Kornimate/medical-research-clean huggingface dataset:
pilot study of behavioural intervention for nutrition in cystic fibrosis

Conditions: Cystic Fibrosis

Summary: cystic fibrosis (cf) is a lifelong condition which causes the lungs and digestive system to become clogged with thick, sticky mucus. this leads to recurrent lung infections and reduced nutrients absorption from food. the average age at death is 26 years, usually from respiratory failure. nonetheless, the nutritional status of people with cf (pwcf) is important help them live healthier and longer. it is recommended that adult with cf achieve a bmi of 23 for males and 22 for females. however, fewer than 50% adult with cf achieved that target bmi despite effective nutritional support to help support weight gain. there is a clear need for a behavioural intervention that can help pwcf use the available nutritional support. this is a feasibility study to try out a multi-component behavioural intervention. the intervention is designed to help pwcf use their nutritional support to gain weight. it will focus on testing the methods and procedures to be used on a larger scale, improving the behavioural intervention and estimating the how many people are needed for the larger trial. all eligible 75 pwcf in sheffield will be invited to participate. the investigators anticipate recruiting 30 participants. participants will be divided into two groups. the first group receive the behavioural intervention immediately. the second group receive the intervention after 3 months. all participants will be followed up for 6 months. data will be collected every 6 weeks during clinic reviews. these two groups will be compared against each other to estimate the potential impact of the behavioural intervention. the investigators will also interview some of the participants at the end of the study period to improve the intervention and the study processes based on participant feedback. the investigators hypothesised that this study will recruit around 30 participants, around 80% of the participants will complete the study, a single full-time investigator can deliver the intervention to 15 participants over 3 months and data collection will be thorough (with less than 5% missing data). the investigators also hypothesised that this feasibility study will help improve the intervention and help the design of a larger trial.


Eligibility criteria:
inclusion criteria: * adult people with cf looked after at the sheffield adult cf unit * best bmi of \< 23 for males and \< 22 for females between oct '12 and oct '13 exclusion criteria: * patients in the palliative phase of disease * patients who are pregnant * patients who have no capacity to consent to participate in the study * patients who have no it facilities to use the web-based food diary * patients who are unable to communicate by telephone for coaching

Keywords: cystic fibrosis nutrition weight bmi behaviour change
fatigue and cognitive demand with aging

Conditions: Fatigue

Summary: this study will determine the influence of a cognitive task performed during fatiguing contractions.

individuals will participate in one familiarization session followed by 3 randomized experimental sessions (crossover design).

Eligibility criteria:
inclusion criteria: * healthy individuals aged between 18-35 and 65-90 exclusion criteria: * metal implants or joint replacement. neuromuscular disease

Keywords: sex difference aging
continuous infusion for pain relief

Conditions: Regional Anesthesia; Caeserian Section; Local Anesthetic

Summary: spinal anesthesia is commonly used for cesarean section, and it has become a popular practice to add opioids to spinal solutions to enhance and prolong intraoperative and postoperative analgesia. high incidence of side effects was noted. is there any alternative?


Eligibility criteria:
inclusion criteria: * asa physical status i-ii * 18-45 years of age, inclusive * elective caeserean section under spinal anesthesia exclusion criteria: * - contraindications to spinal anesthesia (e.g., allergy to local anesthetics, coagulopathy, malignancy or infection in the area) * existing neurological deficit * inability to understand the informed consent and demands of the study
partial caries removal in permanent molars restored using giomer

Conditions: Caries, Dental

Summary: dental manufacturers\&#39; constant tweaks and improvements to composite compositions have resulted in a wider spectrum of restorative materials with positive long-term clinical performance. for example, the creation of bioactive giomer material with proven continuous multi-ion release has been beneficial in avoiding demineralization and imparting acid resistance to enamel and dentin.

giomer resin not only reduces the risk of secondary caries around restorations by releasing fluoride ions, but it also has good esthetic, physical, and handling features. furthermore, advancements have been made to reduce giomer resin polymerization shrinkage by incorporating filler technology into the matrix system. as a result of these efforts, giomer resin is currently distinguished by its low shrinkage feature. according to the manufacturer, low shrinkage giomer resin has volumetric shrinkage of 0.8% and a polymerization shrinkage stress of 2.72 mpa. several investigations were carried out to examine the overall clinical performance of low shrinkage giomer resin with equivalent success rates when compared to other restorative materials. the aim of the current study is to evaluate the effect of giomer in maintaining pulp health and dentin bridge formation after partial caries removal in permanent teeth with deep occlusal carious lesion when compared to resin composite restoration.

