Kornimate/medical-research-clean huggingface dataset:
efficacy of lappa arctium (homoeopathic medicine) in treatment of acne vulgaris

Conditions: Acne Vulgaris

Summary: acne is one of the most common skin problems in teenagers and adolescents. there are many lesser known homoeopathic medicines which have been mentioned in the literature for treatment of acne but their potential has not been properly assessed /documented and therefore these medicines don't form a part of many prescriptions. as a part of this study,efficacy of lappa arctium will be studied in the treatment of acne vulgaris


Eligibility criteria:
inclusion criteria: * males and females between 12 to 25 years of age * presence of inflammatory and non-inflammatory lesions * able to follow-up according to protocol * patients not taking any medication for treatment of acne in preceding one month. exclusion criteria: * acne conglobata * pregnant or breast feeding females or females having intention of becoming pregnant * significant systemic disease * any drug/ alcohol addiction * history of chronic diseases treated with medications in the preceding month which might affect acne condition and treatment outcome

Keywords: acne vulgaris homoeopathy lappa arctium
a machine learning approach for inferring alcohol intoxication levels from gait data

Conditions: Alcohol Drinking

Summary: this study aims to develop a phone app to assess gait differences at different levels of alcohol intoxication.

250 adult volunteers who will each participate in a single laboratory-based visit. at the orientation, each participant will provide informed consent, be weighed, and undergo a medical history to confirm eligibility. a urine drug quick-screen will be given. female participants will take a urine pregnancy test. baseline questionnaires will be administered. after giving participants the phone on which the alcogait 2.0 app is installed, baseline assessment of gait will be performed with the participant walking a distance of 50 yards ten times. drinking will then commence. the total amount will be consumed over 30 minutes. participants will have their brac assessed multiple times during and after drinking has commenced and finished. at brac levels of .02, .04, .06 and .08 g%, will perform the gait task. after the last gait task, participant data will be transmitted to a secure server. participants will receive a meal, and will be escorted to a sitting area with a dvr and videos, and allowed to use their own electronic devices. their brac will be periodically tested until it reaches .02 g% or below, then a taxi will be called to take them home.

Eligibility criteria:
inclusion criteria: * ages 21-65 * drinking at least 5 drinks per occasion for men (4 for women) during a single drinking episode at least once in the last month to ensure, for safety reasons, that people are accustomed to consuming alcohol in amounts comparable to what we will administer * willingness to drink beer (since only beer will be provided in the session to standardize drinks more easily). exclusion criteria: * past 6 months or current treatment for alcohol or drug abuse by self-report (for ethical reasons) * score \> 5 on (the short version of the michigan alcohol screening test \[smast\]48) given during the screening interview * positive family history of alcohol use disorder * weight ≥ 230 lbs (to prevent excessive volume of beverage) * current use of medications that are contraindicated for alcohol * a health condition that contraindicates alcohol (e.g. peptic ulcer disease) * a health condition that affects ability to walk * if female, pregnant or nursing * use of recreational drugs (e.g., marijuana, opioids, stimulants, benzodiazepines) within the last week (self-report plus urine screening cup) * persons who report alcohol-induced flushing, an untoward reaction that is often accompanied by headache, nausea and other symptoms
early-onset and late-onset sporadic alzheimer's disease (ad)

Conditions: Alzheimer's Disease

Summary: alzheimer's disease (ad) is usually associated with aging, age being the principal identified risk factor. however, younger subjects also develop ad and the prevalence of early onset ad is unknown. it is estimated that about 30 000 subjects develop symptoms of ad before the age of 65 in france. there is evidence that early onset ad differs from ad in older patients. in particular, clinical and neuroimaging studies suggest early involvement of neocortical brain regions and their functions in early onset ad, while mediotemporal areas and memory might be more involved in late onset ad. these differences could partly explain the atypical clinical and imaging features of younger patients, the diagnostic difficulties in these patients and the specific problems related to medical care of this age group. the present study uses a multidisciplinary approach with longitudinal followup in order to establish the impact of age on the clinical and neuroimaging picture of sporadic ad in a multicentric setting. another aim of the project is to describe for each age group, and in particular for the younger patient group, the functional impact of disability in everyday life on both, patients and caregivers.


