Kornimate/medical-research-clean huggingface dataset:
predictive factors of clinical, laboratory and imaging findings routinely used in diagnosing thyroid cancer

Conditions: Thyroid Cancer

Summary: the purpose of this study is to describe the correlation between the cytohistology exam of patients undergoing thyroid surgery, and the predictive values of: suspicious clinical findings, preoperative thyroid imaging, and the incidence of thyroid cancer in cytologically negative nodes.


Eligibility criteria:
inclusion criteria: * consecutive patients presenting for thyroid disease (palpable nodules) * indication for surgery * age \> 18 years * signed informed consent for surgery * signed informed consent for data collection exclusion criteria: * concurrent condition that contraindicates surgery * clinical or radiologic evidence of locally advanced tumor * clinical or radiologic evidence of metastatic lymph nodes or distant metastases * nonpalpable nodes

Keywords: diagnosis nodules fine needle aspiration
minimally invasive lung surgery under eras with completely tubeless protocol compared with that with partially tubeless protocol

Conditions: Lung Diseases; ERAS; Surgery

Summary: previous studies have shown the feasibility of eras on minimally invasive lung surgery, but it is unknown whether completely tubeless protocol is safe and better. this study aimed to determine whether completely tubeless protocol is feasible and beneficial for minimally invasive lung surgery, compared with partially tubeless protocol.


Eligibility criteria:
inclusion criteria: (i) wedge resection or sub-lobar resection or lobectomy is considered as the primary surgical strategy. the operation ideally should not exceed 2 hours; (ii) no absolute age limit; (iii) patients with eastern cooperative oncology group (ecog) physical performance score of ≤2 points; (iv) p a t i e n t s w i t h a n a m e r i c a n s o c i e t y o f anesthesiologists standard (asa) grade of ≤ iii; (v) body mass index (bmi) \ 50% and ejection fraction (ef) \>50% of predicted value\]. resting blood gas analysis showing arterial partial pressure of oxygen (pao2)≥75 mmhg and arterial partial pressure of carbon dioxide (paco2) \<45 mmhg; (viii) normal renal function and no history of urological problems. exclusion criteria: (i) patient-related factors: (i) patients who refuse surgery and/or the anesthesia protocols; (ii) coagulopathy, hypoxemia (pao2 \ 50 mmhg\], or elevated risk of regurgitation (\<6 hours of fasting) preoperatively or combined with gastroesophageal reflux disease; neurological disorders; (iii) severe acute pulmonary infection or tuberculosis; (iv) relative contraindications: upper airway secretions or persistent cough, spinal deformity, or brain edema (if thoracic epidural anesthesia is to be used); (v) history of ipsilateral surgery and other conditions which can result in extensive pleural adhesion; (vi) phrenic nerve paralysis on the non-operated side should be viewed as a contraindication to vats; (vii) history of urological conditions increasing the need for urinary catheterization; (viii) significant cardiac history. (ii) anesthesia-related factors: (i) allergy to local anesthesia; (ii) any contraindication to the regional anesthesia.

Keywords: tubeless enhanced recovery after surgery (eras) lung surgery no intubation urinary catheter
telemedicine and social media for people who inject drugs (pwid) in greece

Conditions: Drug Abuse, Intravenous; Internet; Social Media; Telemedicine

Summary: the current study seeks to address questions regarding internet and social media usage as well as telemedicine concept and knowledge, by conducting targeted focus group discussions (fgds) and administering cross-sectional questionnaires among pwid in greece. further parameters, such as perceptions for high-quality healthcare access, confidentiality, privacy, and security, will also be explored.

the study's aim is to access the feasibility, acceptability and accessibility of social media and telemedicine as methods to obtain healthcare, in order to improve linkage-to-care among greek substance users. underserved populations, such as people who inject drugs (pwid) have limited access to healthcare and a potential solution to expanding healthcare access points is telemedicine. for the past decade, the investigators have studied the efficacy of a facilitated telemedicine model for hepatitis c virus (hcv) treatment integrated into opioid treatment programs (otps) for pwids. the investigators have achieved high rates of hcv resolution and high patient-satisfaction through facilitated telemedicine. the investigators now seek to explore whether this same intervention might be feasible and acceptable in greece. the first step is to capture and explore the current knowledge, experiences, believes, perceptions and attitudes of pwid in greece regarding internet and social media usage and telemedicine concept, through targeted focus group discussions (fgds) and administration of cross-sectional questionnaire. the perceptions for high-quality healthcare, confidentiality, privacy and security matters will also be explored as well as further relevant attributes.

