Kornimate/medical-research-clean huggingface dataset:
defunctioning cannula ileostomy after lower anterior resection of rectal cancer

Conditions: Rectal Neoplasms

Summary: most surgeons suggest the use of fecal diverting to address the high morbidity and mortality associated with anastomotic leakage (al) in patients with high risk factors on al who are undergoing anterior resections. although debate about the use of defunctioning stoma continues, meta-analyses and randomized multicenter trial results support the use of defunctioning stoma in lower anterior resection(lar). this exploratory study was conducted to evaluate the efficacy and safety of a new diversion method called spontaneously closed cannula ileostomy (scci), which was designed to protect rectal anastomosis in patients with high risk factors on al. results of scci were compared to those of the loop ileostomy (li) method.

after low anterior resection(lar), in the li group, the operation method was done as surgeons all known. in the cannula ileostomy group, a double row of concentric purse-string sutures were placed in the ileum wall using 3-0 absorbable suture. the diameters of the purse-string rings were about 10 mm and 20 mm, respectively. the investigators then made a small incision within the inner purse-string and inserted the trachea cannula into the proximal end of the ileum. the inner purse-string suture then was tied, followed by the outer purse-string suture. the outer purse string should capsulate the inner purse string to prevent leakage. normal saline was injected into the air bag until the ileum wall began to turn pale. the investigators then pulled the cannula out through the abdominal wall. the incision site in the ileum was approximated to the inner abdominal wall and extraperitonized by fixing the mobilized ileum wall around the cannula to the inner abdominal wall. this was accomplished using 3-4 interrupted sutures. in the li group, patients accepted reversal operation at least 3 months after operation if operation condition permission. in the cannula ileostomy group, the cannula will be removed after 3-4 weeks. if anastomotic leakage occurred, the investigators will keep the cannula until the anastomotic leakage was cured.

Eligibility criteria:
inclusion criteria: 1. rectal tumor after low anterior resection the anastomosis located extraperitoneal. 2. intraperitoneal anastomosis who used of glucocorticoid or accepted neoadjuvant chemoradiotherapy. 3. patients agreed to undergo the canula ileostomy or loop ileostomy procedure exclusion criteria: 1. bowel preparation is satisfied before operation(this means that if surgeons find that there is much feces left in the colon,the patient will be excluded) 2. positive air leakage test 3. fractured anastomotic rings

Keywords: lar anastomotic leakage cannula ileostomy loop ileostomy
the impact of tele-coaching on the physical activity level

Conditions: Telemedicine

Summary: the study aims to test the benefits of a semi-automated tele-coaching program to coach adult participants with chronic lung disease towards a more active lifestyle.

the level of physical activity (pa) has been shown to be an important predictor for morbidity and mortality in individuals with chronic respiratory diseases, for instance chronic obstructive pulmonary disease (copd) or idiopathic pulmonary fibrosis (ipf). physical inactivity and sedentary behavior is a common feature of patients with chronic respiratory diseases. pulmonary rehabilitation is known as a beneficial intervention in exercise capacity, disease symptoms and quality of life in respiratory diseases. despite the overall large benefits on exercise capacity and other variables described above, it does not automatically translate into increases in pa. recent literature shows that coaching programs specifically aiming to increase pa are more likely to result in pa changes. therefore, this study was designed to investigate the impact of 3-month (12 weeks) tele-coaching intervention on pa level of adult participants suffering from a chronic lung disease.

Eligibility criteria:
inclusion criteria: * stable patients, older than 18 years of age, with a diagnosis of interstitial lung disease * understands and is able to work with a smart phone application (judged by the investigator) * on stable pharmacotherapy * diffusing capacity of the lungs for carbon monoxide (dlco) ≥30%predicted exclusion criteria: * on the waiting list for a lung transplantation * life expectancy below 3 months * respiratory tract infection or an exacerbation or change in maintenance medication within 4 weeks before study enrolment * extra pulmonary impairments, unrelated to the underlying lung disease, interfering with physical activity

Keywords: tele-coaching physical activity
scalp hair estradiol and progesterone level determination in women (proof of concept study)

