Kornimate/medical-research-clean huggingface dataset:
circulating micrornas and adverse cardiovascular outcomes in patients with coronary artery disease

Conditions: miRNA

Summary: coronary artery disease (cad) resulting from atherosclerotic obstruction of epicardial coronary arteries accounts for more than one-third of deaths in subjects over the age of 35 worldwide. the global incidence of cad is on the rise owing to the international epidemic of obesity, type 2 diabetes and aging, all of which are potent risk factors for coronary atherosclerosis. participants with cad are at high risk for subsequent adverse cardiovascular (cv) events and death; it has been estimated that one out of every five cad patients will experience at least one adverse cv event during a 5-year follow up period. there is, however, no reliable diagnostic tool to predict the risk of adverse cv events or death in participanrs with cad. increasing evidence suggests that mirnas are stably present in serum, plasma, urine, saliva and other body fluids and are considered a novel class of non-invasive biomarkers for various diseases including cancer, neurodegenerative and cardiovascular diseases

objective：to identify the novel circulating mirna expression profiles that may serve as a sensitive and reliable biomarker to predict future adverse cv outcomes and death in patients with established cad. methods：the investigators propose to utilize next-generation sequencing (rnaseq) to identify the novel plasma mirna expression signature linked to adverse cv outcomes in participanrs with cad. the identified mirna candidates that are predictive of adverse cv events will be validated in a larger independent cohort of cad patients. in addition, mirnas that are linked to adverse cv outcomes in cad patients will be investigated mechanistically in human aortic endothelial cells to understand their functional contribution to the occurrence of adverse cv events. what is new or innovative in this study? this study could be one of the few studies to investigate circulating mirnas as novel biomarkers for risk stratification and the clinical outcome prediction in patients with established cad. this report will also demonstrate that some dysregulated circulating mirnas might contribute to endothelial dysfunction and adverse cv events in cad patients. scientific or clinical implication of the expected results：the results from this study will provide a new prognostic tool to predict cv outcomes in cad patients using plasma mirna expression signature. it will also provide important scientific insights into the complex non-coding rna regulatory network involved in the pathogenesis of atherosclerosis. the insights from this study may provide a unique opportunity to improve the risk assessment of adverse cv events in cad patients by targeting theses mirnas.

Eligibility criteria:
inclusion criteria: 1. male or female older than 20 years old. 2. have a history of cardiovascular disease (including coronary heart disease, or peripheral vascular disease) exclusion criteria: significant valvular or congenital heart disease, cancer, immunosuppressive therapy, or other conditions or treatment your physician thinks you have

Keywords: cad mirna
effect of chicken egg antibody (igy) on patients with chronic gastritis

Conditions: Chronic Gastritis Caused by Helicobacter Pylori

Summary: h. pylori positive patient volunteers that passed the selection criteria are recruited and divided into a test and a control group. both groups are treated with a current treatment regime (eac: esomeprazole 40 mg/day; clarithromycin 1000 mg/day; amoxicillin 2000 mg/day) but only the test group received igy-containing food supplement as an adjunctive measure for 15 days. the subjects are examined before and 4 weeks after the treatment initiation by urea breath test (ubt) and gastro-endoscopy.


Eligibility criteria:
inclusion criteria: * patients with gastritis or gastric ulcer who are positive to h. pylori exclusion criteria: * people allergic to egg proteins

Keywords: chronic gastritis gastric ulcer helicobacter pylori igy
observational crossover study comparing oxygenation and ventilation using sipap versus cpap in lbw infants

Conditions: Ventilation; Respiratory Distress Syndrome

Summary: investigation of effects of sipap versus ncpap on oxygenation and ventilation in lbw infants with respiratory distress. our hypothesis is that the lbw infants will achieve the same level of oxygenation and improved ventilation when being treated with sipap as compared to ncpap.


Eligibility criteria:
inclusion criteria: 1. lbw infant (birth weight \<2500 grams) 2. currently on nasal cpap 3. use of nasal cpap for \>24 hours prior to study initiation 4. if history of intubation with mechanical ventilation, patient will be extubated \>24 hours prior to study initiation 5. fio2 requirement of 25-50% exclusion criteria: 1. fio2 requirement \>0.5 2. congenital defects/deformities of the head, pulmonary or cardiovascular systems 3. chromosomal abnormalities/genetic syndromes 4. active medical treatment for symptomatic pda 5. active medical treatment for culture proven sepsis 6. within 24 hours of invasive surgical procedure

Keywords: non-invasive ventilation sipap cpap low birth weight infants respiratory distress syndrome
study of the anti-angiogenesis agent ag-013736 in patients with metastatic thyroid cancer

Conditions: Thyroid Neoplasms

Summary: this is a phase 2 study being conducted at multiple centers in the united states. patients having thyroid cancer that has spread to other parts of the body (i.e., metastatic) are eligible to participate. patients must have disease that was not controlled by previous treatment with radioactive iodine (131i) or not be good candidates for such treatment. the purpose of the study is to test whether the angiogenesis inhibitor ag-013736 is an effective treatment for metastatic thyroid cancer as shown by the number of patients in the study who experience significant and durable tumor shrinkage.


