Kornimate/medical-research-clean huggingface dataset:
health economics evaluation of catheter ablation versus drug therapy in atrial fibrillation (af) in china

Conditions: Atrial Fibrillation

Summary: to generate real world evidence to compare clinical outcomes and patient health-related quality of life, resulting from catheter ablation therapy with clinical outcome and patient health-related quality of life resulting from drug therapy in china. an economic model will be constructed, and using the clinical events evidence collected in this study, and china long-term disease progression and local disease cost data to perform a cost-effectiveness evaluation of catheter ablation versus drug therapy in af (paroxysmal plus persistent af) patients.

the evidence generated by this study is expected to help inform medical decision makers with the clinical and economic data of therapy for af patients, and also provide policy decision makers with information that can be considered /used to allocate funds for af ablation and permit patients to have access to appropriate treatment options for af management.

Eligibility criteria:
inclusion criteria: * patients with paroxysmal or persistent af eligible for catheter ablation * age 18 to 80 years * able and willing to comply with all pre,post and follow-up testing and requirements. * be able to sign irb/ec approved informed consent form. exclusion criteria: * terminal illness with a life expectancy less than 1 year. * new york heart association (nyha) class iii or iv * previous recipient of catheter ablation therapy for af * bradycardia and previous recipient of pacemaker therapy * previous recipient rfca or icd therapy * uncontrolled hypertension * recent cardiac events including mi, pci, or valve or bypass surgery in the preceding 3 months * patients with serious hepatic and renal diseases * pregnant or prepare to be pregnant in one year * for drug therapy arm, if the subject cannot be contacted via phone or the subject shows his/her disagreement to this study at 30 day window, the subject will be withdrawn from this study.

Keywords: catheter ablation versus drug therapy in af in china
correlation between preoperative images of ppgl and intraoperative hemodynamics

Conditions: Pheochromocytoma; Paraganglioma

Summary: this is a retrospective observational cohort study involving patients with suspected ppgls who underwent 131i-mibg scanning and surgical treatment between january 2020 and april 2023. the objective is to evaluate the correlation between mibg imaging score and intraoperative hemodynamic fluctuations.

this is a retrospective observational cohort study involving patients with suspected ppgls who underwent 131i-mibg scanning and surgical treatment between january 2020 and april 2023. the objective is to evaluate the correlation between mibg imaging score and intraoperative hemodynamic fluctuations.

Eligibility criteria:
inclusion criteria: * patients with suspected ppgls who received 131i-mibg scintigraphy and were treated by surgery exclusion criteria: * 1) surgery was performed more than 6 months after 131i-mibg scintigraphy; 2) tumor located in bladder where radioactive urine would influence assessment of tumor; 3) tumor was not resected as a whole; 4) resected tumor was not ppgls confirmed by pathology; 5) 131i-mibg scintigraphy images or intraoperative bp was not available for assessment.
the safety, feasibility and oncological outcomes of laparoscopic completion total gastrectomy for remnant gastric cancer

Conditions: Remnant Gastric Cancer

Summary: this study aims to investigate the safety, feasibility, and long-term oncological outcomes of laparoscopic completion total gastrectomy for remnant gastric cancer.

in 2005, since yamada reported the first case of laparoscopic completion total gastrectomy (lctg) for rgc, laparoscopic technology was widely used in the treatment of rgc. however, due to the low incidence and rapid aggravation of rgc, adhesion, anatomic changes, and more complex lymphatic pathways caused by the previous operation, the popularity of lctg is limited. therefore, higher level evidence is warranted to further confirm the safety, feasibility, and oncological outcomes of lctg in patients with rgc. this prospective single-arm study is designed to evaluate the safety, feasibility, and long-term oncological outcomes of laparoscopic completion total gastrectomy for remnant gastric cancer.

Eligibility criteria:
inclusion criteria: age between 18 and 75 years; carcinomas arise in the remnant stomach following gastrectomy, irrespective of the histology of the primary lesion (benign or malignant) or its risk of recurrence, the extent of resection, or the method of reconstruction; ct1-4a, n-/+, m0 at preoperative evaluation according to the ajcc cancer staging manual, 7th edition; performance status of 0 or 1 on ecog scale; asa class i, ii, or iii; written informed consent. exclusion criteria: distant metastasis in the preoperative examinations; previous upper abdominal surgery (except laparoscopic cholecystectomy, previous gastrectomy, endoscopic mucosal resection or endoscopic submucosal dissection); other malignant diseases (except gastric cancer) within the past 5 years; enlarged or bulky regional lymph node (diameter over 3cm) supported by preoperative imaging including enlarged or bulky no.10 lymph nodes; women during breast-feeding or pregnancy; severe mental disorder; unstable myocardial infarction, angina, or cerebrovascular accident within the past 6 months; history of continuous systematic administration of corticosteroids within one month; fev1\<50% of predicted values; requirement of simultaneous surgery for other disease; emergency surgery due to complications (bleeding, obstruction, or perforation) caused by gastric cancer.

