Kornimate/medical-research-clean huggingface dataset:
intervention with omega-3 in children with attention deficit hyperactivity disorder(adhd)

Conditions: ADHD; ADD

Summary: this study aims to determine if marine monounsaturated and polyunsaturated fatty acids can benefit children aged 6-16 years with adhd and related symptoms. it is a randomized, double-blind, placebo-controlled study involving approximately 330 children from norway. the study will assess adhd symptoms reported by caregivers, teachers, and the child at baseline, after 6 months of treatment, and 6 months post-treatment. secondary outcomes will include reading and writing difficulties, cognitive functions, and physical health.

children with adhd often exhibit low blood levels of omega-3 fatty acids, which are not correlated with their diet. low omega-3 levels are associated with poor cognition and behavior. previous research indicates that omega-3 supplements can enhance literacy, behavior, memory, and reaction time in children with adhd, although the improvements are generally small to modest. a study on adolescent mental health in north norway from 2003-2005 revealed that adolescents consuming more fish had lower levels of hyperactivity compared to those with lower fish consumption (unpublished results from the norwegian arctic adolescent health study, siv kvernmo). key limitations in existing studies include small sample sizes, varying methodologies, short intervention periods, and the absence of control groups. this study addresses these limitations by using whole marine oil from the zooplankton calanus finmarchicus, which naturally contains stearidonic acid (a precursor to epa) and astaxanthin, a natural antioxidant. previous clinical studies did not utilize pure oil from zooplankton such as calanus finmarchicus. this oil is not chemically processed, retaining its natural antioxidants. blood tests will be conducted before and after the 6-month intervention period to measure the omega-3 index and include general hematology and biochemistry.

Eligibility criteria:
inclusion criteria: - adhd according to dsm-iv criteria exclusion criteria: * iq below 70 * infantil autism, psychosis, bipolar disorders and serious somatic disease * any abnormal or pathological blood test during trial * adhd medication

Keywords: adhd omega 3 children nutrition mufa add pufa calanus learning difficulties
effects of probiotics and electrophysiologic therapy on endometrium repair

Conditions: Uterine Endometrial Repair

Summary: this study aimed to investigate the effects of probiotics in combination with pelvic floor muscle electrophysiologic therapy on the uterine endometrial repair and reproductive prognosis in patients after surgery for intrauterine adhesion

post-traumatic repair disorder of endometrium can cause intrauterine adhesions, amenorrhea and infertility, which seriously endanger women's reproductive health. in our previous study, high throughput sequencing of intrauterine microorganisms showed that the content of lactic acid bacteria in the uterine cavity of patients with intrauterine adhesions was significantly lower than that of normal people. concurrently, our previous studies found that chronic endometritis can aggravate endometrial fibrosis, then affect the repair of endometrial trauma, and increase the recurrence of intrauterine adhesion. our previous study also suggest that stem cells are beneficial to the repair of endometrium. studies have shown that lactic acid can inhibit inflammatory response and regulate the proliferation of intestinal stem cells. so can lactic acid also change the microbial environment in uterine cavity to inhibit endometrial inflammation and regulate the proliferation of endometrial stem cells to help repair endometrial wounds? in addition, electrical stimulation can relieve depression and anxiety and play a sedative effect. in recent years, some studies have shown that pelvic floor electrophysiological therapy can improve the intimal blood flow resistance index of thin endometrium. therefore, whether or not the pelvic floor electrophysiological therapy can repair the endometrium after the intrauterine adhesion. we expect probiotics and electrophysiologic therapy can promote endometrial repair after electrosurgical resection of intrauterine adhesions.

