Kornimate/medical-research-clean huggingface dataset:
african american resilient caregivers

Conditions: Obesity, Childhood

Summary: the purpose of this pilot study is to test the feasibility of a virtual intervention to prevent child obesity and cardiovascular disease in african american families.

african american children experience a high prevalence of child obesity, increasing their subsequent risk of cardiovascular disease and diabetes. there is a lack of effective obesity prevention interventions for this population. investigators also know that african american parents and caregivers experience high levels of stress and the manifestations of stress for african american women in particular may be unique and specific. parent stress can lead to unhealthy family behaviors including less physical activity and a less healthy diet for parents and children. given this background the investigators are creating a new intervention that combines an adapted evidence-based obesity prevention program (competency based approach to community health - coach) with mindfulness-based stress reduction tailored to african american women. as an initial step the investigators will pilot the intervention in a small number of african american women to determine whether the program is feasible.

Eligibility criteria:
inclusion criteria: * identify as african american and female * have a child between the ages of 2-5 who lives with them at least 4 days per week that they care for as a parent or guardian. * feel comfortable discussing personal experiences and goals related to diet, pa, stress, parenting, etc. in front of a group of peers * access to zoom, preferably with video exclusion criteria: • non english speaking
pregabalin versus dexmedetomidine for delirium prevention after cardiac surgery

Conditions: Pregabalin; Dexmedetomidine; Delirium

Summary: the aim of this study is to compare the effect of perioperative administration of pregabalin versus dexmedetomidine on the prevalence and lasting duration of delirium in elderly patients after cardiac surgery.

pregabalin is a beta-isobutyl of gaba with chemical similarity to gabapentin . pregabalin binds to the alpha-2-delta subgroup of calcium channels, thereby reducing excitatory neurotransmitter release and preventing hyperalgesia and central sensitization . pregabalin is used as anticonvulsant but has also been used as analgesic for neuropathic pain and, lately, for postoperative pain, in an attempt to reduce opioid consumption and prevent progression to chronic pain. dexmedetomidine with its broad range of effects including easily controllable sedation, analgesia, and anxiolysis still enables the caring medical team to interact with the patient. it reduces the activity while still maintaining the reactivity of neurons in the locus coeruleus. therefore, it is an appealing alternative to traditional sedatives such as propofol and benzodiazepines.

Eligibility criteria:
inclusion criteria: * ≥ 65 years of age both genders american society of anesthesiologists (asa) physical status classification ii or iii scheduled for cardiac surgery. exclusion criteria: * patients who had history of psychiatric diseases; inability to communicate; previous history of pod; preoperative sick sinus syndrome. * allergy/sensitivity to pregabalin or dexmedetomidine. * severe bradycardia (heart rate \<50 beat per minute). * second-degree or above atrioventricular block without pacemaker. * severe hepatic or renal insufficiency. * previous cardiac or thoracic surgery. * known diagnosis of depression or other major psychiatric diseases. * cognitive impairment or inability to cooperate with the study. * renal insufficiency, and history of substance abuse.
comparison of bladder filling vs. non-filling in cesarean hysterectomy for placenta percreta

