Kornimate/medical-research-clean huggingface dataset:
a longitudinal study of multimodal resonance imaging in stroke patients

Conditions: Stroke

Summary: imaging of the ischaemic penumbra with a particular diffusion-weighted imaging (dwi)/ perfusion-weighted imaging (pwi) mismatch is a promising approach to the selection of patients with acute ischaemic stroke for trials of intervention. the investigators want to apply multimodal resonance imaging methods such as functional magnetic resonance imaging ( fmri), diffusion tensor imaging (dti), arterial spin labeling (asl) to guide treatment and predict the prognosis of stroke.


Eligibility criteria:
inclusion criteria: time from the onset of stroke till hospital within 24 hours. with clinical characteristics such as hemiplegia, headache. willing and able to comply with the study procedures and provide written informed consent to participate in the study. patients must understand the nature of the study and give informed consent. exclusion criteria: the onset of stroke out of 24 hours. pregnant women. patients with intracranial metallic bodies from prior neurosurgical procedure, implanted pacemaker, medication pump, vagal stimulator, deep brain stimulator, tens unit or ventriculoperitoneal shunt. past history of seizures within one year or unexplained loss of consciousness. family history of epilepsy.

Keywords: stroke fmri dti
retrospective brazilian study of fulvestrant in advanced breast cancer

Conditions: Breast Cancer

Summary: characterize the demographic and clinical features, as well as the main treatment results, among patients with advanced breast cancer treated with fulvestrant in brazil.


Eligibility criteria:
inclusion criteria: * positive hr or er by immunohistochemistry * postmenopausal status at the time of treatment with fulvestrant * failure of at least one previous endocrine therapy before treatment with fulvestrant. exclusion criteria: * patients who are still undergoing treatment with fulvestrant will not be eligible to participate in the study

Keywords: advanced breast cancer hormone therapy
open-label depakote er in patients with bipolar i or ii depression and alcohol abuse or dependence

Conditions: Bipolar I or II Depression and Alcohol Abuse or Dependence

Summary: the purpose of this study is to determine if divalproex sodium can be used to treat and prevent depression in patients with bipolar disorder who have comorbid alcohol dependence/abuse.

over half of all patients with bipolar disorder have comorbid substance abuse. the most common substance of abuse is alcohol, which is most commonly associated with the depressed phase of the illness. although there are available treatments for bipolar depression, no studies have been done to evaluate efficacy in bipolar patients with comorbid substance abuse disorders. given the independent open-label evidence for efficacy and safety of divalproex sodium in alcohol abuse and bipolar depression, divalproex sodium is the most likely candidate for potential success in bipolar depressed patients with comorbid alcohol abuse or dependence. the purpose of this study is to determine if divalproex sodium can be used to treat and prevent depression in patients with bipolar disorder who have comorbid alcohol dependence/abuse.

Eligibility criteria:
inclusion criteria: * madrs \>= 20 at screen and 18 at baseline * ymrs =\< 11 at screen and baseline * dms-iv criteria for past manic or hypomanic episode based on the scid * dsm-vi criteria for alcohol dependence or abuse based on the scid. * alcohol dependence/abuse confirmed by corroboration from family member * negative urine pregnancy test exclusion criteria: * inability to give informed consent * inability to give reliable assessment of alcohol consumption * evidence of alcohol consumption one week prior to baseline * liver function tests greater than 3x upper limit of normal at screen * history of active hepatitis or hepatic encephalopathy * history of pancreatitis * history of adverse reaction to divalproex sodium * history of seizure other than directly associated w/prior alcohol withdrawl * history of major head trauma with loc \> 10 min. or skull fracture * hisotry of hypertension or neurologic illness * if female, not practicing an effective form of birth control

Keywords: bipolar i or ii depression alcohol abuse or dependence mental health issues
hcv virions bound proteins

Conditions: Hepatitis C

Summary: the emergence of hepatocellular carcinoma (hcc) has prompted a search for a thorough understanding of the biology of one of its major causative agents, the hepatitis c virus (hcv). hcv particles acquire via budding and encapsidation cellular proteins. there is mounting evidence on several viral species that virion-bound proteins are prone to be involved either at the replication, budding/egress or entry/release steps of the viral cycle. identifying such targets may yield ideal candidates for gaining insight on the dependence of hcv upon a restricted subset of host proteins, therefore providing refined sets of genetically stable targets for therapy. this project's goals are to set up adequate conditions for robust and reproducible purification of hcv virions in clinical samples, followed by the identification of their hcv-bound host proteins and the characterization of their functions. proteomics profiling of hcv particles purified from clinical samples will be overlaid with proteins identified and characterized in cell culture grown hcv particles during my post-doctoral training, using clinical biomarker discovery grade criteria. targets identified in both samples sets will be subjected to in vitro investigations using hcv-replicating cells. conventional biochemical and imaging methods will be used in order to: (i) ascertain their physical association with hcv virions; (ii) define the modalities of their interaction with hcv proteins; (iii) decipher the topology and subcellular localization of their association with hcv proteins and virions; (iv) quantitatively assess their functional involvement in particle budding, egress or secretion and infectivity. a candidate that yielded satisfactory results in these experiments will be disclosed and further investigated at the level of structural biology, in collaborative research programs.