Conditions: Healthy

Summary: the investigators hypothesis is that we can determine estrogen and progesterone levels in the hair by using the immune method and we can show a significant difference in the levels of these hormones in both groups of women: pre- and postmenopausal women. if indeed it would then be possible in future to carry out research that can find a relationship between the levels of these hormones and various diseases

one group will include 20 women under the age 40 years old, with regular menstruation cycles and without any illness or medication including birth control pills or steroidal ointments, and without known diagnosis of polycystic ovaries or fertility disorder. the second group will include 20 women over the age of 60, with no menstruation at least for the last five years, and without hormone therapy or treatment of any steroidal therapy for the last year. from all of the participants the investigators will collect hair samples at the crown back of the head (hair will be cut as close as possible to the scalp), the samples will be measured quantitatively about 100 hairs at a length of 2-3 cm. in order to grind the hair samples we will use a mini-bead beater machine. milled hairs will be incubated overnight in a solution of 1 ml methanol 50, in constant gentle muddling. afterwards, ethanol will disperse through a stream of nitrogen. the remainder of the suspension will be dissolved at 200 microliter buffer pbs (phosphate-buffered saline) (ph 8.0) and the concentration of estrogen and progesterone will be measured by using the immune method which is available in the endocrine laboratory in bnai zion medical center. at the end of the study the investigators will cary out a statistical comparison of progesterone and estrogen levels between the two groups.

Eligibility criteria:
inclusion criteria: * women under 40 with regular cycles * women over the age of 60 in menopause for at least 5 years exclusion criteria: * pregnant women * oral contraceptive treatment in the last year * hormonal replacement therapy in the last year * 6 month after delivery * infertile women * irregular menstruation * women with progesterone secretion intrauterine device in the last year * bmi- body mass index- below 25 or above 35 * polycystic ovarian syndrome * steriodal treatment including inhalers and ointments. * status post removal of the ovaries or uterus * breast or uterine cancer in the past. * any pituitary or adrenal disease

Keywords: postmenopausal women scalp hair estrogen progesterone
long-term outcome of patients with acute ulcerative colitis after first course of intravenous corticosteroids

Conditions: Ulcerative Colitis

Summary: all episodes of patients with acute uc admitted to tampere university hospital and treated with intravenous corticosteroids between january 2007 and january 2016 were identified from patient records and reviewed. the risks for colectomy and for continuous use of corticosteroids were evaluated. predictive factors were analysed.

data collected included epidemiological (gender, age at index flare, smoking status), clinical (uc duration, extent of the disease, prior cs usage, disease severity, laboratory results at index flare) and treatment data (occurrence of new flares, need for further cs therapy; cya, thiopurines, biologics or colectomy during follow-up). the diagnosis of uc was made on basis of clinical history, symptoms, endoscopic and histological features. disease extent was categorized by the montreal classification and the severity of the flare was assessed by mayo scoring system based on clinical and endoscopic characteristics. asuc was characterized by more than six bloody stools/day along with any of the following: tachycardia, elevated temperature, anemia and/or esr \>30 mm/h (truelove and witt´s criteria)5. alleviation of uc was defined as clinical response to intravenous corticosteroids with no need for colectomy or rescue therapy at the same hospitalization as the index flare. relapse was defined as requiring further corticosteroid treatment, rehospitalization, rescue-therapy, or colectomy later in follow-up.

Eligibility criteria:
inclusion criteria: * acute severe ulcerative colitis treated first time with iv corticosteroids * follow-up for at least six months after hospitalization or until colectomy. exlusion: -under 16 year of age

Keywords: corticosteroids, cyclosporine, colectomy, clinical outcome
cryo nerve block extremity amputation registry for post operative and phantom limb pain

Conditions: Amputation; Amputation of Lower Limb; Amputation of Upper Limb; Amputation, Limb Loss; Amputation, Traumatic/Surgery; Cryo Analgesia

Summary: the goal of this registry is to see how the device is used when freezing nerves during an amputation procedure.