Eligibility criteria:
inclusion criteria: * arm alzheimer disease : first symptoms from 1 to 5 years before the inclusion, clinical dementia rating = 1, efficient contraception for women * arm control : efficient contraception for women exclusion criteria: * important general disease : diabetes, neoplasia, alcoholism * first symptoms less than 1 year or more than 5 years before the inclusion * pregnancy, breast feeding

Keywords: subjects developing symptoms of alzheimer disease
pet-ct imaging features of meibomian glands

Conditions: MGD-Meibomian Gland Dysfunction; Positron-Emission Tomography; Dry Eye

Summary: analysis the results of dry eye analysis results and pet-ct imaging comprehensively

medical records of patients who visited the ophthalmology department between january 2021 and december 2023 and had a pet-ct examination in our hospital within one month were collected. the dry eye analysis results of all patients were collected, and the lacrimal river height, tear film rupture time and meibomian gland grade were counted. the results of pet-ct were collected and the suv values of the tarsal gland were calculated.

Eligibility criteria:
inclusion criteria: * patients who visited the ophthalmology department of zhongnan hospital from january 2021 to december 2023 and had a pet-ct examination in the hospital within one month exclusion criteria: * dry eye analysis was not performed * history of eye surgery or trauma * other systemic diseases affecting the eyes
walnut and immunity study

Conditions: Immune Response; Upper Respiratory Tract Infection

Summary: the main objective of the study is to determine if eating walnuts enhances immune function, in older free-living men and postmenopausal women with overweight.

the main objectives of our proposed study are to determine the effect of walnut consumption on innate, acquired, and gut immunity by assessing whether the ingestion of walnuts enhances immune function, in older free-living men and postmenopausal women with overweight. to accomplish these objectives, a randomized controlled, parallel design study is proposed with two groups consuming their habitual diet, but with one (walnut group) receiving 15% of their total energy as walnuts and the other (control group) abstaining from eating any walnuts and limited amounts of other tree nuts and peanuts (up to \<1 serving/wk).

Eligibility criteria:
inclusion criteria: * older men and post-menopausal women aged 55-75 years * have a bmi of 25-32 * being able to commute to loma linda university. * not taking medication or supplements that affect immunity exclusion criteria: * intolerance or allergy to walnuts * regular intake of walnuts and/or other nuts (\>3 ounces per week). * immune system insufficiency or disease. * using immune boosting supplements. * exposure to antibiotics and corticoids immediately prior to the study. * participants with uncontrolled chronic diseases, and relevant psychiatric illness, including major depression will not be included in study * flu vaccination or covid booster within past 6 months

Keywords: walnuts immunity inflammation
post marketing surveillance (pms) study to assess safety and efficacy of micardis in patients with essential hypertension

Conditions: Hypertension

Summary: the objective of this pms study was to monitor and assess the safety of micardis tablets in patients with hypertension over a period of 6 years


Eligibility criteria:
inclusion criteria: * male and female patients diagnosed with essential hypertension * patients without prior experience with micardis tablet exclusion criteria: * known hypersensitivity to micardis tablet * pregnancy or breastfeeding * biliary atresia * severe hepatic failure patients * severe renal failure patients
prognostic value of circulating tumoral dna after the first 6 months of treatment in patients with waldenström macroglobulinemia

