Kornimate/medical-research-clean huggingface dataset:
dry needling and kinesio taping in the treatment of myofascial pain syndrome

Conditions: Myofascial Pain Syndrome of Neck

Summary: the aim of this study is to compare the effectiveness of kinesio tape and dry needling in the treatment of myofascial pain syndrome of the trapezius muscle.

myofascial pain syndrome (mps) is a common problem with manifesting itself such as trigger points, taut bands, range of motion limitations and pain. one of the most common place for mps is neck region and trapezius muscle is the common cause of these symptoms and 9 different trigger point location has been identified on trapezius muscle. myofascial trigger points, characterized by hypersensitive nodules, can be palpated in stretched bands in the affected muscles. in order to eliminate trigger points fascial releasing, dry needling, kinesio taping and other physical therapy applications can be used. although there are several studies investigating the effectiveness of kinesio taping (kt) and dry needling(dn) methods in mps, it is controversial which one is superior to others. the aim of this study is to compare the effects of exercise, kt, and dn methods on pain and disability in the treatment of upper trapezoidal muscle mps.

Eligibility criteria:
inclusion criteria: * being diagnosis with mps and having active myofascial trigger points on trapezius muscle exclusion criteria: * fibromyalgia * a history of myofascial trigger point injection * acute trauma * inflammatory joint or muscle disease * infection or malignancy on cervical region * neurological disorders * cervical radiculopathy or myelopathy * inadequate cooperation for the treatment * a history of neck surgery or spinal degeneration

Keywords: taping pain trigger point dry needling
assessment of a oral endotracheal tube fastener on patients intubated with oral endotracheal tubes

Conditions: Respiratory Depression; Respiratory Failure; Ventilatory Depression

Summary: assessment of anchorfast guard oral endotracheal tube fastener on patients intubated with oral endotracheal tubes with subglottic suction

endotracheal intubation is the trans laryngeal placement of a tube into the trachea via the nose or mouth. subglottic suctioning, during endotracheal tube securement, is important for mechanically-ventilated patients to allow for the clearance of secretions that may accumulate during intubation. this protocol examines an enhancement to the current anchorfast guard device in order for the device to hold a subglottic suctioning lumen in addition to the intubation tube.

Eligibility criteria:
inclusion criteria: * is 18 years of age or older and requires oral tracheal intubation * has intact skin on application site * is qualified to participate in the opinion of the investigator including the requirement for endotracheal tube with subglottic suction exclusion criteria: * has an existing neck injury * has protruding upper teeth, is without teeth or is unable to wear upper dentures * has facial hair * has clinically significant skin damage, condition or disease on the application site which may contraindicate participation * has a known or stated allergy to adhesive bandages, or any of the product types being tested * uses of topical drugs, lotions, creams or oils on the application site * is participating in any clinical testing which may affect performance of this device * anchorfast guard oral endotracheal tube fastener does not fit subject's face
the covid home study: prospective cohort study of non-hospitalised covid-19 patients

Conditions: COVID-19; Post-COVID-19 Syndrome

Summary: background. guidelines on covid-19 management are developed as we learn from this pandemic. however, most research has been done on hospitalised patients and the impact of the disease on non-hospitalised and their role in transmission are not yet well understood. the covid home study conducts research among covid-19 patients and their family members who were not hospitalised during acute disease, to guide patient care and inform public health guidelines for infection prevention and control in the community and household. methods. an ongoing prospective longitudinal observational study of covid-19 outpatients was established in march 2020 at the beginning of the covid-19 pandemic in the netherlands. laboratory confirmed sars-cov-2 infected individuals of all ages that did not merit hospitalisation, and their household (hh) members, were enrolled after written informed consent. enrolled participants were visited at home within 48 hours after initial diagnosis, and then weekly on days 7, 14 and 21 to obtain clinical data, a blood sample for biochemical parameters/cytokines and serological determination; and a nasopharyngeal/throat swab plus urine, stool and sperm or vaginal secretion (if consenting) to test for sars-cov-2 by rt-pcr (viral shedding) and for viral culturing. weekly nasopharyngeal/throat swabs and stool samples, plus a blood sample on days 0 and 21 were also taken from hh members to determine whether and when they became infected. all participants were invited to continue follow-up at 3-, 6-, 12- and 18-months post-infection to assess long-term sequelae and immunological status.

