Kornimate/medical-research-clean huggingface dataset:
protective effect of ripc against negative inflammatory response and organ dysfunction after cardiovascular surgery (panda vii)

Conditions: Cardiopulmonary Bypass; Cardiovascular Diseases; Inflammatory Response During Cardiac Surgery

Summary: remote ischaemic pre-conditioning (ripc) has been recognized as a low-cost, non-invasive intervention method by applying brief ischaemia and reperfusion on an arm or a leg. previous studies have mainly focused on the organoprotective effects of ripc in patients undergoing cardiac surgery. however, whether it has an organ-protecting effect is still highly debated. we aimed to determine whether intensive ripc can prevent from negative inflammatory response and organ dysfunction as well as postoperative complications in patients undergoing cardiovascular surgery.


Eligibility criteria:
inclusion criteria: * patients at high risk for organ dysfunctions who underwent elective cardiovascular surgery requiring cardiopulmonary bypass (cpb); * age of 18 -80 years old, regardless of gender; * subjects voluntarily participate in the trialand sign the informed consent; exclusion criteria: * 1) arm fracture, skin injury or infection; * 2) there is limb nerve injury; * 3) limb placement picc, arteriovenous fistula and other devices that affect armband placement; * 4) there are basic vascular lesions and poor blood supply at the extremities; * 5) limb thrombosis.

Keywords: inflammation
bone antiresorptive therapy with antiretroviral initiation (batari) pilot trial

Conditions: HIV

Summary: this is a two-site, three-arm, open-label, pilot randomized controlled trial of bone anti-resorptive therapy during art initiation in hiv-infected adults. thirty (30) treatment-naïve hiv-infected adults initiating eligible first-line art regimens will be randomized in a 1:1:1 fashion to one of the following three arms: 1. no bone anti-resorptive therapy (standard of care) 2. concomitant initiation of a 24 week course of co-formulated alendronate/vitamin d; 3. a 24 week delay in initiation of a 24 week course of alendronate/vitamin d assessments (including clinical evaluation, questionnaires, adherence, basic laboratory evaluation, and bmd measurement) will be performed at baseline, 24 and 48 weeks. the primary objective will involve calculation of σ and ρ using all data; δ will be estimated by comparing the two alendronate arms pooled to the no-treatment arm.


Eligibility criteria:
inclusion criteria: * documented hiv-1 infection * adult (aged \>18 years or as per local guidelines) * premenopausal, if female * antiretroviral-naïve * starting first-line art including tenofovir/emtricitabine with either efavirenz (co-formulated as atripla®) or elvitegravir, cobicistat (co-formulated as stribild®) * low (\<10%) ten-year fracture risk as assessed by the frax score validated for canadian populations exclusion criteria: * presence of established osteoporosis at baseline as determined by bmd measurement * prior or current use of any bone anti-resorptive therapy (eg. bisphosphonate, estrogens with the exception of oral contraceptive pills, etc.) * inability to communicate in english * creatinine clearance \<35 ml/min (using cockcroft-gault formula) * hypersensitivity to alendronate, other bisphosphonates, or any component of the formulation * hypocalcemia * abnormalities of the esophagus which delay esophageal emptying such as stricture or achalasia * inability to stand or sit upright for at least 30 minutes * pregnancy, active plans to become pregnant, or lactation

Keywords: osteoporosis hiv bone mineral density alendronate vitamin d
testing mywhi: online self-help programs for headaches

Conditions: Migraine Disorders

Summary: this randomized controlled trial will compare the effectiveness of two online self-guided programs for youth and young adults with migraine against usual care.


