Kornimate/medical-research-clean huggingface dataset:
assisted promontofixation using glue versus promontofixation using threads (procol)

Conditions: Prolapse

Summary: the treatment of gynecological prolapse (organ removal) can be done by laparoscopy or vaginally. laparoscopy is used in 1 out of 2 cases, but learning is difficult and operation time is long. one of the technical difficulties is related to the sutures to the threads. some surgeons therefore use a glue to fix prosthetic reinforcements more easily and quickly, but this sizing technique has only been evaluated very little. our study proposes to compare the technique of suture with the thread at the gluing of the prostheses in order to validate the merits of this new technique

laparoscopic promontofixation is a surgical technique considered by some as the reference technique. its difficulty of learning and the duration of operation are factors limiting its diffusion. the use of cyanoacrylate glue is proposed to simplify the procedure, without there being any comparative studies between the sutures over and the sizing of prosthetic reinforcements. the main objective of the study is to compare the operative time of promontofixation by coelioscopy with suture using threads to promontofixation using glue. secondary objectives are the comparison between the two groups of complications per and postoperative, objective anatomical results and functional results of the tissue reaction judged by clinical examination (palpation) and ultrasound and direct cost.

Eligibility criteria:
inclusion criteria: 1. age\> 40 years 2. surgical indication of prolapse cure by promontofixation 3. valid social insurance 4. french spoken and written 5. informed consent signed 6. no exclusion criteria exclusion criteria: 1. concomitant rectopexy 2. concomitant hysterectomy 3. associated surgical procedure not compatible with measurement of operative time 4. refusal to participate in the study 5. pregnant or lactating woman (article l 1121-5 of the french code of public health) 6. vulnerable persons (article l 1121-6 of the french code of public health) 7. majors subject to legal protection or unable to express their consent (article 1121-8 of the csp) 8. participation in another protocol for less than 3 months 9. patient does not have all the inclusion criteria.

Keywords: promontofixation prolapse surgery
hyaluronic acid in counteracting aphthous stomatitis

Conditions: Aphthous Stomatitis

Summary: oral mucosal ulcers can determine a real worsening of the quality of life. conventional therapy usually lasts not less than 2-3 weeks, and carries a high risk of serious side effects; furthermore, ulcers often recur. the use of hyaluronic acid applied as an adhesive gel over the lesions seems to have potential in terms of efficacy and the avoidance of side effects. of course, hyaluronic acid-based formulations show different effects and tolerability. in this retrospective observational study, the results obtained using a hyaluronic-acid based medical device applied for 14 days to counteract ulcers in adults will be reported.


Eligibility criteria:
inclusion criteria: * diagnosis of aphthous stomatitis * healthy for other conditions excluding aphthous stomatitis exclusion criteria: * taking one of the following in the 45 days prior to the beginning of the study: immunosuppressive, cytotoxic, cortisone, antibiotic, antifungal, hormone therapy (including birth control pills).

Keywords: mucositis oral ulcers chlorhexidine aloe barbadensis rosa damascena
the effects of aerobic exercise in microvascular endothelium function in patients with cardiovascular diseases

Conditions: Cardiovascular Diseases

Summary: this study evaluates the effects of different volumes of aerobic exercise training in cardiovascular parameters of patients with cardiovascular diseases enrolled in a cardiac rehabilitation program.

aerobic exercise training is well known to improve endothelium dependent vasodilatation in the microcirculation. however, the impact of exercise frequency on this response in patients with coronary artery disease remains unclear.

Eligibility criteria:
inclusion criteria: * sedentarism for at least 6 months; * clinical diagnosis for coronary artery disease (occurrence of any acute coronary syndrome, including st elevation or non-st elevation myocardial infarction or unstable angina or by the diagnosis of obstructive coronary artery disease on coronary angiography in patients with stable angina). exclusion criteria: * nephropathies; * decompensated cardiovascular diseases; * liver diseases.
study of high dose cyclophosphamide in patients with severe aplastic anemia and paroxysmal nocturnal hemoglobinuria

Conditions: Aplastic Anemia; Paroxysmal Hemoglobinuria, Nocturnal

Summary: objectives: i. confirm the efficacy demonstrated in a pilot study using high dose cyclophosphamide in patients with severe aplastic anemia. ii. determine whether the addition of filgrastim (g-csf) to high dose cyclophosphamide shortens the time to recovery in these patients. iii. determine whether this regimen is efficacious in treating paroxysmal nocturnal hemoglobinuria.

protocol outline: patients receive high dose cyclophosphamide iv on days 1-4. beginning on day 10, patients receive filgrastim (g-csf) until the absolute neutrophil count is greater than 1,000/mm3 for 2 consecutive days. patients are followed every 3 months for at least 2 years and annually thereafter.

