Kornimate/medical-research-clean huggingface dataset:
work place adjusted intelligent physical exercise reducing musculoskeletal pain in shoulder and neck

Conditions: Musculoskeletal Disorders

Summary: musculoskeletal disorders are frequent among office workers especially in the neck/shoulder area. the hypothesis is, that specific strength training of the neck/shoulder muscles will alleviate the pain. the two sub-hypotheses are 1. alleviation of pain is independent of training frequency 2. alleviation of pain is higher following supervised training vs training with initial instruction only

recent studies have shown a positive effect of work site physical exercise intervention, however, there is a lack of evidence regarding: 1) extend of instruction and supervision, and 2) frequency of training session during the wek. questionnaires will be send to around 2000 office workers inviting them to participate in work site training for 1 hr per week for 20 weeks. those accepting the invitation will be randomized into 5 different groups: 1. training 1 hr one time per week supervized 50% of the time 2. training 3 x 20 min per week supervised 50 % of the time 3. training 3 x 20 min per week supervised only initially with careful instructions 4. training 10 x 6 min per week supervised 50 % of the time 5. no training serving as reference control group at termination of the training period there will be a follow-up questionnaire survey

Eligibility criteria:
inclusion criteria: * office workers * employed exclusion criteria: * physically heavy work * trauma * leif threatening disease, e.g. cancer, * pregnancy

Keywords: neck/shoulder
an educational intervention to improve disease management knowledge of hospitalized patients with copd

Conditions: Chronic Obstructive Pulmonary Disease; Patient Education; Inpatients

Summary: the objective of this study is to determine if inpatient copd education would result in improved patient knowledge of copd.

a prospective cohort study utilizing a pre-test/post-test design will be used to test a copd education intervention on a convenience sample of 30 patients with a diagnosis of copd. study participants will complete the chronic obstructive pulmonary disease questionnaire (copd-q) to assess their copd knowledge. next, a respiratory therapist will provide the first scripted copd education session. the patient will complete the copd-q 24 hours and 30 days post-discharge. demographic data, smoking status, pack-years, copd spirometry grade, copd symptom and exacerbation grade, previous hospital admissions, support system for managing copd, attendance at previous formal education for copd, current and home medications, pulmonary function test (pft) results, vaccinations, and level of education data will be collected. data related to patient recruitment will also be collected. means and standard deviation will be reported for interval data. total frequency and percentages will be reported for nominal data, and median and 25th and 75th percentile will be reported for copd severity. repeated measures anova (p\< 0.05) will be used to evaluate if an inpatient copd self-management intervention can increase the patient's knowledge of copd after 24 hours and again at 30 days after the initial education session. this study is expected to show that an inpatient education of copd can increase the patient's copd knowledge prior to discharge and that it will be retained for at least one month post-discharge.

Eligibility criteria:
inclusion criteria: * history of copd * spirometry confirmation of copd either from chart or bedside spirometry i. fev1(forced expiatory volume in 1 second)/fvc (forced vital capacity) \<70% ii. fev1 \< 80% predicted * willingness to participate * english-speaking * working phone exclusion criteria: * cognitively impaired (including sedation) * intubated * non-english-speaking * receiving palliative or hospice service * enrolled in any other educational research s
systematic approach for the diagnosis and treatment of obstructive lung diseases

Conditions: Chronic Obstructive Pulmonary Disease; Asthma; Overlap Syndrome

Summary: the differential diagnosis of asthma and copd is sometimes difficult. recently, an overlap syndrome has been defined based on the concurrence of asthma and copd characteristics. these characteristics are based on expert opinions and have never been investigated nor validated prospectively. the investigators assume that the management strategy, the symptom burden and disease progression will differ between asthma, copd and acos. therefore, the study wants to establish baseline criteria for an appropriate disease definition and evaluate the potential impact on treatment and symptom control.