Keywords: laparoscopic completion total gastrectomy remnant gastric cancer feasibility prognosis
optimizing chronic pain treatment with enhanced neuroplastic responsiveness

Conditions: Pain; Osteoarthritis

Summary: the purpose of the study is to identify non-invasive strategies that will optimize the neurobiological environment and improve learning and memory in the treatment of chronic pain. the overall aims of the current proposal are to determine if food restriction and/or glucose administration in conjunction with a relaxation/guided imagery exercise will result in neurophysiological changes and functional improvements compared to the relaxation/guided imagery exercise alone.

up to sixty adults with chronic knee pain with or/at risk of knee osteoarthritis will be randomized to one of three groups: food restriction (20 participants), glucose administration (20 participants), or control (20 participants). participants will attend four sessions over a two to three week period.

Eligibility criteria:
inclusion criteria: * adults with chronic knee pain with or/at risk of knee osteoarthritis exclusion criteria: * concurrent medical condition that could confound outcome measures or limit the ability to participate completely in the protocol including: neurological conditions (parkinson's disease, multiple sclerosis, and/or seizures) * history of a head injury or stroke * diabetes or taking medications to control blood sugar * mental health issues resulting in hospitalization or outpatient treatment in the past year, and/or psychotropic medication use * current issue or history of treatment for alcohol or other substance abuse * cognitive function \< or = 22 on the mini-mental status exam * pregnancy * a baseline fasting blood sugar (plasma glucose \> 7mmol/l) or persisting blood pressure \>150/95. * heart condition such as a prior heart attack, heart surgery (including a stent), frequent chest pain or heart failure * inability to complete the eeg portion of the study

Keywords: neuroplasticity
the effect of hysterotomy technique on the rate of large defects in the hysterotomy scar

Conditions: Scars

Summary: the effect of cesarean operative technique on the occurrence of large hysterotomy scar defects.

having a caesarean leads to a scar in the uterus, which does not always heal properly. defective healing can lead to serious complications in the next pregnancy and delivery. different surgical techniques can be used for a caesarean section. the aim is to compare two surgical techniques (different ways of opening the uterus), to investigate whether one or the other technique leads to fewer defective scars in the uterus. both these techniques are in use at the clinic. after the operation, patients are cared for in the normal way. six months after the caesarean, patients are examined using vaginal ultrasound. vaginal ultrasound allows to see if the scar after the caesarean has healed well, or if there are defects in it.

Eligibility criteria:
inclusion criteria: * ≥ 18 years old * gestational age ≥ 37 gestational weeks * cervical dilatation ≥5 cm, * no previous uterine surgery other than cone biopsy, loop electrosurgical excision procedure, dilatation and curettage, or dilatation and evacuation, undergoing emergency caesarean section. exclusion criteria: • need of immediate caesarean section, defined as delivery of the baby within 20 minutes.

Keywords: caesarean
effects of dietary fibre on glucose metabolism and satiety

Conditions: Obesity; Metabolic Syndrome

Summary: the experimental model is a semi-acute study where the purpose of the study is to evaluate food factors related to colonially derived regulation of glucose metabolism (and related parameters) and satiety in healthy subjects.


Eligibility criteria:
inclusion criteria: * normal fasting blood glucose, bmi 19-25 kg/m2 exclusion criteria: * gastrointestinal diseases or food allergies e.g. lactose-, gluten intolerance, metabolic disorders e.g. diabetes, tobacco/snuff users. antibiotic or probiotic usage within two weeks, and during study. vegetarians.
evaluation of the tolerability and efficacy of cwt-f-002 lubricant eye drops

Conditions: Dry Eye Disease

Summary: the primary objective is to evaluate the tolerability and efficacy of cwt-f-002 lubricant eye drops in the treatment of the signs and symptoms of dry eye disease.

in this study cwt-f-002 lubricant eye drop is being evaluated in subjects with dry eye. this otc eye drop has previously shown promising results in multiple preclinical and clinical settings. the active comparator for this study is systane (r). ingredient lists as follows. cwt-f-002: active ingredients are glycerin 0.7% and polyethylene glycol 400 0.4%. inactive ingredients are mannitol, polylysine-graft-polyethylene glycol, sterile water for injection, and sodium phosphate buffer. systane: active ingredients are polyethylene glycol 400 0.4% and propylene glycol 0.3%. inactive ingredients are boric acid, calcium chloride, hydroxypropyl guar, magnesium chloride, potassium chloride, purified water, sodium chloride, zinc chloride. systane (r) may contain hydrochloric acid and/or sodium hydroxide to adjust ph. both products are preservative free and supplied in unit dosers.