Eligibility criteria:
inclusion criteria: * histologically documented thyroid cancer with metastases. * failure of radioactive iodine (131i) to control the disease or radioactive iodine (131i) is not an appropriate therapy (e.g. due to lack of iodine uptake by the tumor) exclusion criteria: * central lung lesions involving major blood vessels (arteries or veins).(central lesions that maintain the structural integrity of vessels have the potential to bleed if the tumor lesion undergoes necrosis. mri or ct angiography should be used in any case where there is any question as to whether blood vessels are involved.) * patients with a history of hemoptysis
tobramycin 300 mg once-a-day (o.d.) aerosol in adults with cystic fibrosis

Conditions: Cystic Fibrosis

Summary: the study will include 10 adult patients with cystic fibrosis. the aim of the study is to evaluate whether tobramycin 300 mg aerosol once-a-day for 28 days can reduce the bacterial load in the airways. secondary end-point is the evaluation of variation in bacterial susceptibility during and at the end of study period.

ten adult patients with cystic fibrosis will be enrolled in a stable phase and will received prophylaxis with aerosol of tobramycin 300 mg once a day for 28 days.

Eligibility criteria:
inclusion criteria: * outpatients, male and female, age range 18-45 years * diagnosis of cystic fibrosis * fev1 \>50% predicted. * sputum samples available * chest x ray negative for pneumonia and tuberculosis * informed consent exclusion criteria: * allergy to tobramycin * use of systemic steroids in the previous 2 weeks * pregnancy or breast feeding * treatment with other experimental drug in the previous 3 months

Keywords: cystic fibrosis bacterial load inhaled tobramycin
therapeutic equivalence study of hcp0910 250/50 mcg to seretide 250 diskus in asthmatic patients

Conditions: Asthma

Summary: the purpose of this study is to prove that hcp0910 is therapeutically equivalent to seretide 250 diskus when repeatedly dosed to asthmatic patients.


Eligibility criteria:
inclusion criteria: * age 20 \~ 75 inclusive * asthmatic diagnosis in more than 12 weeks from screening day * shows more than 12 % increase, and 200ml increase in fev1 measure on visit 2 exclusion criteria: * maintain controlled asthma for more than 4 weeks before screening * diagnosed as a severe asthmatic patients
hrqol and function of adults treated in adolescence for scoliosis with physical exercises

Conditions: Scoliosis

Summary: we attempt to investigate the influence of physiotherapy and physical activity education applied in adolescence on physical fitness, curve progression, pulmonary function, physical activity and quality of life in adulthood. quality of life assessment includes mental and social functioning, body image, self - esteem, depression and anxiety surveillance. the follow - up period ranges from 15 to 26 years. also a group of shorter follow - up of 9 - 13 years is available. the null hypothesis is that scoliosis specific exercise program applied in adolescence does not influence hrqol and functioning in adulthood.

among conservative treatment approaches of adolescent idiopathic scoliosis (ais), different physiotherapy methods are recommended and popular in some countries (spain, germany, poland), while in others bracing and observation are standard (north america, australia, the uk, scandinavia. neither of the methods have been shown to be definitely effective. considerable evidence indicates that bracing can lead to psychological stress, poorer body image and self - esteem and reduce overall quality of life in adulthood. as to physiotherapy and physical exercises, such evidence is limited, especially long term follow up studies are not available.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of scoliosis in adolescence * participation in exercise program in the centre of compensatory gymnastics in bielsko-biala in adolescence * medical records available exclusion criteria: * contraindications for pulmonary and / or exercise tests * psychiatric disorders * recent trauma * recent traumatic (emotional) event * contraindications for x-ray exposure

Keywords: scoliosis physical therapy long term outcome pulmonary function physical fitness health related quality of life psychopathology
changing technique of abdominal wall closure (phacpa)

Conditions: Closure of Abdominal Wall

Summary: implementing guidelines of ehs for abdominal wall closure in all specialities of a general hospital. migrating from large stitch technique to short stitch technique.

surgeons will receive instruction about new techniques of closure of the abdomen and will practice in models and receive a certification previously to implement in their surgical practice the new technique. results will be monitorised and compared with previous cohort of patients. a protocol of closure will be implemented. patients without risk factors will receive a laparotomy closure with "short stitch" technique and patients with risk factor for developing incisional hernia or burst abdomen and aditional profilactic suprafascial mesh.

