Kornimate/medical-research-clean huggingface dataset:
impact of availability of showerpatch for patients with intravenous catheters

Conditions: Cystic Fibrosis; Pulmonary Hypertension; Neoplasms

Summary: venous catheters are necessary for the treatment of many patients. showering with a venous catheter is often prohibited due to the infection risk when the insertion site becomes wet. therefore these patients are challenged to keep the catheter insertion site dry and always covered with a dressing. washing themselves is often impossible without assistance of a nurse or significant other. for patients with a catheter connected to an infusion line, it is even more difficult. showerpatch is a newly developed dressing that safeguards the insertion site of an iv catheter from water during bathing activities. the purpose of this trial is to evaluate the impact of the availability of showerpatch by comparing the outcomes in patients regarding the patient's autonomy in bathing activities, the material use and the time needed from caregivers in home care. additionally qualitative data on patient's bathing activities and the use of showerpatch will be collected.


Eligibility criteria:
inclusion criteria: * able to read and speak dutch and to fill out a web-based questionnaire * patients with an iv catheter (peripheral catheter, midline, peripherally inserted central catheter (picc), central venous catheter (cvc), tunnelled catheter or implantable port) with an expected dwell time iv therapy of at least 14 days and with or without a prospect of discharge to the home setting with the iv catheter in situ in the foreseen study period * physically able to wash themselves * with access to the internet exclusion criteria: * bedridden patients * patients who have already participated in an earlier stage of the isic study * patients with more than one lumen of the catheter continuously connected to an infusion line

Keywords: bandages catheter
investigation of the relationship of pain perception and pain belief with age in people with chronic lack pain

Conditions: Chronic Pain; Low Back Pain

Summary: this study was planned to investigate the relationship between pain perceptions and pain beliefs of individuals in different age groups with chronic low back pain and symptom severity.

the study will be conducted as an observational descriptive and cross-sectional research. participants will be recruited after the purpose and content of the research are explained by the researchers, their written consent is read, and the volunteers who agree to be included in the study are given their written consent. the data collection process was carried out face-to-face and via a google forms survey over the internet, and will be conducted with the participants face-to-face and online. in the study; the pain beliefs questionnaire (pbq), the centrality of pain scale (cops) and the numerical rating scale (nrs-11) will be used.

Eligibility criteria:
inclusion criteria: * having low back pain for at least the past three months * be between the ages of 18-79. exclusion criteria: * those outside the age limit of 18-79 and illiteracy.

Keywords: pain perception pain beliefs
a study to evaluate the effectiveness and safety of rxi-109 on the outcome of keloid excision surgery in healthy adults

Conditions: Keloid

Summary: to evaluate the effectiveness of rxi-109 in reducing the recurrence of keloid formation following elective keloid excision.


Eligibility criteria:
inclusion criteria: * adults, 21-55 years of age. * two keloids of approximately similar size and anatomical location on the earlobe, neck, or torso. * keloids to be excised must have been present for \> 1 year. exclusion criteria: * use of tobacco or nicotine-containing products * pregnant or lactating * post-menopausal or full hysterectomy

Keywords: keloid cicatrix keloid prevention keloid revision/excision keloidectomy
outcome of three controlled ovarian hyperstimulation protocols in poor responding infertility patients

Conditions: Infertility

Summary: there are different controlled ovarian hyperstimulation protocols utilized in infertility patients. in this study, our aim is to specifically compare three protocols in poor responding infertility patients.


Eligibility criteria:
inclusion criteria: * patients will be considered eligible if they are poor ovarian responders according to the bologna criteria (ferraretti et al., 2011). * two out of three of the following criteria are essential in order to classify a patient as poor ovarian responder: * advanced maternal age (≥40 years) or any other risk factor for poor ovarian response; * a poor ovarian response (≤3 oocytes with a conventional stimulation protocol); or * an abnormal ovarian reserve test (antral follicle count, \<7 follicles or anti-mullerian hormone, \<1.1 ng/ml).

Keywords: poor responders
multidisciplinary approach to reduce cardiovascular health disparities

Conditions: Acute Coronary Syndrome; Multi Vessel Coronary Artery Disease; Ischemic Stroke

Summary: the goal of this observational study is to investigate the potential differences in thrombogenicity between black and white patients admitted with atherothrombotic events including acute coronary syndrome, multi-vessel coronary disease, and ischemic stroke. participants will engage in laboratory testing and health outcome assessments.