this study aims to test a diagnostic algorithm for obstructive airways diseases that may be used in daily practice to obtain a correct differential diagnosis and, hence, initiate an adequate therapy according to the current guidelines. the proposed algorithm will be used to categorize patients in 4 different diagnoses with specific treatment choices: asthma, obstructive asthma, overlap asthma with copd, and copd. the study will evaluate which tests and criteria contribute most to the diagnostic work-up and final diagnosis. test battery for diagnosis * spirometry with bronchodilator reversibility testing * bodyplethysmography: spirometry, volumes, resistance, diffusing capacity * exhaled no * blood sample * ct scan of thorax (only when obstructive spirometry) * histamine challenge (only when spirometry is not obstructive) * induced sputum (not for protocol interpretation) definition of endpoints 1. physician based diagnosis: diagnosis based on clinical exam and spirometry 2. algorithm based diagnosis: diagnosis based on clinical exam and test battery 3. final standard diagnosis diagnosis based on clinical exam, test battery and clinical evolution of 1 year.

Eligibility criteria:
inclusion criteria: * subjects with respiratory symptoms suggestive of chronic airway disease exclusion criteria: * subjects with an immediate need for hospitalization or a treatment of systemic glucocorticoid or long-term antibiotics * subjects with pregnancy * subjects with clinically significant cardiovascular disease that warrants intervention * subject with concomitant pulmonary diseases (pulmonary embolism, interstitial lung disease etc..).
post-surgical outcomes measure using the eras protocol for posterior cervical decompression and fusion

Conditions: Degenerative Spinal Arthritis; Cervical Myelopathy; Spinal Stenosis

Summary: this research study is being conducted to help improve the pre-operative, intra-operative, and post-operative course for patients and enhance recovery.


Eligibility criteria:
inclusion criteria: * age 18 to 89 * diagnosis of cervical myelopathy, cervical stenosis, cervical disc disorder, or cervical spondylolisthesis exclusion criteria: * cervical injury as the indication for surgery * emergent surgery
animal-assisted or robot-assisted interventions in health promotion for elderly with dementia

Conditions: Dementia

Summary: the overall research aim of this study is to investigate changes in measures related to the risk of falls among elderly with dementia participating in animal-assisted or robot-assisted interventions. in addition the study will investigate how knowledge transfer occurs among involved health personnel, and how knowledge is refined and transformed as practical competence. the design will be a prospective and cluster randomized multicenter trial, but mixed-methods will be used to target different outcomes. the study population will be elderly (age above 65) at nursing homes diagnosed with dementia, or having a cognitive deficit. the intervention will consist of 30 minutes sessions with animal-assisted activity or robot-assisted activity two times a week for 12 weeks in groups of 4-6 participants. control groups will receive treatment as usual. research questions: 1. is there an effect in use of ordinary and optional medication among elderly persons with dementia at nursing homes participating in animal-assisted or robot-assisted interventions compared to a control group? 2. is there an effect on agitation, restlessness and depression among elderly persons with dementia at nursing homes participating in animal-assisted or robot-assisted interventions compared to a control group? 3. is there an effect on social interaction, activeness and wellbeing among elderly persons with dementia at nursing homes participating in animal-assisted or robot-assisted interventions compared to a control group?


Eligibility criteria:
inclusion criteria: - diagnosis of dementia or having a cognitive deficit measured as a score less than 25 on mini-mental state examination. exclusion criteria: * fear of dogs * dog allergy * need of wheel chair
evaluation of the effectiveness, safety, and cost of a smart home-based hospital system for patients with interstitial lung disease: prospective multicenter randomized controlled trial

Conditions: Interstitial Lung Disease

Summary: this study aims to analyze the effectiveness/safety/cost of the smart homespital system that provides a service that allows patients with interstitial lung disease to easily access and use biosignals generated using biosignal collection medical equipment at home.


