Kornimate/medical-research-clean huggingface dataset:
normative values for the german version of the montreal cognitive assessment (moca)

Conditions: Cognitive Impairment; Cognitive Decline; Cognition Disorders; Cognitive Symptom; Cognitive Change; Cognitive Deterioration; Cognitive Abnormality; Cognitive Impairment, Mild; Cognition Disorders in Old Age; Dementia; Dementia Alzheimers; Dementia, Alzheimer Type; Dementia, Mild; Dementia of Alzheimer Type

Summary: this observational cohort study in healthy volunteers establishes normative data for the german version of the montreal cognitive assessment (moca) and investigates the possible impacts of demographics on the moca total score.

the montreal cognitive assessment (moca) is a short tool to evaluate a multitude of cognitive domains (visuospatial / executive functioning, object naming, memory, attention, language, abstraction, orientation). the original english moca consistently showed very high sensitivity and specificity in distinguishing patients with mild cognitive impairment from healthy controls. therefore it is an excellent tool for early recognition of cognitive disorders. based on a canadian sample, the moca proposes a cut-off-value of 26/30 points. however, there is increasing evidence of intercultural differences in terms of the best cut-off-score. in addition the original version only slightly corrects for possible influences of education - an adjustment for age- or gender-related effects is missing. therefore, the aim of our study was to investigate the possible impacts of demographics on the moca total score and to provide normative values for a german-speaking population.

Eligibility criteria:
inclusion criteria: * age ≥65 years * education ≥7 years * fluency in the german language * written informed consent exclusion criteria: * history of cognitive impairment * depression * severe sensory or motor impairment interfering with cognitive testing * serious somatic disease * disease or event affecting the central nervous system * cerebrovascular disease * regular medication with psychoactive drugs except for benzodiazepines * participation in a cognitive study within the last 3 months
pilot testing a pregnancy decision making tool for women with spinal cord injury (sci)

Conditions: Spinal Cord Injuries; Pregnancy Related

Summary: the purpose of this project is to pilot test a decision-making tool that is tailored for women with sci to support them in the decision-making process. pilot testing focuses on feasibility and preliminary efficacy.

the purpose of this project is to pilot test a decision-making tool that is tailored for women with sci to support them in the decision-making process. pilot testing focuses on feasibility and preliminary efficacy.

Eligibility criteria:
inclusion criteria: * spinal cord injury (traumatic or non-traumatic) * need for assistance with daily life activities and/or personal care; women with mild, moderate or severe severity will be eligible * actively planning or in the process of making a decision about whether or not to get pregnant in the near future exclusion criteria: - no plans for getting pregnant

Keywords: decision tool
cytosponge™ for post-chemoradiation surveillance of oesophageal cancer

Conditions: Oesophageal Cancer

Summary: this is a feasibility study testing the use of the cytosponge™ device in patients with known oesophageal cancer treated with pre-operative or definitive chemoradiation. all participants will receive one cytosponge™ procedure at one time-point within 4-16 weeks after completion of chemoradiotherapy.

in this feasibility study, we are investigating a novel way to test for remaining or reoccurring oesophageal cancer following chemoradiotherapy. the technique used to test this is called a cytosponge™. we will be testing the use of the cytosponge™ to determine completion rate, safety and acceptability of the procedure. cytosponge™ is a capsule-sized device which contains an expandable, spherical mesh which is attached to a string. the capsule dissolves in the stomach after swallowing, releasing the sponge which is then retrieved by gently pulling the string after five minutes. as the sponge is pulled out it collects the cells from the lining of the gullet. the cytosponge™ will be processed for evidence of residual cancer through analysis of cellular atypia and molecular biomarkers. where available, the results will be compared with histology. up to fifty patients will be recruited to the trial across 11 sites.

