Kornimate/medical-research-clean huggingface dataset:
balance, tmj, social adaptive assessment in individuals with autism spectrum disorder

Conditions: Autism Spectrum Disorder; Temporomandibular Joint Disorders; Postural; Defect

Summary: the aim of our study is to evaluate temporomandibular joint (tmj), cervical posture, balance, dual-task performance, and social adaptation skills in individuals with autism. the study will be conducted at bartın lider special education and rehabilitation center following the approval of the ethics committee. individuals determined by the sample size calculated through power analysis will be included in the study. first, the socio-demographic characteristics (age, height, body weight, body mass index, education level, exercise and smoking habits, etc.) of the participants who voluntarily join the study will be recorded. participants will be divided into two groups: individuals with typical motor development and those with autism spectrum disorder (asd), and the same assessment tools will be used for both groups. individuals with typical motor development will serve as the control group. the assessment tools include the timed up and go (tug) test, the 10-meter walk test, the vineland adaptive behavior scale, the posturescreen android-based posture assessment application, and the helkimo clinical dysfunction index for craniomandibular disorders. based on the evaluation results, the relationships between tmj, cervical posture, functional balance, dual-task performance, and social adaptation skills in individuals with autism will be analyzed and compared with those of individuals with typical motor development.

it has been stated in the literature that individuals with autism spectrum disorder have postural control deficiency, but there is no study examining the dual task skills of these individuals and the contribution of these skills to social life. it has been stated in the literature that bruxism can cause tmj in individuals with normal development, and there are studies related to tmj's cervical problems and balance. however, there are no studies explaining the relationship between teeth grinding and dental problems in individuals with asd, temporomandibular joint problems and cervical posture and balance. studies suggest that multi-faceted evaluations be made in individuals with asd. the aim of our study is to evaluate tmj dysfunction, cervical posture, functional balance, dual task and social adaptation skills in individuals with asd. in terms of these evaluations, our study has the feature of a pilot study in the literature.

Eligibility criteria:
inclusion criteria: * having a diagnosis of autism spectrum disorder (asd) confirmed by a physician. * currently enrolled in a special education and rehabilitation center. * no vision problems. * ability to understand and follow instructions. * no cognitive impairments. * no walking difficulties. exclusion criteria: * individuals with comorbid secondary health conditions. * individuals who have undergone surgery in the past six months.
the effectiveness of "multi-psychological empowerment" courses

Conditions: Cancer; Oncology; Psychological; Self Efficacy; Communication

Summary: in the first-year project of this study, oncology nurses have reported experiencing massive stress, insufficient communication ability, and the need for communication-related training. 70% of them had moderate or higher severity of workload, fatigue, and psychological distress (at the measure point) before being provided with basic remote psychological support course (brpsc). a month after brpsc, some oncology nurses have indicated/affirmed the benefits of undergoing the comprehensive psycho oncology education training courses. thus, the second- and third-year continuation projects are focused on the development and delivery of multi-psychological empowerment courses (mpec) for oncology nurses


Eligibility criteria:
intervention group * inclusion criteria: * over 20 years old (inclusive) * oncology nurses currently working in clinical practice * at least receiving one course related to oncology nurse training, such as chemotherapy for nursing staff or oncology advanced training courses. * exclusion criteria: * those who are unwilling or unable to participate in this course training for a full one- year period. control group oncology nurses who do not need to be recruited for the comparison group will be students who participated in the remote psychological support course of the first year project effective comparison groups.

Keywords: training course oncology nurse psychological support self-efficacy
1 versus 2 hours post meal glucose monitoring in gestational diabetes on treatment

Conditions: Gestational Diabetes; Treatment Adherence

Summary: a study to compare between 1 and 2 hours post meal blood glucose monitoring in patients with gestational diabetes mellitus requiring treatment.

this study involves all pregnant women who attended our antenatal clinic with gestational diabetes mellitus requiring treatment. they will be randomised to either 1 or 2 hours post meal self blood glucose monitoring. the blood sugar profile is a staggered 7 points. they are followed up in the research clinic until delivery.

