the physical activity and nutrition in children (panic) study

Conditions: Overweight; Glucose Metabolism Disorders; Lipid Metabolism Disorders; Blood Pressure; Atherosclerosis

Summary: the physical activity and nutrition in children (panic) study is a single-centre controlled trial on the effects of a combined physical activity and dietary intervention on cardiometabolic risk factors and other health outcomes in a population sample of children from the city of kuopio, finland. the study provides novel scientific information for the identification of cardiometabolic diseases and other chronic diseases since fetal period and for the prevention of these chronic diseases since childhood. the main hypothesis of the panic study is that individuals at increased risk of cardiometabolic diseases and other chronic diseases can be identified in childhood and that it is possible to start the prevention of these chronic diseases by a long-term physical activity and dietary intervention since childhood.

we will investigate a population sample of 512 children from the city of kuopio, finland. the children will be recruited in 2007-2009 when they are 7-9 years of age and when they will start the first grade in primary schools of the city of kuopio. the children will be allocated to the combined physical activity and dietary intervention group and the control group after baseline examinations carried out in 2007-2009. the intervention group will undergo individualized and family-based physical activity and dietary intervention, including six intervention visits, for two years. all children from the intervention and control group will be invited to 2-year follow-up examinations carried out in 2009-2011 when they are 9-11 years of age. the intervention group will continue with a less intensive physical activity and dietary intervention until 8-year follow-up examinations carried out in 2015-2017 when the participants are 15-17 years of age. the participants from the intervention and control group will continue with an open follow-up until 14-year follow-up examinations in 2021-2023 when they are 21-23 years of age. all of these study phases will include comprehensive and detailed assessments of behavioral, biological, environmental, and genetic risk factors for cardiometabolic diseases and other chronic diseases. the results of the panic study will help in 1) decreasing the risk of developing cardiometabolic diseases and other chronic diseases since childhood by increasing physical activity, decreasing sedentary time, and improving diet, 2) identifying children and adolescents at increased risk of cardiometabolic diseases and other chronic diseases who would benefit most from the physical activity and dietary interventions, 3) targeting children and adolescents, particularly those at increased risk of cardiometabolic diseases and other chronic diseases, for more careful health examinations, physical activity and dietary interventions, and health follow-up, and 4) preventing cardiometabolic diseases and other chronic diseases as well as their societal consequences in adulthood.

Eligibility criteria:
inclusion criteria: * boys and girls, 6-9 years of age at baseline, from the city of kuopio, finland exclusion criteria: * physical disabilities that could hamper participation in the intervention * no time or motivation to attend the study

Keywords: children adolescents physical activity sedentary time nutrition diet body composition overweight obesity insulin glucose lipids adipokines myokines metabolomics fitness arterial elasticity atherosclerosis blood pressure bone mineral density genetics gene-lifestyle interaction oral health oral bacteriomics wellbeing depression sleep pain health economics healthcare services medication cost-effectiveness