Kornimate/medical-research-clean huggingface dataset:
effects of individualized peep guided by driving pressure on postoperative atelectasis in patients with morbid obesity

Conditions: Pulmonary Atelectasis; Obesity, Morbid

Summary: atelectasis is a common complication in patients undergoing surgery under general anesthesia, particularly in obese patients. postoperative atelectasis could last for more than 24h and contribute to a variety of other complications, including hypoxemia and pneumonia. we plan to conduct a single-center, randomized controlled trial in patients undergoing bariatric surgery to test the hypothesis that driving pressure guided peep could reduce the postoperative atelectasis.

positive end-expiratory pressure (peep) is a strategy that helps to keep alveoli open during surgery and to prevent postoperative atelectasis. a fixed peep without considering the respiratory mechanics in individual patients, however, is not optimal. individualized peep therefore has been increasingly studied, and has been shown to improve oxygenation in both nonobese and obese patients. studies have shown that the occurrence and prognosis of ppcs are significantly associated with high driving pressure (dp), but not with vt and peep. driving pressure-guided individualized peep is expected to be a novel perioperative lung protection strategy. consequently, the main aim of this study is to investigate the effect of a driving pressure-guided individualized peep ventilation strategy on postoperative pulmonary atelectasis in morbidly obese patients undergoing bariatric surgery.

Eligibility criteria:
inclusion criteria: * age 18 to 60 years old; * body mass index (bmi) ≥ 40 kg/m2; * asa classification i to iii; * signing the informed consent form for this clinical study; exclusion criteria: * respiratory infection within 4 weeks; severe respiratory system diseases; history of pulmonary and/or thoracic surgery; neuromuscular dysfunction; * serious cardiac, renal or haematopoietic diseases; * contraindications to peep；

Keywords: individual positive end-expiratory pressure driving pressure ventilator-induced lung injury
cough among hypertensive patients treated with telmisartan, who had to stop previous ace-i treatment due to cough in slovakia

Conditions: Hypertension

Summary: in the light of ontarget and transcend studies results, it would be interesting to investigate the real-life telmisartan treatment tolerability. it is well known and accepted that the real-life setting is much more adequate to reflect the antihypertensive and safety properties of the drug in comparison to the organized and scheduled setting of the clinical trial. because there are not much data on the cough in relation to telmisartan, therefore it would we worth to observe the cough frequency and general treatment tolerance in patients treated with telmisartan, who had to stop their previous ace-i treatment due to cough.


Eligibility criteria:
inclusion criteria: * hypertension * age \> 18 * ace-i related cough exclusion criteria: * current treatment with telmisartan * cholestatic disorders and severe hepatic failure * allergy to telmisartan * pregnancy and lactation period

Keywords: cough telmisartan bradykinin tolerability
use of hyperpolarized 129xe mr lung imaging in adults for calibration

Conditions: Respiratory Disorders

Summary: the goal of this study is to evaluate the usefulness of hyperpolarized (hp) 129xe (xenon) gas mri for regional assessment of lung function in a normal population of adults for the purposes of obtaining optimal images through mri.

hyperpolarized 129xe will be produced, by trained staff, using a polarizer housed at cincinnati children's hospital medical center. individual imaging sessions will be done on a single day and will involve administration of (maximum) 1 liter doses for up to four mri scans. subject will inhale hyperpolarized xenon gas and hold breath for up to 16 seconds during the mri scans. in addition to 129 xe mri, a series of anatomical conventional proton mr images may also be collected. follow up will be done one day and 30 days from the mri date.

Eligibility criteria:
inclusion criteria: * adults ages 18 years and older * participant must be able to hold their breath for up to 16 seconds exclusion criteria: * history of heart defect * pregnancy or positive pregnancy test * history of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month. * symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week. * baseline oximetry at mri visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula. * participant is claustrophobic and unable to tolerate the imaging. * standard mri exclusions (metal, implants).

Keywords: respiratory
prospective determination of covid-19 infection rate in a chemotherapy unit in mexico.

