Kornimate/medical-research-clean huggingface dataset:
preservation vs. dissection of inferior pulmonary ligament for thoracoscopic upper lobectomy

Conditions: Lung Diseases

Summary: many thoracic surgeons tend to dissect the inferior pulmonary ligament (ipl) during upper lobectomy, which in theory reduces the free space in the upper thoracic cavity by increasing the mobility of the residual lung. however, the dissection of ipl may lead to bronchial deformation, stenosis, obstruction or lobe torsion, and distortion. some studies have found that stenosis might be associated with chronic dry cough and shortness of breath, and could result in a significant decline in lung function. moreover, the dissection of ipl may lead to greater surgical trauma and increase the incidence of complications. therefore, this study tries to identify whether we should dissect or preserve the inferior pulmonary ligament during the thoracoscopic upper lobectomy.


Eligibility criteria:
inclusion criteria: 1. 18 years old \< age \< 70 years old; 2. meet the indications for thoracoscopic left/right upper lobectomy; 3. gave informed consent and were willing to undergo thoracoscopic left/right upper lobectomy; 4. preoperative pulmonary function test: fev1\>1l and fev1\>60% of the predicted value; 5. preoperative ecog score of 0-1; 6. preoperative asa score i-ii. exclusion criteria: 1. inferior mediastinal lymphadenopathy was found in preoperative screening; 2. found that other lobe operations were required at the same time due to multiple lesions in the preoperative discussion; 3. pregnant or lactating women; 4. suffering from severe mental illness; 5. history of thoracic surgery (including intrathoracic surgery only, excluding surface surgery such as mastectomy); 6. history of unstable angina or myocardial infarction within the past six months; 7. history of cerebral infarction or cerebral hemorrhage within the past six months; 8. history of continuous systemic corticosteroid therapy within the past month; 9. abnormal coagulation function, bleeding tendency, or receiving antithrombotic or antiplatelet therapy recently; 10. suffering from severe liver, kidney, and other systemic diseases; 11. other situations that are not suitable for surgery.
reliability and validity of the dips (structured interview) in a community sample

Conditions: Psychological Disease

Summary: the dips (diagnostisches interview bei psychischen störungen) is a structured interview to assess a variety of the most frequent psychological disorders. its reliability and validity has been studied in clinical samples. since structured interviews are also used in non-clinical samples like epidemiological research the investigators would like to conduct a study in a community sample to test the interview's reliability, validity and acceptance.

the dips (diagnostisches interview bei psychischen störungen) is a structured interview to assess a variety of the most frequent psychological disorders. its reliability and validity has been demonstrated in clinical samples. also, studies have tested patients' and therapist's acceptance of the interview. since structured interviews are also used in non-clinical samples like epidemiological research the investigators would like to conduct a study in a community sample to test the interview's reliability, validity and acceptance in this population (study aim 1). the investigators also plan to compare positive mental health and affective styles of the subsample of participants with no current or lifetime mental health illness to patients from the local outpatient treatment center at the ruhr-university bochum, who all reported at least one current mental illness (study aim 2). if the researchers obtain enough participants with no current mental health problem, but a history of at least one mental health illness, they will be included in the analysis for study aim 2 as well. since the data collection takes place during the corona pandemic, participants will also be asked to give information about how they are affected, about their living situation and their media use over the course of half a year to describe the sample and to determine the impact of these factors on the incidence and course of mental illness (study aim 3).

