Kornimate/medical-research-clean huggingface dataset:
thrombectomy revascularization of large vessel occlusions in acute ischemic stroke (trevo)

Conditions: Ischemic Stroke

Summary: to determine the revascularization rate of the ce-marked trevo device in large vessel occlusions in ischemic stroke patients. * revascularization, defined as at least tici 2a in the vascular territory treated at end of the neuro interventional procedure.

* clinical outcomes at 90 days * mortality at 90 days * device-related serious adverse events (drsaes) * symptomatic ich rate within 24 (-6/+12) hours post-procedure

Eligibility criteria:
inclusion criteria: * age 18-79 (has had 18th birthday, but not yet had 80th birthday) * nihss 8 - 30 * anticipated life expectancy of at least 6 months * no significant pre-stroke disability (mrs less than or equal to 1) * written informed consent to participate given by patient or legal representative * angiographic confirmation of a persistent large vessel occlusion, in the internal carotid, middle cerebral m1 and/or m2 segments, basilar or vertebral arteries * treatable within 8 hours of symptom onset, defined as the first pass being made with the trevo device. exclusion criteria: * baseline glucose of \ 400 mg / dl (22.20 mmol) * known hemorrhagic diathesis, coagulation factor deficiency, or oral anticoagulant therapy with inr \> 3.0 * treated with heparin within 48 hours with a ptt greater than 2 times the lab normal * baseline platelet count \< 30,000 * history of severe allergy (more than rash) to contrast medium * severe, sustained hypertension (sbp \> 185 mm hg or dbp \> 110 mm hg) note: if the blood pressure can be successfully reduced and maintained at the acceptable level using medication (i.e. nipride), the patient can be enrolled * woman of child bearing potential who is known to be pregnant * patient participating in another clinical study or protocol * for anterior circulation strokes: strokes involving greater than 1/3 of the mca territory, as determined by hypodensity on the baseline non- contrast ct, or low cbv on ct perfusion imaging, or restricted diffusion on dwi images * for posterior circulation strokes within the midbrain and/or pons, extensive hypodensity on the baseline ct, or low cbv on ct perfusion imaging, or extensive restricted diffusion on dwi images * baseline ct/mr evidence of significant mass effect with midline shift * baseline ct/mr evidence of hemorrhage * baseline ct/mr evidence of intracranial tumor (except small meningioma) * angiographic evidence of vasculitis or arterial dissection * high grade stenosis that cannot be treated safely or which prevents access to the thrombus with the trevo device * angiographic evidence of excessive arterial tortuosity that precludes the trevo device from reaching the thrombus

Keywords: stroke ischemic thrombus embolectomy thrombectomy concentric embolus mechanical trevo
perception of appearance and social acceptance between cleft and non-cleft children in early adolescence

Conditions: Cleft Lip and Palate; Social Isolation

Summary: background: using three-dimensional (3d) surface imaging, this study aims to understand the differences in perception between schoolchildren with and without cleft lip and palate (clp), as well as to explore peer awareness and acceptance of children with craniofacial abnormalities post-surgery. methods: this cross-sectional study utilized three-dimensional surface images of early adolescent patients with clp post-repair and without clp for examination by schoolchildren (with clp and without). both groups assessed the images and responded to a questionnaire eliciting perceptions of facial appearance and social acceptance of children with craniofacial abnormalities, rating each question on a likert scale of one to five. the results were presented using bar graphs, and the item response theory-graded response model was employed to estimate the latent ability (θ) of each participant. the reliability of the questionnaire was assessed with cronbach's alpha test.


