Kornimate/medical-research-clean huggingface dataset:
treatment of myofascial pain syndrome with lidocaine injection and physical therapy.

Conditions: Myofascial Pain Syndrome; Pain; Myofascial Trigger Point Pain; Musculoskeletal Pain

Summary: background: myofascial pain syndrome (mps) of the shoulder girdle and cervical region is a common musculoskeletal problem that is often chronic or recurrent. it has demonstrated the effectiveness of different treatments such as exercise, injection but not comparing them with each other. the objective of this research was to demonstrate whether lidocaine injection into trigger points combined with a physical therapy program was more effective than each separatetreatment in improving pain, function and quality of life in a group of patients with myofascial pain syndrome (mps) of the shoulder girdle and cervical region. design: single-blind, randomized, controlled clinical trial with three parallel groups in the departments of physical medicine and rehabilitation of two urban hospitals. there were 127 patients with myofascial pain in the shoulder girdle for more than six weeks in length and pain greater than 40 mm on the visual analog scale (vas). there were three intervention groups: physical therapy (pt), lidocaine injection (li), or the combination of both (pt + li). the primary outcome at one month was the vas, and the secondary outcomes were measured using the sf36 pain scaleat one and three months. keywords: myofascial pain, trigger points, lidocaine injection, physical therapy.

we propose a double blind randomized controlled clinical trial, in different health centers in medellin. the subjects are patients with myofascial trigger points (mtp) in muscles of the shoulder girdle (levator scapulae, trapezius, infraspinatus) diagnosed by neck ans shoulder pain lasting langer than 6 weeks, and that have not received rehabilitation treatment and are not currently taking analgesic medications. we have calculated a sample of 45 patients in each group. the physical and rehabilitation doctors who evaluated the patients and the nurse who assessed the patients were blinded to treatment allocation. physicians who performed the mtp injection did not participate in the evaluation of primary and secondary outcomes. physical therapists who conducted the therapeutic exercise program did not participate in the evaluation of primary and secondary outcomes.

Eligibility criteria:
inclusion criteria: * cervical pain at least six weeks * at least 40 mm in the vas * they cannot been received treatment like physical therapy or analgesics * maximum score of phq 16 points exclusion criteria: * depression * fibromyalgia * cervical radiculopathy

Keywords: myofascial pain trigger points. lidocaine injection. physical therapy
firibastat in treatment-resistant hypertension

Conditions: Hypertension

Summary: this is a double-blind, placebo-controlled, multicenter, efficacy and safety study of firibastat (qgc001) administered po bid over 12 weeks in male and female subjects ≥18 years of age at screening, with uncontrolled primary htn. subjects will be randomized 1:1 to investigational product (ip) and will receive either firibastat (qgc001) or matching placebo on top of their current chronic antihypertensive treatments.

the primary objective of this study is to assess the effects of administration of firibastat (qgc001) 500 mg oral (po) twice daily (bis in die \[bid\]) on blood pressure (bp) over 12 weeks in subjects with uncontrolled primary htn.

Eligibility criteria:
inclusion criteria: * men and women ≥18 years of age at screening * diagnosis of primary htn for at least 6 months prior to screening exclusion criteria: * known or suspected secondary htn (eg, hyperaldosteronism, renovascular htn, pheochromocytoma, cushing's disease). * automated office sbp \>180 mmhg or dbp \>110 mmhg at the screening or inclusion visit (visit 2, day 1) and confirmed by a second measurement within 30 minutes to 1 hour. * known hypertensive retinopathy (keith-wagener grade 3 or grade 4) and/or hypertensive encephalopathy.
project hera (health, education, and relationship-building for adolescents- moms and tots)

