Kornimate/medical-research-clean huggingface dataset:
effect of semiconductor embedded therapeutic gloves for hand osteoarthritis

Conditions: Hand Osteoarthritis; Osteoarthritis

Summary: the goal of this study is to evaluate change in symptoms using semiconductor embedded gloves for hand osteoarthritis.

the semiconductor embedded fabric emits mid-level and far infrared waves and negative ions to the tissue which can increase circulation of both blood and lymph, plus facilitates the anti-inflammatory nitric oxide cascade by accelerating the binding of calcium to calmodulin. nitric oxide down-regulates interleukin1 beta and inducible nitric oxide synthase in certain cell types, which leads to reduced cyclooxygenase-2 and prostaglandins-molecules responsible for causing inflammation and pain. unlike other systemic cox-2 inhibitors such as nonsteroidal anti-inflammatory drugs (nsaids), targeted infrared and negative ion therapy stimulate localized reaction pathways, thereby reducing pain and inflammation. this study seeks to identify patient reported subjective and clinically measured objective outcomes for hand osteoarthritis pain management and hand function with application of semiconductor embedded fabric in the affected area.

Eligibility criteria:
inclusion criteria: 1. patients diagnosed with erosive hand oa, non-erosive hand oa, or first carpometacarpal joint oa with a kellgren- lawrence grade \>1 as determined by radiographic assessments and the american college of rheumatology (acr) classification 2. patients age 40-75 3. patients who are willing and able to adhere to follow-up schedule and protocol guidelines. 4. patients who are willing and able to sign corresponding research subject consent form. exclusion criteria: 1. patient has a history of neurological conditions, including multiple sclerosis or parkinson's disease 2. patient has had prior surgical treatment of the hands in the last 5 years or injection treatment in the last 6 months 3. patient has secondary oa including causes such as gout, rheumatoid arthritis, psoriatic arthritis 4. patient has used topical creams or gels for arthritic pain including nonsteroidal anti-inflammatory drugs, capsaicin, lidocaine, or counterirritants in the last 1 week 5. patient has a history of carpal tunnel syndrome, cubital tunnel syndrome, or radial tunnel syndrome 6. patient has a history of peripheral neuropathy 7. patient has chronic pain conditions unrelated to hand condition 8. patient has auto-immune or auto-inflammatory diseases 9. patient has used tobacco within the last 90 days 10. patient is not within the ages of 40-75 11. patient has an active infection (local or systemic) 12. patient is unwilling or unable to sign the corresponding research subject consent form 13. patient meets any other criteria or has any other condition that, in the opinion of the investigator, would prevent them from completing the study or that, in the opinion of the investigator, would confound study results. - exclusion criteria: -

Keywords: semiconductor embedded fabric gloves for hand osteoarthritis
mid-point transverse process to pleura block for breast cancer surgery: a randomized controlled trial

Conditions: Breast Cancer; Acute Pain; Anesthesia

Summary: this study will compare the analgesic effects of midpoint transverse process to pleura (mtp) block to control as well as thoracic paravertebral block.

paravertebral blocks (pvbs) are frequently used for regional anesthesia for breast surgery. ultrasound-guided paravertebral block is an advanced skill. the needle tip can be difficult to visualize with ultrasound, and the proximity to neurovascular structures as well as the pleura presents a risk of neurovascular injection and pneumothorax respectively. the midpoint transverse-process to pleura (mtp) block incorporates a novel needle endpoint that is technically easier to achieve and more distant from neurovascular structures and the pleura compared to traditional pvb. this study will compare the analgesic effects of mtp block to control and pvb.

