Kornimate/medical-research-clean huggingface dataset:
evaluation of some parameters in university students during the covi̇d-19 epidemic process

Conditions: Health Behavior; Sleep; Body Weight

Summary: the physical and mental effects of the covid-19 pandemic have been examined by many researchers, but this study aims to evaluate in every aspect how university students who had to receive education with the distance education model due to the pandemic went through this process. data regarding people's positive and negative habits from anthropometric characteristics and sleep quality, which is one of the sub-dimensions of healthy lifestyle behaviors, were evaluated, and the relationship between these parameters was examined in detail.

this study focuses on distance education, remote working, etc. during the pandemic period. it is compatible with the findings of studies on the subject and reveals that the nutrition and physical activity sub-parameters of the healthy lifestyle behaviors scale are related to anthropometric characteristics and sleep quality. considering that the online working model has become widespread, from this perspective, for future studies, the effects of behavioral change strategies on individuals' sleep quality and anthropometric values can be investigated.

Eligibility criteria:
inclusion criteria: * students who are registered to kırklareli university faculty of health sciences and aged 18 years and older who agreed to participate in the study * those who are capable of filling out surveys online * those with internet access * with the fully answered to the questionnaire and scale questions exclusion criteria: * students who are not registered to kırklareli university faculty of health sciences
in-vivo wear behaviour of as coated versus uncoated columbus® total knee prosthesis

Conditions: Knee Arthritis; Knee Osteoarthritis; Primary Osteoarthritis of Knee Nos; Secondary Osteoarthritis of Knee Nos; Rheumatoid Arthritis of Knee; Instability, Joint; Osteonecrosis; Deformity Knee

Summary: this clinical study is a post-market clinical follow-up (pmcf) measure and is aiming to compare the in-vivo wear behaviour of the columbus® total knee prosthesis between the standard cobalt chromium (cocr) and the multilayer coated so called "advanced surface" (as) of the same implant. the clinical investigation is designed as a international, prospective, longterm non-interventional study in order to gain clinical data of many patients within the routine clinical application of the investigational device.


Eligibility criteria:
inclusion criteria: * indication for a primary bicondylar total knee endoprosthesis with the columbus® dd knee prosthesis * written signed informed consent of patient * willingness and mental ability to participate at the long-term follow-up examinations exclusion criteria: * pregnancy * patient age \ 75years * acute inflammatory arthritis * coagulation disorders (e.g. haemophilia)

Keywords: total knee arthroplasty implant wear advanced surface
evaluation of the mechanisms of weight-bearing of the hemiplegic limb during table tennis sessions in the framework of post-stroke rehabilitation : pilot study

Conditions: Post-stroke; Hemiplegic Gait; Rehabilitation

Summary: this is an experimental, observational, prospective study designed to develop medical knowledge. the primary objective of the study is to analyze the weight bearing of the hemiplegic side according to the different areas of interest during the practice of table tennis. this study is part of a usual framework of management of post-stroke hemiplegic patients with an additional passage to the movement laboratory to collect additional data collection, via the use of force plateforms, considered here as non-interventional. the passage to the movement laboratory consists in the practice of a table tennis session including three game situations. before to the table tennis session, the subject placed on the force plateforms, performs a spontaneous bipodal station followed by a maximum voluntary support transfer on the hemiplegic limb. during the table tennis session, the subject is filmed and his load on the hemiplegic side during the game situations is evaluated using the force platforms. in addition of the table tennis session three questionnaires are administered to the patient in order to know : * the static and dynamic balance in order to identify persons at risk of falling: berg balance and evaluation scale * the degree of autonomy of the patient: modified rankin score * the stroke severity: nihss score


Eligibility criteria:
inclusion criteria: * patients treated at the hopale foundation for a stroke rehabilitation program * patients following the balance and coordination protocol - minimum age of 18 years * berg score \>40 * subject has played table tennis at least once prior to the stroke. * patient is a member or beneficiary of a social security plan. * patient who has received informed information about the study and has given his/her consent * ability to understand french instructions. exclusion criteria: * cognitive disorders notified in the medical file * subject under judicial protection : * subject under guardianship * subject under curatorship * subject under protective measure * pregnant or breastfeeding woman * patient with cognitive disorders preventing the comprehension of instructions
utility of pharmacogenomics for reducing adverse drug effects

Conditions: Genetics of Drug Metabolism

Summary: upgrade aims to see whether data from pharmacogenomic testing (pgx) can help physicians manage patient medication regimens and assess if the testing has an effect on reducing adverse drug reactions, hospitalizations and emergency department visits. the way an individual processes a drug is in part determined by their genes, and there is known to be genetic variation between humans in the way drugs are metabolized. the study of the way genes affect a person's response to drugs is known as "pharmacogenomics."