Conditions: Child Behavior Problems; Parenting Skills; Obesity Prevention

Summary: specific aims: 1. the primary aims of this study are to conduct formative interviews with teen mothers to inform a targeted adaptation of empirically based weight management and parent training programs for teen mothers for their preschoolers. 2. to conduct a small pilot and post-pilot focus group of the feasibility and acceptability of recruitment and retention methods \& the intervention. study hypotheses: given the small sample size and fact that this is a pilot study, focus will be on estimating effect sizes rather than statistical hypothesis testing. however, the investigators exploratory hypotheses are as follows: 1. (a) the adapted intervention will be more feasible compared to the wellness control condition, with a participant retention rate of ≥80% and an average adherence (attendance at weekly treatment sessions; homework completion 5 weekdays weekly) is ≥ 75%; (b) the adapted intervention will be more acceptable compared to the wellness control condition, based on the consumer satisfaction scale and therapy assessment inventory with ≥90% of the participants responding to the item, "in general how satisfied were you with the intervention?" by choosing "unsatisfied" to "very satisfied." 2. (a) the adapted intervention will result in greater improvements in child behavior and parent-child connectedness compared to the control condition; (b) the adapted intervention versus wellness control condition will result in greater increases in child and teen mother individual as well as joint physical activity and physically active play and greater reductions in individual and joint teen mother and child sedentary behavior (television viewing) from baseline to post-intervention; (c) the greater teen mother and child fruit and vegetable consumption; and reduced child juice and sugar-sweetened beverage consumption from baseline to post-intervention; (d) the adapted intervention versus wellness control condition will result in smaller increases in child bmi percentile and teen mother bmi from baseline to post-intervention; (e) participants who attend higher numbers of intervention sessions will show greater improvements in target outcomes (child behavior, parent-child connectedness, and teen mother and child physical activity, sedentary behavior and bmi); with participants receiving the adapted intervention versus wellness control showing the greatest dose-based improvements.


Eligibility criteria:
inclusion criteria: * must be teen moms * be between 16 and 20 years of age exclusion criteria: * does not have a child between the ages of 6 months and 5 years

Keywords: obesity adolescents, females child development weight loss programs child rearing parenting
detection of neoplastic tissue in barrett's esophagus with in vivo probe-based confocal endomicroscopy

Conditions: Barrett Syndrome; Barrett's Syndrome; Barrett's Esophagus; Barrett Esophagus; Adenocarcinoma

Summary: this study will collect data from patients routinely undergoing a endoscopic surveillance and cellvizio endomicroscopy procedure due to confirmed barrett's esophagus. the objective is to determine if endomicroscopy images collected using the marketed cellvizio device may help endoscopists more accurately diagnose, in conjunction with traditional tissue sampling techniques, whether a suspected lesion is malignant or benign.

this is a longitudinal observational study were imaging procedures are allocated in a random order to directly address the low sensitivity and specificity of enhanced macroscopic endoscopic imaging devices by determining whether probe-based confocal laser endomicroscopy (pcle), as a supplement to narrow band imaging (nbi) can further improve sensitivity and specificity to a level that would be acceptable to avoid random biopsy, and better direct biopsy of suspicious areas. the study is also addressing pcle as a supplement to standard white light endoscopy and random biopsy alone. in fact, the study is powered to evaluate per lesion sensitivity and specificity of confocal imaging as applied to lesions identified by white light endoscopy. therefore, the study addresses the shortcomings of standard white light endoscopy (high number of random biopsies, less than ideal directed biopsy of suspicious areas) and the primary shortcomings of narrow band imaging (nbi) (low specificity with resultant high false positives, again resulting in many unnecessary biopsies).

Eligibility criteria:
inclusion criteria: 1. patients with documented or suspected barrett's esophagus presenting for endoscopy 2. age \> 18 years 3. ability to provide written, informed consent exclusion criteria: 1. presence of erosive esophagitis 2. inability to obtain biopsies due to anticoagulation, varices, etc. 3. allergy to fluorescein, pregnancy 4. presence of an esophageal mass other than small 10mm or less nodules 5. renal insufficiency

Keywords: barrett's esophagus esogastroduodenoscopy barrett's carcinoma adenocarcinoma cellvizio endomicroscopy random biopsy
characterization of pulmonary microbiome in cystic fibrosis patients