Eligibility criteria:
inclusion criteria: * cleft patient received cleft surgical treatment including lip repair, palatoplasty, and alveolar bone grafting in our craniofacial center, based on our cleft surgical protocol exclusion criteria: * unable to complete the questionnaire on their own for any reason were excluded to avoid bias in responses caused by the presence of a secondary observer

Keywords: cleft lip and palate three-dimensional image technique adolescent peers aesthetic evaluation psychosocial impact
evaluation of staple watson wrist arthrodesis

Conditions: Osteoarthritis Wrist

Summary: when the wrist is damaged, for traumatic or degenerative reasons, the cartilage is worn out and the bones rub together: this is osteoarthritis. in order to stop this pain, it may be necessary to block these bones from each other, sacrificing mobility to achieve indolence. multiple techniques are described according to the type of osteoarthritis and for each type of osteoarthritis itself, but the principle remains the same. the methods currently commonly proposed are the staple and the screwed plate. the aim of the study is to evaluate the surgical practice of the orthopaedics and traumatology department of the university hospital of rennes, and its long-term results, as this type of surgery is intended to be definitive.

the surgery performed in the orthopaedics and traumatology department of the university hospital of rennes, has 2 notable points: its technique and its equipment. * the procedure is based on the staples 4fusion1 (stryker/memometal), which is still poorly assessed in the literature. * the surgical procedure has several technical specificities: intra osseous cartilage freshening and preservation of the lunotriquetral ligament if intact.

Eligibility criteria:
inclusion criteria: * adult patients * all patients operated on for a 4-bones arthrodesis performed by stapling at the chu rennes between 1 january 2008 and 31 december 2017 with 4fusion stapling * patients who gave consent after full information exclusion criteria: * refusal to participate after information * protected adults * person deprived of liberty

Keywords: orthopaedic surgery staples
post-operative analgesic selection in patients planned for third molar extraction after undergoing shared decision making using 2- versus 3-option decision-aids

Conditions: Pain Management; Shared Decision Making

Summary: this research protocol is exploring a behavioral intervention: shared decision making with the use of a decision aid to select a post-operative analgesic. specifically, the investigators will examine the impact of shared decision making on analgesic selection for acute pain management when 2 options are presented to the patient as compared to 3 options which includes an opioid prescription for "just-in-case" pain management. the investigators hypothesize that significantly more patients will choice an opioid option when the "just-in-case option is included.

dentists often prescribe opioids to their patients to manage acute post-surgical pain, with hydrocodone/acetaminophen being the most commonly prescribed opioid combination. with an estimated 56 million tablets of hydrocodone prescribed to 3.5 million high school and young adults each year after third molar extractions, it is vitally important to develop the best evidence for acute pain management following dental procedures. dentists are among the leading prescribers of opioid analgesics, writing up to 12% of all opioid prescriptions and 31% of opioid prescriptions for young patients. shared decision making is an integral component of patient-centered clinical care. decision aids have been shown to be effective in improving patient satisfaction, and one study suggests shared decisions have the potential to decrease the number of opioids tablets prescribed. shared decision making studies on analgesics selection for out-patient surgery, however, are limited and no studies have investigated the "just in case" phenomenon which send a message that the opioid options are better than the non-opioid options.

Eligibility criteria:
inclusion criteria: * be able to understand the informed consent. * provide signed and dated informed consent form * be able to understand all directions for data gathering instruments in english * be willing and able to comply with all study procedures * planning to undergo extraction of one or more 3rd molars * be 18 years or older exclusion criteria: while the actual analgesic prescribed to the patient may be different then the analgesic selected by the participant (their actual analgesic is not part of the research protocol) participants who self-report inability to take ibuprofen, acetaminophen or an opioid are not eligible since the decision aid is designed to help a patient select between a combination of ibuprofen/acetaminophen and an opioid containing analgesic. participants would also be excluded due to any additional criteria that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study which includes: * prior participation in this study * inability or refusal to provide informed consent

Keywords: analgesic selection shared decision making decision aid non-opioid analgesic
rib raising for post-operative ileus

Conditions: Intestinal Pseudo-Obstruction; Manipulation, Osteopathic; Postoperative Care; Postoperative Nausea and Vomiting; Postoperative Complications; Osteopathic Medicine

Summary: we are conducting a randomized controlled trial the use of rib raising for post-operative ileus. rib raising is an osteopathic manipulative technique (omt). we will recruit all patients undergoing major abdominal surgery and once they have been enrolled, we will randomize them to receive daily rib raising or a control technique where we place hands on the back but do not apply any pressure. in preliminary studies, rib raising has been shown to reduce post-operative ileus and hospital length of stay by up to 50%.


