Kornimate/medical-research-clean huggingface dataset:
blood flow restriction training in acl surgery

Conditions: Anterior Cruciate Ligament Injuries

Summary: this will be a randomized pilot study to determine the effectiveness of personalized blood flow restriction (pbfr) technique in conjunction with prescribed physical therapy (pt) in a cohort of anterior cruciate ligament (acl) reconstruction subjects

this will be a randomized pilot study to determine the effectiveness of personalized blood flow restriction (pbfr) technique in conjunction with prescribed physical therapy (pt) in a cohort of anterior cruciate ligament (acl) reconstruction subjects. both groups of subjects will undergo unilateral acl reconstruction at university of arkansas for medical sciences (uams), followed by prescribed pt at the uams orthopedic clinic at colonel glenn. up to 25 subjects will be enrolled. half are randomized to the bfr group with the other will perform pt without bfr. data collection will occur at four approximate occasions: pre-surgery, 8-weeks postop, 12-weeks postop, and 16-weeks postop.

Eligibility criteria:
inclusion criteria: 1. men and women, ages 18-34 years. 2. scheduled to undergo elective acl surgery at uams. 3. capable of providing informed consent. 4. willing to exercise with bfr. 5. covid-19 negative or asymptomatic. exclusion criteria: 1. any surgical indication other than acl repair. 2. body mass index \>40. 3. pregnant female. 4. neurological, musculoskeletal, or other disorder that would preclude them from completing the exercise training intervention and all performance tests. 5. hypertension as evidenced by systolic bp \>150 at rest or diastolic bp \>85 at rest. 6. heart failure as evidenced by use of prescription diuretics. 7. history of atrial fibrillation. 8. oxygen saturation \<95% on room air at rest. 9. any other medical condition that would interfere with testing or increase one's risk of complications during exercise. 10. currently receiving androgen (e.g., testosterone) or anabolic (e.g., gh, igf-i) therapy. 11. compromised vascular circulation in the legs (e.g. peripheral vascular disease). 12. history of deep vein thrombosis. 13. varicose veins in the legs. 14. known sickle cell disease or trait. 15. unwilling to avoid using protein or amino-acid supplements during participation. 16. unwilling to avoid using bfr during prescribed post-operative physical therapy.
interscalene block and dysfunction diaphragmatic

Conditions: Diaphragmatic Paralysis

Summary: the study seeks to show that interscalene injection of a small volume (\<8ml) of ropivacaine at a low concentration (0.1%) reduces the frequency of hemi-diaphragmatic paresis compared to low volume injection at the standard concentration (0.5%) in patients undergoing arthroscopic shoulder surgery with isb.

it's a prospective monocentric randomized controlled clinical trial in 2 parallel groups in double blind. the study concerns patients undergoing arthroscopic shoulder surgery with isb. the study seeks to show that interscalene injection of a small volume (\<8ml) of ropivacaine at a low concentration (0.1%) reduces the frequency of hemi-diaphragmatic paresis compared to low volume injection at the standard concentration (0.5%) in patients undergoing arthroscopic shoulder surgery with isb. randomization in one of the two arms: * experimental group: \<8ml ropivacaine 0.1%. * control group: \<8ml of ropivacaine 0.5%. evaluation of diaphragmatic stroke by ultrasound and ventilatory function by spirometry and snip test before performing the isb, then after installation of the isb. performing the surgical procedure under general anesthesia assessment of postoperative analgesia and patient satisfaction during the following 48 hours.