Eligibility criteria:
inclusion criteria: * aged 14-40 years * fluent in the english language (i.e., speaking, reading and writing); * for 14-17 year olds: suffer from headaches for a minimum of three months * for 18-40 year olds: suffer from headaches for a minimum of one year * suffer from migraine headaches as indicated with a score of 2 and above on the id migraine * have a smartphone as prism has been designed to be accessed from a smartphone and sphere encompasses the mywhi diary which has also been designed to be used from a smartphone * use the smartphone for activities other than texting and calling (e.g., email, facebook) as the programs are designed for migraineurs who are familiar with using smartphones and use them in their daily life * have daily internet access from their smartphone, because running the programs require an internet connection * minimum of four headache days during 4 weeks that they are asked to use an electronic headache diary exclusion criteria: * health care professional has not ruled out any underlying medical condition related to their headaches (e.g., head trauma, meningitis) * are pregnant, planning to get pregnant (in the next 4 to 6 months), or breastfeeding, as hormonal changes are known to exert potent influences on migraine headaches * have an impairment which compromises their ability to give informed consent * having been diagnosed with psychosis and/or schizophrenia, because a past or current diagnosis may likely interfere with the participants ability to fully participate in the study * have participated in our recent three-armed pilot rct (i.e., any participant who consented and was randomized) * they complete less than 50% of daily entries (i.e., less than 14 daily entries) in an electronic headache dairy when they asked to use it for 4 weeks * more than 15 headache days during the 4 weeks that they are asked to use an electronic headache diary
with-me - technology-aided phone coaching for occupational health study

Conditions: Psychological Stress

Summary: the purpose of this study is to examine whether the technology (web-based coaching, profiling and suggestion tool) brings added value to the traditional phone coaching in occupational health context. the interventions are phone counseling interventions. the other intervention exploits additionally a specific web-based coaching, profiling and suggestion tool.

the study focuses on mental well-being. the both interventions include intensive and independent phase. the intensive phase lasts 13 weeks. in the intensive phase, goals for the coaching are defined. coach calls the customer every two weeks and they discuss about the actions that took place in the previous two weeks and what they need to do in the next two weeks. in the technology-aided arm, customers get and analysis of their change needs via digital tool. based on the change needs they receive task/goal suggestions from which they need to choose 3. coach is able to see these choices and exploits it in the coaching. the selected behavioral activation interventions are delivered to customer utilizing a web-based coaching tool. the independent phase lasts 13 weeks. in the independent phase, technology-aided group is coached via the digital tool. the phone counseling group gets 3 phone calls.

Eligibility criteria:
inclusion criteria: * at least a bachelor level degree * age over 18 years * decreased psycho-physic state (own assessment) * is in a relationship * motivated to enhance own well-being and willing to change lifestyle, to do exercises related on mental well-being and relationship * willing to use technological wellness coaching tools, familiarity with technology exclusion criteria: * work includes night shifts * acute health conditions or serious diseases * chronical pain affecting functionality * long period(s) of absence from work during the coaching period (e.g. long vacation, alternation leave, parental leave, pension) * participation in some other study

Keywords: coaching well-being digital health profiling customer satisfaction user experience occupational health lifestyle psychological stress cost-effectiveness guideline adherence
impact of impaired cerebral autoregulation on postoperative delirium in elderly patients undergoing spine surgery

Conditions: Delirium

Summary: delirium (confusion) after surgery is common and associated with a longer hospitl stay and increased hopsital cost. there is very little information available about how often delirium occurs and the complications associated with it. elderly patients are at high risk for delirium after surgery. this research is being done to measure how often delirium after spine surgery occurs and to see if there are ways to predict if delirium will develop. the results from this study will provide important information on a possible mechanism and predictor of delirium.

delirium (confusion) after surgery is common and associated with a longer hospitl stay and increased hopsital cost. this research is being done to measure how often delirium after spine surgery occurs and to see if there are ways to predict if delirium will develop. we hypothesize that impaired cerebral autoregulation may be a possible mechanism for postoperative delirium. we will measure intraoperative cerebral autoregulation and assess the relationship with postoperative dleirium. the results from this study will provide important information on a possible mechanism and predictor of delirium.

