Kornimate/medical-research-clean huggingface dataset:
a study on the prospective cohort library of covid-19 in southeran

Conditions: Follow-up; COVID-19; Infectious Diseases; Respiratory

Summary: this is a multi-centre population-based follow-up study for all 504 patients with laboratory-confirmed covid-19. this study establishes a standardized and structured clinical database to provide complete and multidimensional clinical diagnosis and treatment data of novel coronavirus pneumonia, which also support future epidemiological, infectious disease study and patients' prognosis, by collecting clinical data and the related data of patients with novel coronavirus pneumonia in southern zhejiang province.

the follow-up information will be collected in one-month, three-month, six-month and one-year after discharge. information about symptoms, radiographic and laboratory findings, lung function, sf-36 questionnaire, antibody of covid19，result of rt-pcr test and suvival information will be collected through all time frames.

Eligibility criteria:
inclusion criteria: * all patients with laboratory-confirmed covid-19 in wenzhou exclusion criteria: * suspected cases of covid-19
a post market study to assess the spinal modulation neurostimulator system for chronic intractable pain

Conditions: Chronic Pain

Summary: 04-smi-2012 is post market, observational, questionnaire based study to assess the effectiveness of the commercially available axium neurostimulator in the management of chronic, intractable pain.


Eligibility criteria:
inclusion criteria: 1. subject is at least 18 years old 2. subject is able and willing to comply with the follow-up schedule and protocol 3. chronic, intractable pain in the thoracic, lumbar and/or sacral distribution(s) for at least 6 months 4. failed conservative treatments for chronic pain including but not limited to pharmacological therapy, physical therapy and interventional pain procedures for chronic pain 5. minimum baseline pain rating of 60 mm on the visual analog scale in the primary region of pain 6. in the opinion of the investigator, the subject is psychologically appropriate for the implantation for an active implantable medical device 7. subject is able to provide written informed consent 8. subject speaks dutch or english exclusion criteria: 1. female subject of childbearing potential is pregnant/nursing, plans to become pregnant or is unwilling to use approved birth control 2. escalating or changing pain condition within the past month as evidenced by investigator examination 3. subject has had corticosteroid therapy at an intended site of stimulation within the past 30 days 4. subject has had radiofrequency treatment of an intended target dorsal root ganglion within the past 3 months 5. subject currently has an active implantable device including implantable cardioverter defibrillator, pacemaker, spinal cord stimulator or intrathecal drug pump 6. patient has pain only or primarily within a cervical dermatomal distribution 7. subject is unable to operate the device 8. subjects with indwelling devices that may pose an increased risk of infection 9. subjects currently has an active infection 10. subject has, in the opinion of the investigator, a medical comorbidity that contraindicates placement of an active medical device 11. subject has participated in another clinical investigation within 30 days 12. subject has a coagulation disorder or uses anticoagulants that, in the opinion of the investigator, precludes participation 13. subject has been diagnosed with cancer in the past 2 years
effects of upper extremity rehabilitation robot and transcranial direct current stimulation in subacute stroke

Conditions: Stroke

Summary: comparison of real transcranial direct current stimulation (tdcs) and sham tdcs combined with robot training for upper extremity rehabilitation.


Eligibility criteria:
inclusion criteria: * hemiplegic patients secondary to first cerebrovascular accidents * onset ≤ 6 months * fugl-meyer assessment score ≥ 19 * cognitively intact enough to understand and follow the instructions from the investigator exclusion criteria: * severe upper extremity pain that could interfere with rehabilitation therapy * neurological disorders other than stroke that can cause motor deficits * uncontrolled severe medical conditions.

Keywords: stroke transcranial direct current stimulation upper extremity rehabilitation robot
decide: developing tools for lung cancer screening discussion improvement

Conditions: Smoking; Smoking, Tobacco; Smoking, Cigarette; Lung Cancer

Summary: the purpose of this study is to learn about discussion between clinicians and their patients related to lung screening. survey answers will be collected from both clinicians and their patients.


