is preparatory to the next, and in addition, a teaching procedure is implemented that adopts three prompt levels (partial, moderate and total), gradually aiming to reduce the assistance provided to encourage independent response. this gradual approach is designed to stimulate greater independence in social interactions. the training lasts between 6 and 12 months, with one or two weekly group meetings lasting forty-five minutes each. before the start and at the end of the protocol, participants are assessed using the vineland scale to evaluate their adaptive behaviors. the primary goal is to enable children with autism to develop meaningful social skills, providing them with concrete tools to interact more effectively and independently with their peers, thus improving their quality of life and social involvement. the protocol involves two distinct groups, experimental and control group. the experimental group involves the use of a social robot that acts as a mediator in the interactions among participants. the role of the social robot is to facilitate, reinforce and support the participants' responses during the activities. the therapist coordinates with the social robot, helping to guide, reinforce and support participants' interactions. in the control group, the therapist takes on the role of mediating interactions, helping and facilitating participants' responses. there is no involvement of a social robot; therefore,the therapist self acts directly to guide, reinforce and support the participants' social interactions.


Eligibility criteria:
inclusion criteria: * language in sentences * griffiths: qs\>75 exclusion criteria: * presence of other medical disorders

Keywords: autism children social relations social robot nao
tace plus tegafur versus tace for intrahepatic cholangiocarcinoma after curative resection

Conditions: Intrahepatic Cholangiocarcinoma

Summary: the aim of this study is to compare the outcomes of transarterial chemoembolization (tace) plus tegafur with tace alone in patients with intrahepatic cholangiocarcinoma after curative resection


Eligibility criteria:
inclusion criteria: * male or female patients \> 18 years and \<=70 years of age. * pathological evidence of icc * tumors can be completely resected. * criteria of liver function: child a-b level, serum bilirubin ≤ 1.5 times the upper limit of normal value, alanine aminotransferase and aspartate aminotransferase ≤ 2 times the upper limit of normal value. * patients who can understand this trial and have signed information consent. exclusion criteria: * tumors can not be resected . * patients with apparent cardiac, pulmonary, cerebral and renal dysfunction, which may affect the treatment of intrahepatic cholangiocarcinoma. * patients with a medical history of other malignant tumors. * subjects participating in other clinical trials. * liver function:child c.

Keywords: chemoembolization therapeutic tegafur
intraoral injection of trigger points by botox

Conditions: Myofacial Pain

Summary: patients with orofacial pain lasting at least 3 months. the patients will be randomly assigned to one of the two groups according to the treatment method: group i (intraoral injection) and group ii (transcutaneous injection) where each patient injected botox at each trigger point according to the treatment group by the same operator. patients will be examined by a blinded investigator at pre- and post-injections at the following intervals: during diagnosis, 1 week, 4, and 6 weeks post-injection. the patients will be assessed using a pain score measured on a 10-point visual analog scale (vas). the secondary outcome assessed will be measuring the quality of life in an oral health impact profile questionnaire (ohip-14).


Eligibility criteria:
inclusion criteria: * definite diagnosis of myofascial pain with a referral * the presence of one or more trigger points in the unilateral or bilateral masseter muscle - * no history of any invasive procedures in the related masseter muscle exclusion criteria: * factors that can cause pain in the orofacial region other than trigger points (decayed tooth, temporomandibular joint internal disorder). * any systemic disease that possibly affects the masticatory system such as rheumatoid arthritis and epilepsy * pregnancy and lactation.
study in healthy volunteers to assess effect of omeprazole and ranitidine on the pharmacokinetics of vandetanib

Conditions: Medullary Thyroid Cancer

Summary: study in healthy volunteers to assess effect of omeprazole and ranitidine on the pharmacokinetics of vandetanib

a phase i, randomized, open-label, single-center study to assess the pharmacokinetics of vandetanib (caprelsa) in healthy subjects when a single oral dose of vandetanib 300 mg is administered alone and in combination with omeprazole or ranitidine

Eligibility criteria:
inclusion criteria: * provision of signed and dated, written informed consent prior to any study-specific procedures * volunteers must be males or females aged 18 to 50 years and with a weight of at least 50 kg and body mass index (bmi) between 18 and 30 kg/m2 * inclusive females must have a negative pregnancy test at screening and on admission to the study center * females must not be lactating and must be of non childbearing potential defined as postmenopausal or documentation of irreversible surgical sterilization. exclusion criteria: * history of any clinically significant disease or disorder such as gastrointestinal, hepatic, renal or skin disease. * history of severe allergy/hypersensitivity or ongoing allergy/hypersensitivity * volunteers who smoke more than 5 cigarettes per day or are unable to refrain from smoking while resident in the study center * screening blood pressure of greater than 140/90 mmhg and/or a resting heart rate of less than 45 beats per minute (repeat test allowed at the investigator's discretion * clinically significant abnormal12-lead ecg as assessed by the investigator * qtcf interval greater than 450 ms any positive result on screening for serum hepatitis b surface antigen, hepatitis c antibody * human immunodeficiency virus (hiv), or positive screen for drugs of abuse.

