Kornimate/medical-research-clean huggingface dataset:
effect of aromatherapy on pain, anxiety and sleep quality in burn patients

Conditions: Aromatherapy

Summary: this study, which was designed as a randomized placebo-controlled experimental study, was conducted to determine the effect of inhalation aromatherapy with lavender essential oil on pain, anxiety and sleep quality in burn patients.

after 5 patients were included in the sample size of the study, intervention and control groups, power analysis was performed using the g\*power software (3.1.9.2) program. with a margin of error of 5%, an effect size of 0.15, and a power of 95%, the sample group size was calculated as 54 patients. considering that data loss might be 10% on average in the study, it was decided to recruit 60 patients. participants were randomized according to patient rooms. there are a total of 11 rooms and 16 beds in the burn unit, 5 double and 6 single. 11 rooms are numbered sequentially according to their location in the corridor. in the intervention group, seven drops of lavender essential oil were dripped onto a 5x5 gauze pad in the morning and evening, for 20 minutes, 10 cm away from the nose, and sniffed. in the placebo control group, seven drops of saline/sterile water were dripped onto a 5x5 gauze pad in the morning and evening, and they were put to sniff for 20 minutes, 10 cm away from the nose. green food coloring was added (one drop of food coloring to 5 ml of sterile/saline water) to make sterile/saline water similar to lavender oil. data were collected using individual data collection form, spielberg state anxiety scale, visual analog scale, richard campbell sleep scale before and after five days of morning and evening aromatherapy application.

Eligibility criteria:
inclusion criteria: * between the ages of 18-65, * 2nd and/or 3rd degree burns but not in emergency/resuscitative phase, * total body burn area is 5-30%, * no acute-chronic respiratory system disease (asthma, copd, etc.), * no problem in sense of smell, * no communication problem, * not participating in another study at the same time, * patients who volunteered to participate in the study. exclusion criteria: * those who are allergic to lavender essential oil, * having a history of head trauma or convulsions, * having respiratory tract (inhalation) burn, * having alcohol or narcotic substance addiction, * having a history of pregnancy, epilepsy, high blood pressure and migraine, * patients undergoing intubation.

Keywords: burn anxiety lavender aromatherapy nursing pain sleep quality
promoting altruism to enhance vaccine acceptance

Conditions: Vaccine Refusal

Summary: subjects enrolled in this study are eligible for the seasonal influenza vaccine. the purpose of this research study is to figure out if increasing individuals' awareness of the benefits of herd immunity, specifically to the local pediatric oncology community, can improve vaccination uptake rates.

the purpose of this study is to identify associations with influenza vaccine hesitancy, including parental demographics and altruism score, in families with healthy children attending two pediatric practices. also, in the cohort of families with baseline vaccine hesitancy, to assess the effectiveness of a pilot educational intervention focusing on the development of herd immunity for pediatric oncology patients by measuring: 1. the change in vaccine hesitancy scores pre- and post-intervention. 2. the rate of influenza vaccine uptake compared to historic controls from previous influenza seasons. another aim is to explore the relationship between baseline influenza vaccine hesitancy rates and baseline altruism scores. effectiveness of this intervention is dependent on parental altruism levels; therefore, the study team also seeks to determine if there is an association between parental altruism and vaccine hesitancy for their children. this is a single-arm prospective cohort study. the study will enroll legal guardians of children who are influenza vaccine-eligible to measure their vaccine hesitancy scores, altruism scores, and the impact of an educational intervention focused on herd immunity on the guardians' vaccine hesitancy score.

Eligibility criteria:
inclusion criteria: * all legal guardians of children aged 6 months and up who are influenza vaccine-eligible and present to the pediatric clinic. exclusion criteria: * legal guardians of children who are not influenza vaccine-eligible including children less than 6 months of age, children on immunosuppressive medications, and children with underlying medical conditions resulting in an immunocompromised state.