Conditions: Cystic Fibrosis

Summary: the composition and role of the pulmonary microbiota is not yet well described in cystic fibrosis patients. the objective of our longitudinal follow-up of primary colonised patients is to show the presence of a link between the composition of the microbiota and the effectiveness of antibiotic therapy. all patients followed at the montpellier cf center will be asked to participate in this cohort. all patients have a regular follow-up every 1 to 6 months and will be asked at each visit to keep their sputum sample in excess of the analyses requested for their follow-up

the composition and role of the pulmonary microbiota is not yet well described in cystic fibrosis patients. according to our hypothesis, the lung microbiota shapes the lung environment of cystic fibrosis patients and modifies the effectiveness of antibiotic treatments and the course of the disease. the objective of our longitudinal follow-up of primary colonised patients is to show the presence of a link between the composition of the microbiota and the effectiveness of antibiotic therapy. finally, the management of first colonisations could justify the characterisation of the microbiota in order to develop innovative diagnostic tests for the follow-up of patients suffering from cystic fibrosis and possibly the identification of new therapeutic agents based on the microbiota. all patients followed at the montpellier cf centre will be asked to participate in this cohort. all patients have a regular follow-up every 1 to 6 months and will be asked at each visit to keep their sputum sample in excess of the analyses requested for their follow-up.

Eligibility criteria:
inclusion criteria: - cystic fibrosis patient exclusion criteria - refusal to participate in this research

Keywords: microbiology multi-omic sputum pulmonary microbiota cystic fibrosis cohort antibiotherapy
community point distribution of insecticide treated bed nets

Conditions: Malaria

Summary: all households in three zones in zambia's eastern province were invited to attend a community point distribution of insecticide treated bed nets (itns). households were then randomized to different intervals for a community health worker (chw) hang-up visit.

households were asked to attend a community point distribution of itns in one of three zones in zambia's eastern province. households that had been registered to receive itns were then randomized to one of five groups that received a chw visit at different intervals. group 1 was visited 1-3 days after distribution, group 2 was visited 5-7 days after, group 3 was visited 10-12 days after, group 4 was visited 15-17 days after, and group 5 did not receive a hang-up visit. groups 1-4 were categorized as having received a hang-up visit and group 5 was categorized as not having received a hang-up visit. all households in all five groups were visited at 7-11 weeks after the distribution and again at 5-6 months after the distribution to assess short- and medium-term itn retention and usage.

Eligibility criteria:
inclusion criteria: * household was pre-registered by the national malaria control centre to receive itns ahead of the start of study activities. * household was located in one of the three study areas of mukonka, lukwipa, and chipeketi in rufunsa district, zambia exclusion criteria: * household was not pre-registered to receive itns * household was not located in one of the three study areas

Keywords: itns malaria prevention
effect of probiotics in patients undergoing surgery for periampullary neoplasms

Conditions: Periampullary Carcinoma Nos

Summary: the purpose of this study is to evaluate the effect of the probiotic use in patients with periampullary cancers undergone curative or palliative treatment considering nutritional status, postoperative complications, infection rate, length of hospitalization and mortality.


Eligibility criteria:
inclusion criteria: * patients in need of surgery for periampullary cancer exclusion criteria: * patients submitted to periampullary surgery without pathologic confirmation of cancer * patients unwilling to be a part of the trial

Keywords: periampullary cancer surgery dietary supplementation nutritional assessment
bone microcirculation after extracorporeal shock wave therapy

Conditions: Intact Scaphoid Bone; Intact Metacarpal Bone; Fractured Scaphoid Bone; Fractured Metacarpal Bone

Summary: in trauma surgery and hand surgery treatment strategies of none healing bone fractures aim at replacing pseudarthrosis by well vascularized bone and improving microcirculation. although previous studies indicate that extracorporeal shock wave therapy (eswt) can accelerate bone healing in case of non-union, only a few studies focused on the elucidation of its mechanisms of action. therefore, the aim of this study is to evaluate the microcirculatory effects of extracorporeal shock wave therapy on scaphoid bones and metacarpal and metatarsal in a human in-vivo setting for the first time.


