Kornimate/medical-research-clean huggingface dataset:
greater occipital nerve block with bupivacaine for acute migraine

Conditions: Migraine

Summary: this is a randomized, sham-controlled study of greater occipital nerve block (gonb) using bupivacaine 0.5% for emergency department patients with acute migraine. patients are only enrolled if they fail first line therapy with metoclopramide.

the investigators are testing the following hypothesis: in a population of patients who present to an ed with acute migraine and have been treated with parenteral metoclopramide unsuccessfully, bilateral greater occipital nerve blocks with bupivicaine will provide greater rates of short-term and sustained headache freedom than bupivacaine injected intradermally.

Eligibility criteria:
inclusion criteria: * ed patient with acute migraine or probable migraine * fail first line therapy with metoclopramide exclusion criteria: * can't obtain consent * concern for secondary headache * skull defect * propensity for bleeding * overlying infection * pregnancy * allergy, intolerance study medication
a database for emotion analysis using physiological and psychological assessment by 40fy

Conditions: Psychological Stress; Heart Rate Variability; Mental Health Services

Summary: a comprehensive study examining the physiological, emotional and psychological aspects of stress among korean adults

a dataset for the analysis of affective states of korean adults. participants' facial and finger videos were recorded using a cell phone camera, while watching six emotion-eliciting video stimuli, each three minutes in length (two of each: neutral, positive, and negative). participants were asked to rate their emotion and arousal in terms of arousal and valence levels. the ecg data were collected using a 1-lead ecg while watching the six emotion-eliciting video stimuli. psychological assessments were conducted using self-administered scales measuring psychological status and personality.

Eligibility criteria:
inclusion criteria: * adults over the age of 19 and under the age of 45. exclusion criteria: * participants vulnerable to voluntary consent, such as those who have evidence of intellectual disability or traumatic brain injury * participants who have difficulty reading and understanding korean.

Keywords: contactless measurement of heart rate variability mobile digital mental health monitoring psychological assessment
to develop and validate a nasoendoscopic intelligent diagnostic system for nasopharyngeal carcinoma

Conditions: Otolaryngological Disease; Artificial Intelligence

Summary: nasopharyngeal carcinoma (npc) occurs at a high frequency in southern china, northern africa, and alaska, with a reported incidence of 30 cases per 100 000 in guangdong province. endoscopic examination and biopsy are the main methods used for detection and diagnosis of npc. early npc patients achieve favourable prognoses after concurrent radiotherapy and chemotherapy in compassion with advanced npc patients. here, the investigators focused on the utility of artificial intelligence to detect early npc, which based on white light imaging (wli) and narrow-band imaging (nbi) nasoendoscopic examination. having access to this unique population provides an unprecedented opportunity to investigate the effect of intelligent system on diverse nasopharyngeal lesions detection and develop a novel computer-aided diagnosis system.


Eligibility criteria:
inclusion criteria: * older than 18 years of age exclusion criteria: * refuse to sign the informed consent statement * patients who have contraindications, e.g. coagulation dysfunction, drug allergy.

Keywords: nasopharyngeal carcinoma endoscopy narrow-band imaging white-light imaging
brazilian intervention to increase evidence usage in practice - stroke (bridge-stroke)

Conditions: Acute Ischemic Stroke

Summary: phase 1: an observational study ( registry) will be conducted with the objective of documenting the practice of stroke treatment in brazilian and latin american hospitals. phase 2: a cluster randomized trial aiming to evaluate the effect of a multifaceted strategy to increase evidence based treatments usage for stroke patients. the hospitals will be randomized into two groups: the multifaceted strategy group and the usual care group.

study objective: the purpose of this study is to evaluate a multifaceted strategy to increase evidence based therapies for patients with acute ischemic stroke. study population; patients with suspected stroke or transient ischemic attack (tia) with symptoms lasting up to 24h hours. quality improvement multifaceted intervention: the strategy includes a simulation based team training, case manager, check lists, reminders and educational material.