Eligibility criteria:
inclusion criteria: 1. male or female, age \>/=16 years who 1. have undergone pre-operative crt as treatment for oesophageal cancer and due to undergo oesophagectomy or 2. have undergone definitive crt as treatment for oesophageal cancer 2. 4-16 weeks post completion of crt 3. dysphagia score 0-2 (mellow scale)\* 4. able to swallow tablets 5. physiologically fit for endoscopy 6. written (signed and dated) informed consent 7. the patient is willing and able to comply with the protocol for the duration of the study, and scheduled follow-up visits and examinations. exclusion criteria: 1. known to have oesophageal varices or stricture requiring dilatation of the oesophagus. 2. unable to temporarily discontinue anticoagulation therapy/medication prior to their procedure\* 3. oesophageal stent 4. other psychological, social or medical condition, physical examination finding or a laboratory abnormality that the investigator considers would make the patient a poor study candidate or could interfere with protocol compliance or the interpretation of study results. * patients on anti-coagulation therapy are eligible for the study as long as they are considered suitable candidates for endoscopic biopsy (follow local hospital procedures for management of patients on anticoagulation due to undergo endoscopy). if temporary discontinuation of anticoagulation is required, this should be after consultation with the patients clinical care team.

Keywords: cancer oesophageal cancer gastrointestinal
cataract monitored anesthesia care (mac) feasibility pilot study

Conditions: Cataract; Bilateral Senile Cataract; Anesthesia; Patient Satisfaction

Summary: the goal of this pilot clinical trial comparing two different sedation approaches for cataract surgery is to assess patient satisfaction, the quality of recovery, and surgical outcomes as well as to evaluate the overall feasibility and acceptability of the study protocol for the purpose of planning a larger clinical trial. participants will be asked to respond to several surveys throughout the study on their experience and to assess outcomes of interest.

this is a single-center, randomized, double-blinded, pilot clinical trial (n=20). participants having first eye cataract surgery will be randomized to receive an oral benzodiazepine (intervention) or an oral placebo pill (control). the primary goal of this study is to compare differences in patient satisfaction, quality of recovery and surgical outcomes in participants receiving oral sedation versus oral placebo for cataract surgery. the secondary goals of this study are to assess success with recruitment, intervention fidelity, adherence to interventions and participant retention after interventions. participants will be asked to respond to several surveys at key study timepoints regarding their sedation experiences and to assess outcomes of interest.

Eligibility criteria:
inclusion criteria: 1. ≥ 60 years old 2. capable of providing informed consent and completing the study procedures in english 3. able to provide consent for oneself 4. able to follow directions 5. able to climb one flight of stairs without stopping to rest 6. have a new diagnosis of cataract disease 7. plan on having cataract surgery on their eye within the next 6 months exclusion criteria: 1. history of prior cataract surgery 2. admission to the hospital within the past 30 days 3. difficulty being sedated during other minor outpatient procedures or imaging studies 4. allergy or resistance to local anesthetic agents 5. cannot lay flat on your back without having symptoms (i.e., difficulty breathing, severe back pain, etc.) 6. history of severe anxiety requiring routine use of benzodiazepines 7. severe valve disease (e.g., critical aortic stenosis) 8. cardiac conditions requiring an implanted cardiac device such as a pacemaker, defibrillator, or left ventricular assist device (for arrhythmia, congestive heart failure, etc.) 9. untreated chest pain or angina 10. patients with movement disorders (e.g., parkinson's disease) 11. history of cerebral vascular accident (cva), transient ischemic attack (tia), or seizures 12. require home oxygen (o2) at rest or with exertion 13. end-stage renal disease (esrd) requiring dialysis 14. morbid obesity (bmi\>35) 15. patient undergoing cataract surgery in combination with any other ophthalmologic procedure 16. patient requiring general anesthesia during cataract surgery due to the underlying characteristics of the existing cataract and/or anticipated complexity of the planned procedure

Keywords: cataract surgery oral sedation intravenous sedation conscious sedation monitored anesthesia care quality of recovery
aseptic meningoencephalitis in slovenia