Eligibility criteria:
inclusion criteria: * group a (n=20): consent-capable male and female patients ≥18 years of age who have an intact scaphoid. * group b (n=20): consent-capable male and female patients ≥18 years of age who have an intact metacarpal bone. * group c (n=20): consent-capable male and female patients ≥18 years of age who have a fractured scaphoid. * group d (n=20): consent-capable male and female patients ≥18 years of age who have a fractured metacarpal bone. exclusion criteria: * below 18 years of age * scar tissue above scaphoid or metacarpal bone * osteoporosis or comparable bone disease * medication that influences bones
breast cancer pathways program impact on patient shared decision making and experience in academic and community practice

Conditions: Anatomic Stage IV Breast Cancer AJCC v8; Breast Carcinoma; Metastatic Breast Carcinoma; Prognostic Stage IV Breast Cancer AJCC v8; Recurrent Breast Carcinoma

Summary: this trial studies the impact of the breast cancer pathways program on the patient experience, including decision making and quality of life. measuring how the breast cancer pathways program affects decision making and quality of life in patients may help doctors improve cancer education.

primary objectives: i. evaluate the impact of breast cancer pathways on patient experience, burden of decision making and quality of life in tertiary cancer center and community oncology practice. ii. identify modifiable factors that affect provider adoption of breast cancer pathways in tertiary cancer center and community oncology practice. outline: participants are assigned to 1 of 2 groups. group i: participants receive standard chemotherapy educational materials. participants also complete surveys over approximately 22 minutes at the time of first chemotherapy infusion, and approximately 8 weeks after first chemotherapy infusion. group ii: participants receive personalized information about their cancer, treatment, and side effects. participants also complete surveys over approximately 22 minutes at the time of first chemotherapy infusion, and approximately 8 weeks after first chemotherapy infusion.

Eligibility criteria:
inclusion criteria: * treatment includes intravenous chemotherapy for breast cancer for primary disease as neoadjuvant or adjuvant therapy, or for recurrent and/or metastatic cancer * can provide consent * are able to comprehend written materials in english or spanish * will receive their chemotherapy at roswell park sites in buffalo or amherst, new york (ny), or roswell park oncology primary care (pc) sites in niagara falls, amherst, west seneca, or jamestown ny exclusion criteria: * breast cancer patients receiving oral therapy alone * patients who are not able to comprehend written materials in english or spanish * patients who will not receive chemotherapy at a roswell park site * patients who are not able to comprehend written materials will not be included in this study, as the consent document will be administered in multiple infusion centers that cannot be all staffed daily with a research associate. the study instruments used are standardized tools that have been developed as best as possible with appropriate literacy levels * patients enrolled in clinical trials for their breast chemotherapy will be excluded from this study because they will require alternative educational materials that are specific to the trial drugs being administered
long term glucose metabolism in conservatively treated patients with congenital hyperinsulinism

Conditions: Conservatively Treated CHI Patients

Summary: the purpose of this study is to continue follow up of conservatively treated chi patients and to focus on their metabolic outcome, including frequency of hypoglycemia after discontinuing treatment and incidence of diabetes mellitus in the long term.


Eligibility criteria:
inclusion criteria: * conservatively treated chi patients who are in remission for at least one year exclusion criteria: * none
a phase i dose escalation study of sgn-35 alone and in combination with gemcitabine for cd30-positive malignancies

Conditions: Disease, Hodgkin; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin

Summary: this study will examine the safety profile of sgn-35 alone and in combination with gemcitabine. the study will test increasing doses of sgn-35 given weekly to small groups of patients.


Eligibility criteria:
inclusion criteria: * histologically confirmed cd30-positive hematologic malignancy. * patients with hl must have failed systemic chemotherapy. * patients with other cd30-positive malignancies (including alcl) must be beyond first remission or refractory to front line chemotherapy. * patients must have measurable disease of at least 1.5 cm as documented by radiographic technique. exclusion criteria: * current diagnosis of primary cutaneous alcl (systemic alcl eligible). * history of allogeneic stem cell transplant. * patients who have had previous treatment with any anti-cd30 antibody.