Eligibility criteria:
patient eligibility criteria inclusion criteria: * patients over 18 years old, diagnosed with ischemic stroke (including transient ischemic attack) with symptoms lasting up to 24 hours. exclusion criteria: * patients with signs of hemorrhagic stroke, expansive lesions, central nervous system infections, and those coming from institutions that did not provide institutional approval form signed by the patients' guardians. cluster eligibility criteria inclusion criteria: * hospitals with a emergency department, with available tomography, neurologist and alteplase exclusion criteria: * hospitals that don't provide institutional authorization form

Keywords: stroke, quality improvement
acupuncture for headache post-traumatic brain injury: a feasibility study

Conditions: Post-Traumatic Headache; Traumatic Brain Injury

Summary: this study evaluates and addresses challenges to implementing an acupuncture intervention for adults who have headaches after sustaining a moderate traumatic brain injury. eligible participants will be recruited from seattle and the surrounding areas to receive weekly acupuncture for 12 consecutive weeks. participants will complete questionnaires to assess headache impact, depression, health-related quality of life, and cognitive function at the beginning of the study and every two weeks for the duration of the study. participants will participate in structured interviews after the study for their views on the acceptability and tolerability of the study protocol.


Eligibility criteria:
inclusion criteria * has a history of moderate traumatic brain injury (tbi) one to five years previously * currently under medical supervision for post-traumatic headache * have a score ≥ 3 on the patient health questionnaire 2 * have a raw summed score ≤ 6 on the promis cognitive function short form v2.0 - abilities 2a (part of promis-29+2 profile) * community-dwelling * 18 years of age and older * english speaking * able to provide voluntarily consent exclusion criteria * history of multiple tbis * history of receiving acupuncture treatment in the past six months for the primary condition of headache * an established diagnosis of ptsd * psychosis or agitation * other neurodegenerative disorders * other medical/surgical condition that precludes travel to participate in the intervention over the study duration * has an active skin lesion or acute trauma over or around the proposed acupuncture points * history of trauma to the head that currently prevents the use of acupuncture points along the midline of the scalp * persons who are pregnant * unable to provide informed consent for the research as identified as answering more than two incorrect responses on the six-item screener

Keywords: acupuncture post-traumatic headache traumatic brain injury
irreversible electroporation(ire) for unresectable portal venous tumor emboli

Conditions: Liver Cancer

Summary: the purpose of this study is to evaluate the safety and efficacy of irreversible electroporation (ire) for unresectable portal venous tumor emboli.

by enrolling patients with unresectable portal venous tumor emboli adapted to enrolled criteria, this study will document for the first time the safety and the short and long term efficacy of percutaneous or intraoperative ire for unresectable portal venous tumor emboli.

Eligibility criteria:
inclusion criteria: * liver cancer diagnosed by positive biopsy or non-invasive criteria, * liver cancer with portal venous tumor emboli, * not suitable for surgical resection or transplantation, * child-pugh class a,b * eastern cooperative oncology group (ecog) score of 0-1, * a prothrombin time ratio \> 50%, * platelet count \> 80x10\^9/l, * ability of patient to stop anticoagulant and anti-platelet therapy for seven days prior to and seven days post nanoknife procedure, * able to comprehend and willing to sign the written informed consent form (icf), * have a life expectancy of at least 3 months. exclusion criteria: * cardiac insufficiency, ongoing coronary artery disease or arrhythmia, * any active implanted device (eg pacemaker), * women who are pregnant or women of child-bearing potential who are not using an acceptable method of contraception, * have received treatment with an investigational agent/ procedure within 30 days prior to treatment with the nanoknife™ ledc system, * are in the opinion of the investigator unable to comply with the visit schedule and protocol evaluations.