Eligibility criteria:
inclusion criteria for the fdgs: * \>18 years old * pwid * willing and able to provide informed consent and participate * fluent in greek spoken language * internet access inclusion criteria for the cross-sectional questionnaire: * \>18 years old * pwid * willing and able to provide informed consent and participate * fluent in greek spoken language exclusion criteria for fgd and cross-sectional questionnaire: * \<18 years old * unable/unwilling to consent * legally incompetent
efficacy of imatinib mesylate in hypereosinophilic syndromes

Conditions: Hypereosinophilic Syndrome; Chronic Eosinophilic Leukemia; Chronic Idiopathic Hypereosinophilia

Summary: the study was performed to assess: 1) clinical activity of imatinib in patients with hes, cel and cih; 2) correlation between imatinib activity and specific disease subtype; 3) long-term outcome of hes, cel and cih patients treated with imatinib; 4) safety and tolerability of imatinib administration.

hypereosinophilic syndrome (hes), chronic eosinophilic leukaemia (cel) and chronic idiopathic hypereosinophilia (cih) are rare disorders characterized by chronic hypereosinophilia with possible damage to various organs due to eosinophilic infiltration and release of cytokines. the therapies of these diseases are largely unsatisfactory and based on the use of a variety of antiproliferative drugs such as corticosteroids, interferon-alfa, cyclosporine, vincristine or hydroxyurea. more often the responses are transient and patients need numerous treatment lines. in 2001 schaller et al reported the first case of a patient with hes resistant to conventional treatment that responded to imatinib mesylate. (schaller, mgm 2001). after that, many authors described cases with hypereosinophilia that achieve a rapid response to imatinib and in 2003 cools et al identified a novel tyrosine kinase generated from the fusion of the fip1-like 1 (fip1l1) gene to the pdgfralfa gene associated to hypereosinophilia. the optimal dose of imatinib in this setting of patients is still unknown; however, the demonstration of effective and safe clinical doses in a variety of currently studied malignant diseases, suggests that a dose of 100 mg/day increasing weekly of 100 mg/day (maximum dose 400 mg/day), may be employed. we designed a phase ii trial to investigate the clinical anti-proliferative activity, safety and tolerability of escalating doses of imatinib (entry dose 100 mg/d)administered for 12 total weeks in hes, cel and cih patients.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of hes, cel and cih, who are either previously untreated or have been treated with corticosteroids, cytotoxic drugs, and ifn. * age \> 15 years. * signature of a written informed consent(by parents/tutors for patients aged \< 18 years). exclusion criteria: * patients with a diagnosis of secondary hypereosinophilia * age \< 15 years

Keywords: hypereosinophilic syndrome (hes) chronic eosinophilic leukaemia (cel) chronic idiopathic hypereosinophilia (cih) imatinib response timing to response
anorectal dysfunction in patients suffering from spina bifida : from clinic to neuro-epithelial function (anospin)

Conditions: Spina Bifida

Summary: the purpose of this study is to assess and explain (at least apart) anorectal disorders of patients with spina bifida by an automatic neuropathy responsive of enteric nervous system and epithelial barrier dysfunctions. the investigators' aim hypothetics is that autonomic neuropathy of patients with spina bifida induce enteric nervous sytem and epithelial barrier dysfunctions which explain anorectal disorders of these patients. thexpect to show a decreased of 5% of enteric neurons per ganglia.

