Kornimate/medical-research-clean huggingface dataset:
comparative study of epigastric pain syndrome and postprandial distress syndrome

Conditions: Functional Dyspepsia; Epigastric Pain Syndrome; Post Prandial Distress Syndrome

Summary: the purpose of this study is to compare postprandial distress syndrome and epigastric pain syndrome in demographics psychological features, infection of helicobacter pylori, gastric emptying and therapeutic response to lansoprazole.

functional dyspepsia is a common clinical disorder with significant impact on quality of life and with enormous social cost. previous studies have revealed that functional dyspepsia is not a homogenous disease but a heterogenous symptom complex. because of heterogeneity in etiology and pathogenesis, no specific treatment is appropriate for all patients with functional dyspepsia. currently available treatments demonstrated efficacy only in subsets of patients. appropriate subgrouping of functional dyspepsia, which categorizes more homogenous patients into the same group, will correlate better with specific etiologic factors and pathogenetic mechanisms. consequently patients may have appropriate specific treatment based on more directed pathologenesis and subgrouping. to this end, american gastroenterology association launched new edition of clinical guide for functional gastrointestinal disorder, the rome iii in may 2006. the new diagnostic criteria of rome iii de-emphasized functional dyspepsia as an entity and recommended sub-classification into two conditions: postprandial distress syndrome and epigastric pain syndrome. however whether this new diagnostic criteria and systems are effective and clinically relevant remains unknown. aims: we aim to compare postprandial distress syndrome and epigastric pain syndrome in demographics psychological features, infection of helicobacter pylori, gastric emptying and therapeutic response to lansoprazole.

Eligibility criteria:
inclusion criteria: * aged greater than 20 years * fulfill rome iii diagnostic criteria exclusion criteria: * children and teenagers aged less than 20 years * organic lesions such as ulcers, tumors, bleeding, vasculopathy or esophagitis as demonstrated on upper endoscopy * concurrent illness with malignancy, diabetes mellitus, liver cirrhosis, renal failure or porphyria * diagnosis of organic disease for dyspeptic symptoms by treating physicians * history of abdominal surgery * concurrent user of aspirin and nsaid * history of allergy or severe side effects to lansoparzole * pregnant or lactating women

Keywords: functional dyspepsia gastric emptying helicobacter pylori lansoprazole epigastric pain syndrome postprandial distress syndrome
zip® surgical skin closure device vs. staples for skin closure in subjects having undergone bilateral knee arthroplasty

Conditions: Arthroplasty, Knee Replacement; Wound Healing

Summary: study designed to compare the zip surgical skin closure device vs. conventional staples for wound closure following bi lateral knee replacement surgery.

prospective, randomized, within patient control study comparing the use of zip surgical skin closure device versus conventional staple placement when utilized for surgical wound closure after bi lateral unicompartmental or bi lateral total knee replacement. a total of up to 25 patients will be enrolled and followed for up to 8 weeks post surgery to evaluate wound healing and overall satisfaction of closure method.

Eligibility criteria:
inclusion criteria: 1. patients 18 years of age and older 2. patients requiring epidermal closure after bi lateral total or partial (unicompartmental) knee arthroplasty 3. patients willing to be evaluated at discharge, 2 weeks, and at the 6 to 8 week post op exclusion criteria: 1. known bleeding disorder not caused by medication 2. known personal or family history of keloid formation or scar hypertrophy 3. known allergy or hypersensitivity to non-latex skin adhesives 4. atrophic skin deemed clinically prone to blistering 5. any skin disorder affecting wound healing 6. any other condition that in the opinion of the investigator would make a particular patient unsuitable for this study

Keywords: bi lateral knee surgery arthroplasty orthopedics
astral vaps autoepap clinical trial

Conditions: Upper Airway Obstruction; Respiratory Insufficiency; Respiratory Failure

Summary: patients with chronic respiratory failure such as those associated with chronic obstructive pulmonary disease (copd), obesity hypoventilation syndrome (ohs), obstructive sleep apnea (osa) or neuromuscular disease (nmd) are increasingly managed with domiciliary non-invasive positive pressure ventilation (nippv). the aim of this study is to now compare the automatic expiratory positive airway pressure (autoepap) algorithm with a fixed manual epap in ivaps mode on an astral mixed mode ventilator. it is proposed that the automatic settings of autoepap will be as effective at managing respiratory failure and upper airway obstruction (uao) as manual epap on the astral device. specifically demonstrating that the autoepap function is as effective at treating uao as manual epap.