Eligibility criteria:
inclusion criteria: (1) preoper- ative afs score was ≥9; (2) the prior menstrual cycle was regular, and the sex hormone was normal; (3) patients had fertility requirement; (4) male semen examination appeared normal; (5) there were no severe systemic diseases and no contradictions to aspirin, estrogen, and surgery exclusion criteria: (1) preoperative afs score was \<9; (2) prior menstrual cycle was irregular and sex hormone was abnormal, or patients had endocrine factors that caused amenorrhea, menstrual reduction, and infertility; (3) patients had no fertility requirement; (4) patients had male factor infertility; (5) patients had contradictions to estrogen and aspirin such as cancers (breast cancer and endometrial cancer), thrombotic diseases, allergy to antipyretic anal- gesics, severe liver injury, hypoprothrombinemia, vitamin k deficiency, hemophilia, thrombocytopenia, and gastric or duodenal ulcer and asthma

Keywords: probiotic electrophysiologic therapy uterine endometrial repair intrauterine adhesion
atrial fibrillation cycle length measured on transesophageal echocardiography

Conditions: Atrial Fibrillation

Summary: background: the atrial fibrillation cycle length (afcl) measured by electrophysiologic study is well known parameter for the maintenance of sinus rhythm after dc cardioversion (dccv) or ablation therapy. the aim of this study was to test whether a afcl measured by transesophageal echocardiography (afcltee) could predict the outcome after dccv. methods: in 100 consecutive patients with non-valvular af, tee will be performed within 6 hours before dccv. the afcltee was measured by averaging 10 sequential peak to peak intervals of atrial fibrillary waves seen in the pulsed wave doppler image on the left atrial appendage. the primary endpoint was af free survival rate at 6 months after dccv.


Eligibility criteria:
inclusion criteria: * atrial fibrillation exclusion criteria: * moderate or severe mitral stenosis * prosthetic heart valve
analysis of data collected in the european group for blood and marrow transplantation (ebmt) registry on a cohort of patients receiving plerixafor

Conditions: Lymphoma; Multiple Myeloma

Summary: in the european union (eu), plerixafor is indicated in combination with granulocyte colony stimulating factor (g-csf) to enhance mobilisation of haematopoietic stem cells (hscs) to the peripheral blood (pb) for collection and subsequent autologous transplantation in patients with lymphoma and multiple myeloma (mm) whose cells mobilise poorly. this is a clinical outcome analysis of a prospectively defined cohort of patients with data reported retrospectively to the european group for blood and marrow transplantation (ebmt) who have lymphoma or multiple myeloma (mm), whose cells mobilize poorly, and who have undergone autologous haematopoietic stem cell (hsc) transplantation during the years 2008 up to and including 2012. the ebmt is a non-profit, scientific society representing more than 600 transplant centers mainly in europe. the ebmt promotes all activity aiming to improve stem cell transplantation or cellular therapy, which includes registering all the activity relating to stem cell transplants. data are entered, managed, and maintained in a central database with internet access; each ebmt center is represented in this database. the analysis of data from a well established registry like the ebmt registry allows for follow up of a large number of patients who are representative of the patient population receiving plerixafor.


Eligibility criteria:
inclusion criteria: for inclusion in the cohort analysis, patients must have data in the ebmt registry that meet the following criteria: * adults diagnosed with lymphoma or multiple myeloma (mm) * received first autologous transplants of peripheral blood (pb) non ex-vivo manipulated stem cells in the time period listed above using cells mobilised with one of the following regimens: * plerixafor plus granulocyte colony stimulating factor (g-csf) * plerixafor plus g-csf plus chemotherapy * g-csf alone or * g-csf plus chemotherapy note: patients included in the plerixafor groups will be those treated according to the label * provision of informed consent (i.e., all patients with data in the ebmt registry will have signed consent at the time of transplantation for the potential use of their data for analysis) exclusion criteria: * patients treated with plerixafor not according to the european union (eu) label. * patients whose graft product underwent ex vivo manipulation will be excluded from analysis
imr evaluation in patients with coronary sinus reducer implantation (inroad study)