Conditions: Covid19; Cancer; Tumor

Summary: cancer patients are considered vulnerable to covid-19 infection. during the pandemic, cancer patients may need to continue their regular treatment of chemotherapy and / or radiotherapy and therefore must visit a hospital unit. as such, they may be at risk for sars-cov-2 infection by means of close contact to other patients and health care workers. hospitals may implement policies to identify symptomatic subjects and limit their access to the chemotherapy / radiotherapy unit. however, asymptomatic covid-19 positive patients may escape these filters and potentially be contagious to other patients and their health-related workers that care for other several patients. therefore, there is a real risk of an outbreak that affects a particularly fragile patient population. patients and their doctors need to know what is the risk associated to visiting a chemotherapy unit in order to decide if the risk outweighs the benefits of cancer treatment in their particular case. to date, this risk is unknown. the study will test patients and health care workers for covid-19 infection during the peak of the pandemic in a chemotherapy unit in mexico in order to determine this risk.

in this is prospective cohort, patients with solid tumors and healthcare workers of the chemotherapy and radiotherapy unit at our center will be followed with a daily digital survey and optionally with biweekly pcr tests for sars-cov-2. people with symptoms and / or with a positive pcr test for sars-cov-2 will be notified and recommendations according to clinical state will be emitted. hypothesis: covid-19 infection rate among patients with solid tumors treated with chemotherapy and / or radiotherapy will be less than 5% during the pandemic period.

Eligibility criteria:
inclusion criteria: * patients with solid tumors receiving active oncological treatment (chemotherapy, or radiotherapy or biologic therapy) at our center. * age: no limit * gender: men and women. * health-related worker treating patients with solid tumors at the chemotherapy and radiotherapy unit at our center. * people who sign an informed consent. exclusion criteria: * patients with an hematologic cancer. * patients with cancer under surveillance or without active oncological treatment, or receiving treatment in another center.

Keywords: covid19 cancer
arterial catheter to monitor glycemia

Conditions: Critical Illness; Hyperglycemia

Summary: the technique of blood samples extraction from the radial artery through an arterial catheter with a 3-way stopcock and automated washing with valve of fast flow is better than the one carried out through a fixed reusable arterial blood sample syringe and its manual washing because it shows a minor incidence of the complications originated from technical manipulation as infection, pseudo-aneurysm, ischemia or thrombosis of radial artery or obstruction of the catheter. the purpose of this study is to evaluate the efficacy, in terms of adverse effects, of blood samples obtention using an arterial catheter with needless connector closed system or an arterial catheter with an arterial blood sample syringe. also a second purpose is to compare once a day (at the same time) the values of glycose blood levels between bedside glucometer determination of arterial catheter extraction and capillar puncture, and lab determination of glycose from venous puncture, in order to determinate fluctuation in glycose levels due to peripherical hypoperfusion or to vasoactive drugs received by these in-intensive care unit patients.


Eligibility criteria:
inclusion criteria: * admission in intensive care unit * insertion of a radial artery catheter for the invasive monitoring of haemodynamic pressure for a maximum of 5 days * need of insulin therapy by an intravenous continuous perfusion exclusion criteria: * patients who do not accept to participate (or their relatives do not accept) * patients with a medical limitation of effort therapy * patients with flotrac sensor from edwards lifesciences which does not allow to add a supplementary 3-way stopcock

Keywords: critical illness hyperglycemia catheters, indwelling intensive care unit
safety and efficacy of levamisole combined with cyclosporine a in patients with classic paroxysmal nocturnal hemoglobinuria

Conditions: Paroxysmal Nocturnal Hemoglobinuria; Hemoglobinuria; Hemoglobinuria, Paroxysmal; Proteinuria; Urination Disorders; Thrombosis; Bone Marrow Failure; Aplastic Anemia,; Anemia, Hemolytic

Summary: paroxysmal nocturnal hemoglobinuria is an acquired chronic hemolytic anemia,this study is designed to evaluate the safety and efficacy of levamisole combined with cyclosporine a in patients with classic paroxysmal nocturnal hemoglobinuria.

