Kornimate/medical-research-clean huggingface dataset:
the health-related quality of life of the patients with symptomatic convergence insufficiency

Conditions: Myopia; Convergence Insufficiency

Summary: this trial is an observational cohort study. patients aged 8-15 years with symptomatic convergence insufficiency and 150 patients with symptomatic convergence insufficiency who had not received visual training were selected from the tianjin eye hospital optometry center and received 1 course of visual training treatment. self-assessment and other assessments were combined, and the patient and guardian questionnaires were collected. the eq-5d-y and chu9d scales were used to evaluate chinese patients' health-related quality of life with symptomatic convergence insufficiency. the feasibility of the eq-5d-y and chu9d scales in assessing the health-related quality of life of chinese patients with symptomatic convergence insufficiency was analyzed. to assess the effectiveness of visual training on visual symptoms and improvement of quality of life in patients with symptomatic convergence insufficiency


Eligibility criteria:
inclusion criteria: * 8\~15 years old * monocular best corrected visual acuity at distance and near was more than 0.8 * near exophoria 4δ greater than distance exophoria * npc ≥ 6cm * pfv ≤15△bo * stereogram ≤500 '' * score of ciss questionnaire ≥16 or covd questionnaire≥20 exclusion criteria: * present constant strabismus, nystagmus or vertical phoria at distance or near. * developmental delay or ocular surgery * myopia≤ -6.00d, hyperopia ≥ +5.00d, astigmatism ≥ 4.00d * monocular amplitude of accommodation\<5d * other diseases except myopia
project fit:a school- and community-based obesity intervention

Conditions: Obesity

Summary: project fit is a collaboration between the public school system, local health systems, physicians, neighborhood associations, businesses, faith-based leaders, community agencies and university researchers to develop a multi-faceted approach to promote physical activity and healthy eating toward the general goal of preventing and reducing childhood obesity among children in grand rapids, mi, usa. there are four overall components to project fit: school, community, social marketing, and school staff wellness - all that focus on: 1) increasing access to safe and affordable physical activity and nutrition education opportunities in the schools and surrounding neighborhoods; 2) improving the affordability and availability of nutritious food in the neighborhoods surrounding the schools; 3) improving the knowledge, self-efficacy, attitudes and behaviors regarding nutrition and physical activity among school staff, parents and students; 4) impacting the 'culture' of the schools and neighborhoods to incorporate healthful values; and 5) encouraging dialogue among all community partners to leverage existing programs and introduce new ones.


Eligibility criteria:
inclusion criteria: * enrolled in participating school district in grades 1-5. exclusion criteria: * none

Keywords: physical inactivity poor diet
polecat: perioperative delta renin concentration

Conditions: Post Operative Vasoplegic Syndrome; Acute Kidney Injury

Summary: we want to measure the amount of a hormone called renin in people's bodies before and after they have major abdominal surgery. we want to see if changes in renin levels are connected to problems with blood flow, unstable blood pressure, and kidney damage after surgery.

the renin-angiotensin system (ras) plays a key role in haemodynamic stability, vascular tone and electrolyte homeostasis. it is recognised that this system is dysfunctional during critical illness. it remains unknown as to whether significant dysfunction of ras is found in patients who have undergone major abdominal surgery - however over 50% of these patients often require blood pressure support post-operatively, with nearly half of these patients having unexplained drops in blood pressure. renin represents an attractive biomarker that could be implicated in post operative vasoplegia and post operative aki and as such elevated renin concentrations could be used to identify high-risk patients for cardiovascular instability and aki who would benefit from timely intervention that could improve their outcomes, this would include the use of selective vasopressor agents such as angiotensin ii which has been shown to confer a benefit in patients with underlying dysregulation of the ras. if we show that higher differences in renin concentrations are associated with a greater incidence of vasoplegia then we can design a subsequent clinical trial with a different treatment in those who have a higher change in renin. such a trial is currently recruiting in germany for patients with higher changes in renin due to cardiac surgery. the primary aim is to assess whether there is an association between higher differences in renin concentrations (a protein that can be measured in your blood) and haemodynamic instability manifest as vasoplegia (patients exhibiting low blood pressure) in patients undergoing major abdominal surgery requiring post-operative admission to icu.