an ongoing prospective longitudinal observational study of sars-cov-2 infected individuals that did not require hospitalisation and their hh members was initiated on march 2020, at the start of the pandemic in the netherlands. enrolled individuals comprised the identified laboratory covid-19 index positive patients plus all their hh members. the average number of hh inhabitants in the netherlands and the northern region is 2.14 \[44\], thus for each enrolled patient we expected to enrol an average of 1-2 hh members in addition. patients were followed daily at home approximately during 3 weeks post-infection to characterize their acute clinical phenotype, and are currently being followed at 3, 6, 12 and 18 months to determine their long-term clinical and serological evolution. during the follow-up, clinical data and different types of samples were/are collected, as described below.

Eligibility criteria:
inclusion criteria: * onset of symptoms \<5 days before inclusion * positive diagnostic rt-pcr for sars-cov-2 performed within 48h of inclusion * index person should supply all required samples in the protocol for the duration of the study * all hh members should join the study * signing of informed consent form exclusion criteria: * false positive rt-pcr test * non compliance with study follow-up

Keywords: covid-19 sars-cov-2 non-hospitalised post-covid-19 syndrome
bioavailability of proteins from plant based diets

Conditions: Protein Malabsorption; Nutritional Deficiency; Nutritional Stunting

Summary: proteins play an important role as structural and functional components for the human body and prevent stunting. protein quality has a great importance in meeting the nutritional needs of populations across the world throughout the life course, particularly during pregnancy and early childhood. dietary protein deficiency is mainly due to protein indigestibility limiting indispensable amino acids (iaas) bioavailability. in morocco, as it's the case in many developing countries, diet is mainly based on a large consumption of cereals, fruits, vegetables and pulses, and is generally low in meat, which is the main source of protein and iaa. the general objective of this study is to evaluate the digestibility of fava bean proteins and bioavailability of iaa using a dual-tracer method with stable isotopes.

this study aims to develop stable isotope labeled protein of bean cultures that could be used for other local common foods, to quantify dietary indispensable amino acids from beans made available to the body for optimal growth, development and function and to participate in the development of a simple method to assess protein quality in vulnerable populations. the project is divided in two parts: the first part of harvesting and production of deuterium labeled fava beans. the optimization test done the first year has shown that the best protocol for labelling was a pulse with 25% d2o followed with subsequent labeling with 2.5% d2o during 20 days. the second part is the intervention stuy that is going to be conducted on 6 healthy volunteers (3 males, 3 females). each participant will receive a test meal containing 13c labelled spirulina, 2h labelled fava bean and 13c phenylalanine. the test meal will be divided on 11 subdoses: 3 sub-doses will be administrated at t0 and 1 subdose will be administrated at 1, 2, 3, 4, 5, 6 and 7h. the remaining sub-dose will be kept for measurement of iaa in the test meal. after eating the test meal, blood, urine and breath samples will be collected from each participant at the baseline (t0) and after 5-6, 7h and 8h.

Eligibility criteria:
inclusion criteria: healthy, non-pregnant adults 18-65 years of age not taking any medication, including nsaids not taking antibiotics within 4 weeks of study bmi within 18-35 range stable weight exclusion criteria: children and elderly (over 65) pregnancy diagnosed with non-communicable or communicable disease being under restrictive diet antibiotics within 4 weeks of study medications within 4 weeks of study

Keywords: proteins digestibility bioavailability indispensable amino acids plant-based food plant diet nutrition food security fava bean vegetal proteins
a study of routine versus selective use of ultrasound scanning prior to haemodialysis fistula surgery

Conditions: End Stage Renal Failure; Surgery

Summary: dialysis patients have their blood filtered by a machine as their kidneys no longer work. to get blood in and out of these patients it is possible to perform a surgical procedure to increase to size and durability of a vein in the arm to allow repeated needle insertion. this enlarged vein is called a fistula. there is some evidence that ultrasound scanning the blood vessels in the arm before surgery can improve the chances of a successful procedure. the investigators aim to test whether scanning all patients is better than scanning only those who are difficult to assess by physical examination alone.

we will recruit all patients undergoing primary vascular access procedures in our unit who meet inclusion criteria. they will be randomised to either surgery based on clinical findings with duplex ultrasound only if requested by surgeon, or routine duplex ultrasound prior to surgery.

