Kornimate/medical-research-clean huggingface dataset:
a study to assess the potential impact of disease modifying therapies on covid-19 outcomes and the antibody response following an infection with sars-cov-2 in patients with multiple sclerosis within the swiss multiple sclerosis cohort.

Conditions: Multiple Sclerosis; COVID-19 (Severe Coronavirus Disease 2019)

Summary: this nested project of the swiss multiple sclerosis cohort (smsc) is to assess the severity of covid-19 and the magnitude of antibody response after infection with severe acute respiratory syndrome coronavirus 2 (sars-cov-2) in patients already treated or not with various immunotherapies for multiple sclerosis followed in the framework of the smsc.

this nested project of the swiss multiple sclerosis cohort (smsc) is to assess the severity of covid-19 and the magnitude of antibody response after infection with severe acute respiratory syndrome coronavirus 2 (sars-cov-2) in patients already treated or not with various immunotherapies for multiple sclerosis followed in the framework of the smsc. to assess the frequency and severity of sars-cov-2 infections and associated symptoms in the study population, data is collected from systematic questioning during the smsc-visits and from serum samples collected every 6-12 months within the smsc (for measurement of anti-sars-cov-2 antibodies in pre-pandemic reference samples and prospectively to determine the anti-sars-cov-2-serostatus during the study period). combining the information on anti-sars- cov-2 serostatus and infection history opens the opportunity to determine the number of patients without or with only mild vs. moderate to severe covid-19 symptoms in large groups of patients with multiple sclerosis (ms) treated with immunotherapies targeting various components of the immune system.

Eligibility criteria:
inclusion criteria: * all patients in the swiss multiple sclerosis cohort (smsc) exclusion criteria: * patients with neuromyelitis optica and radiologically isolated syndrome will be excluded * existence of a documented refusal of further use of health-related personal data and/or biological material

Keywords: severe acute respiratory syndrome coronavirus 2 (sars-cov-2) swiss multiple sclerosis cohort (smsc)
comparison of single versus multicenter outcomes for pelvic organ prolapse repair using a mesh-capturing device

Conditions: Prolapse Genital

Summary: comparison of single versus multicenter outcomes for pelvic organ prolapse repair using a mesh-capturing device (the uphold™ vaginal support system for apical and vaginal wall prolapse - boston scientific). 1-2 years follow up study comprison of 112 vs 207 patients.

112 women operated by two surgeons at one center (2 years follow up) are to be compared to 207 women operated by twenty six surgeons at twenty four centers (1 year follow-up). screening at baseline for apical (uterine or vaginal vault) prolapse stage ii with or without concomitant anterior or vaginal wall prolapse ≥ stage 2 according to the pelvic organ prolapse quantification (pop-q) system. surgical data including operation data, complications and hospital stay are to be compared. anatomical outcome measurements by pop-q evaluations. subjective symptoms are to be evaluated by prolapse specific symptom questionnaires (pfiq-7, udi-6 and pfiq) whereas sexual function to be estimated by pisq-12.

Eligibility criteria:
inclusion * posthysterectomy prolapse of the vaginal apex, with or without cystocele, where the vaginal apex descends at least 50% of the total vaginal length * uterine prolapse, with or without cystocele, where the leading edge of the cervix descends at least 50% of the total vaginal length and tvl minus point c= ≤ 2 cm * prolapse specific pelvic symptom of pelvic heaviness and/or vaginal bulging * reproductive years in the past (biologically or reproductive decision) * being able to make an informed consent on participation * physically and cognitively capable of participating in the required follow-up * no exclusion criteria fulfilled exclusion criteria: * posthysterectomy prolapse of the vaginal apex where the vaginal apex descends less than 50% of the total vaginal length regardless of whether a cystocele is present or not * uterine prolapse, with or without cystocele, where the leading edge of the cervix descends less than 50% of the total vaginal length * if cervix elongation is present corresponding to: tvl minus point c= \>2 cm. * if prolapse specific pelvic symptoms of pelvic heaviness and/or vaginal bulging are not present * previous or current pelvic organ cancer (regardless of treatment) * severe rheumatic disease * insulin treated diabetes mellitus * connective tissue disorders (sle, sjögrens syndrome, marfans syndrome, ehlers dahnlos, collagenosis, polymyositis eller rheumatic myalgia) * current systemic steroid treatment * other clinically relevant pelvic disorders for which surgery is indicated including stress urinary incontinence, cervix elongation and posterior prolapse * decision to perform prolapse surgery using other medical devices/mesh