Eligibility criteria:
inclusion criteria: * sufficient knowledge of the german language exclusion criteria: * none

Keywords: clinical interview community sample
healthier living with arthritis online program

Conditions: Osteoarthritis; Rheumatoid Arthritis; Fibromyalgia

Summary: individuals with with arthritic conditions (rheumatoid arthritis, osteoarthritis, or fibromyalgia) and internet and email access were randomized to receive an internet-based arthritis self-management program (treatment group) or to continue with usual care (control group). questionnaires measuring health indicators, health behaviors, self efficacy and health care utilization were administered at baseline, six months and one year after the course. it was hypothesized that those participating in the course would have better outcomes than the control group at six months and one year.

an internet-based arthritis self-management program was developed based on the widely used small-group arthritis self-management program. individuals with arthritis were recruited via established websites, on-line newsletters, discussion groups, calendar announcements and articles in newspapers, and asked to go to the project website. subjects who filled out an informed consent and met all of the following criteria were invited to enroll: 1. at least 18 years of age 2. a physician's diagnosis of osteoarthritis, rheumatoid arthritis or fibromyalgia. 3. not have been in active treatment for cancer for one year. 4. not participated in the small group arthritis self-management or chronic disease self-management program those eligible and wishing to continue were randomized to receive the internet-based arthritis self-management program (treatment group) or to continue with usual care (control group). on-line questionnaires were administered at baseline, six months and twelve months after the program. measures included health indicators, health behaviors, self efficacy and health care utilization. it is hypothesized that course participants, compared to the usual-care control group, will show statistically significant improvements (using analyses of covariance and logistic regressions) in outcome variables and that the improvements will be associated with increased self-efficacy for management of arthritis.

Eligibility criteria:
inclusion criteria: * arthritic condition (osteoarthritis, rheumatoid arthritis or fibromyalgia) * internet access and ability to use computer exclusion criteria: * active treatment for cancer * taken small group arthritis self-management program

Keywords: arthritis self management patient education
comparison of image quality between ultra-low dose (uld) and standard dose ct scans in detecting traumatic brain injury in the emergency room

Conditions: Closed Head Injury; Penetrating Head Injury

Summary: head trauma is a frequent reason for consultation in the emergency room. the ct scan is the reference examination allowing rapid management of the patient. however, ct examinations are among the diagnostic examinations with the highest exposure to ionizing radiation. the study investigators have previously implemented "ultra-low dose" (uld) acquisitions for several pathologies with an effective dose level similar to that of a standard radiographic examination. these uld acquisitions are now routinely used in our clinical practice for explorations of the thorax, spine, pelvis and proximal femurs, extremities. this study expands these uld acquisitions to skull ct for detecting traumatic intracranial lesions. the study investigators hypothesize that it would be possible to search for intracranial lesions in patients with head trauma using uld protocols, thereby reducing the doses delivered to the patient while maintaining sufficient image quality for the diagnosis.


Eligibility criteria:
inclusion criteria: * patient presenting to the emergency room of the chu of nîmes for a cranial trauma requiring scanning. * patient with isolated head injury or polytrauma patient with head injury among others. * the patient or their legal representative or family member must have given their free and informed consent and signed the consent form, or the patient was included under an emergency situation * the patient must be a member or beneficiary of a health insurance plan exclusion criteria: * the subject is participating in a study prohibiting participation in other studies, or is in a period of exclusion determined by a previous study * patient is pregnant, parturient or breastfeeding
topical tranexamic acid and acute blood loss in total hip arthroplasty

Conditions: Acute Blood Loss Anemia; Osteoarthritis, Hip

Summary: this study aims to assess postoperative blood loss and transfusion rates in total hip replacement after one-time administration of topical tranexamic acid.

autologous (donor) blood transfusion is an expensive and common occurrence after total hip replacement. there have been many proposed adjunctive measures to decrease intraoperative and postoperative blood loss during such surgery. most of these include thrombin inhibition, so-called "minimally- invasive" techniques or instrumentation, or other adjunctive drugs. hitherto, tranexamic acid, a specific drug that promotes part of the clotting cascade, has been used extensively in multiple areas of surgery with multiple studies evaluating its efficacy in cardiac surgery, spinal procedures, and as a dental swishing solution after tooth extraction. there have been small studies evaluating intravenous tranexamic acid and its effect on total hip replacements, with some promising results. the topical form of ta has been evaluated in only one prospective, randomized clinical trial with a significant decrease in postoperative blood loss and a trend towards decreased autologous blood transfusion rates. this study proposes to further evaluate tranexamic acid as an inexpensive and viable option for use in total hip arthroplasty. the topical form of the drug has been shown to achieve these hemostatic effects without increasing the risk of blood clots after surgery. a rigorous analysis of the effects of tranexamic acid demand a more standardized approach. such a regimen is practiced at henry ford hospital as all patients on the adult reconstruction service are placed on an identical dose of enoxaparin (a subcutaneous blood thinner) postoperatively for two weeks.

