Kornimate/medical-research-clean huggingface dataset:
mindfulness-based interventions targeting first-generation college student retention in rural environments

Conditions: Depression; Anxiety

Summary: the goal of this randomized control group is to learn about effective treatments for college students experiencing anxiety and/or depression. the main questions this clinical trial aims to answer are: 1) can mindfulness-based treatments increase retention rates among first-generation college students? 1) can mindfulness-based treatments decrease anxiety and/or depression among first-generation college students? participants will be randomly assigned to one of two intervention groups: mindfulness meditation or psychoeducation. researchers will compare outcomes from each group to explore treatment differences.

method/design. this study will be a remote, two-arm, randomized, controlled trial. first-generation college students (n=53) will be randomized to either mindfulness meditation (mm), or psychoeducation (pe). the mindfulness meditation will be a loving kindness meditation adapted to apply to college communities. each intervention will be applied for 30 minutes, once a week, for four weeks through a remote platform. the mm is adapted through a validated brief mindfulness-based intervention framework (zeidan, 2010). the primary outcome, intention to persist in college, and the secondary outcomes, depression and anxiety, will be assessed by a blinded researcher at baseline, one-week post treatment, and one-month follow-up. change in sense of connection during the final treatment session, measured with a comprehensive battery of self-report indices, will be the primary therapeutic mechanism. aims and objectives. the proposed project's central hypothesis is that mm will increase first-generation students' intention to persist in college and increase their emotional well-being by increasing their sense of belonging in their college community. aim 1. examine mm's effect on first-generation college students' intention to persist in college (primary outcome) over time. hypothesis: participants who are randomized into the mm group will report higher intention to persist scores from baseline to one-month follow-up than those who are randomized to pe. aim 2. exploratory. determine mm's effect on anxiety and depression scores (co-secondary outcomes) over time. hypothesis: mm will decrease depression and anxiety relative to pe from baseline to one-month follow-up. aim 3: exploratory. investigate whether transcendent states during the final mm session predicts students' intention to persist scores. hypothesis: the effect of mm on students' intention to persist will be mediated by self-transcendent experience during mindfulness practice.

Eligibility criteria:
inclusion criteria: 18 years or older. currently enrolled in four-year college in the united states. first-generation college student. access to wifi and a computer/smartphone/tablet. english speaking. exclusion criteria: not currently enrolled in a four-year college. not a first-generation college student. non-english speaker. not able to utilize wifi or computer/tablet/smartphone.
national collaborative to improve care of children with complex congenital heart disease

Conditions: Hypoplastic Left Heart Syndrome (HLHS)

Summary: the purpose of this initiative is to improve care and outcomes for infants with hlhs by expanding the npc-qic national registry to gather clinical care process, outcome, and developmental data on infants with hlhs between diagnosis and 12 months of age, by improving the use of standards into everyday practice across pediatric cardiology centers, and by engaging parents as partners in the process.

the purpose of this initiative is to improve care and outcomes for infants with hlhs by: 1) expanding the established npc-qic national registry to gather clinical care process, outcome, and developmental data on infants with hlhs between diagnosis and 12 months of age, 2) improving implementation of consensus standards, tested by teams, into everyday practice across pediatric cardiology centers, and 3) engaging parents as partners in improving care and outcomes.

Eligibility criteria:
inclusion criteria: * fetuses or newborns diagnosed with hlhs or other univentricular condition * intended to undergo norwood procedure exclusion criteria: * none
blood leukocyte profiling in eosinophilic type 2 asthma: influence of systemic il-5 targeting

Conditions: Asthma

Summary: the goal of this exploratory and observational prospective study is to study the composition and phenotypes of blood leukocytes collected from asthmatic patients before and after instantiated treatment with the interleukin-5 neutralizing antibody mepolizumab. comparisons will be made to leukocyte profiles in patients already on mepolizumab treatment, asthma patients without any biological treatment, and non-diseased control subjects.