Keywords: altruism vaccine acceptance flu vaccine
tahiti-families: polynesian families of gout patients

Conditions: Gout

Summary: gout is a chronic disease caused by the deposit of monosodium urate (msu) crystals in body tissues secondary to hyperuricemia. patients with gout suffer severe attacks of acute joint pain. as the disease progresses, the joint pain becomes chronic and associated with disabling and deformative manifestations called tophus. this disease is strongly associated with several comorbidities such as cardiovascular disease and chronic kidney failure. gout is a very common disease, which is affecting 0.9% of the adult population in france and nearly 4% of the north-american population. data from new zealand show a particularly high prevalence of gout among polynesians (minority populations in new zealand and other islands of the south pacific) that would be explained by genetic susceptibility and frequently interrelated metabolic diseases. data on the polynesian population in new caledonia suggest prevalence figures close to 7% and prevalence in french polynesia is assumed to be higher. international genomic studies of gout and hyperuricaemia have identified alleles associated with the occurrence of gout. the aim is to focus on families with several gouty members (numerous in french polynesia, and geographically clustered) in order to enable the study of individuals with monogenic gout or with a low number of variants (= cases) determining in the occurrence of gout, as well as a non-gouty family member (= controls). dual-energy ct scan (dect) allows identification and quantification of ums crystal deposits in the tissue. the volume of crystals correlates not only with the inflammatory activity of the disease but also with the comorbidities that complicate it. dual-energy scanning has shown the presence of ums crystals in some hyperuricemic individuals, which could help to identify those individuals most at risk of developing the disease as they already have the stigma of sub-clinical inflammatory activity.


Eligibility criteria:
inclusion criteria : case group : * gout patients * polynesian origin * aged 18 to 80 years * agreeing to participate in the study * having a 1st or 2nd degree relative who is also gouty and a 1st degree relative of the same generation and sex who is not gouty control group : * non-gouty individuals who are 1st degree relatives of a gouty patient of the same generation and sex * aged 18 to 80 years * agreeing to participate in the study exclusion criteria : * pregnant women * persons under guardianship, curatorship or other legal incapacity * persons with a contraindication to magnetic resonance imaging (mri) examination * for non-gouty controls : current hyperuricemic treatment (allopurinol, febuxostat, probenecid or benzbromarone) * for gouty case : not participating in the topata study (nct04812886)

Keywords: gout french polynesia epidemiology family
the effect of stevia rebaudiana extracts on different variables related to caries: an in vitro and in vivo evaluation.

Conditions: Dental Caries

Summary: the aim of the present investigation was to evaluate the effect of stevioside and rebaudioside on several variables related to caries development. two approaches were performed: an in vitro evaluation of the growth of a culture of mutans streptococci and in vivo randomized study on the effect of a single rinse containing stevioside and rebaudioside on plaque-ph.


Eligibility criteria:
inclusion criteria: good general health, normal salivary secretion rate, normal buffer capacity exclusion criteria: systemic diseases, salivary secretion reduction, reduced buffer capacity

Keywords: dental caries stevioside rebaudioside plaque ph streptococcus mutans
dosing validation study of oral testosterone undecanoate (tu, lpcn 1021).

Conditions: Hypogonadism, Male

Summary: multicenter, open-label, one treatment study evaluating the efficacy of lpcn 1021 in adult hypogonadal male subjects.