Eligibility criteria:
inclusion criteria: patients diagnosed with copd who meet the following pulmonary function test results: 1. pre fev1 \< 80% \*\*or\*\* 2. pre fvc \< 80% \*\*or\*\* 3. dlco \< 60% exclusion criteria: 1. patients who do not agree to participate in the study. 2. patients who fail to use the medical device equipment. 3. patients where tracking during the study period is expected to be impossible. 4. patients who have difficulty communicating verbally. 5. patients who are bedridden or unable to exercise at all due to severe cardiorespiratory dysfunction. 6. patients receiving hospital-centered rehabilitation treatment during the study period.
exploratory study, evaluating the treatment effect of surgery plus gliadel® wafer in patients with metastatic brain cancer

Conditions: Metastatic Brain Cancer

Summary: the purpose of this study is to determine the effect of the surgical intervention and insertion of gliadel wafers on the neurocognitive functioning in patients with metastatic brain cancer.


Eligibility criteria:
inclusion criteria: 1. can provide signed/dated informed consent, and health insurance portability and accountability act of 1996 (hipaa) authorization. 2. are a male or female patient 18 years of age or older. 3. are willing to a use barrier method of contraception if fertile or of childbearing potential until 30 days after surgical resection. if the patient receives subsequent chemotherapy during study participation (as allowed by the protocol), appropriate contraception will be managed by the principal investigator. 4. have a primary diagnosis of solid-based tumor cancer (except small cell lung cancer (scls), lymphoma, germ cell cancer or anaplastic thyroid cancer) or unknown primary cancer and have 1-3 brain metastasis(es) for which surgical resection is planned for a single metastasis and any remaining metastases are planned for stereotactic radiosurgery (srs); or an intra-operative diagnosis of metastatic brain tumor in a patient with a single brain lesion. 5. have a life expectancy of ≥12 weeks. 6. have a karnofsky performance status (kps) score of 70 or higher. 7. have recursive partitioning analysis (rpa) status of 1 or 2. 8. women of childbearing potential must have a negative serum or urine pregnancy test within 14 days of the surgical resection; and 9. patients must be able to understand english, either orally or in writing, and be able to consent and complete the required assessments and procedures. exclusion criteria: 1. are unable or unwilling to understand study assessment or to cooperate with the study procedures as determined by the investigator. 2. have a history of allergic reaction or known hypersensitivity to bcnu (carmustine) or other components of the gliadel, such as polifeprosan polymer. 3. have a history of prior cranial irradiation. 4. have a prior diagnosis of central nervous system (cns) tumor. 5. have received prior treatment for brain tumors. 6. have had prior exposure to gliadel or its components, such as polifeprosan polymer. 7. have any uncontrolled medical or psychiatric conditions which preclude them from participating in or completing the study procedures. 8. concurrent severe medical conditions include, but are not limited to, active infection, acute hepatitis, cardiac arrhythmia, unstable angina, congestive heart failure, uncontrolled diabetes mellitus, uncontrolled seizures, pulmonary insufficiency, pulmonary fibrosis, pulmonary embolus, etc. 9. have a diagnosis of tumor in the brain stem or posterior fossa. 10. have an rpa status of 3. 11. have a diagnosis of leptomeningeal disease at time of enrollment; or 12. are currently pregnant or lactating, or plan to become pregnant during the course of the study.

Keywords: gliadel
correlation analysis of xpert carba-r detection of non-colonized cre in balf and rectal swabs from patients with lrti

Conditions: Carbapenem-Resistant Enterobacteriaceae; Lower Respiratory Tract Infections

Summary: assess the correlation between xpert carba-r detection of carbapenemase gene types in bronchoalveolar lavage samples and rectal swab samples from non-colonized crkp patients with lower respiratory tract infections, and evaluate the relationship between first-time lower respiratory tract infections and intestinal colonization of crkp.


