Kornimate/medical-research-clean huggingface dataset:
sedative premedication: efficacy on patient experience

Conditions: Perioperative Anxiety

Summary: seven french university hospitals will participate in this multicentric prospective, blinded and randomized study. the investigators designed 3 study groups: lorazepam 2.5mg, placebo (microcrystalline celluloses) and no premedication at all. the third group (no premedication) is necessary in order to evaluate a placebo response, which may be significant on anxiety level and patients perceptions of care. it was calculated that 969 patients had to be included in order to obtain a 5 point difference between groups on the evan score with 80 % statistical power, leading to the inclusion of 1200 patients with an estimated maximum dropout rate of 15 %. all adults below 70 years and scheduled for elective surgery under general anesthesia can be included after information by an anesthesiologist in charge of the study and written informed consent. non inclusion criterions are: a weight below 45 kg, a counter indication to benzodiazepine, surgeries that could impair cognitive functions (cardiac or neurologic surgery), usual use of neuroleptics or lithium, drug addiction or former cognitive disease. the technique of anesthesia will be decided by the attending anesthesiologist, who will be unaware of the premedication technique, independently of the study protocol.


Eligibility criteria:
inclusion criteria: * male or female aged 18 to 70 years or more; * about a weight greater than 45 kg; * subject to benefit from a scheduled surgery under general anesthesia; * topic respecting the ambivalence clause defined below: 1. having no cons-indication to the use of benzodiazepines; 2. having no known allergy to benzodiazepines; 3. may be a candidate for the prescription of premedication; * topic able to complete a self-administered questionnaire; * subject has signed a written informed consent and agreeing to abide by the instructions of the protocol exclusion criteria: * - topic of over 70 years; * topic 45 kg or less; * topic demanding to receive anxiolytic premedication; * subject severe respiratory insufficiency; * topic minor, pregnant or breastfeeding, about not being affiliated to the social security system; * topic for which surgery is performed under local anesthesia; * subject unable to perform only a self-administered questionnaire (inability to read french, severe cognitive impairment); * subject to which the scheduled surgery may cause postoperative cognitive dysfunction (intracranial surgery, extracorporeal circulation); * topic scheduled for obstetrical surgery or outpatient; * subject treated with antipsychotic (neuroleptic or lithium); * subject with cognitive impairment already documented (alzheimer, dementia, neurological sequelae); * subject active consumer of narcotics; * subject has not signed informed consent.
a brief alcohol intervention for incarcerated women

Conditions: Alcohol Use; Incarceration

Summary: the purpose of this study is to examine the efficacy of a brief motivational intervention for alcohol use in incarcerated women.

hazardous alcohol use continues to be a problem of major significance throughout the united states. alcohol use is a prevalent condition that independently acts as an important behavioral cofactor for hiv infection in women, contributing to both sexual and drug risk. the rationale for a brief intervention with incarcerated women who hazardously use alcohol and have hiv risk behaviors is compelling. for such women, we believe that the negative effects of drinking may be increased. an intervention that successfully connects alcohol use with hiv risk behaviors may be sufficient to tip the decisional balance in favor of reducing risk-prone alcohol consumption. if alcohol consumption is reduced more generally in a person's life, this may improve judgment in pursuing behaviors which risk other negative consequences. hazardous alcohol, and high-risk drug and sexual activities may be manifestations of a general behavior pattern among incarcerated women, and strategies that engage such individuals are needed. given the strong association between hazardous alcohol use and high hiv risk sexual and drug activities, interventions that attempt to lower the prevalence of hiv drug and sexual risk activities by lowering alcohol consumption are well justified. brief alcohol interventions have been efficacious in reducing alcohol use across many populations over the past decade. comparison(s): participants are assigned, in this 6 month study, to an assessment-only condition or an assessment plus motivational interview condition. two motivational interview sessions are conducted during the first month of study participation.

Eligibility criteria:
inclusion criteria: * incarcerated women * current hazardous drinking * current hiv risk behavior exclusion criteria: -

Keywords: women incarceration alcohol use motivational interviewing
the safety outcomes of 27 gauge vitrectomy for posterior segment disease in high myopia

Conditions: Wound Complication; High Myopia; Vitrectomy

Summary: in recent decade, a major improvement in vitreoretinal surgery was the use of small gauge surgical systems that improved the safety of vitrectomy and also reduced the surgical time. however, there were still some concerns regarding small gauge vitrectomy system, especially 27-gauge system, in the stability of its instruments and the efficacy of removing vitreous during surgery. although there were some studies that had reported the surgical outcomes of 27g vitrectomy system, none had focused on patients with high myopia. the highly myopic patients usually had thinner sclera, which was a risk factor for wound leakage after sutureless vitrectomy, they also had longer axial length which would make the surgical procedure more difficult especially in macular surgery. based on previous clinical finding, gas leakage was 36.4% in 25g , while 27g sclerotomy showing less leakage comparing to larger gauge sclerotomy, the investigators believe 27g may have its clinical advantages in overcoming the thinner sclera of high myopia, and show the superiority of leakage control. hypothesis: the 27g vitrectomy system has lower sclerotomy wound leakage rate compared with 25g system