Eligibility criteria:
inclusion criteria: * patients operated on by laparotomy exclusion criteria: * previous mesh * concomitant hernia repair

Keywords: abdominal wall closure
a study to evaluate the effect of vitamin d on pfs in indolent non-hodgkin's lymphoma

Conditions: Follicular Lymphoma; Small Lymphocytic Lymphoma; Marginal Zone Lymphoma; Mucosal-Associated Lymphoid Tissue Lymphoma

Summary: despite strong evidence suggesting that vitamin d deficiency is associated with undesirable outcomes in patients with numerous cancers, there has never been a thorough study of vitamin d treatment in subjects undergoing treatment for cancer. the purpose of this study is to evaluate whether modification of vitamin d levels in the blood, through supplementation, can improve outcomes.


Eligibility criteria:
inclusion criteria: each of the following criteria must be met in order for a patient to be considered eligible for registration: * biopsy proven (with hematopathology review at one of the participating sites to confirm correct histology in accordance with world health organization) indolent lymphoma to include the following diagnoses: * grade 1, 2, or 3a follicular lymphoma * small lymphocytic lymphoma (cll excluded) * marginal zone lymphoma (nodal or splenic) * mucosal-associated lymphoid tissue * measurable disease defined by lugano criteria * no prior anti-lymphoma systemic therapy; prior radiation therapy allowed * age 18 or over * ann arbor stages ii, iii or iv * patients with follicular lymphoma must have pet fdg-avid lymphoma and fulfill low tumor burden by groupe d'etude des lymphomes folliculaires (gelf) criteria: * no mass \> 7 cm * \< 3 distinct masses of greater than 3 cm * no b symptoms * no splenomegaly \> 16 cm by computed tomography (ct) scan * no risk of vital organ compression * no leukemic phase \> 5000/µl circulating lymphocytes (except for in patients with splenic marginal zone diagnosis) * no cytopenias (platelets \< 100,000/µl, hemoglobin \< 10 g/dl, or absolute neutrophil count \< 1500/µl) exclusion criteria: the following criteria will prevent inclusion of an inappropriate subject into the trial: * osteoporosis requiring prescription treatment * known symptomatic primary hyperparathyroidism * hypercalcemia defined as above the institutional normal range (corrected for albumin when albumin levels are below normal) * history of calcium-related kidney stones * creatinine \> 1.5x above upper limit of normal * women who are known to be pregnant or who plan to become pregnant while on rituximab treatment
health status and the need for social return of drug abusers in guangdong province

Conditions: Drug Use

Summary: this study intends to conduct a secondary analysis of the data from the investigation on the status quo of anti-drug rehabilitation work and management needs in guangdong province.

the drug problem is a major problem that threatens individuals' physical and mental health, family happiness, national security, regional stability and world peace. in recent years, anti-drug departments in various regions of guangdong province have adhered to the arrangement and deployment of the national anti-drug office, the provincial party committee and the provincial government and the party committee of the public security department, focused on preventing the harm of synthetic drugs, improved the system, implemented responsibilities, and innovated methods, and constantly improved the anti-drug and drug rehabilitation work in guangdong. nowadays, with the improvement of the level of social and economic development, the personnel structure and characteristics of drug abusers in guangdong province have undergone corresponding changes, and the effect of the existing control policies on drug abusers has also shown a weak stage, which needs to be adjusted and updated in time. in this context, guangdong provincial public security department has carried out research on anti-drug management countermeasures, and actively discussed the status quo, difficulties and reform direction of anti-drug management in the new era. this study intends to conduct a secondary analysis based on the data obtained from the investigation and research on the status quo of drug control and detoxification work and management needs in guangdong province, aiming to describe the demographic and sociological characteristics of drug abusers in guangdong province, as well as their psychosocial experience of receiving interpretation intervention and the status quo of social regression needs. what's more, this study also devoted to forming a practical multi-department co-management model of community comprehensive management of drug addicts in guangdong province in the new era, to comprehensively improve the management level of drug abusers in guangdong province, serving grassroots communities, and build a harmonious society.

Eligibility criteria:
inclusion criteria: * cities in guangdong province are selected according to the geographical distribution, development level, economic level and population distribution of the cities. * drug abusers who registered in any of a streets or townships of guangdong province would be selected. * drug abusers who have abstained for more than 3 years. * all age groups under 30 years old, between 30 and 50 years old and over 50 years old were covered. exclusion criteria: * eliminate more than 20 questions missed or not answered questionnaires. * the questionnaires which be filled out by the same respondent repeatedly.