Conditions: Aseptic Meningitis

Summary: the main objective of this study is: * to establish etiology of acute aseptic meningitis/meningoencephalitis in slovenia * to assess the clinical course and outcome of tick-borne encephalitis and lyme neuroborreliosis * to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with tick-borne encephalitis and lyme neuroborreliosis


Eligibility criteria:
inclusion criteria: * clinical picture compatible with aseptic meningitis/meningoencephalitis * age 18 years or older * clear cerebrospinal fluid on macroscopic examination * cerebrospinal pleocytosis (\> 5 x 106 white blood cells per liter) exclusion criteria: * younger than 18 years * pregnant women

Keywords: aseptic meningitis tick-borne encephalitis lyme neuroborreliosis inflammation outcome
addressing systemic health disparities in early identification and treatment of autism spectrum disorder (asd): abcd project

Conditions: Autism Spectrum Disorder

Summary: the intervention under examination is designed to promote parents' school engagement following the transition from early intervention (ei) to preschool for parents of young children who were diagnosed with asd through our screening and assessment protocol. the brief intervention employs principles of motivational interviewing to address not only the particular child characteristics and needs associated with asd but also the unique, system-related challenges of navigating the special education system and advocating for appropriate services. motivational interventions with parents are designed to elicit parents' specific, action-oriented goals for themselves and their children, enhancing motivation to pursue change, and addressing and resolving obstacles or sources of ambivalence. by identifying and capitalizing on parents' strengths, empowering parents to develop specific goals, and improving parents' readiness to engage actively with their children's school, teacher, and educational team, we expect that this brief intervention will lead to higher levels of parental school involvement, higher special education engagement, and closer and more productive parent teacher relationships.


Eligibility criteria:
inclusion criteria: parents of children who participated in our screening and assessment study, whose children received diagnoses of autism through our assessment, and * whose children are turning 3 and transitioning out of early intervention services. exclusion criteria: children who are medically complex or * have a previous diagnosis of asd outside of our study or * don't have a parent/guardian who speak/understand sufficient english or spanish to complete study materials or * don't qualify for early intervention services
intraoperative imagery of breast cancer with folate-fitc (ec17)

Conditions: Resectable Breast Cancer

Summary: breast cancer is the most common cancer and the second cause of cancer mortality in women. there are approximately 200,000 new cases of breast cancer a year. classically, breast cancers are divided into two groups, invasive and non-invasive. a mainstay of the treatment of both of these types is surgical resection not only for therapeutic purposes but also for diagnostic purposes. breast conserving therapy includes surgical lumpectomy and post-operative radiation. however, despite best surgical practices, when patients undergo bct anywhere from 20 - 40% of these patients have margins positive for cancer. this leads to increased rates of reoperation which are quoted to be as high as 30% and increased local recurrences. there is an over expression of folate receptors located on the surface of many human carcinoma nodules.specifically for breast cancer up to 33% of all breast cancers over express the folate receptor. folate-fluorescein isothiocyanate, or folate-fitc, also identified as ec-17, targets folate receptors over expressed in certain cancers such as breast cancer, and could help in better identifying the margins of the cancer thereby achieving negative margins.


Eligibility criteria:
inclusion criteria: 1. adult patients 18 years of age and older 2. patients presenting with breast cancer presumed to be resectable by lumpectomy and/or mastectomy on pre-operative assessment 3. good operative candidate 4. subject capable of giving informed consent and participating in the process of consent. exclusion criteria: 1. pregnant women as determined by urinary or serum beta hcg within 72 hours of surgery 2. patients with a history of anaphylactic reactions to folate-fitc or insects 3. at-risk patient populations 1. "people who would be easily lost to follow up (ex: people who are homeless or alcohol dependent) 2. patients unable to participate in the consent process (children and neonates).

