Kornimate/medical-research-clean huggingface dataset:
comparison of verofilcon a daily disposable lenses to somofilcon a daily disposable lenses

Conditions: Myopia

Summary: the objective of the study is to evaluate and compare the performance of verofilcon a to somofilcon a when worn on a daily disposable modality over a period of approximately one week each.

the study is a prospective, double masked (investigator and participant), bilateral, randomized,one week cross-over dispensing study, which evaluates somofilcon a (test lens) and verofilcon a (control lens).

Eligibility criteria:
inclusion criteria: - a person is eligible for inclusion in the study if he/she: 1. is at least 17 years of age and has full legal capacity to volunteer; 2. has read and signed an information consent letter; 3. is willing and able to follow instructions and maintain the appointment schedule; 4. habitually wears soft contact lenses in daily wear, for minimum of 6-months; 5. is correctable to a visual acuity of 20/40 or better (in each eye) with the study lenses; 6. has an astigmatism of ≤ 1.00 d in subjective refraction; 7. can be fit with study contact lenses with a power between -2.00 and -5.00 ds; 8. demonstrates an acceptable fit with the study lenses; 9. habitually wears single vision soft contact lenses for at least 8 hours per day, 5 days a week, and is willing to wear contact lenses for at least 12 hours a day in the study. exclusion criteria: - a person may be excluded from the study if he/she: 1. is participating in any concurrent clinical or research study; 2. has any known active\* ocular disease and/or infection; 3. has a systemic condition that in the opinion of the investigator may affect a study outcome variable; 4. is using any systemic or topical medications that in the opinion of the investigator may affect a study outcome variable; 5. has known sensitivity to the diagnostic pharmaceuticals to be used in the study; 6. is pregnant, lactating or planning a pregnancy at the time of enrolment because the associated hormonal changes cause changes in the tear layer which impact contact lens comfort. verbal confirmation at the screening visit is sufficient; 7. is aphakic; 8. has undergone refractive error surgery; 9. is an employee of the centre for ocular research \& education; 10. has participated in the boxer (i.e. ex-mktg-107, phases 1 or 2) or miki (ex-mktg-114) study; 11. has participated in any clinical trials within a week prior to the study.
a comparison of endoscopic surgery and exercise therapy in patients with longstanding achilles tendinopathy

Conditions: Tendinopathy

Summary: exercise is a preferred treatment modality for mid-portion achilles tendinopathy. despite this, as many as 44 % of achilles tendinopathy patients do not respond to exercise treatment. surgery for midportion achilles tendinopathy has for many years been done as an open procedure. new knowledge resulted in a variety of minimally invasive procedures and the development of endoscopic surgery. in this study, the effect of non-open surgery and conservative treatment (physiotherapy and exercises) will be compared.


Eligibility criteria:
inclusion criteria: * diagnosis of mid-portion achilles tendinopathy * pain during at least 3 months * decreased function (a score less than 80 on visa-a) exclusion criteria: * physiotherapy during previous three months * history of major achilles trauma * cardiovascular, respiratory, systemic, or metabolic conditions limiting exercise tolerance

Keywords: achilles tendon endoscopy minimally invasive surgical procedures exercise therapy
immunotherapy in combination with chemoradiation in patients with advanced solid tumors

Conditions: Carcinoma, Squamous Cell of Head and Neck; Carcinoma, Non-Small-Cell Lung; Small Cell Lung Carcinoma

Summary: this is an open-label, multicenter, phase i study to evaluate the safety and tolerability of durvalumab ± tremelimumab in combination with chemoradiation in patients with advanced solid tumors

this study will initially treat up to approximately 300 patients with advanced solid tumors at approximately 30 sites, worldwide. the study will be composed of a dose-limiting toxicity (dlt) assessment phase (part a) and an expansion phase (part b).