Keywords: pelvic organ prolapse transvaginal mesh complications
progressive resisted exercise plus aerobic exercise on osteoporotic systemic lupus erythmatosus

Conditions: Systemic Lupus Erythematosus

Summary: systemic lupus erythematosus (sle) is the most common autoimmune disease in women of childbearing age. promoting physical activity is a major national priority for the general population, including patients with chronic diseases. the aim of this study is to investigate the efficiency of combined effect of progressive resisted exercise with aerobic exercise for bone mineral density, quality of life, muscle strength and physical activity for patients with sle.

the following factors were found to be significantly related to lower bmd by univariate analysis: caucasian race, older age at diagnosis, higher age at the time of the first dxa, longer disease duration, higher cumulative corticosteroid dose, lower serum levels of 25(oh)d, higher sle damage index score, and postmenopausal status. in the multivariate analysis only the following factors were significant: caucasian race, increased number of pregnancies, postmenopausal status, higher sle damage index, and higher cumulative corticosteroid dose. as the quality of life among patients with sle not fully associated with sle disease activity, pharmacologic treatments that are effective for sle disease activity might not be able to improve quality of life in these patients therefore, the beneﬁt of nonpharmacological therapies on quality of life has been explored.

Eligibility criteria:
inclusion criteria: * diagnosis of systemic lupus erythematosus by the classification criteria acra and the 2019 eularb/acr classification criteria for systemic lupus erythematosus * systemic lupus erythematosus disease activity index ≥4 * for 30 day prior, stable immunosuppressive therapy with steroid (0-20 mg/day) or other immunosuppressive medication such as hydroxychloroquine, chloroquine, azathioprine, methotrexate, mycophenolate mofetil, cyclosporine, belimumab, rituximab exclusion criteria: * those who are pregnant. * patients with active lupus nephritis, cardiovascular dysfunction, rhythm and conduction disorders. * patients with musculoskeletal disturbances; kidney and pulmonary involvements; peripheral neuropathy and fibromyalgia. * use of tobacco; treatment with lipid-lowering, chronotropic or antihypertensive drugs

Keywords: progressive resisted exercise aerobic exercise osteoporosis systemic lupus erythmatosus
ultra-high resolution optical coherence tomography in detecting micrometer sized early stage pancreatic cancer in participants with pancreatic cancer

Conditions: Pancreatic Carcinoma; Pancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatobiliary-Type

Summary: this trial studies how well ultra-high resolution optical coherence tomography works in detecting micrometer sized early stage pancreatic cancer in participants with pancreatic cancer. ultra-high resolution optical coherence tomography may help to accurately identify pancreatic cancer in resected pancreatic specimens.

primary objectives: i. to evaluate the using of optical coherence tomography (oct) to diagnose pancreatic cancer arising in the setting of intraductal papillary mucinous neoplasms (ipmn) using the resected pancreatic specimen. ii. to correlate oct imaging diagnosis with histologic findings in the human pancreatic duct. ipmn is a premalignant lesions arising in the pancreas. typically, ipmns are identified incidentally on imaging performed for other reason or related to vague abdominal pain or gastrointestinal complaints. in terms of ipmn, invasive cancer can be found in this setting between 20 to 50% of the time\[7\] therefore, if a patient is diagnosed with ipmn, especially main duct type, the general recommendation is to undergo resection. we propose to assess the duct of the pancreatic specimen after resection to identify evidence of invasive malignancy by oct imaging. afterwards, the specimen will be undergoing histopathologic assessment using standard protocols. our hypothesis is that oct will accurately identify pancreatic cancer in resected pancreatic specimen. the assessment with oct is non-invasive and will not harm to change the specimen prior to going to pathology for standard review. future studies will then focus on using this imaging technique in vivo to endoscopically identify early stage pancreatic cancer.

