Kornimate/medical-research-clean huggingface dataset:
platelet-rich fibrin(prf) membrane in ophthalmic diseases

Conditions: Platelet-rich Fibrin; Macular Holes; Pterygium; Glaucoma

Summary: the goal of this clinical trial is to observe the role of prf in treating ophthalmic diseases.the efficacy and safety of prf were validated for four ophthalmic conditions: macular hole, pterygium, corneal ulcer, and patients undergoing trabeculectomy for glaucoma. the main question aims to answer is prf's effectiveness in ocular surface and fundus diseases. participants will be divided into 2 groups, the experimental group will be treated with prf and the control group will be treated with conventional surgery, with a 12-month postoperative follow-up to determine the role of prf on wound healing in ophthalmic diseases.

patients suffering from pterygium, macular hole, corneal ulcer, and glaucoma requiring for trabeculectomy , who visited renmin hospital of whuhan university, were chosen to participate in this study. the participants were randomly divided into the experimental group (prf group) and the control group (conventional group). the prf group received prf membrane treatment, while the conventional group received conventional surgical treatment. before and after surgery, participants underwent a comprehensive ophthalmological exam at 1 week, 1 month, 3 months, 6 months, and 12 months. the outcome indicators are monitored and can vary depending on the disease. participants with pterygium were examined for graft dissolution and complications. participants with macular hole were monitored for hole closure, visual acuity recovery, and retinal blood flow recovery. participants with corneal ulcer were monitored for lesion healing and complications such as degree of corneal vascularization and opacity. participants with glaucoma were monitored for postoperative intraocular pressure (iop), degree of conjunctival leakage in the filtration zone, and degree of scarring in the filtration zone.

Eligibility criteria:
inclusion criteria: 1. diagnosis of macular hole confirmed by fundus examination; 2. diagnosis of pterygium by slit lamp; 3. patients requiring trabeculectomy for glaucoma; 4. diagnosis of corneal ulcer confirmed by slit lamp. exclusion criteria: 1. combination of other active ophthalmic diseases, such as acute conjunctivitis and uveitis; 2. previous history of ophthalmic trauma and ophthalmic surgery; 3. recent use of anticoagulant or antiplatelet drugs; 4. combination of serious systemic diseases such as hypertension and diabetes mellitus.

Keywords: prf; pterygium; macular hole; corneal ulcer
patient satisfaction and visual outcomes after bilateral panoptix implantation in patients with previous multifocal contact lens

Conditions: Cataract

Summary: to evaluate spectacle independence and patient satisfaction and visual outcomes after bilateral panoptix implantation in patients with previous multifocal contact lens experience.

this study is a single-arm unmasked clinical evaluation study of patient satisfaction after successful bilateral cataract surgery. subjects will be assessed pre-operatively, operatively and at 1 day, 1 week and 3 months post-operatively. clinical evaluations will include administration of a visual disturbance questionnaire (quvid), and a satisfaction questionnaire (iolsat), as well as measurement of bilateral visual acuity and manifest refraction.

Eligibility criteria:
inclusion criteria: subjects are eligible for the study if they meet the following criteria: note: ocular criteria must be met in both eyes. * adult cataract patients undergoing uncomplicated cataract surgery with clareon panoptix iol implantation (non-toric/toric). * visually significant cataracts bilaterally. * history of successful soft multifocal contact lens use in the past (within ≤ last 5 years). * healthy ocular exam. * gender: males and females. * willing and able to provide written informed consent for participation in the study. * willing and able to comply with scheduled visits and other study procedures. exclusion criteria: if any of the following exclusion criteria are applicable to the subject or either eye, the subject should not be enrolled in the study. * previous monovision patients. * ocular comorbidity that might hamper post operative visual acuity (uveitis, keratoconus, retinopathies, glaucoma). * previous ocular or refractive surgery. * expected monocular post-op distance va worse than 20/25 (snellen) in either eye. * refractive lens exchange. * angle kappa measurement in a single eye over 0.6 mm. * irregular corneal astigmatism or ectasia. * difficulties comprehending written or spoken english language. * patients with physical or intellectual disability (e.g. down's syndrome, parkinson's disease; unable to fixate). * severe/uncontrolled ocular surface disease/dry eye disease. * intraoperative complications during procedure. * visual expectations exceed outcomes. * strabismus (with or without amblyopia). the principal investigator reserves the right to declare a patient ineligible or non-evaluable based on medical evidence that indicates they are unsuitable for the trial. pregnancy has a known effect on the stability of refractions and visual acuity. as such, subjects who become pregnant during the study will not be discontinued but their data may be excluded from analyses of effectiveness.
comparative effectiveness of emergency ultrasound guided management of pediatric soft tissue infections

