Kornimate/medical-research-clean huggingface dataset:
postoperative atrial fibrillation and long-term survival

Conditions: Death; Stroke; Myocardial Infarction

Summary: the aim of the investigators trial was to evaluate association between new onset postoperative atrial fibrillation (poaf) and late cardiovascular morbidity and mortality.

the material of this retrospective study consist patients without preoperative history of atrial fibrillation, participated in three different randomized controlled trials previously . a total of 519 consecutive patients underwent coronary artery bypass surgery, aortic valve replacement or combined aortic valve with coronary bypass surgery in kuopio university hospital from 2004 to 2008. patients with previous episodes of atrial fibrillation (af) or flutter and also patients with mitral valve surgery were excluded. all patients had continuous postoperative ecg monitoring for at least 48 hours. af episodes lasting longer than 5 minutes were registered. thereafter 12 lead ecg was recorded daily and in case of symptoms of rhythm disturbances. medical records were reviewed during 2012 using standardized data collection protocol. statistics finland database was used for mortality data.

Eligibility criteria:
inclusion criteria: * previously cardiac operation, cabg or avr exclusion criteria: * previous atrial fibrillation

Keywords: atrial fibrillation cabg stroke
computer assisted orthognathic surgery. facial asymmetry

Conditions: Facial Asymmetry

Summary: the specific aims of the study were to measure and compare the rates of alignment and cant reduction of the dental and facial midlines among the two groups.

the purpose of this randomized, controlled, clinical study, was to evaluate the most accurate procedure for orthognathic correction of facial asymmetry. the investigators compared two different methods of surgical planning: classical (esthetic analysis of the face, cephalometric study of the skull in lateral and posteroanterior cephalograms, analysis and surgical simulation of plaster casts mounted in semi-individual articulators, development of a surgical acrylic resin intermediate splint) and digital planning (cone-beam computed tomography, data acquisition, software-assisted virtual surgery -maxilim; medicim, mechelen, belgium- and cad/cam processing of the surgical intermediate splint).

Eligibility criteria:
inclusion criteria: * facial asymmetry or mandibular deviation (cant of the occlusal plane \> 3° and/or midline discrepancies \> 2.5 mm) * presence of all central incisors, * pre- and postoperative radiographs and plaster casts (group 1) * cranial cbct images (group 2) * pre- and postoperative digital photographs. exclusion criteria: * previous trauma involving the hard or soft facial tissues * functional deviation of the mandible * incomplete records (cbct, radiographs, casts or digital photographs).

Keywords: computer-assisted orthognathic surgery; facial asymmetry
b2 adrenergic receptor gene polymorphism in bronchial asthma

Conditions: Gene Abnormality; Asthma

Summary: the b2-adrenoceptor (b2ar) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection. the b2-adrenoceptor (b2ar) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection, enhanced mucociliary clearance. the b2ar gene is located on chromosome 5q31-q32, a region that is genetically linked to asthma and related phenotypes. there are three best known polymorphisms in the coding region of the b2ar gene that can modulate the function of the receptor.

asthma is a complex disease and has a strong genetic component in its pathogenesis. so far, considerable efforts have been made to evaluate the association between genetic variants and asthma risk, and numerous genes have been identified as asthma reporting items susceptible genes. the b2-adrenoceptor (b2ar) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection. the b2-adrenoceptor (b2ar) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection, enhanced mucociliary clearance. the b2ar gene is located on chromosome 5q31-q32, a region that is genetically linked to asthma and related phenotypes. there are three best known polymorphisms in the coding region of the b2ar gene that can modulate the function of the receptor.

Eligibility criteria:
inclusion criteria: * patients diagnosed as asthma according to gina guideline 2016. * allergic asthma exclusion criteria: * pneumonia * chronic cardiac, hepatic and renal diseases * pregnancy and lactation * malignancy

Keywords: asthma b2 adrenergic receptors polymorphism
"info-af" information preferences in patients with atrial fibrillation/flutter and the association with clinical symptoms

Conditions: Atrial Fibrillation

Summary: the aim of this project is to identify a variable that discerns patients who are interested in their disease (atrial fibrillation/atrial flutter) from patients who show no interest and furthermore test this theory in a questionnaire survey. this should help distinguish between patients who are interested in shared decision making and patients who are not (further projects planned).