Eligibility criteria:
inclusion criteria: * patients who have or will have an amputation procedure; * patients who are willing and capable of providing informed consent; * patients whose age is 18 years or above, or of legal age to give informed consent specific to state and national law. exclusion criteria: * women of childbearing potential who are, or plan to become, pregnant during the time of the study; * other medical, social, or psychological conditions that in the opinion of the investigator precludes the subject from appropriate consent or adherence to the protocol.
effect of an alternative rutf on intestinal permeability in children with severe acute malnutrition

Conditions: Malnutrition, Child

Summary: ready-to-use therapeutic food (rutf) is the standard of care for the treatment of sam. unicef requires that there be no oil separation in these products necessitating the use of emulsifiers. the effect of emulsifiers on gut health and integrity in children receiving an exclusive diet of rutf is unknown. the pis have recently completed a randomized, triple-blind, controlled, clinical equivalency trial in sierra leone comparing the alternative oat rutf (oat-rutf) to standard rutf on recovery rates in children with sam. this study demonstrated higher rates of recovery among children receiving the oat-rutf. the investigators hypothesize that this benefit may be due to the lack of emulsifier in the oat-rutf resulting in improved intestinal health.this research project is a double-blind, randomized, controlled clinical effectiveness trial comparing a novel rutf containing oats and no emulsifier and standard rutf on recovery from severe acute malnutrition (sam) and effects on intestinal health. the trial will be conducted in up to 40 phus in western rural and pujehun districts where supplementary feeding programs (sfp) are not currently available.


Eligibility criteria:
inclusion criteria: * mid-upper arm circumference (muac) \<11.5 cm exclusion criteria: * children currently involved in another research trial or feeding program * children developmentally delayed * have a chronic debilitating illness * history of peanut or milk allergy
acetabular shell positioning using patient specific instruments

Conditions: Osteoarthritis, Hip; Rheumatoid Arthritis; Avascular Necrosis

Summary: the proposed study is a double-blinded randomized controlled trial comparing patient specific instruments with solely standardized instruments and pre-operative planning used for the placement of the acetabular cup prosthesis used in total hip arthroplasty. the investigators will enroll 36 patients who have consented to total hip arthroplasty for treatment of hip pathology. this treatment is a standard of care. patients will receive standard of care pre- and post-operative care and placement of standard of care implants all of which are commercially available and fda approved for general use for the clinical indications used in these patients. all patients will receive a pre-operative ct scan for surgical planning and comparison with post-operative ct scan. the difference in intervention between the groups will be the creation and use of patient specific instruments from the pre-operative planning session. these instruments will be used for placement of an indexing peripheral guide wire to direct acetabular preparation and placement of the shell assisting standard surgical instruments. print-offs from the pre-operative plan will also be used in the treatment group. the post-operative scan will be performed within two weeks of the surgery for both the treatment and control groups. the investigators will analyze the difference in acetabular shell placement (acetabular version and abduction angle) from the pre-operatively planned ct scan. these differences will be compared between the control and experimental groups.

no further details to report.

Eligibility criteria:
inclusion criteria: subjects to be included in this protocol will be adult males and females of all races and socioeconomic status meeting the following criteria: * primary, unilateral direct lateral or posterior tha * 18 to 85 years old at time of surgery * able to get a pre- and post-operative ct scan at the cleveland clinic exclusion criteria: * the following criteria will exclude subjects from this protocol: * significant metal in the joint that results in metal artifact on the pre--operative ct scan, thereby compromising the ability to visualize the acetabulum on the pre-operative simulator. * pregnancy * incarceration * condition deemed by physician or medical staff to be non-conducive to patient's ability to complete the study, or a potential risk to the patient's health and well-being.

Keywords: total hip arthroplasty (tha) patient-specific instruments acetabular cup placement accuracy
dendrobium huoshanense suppository in rectal cancer

Conditions: Locally Advanced Rectal Cancer

Summary: to evaluates the role of dendrobium huoshanense suppository for radiation proctitis in locally advanced rectal cancer treated by capecitabine and irinotecan based neoadjuvant chemoradiation.