Eligibility criteria:
inclusion criteria for the study are: 1. participant has ability to provide written informed consent 2. participants aged ≥18 years old 3. participant has documented respiratory failure (e.g. sleep hypoventilation with historical ptco2 increase ≥ 10mmhg) and/or daytime hypercapnia (\>45 mmhg) 4. participant is currently using non-invasive positive pressure ventilation in st or vaps mode for ≥ 3 months 5. participants with a previously documented ahi ≥ 5/hr 6. participants with a recently (≤ 12 months ago) reviewed epap setting exclusion criteria for the study are: 1. participants are not compliant on nippv (e.g. \< 4 hr/night) 2. participants who are pregnant 3. participants on oxygen therapy ≥5 l/min 4. participants with an invasive interface (e.g. tracheostomy) 5. participants who have had an acute exacerbation within the last 3 months that resulted in a hospitalisation 6. participants who are acutely ill, medically complicated or who are medically unstable 7. participants in whom nippv therapy is otherwise medically contraindicated 8. participants who have had surgery of the upper airway, nose, sinus, or middle ear within the previous 90 days 9. participants with untreated, non-osa sleep disorders, including but not limited to; insomnia, periodic limb movement syndrome, or restless legs syndrome. 10. participants who have the following pre-existing conditions: severe bullous lung disease, recurrent pneumothorax or pneumomediastinum, cerebrospinal fluid leak, recent cranial surgery or trauma. 11. participant does not comprehend english 12. participant is unable or unwilling to provide written informed consent 13. participant is physically and/or mentally unable to comply with the protocol 14. participant is not suitable to participate in the trial for any other reason in the opinion of the investigator

Keywords: niv, nippv, ventilation
comparison of laparoscopic to vaginal surgical repair for uterine prolapse

Conditions: Uterine Prolapse

Summary: investigators intend to conduct a prospective randomized trial to compare vaginal hysterectomy with uterosacral colposuspension to laparoscopic supracervical hysterectomy with sacrocervicopexy. both surgeries are minimally-invasive surgical standards of care for uterine prolapse repair. nobody knows if one procedure is superior to the other, as they have not been compared directly. the investigators hypothesize that there is no difference in objective, subjective, or cost-effectiveness between the two procedures for up to two years after surgery.


Eligibility criteria:
inclusion criteria: * patients with primary symptomatic uterine prolapse * ≥ 18 years of age * considering pelvic reconstructive surgery exclusion criteria: * unwillingness to be randomized to one of two surgical approaches * pregnant or planning to maintain their future fertility * unable to have general anesthesia * currently undergoing chemotherapy or has current or history of pelvic radiation * previous adverse reaction to synthetic mesh * recent history of abnormal paps (past 10 years) * cervical or uterine cancers * previous hysterectomy * previous central vault or uterine prolapse repair * uterus ≥ 14 weeks size * uterine cancer * history of significant pelvic adhesive disease * elongated cervix (length d to c \> 6cm) * fibroid ≥ 7cm * post menopausal with enlarged uterus

Keywords: uterine prolapse laparoscopy hysterectomy, vaginal
the effect of prenatal vitamins on the tooth structure

Conditions: Dental Caries

Summary: the effect of mother prenatal care on the teeth of the newborn children, if it affect the tooth structure or not

teeth lost due to normal shedding will be collected,it will be classified into mother that take pregnancy vitamins and mother that doesn't take pregnancy vitamins, the female will be from the same population and from the same city to make sure that the environmental condition are almost the same .teeth will be subjected to elementary analysis to determine the different ratio of different component and if there is any change between the two group

