Kornimate/medical-research-clean huggingface dataset:
video game for home-based rehabilitation for children with hemiplegia

Conditions: Child; Hemiplegic Cerebral Palsy

Summary: this study evaluates the feasibility of a low-cost, movement tracking video game (bootle blast) to 1) sustain engagement in children with cerebral palsy (cp) during a 12-week intervention; and 2) generate changes in upper limb functional motor outcomes following the intervention.

children with cerebral palsy (cp) can benefit from home-based practice of therapy exercises. however, sustaining engagement in home-based therapy is challenging. bootle blast is a low-cost video game that uses the microsoft kinect sensor to track upper limb movements and interactions with real-life objects (e.g. musical instruments, building blocks). to play bootle blast, the child needs to use the hemiplegic arm/hand to play unilateral game activities, and highly involve it in bilateral activities. this study will answer our research questions: 1) to what extent can children achieve a weekly play-time goal (ptg) over a 12-week intervention (adherence) when the ptg is family identified? 2) to what extent can the use of bootle blast lead to improvements in ul motor function? and 3) what are the participant's experiences of using bb for home rehabilitation? as measures of feasibility we hypothesize that 1a) 75% of children will achieve their weekly play time goal and complete the 12-week intervention and 2) 75% children who achieve their weekly play time goal will improve in one or more ul motor outcome measures.

Eligibility criteria:
inclusion criteria: * diagnosis of hemiplegic cerebral palsy, gross motor function classification system and manual abilities classification system levels i to iii, able to co-operate, understand and follow simple instructions for gameplay, live within 30 km of the holland bloorview kids rehabilitation hospital, having a caregiver willing to participate. exclusion criteria: * currently receiving active occupational or physical therapy that may impact motor function of the upper limb, botulinum toxin treatment within 3 months or constraint-induced movement therapy within 6 months of study enrollment, visual, cognitive or auditory limitations at a level that would interfere with gameplay, uncontrolled epilepsy or history of epilepsy related to video game play.

Keywords: video games upper extremity rehabilitation cerebral palsy
intervention nurses start infants growing on healthy trajectories (insight) - long term follow-up

Conditions: Child Obesity

Summary: intervention nurses start infants growing on healthy trajectories (insight 2)-long term follow-up will follow participants enrolled in the intervention nurses start infants growing on healthy trajectories (insight) (nct01167270) study from age 3 years through the developmentally important time at school-entry around age 6 years and into middle childhood at age 9.

insight(nct01167270) is a randomized, clinical trial evaluating a responsive parenting (rp) intervention designed to prevent rapid infant weight gain and childhood obesity among first-born infants. rp has been shown to promote a range of adaptive outcomes in children including secure attachment, cognitive development, and self-regulation of emotions and behavior with the potential for many beneficial effects including obesity prevention. insight's rp intervention is being compared with a home safety control intervention using a birth cohort of 279 infants and parents who received four home visits during the first year followed by annual clinic visits through age 3 years. the study team will now follow the insight cohort with growth measurements from ages 5-9 years and with an in-depth assessment of parenting and child behaviors around the time of grade school entry at age 6. the study extension is observational and participants will not be given any further parenting or safety guidance as described in the initial grant.

Eligibility criteria:
inclusion criteria: * participating in the insight study. exclusion criteria: * unwilling to continue study participation for the study continuation.