paroxysmal nocturnal hemoglobinuria (pnh) is an acquired clonal disorder of the hematopoietic stem cell characterized by intravascular hemolysis, hemoglobinuria, anemia, and thrombosis, patients may be at high risk of thrombosis and may develop bone marrow failure or aplastic anemia, with low white blood cell and platelet counts,because the manifestation and pathologic processes are complicate,the treatment is very difficult,this study is designed to evaluate the safety and efficacy of levamisole combined with cyclosporine a in patients with classic paroxysmal nocturnal hemoglobinuria

Eligibility criteria:
inclusion criteria: 1. clinical and biochemical signs of classic paroxysmal nocturnal hemoglobinuria 2. diagnosis confirmed by ham's test or flow cytometry patients have any flow cytometry data 3. patient should complete levamisole study for at least half a year exclusion criteria: 1. active infection which requires antibiotic treatment 2. pregnant or lactating women 3. epilepsy and mental illness 4. kidney and liver function abnormal 5. patient who terminate ealy from levamisole study

Keywords: paroxysmal nocturnal hemoglobinuria anemia hematologic diseases bone marrow failure immunologic factors physiological effects of drugs levamisole cyclosporine a
the effect of motilin on the frequency and amount of food intake

Conditions: Healthy; Obesity

Summary: in this study, the investigators aimed at evaluating the role of motilin in the regulation of food intake. motilin, a gastrointestinal hormone, is a hunger signal in healthy volunteers and is significantly increased in obese patients. its role in food intake regulation might contribute to the pathogenesis of obesity.


Eligibility criteria:
inclusion criteria: * bmi \< 30 kg/m² for lean volunteers * bmi \> 30 kg/m² for obese volunteers * subject is capable and willing to give informed consent * female volunteers of child bearing potential must use oral, injected or implanted hormonal methods of contraception exclusion criteria: * female volunteer is pregnant or breastfeeding * gi diseases, major abdominal surgery * major psychiatric illnesses * volunteers that use drugs affecting the gi tract or the central nervous system * volunteers suffering from endocrine diseases such as diabetes, cushing's disease, addison's disease, hypothalamic tumor * volunteers that have undergone surgical procedure for weight loss

Keywords: motilin erythromycin food intake
methadone maintenance for prisoners

Conditions: Heroin Addiction

Summary: this five-year study examines the benefits of methadone maintenance treatment initiated in prison and continued in the community to male offenders who were previously, but not currently, heroin-dependent. it is anticipated that such prisoners will have more favorable outcomes in the year following release with regard to drug abuse, crime, and hiv risk behavior than either prisoners who receive counseling only or begin initiation of methadone maintenance in the community

most prisoners with histories of pre-incarceration heroin addiction do not receive treatment while incarcerated or upon release. effective treatment for such prisoners is urgently needed because rapid relapse typically follows release. relapse is associated with increased risk for hiv, overdose death, criminal activity, and reincarceration. other than three studies of methadone maintenance with short-term jail inmates, the only study of longer-term inmates who were previously, but not currently, heroin-dependent was the investigator's pilot study with pre-release inmates. based on that pilot study, which found that initiating maintenance treatment is feasible and facilitates post-release treatment entry, the present study provides a more rigorous examination of this unique treatment approach.

Eligibility criteria:
inclusion criteria: * heroin dependence in the year prior to current incarceration * 3-6 months left to serve in prison-male pre-release inmate suitability for methadone maintenance as determined by medical evaluation * willingness to enroll in methadone maintenance * having a baltimore address exclusion criteria: * pending parole hearing * pending charges * kidney failure * liver failure
internet self-management program with telephone support for adolescents with arthritis

Conditions: Juvenile Idiopathic Arthritis

Summary: this study will evaluate the feasibility of "teens taking charge: managing arthritis on-line" intervention that will help adolescents with arthritis to better manage their disease and improve their health-related quality of life (hrql).