Eligibility criteria:
inclusion criteria: * orthopedic surgery compatible with interscalene block * french speaking * patient who signed consent to participate in the study exclusion criteria: * pregnant woman * asa score \> 3 * severe chronic respiratory insufficiency * copd \>3 or 4 of gold score * coagulation trouble * allergic to medication involved in the study * breastfeeding women

Keywords: interscalene block shoulder surgery local anesthesic respiratory function diaphragmatic dysfunction echography locoregional anesthesia
endoscopy-related phone consultation during the covid-19 outbreak

Conditions: Colon Polyp; Colon Disease; Reflux, Gastroesophageal; Varices, Esophageal

Summary: the aim of this study is to evaluate patient and consultant experiences with phone consultations for endoscopy-related outpatient appointments during the covid-19 outbreak.

telephone consultations as a method for telehealth do not provide visual cues and limit interpretation of visual signs such as visualization of skin lesions. however, the need of such feedback is almost non-existent for endoscopy-related consultations as their purpose is focused. the main foci of endoscopy-related outpatient clinics are two: 1 - inform and consent the patient for an endoscopic procedure that is to be done in the near future; 2 - explain the results of a recent procedure already performed and which has a copy provided to the patient. therefore, phone consultations might be a good fit for endoscopy-related outpatient clinics. the practicalities and indications for the use of phone consults has been described by van galen \& car (2018) and fit the above description. patients will be invited to participate only after the consultation have been finalised and all questions regarding the endoscopic procedure to be done/that was done have been clarified. patients and consultants will fill questionnaires to evaluate the phone consultation. the primary outcome will the the comparison of "failed to attend" (fta) occurrences compared to a similar period of the past year. secondary outcomes will be patients' and consultants' satisfaction with the phone consultation.

Eligibility criteria:
inclusion criteria: * patients booked for an outpatient consultation in the post-endoscopy clinic or advanced endoscopy clinic * consultation determined to be held over the phone as per preventive measures due to the covid-19 outbreak * age \> 18 years * ability to give informed consent exclusion criteria: * phone consultation done with a relative as per patient's preference or inability to talk over the phone * patient that is deemed as confused/not able to understand * unwilling/unable to participate in the post-consultation survey
duraseal exact spine sealant system post-approval study

Conditions: Dural Sealing

Summary: this is a non-randomized, post-approval study to further evaluate the rate of post-operative cerebral spinal fluid (csf) leaks in subjects who undergo a spinal procedure and receive duraseal exact spine sealant system.


Eligibility criteria:
inclusion criteria: * subject is 18 years of age or older * subject had a spinal procedure where a dural opening (either intentional or incidental) occurred and was treated with either: * duraseal™ exact spine sealant (duraseal™ sealant group only) or * any other method of sealing the dura with the exception of duraseal™ sealant -either spinal or cranial. (control group only) * subject, or authorized representative, has been informed of the nature of the study and has provided written informed consent approved by the appropriate institutional review board (irb) of the respective clinical site prior to the collection of study data. * prospective subjects: consent must be obtained within 24 hours of surgery stop time. * retrospective subjects (control group specific): irb approval may be granted to individual sites to waive requirement for informed consent. exclusion criteria: * the investigator determines that the subject will not be able to comply with the required follow-up visits (not required if subject is being enrolled retrospectively- control group only) * pregnant or breastfeeding females (as documented in the medical records; no testing beyond the site's standard of care is required)

Keywords: cerebrospinal fluid leaks dural opening dural sealing
noninvasive ventilation in als patients with mild respiratory involvement

Conditions: Amyotrophic Lateral Sclerosis

Summary: non-invasive ventilation or bipap®, which is a form of breathing support delivered through a facemask, is a successful treatment for the respiratory complications of amyotrophic lateral sclerosis (als). it has been shown to prolong survival, improve quality of life, and improve cognitive function. it is widely used among patients with als who have advanced breathing difficulties. it is not known whether there is benefit to using non-invasive ventilation earlier in the disease course. there is evidence that non-invasive ventilation may slow down the decline in breathing function. if this were true then it would make sense to start non-invasive ventilation use earlier than the current clinically accepted practices. the purpose of this study is to determine whether using non-invasive ventilation early in the course of disease can slow the decline in breathing function. patients remain in the study for 6 months and are asked to make 7 clinic visits during which time they will undergo pulmonary function tests and complete questionnaires.

this is a randomized, crossover trial for patient with als and mild respiratory involvement. patients with forced vital capacity above 60% of the predicted value can join. patients will be assigned to either start using non-invasive ventilation at night or continue their usual care. after three months, patients will switch over to the other treatment group. for example, a patient who was initially assigned to continue their usual care would begin using non-invasive ventilation after three months.