Keywords: breast cancer
thymosin α1 use in rheumatic heart disease patients undergoing cardiac surgery on cardiopulmonary bypass

Conditions: Rheumatic Heart Disease; Cardiopulmonary Bypass; Immunotherapy

Summary: rheumatic heart disease usually accompanied by weakened immune function. and the cardiopulmonary bypass further aggravating the decline of immune function. therefore, the prevention of postoperative immune function collapse is of great clinical value, and immunomodulatory therapy with thymosin alpha 1 may be beneficial. this study was designed to test the hypothesis that the administration of thymosin alpha 1 will improve the immune function and prognosis of patients.


Eligibility criteria:
inclusion criteria: * the patients are conformed to 2004 who guidelines for rheumatic fever and rheumatic heart disease; * patients planning to undergo cardiac surgery were enrolled. * the patients' age between 18 \~80 years old. * agree to participate in the study and sign the informed consent. exclusion criteria: * patients allergic to thymosin α1; * lactating women and pregnant women; * patients with mental diseases, drug and alcohol dependence; * refuse to participate in this study and refuse to sign the informed consent
reducing unsafe alcohol use in hiv-positive individuals

Conditions: Alcohol Abuse

Summary: the main aim of this study is to test an intervention to reduce unsafe drinking among hiv-positive primary care patients. the intervention consists of a brief motivational interview, which is combined with daily alcohol monitoring through the use of an interactive voice response system ivr (automated telephone system). subjects who receive the enhanced motivational interview are expected to show greater improvements in drinking than individuals who receive the standard motivational interview or view a dvd on hiv self-care.

hiv infection is a widespread health problem in the u.s. antiretroviral treatment has increased longevity and changed the nature of risk factors for morbidity and mortality. alcohol consumption has become an increasingly serious health issue among hiv primary care patients. drinking is a key factor in progression to severe liver damage (especially those co-infected with hepatitis), and liver disease is now one of the most common causes of death among those with hiv. excess drinking is also associated with medication noncompliance, reduces the effect of antiretroviral treatment, and is linked to other health problems. therefore, helping hiv patients reduce unsafe drinking is crucial to their long-term health. the intervention combines the brief mi, an established, evidence-based counseling approach, with an innovative procedure designed to strengthen the effects of the mi. an effective, easily implemented alcohol-reduction intervention could be incorporated into standard care in hiv clinics helping prevent or slow the progress of some medical problems in hiv-infected individuals, improve medication compliance, prolong lifespan and decrease risk behavior associated with alcohol use. comparison(s): enhanced brief motivational interview (including an ivr component for alcohol self-monitoring purposes), brief motivational interview, viewing a dvd on hiv self-care.

Eligibility criteria:
inclusion criteria: * male and females 18 years of age or older. * participants have had 4 or more drinks on any day in the prior 30 days assessed via standardized questions. * participants are referred to a study mi counselor by clinic staff as needing an intervention for drinking * participants agree to random assignment and provide informed consent exclusion criteria: * participants who are currently psychotic, suicidal or homicidal. * participants who have definite plans to leave the greater new york metropolitan area within the study period. * participants who demonstrate gross cognitive impairment as evidenced on the halstead-reitain trails (a). * participants who do not speak english or spanish, or have hearing impairments that preclude use of the telephone.

Keywords: unsafe drinking human immunodeficiency virus motivational interviewing
effects of ttpb vs pifb on opioid consumption in patients after cardiac surgery.

Conditions: Pain; Postoperative

Summary: the objective of this study is to compare the effects of ttpb vs pifb on postoperative opioid consumption in patients undergoing open cardiac surgery.

cardiac surgery performed through median sternotomy is associated with significant postoperative pain.poststernotomy pain leads to decreased patient satisfaction, delirium, cardiovascular complications (hypertension, tachycardia, arrhythmias), hyperglycemia and respiratory complications (bronchial secretion stasis, atelectasis and pneumonia).high-dose opioids can provide good postoperative analgesia for patients undergoing heart surgery. however, opioids have some side effects.the advent of ultrasound-guided regional anaesthesia led to the development of fascial plane chest wall block as transthoracic plane block and pectointercostal fascial block.

