Kornimate/medical-research-clean huggingface dataset:
therapeutic effects of topical herbal medicine -rhubarb ointment on rosacea

Conditions: Rosacea; Chinese Herbal Medicine

Summary: the aim of this study is to investigate the effects of topical herbal medicine in the patients with rosacea.

rosacea is a chronic inflammatory disorder which affects the cheek, nose, chin, forehead and eyes. it is typically characterized by cutaneous signs such as flushing, erythema, telangiectasia, papules, and pustules in the face. the pathogenic mechanism of rosacea is unknown, and there is no cure for rosacea. the therapeutic approaches include oral medicine, topical medicine and surgical interventions depending on the different subtypes of rosacea. the recent study demonstrates that combination therapy may be more effectively improved the symptoms of rosacea. dian dao san is a topical herbal compound for reducing the features as flushing, erythema, papules, and pustules for years. the investigators hypothesize that dian dao san can be more beneficial in treating the patients with rosacea and improving the quality of life.

Eligibility criteria:
inclusion criteria: * willing to sign inform consent * aged above 20 years old with rosacea * no treatment for rosacea within 2 weeks exclusion criteria: * with malignant lesion in the rosacea lesion * rosacea lesion with high risk of infection * allergy to chinese herbal medicine patch or ointment * pregnancy
evaluating placental thickness and thickness of uterine muscle at placenta attachment in prediction of postpartum blood loss in placenta accreta

Conditions: Post Partum Hemorrhage

Summary: aim of the work is to determine the significance of the placental thickness and the thickness of the uterine muscle layer at placental attachment in the prediction of postpartum hemorrhage in cases of placenta previa accreta and to evaluate both of them as as parameters for identifying high-risk patients.


Eligibility criteria:
inclusion criteria: * term pregnancy (37 wk gastation and more ) * single viable fetus exclusion criteria: * severe hematological disorders that could cause abnormal coagulation * previous history of pph * twins * preterm labour * iufd

Keywords: post partum hemorrhage placental thickness cesarean section vaginal delivery
investigation of the acute cognitive, mood and autonomic effects of hops in healthy participants

Conditions: Mood Modulation; Modulation of Cognition

Summary: hops have been used for many years for their supposed sedative and anxiety reducing properties and can be found in many natural remedies for stress, anxiety and sleeping that are already available to buy. however, human trials investigating the effects of hops have so far been limited to the effects of the combination of hops and valerian in relation to sleep. such studies have identified that a valerian-hops mixture can result in improved sleep but valerian alone has no effect. the current study aims to investigate the effect of hops alone in healthy human participants aged 18-35 years.


Eligibility criteria:
inclusion criteria: * male/female, * healthy * age 18-35 years old * non smoker * proficient in english * not taking any herbal or prescription medications * not pregnant seeking to become pregnant or breastfeeding exclusion criteria: * allergy or hypersensitivity to any of the ingredients contained in the investigational product or any other foodstuff. * vegetarian (as the capsules contain gelatine). * have a history of neurological, vascular or psychiatric illness (including depressive illness and anxiety). * have a current/ history of drug or alcohol abuse. * currently take medication (excluding the contraceptive pill). * high blood pressure (\>140/90) * bmi outside of the range 18- 34.9

Keywords: hops mood cognitive function bioavailability satiety blood pressure heart rate
bilateral peribulbar block for cataract surgery

Conditions: Safety; Efficacy; Bilateral; Peribulbar Block; Cataract Surgery

Summary: this study aims to evaluate the safety and efficacy of bilateral peribulbar block for cataract surgery.

cataract surgery is one of the most commonly performed procedures worldwide, with local anesthesia being the preferred method due to its safety, efficacy, and cost-effectiveness. peribulbar anaesthesia has gained popularity due to its relative efficacy in generating ocular akinesia and anaesthesia with a reduced risk of consequences such as optic nerve damage and globe perforation.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * both sexes. * american society of anesthesiology (asa) physical status i-iii. * patients undergoing cataract surgery exclusion criteria: * infection at the site of the surgery. * allergy to any of the used drugs. * coagulopathy. * posterior staphyloma. * bronchial asthma. * bradyarrhythmia. * pre-existing ocular muscle paresis. * neurological deficit. * co-existing inflammatory conditions of eye. * complicated cataracts. * previously operated eyes.
clinical evaluation of osna breast cancer system to test sentinel lymph nodes from patients with breast cancer

Conditions: Breast Neoplasms; Breast Diseases

Summary: the study will determine the sensitivity, specificity, negative predictive value and positive predictive value of the osna breast cancer system by comparing its performance to permanent section hematoxylin and eosin (h\&e) and ihc staining.