Eligibility criteria:
inclusion criteria: * patients ≥18 years of age admitted with acs, ais, or multi-vessel cad * competent mental condition to provide informed consent and able to participate in follow-ups exclusion criteria: * pregnant women * currently enrolled in an investigational drug or device trial * undergoing treatment for neoplastic, autoimmune, or connective tissue disease * covid-19 infection within 30 days of enrollment * known history of hepatitis or hiv * deemed unfit to participate according to the investigator * known history of drug abuse * known platelet count of \<100,000/mm3 * hematocrit \< 25%
evaluation of personalized nutritional intervention on wound healing of cutaneous ulcers in diabetics

Conditions: Foot, Diabetic

Summary: the ageing population and the increase in diabetes raise the prevalence of chronic skin ulcers (ccu). in diabetics, precursor cell mobilization decreases. in wounds, the inflammation is prolonged and oxidative stress increases. this is an unfavorable microenvironment for healing. a major risk factor in the development of ccu is nutritional deficiency. healing needs energy and nutrients for regeneration. in diabetics the malnutrition can be more than 60%. however, although the provision of certain nutrients can improve the healing capacity, it is not a common clinical practice to nutritionally evaluate diabetic with ccu. exosomes are extracellular vesicles that reflect the physiological state of the cells producing them. stem cell derivatives exosomes are rich in factors, that can provide a favorable microenvironment for tissue regeneration. the aim of this project is to develop a therapeutic process to accelerate the healing of diabetic ccu, based on the correction of nutritional deficiencies, to improve the regenerative capacity, together with the application of exosomes from mesenchymal stem-cell (msc) in the wound, creating a microenvironment that favors tissue regeneration. for this, a pilot clinical trial with diabetic patients with ccu is proposed, to evaluate the effect of personalized nutritional supplementation on healing and regenerative capacity.


Eligibility criteria:
inclusion criteria: * signature of the informed consent * age between 50 and 80 years * diagnosis of diabetes mellitus for more than 1 year * documented diagnosis of peripheral artery disease * hba1c \< 9% * category 5 in the rutherford-becker classification exclusion criteria: * poor cognitive function, dementia or psychiatric conditions * osteomyelitis, gangrene, malignancy or immunocompromised disease * thromboangiitis obliterans or buerger's disease * clinical evidence of invasive infection in the target limb requiring iv antibiotherapy * presence of neuropathic ulcers only * human immunodeficiency virus (hiv), hepatitis c virus (hcv) or hepatitis b virus (hbv) positive.

Keywords: dietary supplementations wound healing diabetes mellitus malnutrition
augmented pacing for shock in the cardiac intensive care unit

Conditions: Cardiogenic Shock; Bradycardia; Shock

Summary: the goal of this clinical trial is to learn if backup pacing at an increased rate improves hemodynamics in adults with relative bradycardia, a permanent pacemaker, and cardiogenic shock. the main question it aims to answer is: does increasing the backup pacing rate to 100 beats per minute lead to improved cardiac index compared to a backup pacing rate of 75 beats per minute participants who are already hospitalized in the cardiovascular intensive care unit with a permanent pacemaker and pulmonary artery catheter in place will be enrolled in this study. participants will be exposed to each pacemaker rate in a randomized order with hemodynamics assessed after 10 minutes at each rate.


Eligibility criteria:
inclusion criteria: * adults (age 18 and older) * located in the cvicu * fda approved permanent pacemaker in place (inclusive of dual-chamber and bi-ventricular icds) with labeling that allows backup pacing setting at 100 bpm. * receiving a vasopressor or inotrope for at least 4 hours * average hr ≤ 75 bpm over the last hour (on telemetry review) * pulmonary artery catheter in place with functioning thermistor and pulmonary artery port. exclusion criteria: * single chamber implantable cardiac defibrillator * sinus rhythm with a leadless pacemaker * ventricular tachycardia or ventricular fibrillation arrest in last 48 hours * hemodynamic instability within the last 4 hours, defined as an increase in the dose of norepinephrine \> 10 mcg/min, an increase of epinephrine \> 10 mcg/kg/min, or initiation of a second vasopressor * alternative indication for pacing rate change (i.e torsade de pointes, recurrent ventricular tachycardia) * comfort-focused care or anticipated death within 24 hours * mechanical circulatory support in place * newly discovered pacing system malfunction (lead displacement, loss of capture, elevated capture threshold, significant lead impedance change, battery depletion, undersensing or oversensing) * non-english speaking

Keywords: cardiogenic shock bradycardia shock pacing
histological analysis of sacrococcygeal pilonidal sinus specimens

Conditions: Pathology

Summary: minimally invasive techniques have been widely used routinely and reliably in the treatment of pilonidal sinus. in some of these methods, the cavity of sinus remains in the patient; this condition caused us to question the necessity of pathological examination. except for prolonged duration of disease, elderly age, macroscopic suspicion, and recurrence; we think that routine pathological examination of the pilonidal sinus is unnecessary.

pilonidal sinus is a benign disease. in the histopathological examination of pilonidal sinus specimens, malignancy can be detected rarely. minimally invasive techniques have been widely used routinely and reliably in the treatment of pilonidal sinus. in some of these methods, the cavity of sinus remains in the patient; this condition caused us to question the necessity of pathological examination. the investigators aimed to discuss the pathological findings of patients who were operated for pilonidal sinus in our clinic in light of the literature. the fact that the rate of malignancy in the literature does not show parallelism with minimally invasive procedures that pathology samples are not taken and whose applications are increasing supports this prediction. except for prolonged duration of disease, elderly age, macroscopic suspicion, and recurrence; the investigators think that routine pathological examination of the pilonidal sinus is unnecessary.