Eligibility criteria:
inclusion criteria: * age ≥18 years * all patients having abdominopelvic surgery (planned or unplanned) needing icu admission where arterial line or central line will been placed * able to provide consent, or personal/professional agreement exclusion criteria: * patient \< 18 years old at time of screening * patients already receiving vasopressor support pre-operatively * receiving palliative care at the time of recruitment or expected to die within next 24 hours * those on kidney replacement therapy (krt) or end stage kidney disease (eskd) * patient or consultee unable to communicate in verbal and written english * patients held in an institution by legal or official order * patients with severe mental health disorders that might impair their capacity
bivalirudin/prasugrel versus abciximab/clopidogrel in patients presenting with stemi

Conditions: ST-Elevation Myocardial Infarction; Primary Percutaneous Coronary Intervention

Summary: in the setting of st elevation myocardial infarction newer therapies has been recently studied and, following encouraging results, introduced into the clinical practice. prasugrel showed to be a valid alternative to overcome limitation of clopidogrel therefore providing a better ischemic protection. on the other hand, bivalirudin is at least as beneficial as heparin/abciximab as anticoagulant agent but associated with fewer hemorrhagic events. the primary hypothesis of the study is that the combination of prasugrel plus bivalirudin can be associated with a better risk/benefit profile.

background: in the setting of stemi, adjunctive pharmacological therapy plays a key role in the acute management. along with the clear benefit of mechanical reperfusion strategies, several drugs showed to be beneficial. on top of clopidogrel, heparins and iib/iiia glycoprotein, other drugs have been recently introduced showing encouraging results. these "new" drugs, namely prasugrel and bivalirudin, have only been compared separately. primary hypothesis: the combination of prasugrel/bivalirudin is superior to the combination of clopidogrel and heparin/abciximab in terms of net adverse clinical events, i.e. ischemic events plus hemorrhagic events setting: - patients presenting with st-elevation myocardial infarction undergoing primary pci mechanical reperfusion: -primary percutaneous coronary intervention pharmacological interventions: - two arms: clopidogrel plus heparin/abciximab vs prasugrel plus bivalirudin follow up: - 1 year measurements: * efficacy end points in terms of reduction of ischemic events * safety end points in terms of reduction of bleeding events

Eligibility criteria:
inclusion criteria: * st elevation myocardial infarction * no contraindication to primary pci exclusion criteria: * known intolerance/allergy to one of the study drugs or their components * clinical indication to treatment with oral anticoagulant, including use of warfarin or dabigatran or other oral anticoagulant agents

Keywords: stemi primary pci anticoagulants antiplatelets
falls prevention program for adults with osteoarthritis

Conditions: Osteoarthritis; Falls, Accidental

Summary: purpose: to report the feasibility and to obtain preliminary data on the effects of using an enhanced otago exercise programme to reduce fall risk in individuals with osteoarthritis (oa). participants: ten participants from the johnston county osteoarthritis project who have oa, are at risk for falls, and are 65+ years old. procedures (methods): all participants will receive the 6-month enhanced otago program. the investigators will assemble data: quantifying participant adherence to and safety of the intervention, ascertaining retention of participants for 6 months, determining acceptability of the program, and other validated measures (e.g., number of falls and fall severity, balance measures).


Eligibility criteria:
inclusion criteria: * history of falls * knee or hip radiographic oa * 65+ years of age * normal cognitive function (based on the mini-mental state examination) * current knee/hip symptoms exclusion criteria: * hospitalized for stroke, myocardial infarction, or coronary artery revascularization in past 3 months * diagnosis of metastatic cancer in the past 3 months * terminal illness * progressive neurological disorders * rheumatoid arthritis * severe fibromyalgia * other systemic rheumatic disease
preoperative intravenous iron therapy in patients with gastric cancer

Conditions: Gastric Cancer; Anemia; Surgery; Iron Deficiency Anemia; Surgery--Complications

Summary: the main objective of this investigator initiated study is to study if preoperative intravenous iron is effective in reducing need for allogenic blood transfusion in patients with gastric cancer who will undergo a standardized gastrectomy including both total and subtotal gastrectomies. the hypothesis is that intravenous iron reduces the need for perioperative blood transfusions.


Eligibility criteria:
inclusion criteria: - patients with gastric cancer who will undergo a gastrectomy exclusion criteria: * patients under 18 years old * patients not in full understanding * hemoglobin levels \> 155 g/l for women and \>167 g/l for men (upper reference limits for the laboratory of helsinki university hospital district) preoperatively. * transferrin saturation level \>50% * emergency gastrectomy * palliative gastrectomy * acute bacterial infection * known hypersensitivity to the active substance, to ferric carboxymaltose or any of its excipients, or to other parental iron products * clinical evidence of iron overload or disturbances in the utilisation of iron * patients \<35 kg * dialysis therapy for chronic renal failure * hemochromatosis * polycythemia vera * pregnancy * patients in need of direct blood transfusion ( criteria for this are hemoglobin \< 80 g/l or \< 90 g/l if the patient is symptomatic or has a history of heart disease)
cell free dna profiling as a tool to monitor clinically-relevant events in allogeneic hematopoietic stem cell transplantation

Conditions: GVHD - Graft-Versus-Host Disease; Infections After HSCT; Transplant Associated Microangiopathy TAM; Sinusoidal Obstruction Syndrome (SOS); HSCT Engraftment