Eligibility criteria:
inclusion criteria: * male or female patients, over the age of 18, diagnosed pre-surgically with t1 or t2 breast cancer and scheduled for surgery including sentinel node dissection. * patients who have read and understand the informed consent form and are capable and willing to provide written informed consent. exclusion criteria: * patients diagnosed pre-surgically with large or locally advanced (t3 and t4) breast cancers. * patients diagnosed with inflammatory breast cancer. * patients diagnosed with ductal carcinoma in situ (dcis) when breast conserving is to be done. * patients who are pregnant, as confirmed by a patient/treating physician interview. * patients with suspicious palpable axillary lymph nodes. * patients currently being treated for or previously diagnosed with, another type of carcinoma. * patients who have undergone prior non-oncologic breast surgery or axillary surgery. * patients who have received pre-operative systemic therapy. * patients who are incapable of providing written informed consent. * patients who have been judged to be inappropriate by a medical care provider (i.e. surgeon, oncologist, pathologists, etc.).

Keywords: metastasis molecular pathology
study of high dose vitamin c on outcome in cardiac surgery patients

Conditions: Reperfusion Injury

Summary: it has been shown that the stress that occurs during cardiac surgery leads to early decrease of many of the body's resources such as vitamin c (ascorbic acid) which may contribute to complications after surgery. this study will investigate the effects of high doses of intravenous (iv) vitamin c on the outcome and complications after cardiac surgery.

patients undergoing cardiac surgery are at significant risk for multiple major complications beyond those associated with other major operations. most patients survive these events, but up to 10% develop injury to organ systems including the kidneys, lungs, pancreas, brain, etc. it has been shown that the stress that occurs during this critical period (cardiac surgery) leads to early decrease of many of the body's resources such as vitamin c (ascorbic acid) which seem to contribute to these complications. this study will investigate the effects of high doses of intravenous (iv) vitamin c administered before, during and after the cardiac surgery.

Eligibility criteria:
inclusion criteria: * adult patients 18 years or older undergoing elective or urgent (prior to hospital discharge) cardiac surgery. exclusion criteria: * history of renal insufficiency, nephrolithiasis, g6pd (glucose-6-phosphate dehydrogenase deficiency) or the chronic use of steroids.

Keywords: free radicals ascorbic acid cardiac surgery prevention of reperfusion injury
the effect of glucagon like peptide (glp)-1 in psoriasis

Conditions: Psoriasis

Summary: the objective of this study is to investigate the effect of the glp-1 analogue victoza® on psoriasis in a double-blinded, randomized placebo-controlled clinical trial.


Eligibility criteria:
inclusion criteria: * caucasians above 18 years of age * plaque psoriasis * pasi score \>10 * no treatment or stable treatment of psoriasis during at least 3 months before inclusion * steady weight through 3 months with a body mass index (bmi) above 27 kg/m2 * normal blood pressure * spiral or hormonal birth control for fertile women during the entire treatment period and at least 3 days after the end of the treatment period (\~5 times the plasma half-life) exclusion criteria: * psoriasis arthritis * fasting plasma glucose \> 7.5 mmol/l or hba1c \> 7.5% * type 1 diabetes * treatment for type 2 diabetes with glp-1-based medicine (ddp-4-inhibitors or glp-1-receptor-agonists) * heart failure, nyha class iii-iv * uraemia, end-stage renal disease, or any other cause of impaired renal function with s-creatinine \>150 µm and/or albuminuria * liver disease (alanine amino transferase (alat) and/or aspartate amino transferase (asat) \>2 x upper normal serum levels) * anaemia * acute or chronic pancreatitis * struma or thyroid cancer * pregnancy or breast feeding * inability to complete the study