Keywords: irreversible electroporation portal venous tumor emboli
the effect of self-breast examination training on the belief of breast health

Conditions: Women of Reproductive Age

Summary: the aim of the present research was to detect the effect of self-breast examination provided to women between 18 and 49 years of age and practice on the belief of women on their breast health.

the aim of this study was to investigate the effect of breast self-examination training and practice on breast health beliefs. the study was a pretest-posttest randomized controlled experimental design. women in the experimental group of the study will be provided with the training prepared by the researcher. the presentation used in the training will include information about breast cancer, breast cancer screening programs and breast self-examination. in the presentation, the steps of breast self-examination were shown step by step using visual materials. in addition to the slide presentation about breast cancer and breast self-examination, women will be trained on breast self-examination with a breast examination model using the "show first, then do it" training technique, and the accuracy will be confirmed by asking women to do it. by using the model in breast examination, it will be determined what women do right and what they do wrong during the examination. data will be collected with personal information form and champion health belief model scale.

Eligibility criteria:
inclusion criteria: * fertility process to continue * no communication problems * not having a disease that will affect perception exclusion criteria: * having been previously diagnosed with breast cancer or receiving breast cancer treatment * being diagnosed with a medical mental illness and receiving treatment for this reason * being under active treatment in hospital due to any problem

Keywords: neoplasms early detection of cancer breast neoplasms health education
efficacy and safety of infliximab biosimilar in treatment of moderate to severe psoriasis; a single-arm clinical trial

Conditions: Moderate to Severe Chronic Plaque Psoriasis

Summary: the goal of this clinical trial is to learn if infliximab biosimilar remsima works to treat moderate to severe plaque psoriasis in adults. it will also learn about the safety of the drug. the main questions it aims to answer are: does infliximab-dyyb biosimilar (remsima) works to treat moderate to severe plaque psoriasis in adults in reducing disease severity and relapses? what medical problems do participants have when taking remsima? participants will: be injected infliximab biosimilar remsima weekly for 4 weeks and then fortnightly till 24 weeks they will be followed for efficacy and safety and lab tests at week 4, 14, 24 and 52.


Eligibility criteria:
inclusion criteria: * adult patients of moderate to severe plaque psoriasis biologically naive patients exclusion criteria: * patients with active or latent tb, hepatitis b or c, hiv. immunocompromised patients due to drugs or disease. patients on systemic anti-psoriastic medications in last three months. patients with personal or strong family history of heart disease. any other medical comorbidity (hepatic or renal) or contraindication to biologic/ biosimilars.

Keywords: infliximab biosimilar, remsima, plaque psoriasis, biologics
the double burden of malnutrition among adolescents in low-income and middle-income countries

Conditions: Stunting; Thinness; Obese

Summary: individual-participant data analysis of the global school-based student health survey and health behaviour in school-aged children surveys in 57 lmics between 2003-2013.

we used the most recent global school-based student health surveys (gshs) and health behaviour in school-aged children (hsbc) surveys, with data available on height and weight. the gshs is a world health organisation (who) initiative, designed to assess health behaviours of adolescents through cross-sectional school-based surveys, across several countries using similar standardised procedures. the hsbc study are who sponsored cross-sectional school-based surveys that uses similar standardised procedures to the gshs to examine the physical and mental health of adolescents in the who european region and north america.

Eligibility criteria:
inclusion criteria: * low-income or middle-income countries with completed global school-based student health survey or health behaviour in school-aged children surveys. * adolescents aged 12-15 years * recorded sex, height and weight exclusion criteria: - high-income countries
brief admission for adolescents who self-harm

Conditions: Self-Harm, Deliberate; Suicide, Attempted; Suicidal; Non-Suicidal Self Injury

