Kornimate/medical-research-clean huggingface dataset:
adverse drug events at emergency department

Conditions: Adverse Drug Event

Summary: emergency departments (eds) are a crucial element of the health care systems at interface between hospital and communities. the goals of the ed are to make an initial diagnosis and deliver urgent and critical care 24 hour per day and 365 days a year. also, many adverse drug events (ades) are not identified by emergency physicians. ades are injuries resulting from a drug related medical intervention. their detection, documentation and reporting are essential for adequate medical care and knowledge of risk/benefit profiles of medication throughout their lifecycle. however, a number of studies indicate that in clinical practice the under-reporting of ades is a pervasive and widespread problem. the main reasons for under-reporting were difficulty in determining the cause of the ade, lack of time, poor integration of ade-reporting systems and uncertainty about reporting procedures. successful treatment of ades depends on the ability of physicians to attribute ades to a medication. some studies have reported that pharmacists but also student pharmacists were one of the best health care providers to establish medication history. consequently, the aims of our study were to assess prevalence and characteristics of ades identified in an emergency department and to identify factors associated with ades in ed patients. this prospective observational study is conducted at the ed of a tertiary care hospital (university hospital of montpellier). this department supports 80 000 patients every years. patient were not included if they were less than 18 years old, present acute psychological disturbance or they did not agree to participate at this study. for each patient included, a pharmaceutical team conducted: medication reconciliation process to establish medication history and a structured interviews to determine self-reported adherence and self-medication. ades were attributed to a medication by the treating senior emergency physician: directly during patient consultation or after being alerted by the pharmaceutical team.


Eligibility criteria:
inclusion criteria: - patients aged above 18 years old, admitted to the department during the study period exclusion criteria: - patient presenting acute psychological disturbance or they did not agree to participate at this study

Keywords: emergency department clinical pharmacist adverse drug event
herbal preparation used as adjuvant therapy on diabetic ulcers

Conditions: Diabetic Foot Ulcer; Amputation

Summary: chronic foot ulcers occurring among diabetic patients are difficult to heal. the frequent elderly age with co-morbidities, vascular insufficiencies, peripheral neuropathies and super imposed infections, all contribute towards the chronicity and failure of treatment. preserving the ulcerated limb is the patients' wish. on the other hand, an infected ulcer that never heals just unnecessarily prolongs suffering. nevertheless, patients earnestly like to try all methods of healing before accepting amputation. objective:to determine whether a course of herbal preparation used as an adjuvant therapy for diabetic patients suffering from chronic foot ulcers may promote healing so that major leg amputation can be avoided.


Eligibility criteria:
inclusion criteria: * well controlled diabetic state * presence of gangrene or non-healing ulcer in diabetic patients over the foot or feet. infection should be well controlled. * good glycaemic control exclusion criteria: * pregnant women and women at risk of conception * patients taking digitalis glycosides * patients with abnormal liver function tests * patients with plasma creatinine great then 150 umol/l or unstable renal function * poorly controlled diabetes mellitus * uncontrolled infection * history of adverse reaction to herbal medicine * unstable medical conditions * non-compliance with regime

Keywords: diabetic foot ulcer traditional chinese medicine
video exercise mobile application for people with knee osteoarthritis

Conditions: Telerehabilitation; Osteoarthritis, Knee

Summary: the aim of our study is to realize an exercise training and follow-up system that individuals with knee oa can easily adapt.


Eligibility criteria:
inclusion criteria: * diagnosis of primary knee osteoarthritis (oa) according to the american college of rheumatology (acr) criteria * be qualified to use the mobile application and agree to use the application exclusion criteria: * individuals with poor cognitive function or inadequate reading skills * individuals with neurological disorders that may affect mobility skills * individuals who have undergone knee joint surgery and individuals with traumatic injuries
social media intervention - physical activity

Conditions: Cannabis Use

Summary: the purpose of the study is to develop and test social media interventions to help young people increase well-being and reduce risky behaviors. the study will help us learn about ways to deliver wellness information in a way that is appealing and helpful to young people that use social media. eligible participants will be enrolled after baseline survey is completed. participants will be involved with the secret social media group they are assigned to for 8 weeks. in addition, surveys will be completed at various times during and after the 8 week social media group.