Eligibility criteria:
inclusion criteria: * gestational diabetes diagnosed based on national institute for health and care excellence guideline * requiring treatment either with metformin alone or combined with insulin exclusion criteria: * type 1 and 2 diabetes * bad obstetrics history * underlying medical disorders such as systemic lupus erythematosus * fetal anomaly * delivery elsewhere

Keywords: gestational diabetes treatment glucose monitoring
use of online personalized health record system to promote self-management of diabetes

Conditions: Diabetes Mellitus

Summary: diabetes is a major, growing, and costly chronic disease in the u.s., and implementation of recommended diabetes care remains poor, not merely suboptimal, and varied for a sizable proportion of americans with diabetes. to further reduce the treatment and adherence gaps in diabetes care, the researchers propose to evaluate a customized, continuous care management (cccm) program that actively supports a partnership between the patient and his/her multidisciplinary care management (cm) team using an online disease management (odm) system, which is integrated with a comprehensive electronic health record (ehr) system that includes a personal health record and secure patient-clinician messaging capabilities. the cccm program builds upon cm strategies proven effective in past studies and creates an odm system that is built upon and fully integrated with a leading, commercially available ehr product - providing a blueprint for instituting customized, continuous care management for many different chronic conditions in a range of ambulatory care settings.


Eligibility criteria:
inclusion criteria: * \>= 18 years of age * have a designated palo alto medical foundation primary care provider (pcp) * seen in primary or specialty care at the palo alto division at least once in the preceding 24 months * diagnosis of diabetes * baseline a1c \>= 7.5% exclusion criteria: * initial diagnosis of diabetes within the last 12 months * diagnosis of type 1 diabetes * inability to speak and read in english * lack of regular access to a computer with internet and email capabilities * unwilling to perform any self-monitoring at home, including blood glucose and blood pressure% * pregnant, planning to become pregnant, or lactating * currently enrolled in a care management program at palo alto medical foundation or elsewhere * pcp determination that the study is inappropriate or unsafe for the patient * investigator discretion for clinical safety or protocol adherence reasons

Keywords: diabetes blood glucose self-monitoring home blood glucose monitoring internet personal health record (phr) health information technology (hit) care management disease management diabetes self-management consumer health information medical records systems, computerized computerized medical records system automated medical records system electronic health record (ehr) remote patient monitoring
narrow qrs hf patients assessed by ecg belt

Conditions: Heart Failure; Cardiac Resynchronization Therapy

Summary: the purpose of this study is to quantitate electrical dyssynchrony in heart failure (hf) patients with a narrow qrs complexes (≤ 130 ms) using the ecg belt. this is a pilot study that is designed to provide data that can be used in designing and implementing a prospective study of cardiac resynchronization therapy (crt) in narrow qrs patients selected and optimized using the ecg belt.


Eligibility criteria:
inclusion criteria: * subject (or their legal guardian) must be willing to provide informed consent for their participation in the study * subject ≥ 18 years old exclusion criteria: * subject has unhealed-open wounds on the torso and/or has a history of severe allergic reactions from ecg electrode gel * subject is enrolled in a concurrent study that could confound the results of this study * subject is pregnant
implementation of promuscle in daily practice

Conditions: Sarcopenia; Frailty; Aging Problems

Summary: implementation of a previously shown (cost-)effective combined lifestyle intervention for community living older adults, promuscle, in at least four of the eight communities of the 'foodvalley' in the netherlands.