Eligibility criteria:
inclusion criteria: * be at least 18 years of age * have a reported history of dry eye for at least 6 months * have a tear film breakup time (tfbut) measurement of \>1 and \<7 seconds at visit 1 exclusion criteria: * known contraindications or sensitivities to the use of the study treatment or any of its components * have a clinically significant slit lamp finding at visit 1 that may include active blepharitis, meibomian gland dysfunction (mgd), lid margin inflammation, or active ocular allergies that require therapeutic treatment, and/or in the opinion of the investigator may interfere with study parameters * have a condition (ocular or systemic) that the investigator feels may put the subject at significant risk, may confound the study results, or may interfere significantly with the subject's participation in the trial

Keywords: corneal epitheliopathy tear film stability
etodolac-lidocaine patch in subjects experiencing acute delayed onset muscle soreness

Conditions: Acute Delayed Onset Muscle Soreness (DOMS)

Summary: this study evaluate the efficacy and safety of etodolac-lidocaine topical patch applied one time daily when compared with placebo in the treatment of acute delayed onset muscle soreness (doms) of the upper limbs.


Eligibility criteria:
inclusion criteria: * have not engaged in significant upper extremity fitness activities for more than two times per week for ≥ 2 consecutive weeks in the past 6 months prior to screening. * subject has a body mass index of between 18 and 30 kg/m2, inclusive. * subjects who report a pain with movement score in both arms of at least 5 (based on a 0-10 nrs) secondary to doms approximately 24 to 30 hours after each arm was exercised. exclusion criteria: * presence of another painful physical condition that, in the opinion of the investigator, may confound study assessments. * use of pain medication (including anti-inflammatory drugs) prior to the exercise visit until 72 hours after randomization. * use of any corticosteroids (oral, injectable, topical, inhaled) from before the exercise visit until randomization. corticosteroids must be washed out by at least 3 days before the exercise visit. * chronic or acute renal or hepatic disorder, inflammatory bowel disease (e.g., crohn's disease or ulcerative colitis) or a significant coagulation defect. * history of allergy (cutaneous or systemic), asthma, hypersensitivity to any of the following: etodolac, lidocaine, paracetamol (acetaminophen), acetylsalicylic acid, salicylic acid, other nsaid, other local anesthetic, known intolerance (cutaneous or systemic) to any of the ingredients in the patch.
cystea-bone clinical study

Conditions: Nephropathic Cystinosis

Summary: nephropathic cystinosis (nc) is an orphan inherited autosomal recessive disease characterised as a generalized lysosomal storage disease due to a deficiency of the cystine lysosomal transport protein, cystinosin. patients with nc usually receive cysteamine. bone impairment was recently recognized as a late complication of nc, occurring at adolescence or early adulthood. even though the exact underlying pathophysiology is unclear, at least six hypotheses are discussed, and mainly cysteamine toxicity and/or direct bone effect of the cystinosin (ctns) mutation. because of the potential dramatic impact on quality of life of this novel complication, research should aim to better understand bone disease in nc. the primary objective of this study is to evaluate the action of cysteamine on osteoclastic differentiation and resorption activity of nc patients, depending on the underlying genotype. the secondary objective is to describe the clinical bone status of nc patients depending on their underlying genotype.


Eligibility criteria:
inclusion criteria: * male and female subjects with confirmed diagnosis of nephropathic cystinosis (defined by clinical signs, white blood cells (wbc) cystine level and/or mutation), currently receiving oral cysteamine. * age \> 2 years. * subjects and/or their parents/ legal guardian must provide non opposition prior to participation in the study. exclusion criteria: * subjects who, in the opinion of the investigator, are not able or willing to comply with the protocol.
the effects of internet-based and supervised exercise programs in people with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the main aim of this study is resarch and compare the effects of supervised exercise programs and internet-based exercise programs, which have started to benefit from their effects in recent years, known for not requiring conditions such as transportation distance, cost and time, on motor disorders and quality of life in people with multiple sclerosis (ms). this study conducting for develop a new perspective on conventional physiotherapy and rehabilitation practices. our study will be performed in people with ms with a high edss score, is seen as an important contribution for the literature.

the groups were included in exercise programs of 16 sessions in total, twice a week for 8 weeks. exercise programs will consist of warm-up, aerobic exercises, strengthening exercises, balance exercises, breathing exercises, cooling and relaxation exercises. exercise programs will be created by the physiotherapist and arranged every 2 weeks according to the patients' conditions. patients who do not participate in the program 2 times in a row will be excluded from the study.