Conditions: Soft Tissue Infection

Summary: to examine the effect of point-of-care ultrasound (pocus) management guidance on pediatric skin and soft tissue infections treatment failure rate, as well as emergency department process outcome.


Eligibility criteria:
inclusion criteria: * history and examination findings consistent with possible abscess or cellulitis per the treating clinician. * minimal lesion diameter for inclusion is 1cm. exclusion criteria: * suspected soft tissue infections involving or near mucosal membranes (e.g. perirectal, peritonsillar, vulvovaginal areas) * facial lesions * paronychia or felon * parent or patient refusal of consent * unsuitable subjects deemed by treating clinicians.

Keywords: pediatric soft tissue infections ultrasonography effectiveness
translating neuroscience to population health

Conditions: Overweight and Obesity

Summary: the current study will examine the relationship between brain responses and a guided imagery exercise in overweight and obese individuals. results of this work are highly relevant to public health because they employ neuroimaging methods to understand food decision-making. findings from this study will inform health decision making and holds great potential for future translation across multiple health behaviors and scalable interventions to impact population health

negative health behaviors (e.g. overeating, smoking) are associated with increased negative health outcomes. engaging in healthy behaviors is not always rewarding (e.g. carrot vs. cake). neural models of healthy behaviors focus on the balance between reward and regulation brain regions. the current pilot application examines the engagement of these regions during the evaluation of food and nonfood cues before and after a guided imagery exercise targeting positive associations with food and regulation. the long-term goal is to understand the interaction between positive associations with healthy foods and thinking about future rewards may influence healthy decision-making. the objective of the current study is to empirically test the combined effects of positive affect and positive episodic future thinking on brain activation.

Eligibility criteria:
inclusion criteria: * body mass index 25 to 55 kg/m2 * right-handed * not currently dieting or attempting to lose weight. exclusion criteria: * serious medical illness unsuitable for the magnetic resonance imaging scanner based on best clinical judgment * any neurologic or current psychiatric diagnosis * currently taking anti-seizure medication * history of concussion * left-handedness * risk for hazard due to magnetic fields such as metal in the body surgically or accidentally * pregnancy
altered faecal protease activity in irritable bowel syndrome patients in china

Conditions: Irritable Bowel Syndrome

Summary: irritable bowel syndrome (ibs) is a functional gastrointestinal disorder haracterised by abdominal pain or discomfort associated with altered bowel habits,while the mechanism is still not understood.recent advances have conceptualized the faecal supernatants of diarrhoea-predominant ibs have a substantially higher serine protease activity, while in china,almost no studies have reported about protease activity in ibs.


Eligibility criteria:
inclusion criteria: * patients fulfilling the rome iii criteria for ibs participated in the study - exclusion criteria: * organic gastrointestinal disorders were excluded by detailed blood and stool analyses, serological assays and colonoscopy.