this feasibility study will (1) assess adolescents' willingness to be randomized; (2) pilot the intervention, attention control strategies (e.g., adolescents' 'own best efforts' at managing arthritis), and outcome measures; (3) determine adolescents' perceptions regarding acceptability of the web-based intervention; and (4) obtain estimates of treatment effects in primary (hrql) and secondary (knowledge, coping, self-efficacy, stress, treatment adherence, pain) outcome measures to inform the calculation of appropriate sample size for the future rct. we hypothesize that adolescents with jia in the web-based intervention will demonstrate: (a) improved hrql; (b) increased disease-specific knowledge; (c) improved coping, self-efficacy, and adherence to prescribed management; and (d) decreased pain and stress compared to adolescents in the attention control group

Eligibility criteria:
inclusion criteria: * adolescents 12 to 18 years * diagnosed with jia, * able to speak and read english or french * able to complete baseline online outcome measures. exclusion criteria: * cognitive impairment * major co-morbid illnesses (medical or psychiatric) which may impact their ability to understand and use the web-based program.

Keywords: teens taking charge managing arthritis online juvenile idiopathic arthritis internet self-management
rifaximin 3 times/day (tid) for non-constipation irritable bowel syndrome (ibs)

Conditions: Non-Constipation Irritable Bowel Syndrome

Summary: to evaluate the efficacy of a 14-day course of rifaximin given 3 times a day vs. placebo in providing adequate relief of ibs symptoms.


Eligibility criteria:
inclusion criteria: * confirmed ibs diagnosis per rome ii for diagnosis of ibs. * colonoscopy within 2 years as part of ibs diagnostic evaluation. * has active symptoms of non-constipation ibs at baseline as measured by average daily scores for abdominal pain/discomfort, bloating, and stool consistency. exclusion criteria: * symptoms of constipation. * history of other gastrointestinal diseases. * type 1 or 2 diabetes. * lactose intolerance not controlled by lactose-free diet.

Keywords: ibs abdominal pain bloating diarrhea rifaximin
study the safety and efficacy of bone marrow derived autologous cells for the treatment of optic nerve disease

Conditions: Optic Atrophy

Summary: this is a single arm, single centre trial to check the safety and efficacy of bone marrow derived autologous mono nuclear cell(100 millions per dose )clinical trial to be conducted for 36 months in patients with optic nerve diseases.

optic nerve diseases: conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component of the central nervous system. damage to optic nerve fibres may occur at or near their origin in the retina, at the optic disk, or in the nerve, optic chiasm, optic tract, or lateral geniculate nuclei. clinical manifestations may include decreased visual acuity and contrast sensitivity, impaired color vision, and an afferent papillary defect. primary out put of clinical study is to measures improvement in visual loss and improvement in idiopathic intra cranial.this is a single arm, single centre trial to check the safety and efficacy of bone marrow derived autologous mono nuclear cell(100 millions per dose )clinical trial to be conducted for 36 months .

Eligibility criteria:
inclusion criteria: * patient should suffer from optic nerve diseases like diabetic retinopathy, retinal pigmentation * age in between 18 to 50 * willingness to undergo bone marrow derived autologous cell therapy. * ability to comprehend the explained protocol and thereafter give an informed consent as well as sign the require informed consent form(icf) for the study. * a ability and willingness to regular visit to hospital for protocol and follow up. exclusion criteria: * patients with pre - existing or current systemic disease such as lung , liver ( exception; history of uncomplicated hepatitis a),gastrointestinal, cardiac , immunodeficiency,(including hiv) or laboratory investigation that could cause a neurological defect including syphilis, clinically relevant polyneuropathy) etc. * history of life threatening allergic or immune- mediated reaction * haemodynamically unstable.

Keywords: optic atrophy,stem cell therapy
analysis of different postoperative analgesia strategies following scoliosis surgery

Conditions: Idiopathic Scoliosis

Summary: idiopathic scoliosis surgery is a major surgery, causing significant post-operative pain which can have a significant impact, both for the patient and for society. different analgesic strategies have emerged in recent years, within the framework of multimodal analgesia including systemic analgesics, but also axial or peripheral loco-regional anesthesia (lra). these techniques are integrated into the recommendations of learned societies, aimed at optimizing the post-operative rehabilitation of patients. if intrathecal morphine injection (itm) and spinal erector block (espb) have already shown their effectiveness in reducing postoperative pain, the combination of these techniques can have a real benefit in major spinal surgery. , and has not yet been studied.