Eligibility criteria:
inclusion criteria: * specific inclusion criteria necessary for invitation to study participation; patients referred to vascular consultants for primary av fistula formation (or primary fistula in that limb) for haemodialysis access. general inclusion criteria; * ability to give informed written consent exclusion criteria: * specific exclusion criteria; * previous arterial or venous surgery/intervention performed on target limb. * known thrombophilic or thrombotic pathology. * aged under 18 at time of referral general exclusion criteria; * inability to give informed written consent * inability to attend follow up appointments

Keywords: fistula ultrasound angioaccess preoperative vein mapping haemodialysis angioaccess surgery
comparative study of ceftazidime-avibactam versus standard of care as therapy in febrile neutropenic adults with cancer

Conditions: Neoplasms; Febrile Neutropenia

Summary: this study will evaluate the effect, safety, and tolerability of ceftazidime-avibactam (caz-avi) plus vancomycin or linezolid compared to standard of care plus vancomycin or linezolid as empiric therapy in febrile neutropenic adults with cancer


Eligibility criteria:
inclusion criteria: * patients with neutropenic fever who have existing malignancy or have undergone hematopoietic stem cell transplantation * requires hospitalization for intravenous (iv) empiric antibiotic therapy exclusion criteria: * fungal or viral infection requiring additional therapy * known acute viral hepatitis * known to be human immunodeficiency virus (hiv) positive * expected requirement for hemodialysis while on study therapy * received \>24 hours of systemic antibacterial therapy within 72 hours of initiation of inpatient iv study drug * past or current history of epilepsy or seizure disorder * evidence of immediately life-threatening disease, progressively fatal disease, or life expectancy of 3 months or less.
pain, central sensitization and psychoemotional state in patients with chronic masticatory muscle pain

Conditions: TMD

Summary: the aim of this study is to investigate the relationship of psychological aspects, selected blood parameters, pain, central sensitization, and muscle electromyography activity in patients with chronic masticatory muscle pain.

in this prospective cohort study, the study group will consist of 51 people with masticatory muscle pain lasting longer than 3 months, while the control group will involve 51 people without such disorder. muscle type of temporomandibular disorders will be diagnosed on the basis of validated and standardized dc/tmd protocol. additionally potential headaches will be assessed according to the ichd-3, since coexistence of chronic masticatory muscle pain and headache is often observed. psychological aspects will be analyzed using validated questionnaires regarding depression (phq-9), anxiety (gad-7), perceived stress (pss-10), satisfaction with life (swls), type d personality (ds-14) and coping with stress (mini-cope). central sensitization will be assessed using the central sensitization index and determination of following blood substances: serotonin, dopamine, acetylcholine, adrenaline, noradrenaline, cortisol, parathyroid hormone, crp, fibrinogen, interleukin 1b, interleukin 6 and interleukin 8. additionally the level of electrolytes in the blood (mg, ca, na, k) and level of phosphate will be measured. pain assessment will be done using a validated and standardized questionnaire regarding chronic pain (gcps) and an algometer and will include the measurement of pressure pain threshold in masseter and temporal muscles. in addition, potential autonomic disorders will be assessed using autonomic symptoms questionnaire proposed by low. electromyographic muscle activity will be assessed by tetany test. the results of the study will allow for deeper understanding of the complex nature of orofacial pain of muscle origin and its connection with the mechanism of central sensitization, headache and muscle electromyographic activity. measurement of blood parameters will provide more accurate information on the pathophysiology of these disorders and the use of validated questionnaires will provide valuable information about the mental state of patients.