Keywords: irritable bowel syndrome,protease activity,china
a clinical trial for hospitalized patients with covid-19 in ceará: rescovid study

Conditions: COVID-19

Summary: this is a case series of patients with covid-19 admitted to the northeast brazil region, in a referenced hospital for covid-19, during the 2020 covid-19 pandemic. data will be collected prospectively and retrospectively. the main objective is to describe the characteristics of critically ill patients with covid-19 and their clinical outcomes, and to identify risk factors associated with survival, to guide the strategy to mitigate the epidemic, both within each hospital and icu and in public health management.

the world's population has been recently dealing with a new infectious disease, sars-cov-2 epidemic, which was first reported in december 2019 in wuhan, china. the virus transmission was rapidly spread around the globe and the world health organization declared it as a public health emergency and it has been reported that sars-cov-2 is related to high morbidity and mortality rates. the total number of infected patients has risen fastly and at the end of february 2020, the first case in brazil was confirmed, suggesting that the sars-cov-2 is a pandemic situation. the clinical aspect of sars-cov-2 ranges from pneumonia to critically ill cases, including clinical treatment, mechanical ventilation, and sars. the acute respiratory failure of critically ill patients with covid-19 has different aspects, including hypoxemia of difficult treatment, associated in some cases with clotting disorders, changes in immunity and inflammatory phenomena that pose challenges for the management of these patients, whose mortality can be higher than expected. the public health school in fortaleza, ceara, brazil, implemented an action plan that provides several actions against covid-19, including a specialized hospital and crew to treat these patients. knowing the characteristics of critically ill patients with covid-19 and their clinical outcomes is extremely important to inform clinical decision-making and to guide the strategy to mitigate the epidemic, both within each hospital and icu and in public health management.

Eligibility criteria:
inclusion criteria: * confirmed covid-19 exclusion criteria: * n/a

Keywords: covid-19 hospitalization public health
a pilot study exploring efficacy and safety of amlodipine in the stented angina patients

Conditions: Coronary Artery Disease

Summary: 1. objectives primary objective to evaluate the difference of the peak oxygen uptake change (vo2 max, ml/kg/min) in amlodipine group against no ccb group at 9 months secondary objectives to evaluate the change of sublingual nitrate use per day against no ccb group at 1 and 3 months to evaluate the change of biomarkers against no ccb group at 9 months 2. subjects and centers 212, stable angina patients with angiographically confirmed significant residual stenosis 10, 3rd-grade, teaching hospitals in korea


Eligibility criteria:
inclusion criteria: * stable angina patient with angiographically confirmed significant residual stenosis * stenosis more than 50% in 2 major coronary arteries at least or stenosis more than 75% in 1 major coronary artery exclusion criteria: * no other pulmonary/psychiatry/musculoskeletal disorder limiting cpet * contraindicated to the cpet (e.g. unstable angina, aortic stenosis, uncontrolled hypertension, uncontrolled asthma, hypoxemia at rest, epilepsy, locomotor disorder, severe hypertension and febrile illness)
continous popliteal block for microvascular free flap reconstruction in ear, nose and throat surgery

Conditions: Head and Neck Cancer; Pain, Musculoskeletal

Summary: the aim of the study is to assess the effects of a continuous popliteal block on postoperative pain and recovery after major ear, nose and throat surgery with microvascular free flap reconstruction using a fibula graft.

tumors of the head and neck is one of the most common cancer types, and the incidence is increasing. management of these tumors is complex, and treatment can include surgery with extensive resection of the mandible or maxilla, which requires reconstruction using a microvascular free flap, oftentimes a part of the fibula. the injury to the operated leg can cause significant postoperative pain, which in these patients traditionally has been treated with intravenous opioids. these drugs have good analgesic properties, but also several side effects, such as fatigue, nausea and respiratory depression. the experience at skåne university hospital in lund has also been that the analgesic effect in the leg has been insufficient. the investigators would therefore like to evaluate the effect of adding a continuous popliteal block on postoperative pain and opioid consumption, as well as postoperative recovery. this type of block is regularly used for orthopedic surgery of the fibula, but its effects and significance have not been evaluated for the patient group in question. patients will receive information about the study and, if they opt to participate, be included during the routine preoperative visit. all patients included in the study will preoperatively receive a popliteal nerve block catheter in technical accordance with local procedure guidelines, and be randomized to either active substance (local anesthetic) or placebo (saline solution). they will receive a bolus injection of the allotted substance (blinded to both patient, care provider and investigator) at the start of surgery, followed by continuous infusion during the first, maximally, seven days. during this period pain, nausea and vomiting, as well as sensory and motor function in the operated leg will be recorded regularly. opioid consumption, need for other analgesics and ability to mobilize will also be noted. follow up of above mentioned parameters will be made at the first routine office visit at three months postoperatively.

