Kornimate/medical-research-clean huggingface dataset:
single center, open label, study of preparation h on erythema in relapsing ms patients treated with plegridy

Conditions: Multiple Sclerosis

Summary: the primary purpose of this single center, randomized, open label study in relapsing multiple sclerosis (ms) patients on plegridy (peginterferon beta-1a) is to assess the effect of preparation h (phenylephrine) maximum strength cream compared to no topical treatment of injection site erythema after plegridy injection.


Eligibility criteria:
inclusion criteria: * a confirmed diagnosis of relapsing multiple sclerosis, as defined by mcdonald criteria. * age 18 to 70 years old, inclusive, at the time of informed consent. * naïve to plegridy or less than or equal to 12 months on plegridy therapy. exclusion criteria: * primary progressive, secondary progressive or progressive relapsing ms. * concurrent enrollment in any clinical trial of an investigational product. * known allergy to any interferon or any component of plegridy (peginterferon beta-1a). * known allergy to phenylephrine, pramoxane or any component of preparation h. * history of hypersensitivity or intolerance to naproxen or acetaminophen (tylenol) that would preclude the use of at least 1 of these during the study. * history of inadequate response to subcutaneous interferon beta therapy. * history of human immunodeficiency virus, hepatitis c virus antibody or current hepatitis b infection. * history of premalignant and malignant disease including solid tumors and hematologic malignancies (except basal cell and squamous cell carcinomas of the skin that have been completely excised and are considered cured). * history of any clinically significant cardiac, endocrinologic, hematologic, hepatic, immunologic, metabolic, urologic, pulmonary, neurologic, dermatologic, psychiatric, and renal, or other major disease, as determined by the investigator. * history of seizure disorder or unexplained blackouts. * history of suicidal ideation or an episode of clinically severe depression (as determined by the investigator) within 3 months prior to day 1. * serious local infection (e.g., cellulitis, abscess) or systemic infection (e.g., pneumonia, septicemia), at the discretion of the investigator, within 3 months prior to day 1. * history of drug or alcohol abuse (as defined by the investigator) within 6 months prior to day. * active bacterial or viral infection. * inability to comply with study requirements.

Keywords: multiple sclerosis erythema
tranexamic acid vs fractional co2 laser in post-acne hyperpigmentation

Conditions: Post Inflammatory Hyperpigmentation

Summary: comparing between the effect of intradermal injection of txa and low power low density fractional co2 lasers on post acne hyperpigmentation

randomized controlled split-face study. one side of the face will be assigned to txa intradermal microinjection using kapron 500mg/5ml ampoules (amoun pharmaceutical company), the dose of 1 ml syringe with 100mg/ml. txa will be prepared under sterile conditions. injections will be applied intradermally on hyperpigmented areas at 1cm intervals. the injection will be repeated every two weeks for three months. the other side of the face will be randomly assigned to low power fractional co2 laser with a power of 12 watts, spacing 700 micrometers (low density), and dwell time 300 microsecond every four weeks for three months.

Eligibility criteria:
inclusion criteria: * egyptians of both sexes. * age \> 18. * patients who can avoid sun exposure one week after sessions. * patients who stopped taking systemic isotretinoin for more than six months. exclusion criteria: * pregnancy and lactation. * concomitant use of anticoagulants. * bleeding disorders. * personal or family history of dvt or thromboembolic events. * scarring and keloid tendency. * active skin infection, active hsv. * history of photosensitivity or photosensitizing medication. * occupational sun exposure.
comparison of different mucoactive agents for the care of the intubated patient in a surgical trauma intensive care unit

Conditions: Mucus Obstruction; Intubation

Summary: this study compares n-acetylcysteine (mucomyst) and sodium chloride to determine their efficacy in the prevention of pulmonary mucus obstruction and retention in intubated patients admitted to the surgical trauma intensive care unit (sticu).


