Kornimate/medical-research-clean huggingface dataset:
patient-informed educational intervention for the improvement of cervical cancer literacy

Conditions: Stage IB Cervical Cancer FIGO 2018; Stage IB1 Cervical Cancer FIGO 2018; Stage IB2 Cervical Cancer FIGO 2018; Stage IB3 Cervical Cancer FIGO 2018; Stage II Cervical Cancer FIGO 2018; Stage IIA Cervical Cancer FIGO 2018; Stage IIA1 Cervical Cancer FIGO 2018; Stage IIA2 Cervical Cancer FIGO 2018; Stage IIB Cervical Cancer FIGO 2018; Stage III Cervical Cancer FIGO 2018; Stage IIIA Cervical Cancer FIGO 2018; Stage IIIB Cervical Cancer FIGO 2018; Stage IIIC Cervical Cancer FIGO 2018; Stage IIIC1 Cervical Cancer FIGO 2018; Stage IIIC2 Cervical Cancer FIGO 2018; Stage IVA Cervical Cancer FIGO 2018

Summary: this study investigates the health literacy, cervical cancer knowledge, and radiation knowledge of patients with cervical cancer. the goal of this study is to develop a video that can improve patients 'understanding of cervical cancer and its treatment.

primary objectives: i. to assess the baseline health literacy, cervical cancer knowledge and radiation knowledge in a diverse sample of patients from two hospitals in houston, texas. (phase 1) ii. to test improvement in comprehension of cervical cancer and radiation terminology in a diverse sample of cervical cancer patients after viewing the video-based educational tool developed in this study. (phase 2) secondary objectives: i. to assess barriers to care and assess baseline radiation adherence, defined as missing no treatments and time to radiation completion, in a diverse sample of patients from two hospitals in houston, texas. ii. to describe the impact of the video on radiation treatment adherence in terms of radiation completion, defined as missing no treatments) and time to radiation completion. iii. to describe the relationships between time to radiation completion, health literacy, sociodemographics, reported barriers to care, and baseline cervical cancer knowledge and misconceptions. outline: phase i: patients complete surveys over 10 minutes on their background, health literacy level, barriers to cancer care, and knowledge of cervical cancer and its treatment. phase ii: patients watch educational video on cervical cancer. patients also complete surveys over 5-10 minutes at baseline and after watching educational video.

Eligibility criteria:
inclusion criteria: * biopsy proven carcinoma of the cervix * federation of gynecology and obstetrics (figo) stage ib-iva * n0 and n1 nodal status according to tnm staging * planned for definitive chemoradiation with curative intent * able to speak and read english or spanish * age 18 or older * able to give informed consent exclusion criteria: * physicians or nurses
ctdna and mri parameters in head and neck cancer

Conditions: Head and Neck Neoplasms; Carcinoma, Squamous

Summary: patients undergoing primary radiochhemotherapy for locally advanced head and neck squamous cell carcinomas are included in this study. in addition to standard of care treatment patients will undergo addiational blood draws and mr imaging studies. circulating cell free tumor dna will be analysed in the blood samples. biological data, imaging data and clinical data (such as patient and tumor characteristics, oncologic outcome, side effects) will be analysed in a biomathematical modelling approach.


Eligibility criteria:
inclusion criteria: * squamous cell carcinoma head and neck * planned primary platinum based radiochemotherapy * ecog 0-2 exclusion criteria: * palliative therapy intent * not mr eligible
an observational study to assess longitudinal variation of immune biomarkers in subjects at risk for development of type 1 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 1

Summary: this study is conducted in the united states of america (usa). the aim of the study is to assess longitudinal variation of immune biomarkers in subjects at risk for development of type 1 diabetes (t1d).


