Kornimate/medical-research-clean huggingface dataset:
effects of mulligan mobilization with and without dry needling in runner's knee

Conditions: Runner's Knee

Summary: the aim of this study is to determine the effects of mulligan mobilization with and without dry needling on pain, range of motion, flexibility, functional disability and muscle strength in patients with runner's knee.

runner's knee or patellofemoral pain syndrome (pfps) is a common cause of anterior knee pain in young active individuals. patellofemoral pain (pfp), or anterior knee pain (akp), is a common musculoskeletal disorder. it involves dysfunction in mechanical forces between the patella and the femur. the worldwide pfp prevalence has been reported as 15-45% of population. females are at two times higher risk of pfp than males, especially young active females. the aim of this study is to determine the effects of mulligan mobilization with and without dry needling in runner's knee in a randomized clinical trial. the study will be randomized clinical trial. the study will be conducted at johar pain relief center, lahore. the study will be completed within eight months after synopsis approval from ethical committee of riphah college of rehabilitation and allied health sciences. sample size will be 40 (20 in each group). non-probability convenience sampling technique will be used to recruit the runner's knee patients in the study and then they will be divided into two groups by simple randomization through sealed opaque envelope. mulligan mobilization with dry needling will be given to group a. mulligan mobilization without dry needling will be given to group b. outcome measures will be pain, knee range of motion, flexibility, functional disability and muscle strength measured through numeric pain rating scale (nprs), goniometer, kujala patellofemoral scale and modified sphygmomanometer test (mst) respectively. data will be analyzed by spss version 25.

Eligibility criteria:
inclusion criteria: * patients of both genders. * individuals aged 20-45 years with a clinical diagnosis of runner's knee. * participants experiencing retropatellar or anterior knee pain during at least two activities such as ascending and descending stairs, squatting, kneeling, or prolonged sitting, jumping or running. * pain scoring rate on numeric pain rating scale (nprs) ≥ 3 during at least two activities. * duration lasting longer than two months. exclusion criteria: * patients with a history of meniscus tears, bursitis, patellar tendon injury, ligamentous injury, joint degeneration, patellofemoral dislocation and / or recurrent subluxation. * participants with a history of arthritis. * individuals with a history of lower extremity surgery. * patients having knee pain referred from hip, lumbar spine and ankle joints. * any systemic disease and/or connective tissue disorders, or lumbosacral nerve root compression. * patients taking any pain medications. * individuals who previously received acupuncture therapy, injection, or dry needling technique for knee extensor muscle in last six months.

Keywords: dry needling pain range of motion
balance and strength exercise in knee osteoarthritis patients

Conditions: Knee Osteoarthritis

Summary: the aim of this study is to assess the effect of balance exercise on dynamic balance and physical function in 80 patients with different grades of primary knee osteoarthritis (koa).

the study will include 80 patients with primary knee osteoarthritis divided into 4 groups according to the kellgren and lawrence grading scale (kl): group 1: 20 patients with grade i koa group 2: 20 patients with grade ii koa group 3: 20 patients with grade iii koa group 4: 20 patients with grade iv koa * patients will undergo pre-exercise and post- exercise assessment with: 1. western ontario and mcmaster university osteoarthritis index (womac) 2. modified stare excursion balance test 3. timed up and go test * exercise program includes: 1. lower extremity kinesthesia and balance exercise program 2. strength exercise program

Eligibility criteria:
inclusion criteria: * patients with primary knee osteoarthritis according to the eular recommendations 2010. * patients can complete at least stage 1 of balance and exercise program (minimum of 2 weeks) exclusion criteria: * patients that cannot complete at least stage 1 of balance and exercise program * patients with medical conditions affecting postural balance including visual, inner ear and neurological problems. * patients with lower limb joint or bony problems other than primary knee osteoarthritis . * patients with secondary koa. * patients who received intra- articular joint injection in 1 or both knees in the past 90 days.
translating adoption of improved varieties into nutritional impact

Conditions: Malnutrition

Summary: the purposes of this study are (1) to determine whether child nutrition-focused adoption encouragement messages focused on quality protein maize (qpm) and the availability of small quantities of qpm seed can be effective at increasing qpm adoption and health outcomes for young children, and (2) to determine whether consumption encouragement messages and techniques (e.g., containers for earmarking) can be effective at increasing qpm targeting to and health outcomes for young children.


Eligibility criteria:
inclusion criteria: households with at least one child in the 6-35 month age range in august 2015, who had at least one household member attend a field day demonstrating quality protein maize, and who provided informed consent for participation and data collection were eligible for inclusion. exclusion criteria: households in the study areas that do not have a member who attends a field day demonstrating quality protein maize or who do not have a child in the appropriate age range are excluded from the study. furthermore, households where the mother or children did not intend on staying in the region for the study duration (until the completion of the endline survey) were excluded from the study. finally, we excluded participants who do not have access to land for crop cultivation.