Summary: there is still no consensus on how to manage suicidal behavior in youth with recurrent self-harm at times when the risk for suicide is imminent (1). brief admission (ba) has evolved as a promising crisis intervention for adults with self-harm (2). the characteristics of ba is different from other types of admission, being focused on prevention through increased autonomy and self-care, based on structured and voluntary brief self-referrals to hospital (3). as a result of a randomized controlled trial, ba is since january 2019, continuously offered to adults with self-harm at risk for suicide in skåne (4). parallel to this clinical trial, the method has been adapted to work in a psychiatric setting for adolescents. at present 24 adolescents have access to the method in skåne. clinical experiences from staff are promising, however, the lived experiences have not been collected in a standardized way. the aim of the present study is to gather information on how ba in its present, standardized form works for adolescents, their loved ones and staff working at the ward providing ba. this will be done through semi-structured interviews with: 1. adolescents using ba and their loved ones 2. staff working at the ward providing ba. data will be analyzed with qualitative analysis (5, 6). the ultimate aim is to use these results to optimize the current standardized version of ba for adolescents in order to test in a randomized clinical trial.


Eligibility criteria:
sample 1: inclusion criteria: * adolescents with an active ba contract * at least 13 years of age. * able to consent to study participation through written and oral information. * consent from caregivers * given consent to participate exclusion criteria: * below the age of 13. sample 2: inclusion criteria: * parents to adolescents with an active ba contract * at least 18 years of age. * able to consent to study participation through written and oral information. * given consent to participate exclusion criteria: * none sample 3: inclusion criteria: * staff working with adolescents with an active ba contract * at least 18 years of age. * able to consent to study participation through written and oral information. * given consent to participate exclusion criteria: * none
video telehealth gait retraining for running-related knee pain

Conditions: Telemedicine; Running; Knee; Pain

Summary: in this randomized control trial, participants with running-related knee pain will be randomly assigned to either an intervention group or a control group. participants in the intervention group will receive a telehealth gait retraining intervention, an at-home exercise program, a return to running protocol, and standard physical therapy. participants in the control group will receive an at-home exercise program, a return to running protocol, and standard physical therapy. data will be collected before intervention, at 10-weeks, and at 14-weeks to determine efficacy of the intervention.


Eligibility criteria:
inclusion criteria: * active duty soldier or cadet between the ages of 18 to 60 years old * knee pain that occurs during and/or after running that was not due to a recent acute trauma (such as an accident or a fall) and that is a pain intensity of at least a '3' and no greater than a '7' on a numeric pain rating scale with '0' meaning "no pain" and '10' meaning the "worst possible pain" * fluent in speaking and reading english exclusion criteria: * currently on an army running limiting profile for something other than knee pain * presence of rheumatoid or neurological diseases * plans to deploy or permanent change of station (pcs) within 4 months * current lower extremity injury other than knee pain * history of traumatic knee injury (such as a surgery, ligament tear, or meniscal tear) * current pregnancy * inability to perform 20 unassisted single leg heel raises on each leg * a non-rearfoot strike pattern during running * showing signs of ligamentous instability, meniscus pathology, or knee effusion
padawan: parkinson's disease - adaptive walking assistance

Conditions: Parkinson Disease

Summary: the goal of this study is to develop and validate a haptic assistive method in order to support walking in patients with parkinson's disease, delivered to the patient's hips through a wearable robotic pelvis orthosis.

none of the existing robotic devices used for gait rehabilitation in parkinson's disease is wearable. thanks to the wearable robotic pelvis orthosis we will use, the rehabilitation sessions can take place in an ecological environment. the other advantage of the proposed assistance protocol is its adaptability: patients will feel their hips pattern to be "smoothed" by the robot, but they will keep the freedom of continuously steering their main movement variables (like stride frequency, duration, and length). a key measured metric will precisely rely on this variability between stride durations. indeed, the degree of stride-to-stride variability was shown to reflect the patient's physiological state, and to be correlated with the stage of the disease. experimental trials will be conducted to assess both the assistive (i.e. the therapy effect during the therapy itself) and rehabilitative (i.e. effect after the therapy) natures of our protocol. the second main objective of this project will be the analysis of the effects of our protocol regarding the stride-to-stride variability of patients with parkinson's disease.

