Kornimate/medical-research-clean huggingface dataset:
effects of an exercise program under supervision and unsupervised in the treatment of low back

Conditions: Low Back Pain

Summary: abstract: low back pain is one of the most frequent causes of incapacity. the prevalence of this syndrome is 60-85% for the survival of the individuals. among the most promising strategies of low back pain intervention, is the physical activity that is usually associated with a long list of health benefits.

purpose: evaluate the efficacy of a protocol of exercises to low back pain rehabilitation under supervision of physiatry service and rehabilitation in the hospital de clínicas de porto alegre compared with same protocol performed at home in regards to pain. methods: randomized clinical trial with a sample of 122 subjects of the community of both sex, with ages between 30 to 55, with low back pain complain. these subjects will accomplish during 12 weeks protocol of exercises from "exercises to low back pain" physiatry and rehabilitation service from hcpa, randomized in two groups: group 1 will complete all the protocol of exercises with orientation and attendance directly from a professional of physical education, in the service of physiatry and rehabilitation in hcpa. group 2 will complete one session of the protocol of exercises with orientation and attendance directly from a professional of physical education, in the service of physiatry and rehabilitation of hcpa, to clarify any doubts about the protocol. the further sessions will be completed at home, along weekly monitoring of the researchers through phone calls, the patients of this group will receive a manual with the sequence of the exercises.

Eligibility criteria:
inclusion criteria: * ages between 30 and 55 * pain should be without radiation to lower body * pain with more than 12 weeks of evolution. * visual analog scale of pain (vas) should present a pattern above 3 (moderate). exclusion criteria: * patients with exclusion criteria: will be excluded those patients that present musculoskeletal impairment in lower body, * after surgery and anesthetic block. * individuals affected with comorbidities * patients with rheumatic diseases, recent fractures, tumors, pregnant women, smokers and general practitioners of physical activity. * subjects who are unable to attend the hospital twice a week.

Keywords: low back pain physical exercise and quality of life
trulimax (azithromycin ) non-interventional study in acute bacterial upper respiratory tract infections

Conditions: Upper Respiratory Tract Infections

Summary: to assess effectiveness of trulimax (azithromycin) in acute bacterial upper respiratory tract infections (urtis).

prospective, open-label, non-interventional and multi-center study na

Eligibility criteria:
inclusion criteria: * evidence of a personally signed and dated informed consent document indicating that the subject (or a legally acceptable representative) has been informed of all pertinent aspects of the study. * patients with acute urti, presumed to be of bacterial origin as per the clinical judgment of the investigator. exclusion criteria: n/a

Keywords: trulimax (azithromycin ) non-interventional study
tdcs in post-covid syndrome: comparison of two targets

Conditions: COVID-19; Post-COVID-19 Syndrome; Post COVID-19 Condition

Summary: the main aim of this study is to compare the effect of two non-invasive neuromodulation targets in patients meeting who criteria for the post-covid condition. a randomized, parallel, double-blind study will be conducted. patients will receive 15 neuromodulation sessions through transcranial electrical stimulation for 3 weeks, associated with cognitive stimulation during therapy. the main objective will be to evaluate the change in physical fatigue. as secondary objectives, changes in cognition, depression, pain, quality of sleep and quality of life will be evaluated. the objective of this study is to evaluate the effect of two targets (left dorsolateral prefrontal and m1) of the neuromodulation intervention, together with cognitive stimulation.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of covid-19 at least 6 months before the participation in the study. * diagnosis of post-covid condition according to who criteria. * age 18-65 years. * spanish as native language. * sign of written informed consent. exclusion criteria: * history of stroke * history of traumatic brain injury or central nervous system infection * diagnosis of other neurological or medical disorder that could impact on fatigue. * diagnosis of active psychiatric disorder potentially impacting on fatigue or cognitive function. * chemotherapy or radiotherapy for cancer. * severe sensory deficits (e.g. visual loss) that could limit assessments included int the study protocol. * taking drugs or uncontrolled medical disorder potentially causing or worsening fatigue. specifically, uncontrolled adrenal insufficiency, miastenic syndromes, thyroid disorders, cardiac failure, chronic kidney disorders and neurodegenerative disorders are excluded. * history of abuse of alcohol or other toxics. * any contraindication for transcranial electric stimulation: epilepsy, pregnancy, metallic implants, brain devices, pacemakers, head injuries).