Eligibility criteria:
inclusion criteria: * subjects with general good health as judged by the investigator * participant tested positive at above or equal to 99th percentile for one or more of three islet antibodies (gad (glutamic acid decarboxylase), ia2 (islet antigen-2), iaa (insulin autoantibody)) exclusion criteria: * any chronic disorder (diabetes at enrolment) or severe disease which, in the opinion of the investigator, might jeopardize subject's safety or compliance with the protocol * female of child-bearing potential who is pregnant, breast-feeding, or intends to become pregnant
ultrasound-guided continuous sciatic nerve blocks: popliteal versus subgluteal catheters

Conditions: Foot Surgery

Summary: to determine the relationship between perineural catheter location along the sciatic nerve (popliteal versus subgluteal placement) and infusion effects for ultrasound-guided continuous sciatic nerve blocks.


Eligibility criteria:
inclusion criteria: * undergoing foot surgery with a sciatic perineural catheter for postoperative analgesia * spending the first postoperative night hospitalized * age 18 years or older exclusion criteria: * pregnancy * inability to communicate with the investigators and hospital staff * incarceration * clinical neuropathy in the surgical extremity

Keywords: pain surgery catheter nerve block popliteal subgluteal sciatic ucsd moderate-to-severe pain perineural catheter orthopedic surgery foot surgery surgery sciatic perineural catheter age =>18
randomized, standard-controlled, study to evaluate the ohana ivf sperm preparation kit, spertility ivf next generation

Conditions: Infertility; Infertility, Male

Summary: multi-centered, randomized controlled study, evaluating the safety and efficacy of the ohana ivf sperm preparation kit vs. a standard ivf sperm preparation kit.

this blinded, randomized, standard-controlled, paired study will be performed in approximately 83 healthy couples (pairs of male and female subjects), who are appropriate candidates for ivf in six fertility centers located in the united states (us). the study will capture the selection of the best embryo for transfer and follow-up on pregnancy outcomes that result from the transfer of the selected embryo following the ivf procedure, and the results of safety assessments.

Eligibility criteria:
inclusion criteria: (sample) female inclusion criteria: 1. premenopausal, age 25-37 years at the time of providing informed consent, who is an appropriate candidate for ivf. 2. infertility for ≥ 12 months with regular intercourse with current male partner (or \>6 months if age \>35). 3. regular menses defined as 25 to 35-day cycles or an average of 10-13 spontaneous menstrual periods per year without exogenous hormones. 4. amh between 1.8 - 4.9 ng/ml based on screening measurement at central laboratory. 5. afc \>14 within 3 months of screening visit. male inclusion criteria: 1. willing and able to provide semen specimens at the screening visit and on the day of oocyte retrieval; (the specimen provided must be suitable for conventional ivf). 2. provide a semen specimen with at least 4 million total motile sperm, following density gradient centrifugation and washing of the sample, at the screening visit. exclusion criteria: (sample) female exclusion criteria: 1. recurrent pregnancy loss (defined as \>2 clinical pregnancies without live birth). 2. contraindications to being pregnant or to any of the ivf hormonal modulating medications to be used in this study. 3. history of severe ovarian hyperstimulation syndrome (ohss) requiring medical or surgical intervention. 4. clinically diagnosed polycystic ovarian syndrome (pcos.) 5. gynecologic history of: pelvic surgery (prior diagnostic or nonoperative laparoscopy, hysteroscopy or operative hysteroscopy are allowed. 6. tobacco or nicotine use in the past 12 months. 7. history of substance abuse, including alcohol abuse. 8. abnormal, undiagnosed, vaginal bleeding at the time of screening. male exclusion criteria: 1. history of: vasectomy or vasectomy reversal. 2. inability and/or unwillingness to provide semen specimens. 3. tobacco or nicotine use in the past 12 months. 4. history of substance abuse, including alcohol abuse. 5. marijuana use in the past 12 months.
characteristics and medical resource utilization of postoperative patients

Conditions: Pain, Postoperative

Summary: the objective of this study is to assess and analyze the characteristics and usage of conventional and korean medical services in postoperative patients. this study therefore investigates the proportion of patients with a history of surgery out of patients visiting a spine-specialty korean medicine hospital, and the prognosis and preference for conventional and korean medicine treatment by previous treatment history in postoperative patients.

a considerable number of patients suffer prolonged chronic pain that does not retract or diminish after surgery, and are thus unable to achieve the desired results in receiving surgical treatment. postoperative pain is gradually being perceived as a social issue as opposed to a personal health condition. meanwhile, although efforts to address chronic pain with integrative medicine are continued in answer to the lack of success of pain management through surgery, there is still a lack of supporting evidence. the objective of this survey study is to assess the characteristics, usage of conventional and korean medical services, and prognosis by period before and after surgery in postoperative patients visiting a korean medicine hospital, and analyze the associations between the preference for conventional and korean medicine treatment. this study therefore investigates the usage of conventional and korean medical services in postoperative patients, and is expected to provide information that will potentially aid patient decision making.