promuscle is a combined lifestyle intervention that has been shown effective in improving muscle mass, muscle strength, and physical functioning in community-dwelling older adults. potentially, it could facilitate older people in maintaining their functional independence. despite the promising results, promuscle is still not part of daily care. previously factors influencing successful implementation were identified and implementation strategies targeting these factors were developed and formatted as an implementation toolbox for healthcare professionals. to increase the likelihood of successful implementation of promuscle, this study aims to investigate the pump-fit strategy (implementation toolbox) effectiveness on the adoption of promuscle in community-care a hybrid type 3 stepped wedge cluster trial with a mixed method analysis will be conducted to assess the effectiveness of the pump-fit implementation toolbox. a stepped wedge trail is chosen because of the ability to compare between clusters, but also within clusters. moreover, promuscle is already found effective, and the researchers hypothesized that the implementation toolbox should be assessable for all healthcare professionals in the 'foodvalley'. at last, a stepped wedge design is recommended if there is limited time and a small sample of professionals to recruit from in comparison to the total sample size that is needed to detect any effect. in addition, the researchers hypothesized that the program would be adapted to specific contexts' outcomes from the recipients of promuscle will be collected. a hybrid type three trial aims to investigate the implementation as a primary outcome and the effect of the (adapted) intervention as a secondary outcome.

Eligibility criteria:
to be eligible to participate in this study, healthcare professionals must met the following criteria: * physical therapist, lifestyle coach or dietician in one of the communities in the foodvalley in the netherlands * interested in combined lifestyle programs for older adults * frequently involved in maintaining physical functioning in older adults in and exclusion criteria for older residents receiving promuscle are: inclusion criteria: * aged 65 years or older * living in one of the eight communities of the 'foodvalley' (ede, wageningen, nijkerk, rhenen, veenendaal, barneveld, scherpenzeel, renswoude) * able to understand dutch * are pre-frail or frail (score 1 or more points on the fried frailty criteria), or report loss of muscle strength exclusion criteria: - one or more red flags for participating in progressive resistance exercise without consent of a medical specialist or general practitioner

Keywords: implementation lifestyle intervention prevention
prevalence of white spot lesions in enamel after orthodontic treatment in young adults

Conditions: White Spot Lesion

Summary: the aim of the study is to measure prevalence of enamel white spot lesions in enamel in young adults after orthodontic treatment.


Eligibility criteria:
inclusion criteria: 1. patients whose age between 18-30 years old consulting in the outpatient clinic. 2. provide informed consent. 3. co-operative patients approving to participate in the trial. 4. both sexes are included 5. egyptian - exclusion criteria: 1. patients under or over this age group. 2. patients with other developmental defect, such as; fluorosis, amelogenesis imperfecta and syndromes associated with enamel formation defects. 3. patient with mih . 4. refuse to participate in the study.
risk factors for pressure ulcers

Conditions: Pressure Ulcers

Summary: development of pressure ulcer (pu) is complex and multifactorial. the association of a constituted pu and of clinical / biological major elements is demonstrated and justifies. prevention of pu is an important health priority, one that requires clear identification of risk factors.


Eligibility criteria:
inclusion criteria: * presenting with at least of a wound and confirmed diagnosis of pu, age≥18 years old, bedridden, not feeds only and without trophic and mental disorders. exclusion criteria: * paediatric study populations, age \> 90 years old, allergy to wound products, malignant origin

Keywords: difficult environmental, microbial, immunological and genetic factors significantly different
total hip arthroplasty (tha) surgical techniques comparing the direct anterior approach to the posterior approach

Conditions: Osteoarthritis of the Hip

Summary: the purpose of this study is to compare the short term effectiveness and return to function of subjects undergoing primary total hip arthroplasty using an anterior approach (incision on the front part of the hip joint) versus posterior approach (incision over back part of the hip joint).

the anterior approach may provide better early post-operative outcomes because there are fewer muscles at the front of the hip so the surgeon works between them rather than cutting through muscle fibers. however, the anterior approach is more difficult to access so usually requires a specialized table. the posterior approach is easier to access, but the incision cuts through muscle fiber. this may lengthen recovery time. however, a specialized table, which can be quite expensive, is often not required.