Eligibility criteria:
inclusion criteria: * intubated and admitted to the surgical trauma intensive care unit (sticu) * subjects must be eligible to start treatment within 24 hours of their initial intubation exclusion criteria: * patient anticipated to be extubated within 24 hours following sticu admission * hypersensitivity to acetylcysteine. * pregnancy

Keywords: mucus obstruction, ventilator management
flag+ida with g-csf priming for patients younger than 60 years with resistant aml

Conditions: Acute Myeloid Leukemia

Summary: - to determine the feasibility of fludarabine and cytarabine as continuous infusion plus idarubicin with granulocyte-colony stimulating factor priming for patients with resistant acute myeloid leukemia other than acute promyelocytic leukemia

- the feasibility will be evaluated in terms of toxicities, complete remission rate, duration of complete remission, disease-free survival, and overall survival.

Eligibility criteria:
inclusion criteria: * failure to achieve cr after initial induction chemotherapy including standard dose cytarabine. * early relapse, occurring after a first cr lasting less than 12 months. * patients with multiple relapses will be included. * written informed consent must be given. * 15 and 60 years of age. * 2 or less by ecog performance scale. exclusion criteria: * acute promyelocytic leukemia * pregnant or lactating

Keywords: aml
friendship based hiv/sti (sexually transmitted infections) intervention for african american females

Conditions: Sexual Behavior; Sexually Transmitted Diseases; HIV Infections

Summary: the project òré intervention is a half-day community-based hiv/sti intervention program for friendship groups of adolescents that is tailored to african american culture. the four participating community sites will be assigned to either the project òré intervention or a standard health promotion program. sexually experienced african american adolescent females will recruit members of their friendship group for the five-hour program. all participants will complete questionnaires before and immediately following the programs and another one 3 months later. immediately following the program some of the project òré groups will also participate in a focus group to provide feedback about the program.

a group-randomized controlled design to test the efficacy of the project òré intervention, a community-based adolescent social network hiv/sti intervention tailored to african american culture. four community based organization sites (cbos) will be randomly assigned to an experimental or attention control condition. in both conditions, sexually experienced african american adolescent females will recruit members of their friendship group for the five-hour program. in the experimental condition, the intervention group will receive the half-day project òré intervention. the attention control group will receive a standard health promotion control program which has been used previously with similar populations. all participants will complete pre-, post- and 3-month follow-up self-administered questionnaires. in the experimental condition, a subset of groups will participate in a process evaluation focus group immediately following the program.

Eligibility criteria:
inclusion criteria: * female * between the ages of 14-18 * self-identifies as african american * sexually experienced * willing to participate in a single five-hour workshop and a one-hour follow-up session * willing to nominate 2-5 close female friends ages 14-21 to participate in the study with her * lives in the experimental intervention community * ability to obtain permission from parent or legal guardian and assent from minors or consent from those above age of majority exclusion criteria: * individual reports predominantly same gender sexual behavior * recent homelessness * visibly distraught or unstable (i.e. suicidal, manic, exhibiting violent behavior, etc.) * intoxicated or under the influence of psychoactive agents

Keywords: adolescent female community-based social network hiv/sti intervention high hiv-risk african american adolescent females
clinical performance of the hrp2 hs-rdt for malaria diagnosis in pregnant women

Conditions: Plasmodium Falciparum; Pregnancy Malaria; Diagnoses Disease

Summary: this is a cross-sectional and multicentre clinical trial to study the performance of the histidine rich protein 2 (hrp2) highly sensitive rapid diagnostic test (hs-rdt) for the detection of malaria during pregnancy in low transmission settings from colombia and indonesia. the new hs-rdt will be compared with conventional good quality rdts, microscopy, and naats \[loop-mediated isothermal amplification (lamp), nested pcr (npcr)\], in peripheral blood samples with quantitative reverse transcription pcr (qrt-pcr) as reference standard.

the activities proposed will be performed in the context of health centres receiving pregnant women for antenatal care visit. finger-prick blood (300 µl) will be collected and used to test for malaria with the hs-rdt, as well as with conventional good quality rdts, microscopy and local naats (lamp and npcr). dried blood spots will also be collected for qrt-pcr testing. patient information (demographics, obstetric history, malaria prevention measures, etc.) as well as laboratory results will be recorded and entered into a dedicated database.