Eligibility criteria:
inclusion criteria: * major abdominal surgery (laparotomy, laparoscopy excluding simple laparoscopic appendectomy or laparoscopic cholecystectomy) exclusion criteria: * open abdomen for \>72 hours * prior history of major post-operative complications * intolerance to anesthesia * co-morbidities including osteoporosis and osteopenia * spine or rib fractures * pregnancy * prisoners * history of osteopathic manipulation * recruitment delayed beyond 48 hours * surgeon requested exclusion
physical therapy in pregnant women with preeclampsia

Conditions: Preeclampsia

Summary: the aim of this study is to evaluate the influence that has a physical therapy protocol in maternal and fetal hemodynamics in relation to blood pressure, maternal and fetal responses and perinatal outcomes.

the hypertensive disorders in pregnancy affecting 5-8% of pregnant women worldwide, contributing significantly to maternal and fetal complications. various forms of hypertensive disorders occurring during pregnancy, including preeclampsia and chronic hypertension with superimposed preeclampsia. these two disorders present with high blood pressure and proteinuria, and often lead to the hospitalization of pregnant women. the objective is to evaluate the effectiveness of a physical therapy protocol used in pregnant women with preeclampsia on blood pressure, maternal-fetal outcomes and perinatal outcomes. participants in the study pregnant women with preeclampsia and hypertension with superimposed pre-eclampsia, hospitalized, with no significant complications that may impair the normal course of pregnancy. all pregnant women are monitored through laboratory and clinical data and the fetus monitored by tests that assessed their vitality, in addition, pregnant women in the intervention group performed the proposed physiotherapeutic the study protocol.

Eligibility criteria:
inclusion criteria: participed of the study, high-risk pregnant women with gestational age between 24 and 38 weeks, hospitalized with a diagnosis of preeclampsia or chronic hypertension with superimposed preeclampsia, with no other maternal diseases and absence of fetal diseases by diagnostic ultrasound examinations and fetal well. exclusion criteria: * pregnant women who became symptomatic (blurred vision, epigastric pain, headache) secondary to the hypertensive process; * 24-hour proteinuria above 2 g * laboratory abnormalities (thrombocytopenia, alteration of renal function, elevated liver enzymes, elevated bilirubin); * request the patient to leave the project.

Keywords: women with preeclampsia physical therapy maternal-fetal hemodynamics perinatal outcomes
temozolomide versus dacarbazine in stage iv metastatic melanoma (study p03267)

Conditions: Melanoma

Summary: the purpose of this study is to ascertain if the extended schedule of temozolomide, which allows increased doses and potential depletion of the enzyme underlaying resistance, is a more effective treatment of metastatic melanoma than single agent dacarbazine.


Eligibility criteria:
inclusion criteria: * histologically confirmed, stage iv, surgically incurable melanoma * age 18 years or older * world health organization (who) eastern cooperative oncology group (ecog) performance status of 0 or 1 * meets protocol requirements for specified laboratory values * must be able to take oral medication * must be disease free from cancer for period of 5 years (except for surgically cured carcinoma in-situ of the cervix and basal or squamous cell carcinoma of the skin). * women of childbearing potential and men must be practicing a medically approved contraception. * must provide written informed-consent to participate in the study. * must have full recovery from major surgery or adjuvant treatment * no clinically uncontrolled infectious disease including hiv or aids-related illness exclusion criteria: * ocular melanomas * brain metastases * prior cytokine or chemotherapy for stage iv disease * pregnant or nursing women