Keywords: post-covid syndrome brain stimulation fatigue cognitive depression transcranial direct current stimulation non-invasive brain stimulation
influence of dalcroze eurhythmics on pains in older women

Conditions: Back Pain; Headache; Leg Pain

Summary: in this study, we attempted to answer the question of whether participation in a 12-week rhythmic exercise program using the dalcroze method affects the level of intensity of pain experienced by women over the age of 65. the level of pain was determined on a numerical scale from 1 to 10 and involved headaches, back pain and leg pain.

background. body pain of various degrees and types can complicate human life. regular physical exercise and good mental health can both have protective effects on the body and its physical health. physical exercises may also, in some aspects, be particularly important for older women who experience varying degrees of headache, back pain, and/or leg pain chronically. the purpose of the study was to analyze the effects of the dalcroze eurhythmic method on headaches, backaches, and leg pains among older women. methods. sixty-two blinded participants with pain were randomized into two groups. women (65 to 82 years old) who had reported the occurrence of headaches, backaches, or leg pains during the 3 months prior to the beginning of the randomized controlled trial study were identified. the participants in the pre-test and post-test used the 0-10 numeric pain rating scale to quantify their pain. women from the experimental group participated for 3 months in the physical exercise program based on the dalcroze eurhythmics method.

Eligibility criteria:
inclusion criteria: * female, 65+ years old, physical and mental state that allows them to participate in the exercise program (ability to follow the instructions), community dwelling exclusion criteria: * taking analgesics indelibly, parkinson's or alzheimer's disease, using social assistance or nursing care.

Keywords: headache elderly women dalcroze eurhythmics back pain leg pain
characterization of medical student burnout using remote physiologic monitoring

Conditions: Wellness; Burnout; Remote Monitoring

Summary: a reliable method for monitoring stress and burnout among medical students is critically needed. to address this gap, our team aims to utilize the cost-effective whoop strap 4.0 wearable device to continuously capture stress-relevant physiologic data (i.e., sleep hours, heart rate variability, respiration rate, resting heart rate) among up to 50 third-year medical students at 24 sidney kimmel medical college at thomas jefferson university for 6 months.

aim 1: to determine whether physiologic metrics of sleep and heart rate variability correlate with subjective assessments of medical student wellness in a 6-month period. hypothesis: less total sleep hours will correlate with higher scores for perceived stress scale-4, medical student well-being index, and patient health questionnaire-9, but lower heart rate variability will correlate with higher scores on perceived stress scale-4, medical student well being index, and patient health questionnaire-9. aim 2: to determine whether physiologic metrics of sleep and heart rate variability correlate with performance on shelf examinations for clinical rotations in a 6-month period. hypothesis: less total sleep hours and lower heart rate variability will correlate with poorer performance on shelf examinations.

Eligibility criteria:
inclusion criteria: * third-year medical student at thomas jefferson university * ≥18 years of age * actively participating in family medicine, internal medicine, neurology, obstetrics/gynecology, pediatrics, psychiatry, surgery, or emergency medicine rotations * own a smart phone for bluetooth pairing with whoop strap 4.0 exclusion criteria: * allergies, contraindications, or unwillingness to wear a wrist device for the study period

Keywords: whoop strap 4.0
covid-19 and rare skin diseases european observational study during an epidemic

Conditions: Rare Diseases

Summary: this is a european observational cohort study (data research) involving multiple centres to look at the potential impact of covid infection on patients with rare skin diseases examining factors such as comorbidity, protection factors, and clinical and/or therapeutic factors. the data collected may provide additional information on the situation of patients and, on a wider basis, provide useful data applicable to the general population.

medical and demographic data will be collected from the medical records of patients. the data required will be specified in appendix 1 (collection form). patients will be identified by their initials (first letter of their surname and first name); the study will last for one year to cover the covid-19 epidemic in france (which includes the areas of mainland france and its overseas departments and territories) and in europe, via the ern-skin european network. the frequency of severe forms of covid-19 will be calculated with a bilateral 95% confidence interval using, as a numerator, the number of patients with a severe form of covid-19 and, as a denominator, the number of patients with a covid-19 diagnosis confirmed by pcr, chest scan, serological assay or by suggestive clinical signs during the medical consultation. a severe form of covid is defined as a case requiring hospitalisation in an intensive care unit, requiring resuscitation, or resulting in death. analysis of the impact of covid-19 infection on rare skin diseases: complications, potential comorbidity factors, impact on the management of chronic conditions (change in treatment) and the experience of patients. the results of the analysis may be compared with those obtained for other groups of diseases. gaining a better understanding of high-risk situations, as well as any aggravation or protective factors, should enable us to issue recommendations adapted to this kind of disease but that may also be useful for the general population. this type of study may also provide "reassurance" to patients with rare diseases who have many questions during this period of epidemic and heightened concern.