Eligibility criteria:
inclusion criteria: * patients with chief complaint(s) of at least one or more of the following: low back pain (or radiating leg pain), neck pain (or radiating arm pain), knee pain, or shoulder pain * patients with a history of musculoskeletal surgery related to the chief complaint(s) * patients capable of effective communication with the researcher(s) and understanding the survey items * patients who have given written informed consent exclusion criteria: * patients without a history of musculoskeletal surgery associated with the low back, neck, shoulder, or knee region(s) * patients whose current pain is mainly attributed to traffic accident injury * patients incapable of answering the researcher interviews and surveys * patients with other reasons rendering study participation inappropriate as judged by the researcher(s)

Keywords: postoperative pain failed back surgery syndrome korean medicine
nitrous oxide analgesia vaso-occlusive crisis

Conditions: Sickle Cell Disease; Vaso-occlusive Crisis

Summary: patients who have sickle cell voc are usually treated with opioids, such as morphine. however, this current way of treating them has not improved the health, medical outcomes, or rates of hospitalizations. in addition, since voc can happen very frequently over a long period of time, giving opioids over and over again can cause both short-term and long-term problems. nitrous oxide (n2o) is a way of treating pain that may provide a better alternative to repeatedly giving opioids over long periods of time. n2o has been shown to provide up to 3 hours of pain relief in inpatient patients with voc whose pain did not improve with morphine infusions, and is used extensively in france, where almost half of 85 pediatric emergency departments use nitrous oxide to treat children with voc whose pain did not get better with standard treatment with morphine. however, pain relief which n2o provides in the acute setting has not been well described. therefore, the purpose of our study is to describe how well n2o can relieve the pain in patients with scd who present to the emergency department and are experiencing a voc.


Eligibility criteria:
inclusion criteria: * patients with sickle cell disease * ages 8 to 18, inclusive * present to the pediatric emergency department with voc and whose pain scores remain greater than or equal to 7/10 on the nrs after initial standard treatment (i.e. iv fluids, morphine and nsaids). exclusion criteria: * life-threatening illness as determined by attending clinician * developmental delay * altered level of consciousness * any contraindications to receiving n2o * foster children and wards of the state

Keywords: sickle cell disease vaso-occlusive crisis nitrous oxide emergency department
effects of compound probiotics-polygonatum sibiricum on liver health and metabolism in middle-aged and elderly people

Conditions: Fatty Liver

Summary: the purpose of this study was to evaluate the regulatory effects of huangqian-biobacteria compound preparation on liver health and related metabolic disorders in middle-aged and elderly people, observe its effects on liver function indexes, basal metabolic rate, markers of oxidative stress, inflammatory factors and intestinal microecology, and evaluate the incidence of adverse reactions in subjects during the 3-month intervention period.


Eligibility criteria:
inclusion criteria: 1. the age of the subjects is 40-80 years old; 2. the subject meets one of the following metabolic disease components: ① abdominal b - ultrasound shows fatty liver or fat infiltration; ② arterial blood pressure is higher than 130/85mmhg, or the subject is on antihypertensive treatment; ③ prediabetes or type 2 diabetes, with fasting blood glucose above 6.1mmol/l; ④ overweight or obesity, with bmi of 24.0kg/m² or more, or male waist circumference of 90cm or more, female waist circumference of 85cm or more, or excessive body fat content and percentage. - exclusion criteria: 1. people who are allergic to any of the pharmaceutical ingredients used in this study; a history of alcohol abuse (drinking more than 14 units of alcohol per week :1 unit = 285ml for beer, 25ml for spirits, 100ml for wine); 2. patients who received probiotics within 1 month before taking the experimental drug; 3. recent history of gastrointestinal bleeding, obstruction, perforation, tumor and other serious organic diseases; 4. aminotransferase index \> 3 times the normal value; 5. kidney disease (creatinine index higher than normal); 6. patients with serious psychological and mental diseases, resulting in the inability to express themselves normally; 7. patients with infectious liver diseases, such as hepatitis b and c; 8. the female subject is breastfeeding or has a positive pregnancy test result during the screening period or during the test -
efficacy, safety, and tolerability of oxcarbazepine monotherapy in children with partial seizures