Conditions: Placenta Accreta

Summary: the placenta accreta spectrum (pas) which includes accreta, increta, and percreta represents a significant obstetric challenge. pas complicates as many as 1 per 500 pregnancies and this risk is increased with prior cesarean deliveries. antenatal diagnosis of pas allows for multidisciplinary planning and delivery before the onset of labor and/or vaginal bleeding. this approach has reduced maternal morbidity rates. including less blood loss, fewer transfusion requirements and, intraoperative urinary tract injury as well as improve fetal outcome. ultrasound evaluation is the recommended first-line modality for diagnosing pas. ultrasound features suggestive of pas include loss of the normal retroplacental clear zone, attenuation of the uterine-bladder interface, reduced retroplacental myometrial thickness, presence of intraplacental lacunar spaces, and bridging vessels between the placenta and bladder. a systematic review reported that the antenatal diagnosis of pas significantly lowered the rate of urinary tract injury (from 63% to 39%) during cesarean hysterectomies in these cases. unlike other elective cesarean hysterectomies, cesarean hysterectomy with a placenta previa increta/percreta, is more difficult. there is a greater need to both keep a margin from the vascular cervical-placental mass and simultaneously protect the urinary bladder. case series reported that bladder filling helps the surgeon to more clearly identify the planes of dissection and secure the engorged aberrant vessels, thereby reduces bladder injury. accordingly, a prospective randomized study in pregnant patients with placenta previa increta/percreta undergoing elective cesarean hysterectomy will be conducted to address this important issue.


Eligibility criteria:
inclusion criteria: * pregnant women in their third trimester (35-37 w). * placenta previa accreta spectrum identified by the ultrasound (low lying anterior or major degree anterior). * with at least one prior cesarean section. * elective cesarean hysterectomy. * evidence of gross placental invasion at the time of surgery (figo grade 3a. exclusion criteria: * patients undergoing conservative treatment. * emergency cesarean hysterectomy. * no evidence of gross placental invasion at the time of surgery. * posterior placenta.
expression and role of the jak/stat pathway in sarcoidosis granuloma cells

Conditions: Sarcoidosis; JAK-STAT Pathway Deregulation

Summary: recent studies suggest that the jak/stat signaling pathway constitutes a new step in the clinical and therapeutic progress of sarcoidosis. further investigations are necessary to identify the most suitable patients to receive treatment targeting this pathway, in particular in cases of severe sarcoidosis refractory to the various therapeutic lines.

the investigators hypothesize that the jak/stat signaling pathway constitutes a new step in the clinical and therapeutic progress of sarcoidosis, in particular in cases of severe sarcoidosis refractory to the various therapeutic lines. the main objective of this proposal is to evaluate the presence and stage of activation of the jak/stat pathway in pbmcs from inactive and active sarcoidosis patients. the second objective will be to determine the role of the jak/stat pathway in the formation and maintenance of granulomas and their association with the severity of sarcoidosis and fibrogenesis.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of mediastinopulmonary sarcoidosis made according to ats / ers / wasog criteria * or patient suspected of having mediastino-pulmonary sarcoidosis, without any other probable causal factor identified on the usual standard examination at the time of the sample with the need for diagnostic confirmation at the end of the study according to the criteria of the ats / ers / wasog * sarcoidosis with stage 1 to 4 pulmonary involvement * patients who had a chest ct scan in the 6 months preceding the sample. examination carried out as part of routine care exclusion criteria: * pregnancy. * opposition expressed to participation in the study. * patients on state medical aid.

Keywords: sarcoidosis jak/stat
effectiveness evaluation of 'the endeavour programme'

Conditions: Personality Disorder, Borderline

Summary: this study aims to evaluate the effectiveness of dialectical behaviour therapy for adults with borderline personality disorder attending community mental health services in cork, ireland. the main objective of the current study is to determine if completion of a 12 month dbt programme is associated with improved outcomes in terms of borderline symptoms, anxiety, hopelessness, suicidal behaviour, depression and quality of life. a secondary objective includes assessing client progress across multiple time-points throughout the treatment.

dialectical behaviour therapy (dbt) is noted to be an intervention with a growing evidence base which demonstrates its effectiveness in treating individuals with borderline personality disorder (bpd). nine randomised controlled trials have been completed at six independent sites. these trials have found a reduction in suicidal behaviours, intentional self-injury, depression, hopelessness and other difficulties associated with this mental health diagnosis. while the efficacy of dbt has been demonstrated through multiple rcts, few studies have examined the effectiveness of dbt in community mental health settings. in particular, no study to our knowledge has evaluated the standard 12-month dbt programme for adults with bpd in an irish community setting. "standard" dbt is delivered by a team of multidisciplinary mental health professionals, and comprises of individual therapy sessions for each patient, group skills training sessions, phone coaching and consultation meetings for the clinicians on the dbt team. the current study thus aims to evaluate the effectiveness of the standard 12-month dbt programme (the endeavour programme) in an irish community setting.

