Kornimate/medical-research-clean huggingface dataset:
hyperbaric oxygen therapy for comatose patients with acute carbon monoxide poisoning

Conditions: Carbon Monoxide Poisoning

Summary: carbon monoxide poisoning still places a burden on the healthcare system worldwide. while oxygen therapy is the cornerstone treatment, the role and practical modalities of hyperbaric oxygen therapy (hbo) remain controversial. this study aimed at comparing two sessions of hbo at 2 absolute atmosphere and one session of hbo at 2 absolute atmosphere followed by 4 hours of normobaric oxygen therapy in comatose adult victims of acute domestic carbon monoxide poisoning.


Eligibility criteria:
inclusion criteria: * patients older than 15 years of age * admitted for domestic co poisoning within 12 hours after the end of co exposure * initial coma, regardless of consciousness at hospital admission * carboxyhemoglobin level at presentation greater than 10% or 5%, in smokers and non-smokers, respectively exclusion criteria: * poisoning by more than one compound (e.g., co plus a drug or co plus other toxic gases such as those found in fire smoke) * suicide attempt * pregnancy * contraindications to hbo (circulatory collapse or pneumothorax) * technical obstacles to hbo * non domestic co poisoning * difficulty in determining whether the patient experienced initial loss of consciousness or initial coma * consent refusal

Keywords: domestic accident coma carbon monoxide intoxication acute domestic carbon monoxide poisoning
non-invasive detection of male infertility with fdg-pet/mri (spectroscopy and dwi)

Conditions: Fertility Disorders

Summary: the aim of the study is to examine the value of the new mri techniques (spectroscopy and dwi), and fdg-pet in prognostication of male infertility.

the diagnostic workup of male infertility includes medical history, physical examination and semen analysis. in severe cases further workup includes testicular ultrasound, analysis of genes and hormones and in a few cases testicular biopsies are necessary. ultrasound is the first choice of imaging, but new mri and pet techniques can provide additional information. research indicates that new mri techniques can measure the activity of the testicular sperm cell production non-invasively and fdg-pet can measure the testicular metabolism with a radioactively marked glucose analog (fdg). these imaging modalities are combined in a pet/mri and we wish to perform a pet/mri in 10 men with normal sperm counts and 10 men with low sperm counts in order to evaluate whether a pet/mri can distinguish testicles with and without sperm cell production. we hope that this new non-invasive technique can replace the need for invasive biopsies and will be able to target the harvesting of sperm cells in fertility treatment.

Eligibility criteria:
inclusion criteria: 18-40 year old males referred to fertility treatment at rigshospitalet, denmark. 10 men with a normal sperm count and 10 men with no sperm cells in the ejaculate will be included. the patients shall be able to understand the patient information and be able to give informed consent. exclusion criteria: severe claustrophobia age: less than 18 or above 40 severe obesity (\> 140 kg) pacemaker or other electronic in-operated devices non-mr compatible metallic devices malignant testicular tumors suspected at clinical examination or ultrasound infectious testicular diseases
influence of persistent cmv-infection on immune senescence

Conditions: Immune Senescence

Summary: recent studies indicate that persistent viral infections particularly with cytomegalovirus (cmv) might have a negative impact on immune senescence (i.e. immunocompetence of elderly individuals). we will test this hypothesis by performing a vaccination trial in healthy elderly individuals subdivided in two groups of cmv-seropositive and cmv-seronegative individuals. all individuals will be vaccinated with the currently licensed vaccine for the prevention of tbe (fsme immun cc) which is recommended for the general population in our area. vaccination efficacy will be monitored longitudinally concerning the tbev-specific antibody (tbev-neutralization, tbev-specific elisa) and t cell response (elispot, cytokine production). vaccination efficacy will be compared between cmv+ and cmv- individuals and correlated with the cmv-specific immune response in cmv+ individuals.