Eligibility criteria:
inclusion criteria: clinicians: * clinician (physician, nurse practitioner, or physician assistant) * practicing in a kpwa primary care clinic * having a patient panel with \>/= 10 lung cancer screening eligible patients patients (quantitative phase): * age 55-80 years * \>/= 30 pack-year tobacco smoking history * current smoker or former smoker who has quit within the past 15 years * documented sdm lung cancer screening discussion during a recent clinic visit exclusion criteria: patients: * significant comorbidities (charlson comorbidity index \>/=3) * lung cancer diagnosis

Keywords: smoker memorial sloan kettering cancer center
the fragility of metaphors (frame): learning, loosing, and how to train them

Conditions: Schizophrenia; Psychosis

Summary: tracking down the difficulties in metaphor comprehension experienced by individuals with schizophrenia across different metaphor types and exploring the neurological correlates via eeg recording technique

the investigators will address the following objectives: * primary objective: tracking down the difficulties in metaphor comprehension experienced by individuals with schizophrenia across different metaphor types and exploring the neurological correlates via eeg recording technique * secondary objectives: 1) evaluate the interactions between performances in metaphor comprehension and individual differences in psychopathology, cognition, tom and functioning; 2) test if the altered neurophysiological patterns associated to the fragility of metaphor comprehension in schizophrenia can be restored through a rehabilitative training the investigators will enroll 32 schizophrenic patients and 32 healthy subjects as control sample. participants will undergo an initial visit with a specialist psychiatrist who will verify that their conditions meet the criteria required by the study. then, subjects will be tested for metaphor comprehension, as well as for the other variables included in the study, and the electrical brain activity will be registered through a 128 channel eeg. in the check-up visits (i.e., after the training) the following data will be collected: * scores relating to cognitive, pragmatic (understanding of metaphors), theory of mind and global functioning performance scores * eeg recordings related to the process of understanding metaphors * scores on scales that evaluate psychopathological severity

Eligibility criteria:
inclusion criteria: for patients: * age between 18 and 65 years * diagnosis of schizophrenia according to dsm v criteria * ability to provide informed consent for healthy controls: * age between 18 and 65 years * ability to provide informed consent * absence of psychiatric pathologies * ability to speak italian exclusion criteria: for patients: * intellectual disability * neurological disorder for healthy controls: * presence of psychiatric pathologies * difficulties in speaking italian

Keywords: language pragmatics rehabilitation electrophysiology
stent thrombosis in acute coronary syndromes

Conditions: Stent Thrombosis; Acute Coronary Syndrome

Summary: the purpose of this study is to better understand what treatment methods result in the best outcomes for patients who have heart attacks due to blood clots forming within stents.

this is a multicenter registry that examines treatment strategies and outcomes in patients who present with acute coronary syndrome (acs) due to stent thrombosis in the coronary arteries. this study will take place at potentially 8 medical centers throughout the state of california. a total of 800 patients will be enrolled into the registry, 100 patients from each of the eight participating california medical centers. uc davis will serve as the core lab for this study. eligible subjects, patients who present to the hospital (medical center) with acs due to stent thrombosis and receive a cardiac catheterization to treat the stent thrombosis, will be included in the retrospective analysis of this cardiac condition. subjects who expire in hospital due to acs with stent thrombosis will also be included in the retrospective analysis of this clinical registry. patients, who consent for approval, will become eligible to participate in the 3-year prospective follow-up phase of the clinical registry. these patients will be followed for three years to learn more about long term clinical outcomes for this disease state. there are no specific/special procedures required for this clinical registry. this is a registry for data collection only to correlate prescribed medical care with individual short- and long-term clinical outcomes.

Eligibility criteria:
inclusion criteria: * subject's age range will be ≥ 18 years old. * subjects will have an existing drug-eluting or bare metal stent. * subjects will have presented to the medical center with acute coronary syndrome due to stent thrombosis as identified via cardiac catheterization. exclusion criteria: * inability to consent/declined to participate in the prospective arm of the clinical registry.