Eligibility criteria:
inclusion criteria: * adult\> 18 and \<60 years * infected with hcv genotype 1 hcv antibody positive. * positive viremia for more than 6 months * viremia\> 106 iu / ml. * nonresponders to previous treatment and without antiviral treatment for 2 months. * for control samples: patients responders to previous treatment and without antiviral treatment for 2 months. exclusion criteria: * patient receiving or having received antiviral treatment within two months. * patient with against-indication for a blood sample of 150 ml * immunosuppressive therapy patient * patient with liver disease other than hepatitis c. * patients with cirrhosis. * patient with hepatocellular carcinoma. * patients with one or more severe co-morbidities defined as: * co-infection with hiv or hbv. * hematological malignancies changing or aplasia * insulin-dependent diabetes * dialyzed chronic renal failure * heart failure * persons subject to legal protection or the subject of a safeguard measure of justice not affiliated with a social security scheme or not beneficiaries of such a scheme * pregnant women

Keywords: hcv, liver
current adoption of composite indices in evaluating rheumatoid arthritis patients: an observational study

Conditions: Rheumatoid Arthritis

Summary: this is an observational study of composite indices, including the clara (clinical arthritis activity) index, in rheumatoid arthritis (ra) patients in routine clinical practice in italy in order to evaluate clinical remission and low disease activity. data will be collected only from patients providing informed consent. in this study we aimed to assess the psychometric properties of a new composite instrument termed clinical arthritis activity (pro-clara) that uses only three pro measures from among the 7 acr core data set. we hypothesized that this index would facilitate rapid and easy ra activity assessment in daily routine.

all patients who respond to inclusion/exclusion criteria at baseline will be considered valuable for the analysis.

Eligibility criteria:
inclusion criteria: * eighteen years of age or older with diagnosis of ra based on the 1987 american college of rheumatology (acr) criteria and in accordance with local guidelines. * patients eligible to anti-tnf therapy * patients naïve to anti-tnfa drugs * patients with radiography (hands and feet) executed by 6 months before the baseline or at baseline according to modified sharp van der hejde method \[sharp jt et al. 1985; sharp jt. et al. 1989; van der heijde dm et al. 1989\] patients capable of understanding and completing the questionnaire patients capable of understanding and signing an informed consent form exclusion criteria: * patients with tumors * patients already included in clinical trials

Keywords: observational cohort prospectives multicentre the italian study ra patient clara and pro-clara
effects of core stabilization training with and without pressure biofeedback in patients with low back pain

Conditions: Low Back Pain

Summary: mechanical low back pain is an impairment of musculoskeletal system. lifetime prevalence of low back pain is 60-85%. frequent micro-trauma to the structures of the spine, poor control and stabilization leads to lbp and eventually causes functional limitation. the objective of the study to find whether core stabilization training with pressure biofeedback could reduce pain and improves functional activity in patients with mechanical low back pain. to study the effectiveness of core stabilization training with pressure biofeedback in reducing pain and improving functional activity in subjects with mechanical low backpain between the age group of 25-40 years. to find out the effect of core stabilization training with pressure biofeedback in reducing pain and improving functional activity in subjects with mechanical low back pain between the age group of 25-40 years. the study will be conducted on 30 subjects between the age group of 25-40 years with mechanical low back pain and according to the inclusion criteria were recruited in the study. nprs at rest and activity, modified odi will assess pre and post treatment. p value: less than 0.05 using spss (statistical package for social sciences) for nprs(pain at rest and activity) and modified odi i.e. core stabilization training with pressure biofeedback had statistical improvement in nprs (pain at rest and activity) and modified odi score. core stabilization training with pressure biofeedback is effective inreducing pain (at rest and activity) and functional disability in subjects between the age group of 25-40 years with mechanical low back pain


Eligibility criteria:
inclusion criteria:\\ * male and female patients between the age group 25-40 years having mechanical low back pain persisting for at least 6 months upto1 year. * patients complaining pain when sitting or standing for a long period or pain when driving long distance, getting in and out of the car or lifting activities. * patients with minimum and moderate disability based on modified oswestry disability index (odi). * patients with greater than and equal to 7 score on nprs. exclusion criteria: * structural deformity (scoliosis, lordosis). * systematic inflammatory disease (vasculitis, connective tissue disease and granulomatous disease). * nerve root compression (disc bulge and lumbar radiculopathy). * history of spinal surgery or fractures (laminectomy).