Eligibility criteria:
inclusion criteria: * age \> 70 years * healthy according to a health questionnaire (completed before screening) * tbe-vaccination indicated (exposure to tbev-infested ticks possible) * capable to make an informed decision and to understand the informed consent form * informed consent signed by patient and study physician exclusion criteria: * previous exposure to tbev (natural or vaccination) * immunodeficiency, history of autoimmune disease or current intake of immune-modulating drugs (corticosteroids a.s.o.) * persistent (\> 3 months) pharmacological treatment with more than one drug of relevance (exception: combination antihypertensives) * contraindication for tbev-vaccination * condition that would drastically interfere with clinic attendance and/or adherence to the protocol * past medical history or current treatment for one of the following conditions: chronic cardiac disease (coronary heart disease, heart failure), chronic pulmonary disease (copd), chronic kidney disease, diabetes mellitus, previous stroke, epilepsy, parkinsons disease, dementia * hemoglobin \<12 g/l * random plasma glucose (rpg) \> 11.1 mmol/l or fasting plasma glucose (fpg) \> 6.9 mmol/l (fpg required, if rpg is 7.0-11.0 mmol/l) * calculated creatinin-clearance \< 50 ml/min * tbev-serology positive

Keywords: cytomegalovirus (cmv) tick-borne encephalitis virus (tbev) ageing vaccine immunity
serum igf-ii and cancer: can igf ii levels be used to monitor and screen patients specifically for cervical cancer

Conditions: Cervical Cancer; Cervical Intraepithelial Neoplasia II; Cervical Intraepithelial Neoplasia III

Summary: the purpose of this study is to determine whether insulin-like growth factor ii is elevated sufficiently to detect cervical intraepithelial neoplasia ii (cin ii), cervical intraepithelial neoplasia iii (cin iii), and cervical cancer.


Eligibility criteria:
inclusion criteria: * age 18 - 75 years * female * normal medical history * medical history of a single type of cancer confirmed by biopsy or equivalent criteria * squamous cell carcinoma of organs other than cervix * adenocarcinoma * medical history of inflammatory disease * may be pregnant * pap smear positive for cervical intraepithelial neoplasia ii or iii * squamous cell cervical cancer confirmed by biopsy * informed consent * willingness to submit a blood sample by venipuncture * willingness to submit a second blood sample if necessary exclusion criteria: * age \ 75 years * medical history of cancer other than cervical cancer, non-islet-cell tumor hypoglycemia, growth hormone deficiency, acromegaly, hepatoma, inflammatory disease in addition to confirmed cin and cervical cancer

Keywords: igf-ii levels
recalcitrant pruritus in cutaneous t-cell lymphoma

Conditions: Cutaneous T-Cell Lymphoma

Summary: the purpose of this study is to define the mechanisms that underlie the refractory pruritus (itch) in cutaneous t-cell lymphoma (ctcl).

little is known about the fundamental cause of pruritus in ctcl, however we do know the malignant cd4+ t-cells of ctcl accumulate in the epidermis and are in close proximity to the neural, immune and vascular systems that influence and regulate the biology of the skin. the close proximity of malignant cd4+ t-cells with the key mediators in the itch process could result in the pruritus experienced by patients with ctcl. to accomplish this we are collecting and examining skin biopsies for ctcl patients and healthy controls to identify itch-associated local biomarkers of the disease. in addition to these skin biopsies, we are retrospectively examining existing paraffin-embedded skin biopsy tissue blocks from ctcl patients. we are performing comparative and quantitative immunohistochemical analyses on the samples. this study will help to determine which components in the skin are potential key players in the manifestation and maintenance of recalcitrant pruritus in patients with ctcl.