Keywords: biomarkers child nutrition sciences economics, behavioral
tandem vr: synchronized nature-based experiences in virtual reality for hospice patients and their caregivers

Conditions: Hospice; End of Life; Palliative Care; Pain; Anxiety; Fear of Death

Summary: background: nature-based virtual reality (vr) and other outdoor experiences in head-mounted displays (hmds) offer powerful, non-pharmacological tools for hospice teams to help patients undergoing end-of-life (eol) transitions. however, the psychological distress of the patient-caregiver dyad is interconnected and highlights the interdependence and responsiveness to distress as a unit. hospice care services and healthcare need strategies to help patients and informal caregivers with eol transitions.

methods: this study uses a synchronized tandem vr approach where patient- caregiver dyads experience immersive nature-based and other outdoor vr content. this mixed methods study will recruit 20 patient-caregiver dyads (n = 40) enrolled in home hospice services nearing the end-of-life. dyads will experience a personalized nature-based or other outdoor vr experience lasting 5-15 minutes. self-reported questionnaires and semi-structured interviews will be collected before and after the vr intervention to identify the impacts of personalized nature-based and other outdoor tandem vr experiences on the qol, pain, and fear of death in patient-caregiver dyads enrolled with hospice services. additionally, this protocol will determine the acceptance of personalized nature-based and other outdoor tandem vr experiences by dyads as a non-pharmacological modality for addressing patient and caregiver needs. acceptance was quantified by the number of dyads accepting or declining the vr experience during recruitment. discussion: using personalized, nature-based and other outdoor vr experiences, the patient-caregiver dyads can simultaneously engage in an immersive encounter to help alleviate symptoms associated with declining health and eol phases for the patient and the often overburdened caregiver. this protocol focuses on meeting the need for person- and caregiver-centered, non-pharmacological interventions to reduce physical, psychological, and spiritual distress.

Eligibility criteria:
inclusion criteria: * english speaking * projected life expectancy of \<6 months (established by hospice experts) * cognitively intact (has sufficient judgment, planning, organization, and self-control) exclusion criteria: * having a cognitive impairment that affects protocol participation. this will be done with the assistance of research recruiters to assess eligibility. * have a condition that interferes with vr usage, including but not limited to seizures, facial injury precluding safe placement of headset * have a prognosis of hours or actively dying at the time enrollment * patients with motion sickness * patients with claustrophobia * patients with visual and hearing impairment * patients with inability to speak english

Keywords: hospice palliative care virtual reality vr quality of life personalized nature tandem
clinical outcomes after bowel resection in patients receiving alvimopan versus patients not receiving alvimopan in the premier perspective database

Conditions: Ileus

Summary: alvimopan is the first and currently the only fda-approved therapy for acceleration of the time to upper and lower gastrointestinal (gi) recovery following partial large or small bowel resection surgery with primary anastomosis. the primary objective of this retrospective observational trial is to assess postoperative morbidity and mortality as reported during the index hospitalization for bowel resection and 15/30-day readmissions of alvimopan vs. non-alvimopan matched patients in the combined premier/care science database(a large medical claims database).


Eligibility criteria:
inclusion criteria: * ≥ 18 years at discharge * medical claim with an icd-9-cm procedure code for a primary procedure (identified at position 1 or 2 involving large or small segmental bowel resection with primary anastomosis * discharged within the study dates * surgery at a participating premier/care sciences hospital exclusion criteria: * had a diverting ostomy without a primary anastomosis during the index hospitalization * had a trauma diagnosis * had bowel resections performed on more than 1 day during index hospitalization (this includes cases where a bowel resection and intestinal anastomosis were performed on different days during the index hospitalization) * had an excluded non-bowel resection surgical code (i.e., code for a major non-br surgical procedure \[eg., nephroureterectomy, total joint replacement\] in position 1 or 2

Keywords: gi recovery after bowel resection morbidity after bowel resection mortality readmission length of stay
storytelling video intervention for depressed primary care patients - open trial

Conditions: Major Depressive Disorder

Summary: the overall aim of this program of research is to develop a collaborative narrative intervention for patients with depression being treated in primary care. the purpose of the proposed project is to establish the feasibility, acceptability, and preliminary effects of our newly developed narrative intervention on depression. to achieve the specific aims, the investigators will conduct an open trial to further develop and refine the intervention (n = 10).