Eligibility criteria:
inclusion criteria: * probable or definite als by el escorial criteria * age \>17 years * fvc \>60 * minimal respiratory symptoms (no orthopnea or dyspnea at rest) * ability to provide informed consent exclusion criteria: * presence of another neurodegenerative disease * arterial co2 above 45 mmhg * o2 below 60 mmhg * coexisting chronic lung disease unrelated to als * presence of an unstable medical condition such as coronary artery disease, liver failure, renal failure or cancer in the 30 days preceding enrollment

Keywords: bipap lou gehrigs disease motor neuron disease respiratory muscles
sublingual misoprostol in decreasing blood loss prior to myomectomy

Conditions: Blood Loss in Myomectomy

Summary: the aim of the study is to compare the effectiveness of sublingual administered prostaglandin e1 synthetic analogue (misoprostol) 400 microgram versus placebo before myomectomy to decrease blood loss during and after the operation.


Eligibility criteria:
inclusion criteria: * patients presenting for abdominal myomectomy with documented uterine fibroids on pelvic imaging * age ≥ 18 years and ≤ 50 years * pre-operative hemoglobin \>8 g/dl * ability to understand and the willingness to sign a written informed consent. * admissible medical/surgical history * five or less symptomatic uterine myomas * all myomas are subserous or intramural. * uterine size less than 24 weeks pregnancy exclusion criteria: * patients who have had a prior abdominal myomectomy * post-menopausal women * patients with known bleeding/clotting disorders * patients with a history of gynecologic malignancy * hypertension. * cardiac and pulmonary diseases. * obesity (body mass index \> 30 kg/m2). * history of allergic reactions attributed to misoprostol * cases that will require intraoperative conversion of myomectomy to hysterectomy.
yliver as a test to early diagnose hcc

Conditions: Hepatocellular Carcinoma

Summary: liver cancer (hcc) is the second cause of death related to cancer worldwide, with about 750,000 deaths from this cause in 2012. although the early diagnosis of liver cancer increases the available treatment options, the methods currently used for screening are not sufficiently sensitive for this purpose. the investigators provide a high-performance and highly reliable in vitro platform that allows the identification and quantification of autoantibodies in serum for use as biomarkers of liver cancer, using an elisa test (yliver). the aim of the study is to demonstrate whether the yliver test can be used as a biomarker for the early diagnosis of hepatocellular carcinoma with a collection of samples from 58 patients diagnosed with hcc, 42 cirrhosis, 40 normal controls and the inclusion of 25-50 patients with chronic liver disease without cirrhosis.


Eligibility criteria:
inclusion criteria: easl clinical practice guidelines \& practice guidance by the american association for the study of liver diseases for diagnosis of hcc, liver cirrhosis, chronic hepatitis without cirrhosis exclusion criteria: * age under 18 years * very advanced disease (patient in a terminal state that is not indicated analytical determinations). * hepatic encephalopathy that prevents the correct understanding of informed consent. * refusal to carry out the determination or to sign the informed consent. * patients affected by another neoplastic disease

Keywords: hepatocellular carcinoma tumor associated antigen early diagnosis autoantibodies alpha fetoprotein
accuracy of self-estimation of blood alcohol concentration compared to object values

Conditions: Alcohol Intoxication

Summary: this will be a prospective survey study. the participants will all be volunteers of legal drinking age. each participant will consume one alcoholic beverage (beer) at a time and then will be asked to verbally estimate their current blood alcohol concentration and if the subject feels they are able to drive. at that time, their bac level will be measured objectively using a breath alcohol test (bat) device. the participant will not be told their objective value. this will continue with a verbal estimate and actual bat reading after every drink until the participant reaches a minimum bac of 0.10. at this time, participants will continue to be monitored until their bac falls to 0.08 and they are clinically sober. as their blood alcohol level decreases, the investigators will ask the participant to estimate their level every hour along with an actual reading until reaching 0.08. statistical analyses will be used to determine how accurate self estimation is in regards to blood alcohol content.