Conditions: Refractory Angina Pectoris

Summary: the inroad is an investigator-driven, prospective, study in which patients undergoing coronary sinus reducer implantation (reducer) for chronic refractory angina undergo evaluation of the index of microcirculatory resistance (imr) at the time of implantation, and at 4 months follow-up

refractory angina (ra) is a chronic condition (present for at least 3 months) of moderate-severe symptoms (canadian class cardiovascular society \[ccs\] ii-iv) due to coronary artery disease which cannot be adequately controlled by the combination of optimal medical therapy and coronary revascularization. the clinical impact in terms of quality of life, re-hospitalization and socio-health costs is extremely negative. in this context, the therapeutic goals are primarily the management of the symptom and improvement the patient's quality of life. the unpaid therapeutic demand of these patients has brought out a large number of medical and interventional treatments, including the coronary sinus reduction system (reducer). numerous clinical studies and registries have been carried out and they proved both the efficacy and safety in the use of reducer. the physiological mechanism that are supposed to be behind the antianginal effect of coronary sinus intervention are essentially two: 1. redistribution of coronary flow from the subepicardium to the subendocardium. 2. coronary neoangiogenesis in both cases, the primum movens of the reducer's therapeutic mechanism is attributable to the increase in venous pressure due to narrowing of the coronary sinus. nevertheless, this mechanism of action is theoretical and has never been objectively tested. the evaluation of microcirculatory resistance by imr before and after reducer implantation could be the most effective way to confirm this hypothesis.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * chronic refractory angina refractory to medical and interventional therapies. * at least one open coronary artery (excluded right coronary artery) where to performs imr evaluation * ability to provide informed written consent * life expectancy ≥1 year exclusion criteria: * recent (within 3 months) acute coronary syndrome * left ventricular ejection fraction of \<30% * severe valvular heart disease * inability to perform imr * technical contraindications to the implant ( a pacemaker electrode in the coronary sinus, mean right atrial pressure \>15mmhg, anomalous coronary sinus anatomy)

Keywords: angina microcirculation resistance coronary sinus reducer
optimal duration of antiplatelet therapy after bioresorbable vascular scaffold implantation to reduce late coronary arterial thrombotic events

Conditions: Percutaneous Transluminal Coronary Angioplasty; Coronary Disease

Summary: the purpose of this study is to evaluate optimal duration of antiplatelet therapy after bioresorbable vascular scaffold implantation to reduce late coronary arterial thrombotic events.


Eligibility criteria:
inclusion criteria: 1. men or women at least 19 years of age 2. patients undergoing dual- or triple-antiplatelet therapy at least 12-14 months after pci with bvs 3. among the participants underwent pci with bvs, event-free patients who survived the first 12 months without death, serious mi, stroke, repeat revascularization or major bleeding (except non-significant peri-procedural mi) 4. the patient or guardian agrees to the study protocol and the schedule of clinical follow-up, and provides informed, written consent, as approved by the appropriate institutional review board/ethical committee of the respective clinical site. exclusion criteria: 1. contraindication to antiplatelet therapy 2. if the physician believes that the patient need continuation of dual anti-platelet therapy because of comorbidities (acs, peripheral vascular disease, significant carotid disease, etc.) 3. continuous administration of clopidogrel is impossible due to comorbidities of the patient (major bleeding history, bleeding diathesis) 4. cardiac co-morbid conditions are present with life expectancy \<1 year or that may result in protocol non-compliance (per site investigator's medical judgment). 5. pregnancy test positive (hcg test is performed before randomization in all fertile women)

Keywords: dapt bvs bioresorbable vascular scaffold dual antiplatelet therapy
biomechanical evaluation of wrist ligament injuries: diagnostic tool to detect wrist instability

Conditions: Scapholunate Interosseous Ligament; Torn Wrist Ligaments

Summary: damage to the ligaments of the wrist occurs frequently, however, it is not well publicized or understood. our previous and current biomechanical studies have shown that damage to certain wrist ligaments is the likely cause of wrist instability and pain. based on our three dimensional models and animations of actual cadaver motions with various ligaments intact or sectioned, we have identified several changes in how the carpal bones move and are positioned relative to the radius with various levels of instability. using this information, we have developed a mathematical model that can predict in cadaver wrists which groups of ligaments have been injured. we started, under irb approval, a prospective clinical study to evaluate the reliability of this mathematical model. during the past 5 years we have studied 13 patients with suspected wrist ligament injuries who were previously scheduled for surgical treatment. ct scans have been performed of the injured wrist and for comparison purposes, the contralateral, uninjured wrist. during these 5 years, there were no problems with the conduct of the study. during these 5 years the only changes to the original study application were * a) to include a ct scan of the contralateral wrist for comparison purposes * b) a paper handout given to potential subjects * c) to add additional people to the study team. the principal investigator, blinded to the results of the ct scan, surgically explores and treats these patients in the same manner that he would for any patient with suspected wrist ligament injuries. during the surgery, the investigator determines the integrity of the various wrist ligaments. the prediction of which ligaments are damaged, based upon the ct scan information and mathematical model is compared to the actual surgical findings. the importance of this study is to develop a tool that will allow one to rapidly and non invasively diagnose wrist instability and initiate treatment before further damage is done.


