Kornimate/medical-research-clean huggingface dataset:
castleman disease collaborative network biobank

Conditions: Castleman Disease; Castleman's Disease; Giant Lymph Node Hyperplasia; Angiofollicular Lymph Hyperplasia; Angiofollicular Lymph Node Hyperplasia; Angiofollicular Lymphoid Hyperplasia; GLNH; Hyperplasia; Giant Lymph Node

Summary: the purpose of this study is to create a biobank, which collects, stores, and distributes samples of human tissues, blood, and related health information to qualified scientists, in order to help doctors and researchers better understand why castleman disease occurs and develop ways to better treat and prevent it.

the cdcn proposes to establish a biobank and associated clinical data for castleman disease. tissue and fluid (blood and saliva) samples will be collected both prospectively and retrospectively. blood or saliva samples may also be collected from relatives of castleman patients. because of the scarcity of these samples, it will be necessary to make efforts to access all available cases. many cases will occur at hospitals that do not have an existing relationship with the cdcn and may not have experience with tissue procurement; however, this is the only way to obtain the vast majority of samples. samples may be used immediately, banked for future use, or further processed into dna, cell lines, tissue microarrays, etc. the samples will be stored at precision for medicine, a biorepository company that specializes in collection, processing, storage and distribution of biospecimens. only researchers (us or international) who have applied to the cdcn and have been approved by the biobank advisory board will be eligible to access biospecimens and/or data. the biobank advisory board will be comprised of clinicians and scientists with experience in clinical and investigational practices in castleman disease.

Eligibility criteria:
inclusion criteria * potential study participants may be of any age, gender, or ethnicity who have been diagnosed with castleman disease exclusion criteria * none

Keywords: biobank biorepository castlebank castleman disease cd mcd imcd castleman castleman's disease multicentric castleman's disease multicentric castleman disease angiofollicular lymph hyperplasia
comparison of occupational therapy and home exercises for adults with operatively treated distal radius fractures

Conditions: Distal Radius Fractures

Summary: the purpose of this study is to compare to ways of rehabilitating after surgery for distal radius fractures treated operatively with a volar plate.

operative treatment of distal radius fractures has become commonplace over the last three decades as our understanding of the relationship between the alignment of the distal radius and the function of the wrist and forearm has improved. over the last 15 years there has been a trend towards more invasive, internal plate fixation of fractures of the distal radius. one argument in favor of internal fixation for these fractures is that it would be beneficial to allow early movement of the wrist articulation in an attempt to maximize final outcome. there is a difference in opinion among physicians on the importance of supervision of exercises in the recovery process. some physicians advocate formal occupational therapy while other physicians believe that appropriate instructions for home exercises are just as good. a common belief is that the motivation of the patient plays an important part in recovery. in addition, psychological and personality factors, such as pain anxiety, catastrophizing, and depression are strongly related to upper extremity specific health status and may also influence recovery. the goal of this study is to determine which protocol for exercises leads to better outcome in patients treated for distal radius with a volar plate. as a secondary goal and to generate hypotheses for later studies we would like to evaluate the influence of psychosocial factors on both objective (motion, grip strength) and subjective (dash questionnaire) measures of functional recovery.

Eligibility criteria:
inclusion criteria: * age 18 or greater. * isolated distal radial fracture. * fracture treated with volar plates, stable fixation. * initial treatment within 4 weeks of trauma. exclusion criteria: * complex fractures that require additional or different material than volar plates.