Conditions: Epilepsy, Partial Seizures

Summary: this study is aimed to collect additional data regarding the efficacy in reducing the frequency of partial seizures, as well as the safety and tolerability, of oxcarbazepine monotherapy in children.


Eligibility criteria:
inclusion criteria: * males and females, 6 months - 17 years of age; * diagnosis of epilepsy, partial seizures; * ineffective or intolerable present therapy with 1 antiepileptic drug, or none of previous antiepileptic therapy exclusion criteria: * progressive lesion of brain revealed by ct/mri that performed no earlier than 2 years prior to screening; * non-epileptic seizures; * drug or alcohol dependence during a year prior to screening; other protocol-defined inclusion/exclusion criteria may apply.
sleep disturbances in surgical patients with gi cancers: a quantitative and qualitative analysis

Conditions: GI Cancers; Gastrointestinal Cancer

Summary: the primary objective of the study is to determine sleep disturbance and its types among patients with gastrointestinal cancers during the perioperative period (preoperative and in-hospital stay following surgery) by using richard campbell sleep questionnaire (rcsq). the primary objective of this study is to determine the sd during preoperative and post-operative periods evaluated by richard campbell sleep questionnaire. patients will be asked every 24 hours while at the hospital (before and after surgery) to fill out this questionnaire. the mean rcsq score at each time point (i.e., before and after surgery) will be calculated for each patient. the overall mean (across all patients) will be calculated and reported along a 95% ci.

primary: • determine sleep disturbance and its types among patients with gastrointestinal cancers during the perioperative period (preoperative and in-hospital stay following surgery) by using richard campbell sleep questionnaire(rcsq). secondary: * determine sleep disturbance and its types at 30 day post-discharge follow-up visit by rcsq. * determine the correlation between objective sleep variables assessed using actigraphy and fitbit and patient-reported sd on richard campbell sleep questionnaire. * determine the association of severity and impact of sd among quality of recovery (qor-15), pittsburgh sleep quality index, mdasi-gi and richard campbell sleep questionnaire, and insomnia severity index (isi). exploratory: • determine the association between the preoperative inflammatory burden, sleep health {insomnia (using insomnia severity index (isi)),sleep architecture(sleep-wake cycles usingactigraphy)}, and perioperative inflammatory responses on postoperative sd

Eligibility criteria:
inclusion criteria: 1. adult gi cancer patients admitted for elective gastrointestinal surgery. 2. patients with an expected hospitalstay of at least 72 hours. 3. able to be able to read and speak english. 4. must have access to internet or use of mobile device for fitbit. exclusion criteria: 1. \<18 years of age. 2. night shift workers. obtained from job history, any patient \>/= 2 days per week, within the last six months prior consenting, are not eligible.
foot plantar pressure changes after plantar dry needling

Conditions: Myofascial Pain Syndrome; Foot Diseases

Summary: the aim of this clinical trial is to check the effects of dry needling in the flexor digitorum brevis. twenty healthy subjects wil be recruited for a quasi-experimental study. participants will be from 18 to 40 years old, not obese. participants will be measured before and after bilateral dry neddling in flexor digitorum brevis. the investigators will measure static footprint variables. the footprint variables will be divided in bilateral rear foot, bilateral midfoot, bilateral fore foot.


