Kornimate/medical-research-clean huggingface dataset:
metabolic reprogramming of monocytes in inflammatory flares of inflammatory bowel diseases

Conditions: Inflammatory Bowel Disease (IBD)

Summary: inflammatory bowel diseases, crohn's disease and haemorrhagic rectocolitis, are pathologies that progress in flare-ups, impacting on patients' quality of life and functional or even vital prognosis. these inflammatory diseases require the use of immunosuppressive and immunomodulatory treatments, the side-effects of which can be significant, and the limited number of which sometimes puts patients and practitioners in a therapeutic impasse from which surgery is the only way out. it is therefore important to be able to develop new therapeutic approaches, ideally better tolerated, that can control inflammation during relapses. monocytes are one of the main players in the inflammatory reaction. in the laboratory, we have developed a strategy for the metabolic reprogramming of these cells based on the use of oxygen microbubbles to modulate the inflammatory response of monocytes.


Eligibility criteria:
inclusion criteria: * men and women over 18 * managed at the chuga for a severe ibd flare-up requiring hospitalisation or endoscopy for flare-up * patient not objecting to the repro-mici study exclusion criteria: * patients protected by law (pregnant or breast-feeding women, minors, patients under guardianship or trusteeship, persons deprived of their liberty or hospitalised under duress). * patients with positive hiv, hbv or hcv serology. * patients with a positive elispot with no history of treatment for latent tuberculosis.

Keywords: monocytes metabolic reprogramming
a randomized, equivalence trial of percutaneous lumbar adhesiolysis and caudal epidural steroid injections

Conditions: Low Back Pain

Summary: the purpose of this study is to: * evaluate the effectiveness of percutaneous epidural adhesiolysis in managing chronic low back and/or lower extremity pain in patients without post lumbar surgery syndrome or spinal stenosis and compare with fluoroscopically directed caudal epidural steroid injections. * evaluate and compare the adverse event profile in all groups.

recruitment is indicated in patients with chronic low back pain and/or lower extremity pain without post lumbar laminectomy syndrome or spinal stenosis, non-responsive to conservative therapy with physical therapy, chiropractic, medical therapy, and fluoroscopically directed epidural injections. this is a single-center study performed in an interventional pain management referral center in the united states. the study involves 120 patients assigned to one of 2 groups with 60 patients in each group. data management analysis includes sample size justification of 40 patients in each group with a power of 80% and a 0.05% 2-sided significance level. statistical methodology includes chi-squared statistics, fisher's exact test, t-test, and paired t-test with significance evaluated at p value \< 0.05.

Eligibility criteria:
inclusion criteria: * patients with history of lumbar surgery of at least 6 months duration in the past * patients over the 18 years of age * patients with a history of chronic function-limiting low back pain with or without lower extremity pain of at least 6 months duration * patients who are competent to understand the study protocol and provide voluntary, written informed consent and participate in outcome measurements exclusion criteria: * post surgery, central spinal stenosis, and facet joints as sole pain generators * unstable or heavy opioid use * uncontrolled psychiatric disorders * uncontrolled medical illness * any conditions that could interfere with the interpretation of the outcome assessments * pregnant or lactating women * patients with a history or potential for adverse reaction(s) to local anesthetics or steroid.

Keywords: low back pain post lumbar laminectomy syndrome lumbar spinal stenosis local anesthetic steroid lumbar transforaminal epidural injection percutaneous epidural adhesiolysis caudal epidural injection
validity and reliability of the turkish version of the 4-item short form of the pain anxiety symptom scale

Conditions: Scale Reliability Validity

Summary: the primary aim of the study was to determine the reliability and validity of the turkish version of the 4-item short form of the pain anxiety symptom scale. the secondary aim of the study was to determine the level of pain-related anxiety in individuals with chronic pain.


Eligibility criteria:
inclusion criteria: 1. between the ages of 18-65 2. having pain 4 or more days a week 3. having weekly pain intensity of 3 or more according to the numeric pain rating scale 4. having chronic pain lasting at least 3 months 5. being able to read and write and having no cognitive problems 6. individuals who volunteer to participate in the study will be included. exclusion criteria: 1. having pain limited to headache only

Keywords: pain anxiety reliability validity
safety and efficacy study of bimatoprost in japanese patients with eyelash hypotrichosis

Conditions: Eyelash Hypotrichosis

Summary: this study will evaluate the safety and efficacy of bimatoprost solution 0.03% compared with vehicle in japanese adults with hypotrichosis of the eyelashes.