Eligibility criteria:
inclusion criteria: * subject plans to undergo current index pgx testing at the time of enrollment or underwent current index pgx testing within the prior 1-year period, for genes known to influence metabolism of at least one target drug * subject is aged ≥18 years * subject is able and willing to provide written informed consent * subject reveals a history of at least one tdae or an inadequate therapeutic effect from a target drug over the 12-month period preceding expected receipt of pgx test results * subject is not taking an investigational medication or in an interventional trial that would interfere with participation in the registry exclusion criteria: * subject is currently hospitalized * subject's medical and medication history is unavailable over the 90-day periods preceding and following the receipt of pharmacogenomic test results * subject is unable to provide an accurate history due to mental incapacity * subject is known to have undergone prior pharmacogenomic testing (exclusive of the current index pgx testing) for genes specific to the target drugs within the 2-year period preceding enrollment and these results have been previously evaluated

Keywords: pharmacogenomics target drug related adverse events (tdae)
tapp and open repair for recurrent inguinal hernia

Conditions: Recurrent Inguinal Hernia

Summary: the objective of this study was to explore the clinical efficacy of transabdominal preperitoneal approach (tapp) and open tension-free hernia repair in the treatment of recurrent inguinal hernia. this study aims to provide a basis for selecting the optimal treatment methods for recurrent hernias.

the patients were randomly allocated to the tapp group and the open tension-free repair group. we recorded the general situation, operation time, and intraoperative complications; postoperative visual analogue pain scale (vas) scores at 24 and 48 h; and the incidence of complications such as seroma, chronic pain, inguinal numbness, foreign body sensation, and recurrence at 1 week, 1 month, 3 months, 6 months and 1 year after surgery. these indicators were compared between the two groups of patients.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * the diagnosis of recurrent inguinal hernia made by ultrasound or computed tomography (ct) during the present visit * ability to tolerate general anesthesia and local anesthesia surgery * all patients and their families agreed to participate in this study and sign relevant informed consent. exclusion criteria: * patch infection during the first surgery * multiple (≥ 2) relapses * inability to cooperate to complete follow-up after surgery
mhealth mindfulness intervention for pregnant black and latina women at risk of postpartum depression

Conditions: Post Partum Depression; Perinatal Depression

Summary: postpartum depression (ppd) is associated with significant health consequences for mothers and children, and the current covid-19 pandemic has had a major impact on the mental health of particularly vulnerable populations including pregnant black and latina women. there is an urgent need for evidence-based, accessible, and scalable mental health care options for these high-risk, vulnerable women. this study aims to: (a) compare the effectiveness of two digitally-delivered self-paced stress reduction programs in pregnant black and latina women at increased risk of ppd; and (b) examine barriers and facilitators to implementation within a large healthcare system.


Eligibility criteria:
inclusion criteria: * women seeking prenatal care at kpnc * identify as black or latina * current prenatal phq-9 score 10-19 * gestational age \<30 weeks * owns a smartphone or computer with internet access * english- or spanish-speaking exclusion criteria: * regular (3 times per week or more) stress reduction practice * cognitively impaired * deaf
supragingival plaque removal with and without dentifrice

Conditions: Dental Plaque

Summary: purpose: the aim of this study was to compare the efficacy of dental biofilm removal by brushing with and without conventional toothpaste. settings and design: twenty-four students aged 17 to 28 years old participated in this randomized clinical trial. materials and methods: quadrants 1-3 or 2-4 were randomly allocated to the test group (brushing without dentifrice) or control group (brushing with dentifrice). after 72 hours of cessation of oral hygiene, quigley \& hein (turesky) plaque index was assessed before and after brushing by a calibrated and blind examiner. overtime and intergroup comparisons were performed by paired sample t test.


Eligibility criteria:
inclusion criteria: * students of both genders systemically healthy. exclusion criteria: * individuals who exhibited gingivitis (presence of gingival bleeding at any site); * probing depth \> 3mm and/or attachment loss \>3mm at any site; * using orthodontic appliance devices, dental prostheses, dental implants; * presence of abrasions, restorations and/or carious lesions at cervical region; * individuals who had less than 20 natural teeth.

Keywords: toothbrushing dental plaque dentifrice oral hygiene
assessment of potential interactions between methamphetamine and selegiline - 1

Conditions: Amphetamine-Related Disorders

Summary: the purpose of this study is to assess the potential interactions between intravenous methamphetamine and oral selegiline.

to determine the safety of the selegiline concurrent with d-methamphetamine challenges of 15mg \& 30mg i.v. with the focus being on cardiovascular responses (hr,bp) to the i.v. methamphetamine challenges. this is a randomized, single-blind, placebo-controlled, two-arm study design to evaluate the safety of selegiline treatment, compared to placebo treatment, concurrent with i.v. methamphetamine challenges.