Eligibility criteria:
inclusion criteria: * current atrial fibrillation/flutter * \>18 years of age * sufficient knowledge of the german language to fill out the questionnaire exclusion criteria: * \< 18 years of age * insufficient knowledge of the german language to fill out the questionnaire * hemodynamic instability
effect of rebound exercise in individuals with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: the purpose of this study was to investigate the effect of rebound exercise (mini trampoline jumping) on metabolic outcomes and quality of life in patients with type 2 diabetes.

the exercise involved jumping on the mini trampoline with feet slightly apart. participants stood on the mid portion of the trampoline bed and made repeated up-and-down bouncy movements. each foot strike equals one step or bounce. with each landing, the mat of the trampoline underwent deformation and the springs released the energy stored in them such that the participant was made to bounce off the mat. exercise was administered for between 10 - 15 minutes after which a 5-minute period of rest was allowed. a heart rate monitor was used to guide the intensity of the exercise in the moderate range. each participant accumulated between 20 and 30 minutes of rebound exercise (bouncing on a mini trampoline) per session, administered three times per week for 12 weeks. all data were captured at baseline and at the end of the 12-week intervention period.

Eligibility criteria:
inclusion criteria: * 30- to 60-year-old male and female individuals; * a diagnosis of type 2 diabetes ≤ 5 years; * attendance at the diabetes outpatient clinics of aminu kano teaching hospital and murtala muhammad specialist hospital in kano, northwestern nigeria; * self-ambulatory; * an inactive lifestyle over the last year. exclusion criteria: * a diagnosis of type 2 diabetes for more than 5 years; * hypertension (systolic and diastolic blood pressure more than 140 and 90 mmhg, respectively) or treatment for hypertension; * use of insulin therapy * lower limb weakness and/or deformities with loss of protective sensation in the feet; * back, shoulder or knee problems and/or joint instability; * history of coronary artery disease, retinopathy and nephropathy; * myocardial infarction, cardiac or abdominal surgery within the previous 6 months; * history of fractures of the spine, hip, knee and/or ankle joints.
adenomyosis in fertile women in musa criteria

Conditions: Adenomyosis

Summary: 1. to estimate the prevalence of adenomyosis in fertile women aged 18-30 years using the revised musa ultrasound criteria. 2. to evaluate clinical risk factors that are associated with adenomyosis diagnosis in this population

adenomyosis is a benign condition characterized by the presence endometrial glands and stroma within the myometrium. its prevalence varies from 5-70%. the definitive diagnosis of adenomyosis is based mainly on histological assessment of hysterectomy specimens. this led to a concept that adenomyosis affects only parous women between 35-50 years who complain of dysmenorrhea and heavy menstrual bleeding. magnetic resonance imaging (mri) can detect adenomyosis with a sensitivity of 80%. transvaginal ultrasound using the revised morphological uterus sonographic assessment (musa) criteria can detect adenomyosis non-invasively at a lower cost. such advancements in imaging techniques allow studying the prevalence of the disease in wider range of population including young women.

Eligibility criteria:
inclusion criteria: * women with regular menstrual cycle attending outpatient clinic for contraception counseling * age 18 -30 years old exclusion criteria: * women on hormonal contraception * infertile women * associated pathologies like endometriosis, uterine fibroids. and ovarian cysts
functional correlates of bipolar disorders and effects of the psychoeducation. an fmri study

Conditions: Conditions Influencing Health Status; Bipolar Disorders

Summary: this research project follows two main objectives: 1) assess anatomical and functional cerebral abnormalities in bipolar disorder. 2) evaluate anatomical and functional changes after the application of a psychoeducational program in these patients. specifically, this project aims to assess neurophysiological (fmri - activation and functional connectivity) and neuroanatomical (morphometry and diffusion tensor imaging) specificities related to bipolar disorders and the therapeutic response to the psychoeducation. the results of this thesis project would also contribute to the validation of a pathophysiological model of the bipolar disorder.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of bipolar disorders * euthymic (montgomery and asberg depression rating scale \< 10, young mania rating scale \< 10) exclusion criteria: * other concomitant psychiatric disorders

Keywords: bipolar disorders euthymic psychotherapy functional magnetic resonance imaging
bioequivalence study comparing linezolid 600 mg oral suspension with 600 mg tablet in chinese healthy male subjects

Conditions: Healthy Volunteers

Summary: the purpose of this study is to estimate the bioequivalence comparing linezolid 600 mg oral suspension with 600 mg tablet in chinese healthy male subjects. this study data will be used to support linezolid os nda in china.

to support linezolid nda in china.