spina bifida is rare disease related to a failure of the closure of neural tube during the embryonic period. this malformation results in a variety of clinical disorders (neurologic, urologic, orthopedic, anorectal), depending on the level of the spinal cord lesion. anorectal functional disorders remain underestimated and unknown from a pathophysiological point of view with subsequent uncodified therapeutic strategy. patients with spina bifida always present autonomic neuropathy that contributes partially to the anorectal disorders. these disorders may be related to a closed relationship between autonomic and enteric nervous system. both nervous systems play a key role in anorectal disorders during others neurological disaeses have a common and simultaneous development from neural crest and induce colonic epithelial changes related to the closed connection between epithelial barrier and enteric nervous system. all of this remains hypothetic because no data regarding the impairment of enteric nervous system and epithelial barrier are available and no study are ongoing on this topic.

Eligibility criteria:
inclusion criteria: * patient aged between 18 and 65 years old * patient who consulted to the national spina bifida center for multidisciplinary assessment or for a proctology/urologic clinic * need of colonic biopsies during endoscopy * free, written and informed consent exclusion criteria: * pregnancy or breastfeeding * protected adults (judicial protection, guardianship and truesteeship) and persons deprived of liberty * patient unable to giving their consent * anticoagulants therapy or coagulation disorders

Keywords: enteric nervous system anorectal disorder barostat anorectal physiology spina bifida
effects of tdcs versus hd-tdcs for stroke rehabilitation

Conditions: Chronic Aphasia

Summary: the purpose of this study is to assess the changes in language processing of patients with chronic aphasia after receiving non-invasive brain stimulation.previous research using traditional transcranial direct current stimulation (tdcs) using 2 sponge electrodes has shown that persons with aphasia show more improvement after treatment when that treatment is accompanied by brain stimulation. traditional tdcs has recently been modified to deliver current to more specific locations in the brain. this new delivery method is called high-definition tdcs (hd-tdcs). it is not known whether traditional tdcs (more diffuse current delivery) or hd-tdcs (more focal current delivery) will be the better approach for enhancing treatment outcomes. to answer this question, computerized speech-language treatment will be administered during the application of the different forms of brain stimulation.


Eligibility criteria:
inclusion criteria: 1. one-time ischemic stroke in the left hemisphere 2. greater than 6-months post-stroke onset 3. between 25 and 80 years of age 4. aphasia diagnosis (as determined by pre-treatment language-based testing) 5. right-handed (before the stroke) 6. native speaker of english 7. ability to provide informed written or verbal consent exclusion criteria: 1. clinically reported history of dementia, alcohol abuse, psychiatric disorder, traumatic brain injury, or extensive visual acuity or visual-spatial problems 2. factors contraindicative of tdcs administration (sensitive scalp, previous brain surgery) 3. prior history of epileptic or unprovoked seizures occurring during the previous 12 months.

Keywords: stroke anomia
a 2 period cross-over pharmacokinetic study of sb204 in acne vulgaris

Conditions: Acne Vulgaris

Summary: this study will identify how much (if any) drug is absorbed from the skin of subjects with acne vulgaris after topical application of sb204.

this is a single-center, double-blind, randomized, 2 period cross-over study to be conducted in 18 subjects (18 years of age and above) each of whom will receive sb204 8% and vehicle gel. subjects who satisfy the entry criteria will be randomized to sb204 8% or vehicle gel in a 1:1 ratio for the first treatment period. study drug will be applied to the face, upper chest, upper back and shoulders (approximately 17% bsa) twice daily on days 1- 4 approximately 12 hours apart. on day 5, the study drug will be applied to the same areas only once, in the morning. pharmacokinetic (pk) profiling will be performed on day 1 and day 5. after a wash out period, subjects will be treated with the alternate product and undergo similar treatment and assessments. the primary assessment is the pharmacokinetic profile of nitrate and silicon as markers for systemic exposure to nitric oxide (nitrate) and nvn1000 (silicon) after topical application of sb204 8% to approximately 17% of the total body surface area.