Eligibility criteria:
inclusion criteria: * world health organization (who)/ecog performance status of 0 or 1 * body weight \>30 kg at enrollment and treatment assignment * at least 1 measurable lesion, not previously irradiated * no prior exposure to immune-mediated therapy (including therapeutic anticancer vaccines) * for patients with oropharyngeal hnscc hpv status has to be known exclusion criteria: * patients with simultaneous primary malignancies or bilateral tumors * active or prior documented autoimmune or inflammatory disorders * brain metastases or spinal cord compression * active infection including tuberculosis, hepatitis b, hepatitis c, or human immunodeficiency virus (hiv; positive hiv 1/2 antibodies) * has a paraneoplastic syndrome (pns) of autoimmune nature * hnscc cohort: head and neck cancer that does not include unresectable, locally advanced cancer of oral cavity, larynx, oropharynx or hypopharynx. hnscc of unknown primary are also excluded * nsclc and sclc cohort: mixed sclc and nsclc histology * sclc cohort: extensive-stage sclc

Keywords: durvalumab chemotherapy radiotherapy hnscc nsclc sclc locally-advanced limited stage first line
head to head comparison of upper airway stimulation and continuous positive airway pressure; a pilot study.

Conditions: Obstructive Sleep Apnea

Summary: to date, there has been no head to head comparison of upper airway stimulation (uas) and continuous positive airway pressure (cpap) utilizing a full night polysomnographic evaluation. with this study we aim to evaluate a pilot cohort of patients with osa treated with cpap or uas using the watchpat polysomnography system.


Eligibility criteria:
inclusion criteria: * age greater than 22 years old * history of moderate to severe osa (ahi 15-65) * uas implantation with postoperative titration and demonstrated successful use of therapy or has demonstrated the ability to tolerate cpap for greater than 4 hours per night 5 days per week. exclusion criteria: * none

Keywords: obstructive sleep apnea continuous positive airway pressure
(+) epicatechin to treat friedreich's ataxia

Conditions: Friedreich's Ataxia

Summary: this 24-week study will test the safety and effectiveness of synthetically produced (+) epicatechin in treating patients who have friedreich's ataxia, a neurological disorder.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of friedreich's ataxia (fa) by frataxin genetic testing and/or frataxin enzyme analysis * between age 10 and 50 years of age, inclusive * body weight of 25 kilograms or higher * minimum of one affected organ (cardiac or neurological) system, as evidenced by clinical signs/symptoms * disease duration ≤7 years, based on onset date of fa symptoms * has no known contraindication to gadolinium contrast such as severe allergy or glomerular filtration rate \<30 ml/min/m\^2. * has no known contraindication to non-contrast magnetic resonance imaging (mri) evaluation such as pacemaker or magnetically active metal fragments. * women of childbearing age must: * have a negative pregnancy human chorionic gonadotropin test prior to receiving study drug. * agree to use contraception for the duration of the study drug dosing, plus 1 month after completion of the study. exclusion criteria: * advanced cardiac failure, new york heart association (nyha) classification scale-class iv (advanced stage heart failure) * clinically significant comorbidities that may also lead to cardiomyopathy, for example long standing hypertension, familial cardiomyopathy. * clinically significant comorbidities that would, in the opinion of the investigators, compromise the interpretation of test results. * pregnant, breast-feeding or planning to become pregnant during study timeframe. * patients with contraindications to regadenoson, i. e. second- or third-degree atrioventricular (av) block or sinus node dysfunction. has received an investigational drug within thirty (30) days of baseline visit. * thrombocytopenia (\<125 x 10\^9/liter) or prolonged prothrombin time/partial thromboplastin time (pt/ptt) at baseline. * clinically significant hypotension (systolic blood pressure \<90) due to heart failure or other conditions.
effects of traditional chinese medicine on aecopd patients

Conditions: Pulmonary Disease, Chronic Obstructive; Acute Exacerbation; Medicine, Chinese Traditional

Summary: this is a multi-center, randomized, double-blind, controlled trial to compare the efficacy of two therapies for patients with aecopd. 378 subjects will be randomly assigned to one therapies (conventional drug, and the combination of conventional drug and tcm) for 14 days treatment. after the treatment period, subjects in two arms will be followed up for 4 weeks. the primary outcomes will include copd assessment test (cat), and secondary outcomes include treatment failure rate, treatment success rate, hospitalization time, hospital admission rate, endotracheal intubation rate, mortality and quality of life (copd-pro, sf-36).