Eligibility criteria:
inclusion criteria: * sacrococcygeal pilonidal sinus exclusion criteria: * non-sacrococcygeal pilonidal sinus * minimally invasive treatment without histopathological examination

Keywords: pilonidal sinus carcinoma pathology squamous cell carcinoma phenol
a brief intervention for chronic pain in primary care

Conditions: Chronic Pain

Summary: the purpose of this research study is to investigate potential benefits of a behavioral intervention for co-occurring chronic pain and distress that is delivered in a primary care clinic.


Eligibility criteria:
inclusion criteria: * chronic pain condition * a current patient within the henry ford health system academic internal medicine clinic in detroit * has been within the henry ford health system for at least 6 months exclusion criteria: * current behavioral health treatment
a safety and efficacy study of anti-inflammatory (canakinumab) and cartilage stimulating (lna043) drugs injected into the knee joint of participants with knee osteoarthritis (oa)

Conditions: Knee Osteoarthritis

Summary: the study will establish safety and efficacy of canakinumab and lna043 in patients with knee osteoarthritis (oa).


Eligibility criteria:
inclusion criteria: * moderate to severe oa pain (corresponding to nrs pain ≥5 to ≤9) in the target knee for the majority of days in the last 3 months prior to screening * koos pain subscale \<60 for the target knee during screening * high sensitivity c-reactive protein (hscrp) ≥1.8 mg/l * radiographic kl grade 2 to 4 knee oa and joint space width (jsw) 2.0-4.0 mm (men) or 1.5-3.5 mm (women) in the medial tibiofemoral compartment (tfc) in the target knee * contrast-enhanced mri (ce-mri) diagnosed moderate or severe knee synovitis based on an established synovititis scoring system (moderate score 9-12 or severe score ≥13) exclusion criteria: * history of, or planned; knee replacement (partial or total) in either knee; arthroscopy or lavage in either knee within 6 months prior to screening; any other previous surgical intervention in the target knee, or for the contralateral knee within 12 months prior to screening, including mosaicplasty, microfracture, meniscectomy \>50% or osteotomy * moderate to severe pain in the contralateral knee for the majority of days in the last 3 months prior to screening * malalignment \>7.5° in the target knee (either varus or valgus) * any diagnosis of systemic inflammatory arthritis or connective tissue disease, including but not limited to rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, gout, paget's disease, systemic lupus erythematosus) or other systemic condition that might confound assessment of oa (e.g. fibromyalgia) * ipsilateral hip oa or hip prosthesis recently implanted (within 1 year prior to screening) or hip replacement on either side planned within the study period

Keywords: canakinumab lna043 knee osteoarthritis oa joint pain cartilage mri dce-mri koos nrs pain ipaq
transcoronary infusion of cardiac progenitor cells in pediatric dilated cardiomyopathy

Conditions: Dilated Cardiomyopathy

Summary: a phase 1 prospective study to determine the procedural feasibility and safety and preliminary efficacy of intracoronary infusion of cardiosphere-derived cells (cdcs) in patients with dilated cardiomyopathy.

five consecutive patients will be enrolled to a phase 1 study to verify the procedural feasibility and safety with the cdc infusion group.

Eligibility criteria:
inclusion criteria: * patients diagnosed as dilated cardiomyopathy. * patients aged under 18 years old. * cardiac ejection fraction \< 40%. exclusion criteria: * contradiction to cardiac magnetic resonance imaging. * cardiogenic shock. * a patient with unstoppable extracorporeal circulation. * a patient with lethal, uncontrollable arrhythmia. * a patient with a complication of coronary artery disease. * a patient with a complication of brain dysfunction due to circulatory failure. * a patient with malignant neoplasm. * a patient with a complication of a serious neurologic disorder. * a patient with high-grade pulmonary embolism or pulmonary hypertension. * a patient with high-grade renal failure. * a patient with multiple organ failure. * active infection (including endocarditis). * sepsis. * active hemorrhagic disease (e.g. gastrointestinal bleeding, injury).
evaluation of the clinical significance of fluorescence videoangiography with indocyanine-green

Conditions: Peripheral Vascular Disease; Microcirculation; Ischemia

Summary: the aim of the study is to compare the diagnostic value of this non-invasive vascular imaging tool with the established vascular diagnostic methods for pad in order to get prognostic data. a higher sensitivity of fluorescence angiography in order to recognize progression of critical limb ischemia could lead to earlier therapeutic interventions and thereby increase limb salvage. a diagnostic gap would be closed.