the public health impact of existing treatments for major depression is limited by our ability to disseminate those treatments. there is a particular need to find innovative ways to disseminate key principles of empirically supported psychotherapy in primary care settings. narrative communication is an alternative way to disseminate psychotherapy behavior change principles. narrative communication refers to "storytelling" -real people talking about their struggles and successful ways of coping. an advantage of narrative communication is that it can be easily distributed (by video) and may reach people who do not have access to other technologies or who experience barriers to traditional psychotherapy. we propose that key principles of a type of cognitive-behavioral therapy (acceptance and commitment therapy, or act) can be readily disseminated through a video storytelling intervention. act is an empirically supported therapy for depression. together with a video production firm with a record of working in healthcare and developing documentary-style videos, we will produce a storytelling video intervention (stvi). our aim is to conduct a small open trial (n = 10) of antidepressant medication treatment as usual + stvi. assessments will occur at baseline and 4 weeks (post-treatment). we will examine the feasibility and acceptability of stvi (e.g., uptake and completion of stvi, engagement with videos, and understanding of key act principles) and of this research design. we will examine treatment effects (within relevant confidence intervals) on outcomes (e.g., depression severity). we will examine change in potential mechanisms, i.e., act-consistent coping strategies derived from key act principles.

Eligibility criteria:
inclusion criteria: 1. meets dsm-5 criteria for current or lifetime major depressive disorder. 2. no lifetime diagnosis of bipolar disorder, schizophrenia, or chronic psychotic condition. 3. no current hazardous illicit drug or alcohol use. 4. no suicidal ideation or behavior requiring immediate attention. 5. depression symptom severity: a quick inventory of depressive symptoms (qids) score \>11. 6. taking an antidepressant medication for at least 6 weeks; prescribed by their primary care provider. 7. not in psychotherapy during the study period. 8. have a pcp at our enrollment site. 9. if pregnant, less than 24 weeks gestation. 10. english speaking. 11. aged 18 or older.

Keywords: narrative communication depression primary care treatment development
time-restricted eating and high intensity interval training among women

Conditions: Obesity; Endocrine

Summary: this project will determine the independent and combined effects of high intensity interval training and time-restricted eating on blood sugar regulation among women in reproductive-age who have overweight or obesity. the intervention period will be seven weeks. before and after the intervention, blood sugar regulation, body composition and physical fitness will be measured and compared between groups who are doing either high intensity interval training, time-restricted eating, both high intensity interval training and time-restricted eating, or who are in a control group. physical activity, sleep quality, continuous glucose monitoring, adherence to the interventions and hunger/satiety will also be measured.

in a follow-up study, we will invite randomized participants to come in for new assessments of physical fitness, body composition and fasting blood samples, and they will be asked to complete questionnaires about adherence to the interventions two years after intervention-end. the first participants will come in to the laboratory for the two-year follow up in november 2021.

Eligibility criteria:
inclusion criteria: * body mass index ≥ 27 kg/cm2, * able to walk on a treadmill or ride a bike for at least 60 min. exclusion criteria: * pregnancy, lactation within 24 weeks of study commencement * known cardiovascular disease * type 1 or 2 diabetes * currently taking hypertension or glucose- or lipid-lowering medication * habitual eating window \< 12 hours * performing high intensity training more than once a week * body mass variations \> 4 kg three months prior to study commencement * shift work that includes night shifts.

Keywords: exercise diet overweight glycaemic control fitness body composition
distinct alterations in gut microbiota composition among women of reproductive age with elevated homocysteine levels.

Conditions: Recurrent Miscarriage

Summary: the goal of this observational study is to test the alterations of gut microbiota composition among women of reproductive age with elevated homocysteine levels. the main question it aims to answer is: • the relationship between gut microbiota composition and recurrent abortion. participants will provide their stool samples to be detected the composition of gut microbiota. . researchers will compare women of reproductive age with normal homocysteine levels to see if any bacteria were involved in recurrent miscarriages.


Eligibility criteria:
inclusion criteria: * no recent antibiotic treatment exclusion criteria: * recently received antibiotics
impact of a training program and organization on the management of stroke in the acute phase (avc-ii)