Eligibility criteria:
inclusion criteria: * patients with ctcl exclusion criteria: * none

Keywords: pruritis itch ctcl
comparison of maitland oscillatory mobilizations with kaltenborn sustained stretch mobilizations in cervicogenic headache patients

Conditions: Cervicogenic Headache

Summary: cervicogenic headache is a common headache that causes disability and affects everyday activities. headache related disorders are the second most common reason for years lived with disability all over the world. according to the latest international headache society model, cervicogenicheadache (cgh) is a secondary headache having c1-c2 dysfunction. there is marked limitation in cervical rom specially rotation. treatment indicated involves use of electrotherapy and thermal modalities. in addition, use of different manual therapy techniques are advocated to eliminate the root cause i.e. c1-c2 dysfunction. maitland mobilizations for cervical spine have been found to be effective in treating cgh patients. maitland mobilizations uses oscillatory mobilizations and has four grades. kaltenborn, on the other hand, applies sustained stretches and has 3 grades.so, the study will be focusing on comparing the effectiveness of these two mobilizations on cervicogenic headache patients.


Eligibility criteria:
inclusion criteria: * age 18-45 years * both males and females * unilateral headache with no shift of side * c1-c2 dysfunction * headache with neck stiffness * headache at least once a month in the last 3 months * positive flexion rotation test (rotation restriction is greater than 10 degrees) * headache with a score of at least 4 in the numeric pain rating scale exclusion criteria: * cervical spondylosis * headache of non-cervical origin * dizziness or visual disturbance * cervical radiculopathy/ nerve root involvement/ disc herniation * cervical instability/ fracture * vertebrobasilar insufficiency * thoracic outlet syndrome * cervical spine surgery * cervical spondylolisthesis * spinal infection or tumors * osteoporosis * history of trauma * metabolic disorders * rheumatoid arthritis * inflammatory arthritis
cosmetic and functional sequelae in hand burns.

Conditions: Hand Burn

Summary: although it represents a small percentage of the body surface, the hand is the most exposed part of the body after the face and neck and is one of the area's most frequently involved in burns. it has a social function, but above all, a functionnal one. an optimized reconstruction of this area after the burn allow the patient to recover the best possible function and increase his chances of returning to professional activity and daily life. advances in burn treatment, such as improved resuscitation management, rapid excision of burns, skin grafting, regular dressings, and improved metabolic support, have reduced the morbidity and mortality of severe burns. however, significant challenges remain. the hand is the most frequently involved area in burns and is affected in 90% of severe burns. hand burns requiring releasing incisions are circular, deep burns and represent a significant functional challenge. in the acute setting, current treatment options must prevent complications associated with disruption of the skin's protective function. in the longer term, these treatments should allow the regeneration of fully functional skin. however, some sequelae may persist in the form of sensory deficits, residual pain, retractile scars hindering function in this highly mobile area, or even aesthetic sequelae. the aim of our study was to perform a descriptive analysis of the aesthetic and functional sequelae related to hand burns that required acute realeasing incisions using objective and subjective tools available in the medical records (demographic, clinical and follow-up data in the context of routine care). this retrospective, non-interventional, data-driven study would provide an overview of the sequelae of hand burns with current therapies.


Eligibility criteria:
* inclusion criteria : * adult patients * acute burn (less than 3 days) * burns of one or both hands or finger burns * skin surface burned less than 40% of the body * chemical, thermal, or electrical burns of the hand. * burn that required a skin graft. * exclusion criteria : * patient refusal * less than 1 month follow-up or death within the first month

Keywords: burns hands functional outcomes skin graft releasing incisions
the effect of early cow's milk elimination diet on the growth pattern

Conditions: Cow Milk Allergy

Summary: this study aimed to survey the growth of children who were on elimination diet due to cow milk allergy in turkey. 0-5 year aged children diagnosed with cow's milk allergy (cma) and healthy age-sex-matched children as the control group was planned for inclusion. participants will be included in the study by consecutive sampling. the anthropometry measurements (height-for-age \[hfa\], weight-for-age \[wfa\], and weight-for-height \[wtht\]) will be evaluated according to the z-score using the who anthro \[z-score = patient's value - average value / standard deviation (sd)\]. the z-score (sds) in the average child by age was "0".