Eligibility criteria:
inclusion criteria: 1. highly myopic patients (axial length 26\~31mm) 2. diagnosed with vitreoretinal pathology that require vitrectomy 3. never received vitrectomy before exclusion criteria: 1. surgical planning including scleral buckling during operation 2. surgical planning including combined phacoemulsification 3. surgical planning including the use of silicone oil and/or perfluorocarbon liquid 4. previous ocular surgery involving conjunctival manipulation and scarring such as pterygium removal/trabeculectomy 5. previous vitrectomy 6. previous ocular trauma involving corneal/corneoscleral/scleral/conjunctival full thickness laceration 7. medical history with known connective tissue disease(s) 8. age younger than 20 years old

Keywords: vitrectomy high myopia wound leakage
polyamine-low diet to prevent postoperative pain after cholecystectomy

Conditions: Surgery

Summary: it has been shown that n-methyl-d-aspartate (nmda) receptor antagonists (such as ketamine) potentiate analgesic drug's efficacy. polyamines are allosteric modulators of nmda receptors. in animal studies, polyamine-free diet has shown antinociceptive properties. this research aims at evaluating analgesic properties of polyamine-low diet after laparoscopic cholecystectomy performed in an ambulatory setting.


Eligibility criteria:
inclusion criteria: * laparoscopic cholecystectomy * ambulatory surgery * agreeing to follow a polyamine-low diet with polydol plus exclusion criteria: * pregnancy * contra-indication to a non-steroidal anti-inflammatory, to tramadol * intolerance to cow proteins * diabetic patients * poor understanding of the french language.

Keywords: pain polyamine cholecystectomy
the effect of hot water application in pregnant women with restless legs syndrome: a randomised controlled study

Conditions: Restless Legs Syndrome; Pregnancy Related

Summary: backgraund and purpose: the prevalance of restless legs syndrome (rls) in pregnants varies between 15.4-26.0 percent. as well as pharmacological methods, there are studies reporting that non-pharmacological methods reduce rls symptoms but the number of studies conducted with pregnants is limited. this study was conducted to determine the effect of hot water application to the legs of pregnants with rls on their complaints. materials and methods: the study is a pretest-posttest randomised controlled. among the pregnants whose irls score was more than 11, 13 people to the intervention group and 16 people to the control group were randomised. the data were collected using personal information form, international rls study group diagnostic criteria, and the international rls rating scale (irls). hot water application was made of intervention group. the application was made for 20 minutes before bedtime for seven days. no application was made in the control group other than routine care and follow-up. chi-square test, descriptive statistics and dependent/independent samples t tests were used to assess the data. the value of p\<0.05 was accepted as significant.


Eligibility criteria:
inclusion criteria: * in the gestation age of 28-32 weeks, * literate, * according to rls diagnostic criteria and had 11 and higher severity according to international rls rating scale (irls) exclusion criteria: * risky pregnancies, * communication problems, * any chronic and psychiatric disease * were using antipsychotic, antidepressant, antihistaminic, and antiemetic drugs, * had history of deep vein thrombosis

Keywords: restless legs syndrome pregnancy hot water application nursing
the identification of optimal ultrasonografic tecniques for determining the location , size and the surgical methods of intestinal endometriotric nodules

Conditions: ULTRASONOGRAPHY; Endometriosis, Rectum

Summary: the identification of optimal ultrasonografic tecniques for determining the location , size and the surgical methods of intestinal endometriotric nodules

nulliparous patients who had diagnosed with endometriosis ( endometrioma and/or deep endometriosis) without additional gynecological patology applying for routine gynecological check-up to zeynep kamil training and research hospital, gnecology and obstetrics clinic between march 2020 and march 2021 will be included in the study.inclusion criteria in the study. inclusion criterias are the presence of endometrioma and/or endometriosis diagnosed with ultrasonographic evaluation, nulliparity,no additional gynecological patology such as myoma uteri, polype, a history of pelvic inflammatuar disease, a history of cervical or uterine surgery, uterine anomalies as well as patients in the control group will be nulliparous and have no gynecological patology including endometrioma and/or endometriosis.all patients will be evaluated in the follicular phase.with the ultrasonographic examination, the uterine version ( anteversion or retroversion) will be evaluated, the length of the uterus (from fundus to cervix on the saggital axis), the anterior-posterior widest uterin length ( at the level of corpus uteri), the cervical length (the distance between the internal os and external os), the cervical anteroposterior length ath the internal os level and the servical canal length at the internal os level, uterocervical angle (the angle between the longitudinal axis of the cervix and the longitudinal axis of the uterine body will be measured three times consecutively , the avarage of the three measurements will be recoreded).with the 90 degree rotation of the probe at the transverse axis the width of the widest corpus level of uterus and the width of the cervix will be measured.measurements will be made by the same clinician with the same ultrasound device. these measurements and the patients' age, bmi(body mass index), menarche cycle duration, dysmenorrhea, dyspareunia, family history in terms of endometriosis, endometrisosis stage will be recorded.