Eligibility criteria:
inclusion criteria: * over the legal age (21years old) to drink alcohol. exclusion criteria: * volunteers will be excluded from the study if they suffer from any of the following conditions: alcoholism, diabetes, kidney/bladder stones, kidney disease, liver disease, stomach ulcer, organ transplant patients, dialysis patients, and patients with alcohol allergies.
study of the emergence of sensory self-awareness in premature newborns using the rooting reflex

Conditions: Premature; Development, Child; Rooting Reflex

Summary: the main objective is to demonstrate the presence of the rooting reflex in premature and the emergence of sensory self-awareness in premature by showing a difference in the response of the rooting reflex to external tactile stimulation and to facilitated tactile self-stimulation during quiet wakefulness. the main hypothesis is to confirm the tactile skills of the very premature newborn in exploring the rooting reflex and then to evaluate the emergence of sensory self-awareness. the investigators assume a difference in response in favour of a greater response of the newborn to external tactile stimulation compared to facilitated self-stimulation in favour of the distinction between self and non-self showing the emergence of a sensory awareness of self in the preterm newborn.

touch is the first sense to develop in foetal life. children born prematurely have early tactile skills, in particular the ability to discriminate and learn. these tactile skills can be expressed through the newborn's reflexes. the sensory exploration that takes place when reflexes are manifested can be the basis for tactile learning and, in particular, for the development of the baby's awareness of his own body, with discrimination of the self. as touch plays an essential role in the child's perceptual-cognitive development, studying the tactile skills of premature infants is an ideal approach for a better understanding of the development of primitive sensory awareness. the main hypothesis is to confirm the tactile skills of the very premature newborn in exploring the rooting reflex and then to evaluate the emergence of sensory self-awareness, by comparing the response of the rooting reflex between facilitated self-stimulation and external stimulation. the investigators assume a difference in response in favour of a greater response of the newborn to external tactile stimulation compared to facilitated self-stimulation in favour of the distinction between self and non-self showing the emergence of a sensory awareness of self in the preterm newborn. the study of the specific sensory of the premature newborn is part of the continuum of developmental care, and is part of an approach to improving the care delivered in neonatology with the aim of encouraging the best neurological development.

Eligibility criteria:
inclusion criteria: * children born prematurely between 28 and 37 weeks of amenorrhoea, aged at least 3 days. exclusion criteria: premature newborns with : * respiratory assistance (invasive or non-invasive ventilation) * malformative syndrome * a genetic syndrome * neurological damage such as stage iii or iv intraventricular haemorrhage or periventricular leukomalacia, * sedative treatment: morphine, clonidine * aminergic treatment * acute pathology: shock, sepsis, acute cardiac failure, acute respiratory failure, etc.

Keywords: rooting reflex sensory self-awareness tactile sensory premature newborn development care
enteral feeding in infants with duct dependant lesions.

Conditions: Duct Dependent Lesions; Necrotising Enterocolitis; Death; Growth

Summary: this is a multicenter randomised controlled trial to assess whether standardised enteral feeding in newborns with duct dependenty congenital heart disease decreases the risk of necrotising enterocolitis (nec). the investigators plan to include a total 384 infants. the study will be carried out in three level iii hospitals in poland. the primary end will be nec and/or death. secondary end points include weight gain, hospital length of stay, time required to reach full feeding.