Eligibility criteria:
inclusion criteria: 1. ≥ 70 years old, 2. undergoing any lumbar spine surgery, posterior cervical spine surgery, or anterior cervical spine surgery \> 2 levels exclusion criteria: 1. mmse \< 15 2. delirium at baseline 3. inability to speak and understand english 4. severe hearing impairment, resulting in inability to converse. 5. planned use of intraoperative ketamine 6. planned use of intraoperative remifentanil, except for airway management pre-incision. 7. arterial catheter not planned to be inserted

Keywords: delirium
the effect of kinesio taping application for dysmenorrhea

Conditions: Dysmenorrhea

Summary: dysmenorrhea is a common symptom in daily practice of gynecology. different kind of treatment strategies are being held. but invasive and pharmacological therapies have good outcome with systemic side effects. kinesio taping is being widely used in different pain conditions. kinesio taping is a noninvasive and nonpharmacological, easy-to-use intervention method which can be used in outpatient practice without systemic side effects.

dysmenorrhea is a kind of visceral pain that result of peritoneal irritation. it is so common in gynecological outpatient practice. most of treatment is based pharmacological treatments as nsaids, oral contraceptives with many side effects. kinesio taping is widely used for musculoskeletal parenchymal pain like sports related injuries. as in other complementary treatment methods like acupuncture and acupressure; pain carrying unmyelinated thin pain fibers are blocked by touch sensation carrying myelinated thick fibers which is stimulated by acupressure(gate control theory by melzack), kinesio taping blocks the pain fibers that comes from same spinal level. so it can be used easily and instantly for dismenore

Eligibility criteria:
inclusion criteria: * dysmenorrhea exclusion criteria: * pregnancy * surgical abdominal emergency * metabolic or inflammatory illnesses or cardiovascular diseases, * endocrine disorders such as diabetes, thyroid disorders, androgen excess (hyperprolactinemia, uncontrolled thyroid disease, congenital adrenal hyperplasia, cushing's syndrome, androgen-secreting tumor), * smokers * using pharmaceutical agents such as anti-inflammatory agents that could possibly impact on endocrine and liver enzymes * musculoskeletal pain * inguinal hernia

Keywords: dysmenorrhea kinesio tape
unilateral secondary breast reconstruction using a muscle-sparing pedicled dorsal flap after breast cancer

Conditions: Patient Satisfaction

Summary: the use of pedicled dorsal flaps sparing the latissimus dorsi muscle (tdap and msld flap) is a well-described reconstruction method in breast reconstruction after breast cancer. however, little data exists regarding patient satisfaction after this surgery. the main objective of this study was to evaluate patient satisfaction after unilateral total secondary breast reconstruction using a tdap or msld flap.


Eligibility criteria:
inclusion criteria: * breast reconstruction using a tdap or msld flap between january 1, 2018 and december 31, 2022 * major * non opposition * women with social security number exclusion criteria: * bilateral reconstruction * partial reconstruction * immediate reconstruction * prophylactic reconstruction * women who did'nt have a breast cancer * women who don't finish their reconstruction * women who don't want participate
atrial fibrillation ablation: radiofrequency or cryoablation?

Conditions: Atrial Fibrillation

Summary: the study aims to compare 3 techniques routinely used for paroxysmal atrial fibrillation ablation: radiofrequency catheter ablation without contact-force, radiofrequency catheter ablation with contact-force and cryoablation. the hypothesis is the non-inferiority between the 3 techniques in terms of free-from atrial fibrillation survival (primary criteria). it will also compare lenght of procedure, radioscopy time and immediate complications (secondary criteria).


Eligibility criteria:
inclusion criteria: * patients who had an atrial fibrillation for symptomatic paroxysmal atrial fibrillation, refractory to antiarrhythmic drugs, between 01/01/2014 and 30/09/2017 in chr metz-thionville exclusion criteria: * patients not willing to participate via using their medical files

Keywords: atrial fibrillation catheter ablation radiofrequency contact-force cryoablation
the effect of 360° virtual reality movies on fear and anxiety

Conditions: Fear; Anxiety; Breast Cancer; Lung Cancer; Prostate Cancer; Head and Neck Cancer; Brain Tumor

Summary: to assess the effect of web-based 360° virtual reality movies on fear and anxiety, the investigators would like to assess the patient-perceived level of fear and anxiety quantitatively, making use of several questionnaires.