Eligibility criteria:
inclusion criteria: 1. pathological confirmed rectum adenocarcinoma 2. clinical stage t3-4 and/or n+ 3. the distance from anal verge less than 10 cm 4. without distance metastases 5. performance status score: 0\~1 6. without previous anti-cancer therapy 7. able to follow the protocol during the study period 8. sign the inform consen exclusion criteria: 1. pregnant or breastfeeding women 2. those with other history of malignant disease in the past 5 years, except for cured skin cancer and cervical carcinoma in situ 3. if there is an uncontrolled history of epilepsy, central nervous system disease or mental disorder, the investigator may determine that the clinical severity may hinder the signing of informed consent or affect the patient's oral medication compliance. 4. clinically severe (ie, active) heart disease, such as symptomatic coronary heart disease, new york heart association (nyha) class ii or more severe congestive heart failure or severe arrhythmia requiring medication intervention (see appendix 12), or a history of myocardial infarction in the last 12 months 5. organ transplantation requires immunosuppressive therapy severe uncontrolled recurrent infections, or other serious uncontrolled concomitant diseases 6. subject blood routine and biochemical indicators do not meet the following criteria: hemoglobin ≥ 90g / l; absolute neutrophil count (anc) ≥ 1.5 × 109 / l; alanine transaminase (alt), aspartate aminotransferase (ast) ≤ 2.5 times the upper limit of normal; alkaline phosphatase (alp) ≤2.5 times the normal upper limit; serum total bilirubin \<1.5 times the normal upper limit; serum creatinine \<1 times the normal upper limit; serum albumin ≥ 30g / l 7. anyone who is allergic to any research medication 8. dpd deficiency

Keywords: neoadjuvant chemoradiotherapy dendrobium huoshanense irinotecan capecitabine
interaction of chronic sleep restriction and circadian misalignment on sleep and neuro-cognitive performance

Conditions: Healthy

Summary: the primary objectives of the proposed experimental and modeling efforts are to quantify the influences of acute sleep deprivation (short-term homeostatic), chronic sleep restriction (long-term homeostatic), circadian rhythmicity, and their interactions on neurocognitive performance and to develop a new model of sleep homeostasis that can predict the effects of chronic sleep restriction. this model will be based on the underlying neuroanatomy and neurophysiology. this new model will facilitate optimization of human performance in operational settings, such as are seen in military operation and other work environments.

this protocol involves a baseline period consisting of 14 hours of wakefulness and 10 hour nocturnal sleep episodes each 24 hours. this is followed by a forced desynchrony regimen spanning 21 calendar days and consisting of 12 cycles ("days") of a 42.85-hour wake:bedrest schedule. in each 42.85 hour cycle, there are 32.85 hours of scheduled wakefulness and 10 hour sleep opportunities. this will allow assessment of the independent contributions of circadian phase and homeostatic sleep pressure on sleep and neurobehavioral performance. this forced desynchrony regimen is followed by 10 recovery days consisting of 14 hours of wakefulness and 10 hour nocturnal sleep episodes each 24 hours.

Eligibility criteria:
inclusion criteria: * age 18-35 years old * medically healthy exclusion criteria: * sleep disorder * psychiatric illness * chronic medical condition * no prescription or non-prescription medications

Keywords: forced desynchrony circadian rhythms sleep restriction sleep homeostasis neurobehavioral performance
glucosamine sulphate and ginkgo biloba as antifungal activity for treating tinea pedis

Conditions: Foot Infection Tinea Pedis

Summary: tinea pedis infected the feet of about 20-25% of the world population. tinea pedis is a fungal infection of the feet and it is easily spread. oral therapy is usually used for chronic conditions or when topical treatment has failed. the aim of this study is to prove the antifungal and antibacterial activity of ginko biloba (gkb) \& glucosamine (gl) as separate material or both in combination.