critical limb ischemia (cli) occurs when the peripheral microcirculation is impaired by arterial stenoses or occlusions. in opposite to earlier studies that only evaluated intermittent claudication due to peripheral arterial disease (pad), rest pain and trophic changes in the affected extremity are due to reduced microcirculation. though the main reason for cli is the existing pad, many processes responsible for pain and other pad-associated symptoms are triggered by a reduced microcirculation so that attempts to enhance the dermal perfusion by pharmacological or other manipulations may ameliorate the results of vascular treatment. these attempts may be the best options for patients, in which vascular surgery was not successful or primarily impossible. a laser-induced fluorescence videoangiography is currently being used in ophthalmology to display the vessels of the eye background. due to technical improvements, it has become a standard procedure. this trial aims at establishing laser-induced fluorescence videoangiography as standard procedure in vascular surgery. this would be of benefit for the patient as the technique does not require the use of ionising radiation and is possible for patients suffering to renal failure.

Eligibility criteria:
inclusion criteria: * patient \> 18 years * chronical ischemia of extremities, rutherford categories 4, 5 and 6 with indication for vascular reconstruction * acute danger of extremity loss due tue ischemia with indication for vascular surgery exclusion criteria: * patient \< 18 years * informed consent not signed * patient has a mrsa infection * patient has an iodine allergy * pregnant female patient * known anaphylactic reactions after injections of contrast media or indocyanine green

Keywords: peripheral vascular diseases microcirculation fluorescence angiography
hiv reverse cholesterol transport study

Conditions: HIV; Dyslipidemia

Summary: primary objective: to examine changes in expression of genes \[particularly abca1 and srebp2\] involved in reverse cholesterol transport (rct) in monocytes from hiv-infected subjects starting antiretroviral therapy and the different effect of nnrti and pi based regimens secondary objective: to examine changes in monocyte intracellular cholesterol content in hiv-infected subjects starting antiretroviral therapy and the different effect of nnrti and pi based regimens

hiv infection is associated with low hdl-cholesterol, an independent risk-factor for cardiovascular disease (cvd). nnrti-based haart increases hdl-c, with nevirapine shown to increase production of its major apolipoprotein apoa-i. in contrast, initiation of pi-based haart leads to persistently low hdl-c despite a reduction in hiv rna and immunologic recovery. hdl-c is formed through reverse cholesterol transport (rct), the process where cholesterol is transferred from intracellular pools to circulating lipoproteins which are then eliminated by the liver. accumulation of intracellular cholesterol in cells such as macrophages and their precursor (circulating monocytes) has been implicated in atherogenesis. in vitro data suggests the hiv protein nef directly interferes with cellular proteins involved in rct such as atp-binding cassette transporter a1 (abca1) in monocyte-derived macrophages. abca1 expression is controlled by peroxisome proliferator-activated receptor gamma (pparg) and the intracellular cholesterol sensor sterol regulatory element binding protein 2 (srebp2). in adipose tissue it is known that pi treatment downregulates srebp and pparg expression. preliminary work in the investigators lab has reproduced these findings in monocytes in untreated hiv infection in vivo and demonstrated relationships between gene expression for abca1, srebp2, monocyte intracellular cholesterol and circulating lipoproteins. these early data suggest that defects in rct determine intracellular cholesterol levels in hiv-infected subjects whereas increased ldl-c is a greater determinant of intracellular cholesterol in hiv negative subjects. this suggests a potentially pivotal role for rct abnormalities in low hdl-c, increased intracellular cholesterol and atherogenesis in hiv infection. the investigator's aim to examine the impact of initiation of art with either pi or nnrti on rct in circulating monocytes in vivo and how this impact correlates with changes in amount and size of circulating hdl-c.

Eligibility criteria:
inclusion criteria: * \> 18 years old * hiv-infected * not currently on antiretroviral therapy (\>6/12), but about to start exclusion criteria: * on lipid lowering medication (statin / fibrate / niacin) * hcv ab+
monthly follow up of interferon gamma releasing assay (igra) among health-care workers treating tuberculosis (tb) patients

Conditions: Tuberculosis

Summary: interferon gamma releasing assay(igra) is useful to diagnose latent tuberculosis. however,igra responses could show within-subject variability. we wanted to determine long-term igra variability in health-care workers who continuously expose to tuberculosis patients.

igra will be performed monthly in health-care workers with continuous exposure to tuberculosis patients for 1 year.

Eligibility criteria:
inclusion criteria: * health care workers who are continuously exposed to tb patients age \> 20 years exclusion criteria: * pregnant active tb use of immunosuppressants

Keywords: igra variability long-term variability of igra