Keywords: phase 1 healthy volunteers pharmacokinetics vandetanib omeprazole ranitidine
the spine kinematics and center of pressure excursion during functional task vertebral compression fractures subjects

Conditions: Posture; Vertebral Compression Fracture

Summary: this study aimed to assess the sensory and kinematic components of the limits of stability (los) test in patients with vertebral compression fracture (vcf) .

this study enrolled adults with vcf (vcf group), older adult without spinal deformity (ne group), and young adults (ny group). the biodex balance system was employed to calculate the balance score and the los of participants. an inertia motion system was used to record kinematic data. the center of pressure (cop) signals of postural stability and los were used to calculate the frequency power spectrum for interpreting the sensory component.

Eligibility criteria:
vertebral compression fracture inclusion criteria: older than 65 years osteoporosis diagnosed by a bone mineral density test of the lumbar spine (t-score \< -2.5; t: peak bone mass) thoracic-lumbar vcf on radiography without displacement vertebral compression fracture exclusion criteria: other spinal diseases that might also cause back pain (such as scoliosis, lumbar spondylolisthesis, lumbar disk disease, and spinal stenosis) a history of diabetes a history of neurological disease (such as cerebral vascular disease, peripheral neuropathy and vestibular disease). control inclusion criteria: none the control participants had evidence of gait, postural, or spine disorders.
return to work after total knee arthroplasty in young patients

Conditions: Knee Arthritis

Summary: this study takes its base in the augmenting number of primary total knee arthroplasty in the world whom quality and survey had permit to widen their indications to younger patients who are in the age of professional activity. this work will focus on young patients under 55 who had had primary total knee arthroplasty, retrospectively, over the past 10 years, to determine the factors influencing early or late return to work, depending of socio economics factors. this will optimize the information for the patient, and prepare him if necessary for a long work stop, and possibly obtain a better satisfaction for him.

the primary aim of this study is to determine the rate of young patients returning to work after a primary total knee arthroplasty and the mean delay, and to compare it to other studies. the mean delay of return to work in the literature is between 8 to 12 weeks, with up to 98% of patients returning to work. the investigators will next determine which category of patients could have a late return to work superior to 6 months, and also if the surgery could give back a professional activity to patients who were in a long work stoppage.

Eligibility criteria:
inclusion criteria: * first intention total knee arthroplasty * age at the time of surgery under 55 exclusion criteria: * not in capacity of completing a questionnaire * revision of total knee arthroplasty

Keywords: total knee arthroplasty return to work arthroplasty
extracorporeal photopheresis for acute graft versus host disease

Conditions: Graft Versus Host Disease; Cancer; Stem Cell Transplantation

Summary: the purpose of this research study is to evaluate the safety and feasibility of extracorporeal photopheresis (ecp) in the treatment of steroid-refractory acute graft-versus-host disease (gvhd) in children.


Eligibility criteria:
inclusion criteria: * status-post allogeneic stem cell transplant (includes cord blood transplant, matched-unrelated-donor transplant and matched-related donor transplant) for any indication. * hla matching needs to be 4-6/6 by at least intermediate resolution for class i + ii for cord blood and 5-6/6 for matched related or matched unrelated donors. * diagnosis of grade ii-iv acute gvhd with histological confirmation of at least one organ (skin, gut, or liver) within the last 14 days. grading of acute gvhd is per the standard keystone criteria. prior to enrollment, efforts should be made to rule out diagnoses that may mimic gvhd, such as drug rashes or gi infection. patients that are being treated for acute gvhd and appear to be progressing to chronic gvhd are also eligible * no improvement, or worsening, of acute gvhd after at least 4 days of iv methylprednisolone dosed at, at least 2.0mg/kg/day.. * weight \>25.0kg. * adequate venous access. exclusion criteria: * evidence of veno-occlusive disease. * intubated patient. * patient receiving dialysis. * age \> 30. * total bilirubin \>15mg/dl

Keywords: graft versus host disease ecp extracorporeal photopheresis allogeneic transplantation
pilot examination of a telehealth, cognitive-behavioral therapy for adolescents

Conditions: Suicide Prevention; Suicidal Ideation

Summary: this project is designed to refine a 6-week telehealth therapy intervention targeting negative interpersonal beliefs among community-dwelling youth with elevated levels of psychopathology. the study design is a single-arm open trial. the intervention is comprised of weekly teen and parent group cognitive-behavioral therapy, regular check-ins with the youths, and a module embedded throughout treatment that targets negative interpersonal beliefs (i.e., perceived social disconnection, burdensomeness). the goal of the study is to evaluate the feasibility of the treatment and assessment protocol, refine the intervention based on qualitative feedback, and evaluate changes in negative interpersonal beliefs. youths complete two qualitative interviews about their interpersonal relationships and their feedback about the intervention.


Eligibility criteria:
inclusion criteria: * 14-17 years of age * endorsement of perceived burdensomeness (score of greater than 3 on the interpersonal needs questionnaire) * emotional/behavioral problems broadly defined (pediatric symptom checklist score greater than 14) * the family being under-resourced (i.e., family is below the us census poverty line; family is receiving economic or medical government aid; child is receiving reduced fee lunch; or primary caregiver is currently unemployed) or living in an under-resourced community (i.e., majority of households in the family's census block lives under the poverty line). exclusion criteria: * current need for acute psychiatric care (e.g., inpatient hospitalization) * autism spectrum disorder * psychosis * other condition(s) related to pronounced cognitive impairment (i.e., marked impairment that precludes completion of questionnaires, verbal communication) * wards of the state