Keywords: distal radius fracture rehabilitation volar plate fixation dash questionnaire
home away from home - medical outcomes

Conditions: Acute Myeloid Leukemia; Neutropenia; Bacteremia

Summary: treatment for pediatric acute myeloid leukemia (aml) involves intensive chemotherapy regimens that result in periods of profound neutropenia leaving patients susceptible to severe infectious complications. infectious complications are the leading cause of treatment related mortality among aml patients, but there are little clinical data to inform whether management of neutropenia post aml chemotherapy should occur in an outpatient or inpatient setting. the primary objective of this study is to compare the clinical effectiveness of outpatient versus inpatient management of neutropenia in children with aml.

this is a bidirectional observational cohort study. participants will be patients less that 19 years of age at diagnosis receiving or having received chemotherapy for aml from seventeen participating pediatric hospitals across the united states. there is no study intervention; this is a medical record abstraction study only. investigators will abstract subjects medical record data over the study period in order to study clinical outcomes including the occurrence of bacteremia and time to the start of the next course in the chemotherapy regimen, in relation to neutropenia management strategy.

Eligibility criteria:
inclusion criteria: 1. males or females of age less than 19 at diagnosis. 2. receipt or planned receipt of aml chemotherapy between january 1, 2012 and december 31, 2019. exclusion criteria: 1. patients being treated for relapsed aml 2. patients with acute promyelocytic leukemia (apml) 3. patients undergoing stem cell transplant (sct) 4. patients receiving reduced intensity frontline chemotherapy

Keywords: pediatric neutropenia management acute myeloid leukemia chart abstraction chemotherapy
the impact of congenital heart disease on the psychological well being and quality of life in the hong kong chinese adolescents

Conditions: Congenital Heart Disease

Summary: this study aims to examine the psychological well-being and qol of hong kong chinese adolescents with chd by * comparing the self-esteem level, depressive symptoms, and quality of life of adolescents suffering from chd with healthy norms and cancer survivors. * identifying possible factors affecting the quality of life of adolescents suffering from chd.

congenital heart disease (chd) is the most common type of congenital malformation in the world with birth prevalence as 8 per 1000 live births. survival rate has been drastically improved as a result of improvement in surgical treatments and intensive care but adolescents with chd still suffer from limitations on their psychological functioning and restrained quality of life. number of evidences have indicated that adolescents with chd experience more depressive symptoms and lower self-esteem level than their healthy counterparts. in addition, adolescents with chd are more prone to develop emotional and behavioral problems than their healthy norms. given the above issues, it is imperative for nurses to develop psychological interventions to promote psychological well-being among adolescents with chd, with the goal of improving their quality of life. there have been increasing concerns worldwide on the quality of life of such population especially on how does the disease pose threats on their daily living. however, at present, there is no study examining how does chd affect the psychological well-being and quality of life in hong kong chinese adolescents. it is explicit that hong kong has a distinctively different cultural context from that of the west. hence, the effects of chd and its treatments are likely to differ markedly in the two regions .to conclude, results of previous studies from the west may not fit into hong kong chinese cultural context.

Eligibility criteria:
inclusion criteria: * pediatric patients with congenital heart disease * aged at 12-17 years old * fluent in cantonese and able to read chinese exclusion criteria: * pediatrics with major developmental delay or having significant co-morbid medical condition * visiting because of altering in clinical condition * having acquired heart disease or non-structural heart disease

Keywords: adolescents quality of life psychological well-being
treatment of primary peritoneal carcinosis of digestive origin using cytoreductive surgery and hyperthermic intraoperative peritoneal chemotherapy with mitomycin c and irinotecan

Conditions: Peritoneal Carcinosis (PC)

Summary: this is an open, non-randomized, phase i-ii, pilot study, which evaluates the combination of optimum cytoreductive surgery and hyperthermic intraoperative peritoneal chemotherapy (hipec) with mitomycin c (mmc) and irinotecan. the latter drug will be administered in escalating doses to patients with gastric, colorectal, appendicular, or primary peritoneal carcinosis (pc).