Keywords: antigens, cd30 antibody-drug conjugate antibodies, monoclonal monomethyl auristatin e combined modality therapy drug therapy immunotherapy lymphoma, non-hodgkin disease, hodgkin lymphoma, large-cell, anaplastic hematologic diseases lymphoma
3d evaluation of powerscope appliance in treatment of skeletal class 2 malocclusion

Conditions: Class II Malocclusion, Division 1

Summary: the study is aiming to evaluate the efficacy of powerscope appliance in treatment of skeletal class 2 malocclusion by three-dimensional image. powerscope appliance is a hybrid fixed functional appliance used for treatment of class ii malocclusion with a retruded mandible.


Eligibility criteria:
inclusion criteria: 1. healthy post pubertal female patients of age range 14 to 16 years old, manifesting features of post pubertal cervical vertebrae maturational stages 4, 5 and 6 (deceleration, maturation, and completion). 2. skeletal class 2 malocclusion of anb angle greater than 4° with retrognathic mandible. 3. class ii division 1 malocclusion with at least an end-on class ii molar relationship. 4. presence of all permanent dentition excluding third molars. 5. good oral hygiene. exclusion criteria: 1. history of previous orthodontic treatment. 2. any systemic disease that could affect the orthodontic treatment. 3. patients with periodontal diseases. 4. patients with temporomandibular disorders.
post-breast procedure pain syndrome study

Conditions: Breast; Mastectomy, Segmental

Summary: the purpose of this study is to better understand and characterize the pain that some patients experience after undergoing various breast surgeries, including breast biopsy, lumpectomy, mastectomy, mastectomy with reconstruction, cosmetic breast augmentation, and breast reduction.

post-operative breast pain is one of the most common adverse effects after breast surgery procedures. according to previous studies, anywhere from 20-60% of breast surgery patients report mastalgia as an adverse outcome of surgery (1, 2). although the exact mechanism has not been well defined, the pain is generally neuropathic in nature and described as a burning sensation, electric and shock like, with a stabbing quality (2,3). the large majority of post-operative mastalgia is therefore believed to be secondary to nerve damage, particularly injury to the intercostobrachial nerve, and less commonly the long thoracic, medial and lateral pectoral, and/or the thoracodorsal nerves. other reported causes of post-operative breast pain include scarring pain, lymphedema, radiation plexopathy, and hematomas (1-5). increasing rates of breast surgeries, whether elective, diagnostic, prophylactic, or therapeutic, warrant a more detailed examination of this pain-syndrome, particularly as previous research in the area is rather limited and narrow. a better understanding of the potential mechanisms causing pain, as well as more accurate and current incidence rates, and comparisons of adverse outcomes among the various options available to patients can help guide physicians towards improved clinical practices and patients towards more informed decision-making. therefore, we designed this prospective cohort study to better understand the underlying mechanisms which may cause post-operative pain after various types of breast surgeries including breast biopsy, lumpectomy, mastectomy, mastectomy with reconstruction, cosmetic augmentation, and breast reduction, as well as to compare and contrast incidence, quality, and distribution of the post-operative pain caused by these various surgical procedures.

Eligibility criteria:
inclusion criteria: * patients scheduled to undergo one or more of the breast surgical procedures being studied for this project * willingness and ability to sign an informed consent document * no allergies to anesthetic or analgesic medications * female, * 18-80 years of age * asa class i-iii adult exclusion criteria: * patients with known allergy, hypersensitivity or contraindications to anesthetic or analgesic medications * patients with clinically-significant medical conditions, such as brain, heart, kidney, endocrine, or liver diseases, or history of chronic pain syndrome or neuropathy. * subjects with a history of alcohol or drug abuse within the past 3 months * subjects with a history of pain medication abuse * any other conditions or use of any medication which may interfere with the conduct of the study

Keywords: pain management radical mastectomy breast surgery post-operative pain