Keywords: responsive parenting
effects of prosthesis training on pain, prosthesis satisfaction and ambulatory status of lower limb amputees

Conditions: Lower Limb Amputation Below Knee (Injury)

Summary: the objective of the study is to assess the effects of prosthesis training with and without phantom exercises on pain, prosthesis satisfaction and ambulatory status of lower limb amputees treated with prosthesis training, phantom exercises and routine physical therapy.

amputation is a catastrophic incident in a person's life which resulted in psychological, social and physical consequences. loss of extremity resulted in negative impact on patient's body and perception as well. phantom limb pain (plp) can be defined by discomfort or pain in lost part of limb experienced by lower limb amputees. phantom limb pain is physically and mentally draining condition which affects patient's daily activities like personal care and functional independence. phantom limb pain is highly prevalent condition among lower limb amputees. it is associated with negative effect on mental and physical health conditions. there are studies conducted on prosthesis training for prosthesis satisfaction. however, according to researcher knowledge effects of prosthesis training along with phantom exercises have not been measured on prosthesis satisfaction. this study will encourage future studies on this topic and will help in developing state of art treatment of phantom limb discomfort associated with lower limb subtraction. as managing phantom discomfort can result in better prosthesis satisfaction and eventually ease the ambulatory status of patient.

Eligibility criteria:
inclusion criteria: 1. age: 18-60 years 2. gender: male/female 3. unilateral lower limb amputees (trans-femoral, trans-tibial) and using prosthesis and having phantom limb pain will be included. 4. limb deficiency and phantom limb questionnaire was used for screening of patients exclusion criteria: 1. severe systematic illness 2. psychological issues 3. hearing/ visual impairment 4. malignancies 5. infectious disease 6. neuropathic pain except plp and residual limb pain 7. any disorder that restricts movement of opposed limb, limited range of motion in sound limb 8. taking pain relief medications

Keywords: phantom limb pain prosthesis prosthesis training prosthesis satisfaction
evaluation of the medical service by socio-aesthetics in oncology

Conditions: Cancer of Colon; Cancer, Lung; Cancer, Breast; Cancer Prostate; Cancer Pain; Anxiety Depression

Summary: the 3-year randomized controlled rct-se study aims to investigate socio-aesthetics well being care on quality of life, pain and anxiety. the primary objective is to show that socio-aesthetics well being care improves quality of life during cancer treatment, compared to self care administration of dermo-cosmetics products the secondary objectives are to show that socio-aesthetics well being care significantly reduced anxiety and pain compared to self care administration of dermo-cosmetics products

socio-aesthetics care is the delivery appropriate beauty care in a population weakened by a physical, psychological and/or social attack. this well-being care is imperfectly assessed with few data from randomized controlled trials. the rct-study is a randomized, controlled, multicenter, open label, intervention study that will be conducted among 400 patients treated with chemotherapy for breast, prostate, colon and lung cancer. patients will be randomly assigned to one of the two arms of the study according to a 1:1 ratio: * group a will benefit from 4 sessions of well being care performed by a qualified socio-aesthetic person, with dermo-cosmetics product defined, during 4 consecutive chemotherapy administrations . * group b (control) will apply the same dermo-cosmetics products themselves (self-care) without intervention of socio-aesthetic, during 4 consecutive chemotherapy administrations 12 evaluations will be conducted between chemotherapy cure n° 2 and chemotherapy cure n°5: * pain assessed by eva * anxiety assessed by hads * impact of socio-aesthetics care care , assessed by patient centricity questionnaire (pcq) (0 -110) data will be recorded using an e-crf. patient will be recruited over 3 years and will be followed up for 3 months. hypothesis: socio-aesthetics session significantly improves quality of life and reduced pain and anxiety compared to self care administration of dermo-cosmetics products

Eligibility criteria:
inclusion criteria: * over 18 years old * treated with chemotherapy for lung , breast, colon or prostate cancer * able to understand, read, and write french, * affiliated with a social security scheme, * having dated and signed an informed consent. exclusion criteria: * unable to be followed for medical, social, family, geographic or psychological reasons for the duration of the study, * deprived of their liberty by court or administrative decision,

Keywords: socio-aesthetic
effect of intraoperative infiltration with bupivacain on the development of chronic pain after inguinal hernia repair

Conditions: Chronic Pain

Summary: the effect of intraoperative infiltration of the operation site with bupivacain on the development of chronic pain is the object of our trial. we hypothesize that the occurrence of chronic pain in the goup of patients receiving the infiltration will be 50% less than in the placebo group receiving normal saline. the study is a randomized controlled triple blinded trial with a sequential study design.