Eligibility criteria:
inclusion criteria: * patients with a peritoneal carcinosis (pc) either of digestive origin or primary: a colorectal or gastric carcinosis, a peritoneal pseudomyxoma or mesothelioma, or a primary carcinosis of the peritoneum regardless the number of prior treatment lines. * a pc and primary tumor considered to be resectable according to preoperative clinical and paraclinical data: absence of mesenteric retraction and absence of bladder invasion. * patients in good general health (asa ≤ 2). * absence of cardiorespiratory failure (pao2 \> 60 mmhg in a stable condition, dyspnea ≤ nyha stage 1, left ventricular ejection fraction \> 60%.). * prothrombin level \>70 %, total bilirubin \< 2 x the normal level, asat and alat \< 2.5 x normal levels, and alkaline phosphatases \< 5 x normal levels. * creatinine clearance \> 60 ml/min, polynuclear neutrophils \> 1500/mm3, and a white blood cell count \> 4000 /mm3. * patients who give written, informed consent. * patients affiliated with the french universal healthcare system. exclusion criteria: * patients with a pc with ovarian, mammary, biliary, pancreatic, or bronchial origin. * evolutive patients after systemic chemotherapy. * patients with a pc considered to be irresectable according to preoperative clinical and paraclinical data: mesenteric retraction or bladder invasion. * patients in poor general health (asa \> 2). * cardiorespiratory failure (dyspnea \> nyha stage 1, pao2 \< 60 mmhg in a stable condition) * prothrombin level \< 70 %. * any brain abnormality showing on the head scan. * signs of heart failure and especially left ventricular ejection fraction \< 60% on the cardiac ultrasound. * thrombocytopenia \< 100 000 / mm3 * visceral metastases other than a single resectable liver metastasis. * pregnancy or breast feeding. * chronic inflammatory intestinal disease and/or an intestinal obstruction. * history of severe hypersensitivity to irinotecan hydrochloride trihydrate or one of the excipients of campto. * bilirubinemia \> 3 times the normal upper limit * yellow fever vaccine. * prophylactic treatment with phenytoin. * severe medullary insufficiency.

Keywords: hyperthermic intraoperative peritoneal chemotherapy (hipec) irinotecan pharmacokinetics peritoneal carcinomatosis (pc)
saphenous nerve radiofrequency for knee osteoarthritis trial

Conditions: Osteoarthritis, Knee

Summary: this project is one of four components of a thematic project that aims to evaluate the use of ultrasound in regional and infiltration blocks, called "use of ultrasound in regional blocks and infiltration for the treatment of acute and chronic pain". it aims to evaluate quantitatively and qualitatively the knee pain control in patients with osteoarthritis after neurotomy by saphenous nerve radiofrequency guided by ultrasound , compared to neurotomy by radiofrequency of genicular nerves guided by fluoroscopy . differences between total consumption of analgesics, side effects of medications , impact on quality of life and functional capacity in patients undergoing saphenous nerve neurotomy by radiofrequency guided by ultrasound compared to neurotomy by radiofrequency of genicular nerves guided by fluoroscopy, will also be evaluated.

background: osteoarthritis of the knees is currently a major public health problem, with patients suffering from pain and functional limitation. depending on the severity of the impairment, the definitive treatment is surgical, but the old ages often associated and morbidities present in these patients some times limit such conduct. more effective treatments for pain control are necessary. objectives: to evaluate quantitative and qualitative pain control in patients with osteoarthritis in knees after neurotomy of saphenous nerve by radiofrequency guided by ultrasound, compared to neurotomy by radiofrequency of genicular nerves guided by fluoroscopy. methods: this was a prospective, randomized clinical study and blind to the evaluators. will include 20 patients with knee osteoarthritis grade iii or iv, refractory to medical treatment. a group will be submitted to neurotomy by radiofrequency of genicular nerves guided by fluoroscopy and the other group will receive neurotomy by radiofrequency of saphenous nerve, guided by ultrasound. they will be assessed in pain intensity at rest and movement, functionality, satisfaction and adverse effects related to treatment. patients will be evaluated 15 days, 1 month, 3, 6 and 12 months after the procedure.