Eligibility criteria:
inclusion criteria: * have inadequate eyelashes exclusion criteria: * any disease/infection/abnormality of the eye or area around the eye * any ocular surgery within 3 months or anticipated need for ocular surgery during the study * any permanent eyeliner or implants of any kind or anticipated use of false eyelashes * any semi-permanent eyelash tint, dye, curl or eyelash extension application within 3 months * use of any over-the-counter eyelash growth product within 6 months or any use of prescription eyelash growth products * use of treatments which may affect hair growth (eg, minoxidil, chemotherapy) within 6 months
risk factors of spontaneous fungal peritonitis in cirrhotic patients

Conditions: Spontanous Fungal Peritonitis

Summary: spontaneous bacterial peritonitis (sbp) is an infection of the peritoneal cavity with no surgically treatable intra-abdominal source of infection. spontaneous peritonitis is a potentially fatal complication in patients with advanced liver cirrhosis. it is estimated that 10-20 % of patients with cirrhotic ascites may develop spontaneous peritonitis, which is usually caused by a bacterial infection. in contrast, spontaneous fungal peritonitis (sfp) is less well-recognized. sfp may be associated with higher mortality rates than sbp but therapeutic approaches are largely undefined. to this end, the epidemiology and outcomes of patients with sfp have only been documented sporadically aimed to evaluate the risk factors for the development of spontaneous fungal peritonitis (sfp), and the prognosis of sfp compared with sbp

cross-sectional study studied population \& locality: patients with signs and symptoms suggestive of spontaneous peritonitis who will be admitted to tropical medicine and gastroenterology or internal medicine departments in sohag university hospitals during the period from september 2021 to december 2022 will be included in the study. according to the results of ascitic fluid analysis, we will divide the patients into 2 groups: group (1): patients with spontaneous bacterial peritonitis (sbp). group (2): patients with spontaneous fungal peritonitis (sfp). exclusion criteria: patients seropositive for human immunodeficiency virus (hiv) and patients undergoing continuous ambulatory peritoneal dialysis were excluded from this study. methods: all included patients will be subjected to: 1. detailed history, complete general and systemic examination. 2. ascitic fluid analysis 3. bacterial and fungal culture from ascitic fluid: 4. laboratory investigations: fasting blood sugar liver function tests. cbc. ethical considerations:

Eligibility criteria:
inclusion criteria: patients with signs and symptoms suggestive of spontaneous peritonitis who will be admitted to tropical medicine and gastroenterology or internal medicine departments in sohag university hospitals during the period from september 2021 to december 2022 exclusion criteria: patients seropositive for human immunodeficiency virus (hiv) and patients undergoing continuous ambulatory peritoneal dialysis were excluded from this study.

Keywords: spontanous fungal peritonitis, liver cirrhosis, risk factors
an exploratory clinical study evaluating epi-003 injection for the treatment of chronic hepatitis b

Conditions: Chronic Hepatitis B

Summary: this study is an open-label, 2-part (single ascending dose \[part 1\] and dose expansion) study that will evaluate the safety of epi-003 administered to patients with chronic infection with hbv (chb). epi-003 is a liver-targeted antiviral therapeutic for intravenous (iv) injection that is capable of precise epigenetic modifications of the hbv genome without causing mutations in the gene sequence itself.


Eligibility criteria:
inclusion criteria: 1. be between 18 and 65 years of age, inclusive, at the time of signing the informed consent form; 2. confirmed diagnosis of chb; 3. received a stable dose of na therapy for ≥ 6 months prior to screening and plan to continue receiving the same dose for the duration of the study exclusion criteria: 1. confirmed diagnosis of liver cancer or cirrhosis; 2. combination of other major diseases; 3 pregnant or lactating females.
real-time artificial intelligence-based speech enhancement methods for hearing aid improvement

Conditions: Deafness Neurosensory

Summary: individuals with auditory neuropathy spectrum disorders (ansd) represent 1-10% of adults with hearing loss. these individuals have little or no benefit from current hearing aids because ansd is a continuum of hearing impairments due to synaptic or neural dysfunction in the peripheral and central parts of the auditory pathways, which impairs temporal information processing without necessarily affecting auditory sensitivity. there is a need to find ad-hoc denoising methods, based on the expert knowledge of audiologists, to improve the noise comprehension performance of these patients. implemented denoising methods, based on artificial intelligence, will also greatly benefit more standard hearing loss cases.

longitudinal study consisting of multiple visits with multiple examinations over a total duration of approximately 3 years per ansd participant and 1 year per normal hearing participant. * normal hearing participant : year 1 : inclusion visit, phenotyping visit (audiological tests), follow-up visit 1 (noise comprehension tests) * ansd participant : year 1 : inclusion visit, phenotyping visit (audiological tests), follow-up visit 1 (noise comprehension tests) year 2 : follow-up visit 2 (noise comprehension tests) year 3 : follow-up visit 3 (noise comprehension tests)