Eligibility criteria:
inclusion criteria: * male and female subjects with an acne severity of moderate or severe and a minimum of 20 inflammatory and 20 non-inflammatory lesions on the face, trunk and shoulders * 18 years of age and older exclusion criteria: * any subject with skin disorders of an acute or chronic nature including psoriasis, eczema, tinea versicolor, etc. * subjects who smoke or use tobacco products * subjects with methemoglobin level greater than 2% at screening or baseline by pulse co-oximeter. * subjects with a previous history of methemoglobinemia * subjects being treated with nitrates or any drug associated with methemoglobinemia * subjects with a known history of hiv, hepatitis, or other blood-borne pathogens.

Keywords: acne
supportive care intervention-pancreas

Conditions: Advanced Pancreatic Cancer

Summary: this is a pilot, randomized controlled trial of an embedded collaborative model of supportive care designed to improve quality of life and decrease use of unwanted healthcare services at the end of life for patients with advanced pancreatic cancer. we will enroll 30 patients who are receiving treatment at the hillman cancer center for recently diagnosed, locally advanced or metastatic pancreatic adenocarcinoma, as well as their accompanying caregivers and providers. patients will be randomized to receive either the supportive care intervention or usual care. the purpose of this study is to refine an embedded collaborative model of supportive care and to develop protocols for recruitment, randomization, and longitudinal data collection.


Eligibility criteria:
inclusion criteria: * patients: * adults (≥ 18 years old) * pathologically-confirmed locally advanced or metastatic pancreatic adenocarcinoma diagnosed within the past 8 weeks * eastern cooperative oncology group (ecog) performance status of 0 (asymptomatic), 1 (symptomatic but fully ambulatory), or 2 (symptomatic and in bed \<50% of the day) * planning to receive continued care from an oncologist at the hillman cancer center * accompanied by a caregiver (family member or friend) at the first visit * caregivers: * adults (\>= 18 years old) * family member or friend of an eligible patient exclusion criteria: * patients: * unable to read and respond to questions in english * not planning to receive continued care from an oncologist at the hillman cancer center * pancreatic neuroendocrine cancer * caregivers: * unable to read and respond to questions in english

Keywords: supportive care palliative care pancreatic cancer embedded, coordinated model of supportive care within oncology care patient and caregiver support
postmarketing surveillance study of anticholinergics - prescribing pattern and therapeutic long term value in patients suffering from moderate or severe chronic obstructive pulmonary disease (copd)

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: to obtain further information on the prescribing pattern and therapeutic long term value in patients suffering from moderate or severs chronic obstructive pulmonary disease under conditions of daily practice


Eligibility criteria:
inclusion criteria: * patients of both genders older than 40 years, who suffer from moderate or severe chronic obstructive pulmonary disease * only patients who showed following diagnosis parameters were to be considered for inclusion * fev1 (forced expiratory volume in 1 second) and fev1/vc (vital capacity) \<70% * reversibility fev1 \<12% in the last 6 months * smoker or ex-smoker (\>10 pack years) * asthma to be excluded exclusion criteria: • contraindications listed in the instructions for use/summary of product characteristics
intravenous anesthesia versus anesthesia with volatile agents in elective craniotomy for tumors

Conditions: Brain Neoplasms

Summary: if the anesthetic regimen can influence the serum level of inflammatory cytokines and if the levels of cytokines are related to the incidence of post operative complications, these complications may be a function of the anesthetic method. in an effort to find the best anesthetic regimen for patients undergoing craniotomy for intracranial tumors, the researchers will compare the effect of volatile anesthetic with that of total intravenous anesthesia (tiva) on cytokine levels. the researchers will also compare the composite incidence of some common major post-operative complications after craniotomy for intracranial malignancy.

this is a randomized blinded clinical trial. patients will be randomized into one of two groups. one group will receive a volatile anesthetic (sevoflurane)while the other group will receive intravenous anesthetics (propofol + remifentanil) for maintenance of general anesthesia. the anesthesia team will know the result of randomization at induction. postoperative data will be gathered by research personnel who will be blinded to the anesthetic method used. patients will be blinded to the anesthetic they receive until after the 4-week outcomes are collected, when they will have the option to be unblinded. peripheral blood samples will be taken a total of 7 times; pre-induction to anesthesia, 15 minutes after surgical positioning, after the tumor is extracted, and at 6,12,18, and 24 hours after emergence from anesthesia. patients will be called for follow up every week for 4 weeks following discharge.