Eligibility criteria:
inclusion criteria: * will be included patients older than 18 years, who have moderate to strong chronic pain in knee on most of the days days for at least 3 months, with osteoarthritis of the knee documented by graded radiologically at 3 to 4 in kellgren-lawrence rating, refractory to medical treatment (physical therapy, oral analgesics, intra-articular injections of hyaluronic acid or corticosteroids). exclusion criteria: * the exclusion criteria are: acute knee pain, prior surgery on the knee, another connective tissue disease affecting the knee, psychiatric or neurological disorders, intra-articular injection of hyaluronic acid or corticosteroid for less than 3 months, pain related to nerve sciatic, use of anticoagulants and pacemaker.

Keywords: osteoarthritis, knee pulsed radiofrequency treatment ultrasonography, interventional
therapeutic use of angiopoietin-primed autologous peripheral blood stem cell in myocardial infarction

Conditions: Acute Myocardial Infarction

Summary: this study will evaluate the efficacy and safety of "therapeutic use of autologous-primed autologous peripheral blood stem cell treatment for myocardial regeneration in acute myocardial infarction".

patients diagnosed with acute myocardial infarction will receive percutaneous coronary intervention to the culprit coronary artery according to standard procedures. for peripheral blood stem cell mobilization, granulocyte colony-stimulating factor (g-csf) and erythropoietin (epo) will be injected for a total of 4 days, followed by collection of mobilized peripheral blood stem cell (mobpbsc) via apheresis. in ex-vivo setting, mobpbsc will be primed with angiopoietin 1 (ang1) for 1 hour. a total of 2 x109 ang1 primed mobpbsc will be injected to the culprit artery.

Eligibility criteria:
inclusion criteria: * 1. male and female aged ≥19 years and ≤ 80 years * 2. a clinical diagnosis of acute myocardial infarction within 4 weeks from randomization * 3. successful percutaneous coronary intervention to the target lesion (timi flow grade 3 and residual stenosis \<30% at the target lesion) with a drug-eluting stent and/or drug-eluting balloon * 4. agreement to give written informed consent. exclusion criteria: 1. patients with uncontrolled heart failure (killip class ≥ grade 2, or left ventricular ejection fraction \<20%) 2. patients with uncontrolled chest pain due to ischemia 3. patients with uncontrolled arrythmia 4. active malignancy, or incompletely treated malignancy 5. active infectious disease 6. uncontrolled hematologic disease, including coagulopathy or bleeding diathesis 7. presence of non-cardiac comorbidity with life expectancy ≤1 year from randomization 8. females with childbearing potential or breast-feeding 9. refusal to give written informed consent 10. other conditions that may result in protocol non-compliance by the committees

Keywords: peripheral blood stem cell treatment acute myocardial infarction
study evaluating impact of the use of a computer-based tool on the clinical management of ra patients

Conditions: Rheumatoid Arthritis

Summary: the primary purpose of this study is to evaluate a computer-based tool on the clinical management of patients with rheumatoid arthritis in spain.


Eligibility criteria:
inclusion criteria: main inclusion criteria: * patients, male or female, over 18 years old. * patients diagnosed with ra according to investigator criteria * patients with a disease evolution \>= 1 year * patients with \> = 5 affected joints exclusion criteria: exclusion criteria: * patients with other muscle skeletal, rheumatic and/or degenerative diseases different from ra. * patients who are taking part or have taken part in a clinical trial or in a study with drugs within the last 12 months. any condition that, in the investigator's judgment would interfere with the subject's ability to comply with protocol requirements or give informed consent.
study to evaluate the safety and efficacy of levetiracetam in patients suffering from idiopathic generalized epilepsy with primary generalized tonic-clonic seizures

Conditions: Generalized Convulsive Epilepsy

Summary: this study will assess the efficacy, safety, and tolerability of adjunctive treatment with lev (3,000 mg/day or a target dose of 60 mg/kg/day in children) compared to placebo in reducing pgtc seizures in subjects (4 - 65 years) suffering from idiopathic generalized epilepsy uncontrolled despite treatment with one or two concomitant aeds.