Eligibility criteria:
inclusion criteria: for all participants: * age greater than or equal to 18 years, * french mother tongue, * have an average tonal hearing loss (calculated according to the biap method) \< 30 db hl, on headphones, for each ear, * be professionally active, not be pre-retired and not be unemployed * be affiliated with a social security plan, for participants with tsna: - have degraded comprehension in noise (threshold of intelligibility in noise \> 3 db compared to the norm). for controls: - have normal comprehension in noise (intelligibility in noise threshold ≤ 3 db from the norm). exclusion criteria: for all participants: * have a conductive or mixed hearing loss, which is when the hearing loss affects both the outer and/or middle ear and the inner ear. * have an asymmetric hearing loss, i.e. a difference in average hearing loss between the left and right ear greater than 30 db, * have sequelae of ear infections and/or a history of ent disease that permanently affects hearing (vestibular schwannoma, meniere's disease, sudden or fluctuating deafness, congenital hypoacusis) * being under guardianship, * being deprived of liberty by judicial or administrative decision, or being subject to legal protection.

Keywords: spectrum of auditory neuropathy speech enhancement intelligibility denoising methods hearing loss
a prospective study comparing two reconstructive operation techniques after myotomy of achalasia

Conditions: Achalasia

Summary: achalasia is a rare motor disorder of the gastroesophageal junction which is associated with an increased pressure of the esophageal sphincter. this leads to impairment to swallow and heartburn. esophageal myotomy, which is a surgical longitudinal incision of the esophageal muscle layer extending over to the gastroesophageal junction is the treatment of choice for achalasia. in order to prevent reflux of stomach content into the esophagus this has to be combined with an antireflux procedure where the upper part of the stomach (fundus) is wrapped around the esophagus (fundoplication). this procedure can be performed with the wrapped fundus either in front of the esophagus (dor procedure) or behind (toupet). the latter introduces an angulation of the esophagus, which possibly may lead to an impairment of swallowing ability and passage of food to the stomach. on the other hand, the toupet procedure may give a better control of reflux. the primary endpoint of the study is symptoms of impaired swallowing 1 year after treatment. secondary outcomes include reflux (ph measurements in the esophagus), radiological imaging of swallowing and quality of life.

by the end of 2012 40 patients have been enrolled and passed the one year follow up.

Eligibility criteria:
inclusion criteria: * \>18 years of age * typical achalasia according to manometry * eckhardt score \>3 * informed consent exclusion criteria: * severe comorbidity precluding surgery * pseudo achalasia * inability to participate in follow-up

Keywords: randomized toupet dor achalasia
characterization of the cord blood stem cell in situation of neonatal asphyxia

Conditions: Respiratory Distress Syndrome

Summary: neonatal anoxic-ischaemic enkephalopathy is a dramatic perinatal complication due to brain asphyxia. neurological and neurosensory sequelae are frequent in survivors, due to neuronal damage and loss. for the moment, only total or partial body hypothermia can partially prevent cell loss. however, no treatment exists to restore neuronal functions. cord blood stem cells are a promising treatment for the near future. however, before conducting a clinical trial to evaluate the safety and feasibility of autologous cell therapy in neonatal asphyxia, in vitro characterization of the cord blood stem cell in situation of neonatal asphyxia, compared to normal situation, is needed. the primary objective of this study is to characterize cord blood stem cells of neonates with neonatal asphyxia and to compare them with those from healthy newborn. the quantitative and qualitative, functional characterization will insist on cell populations which could potentially participate to neuronal regeneration. secondary objectives are to assess such characteristics in conditions of cryo-preservation, compared to fresh cell preparation

methods : descriptive, bi-centre study on 10 cord blood samples from newborn infants with neonatal asphyxia (5) according to pre-defined criteria, compared healthy neonates (5). the total duration of the study will be 2 years. parents will be informed and a signed parental consent will be asked in the hours following birth before the in vitro study. biological analysis will include elementary analyses for cell quality control, endothelial progenitor exploration, and investigation of mesenchymal stem cells function and of their neuronal differentiation potential (on fresh and frozen samples). statistical analysis: comparison between the 2 groups (neonatal asphyxia versus control) would use non parametric test (mann-whitney) this study will allow to evaluate the therapeutic potential of cord blood stem cells autologous transplantation in neonatal asphyxia. it will contribute to the determination of the feasibility of a clinical trail of autologous, cord blood stem cells therapy in such disease.