Eligibility criteria:
inclusion criteria: 1. subject is able to or capable of providing consent to participate in the clinical investigation. 2. subject is between the ages of 20-75 years, inclusive. 3. subject requires a cementless, primary total hip arthroplasty for non-inflammatory degenerative joint disease (nidjd) 4. subject has sufficient bone stock for the hip replacement device. 5. subject is a suitable candidate for the devices specified in the clinical investigation plan and is willing to be randomized to either surgical approach. exclusion criteria: 1. subject in the opinion of the investigator has an existing condition that would compromise his /her participation and follow-up in this investigation. 2. subject has had previous surgery on the affected hip. 3. subject has significant osteoarthritis of the contra-lateral hip requiring a total hip arthroplasty within 12 months.

Keywords: anterior approach posterior approach
plasma circulating deoxyribonucelic acid (dna) as a response marker

Conditions: Head and Neck Cancer; Esophageal Cancer

Summary: this study investigates whether the amount of circulating plasma dna can be used as a response marker for anti-cancer treatment in treating gross tumors.


Eligibility criteria:
inclusion criteria: * head and neck cancers * esophageal cancer * undergoing anti-cancer treatments exclusion criteria: * no distant metastasis

Keywords: plasma circulating dna hean and neck cancers esophageal cancer localized head and neck cancers localized esophageal cancer
comparing clinical outcomes between ketamine-midazolam and morphine-midazolam for continous sedation in icu patients.

Conditions: Critical Illness

Summary: a prospective, double-blinded, multicenter randomized control trial. all critically ill patients above 12 years of age requiring continuous sedation for \>24hrs in the icu will be screened and those meeting selection criteria (and consented) will be enrolled into the study. .

165 participants shall be consecutively randomized into either sedation with ketamine-midazolam or morphine-midazolam group using a block sequence technique; group concealed in brown envelopes. blinding will be at patient/next of kin level as well as investigator/data collector level. enrolled subjects shall be followed up for treatment history, co-morbidities and related data will be collected, results analyzed and study findings will be availed to icu physicians and ministry of health to guide treatment considerations and for health care planning. data shall be collected using a standardized questionnaire by trained research assistants. it will be double entered into epidata and exported to stata version 12.0 for analysis. continuous variables will be expressed as means and standard deviations, while categorical data will be expressed as frequencies with their respective percentages. linear regression and logistic regression used to analyse primary outcomes, as well as multivariate analysis to detect associations.

Eligibility criteria:
inclusion criteria: 1. age \>12years of age. 2. anticipated need for sedation for \>24hours. exclusion criteria: 1. hypertensive crisis i.e. sustained sbp \>200mmhg/dbp\>110mmhg 2. status epilepticus 3. ischemic heart disease and severe lv dysfunction 4. persistent tachyarrythmias 5. history of mental illness 6. hypersensitivity to ketamine, morphine or midazolam. 7. tetanus -due to the muscle rigidity that may be caused by ketamine. reasons for exclusions 1 to 4; ketamine stimulates the sympathetic nervous system causing transient increase in myocardial work and blood pressure and has psychoactive effects
efficacy of premixed nitrous oxide and oxygen in elderly patient with out-of-hospital severe acute pain

Conditions: Pain Acute

Summary: pain in the elderly is poorly evaluated and clearly under treated. premixed nitrous oxide and oxygen is used in the emergency medical care of the trauma, burns, during transport of patient with pain. none randomized study has validated the use of premixed nitrous oxide and oxygen in the emergency department in the elderly. the aim of the study is to demonstrate the efficacy of premixed nitrous oxide and oxygen compared to medical air in elderly patient with out-of-hospital severe acute pain

the primary endpoint is the percentage of patients with pain relief (with a numerical rating scale of 3/10 or lower) 15 minutes after randomisation. secondary endpoints are treatment safety and adverse events, time to analgesia and duration of analgesia. this study will expect 108 patients assigned in two parallel groups, defined by a randomization scheme. four sites will participate to the research. eligible patients with a numeric rating scale (nrs) score higher than 6/10 are randomly allocated to receive either meopa, or medical air. neither the investigator nor the nurse knows the treatment. pain score will be measured at baseline and every 5 minutes until pain relief will be obtained. the safety evaluation will include non invasive monitoring of blood pressure, heart rate, and oxygen saturation by pulse oximetry (spo2) and adverse events collection.