264 patients scheduled for an inguinal hernia repair using one of three procedures (lichtenstein, barwell and tep = total extraperitoneal hernioplasty) are being randomly allocated intra-operatively into two groups. group i patients receive a local injection of 20ml carbostesin® 0.25% at the end of the operation according to a standardised procedure. group ii patients get a 20 ml placebo (0.9% saline) injection. we use pre-filled identically looking syringes for blinded injection, i.e. the patient, the surgeon and the examinator who performs the postoperative clinical follow-ups remain unaware of group allocation. the primary outcome of the study is the occurrence of developing chronic pain (defined as persistent pain at 3 months fu) measured by vas and pain matcher® device (cefar medical ab, lund, sweden). in addition to a sample size re-evaluation three interim analyses are planned after 120, 180 and 240 patients had finished their 3-months follow-up to allow for early study termination.

Eligibility criteria:
inclusion criteria: * adult patients (≥ 18 years) with primary or recurrent single or double sided symptomatic but not incarcerated inguinal hernias with an elective hernia repair are included. * no other interventions (i.e. umbilical hernia) are allowed. * written informed consent needs to be obtained. exclusion criteria: * patients with legal incompetence, * pregnant and nursing women, * patients with presence or history of active malignancy or systemic diseases, * under immunosuppressive treatment, * with systemic or severe local inflammation or infection, * with wound healing disorders and with physical or mental incapacity, which makes it impossible to obtain informed consent are excluded. * as pacemakers interfere with the electrical stimulation of the pain matcher® and vice versa patients with pacemakers or other implanted electrical devices were also excluded.
the collaborative care prtner study

Conditions: HIV; Substance Use Disorders; Substance Use; AIDS

Summary: a randomized controlled trial to assess the ability of a collaborative care prevention, treatment, navigation, engagement, resource (prtner) intervention to increase initiation of preexposure prophylaxis (prep) (for those at-risk for hiv) and decrease viral load (for those living with hiv) among young black and latino men who have sex with men (yblmsm) aged 15 to 24 through engagement in su treatment.

the collaborative care (cc) prtner is a multi-component intervention developed by members of the research team specifically for yblmsm aged 15 to 24 who are at-risk for or living with hiv. this model moves beyond the individual to consider the broader context in which, substance use (su), and hiv risk are (re)produced. enhanced models that integrate su treatment into hiv and prep primary care services (using a collaborative care approach that incorporates feedback from a psychiatrist and support from a peer coach) are needed to address the nuance of substance use in this population. we, therefore, are proposing to conduct a randomized trial to evaluate an integrated collaborative care model (cc prtner).

Eligibility criteria:
inclusion criteria: aim 1: * 15-24 years old; * cisgender male; * self-identified black/african american race or latino/hispanic ethnicity; * report prior oral/anal sex with another male; * at-risk for hiv (condomless anal sex or positive sexually transmitted infection (sti) in last 6 months); * moderate-to-high risk su behaviors based upon a car, relax, alone, forget, friends, trouble (crafft) score ≥2, * living in philadelphia, pa or baltimore, md, and surrounding areas; * able to read and write in english aim 2: * 15-24 years old; * cisgender male; * self-identified black/african american race or latino/hispanic ethnicity; * report prior oral/anal sex with another male; * living with a diagnosis of hiv; * crafft score ≥2, * living in philadelphia, pa or baltimore, md, and surrounding areas; * able to read and write in english aim 3 • all randomized study participants will be included in aim 3. exclusion criteria: aim 2: * participants will be excluded if they are: * assigned female sex at birth * identify as transgender * outside the age criteria (\ 24 years old) * cognitively unable to complete study requirements * living outside of the two geographic areas * do not screen positive for su * no prior substance use history * no prior oral or anal sex; * unable to read or write in english, * plan to move in the next 12 months.