Conditions: Acute Ischemic Stroke

Summary: acute stroke management represents a true medical emergency that requires prompt diagnosis and urgent treatment. in a previous exhaustive cohort study conducted in the rhône region, france (avc69) (porthault et al. 2013) the investigators observed that only a small percentage of patients could access to thrombolysis in time. in this cohort of 1306 patients treated in one of the emergency department of the rhone region for a suspected stroke, 84% of patients reached hospital through an emergency department instead of going directly to a stroke unit. among those patients, only 2% were finally thrombolysed. a significant part of patients arrived in the emergency department too late to be thrombolysed. however, among the subset of ischemic stroke patients who reach emergency department less than 3 hours after symptoms onset, and who had no clinical or radiological exclusion criteria for thrombolysis, only 15 % were thrombolysed. the hypothesis was that an intervention designed to improve ed professional's knowledge and skills and to develop together efficient clinical pathway would decrease door-to imaging time and consequently door-to needle time and eventually improve overall thrombolysis rate. the investigators have conducted a cluster randomized controlled stepped wedge trial. all adult patients with suspected stroke arriving in one of the participating ed were included in the study along five successive four-month periods. the program featured: development of written materials (booklets) and video (film), and one day session of standardized training for trainers, at least one nurse and one physician of all eds, with formal presentation to improve knowledge, and simulation to improve skills for using the "fast" tool (nurses) and the "nihss" score (ed physicians). additionally, a clinical pathway was developed to adapt general evidence based guidelines to the local organization. the primary outcome is the door-to imaging time.


Eligibility criteria:
inclusion criteria: * all adult patients admitted to one of the participating ed for suspected ischemic stroke less than or equal to 4 hours from symptoms onset were included in the study. exclusion criteria: * age below 18 * admission to the ed more than 4 hours after symptoms onset or unknown time of first symptoms

Keywords: acute ischemic stroke stepped-wedge interactive training implementation emergency department
randomized controlled trial using patient reported outcomes and care managers to improve hiv medication adherence in routine clinical care

Conditions: HIV

Summary: among hiv-infected patients, adherence to antiretroviral medications is one of the most important determinants of clinical outcomes including viral suppression, viral resistance, disease progression, and death. unfortunately poor adherence among patients with hiv is very common, mean levels of adherence in clinical cohorts are 60-75% or less. alcohol, drug abuse, and mental illness particularly depression symptoms are key predictors of poor adherence, common among hiv-infected individuals, and important to identify and treat among nonadherent patients. this study will examine the ability of patient reported outcomes (pros) and a targeted care management approach to improve clinical outcomes with a randomized controlled trial (rct) in routine clinical care of patients with hiv. the investigators will determine whether healthcare delivery team notification of pros including antiretroviral medication adherence and barriers of adherence such as depression and substance abuse along with tailored intervention recommendations and targeted care management leads to improvement in both process and clinical outcomes including patient-reported outcomes. the investigators will examine process outcomes such as use of clinic support services, and patient outcomes such as improvement in adherence, substance use, depression, and hiv-1 rna levels.


Eligibility criteria:
inclusion criteria: * hiv-infected individuals * english speaking * 18 years of age or older * access to either a home phone or cell phone at enrollment * in care at least 6 months. * self-reported inadequate adherence based on routine clinic assessment exclusion criteria: * do not speak english * not receiving antiretroviral medications

Keywords: adherence depression care management stepped care hiv patient reported outcomes antiretroviral medication adherence
feasibility study of a new immunoglobulin e (ige) assay method

Conditions: Allergy and Immunology

Summary: the main objective is to study the feasibility of a new specific ige assay using a bioluminescence technique in a pediatric and adult allergic population. for this, we will collect blood, and urine during a blood test scheduled for the follow-up of the patient.

allergy is a raising public health problem. specific ige assays are useful tools to investigate the physiopathology of allergies. this method is achieved mainly by the immunocap enzyme immunoassay technique. this is an expensive test that requires a significant amount of blood. this is a limitation particularly in children. the time to get the results is long and a second consultation has to be scheduled in order to communicate the results to the patients. the main objective of this study is to assess the feasibility of a new specific ige assay, named lulisa, using a bioluminescence technique in urine and blood samples from pediatric and adult allergic population. this technique was recently published for the quantification of ige against two peanut allergens and needs to be extended for the detection of other major allergens. a secondary objective is the evaluation of the time needed to obtain results.

Eligibility criteria:
inclusion criteria: * males or females 6 months' old or older * sensitization or allergy towards a trophallergen, an aeroallergen, hymenoptera venom or drug proven by: * positive skin test (s) * and / or ige specific (s)\> 0.1 kua / l * and / or anamnesis in favor of an allergic reaction of mediated ige * social coverage up to date exclusion criteria: * children younger than 6 months'old * children's weight less than 10 kg * pregnant or breastfeeding women * patients with cystic fibrosis * patients with dysimmune or autoimmune pathology * anamnesis in favor of a delayed allergy or a contact allergy.

Keywords: ige assay food allergy/ hypersensitivity respiratory allergy/ hypersensitivity hymenopter allergy/ hypersensitivity