Keywords: pain back core stabilization pressure biofeedback
the impact of 8 weeks of a digital meditation application on work stress

Conditions: Stress, Psychological; Behavioral Symptoms

Summary: the aim of this study is to test the effects of a digital meditation intervention in a sample ucsf employees who report mild to moderate stress. we will randomize ucsf employees to either 8-weeks of a digital meditation intervention (using the commercially available application headspace) or a waitlist control condition.

the aim of this study is to test the effects of a digital meditation intervention in a sample ucsf employees who report moderate to high stress. we will randomize ucsf employees to either 8-weeks of a digital meditation intervention (using the commercially available application headspace) or a waitlist control condition. participants assigned to the intervention group will be asked to download and use the headspace mobile application for at least 10 minutes per day for 8 weeks. all study participants will be asked to fill out short (no longer than 25 minutes) questionnaires at baseline, week 4, week 8 (post intervention), and a 4-month follow up period. among participants who are randomized to the digital meditation intervention, they will also take part in a 1-year follow up. all activities will take place online (via computer or smartphone). prior to randomization, participants will go through an eligibility screening and complete the baseline questionnaire battery. the entirety of the study is digital and there are no in-person assessments. adherence will be tracked remotely. the goal is to recruit as many as 2000 participants (1000 per condition).

Eligibility criteria:
inclusion criteria: you may join if you: * have access to a smartphone or computer every day * are fluent in english * are a ucsf employee * report mild to moderate levels of stress * consent: demonstrate understanding of the study and willingness to participate as evidenced by voluntary informed consent and has received a signed and dated copy of the informed consent * are at least 18 years of age exclusion criteria: • you may not join if you are an experienced meditator or have participated in a formal meditation practice in the last 3 months (defined as 3 times per week or more for 10 minutes or more at each practice)

Keywords: stress health meditation mindfulness employees job strain burnout work mood affect work related stress
norepinephrine for hypotension in cesarean section

Conditions: Hypotension; Cesarean Section

Summary: hypotension is a very common consequence of the sympathetic vasomotor block caused by spinal anesthesia for cesarean section. maternal symptoms such as nausea, vomiting and dyspnea frequently accompany severe hypotension, and adverse effects on the fetus, including depressed apgar scores and umbilical acidosis, have been correlated with severity and duration of hypotension. because hypotension is frequent, vasopressors should be used routinely and preferably prophylactically.

phenylephrine has a potent direct α effect, with virtually no β effects at clinical doses, however when given at higher than required doses, it may induce baroreceptor-mediated bradycardia with a consequent reduction in maternal cardiac output. although α agonist drugs are the most appropriate agents to treat or prevent hypotension following spinal anaesthesia, those with a small amount of β agonist activity may have the best profile (noradrenaline (norepinephrine) and metaraminol. phenylephrine is currently recommended due to the amount of supporting data.noradrenaline is the primary catecholamine released by postganglionic adrenergic nerves. it is a potent α adrenergic agonist, with comparatively modest β agonist activity.

Eligibility criteria:
inclusion criteria: * patients who fall in category 2 and 3 according to the classification of caesarean section made by royal college of obstetrician and gynaecologists. exclusion criteria: * patient refusal either to study enrollment or to spinal anesthesia. * any absolute contraindication to spinal anesthesia e.g. coagulopathy, skin infection at site of injection. * allergy to any of study drugs. * patients with cardiac morbidities, hypertensive disorders or peripartum bleeding * bmi \> 40 kg/m² * baseline systolic blood pressure \< 100 mmhg.

Keywords: post spinal anesthesia
infant & toddler short gut feeding outcomes study

Conditions: Short Bowel Syndrome; Intestinal Failure; Home Parenteral Nutrition

Summary: the purpose of this study is to better understand why children with short gut develop feeding problems.

we seek to identify characteristics of our patients' histories that are associated with feeding problems in the context of availability of early prophylactic occupational therapy. we plan to review our most recent four years' experience in children with short gut syndrome with onset in early infancy who initially required home parenteral nutrition to identify risk factors or clusters of risk factors associated with food aversion.

Eligibility criteria:
inclusion criteria: * patients seen in home-tpn clinic since july of 2008 with: * intestinal failure * short gut * onset \< 3 months of age * received home parenteral nutrition following initial hospital discharge * less than 7 years of age at time of study * must have at least 1 parent/legal guradian willing to participate in the study exclusion criteria: * not seen in home tpn clinic * short gut with onset \>3 months * no parents/legal guradians willing to participate in the study

Keywords: short gut short bowel syndrome intestinal failure home parenteral nutrition feeding behavior enteral nutrition parent-child relations parenteral nutrition digestive system diseases
dermatosis papulosa nigra

Conditions: Facial Dermatoses; Seborrheic Keratoses

Summary: dpn is a disorder among darkly pigmented patients, manifested by small, benign, variants of seborrheic keratoses, predominantly on the face. the purpose of this study is to determine the efficacy of a 585 nm pdl for the treatment of dermatosis papulosa nigra, and compare it to therapy with curettage (scraping the lesions off) and electrodesiccation (burning the lesions off).