Eligibility criteria:
inclusion criteria: * women with confirmed pregnancy and registered to the antenatal care programme in the local health centre * resident for at least 1 year in the study site * age ≥ 15 * accepting to participate with willingness to give informed consent (pregnant adolescents younger than 18 y/o (age \< 18) will be considered only if they are accompanied by parent or carer if it is requested by local institutional review boards) * willingness to provide finger-prick blood sample at enrolment exclusion criteria: * past history of malaria and/or antimalarial drugs in the last three months * positive for malaria by microscopy and conventional rdt testing in any previous study screening visit * presence of severe malaria as defined by who guidelines at the moment of recruitment * presence of symptoms and signs of other severe disease and central nervous system infections, as defined by who guidelines.

Keywords: malaria pregnancy diagnosis low-transmission plasmodium falciparum rapid diagnostic test
reading center - occurence of diabetic macular edema in patients with diabetes mellitus in slovak republic

Conditions: Diabetic Macular Edema; Diabetic Retinopathy

Summary: the aim of the study is to find out prevalence of diabetic macular edema (dme) in patients with diabetes mellitus in slovak republic.the outcome of the project will be epidemiology survey, prevalence of wet form of diabetic macular edema in relation to duration of diabetes, type of diabetes, treatment (insulin vs. oad or combination) etc. and identification of prognostic factors leading to development of dme.

epidemiological study, prospective, non-interventional 1. patient with history of diabetes ≥ 10 years or with suspected visual impairment will be enrolled and screened in nied during hospitalization 2. anamnesis and history of diabetes, other co-morbidities, treatment will be recorded 3. patient undergo in nied detailed diabetology examination and basic ophthalmology examination (best non-corrected visual acuity in etdrs score and amsler grid test) 4. patient undergo in nied examination of the back of the eye using fundus camera to take images of retina to assess long-term changes of macula, optic disc, retina vessels and surrounding tissues 5. the assessment of the ophthalmology examination will be carried out in one of two specialized reading centers - ii. eye clinic szu fnsp f.d.r., banská bystrica or oftal specialized hospital for ophthalmology, zvolen by retina specialist the process of screening will be continuous, whilst each patient will sign an informed consent. patients records will be stored electronically and data transmission between nied and reading center will be protected using validated and secured software.

Eligibility criteria:
inclusion criteria: * adults ≥18 years treated in national institute of endocrinology and diabetology * patients diagnosed with diabetes mellitus type i and type 2 respectively * presence of diabetes ≥10 years or patients with suspected visual impairment (duration of diabetes \<10 years) * signed patient´s information and informed content exclusion criteria: * non-compliant patients

Keywords: dme, diabetic retinopathy, diabetes mellitus, epidemiology
pain neuroscience education in chronic musculoskeletal pain

Conditions: Chronic Musculoskeletal Pain

Summary: chronic musculoskeletal pain (cmp) is highly prevalent, disabling and with high socio-economic costs, with many negative effects on quality of life. cmp affects the ability to perform work, social, recreational and domestic tasks by changing the mood and concentration of this population that suffers. in a study carried out in 2010, 17% of the spanish population had experienced pain in the last month and according to the severity of symptoms 12% felt severe , 64% moderate and 24% mild pain. in this same study it is specified that 61% was due to back pain, 29% due to neck pain and 23% due to shoulder pain. pain neuroscience education (pne) has been shown as an effective treatment strategy in increasing knowledge and understanding of neurobiology, neurophysiology and pain processing, modifying beliefs about it, improving patient skills and encouraging to the accomplishment of physical and social activities in different chronic pathologies.

study design and setting: the design of the present study will be a quasi-experimental study with 2 follow-ups (one month and four months after intervention) that will be performed between apr 2018 and apr 2020 in public health system in malaga, spain. the outcomes will be assessed at baseline (t0), one month (t1) and four months after the physiotherapy treatment begins (t2). written informed consent will be acquired for all participants prior to their participation.