Eligibility criteria:
protocol entry criteria: --disease characteristics-- * acquired severe aplastic anemia or paroxysmal nocturnal hemoglobinuria * not a candidate for allogeneic bone marrow transplantation * must meet one of the following criteria: * severe aplastic anemia * less than 25% bone marrow cellularity and depression in two of three blood counts (reticulocytes less than 40,000/mm3 * platelet count less than 20,000/mm3 and granulocytes less than 500/mm3) * life-threatening paroxysmal nocturnal hemoglobinuria * absolute neutrophil count less than 500/mm3 * platelet transfusion dependent * thrombotic disease * no fanconi anemia * no abnormal cytogenetics --patient characteristics-- * renal: creatinine no greater than 2.0 mg/dl * cardiovascular: cardiac ejection fraction at least 45% * other: not preterminal or moribund not pregnant

Keywords: aplastic anemia hematologic disorders paroxysmal nocturnal hemoglobinuria rare disease
rct of mobile apps & fitbit v. usual care

Conditions: Pancreatic Cancer; Gastric Cancer; Hepatic Cancer; Colon Cancer; Rectal Cancer; Small Bowel Cancer

Summary: this is a randomized clinical trial to evaluate the use of mobile devices in preventing readmission in patients undergoing major gi cancer operations.

patients will be randomized to 1) standard of care or 2) to use our mobile app with standard care. the mobile app will collect information on patients' daily physical activity patterns and health status data for clinicians using smartphone mobile technology applications. the investigators believe that by tracking information on patients, the investigators may be able to intervene sooner and prevent a delay in care.

Eligibility criteria:
inclusion criteria: 1. subject is 18 years or older 2. subject speaks english 3. subject owns a smart phone 4. subject is scheduled to undergo surgery for a gi cancer (pancreatic, hepatic, gastric, small bowel, colon, or rectal cancers) exclusion criteria: 1. physician deems the subject is unable to complete the study due to documented dementia 2. subject is undergoing emergent surgery 3. subject has sepsis from another source 4. physician deems the subject is unable to complete the study due to documented alcohol and/or drug abuse
the roshni project - developing a psychosocial intervention

Conditions: Mood Disorders

Summary: the mental health sector is being called upon to develop and implement interventions for youth that attend to gender, age and cultural diversity (mental health commission of canada, 2016). the proposed project outlines the development and feasibility testing of a culturally driven transdiagnostic psychosocial intervention for south asian women aged 16-24 years. we will recruit 30 participants to complete the 12 week psychosocial intervention. pre, midpoint and post evaluations will be completed to asses change in mental health, self esteem and values, and also qualitative feedback on participant experiences of the intervention.


Eligibility criteria:
inclusion criteria: * aged 16-24 years * identify as a woman * ancestry connected to india, pakistan, bangladesh and sri lanka * formal diagnosis of mood or anxiety disorder * completed high-school in canada * reside in the greater toronto area * speak conversational english exclusion criteria: • individuals with developmental disabilities and serious mental illness e.g. schizophrenia spectrum, bipolar and personality disorders.

Keywords: cultural relevance cultural adaptation south asian gender
dwibs-mri: an adjunct to the traditional diagnostic breast imaging evaluation

Conditions: Breast Cancer

Summary: 1.1. primary objectives * to determine if mri dwibs can accurately identify suspicious lesions previously categorized on mammography and sonography as potentially malignant. * we will also validate whether dwibs-mri adc values can be used to accurately differentiate benign from malignant lesions. additionally, because it is not known whether tumor type or growth rate (ki67 values) will affect our results, we will include these parameters in our analysis. * once we validate the use of dwibs-mri adc values to determine malignancy, can we establish an adc threshold value to decrease the number of false positive biopsies that are performed while still maintaining a zero false negative rate? * this study will also assess the correlation between adc values and the ki-67 proliferative index of malignant lesions.


Eligibility criteria:
inclusion criteria: * a patient will be eligible for inclusion in this study if she meets all of the following criteria: 1. \>30 years of age 2. genetic female 3. suspected diagnosis of birads 4 or birads 5 masses and/or asymmetries greater than 1 centimeter based on standard 2d/3d mammogram and ultrasound imaging. exclusion criteria: * a patient is ineligible for inclusion in this study if she meets any of the following criteria: 1. prior biopsy of suspicious lesion 2. breast implants 3. prior history of breast cancer 4. patient has a pacemaker 5. contraindications to use of mri imaging (metal implants, etc.) 6. woman pregnant or lactating 7. calcifications as only findings present for a suspicious lesion
linear programming approach to develop local specific food-based complementary feeding recommendation

Conditions: Stunting; Anemia; Complementary Feeding Recommendation; Linear Programming; Indonesia; Infant and Young Children; Problem Nutrients

Summary: stunting and anemia amongst under-two children are attributable to poor nutrient intakes. the study evaluates the effectiveness of nutrition education on local specific food-based complementary feeding recommendation (cfr) to improve dietary patterns and nutritional intakes, as well as reduce stunting and anemia among under-two children.