Eligibility criteria:
inclusion criteria: * english or french speaking * scheduled for major breast surgery * asa physical status classification i-iii * bmi \<30kg/m2 exclusion criteria: * prior ipsilateral breast surgery * pre-existing neurological deficit or peripheral neuropathy involving the ipsilateral chest * contraindications to regional anesthesia * patient refusal of regional technique * chronic pain disorder * chronic opioid use * inability to provide informed consent

Keywords: regional anesthesia paravertebral block breast cancer surgery mtp block
routine and deferred dialysis initiation

Conditions: Chronic Kidney Disease

Summary: this study evaluates the efficacy and safety of deferred dialysis initiation in chinese population. 16 tertiary hospitals across china will be randomly assigned into routine and deferred dialysis groups.

the timing for initiating dialysis for progressive chronic kidney disease (ckd) patients is an important issue yet is not well established. there is a strong trend to early dialysis initiation for end stage renal disease (esrd) patients over the past decades. however, observational data found that early initiation seemed to produce no benefit but additional burden to patients and the health care system. the ideal study, the only randomized, controlled trial (rct) on this issue, found that all-cause mortality, comorbidities and quality of life had no difference between early (glomerular filtration rate, gfr 10-14ml/min/1.73m2) and late (gfr 5-7ml/min/1.73m2) dialysis starters. however there was a big limitation in this study that the difference for average gfr between two groups (12 ml/min/1.73 m2 vs. 9.8 ml/min/1.73m2) was not so separate. recently, the canadian society of nephrology have released a clinical practice guideline on this issue. the guideline recommends an "intent-to-defer" approach for dialysis initiation and to initiate dialysis in the absence of symptoms in patients with an estimated gfr of 6 ml/min /1.73 m2 or less. in this guideline the specialists also express that the optimal management of patients with an estimated gfr of 6 ml/min per 1.73 m2 or less is based on limited data. there is a gap in knowledge. this research will further evaluate the efficacy and safety of deferred dialysis initiation and fill in this gap. in this study, algorithms will be adopted to determine the timing of dialysis initiation for both routine and deferred dialiysis groups, and the only difference in these two algorithms is the gfr level to initiate dialysis (7 vs. \<5 ml/min per 1.73 m2). the theory that blood access (arteriovenous fistulas) can be timely prepared according to the past gfr decline trajectory will also be tested.

Eligibility criteria:
inclusion criteria: 1. nondialysis-dependent stable ckd stage 4-5 patients (egfr\>7ml/min /1.73 m2) 2. willing to choose dialysis as his renal replacement therapy method 3. heart function: grade i or ii (nyha functional classification) exclusion criteria: 1. the life expectancy of patients is estimated to be short (due to causes other than kidney disease); 2. acute infection occurred in one month; 3. myocardial infarction, nyha class iv or stroke events within 3 months; 4. uncontrolled malignancy; 5. active viral hepatitis; 6. active rheumatic disease; 7. pregnant women, women intending to conceive after enrollment or breastfeeding woman; 8. planning to take kidney transplantation within the study period; 9. with indices of emergency dialysis; 10. egfr less than 7 ml/min/1.73m2 in first visit; 11. under other clinical studies which has an impact on this study; 12. unable to provide written informed consent.
a phase 2 study in patients with advanced non-small cell lung cancer using new agents with and without docetaxel.

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: to determine the effectiveness of cp-868,596 + docetaxel, ag-013736 + docetaxel and cp-868,596 + ag-013736 + docetaxel in patients previously treated for non-small cell lung cancer.


Eligibility criteria:
inclusion criteria: * platinum-pretreated patients with advanced stage iiib or iv nsclc exclusion criteria: * centrally-located tumors
safety study of proquad® rha in infants (v221-037)

Conditions: Measles; Mumps; Rubella; Varicella

Summary: primary objective: to describe the safety profile of a second dose of proquad® manufactured with recombinant human albumin (rha) when administered to children in their second year of life. secondary objectives: to describe the safety profile of a first dose of proquad® manufactured with rha when administered to children in their second year of life.