Eligibility criteria:
inclusion criteria: * meet criteria for diagnosis of either borderline personality disorder (dsm iv/v) or emotionally unstable personality disorder (icd-10) * current emotion and behavioural dysregulation * a history of self-harm behaviour * the client will have discussed the diagnosis with a member of the dbt team and will have expressed an interest in, and commitment to the 12 month programme. exclusion criteria: * an active psychosis * if the client has severe developmental delays, cognitive impairment or learning disabilities (exceeding mild range) * if a clients' substance/drug dependence, eating disorder or any other mental health issue/behaviour is at such a level that it would impede their engaging with any of the modalities of dbt
factors associated with a positive sars-cov-2 serology in contact subjects at high/moderate risk of coronavirus sars-cov-2 infection. covid-19.

Conditions: Coronavirus

Summary: in december 2019, a pneumonia due to a novel coronavirus (sars-cov-2) emerged in the city of wuhan, in china. in a few weeks, the number of confirmed cases of sars-cov-2 infection has dramatically increased, with almost 150'000 cases and more than 6'000 reported deaths on march, 16th 2020. little is known on the rate of human-to-human transmission of this new coronavirus sars-cov-2 in the community and within the hospital. depending on the country, contact subjects considered to be at high or moderate risk of sars-cov-2 are, either isolated at home for a period of time defined by the health authorities or, on the contrary, continue their professional activity on the condition that they adopt measures to prevent transmission to those around them. in most european countries, healthcare workers adopt this second option. in all cases, it is most often recommended that contact persons monitor their state of health and communicate it to the persons dedicated to this action. whether such subjects become spreaders of the virus is not known, nor is the proportion of viral spreader who will develop a symptomatic infection. in this study, we aim to evaluate the virological and clinical outcomes of subjects following a contact at high/moderate risk of sars-cov-2 acquisition, in community-subjects and/or healthcare workers. the study population is represented by all subjects who had a contact with laboratory-confirmed sars-cov-2 cases and whose contact was considered to be at high/moderate risk of sars-cov-2 acquisition. this include both children and adult subjects, subject without social security, and healthcare workers.

procedures added by the research: blood sampling for determination of the presence of sars-cov-2 type m immunoglobulins or type g immunoglobulins. blood sampling for whole exome sequencing

Eligibility criteria:
inclusion criteria: * high/moderate risk contact with a laboratory-confirmed sars-cov-2 case; * within the 14 days following the last contact with a laboratory-confirmed sars-cov-2 case; * obtaining informed consent. exclusion criteria: * subject included in the cov-contact study * subject deprived of freedom * subject under a legal protective measure

Keywords: contact subject high/moderate risk of transmission
validation study of the performance of the french version of the autism mental status examination scale as a tool for identifying autism spectrum disorder in adults

Conditions: Autism Spectrum Disorder

Summary: to improve diagnosis of autism spectrum disorder (asd), expert centers have been set up in france since 2000/2010. however, waiting times in these centers are long, mean of 19 months for adults, and more than half the people seen do not end up with an asd, even though referral by a psychiatrist is increasingly required. therefore, validated diagnostic tools for screening before referral are needed. the autism mental status exam (amse), a 8-item tool, which is quick and easy to use, appears to have excellent sensitivity (0.91) and specificity (0.93). however, this tool was only evaluated when used by experts and on a sample of 50 patients. the hypothesis of this study is that the amse, used by non-expert psychiatrists, has sufficiently good diagnostic performance (minimal sensitivity and specificity of respectively 93% and 65%) to be used in screening adults with suspected asd.

patients who contact one of the expert centers participating in the study for an asd diagnostic evaluation are first referred, as in usual care, to a non-expert psychiatrist or psychologist (from a list of professionals provided by the center and previously trained to the amse) to complete a pre-evaluation file. for the study the amse and a brief amse-filling guide is added to the file. seven days to 12 months after, patients have a 2-day (consecutive or separated by a maximum of 2 months) full asd evaluation in the expert center with a final diagnosis made by the expert multidisciplinary team according to diagnostic and statistical manual (dsm)-5 criteria for asd.