Eligibility criteria:
inclusion criteria: * diagnosed with deep infiltrative endometriosis and intestinal involvement * treatment will be done surgically * patients should be nonvirgin exclusion criteria: * patient has one or more extra -intestinal findings of deep infiltrative endometiosis

Keywords: endometriosis diagnostic imaging
prediction of the spontaneous breathing test success using biosignal and biomarker in critical care unit by a machine learning approach

Conditions: Weaning From Mechanical Ventilation in Care Unit

Summary: context: several authors have been interested in applying artificial intelligence (ai) to medicine, using various machine learning (ml) techniques: managing septic shock, predicting renal failure... \[1, 2\] ai has an important place in decision support for clinicians \[3\]. the weaning period is a really important time in the management of a patient on mechanical ventilation and can take up to half of the time spent in intensive care unit. the first weaning attempt is unsuccessful in 20% of patients however, mortality can be as high as 38% in patients with the most difficult weaning \[4\]. only a few studies have looked at the application of machine learning in this area, and only one has looked at the use of biosignals (cardiac rate, ecg, ventilatory parameters...) \[5-7\]. to improve morbidity, mortality and reduce length of stay, it is essential to be able to predict the success of the spontaneous breathing test and extubation. investigators propose to develop a predictive algorithm for the success of a ventilatory weaning test based on biosignal records and others features. methods: it is a critical care, oligo-centric and retrospective study the investigators included biosignal variables extracted from the electronic medical record, such as respiratory (rr, minute volume...), cardiac (systolic pressure, heart rate...), ventilator parameters and other discrete variables (age, comorbidity...). most biosignal variables are minute-by-minute records. recording starts 48 hours before the test and stops at the start of the weaning test. the investigators extracted features from these records, combined them with other biomarkers, and applied several machine learning algorithms: logistic regression, random forest classifier, support vector classifier (svc), xgboost, and light gradient boosting method (lgbm)...


Eligibility criteria:
inclusion criteria: * computerized health report (chr) * spontaneous breathing test should have been performed exclusion criteria: * spontaneous breathing test has not been performed, * biosignal (cardiac, respiratory) are not registered in the chr * patient died before the spontaneous breathing test * opposition to the study has been expressed.
treatment research investigating depression effects on neuroimmune targets (trident)

Conditions: Depression; HIV-1-infection; Inflammation

Summary: the purpose of this randomized controlled trial is to understand how a cognitive-behavioral treatment (a form of psychological treatment) for depression changes the gut microbiome (micro-organisms that regulate the health of the gut), immune system, and the brain functioning in people living with hiv.

the overarching goal of this randomized controlled trial (rct) is to identify the causal pathways that drive depressive symptoms among people with hiv (pwh). the scientific premise is that evidence-based depression treatment is an innovative, experimental probe to determine the neural substrates of depression and mechanistic relevance of microbiome-gut-brain (mgb) axis changes during and after cognitive-behavioral therapy for adherence and depression (cbt-ad) on brain and behavioral function. the proposed causal pathway is that reductions in depressive symptoms following the delivery of cbt-ad treatment will trigger a cascade of alterations in the mgb axis. specifically, cbt-ad related decreases in depressive symptoms will induce alterations in gut dysbiosis, decrease microbial translocation, and improve soluble neuroactive markers of peripheral immune dysregulation. our efforts to elucidate the immunologic mechanisms whereby cbt-ad could improve neurobehavioral outcomes will also focus on an established leukocyte signaling pathway, the conserved transcriptional response to adversity (ctra), which has been shown to be responsive to behavioral interventions and psychosocial factors outside of hiv.