Eligibility criteria:
inclusion criteria: * patient with a rare skin disease, * patient of any age (paediatric or adult), * patient with suspected covid-19 infection (remote consultation, face-to-face consultation, general practitioner, hospital physician), * patient in contact with a subject infected with the covid-19 virus, * asymptomatic patient for covid-19 viral infection but with a positive serology, * study information given to the patient and/or to their legal representative, * patient who has been informed and has agreed to this data collection process. exclusion criteria: * patients not suffering from a rare skin disease, * patient and/or their legal representative who object to their participation in the study at the presentation of the information leaflet, * adult patient unable to understand the implications and constraints of the study, * protected adult subject to guardianship or safeguarding measures.

Keywords: skin
diabetes and risk of ischemic stroke.

Conditions: Carotid Stenosis

Summary: diabetes in an independent risk factor for ischemic stroke, whose associated mortality rate is higher and sequelae more serious than for nondiabetics. diabetes increases the risk of stroke or death after surgical carotid revascularization or endoluminal angioplasty. it is, with contralateral ica occlusion, 1 of the 7 factors doubling the stroke risk after carotid endarterectomy. diabetes also enhances the cerebral hemorrhage risk associated with carotid surgery, thrombectomy or thrombolysis revascularization of the cerebral arteries. this study was undertaken to examine whether the hemodynamic cerebral ischemia (hci) frequency, which increases stroke severity, is higher in diabetics than nondiabetics and, if diabetes carries an excess hci risk, whether it is independent of contralateral ica occlusion.

embolic and hemodynamic mechanisms are the main causes underlying ischemic strokes of carotid origin. the hemodynamic cerebral ischemia (hci) risk depends on the contribution of the contralateral internal carotid artery (ica) and vertebral arteries via the circle of willis, the ipsilateral external carotid artery via the ophthalmic artery and the leptomeningeal arteries. during carotid surgery, impaired collateral flow is associated with the need for shunt insertion. when hci is present, cerebral perfusion is initially maintained by vasodilation of precapillary arterioles and the increased extraction coefficient of oxygen. secondarily, vascular reserve exhaustion by degradation of arterial lesions engenders a loss of cerebral autoregulation, ischemic penumbra and cerebral infarction. carotid revascularization with an incomplete circle of willis enhances the postoperative ischemic stroke risk. the loss of cerebral autoregulation, attributable to hci combined with ipsilateral carotid tight stenosis, heightens the risk of hyperperfusion and cerebral hemorrhage. carotid occlusion is the primary cause of hci. carotid occlusions and tight stenoses lead to loss of cerebral autoregulation and cerebrovascular reserve, and have been associated with a 4-fold-increased stroke risk. diabetes in an independent risk factor for ischemic stroke, whose associated mortality rate is higher and sequelae more serious than for nondiabetics. diabetes increases the risk of stroke or death after surgical carotid revascularization or endoluminal angioplasty.it is, with contralateral ica occlusion, 1 of the 7 factors doubling the stroke risk after carotid endarterectomy. diabetes also enhances the cerebral hemorrhage risk associated with carotid surgery, thrombectomy or thrombolysis revascularization of the cerebral arteries. this study was undertaken to examine whether the hci frequency is higher in diabetics than nondiabetics and, if diabetes carries an excess hci risk, whether it is independent of contralateral ica occlusion.

Eligibility criteria:
inclusion criteria: * patients with clamping test during carotid surgery. exclusion criteria: * patients without clamping test during carotid surgery.

Keywords: diabetes ischemic stroke cerebral hemorrhage hypoperfusion hyperperfusion
research to evaluate a possible relation between values obtained after processing ct images, lung function tests and the experience of the patient during an exacerbation in copd patients.

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: in this study the consequences of exacerbations will be visualized by high resolution computed tomography (hrct) scan at functional residual capacity (frc) and total lung capacity (tlc) as taken during an episode of exacerbation and after recovering. changes in hrct based airway dimensions and computational fluid dynamic (cfd) -based resistance values will be correlated with changes in patient reported outcomes (pros) and lung function tests recorded at the same time.


Eligibility criteria:
inclusion criteria: * male or female, ≥ 40 years old * copd as defined by the global initiative on obstructive lung disease4 * post-bronchodilator fev1/fvc \< 70% and post-bronchodilator fev1 \<80%pred as documented in the last 5 years. * smoking history of at least 10 pack-years * at entry in the study experiencing an exacerbation defined as an acute change in the patient 's baseline dyspnea, cough, and/or sputum that is beyond normal day to day variations, and that necessitates the administration or doubling of systemic corticosteroid treatment. * patients must be able to understand and complete protocol requirements, instructions, questionnaires and protocol-stated restrictions. * written and signed informed consent exclusion criteria: * pregnant or lactating females * patient diagnosed with asthma * patient with pneumonia as defined radiologically at the start of the exacerbation * patient with a history of or presence of lung cancer * patient with an indication for non-invasive ventilation * patient unlikely to comply with the protocol or unable to understand the nature, scope and possible consequences of the study. * patient who received any investigational new drug within the last 4 weeks prior to visit 1.