Eligibility criteria:
inclusion criteria: * healthy volunteers. * 18-40 years old, male. * bmi 19-24kg/m2. exclusion criteria: * alcohol, drug, smoke user. * sensitive to oxazolidinones antibiotics class drug or heparin. * severe medical or psychiatric condition or laboratory abnormality. * blood donation. * 12-ecg abnormal. * treatment with study drug; clinically significant.

Keywords: bio-equivalence linezolid os linezolid tablet
glofitamab in real life

Conditions: Large B-cell Lymphoma

Summary: to date, more than 300 patients have been treated with glofitamab in the expanded access programme (eap) in france. in this study, it is proposed to perform a retrospective analysis of some of these patients. the aim is to describe the efficacy and safety of glofitamab in the largest reported real-world cohort, with an expected median follow-up of more than 9 months. particular focus will be given to the relapsed or refractory chimeric antigen receptors-t (car-t) population to confirm the response rates (crr: 35-39%) of glofitamab in this population and to assess the optimal timing of therapy initiation \[8, 15\].


Eligibility criteria:
inclusion criteria: * patient enrolled in the french glofitamab eap for r/r dlbcl before 2024 november 1st, 2024 * patient who received at least obinutuzumab pretreatment and one infusion of glofitamab * adult patient * patient who is informed of the study and who did not oppose to their data collection exclusion criteria: * none

Keywords: car-t glofitamab
transition to ferric citrate among hemodialysis and peritoneal dialysis patients

Conditions: Hyperphosphatemia

Summary: transition to ferric citrate among hemodialysis and peritoneal dialysis patients: a phase 4 "real world" experience study from kaiser permanente southern california

protocol summary title: transition to ferric citrate among hemodialysis and peritoneal dialysis patients: a phase 4 "real world" experience study from kaiser permanente southern california short title: fecitrate protocol number: kp fecitrate study phase: 4 study site(s): los angeles kaiser sunset medical center number of subjects: 55 study arms: 1 indication: hyperphosphatemia in end stage renal disease primary purpose: to evaluate the efficacy of ferric citrate for control of serum phosphorus levels and maintenance of adequate iron stores among dialysis-dependent patients before and after conversion from traditional phosphate binders in a "real world" environment overview of study design: prospective non-randomized cohort study of 6-9 months duration (active study period 6 months). investigational product administration: one to two tablets of ferric citrate phosphorus binder administered by mouth before every meal to prevent dietary phosphorus absorption. study endpoint: mean serum phosphorus levels and rate of successful phosphorus control (\<5.5mg/dl) 6 months before and after treatment with ferric citrate statistical methods: not powered to detect statistical significance

Eligibility criteria:
inclusion criteria: * currently using 3 to 18 pills per day of calcium acetate, sevelamer, lanthanum, or calcium carbonate * mean serum phosphorus 4.0-\<8.0 mg/dl for 6 months prior to enrollment * no allergy to iron * mean corrected serum calcium \> 8.0 mg/dl for 6 months prior to enrollment * mean pth \< 1000 pg/ml for 6 months prior to enrollment * mean ferritin \< 1500 ng/ml and mean iron sat \< 50% for 6 months prior to enrollment exclusion criteria: * history of gastrointestinal bleeding within past 6 months * history of hospitalization for gastroparesis, bowel obstruction, or abdominal surgery within past 6 months * acute kidney injury equal to or less than 3 months before the initial screening date * active malignancy * functioning renal transplant * patients with iron overload syndrome (e.g., hemochromatosis) * history autoimmune disease, hemoglobinopathy, hemochromatosis, sickle cell disease * active or past history of calciphylaxis
effect of l-thyroxine on lipid profiles and atherosclerosis in subclinical hypothyroidism

Conditions: Hypothyroidism; Thyroid Diseases; Endocrine System Diseases

Summary: subclinical hypothyroidism (sch) is a common condition affecting 3-10% of the general population, especially in women older than 50 years old. it is controversial whether sch can lead to increased risks of cardiovascular (cv) disease and whether treatment with l-thyroxine reverses these risks. the present study was designed to evaluate the effect of l-thyroxine treatment in sch on lipid profile, atherosclerosis, endothelial function, serum inflammatory factors and adipocytokines.