Eligibility criteria:
inclusion criteria: * patients at skåne university hospital department of ear, nose and throat surgery undergoing major resection of maxilla or mandible and reconstruction using free fibula graft. * preoperatively able to walk (with or without aid). exclusion criteria: * neurological disease or peripheral neuropathy affecting the donor leg of the fibula graft. * conditions of coagulopathy, or treatment with anticoagulant drugs, that contraindicates peripheral nerve block according to local guidelines. * local anesthetic allergy. * inability to understand study information or answer questions.

Keywords: microsurgical free flaps popliteal nerve block head and neck cancer postoperative pain
effect of kettlebell training on musculoskeletal and cardiovascular health

Conditions: Musculoskeletal Disorders

Summary: neck/shoulder and back pain is quite common among employees in sedentary occupations. furthermore, many have a low level of fitness. strength training with dumbbells has been shown to alleviate neck/shoulder pain, but many people prefer to also have alternative training options. empirically, kettlebell training works the neck/shoulder/back while at the same time training the cardiovascular system. this type of training has not previously been tested in a randomized controlled trial. the aim of this study is to test the effect of kettlebell training on musculoskeletal pain, fitness, and muscle strength.


Eligibility criteria:
inclusion criteria: * employed * office workers exclusion criteria: * trauma * life threatening diseases * pregnancy
outcome of single burr hole under local anaesthesia in the management of chronic subdural hematoma

Conditions: Chronic Subdural Hematoma

Summary: aim of the work: is to evaluate the prognosis of single burr hole under local anesthesia in management of csdh according to clinical picture, risk factors, and age.

patients and methods: we studied 67 consecutive patients with csdh operated by single burr hole craniostomy under local anaesthesia from mars, 2014 to february, 2015 in zagazig university hospitals according to the aetiology, clinical picture, risk factors, and complications.

Eligibility criteria:
inclusion criteria:chronic subdural hematoma above 19 years old - exclusion criteria:age below 19 years acute subduralhematoma uncoperative patients -
pathogen identification of bacterial pneumonia via dna detection

Conditions: Pneumonia

Summary: pneumonia is a common cause of morbidity and mortality. the diagnosis of pneumonia from the microbiology perspective has been challenging. recent reports suggest the utility of nuclear acid detection for rapid and accurate diagnoses of these pathogens and their antibiotic-resistant spectrum. extracted bacterial nucleic acid in sputum specimen will be identified by nuclear acid detection assay kit with microfluidic pumping chip and lamp methods

sputum specimens normally collected from the patients with pneumonia for routine microbiologic testing and extra specimens will be evaluated via nuclear acid assay developed in our laboratory. the assay will be directed at variety of both pathogens, including streptococcus pneumoniae, hemophilus influenzae, klebsiella pneumoniae, staphylococcus aureus, pseudomonas aeruginosa, acinetobacter, mycoplasma pneumonia, chlamydia pneumoniae and legionella pneumophila, and common antibiotic-resistant genes, such as esbls genes, meca, oprd. the ultimate goal is to have an available panel of highly accurate and rapid (same day) assay, which will be carried out in several hours for identification. the extracted pathogen nucleic acid in sputum specimen will be identified by nuclear acid detection assay with microfluidic pumping chip and lamp methods. the species of bacteria and their antibiotic-resistant gene to be detected are as listed above. as nucleic acid extracts will be archived, other pathogens can be investigated in the future if the correlated assay is developed. all results obtained by nuclear acid detection will be compared to results for conventional testing as listed above. sensitivity, specificity and predictive values will be calculated. in cases where discordant results occur, additional testing and or medical history review will be properly conducted.