Eligibility criteria:
inclusion criteria: * subject with a confirmed diagnosis consistent with idiopathic generalized epilepsy experiencing primary generalized tonic-clonic seizures (iie) that are classifiable according to the ilae classification of epileptic seizures. * presence of at least 3 pgtc seizures during the 8-week combined baseline period. * absence of brain lesion documented on a ct scan or mri. * an eeg performed within 1 year of visit 1 with features consistent with pgtc seizures or generalized idiopathic epilepsy. * male/female subject, \>=4 or \<=65 years of age at visit 1. * subject on a stable dose of one or two aeds during baseline. exclusion criteria: * previous exposure to levetiracetam. * history of partial seizures. * history of convulsive or non-convulsive status epilepticus while taking concomitant aeds within three months prior to visit 1.

Keywords: idiopathic generalized epilepsy, tonic-clonic seizures levetiracetam, keppra
assessment of substitution of focused cliches and ultrasound for tomosynthesis

Conditions: Breast Cancer; 2D Mammography; 3D Mammography

Summary: this study aims to assess if using tomosynthesis for breast cancer surveillance will allow a significant decrease of ultrasound cliches (and radiation exposure)


Eligibility criteria:
inclusion criteria: * woman with breast cancer histologically proven (group 1), on surveillance of a treated breast cancer (group 2) or diagnosis of an detected anomaly * age ≥ 40 years (group 1, group 2); age ≥ 50 years (group 3) * breast size suitable for detector size * possible prior mastectomy * security social covered * signed informed consent exclusion criteria: * breast implant * high genetic risk (mutation) * under justice measures * breast feeding or pregnant woman

Keywords: breast cancer surveillance diagnosis 2d mammography 3d mammography
monitoring telemedicine platform in patients with anxiety symptoms and alcohol use disorder

Conditions: Anxiety Disorders; Alcohol Use Disorder; Depressive Disorder

Summary: the objective of this study is to analyze the physiological patterns of two groups of patients, one control and one with anxiety disorder and alcoholic abuse disorder using sensor data from mobile devices and wearables. this data will be compared to the data presented by three clinical questionnaires: state-trait anxiety inventory (stai), the alcohol use disorders identification test (audit), and the beck's depression inventory (bdi-ii) in order to determine the feasibility of remote collected data.

the objective of this study is to analyze the physiological patterns of two groups of patients, one control and one with anxiety disorder and alcoholic abuse disorder using sensor data from mobile devices and wearables. this data, collected by sensors, will be compared to the data presented by three clinical questionnaires: state-trait anxiety inventory (stai), the alcohol use disorders identification test (audit), and the beck's depression inventory (bdi-ii) in order to determine the feasibility of using remote collected data in routine clinical practice. furthermore, patient satisfaction with the app will be evaluated after the data collection phase. this is a unicentric, case-controlled, longitudinal, evaluational, national study with two groups, one control of healthy individuals without symptoms of anxiety or depression, and another experimental group in which participants fulfill the given selection criteria for the trial. there are a total of 60 participants split evenly between the two groups.

Eligibility criteria:
inclusion criteria: * 18-65 years of age. * alcohol use disorder (dsm 5) as main substance. * anxiety (stai \> percentile 33) and, if depressive symptoms, not clinically relevant as to accomplish dsm5 diagnostic criteria for mood disorders (major depressive disorder, bipolar disorder...). * having a mobile phone compatible with android. * sign informed consent. exclusion criteria: * mood disorder diagnoses (dsm5). * cognitive deficits that prevent the participation. * active intake of other substances (except for nicotine).

Keywords: wearable sensor anxiety monitoring ehealth alcohol use disorder depression