Eligibility criteria:
inclusion criteria: * diagnosed with ms by a neurologist * being between ages of 18-65 * not having had an attack in the last 3 months * the score of expanded disability status scale (edss) is 5.5- 7.5 * not participating in a another physiotherapy and rehabilitation program * having internet access exclusion criteria: * pregnancy * severe cognitive impairment that effects participating to rehabilitation * the cardiopulmonary disease that will prevent aerobic exercise * having a major hearing and/or vision problem * having a major speech disorder

Keywords: balance multiple sclerosis exercise
development of a novel method to measure insulin sensitivity in humans: a pilot study

Conditions: Insulin Sensitivity

Summary: this study will determine whether the ratio between 24h c-peptide urinary excretion rate and average 24h circulating glucose represent a good correlate of what is measured by the gold standard, i.e. m (glucose disposal rate) from a euglycemic-hyperinsulinemic clamp


Eligibility criteria:
inclusion criteria: * healthy male or female * age 18-65 y * bmi between 20 kg/m2 and 35 kg/m2 (inclusive) * are willing to consume pre-prepared meals * have completed a high-dose (≥80 miu/m2/min) euglycemic-hyperinsulinemic clamp during the last five years at pennington biomedical. the data from the previous pbrc clamp will be pulled and used in conjunction with data from this study. * willing to have blood and urine stored for future use exclusion criteria: * major lifestyle changes since the euglycemic-hyperinsulinemic clamp was performed (i.e. gain/lost weight, stopped smoking, began/stop exercise). * unstable weight in the last 3 months \[gain or loss \>10 lb (or 4.5 kg)\] * diagnosed with diabetes * untreated hypertension and average screening blood pressure \>140/90 mmhg * previous bariatric surgery (or other surgeries) for obesity or weight loss * chronic use of medications affecting metabolism or sleep\* * history of neurological disease * history of cardiovascular disease, or other chronic diseases, that might affect pancreatic or glucose metabolism. * pregnant, planning to become pregnant, or breastfeeding * adherence to special restrained diets (e.g., low-cho, low-fat, or vegetarian/vegan diets) over the last 3 months. \*sporadic use of these medications is fine (however, enrollment will depend on a case-by-case basis). if taking sporadically, participants should not be taking the medication for 1-month prior to the first visit.
choledochotomy techniques during lcbde

Conditions: Choledocholithiasis

Summary: complications after laparoscopic common bile duct exploration (lcbde) regarding the choledochotomy technique have not been adequately studied in the literature. therefore, this study aimed to retrospectively analyze and compare the impact of choledochotomy techniques during lcbde among patients with choledocholithiasis during the early and late postoperative periods.

background: complications after laparoscopic common bile duct exploration (lcbde) regarding the choledochotomy technique have not been adequately studied in the literature. therefore, this study aimed to retrospectively analyze and compare the impact of choledochotomy techniques during lcbde among patients with choledocholithiasis during the early and late postoperative periods. methods: from march 2014 to february 2018, 85 patients with choledocholithiasis (52 females and 33 males) were enrolled in this study. these patients were treated by lcbde using various choledochotomy techniques, including scalpel or scissor (28 patients, 33%) in group i, using diathermy hook (35 patients, 41%) in group ii, or using an ultrasonic device (22 patients, 26 %) in group iii. postoperative follow-up was done for assessment of all possible complications either early (within 3-6 months postoperatively), or late (2-6 years postoperatively) with meticulous observation and study of any relevant postoperative event.

Eligibility criteria:
inclusion criteria: * all adult patients with choledocholithiasis who underwent lcbde combined with lc were enrolled in this study. no limitations as regards the stone sizes or numbers were considered. the cbd diameter should be at least ± 1 cm. exclusion criteria: * exclusion criteria were normal caliber or stenosed cbd, or the presence of overt cholangitis. additionally, treated patients with the trans-cystic approach for stone extraction were excluded from this study.

Keywords: choledochotomy technique cbd stones choledocholithiasis
retrospective evaluation of crofab - efficacy in severe envenomation

Conditions: Snake Envenomation

Summary: retrospective observational review of severe envenomation treatment with crofab

the objective of this study is to use previously collected retrospective observational data to compare treatment and outcome in patients treated with crofab who have a severe envenomation to those with a mild/moderate envenomation.

Eligibility criteria:
inclusion criteria: * must involve treatment of a human patient with crofab between january 1, 2002 and december 31, 2004 * the record must contain all of the following: 1. clinical signs/symptoms prior to the first dose of antivenom, 2. documentation of all doses of antivenom used to treat the patient, 3. indication of whether or not initial control was achieved with antivenom. to be included in the efficacy evaluable population (eep) in the current analysis, each record must meet the following criteria: * must contain enough information to calculate a severity score based on the 7-point severity scale. * all records were included in the safety population in the current analysis. exclusion criteria: * any cases identified that do not meet the inclusion criteria were excluded, including cases not treated with crofab.