Kornimate/medical-research-clean huggingface dataset:
capsaicin effect on cytokines profile in dyslipidemia

Conditions: Dyslipidemia; Overweight or Obesity

Summary: the increased mortality from cardiovascular disease has a significant impact on the population, and the prevalence of these diseases it become one of the major problems, since it is the leading cause of mortality and 1 in 3 mexicans suffer from cardiovascular disease according ensanut; the above is attributed to the increase of diseases associated with an inflammatory process accelerated as obesity, dyslipidemia, hypertension (sah) and diabetes mellitus (dm). the cholesterol is a major risk factor in the development of cardiovascular disease, and in turn increases the chances of death; however, the treatment of choice is based on changes in lifestyle, which for most people are difficult to maintain long-term. as for the drug therapy treated with drugs many people do not achieve their therapeutic goals, and therefore the inflammatory condition that underlies this disease remains. recent studies have focused on the possible role of capsaicin in the inflammatory state through the agonistic effect it has on trpv1. it has demonstrated the antiinflammatory activity of capsaicin to enhance inflammation by free fatty acids (ffa) and reducing the expression of certain genes involved in this process induced. capsaicin is a natural choice and well tolerated with few side effects limited to the gastrointestinal tract such as dyspepsia and intestinal irregularity, for the above is of interest to evaluate the effect of capsaicin on the profile of inflammatory cytokines in individuals with dyslipidemia.

it will conduct a clinicala trial, double - blind, randomized and placebo control group. female and male patients, with dyslipidemia. two groups will be formed with 17 patients each (capsaicin 150 mg per day or magnesia calcinada). at the beginning and end of the intervention clinical and laboratory determination. the data obteined were analyzed using spss statistical software version 22. it was considered statistically significant at p \<0.05

Eligibility criteria:
inclusion criteria: * diagnosis of dyslipidemia at the time of screening * bmi of 25 kg /m2 to 34.9 kg / m2 * without drug treatment in the last three months * signature of consent information in writing exclusion criteria: * pregnant or lactating * total cholesterol ≥ 239 mg / dl, ≥400 tg, ldl-c ≥139 * other inflammatory diseases * consumption of some type of supplement * diagnosis or history of kidney or liver disease ∞ history of hypersensitivity to the compounds used in the study

Keywords: capsaicin dyslipidemia inflammatory cytokines
effectiveness of the quotient® adhd assessment in a system of care

Conditions: Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder With Hyperactivity

Summary: the study goal is to examine whether the use of an objective computerized neuroassessment (the quotient system) for attention-deficit/hyperactivity disorder (adhd) is related to improved outcomes among pediatric patients being assessed and treated for adhd.

this study is a randomized, controlled trial using a 2-phase data collection. the first phase is the initial assessment for adhd and includes all patients eligible to be assessed for adhd as determined by their clinician in the course of usual care. the baseline measurements will be used to compare groups at baseline, and also for longitudinal analyses of medication management. patients are randomized at this point. patients in both treatment arms who then receive an adhd diagnosis and who start medication for adhd will be eligible for the second phase of the study: three follow-up assessments over six months. patients who do not have an adhd diagnosis will not continue in the study, and will be treated by their clinician as usual.

Eligibility criteria:
inclusion criteria: * all patients within the specified age range who are english speaking and who are presenting for adhd assessment are eligible. an additional criterion is consent to be randomized. exclusion criteria: * non english speaking * refusal to participate

Keywords: attention deficit and disruptive behavior disorders attention deficit disorder with hyperactivity pediatrics patient outcome assessment
corevalve® system australia/new zealand clinical study

Conditions: Aortic Valve Stenosis

Summary: to evaluate the performance, efficacy and safety of the percutaneous implantation of the corevalve® prosthetic aortic valve in patients with severe symptomatic native aortic valve stenosis that have an elevated surgical risk

prospective, non-randomized, single-arm multi-center trial conducted under a common protocol at 10 centers in australia and new zealand.