Eligibility criteria:
inclusion criteria: * male and female aged of 18 to 60 years old; * diagnosis was subclinical hypothyroidism(elevated serum thyroid-stimulating hormone levels with normal serum free t4 levels measured at least two times with a three-month interval); * untreated. exclusion criteria: * pregnancy or lactation women; * presence of pituitary/hypothalamic disorders, diabetes mellitus or other endocrinal and metabolic disorders; * presence of psychological or physical disabilities,acute infection, cerebrovascular or cardiovascular disease, chronic respiratory disease and other illnesses known to alter lipid metabolism; * taking lipid-lowering agents and other drugs that known to influence thyroid function, blood pressure, heart function or bile acids; * obviously poor compliance.

Keywords: subclinical hypothyroidism l-thyroxine lipid endothelial function inflammatory factor adipocytokine
diabetes type 2 in the eastern region of morocco

Conditions: Quality of Life; Diabetes Mellitus, Type 2; Adherence, Medication; Diet Habit

Summary: this south initiative is the first step towards a long-term general objective that aims to improve the manage-ment of type 2 diabetes (t2d) and concurrently create jobs for health professionals in eastern morocco by developing a multidisciplinary approach in the management of t2d, based upon international guidelines but adapted to the regional socio-economic and cultural context, and with a focus on empowerment of muslim women. the intermediate results of this si project proposal are: 1) facilitators and perceived barriers in female patients with t2d towards change to a healthier lifestyle are known. 2) characteristics of patients with t2d in the region of oujda (prevalence, lifestyle, age, gender,...) are analysed. 3) master and bachelor students have gained experience by participating to relevant research. 4) all involved stakeholders shared existing and newly ac-quired knowledge and expertise. 5) facilitators and perceived barriers in health professionals of different disciplines to work together in the management of t2d are known.

the ultimate objective is to help improve the quality of life and well-being of people living with diabetes in the oujda region. this 2-year project will tackle the prerequisites and optimise the conditions needed to start a larger (team) project. afterwards, in the larger long-term (team) project we will study the cost-of illness of t2d in oujda, the effect of a cultural-sensitive multidisciplinary intervention for t2d and the cost-effectiveness of such an intervention. in doing so we hope to provide not only arguments from a health perspective for such an approach, but also from a quality of life and economic point of view. this is needed to persuade political decision makers to invest in sustainable innovation in health care. this could open the job market for many young physiotherapists, nutritionists and occupational therapists in health centres and primary care. the specific objectives of this 2-year si project are 1) to know the characteristics of t2d patients in oujda and their perceived barriers and benefits towards participation in a lifestyle program and 2) to improve communication and cooperation between health professionals of different disciplines treating patients with t2d. the intermediate results of this 2-year project are well defined and feasible (annex 4). the two years of the si project will be devoted to gathering information from diabetic women as well as from health profes-sionals, to creating a platform and to strengthening research capacities. the changes needed to reach the si project outputs are related to 1) knowledge/capacity and 2) attitude/behaviour.

Eligibility criteria:
inclusion criteria: * women * visiting the 35 local health centres and the crd in oujda * adult * moroccan exclusion criteria: * male * no informed consent

Keywords: diabetes mellitus type 2 quality of life interdisciplinary care
study of usefulness of fluorescence in thiroid surgery

Conditions: Thyroid Surgery

Summary: in thyroid surgery, the identification and preservation of the parathyroid glands and their vascularization is essential to avoid postoperative hypoparathyroidism. in this sense, fluorescence technology with autofluorescence (af) can help us avoid this post-surgical complication. this study aims to determine the advantages offered by fluorescence in thyroid surgery, taking into account various clinical variables. for this, a randomized study is proposed in patients undergoing thyroid surgery with and without cervical fluorescence.