Eligibility criteria:
inclusion criteria: * patients who have suffered ligamentous injuries to their wrists and have been referred to the principal investigator * subject selected to undergo surgery * the ethnicity and racial makeup of the group is similar to the demographics of the surrounding referral base * there will be no exclusion of any gender, racial or ethnic group exclusion criteria: * pregnant women will not be included because of increased anesthetic risks at surgery.

Keywords: scapholunate instability neural networks scaphoid lunate suspected torn scapholunate interosseous ligament suspected other torn wrist ligaments
comparison of post tooth extraction healing using different xenograft materials

Conditions: Alveolar Bone Loss

Summary: the purpose of this pilot study is to conduct a interventional prospective clinical trial to evaluate the efficacy of three different xenografts for ridge preservation by comparing the quality of newly formed bone using histomorphometric and micro ct analysis.the three xenograft materials under investigation are bio-oss® (bovine derived xenograft), equimatrix® (equine derived xenograft), and endobon® (bovine derived xenograft). there are no prospective studies comparing the effectiveness of these three materials, bio-oss®, endobon® and equimatrix®, when placed in extraction sockets. participants will be recruited from patients in the tusdm clinics that require extraction of single rooted non-molar tooth and are treatment planned to receive dental implants in the future. participants will be randomized to receive one of the three xenograft materials after tooth extraction. the percentage of newly formed bone and bone density will be compared between the three materials 4-6 months after ridge preservation.

this is a pilot prospective clinical trial in which histological and micro ct analysis will be utilized to compare between endobon®, equimatrix®, and bio-oss®. primary aim: compare the percentage of newly formed bone between equimatrix®, bio-oss® and endobon®. the investigators hypothesize that the mean percentage of newly formed bone from equimatrix® will be higher than bio-oss® and/or endobon®. secondary aim: compare the bone density between equimatrix®, bio-oss® and endobon®. the investigators hypothesize that the bone density from equimatrix® will be higher than bio-oss® and/or endobon®.

Eligibility criteria:
inclusion criteria: * non-restorable single rooted tooth in anterior or premolar region * patient previously treatment planned for implant procedure and implant restoration. * \> 10 mm from maxillary sinus or inferior alveolar canal (iac) * intact buccal bone (only minor dehiscence or fenestrations (approximately \< 50% of socket depth) can be accepted * non-smokers. * patients treatment planned for extraction and ridge preservation at tufts university school of dental medicine. exclusion criteria: * poor oral hygiene (plaque index\>30%). * systemic diseases that affect bone metabolism: i. osteoporosis ii. osteomalacia iii. hyperthyroidism iv. hyperparathyroidism v. paget's disease * inflammatory and autoimmune diseases of the oral cavity (severe bone loss) (self-report): i. severe chronic periodontitis ii. aggressive periodontitis iii. necrotizing ulcerative periodontitis iv. crohn's disease v. multiple sclerosis vi. rheumatoid arthritis vii. systemic lupus erythematosus * history of radiation to the head and neck, and /or chemotherapy. * current corticosteroid therapy. * history of iv bisphosphonates therapy or \>3 years of oral intake. * infectious diseases such as hiv, tuberculosis, hepatitis (self-report). * known allergy to research related materials. * self-reported pregnancy or lactation
diagnosis of pd and pd progression using dwi