Eligibility criteria:
inclusion criteria teeth lost due to normal shedding sound teeth with non hereditary conditions normal children mother that don not suffer from chronic illness ex: diabetes exclusion criteria: * teeth extracted due to caries or trauma teeth with hereditary anomalies ex: hypoplasia
a registry study on xiyanping(a chinese medicine injection) used in fifty hospitals

Conditions: Viral Pneumonia; Bronchitis; Infantile Diarrhea; Bacillary Dysentery; Virus Hepatitis

Summary: this study was advocated by institute of basic research in clinical medicine, china academy of chinese medical sciences in october 2011. it was funded by china major scientific and technological specialized project for 'significant new formulation of new drugs'. xiyanping is kind of chinese medicine injection used for treating viral pneumonia 、bronchitis、amygdalitis、infantile diarrhea、bacillary dysentery 、virus hepatitis、and children acute hot diseases in many chinese hospitals. the purpose of this study is to determine adverse drug events or adverse drug reaction in large sample size 20,000 patients.

it is very common that chinese medicine injection used in hospitals in mainland china. however safety problems rose in recent years. there could be many uncertain factors influence chinese medicine injection in clinical practice. in order to ensure the safety of public drug use and lower drug-induced risks, a registry study for xiyanping injection safety surveillance with 20000 patients will be conducted from jan.2012 to dec.2015. eligibility criteria patients who will use xiyanping injection in selected hospitals.

Eligibility criteria:
inclusion criteria: * xiyanping injection from 2012 to 2014
the effect of laughter yoga on stress, burnout, and general health in psychiatric nurses

Conditions: Burnout; Perceived Stress; Occupational Stress; General Health; Psychiatric Nursing

Summary: this study aims to examine the effects of laughter yoga on general health, perceived stress, and burnout among psychiatric nurses. nurses working in psychiatric units are often exposed to high levels of occupational stress, which may impact their well-being and job performance. this trial was designed to evaluate the potential benefits of laughter yoga as a supportive intervention in this context.

psychiatric nurses frequently face emotionally intense situations, aggressive patient behaviors, and heavy workloads. these factors are known to contribute to elevated stress levels and burnout. this study was conducted as a randomized controlled trial at a psychiatric hospital located on the anatolian side of istanbul, türkiye. a total of 70 psychiatric nurses voluntarily participated and were randomly assigned to either an experimental group or a control group (n=35 per group). the experimental group received an eight-session laughter yoga program, with each session lasting approximately 30 minutes. sessions were held face-to-face in small groups and facilitated by a trained laughter yoga instructor. each session included four components: warm-up and clapping exercises, deep breathing, childlike playfulness, and structured laughter activities. the control group received no intervention during the study period. data were collected before and after the intervention using the following validated tools: nurse demographic information form maslach burnout inventory (mbi) perceived stress scale (pss-10) general health questionnaire (ghq-28) the study was approved by the relevant ethics committee, and all participants provided informed consent prior to enrollment.

Eligibility criteria:
inclusion criteria: * being a psychiatric nurse at the specified hospital * volunteering to participate * not receiving psychiatric treatment currently exclusion criteria: * chronic physical illnesses that could interfere * inability to attend all sessions

Keywords: laughter yoga maslach burnout inventory pss-10 ghq-28 psychiatric nurses nursing interventions mental health promotion complementary therapies burnout prevention stress reduction workplace wellness
correlation between qnox and analgesia nociception index (ani) values during general anesthesia

Conditions: Analgesia

Summary: qnox and ani are two indexes evaluting the analgesia conduction during general anesthesia. no trials have compared them, so with this trial authors want to explore the correlations between them.

qnox and ani are two indexes evaluting the anaglesia conduction during general anesthesia. even if the aim is the same (to measure the nociception level) these indexes utilize different algorithm: the qnox is derived by the electroencephalogrm (eeg), the ani is derived by heart rate variation. no trials have compared them, so with this trial authors want to explore the correlations between them, and if altered values of one of them is stronger related to postoperative pain and delirium.