Keywords: psoriasis liraglutide morbidity pasi dlqi
performance and safety of a digital tool for unsupervised self-assessment of nmosd

Conditions: Neuromyelitis Optica

Summary: nmosdcopilot is a digital tool developed for the self-assessment of neuromyelitis optica spectrum disorder symptoms that impact patients' functioning and quality of life. it has been co-designed with the help of patient advocacy groups, nmosd patients and medical experts. it includes a smartphone-based application for patients, connected to a web portal developed for healthcare professionals (hcsps). the patient application is composed of vision, walking, cognition, and dexterity e-active tests inspired by clinical standards, as well as e-questionnaires. the hcp web portal is a desktop-based software that allows hcps to access the results generated via the patient application and facilitates remote monitoring of patients' symptoms. the objectives of this study are to validate the accuracy, reliability and reproducibility of the unsupervised at-home self-assessment of symptoms on the patient's smartphone versus the standard in-clinic testing, as well as to evaluate the safety of use of the tool, its usability, and satisfaction towards the patient application among nmosd patients, and the hcp web dashboard among hcps.


Eligibility criteria:
inclusion criteria: * aged over 18 years old * nmosd as defined by the 2015 international consensus diagnostic criteria (aqp4+ only) * with nmosd treatment (treatment must be unchanged since 6 months before enrollment, and 1 month for analgesics, antidepressants, neuroleptics) * edss =\< 7 * with no evidence of relapse in the past 3 months before enrollment * who have read the information sheet and signed the informed consent form * able to use a smartphone * owns a personal smartphone which version is above 13 for ios and 8 for android included * able to read language in which the mobile application is available and able to understand pictograms exclusion criteria: * evidence of neurologic, rheumatologic or psychiatric disorder other than nmosd, including but not limited to major head trauma, seizures or systemic medical diseases that are likely to affect cognitive, upper limb or lower limb functioning * pregnant and nursing women * person under guardianship or curatorship * bedridden patients or patients with a daily activity of less than 2 hours per day * current drugs or/and alcohol abuse that could influence performance on the tests (clinician's judgment) * subject has participated in another clinical study within the previous 30 days of screening or is currently participating in another study that, in the opinion of the investigator, might interfere with the participant's full participation in the study or confound the assessment of the participant or outcome of the study.

Keywords: nmo nmosd neuromyelitis optica neuromyelitis optica spectrum disorder
non-interventional study describing direct costs related to anti-coagulation treatment

Conditions: Atrial Fibrillation

Summary: to describe the direct costs related to warfarin/apixaban treatment

to describe the direct costs related to warfarin/apixaban treatment during the first 6 months of the secondary stroke prevention in nvaf patients.

Eligibility criteria:
inclusion criteria: * diagnosis of non-valvular atrial fibrillation (nvaf); * new initiation of anticoagulation therapy (apixaban or warfarin) due to the ischemic event (stroke/tia) meaning patients previously not anticoagulated due to diagnosis of nvaf; * indication to anticoagulation therapy as a secondary stroke prevention within 7 to 30 days after the stroke/tia event; * apixaban arm: genetically determined higher sensitivity to warfarin; * patients whose status allowed oral treatment with apixaban/warfarin; * age ≥ 18; * access to patient´s records of the first 6 months of the warfarin/apixaban treatment. exclusion criteria: * diagnosis of valvular disease; * treatment with other anticoagulants in previous 6 months due to other the nvaf indication; * treatment or prophylaxis of deep vein thrombosis or pulmonary embolism; * contraindications according smpc of eliquis
early prone position on coronavirus disease 2019 pneumonia

Conditions: Coronavirus Infection; Acute Respiratory Failure

Summary: the purpose of this study to evaluate the effect of early awake pp (prone position)application on oxygenation and intubation requirement in patients with acute respiratory failure due to coronavirus disease 2019 pneumonia.

the first group (early prone position-epp) created for our study was composed of patients who received pp at least 12 hours early (with the first 48 hours) with the oxygen support of the reservoir mask, and the second group (non-epp ) patients who received oxygen with the reservoir mask but could not be applied early pp due to the patient's incompatibility or rejection. conventional oxygen therapy applied to all patients was given with a reservoir mask, aiming at oxygen saturation 93% and above, at a flow rate of 6-15 l / min. despite all the treatments, the patients who have a follow-up with a respiratory acidosis , oxygen saturation value below 93%, applied non invasive mechanical ventilation, in case of insufficient patient intubated and have invasive mechanical ventilation. in patients who had regression of glasgow coma scale during follow-up, orotracheal intubation was performed and invasive mechanical ventilation was performed.