0-5 year aged children diagnosed with cow's milk allergy (cma) and healthy age-sex-matched children as the control group was planned for inclusion. the study will constitute of two groups; group 1; the children who received cow's milk elimination (cme) diet and group 2; the healthy controls. group 1 will constitute of children aged 0-5 years who received a cme diet due to cma (ig e-mediated and/or non-ig e-mediated and/or mixed type)\], confirmed by an oral food challenge test (ofc) and had reintroduced cow's milk for at least ≥ three months ago. participants will be included in the study by consecutive sampling. the anthropometric measurements (height-for-age \[hfa\], weight-for-age \[wfa\], and weight-for-height \[wtht\]) will be evaluated according to the z-score using the who anthro \[z-score = patient's value - average value / standard deviation (sd)\]. the z-score (sds) in the average child by age was "0".

Eligibility criteria:
study group inclusion criteria: * had a diagnosis of cma by ofc, except children with known anaphylaxis * those on a cme diet or a specialized infant formula for at least three months * had reintroduced cow's milk for at least three months ago. * children who excluded other foods in addition to cows' milk in the first four years of life for ≥ three months and who currently introduced these foods for at least ≥ three months were also enrolled in the cme group. healthy group inclusion criteria: * did not have cma and other allergic diseases * who had never been on a diet throughout their lives. exclusion criteria: * known acute (e.g., influenza) or chronic (e.g., diabetes, immune deficiencies ) diseases, * history of systemic steroid use \> 0.5 mg/kg for more than one week in their life, * recurrent infections within the last three months, * food restriction other than food allergy (e.g., vegan, vegetarian), * moderate to severe asthma, and other medical or surgical conditions which might affect nutrition and growth.

Keywords: cow milk allergy elimination diet anthropometry growth status
chronic myelod leukemia registry at asan medical center

Conditions: Leukemia, Chronic Myeloid; Myeloid Leukemia, Chronic, Accelerated Phase; Myeloid Leukemia, Chronic, Chronic Phase

Summary: the investigators would like to propose a prospective longitudinal observational cohort study for patients who will be diagnosed and/or treated for chronic myeloid leukemia at asan medical center, seoul, korea, to use the acquired data for fundamentals of other retrospective analysis.

1. acquisition of informed concent form 2. data acquisition from medical record including * demographic / disease-associated factors * details of treatment, and its results * complications during treatment * genetic data * survival outcome (upto 30 years) 3. accumulation of data for 30 years 4. use of data for other retrospective analysis (including asan medical center cell banking basic data)

Eligibility criteria:
inclusion criteria: * all patients who are diagnosed and/or treated as chronic myeloid leukemia at asan medical center * 15 years of age and over * all patients who give written consent according to guidelines at asan medical center committee on human research exclusion criteria: * patients who refuse to give consent to registering
effect of modified poco-poco exercise to frailty stages, expression of global dna methylation, gdf15 and lamin a cop

Conditions: Frail Elderly

Summary: the goal of this clinical trial is to know the effect of multicomponent exercise in frail elderly in community to aging hallmarks. the main question\[s\] it aims to answer are: 1. do global dna methylation levels change in elderly people in bandung after receiving modified poco-poco exercise? 2. do gdf15 levels change in elderly people in bandung after they are given modified poco-poco exercise? 3. do lamin a cop levels change in elderly people in bandung after they are given modified poco-poco exercise? 4. does the level of frailty in elderly people in bandung change after they are given modified poco-poco exercise? participants will be asked to do flexibility, balance, aerobic and strengthening exercise included in poco-poco modified exercise three times a week for 12 weeks