Eligibility criteria:
inclusion criteria: * aged 18 years and above * crkp is cultured from lower respiratory tract specimens in 15 days * lower respiratory tract infection based on at least two of the followings: abnormal temperature (body temperature greater than 38.5°c or less than 36.5°c), leucocyte count abnormality (leucocyte count greater than 10\*10\^9/l or less than 4\*10\^9/l), and the presence of purulent tracheal secretions. exclusion criteria: * there are other bacteria that can produce carbapenemases exist in lower respiratory tract specimens * infected with cre before
anxiety levels in adolescents undergoing endoscopy

Conditions: Anxiety

Summary: the aim of our study was to evaluate the pre-procedure state and trait anxiety levels of adolescents patients hospitalized for the purpose of gastrointestinal endoscopy performed under sedation.

although anxiety is known to be a disorder that is much more relevant for adults, it is seen at a frequency of approximately 6.5% in the childhood and adolescence. anxiety is usually examined in two different forms, state anxiety and trait anxiety. a total of 180 pediatric patients who underwent gis endoscopy in our hospital were included in our study. demographic data (age, gender, height, weight, educational status, school and grade), additional diseases and diagnoses were recorded. our aim was to evaluate the anxiety and trait anxiety levels of adolescents scheduled for gastrointestinal system (gis) endoscopy under sedation, after being admitted as a single-day inpatient and before the procedure. a form evaluating state and trait anxiety levels (spielberger's state and trait anxiety scale) and another form consisting of demographic data were given to the patients. we requested that the forms be filled by the children themselves. after monitoring in the endoscopy unit, sedation was applied with iv anesthetic drugs routinely.oxygenation was provided with nasal o2 in all patients. heart rate (hr), mean arterial pressure (map) and oxygen saturation (spo2) were monitored. also complications (bradycardia, tachycardia, arrhythmia, hypotension, hypertension, bronchospasm, decrease in spo2, apnea) were recorded.

Eligibility criteria:
inclusion criteria: * children aged 11-18 years * asa i-ii * cooperative * literate * undergoing elective endoscopic procedures exclusion criteria: * under 11 years of age * uncooperative * illiterate * had known psychiatric disorders or were using psychiatric drugs * emergency endoscopy

Keywords: adolescent anxiety endoscopy anesthesia
bladder tumor biopsy study to improve preoperative determination of stage and grade

Conditions: Bladder Cancer

Summary: to assess whether the addition of a bladder tumor biopsy improves the level of agreement between the pretreatment endoscopic impression and the final postoperative pathology determination of stage and grade in non-muscle-invasive urothelial carcinoma of the bladder.

non-invasive bladder cancer is challenging to treat because it is a condition characterized by frequent recurrences that lead to numerous invasive procedures for detection and treatment. the mainstay of therapy for non-muscle invasive bladder cancer, which has remained unchanged for decades, relies on surgical resection (tur) associated with utilization of intravesical immunotherapy and chemotherapy. despite our best efforts, these tumors continue to have suboptimal rates of recurrence and require long-term follow-up with costly and invasive procedures. the rationale for this study is to show that the preoperative biopsy, taken at the time of the office cystoscopic evaluation, improves pre-tur staging and grading correlation with the final pathology of the resection. indirectly, this will suggest that the routine use of pre-tur biopsy provides more accurate information for intraoperative decision-making that can ultimately lead to better management of these patients with non-muscle-invasive bladder cancer.

Eligibility criteria:
inclusion criteria: * male or females, age 21 or older; * clinical evidence of urothelial carcinoma of the bladder; * clinically (endoscopic, by physical examination, and/or axial-imaging) deemed non-muscle-invasive tumor of the bladder (ctis-ta-t1), of any grade, single or multiple, at initial occurrence or recurrent with \>12 months interval free of disease; * surgically eligible for the tur; * patient or authorized proxy needs to have signed the informed consent form. exclusion criteria: * history of any muscle-invasive or non-organ confined bladder tumors (t2 or higher); * patients with sessile appearing bladder tumors, which may be t2 or higher stage; * diagnosis of urothelial carcinoma involving the prostatic urethra or upper urinary tract; * concurrent use of anticoagulation medication or chronic use of nsaids, including aspirin (other than cardio protective doses of 80mg daily) that has not been appropriately interrupted before the office cystoscopic evaluation; * patient deemed medically or psychologically unfit for the surgical procedure; * subject has received any investigational medication within 30 days prior to the registration or is scheduled to receive an investigational drug during the course of the study; women exclusion * pregnant or lactating women.
the impact of a tele-exercise program for children with cystic fibrosis during the covid-19 pandemic on quality of life