Eligibility criteria:
inclusion criteria: * patient 18 years of age or older * patient who has requested, on his or her own or through a relative, a diagnostic evaluation in an expert center for the diagnosis of asd. * patient covered by national health insurance exclusion criteria: * patient with a previous asd diagnostic evaluation * patient with a previous amse assessment * absence of informed consent (patient or his/her legal guardian) * pregnant or breast-feeding * patient deprived of freedom * non-french-speaking patient and/or parents and/or legal guardians * amse not, incorrectly or inadequately completed by non-expert psychiatrist or psychologist * patient covered by aide medicale d'etat (ame)

Keywords: autism mental status disorder adult
exploratory metabolomics study of exhaled breath in pulmonary embolism

Conditions: Pulmonary Embolism

Summary: pulmonary embolism is a frequent and recurrent pathology, especially in the elderly. it is often preventable, with high mortality and morbidity, making it a major public health issue. the clinical presentation of pulmonary embolism is non-specific and very highly variable, ranging from asymptomatic thrombus diagnosed incidentally to sudden death. the current diagnosis of pulmonary embolism is based on several diagnostic techniques, mainly non-invasive, which should be used sequentially. we propose to sample the volatile organic compounds using a device that allows them to be trapped on polymer cartridges. sampling will be performed under monitoring of respiratory pressure and a capnograph to collect alveolar and upper respiratory tract air separately without contamination of the oral cavity or sinuses. this exploratory metabolic analysis will be non-targeted (analysis of all molecules detectable without a priori). the main objective of the study is to identify specific metabolic profiles to predict the results of ventilation-perfusion pulmonary tomoscintigraphy in subjects undergoing this examination for suspected acute pulmonary embolism. secondary purposes : * to identify metabolic profiles to be used to predict, in combination with clinical probability scores, the results of ventilation-perfusion pulmonary tomoscintigraphy in subjects undergoing this examination for suspected acute pulmonary embolism.; * to correlate metabolic profiles with the topography of embolized lung territories


Eligibility criteria:
inclusion criteria: * male or female, at least 18 years old * patients with clinical suspected pulmonary embolism * patient willing and able to provide informed consent exclusion criteria: * contraindications to pulmonary ventilator-perfusion tomoscintigraphy * all types of thrombolytic or anticoagulant treatment * diagnosis of pulmonary embolism established prior to inclusion in the study * massive pulmonary embolism (systolic pressure \< 90 mm hg) * pregnancy * breastfeeding

Keywords: early diagnosis mass spectrometry volatile organic compounds metabolomics breath tests biomarkers
evaluation of a predictive score for the onset of moderate to severe alcohol withdrawal syndrome, the pawss, in a population of intensive care patients at brest university hospital

Conditions: Alcohol Withdrawal Syndrome

Summary: alcohol use disorder (aud) is a very common condition in patients admitting in icu's. brutal stop of alcohol consumption may lead to a withdrawal syndrome, wich is associated with a worse outcome for icu patients (longuer icu and hospital stays, use of mechanical ventilation, traumas). the aim of this study is to valid a score (pawss : prediction of alcohol withdrawal syndrome (aws) scale) to predict at admission mild to severe aws in icu patients population.