Eligibility criteria:
inclusion criteria: * immediate surgery cohort: adult patients with pancreatic cancer or ipmn * immediate surgery cohort: informed consent will be obtained * adult patients undergoing pancreatic resection for a presumed ipmn exclusion criteria: * pregnant
evaluation of a primary prevention program for anxiety disorders using story books

Conditions: Anxiety

Summary: the purpose of this study is to assess the impact of a primary prevention program for anxiety disorders. this study was completed between 2000 and 2002, with the final report transmitted to the quebec ministry of health in 2003.

this study reports the results of a study evaluating a book-supported prevention program "dominique's handy tricks" for anxiety disorders in children aged 9 to 12 years of age. this cognitive-behavioural program is delivered using a combination of story-based books and workshop sessions. the originality of the program comes from the use of story books that were not developed for anxiety management specifically. every session is based on a story describing characters facing common stressors in childhood and how they managed to cope with their daily problems. in our randomized control trial with 46 children, participation in the program lead to a significant improvement in coping skills, self-efficacy, anxiety sensitivity, signs of anxiety and phobic avoidance. the theoretical and practical elements underlying the delivery of this primary prevention programs are described. it is suggested that such an approach, without any labelling specific to anxiety disorders, can be useful in universal primary prevention programs.

Eligibility criteria:
inclusion criteria: * recruitment for this study was open to every child in the school and was carried out with the help of staff from schools in gatineau and saint-andré avelin, quebec. * a total of 73 children aged between 9 and 12 years of age were screened. exclusion criteria: since the program does not target a clinical population, the following exclusion criteria were used: * (1) a global score \> 75 on the child behavior checklist; * (2) a score \> 60 on the screen for child anxiety related emotional disorders (scared, child version); * (3) outliers on outcome measures administered at pre-test; and * (4) children who did not show up for the first workshop. the final enrolled study sample consisted of 59 children.

Keywords: no condition primary prevention anxiety
evaluate the frequency of fatigue after cerebral infarction

Conditions: Symptomatic Cerebral Infarction

Summary: cerebral infarction is a type of stroke that can lead to sometimes disabling sequelae. among these sequelae, fatigue is frequently reported by patients. it is therefore important for doctors to understand why patients suffer from fatigue after cerebral infarction and to determine whether treatments given for the cerebral infarction may have an impact on this fatigue. the aim of this research was to study the frequency of fatigue after cerebral infarction, the associated factors, in particular the impact of treatments administered in the acute phase.


Eligibility criteria:
inclusion criteria: * patients presenting recent symptomatic cerebral infarction (\< 1 week) defined according to world health organization (who) criteria and hospitalised at the stroke unit in dijon university. * patients aged 18 years or older. * patients who have been informed about the study, or their person of trust for patients unable to express their consent. exclusion criteria: * patients (or their person of trust) who refuse to participate in the study. * subjects in custody. * patients presenting prior co-morbidity as a cause of significant fatigue in the opinion of the investigator * patients with dementia or aphasia before the stroke * patients (or their person of trust) who may be difficult to contact by telephone during the follow-up.
evaluation of long-term safety and efficacy of elx/tez/iva tc combination therapy in participants with cystic fibrosis who are 6 years of age and older

Conditions: Cystic Fibrosis

Summary: the study evaluates the long-term safety, tolerability, efficacy, and pharmacodynamics of elexacaftor (elx, vx-445) in triple combination (tc) with tezacaftor (tez) and ivacaftor (iva) in participants with cystic fibrosis (cf).