Eligibility criteria:
inclusion criteria: 1. age between 18 and 75 years. 2. patient scheduled to undergo elective on-pump cardiac surgery with sternotomy. 3. american society of anesthesiologists classification of physical status \< iv. exclusion criteria: 1. emergency surgery. 2. off-pump surgery. 3. redo surgery. 4. ejection fraction less than 35%. 5. refusal of the patient. 6. known hypersensitivity to la. 7. chronic opioid use or chronic pain patient. 8. psychiatric problems or communication difficulties. 9. liver insufficiency (defined as a serum bilirubin ≥ 34 μmol/l, albumin ≤ 35 g/dl, inr ≥ 1.7) 10. renal insufficiency (defined as a glomerular filtration rate \< 44 ml/min). 11. obstructive sleep apnea syndrome. 12. coexisting hematologic disorders. 13. pregnancy or breastfeeding.

Keywords: ttpb pifb
which exercises should diabetic patients do?

Conditions: Type2 Diabetes; Physical Activity

Summary: type 2 diabetes mellitus (dm) is a widespread worldwide disease. exercise therapy is an effective method but which exercise types are more effective is an important question. this study was designed to compare the effects of three different exercise programs on physical function and quality of life in type 2 dm. forty-two patients with type 2 dm participated in the study. the patients were randomly assigned to three groups. client based exercises in accordance with physiotherapy assessment were applied to group 1 (aged 51.42±4.60 years; body mass index 35.28±4.21 kg/m² kg/m²), clinical plates exercises were applied to group 2 (aged 53.07 ±5.12 years; body mass index 35.56±4.83 kg/m²) and a standard program including calisthenics exercises were applied to group 3 for 12 weeks, 3 days a week. 6 minutes walk test (6 mwt) and physiological cost index (pci), timed up and go test (tug) and sf-36 quality of life questionnaire were performed before and after the 12-week exercise program.


Eligibility criteria:
inclusion criteria: * patients who can walk independently. * patients who accept doing exercises for 12 weeks, 3 days a week properly patients whose cognitive status are enough for understanding and realizing different exercise types. exclusion criteria: * patients with orthopaedic or surgical problems that prevent walking. * patients with neuropathy that prevent walking. * patients who have foot ulcers. * patients with neurological problems. * patients with cardiac, pulmonary and systematic problems that cause contraindication for exercise.

Keywords: type 2 diabetes mellitus exercise physical performance physiological cost index
efficacy of doll therapy in the dementia in acute geriatric inpatients

Conditions: Dementia

Summary: summary. behavioral and psychological symptoms of dementia (bpsd) represents a huge emotional stress and an important burden for the patients and the caregivers severely reducing their quality of life. bpsd worsen during hospitalization and require the administration of psychotropic drugs that are often insufficient to control the symptoms, and may cause severe adverse events. the investigators propose the use of empathy dolls in order to reduce bpsd and in particular agitation and aggressiveness in acute geriatric in-patients affected by moderate to severe forms of dementia. the use of doll therapy in the clinical routine will allow to reduce the use of psychotropic drugs, shorten hospitalization, reduce professional and family caregiver burden improving patients' and families' quality of life.


Eligibility criteria:
inclusion criteria: * age ≥65 years * diagnosis of dementia moderate to severe clinical dementia rating scale (cdr) ≥2 * presence of agitation and/or aggressiveness * manual and visual abilities sufficient in order to interact with the doll. exclusion criteria: * age \<65 years; * refuse to participate; * mild forms of dementia (cdr\<2); * contraindication for dt as experience of mournful or traumatic events related to parental experience; * life expectancy lower than 3 months; * infectious diseases requiring isolation; * negative interaction with the doll, * presence of delirium.