Eligibility criteria:
inclusion criteria: 1. inclusion criteria of participants: * 18 -35 years. * not received antibiotic therapy since 1 month before sampling. * males or females (both genders). * co-operative patients approving the trial. * good to fair oral hygiene 2. inclusion criteria of teeth: * class i cavitated lesions in permanent molars (reaching \&gt;1/2 of the dentin on radiographic examination) * absence of spontaneous pain; negative sensitivity to percussion; and absence of periapical lesions (radiographic examination). exclusion criteria: 1. exclusion criteria of participants: * known allergic reaction to resinous materials. * systemic disease or severe medical complications. * periodontal problem. * bruxism * poor oral hygiene 2. exclusion criteria of teeth: * class ii caries lesion * shallow or enamel caries * teeth with periapical lesions. * mobile teeth, arrest caries and non-vital teeth

Keywords: partial caries removal bioactive giomer
evaluation of the corneal endothelial cell layer by specular microscopy in patients with thyroid eye disease

Conditions: Thyroid Eye Disease

Summary: to investigate corneal endothelial cell layer damage by specular microscopy in patients with thyroid eye disease

thyroid eye disease is a common periorbital autoimmune inflammatory disease .it significantly impairs quality of the life ,causes cosmetic defects ,and could be sight-threatening ,especially when optic nerve or the cornea is affected.classic manifestations of thyroid eye disease include proptosis ,lid retraction ,lagophthalmos,optic neuropathy and restrictive extraocular myopathy.in addition to the affection of the orbital and lacrimal glands ,the corneal endothelium has showen morphological changes in patients with thyroid eye disease .corneal endothelium is the innermost corneal layer facing the anterior chamber and is known for maintaining corneal transparency by its pump-leak function .corneal transparency is crucial for optimal vision . severe damage to corneal endothelium can induce corneal opacification .resulting in corneal edema and subsequently vision loss. that is because there are thyroxine receptors in all layers of the conea. and the autoantibodies to tsh receptors usually attach to them causing damage to the cornea.specular microscopy is one of the best investigative procedure used to assess changes in the corneal endothelium due to thyroid eye disease.specular microscopy is a noninvasive photographic technique that analyze the corneal endothelium. using computer-assisted morphometry, modern specular microscopes analyze the characteristics of the endothelial cells. the instrument projects light onto the cornea and captures the image that is reflected from the optical interface between the corneal endothelium and the aqueous humor. the reflected image is analyzed by the instrument and displayed as a specular photomicrograph

Eligibility criteria:
inclusion criteria: * patients with thyroid eye disease whom diagnosis was established based on bartley diagnostic criteria . exclusion criteria: * participates with systemic diseases other than ht such as 1. diabetes mellitus 2. previous ocular surgery or laser therapy. 3. history of corneal disease. 4. history of trauma. 5. history of glaucoma
pain sensitivity questionnaire and postoperative opioid requirement

Conditions: Postoperative Pain

Summary: this study aims to investigate the potential association between pain sensitivity questionnaire score, the severity of postoperative pain, and postoperative analgesic requirement in patients with open colorectal cancer surgery. this information may be used to guide the optimal postoperative pain management, and ultimately improve patient's quality of life.

we plan to investigate the predictive ability of the psq as well as experimental parameters of pain sensitivity using electronic algometer and other known risk factors for postoperative pain in 100 patients scheduled for open colorectal cancer surgery. the following items are investigated before surgery; age, sex, level of education, type of surgery, past surgical history, presence of chronic pain, the expected maximal pain score (vas) after surgery, pain catastrophizing scale, anxiety scale (hads-a), pain sensitivity questionnaire, and pain threshold measured by electronic algometer. the total opioid consumption is investigated for 24 and 48 hours after surgery. in addition, the severity of postoperative pain is measured by the 11-point vas at 24 and 48 hours after surgery. patient satisfaction with postoperative pain control is also investigated at 48 hours after surgery using the 7-point patient's satisfaction scale.