Keywords: metastatic melanoma
intraoperative case series study: trial rasp position versus sl-plus™ mia ti/ha femoral hip stem position

Conditions: Osteoarthritis

Summary: a prospective, multicenter, observational study using the sl-plus™ mia ti/ha femoral hip stem with the appropriate set of instruments.

the study objective was to evaluate if there was a difference between the femoral position of the last trial rasp and the final implant position of the sl-plus™ mia ti/ha femoral hip stem. the femoral position of rasp or stem was considered as the height of the implant / rasp in cranio-caudal direction.

Eligibility criteria:
inclusion criteria: patient: * requires primary tha with the sl-plus™ mia ti/ha femoral hip stem * is at least 21 years of age at the time of surgery * is skeletally mature in the pi's judgment * has consented to participate in the study by signing the ec approved icf exclusion criteria: patient: * requires the use of a ceramic-on-ceramic bearing * has infections, acute or chronic, local or systemic * has severe muscle, nerve or vascular diseases that endanger the respective limb * has lack of bone substance or defective bone quality that jeopardizes the stable seating of the prosthesis * has any concomitant disease that may jeopardize implant function * has a known allergy to study device or one or more of its components * requires a revision surgery and has extensive bone defects * has diagnosis of an immunosuppressive disorder * is pregnant
efficiency of monitoring and control program of hypertension through pharmacy offices. apof project

Conditions: Hypertension

Summary: background: hypertension in adults is the factor most prevalent cardiovascular risk and motivates further inquiries, generating a very high cost of medical care. objective: to evaluate the monitoring of well-controlled hypertensive patients pharmacy offices. hypothesis: the monitoring of these patients through the office of pharmacy will be as effective in obtaining good control of blood pressure as it is to obtained through health centers. design: multicenter randomized controlled trial along one year of follow up. location: the city of cerdanyola del vallès (barcelona). participants: all patients diagnosed with hypertension and good control criteria in the past year. arms: health centers (control) and pharmacy offices (intervention). outcome variable: blood pressure under good control along the monitoring


Eligibility criteria:
inclusion criteria: * age not less than 18 years * hta controlled over 2 years of evolution * subjects with a history open to participating health centers or stable residence in the geographic area * subjects who agree to participate exclusion criteria: * comorbidity and concomitant (diabetes mellitus, heart failure or renal failure * patients with temporary residence in the geographic area of study * subjects of hypertension controlled by outside professionals to our primary care teams. * subjects with home care or any other cause which does not permit their displacement, transfer to the clinic or pharmacy during the evaluation period. * subjects with severe diseases of poor prognosis, hopefully less than one year of life. * subjects who do not have telephones. * subjects with communication problems (cognitive impairment, sensory, language barrier)

Keywords: blood pressure monitoring, ambulatory arterial pressure hypertension controlled pharmacies
magnethermopro : magnetic resonance thermography of human prostate

Conditions: Prostate Cancer Diagnosis

Summary: the objective of this project is to offer a very innovative solution for measuring temperature variations in mri on the prostate. multiparametric prostate mri can detect target lesions, on which targeted biopsies are then performed. the use of a temperature mapping on the prostate in mri would make it possible to evaluate a focal treatment of the prostate by laser under mri guidance

prostate mri has become the benchmark examination to search for tumor targets, thanks to a multi-parameter protocol, including t2 sequences, diffusions, and t1 with gadolinium injection. a pirads prognostic score is performed on the different sequences and if the lesions are at high risk of malignancy (pirads 4 and 5), a targeted biopsy is performed. minimally invasive ablations called focal treatments are developing more and more: hifu, cryotherapy, laser, etc. ultrasound remains the most widespread examination due to its availability, but with less sensitivity than mri. ablations are performed under ultrasound with fusion of mri images in order to assess the ablation area under mri, the measurement of temperature variations appears necessary to verify the effectiveness of ablation and the lesion volume. temperature maps are feasible in cardiac mri during radiofrequency. the thermal mapping mri sequence is performed in cardiac mri at the ihu in bordeaux.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * patient with indication of injected multi-parameter mri for the diagnosis of prostate cancer. * signed informed consent. * person affiliated or beneficiary of health insurance exclusion criteria: * mri contraindications (pace maker, metallic foreign body, metallic heart valve). * contraindication to gadolinium salt, * patient under legal protection