Eligibility criteria:
key inclusion criteria: * completed study drug treatment in parent study (vx18-445-106 part b, nct03691779), or had study drug interruption(s) in parent study but completed study visits up to the last scheduled visit of the treatment period in the parent study key exclusion criteria: * history of study drug intolerance in parent study other protocol defined inclusion/exclusion criteria may apply.
effects of virtual discrete trial training on children with autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: autism spectrum disorder (asd) is a neurodevelopmental disorder categorized by deficits in social communication and the occurrence of restricted interests and repetitive behaviors. the cautionary needs of children with asd are significant, it affects parents and siblings as well and requires substantial social support. if adequate intervention is not provided to children with asd on time, then they may face many difficulties for example in academic work. they face social isolation and may develop additional challenging behaviors. applied behavior analysis (aba) is one of the most commonly used supported treatments for autism spectrum disorder. discrete trial training (dtt) is one of the most structured applied behavior analysis (aba) types. dtt is the best standardized therapy for asd. the aba explores human interactions with their environment over time and develops interventional strategies to diminish the decline in the troublesomeness of social behavior among individuals with asd. dtt through video training program will be an effective in improving the communication skills of children with asd. the video training program offers excellent accessibility and is inexpensive because it can be administered remotely and at home as well. it also reduces the resource barrios. a randomized controlled study was conducted on children aged between 3-10 years diagnosed with asd at psrd hospital having different severity levels. dtt was provided through a video training program using digital technology with informed consent from their caregivers/parents. the sample size was 10. both groups contain 5 participants. the treatment group will be trained on dtt through the video training program. sessions were conducted thrice a week for 45 minutes. the duration of the experiment was 12 weeks. the control group did not intervene with the video training program during the experiment. pre \& post language assessment was done through british picture vocabulary scale.


Eligibility criteria:
inclusion criteria: * age range between 3-10 years. * clinically diagnosed children from psychologists were taken for study who had 2-3 words in vocabulary or no vocabulary at all. * each group received 3 weekly sessions for 45 minutes for 12 weeks. * video training was given through animated videos. exclusion criteria: * children with any comorbidities e.g. intellectual disability, cerebral palsy, attention deficit hyperactive disorder, down's syndrome and hearing impaired children will exclude from this study. * children diagnosed with severe autism.
effects of telemonitoring in quality of life amongst cancer patients

Conditions: Cancer; Telemonitoring; Telemedicine; Symptoms and Signs; Quality of Life

Summary: this interventional study aims to explore the potential of a smartphone app, contigo, in enhancing the quality of life for patients with various cancers compared to standard care. the investigators will asses effects on quality of life, depressive symptoms, and appointment adherence.

the primary objective of this study is to determine if utilizing a smartphone app for disease monitoring improves the self-reported quality of life using validated questionnaires in patients with diverse solid cancers compared to standard care. secondary objectives focused on evaluating its impact on depressive symptoms and assessing adherence to in-person appointments. this study involves a randomized trial among patients recently diagnosed with specific forms of cancer and undergoing curative treatment at the uc christus cancer center. the eligible participants, 80 adults with recent histologically confirmed cancer diagnoses, will be randomized to receive either the smartphone application (contigo) or standard educational care. randomization will be performed independently using an allocation sequence that will be kept concealed from clinical investigators. contigo offers two primary functions: monitoring cancer patients and delivering educational content to aid patients in dealing with common clinical situations related to their disease. the study will assess outcomes such as quality of life changes, depressive symptom development, and adherence to in-person appointments. all analyses will be undertaken under the intention to treat principle by a statistician unaware of treatment allocation.