Eligibility criteria:
inclusion criteria: * self-report using cannabis at least 3 times per week or more often in the past month * active facebook profile exclusion criteria: * participants who cannot read english will be informally excluded * if participants fail identity verification based on: * internet protocol (ip) addresses * survey time completion * repeat attempts * survey responses * photo identification from a time stamped self picture sent to the research team * cannot safely engage in moderate to vigorous physical activity \[assessed at screening\] * participated in previous project verdi waves

Keywords: social media
investigating the bioequivalence of eptacog alfa a 6 mg and novoseven® in healthy male subjects

Conditions: Congenital Bleeding Disorder; Haemophilia A; Haemophilia A With Inhibitors; Haemophilia B; Haemophilia B With Inhibitors; Healthy

Summary: this trial is conducted in europe. the aim of the trial is to investigate the bioequivalence of eptacog alfa a 6 mg and novoseven® in healthy male subjects.


Eligibility criteria:
inclusion criteria: * male, age 18-55 years, both inclusive, at the time of signing informed consent * body mass index (bmi) 18.5-30 kg/m\^2, both inclusive * good general health based on assessment of medical history, vital signs, physical examination, ecg (electrocardiogram), and laboratory data at screening, as judged by the investigator exclusion criteria: * known history of thromboembolic event(s) or potential thromboembolic risk as judged by the investigator
modified anatomical mesh in the management of orbito-zygomatico-maxillary complex fractures

Conditions: Orbital Fractures; Zygomatic Fractures

Summary: orbito-zygomaticomaxillary-complex fractures is a form of a complex orbital floor fracture, with affection of the inferior orbital rim and the orbital walls. according to published research, between 67 - 84 % of periorbital bone fractures are orbital floor fractures. evaluation of 3d-modified anatomic mesh in the management of ozm- complex fractures with orbital floor defect, and compare it with the conventional fixation configuration.

patients suffering from ozm- complex fractures was treated using 3d-modified anatomical mesh for orbital floor reconstruction and orbital rim fixation. patients was randomly allocated into study and control groups, where it is managed with the conventional 2.0-miniplate and stock mesh. a standardized surgical protocol was followed in both groups. patients was clinically evaluated for pain, wound healing, nerve sensation, ocular motility and diplopia, and tarsal plate morphology. moreover, radiographic survey was performed post operatively to assess the proper positioning of the implant, to confirm proper fracture reduction, and radiographic enophthalmos analysis

Eligibility criteria:
inclusion criteria: 1. patients suffering from orbito-zygomaticomaxillary complex fractures with fracture in the orbital floor and orbital floor defect(16). 2. fractures that are indicated for open reduction and internal fixation. 3. patients suffering from ocular complications: 1. monocular diplopia. 2. enophthalmos above 2 mm. 3. restricted ocular motility. 4. patients with orbital wall defects with orbital soft tissue herniation into the maxillary sinus. 5. adult patient either male or female that agrees to present for follow-up visits for an adequate postoperative period. exclusion criteria: 1. patients with isolated orbital floor defects and blowout fractures. 2. patients with isolated zygomatico-maxillary complex fracture with no orbital floor/ walls defects. 3. patients with bilateral orbital defects. 4. patients with infected wounds in periorbital region. 5. medically compromised patients rendering them inoperable. 6. patients with ruptured globe or blindness.