Conditions: Parkinson's Disease

Summary: this project will evaluate the utility of diffusion tensor imaging (dti) as an adjunctive method to improve early diagnosis of parkinson's disease (pd). two populations will be evaluated in this study: 1) individuals with uncertain pd diagnosis who receive a datscan, and 2) individuals with well characterized pd and healthy controls, drawn from the fully enrolled parkinson's progression markers initiative (ppmi) pd and control cohorts.

specific aim 1a: compare the outcome of a dti based prediction with a contemporaneous clinical dat scan in 100 subjects with suspected parkinsonism, and determine rate of concordance between the two diagnostic techniques. specific aim 1b: compare predictive accuracy of a baseline dti with a "gold standard" expert diagnosis after 36 months of follow up in 100 subjects receiving datscan for suspected parkinsonism. specific aim 2a: use tbm to evaluate volume and cross-sectional caliber (based on point-wise fiber track direction) of the fimbria, pallidonigral tracts, and subthalamic-nigral tracts in pd and healthy controls. ascertain if changes in white matter volume and caliber can be used to predict presence of pd from the ppmi study. secondarily, using a model free approach, determine what white matter features based on tbm predict presence of disease. specific aim 2b: use tbm to determine if an increased rate of change in volume and cross-sectional caliber of the fimbria, and hypertrophic pallidonigral, and subthalamic-nigral tracts identified in aim 2a, are associated with a more rapid rate of disease progression in pd. secondarily, using a model free approach, determine what white matter features based on tbm predict a faster rate of disease progression over the 5 year course of the ppmi study. specific aim 3a: compare dti fa in td-pd and pigd-pd in the thalamus and lobule ix of the cerebellum , studying subjects from the ppmi study. predict signal in these regions will predict phenotypic expression of disease. using tbm and bootstrapping, determine the relationship between phenotypic expression of disease and white matter input/output pathways from the thalamus, and from lobule ix of the cerebellum.

Eligibility criteria:
inclusion criteria: * patients 19 and older * referred for clinical datscan for possible pd * controls from the ppmi dataset. exclusion criteria: * pregnant women * participants that cannot participate in mri (metallic artifact or other contraindication(s) to mri at 3t)
safety of epidural fentanyl and adrenalin during childbirth

Conditions: Pregnancy; Pain

Summary: investigation of pharmacokinetic effects of combining fentanyl and adrenalin in the epidural solution given to women in childbirth

healthy women with indication for labor epidural at the labor clinic, rikshospitalet university hospital, may be included. a randomized, placebocontrolled, double blind,comparison of epidural with and without adrenalin. outcome: length of birth, quality of pain relief, total amount of epidural solution injected, and plasma concentration of fentanyl.

Eligibility criteria:
inclusion criteria: * pregnant women at term in active labor exclusion criteria: * age below 18 years * bmi \> 40 * drug hypersensitivity

Keywords: labor analgesia fentanyl epinephrine
muscle relax affects outcomes of robotic surgery

Conditions: General Anesthesia; Postoperative Complications

Summary: during robotic laparoscopic surgery, a high intraperitoneal pressure may result in high airway pressure and inadequate perfusion of the abdominal organs, and as a result the postoperative outcomes. degree of neuromuscular blockade (nmb) can affect the intraperitoneal pressure. in this study, the patients undergoing robotic laparoscopic surgery will be assigned to deep nmb group and moderate nmb group. perioperative outcomes including maximal intraperitoneal pressure, maximal intraoptic pressure, quality of emergence, postoperative pain, and incidence of postoperative respiratory complication will be compared. the results of this study will provide evidence for optimizing nmb protocol of robotic laparoscopic surgery.


Eligibility criteria:
inclusion criteria: * patients scheduled for elective robotic laparoscopic surgery under general anesthesia * american society of anesthesiologists status 1-2 * body mass index of 18-30kg/m2 * patients scheduled to be positioned in trendelenburg position during surgery exclusion criteria: * patients allergic to rocuronium * patients with neuromuscular dysfunction * patients with existed pulmonary diseases * patients with hepatic or renal dysfunction

Keywords: robotic surgery laparoscopic surgery neuromuscular blockade postoperative complication