Eligibility criteria:
inclusion criteria: * patients aged 65 years old and over * severe acute pain (nrs score greater than 6) exclusion criteria: * contraindication of premixed 50% nitrous oxide and oxygen

Keywords: premixed nitrous oxide and oxygen severe acute pain prehospital setting
acute effects of cafestol on glucose metabolism in subjects with type-2-diabetes.

Conditions: Diabetes Mellitus, Type 2

Summary: acute, double-blinded, randomized, cross-over cafestol intervention study with sixteen participants with t2d participating in two ogtts.

the study is an acute, double-blinded, randomized, cross-over intervention study with sixteen participants with t2d. initially, a blood sample is obtained (t=-15 min) and at time point 0, the participants will ingest a tablet containing either 12 mg cafestol or placebo. immediately hereafter an ogtt commences with ingestion of a 75 g glucose solution. in the following 3 hours blood samples are collected at time points 0, 15, 30, 60, 90, 120 and 180 min. the samples will be used for determination of plasma glucose, insulin and cafestol, as well as glp-1 and gip. after a one-week washout period, the subject will undergo the same set-up again, however now with the opposite intervention / placebo.

Eligibility criteria:
inclusion criteria: * type 2 diabetes defined by standard danish guidelines * hba1c ≥48 mmol/mol unless successfully treated with antidiabetic drugs and/or diet/exercise intervention exclusion criteria: * in treatment with insulin * pregnancy * planned pregnancy * breastfeeding * significant comorbidity expected to unable the subject from completing visits

Keywords: diabetes mellitus, type 2
pet/mri scan for the evaluation of resectable stage ia1-ib3 cervical cancer

Conditions: Stage IA Cervical Cancer; Stage IA1 Cervical Cancer; Stage IA2 Cervical Cancer; Stage IB Cervical Cancer; Stage IB1 Cervical Cancer; Stage IB2 Cervical Cancer; Stage IB3 Cervical Cancer

Summary: this trial studies how well positron emission tomography/magnetic resonance imaging (pet/mri) scan works in checking patients with stage ia1-ib3 cervical cancer that can be removed by surgery (resectable). pet/mri scan may help doctors learn more about the spread of the disease.

primary objective: i. to assess depth of cervical invasion with positron emission tomography/magnetic resonance imaging (pet/mri) in patients with cervical cancer in clinical federation of gynecology and obstetrics (figo) staging undergoing evaluation for surgical resection and correlate with pathology. secondary objectives: i. to correlate lymph node involvement on pet/mri with pathology. ii. to assess the inter-observer variability in the interpretation of pet/mri. iii. to correlate the quantitative imaging parameters of the tumor, such as the volumetric size, blood oxygen level dependent (bold), intravoxel incoherent motion (ivim) analysis, apparent diffusion coefficient (adc), diffusion tensor imaging (dti), dynamic contrast-enhanced (dce), metabolic tumor volume (mtv), total lesion glycolysis (tlg), standardized uptake value (suv) and the glucose metabolic rate (gmr) with lymphovascular space invasion (lvsi) and tumor grade on surgical pathology. outline: patients receive fludeoxyglucose f-18 and gadobutrol intravenously (iv) over 1 minute and undergo pet/mri over 90-120 minutes.

Eligibility criteria:
inclusion criteria: * all patients with suspected clinical stage ia1-ib3 cervical cancer except patients with tumors \> 4 cm * no contraindications to mri * patients undergoing surgical procedure at md anderson * suspected cervical cancer exclusion criteria: * patients who have contraindication to mri * glomerular filtration rate (gfr) \< 30 * pregnant patients * patients with history of previous radiation * patients with previous surgery for cervical cancer, unless residual tumor noted on physical exam * patients with endometrial cancer extending to the cervix * allergic reaction to gadolinium based contrast * body weight of greater than 450 (181.4 kg) * patients requiring general sedation * extremely claustrophobic patients