Eligibility criteria:
inclusion criteria: * delivery at 37 week or more of pregnancy * normal pregnancy and delivery exclusion criteria: * parental refusal

Keywords: cord blood stem neonatal asphyxia
the effect of a real-time audiovisual feedback system on cpr quality

Conditions: Cardiopulmonary Resuscitation

Summary: the investigators will evaluate the effect of a real-time audiovisual feedback system on cpr quality during in-hospital cardiac arrest.


Eligibility criteria:
inclusion criteria: * patients over 17 years old who require cardiopulmonary resuscitation in a medical or surgical intensive care units exclusion criteria: * patients less than 18 years * patients with do not resuscitate order * patients who require cardiopulmonary resuscitation outside a medical or surgical intensive care unit
mri thermal imaging of infants undergoing cooling for hypoxic ischemic encephalopathy(hie)

Conditions: Hypoxic Ischemic Encephalopathy

Summary: hundreds of babies in the world are being treated with brain cooling to prevent brain injury after they lose oxygen at birth. this study will use the newly developed information from the magnet resonance image to determine the actual temperature of the brain. this will enable us to determine if the brain is being uniformly cooled and if techniques that provide cooling need to be changed to improve the injury prevention from cooling.

we propose to develop a non-invasive measurement of brain tissue temperature and to apply this measurement of infants under-going cooling for hie 1. we propose to do this by refining the use of the mri evaluation of the naa-h20 frequency shift. this molecular relationship is quite accurate (based on preliminary studies of an naa-h20 phantom subject to controlled temperature variations) for measuring relative temperature changes. 2. the next step will be to perform further phantom imaging with continuous temperature measurements and to expand the phantom model. this work needs funding support to be completed. 3. at the same time we will be applying the mri thermal imaging protocol to infants whom have experienced hie and who are being treated with hypothermia to ameliorate the hie. we have irb approval to approach families and to obtain the required data during clinically indicated mri scans, this data accumulation will add an additional 3-5 minutes to the mri. we will then perform a second mri after the infant is rewarmed. we will compare the pairs of readings at two different core temperatures from at least five regions of the brain. 4. we will evaluate results of regional temperature measurements to determine if cooling of the human infant brain is uniform. 5. we will compare the two modalities of cooling to determine if selective head cooling and total body cooling provide similar distribution of cooling. 6. the final goal will be to compare mri identified injury patterns to the temperature distribution in order to determine if distribution of cooling is related to outcome.

Eligibility criteria:
inclusion criteria: * infants in the nicu who are treated with hypothermia for hypoxic ischemic encephalopathy and who are scheduled to have an mri for evaluation of the extent of their injury. * parent and attending physician consent to perform evaluation of mri thermography. exclusion criteria: * infants too unstable to have mri scan, defined by being on any cardiac pressor medications or more than 40% oxygen on the ventilator. * infants too active to obtain mri without sedation.

Keywords: hypoxic ischemic encephalopathy magnet resonance imaging selective head cooling therapeutic hypothermia
borg score outcomes in respiratory compromised acute exacerbating chronic obstructive pulmonary disease (copd) patients receiving treatment via vibrating mesh nebuliser versus jet nebuliser in the emergency department

Conditions: COPD Exacerbation; COPD

Summary: the purpose of this study is to compare clinical outcomes in patients with acute copd treated with a vibrating mesh nebuliser (vmn) versus a current standard jet nebuliser (jn), in the emergency department (ed). participants will be those who meet the inclusion criteria and have a primary diagnosis of copd, and consent to take part in the study. operators will be clinical staff including doctors and nurses who will be trained in the use of the nebulisers. delivery of current treatment standards utilising a vmn compared to a jn will improve symptom scores in patients attending ed with copd exacerbations.

this study is a prospective, single-centre, open, randomised study to improve management of acute copd exacerbation within the emergency department. adults with severe copd are randomised into 2 groups: vibrating mesh nebuliser or standard jet nebuliser treatment. salbutamol (5mg) and ipratropium (0.5mg) will be administered via aerogen ultra via valved mask or a standard jet nebuliser via open face mask/. two further doses of salbutamol to be delivered.

Eligibility criteria:
inclusion criteria: * • primary presentation with acute exacerbation of copd exclusion criteria: * • unable to give valid consent * patient unable to speak english * patients where alternative diagnosis cannot be excluded * known or suspected pneumonia, pneumothorax, pneumomediastinum, pulmonary oedema, vocal cord dysfunction, aspirated foreign body * any contraindication to delivering bronchodilators * need for immediate intubation , ventilation or non-invasive ventilation * pregnant or lactating * active palliation considered or expected mortality within 48 hours * known background/ comorbid respiratory disease associated with chronic or variable airflow obstruction (significant goitre, central lung tumour or other central airway pathology, bronchiectasis)

Keywords: nebulisation vibrating mesh nebuliser