Keywords: stent thrombosis acute coronary syndrome acs stenting interventional cardiology cardiology cardiovascular research registry
hands on vs hands off for perineal laceration

Conditions: Perineal Tear

Summary: perineal trauma at the time of vaginal delivery is common, and when the anal sphincter is included, these injuries can be associated with additional morbidity including incontinence, pelvic pain and sexual dysfunction. techniques studied include hands-on vs hands-off, perineal massage, warm compresses, ritgen maneuver, and others. it is unclear if a hands-on technique decreases the incidence of perineal trauma compared to a hands-off technique

different strategies have been adopted in the late first and/or second stage of labor to decrease the incidence of perineal lacerations. these strategies include not only the hands-on technique, but also warm compresses, perineal massage, the use of oil or jelly, the ritgen maneuver and a new perineal protection device. the review by aasheim reported a decreased risk of third- and fourth-degree lacerations in the perineal massage group (two studies, rr 0.52, 95% ci 0.29 to 0.94).4 this review also showed a similar reduction in third- and fourth-degree lacerations with warm compresses (two studies, rr 0.48, 95% ci 0.28 to 0.84), but no significant changes with use of a ritgen maneuver. additional reviews have evaluated delayed versus immediate pushing, with no significant difference in perineal trauma. regarding how the interventions may work, initially the hands-on technique was hypothesized to control the velocity of the crowning process and therefore decrease perineal trauma. given the fact that the hands-on approach has been found to be possibly associated with more perineal lacerations instead of less, some have proposed that the harm may be caused by the hands-on approach's additional pressure resulting in some perineal ischemia. moreover, using one intervention (e.g. hands-on) may predispose to use other interventions (e.g. episiotomy), which have themselves been proven to increase perineal trauma. perhaps a combination of perineal interventions, such as massage or compresses, with a hands-off approach and avoidance of episiotomy, will prove to show improved perineal outcomes. larger studies, including evaluation specific for nulliparous subjects, are required to make definitive recommendations for management.

Eligibility criteria:
inclusion criteria: * singleton gestations * low risk pregnancies * 37 to 42 weeks of gestations exclusion criteria: * multiple gestations * preterm birth
adjuvant therapy for intrauterine adhesions between two groups

Conditions: Asherman Syndrome

Summary: this study was taken out to compare two mechanical devices (intrauterine balloon and intrauterine contraceptive device plus foley catheter) in the therapy for intrauterine adhesions after hysteroscopic adhesiolysis. participates were assigned into two groups by randomly.

intrauterine balloon and intrauterine contraceptive device plus foley catheter are both effective in the therapy for intrauterine adhesion. the intrauterine contraceptive device plus foley catheter are usually inserted into the uterine after hysteroscopic adhesiolysis. foley catheter is removed after three days while intrauterine device is removed two or three month later. the heart-shaped intrauterine balloon is designed to fit into the cavity of the uterus, and usually removed on the 7th day after surgery.

Eligibility criteria:
inclusion criteria: * moderate to severe intrauterine adhesion (afs score ≥5） * agreement to have a second-look hysteroscopy * no previous history of hysteroscopic adhesiolysis exclusion criteria: * minimal adhesion (afs score\<5) * previous hysteroscopic adhesiolysis

Keywords: intrauterine balloon intrauterine device plus foley balloon catheter asherman syndrome
focused shock wave therapy outcomes in peyronie's disease and erectile dysfunction

Conditions: Peyronie Disease; Penile Curvature; Erectile Dysfunction

Summary: the purpose of this research is to determine the pure or additional effects of penile shockwave therapy with low intensity linear shock wave machine for penile curvature (and/or erectile dysfunction) vs patients' undergoing other treatments (including xiaflex therapy, patients that have undergone older generations of swt, or medical treatment).