Eligibility criteria:
inclusion criteria: * all adult patients over age eighteen * primary unilateral total hip arthroplasty at henry ford hospital (detroit, michigan, united states) and henry ford west bloomfield hospital (west bloomfield, michigan, united states) exclusion criteria: * patient history of venous thromboembolic disease or coagulopathy * use of anticoagulant medications within 7 days of surgery * history of arterial embolic disease * history of class iii or iv heart failure * renal failure * intraoperative cardiovascular, pulmonary, orthopaedic, or anesthetic complication (mi, intraoperative fracture, vasopressor support, emergent intubation).

Keywords: tranexamic acid blood transfusion total hip arthroplasty
delayed surgery in inflammatory bowel disease

Conditions: Inflammatory Bowel Diseases; Quality of Life; Surgery

Summary: the timing of elective surgery in inflammatory bowel disease (ibd) may be crucial according to progression of the disease. in most cases, medical treatment has failed when surgery is discussed. if treatment with surgery then is delayed, complications may arise, such as fistula, severe inflammation with risk of perforation or stenosis, nutrition problems i.e. this may affect quality of life, and also make the surgery more complicated, with higher risk of per- and postoperative complications. the covid-19 pandemic led to a shift in resources where elective surgery has been postponed. the waiting time for elective surgery for ibd-patients at sahlgrenska university hospital/östra is still affected which might have impact on patient health outcomes as well as health economics, due to the risk of complications and need of emergency and planned care while waiting for surgery. the primary object is to evaluate how long an ibd patient can wait for surgery before affecting health economy and quality of life. in the operation program orbit, we identify all patients with ulcerative colitits (uc) and crohn´s disease (cd) that stands in line for elective surgery (not including dysplasia/cancer). the date when operation was decided is registered including time of delay. patient characteristics are registered in crf, including diagnosis, age and reason for scheduled surgery. number of hospital visits (planned/emergency visits) are registered during time of waiting for surgery. days of sick leave is registered from the swedish social insurance agency. questionnaires are sent to the patients for quality of life and bowel function (eq5d and short health scale). the primary endpoint in the first manuscript is how health economics is affected by the delay of elective care in ibd-patients, due to complications and extensive need of hospital visits while waiting for surgery, costs of medical material (stoma bandage i.e), costs of medical treatment and sick leave rates, including quality of life. patients who have been operated for ibd will form the control group and comparison will be made in terms of complications, hospital visits, costs of medical material and medical treatment and sick leave rates, as well as quality of life.


Eligibility criteria:
inclusion criteria: * inflammatory bowel disease * minimum 18 years old * planned surgery/operated since 2017-2021 at sahlgrenska university hospital exclusion criteria: * cancer surgery
prognostic value of ct dynamic myocardial perfusion in patients with obstructive coronary artery stenosis

Conditions: CT Perfusion

Summary: validity is a prospective, open-label, multicenter, randomized controlled trial （clinicaltrials.gov number）. the study was designed to evaluate the value of noninvasive anatomic cta combined with functional ctp for the next clinical decision making and the added prognostic value of ctp beyond cta.