Eligibility criteria:
inclusion criteria: * a confirmed diagnosis of moderate to very severe aecopd * age between 40 and 80 years * syndrome differentiation meets criteria of syndrome of external cold and internal fluid,syndrome of phlegm-heat congesting lung,or syndrome of phlegm-damp amassing in lung * without participations in other interventional trials in the previous one month * with the informed consent signed exclusion criteria: * pregnant and lactating women * dementia, mental disorders and reluctant partners * complicated with heart failure (nyha class iv), or serious cardiac arrhythmias, or unstable hemodynamics * current respiratory disorders other than copd (e.g., bronchiectasis, active tuberculosis, pneumothorax, pleural effusion, pulmonary thromboembolic, or neuromuscular diseases affect respiratory movement function) * combined tumor * treated outside the hospital for more than 7 days * need to carry out invasive mechanical ventilation respiratory failure * complicated with serious hepatic and renal diseases (liver cirrhosis, portal hypertension, bleeding of varicose veins, dialysis, or renal transplantation) * bedridden for various reasons * allergic to the used medicine

Keywords: chronic obstructive pulmonary disease acute exacerbation traditional chinese medicine
meta-analysis on damage control surgery in patients with non-traumatic abdominal emergencies

Conditions: Damage Control Surgery; Non-traumatic Abdominal Emergencies

Summary: this systematic review and meta-analysis aims to investigate the effect of damage-control surgery on mortality in patients with non-traumatic abdominal emergencies. literature search will be conducted using pubmed. two meta-analyses will be performed comparing (1) mortality in patients with non-trauma damage control surgery vs. non-trauma conventional surgery and (2) the observed vs. expected mortality rate in patients undergoing non-trauma damage-control surgery.

after the successful implementation in trauma patients, damage control surgery (dcs) is being increasingly used in patients with non-traumatic abdominal emergencies, too. however, non-trauma dcs is an ongoing matter of debate as the open abdomen treatment typically performed in dcs is a non-anatomical situation and associated with potentially severe side effects. to date, dcs in patients with non-traumatic abdominal emergencies has not yet been comprehensively assessed in meta-analysis. a systematic literature search will be conducted using the national library of medicine's medline database (pubmed). the search strategy will be based on the picos process. original research articles in english language addressing (1) mortality in patients undergoing non-trauma dcs vs. non-trauma conventional surgery or (2) the observed vs. expected mortality in non-trauma dcs will be included. two meta-analyses will be performed, comparing (1) mortality in patients undergoing non-trauma dcs vs. non-trauma conventional surgery and (2) the observed vs. expected mortality rate in patients undergoing non-trauma dcs based on outcome prediction scores. meta-analysis will be performed using a random-effects model. the estimated effect size for mortality will be reported as risk difference with 95% confidence intervals. sensitivity analysis will be performed by repeating the analysis in the subgroups of studies with the same study design and studies that applied the same outcome prediction score.

Eligibility criteria:
inclusion criteria: * articles on damage control surgery in patients with non-traumatic abdominal emergencies * reported in-hospital or 30-day mortality in patients undergoing non-trauma damage control surgery vs non-trauma conventional surgery or * reported observed in-hospital or 30-day mortality vs expected mortality in patients undergoing non-trauma damage control surgery * articles published from 2000 to 2020 * articles including patients older than 18 years * original research articles * articles in english language exclusion criteria: * articles describing trauma patients exclusively * articles describing pediatric patients (age below or equal to 18 years)
vitamin d increases serum levels of the soluble receptor for advanced glycation end products in women with pcos

Conditions: Polycystic Ovary Syndrome; Vitamin D Deficiency

Summary: the purpose of this study is to investigate the mechanism that explain the beneficial clinical effect of vitamin d treatment in women with pcos.

seventy-nine women with (n=22) or without (control; n=57) pcos who were diagnosed with vitamin d deficiency were enrolled. sixty-three women were treated with oral vit d3 for 8 weeks (16 with pcos and 47 controls) and 16 women were not treated (6 with pcos and 10 controls). serum 25 hydroxy-vitamin d (25 oh-d), srage, and amh concentrations were measured at baseline and after vit d3 supplementation in the treated group, and 8 weeks apart in the non-treated group. paired t-test, wilcoxon signed-rank test, and pearson correlation were used as appropriate. main outcome measure: changes in amh concentrations following vit d3 replacement.