Eligibility criteria:
inclusion criteria: * more than 18 years old * able to answer to pawss in the first 48hours of icu stay exclusion criteria: * no alcohol consumption in the last 30 days * hospital stay of more than 5 days at icu admission * hospital stay less than 5 days in total * expected sedation time of more than 48h * patient not able to understand the pawss * no consent

Keywords: prediction intensive care unit
association between the composition of the bacterial flora of thrombi and the etiological origin of cerebral infarction treated with thrombectomy

Conditions: Patient With Symptomatic Cerebral Infarction; Patient Who Has Had a Mechanical Thrombectomy

Summary: cerebral infarction is a major health problem. the two most common causes are atherosclerosis (30 to 35%) and cardio-embolic origin (35 to 40%). however, in 25% of cases the cause is undetermined, known as cryptogenic stroke or stroke of undetermined origin. paroxysmal atrial fibrillation appears to cause a significant proportion of these cryptogenic cerebral infarctions. one of the major challenges in the management of cerebral infarctions is the prevention of recurrence. if the cause is atheromatous, treatment is based on platelet antiaggregants and the correction of cardiovascular risk factors. if the cause is atrial fibrillation, the treatment of choice is anticoagulation therapy. cryptogenic strokes are managed with antiplatelet therapy. in past studies, the thrombi responsible for cerebral infarctions have been analyzed anatomopathologically to see if the composition of the thrombi could help identify the cause of the cerebral infarction. these studies have proved to be contradictory. the composition of the bacterial flora of cerebral infarct thrombi has not yet been studied, apart from some limited data on septic emboli. in myocardial infarction, the cause of which is almost exclusively atheromatous, bacteria of the periodontal flora have been detected in thrombi of st-segment elevation infarctions. the causes of cerebral infarction are multiple. the hypotheses explored in this study are that there are differences in the composition of the bacterial flora of the thrombus depending on whether the cause is atheromatous or cardio-embolic and that the study of the composition of the thrombus could be used to identify the cardio-embolic cause in patients with cryptogenic cerebral infarction.


Eligibility criteria:
inclusion criteria: * person who has given oral consent (or a close relative or legal representative if the patient is unable to give consent) * patient with a symptomatic cerebral infarction defined according to who criteria, who has had a mechanical thrombectomy and was hospitalized at the neurovascular intensive care unit of the dijon university hospital. * 18 years or older exclusion criteria: * person not affiliated to national health insurance * person under legal protection (curatorship, guardianship) * person under court order * pregnant or breastfeeding * patient who refuses to participate in the study * patient (or family member) not reachable by telephone during follow-up.
assessment of research digest impact for minority with prostate cancer, micap phase iii study

Conditions: Prostate Carcinoma

Summary: this phase iii trial determines how well the minority prostate cancer (micap) research digest works in providing information to black men about the latest prostate cancer research. micap research digest may be an effective method to help people learn about prostate cancer.this goal of this trial is to create educational programming that helps black men make informed decisions about their prostate healthcare since black men are diagnosed with prostate cancer more than any other race or ethnicity.

primary objective: i. to develop a research dissemination program, the minority prostate cancer (micap) research digest, which will spread information about cap scientific discoveries, evidence-based interventions, and open clinical trials instantly among black males (bm). outline: participants are randomized to 1 of 2 arms. arm i: participants watch micap research digest video on study. participants complete a survey throughout the trial. arm ii: participants watch an alternative video on study. participants complete a survey throughout the trial.

Eligibility criteria:
inclusion criteria: * identify as a black male * between the ages of 35 and 70 * for virtual data collection, have access to the internet and zoom (if joining study online) * for virtual data collection, reside anywhere in the u.s. * for in-person data collection, reside in one of the nine (9) catchment areas of the mayo clinic cancer center: baker, duval, nassau, clay, st. john's, putnam, flagler, volusia and brevard exclusion criteria: * identify as a race or ethnicity that is not black * identify as female * be younger than age 35 and older than age 70 * lack access to internet and zoom (if joining study online)