Conditions: Cystic Fibrosis; Exercise Addiction; Nursing Caries; Quality of Life; Exercise Adherence

Summary: the aim of this study was to examine the effect of the tele-exercise program applied to children with cystic fibrosis in the covid-19 pandemic on the quality of life and the symptoms experienced during exercise

cystic fibrosis is a chronic, progressive, life-shortening, genetic, complex disease that affects multiple organs and systems. the care and treatment process of cystic fibrosis disease requires a multidisciplinary approach. regular exercise (as it is an important component of therapeutic treatment) improves respiratory function in children with cystic fibrosis. however, the treatment burden of the disease in the child and the serious respiratory system complications caused by the covid-19 infection during the pandemic process cause patients with cystic fibrosis to be in the high risk group. since it is thought that it is difficult for children with cystic fibrosis to exercise during the pandemic process, home exercise programs have gained importance. with the developing technology, patients are consulted remotely, training and consultancy services are provided and they can be followed continuously through phone calls and video conferences. nurses are an important part of the multidisciplinary team responsible for the protection, development and maintenance of the health of the individual in every period of life. they have assumed the roles of educator, consultant, decision-maker, therapeutic, caregiver and researcher in order to protect the quality of life of children with exercise programs and to ensure that they lead an active life. in order for nurses to make exercise a part of the lives of children with cystic fibrosis, they should determine the knowledge level, awareness and needs of children and their families, and provide adequate and effective counseling so that they can meet their individual needs.

Eligibility criteria:
inclusion criteria: * voluntary to participate in the study * getting consent from parents * being a child with cystic fibrosis between the ages of 10-18 * having no psychological health problems * no physical problems that would prevent the child from exercising" * computer/ owning a smart phone and being able to use these devices and having an internet connection at home". exclusion criteria: * not participating in the exercise regularly (at least 2 times)", * not wanting to continue working out". * not being willing to participate in the study * not being able to get consent from their parents * being under the age of 10, over the age of 18 with a diagnosis of cystic fibrosis * having a psychological health problem * having a physical problem that prevents the child from exercising * using a computer/smartphone not having and not being able to use these devices * not having an internet connection at home".
study of tg-1701, an irreversible bruton's tyrosine kinase inhibitor, in patients with b-cell malignancies

Conditions: Non Hodgkin Lymphoma; Chronic Lymphocytic Leukemia

Summary: this is a phase 1 trial to evaluate the safety, pharmacokinetics and efficacy of tg-1701, a bruton's tyrosine kinase (btk) inhibitor in patients with relapsed or refractory b-cell malignancies.

this phase i clinical trial aims to evaluate the safety of the investigational drug tg-1701 both as a single-agent and in combination with other investigational drugs, specifically ublituximab and umbralisib. as per protocol v6.0, combination therapy (tg-1701 + ublituximab + umbralisib) will be discontinued and the participants from arm 1 and 2 will be transitioned to the long-term extension period to receive tg-1701 monotherapy.

Eligibility criteria:
inclusion criteria: * relapsed or refractory histologically confirmed b-cell lymphoma or cll * eastern cooperative oncology group (ecog) score of 0 to 2 * adequate organ function exclusion criteria: * prior therapy with a btk inhibitor (ibrutinib, acalabrutinib, other) * any major surgery, chemotherapy or immunotherapy within the last 21 days * known hepatitis b virus, hepatitis c virus or hiv infection