Eligibility criteria:
inclusion criteria: * patient aged \> 15 years * patient who underwent scoliosis surgery by the spine surgery team at hautepierre hospital between january 1, 2020 and june 30, 2023 * patient or holder of parental authority not opposing the reuse of their data for scientific research purposes exclusion criteria: * oral or written refusal of the patient (or the holder of parental authority) to reuse their data for scientific research purposes * history of spinal surgery * level 3 analgesics at home * protection of justice, titular or curatorship

Keywords: idiopathic scoliosis
repetitive transcranial magnetic stimulation associated with physical therapy to reduce upper limb spasticity in post stroke patients

Conditions: Chronic Stroke

Summary: in this study, it is being investigated if the association between high frequency repetitive transcranial magnetic stimulation associated with motor physical therapy reduces spasticity, increases upper limb motor function, and quality of life of post-chronic stroke patients than motor physical therapy alone. for this purpose, patients included will be submitted to ten sessions with active or sham hf-rtms followed by a protocol of physical therapy.


Eligibility criteria:
inclusion criteria: * age 30 to 75 years; * both sexes; * with diagnosis of ischemic or hemorrhagic stroke proven by means of computed tomography or magnetic resonance imaging; * spasticity grade will be assessed using the ashworth modified scale (bohannon \& smith, 1987), with score +1, 2 or 3 for the wrist flexors of the affected upper limb; * with absence of cognitive deficit verified by the folstein mini mental state examination (score ≥ 20) modified for the brazilian population (brucki et al., 2003) exclusion criteria: * contraindications to and emt (rossini et al., 2015) * clinical evidence of multiple brain lesions * trauma-orthopedic injury that limits the range of motion of the upper limb * presence of visual and / or communication deficit * involvement of other interventions focused on reducing spasticity * modification of medications in the last 30 days.

Keywords: repetitive transcranial magnetic stimulation, physiotherapy, stroke, spasticity
efficacy and safety of utapine vs. seroquel in patients with bipolar mania

Conditions: Bipolar, Mania; Utapine; Seroquel

Summary: the goal of this research is to evaluate the safety as well as effectiveness of utapine and seroquel in bipolar i disorder patients.

utapine and serquel belong to anti-bipolar medication family, both are approved by doh (department of health, taiwan), both has same ingredient but different manufacture. from clinical trial reports, both has excellent effectiveness and safety. the goal of this research is to evaluate the safety as well as effectiveness of utapine and seroquel in bipolar i disorder patients for different ingredient and different manufacture.

Eligibility criteria:
inclusion criteria: 1. male or female age 18-65 years with diagnosis of bipolar i disorder who will be included by dsm-iv criteria made at least one manic or mixepisode record before study entry. 2. having a minimum score of 20 on the young mania rating scale (ymrs), plus a score of at least 4 on two of the core ymrs items of irritability,speech, content, and disruptive/aggressive behavior. 3. at least 4 will be on the severity of illness item of the clinical global impressionsnbipolar(cginbp)assessment tool. 4. patient with good compliance to study medicine and adherence to study protocol. exclusion criteria: 1. had received treatment with clozapine within 28 days of the start of the trial. 2. had been hospitalised for 3 weeks or longer for the index manic episode. 3. dsm-iv criteria for rapid cycling or a current mixed episode. 4. intolerance or lack of response to quetiapine or clozapine before this trial be diagnosed by investigator. 5. neurodegenerative disease eg:parkinson desease、huntington disease、pick's disease. 6. medicine or drugs which can change mental condition be judged by investigator. 7. ekg abnormality 8. drug or alcohol abuser

Keywords: bipolar, mania utapine seroquel