Eligibility criteria:
inclusion criteria: * volunteers who meet dsm-4 criteria for methamphetamine abuse or dependence; non-treatment seeking individuals * be able to verbalize understanding of consent form; provide written informed consent exclusion criteria: * please contact site for more information
using pleural effusions to diagnose cancer

Conditions: Pleural Effusion

Summary: pleural effusions (pe) are common conditions that signal either infection or cancer. the investigators aim to develop, validate, and prospectively assess the maped score, a clinical score that predicts malignancy at admission. this tool will assist clinicians all over the world to rapidly assess the probability of an effusion being malignant within 4 hours of admission.

background: pleural effusions (pe) are common conditions that signal either pleural-disseminated infection or cancer. while these diagnoses bear tremendous importance for patients, they require invasive procurement of pleural tissues and/or cells and time. simple and rapid diagnostic markers of pleural malignancy at admission that streamline diagnostic and treatment efforts remain unidentified. objective: to develop, validate, and prospectively assess markers of malignancy of pe at admission. methods: a prospective cohort of patients with pe from different etiologies will be recruited stating on 11.21.2013 and prospectively ending on 11.21.2023. data will be collected within 4 hours of admission including history, chest x-ray, and blood and pleural fluid (pf) cell counts and basic biochemistry. pleural fluid and serum will be biobanked for future analyses. patients will sign informed consent forms. diagnosis will be confirmed using standard microbiology, cytology, histology, and imaging techniques. patients undiagnosed within a month will be excluded. variables will be entered into binary regression and receiver-operator analyses using malignancy as the target to develop the maped score, a clinical score that predicts malignancy at admission. maped will be retrospectively validated in separate published cohorts from the first therapeutic interventions in malignant effusion (time) 1-3 trials from oxford uk. data will be censored and analyzed three times, at 40-month intervals since study initiation.

Eligibility criteria:
inclusion criteria: * pleural effusion * hospital admission * no previous pleural procedure * age \> 18 years * no previous chemoradiotherapy * no antibiotic therapy during previous trimester * all history, chest x-ray, and pleural and blood cell counts and biochemistry entry data obtained within 4 hours after admission exclusion criteria: * no diagnosis at one month post-admission * no informed consent provided * age \< 18 years * history, chest x-ray, or pleural and blood cell counts and biochemistry entry data obtained later than 4 hours after admission

Keywords: malignant cancer simple bedside test rapid score widely available feasible
evaluation of the mbio combined syphilis/hiv point-of-care diagnostic test

Conditions: HIV; Syphilis

Summary: this is a diagnostic validation study for a combined syphilis/hiv test made by mbio diagnostics, inc (mbio, boulder, co, usa). although the mbio syphilis/hiv diagnostic platform is designed for use at point of care (poc), it is made to provide similar performance as reference standards. diagnosing hiv and syphilis accurately with a single poc test will save time for clinic health workers and technicians, reduce loss-to follow-up caused by lengthy delays for lab-based tests, and save costs by eliminating the need for multiple tests. for this study, the sensitivity and specificity of the mbio hiv/syphilis serology system point-of-care diagnostic test will be determined using reference tests performed under controlled laboratory conditions. for this, clients receiving routine care in the ancs at the new nyanza provincial general hospital (nnpgh) and kisumu district hospital (kdh) will be consented to provide blood for the proposed study. study volunteers will receive hiv and syphilis rapid tests provided as part of routine care, and will donate an additional blood for evaluating the mbio test against the reference tests in a laboratory setting. this study is an investigational prototype, not for product registration. the results from this study will be used to inform product development of a second iteration of the mbio device design. at the time that the device is ready to be registered, it will undergo another field evaluation at which time it will be submitted to the appropriate regulatory body. because the mbio device is an hiv test, the device would be submitted to national aids \& sti control program (nascop), which is the appropriate regulatory body for hiv tests in kenya.


Eligibility criteria:
inclusion criteria: * pregnant * attending her first routine anc visit and willing to undergo tests for hiv/syphilis * able and willing to legally consent for enrollment * able to demonstrate-comprehension of study details as they are explained in the consent process by passing all the test questions of understanding. the subject is only allowed two attempts at passing the test of understanding. exclusion criteria: * unwilling to provide written informed consent. * unable to legally consent (minor without guardian) * opt out of hiv or syphilis test * previously diagnosed with autoimmune disorder (lupus, lyme disease), as determined by client recollection or clinical record.

Keywords: hiv syphilis combination poc point-of-care mbio
effects of kombucha intervention on emotional distress and sleep quality in breast cancer survivors

Conditions: Distress, Emotional; Sleep

Summary: effects of kombucha intervention on emotional distress and sleep quality in breast cancer survivors.