asthma is a chronic inflammatory and obstructive condition affecting the airways. the disease is commonly associated with elevated blood eosinophils and tissue eosinophilia. many aspects of the pathophysiological mechanisms and clinical symptoms are controlled by conventional therapies such as inhaled corticosteroids (ics) and long acting β2 agonists. however, some patients remain clinically uncontrolled and need additional treatment such as direct targeting of eosinophil granulocytes by neutralizing the eosinophil-promoting cytokine interleukin 5 (il5). mepolizumab is a humanized monoclonal il-5 neutralizing antibody that is used to treat patients with moderate-severe eosinophilic asthma. while a marked reduction of eosinophils is a key effect of mepolizumab, the exact mechanism of action is unknown. apart from basophils, that also express the receptor for il-5, other leukocytes are likely to be indirectly affected by the suppressed eosinophilia. in addition, it is largely unknown to what extent the few eosinophils remaining after anti-il5 treatment differ from pre-treatment eosinophils. the present study is a prospective observational asthma study that aims to use microscopic analysis to investigate the composition and subtypes of blood leukocytes collected before and after instantiated mepolizumab treatment. comparisons are made to patients already on mepolizumab treatment, asthma patients without any biological treatment, and non-diseased control subjects.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of asthma (the asthma patient arms) * eligible for mepolizumab treatment as per the country-specific prescribing information (the arms with mepolizumab) exclusion criteria: * any diagnosed infection (all arms) * previous history of lung disease, chronic inflammatory condition, atopy, or cardiovascular disease. diagnosed or perceived infection within 3 weeks prior to blood sampling (healthy non-asthma control subjects)
community salt testing and relation of iodine intake to visual information processing of ethiopian infants

Conditions: Iodine Deficiency Goiter; Infant Development

Summary: this study evaluated efficacy of iodized salt for mothers and their six-month-old infants' thyroid hormones and visual information processing. half of the participants received 450 g iodized salt for the household each week, while the other half received 225 ug iodine daily as a potassium iodide capsule.

iodine is essential for the synthesis of thyroid hormones, and thyroid hormones regulate the metabolic processes of most cells and play important roles in human growth and development. iodine deficiency disorders can have serious consequences on brain and physical development. in neonates iodine deficiency and hence insufficient supply of thyroid hormones could cause neonatal goiter, neonatal hypothyroidism, and endemic mental retardation. iodine deficiency disorders can be prevented and controlled by providing iodine and iodine can be provided in different ways. however, the united nations children's fund and the world health organization jointly recommended salt iodization where iodized salt is accessible. iodized salt is a safe, cost effective and sustainable strategy to ensure sufficient intake of iodine by all individuals and to improve maternal and infant health. however, although the effect of iodine on human health is well established efficacy of iodized salt has not been studied.

Eligibility criteria:
inclusion criteria: * the women must be lactating and must have an infant less than or equal to one week old. * mothers had to volunteer to participate in the study. exclusion criteria: * any hyperthyroidism symptoms manifested by nervousness, anxiety, heart palpitations, or rapid pulse. * if infants had fever, cough or severe (\>3/day) diarrhea * any allergic reaction such as acne, weakness, or foul breath
additional effects of dry needling with conventional physical therapy versus conventional physical therapy in plantar fasciitis: a randomized control trial

Conditions: Plantar Fascitis

Summary: this study is a randomized controlled trial and the purpose of this study is to determine the effects of dry needling with conventional physical therapy versus conventional physical therapy on gait parameters in plantar fasciitis: a randomized control trial.

the purpose of this study is to determine the effects of dry needling with conventional physical therapy versus conventional physical therapy on gait parameters in plantar fasciitis outcomes variables of pain , ankle rom, gait parameters and activities of daily living in adults (age : 40-60 years ) will be determined using: 1. numeric pain rating scale 2. goniometer 3. 30 meter walk test 4. foot and ankle ability measure faam data will be before and after the intervention protocol for each participant. data collection procedure: participants of interest would be approached and explained about the research. informed written consent will be taken. pre and post intervention scores will be recorded.