Eligibility criteria:
inclusion criteria 1. documented severe aortic valve stenosis 2. access vessel diameter \>6 mm as defined pre procedure via angiographic measure 3. aortic valve annulus diameter ≥ 20 mm and \< 29 mm as defined pre procedure by echocardiographic measure 4. ascending aorta diameter ≤ 43 mm at the sino-tubular junction 5. native aortic valve disease, defined as valve stenosis with an aortic valve area\<1cm2 (\<0.6cm2 /m2) as defined pre procedure by echocardiographic measure and (assessment of surgical risk) age ≥ 80 years and/or surgical risk calculated with logistic euroscore ≥ 20%, and/or age ≥ 65 years with one or two (but not more than 2) of the following criteria: * cirrhosis of the liver (child class a or b) * pulmonary insufficiency : vms \< 1 liter * previous cardiac surgery (cabg, valvular surgery) * porcelain aorta * pulmonary hypertension \> 60 mmhg and high probability of cardiac surgery for other than valve replacement * recurrent pulmonary embolus * right ventricular insufficiency * thoracic burning sequelae contraindicating open chest surgery * history of mediastinum radiotherapy * severe connective tissue disease resulting in a contraindication to surgery * cachexia (clinical impression) 6. study subjects must be willing and able to attend all follow-up visits within specified visit windows, and agree to undergo all protocol evaluations at each visit exclusion criteria: 1. known hypersensitivity or contraindication to aspirin, heparin, ticlopidine, clopidogrel, nitinol, porcine products, or contrast media which cannot be adequately pre-medicated 2. any sepsis, including active endocarditis. 3. recent myocardial infarction (\<30 days) 4. any left ventricular or atrial thrombus as determined pre procedure by echocardiography 5. uncontrolled atrial fibrillation 6. mitral or tricuspid valvular insufficiency (\> grade ii) 7. previous aortic valve replacement (mechanical valve or stented bioprosthetic valve) 8. evolutive or recent cva (cerebrovascular accident), (\<3 months) 9. femoral, iliac or aortic vascular condition (e.g. stenosis, tortuosity), that make impossible insertion and endovascular access to the aortic valve 10. symptomatic carotid or vertebral arteries narrowing (\> 70%) disease 11. abdominal or thoracic aortic aneurysm 12. bleeding diathesis or coagulopathy, or patient will refuse blood transfusion 13. evolutive disease with life expectancy less than one year 14. creatinine clearance \< 20 ml/min 15. active gastritis or known peptic ulcer disease 16. pregnancy

Keywords: aortic valve stenosis aortic valve insufficiency
do more, b'more, live fit

Conditions: Cystic Fibrosis; Physical Activity

Summary: physical activity (pa) in individuals with cystic fibrosis (cf) improves exercise capacity, slows decline in lung function, increases mucus clearance and improves health-related quality of life (hrqol). establishing and maintaining an exercise routine remains challenging and programs promoting pa in people with cf have poor participation. moreover, while the positive effects of physical conditioning on lung function have been well reported, conventional measurements of lung function may lack the sensitivity to reveal improvement in mild lung disease. this randomized control trial (rct; n = 60) evaluates the do more, b'more, live fit, a 6-month fitness program designed to optimize exercise habits of 12-21 year-olds with cf through structured exercises with personalized coaching, exercise equipment including the fitbit flex, online support and motivational messages delivered electronically. the intervention incorporates fitness preferences and encompasses endurance, strength and flexibility exercises while adjusting to physical fitness needs. the hypothesis is that intervention participants will have increased and sustained engagement and better health outcomes compared to control group participants. the investigators' specific aims are to: 1. increase daily pa and measures of fitness 2. improve lung clearance index (lci) and participant hrqol 3. demonstrate feasibility, accessibility and satisfaction of intervention using semi-structured interviews the results of this pilot evaluation of the do more, b'more, live fit program will offer novel insight into factors that sustain engagement in exercise programs and identify if lci is an appropriate clinical outcome to assess pa interventions. results will inform future rct of interventions to optimize exercise habits of adolescents with cf.


Eligibility criteria:
inclusion criteria: * 12-21 year-old patients with a diagnosis of cystic fibrosis that are cared for at johns hopkins * participants must have smart phone and/or computer with universal serial bus (usb) access to set-up fitbit flex exclusion criteria: * forced expiratory volume in 1 second (fev1) \< 40% predicted * individuals already participating in vigorous physical activity as assessed by the study team such as participating in year-round organized sports and/or aerobic exercise \>30 minutes more than 5 times/week may or may not be included in this study at the discretion of the pi and study team.
different intensities of continuous aerobic exercises in cardiac rehab phase 2

Conditions: Heart Diseases

Summary: to determine the effects of different intensities of continuous aerobic exercises on fatigue levels, mental well- being \& mindfulness in cardiac rehab phase 2.

physical activity has a strong association with health outcomes as it enhances physical and mental function by maximising cardio respiratory fitness and reduces the risk of multiple chronic diseases. aerobic exercise is the type of physical activity that accelerates and maintain fitness, well being and quality of life of human being. aerobic means in presence of oxygen and is based on the power generating process by the utilization of oxygen as a major fuel to cope up the energy demands during sustained physical activity. during aerobic exercise lungs get more efficient by enhancing their breathing capacity which leads to the removal of carbon dioxide and maximal utilization of oxygen and improvement of its transport to lungs and muscles by circulating blood. aerobic is the form of exercise which helps in oxygen transportation and absorption while enhancing the efficiency of cardiovascular system. long term aerobic exercises significantly affect the structure of heart and improve stroke volume of heart. fatigue is a feeling of tiredness and leads towards the inability of muscles to perform physically. it is mostly complained during cardiovascular disease and affects the functioning and quality of life in cardiac patients. mental well-being is an important constituent of health. good mental health proves to be beneficial for patients' recovery and independency in activities of daily living. chronic diseases have a very strong association with mental disorder. mindfulness is the ability to be fully alert and mental presence in the moment. physical training boosts the mindfulness by enhancing the functioning of anterior cingulate cortex that has been linked to the improvement of self-regulation and attention. aerobic exercises can improve the mood mindfulness.