Eligibility criteria:
inclusion criteria: * age between 18-65 years * chronic musculoskeletal pain according to the acction-aps pain taxonomy (aapt), included chronic axial musculoskeletal low back pain exclusion criteria: * chronic postoperative musculoskeletal pain and chronic musculoskeletal pain related to a traumatic injury six months before the beginning of the trial * inability to provide written informed consent and/or complete questionnaires in spanish.

Keywords: education chronic pain musculoskeletal pain self-efficacy
safety and efficacy of two oral tinidazole regimens for refractory trichomonas vaginitis

Conditions: Trichomonas Vaginitis

Summary: we compare two oral tinidazole regimens for refractory trichomonas vaginitis.

refractory trichomonas vaginitis has become a clinical problem, which has a direct impact on the health and life of patients. refractory trichomonas vaginitis is mainly caused by drug resistance of trichomonas. drug resistant trichomonas has appeared china. increasing the dosage of anti trichomonal drugs is the main treatment method at present. the aim of this study was to evaluate the efficacy and safety of two oral tinidazole regimens for refractory trichomonas vaginitis.

Eligibility criteria:
inclusion criteria: * women be at least 18 years of age * failure of conventional treatment (recommended by guidelines including tinidazole, 2g once daily for 5-7 days) exclusion criteria: * allergy to metronidazole or tinidazol * pregnant or nursing * hiv or other chronic disease

Keywords: refractory trichomonas vaginitis tinidazole
prevention of persistent opioid use in mothers

Conditions: Opioid Use; Postpartum Disorder; Chronic Pain Syndrome

Summary: our previous work has identified the group of women at risk for prolonged pain, opioid use and poor functional recovery after childbirth. the optimal intervention to mitigate this risk is unknown. we propose to test an analgesic adjutant that is commonly used for post-operative pain compared to placebo to improve post-partum recovery.

a small percent of the large population of women who give birth have difficulty with prolonged pain, opioid use and poor functional recovery. this may be the first opiate exposure and significant health challenge in a young woman's life. in our previous work, we have identified 20% who are at highest risk for prolonged pain and delayed opioid cessation and functional recovery with usual care. moderate to severe pain on postpartum day 1 is a significant predictor of being in the risk group. the optimal intervention to mitigate this risk is unknown. we plan to test an intervention of low dose gabapentin or placebo to be escalated by a pain medicine doctor as needed. we hypothesize that additional care of women predicted to be higher need by virtue of their postoperative day one pain score (\> 6 x2) despite usual multimodal analgesic care will lead to reduced need for opioid, less pain and more rapid functional recovery.

Eligibility criteria:
inclusion criteria: * delivery within 5 days, able to provide informed consent, english speaker exclusion criteria: * opiate use disorder
implementation of precision medicine in high-risk prostate cancer

Conditions: Prostate Cancer

Summary: this project's objective is to initiate a prospective non-interventional clinical study to perform full molecular characterization and subtyping of the primary tumor prostate cancer patients. it will identify, compare, and select biomarkers for treatment response in high-risk/metastatic prostate cancer.

this prospective study includes molecular characterization of the primary tumor, biobanking of urine and blood, questionnaires, collection of health economic parameters, cross-checking of registries to link both other diagnoses and drug use to the different biomarkers and socio-economic parameters. clinical variables including imaging and routine pathology and the outcome of the molecular diagnostic analysis should, in addition to the basic scientific purpose, also be able to identify men who may be eligible for other studies, both pharmaceutical company-funded and investigator-initiated studies. one aim is also to develop the national medical information system already in place for prostate cancer (individual patient record) with molecular profiling and other variables for health estimation, health economics and also enable retrieval from more registries. this study will form the basis for the start of a nationwide study with the aim to prioritize biomarkers for the development of treatment predictive algorithms

Eligibility criteria:
inclusion criteria: * men investigated for suspected prostate cancer * signed consent form exclusion criteria: * difficulties understanding information about the study due to linguistic, cognitive or other reason
by developing a radiomics model to predict the prognosis of patients with hepatocellular carcinoma after microwave ablation

Conditions: Hepatocellular Carcinoma

Summary: developing a radiomics model to predict the prognosis of patients with hepatocellular carcinoma after microwave ablation to provide advice for their treatment.