ginko biloba (gkb) \& glucosamine (gl) were formulated in different dosage forms such as capsules, hydrogel and spray. gkb\&gl were in filled in hard gelatin capsules as three formulae (gkb caps, gl caps and both as mixture in caps). also, gkb\&gl were formulated in hydrogel using 2% carbopol 934 as three formulae (gkb only, gl only and both as mixture). the same also were formulated as spray using alcohol, water and glycerol in concentration of 60%, 20% and 20% respectively. the study included 5 trials, involving 35 participants. the oral formulae were tried on 30 participants having tenia pedis. fluconazole was as standard antifungal drug.the antifungal activity of all gel formulae was determined by agar well-diffusion method. it is also important to follow up and collect data, preferably for six months for local and systemic activity, to establish whether or not the infection recurred or not. in future clinical trials, research should consider the costs of the different treatment approaches.

Eligibility criteria:
inclusion criteria: * it is important to follow up and collect data, preferably for six months for local and systemic activity of ginkgo biloba and glucosamine, to establish whether the infection recurrent or not. exclusion criteria: * larger numbers of participants having different kind of fungal infection are needed to test efficiency drug in order to produce more reliable data.
2d strain evaluation: children with duchenne muscular dystrophy versus healthy children

Conditions: Duchenne Muscular Dystrophy

Summary: compare systolic function of left ventricle (lv) and right ventricle (vd) by 2d strain evaluation in duchenne muscular dystrophy children versus a control group.

among the new echocardiographic techniques, two dimensional speckle tracking imaging or "2d strain" allows a dynamic study of regionalized and global ventricular contraction. with software for the spatial and temporal processing of a standard 2d image, this technique measures the displacement of natural markers present on the myocardial wall. used in adult cardiology since 2000, it could be eligible to pediatric population because of many potential applications. in duchenne muscular dystrophy, myocardial disease leads to death in the third decade. early diagnosis and preventive therapy remain a challenge. no clinic, biologic or radiologic markers can predict myocardial disease before advanced and irreversible heart failure. recent animals and human studies suggest that 2d strain anomalies could predict left ventricular systolic dysfunction in duchenne muscular dystrophy. if it is confirmed, 2d strain could be used as early marker of myocardial disease in routine patient follow-up and in future therapeutic studies. purpose : - to compare systolic function of left ventricle (lv) and right ventricle (rv) by 2d strain evaluation in duchenne muscular dystrophy children versus a control group. * to correlate 2d strain variables to conventional lv and rv echo variables. * to evaluate 2d strain feasibility in normal children and duchenne muscular myopathy population

Eligibility criteria:
inclusion criteria: * duchenne's muscular dystrophy (group 1) followed in our institution's referral center of neuromuscular diseases, during regular annual echocardiography follow-up. * healthy children (group 2), addressed in pediatric cardiology
inspiratory and trunk muscle activity during imt on stable and unstable surfaces in stroke patients

Conditions: Stroke; Inspiratory Muscle Training; Diaphragm; Sternocleidomastoid Muscles; Trunk Muscle Activity

Summary: this study aims to investigate the differences in muscle recruitment of the diaphragm (assessed using ultrasound), the sternocleidomastoid (scm) and trunk muscles (both measured via surface electromyography (semg)), during loaded breathing training performed on both stable and unstable surfaces. the goal is to understand the interaction between the inspiratory and trunk muscles during inspiratory muscle training (imt) across these two surface conditions.


Eligibility criteria:
inclusion criteria: * age ≥ 40 years and \< 80 years * breathing spontaneously * clinically diagnosed with ischemic and/or hemorrhagic stroke * stroke duration from onset between 1 and 12 months * no thoracic or abdominal surgery in the past 6 months * no cognitive impairment (montreal cognitive assessment (moca) score ≥ 26) * able to understand and follow verbal instructions * no facial palsy or only mild facial palsy without limitation of labial occlusion * able to complete all loaded breathing tests on both stable and unstable surfaces included in this study exclusion criteria: * acute myocardial infarction or acute heart failure * acute pain in any part of the body * history of chronic respiratory illness or positive clinical signs of impaired respiratory function (such as shortness of breath, hypoxemia, chronic cough, and sputum retention) * presence of a nasal feeding tube, tracheal tube, or any condition that prevents the measurement or implementation of the study procedures