the elderly population in west java province with the age category of 60-64 years is 1.76 million people. experts estimate that 25.2% of the indonesian population experiences frailty. frailty can lead to a variety of worsening health conditions. the frailty process is thought to stem from the failure of various mechanisms associated with markers of aging. markers of aging are divided into three categories: primary, antagonistic and integrative. biomarkers representing these three categories are global dna methylation, gdf15 and lamin a cop. multicomponent exercise is the most effective intervention in elderly with frailty. elderly people in west java on average only have an education equivalent to junior high school (smp), so activities that promote physical activity are better focused on health activities in the community. the poco-poco exercise that is currently commonly practiced almost fulfills the rules of multicomponent exercise for frailty elderly, but poco-poco exercise does not have a muscle strengthening exercise component, so a modified poco-pcoco exercise was created to fulfill this method.

Eligibility criteria:
inclusion criteria: 1. frailty level is in pre-frailty 2. moca ina score above 18 3. domicile in bandung city 4. willing to participate in the study after informed consent exclusion criteria: 1. there is a hearing impairment that may prevent the subject from receiving verbal instructions 2. there is uncorrected visual impairment 3. there are musculoskeletal disorders so that they cannot perform exercise procedures or procedures for measuring research variables 4. subjects received other rehabilitation programs 5. post-stroke with average limb muscle strength below three 6. there are diseases that cause impaired cognition such as alzheimer\&#39;s disease, traumatic head injury, parkinson\&#39;s disease. 7. there are severe joint diseases such as osteoarthritis and rheumatoid arthritis that may worsen during exercise or may cause difficulty in carrying out the exercise program. 8. severe cardiovascular disease as assessed by a heart and vascular specialist 9. unable to attend exercises regularly
hta of nivats based on rwe

Conditions: Lung Cancer

Summary: this research focuses on a health technology assessment (hta) of non-intubated video-assisted thoracic surgery (vats) for lung nodules. lung cancer, one of the most prevalent malignancies globally, has a high incidence and mortality rate, particularly in china. traditional treatments like thoracotomy are highly invasive, while conventional thoracoscopic surgery can induce anesthesia-related complications. non-intubated vats offers a promising alternative by avoiding intubation and mechanical ventilation, thus reducing complications, anesthesia burden, and recovery time. the study aims to comprehensively assess the clinical effectiveness, safety, and economic viability of non-intubated vats for lung cancer treatment through systematic literature reviews, real-world evidence (rwe), and cost-effectiveness analysis. the research will also explore patient preferences using discrete choice experiments (dce). by evaluating this technology from a chinese perspective, the study seeks to provide evidence-based recommendations for the broader adoption of non-intubated vats in clinical settings.


Eligibility criteria:
inclusion criteria: - experimental group (non-intubated video-assisted thoracic surgery)： 1. patients diagnosed with pulmonary nodules or lung cancer who are scheduled for minimally invasive surgery (including wedge resection, segmentectomy, or lobectomy). 2. aged between 18 and 75 years, regardless of gender. 3. preoperative assessment indicates that the patient can tolerate non-intubated video-assisted thoracic surgery. 4. the patient has signed an informed consent form and voluntarily agrees to participate in the study. control group (intubated video-assisted thoracic surgery)： 1. patients diagnosed with pulmonary nodules or lung cancer who are scheduled for minimally invasive surgery (including wedge resection, segmentectomy, or lobectomy). 2. aged between 18 and 75 years, regardless of gender. 3. preoperative assessment indicates that the patient can tolerate minimally invasive surgery. 4. the patient has signed an informed consent form and voluntarily agrees to participate in the study. exclusion criteria: 1. patients unable to provide sufficient preoperative and postoperative follow-up data. 2. pregnant or breastfeeding women. 3. patients with severe cardiopulmonary dysfunction preoperatively, making them unfit for surgery. 4. patients who have previously undergone surgery or radiotherapy in the same chest region. 5. patients with active infections or other severe comorbidities that may affect surgical outcomes. 6. patients with mental illness or cognitive impairment who cannot understand the study content or comply with follow-up requirements.

Keywords: lung cancer; pulmonary nodule; vats