Keywords: gay, bisexual young men who have sex with men young black men who have sex with men young latino men who have sex with men hiv aids substance use substances use disorder men who have sex with men young gay men gay men drug use alcohol use preexposure prophylaxis prep peer coaches community health worker lgbt bisexual
montelukast in exercise-induced bronchospasm - 2003 (0476-270)

Conditions: Asthma, Exercise-Induced

Summary: the purpose of this study is to determine the effect of an approved medication being studied in support of a new approach in the prevention of exercise-induced asthma (a worsening of asthma caused by exercise, also known as exercise-induced bronchospasm), in participants who have a history of worsening asthma after exercise.


Eligibility criteria:
inclusion criteria: * participants with mild-to-moderate asthma exclusion criteria: * medical history of a lung disorder (other than asthma) or a recent upper respiratory tract infection
pharmacokinetic study of livalo® fixed combination drug in healthy subjects

Conditions: Hyperlipidemia; Hypertension

Summary: the purpose of this study is to compare pharmacokinetics between pitavastatin and valsartan co-administration and livalo fixed combination drug in healthy male subjects.


Eligibility criteria:
inclusion criteria: * healthy male volunteers * age 20-55 years at the time of screening * bmi 19-26 kg/m2 at the time of screening exclusion criteria: * received other investigational drug within 90 days prior to the first dose of study drug

Keywords: pitavastatin livalo
study of the effect of moxonidine and diet on sympathetic functions in young adults with obesity

Conditions: Obesity; Overweight

Summary: the prevalence of obesity is increasing rapidly among adults and has more than doubled in the past 10 years. the metabolic syndrome (ms) is often associated with obesity. it is characterized by abdominal obesity, high blood pressure, unfavorable blood cholesterol profile, elevated blood sugar and impaired insulin action. persons with the ms have an increased risk of developing type 2 diabetes as well as heart and kidney disease. the prevalence of obesity and ms is also very high in children and young adults. while there are increasing numbers of studies assessing risk factors for cardiovascular and kidney disease in middle aged to older obese subjects, few studies have addressed the issue of the presence of obesity in young adults and its association with ms on early damage to the organs such as the kidneys, the heart and the blood vessels. the investigators' laboratory has a particular interest on the sympathetic nervous system, which is an important regulatory mechanism of both metabolic and cardiovascular function, as altered sympathetic activity may play a role in the complications of obesity. moxonidine is a medication that is approved in australia by the therapeutic goods administration to treat high blood pressure. it works by decreasing the activity of the sympathetic nervous system. with the elevation of the sympathetic activity in obesity, the investigators believe moxonidine may have a favourable role in rescuing early organ damage associated with obesity. this study will assess whether treating obese subjects with moxonidine have positive effects on blood vessels, cardiac and kidney function and anxiety disorder. the investigators will also examine the influence of the sympathetic nervous system activity in these possible altered cardiac, kidney and vessel functions.


Eligibility criteria:
inclusion criteria: * males age between 18 to 30 years old * abdominal obesity according to international diabetes federation (idf) definition exclusion criteria: * any medications * history of cardiovascular disease * history of diabetes * history of psychiatric illness

Keywords: overweight or obese young adults (18 to 30 years old) with no previous history of cardiovascular disease/psychiatric illness, and not on medications
the imaging genetic study of type 2 diabetes and depression

Conditions: T2DM

Summary: to investigate the structural/functional abnormalities and the possible genetic endophenotypes of in the type 2 diabetes patient with depression.

diabetes and depression are harmful to human health,but they often co-exist.at present, the pathophysiological mechanisms underlying the comorbidity of diabetes and depression are discussed, including hypothalamic-pituitary-adrenal axis dysfunction, inflammation, epigenetics, disturbed circadian rhythms, environmental and behavioral factors,neuroimaging,etc.the purpose of the investigator's study is to investigate the structural/functional abnormalities and the possible genetic endophenotypes of in the type 2 diabetes patient with depression.