Eligibility criteria:
inclusion criteria: * undergo general anaesthesia with targeted controlled infusion of propofol (eleveld model) and remifentanil (eleveld model) exclusion criteria: * neurological disease * psychiatric disease * obesity * regional anesthesia performed
a study to investigate the safety, tolerability, and pharmacokinetics of pf-06649751 in subjects with idiopathic parkinson's disease

Conditions: Idiopathic Parkinson Disease

Summary: this is a study with two sequential cohorts, each with three treatment periods. single doses of pf-06649751 will be tested in this study, starting at a low dose and escalating to a dose projected to be under the current limits for drug concentration. each cohort will aim to achieve approximately 9 completers. primary endpoint is safety and tolerability, secondary endpoint is mds-updrs part iii.


Eligibility criteria:
inclusion criteria: * l-dopa-responsiveness * hoehn \& yahr stage ii-iii inclusive * experiencing motor fluctuations * stable daily dose of l-dopa of at least 300 mg * females on non-childbearing potential and male subjects exclusion criteria: * history of troublesome dyskinesias * history of surgical intervention for parkinson's disease

Keywords: pakinson's disease, movement disorders
low-cost handgrip dynamometer in healthy adults

Conditions: Healthy; Hand Grip Strength

Summary: the gold standard device for measuring grip strength is the jamar® hydraulic hand dynamometer. the jamar® hydraulic hand dynamometer is a high-priced device. it has an analog reading feature. the jamar hydraulic hand dynamometer is recommended by the american association of hand therapists and is considered the gold standard because of its high validity and reliability. due to its cost, the use of this dynamometer is quite limited in certain countries and settings. however, there is a new version, the jamar plus+, which has a digital reading feature. this version is even more expensive. in recent years, the use of less expensive dynamometers for measuring grip strength has become increasingly common in clinical settings and scientific research. in particular, the camry dynamometer, which is ten times cheaper, is frequently used. despite its frequent use in scientific research, a review of the current literature has shown that the validity and reliability of the camry has not been examined in healthy populations. our study compares the jamar® hydraulic hand dynamometer, the gold standard device for measuring grip strength, with the lower cost and lighter handheld digital camry dynamometer.


Eligibility criteria:
inclusion criteria: * healty volunteers with 18-65 years exclusion criteria: * using any assistive device, * having rheumatoid arthritis, gout, neuromuscular disease or any acute/chronic disease that may affect grip strength, * pregnancy, * previous subluxation, dislocation or fracture in the upper extremity, * type 1 or type 2 dm, * unstable chronic and systemic diseases

Keywords: dynamometer
general or regional anesthesia for hip surgery

Conditions: Osteoarthritis

Summary: the purpose of this study is to determine whether general anaesthesia or regional anaesthesia is best for patients undergoing total hip arthroplasty.

a randomized controlled trial (rct) with a follow up time of 48 hrs. patients scheduled for primary total hip arthroplasty. a total of 120 patients randomly assigned to one of the two alternatives (general anaesthesia (ga) or regional anaesthesia (ra)). general anaesthesia compared to intrathecal anaesthesia will give shorter length of hospital stay (los) for patients undergoing total hip arthroplasty (tha). primary endpoint: los. secondary endpoints: postoperative pain? postoperative orthostatic function (dizziness) time until the patient meets the discharge criteria from pacu how many patients will need at least one urinary bladder catheterisation

Eligibility criteria:
inclusion criteria: patients with osteoarthritis scheduled for surgery * patients that will require tha * patients over 45 yrs and under 85 yrs. * patients that understand the given information and are willing to participate in this study * patients who have signed the informed consent document. * patients belonging to asa class i-iii. exclusion criteria: * prior surgery to the same hip * patients with a history of stroke, neurological or psychiatric disease that potentially could affect the perception of pain * obesity (bmi \> 35) * active or suspected infection * patients taking opioids or steroids * patients suffering from rheumatoid arthritis or an immunological depression * patients who are allergic to any of the drugs being used in this study

Keywords: anaesthetic techniques subarachnoid analgesia
adynovate drug use-results survey

Conditions: Hemophilia A

Summary: the purpose of this survey is to understand the following items in the actual clinical use of adynovate in patients: 1. unexpected adverse drug reactions 2. occurrence of adverse drug reactions in the actual clinical use 3. factors that may affect safety and efficacy 4. occurrence of factor viii inhibitor development in patients with coagulation factor viii deficiency (hereinafter hemophilia a) 5. safety and efficacy for hemophilia a patients who received routine prophylactic therapy and on-demand therapy