Eligibility criteria:
inclusion criteria: * patients with primary hepatocellular carcinoma in the department of interventional ultrasound, pla general hospital, who accept mwa therapy for hcc inclusion criteria: 1. primary hepatocellular 2. no other treatments ware performed before microwave ablation 3. patient has been clinically diagnosed with hcc definitely, and have a definite operational indication 4. no extrahepatic manifestations and no evidence of vessel invasion and bile duct thrombi exclusion criteria: * exclusion criteria: 1. non-primary hepatocellular carcinoma or hepatic metastases 2. accept other treatment before microwave ablation 3. extrahepatic metastasis, vessel invasion or bile duct thrombi

Keywords: radiomics prognosis
physical therapy after anti-spastic treatment in children with cerebral palsy

Conditions: Cerebral Palsy

Summary: it is the primary purpose of this pilot study to investigate if physical therapy with strength training is better at improving muscle and gait function after anti-spastic treatment with botulinum toxin compared to physical therapy without strength training in children with cerebral palsy. the investigators hypothesize that it is.


Eligibility criteria:
inclusion criteria: * cerebral palsy (diplegia and hemiplegia) * indication for anti-spastic treatment with botulinum toxin exclusion criteria: * fixed contractures

Keywords: motor control spasticity
srae with embospheres for hemorrhoids.

Conditions: Embolization; Hemorrhoids

Summary: in this study , safety and efficacy of superior rectal artery embolization with embospheres will be researched prospectively.

symptomatic hemorrhoidal disease is a still important public health problem although there are many surgical and nonsurgical minimal invasive treatment methods. treatment methods are not satisfactory or invasive in some percent of the patients. superior rectal artery embolization(srae) for hemorrhoids is an adapted technique derived from doppler-guided hemorrhoidal artery ligation (dghal). in this technique, the distal branches of the superior rectal artery arising from the inferior mesenteric artery is occluded endovascularly with coils. its feasibility and safety were supported by articles. collateralization and recurrence was seen following coil embolization. to prevent this , tri-acryl gelatin microspheres in 500-700 and 700-900 micrometers in size will be used. safety and efficacy of embolization and using different sized particles will be evaluated.

Eligibility criteria:
inclusion criteria: * patients with symptoms of hemorrhoidal disease * patients with written informed consent * patients refusing surgery or other interventional methods * patients with high risk for surgery * patients accepting follow ups exclusion criteria: * previous intervention * colorectal diseases other than hemorrhoids * patients with anal stenosis * patients with rectal prolapsus * pregnant patients * patients with contraindications for technical steps or contrast usage. * patients do nor or could not give written informed consent

Keywords: hemorrhoids superior rectal artery embolization microspheric particles
study of metformin pharmacogenetics in twins

Conditions: Type 2 Diabetes

Summary: the trough concentration of metformin will be examined in monozygotic and dizygotic twins. current twin study will determine the total weight of genetics on the trough concentration of metformin.


Eligibility criteria:
inclusion criteria: * age 18-40 years * both twins has to be included * dizygotic twin pairs has to be same sex * informed consent given * healthy condition exclusion criteria: * chronical/daily alcohol abuse * hypersensitivity to metformin * ingestion of drugs containing topiramate or x-ray contrast fluids * for women: positive pregnancy test/breastfeeding at the beginning of the trial. no use of safe anticonceptives
neuromuscular block in laryngeal mask airway(lma) insertion

Conditions: General Anesthesia; Breast Disease

Summary: the aim of this study is to evaluate the success rate, insertion time and complication depending on the use of neuromuscular blocking agent when inserting the laryngeal mask airway (lma).


Eligibility criteria:
inclusion criteria: * 18-70 year * american society of anesthesiologist status 1-2 * elective general anesthesia exclusion criteria: * known or predicted difficult airway * recent sore throat * mouth opening less than 2.5 cm * at risk of aspiration