Eligibility criteria:
inclusion criteria: * 6-11 months old at baseline * living in selected area during the study * apparently healthy * willing to take part in the study and taken venous blood sample by getting signed consent from parents exclusion criteria: * the child does not present during venous blood sample collection
halaven post-marketing surveillance (pms)

Conditions: Breast Cancer

Summary: this is a pms to observe the safety profile of halaven in normal clinical practice setting.


Eligibility criteria:
participants who are prescribed with halaven per approved prescribing information of halaven will be enrolled in the study. this study will be conducted as complete surveillance method; participants who meet the inclusion/exclusion criteria and administrate halaven for the first time after conclusion of agreement will be enrolled after consent. inclusion criteria: participants who meet all of the following criteria will be eligible for inclusion in the study: 1. participants with following indication: participants with locally advanced or metastatic breast cancer who have previously received at least two chemotherapeutic regimens which should have included an anthracycline and a taxane. 2. participants who have verbal or written consent for use of personal and medical information. investigators will refer to indications regarding inclusion criteria. exclusion criteria: 1. hypersensitivity to the active substance or to any of the excipients 2. breast feeding 3. pregnancy investigators will refer to indications and contraindications regarding exclusion criteria.

Keywords: halaven eribulin mesylate locally advanced or metastatic breast cancer
different molecular subtypes of peripheral t-cell lymphoma, a real-world registry study. (trust)

Conditions: Peripheral T Cell Lymphoma

Summary: a multi-center, prospective, registry study to analyze the clinical characteristics and prognosis of different molecular subtypes of peripheral t-cell lymphoma.

peripheral t-cell lymphoma (ptcl）is a distinct and heterogeneous histopathologic subtype of non-hodgkin lymphoma (nhl), accounting for \~10%. patients with ptcl still have poor treatment response and prognosis under conventional chop regimen. this multi-center, prospective, registry study is designed to analyze the clinical characteristics and prognosis of different molecular subtypes of ptcl. the results can guide future precision therapy for ptcl.

Eligibility criteria:
inclusion criteria: * patients diagnosed with peripheral t-cell lymphoma (ptcl) by histopathology from june 2023 to december 2026 and detected by gene sequencing (ngs) with different molecular subtypes. * patients diagnosed with ptcl by histopathology from january 2023 to june 2023 and ngs detection can be performed if there is tumor tissue. * informed consented * age ≥ 18 years exclusion criteria: * history of malignancy except for basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix prior to study treatment * uncontrollable cardio-cerebral vascular, coagulative, autoimmune, serious infectious disease * not able to comply to the protocol for mental or other unknown reasons * patients with mentally disorders or other reasons unable to fully comply with the study protocol * pregnant or lactation

Keywords: peripheral t cell lymphoma molecular subtypes
comparing ketamine and fentanyl in pediatric tonsillectomy: pain control and emergence delirium outcomes (kvfpt)

Conditions: Postoperative Pain, Acute; Emergence Delirium

Summary: this study is designed to compare the effectiveness of two medications, ketamine and fentanyl, in managing pain and preventing delirium in children aged 3 to 8 years who are undergoing tonsillectomy and adenoidectomy surgery. the study aims to determine which medication is better at reducing pain and preventing delirium after surgery, and which one results in faster recovery times and fewer side effects. children participating in the study will be randomly assigned to receive either ketamine or fentanyl during their surgery. the study will measure pain levels, recovery times, and any side effects experienced by the children. the results of this study will help doctors and anesthesiologists make better decisions about which medication to use for pain management in children undergoing tonsillectomy and adenoidectomy.