in engage, a kwf samenloop voor hoop subsidized project, we have developed vr movies to reduce fear and anxiety for patients who are going to be treated at maastro. these movies are based on where most fear and anxiety are experienced and have been developed after extensive discussion with different disciplines in patient care and with agreement of the director patient care. the movies include: 1) mouldroom, 2) vmdibh mamma photons, 3) head and neck photons, 4) lung photons, 5) ct-scan, 6) prostate photons, and 7) head and neck/ neuro protons. currently, the web-based 360° movies are implemented in clinical practice and the vr glasses with the 360° movies will be used as soon as social work has decided on where to integrate the use in the care pathway.

Eligibility criteria:
inclusion criteria: * diagnosed with breast- (only vmdip), lung-, prostate-, head and neck cancer, a brain tumor. * age 18+ * being able to speak, read and write in dutch * general interview between radiation oncologist and patient (= intake) * ability to give written informed consent before the start of the study * decision talk about start of treatment must have taken place exclusion criteria: * patients who are already receiving radiotherapy treatment * pre-operative consultation for breast cancer patients * patients who have seen the vr-videos already
amt-260 gene therapy study in adults with unilateral refractory mesial temporal lobe epilepsy

Conditions: Mesial Temporal Lobe Epilepsy

Summary: the main goals of this clinical study are to learn if amt-260 is safe and tolerable and works to reduce the frequency of seizures in adults with unilateral mesial temporal lobe epilepsy (mtle).

in this first clinical study of amt-260, two dose levels will be studied to find the best dose of amt-260. all eligible participants will receive amt-260 at one of the two dose levels (i.e., there is no placebo in this study). amt-260 is intended for a one-time administration, without the need to remove or destroy any part of the brain. participation in this study would not prevent later pursuit of other treatment options. participants will be monitored through study site visits, telephone calls, blood tests, and questionnaires about how their seizures affect daily life. participants will record seizures using an electronic seizure diary.

Eligibility criteria:
inclusion criteria: * diagnosis of unilateral refractory mtle * history of seizures with an average of ≥ 2 documented focal impaired awareness seizures or focal to bilateral tonic-clonic seizures per 30-day period in the 3 months prior to screening. * on a stable type and dose regimen of up to a maximum of 4 approved anti seizure drugs for at least 6 months prior to screening. * confirmed unilateral hippocampal pathology and concordant unilateral seizure focus * no evidence of focal neurocognitive dysfunction, inconsistent with disease pathology- related mri and/or (18f)fdg-pet findings. * women of childbearing potential (wocbp) and fertile male subjects must be willing and able to use highly effective methods of birth control consistently and correctly throughout the study. * for wocbp only: negative pregnancy test. exclusion criteria: * implanted devices that would contraindicate mri; mri-compatible devices must be implanted ≥3 months prior to screening (vagus nerve stimulation devices will be up to discretion of the investigator). * any other contraindications for generalized anesthesia or surgery. * medications that could confound clinical (e.g., antipsychotic medication and anti-viral therapy) and laboratory evaluations or could affect a participant's safety or their ability to undergo the neurosurgical procedure or comply with the procedures and study visit schedule. * any seizures with contralateral or extra-temporal ictal onset captured on eeg. * dementia or other progressive neurological disorders and progressive brain lesions. * previous major disease-unrelated neurosurgical intervention due to intracranial tumor, trauma, or bleeding and/or history of previous intracranial surgery for treatment of epileptic seizures, not including diagnostic stereo-eeg. * magnetic resonance imaging evidence of epileptogenic, extra-temporal lesions, or dual temporal lobe pathology.