Eligibility criteria:
inclusion criteria: * new york heart association (nyha) (class 1, class ii) * class i - no symptoms and no limitation in ordinary physical activity, e.g. shortness of breath when walking, climbing stairs etc. * class ii - mild symptoms (mild shortness of breath and/or angina) and slight limitation during ordinary activity. * post coronary artery bypass grafting (cabg) * patients diagnosed with mild to moderate depression on basis of patient health questionnaire (phq-9) exclusion criteria: * recurrent myocardial ischemia or infarction (mi) * unstable angina * any diagnosed psychological disease * patients with impaired cognition function * patients with severe life-limiting illness such as cancer, and renal failure. * congestive heart failure
arimidex: compliance and arthralgias in clinical therapy (compact)

Conditions: Breast Cancer

Summary: patients are eligible for inclusion in this nis if they have taken anastrozole either upfront or following two to three years of tamoxifen treatment ("switch") for at least three and not more than six months prior to offering an individual participation in this program. treatment should follow local therapy guidelines and standard practice. treatment decisions for patients participating in this study including assessments or supportive therapy during follow-up visits will also follow guidelines and remain independent of the program.

the patient population will include postmenopausal women with hormone-receptor positive primary breast cancer scheduled for adjuvant upfront endocrine treatment with anastrozole or following two to three years of tamoxifen treatment ("switch") according to the current smpc (appendix c). patients will have taken anastrozole for at least three months and not more than six months before the start of the study.

Eligibility criteria:
inclusion criteria: * postmenopausal women aged 18 years or older; postmenopause is defined as natural menopause with menses \>1 year ago or serum fsh (\> 20 iu/ l), and e2 levels in the postmenopausal range or patients who had bilateral oophorectomy * histologically / cytologically confirmed primary diagnosis of early breast cancer (m0) with hormone sensitive tumour (er+ve and/or pgr+ve) * patients, who underwent breast cancer surgery and, if appl. radiation therapy and/or neo/adjuvant chemotherapy and have taken adjuvant endocrine treatment with anastrozole (upfront or following two to three years of tamoxifen) min 3 max 6 months * in case of a previous therapy with tamoxifen (switch-therapy), duration of tamoxifen treatment for at least two and up to three years. exclusion criteria: * patients with severe renal function disorders (creatinine clearance \< 20 ml/min or patients with moderate or severe disorders of hepatic function * concomitant treatment with drugs known to affect sex hormonal status and tamoxifen * patients with ductal carcinoma in situ (dcis) without primary diagnosis of early breast cancer (m0) * evidence of any significant clinical disorder or laboratory finding which in the opinion of the investigator, makes it undesirable for the patient to participate in the program

Keywords: primary early mca arimidex
effect of probiotic lozenge on gingivitis and periodontitis

Conditions: Mild and Moderate Chronic Periodontitis

Summary: the oral cavity is mostly influenced by general health. the oral microbiota which is as complex as the gastro-intestinal or vaginal microbiota are considered to be difficult therapeutic targets. the effects of probiotics in different fields of health care have resulted recently in the introduction of probiotics for oral healthcare. probiotics have been clinically proved effective in different fields of oral healthcare such as halitosis, oral candidiasis and tooth decay. they have also been inducted in the field of periodontal healthcare because of the current views on the etiology of plaque- related periodontal inflammation.


Eligibility criteria:
inclusion criteria * patients with chronic mild to moderate periodontitis. * having pocket depth \> 4mm. * mean loss of attachment, evaluated by measuring the distance from cement-enamel junction to the bottom of the probing pocket \> 4mm exclusion criteria: * patients on probiotic supplements * patients who have allergy to lactose and fermented milk products * smokers * patients who are on antibiotic therapy or were on antibiotic therapy in the past 6 months * patients with advanced periodontal and/or periapical conditions which necessitate immediate treatment * patient suffering from any systemic illness * patients who are deemed to be un-cooperative
swedish spinal stenosis study

Conditions: Lumbar Spinal Stenosis

Summary: a national randomized multicentre trial (rct) where decompression is compared with decompression with simultaneous fusion in 245 patients with spinal stenosis on one or two adjacent lumbar levels with or without degenerative olisthesis. the material is stratified for the existence of degenerative olisthesis \>3mm. monitoring is performed with clinical results from patient surveys after 2 and five years, and with radiological follow-up (mri, ct and plain x-ray) and an objective function test (6 min walking test) after 2 years. the null hypothesis is that there is no difference in results between the two interventions.