Eligibility criteria:
inclusion criteria: * stage 0-iii breast cancer * no any cancer treatment in the following year * perceived emotional distress and poor sleep quality * agree to follow the protocol of this study exclusion criteria: * stage iv breast cancer * pregnant women * abnormal liver, kidney, gastric, internal , immune, sleep disorder, metabolic, psychic functions and need to take the prescription medications or medical treatments regularly * could not follow the protocol of this study
ob-gyn clinical validation study

Conditions: Obstetric Complication; GYN Disorders

Summary: this is a single-site study evaluating obstetrics and gynecology exam imaging quality by expert users.

six healthcare professionals with training and experience in obstetrics and gynecology ultrasound qualitatively assessed the image quality of the kosmos diagnostic ultrasound system compared to the benchmark mindray m9 ultrasound system. five sonographers were required to complete each scanning cohort of at least three gravid and three non-gravid participants. a sixth sonographer was added to the study to accommodate a scheduling conflict and provided additional image quality data outside of the five completed cohorts. the following views/structures were assessed for image quality: gynecology participants: * uterus * ovaries * endometrial cavity * cervix • obstetrics participants in their 1st trimester: * general image quality of the fetus * ability to visualize the crown rump length * visualization of gestational sac * visualization of yolk sac if present • obstetrics and participants in their 2nd trimester: * general image quality of the fetal structures * visualization of the amniotic fluid * visualization of the placenta * cardiac motion in 2d and m-mode with heart rate obstetrics and participants in their 3rd trimester: * general image quality of the fetal structures * visualization of the amniotic fluid * visualization of the placenta * visualization of the maternal cervix * cardiac motion in 2d and m-mode with heart rate * 3 vessel umbilical cord in 2d and color doppler the sonographers captured all views/structures on the mindray m9 ultrasound system, then switched over to the kosmos diagnostic ultrasound system to capture the same views/structures. once all views/structures were captured on both ultrasound systems, the healthcare professionals reviewed the images in parallel on each system, then provided a comparison score for kosmos between 1 and 7.

Eligibility criteria:
inclusion criteria: 1. persons able to: 1. read and sign an english consent form. 2. read and complete an english demographic and general health survey. 3. give consent for participation. 4. able and willing to comply with study requirements. 2. those aged 18 years through 40 years, healthy, particularly in respect to their pregnancy. 3. pregnant individuals who have received a previous ultrasound exam by their physician. exclusion criteria: 1. children (minors) under 18 years old. 2. adults over 40 years old. 3. those who cannot or refuse to sign their consent. 4. those who cannot provide informed consent. 5. vulnerable populations, i.e., individuals whose willingness to participate in the study could be unduly influenced by the expectation of medical benefits associated with participation. 6. vulnerable populations, i.e., individuals whose willingness to participate in the study could be unduly influenced by parents, employer or monetary benefit. 7. pregnant individuals who have not received a previous ultrasound exam by their physician. 8. individuals who have had a hysterectomy, oophorectomy, and trachelectomy.
clinical evaluation of the cochlear nucleus ci532 cochlear implant in adults

Conditions: Hearing Loss, Sensorineural

Summary: the purpose of this study is to gather long-term data on the fda approved ci532 cochlear implant, and cp1000 (nucleus 7) sound processor

appropriate candidates will receive a ci532 cochlear implant and be fit with the cp1000 sound processor. imaging will be completed pre-op, intra-op, and post-op to assess implant location. speech perception testing as well as subjective questionnaires will be administered over 12 months.

Eligibility criteria:
inclusion criteria: 1. adults 18 years or older who have a bilateral postlinguistic sensorineural hearing loss. 2. limited benefit from amplification as defined by test scores of 40% correct or less in the ear to be implanted and 50% or less in the contralateral ear on a recorded monosyllabic word test i. consistent with the minimum speech test battery (2011), it is required that all subjects be evaluated at 60 dba presentation level. 3. bilateral moderate sloping to profound hearing loss 4. minimum of 30 days experience with appropriately fit bilateral amplification, fit using the standardized national acoustics laboratory (nal) fitting method 5. proficient in english 6. ability to complete testing - exclusion criteria: 1. previous cochlear implantation 2. pre-linguistically deafened (onset of hearing loss at less than two years of age) 3. ossification or any other cochlear anomaly that might prevent complete insertion of the electrode array 4. duration of severe to profound hearing loss greater than 20 years 5. diagnosis of retro-cochlear pathology 6. diagnosis of auditory neuropathy 7. unrealistic expectations on the part of the subject regarding the possible benefits, risks, and limitations that are inherent to the surgical procedure and use of the prosthetic device 8. unwillingness or inability to comply with all investigational requirements 9. additional cognitive, medical or social handicaps that would prevent completion of all study requirements-

Keywords: cochlear implant, sound processor