Eligibility criteria:
inclusion criteria: * age 40-60 years * both genders * plantar heel pain for longer than 3 months * pain score at least or less than 8 on the numeric pain (nprs) * clinical diagnosis of unilateral pf in accordance with the clinical practice guidelines from the orthopaedic section of the american physical therapy association apta: * plantar medial heel pain: most noticeable with initial steps after a period of inactivity but also worse following prolonged weight bearing * heel pain precipitated by a recent increase in weight bearing activity * pain with palpation of the proximal insertion of the plantar fascia * positive windlass test * negative tarsal tunnel tests * limited active and passive talocrural joint dorsiflexion range of motion * abnormal foot posture index score * high body mass index in nonathletic individuals exclusion criteria: * positive ankle drawer tests * pregnant womwn, mental illness, immune suppressed patients, thrombocytopenia, anti-coagulant therapy patients and post-mastectomy * congenital abnormalities of foot * a history of surgery to the ankle, foot or lower leg * other causes of heel pain (including tarsal tunnel syndrome, calcaneal fracture, ankle or foot instability, arthritis of the foot or ankle, rheumatoid arthritis, spondyloarthropathy, gout,peripheral neuropathy ) * presented with 2 or more positive neurologic signs consistent with nerve root compression
etiology of uncomplicated fever in children <5 in rural zanzibar

Conditions: Fever; Infectious Disease

Summary: the purpose of this study is to study the most common etiologies of uncomplicated fever diseases among children under five years of age in rural zanzibar.

during the last 6 years zanzibar has undergone a dramatic change in malaria epidemiology and burden of disease, with a marked decline of plasmodium falciparum malaria among febrile children from approximately 30% to 1% or below and a reduction of crude child mortality of 50%. millions of children in africa die of neonatal disorders, acute respiratory tract infections (ari), diarrhea, malaria, measles, hiv and malnutrition. a majority of these illnesses are also a common cause of febrile illness in out-patient departments. however, most of the few fever studies made in africa are hospital based very few studies on etiology of childhood febrile disease have been conducted on first level health facilities in the least developed countries in africa. this study will therefore focus on children between 2 months to 5 years of age that have been diagnosed with a negative rapid diagnostic test (rdt) for malaria and their causes of fever at the first referral level in out-patient clinics in zanzibar.

Eligibility criteria:
inclusion criteria: * patients between 2-59 months of age with confirmed fever, with a measured axillary temperature of ≥37.5˚c, or history of fever within the preceding 24 hours. * presenting at the health facility from 8.00 to 16.00 monday to friday. * informed consent. * able and willing to complete stipulated follow-up. exclusion criteria: * decision by the clinician to refer the patient to another health facility than the phcc where the study is conducted. * symptoms/ signs of severe disease that requires immediate referral from the phcc as defined by the clinicians. these symptoms/signs of severe disease are according to the imci guidelines.

Keywords: fever etiology children under five years of age imci
prevalence of non-adherence to medication among patients on chronic hemodialysis

Conditions: Medication Adherence; End Stage Renal Failure on Dialysis

Summary: background: non-adherence to medication among patients on chronic hemodialysis compromises treatment effects and results in increased morbidity, mortality and extensive costs to the healthcare system. to our knowledge, no studies have investigated the prevalence of non-adherence among danish hemodialysis patients using a validated measure of non-adherence. aim: the primary aim of this study was to investigate the prevalence of non-adherence among danish patients on chronic hemodialysis measured by self-report. our second aim was to explore patients' beliefs about medicines and potential associations between beliefs and non-adherence to medication. our third aim was to explore the prevalence and severity of physical and emotional symptoms and potential associations with non-adherence to medication. design: a multi-centre cross-sectional study according to the strobe statement will be conducted from may 2019 - april 2021. the study will take place in the outpatient hemodialysis centres at three large university hospitals in the capital region of denmark.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of end stage kidney disease * must have received hemodialysis treatment ≥3 month at a hospital-based outpatient hemodialysis centre * must be able to understand and speak danish exclusion criteria: * cognitive impairment * no current medication prescriptions
gene expression correlates of post-traumatic stress disorder (ptsd) symptom change after eft (emotional freedom techniques)