Eligibility criteria:
inclusion criteria: conform to type 2 diabetes, depression, diagnostic criteria of unrelated normal controls the han nationality patients; aged 30 to 70 years of age, gender not limited; the patient or legal guardian have signed informed consent of patients. exclusion criteria: magnetic resonance imaging has the contraindication, such as metal implants, claustrophobic, etc. with severe body diseases, including inflammatory diseases and autoimmune diseases; current or past history of nervous system disease or brain injury. merge other severe mental illness or existing psychotic symptoms; always have a mania, hypomania attack; has a history of substance abuse; pregnant women and nursing mothers; estimated compliance is poorer, not partners; is being treated for a mental drug therapy, and ect, tms; patients with a body mass index \> 35; there are currently no taking corticosteroids, immune regulator, etc. now or ever did not suffer from patients with other diagnosis to the dsm-iv axis i; merge the endocrine system disease, thyroid, adrenal gland and pituitary gland diseases, etc.
ambulatory heart failure service model study

Conditions: Heart Failure

Summary: the aim of the study is to assess the efficacy of this new ambulatory service model in reducing heart failure hospitalization (hhf), improving clinical as well as functional outcomes of post-discharge patients with heart failure of reduced ejection fraction (hfref) and heart failure with preserved ejection fraction (hfpef).


Eligibility criteria:
inclusion criteria: * dyspnoea (exertional or at rest) and 2 of the following signs: * congestion on chest x-ray * rales on chest auscultation * clinically relevant oedema (e.g. ≥1+ on a 0 to 3+ scale) * elevated jugular venous pressure * nt-probnp ≥300 pg/ml (patients with af: nt-probnp ≥900 pg/ml) * heart failure hospitalization that requires the treatment of a minimum single dose of 40 mg of i.v. furosemide (or equivalent i.v loop diuretics) * ambulatory patients exclusion criteria: * cardiogenic shock required inotropics * cardiac mechanical support implantation like lvad * life expectancy less than 1 year due to underlying significant comorbidities like metastatic cancer or end-stage copd * haemodynamically severe uncorrected primary cardiac valvular disease planned for surgery or intervention during the course of the study. * end stage renal failure or egfr \<15 ml/min/1.73m2 as measured during index hospitalization or requiring dialysis
a study of an investigational zoster vaccine, in subjects with a history of herpes zoster (v211-014)

Conditions: Herpes Zoster

Summary: the purpose of this study is to determine whether the investigational zoster vaccine, is generally well tolerated when administered to participants with a history of herpes zoster.


Eligibility criteria:
inclusion criteria: * adults ≥ 50 years of age with a history of herpes zoster ≥ 5 years prior to enrollment exclusion criteria: * history of allergy to any vaccine component * prior receipt of a varicella or zoster vaccine * ability to defend against infection is suppressed by a medical condition or medication
the "suicide guard rail": a structural intervention for hospitals avoid suicides by jumping from heights buildings

Conditions: Suicide Jumps; Psychiatry

Summary: background: suicides by jumping from the high buildings of acute hospitals are dramatic events which are highly traumatizing to families, staff and fellow pts. in the 10 years from1995 to 2010 the investigators have counted 10 suicide cases despite extensive measures taken to predict and avoid them. the investigators hypothesized that constructive measures at the windows that would render access more difficult could discourage spontaneous suicidal behaviour and would reduce the suicide rates. intervention: starting in 6/2004, a 20 mm diameter metal guard-rail (which resists 250kg) was installed at each window of a 360 bed acute hospital at a height of 113cm, 18cm above the window parapet with the aim to visually, psychologically and physically discourage potential suicidal impulses.


Eligibility criteria:
inclusion criteria: * person at risk for suicide exclusion criteria: * no

Keywords: suicide heights suicide hot spots bridges