Eligibility criteria:
inclusion criteria: 1. serum total t below 300 ng/dl based on 2 consecutive blood samples obtained between 6 and 10 am, on two separate days at approximately the same time of day, following an appropriate washout of current androgen replacement therapy. 2. subjects should be diagnosed to be primary (congenital or acquired) or secondary hypogonadal (congenital or acquired). 3. naïve to androgen replacement or has discontinued current treatment and completed adequate washout of prior androgen therapy. washout must be completed prior to collection of baseline serum t samples to determine study eligibility. exclusion criteria: 1. history of significant sensitivity or allergy to androgens, or product excipients. 2. clinically significant findings in the pre-study examinations including abnormal breast examination requiring follow-up. 3. abnormal prostate digital rectal examination (dre) with palpable nodule(s). 4. subjects with symptoms of moderate to severe benign prostatic hyperplasia. 5. clinically significant abnormal laboratory value, in the opinion of the investigator, in serum chemistry, hematology, or urinalysis 6. positive test result for hepatitis a virus immunoglobulin m (hav-igm), hepatitis b surface antigen (hbsag) or hepatitis c virus antibody (hcv ab) or human immunodeficiency virus antibodies (hiv ab). 7. history of gastric surgery, cholecystectomy, vagotomy, bowel resection or any surgical procedure that might interfere with gastrointestinal motility, ph or absorption. 8. history of any clinically significant illness, infection, or surgical procedure within 1 month prior to study drug administration. 9. history of stroke or myocardial infarction within the past 5 years. 10. history of or current or suspected prostate or breast cancer. 11. history of untreated and severe obstructive sleep apnea. 12. history of long qt syndrome (qtc \> 450) or unexplained sudden death in a first degree relative (parent, sibling, or child).
effect of abdominal hypopressive training on stress urinary incontinence

Conditions: Female Stress Urinary Incontinence

Summary: fifty female athletes suffering from stress incontinence (sui) will participate in this study. they will be selected from el zohour club, new cairo city.

they will be randomly distributed into 2 groups equal in numbers: group (a) (control group) consists of 25 female athletes. they will receive nutritional instructions and pelvic floor muscle exercises three sessions/week for 3 months. group (b) (study group) consists of 25 female athletes. they will receive the same treatment for the control group and abdominal hypopressive exercises three sessions/week of 30 mins per week for 3 months. before data collection, the purpose and procedures will be fully explained to the females. informed consent will be obtained from each female. each female will be evaluated following a standard protocol.

Eligibility criteria:
inclusion criteria: 1. female athletes suffering from sui. 2. they will be diagnosed with sui using bladder stress test. 3. their ages will range from 14-18 years old. 4. their body mass index (bmi) will range from 18.5-24.9 kg/m2. 5. they are single females. exclusion criteria: the female athlete will be excluded if they had: 1. urinary tract infection. 2. family history of genito-urinary tract cancer. 3. diabetes mellitus.

Keywords: stress incontinence, and female athelete
cascade genetic testing of familial hypercholesterolemia

Conditions: Familial Hypercholesterolemia

Summary: familial hypercholesterolemia (fh) is a frequent genetic disorder (1/200) associated with an increased risk of early-onset myocardial infarction. to improve detection and treatment of patient with fh, cascade genetic testing in families is recommended by many cardiovascular prevention guidelines. however, the implementation of national genetic cascade screening is challenging, because legal protection to guarantee privacy of data do not authorize physicians to directly contact at-risk relatives. using current mobile information technologies and a centralized web-based platform, we designed an ethical genetic cascade screening program for fh to be tested in switzerland.


Eligibility criteria:
inclusion criteria: * patients with severe hypercholesterolemia and familial or personal history of early-onset cardiovascular disease = dutch lipid clinic network score (dlnc) \>= 6 points. exclusion criteria: * patients without at least one contactable first-degree family members
the imagekids study: developing the pmedic and the picmi

Conditions: Crohn's Disease

Summary: the overall objectives of this study are to develop two indices capable of measuring intestinal damage, and, separately, inflammatory disease activity in pediatric crohn's disease by means of magnetic resonance imaging with enterography protocol (mre) and pelvic mri.

the picmi score and the pmedic are aimed to be discriminative (at one point in time), evaluative (measuring damage progression over time) and predictive. the indices will be used as endpoint measures in clinical research and also in clinical practice to identify those who are at risk for rapid disease progression and surgery.