Eligibility criteria:
inclusion criteria: * pseudoclaudication in one or both legs and backpain (vas\>30) * mri with 1-2 adjacent stenotic segments (area \<0.75 mm2)between l2 and sacrum * duration of symptoms \>6 months * informed consent exclusion criteria: * spondylolysis * degenerative lumbar scoliosis (cobb angle \>20 deg) * history of lumbar spinal surgery for spinal stenosis or instability * stenosis not caused by degenerative changes * stenosis caused by herniated disc * other specific spinal conditions, mb bechterew, malignancy, neurologic disorders * history of vertebral compression fractures in affected segments * psychological disorders where the surgeon considers participation inappropriate(dementia, drug abuse)

Keywords: spinal stenosis decompression fusion olisthesis
all-on-4® treatment concept

Conditions: Edentulous

Summary: indication : edentulous patients to evaluate and compare the marginal bone level change around tilted and straight nobelactive implants placed in healed sites with all-on-4-treatment concept after immediate function supporting nobelprocera implant bridge (fixed) in the mandible and maxilla.


Eligibility criteria:
the subject is at least 18 years of age (or age of consent) and has passed secession of growth obtained informed consent from the subject edentulous mandible or maxilla providing sufficient bone whereas a fixed nobelproceratm implant bridge on four (4) implants is regarded as an appropriate treatment solution the subject has an osseous architecture enough to receive four implants and a sufficient amount of bone for placing in healed sites implants with a length of at least 8 mm the implant site is free from infection and extraction remnants implants will be placed in healed sites. good gingival / periodontal / peri-apical status of opposing teeth/implants the subject fulfills the prerequisite that a harmonic, stable occlusal relationship can be achieved with opposing natural teeth resp. fixed or removable opposing dentition (tooth or implant based the subjects as well as the implant site(s) fulfill the criteria for immediate loading. the subject is in such a physical and mental condition that a 5-year follow-up period can be carried out without foreseeable problems the subject is available for the 5-year term of the investigation exclusion criteria: the subject is not able to give her/his informed consent of participating health conditions, which do not permit the surgical (including anesthesia) or restorative procedure reason to believe that the treatment might have a negative effect on the subject's overall situation (psychiatric problems), as noted in subject records or in subject history any disorders in the planned implant area such as previous tumors, chronic bone disease or previous irradiation in the head/neck area alcohol or drug abuse as noted in subject records or in subject history smoking of \>10 cigarettes/day uncontrolled diabetes, i.e. a subject with diagnosed diabetes that has a history of neglecting doctor's recommendations regarding treatment, food and alcohol intake pathologic occlusion, e.g. severe bruxism or other destructive habits lack of opposing dentition or unstable occlusion ongoing infections, endodontic or periodontal problems in opposing teeth or implants subject shows an unacceptable oral hygiene subject has allergic or adverse reactions to the restorative material. bone augmentation of more than 3mm vertical height performed less than 6 months prior to planned implant placement. bis-phosphonate therapy implant insertion torque is \ 70 ncm

Keywords: edentulous nobel active nobel procera ibo cad/cam
high school start time and teen migraine frequency

Conditions: Migraine

Summary: migraine is common in adolescents and can cause missed school and disability. the american academy of pediatrics (aap) recommends that high schools start no earlier than 8:30 am in order to accommodate the physiologic needs of adolescents-whose brains naturally want to fall asleep later and wake up later and who still need to get at least 8 hours of sleep per night to function optimally-however, only about 18% of us high schools comply with this aap recommendation. there is a relationship between adequate sleep and migraine. the investigators aim to determine whether high school students with migraine who attend high schools that comply with this aap recommendation have lower migraine frequency than those that do not. if so, it would argue for advocating for changes in high school policy to optimize health of adolescents with migraine.

study design: this is an observational study of high-school students in the u.s. who have migraine and who attend a standard high school (i.e. are not home schooled or online schooled). they will complete a one-time online survey answering questions about their headaches and their schedule--particularly schedule aspects related to school and sleep.

Eligibility criteria:
inclusion criteria: 1. live in the u.s. 2. in 9th-12th grade 3. attends a high school that is outside of the home (i.e. not home-schooled or online schooled) 4. high school has a consistent start time all 5 days of the week 5. has migraine by international classification of headache disorders criteria 6. can read and write in english exclusion criteria: na