Eligibility criteria:
inclusion criteria: 1. age 18 or older 2. speaks and reads english 3. verified hiv+ status with antiretroviral medications bearing his/her name 4. current diagnosis on major depressive disorder (mdd) using a structured clinical interview (diamond) or hamilton rating scale for depression scores of 7 or greater 5. if prescribed antidepressants, on a stable regimen and dose for at least 2 months 6. suppressed hiv viral load (\< 200 copies/ml) 7. able to complete functional magnetic resonance imaging (fmri) scans (i.e., no claustrophobia, no metal implants, no pacemaker, and bmi \< 40) exclusion criteria: 1. unable to provide informed consent 2. active, untreated major mental illness 3. pregnancy at baseline 4. received cbt for depression in the past 2 years 5. otherwise eligible but does not complete baseline biospecimen collection and fmri visit

Keywords: depression microbiome hiv cbt-ad gut brain
side effects of anti-pd-(l)-1 and anti ctla-a4 in the non small cells lung cancer

Conditions: Carcinoma, Non-Small-Cell Lung; Drug-Related Side Effects and Adverse Reactions

Summary: the immune-related adverse events (iraes) linked to the important activation of the immune system by new immunotherapy treatments in patients affected by non-small-cell lung carcinoma (nsclc) have not received a lot of systematic study or been monitored over time outside of clinical trials. this study aims to verify, on the basis of the data collected in a prospective and retrospective manner, that the side-effects due of anti-pd-(l)-1 or anti-ctla-4 treatments observed in the target population of the controlled clinical trials are the same as in the general clinical population.


Eligibility criteria:
inclusion criteria: * any patient with nsclc treated in cliniques universitaires saint-luc with immunotherapy in first or second line. exclusion criteria: * the refusal to sign the consent.

Keywords: immunotherapy anti-pd-(l)-1 anti-ctla-4
corev 2.0 pmcf-study on manual and navigated revision knee patients

Conditions: Knee Osteoarthritis; Bone; Deformity, Congenital; Prosthesis Failure; Prosthesis-Related Infections

Summary: the columbus® revision endoprosthetic system is bearing the ce-mark. this means that within the scope of this observational study the patient will not be subjected to any additional stressful, study-related medical examinations or treatment measures. the treatment will be carried out exclusively according to medical standards. the study therefore only serves the purpose of observing this standard-compliant treatment and specifically documenting it scientifically.

the study's main purpose is the collection of clinical data on the safety and performance of the columbus® revision knee endoprosthesis

Eligibility criteria:
inclusion criteria: * patient underwent navigated revision surgery using the columbus® revision knee prosthesis (case group) * patient underwent conventional manual revision surgery using another implant system (control group) * written informed consent exclusion criteria: * pregnancy * patient age at time of revision surgery \< 18 years * allergy to any prosthesis component

Keywords: computer assisted surgery revision total knee arthroplasty joint alignment observational study forgotten joint score
insulin-like growth factor (igf-i) in hemodialysis patients

Conditions: Kidney Failure, Chronic

Summary: the purpose of this study is to investigate whether the anabolic potentials of insulin may be used to reverse the catabolic effects of hemodialysis in non-diabetic patients with end-stage renal failure.

nutritional markers such as lean body mass and serum albumin are strong predictors of the mortality and morbidity in patients with end-stage renal failure (esrf) on maintenance hemodialysis (hd). maintenance hd is considered to contribute to the malnutrition of patients with esrf, but the exact mechanism has remained unknown. however, we have recently shown that the bioactivity of insulin-like growth factor-i (igf-i) is reduced by 50% during hd. furthermore, we showed that the reduction in the bioactivity of igf-i is directly linked to an up-regulation of igf-binding protein-1 (igfbp-1), the only acutely regulated igfbp, which increased by 6-fold during hd. igfbp-1 is produced in the liver, primarily under the control of insulin, which promptly inhibits the hepatic production of igfbp-1. as plasma insulin remains fairly low during a maintenance hd, the increase in igfbp-1 may be explained by the absence of insulin. the finding that hd acutely down-regulates the bioactivity of igf-i by an up-regulation of igfbp-1 may not only explain the catabolic mechanisms of hd per se, it also opens for a new treatment strategy of esrf patients undergoing maintenance hd. thus, on the basis of our previous study we hypothesize that treatment of ersf patients with high doses of insulin during maintenance hd may counter-act the hd-induced stimulation of igfbp-1, making it possible to preserve the bioactivity of igf-i, and thereby abolishing the catabolic impact of hd.

Eligibility criteria:
inclusion criteria: * \> 18 years * stable patients on maintenance hemodialysis for \> 3 months * well-functioning arteriovenous (av) shunt with recirculation \< 5% * informed consent exclusion criteria: * diabetes mellitus * body mass index \ 30 kg/m2 * malnutrition (subjective global assessment (sga) score c) * malignancy * use of immunosuppressive drugs including glucocorticosteroids * severe infectious disease \< 4 weeks * pregnancy exclusion criteria during the study: * myocardial infarction or arrythmia with hemodynamic derangements * permanent thrombosis in the arteriovenous (av) shunt * severe infectious disease * renal transplantation

Keywords: dialysis malnutrition insulin-like growth factor i insulin-like growth factor binding protein 1 inflammation