Eligibility criteria:
inclusion criteria: * age 18 years or above * patients scheduled for open colorectal cancer surgery under general anesthesia * asa status i-iii * ability to read and understand the information sheet, questionnaires, and the - consent form * patients scheduled for using iv-pca after surgery exclusion criteria: * unable to read and understand the information sheet, questionnaires, and the consent form * severe medical or psychological diseases * patients with preoperative chronic pain

Keywords: postoperative pain pain sensitivity
post-operative drainage following lymph node dissection

Conditions: Malignant Melanoma; Carcinoma, Squamous Cell

Summary: the purpose of this study is to determine whether the use of fibrin sealant reduces post-operative drainage following groin and axillary lymph node dissection.

background: fibrin sealant has been used for many years in clinical practice and has a wide range of applications including the control of lymphatic leaks and haemostasis. the physiological mechanism of action of fibrin was first described by morawitz in 1905; fibrin sealant was first marketed in 1983. lymph node dissection is undertaken for the control of malignant disease - frequently malignant melanoma or squamous cell carcinoma. following groin or axillary dissection, excessive post operative drainage may necessitate the presence of wound drains for 10 days or more. this may prolong hospital stay in some patients, and may be associated with an increased complication rate (such as wound infection). hypothesis: the use of fibrin sealant prior to wound closure following either groin or axillary dissection may reduce post-operative wound drainage. comparison: patients who require an elective groin or axillary dissection who either undergo standard wound closure or those who have fibrin sealant instilled into the surgical wound prior to wound closure.

Eligibility criteria:
inclusion criteria: * patients over 18 years of age * requiring groin or axillary lymph node dissection for malignant disease. exclusion criteria: * patients under age 18 years. * patients unable to speak english. * patients with learning difficulties. * patients with mental illness. * prisoners. * other vulnerable groups.

Keywords: groin dissection axilla (or axillary) dissection lymph node dissection lymphadenectomy seroma wound drainage fibrin sealant malignant melanoma squamous cell carcinoma
rapid maxillary expansion and protraction by expander differential opening edo in cleft lip and palate patients

Conditions: Cleft Lip and Palate

Summary: maxillary expansion in cleft palate patient with expander and using face mask.

patient with cleft palate and maxillary constriction, deficiency will be treat using expander with differential opening which has two screws on anteriorly and another posteriorly positional in midline palate anteriorly as much as possible. rapid maxillary expansion will be using one turns in day(two turns in the morning and two turns in the evening). with petit face mask for maxillary protraction and superimposition cbct will be taken between before and after treatment .

Eligibility criteria:
inclusion criteria: * ● patients of both sexes. * cleft lip and palate patients. * all patient age range 8-12 years. * all the case showed maxillary arch constriction and deficiency. * all patients had maxillary permanent first molars. * primary lip adhesion and palatal closure. exclusion criteria: * • absent maxillary permanent first molars. * patients had received any surgical assisted rapid maxillary expansion, maxillary protraction or fixed orthodontics before. * less than two dental unit beside maxillary first molar. * uncooperative patients/parents.