Eligibility criteria:
inclusion criteria for study group: * masticatory muscle pain for at least 3 months, based on dc/tmd, at least 18 y.o exclusion criteria: * severe neurological or psychiatric diseases, use of drugs that may affect the neuromuscular system, alcohol or drug addiction, cancer or pregnancy, previous head surgery inclusion criteria for control group: * no pain in masticatory muscles, age of at least 18 y.o exclusion criteria the same as for study group

Keywords: tmd, masticatory muscle pain, central sensitization
circulating biomarkers in oropharyngeal cancers

Conditions: Oropharynx Squamous Cell Carcinoma; Oropharynx Cancer; Tonsillar Cancer; Base of the Tongue Carcinoma

Summary: the goal of this observational longitudinal study is to learn about circulating tumor human papilloma virus-dna (cthpv-dna) as a biomarker for hpv positive oropharyngeal cancer and cancer of unknown primary of the head and neck. the main questions it aims to answer are: * can cthpv-dna be used for treatment evaluation in hpv positive oropharyngeal cancer and cancer of unknown primary of the head and neck? * can circulating hpv-dna be used as a biomarker for recurrent disease during surveillance? participants will be asked to leave plasma samples at diagnose, at the end of treatment and at every clinical follow-up. the patients are there own controls.

in the multicenter study of circos, circulating biomarkers in oropharyngeal cancer, patients with oropharyngeal cancer or cancer of unknown primary of the head and neck are consecutively included. plasma samples are collected at diagnosis, at the end of treatment and during surveillance after treatment. at diagnose participants will fill in informed consent and a form regarding known risk factors for cancer. tissue from the tumor will be analyzed for hpv genotype with a multiplex q-pcr. information about p16 will be collected from medical records. cthpv-dna are short dna fragments that leaks into the blood stream from tumor cells during apoptosis and necrosis. in the study, cthpv-dna will be extracted from blood plasma. levels of cthpv-dna (copies/ml) will be measured using digital droplet pcr (ddpcr) with genotype specific assays (based on the result of q-pcr at diagnose) used in singleplex (saga diagnostics). a negative sample after treatment will be defined as a good molecular response for evaluation after treatment. two consecutive, positive samples during surveillance will be defined as molecular recurrence. if a molecular recurrence is seen patients will be contacted and offered an extra clinical control at an ear nose and throat department. if a patient is hpv negative in tissue, the tissue will be analyzed with whole genome sequencing. if a mutation is found, a personalized ddpcr-kit will be used for plasma. all patients will be followed for five years.

Eligibility criteria:
inclusion criteria: * oropharyngeal cancer * cancer of unknown primary in the head and neck exclusion criteria: * previous treatment of cancer in the oropharynx. * previous treatment of unknown primary tumor. * remote metastases * patients unwilling or unable to comply with the study protocol and follow-up schedule

Keywords: circulating tumor dna hpv human papilloma virus
use of insulin glargine to treat diabetic ketoacidosis

Conditions: Diabetic Ketoacidosis

Summary: the purpose of this study is to determine the effects of the addition of insulin glargine during the early phase of moderate to severe diabetic ketoacidosis (dka) in children. the investigators hypothesize that the addition of insulin glargine during the early phase of management of dka will accelerate acidosis correction, decrease the length of insulin infusion, and decrease the total intensive care unit time in children admitted to the icu.


Eligibility criteria:
inclusion criteria: * ages 6-18 y.o. presenting to vanderbilt children's hospital (vch) emergency room with: * established history of insulin dependent diabetes and: * chief c/o hyperglycemia or vomiting * venous ph \< 7.24 * serum bicarbonate \< 18 * blood glucose \> 150 * urinary ketones exclusion criteria: * age \< 6y.o. * new onset diabetes * received iv insulin bolus prior to arrival to vch emergency room (er) * venous ph \> 7.24 * serum bicarbonate \> 18 * pregnancy * received glargine within 12 hours prior to arrival to vch emergency room/pediatric critical care unit

Keywords: pediatrics diabetes emergency care endocrinology critical care
early supportive care and nutritional support in adults with pancreatic cancer

Conditions: Pancreatic Cancer

Summary: the purpose of the study is to assess the feasibility and patient satisfaction with the support through remote observation and nutrition guidance (strong) program. the program provides nutrition and supportive care for participants living with pancreatic cancer who are receiving chemotherapy.