Keywords: anatomical mesh 3d-mesh orbital mesh orbital fracture zygomatic fracture reconstruction
school- and home-based early intervention for toddlers with autism

Conditions: Autistic Disorder; Autism

Summary: this study will determine the impact of early intervention on the communication and social development of toddlers with autism.

autism is a condition that affects brain development, often leading to difficulties in social, emotional, and educational functioning. this study will determine whether early intervention can improve such functioning in toddlers with autism. each treatment session will last 6 months. children with an autism spectrum disorder will be enrolled in one of two parallel classes and will receive one of two treatments 4 days a week for the duration of the session. children in each class will receive the same amount and level of intervention, but with a different goal focus. treatments will be school- and home-based; parents will receive instruction on administering the at-home part of the treatment. the intervention will include environmental engineering, developmental approaches, adaptations of traditional behavioral approaches, and contemporary behavioral approaches that apply principles of applied behavior analysis in more naturalistic teaching frameworks. a series of measures including scales, interviews, and observations will be used to assess the children at baseline, study completion, and 6 months after study completion. the children will be videotaped during the school-based intervention.

Eligibility criteria:
inclusion criteria: * diagnosis of autism spectrum disorder * parent or guardian willing to give informed consent for child's participation * developmental level above 9 months on the visual reception scale of the mullen scales of early learning and on the adaptive behavior composite of the vineland adaptive behavior scales * english is primary language for child and family exclusion criteria: * evidence of vision or hearing impairment * diagnosis of fragile x syndrome, rett syndrome, tuberous sclerosis, neurofibromatosis, phenylketonuria, or congenital rubella * history of severe birth trauma or traumatic brain injury * siblings with autism spectrum disorder

Keywords: child
development and validation of a deep learning system for nasopharyngeal carcinoma using endoscopic images

Conditions: Nasopharyngeal Carcinoma

Summary: develop a deep learning algorithm via nasal endoscopic images from eight npc treatment centerto detect and screen nasopharyngeal carcinoma(npc).

nasopharyngeal carcinoma (npc) is an epithelial cancer derived from nasopharyngeal mucosa. nasal endoscopy is the conventional examination for npc screening. it is a major challenge for inexperienced endoscopists to accurately distinguish npc and other benign dieseases. in this study, we collcet multi-center endoscopic images and train a deep learning model to detect npc and indicate tumor location. then, the model perfomance will be compared with endoscopists and be tested prospectively with external dataset.

Eligibility criteria:
inclusion criteria: * the quality of endoscopic images should clinical acceptable. * patients were diagnosed with biopsy(npc, benign hyperplasia). control corhort(normal nasopharynx) don't require bispsy result. exclusion criteria: * images with spots from lens flares or stains, and overexposure were excluded from further analysis. * image can not expose most part of lesion clearly.

Keywords: nasopharyngeal carcinoma deep learning tumor screening
neurofeedback and nomophobia in young adults

Conditions: Anxiety; Biofeedback

Summary: introduction: given the growing increase in addiction to social networks and smartphone use in young people and its implications for health, it is necessary to investigate effective interventions for the appropriate use of these technologies and coping with possible signs of addiction. objective: to evaluate the effect of an intervention based on neurofeedback techniques on anxiety and other disorders associated with problematic use of mobile phones and the internet in young adults. methodology: randomised controlled clinical trial with two parallel groups: an intervention group (ig) and a control group (cg). the study population will be young adults aged 18-30 years. a sample size of 36 participants has been estimated, 18 in each group to detect a difference of 3.9 points or more on the dass-21 anxiety questionnaire. all participants will receive an educational workshop on the responsible use of new technologies and the promotion of healthy lifestyles. the ig, in addition to this educational workshop, will receive 20 neurofeedback sessions during 8 weeks, 2-3 sessions/week with the muse neurofeedback device. a baseline and 3-month post-intervention assessment will be conducted for both groups to study change variables related to smartphone addiction (smartphone addiction scale-short version (sas-sv)), nomophobia (nomophobia questionnaire (nmp-q)), depression, anxiety and stress (depression, anxiety and stress scale 21-item (dass-21)) and sleep quality.