Keywords: drug abuser health condition social regression secondary data analysis
post-op quality of life after colorectal surgery

Conditions: Colorectal Neoplasms; Colitis, Ulcerative; Diverticulitis; Colonic Polyps; Crohn Disease

Summary: the purpose of this study is to produce a user-friendly tool- in the form of a questionnaire - to accurately assess early quality of life in patients after abdominal colorectal surgery from the first day after surgery to 6 months after. the study will also compare this questionnaire to the other currently available assessment tools. patients are invited to participate if they are undergoing abdominal colorectal surgery at university hospitals of cleveland.

the purpose of this study is to produce a user-friendly tool to accurately assess early quality of life in postoperative patients following abdominal colorectal surgery in the early postoperative period (from surgery to 6 months) that is practical for routine application. the study will also compare this tool to the current available tools, namely the short form (sf-36), the short form inflammatory bowel disease questionnaire (ibdq), the cleveland clinic global quality of life (cgqol). patients will be invited to participate if they are undergoing abdominal colorectal surgery at university hospitals of cleveland.

Eligibility criteria:
inclusion criteria: * subjects who are 18 years of age and older * subjects of either sex * subjects who will undergo any colorectal abdominal surgery at university hospitals of cleveland * subjects who agree to participate in the study program and provide written informed consent * diagnoses of crohn's disease, ulcerative colitis, rectal or colon cancer, colon or rectal polyps and diverticulitis exclusion criteria: * patients in the middle of three part surgery or had recent surgery (i.e., back for stoma closure for j-pouch) * patients with diagnosis of rectal prolapse, condyloma or any other condition that cannot be performed abdominally with an open or laparoscopic procedure * patient who have undergone major surgery within the month prior to this colorectal surgery * pregnant women, minors, psychiatric patients and prisoners

Keywords: colorectal surgery abdominal surgery diverticulitis colon cancer rectal cancer colon polyp rectal polyp crohn's disease
the impact of social phone calls on adults who have had a stroke

Conditions: Stroke

Summary: the purpose of this study is to see the impact of social visits, through weekly phone calls, on quality of life and health outcomes of depression, anxiety, loneliness, and self-rated health for adults who have experienced an ischemic or hemorrhagic stroke and to determine the benefit of these conversations on the student volunteer's perspective of adults who have survived a stroke


Eligibility criteria:
inclusion criteria: * have a ucla short form score of 4 or higher * can read, write, and speak english * have had an ischemic or hemorrhagic stroke is the past year * have a telephone and are available for weekly phone calls * provide informed consent agreeing to be contacted by the volunteers exclusion criteria: * reside outside of the home * have electronic health record documentation of aphasia * montreal cognitive assessment score of \<9

Keywords: stroke phone calls social support loneliness ischemic stroke
dynamic gait analysis in children with mucopolysaccharidosis type iva

Conditions: Mucopolysaccharidosis IV; Morquio A Disease

Summary: mucopolysaccharidosis type iva (mps iva, morquio disease) is a rare inherited lysosomal storage disorder caused by deficiency of the enzyme galactose-6-sulfatase. children with this disease accumulate a chemical called keratan sulphate, which stops their skeletons developing properly. they are very short in stature and many of their joints are unstable. children with mps iva walk in a different way to other people due to a combination of lax ligaments and skeletal problems such as knock-knees. human walking involves the coordinated movements of all four limbs. as we walk, the arms swing oppositely to the legs. this movement pattern is very different in children with mps iva. this change seems to involve the whole musculoskeletal system and depends on the severity of the disease. recent studies in children with mps iva describing walking pattern have concentrated solely on the lower or upper limb respectively, and have not looked at the interaction of the upper and lower limbs during walking. to our knowledge, the mechanics of walking in children with mps iva has not been investigated using a dynamic gait analysis tool (using cameras, sensors and electrodes to track the movements of different parts of the body during walking) and we aim to characterise this in a small number of children with mps iva and also examine the effects of splinting the wrist upon the walking pattern to see if this simple intervention makes it easier or more difficult for children with mps iva to walk.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of mps iva (documented history of reduced leucocyte galns enzyme activity relative to the normal range of the laboratory performing the assay and/or molecular analysis showing two pathogenic mutations in the galns gene) * willing and able to provide written assent and parent/legal guardian able to provide written informed consent after the nature of the study has been explained and prior to any research-related procedures * between 6 and 18 years of age inclusive * willing to perform all study procedures as far as physically possible exclusion criteria: * inability to comply with gait analysis protocol (e.g. nonambulant) * recent orthopaedic surgery that investigator deems might impact on gait analysis * use of any investigational product or investigational medical device other than bmn110 within 30 days prior to recruitment, or requirement for any investigational agent other than bmn110 prior to completion of all scheduled study assessments * concurrent disease or condition that would interfere with study participation or safety * any condition that, in the view of the principal or subinvestigators, places the subject at high risk of not completing the study procedures

Keywords: morquio mucopolysaccharidosis galactosamine-6-sulfatase galns