Eligibility criteria:
inclusion criteria: * healthy subject of either gender, * age from 12 to 22 months, * negative clinical history of infection with measles, mumps, rubella, varicella or zoster, * informed consent form signed by the parent(s) or by legal representative * parent(s) or legal representative able to attend all schedule visits with the subject and to understand and comply with the study procedures exclusion criteria: * recent (≤ 3 days) history of febrile illness * prior receipt of measles, mumps, rubella and/or varicella vaccination, either alone or in any combination * recent (≤ 30 days) exposure to measles, mumps, rubella, varicella or zoster * prior known sensitivity/allergy to any component of the vaccine * severe chronic disease, * blood dyscrasias, leukaemia, lymphomas of any type, or other malignant neoplasms affecting the haematopoietic and lymphatic system * any severe thrombocytopenia or any other coagulation disorder that would contraindicate intramuscular injection * humoral or cellular immunodeficiency, * current immunosuppressive therapy * family history of congenital or hereditary immunodeficiency * hereditary problems of fructose intolerance * known personal history of encephalopathy, seizure disorder or progressive, evolving or unstable neurological condition, * known active tuberculosis * recent (≤ 2 days) tuberculin test or scheduled tuberculin test through visit 3 * receipt of immunoglobulins or blood-derived products in the past 150 days * receipt of an inactivated vaccine in the past 14 days * receipt of a live vaccine in the past 28 days * any medical condition which, in the opinion of the investigator, might interfere with the evaluation of study objectives * participation in another clinical study in the past 30 days

Keywords: prevention of: measles, mumps, rubella and varicella
evaluating shared decision-making for lung cancer screening among chinese populations in the united states

Conditions: Cigarette Smoking-Related Carcinoma

Summary: this study better understands the views on shared decision-making among chinese adults who smoke or who have a spouse who smokes. lung cancer is the second most common cancer among men and women in the united states and is the number one cause of cancer-related mortality among asians and pacific islanders. clinicians are recommended to initiate conversations about lung cancer screening with eligible patients, provide information about the benefits and harms, and engage in shared decision-making. however, a patient's cultural background can influence decision-making in many ways. given this, there is a need to understand the perceptions of shared decision-making among different populations (in this case, asian populations) in order to inform the design of culturally sensitive decision aids for cancer screening. this study evaluates how chinese populations in the u.s. who currently smoke or who have partners who smoke perceive the process of shared decision-making, their preferences, the perceived barriers and facilitators, and their perspective on currently-available screening tools.

primary objectives: i. understand how chinese populations in the unites states who currently smoke or who have partners who smoke perceive the process of shared health-related decision-making and their preferences in terms of role involvement, and the barriers to and facilitators of shared decision-making. ii. evaluate current publicly available lung cancer screening tools from the perspective of chinese adults who smoke or who have partners who smoke. outline: participants attend an interview over 45-60 minutes and/or a focus group over 1.5 to 2 hours.

Eligibility criteria:
inclusion criteria: * men and women who self-identify as chinese * live in the u.s. (either citizens or have lived in the u.s. for at least 5 years or more, i.e. long-term residents) * age 50-80 * currently smokes or partner of a person who smokes * speak english and/or mandarin
evaluating the use of sr34006 compared to warfarin or acenocoumarol in patients with atrial fibrillation (amadeus)

Conditions: Atrial Fibrillation

Summary: this trial will include patients who have a heart condition called atrial fibrillation. atrial fibrillation is an abnormal rhythm (irregular beat) in the heart. patients with atrial fibrillation have an increased chance for a blood clot to form in the heart and move to other blood vessels in the body and cause obstruction. this obstruction may damage tissue. for example, a blood clot plugging a vessel in the brain could cause a stroke. therefore, patients with atrial fibrillation may be given anticoagulant (blood-thinning) tablets such as warfarin or acenocoumarol. the purpose of this study is to compare the safety and effectiveness of a new injectable anticoagulant drug that is administered once weekly, sr34006 with warfarin or acenocoumarol tablets. assignment to either sr34006 injection or vitamin k antagonist (warfarin or acenocoumarol) tablets will be purely by chance and will be known by both patients and their doctors.