Eligibility criteria:
inclusion criteria: * greater than 18 years of age. * cough present greater than one day * history of fever * x-ray evidence of pneumonia. exclusion criteria: * pneumonia caused by tb, fungi and virus

Keywords: pneumonia
different aspects and etiologies of gastointestinal bleeding in patients with systemic lupus erythematosus

Conditions: Systemic Lupus Erythematosus

Summary: the association between sle and development of of gastrointestinal bleeding

systemic lupus erythematosus (sle) is an autoimmune disease characterized by multisystem inflammation, variable clinical manifestations, and a variable clinical course. it affects multiple systems and can occasionally manifest as hematological disorders and gastrointestinal (gi) tract abnormalities(1). the complications of sle are diverse and severe, and may include lupus pneumonitis, lupus encephalopathy, intestinal pseudo-obstruction, gastrointestinal bleeding, and vasculitis (2) . the potential severity of sle-related gi manifestations is concerning, considering that more than 50% of sle patients develop gi symptoms at some point during the course of illness. the incidence and prevalence of gi involvement during the course of sle disease vary widely. this could be due to less attention being paid to gi manifestations than other organ symptoms, such as lupus nephritis. according to an autopsy study, 60-70% of sle patients had evidence of peritonitis, whereas only 10% showed clinical manifestations throughout their lives(3). any part of the gi tract and the hepatobiliary system can be involved from the mouth to the anus. the liver can also be affected by sle; abnormal liver function test results were obtained in 23%-79% of cases and hepatomegaly in 39%-40%. in terms of risk factors for gi involvement in sle, sle patients with raynaud's phenomenon, hypocomplementemia, and positive anti-neutrophil cytoplasmic antibody were at increased risk of developing gi complications(4). the main pathological mechanisms of gi involvement in sle involved mesenteric vasculitis, intestinal pseudo-obstruction and protein losing enteropathy(5). there is a wide variation of gi manifestations, including gastro-esophageal reflux, dysphagia, abdominal pain, constipation, diarrhea, faecal incontinence, intestinal pseudo-obstruction (ipo), perforations, and haemorrhage. when gi presents as the initial affected system of sle, there is likely to be a delay in the diagnosis(6). clinical presentations of gi lupus are non-specific and can be difficult to differentiate from infective, thrombotic, therapy-related and non-sle aetiologies(7).

Eligibility criteria:
inclusion criteria: - patient more than 18 years old classified as systemic lupus erythematosus both sex exclusion criteria: * patients with other clinical conditions that causes gastrointestinal bleeding as ulcerative colitis \& chrons
the role of oxytocin in the perception of faces

Conditions: Healthy

Summary: the main objective of this project is to study whether intranasal oxytocin (ot) affects how young adults perceive and attend to infant and adult faces. based on existing research the investigators predict that oxytocin will facilitate the allocation of attentional resources on infant faces (compared to adult faces). the investigators also predict that oxytocin will enhance the activity of reward neural-networks associated with the perception of infant faces. the behavioral effects of ot (visual attention and face recognition) will be measured with eye-tracking while participants look at photographs of adult and infant faces. neurological effects (the activity of emotion and reward networks) will be measured with functional magnetic resonance imaging (fmri) while participants look at infant faces on a computer screen.


Eligibility criteria:
inclusion criteria: * healthy volunteers * norma or corrected to norma vision * participants are non parents * able to provide written informed consent and to comply with all study procedures exclusion criteria: * dementia or severe cognitive disorders * endocrine disease or malignancy * nasal obstruction or upper-respiratory tract infection * current or previous psychiatric disorder * current or previous use of psychoactive drugs * alcoholism or substance abuse * history of seizures * neurological disorder * previous head trauma * hypertension * cardiovascular disease * claustrophobia * ferrous metal in any part of the body