Eligibility criteria:
inclusion criteria: * ≥18 years old * newly diagnosed metastatic or newly recurrent pancreatic cancer or locally advanced pancreatic cancer * planning to initiate chemotherapy under the guidance of moffitt * able to speak and read english or spanish * able to provide informed consent exclusion criteria: * documented or observable psychiatric or neurological disorder that would interfere with study participation (e.g., psychosis, active substance abuse) * undergoing concurrent treatment for a second primary gi cancer * ecog status of 2 or greater * receipt of chemotherapy in the past 6 months for recurrent pancreatic cancer * use of parenteral or enteral nutrition * presence of malignant ascites * the last two exclusion criteria were included because investigators do not anticipate that these patients would benefit from additional nutrition intervention.

Keywords: nutritional support
gastric cancer prevention in the family members by helicobacter pylori eradication

Conditions: Gastric Cancer; Helicobacter Pylori Infection; Family Members

Summary: this study evaluate whether treatment of helicobacter pylori infection reduces the incidence of gastric cancer in subjects with family history of gastric cancer.

helicobacter pylori infection is associated with gastric cancer in epidemiological studies. however, it is still unknown whether h. pylori eradication is useful and required to prevent gastric cancer. gastric cancer risk is increased in family members of gastric cancer patient. though there is no direct evidence that h. pylori infection is a risk factor for gastric cancer in family members of gastric cancer, current european guideline recommends h. pylori eradication in first-degree relatives of gastric cancer patients. in this study, the investigators will evaluate whether h. pylori eradication can reduce gastric cancer risk in the first-degree family members of gastric cancer patients.

Eligibility criteria:
inclusion criteria: * sibling or offspring of patients with gastric adenocarcinoma confirmed by egd and biopsy * informed consent should be signed exclusion criteria: * gastric cancer history * other malignancy within the past 5 years * hereditary cancer family member (hnpcc, fap) * peptic ulcer history * peptic ulcer, esophageal cancer, gastric cancer case found at egd * h. pylori eradication treatment history * previous serious side effect to antibiotics * serious concurrent infection or nonmalignant disease such as liver cirrhosis, renal failure, cardiovascular diseases * pregnant or nursing women * psychiatric disorder that would preclude compliance, alcoholics * refuse informed consent

Keywords: stomach neoplasm helicobacter pylori
carpal tunnel syndrome: diagnosis and treatment trial

Conditions: Carpal Tunnel Syndrome

Summary: the carpal tunnel syndrome diagnosis and treatment trial is project #1 of the multidisciplinary clinical research center focused on upper extremity pain. it is a randomized trial comparing surgical and nonsurgical treatments for patients with early, mild to moderate carpal tunnel syndrome. in addition the study will evaluate the ability of a new magnetic resonance (mr) technique at predicting who will likely benefit from carpal tunnel syndrome (cts) surgery.

while there is good evidence that patients with severe cts benefit from surgery, there is less evidence of a benefit for patients with mild to moderate disease. however, mild to moderate disease still accounts for important disability. electrodiagnostic studies (eds) have not been shown to accurately predict outcomes for patients with cts. recent advances in mr permit high-resolution neurographic imaging of the median nerve, and pilot data suggest that wrist mri might be a better predictor of outcome than eds. thus, wrist mri has the potential for playing a major role in the treatment of patients with cts. we will test two main hypotheses: 1) that select patients with early, mild or moderate cts benefit more from early surgery than with conservative therapy; and, 2) that wrist mri accurately identifies those patients more likely to benefit from surgery. we will perform a randomized, controlled treatment trial nested within a prospective cohort as our study design.

Eligibility criteria:
inclusion criteria: * paresthesias involving 2 digits on hand diagram * willingness and ability to complete interviews exclusion criteria: * evidence of denervation on eds * abnormal 2-pt discrimination or thenar atrophy * prior wrist surgery or acute external trauma * mri contraindications * metallic hardware in wrists

Keywords: carpal tunnel release mr nerve imaging wrist mri