Eligibility criteria:
inclusion criteria: * peyronie's disease (pd) at any stage * the presence of penile plaque or pain at erection or curvature * pd therapy with or without simultaneous intralesional xiaflex injection. exclusion criteria: * prior penile surgery or liswt. * erective dysfunction (ed) not responding to phosphodiesterase-type five inhibitors or intracavernosal injections. * unwillingness or inability to provide informed consent. * having active or life-threatening coagulopathies ore using anti-coagulation /anti-platelet medications
exhibitionnists's cognitive mecanisms

Conditions: Paraphilic Disorders; Exhibitionism

Summary: exhibitionism is a paraphilia, which is defined according to the dsm 5. the estimated prevalence in men is between 2 to 4% (the prevalence of exhibitionistic disorder in females is even more uncertain but is generally believed to be much lower than in males). at judiciary level: approximately 30% of apprehended male sex offenders are exhibitionists. they have the highest recidivism rate of any sex offender; about 20-50% are arrested again. the studies are old and not very prolific on the subject of exhibition. the available data are lacking, there is no clinical evaluation scale for exhibitionism. the diagnosis is essentially based on facts with judicial characteristics "did patient show himself? ", "does he enjoy showing off?". investigators have no data on the cognitive distortions that support this particular acting out, the (specific) triggering factors and the potential psychological vulnerabilities of exhibitionists some cognitive and sensory mechanisms may be involved in the origin and development of the processes underlying the act (johnston and ward 1996). the investigators will rely on the identification of anticipatory, relieving and permissive beliefs as a schema that can explain cognitive processes leading to acting out (johnston and ward, 1996). the goal is to apply this approach to exhibitionism. it should be noted that this model of thoughts (anticipatory, relieving and permissive) is taken up in the field of addiction. exhibition is generally presented in the literature as a possible addictive disorder (jon e. et al). the investigators will investigate whether there are specific factors precipitating exhibitionnism's acting out, other than the general precipitating factors or the recidivism risk factors known in sexual violence (sonar, static-99, pcl- r, svr-20...). the investigators will also study the psychological vulnerabilies of these subjects.


Eligibility criteria:
inclusion criteria: * male \> 18 years * followed in resource centre for interveners with perpetrators of sexual violence of montpellier uh * exhibitionnists * agree to participate exclusion criteria: * dementia * severe intellectual desability * decompensated psychiatric didease

Keywords: sex offender sexual violence acting out
analgesic effects of extraoral ultrasound block of mandibular nerve for the extraction of lower third molars

Conditions: Molar; Impacted Teeth

Summary: this is a study about the dynamics and effects of different types of blocks (intraoral conduction anesthesia of the alveolar nerve and extraoral us block of the mandibular nerve) for extraction of lower third molars.

standard method of anesthesia for extraction of horizontally positioned lower thirdmolars is intraoral conduction anesthesia of the inferior alveolar nerve. however, the analgesiceffect of block is short and it is necessary to use analgesics. in this prospective clinical study,analgesic effect of ultrasound (us) -guided extraoral block of mandibular nerve will beinvestigated, in order to prolong pain-free time and reduce the use of analgesics associated withrisks (bleeding, hepatotoxicity). characteristics of alveolar nerve block and us block of the mandibular nerve will becompared, such as: pain during application of anesthesia, amount of anesthetic, duration ofanesthesia, need to use analgesics, time to and level of pain when using analgesics, andcomplications

Eligibility criteria:
inclusion criteria: * age 18-64 years * horizontally placed lower third molars * asa i or ii group exclusion criteria: * allergy to local anesthetics * local infection at the site of needle puncture * parotitis * serious liver disease * use of antiarrhythmics group iii (eg amiodarone), anticoagulant or antithrombotic drugs * lactation * people who took an analgesic as a preventive measure before coming to the procedure

Keywords: dental anesthesia inferior alveolar nerve regional anesthesia ultrasound mandibular nerve
risk factors for stress-induced alcohol misuse: genetic predictors and mediation by personality type

Conditions: Alcohol Use, Unspecified

Summary: to examine whether variation in 'risk-taking' personality and linked genetic variants predicts susceptibility to, and resilience against, stress-induced alcohol misuse.