Eligibility criteria:
inclusion criteria: * adult patients (\>18 years old). * recent histologically confirmed diagnosis (within the last 3 months) of bronchogenic, breast, gallbladder, gastric, colorectal, or prostate cancer in any of its forms. * awaiting initiation of curative intent treatment for the disease using any modality (radiation therapy, chemotherapy, immunotherapy, etc.) at the uc-christus cancer center. * possession of a smartphone, regardless of its native operating system (ios® or android®). * willingness to sign an informed consent form to participate in the study. exclusion criteria: * any form of sensory impairment preventing app usage. * cognitive impairment. * psychiatric pathology hindering app usage. * unwillingness to participate in the study. * concurrent participation in another clinical trial addressing healthcare technologies.

Keywords: telemonitoring internet web-based applications quality of life smartphones cancer
long-term safety and efficacy study of hsk44459 tablets in patients with idiopathic pulmonary fibrosis (ipf)

Conditions: Idiopathic Pulmonary Fibrosis (IPF)

Summary: this study is open to people with idiopathic pulmonary fibrosis (ipf) . they can only take part if they have completed treatment in a previous study with a medicine called hsk44459. the primary object of this study is to find out how well people with idiopathic pulmonary fibrosis (ipf) tolerate long- term treatment with hsk44459.


Eligibility criteria:
inclusion criteria: 1.ipf patients who completed the last dose treatment of hsk44459 in previous trials without prematurely discontinuing treatment permanently according to protocol , and have been evaluated by the researchers to have greater benefits than risks, and may benefit from continued treatment with hsk44459 exclusion criteria: 1. patient will plan to undergo lung transplantation. 2. patients with a body mass index (bmi) \ 10%) weight loss during the previous trials. 3. history of malignancy within 5 years prior to screening. 4. history of depression or anxiety disorder.
exploratory study of predictive markers of the therapeutic response in patients with chronic inflammatory demyelinating polyradiculoneuropathy treated with intravenous immunoglobulin

Conditions: Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Summary: chronic inflammatory demyelinating polyradiculoneuropathy (cidp) is an acquired neuropathy characterized by an inflammatory multifocal segmental demyelination. due to the clinical heterogeneity of this condition and the lack of specific marker that can reliably identify all patients, the diagnosis of cidp remains difficult. similarly, there are no clear factors predicting the evolution or the prognosis of the disease. current treatments are the intravenous immunoglobulin (ivig), corticoids and plasma exchange; ivig therapy being the most commonly used. responses of the patients to the treatments are variable. thus, it is necessary to identify predictive markers of the therapeutic response of cidp patients treated by ivig. several potential biomarkers have been proposed recently, but none of them has yet been validated as a predictive criterion for therapeutic response. it is therefore necessary to continue to investigate several biological parameters to identify a reliable biological marker. in electromyography, the motor unit number index (munix) technique allows measuring the axonal loss by a precise count of functional motor units. this method, more sensitive than the measure of the compound muscle action potential (cmap), is rarely used in cidp. munix might be a good tool to better characterize the patients and to follow the course of cidp. it also might be a new sensitive and reliable marker predictive of the therapeutic response. magnetic resonance imaging (mri) is increasingly used for the assessment of neuromuscular diseases. a recent study on cidp patients reported a significant decrease of the muscle magnetisation transfer ratio (mtr) compared to healthy subjects, correlated to clinical parameters. the use of advances mri techniques could allow characterizing the structure and composition of muscle and nerve tissues of cidp patients. it could also be a mean for identifying potential new markers, largely unexplored until now, that might be sensitive to disease course and/or ivig response. the objective of this study is to identify predictive markers of the treatment response of cidp patients receiving ivig. this is a prospective observational exploratory study of a cohort of 30 cidp patients treated with ivig and followed-up during one year.


Eligibility criteria:
inclusion criteria: * suffering from cidp * fulfilling the efns/pns (european federation of neurological societies / peripheral nerve society) 2010 revised criteria * treated with ivig or needed to be treated with ivig exclusion criteria: * patients with a known hypersensitivity to the normal human ig or one of the constituents of the preparation * patients with a known iga deficiency or with anti-iga circulating antibodies * patients with a change in their immunosuppressive or immunomodulatory treatment in the last 6 months * patients with a contraindication for mri explorations