Conditions: Waldenstrom's Disease; Waldenstrom Macroglobulinemia

Summary: waldenström macroglobulinemia (wm) is defined by a bone marrow lymphoplasmacytic infiltration and the presence of a monoclonal immunoglobulin m (igm) in blood. this chronic lymphoproliferative disorder requires treatment only in case of symptoms, according to accurate criteria described during the second workshop on wm i.e. in case of cytopenia, bulky organomegaly, immunological or physicochemical consequences of the presence of igm in circulating blood. a myd88 mutation, typically a myd88(l265p), is found in 90% of wm patients. other gene abnormalities have been observed, the most frequent is a mutation in the cxcr4 gene. overall, gene mutations in wm involve only a limited number of signalling pathways, yielding the activation of nfkb, namely : the tlr and myd88 pathway (with an activation of nfkb and btk in case of myd88(l265p) mutation), the bcr pathway (involving btk and associated with activations of both nfkb, and erk akt pathway) and the cxcr4 pathway (cxcr4 is a receptor of cxcl12, it is also associated with activations of erk/mapk and pi3k). abnormalities of some of genes, such as tp53, of the expression of the protein cxcl13 and genes involved in the interleukin 6 secretion have been associated with some clinical characteristics. the purpose of this project is to define the prognostic role of the detection of circulating tumoral dna (ctdna) at the end of treatment for the progression/relapse risk within the first 3 years after the first 6 months of treatment.


Eligibility criteria:
inclusion criteria: * patient with wm according to diagnostic criteria * patients with wm followed in one of the centre of north-western region. * patients requiring first-line or subsequent-line therapy * patients agreement for giving informed consent. * social insurance system affiliation exclusion criteria: * patients with another chronic b-cell malignancy * patients with other lymphoplasmacytic proliferations * patients with marginal zone lymphoma. * patients with wm and histologic transformation * absence of informed consent

Keywords: waldenstrom's disease waldenstrom macroglobulinemia
brief trainings to buffer against acute stress effects

Conditions: Stress

Summary: the purpose of this study is to evaluate and compare the effectiveness of several brief trainings based on contemplative practices and positive psychology to buffer against the negative effects that acute stress has on behavior and cognitive abilities. the investigators hypothesize that training will buffer against negative effects of acute stress.

participants will be taught a stress reducing training (breath awareness, loving kindness practice, gratitude exercise) and will practice using this technique for 10-15 minutes. following this, all participants will undergo the cold pressor task (cpt) for up to 3 minutes. before and after these tasks, participant data related to attention, working memory, self regulation, affect, and prosociality will be collected.

Eligibility criteria:
inclusion criteria: * undergraduate psychology recruitment pool exclusion criteria: * non-native english speakers, pregnant women
effects of airway conditioning devices on ventilator associated pneumonia:a randomized clinical trial

Conditions: Acute Lung Injury

Summary: the main hypothesis are: 1. passive and active-passive airway conditioning devices reduce the incidence of ventilator associated pneumonia 2. active-passive airway conditioning devices reduce the incidence of endotracheal tube obstruction 3. nurses' workload is reduced with passive and active-passive airway conditioning devices

for all three lines of the study we record clinical pulmonary infection score and airways care score, sofa (sequential organ failure assessment), sedation strategy, glasgow coma score and clinical data.

Eligibility criteria:
inclusion criteria: * patients mechanically ventilated with pao2/fio2 lower than 300 * age higher than 18 years * invasive mechanical ventilation * endotracheal intubation or tracheostomy for more than 24 hours exclusion criteria: * non invasive ventilation * severe ards (pao2/fio2 lower than 100, or paco2 higher than 60 mmhg) * inefficient cough * head trauma * spinal cervical trauma * chest trauma * pregnancy * expectance of poor survival within 72 hours * congenital airway disease * immunosuppression * supraglottic aspiration devices

Keywords: hot water humidifier, passive heat and moisture exchangers
role of actg2 variants in smooth muscle determination and function in pediatric intestinal pseudo-obstruction.

Conditions: PIPO

Summary: the primary objective of this study is to describe the transcriptional impact of r178, r257, r40 or a136 variants of the actg2 gene on ips differentiation mechanisms up to organoids derived from pipo patient samples versus those derived from control / wt patients (generation of ips from cultured cell lines), at different stages of their experimental ex vivo development.

recruited patients will be sampled during a consultation: a blood sample and a biopsy will be taken directly from the patient. once these samples have been taken, they will be cultured to be reprogrammed into ips cells, then grown and differentiated into intestinal organoids. various experiments will be carried out (as described in the outcomes) to identify at molecular, cellular and tissue level the mechanisms altered in patients with an r178, r257, r40 or a136 variant, assessing their consequence(s) on the development and functionality of the digestive mesenchyme.