Eligibility criteria:
inclusion criteria: * ecg-documented atrial fibrillation (af) and an indication for long-term vitamin k antagonist (vka) therapy based on the presence of at least one of the following risk factors: 1. previous ischemic stroke, transient ischemic attack (tia) or systemic embolism 2. hypertension requiring drug treatment 3. left ventricular dysfunction (left ventricular ejection fraction \<45% or symptomatic congestive heart failure) 4. age \>75 years 5. age between 65-75 years plus diabetes mellitus, or 6. age between 65-75 years plus symptomatic coronary artery disease (previous myocardial infarction (mi) or angina pectoris) * written informed consent exclusion criteria: * legal lower age limitations (country specific) * indication for vka other than af, including prosthetic heart valves, venous thromboembolism, and planned cardioversion * transient af caused by a reversible disorder * active bleeding or high risk of bleeding * recent (\<15 days) or anticipated invasive procedures with potential for uncontrolled bleeding, including major surgery * participation in another pharmacotherapeutic study within the prior 30 days * creatinine clearance \<10 ml/min, severe hepatic disease, or bacterial endocarditis * uncontrolled hypertension: systolic blood pressure \> 180 mm hg and/or diastolic blood pressure \> 110 mm hg * pregnancy or childbearing potential without proper contraceptive measures * breastfeeding * any other contraindication listed in the labeling of warfarin or acenocoumarol
systane complete multi-symptom relief

Conditions: Dry Eye Disease

Summary: the purpose of this study is to demonstrate effective symptom relief with the use of systane complete among subjects with dry eye disease (ded).

subjects will be expected to attend a screening/baseline visit and one additional visit at day 28 (± 2 days), with a telephone call visit conducted at day 14 (± 2 days). individual duration of subject participation will be approximately 28 days.

Eligibility criteria:
key inclusion criteria: * able to understand and sign an institutional review board (irb)/independent ethics committee (iec) approved informed consent form. * willing and able to attend all study visits as required per protocol. * have dry eye symptoms as specified in the protocol. * willing to discontinue use of all habitual artificial tear supplements for the entire study duration. * other protocol-defined inclusion criteria may apply. key exclusion criteria: * ocular conditions as specified in the protocol. * contact lens use within one week prior to screening visit. * use of medications as specified in the protocol. * pregnant or breast feeding. * other protocol-defined exclusion criteria may apply.

Keywords: eye drops
measurement of jugular venous pulse in critically ill patients.

Conditions: Jugular Venous Pulse Measurement in Critically Ill Patients

Summary: to assess the utility of clinical bedside examination for the measurement of jugular venous pulse in critically ill patients.

procedures: all patients with central venous catheters (cvp) will undergo physical examination of the jugular veins, while blinded to the actual cvp measured from the catheter. clinicians with various experience levels (attending physician, fellow, resident physician, 4th year medical student) will participate. the following clinical data will be obtained: demographic data such as age, sex, weight and diagnosis will be collected. each clinician's bedside cvp will be recorded from the bedside monitor. clinicians will be blinded to bedside monitor.

Eligibility criteria:
inclusion criteria: * all patients admitted to the icu who have existing central venous catheters. exclusion criteria: * patients admitted to the icu who do not have existing central venous catheters

Keywords: jugular venous pulse
comparison of carotid peak systolic velocity variation with aortic peak systolic velocity variation in pediatric non-cardiac surgery

Conditions: Anesthesia, General; Anesthesia, Endotracheal; Mechanical Ventilation; Fluid Responsiveness

Summary: the purpose of this study is to evaluate whether carotid doppler peak systolic velocity can be an easy to measure possible surrogate for echocardiographic measurement of aortic peak systolic velocity variation which is an index of fluid responsiveness in mechanically ventilated children intra-operatively.


Eligibility criteria:
inclusion criteria: • patients scheduled for mon-cardiac surgeries under general endotracheal anaesthesia in supine position with expected duration more than 1 hour exclusion criteria: * known congenital heart disease * any non-sinus rhythm, arrhythmias * patients on vasoactive medications * chest wall deformities, situs non solitus (eg. dextrocardia) * patients scheduled for open chest surgeries * history of neck surgery/ carotid interventions

Keywords: fluid responsiveness pediatric surgery general endotracheal anaesthesia
strength-endurance circuit training in parkinson's disease