Eligibility criteria:
inclusion criteria: * vitamin d deficient premenopausal women exclusion criteria: * pregnant women * women during their postpartum period * breastfeeding women * women taking any kind of exogenous hormones * women receiving any form of oral vitamin d replacement

Keywords: polycystic ovary syndrome vitamin d anti mullerian hormone soluble receptor for advanced glycation end products
long-term prognosis in stroke patients

Conditions: Acute Stroke

Summary: a single-center cohort of patients with acute ischemic stroke and transient ischemic attack who admitted to the severance hospital of yonsei university and their long-term outcomes.

this is a single-center cohort of consecutive patients with acute ischemic stroke and transient ischemic attack who admitted to the severance hospital of yonsei university in republic of korea. stroke recurrence, cardiovascular event, all cause mortality and cardiovascular mortality were collected through long-term follow up.

Eligibility criteria:
inclusion criteria: * all patients with acute ischemic stroke or transient ischemic attack exclusion criteria: * a patient who did not agree with enrollment of this study
comparison of microwave and radiofrequency ablation for liver

Conditions: Hepatocellular Carcinoma

Summary: according to randomized controlled trial requirement, the therapeutic effectiveness of cooled-probe microwave ablation and radiofrequency ablation on early-stage hepatocellular carcinoma is compared to find a better approach for minimally invasive thermal ablation.

according to following enrollment standard, about \>400 cases of biopsy-proved hepatocellular carcinoma(hcc) patients will be involved in the study. they will be treated with percutaneously microwave ablation (mwa) and radiofrequency ablation(rfa). the indications of patients enrolled in the study were as follows: tumor size ≤5cm in diameter, tumor number ≤3, child-pugh class a or b classification, no evidence of extrahepatic metastasis, vein or bile duct tumor embolus, and no any other anti-cancer treatment was accepted. mwa or rfa is selected for the patient according to the sequence of their visit to the hospital based on randomization number arrangement produced by spss 16.0 statistical software. the therapeutic effectiveness will be compared between two modalities.

Eligibility criteria:
inclusion criteria: * tumor size ≤5cm in diameter, * tumor number ≤3, * child-pugh class a or b classification, * no evidence of extrahepatic metastasis, * vein or bile duct tumor embolus, and * no any other anti-cancer treatment exclusion criteria: * not meeting the inclusion criteria

Keywords: microwave radiofrequency ablation
efficacy of osteopathic manipulation in chronic obstructive pulmonary disease

Conditions: Emphysema

Summary: the purpose of this study is to determine if osteopathic manipulative treatment (omt) is effective for persons with emphysema as a component of their chronic obstructive pulmonary disease.

omt sessions are designed to improve chest wall compliance and diaphragmatic function which produce an immediate positive change in pulmonary function parameters and chest wall mobility. this research project will be a significant step in expanding the understanding of the role of omt in the treatment of chronic lung disease. it is expected to yield evidence that omt is an important adjunctive modality that improves pulmonary function, increases exercise tolerance, relieves dyspnea, and improves quality of life in those with copd, and that would have widespread clinical application plus significant economic benefits. participants in this study will be randomly assigned to receive either omt or sham treatments once a week for 13 weeks. outcome measures will be obtained at baseline; immediately following the first treatment; at 4, 8, and 12 weeks after initiation of treatment; and 4 weeks after termination of the treatment. outcome variables include pulmonary function tests; quality-of-life questionnaires (including emotional functioning, fatigue, and dyspnea); and measurements of exercise tolerance and chest wall mobility.

Eligibility criteria:

Keywords: chronic obstructive pulmonary disease combination therapy, emphysema exercise human therapy evaluation rehabilitation respiratory disease /disorder therapy respiratory function biomechanics body movement diaphragm dyspnea muscle tension musculoskeletal system outcomes research quality of life somatic reflex
the role of erythropoietin in myelodysplastic syndrome

Conditions: Myelodysplastic Syndrome

Summary: the purpose of the study is to elucidate the causative molecular events responsible for the abnormal erythropoiesis in mds.