Eligibility criteria:
inclusion criteria: * have one or more mobile devices such as smartphones. * have a compatible mobile device to install and use the muse: eeg meditation \& sleep application. * be fully functional. * willingness to voluntarily participate in the study and sign the informed consent form. exclusion criteria: * history of severe psychiatric disorders (such as schizoaffective disorders, bipolar disorder, major depressive episode with symptoms or other non-organic psychotic disorders) requiring psychiatric treatment in the 6 months prior to study entry. * history of brain injury or other problems contraindicating the use of neurofeedback.
infant pulse oximetry in pakistan study

Conditions: Hypoxemia; Neonatal Sepsis; Pneumonia

Summary: hypoxemia is an abnormally low concentration of oxygen in the blood, and is an important sign of cardio-respiratory compromise in acutely ill patients. pulse oximetry (po) is a rapid, portable, non-invasive and accurate method of measuring arterial hemoglobin oxygenation (sp02), and can therefore be readily implemented to detect hypoxemia in the clinical setting. in this research study, we propose to test the hypothesis that the use of pulse oximetry to detect hypoxemia by first-level health workers' in karachi, pakistan is useful and feasible for the identification of the infants most urgently in need of medical care. we will enroll 1,400 infants 0-59 days of age who present to one of two primary health centers in karachi. infants will undergo brief clinical assessment by a community health worker (chw) based on the who/unicef integrated management of neonatal and child illness (imnci) algorithm, assessment by two pulse oximetry devices, and examination by a physician. the primary outcomes include prevalence of hypoxemia, feasibility of po (e.g., time to obtain measurement, number of infants for who repeat measurements are required), and concordance between paired measurements on separate devices.


Eligibility criteria:
inclusion criteria: * infant presenting to the bilal or bhains phc in karachi, pakistan * age 0 - 59 days exclusion criteria: * clinic visit is for scheduled injectable antibiotic administration (e.g., sat trial)

Keywords: pulse oximetry pediatrics pakistan hypoxemia neonatal sepsis pneumonia
atezolizumab and pre-surgical brain radiation therapy for glioblastoma multiforme

Conditions: Glioblastoma Multiforme

Summary: this is a single-arm pilot study that will recruit 12 patients with newly diagnosed glioblastoma, a malignant brain tumor with a poor prognosis. patients will be treated with fractionated stereotactic radiotherapy (fsrt) for 2 weeks, in addition to two doses of atezolizumab (tecentriq), an fda approved pd- l1 inhibitor drug, 840 mg iv, at the beginning and at the end of the two-week time period, concomitantly with fsrt. after this initial two weeks treatment the patients will undergo craniotomy and maximal safe resection as per normal care for a gb. after surgery patients will follow the normal care for glioblastoma in addition to atezolizumab 840 mg iv q2 weeks for the duration of adjuvant treatment.


Eligibility criteria:
inclusion criteria: * diagnosis of glioblastoma multiforme who grade iv * the patient is a surgical candidate, with the surgical intent for a \> 80% resection of the lesion * negative pregnancy test * ecog status \<= 2 * tumor volume \<= 3.5 cm * adequate organ function * negative for infectious disease (human immunodeficiency virus, hepatitis b virus, hepatitis c virus, tubercolosis) exclusion criteria: * presence of leptomeningeal disease, gliomatosis cerebri, multifocal disease, bilateral cerebral hemisphere involvement ("butterfly" gliomas) * patients at increased risk of neurologic decompensation * continued use of high dose intravenous or oral corticosteroids, or \> 8milligrams per day of systemic dexamethasone * uncontrolled tumor-related pain * uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures (once monthly or more frequently) * uncontrolled or symptomatic hypercalcemia * history of autoimmune disease or immune deficiency * history of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, or idiopathic pneumonitis, or evidence of active pneumonitis * significant cardiovascular disease * history of other malignancy within 1 year prior to screening * severe infection within 4 weeks prior to initiation of study treatment * history of allogeneic stem cell or organ transplant * prior treatment with cd137 agonists or immune checkpoint blockade therapies * treatment with systemic immunostimulatory agents * treatment with systemic immunosuppressive medication
efficacy, safety, and tolerability study of sotagliflozin as adjunct therapy in adult patients with type 1 diabetes mellitus who have inadequate glycemic control with insulin therapy