Summary: allogeneic hematopoietic stem cell transplantation (hsct) is a life-saving treatment for people with severe blood-related diseases. however, it comes with serious risks, including a condition called graft-versus-host disease (gvhd), where the transplanted cells attack the patient's body. gvhd can occur in about 50% of patients acutely and 35% in a chronic form, potentially affecting organs like the skin, liver, and gastrointestinal system. currently, doctors diagnose gvhd based on symptoms, as there are no easy tests available. infections can also be a problem after hsct, as dormant viruses may reactivate. these infections are monitored using specialized tests. additionally, doctors use advanced methods, like analyzing minimal residual disease (mrd) and chimerism, to check for the risk of the original disease coming back. mrd is tracked by looking for specific genetic markers of the disease in the patient's blood or bone marrow. another emerging tool involves analyzing cell-free dna (cfdna)-tiny fragments of dna found in bodily fluids that come from dying cells. this technique, called liquid biopsy, has been revolutionary in areas like cancer detection, pregnancy testing, and organ transplants. for example, in organ transplants, cfdna can indicate early signs of rejection, helping reduce the need for invasive biopsies. in hsct, the use of cfdna to monitor complications like gvhd or relapse has not been fully explored. this pilot study aims to investigate whether analyzing cfdna using a technique called epigenomic profiling can help detect acute gvhd, as well as other post-transplant issues like infections, disease relapse, and chronic gvhd. the goal is to compare cfdna analysis to current testing methods to see if it offers better or earlier detection of complications. this research could pave the way for improved, less invasive monitoring of hsct patients, potentially leading to better outcomes and fewer complications.


Eligibility criteria:
inclusion criteria: * patient must be affected by an hematological malignancy requiring hematopoietic stem cell transplantation (hsct). exclusion criteria: * patients can not be 17 years old or yunger

Keywords: cfdna methylation epigenetic profile hsct liquid biopsy
covid-19 and reorganisation of cancer patient care: self- evaluation of potential post-traumatic stress disorder

Conditions: Cancer

Summary: the covid-19 pandemic is a traumatic event which could lead to a greater risk of developing post-traumatic stress disorder, especially in cancer patients who feel more at risk of contracting the virus, and fear developing serious symptoms. the study's primary objective is to measure the presence of a potential post-traumatic stress disorder in cancer patients, and to assess the associated factors. the secondary objectives are to measure patients' anxiety, as well as their perception of both the management of their cancer care, and their fear of a cancer recurrence. it is a prospective, multi-centric study using self-assessing survey offered to cancer patients currently under ongoing care or treatment. the surveys will be sent by post at the beginning of the study, and again 6 months later. expecting a participation rate of 40%, 4000 patients will be contacted, over a period of 3 months, in order to receive 1600 responses, and 640 responses 6 months later. researching the factors associated with the appearance of post-traumatic stress could lead to better screening of patient disorders in highly anxiety-provoking crisis situations. as a result, it would lead to an improvement of their care, healthcare organization, and their follow-up in the case of a new epidemic or any other stressful event of this magnitude. furthermore, promoting the patient's expression capabilities favors their implication in their care, and facilitates the development of health democracy.


Eligibility criteria:
inclusion criteria: * man or woman, age\>18 * diagnosis of cancer (solid tumor or hematology) * out patient or patient under surveillance exclusion criteria: * refusal to participate in the study * emergency, person deprived of liberty * hospitalized patient

Keywords: covid-19 post traumatic stress cancer anxiety reorganisation of care
advent trial long term outcomes evaluating atrial fibrillation progression study

Conditions: Paroxysmal Atrial Fibrillation

Summary: the (advent lto) is an observational, non-significant risk study to assess the progression of atrial fibrillation in subjects who received ablation treatment with either the farapulse pulsed field ablation system or thermal ablation in the advent trial.

this study is an observational, non-significant risk study. subjects who participated in the farapulse advent trial (nct04612244) will be approached for participation.

Eligibility criteria:
inclusion criteria: * subjects who meet all of the following criteria may be given consideration for inclusion in this clinical investigation. * subjects who were enrolled, randomized and treated for paroxysmal atrial fibrillation, classified as modified intention-to-treat subjects, and completed the 12-month follow-up in the farapulse advent trial (cip cs0934; nct04612244). * subjects or legally authorized representatives who are willing and capable of providing informed consent. * subjects who are willing to comply with the protocol requirements. exclusion criteria: * there are no exclusion criteria for this study.