Eligibility criteria:
inclusion criteria: 1. duct dependent congenital heart disease 2. term infants 3. parental/legal guardian consent exclusion criteria: 1. potential contradictions to early central feeding 2. feeding intolerance 3. hemodynamic instability 4. death 5. \> 50% formula based enteral feeding 6. birth weight less than 2500g

Keywords: congenital heart disease nutrition growth newborn
stress and coping, resilience, and compassion fatigue of front-line nurses during covid-19 pandemic

Conditions: COVID-19 Pandemic; Stressor, Psychological; Mental Health Issue

Summary: this is a cross-sectional research. the investigators plan to recruit about 250 front-line nurses who provided direct care to covid-19 confirmed cases in a medical center in taiwan. online querstionnaires are used to collect the data. the relationship between variables such as stressors related to covid-19, coping status, resilience, and compassion fatigue of participants will be analysis to provide the direction of nurses' mental health-related interventions.

this project aims to identify the prevalence of compassion fatigue and the coping strategies for the nurses who work on the frontline of healthcare and are responsible for caring for patients with covid-19 in taiwan. the investigators planed to carry a cross-sectional study by a reliable and valid online questionnaire to explore the stressors related to covid-19, coping status, resilience, and compassion fatigue of nurses who had the experience of caring for the covid-19 confirmed cases in a medical center during the community outbreak in taiwan from may 2021. online questionnaires are used to collect the data. about two hundred and fifty nurses will be recruited, and the data will be analyzed by descriptive statistics, correlation statistics and hayes's process model 6. it is expected that the research results can understand the current status and relationship of compassion fatigue, resilience and the adaptability of clinical nurses who are caring for the covid-19 confirmed cases. the results can be contributed to develop the direction of nurses' mental health-related interventions during pandemic of emerging contagious disease.

Eligibility criteria:
inclusion criteria: * above/include 20-year-old. * those who can operate mobile communication software or computers and can fill in online questionnaires. * clinical nurses who had provided nursing care for covid-19 confirmed cases from may 2021. exclusion criteria: * those who did not provide nursing care for covid-19 confirmed cases.

Keywords: covid-19 front-line nurses compassion fatigue burnout stress coping resilience
isthmocele after two different sutures in cesarean section

Conditions: Cesarean Scar Defect

Summary: cesarean delivery (cd) rates are rising globally. about 30% of women delivered by cd in 2015 only in the usa. this increasing cd rate has stimulated an interest in the potential short- and long-term morbidity of cd scars. in more than 50% of women with history of cd, a uterine scar defect, also called a "isthmocele," defined as a disruption of the myometrium in the cd uterine scar, can be observed when examined by gel instillation sonohysterography 6-12 months after the cd. uterine scar defects detected on ultrasound have been associated with prolonged menstrual bleeding and postmenstrual spotting, as well as with an increased risk of several obstetrical complications in subsequent pregnancies, including uterine dehiscence and/or rupture, scar pregnancy and placenta previa and accreta. another screening method associated with uterine scar rupture in women with prior cd is ultrasonographic measurement of the thickness of the lower uterine segment, as pioneered by rozenberg et al. in 1996. a meta-analysis by kok et al. supports the use of the residual myometrial thickness (rmt) for predicting uterine rupture during vaginal birth after cesarean. uterine scar defects have been associated with lower rmt. a growing body of evidence suggests that the surgical technique for uterine closure influences uterine scar healing and the rmt, but there is still no consensus about optimal uterine closure and type of suture. it is imperative to have evidence-based guidelines for each surgical step before recommending one technique over another. the aim of our trial is to evaluate the incidence of cesarean scar defect according to type of suture at the time of cesarean


Eligibility criteria:
inclusion criteria: * pregnant women with singleton gestations * between ≥37 and ≤42 gestational age * \>18 \<45 years * undergoing primary or secondary elective or urgent cesarean delivery exclusion criteria: * multiple gestations * preterm cesarean * 2 or more prior cesarean deliveries * uterine malformations * prior myomectomy * placenta accreta/previa