Eligibility criteria:
inclusion criteria: 1. children (under 18 years of age) with established diagnosis of cd involving any location by the presence of accepted clinical, radiologic, endoscopic and histologic criteria (33, 34). 2. enrolment at the time of performing ileocolonoscopy and esophageal-gastroduodenoscopy (egd) as part of clinical care for any reason. 3. children will be enrolled at any phase of the disease (at diagnosis and thereafter as required clinically). in order to ensure enough subjects with intestinal damage and since damage is progressing over time, enrolment will be stratified based on disease duration. enrolment for each stratum of disease duration will be closed after reaching the expected sample size. * 20% of enrolled children will be within 3 months of diagnosis. * 20% of children will be between 3 months and 2 years. * 20% will be 2.01 to 3 years * 40% will have disease duration over 3-years. 4. children may be enrolled in any disease activity state (pcdai 0-100). exclusion criteria: 1. young children requiring anesthesia for lack of cooperation will be excluded (since the enteric contrast cannot be administered during the 2 hours before anesthesia and it is crucial that the contrast be given just prior the test). 2. for the first 120 children only, subjects not expected to be available for 18 month follow-up, will be excluded (the last 120 subjects may be enrolled as they are not followed longitudinally).

Keywords: crohn's disease mre pelvic mri p-mri colonoscopy gastroscopy
impact of angiotensin ii receptor blockers treatment in patients with covid 19 (covid-ara2)

Conditions: COVID; Acute Respiratory Distress Syndrome

Summary: the actual pandemic infection related to sars-cov2 results in viral pneumonitis (covid-19), that may, in the more severe cases, lead the patients to the intensive care unit (icu). the more frequent presentation is acute respiratory distress syndrome (ards). to penetrate cells, sars-cov2 uses angioconvertase type 2 (ace2) as a cellular entry receptor. ace2 belong to the renin-angiotensin-aldosteron system (sraa), and ace2 levels are directly modified when sraa inhibitors are administred to patients, and ace2 level increases particularely with angiotensin ii receptor blockers (ara2) use. the aim of our study is to determine ace2 level and activity in patients with sarscov2 infection admitted to the intensive care unit (icu). covid ara2 is a propsective cohort of patient with blood sampling at the day of admission, day 3 and day 7.

the actual pandemic infection related to sars-cov2 results in viral pneumonitis (covid-19), that may, in the more severe cases, lead the patients to the intensive care unit (icu). the more frequent presentation is acute respiratory distress syndrome (ards). to penetrate cells, sars-cov2 uses angioconvertase type 2 (ace2) as a cellular entry receptor. ace2 belong to the renin-angiotensin-aldosteron system (sraa), and ace2 levels are directly modified when sraa inhibitors are administred to patients, and ace2 level increases particularely with angiotensin ii receptor blockers (ara2) use. the aim of our study is to determine ace2 level and activity in patients with sarscov2 infection admitted to the intensive care unit (icu). covid ara2 is a propsective cohort of patient with blood sampling at the day of admission, day 3 and day 7.

Eligibility criteria:
inclusion criteria: * admission to the intensive care unit, * with a proven covid infection, responsible for acute respiratory failure * agree with participation to the study. exclusion criteria: * aged under 18 * under legal protection * pregnant or breastfeeding
drug interaction study between azd3355 and nexium

Conditions: Gastroesophageal Reflux Disease

Summary: the purpose of the study is to evaluate if azd3355 and nexium interact with each other or not, i.e. show the same or altered plasma concentration profiles when co-administered compared to administered alone.