Eligibility criteria:
inclusion criteria: * patients who developed acute respiratory failure due to coronavirus disease 2019 pneumonia * received conventional oxygen therapy with reservoir mask oxygen at the stage of admission to the intensive care unit * older than 18 years old exclusion criteria: * patients with respiratory acidosis, * partial oxygen pressure/fraction of inspired oxygen ratio below 150, * glasgow coma score (gks) below 12 points, * hemodynamic instability, * primary pulmonary pathologies other than pneumonia (lung cancer, cardiopulmonary edema, carcinogen syndrome, etc.) * patients who underwent non-invasive mechanical ventilation(nimv) or intubated from admission to intensive care, * those who underwent self prone position under 12 hours were not included in the study.

Keywords: coronavirus disease 2019 prone position
psma-pet/ct to assess the expression of specific membrane antigen (psma) in patients with progressive triple-negative breast cancer.

Conditions: TNBC - Triple-Negative Breast Cancer

Summary: this is a descriptive, prospective, single centre study. this study will assess psma expression via the uptake of radiolabelled psma-ligand using pet/ct imaging in mtnbc lesions pre-identified on 18f-fdg pet/ct in order to evaluate the feasibility of molecular radionuclide therapy in refractory mtnbc using the lutetium-177 radiolabelled psma.


Eligibility criteria:
inclusion criteria: * written informed consent in accordance with institutional guidelines and obtained prior to any study procedure * women with ≥ 18 years-old * eastern cooperative oncology group performance status of 0 to 2 * confirmed diagnosis of progressive metastatic tnbc and presenting measurable disease on 18f-fdg pet/ct (performed within 2 weeks) or brain mri in case of progressive brain metastases (performed within 4 weeks) prior to psma pet/ct. * radiolabelled psma pet/ct has to be performed before the next treatment line initiation exclusion criteria: * pregnant or lactating patients * other active neoplastic disease * treatment by another molecule that is the object of investigation within 30 days * skin only metastatic disease * patients with a significant medical, neuro-psychiatric, or surgical condition, which, in the investigator's opinion, may interfere with completion of the study
correlation of auscultatory severity of aortic stenosis with trans thoracic echocardiography

Conditions: Aortic Stenosis

Summary: according to the 2006 acc/aha practice guidelines for valvular heart disease, patients with asymptomatic aortic stenosis(as) should have screening transthoracic echocardiograms (tte) performed annually for severe disease, every 1-2 years for moderate disease and every 3-5 years for mild disease. this results in a multitude of screening studies in the investigators patient population. 3m has developed a new stethoscope and phonocardiography software capable of identifying the peak intensity of the as murmur and tracking it as it moves towards the second heart sound potentially indicating increasing severity of disease. currently there exists no data to demonstrate that the aortic stenosis acceleration index (asai) correlates to disease severity or progression of disease. the asai measures the timing of the peak intensity of the systolic murmur and compares it to the total time in systole (s2-x/s2-s1) where s1 is the first heart sound; s2 is the second heart sound and x with the time between s1 and the peak intensity of the murmur. in this study the investigators propose to correlate the asai to standard tte measurements of aortic stenosis severity.


Eligibility criteria:
inclusion criteria: 1. male and female subjects 18 years of age and older. 2. subjects must have asymptomatic aortic stenosis documented by prior echocardiographic examination. 3. subjects must be able to sit for auscultation examination. 4. subject must be able to complete a tte . 5. subjects must voluntarily agree to participate in the study and sign the informed consent and healthcare information authorization forms. exclusion criteria: 1. subjects with significant additional valvular heart disease. 2. subjects with unrecordable heart sounds. 3. subjects with known or who may have been previously diagnosed with congenital heart disease. 4. subjects with atrial fibrillation. 5. subjects with history of cardiac surgery. 6. subjects who have conditions which the researcher feels may limit the recordability of the heart sounds or the accuracy of the echocardiogram.