Eligibility criteria:
inclusion criteria: * parkinson's disease diagnosis positive according to uk brain bank criteria * hoehn and yahr score of 1 to 3 * mini-mental state (mmse) higher than 24 * optimal drug treatment for at least 4 weeks at the time of inclusion * no contraindication to physical exercising (acsm criteria) exclusion criteria: * not being able to understand french well enough * not being in the targeted age range

Keywords: exoskeleton active pelvis orthosis
study of bgg492 in patients with chronic subjective tinnitus

Conditions: Chronic Subjective Tinnitus

Summary: this study will assess the efficacy of a two week treatment with bgg492 in patients with chronic subjective tinnitus.


Eligibility criteria:
inclusion criteria: * patients diagnosed with thi (tinnitus handicap inventory) severity grade 3, 4 or 5 (moderate, severe or catastrophic), chronic (\> 6 months and \< 36 months) subjective tinnitus * willing to abstain from activities that require focused attention, e.g. driving a car or other vehicles, operating machines or engaging in potentially dangerous activities that require focused attention and intact physical balance * willing and able to refrain from engaging in activities or work involving loud noise exposure exclusion criteria: * patients diagnosed with tinnitus of thi severity grade equal to 2 or 1 * patients with diagnosis of intermittent or pulsatile tinnitus * patients who have tinnitus as a concomitant symptom of a treatable otological disease (such as otitis media, menière's disease, otosclerosis), neurological tumors or/and have temporo-mandibular joint disorders * patients with a history of frequent middle ear infections (\> 3 infections per year during the last 3 years) * patients with diagnosed anxiety disorders, depression, schizophrenia or other significant psychiatric diseases requiring current drug treatment or patients who required treatment in the previous 3 months for these diseases. * patients with current unilateral or bilateral hearing loss of 75 db or more in one or more tested frequencies (125 hz, 250 hz, 1 khz, 2 khz, 4 khz, 6 khz, 8 khz) * patients with vestibular schwannoma * patients with a cochlear implant * patients with regular intake of central nervous system acting drugs for the treatment of tinnitus in the previous 6 months prior to initial dosing other protocol-defined inclusion/exclusion criteria may apply

Keywords: tinnitus ampa receptor antagonist
the effect of diverting the children's attention to a different point during phlebotomy

Conditions: Pain and Anxiety of Children During Phlebotomy

Summary: this study aimed to investigate the effect of diverting the children's attention to a different point during phlebotomy which is an invasive procedure with acute pain. this is a randomized controlled experimental study. the study was conducted with two groups: the intervention group (n=127) and the control group (n=129). the control group was applied to standard phlebotomy procedures. in contrast, the intervention group had a piece of equipment that looks like a blood tube in front of them during the phlebotomy process to divert their attention from the phlebotomy process to the equipment.

the equipment used for the intervention group was designed and developed by the researchers with the project support of tübi̇tak bi̇deb 2209a in 2016. it is an equipment that looks like a blood tube with a fixed arm on the right and a moving arm on the left with a total height of 80 cm. it has some answers to common questions of parents as well as the key concerns of the children " will it hurt me?"

Eligibility criteria:
inclusion criteria: * making a request for the phlebotomy * being in the 7-12 age group * having the consent of the parent * willing to participate in the research * with the history of invasive procedure * not using any medication with analgesic effect in the last 12 hours * without any communication barriers of either child or the parent * with a normal level of consciousness during the process * without the history of passing out during the phlebotomy exclusion criteria: * not being in the 7-12 age group * not having the consent of the parent * not willing to participate in the research * without the history of invasive procedure * had medication with analgesic effect in the last 12 hours * with communication barriers of either child or the parent * with an abnormal level of consciousness during the process * with the history of passing out during the phlebotomy
validation of psfs in carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: validation of the patient specific functional scale in patients with carpal tunnel syndrome


Eligibility criteria:
inclusion criteria: * diagnosis of carpal tunnel syndrome exclusion criteria: -