Eligibility criteria:
inclusion criteria: * children aged 3 to 8 years * scheduled for tonsillectomy and adenoidectomy * american society of anesthesiologists (asa) physical status i-iii exclusion criteria: * american society of anesthesiologists' physical status ≥4 * known hypersensitivity or allergy to any of the study medications (acetaminophen, ketamine, fentanyl) * receiving chronic opioid analgesic therapy prior to surgery * renal disease * hepatic disease * obesity (body mass index greater than 99th percentile for age)

Keywords: tonsillectomy, adenoidectomy, postoperative pain management, emergence delirium, ketamine, fentanyl
safety of menacwy-crm vaccination in adolescents

Conditions: Meningococcal Disease

Summary: the purpose of this us fda post-marketing commitment study is to evaluate the safety of menacwy-crm among 50.000 vaccinated adolescents within a large us healthcare maintenance organization who received menacwy-crm vaccination as part of their routine clinical care. the pre-specified 26 events of interest are events commonly evaluated in vaccine safety studies and include certain neurological, immunological, vascular, musculoskeletal and hematologic disorders. all events are collected retrospectively.

this is an observational study, vaccines administration and data that is collected is only as part of routine clinical care. vaccinated subjects are not actively recruited. events of interest: seizure, aseptic meningitis, bell's palsy, multiple sclerosis, guillain-barre syndrome, acute disseminated encephalomyelitis, cerebellar ataxia, transverse myelitis, brachial neuritis, hashimoto's disease, systemic lupus erythematosis, henoch schonlein purpura, new onset juvenile diabetes mellitus, rheumatoid arthritis, idiopathic thrombocytopenic purpura, iridocyclitis, acute glomerulonephritis, nephrotic syndrome, grave's disease, autoimmune hemolytic anemia, myasthenia gravis, new onset asthma, allergic urticaria, anaphylaxis, meningococcal disease, suicide attempt.

Eligibility criteria:
inclusion criteria: 1. enrolled in the hmo for at least 6 months prior to vaccination 2. between the ages of 11 and 21 years (inclusive - i.e. has not reached their 22nd birthday) at the time of the vaccination. 3. received the vaccine during the study period exclusion criteria:

Keywords: observational serogroup a, b, y, w meningococcal meningitis meningococcal vaccines safety menacyw-crm post-marketing adolescents
clinical profile and outcome of perforated pud

Conditions: Diseases or Conditions

Summary: perforated peptic ulcer disease (ppud) is series illness that need emergency intervention. its overall clinical profile and treatment outcome was also not well studied in developing countries. therefore the study was aimed to see the outcome of surgical intervention and associated factors. the study was a retrospective observational study conducted using the medical records of patients operated on for perforated peptic ulcer disease at a multicenter, in eastern ethiopia.

this study was designed to investigate the clinical characteristics and treatment outcomes among adult patients presented to the study areas. three teaching hospitals and one regional hospital were chosen and data collection was effected for two years. one hundred seventy patients participated in this observational study.

Eligibility criteria:
inclusion criteria: * all adults with a diagnosis of perforated pud managed at hu until discharged exclusion criteria: * patients who were referred to other institutions before official discharge, incomplete medical record
a pilot study of physical activity for improving quality of life in prostate cancer patients on androgen deprivation therapy (adt)

Conditions: Prostate Cancer

Summary: 60 eligible subjects will be randomized into one of three study arms 1) aerobic exercise, 2) resistance exercise, or 3) usual care. baseline measurements will be done on all study subjects, these measurements include: height, weight, dual energy x-ray absorptiometry (dxa) for bone mineral density and lean body mass measurements, blood will be taken to measure serum free testosterone, prostate-specific antigen (psa), glucose, and insulin levels. fitness will also be evaluated using a graded exercise test. questionnaires on health and personal history will also be completed. men randomized to the aerobic exercise treatment arm will participate in a walking program three times a week for eight weeks. the participants will start at 15 minutes per session and increase to a goal of 60 minutes per session. men randomized to the resistance training treatment arm will participate in an eight-week program of eight strength training exercises three times per week. men in the usual care arm will receive written materials from the american cancer society about coping with cancer, which includes information about participation in physical activity. at the end of the eight week intervention participants in all three study arms will complete the same questionnaires and measurements they completed at baseline.


Eligibility criteria:
inclusion criteria: * men with metastatic prostate cancer receiving adt and men who have failed primary therapy and are receiving adt. * men from the radiology practice who are receiving adt as neoadjuvant therapy to primary radiotherapy (enrolled only following completion of primary radiotherapy). exclusion criteria: * men with the following counter-indications to exercise: * lower limb, bone, muscle, or joint pathology of a severity which limits their ability to be physically active. * a history of significant cardiac disease using criteria established by the american college of sports medicine ( criteria: pain, discomfort in the chest, neck, jaw, arms, or other areas that may be due to ischemia; shortness of breath at rest or with mild exertion; ankle edema; palpitations or tachycardia; known heart murmur; unusual fatigue or shortness of breath with usual activities' syncope) * other medical contraindications which would compromise participation in a lifestyle physical activity program. * those who are currently physically active

Keywords: prostate cancer aerobic exercise resistance training