Keywords: cleft palate patient rapid maxillary expansion rme cone beam computed tomography cbct expansion face mask
the effect of methods of self-regulation of mental state on pain perception in the postoperative period in colon cancer patients

Conditions: Colonic Neoplasms; Pain, Postoperative; Hypnotherapy

Summary: in this study, it will be investigated whether the methods of self-regulation of mental state have an effect on postoperative pain perception in colon cancer patients.

according to the assumptions of psychoneuroimmunology, the improvement of mental state affects the physical improvement of patients. numerous studies confirm the effectiveness of hypnosis and learning autohypnosis in improving the functioning of patients in terms of reducing pain and anxiety, improving the quality of sleep and mood. the study is a prospective randomized controlled trial consisting of two groups. patients in the study group will receive a voice recording with hypnotic instructions with a suggestion to improve the psychophysical state. patients in the control group will receive a recording with relaxing music. depending on the randomization, patients will listen to the selected recording before being admitted to the surgical department. they will then be given a recording to listen to whenever they want. the patients will be examined four times using the activity change scale, ie. before randomization, on the first day after surgery, on the 7th day after surgery and 1 month after surgery. simultaneously the total analgesic consumption will be recorded.

Eligibility criteria:
inclusion criteria: 1. written informed consent to participate in the study 2. age \>= 18 years 3. histopathological diagnosis of primary colon cancer without distant metastasis 4. planned surgical treatment 5. fluency in polish exclusion criteria: 1. severe comorbidities with pain disorders 2. regular use of analgesics 3. coexistence of another neoplastic disease 4. use of non-pharmacological pain management (including autohypnosis) prior to the study 5. poor general condition 6. previous colorectal surgery 7. hearing disorders 8. no possibility of playback of the received recording

Keywords: colonic neoplasms colorectal neoplasms colectomy colorectal surgery pain, postoperative analgesics hypnosis autosuggestion mind-body therapies hypnotherapy psychotherapy
dexmedetomidine facilitate analgesia

Conditions: Lower Limb Fracture; Nerve Block

Summary: pre-clinic evidences showed that dex produces antinociception by inhibiting the activation of spinal microglia and astrocyte decreasing noxious stimuli evoked release of nociceptive substances and further interrupting the spinal neuron-glia cross talk and regulating the nociceptive transmission under chronic pain condition. in this study, the analgesic efficacy of dexmedetomidine was evaluated by a new non-invasive nociceptive index (qnox). in this study, anagel6000 analgesia monitor was used to quantitatively compare the analgesic efficacy of dexmedetomidine compared with midazolam.

pre-clinic evidences showed that dex produces antinociception by inhibiting the activation of spinal microglia and astrocyte decreasing noxious stimuli evoked release of nociceptive substances and further interrupting the spinal neuron-glia cross talk and regulating the nociceptive transmission under chronic pain condition. in this study, the analgesic efficacy of dexmedetomidine was evaluated by a new non-invasive nociceptive index (qnox). in this study, anagel6000 analgesia monitor was used to quantitatively compare the analgesic efficacy of dexmedetomidine compared with midazolam.

Eligibility criteria:
inclusion criteria: * aged from 18 to 80 years old * american association of anesthesiologists (asa) grade ⅱ \~ iv * body mass index (bmi) 18.5-40 * planning undergoing peripheral nerve block exclusion criteria: * incomplete effect of nerve block * alzheimer's disease * implanted cardiac pacemakers * mental illness * epilepsy * autonomic nervous system diseases * projected the duration of the operation was more than 3 hours

Keywords: dexmedetomidine nociceptive index
development of exercise training programme for older people with musculoskeletal pain in the community

Conditions: Musculoskeletal Pain

Summary: the rate of musculoskeletal pain among older people is increasing worldwide and significantly impacts the quality of life. regular exercise can help prevent and manage chronic musculoskeletal pain because older individuals who are not physically active may have less muscle strength and a higher risk of impairment and injury than physically active persons. as a result, a tailored exercise program may prevent the loss of health-related quality of life among diverse elderly. this study aimed to develop a structured exercise module and identify its effect on musculoskeletal pain and the quality of life of older adults.