Conditions: Stress Disorders, Post-Traumatic

Summary: the purpose of the study is to measure the change in psychological symptoms and gene expression in war veterans after a series of 10 eft coaching sessions. outcome studies have shown statistically significant reductions in depression, anxiety, and ptsd in veterans after eft, and this study extends earlier research using biological sampling. eft is a form of energy psychology (ep) that is sometimes referred to as "emotional acupuncture." it involves self-stimulation of 14 acupuncture points at the end of meridians with the fingertips, while recalling an emotional event such as a combat trauma. it is typically effective in 6 to 15 coaching sessions, making it an efficient clinical technique for reducing affect.

there is peer-reviewed published experimental evidence showing that (a) acupuncture reduces the fear response in the brain, especially the limbic system, and most particularly the amygdala; that (b) tapping or rubbing acupuncture points (acupressure) can be as effective as needling them; that (c) efts use of such acupressure is efficacious in reducing anxiety, ptsd and other mood disorders; that (d) eft reliably reduces emotional intensity associated with traumatic memories, is safe and low-risk; that (e) all ep studies that included a long-term follow-up show that patient gains are maintained over time; that (f) the psychological questionnaires used in this study are validated and safe; and that for all these reasons (g) ep is a treatment of choice among therapists when dealing with the traumatic memories of clients. this study extends these findings by noting changes in gene expression associated with the remission of ptsd symptoms.

Eligibility criteria:
inclusion criteria: * military service * the ability to follow instructions, complete written forms, understand english, and provide informed consent. subjects are required to be literate and understand english. * remaining under the care of a primary care provider such as a va hospital throughout the entire period of the study * between 18 and 80 years old. no children will be research subjects in this study. exclusion criteria: * a current or past physical or psychiatric disorder that would preclude their being able to respond to the psychosocial measures adequately, or to give blood safely (i.e. cognitive dysfunction, psychosis, or any blood or bleeding disorder) * regularly work a night or graveyard shift (to avoid effects of alterations in circadian rhythm) * inability to come into the san francisco laboratory for an afternoon for testing * immunomodulatory disorders (e.g. aids, rheumatoid arthritis, multiple sclerosis, lupus) or cancer history * aggressive chronic periodontitis * antibiotics within the last 3 months prior to the recruitment date * a score of more than 4 on questions 34 and 35 of the sa-45: having urges to beat, injure, or harm someone having urges to break or smash things
boston scientific offroad™ re-entry catheter system for subintimal recanalization of chronic total occlusions in femoropopliteal arteries

Conditions: Chronic Total Occlusion

Summary: study of the offroad™ re-entry catheter system for subintimal recanalization of chronic total occlusions in native femoropopliteal arteries.


Eligibility criteria:
inclusion criteria: * claudication or critical limb ischemia (rutherford category 2-5) * documented de novo or re-occluded chronic total occlusion (cto) (99-100% stenosed) lesion in native femoropopliteal artery * target vessel occlusion length is ≥ 1 cm and ≤ 30 cm * minimum reference vessel diameter is 4 mm exclusion criteria: * contraindication to an endovascular procedure * previous stent placement in the target vessel * prior surgery of the superficial femoral artery (sfa) in the target limb to treat atherosclerotic disease * platelet count \ 600,000 mm3 * renal insufficiency with a serum creatinine \>2.3 mg/dl * history of major amputation (ankle level or above) in the same limb as the target lesion * current participation in another drug or device clinical study
heart failure (hf) assessment with b-type natriuretic peptide (bnp) in the home