Eligibility criteria:
inclusion criteria: pipo population: 1. minor or adult patient ≥ 4 years of age 2. patient with pipo before age 18 3. male or female 4. patient with pipo meeting at least 2 of the espghan criteria (thapar et al 2018) and carrying the r178, r257, r40 or a136 mutation of the actg2 gene. 5. patient whose assent has been obtained and whose legal guardians have given their written informed consent 6. patient affiliated to the french social security system or benefiting from an equivalent plan wt population: - ips cell lines ms573 or wt8288 or 202ct or sd378m, from the nantes university hospital biological collection and generated from samples from control patients without poic who have consented to donate their samples. exclusion criteria: pipo population : 1. patients with a history of radiotherapy treatment 2. patient with lymphocyte lineage damage

Keywords: pipo cipo actg2 pseudo-obstruction organoid ips pediatric intestinal pseudo-obstruction chronic intestinal pseudo-obstruction
local injection of steroid vs.glucose 5% in carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: to assess pain relief and quality of life among patients with carpal tunnel syndrome after local steroid vs. glucose 5% injection.

carpal tunnel syndrome (cts) is the most prevalent type of peripheral nerve entrapment involving compression of the median nerve in the carpal tunnel. 1 this condition is more common in females than in males. cts may be unilateral or bilateral. it is a significant cause of morbidity and poor quality of life in those patients. there is deterioration in functional outcomes and maybe psychologically as well. the severity of cts varied from mild to moderate to severe. its signs and symptoms include numbness along with the median nerve distribution of the hand, pain, atrophy of muscles, handgrip weakness, etc. mild or moderate cases are usually seeking conservative treatment like electrotherapeutic modalities, manual therapy interventions, oral supplements and medications, and wrist immobilizations such as splints. severe cases are likely to go toward surgery. but most patients with cts are reluctant to take the surgical choice, mainly because of financial issues and secondary complications. therefore, the evaluation of the effectiveness of the non-surgical (conservative) therapies should be a major concern, as they are cost-effective and lacks secondary complications. much research has been conducted to see the efficacy of various conservative therapies. -study method: we are going to carry out a double-blinded randomized, case-controlled study on 52 patients who are randomly chosen and categorized them into 2 groups, 26 patients each. we planned to inject steroid( 4 mg of dexamethasone acetate combined with 1% lidocaine into the carpal tunnels) directly into the carpal tunnel in (group 1) and to inject 10 ml glucose 5% into the carpal tunnel for the other group (group 2).. all injections will be under sonographic guidance. neurophysiology, u/s, pain scales, and quality of life scales studies will be performed for these two groups before treatment and after 12 weeks of injection. the patients will be followed up for 3 months.

Eligibility criteria:
inclusion criteria: 1. female or male patient \> 18y 2. mild to moderate cases of carpal tunnel syndrome according to bland's neurophysiological grading scale for patients with cts 3. clear consent to participate in the study exclusion criteria: 1. age younger than 18y. 2. severe cases of cts. 3. systemic diseases cause cts .

Keywords: local injection pain relief steroid glucose 5%
comparison of different surgical treatments for different scales of cubital tunnel syndrome

Conditions: Cubital Tunnel Syndrome

Summary: the purpose of this study is to determine which is the best surgery to treat different severity scales of cubital tunnel syndrome.

the purpose of this study is to determine which one of the simple decompression,anterior subcutaneous and intramuscular transposition of the ulnar nerve has the best outcomes for moderate and severe cubital tunnel syndrome.