Keywords: pulmonary disease, chronic obstructive copd exacerbation functional respiratory imaging high resolution computed tomography hrct scan patient reported outcome pro computational fluid dynamic cfd lung function parameters
anti-programmed cell death-1 ligand 1 (apdl-1) antibody atezolizumab, bevacizumab and acetylsalicylic acid in recurrent platinum resistant ovarian cancer

Conditions: Ovarian Neoplasms

Summary: this is a randomized phase ii study, aimed at evaluating the efficacy (through progression free survival at 6 months) and safety of 5 different treatments involving atezolizumab, bevacizumab and/or acetylsalicylic acid in advanced recurrent platinum-resistant ovarian cancer patients in order to select the optimal treatments for further development in phase iii.


Eligibility criteria:
inclusion criteria: recurrent, histologically proven, platinum-resistant, epithelial ovarian, fallopian tube and primary peritoneal cancer in advanced or metastatic stage. histological diagnosis by image guided biopsy, laparoscopy or laparotomy. tumors diagnosed on cytology only and borderline tumors are excluded. at least one lesion accessible to biopsy without putting patient at risk who ps: 0-2 for patients having received no more than two previous lines of therapy. who ps: 0-1 for patients having received \>2 previous lines of therapy prior chemotherapy or bevacizumab: any number of platinum-based chemotherapy lines are allowed but a maximum of 2 previous non-platinum containing lines prior treatment with bevacizumab or other targeted agents against vascular endothelial growth factor (vegf) or vegf receptor is allowed, but at least 18 weeks must have elapsed since their last administration eligible patients with ≤ 2 previous treatment lines must have been previously exposed to bevacizumab or other targeted agents against vegf or vegf receptor patients may have had prior therapy providing the following conditions are met: radiation therapy: wash-out period of 14 days prior to the first study treatment; exception: single fraction radiotherapy with the indication of pain control systemic anti-tumor therapy: wash-out period of 21 days prior to the first study treatment recovery from any toxic effects of prior therapy to ≤ grade 1 per the national cancer institute common terminology criteria for adverse events (nci ctcae v4.03) except fatigue or alopecia. exclusion criteria: age \<18 years life expectancy of \< 12 weeks no adequate hematologic and end organ function use of acetylsalicylic acid, nsaids or other cox-2 inhibitors that cannot be stopped at baseline and for the whole duration of the study.
effects of 3d-printed on lower extremity biomechanics in individuals with knee osteoarthritis

Conditions: Medial Knee Osteoarthritis

Summary: the purposes of this study are: (1) to determine the kinematics, kinetics, and muscle co-activation ratio of level walking and stair negotiation under three different conditions (shoes only, shoes embedded 3d printed insoles, and shoes embedded 5-degree lateral wedges), (2) to build a detailed patient-specific knee model via mr images and musculoskeletal model, then, evaluate the compressive forces acting on the medial aspect of the knee during level walking and stair negotiation.

this study is a cross-sectional study with patients serving as their own control. the investigators will recruit 20 patients with knee osteoarthritis. using motion capture system, force plates, wireless emg to capture the motion data of patients during walking and stair negotiation in each condition.

Eligibility criteria:
inclusion criteria: * medial knee oa (kellgren-lawrence grade i, ii or iii) according to clinical and radiological criteria of the american college of rheumatology * aged from 50 to 70 years exclusion criteria: * neuromuscular illness (e.g., parkinson disease, neuropathy) * predominant lateral or patella-femoral oa * previous of planned hip or knee replacement * hip or ankle arthritis * rheumatoid arthritis * unable to walk without a cane or walker * unable to walk up and down the stairs
grape juice and dermatitis in breast cancer

Conditions: Breast Cancer

Summary: this study aimed to investigate the effect of grape juice on acute radiation dermatitis in breast cancer (bc) patients undergoing radiotherapy (rt). 50 eligible bc patients will randomly assign to consume 100 gr of grape juice per day during and 1 week after rt or with no intervention (control group). the radiation dermatitis will be assessed weekly according to the radiation therapy oncology group/ european organization for research and treatment of cancer (rtog/eortc) scales.

dietary intake of patients will be examined by expert dietitians at baseline and end of rt using the average of three-day 24-hour recalls. weight (kg), body fat percentage, skeletal muscle percentage and visceral fat level will be measured using the omron body composition monitor and scale.

Eligibility criteria:
inclusion criteria: * women with brest cancer undergoing adjutant radiation therapy exclusion criteria: * previous history of rt, mrm, * concomitant presence of two or more malignant tumors * metastasis to other areas * allergy or intolerance to tahini * skin diseases and wounds * severe liver and renal disease * autoimmune diseases * pregnant and lactating women * those who treated with hypo fraction rt