myelodysplastic syndromes are a heterogeneous group of disorders characterized by clonal expansion of hematopoietic stem cells and ineffective hematopoiesis. although all 3 cell lineages in myeloid hematopoiesis can be involved, the erythroid dysplasia and ineffective erythropoiesis of mds are usually the most severe, and often precede the development of other bone marrow lineage defects. in normal erythropoiesis, erythroid progenitors differentiate and proliferate in response to stimulation by erythropoietin (epo). epo binds to its receptor, epor, constitutively expressed at the surface of committed erythroid progenitors and induces homodimerization. this study is designed to evaluate the epor cdna sequence and its level of expression in the clonal erythroid progenitors of mds patients (in cells stratified for the same degree of erythroid maturation) to determine whether mutations in the epor may be responsible for an aberrant epo signal transduction in mds. as well as analyze intrinsic erythroid epo expression to determine whether it differs between normal controls and patients with mds and perform a microarray analysis of genes associated with epo signal transduction to determine if mds patients have abnormal expression of signal transduction proteins.

Eligibility criteria:
inclusion criteria: * adult subjects greater than 18 years of age * diagnosis of mds based on the french-american-british classification system (including secondary causes of mds) exclusion criteria: * subjects not meeting the criteria listed above

Keywords: myelodysplastic syndrome erythropoiesis ineffective hematopoiesis erythroid progenitors dyserythropoiesis
community based intervention and evaluation of the impact of social marketing of a diarrhea management pack

Conditions: Diarrhea

Summary: diarrhoeal diseases are still the major paediatric health concern worldwide, contributing for 2.5 million annual deaths in children. although the treatment of diarrhoeal illness as per the world health organization (who) guidelines brings about a considerable decline in the burden of the disease but there is still a lot to be done for this issue. zinc supplementation along with oral rehydration solution (ors) has emerged as a potent approach to treat diarrhoea. it is believed that the children having zinc deficiency are at high risk of developing infectious diseases which eventually lead to a high burden of mortality. in order to prevent and effectively manage diarrheal episodes, it is important that water purification tablets, zinc and oral rehydration salt is always available in each household. though, these products are easily available in the market separately, but are rarely available together in any household. if these products are made available in a single packet, it is likely to be an effective strategy in combating diarrheal diseases in the community.


Eligibility criteria:
inclusion criteria: * children under 5 years of age suffering from diarrhea residing in study area and having consent to participate exclusion criteria: * failure to provide consent or children having debilitating illness or requiring emergency hospital care.

Keywords: children recovery diarrhea pack social marketing
effect of transpulmonary mp on prognosis of patients with severe ards treated with vv-ecmo

Conditions: Acute Respiratory Distress Syndrome; Extracorporeal Membrane Oxygenation; Mechanical Power; Transpulmonary Mechanical Power

Summary: venovenous extracorporeal membrane oxygenation (vv-ecmo) is a salvage treatment for severe acute respiratory distress syndrome (ards). with the large-scale implementation of vv-ecmo in critical care medicine departments in china, significant progress has been made in treating severe ards. however, the patient mortality rate remains high. the pathophysiological essence of ards is an imbalance between the body's oxygen supply and demand, causing tissue and cell hypoxia, organ dysfunction, and even death. the vv-ecmo treatment process still requires mechanical ventilation assistance. however, inappropriate mechanical ventilation settings can lead to ventilator-related lung injury (vili). in recent years, mechanical power has gradually attracted everyone's attention and is considered the cause of vili. the transpulmonary mechanical power is more accurate to the energy directly performed to the lung tissue. transpulmonary mechanical energy has a specific value in judging the prognosis of mechanically ventilated patients, but its clinical significance in treating patients with vv-ecmo is unclear. this study aimed to explore the value of transpulmonary mechanical power in predicting the prognosis of patients with severe ards patients treated with vv-ecmo.


Eligibility criteria:
inclusion criteria: 1. meet the diagnostic criteria of berlin's definition for ards; 2. receiving vv-ecmo support. exclusion criteria: 1. patients had been on high pressure (ppeak \>35 cm h2o) and a high fraction of inspired oxygen (fio2\>0.8) ventilation for \>7 days; 2. patients had a contraindication to heparinization; 3. patients had an irreversible neurological injury; 4. patients had severe chronic lung disease with life expectancy \<6 months.