Eligibility criteria:
inclusion criteria: * over 18 years of age. * able to give informed consent. * desires removal of lesions. * willing to come back for six week follow-up. * willing to fill out post operative questionnaire. * at least 4 lesions less than 7 mm. * diagnosis of dermatosis papulosa nigra (dpn) exclusion criteria: * less than 18 years of age. * pregnant. * sensitive to laser energy. * history of collagen vascular disorders. * history of keloids. * history of post inflammatory hyperpigmentation. * incarcerated. * unable to give informed consent. * unable to follow up for post operative evaluation. * unable to complete patient visual analogue scale. * unable to understand consent process or risks. * unable to accept risk of scar, infection, minor bleeding, permanent or prolonged hyperpigmentation and hypopigmentation.

Keywords: dermatosis papulosa nigra seborrheic keratoses
recombinant factor viia in acute intracerebral haemorrhage

Conditions: Acquired Bleeding Disorder; Intracerebral Haemorrhage

Summary: this trial is conducted in north america, europe, asia and oceania. the purpose of this study is to evaluate safety and efficacy of recombinant factor viia in patients with acute intracerebral bleeding.


Eligibility criteria:
inclusion criteria: * spontaneous intracranial haemorrhage (ich) within 3 hours after first symptom exclusion criteria: * patients with secondary ich * pre-existing disability * haemophilia
intra-wound vancomycin powder for prevention of surgical site infection following spinal surgery

Conditions: Infection

Summary: cefazolin is given routinely pre and intraoperatively for patients undergoing spinal surgery to reduce the rate of infection. intra-wound admission of vancomycin powder has been suggested to reduce wound infection rates. therefore, this study aims to compare the rate of wound-related complications between patients receiving standard treatment compared to patients receiving an addition of topical vancomycin and to identify the optimal vancomycin dosage. all groups will receive the recommended regimen of routine iv antibiotic prophylaxis.


Eligibility criteria:
inclusion criteria: * patients undergoing posterior spinal fusion operation at the neurosurgery department at the rabin medical center * ability to understand and sign written informed consent by the patient or legal guardian exclusion criteria: * preoperative ongoing infectious disease present as judged by the primary surgeon (based on lab results and clinical assessment) * receiving ongoing treatment of antibiotics for other infections * sensitivity or allergy to vancomycin or cefazolin * previous spine surgery at the index level within the last 90 days * postoperative radiotherapy of the surgical site required (e.g. for tumor) * renal insufficiency with stage 4 chronic kidney disease (ckd) with a glomerular filtration rate (gfr) of 15-30 ml/min or worse * undergoing spinal decompression only * trauma patients * pregnancy

Keywords: vancomycin infections surgical site
use of methazolamide to lower intraocular pressure

Conditions: Glaucoma, Open-Angle

Summary: the purpose of this study is to evaluate the effect of methazolamide, 25 mg or 50 mg tablets once a day for a week than twice a day for a week, on lowering intraocular pressure and the safety of methazolamide.


Eligibility criteria:
inclusion criteria: * males and females between 50 and 90 years old * current diagnosis of open angle glaucoma (oag) in both eyes * ability to read and write in english exclusion criteria: * glaucoma other than oag * severe or end-stage glaucoma (cup to disc ratio \>0.8 or mean deviation on visual field worse than -12) * pregnant or breast-feeding women

Keywords: glaucoma methazolamide primary open angle glaucoma
a randomized study with oral melphalan + prednisone (mp) versus melphalan, + prednisone + thalidomide (mpt) for newly diagnosesd elderly patients with multiple myeloma

Conditions: Multiple Myeloma

Summary: the aim of the study is to compare efficacy and toxicity of melphalan and prednisone versus meplhalan, prednisone and thalidomide in elderly patients with multiple myeloma or patients with multiple myeloma but not eligible for high dose treatment with stem cells support.


Eligibility criteria:
inclusion criteria: * newly diagnosed of multiple myeloma. * age \> 65 years * ecog \<= 3 * written informed consent given at the time of randomization * patients with age \<= 65 but not eligible for high dose treatment with stem cells support exclusion criteria: * ecog \> 3 * current neoplasm.. * contraindications to use thalidomide * peripheral neurophaty

Keywords: multiple myeloma elderly patients