Keywords: persistent atrial fibrillation pulsed field ablation cardiovascular heart diseases antiarrhythmic anticoagulation cardiac monitor atrial fibrillation atrial flutter atrial tachycardia
a study of enlicitide decanoate (mk-0616 oral pcsk9 inhibitor) in adults with heterozygous familial hypercholesterolemia (mk-0616-017) coralreef hefh

Conditions: Hypercholesterolemia; Familial Hypercholesterolemia

Summary: the goal of this study is to evaluate the efficacy, safety, and tolerability of enlicitide decanoate in adult participants with heterozygous familial hypercholesterolemia. the primary hypothesis is that enlicitide decanoate is superior to placebo on mean percent change from baseline in low-density lipoprotein cholesterol (ldl-c) at week 24.


Eligibility criteria:
inclusion criteria: * has possible or definite diagnosis of heterozygous familial hypercholesterolemia (hefh) based on a locally accepted diagnostic algorithm * has an ldl-c ≥55 mg/dl or ≥70 mg/dl depending on medical history * is treated with a moderate- or high-intensity statin medication * is on a stable dose of all background lipid-lowering therapies (llts) with no planned medication change exclusion criteria: * has a history of homozygous familial hypercholesterolemia (fh) based on genetic or clinical criteria, compound heterozygous fh, or double heterozygous fh * has a history of heart failure or heart failure hospitalization within 3 months before first study visit * is undergoing or previously underwent an ldl-c apheresis program within 3 months before first study visit or plans to initiate an ldl-c apheresis program * was previously treated/is being treated with certain other cholesterol lowering medications, including protein convertase subtilisin/kexin type 9 (pcsk9) inhibitors
st segment detection study

Conditions: Coronary Artery Disease

Summary: the purpose of st detect study is to evaluate whether naturally occurring spontaneous coronary events and exercise induced cardiac ischemia, give rise to detectable changes on intracardiac electrogram (egm) signals in patients that are indicated for an implantable cardioverter defibrillator (icd) who have coronary artery disease.


Eligibility criteria:
inclusion criteria: * subject is indicated for an icd implantation * and subject must meet one of the following: * prior acute coronary event * previously underwent percutaneous coronary intervention (pci) or stent procedure * multivessel disease * positive stress test completed with evidence of ischemic heart disease, as determined by physician, and no subsequent successful revascularization exclusion criteria: * subject is currently dependent on ventricular pacing * subject has left bundle brunch block (lbbb) and/or wide qrs * subject has chronic atrial fibrillation (af) * subject has dementia * subject is indicated for a single chamber device * subject requires a right sided or abdominal icd implant * subject is pregnant or in fertile age without secure birth control * subject has new york heart association (nyha) class iv or refractory heart failure * subject is not expected to survive greater than 12 months * subject is participating in other confounding research studies

Keywords: cardiac ischemia st segment elevated myocardial infarction (stemi) non-st segment elevated myocardial infarction (nstemi) implantable cardioverter defibrillator (icd) cardiac electrogram (egm) coronary artery disease (cad)
ckd-ap among adults on dialysis in switzerland

Conditions: Chronic Kidney Diseases; Dialysis; Chronic Kidney Diseases Associated Pruritus

Summary: chronic kidney disease associated pruritus (ckd-ap) represents a localized or a generalized skin itch, which is a common symptom occurring in end-stage renal disease and dialysis. the prevalence of ckd-ap in adults on dialysis varies between countries ranging between 20-42%. swiss data on ckd-ap are unfortunately largely lacking, as switzerland is so far not part of large registries, such as dopps. the aging population, the increase in diabetes (69% by 2030), the increase in hypertension (60% by 2025) and poly-morbidity will probably lead to a rise in the number of patients on dialysis and subsequent ckd-ap. ckd-ap is associated with sleep disturbances, compromised quality of life, emotional distress, and increased risks of hospitalization and death. its management lacks approaches that are supported by strong evidence because its pathogenesis remains poorly understood and may be related to an increase in uremic toxins, skin inflammation. in this context, sweat composition deserves more attention. aim of the study the aim of the study is to determine the prevalence of ckd-ap in the population on dialysis, the association between ckd-ap and different electrolytes, and the potential role of the composition of sweat in ckd-ap. results will be used for building a ckd-ap symptom management program to improve the quality of care of patients on dialysis and will be incorporated in the nursing continuing education program.


Eligibility criteria:
inclusion criteria: * adult ≥ 18 years old * diagnosed with end-stage renal disease and receiving hemodialysis for at least 6 months * able to communicate in french or availability of a french-speaking close relative for translation * signed informed consent additional inclusion criteria for the case-control study outcomes phase 2: * reporting moderate to severe ckd-ap for the participant considered as a case * reporting no or mild ckd-ap for the participant considered as a control cases and controls will be matched by age-group, sex, and dialysis modality (hemodialysis or peritoneal dialysis). exclusion criteria: * presence of cognitive impairment or cognitive disorder

Keywords: chronic kidney disease; dialysis; pruritus