Keywords: auscultation aortic stenosis computer assisted auscultation aortic stenosis acceleration index
effects of aerobic and diaphragmatic exercises on choir singers

Conditions: Respiratory Muscles; Cardiorespiratory Fitness

Summary: the goal of this randomized-controlled study is to compare the effects of diaphragmatic breathing exercise training provided by a physiotherapist and aerobic exercise training applied in addition to diaphragmatic breathing exercise training provided by a physiotherapist on respiratory functions and voice performance in choir singers. the main questions this study aims to answer are: * is diaphragmatic breathing exercise training provided by a physiotherapist effective in improving the respiratory functions of choir singers? * is diaphragmatic breathing exercise training provided by a physiotherapist effective in improving the vocal performance of choir singers? * does aerobic exercise training applied in addition to diaphragmatic breathing exercise training provided by a physiotherapist have a greater effect on improving the respiratory functions of choir singers compared to diaphragmatic breathing exercise training applied alone? * does aerobic exercise training applied in addition to diaphragmatic breathing exercise training provided by a physiotherapist have a greater effect on improving the vocal performance of choir singers compared to diaphragmatic breathing exercise training applied alone? the research data are going to be collected by sociodemographic information form, international physical activity questionnaire-short form, self-performance evaluation questionnaire, vocal fatigue index, singing voice handicap index, measurement of maximum phonation time, pulmonary function test, maximal inspiratory and expiratory pressure measurement, and 6-minute walk test.

in this study, it will be examined whether aerobic exercise training applied in addition to diaphragmatic breathing exercise training provided by a physiotherapist improves respiratory functions and voice performance in choir singers more, when compared to diaphragmatic breathing exercise training applied alone. the participants will be randomly divided into three groups: diaphragmatic breathing exercise training group, aerobic exercise training group applied in addition to diaphragmatic breathing exercise training, and control group.

Eligibility criteria:
inclusion criteria: * being a chorist in an active choir that rehearses at least once a week for an average of 2 hours * having an inactive or minimally active physical activity level according to the international physical activity questionnaire-short form * being between the ages of 25-60 * being willing to participate in the study exclusion criteria: * having a neurological or orthopedic disease * having a condition related to the cardiopulmonary system that would prevent exercise according to the physical activity readiness questionnaire (par-q)

Keywords: singing respiratory function tests voice diaphragm exercise, aerobic
percutaneous trans-facet spine fixation

Conditions: Degenerative Spine; Degeneration of Lumbar Intervertebral Disc; Degenerative Cervical Disc Disease; Ligamentum Flavum Hypertrophy; Spinal Canal Stenosis; Spine Instability

Summary: percutaneous trans-facet fixation massoud-goel technique and theory for treatment of degenerative spine

massoud-goel' as rationale treatment for treatment spinal degeneration affected spinal segments using trans-articular screws, without physically distracting the facets, or removal of any part of the bone or ligament. following fixing of the segment, all the secondary phenomenon reverse, effectively increasing the canal size and reversing the effects of spinal degeneration and spinal canal stenosis. stabilizes the region and provides an environment for resorption of the herniated disc and ultimate arthrodesis of the spinal segments.

Eligibility criteria:
inclusion criteria: for lumbar sub-axial cervical instability clinical radicular symptoms can indicate the level of spinal instability. the presence of osteophytes. reduction of the intervertebral disc space. disc prolapse. ligamentum flavum buckling. for atlantoaxial instability cervical myelopathy clinical alteration of atlantodental interval on dynamic flexion-extension images. exclusion criteria: 1. cauda equine syndrome 2. progressive motor weakness 3. failed damage control method 4. spondylolisthesis, spondyolysis.

Keywords: percutaneous trans-facet fixation massoud-goel technique and theory for treatment of degenerative spine