Keywords: epilepsy temporal lobe hippocampal sclerosis epileptic syndromes
primary aldosteronism in malaysia: a nationwide multicentre study

Conditions: Primary Aldosteronism

Summary: this research focuses on the prevalence of primary aldosteronism in the malaysian adult population.

hypertension (hpt) is a very common disease, expensive to treat with serious morbidity and mortality. in malaysia, from the nhms iii conducted in 2006, hpt affects more than 36% of adults. essential hpt (hpt with no identifiable cause) accounts for approximately 85% of cases, whereas 15% have identifiable conditions (secondary cause). the detection of a secondary cause of hpt is important as the condition is reversible when detected early. primary aldosteronism (pa) has been identified as the commonest cause of secondary hpt. at present, pa has been regarded as the commonest and potentially curable, with a prevalence of 5-13% \[1-7\]. if this condition is detected early, the chances of cure from hypertension have been reported up to 80% of cases. this will translate to a major impact to the malaysian health-care budget. the costs spent on life-long bp medications and complications related to hpt can be reduced enormously. pa is a type of hormonal disorder that leads to high blood pressure (bp). in pa, the adrenal glands produce too much aldosterone causing sodium retention and potassium excretion. the excess sodium then increased the blood volume and bp. diagnosis and treatment of this condition are of paramount importance because people with this form of high bp have a higher risk of heart attack, stroke, kidney impairment, metabolic abnormality and reduce quality of life compared to patients with high bp not due to this condition. more importantly, the high bp associated with pa may be curable. this research will be conducted as a multicenter nation-wide study in malaysia. the research aimed to study the prevalence of this disease in the investigators malaysian population, determine the underlying mechanisms why this disease is associated with higher complication rate through cardiovascular and inflammatory markers, and identify the genes causing this disease, hence provide a more rapid diagnostic test and possibility of curing the disease with genetic therapy

Eligibility criteria:
inclusion criteria: * 18 years old and above * malaysian citizen * consent given exclusion criteria: * those who refused consent

Keywords: primary aldosteronism hyperaldosteronism
prevalence of inadvertent hyperventilation during intraoperative anesthetic care

Conditions: Spinal Fusion

Summary: this is a retrospective chart review of patients undergoing spinal fusion surgery to see the prevalence of hyperventilation.

retrospective review of the operative schedules to identify patients who have undergone spinal fusion with placement of an arterial cannula for intermittent arterial blood gas analysis. the intraoperative records will be retrospectively reviewed. the following demographic data will be recorded: age, weight, gender, and co-morbid medical conditions. ventilatory parameters at the time of abg analysis will include (respiratory rate and tidal volume). abg data will be collected.

Eligibility criteria:
inclusion criteria: * patients who underwent complex surgical procedures (spinal fusions) which necessitated arterial line placement and intermittent arterial blood gas analysis exclusion criteria: * none
ritonavir-boosted gs-9137 vs. ritonavir-boosted protease inhibitor(s) in combination with background art.

Conditions: HIV; HIV-1; Human Immunodeficiency Virus

Summary: the purpose of this study is to evaluate the non-inferiority of ritonavir-boosted gs-9137 relative to a ritonavir-boosted comparator protease inhibitor when used as part of combination antiretroviral regimens in subjects who have failed, or are failing, protease inhibitor therapy.


Eligibility criteria:
inclusion criteria: * hiv rna greater than or equal to 1000 c/ml. * failed/failing protease inhibitor based antiretroviral therapy. * stable antiretroviral therapy for greater than or equal to 30 days prior to screening. * negative serum pregnancy test. * gfr by cockcroft gault greater than or equal to 80 ml/min. * ast \& alt less than or equal to 2.5x uln. * total bilirubin less than or equal to 1.5 mg/dl. * albumin greater than 3.5 mg/dl. * prothrombin time inr 1.0-1.4 * platelets greater than or equal to 50,000. * hemoglobin greater than or equal to 8.0 mg/dl. * absolute neutrophil count greater than or equal to 1000. exclusion criteria: * new aids defining condition within 30 days of baseline. * prior treatment with hiv-1 integrase inhibitor (except patients from 183-101). * ascites or encephalopathy. * breast feeding. * cancer diagnosis (besides kaposi sarcoma or basal cell carcinoma).

Keywords: phase 2 phase ii randomized controlled comparator partially blind protease inhibitors integrase inhibitors antiviral agents antiretroviral agents art arv highly activity antiretroviral therapy haart treatment experienced