Eligibility criteria:
inclusion criteria: 1. age ≥18 years. 2. stable chest pain with obstructive coronary stenosis (50-90%) assessed by cta. exclusion criteria: * (1) diagnosed or suspected acute coronary syndrome (acs) requiring hospitalization or urgent or emergent testing; elevated troponin or creatine kinase-myocardial band (ck-mb). (2) hemodynamically or clinically unstable condition systolic blood pressure (bp) \< 90 mmhg, atrial or ventricular arrhythmias, or persistent resting chest pain felt to be ischemic despite adequate therapy. (3) known cad with prior myocardial infarction (mi), percutaneous coronary intervention (pci), coronary artery bypass graft (cabg). (4) known significant congenital, valvular (\> moderate) or cardiomyopathic process (hypertrophic cardiomyopathy or reduced systolic left ventricular function (lvef) ≤ 40%)) which could explain cardiac symptoms. (5) contraindication to undergoing cta, including but not limited to: a. allergy to iodinated contrast agent, b. unable to receive beta blockers, c. creatinine ≥1.7 mg/dl or gfr≤30 ml/min , d. pregnancy. (6) contraindication to atp, including but not limited to: a. ii or iii atrioventricular block, b. bronchial asthma, c. hypotension (sbp\<90mmhg), d. bronchial stenosis or bronchospasm, e. acute myocardial infarction, f. left main stenosis, g. unstable angina, h. allergy to aminophylline. (7) life expectancy \< 2 years. (8) unable to provide written informed consent or participate in long-term follow-up.
performance of an investigational blood glucose monitoring system

Conditions: Diabetes

Summary: the purpose of this study was to demonstrate that untrained subjects who have diabetes can operate the investigational blood glucose monitoring system (bgms) and obtain valid glucose results.


Eligibility criteria:
* inclusion criteria: 1. males and females, 18 years of age or older. 2. people with type 1 or type 2 diabetes. 3. able to speak, read and understand english. 4. willing to complete all study procedures. * exclusion criteria: 1. hemophilia or any other bleeding disorder. 2. pregnancy. 3. physical, visual or neurological impairments that would make the person unable to perform testing with the bgm. 4. previously participated in a blood glucose monitoring study using the ninja 3 plus bgms. 5. working for a medical laboratory, hospital or other clinical setting that involves training on or clinical use of blood glucose meters. 6. working for a competitive medical device company, or having an immediate family member who works for such a company. 7. a condition, which in the opinion of the investigator or designee, would put the person or study conduct at risk.
prospecitve observational study on a risk adaptive scheme for sbrt for thoracic nodes metastases

Conditions: Thoracic Nodes Metastases

Summary: oligometastatic patients with inoperable thoracic nodes metastases from any primary, except for hematologic malignancies, will undergo a risk adaptive scheme of stereotactic body radiation therapy (sbrt).

the observational study is designed to evaluate safety and efficacy of a risk adaptive scheme of stereotactic body radiation therapy (srt) in oligometastatic patients with thoracic nodes metastases, medically inoperable, using vmat rapidarc approach. the potential advantage of this technique is the ability to deliver a more selective irradiation to tumour's target while reducing doses to normal tissue, optimizing the therapeutic window.

Eligibility criteria:
inclusion criteria: * patients aged \>18 years with ecog 0-2 * karnofsky index \> 70% (ecog \>2) * any primary, except for hematologic malignancies * dfi (disease-free interval) from diagnosis \> 6 months * unresectable lesions or inoperable patients or patients who refused surgery * less than 3 metastatic thoracic nodes * no extrathoracic disease or other metastatic sites stable or responding after chemotherapy, with less than 5 metastatic sites * no life threatening conditions * chemotherapy completed at least 1 week before treatment * chemotherapy started at least 1 week after treatment allowed * systemic therapies other than chemotherapy allowed (i.e hormonal therapies and/or immunotherapy) * written informed consent exclusion criteria: * previous rt in the same region * pregnant women * patients with inability to consent
circadian ra study in rheumatoid arthritis subjects