Eligibility criteria:
inclusion criteria: * patients undergoing general anesthesia for elective surgical excision of a primary brain tumor * age: older than 18 * new and recurrent cases will be included exclusion criteria: * patient refusal * emergency craniotomy * craniotomy after head injuries or intracranial bleeding * patients with active inflammatory processes such as infection or immunologic illnesses known to increase baseline immunologic markers * preoperative diagnosis of dvt by lower extremity ultrasound or symptoms * preoperative pulmonary infiltrative disease (pulmonary fibrosis, sarcoid, etc.) * pregnancy

Keywords: intracranial tumors inflammatory markers craniotomy postoperative complications
vaginal self-sampling and human papillomavirus testing in unscreened women

Conditions: Cancer Cervix

Summary: despite the existence of an effective screening test (pap smear), cervical cancer is, every year in france, the cause of more than 3,000 new cases and 1,100 deaths. but, in france, 4 in 10 women are not screened or not often enough (nearly 7 millions women). it is therefore necessary to develop new strategies to reach these women. the etiological factor of this cancer is persistent infection with high-risk human papillomavirus oncogene (hr-hpv). thereby, hpv-based tests could be alternative screening tests. vaginal self-sampling with hr-hpv test is simpler and less intrusive than the pap smear. it has been shown that vaginal self-sampling with hpv test is a powerful means to increase the participation rate in cervical cancer screening.


Eligibility criteria:
inclusion criteria: * women from 30 to 65 years old * women living in french territorial division 37 ("indre-et-loire") * women having a reported general practitioner in french territorial division 37 ("indre-et-loire") exclusion criteria: * pap smear made in the three last years

Keywords: cervical cancer screening high risk human papillomavirus infection vaginal self-sampling pap smear general practitioner
zygomatic versus conventional dental implants in augmented maxillae

Conditions: Edentulous Maxilla; Resorbed Maxilla; Implant Therapy

Summary: dental implants are used for replacing missing teeth. placing dental implants is limited by the presence of adequate bone volume permitting their anchorage. in order to solve this problem several bone augmentation procedures have been developed. in principle the missing bone is taken from a donor site (for example the hip), transplanted where needed and then implants are placed. sometimes, major bone grafting operations have to be undertaken under general anaesthesia requiring patients to be hospitalised for a few days. some degree of morbidity related to the donor site must be expected, though more recently bone substitutes are used to minimize morbidity, and 2 to 3 surgical interventions may be needed before the implants can be functionally used. sometimes patients have to wait more than 1 year before a prosthesis can be fixed to the implants and the total cost of the treatment is high. at the beginning of the 1990s a long screwshaped implant was developed by professor pi brånemark as an alternative to bone augmentation procedures: the zygomatic implant. zygomatic implants are generally inserted through the palate to engage the body of the cheek bone. one to three zygomatic implants can be inserted through the posterior palate to engage the body of each cheek bone. the potential main advantages of zygomatic implants could be that bone grafting may not be needed and a fixed prosthesis could be fitted the same day of their placement. despite that zygomatic implants have been used for more than 20 years, their effectiveness has never been compared with conventional dental implants in augmented maxillae. the aim of the project is to compare the longtermclinical outcome of fullarch upper jaw bridges supported by zygomatic implants versus conventional implants placed in augmented bone in the palate.


Eligibility criteria:
inclusion criteria: * fully edentulous patients * atrophic maxilla * insufficient bone volume for placement of dental implants * patients with no more than 4mm of bone height sub-antrally exclusion criteria: * general contraindications to implant surgery * history of radiation therapy * immunosuppressed/immunocompromised patients * patients taking bisphosphonates * poor oral hygiene * patients with untreated periodontitis * uncontrolled diabetes * pregnancy * alcohol/drug addiction * lack of opposite occluding dentition/prosthesis * restricted mouth opening.