alcohol misuse is a global health issue responsible for over 1 million hospital admissions per annum in the uk with a combined cost of approximately £21 billion. chronic alcohol misuse in patients who attend hospital for alcohol-related illness/injury is common, with relapse and recidivism almost ubiquitous. patients often report that 'stress' was a catalyst for their drinking episodes, but we do not know exactly who is most at risk, how stress leads to drinking, or the genetic basis for this risk. this research aims to seek to identify patients at higher risk of stress-induced alcohol misuse, or who are more resilient to stress in this context, using a combination of analyses ranging from genetic variants to personality tests and clinical follow-up. the ultimate goal is that patients engaging with alcohol services can receive personalised and focussed treatment and enhance recovery

Eligibility criteria:
inclusion criteria: * male or female, aged (min) 18 years * attended portsmouth hospitals university trust following illness/injury related to alcohol use * has a maximum audit score of 15 * is willing and able to comply with study procedures * willing and able to give informed consent for participation in the study. * must be recruited within 24 hrs of asns referral, and able to be tested within 48 hours of referral exclusion criteria: ny reported/suspected intellectual/learning disabilities (e.g., down's syndrome), neurodevelopmental disorders (e.g., autism, asperger's) or acquired brain injury * has previously participated in this study * should not be under the influence of alcohol during the study (12hrs previous to taking part) - to be determined via breathalyser. * any history of advanced liver disease (clinical diagnosis of cirrhosis, jaundice, encephalopathy, ascites, variceal haemorrhage)
internet-based vs face-to-face treatment for alcohol dependence

Conditions: Alcohol Abuse; Alcohol Dependence; Harmful Alcohol Use; Alcohol Use Disorder

Summary: a brief treatment program (mi/cbt) via face-to-face or via internet is tested in association with an outpatient addictions clinic.

a 5-module program based on motivational interviewing (mi) and cognitive behavioral therapy (cbt) is tested among help-seekers at one outpatient clinic within the stockholm center for dependency disorders: riddargatan 1.the design is a two-armed randomized controlled non-inferiority study, and outcomes are measured in terms of changes in alcohol consumption, problematic alcohol use, alcohol dependence alcohol use disorder, anxiety, as well as depression and quality of life. 600 participants are recruited online from the clinic's website. consenting participants will complete baseline questionnaires online and participate in face-to-face assessment by a physician at the clinic. eligible individuals will then be randomized into one of two groups: 1.internet-based treatment program with online counselor support. 2. face-to-face treatment with 5 individual counselor sessions at the clinic. follow-up will be conducted online after 3, 6, 12 and 24 months in both groups.

Eligibility criteria:
inclusion criteria: * audit-score ≥16 points and/or fulfilling at least 3 criteria of alcohol dependence (icd-10) exclusion criteria: * risk of severe withdrawal symptoms. * risk of suicide. * other psychiatric diagnosis that requires current treatment. * need for medication for alcohol dependence. * inadequate swedish language skills. * no internet access
a study of avastin (bevacizumab) plus crossover fluoropyrimidine-based chemotherapy in patients with metastatic colorectal cancer.

Conditions: Colorectal Cancer

Summary: this study will evaluate the efficacy and safety of adding bevacizumab to crossover fluoropyrimidine-based chemotherapy in patients with metastatic colorectal cancer who have experienced disease progression under first line treatment with standard chemotherapy plus bevacizumab. participants will receive chemotherapy alone, or in combination with bevacizumab. the anticipated time on study treatment is until disease progression or unacceptable toxicity occurs. participants are allowed to continue on bevacizumab, even after stopping chemotherapy.


Eligibility criteria:
inclusion criteria: * adult patients, \>=18 years of age * metastatic colorectal cancer and disease progression * previously treated with first-line chemotherapy plus avastin * eastern cooperative oncology group (ecog) performance status \<=2. exclusion criteria: * diagnosis of progression of disease more than 3 months after last avastin administration * first-line patients with progression-free survival in first-line of \<3 months * patients receiving less than 3 consecutive months of avastin in first-line therapy * past or current history (within the last 2 years prior to treatment start) of other malignancies, except for curatively treated basal and squamous cell cancer of the skin or in situ cancer of the cervix * clinically significant cardiovascular disease within 6 months prior to start of study treatment * known central nervous system (cns) disease, except for treated cns metastases as defined by protocol