Conditions: Rheumatoid Arthritis

Summary: primary objective: to determine the changes in circadian activity rhythms and disease activity in rheumatoid arthritis (ra) patients from pre-treatment to one month after enbrel initiation. secondary objectives: * to determine if there is an association between changes in circadian rhythm and changes in disease activity in active ra after initiation of enbrel * to determine if the changes in circadian activity rhythms are associated with systemic inflammation in ra patients * to determine changes in traditional sleep quality variables from pre-treatment to one month after enbrel initiation in ra patients

rheumatoid arthritis (ra) is a chronic and debilitating disease. however, the symptoms of ra show variation over the course of the day, with worsening symptoms in the morning. this worsening of symptoms in the morning is correlated with an increase in inflammation in the body. biologic therapies, such as enbrel (etanercept), appear to improve energy, pain and quality of life in patients with ra, and these changes may occur before a doctor is able to detect changes during the patient's physical examination. it is possible that a patient's response to biological agents can be rapidly determined by assessing circadian activity (also called "rest-activity circadian rhythms" or rar). currently, wrist actigraphy bands, which are worn for a period of time, can reliably provide information about rar. wrist actigraphy bands are small electronic devices worn on the wrist (similar to a watch) that records the subject's level of activity throughout the day. studies in osteoarthritis and in rheumatoid arthritis have found subjects with joint pain to have significant differences in rar, and disrupted rar has been associated with disease activity. this study will provide information about 24-hour circadian activity rhythms before and after 3-4 weeks of enbrel treatment in study subjects with active rheumatoid arthritis. the study will assess patients who are starting on enbrel that has been prescribed by their doctor.

Eligibility criteria:
inclusion criteria: * 6/28 tender and 6/28 swollen joints (e.g. active rheumatoid arthritis) * crp ≥ 1.5mg/l * insufficient response or intolerance to ≥1 disease modifying anti-rheumatic drug (dmard) which must include methotrexate or hydroxychloroquine, or sulfasalazine or leflunomide and at stable dose for 4 weeks * if taking glucocorticoids, stable dose from 0-10mg a day for 2 weeks, and remain stable for the 4 week study * appropriate to start on a biologic agent for ra, as determined by patient's physician. exclusion criteria: * prior use of a biologic agent for 4 weeks prior to the study * evidence of positive tuberculosis (tb) test, purified protein derivative (ppd) or quantiferon or prophylactic treatment instituted 4 weeks before study, or hepatitis b core antibody * no medical condition that would prevent completion of the study
quality of life of colorectal cancer screenees in the period between colonoscopy and next clinic visit for final report: does real-time endoscopic optical diagnosis improve their quality of life

Conditions: Colorectal Neoplasms; Colonoscopy; Quality of Life; Mass Screening; Anxiety

Summary: colorectal cancer screening program has been proven to reduce colorectal cancer (crc) mortality and is cost-effective. it has been adopted by most countries in the world, and colonoscopy is regarded as the most accurate test for detecting colorectal neoplasm. after screenees underwent colonoscopy, most endoscopists do not routinely explain the preliminary optical diagnosis to the subjects before they going home, which may cause unnecessary anxiety and may reduce the quality of life of the subjects before acquiring the final results. in recent years, endoscopic optical diagnostic technology has been validated by meta-analysis studies as an excellent tool to predict the histology of colorectal polyps and to differentiate the invasion depth of colorectal cancer. the real time feature of endoscopic optical diagnosis allows endoscopists to explain the preliminary results confidently to the subjects immediately after colonoscopy, which is expected to reduce the anxiety of the subjects before they acquired the final results and improve their quality of life. we designed a randomized controlled trial to validate whether real-time endoscopic optical diagnosis could decrease the anxiety burden and improve the quality of life for colorectal-cancer screenees after colonoscopy.


Eligibility criteria:
inclusion criteria: * patients who preparing to received screening or surveillance colonoscopy under general anesthesia. * patients who preparing to received sedated colonoscopy due to other gi tract related symptoms. exclusion criteria: * impaired mental status that could not understand the questionnaire questions. * patients with major psychological disorders.

Keywords: colorectal neoplasms colonoscopy quality of life mass screening anxiety