Eligibility criteria:
inclusion criteria: * patients with confirmed cubital tunnel syndrome * moderate and severe cubital tunnel syndrome. exclusion criteria: * significant cervical spine and shoulder disease * deformity or distortion of the cubital tunnel due to previous trauma to elbow * recurrent cubital tunnel syndrome after previous surgery * mild cubital tunnel syndrome.

Keywords: cubital tunnel syndrome simple decompression anterior subcutaneous transposition of ulnar nerve anterior intramuscular transposition of ulnar nerve severity scale
study of the effect of hydrocortisone administered for the prevention of pulmonary bronchodysplasia (premiloc trial) on the determinants of systemic blood pressure in children (premilocap)

Conditions: Infant, Premature, Diseases

Summary: the risk of arterial hypertension (hta) is increased in very premature infants and hydrocortisone administered in the neonatal period could modify this risk. the main objective is to assess whether the administration of hydrocortisone in the perinatal period in children born prematurely is associated with an increase in pulse wave velocity (pwv) by comparing the future of children included in the premiloc trial (hydrocortisone versus placebo) at the age of 7-13 years. the primary endpoint will be the carotid-femoral pulse wave velocity in m/s.

descriptive cross-sectional study of the subjects included in the double-blind, monocentric randomized controlled trial (children included and followed up at the robert debré hospital in the premiloc trial): follow-up of these children approximately 10 years later on vascular parameters.

Eligibility criteria:
inclusion criteria: * child included in the premiloc trial on the robert debré site * age from 7 to 13 years old (eve of 14 years old) * consent of the holders of parental authority and agreement of the child exclusion criteria: * absence of affiliation to a social security scheme * patient under state medical aid
impact of the information follow-up given to patients on their disease understanding and therapeutic adherence in patients under direct oral anticoagulants and with atrial fibrillation in a cardiology department

Conditions: Atrial Fibrillation

Summary: the primary objective of this study is to measure in patients addressed for atrial fibrillation (af) in the cardiology-electrophysiology and cardiac stimulation department of bordeaux hospital, the impact of a specialized nurse consultation on their adherence level to direct oral anticoagulants treatments.

the number of persons that should take an anticoagulant treatment in france is evaluated at 3 billion and at least half of them for an atrial fibrillation disease. one of the main issues of their prescription is stoke prevention. with the coming of direct oral anticoagulants, which does not require repeating controls like it is the case for anti-vitamin k treatments, the patient's involvement is a guarantee of therapeutic adherence and good use. nevertheless a good adherence level is seldom reached. this highlights the importance of individualized information which must be followed for purposes of accuracy and deepening. thus as part of investigator's activity department that treats about 1000 patients per year for an atrial fibrillation, the information, use and therapeutic adherence are a priority in the care pathway of patients under direct oral anticoagulants. the investigators propose to measure the contribution of a specialized nurse consultation in contact with a multidisciplinary team on therapeutic adherence. the investigators hypothesis that an individualized and reassessed information would allowed a better understanding by the patients of their pathology and care and thus a better therapeutic adherence. a control group will present the same care pathway than all the patients of the service suffering from atrial fibrillation without specialized nurse consultation. the second group will benefit of a specialized nurse consultation throughout of which an individualized information will be delivered. this information will be reevaluated during the usual patient follow-up. all the patients will be followed at 3 months, 6 months and 1 year as part of the usual care of the service.

Eligibility criteria:
inclusion criteria: * patient hospitalized in the cardiology-electrophysiology and cardiac stimulation department for an af, * patient requiring direct oral anticoagulant treatment, * age ≥ 18 years of both genders, * written consent, * patient affiliated or beneficiary of a social insurance, * french language. exclusion criteria: * patient unable to give his written consent or with cognitive disorders, * patient depending of a third person, * patient unable to be followed in the service, * patient in exclusion period for another protocol, * subject deprived of liberty by judicial or administrative decision, * protected adults, * non-inclusion criteria specific to direct oral anticoagulants (valvular af, severe renal impairment).

Keywords: stroke anti-vitamin k direct anti-coagulant nurse