Eligibility criteria:
inclusion criteria: * flat foot grade ii or ii with * must have latent trigger point in flexor brevis digitorum muscles exclusion criteria: * previous lower extremities surgery. * history of lower extremities injury with residual symptoms (pain, "giving-away" sensations) within the last year. * leg-length discrepancy more than 1 cm
comparison of the ankle-brachial index measurement using a specific oscillometric device vs. the doppler method

Conditions: Peripheral Arterial Disease, Ankle Brachial Index, Doppler

Summary: several methods are available to measure ankle brachial index (abi) non-invasively. a recent scientific statement of the aha considers the doppler method as the reference. however because doppler devices are not widely available in primary care, several attempts have been made to propose alternative methods, among whom oscillometric methods (automatic blood pressure machines) have attracted most attention. we hypothesize that: - the diagnostic characteristics (i.e. sensitivity, specificity and auc) of the oscillometric method would be very good as compared to the doppler method. the oscillometric method would have better intra- and inter-observer reproducibilities as compared to the doppler method.


Eligibility criteria:
inclusion criteria: patients referred with the suspicion of pad, either because of: * symptoms in favor of intermittent claudication or more atypical pain when walking, or * asymptomatic individuals with the presence of at least 2 cardiovascular risk factors among the following : * men \> 60 years or women \> 65 years * regular cigarette smoking \>10 years, either current or in the past * treated type-2 diabetes \>5 years or type-1 diabetes \>20 years * treated hypertension * high blood cholesterol (either total-c \>240 mg/dl or ldl-c \>160 mg/dl) or treated by statins or other lipid-lowering agents * documented history of coronary artery disease (history of pci or cabg, or previous myocardial infarction, or cad documented by coronary angiography) * documented history of ischemic stroke exclusion criteria: * patients with revascularized pad * patients with critical limb ischemia or leg/foot ulcers * cardiac arrhythmia: atrial fibrillation, atrial flutter, frequent supra- and ventricular ectopic beats * patients under dialysis
evaluating the efficacy of cranial electrotherapy stimulation in mitigating anxiety-induced cognitive deficits

Conditions: Anxiety; Cognitive Deficit

Summary: this study investigates the potential of cranial electrotherapy stimulation to mitigate anxiety induced cognitive deficits


Eligibility criteria:
inclusion criteria: * between 18-28 years old exclusion criteria: * history of diagnosis with a neurological or psychiatric disorder.

Keywords: cranial electrotherapy stimulation executive functioning induced anxiety cognition threat of shock heart rate variability
vestibular and motor functions in children with hemiplegic cerebral palsy

Conditions: Cerebral Palsy; Hemiplegic Cerebral Palsy

Summary: as many researches have been conducted to see the effects of vestibular system activation on gross motor activities of children with cerebral palsy but there are limited researches on improvement of motor abilities of hemiplegic cerebral palsy child using ueu or bosu ball or treadmill in a single study. there is lack of research on vestibular stimulation in hemiplegic cerebral palsy along with neurodevelopmental treatment. this study will improve the gross motor activities of children with hemiplegic cerebral palsy. it will broaden up the ways for physical therapist to deal with this type of cerebral palsy (hemiplegic).

there are various therapeutic approaches that are used to improve motor activities and postural control in cp child. among these approaches vestibular stimulation is used to improve neuromotor development by different sensory stimulation techniques. it has shown positive effects on motor control of cp child. it also influences all sensory experiences and is an exercise based approach.

Eligibility criteria:
inclusion criteria: * age: 3 years to 12 years * gender: both male and female * children with spastic hemiplegic cp scoring 1,1+ and 2 on modified ashworth scale * level iii and iv on gmfcs (gross motor function classification system) exclusion criteria: * children with other types of cerebral palsy (diplegia, quadriplegia etc) * children with other abnormalities and pathologies (delayed milestones, hydrocephalous, epilepsy etc) * children undergone any kind of surgery (cardiac, shunt placement, orthopedic etc) * children with any other neurological deficits (spina bifida etc) * children with conditions in which vestibular stimulation is not allowed (paroxysmal positional vertigo or vestibular neuritis, meniere's disease, migraine-associated vertigo, and childhood vertigo).

Keywords: motor activity spasticity vestibular stimulation