Eligibility criteria:
inclusion criteria: * total thyroidectomy with/without lymph node dissection * signature of informed consent exclusion criteria: * patients under 18 years of age * hemithyroidectomy * reintervention of thyroid surgery
the effect of yogurt enriched with flaxseed on cardiovascular risk factors in type 2 diabetic patients

Conditions: Diabetes Mellitus

Summary: the investigators aimed to add flaxseed with high content of n-3 polyunsaturated fatty acids to low fat yogurt to obtain beneficial without adverse effects of it. in this parallel randomized controlled trial the investigators recruited 70 diabetic patients and randomly allocated to control and treatment groups. participants in treatment group consumed 30 gr flaxseed in 200 gr low fat yogurt, while controls consumed 200 gr just low fat yogurt daily. lipid profile, fasting blood sugar, glycosylated hemoglobin, systolic and diastolic blood pressure, weight, waist circumference and body mass index were measured at the first and end of the trial.

nutritionists have concern about consumption of full fat dairy in diabetic patients due to their content of saturated fatty acids. the investigators aimed to add flaxseed with high content of n-3 polyunsaturated fatty acids to low fat yogurt to obtain beneficial without adverse effects of it. in this parallel randomized controlled trial the investigators recruited 70 diabetic patients and randomly allocated to control and treatment groups. participants in treatment group consumed 30 gr flaxseed in 200 gr low fat yogurt, while controls consumed 200 gr just low fat yogurt daily. lipid profile, fasting blood sugar, glycosylated hemoglobin, systolic and diastolic blood pressure, weight, waist circumference and body mass index were measured at the first and end of the trial.

Eligibility criteria:
inclusion criteria: * bmi between 20 and 35 kg/m2 - * treated with oral hypoglycemic agents (metformin or glibenclamide) * no use of insulin * fasting blood glucose≥ 126 (but less than 400 mg/dl)or 2 hours blood sugar ≤ 200 mg/dl * no pregnancy and lactation * blood lipids and blood pressure-lowering agents must remained unalteredwithin the last 3 months. exclusion criteria: * participants were excluded if they smoked, used alcohol, took dietary supplements containing omega 3, phytoestrogens, antioxidants and fiber regularly, had been diagnosed with gi disease or renal, liver, cancer , inflammatory disease, had food allergies or intolerances

Keywords: diabetic patients flaxseed lipid profile cardiovascular risc factors
adjunct inversion for lower pole stone

Conditions: Kidney Stone

Summary: this is a randomized controlled trial comparing extracorporeal shockwave lithotripsy (eswl) with and without simultaneous adjunct controlled inversion therapy in the treatment of lower pole caliceal stone.


Eligibility criteria:
inclusion criteria: 1. solitary lower pole caliceal stone which is \> 5 mm and \< 20mm 2. not contraindicated for intravenous urogram (ivu) and subsequent x-rays 3. patient able to comply strictly with visits/medications 4. patient willing and agrees to enter study exclusion criteria: 1. impaired function of the affected kidney 2. gross hydronephrosis of the affected kidney 3. associated distal obstruction 4. multiple stones 5. stone more than 2 cm in size 6. diverticular stone 7. patients who are contraindicated for extracorporeal shockwave lithotripsy e.g.: pregnancy 8. patients who are unable to tolerate the procedure 9. significant cardiac condition that does not allow the administration of force hydration or inversion. 10. uncontrolled hypertension
efficacy and safety study of d9421-c 9 mg and 15 mg versus placebo in japanese patients with active crohn's disease

Conditions: Crohn's Disease

Summary: the purpose of this study is to determine whether treatment with d9421-c for 8 weeks in japanese patients with mild to moderate active crohn's disease will improve their symptoms of crohn's disease and quality of life.


Eligibility criteria:
inclusion criteria: * female or male aged ≥ 18 and ≤ 65 years * diagnosis of crohn's disease exclusion criteria: * having ileostomy or pouch and/or colostomy * having previous gastric surgery * having a known or suspected systemic infection

Keywords: gastrointestinal gi crohn's disease japan japanese