Eligibility criteria:
inclusion criteria: * provision of written informed consent * females no childbearing potential * clinically normal physical findings exclusion criteria: * clinically significant illness within 2 weeks prior to the first dose of investigational product * history of clinically significant disease * use of prescribed medication during the 2 weeks before administration of the first dose of investigational product

Keywords: reflux inhibitor gerd ppi interaction
assessing the impact of mount sinai parenting center's newborn class

Conditions: Parenting Intervention

Summary: this study is the first to evaluate the effectiveness of a newborn parenting class designed by mount sinai parenting center. the study measures how effective the class is in improving maternal knowledge on newborn care, decreasing maternal self-perceived anxiety and increasing maternal confidence.

the important role positive parenting plays in promoting a child's developmental trajectory has led to the design and implementation of many postpartum education initiatives. with 99% of babies in the u.s. born in hospitals, there is a uniqueness of being in the hospital for an extended period of time with the opportunity to educate parents on the importance of promoting early development. pediatricians are uniquely well-positioned to address both medical and developmental concerns parents may have during critical periods in a child's development, yet very few interventions are led by pediatricians. the mount sinai parenting center designed the newborn parent education and discharge class (hereafter referred to as newborn class) to address this issue. the class is 1-hour long and taught be pediatric attending and residents to all families who deliver well babies at mount sinai. the class aims to educate parents about medical issues, responsive parenting, and sleep. it is currently taught every tuesdays and thursdays. because of the limited availability of the class, not all mothers have the opportunity to attend. this research study will survey first time mothers of newborns to explore the effectiveness of attending the class. the study team hypothesizes that attending the class would result in increased knowledge on newborn care, increased confidence levels and decreased levels of anxiety. first time mothers who delivered a full-term singleton vaginally with no major complications were included in the study. only mothers who attended the class (intervention) or expressed desire to attend class but were discharged before a class was offered (control) were included in analysis. mothers were recruited between may 2018 and august 2019 at the klingenstein pavilion of mount sinai. maternal self-perceived anxiety and confidence were measured using standardized scales, and knowledge on newborn care was assessed using an internally-developed scale.

Eligibility criteria:
inclusion criteria: * first-time mother * above 18 years old * vaginal delivery of a healthy full-term singleton * no major perinatal complications (per self-report) * consent to participate. exclusion criteria: -none

Keywords: newborn care maternal anxiety maternal self-efficacy newborn care knowledge developmental trajectory positive parenting
etiology of travelers' diarrhea in australian tourists traveling to southeast asia

Conditions: Travelers Diarrhea

Summary: the study proposed here will determine the frequency and etiology of diarrhea in australian adult tourists traveling to southeast asia, including cambodia, indonesia, laos, malaysia, myanmar, the philippines, thailand, timor-leste, and vietnam. the results from this study will inform the feasibility and design of subsequent clinical trials of travelers' diarrhea interventions in this population.


Eligibility criteria:
inclusion criteria: * adult aged \> 18 years residing in australia. * planned travel for 14 to 28 days starting in the next 30 days to selected countries in southeast asia, including cambodia, indonesia, laos, malaysia, myanmar, the philippines, thailand, timor-leste, and vietnam. * willing to participate in the clinical study and available for all planned study activities through approximately 28 days post-travel. * access to a smartphone and mobile phone services while traveling (either by local sim card, wifi, or international roaming service on the individual's home-country mobile phone). exclusion criteria: * unable or unwilling to provide adequate informed consent.

Keywords: travelers diarrhea australian epidemiology
heart failure with mildly reduced ejection fraction registry

Conditions: Heart Failure

Summary: heart failure (hf) affects about 1% of patients younger than 55 years, whereas the prevalence of hf increases \> 10% in patients with at least 70 years of age. despite hf with reduced ejection fraction (hfref) and hf with preserved ejection fraction (hfpef), the clinical significance of hf with mildly reduced ejection fraction (hfmref) has gained more importance within the past years. those patients are characterized by a left ventricular ejection fraction (lvef) of 41-49%. however, within the current european guidelines, limited treatment recommendations in this subgroup of hf are yet available as a consequence of the limited number of studies in this field. the "heart failure with mildly reduced ejection fraction registry" aims to characterize patients with hfmref and investigated the prognostic impact of interventional and pharmacological therapies in this subgroup of hf patients.


Eligibility criteria:
inclusion criteria: * patients with hfmref (i.e., lvef 41-49%) * patients with at least 18 years of age exclusion criteria: * patients younger than 18 years of age