Conditions: Heart Failure

Summary: the habit clinical study is being performed to determine the benefit and optimal frequency for at home testing of b-type natriuretic peptide (bnp) for heart failure patients following hospitalization from decompensation. subjects will be enrolled following hospitalization for decompensated heart failure. enrolled subjects will be trained on the use of the triage touch meter for fingerstick bnp assessment; these subjects will then test their bnp levels daily using the triage touch product for approximately 60 days.

this is a multi-center, single-arm double-blinded prospective clinical study to determine the optimal frequency of home b-type natriuretic peptide (bnp) testing and the changes in bnp concentrations that correlate with clinical heart failure (hf) decompensation and related adverse clinical outcomes in at-risk hf patients. approximately 200 subjects will be enrolled.

Eligibility criteria:
inclusion criteria: * adults (18 years of age or older); * admitted to the hospital or observation unit with a diagnosis of decompensated hf for which treatment will be administered; * blood bnp level measurement \> 400 pg/ml documented during admission; if nt-probnp is used routinely in the laboratory at a clinical site rather than bnp, then blood nt-probnp level measurement \> 1,600 pg/ml documented during admission. * successfully trained on how to perform a fingerstick and to use the triage touch. * either the subject or their care provider is fluent in reading and writing english exclusion criteria: * unwilling or unable to provide written informed consent; * acute coronary syndrome (acs) that is concomitant with the diagnosis of decompensated hf and for which treatment will be provided. a history of acs is not reason for exclusion if it is not concomitant with the present decompensated hf for which admission is being made. small elevations in cardiac troponin that are considered by the treating physician to be associated with myocardial injury due to the acute decompensated hf and not due to a concomitant acs or myocardial infarction are not a basis for exclusion. * previous cardiac transplantation - or cardiac transplantation anticipated within 3 months; * current or planned use of a left ventricular assist device (lvad), use of outpatient intravenous inotropic hf therapy, major surgical procedure or percutaneous coronary intervention within 3 months; * life expectancy less than 3 months due to causes other than hf or cardiovascular disease (e.g., cancer); * end stage renal disease; * prisoner or other institutionalized or vulnerable individual; * residence in regions where either transmission of triage touch data or a home visit on day 5 is not possible. * dementia, tremors or other impediments to performing daily home bnp testing via fingerstick. * deemed by the investigator not to be likely to comply with study-mandated procedures or instructions.

Keywords: heart failure bnp b-type natriuretic peptide home testing
a clinical study of regorafenib in participants who have been treated in previous bayer-sponsored regorafenib studies that have been completed

Conditions: Solid Cancer

Summary: the purpose of this study is to enable participants, currently receiving regorafenib in a bayer-sponsored clinical trial, to continue treatment after their respective study has been closed. patients participating in this study will be observed to collect information on how safe the drugs are and how this treatment is tolerated.

the primary objectives of the study are a) to allow patients from bayer-sponsored trials to continue regorafenib treatment after their respective study has been completed, and b) to further assess the safety of regorafenib. secondary objective is the documentation of drug tolerability.

Eligibility criteria:
inclusion criteria: * participant must be age-eligible in the feeder study at the time of signing the informed consent. * participant is currently participating in any bayer-sponsored regorafenib study and is receiving study treatment. * participant is currently benefiting from treatment with regorafenib monotherapy and meets criteria to initiate a subsequent cycle of therapy, as determined by the guidelines of the feeder protocol. * any ongoing adverse events that require temporary treatment interruption must be resolved to baseline grade or assessed as stable and not requiring further treatment interruption by the investigator. exclusion criteria: * medical reasons not to start the next treatment cycle in the respective feeder * pregnancy

Keywords: metastatic colorectal cancer (mcrc) renal cell cancer gastro-intestinal stromal tumor hepatocellular carcinoma