Eligibility criteria:
inclusion criteria: * hemophilia a patients who receive adynovate, including previously treated patients with factor viii deficiency (ptps), and previously untreated patients with factor viii deficiency (pups) who are treated with adynovate. exclusion criteria: * patients not administered adynovate.
rehabilitation of early stroke patients using an afo: an rct

Conditions: Stroke; Hemiplegia

Summary: stroke is a major cause of disabilities worldwide. stroke survivors commonly exhibit walking defects which lead to an altered, slow speed and asymmetric gait pattern. the main aims of rehabilitation are to enhance recovery of movement control and regain walking ability. ankle-foot orthoses (afos), braces which encompass the foot and ankle joint extending to a point below the knee, are commonly prescribed to address ambulation impairments in stroke patients. their main function is to support the foot and allow a subject to walk safely with a gait approaching normality. this project will aim to evaluate the early provision of afos as an adjunct to standard physiotherapy on the walking ability of stroke survivors. usual rehabilitation practice will be the control condition. participants will be recruited from the stroke unit of stobhill hospital in glasgow. they will be randomised into two groups. participants allocated in the control group will receive usual clinical practice as per routine for stroke patients. the intervention group will receive custom made solid afos as an adjunct. they will be provided with three afos, one for use during rehabilitation and two which will be used only during the outcome assessment sessions for research purposes. the intervention phase will last 24 weeks. gait analysis will be performed three times for each participant (at baseline, 12 and 24 weeks after enrolment) in the biomechanical laboratory of strathclyde university. during these sessions force and movement data of patients walking will be recorded. fortnightly time and distance factors of gait will be measured and a battery of functional tasks will be performed in the physiotherapy gym of the hospital using a simple video camera and a grid lino-mat. during all assessments participants with an afo will be asked to walk with and without the afo provided.


Eligibility criteria:
inclusion criteria: * 7 days to 8 weeks after ischemic or haemorrhagic stroke, medically stable, age range between 18 and 90 years, gastrocnemius shortening with plantarflexion contracture (5 degrees of plantarflexion or greater), capable of full correction of subtalar joint, no loss of skin integrity over the lower limb, no severe cognitive impairments, sufficient communication to follow the instructions in the trial data collection procedures (follow a single one step command). exclusion criteria: * inability to follow simple instructions or to give informed consent, unstable angina, cardiac risks, pain related to walking, severe spasticity, the need for two assistants while walking, severe proprioceptive sensory impairment, soleus contracture which prevents casting for the afo at 90 degrees , flexion contracture of hip musculature (greater than 10 degrees hip flexion).

Keywords: stroke ankle foot orthosis walking speed gait rehabilitation hemiplegia
a study to assess etoricoxib versus diclofenac in chinese patients with osteoarthritis of the knee or hip (0663-080)(completed)

Conditions: Osteoarthritis

Summary: a study to assess etoricoxib versus diclofenac in chinese patients with osteoarthritis of the knee or hip


Eligibility criteria:
inclusion criteria: * chinese males or females at least 40 years of age with osteoarthritis of the knee or hip

Keywords: arcoxia
the differential impact of proton beam irradiation versus conventional radiation on organs-at-risk in stage ii-iii breast cancer patients

Conditions: Breast Cancer Stage II; Breast Cancer Stage III

Summary: the objective of the study is to serve as a correlative study for patients enrolled on the radcomp trial (nct02603341), a randomized phase iii study of stage ii and iii breast cancer patients treated with either conventional photon radiation or proton beam radiation


Eligibility criteria:
inclusion criteria: * eligible for and scheduled to receive radiation therapy on radiation therapy oncology group (rtog) trial 3510 (pragmatic phase iii randomized trial of proton vs photon therapy for patients with non-metastatic breast cancer receiving comprehensive nodal radiation: a radiotherapy comparative effectiveness (radcomp) consortium trial). (nct02603341) * ability to understand and the willingness to sign a study-specific written informed consent document exclusion criteria: * there are no exclusion criteria.