Keywords: mri prostate thermometry laser ablation
impact of dried moringa oleifera leaves in enhancing hemoglobin status

Conditions: Anemia, Iron Deficiency

Summary: this research project is aimed at combating the nutritional deficiencies (iron deficiency anemia) of reproductive aged females belonging to the underprivileged group of the society. since anemia is one of the causes of still child-birth, preterm and low birth weight babies causing cognitive disabilities during the later years of life, so, it needs to be treated on priority bases.

mal-nutrition is a significant problem in the developing world, with serious consequences for human health and socio-economic development. it is estimated that over 43% women of reproductive age suffer from anemia. in pakistan, about 35% non-pregnant and 51% pregnant women are suffering from anemia. prevention and control against anemia rely on iron supplementation and food fortification on large scale. both these methods are not affordable and feasible for poor people. previous studies have shown that about 97% females do not meet their iron requirements. the possible reason to this can be iron losses from body including menstruation. to overcome these problems, culturally accepted, inexpensive and modified recipes were used to supply iron with addition of moringa oleifera leaves (rich and cheap source of iron). in the study 34 of ages between 13-30 years were selected (excluding pregnant and lactating women) and were intervened with value added supplement " moringa oleifera" for a period of three months. these recipes were made part of the diet by giving a dose of three meals per day on regular basis. each recipe contained about 15 g of dried moringa powder. after the intervention, out of total 34, 3 females achieved normal hb level of 12 g/dl. overall, 94% cases of the study showed improvement of 1.8 g/dl (on average) in hb level after intervention. there was a significant increase in blood hb level (p\<0.000) and both the var5iables were strongly and positively correlated (0.928). variables of age and levels of education were weakly but significantly related to each other (p\<0.001) in improving hb after intervention. females with higher levels of education showed better response towards intervention. after intervention with moringa oleifera, an average increase of 1.5 g/dl in hb was observed in the entire population whereas, members of group b (ages above 18) showed more increase of 14.96% in their hb level as compared to members of group a (ages below 18) showing an increase of 12.96% in hb level.

Eligibility criteria:
inclusion criteria: * reproductive aged females (13-30 years) exclusion criteria: * pregnant and lactating women

Keywords: hb, anemia,
the effect of positive end expiratory pressure on central venous pressure among patients with different lung compliance

Conditions: Sepsis; ARDS; Traumatic Brain Injury

Summary: to observe the effect of peep on cvp among patients with different respiratory compliance

30 patients with mechanical ventilation and inserted central venous line will be entered. after gathering demographic data, patients undergone 5,10 and 15cmh2o peeps and the respective cvps of the mentioned points will be recorded. according to the change of cvp, the patients will be divided into high response group and low response group, then comparing the lung compliance and thorax elastic resistance differences between the two groups.

Eligibility criteria:
inclusion criteria: 1. patients with mechanical ventilation and inserted central venous line exclusion criteria: 1. the age is less than 18 years old or more than 80 years old； 2. pregnant and lying-in woman； 3. patients undergoing fluid resuscitation and the speed is more than 200ml/h； 4. patients with norepinephrine dose are greater than 15 micro per minute； 5. patients with pericarditis、pulmonary heart disease、right heart failure、atrial fibrillation； 6. patients with copd(endogenous peep is more than 2cmh2o)、tension pneumonthorax、acute episode asthma