Conditions: Type 1 Diabetes Mellitus

Summary: this phase 3 study was intended to demonstrate superiority of either sotagliflozin high dose or low dose versus placebo on glycosylated hemoglobin a1c (a1c) reduction at week 24 when used as an adjunct in adult participants with type 1 diabetes mellitus (t1d) who have inadequate glycemic control with insulin therapy.


Eligibility criteria:
inclusion criteria: * participant who gave written informed consent to participate in the study in accordance with local regulations. * adult participants 18 years and older with a diagnosis of t1d made at least 1 year prior to informed consent. * participants treated with insulin or insulin analog delivered via continuous subcutaneous insulin infusion (csii) or multiple daily injections (mdi). * willing and were able to perform self-monitoring of blood glucose (smbg) and completed the study diary as required per protocol. * at the screening visit, a1c was between 7.0% to 11.0%. * females of childbearing potential must use an adequate method of contraception and have a negative pregnancy test. exclusion criteria: * use of antidiabetic agent other than insulin or insulin analog at the time of screening. * use of sodium-glucose cotransporter (sglt) inhibitors within 8 weeks prior to screening. * chronic systemic corticosteroid use. * type 2 diabetes mellitus (t2dm), or severely uncontrolled t1d as determined by the investigator.

Keywords: high level of sugar (glucose) in the blood
intravenous lidocaine in carcinologic ent surgery: a trial for evaluation of opioid saving strategy and chronic post-surgical pain (elico)

Conditions: Carcinologic Ear, Nose, and Throat (ENT) Surgery

Summary: lidocaine, local anesthetic used for more than five decades, is being intravenously administered aiming at managing pain in different types of surgeries with promising results. opioid-induced hyperalgesia need to be considered in ear-nose-throat (ent) surgery owing to the difficulty of locoregional anesthesia and high level of opioid consumption. this randomized study aims to compare quality of perioperative analgesia after infusion of intravenous lidocaine during carcinological ent surgery. the main purpose of this study is to evaluate morphine consumption during the 48 postoperative hours. others purposes are evaluation of peroperative remifentanil consumption, morphine consumption during the 24 postoperative hours, chronic post-surgical pain evaluated from 3 to 6 months after carcinologic ent surgery, and incidence of side effects that can be attributed to lidocaine infusion.


Eligibility criteria:
inclusion criteria: * patient undergoing major carcinological ent surgery (total laryngectomy, oropharyngectomy with or without mandibulotomy, crico-hyoido-epiglotto-pexy, intraoral extended resection, partial laryngectomy, partial pharyngectomy, extended pelvectomy, pelviglossectomy, with or without pectoralis major flap or free flap, with or without lymphadenectomy) * patient receiving standardized patient controlled analgesia (pca) * written informed consent exclusion criteria: * hypersensitivity to local anesthetics of the amide group, * acute porphyria * atrioventricular conduction disorders requiring permanent electro-systolic * epilepsy not controlled by treatment * hepatocellular insufficiency (pt\<50%) or cirrhosis * systolic heart failure (lvef \<50%) * major inflation state * hypersensitivity to any component of glucose 5% * treatment with beta-blockers or antiarrhythmic of vaughan williams classification * bmi \> 30kg/m2 * patient already treated for chronic pain with level 3 analgesic or for neuropathic pain * pregnant or lactating women * refusal to give consent * patient under legal protection measure

Keywords: postoperative pain intravenous lidocaine chronic post-surgical pain remifentanil patient controlled analgesia morphine consumption ent surgery