Conditions: Parkinson Disease, Idiopathic

Summary: the goal of this clinical trial is to determine whether adding strength training to aerobic training has a comparable or greater effect on the clinical status of parkinson's disease patients than a standalone aerobic training. - does combined strength-endurance circuit training provide added benefits to physical performance, disease severity, blood biomarkers, and quality of life in pd patients compared to standalone aerobic training? participants will: * undergo outcome measurements before and after the 12-week intervention and a 3-month follow-up measurement, * visit the clinic twice a week for 1-hour training sessions. * selected patients will be given a smartwatch with a pedometer that will count their average number of steps before, during and after the training period


Eligibility criteria:
inclusion criteria: * age ≥18 years * diagnosis of idiopathic parkinson´s disease * hoehn-yahr scale ≤ 2,5 * stable dopaminergic medication exclusion criteria: * age ≥75 years * hoehn-yahr scale ≥ 2,5 * deep brain stimulation * presence of freezing * camptocormia * inability to walk without support * inability to perform study procedures * limiting co-morbidities * attendance at training sessions below 70%

Keywords: parkinson disease strength training endurance training physiotherapy irisin quality of life physical performance
intraoperative transversus abdominis plane block for gynecologic surgery (gyntap)

Conditions: Postoperative Pain; Postoperative Nausea and Vomiting

Summary: this study attempts to learn about the effectiveness of a modification to the transversus abdominis plane (tap) block that works by anaesthetizing the sensory afferents of the abdominal wall postoperatively using ultrasound guidance. the investigators want to see if regional blocks placed by the surgeon intraoperatively to assure regional anesthetic spread in the appropriate plane could reduce error and improve postoperative recovery.

this study is a prospective, randomized blinded study that investigates the efficacy of a transversus abdominis plane block under direct view. in this pilot study involving gynecologic patients undergoing open (abdominal wall incision either vertically or horizontally) hysterectomy or other related gynecologic surgery, the investigators will use ropivacaine versus saline for the placebo control group, which in both groups involves injection of agent directly into the appropriate fascial layers prior to abdominal wall closure. efficacy is to be assessed via measurement of pain scores, nausea and vomiting, and opioid consumption in both participant groups. the number of dermatomes which are blocked in both participant groups during the first 24 hours following surgery will be recorded.

Eligibility criteria:
inclusion criteria: * age≥18 years old and not pregnant * must be able to provide informed consent - functional understanding of english * undergoes exploratory laparotomy with midline abdominal incision exclusion criteria: * history of substance abuse * history of chronic pain syndrome * daily opioid use for more than 1 month * patients considered to have chorioamnionitis at the time of cesarean surgery as determined by the attending physician * prior abdominal surgery involving mesh or placement of an ostomy site as this may disrupt the plane in which the anesthetic may spread * allergy to local anesthetics * history of cardiac arrhythmias or cardiac abnormalities * history of seizure disorder * liver disease
clinical related study on surgical treatment of knee joint meniscus injury

Conditions: Meniscus Injury

Summary: through the analysis of the data of 8094 patients with knee meniscus injury before december 31, 2008 and more patients with partial meniscus resection, subtotal resection and total resection, we can understand the gender difference and ratio of medial and lateral meniscus injuries. differences, differences in locations, differences in tearing methods, differences in surgical methods, and the course of the disease affect the meniscus injury and surgical methods, and further affect the patient's knee degeneration imaging, accompanying cartilage injury, knee osteoarthritis, partial resection, subtotal resection and meniscus regeneration after total resection, imaging and secondary arthroscopic exploration (second-look) were studied.

through the data of 8094 patients with knee meniscus injury who underwent surgery at the institute of sports medicine of the third hospital of beijing medical university before december 31, 2008, and the patients who underwent meniscus suture, partial resection, subtotal resection, and total resection. analyze and understand the influence of gender difference, ratio difference, position difference, tearing method difference, surgical method difference and disease course on the meniscus injury situation and operation method of the internal and lateral meniscus injury. observation and research will also be conducted on reports of knee cartilage injury, knee osteoarthritis, and meniscus regeneration after partial meniscus resection, subtotal resection and total resection.

Eligibility criteria:
inclusion criteria: before december 31, 2008, patients who underwent surgery for meniscus injury in this institute and patients who underwent meniscus suture, partial resection, subtotal resection, and total resection. exclusion criteria: -