background: the rate of musculoskeletal pain among older people is increasing worldwide and significantly impacts the quality of life. regular exercise can help prevent and manage chronic musculoskeletal pain because older individuals who are not physically active may have less muscle strength and a higher risk of impairment and injury than physically active persons. as a result, a tailored exercise program may prevent the loss of health-related quality of life among diverse elderly. objectives: this study aimed to develop a structured exercise module and identify its effect on musculoskeletal pain and the quality of life of older adults. method: a quasi-experimental study was conducted among 60 older adults who experienced musculoskeletal pain in the east coast malaysia; pahang, terengganu, and kelantan between january and february 2021. a set of questionnaires contained three parts; part a: socio-demographic background, part b: musculoskeletal pain (pain score), and part c: functional limitation. data was collected using a self-administered questionnaire through an online survey. data collection processes go through three phases. phase i: pre-intervention phase, phase ii: intervention session, and phase iii: post-intervention.

Eligibility criteria:
inclusion criteria: * older adults aged 60 years old and above * lives in east malaysia; pahang, kelantan, and terengganu * have the mental capacity to give informed consent * had musculoskeletal pain exclusion criteria: * had severely impaired hearing and sight that may have affected their ability to use the self-report scales * had neurological diseases or cognitive impairment * had a recent self-reported history of stroke or major surgery (in the past 6 months).

Keywords: older people musculoskeletal pain quality of life exercise training programme
efficacy and safety of brolucizumab vs aflibercept in patients with visual impairment due to diabetic macular edema

Conditions: Diabetic Macular Edema

Summary: the purpose of this study was to evaluate the efficacy and safety of brolucizumab vs. aflibercept in the treatment of patients with visual impairment due to diabetic macular edema (dme).

this study was designed as a phase iii, multi-center, randomized, double-masked, active controlled, parallel group prospective study to evaluate if brolucizumab 6 mg dosed q4w is safe and effective in the treatment of subjects with visual impairment due to diabetic macular edema (dme). subjects who met all the inclusion and none of the exclusion criteria were randomized in a 2:1 ratio to one of two treatment arms i.e., brolucizumab 6 mg and aflibercept 2 mg. only one eye was selected as study eye and treated with study medication. the study included a screening period of up to 2 weeks to assess eligibility, followed by a double-masked treatment period (day 1 to week 48). for all subjects, the last study assessment was performed at the week 52/end of study (eos) visit. all subjects had study visits q4w through week 52. the primary analysis was performed at the eos visit (week 52). to ensure masking was maintained, the investigational site had both masked and unmasked staff to perform the masked and unmasked study assessments/procedures accordingly.

Eligibility criteria:
inclusion criteria: * signed informed consent must be obtained prior to participation in the study. * patients with type 1 or type 2 diabetes mellitus (dm) and hemoglobin a1c (hba1c) ≤ 12% at screening. * study eye: visual impairment due to dme with: * best-corrected visual acuity (bcva) score between 73 and 23 letters, inclusive, using early treatment diabetic retinopathy study (etdrs) visual acuity testing charts at an initial testing distance of 4 meters * dme involving the center of the macula, with central subfield thickness (csft) ≥ 320 µm on spectral domain optical coherence tomography (sd-oct) exclusion criteria: * high-risk proliferative diabetic retinopathy (pdr) in the study eye * concomitant conditions or ocular disorders in the study eye which confound interpretation of study results, compromise visual acuity or require medical or surgical intervention * any active intraocular or periocular infection or active intraocular inflammation in the either eye * uncontrolled glaucoma in the study eye * presence of amblyopia, amaurosis or ocular disorders in the fellow eye with bcva \<20/200 * use of anti-vegf therapies, intraocular surgery or laser photocoagulation (macular or panretinal) in the study eye during the 3-month period prior to baseline * use of intraocular or periocular corticosteroids in the study eye during the 6-month period prior to baseline, and use of fluocinolone acetonide intravitreal (ivt) implant (iluvien) at any time prior to baseline * prior investigational drugs in either eye, vitreoretinal surgery in the study eye at any time prior to baseline

Keywords: diabetic macular edema intravitreal injection brolucizumab aflibercept double-masked diabetic macular edema (dme) macular edema diabetic retinopathy