Kornimate/medical-research-clean huggingface dataset:
laser treatment of toenail onychomycosis with a 1064 nm nd:yag-laser

Conditions: Onychomycosis of Toenail

Summary: this study aims to assess if laser treatment can cure fungal infection in toenails. nail clippings from eligible subjects were obtained and randomised into two groups. all nail clippings were treated once with a 1064 nm nd:yag-laser. before and after treatment, nail clippings were tested for fungal infection by microscopy and by culture.

this study was carried out as a randomised controlled trial (rct) including two treatment groups subjected to two different laser treatments. a 1064 nm nd:yag-laser (candela medical, ellipse nordlys (nd:yag 1064), usa) was used for all treatments. potential subjects were recruited from general practitioners and skin clinics in north jutland from august 24th, 2021, through december 2021. all interventions and mycological tests for each subject were performed over the course of one day. after subjects were included, toenails with a clinical suspicion of onychomycosis (om) were tested for fungal infection by culture and microscopy. at the same time, nail clippings from said toenails were obtained and randomised into one of two treatment groups, i.e., group a and group b. the nail clippings were then treated with a 1064 nm nd:yag-laser with laser settings as specified by the treatment groups. all nail clippings were treated only once. immediately after treatment, nail clippings were again tested for fungal infection by culture and microscopy.

Eligibility criteria:
inclusion criteria: * adult patient (\>18 years) * clinical suspicion of fungal infection in at least one toenail * signed informed consent * sufficient nail material to perform two cultures and one nail clipping exclusion criteria: * administration of oral antifungal medication in the last 12 months or topical antifungal medication in the last month * diabetes mellitus with associated peripheral artery disease (pad) or neuropathy * under the influence of alcohol or illegal narcotics * unable to understand written and spoken danish
biological meshes in infected fields: a randomized controlled trial

Conditions: Ventral Hernia

Summary: the simbiose trial is a large multicenter phase iii prospective randomized controlled single blinded trial comparing the use of biological mesh versus traditional wound care without biological mesh in patients with an infected incisional ventral hernia. the primary endpoint is 6-month infectious and/or wound morbidity. secondary endpoints are wound infection rate at 45 days, 3 months and 1 year, recurrent hernia rates at 1, 2 and 3 years, postoperative pain, quality of life, time to healing, need for wound reoperation, impact of the cross-linked mesh structure, and medico-economic evaluation. one hundred patients need to be included.

comparison between standard wound care and the use of biological meshes in infected fields

Eligibility criteria:
inclusion criteria: * wound infection related to a synthetic non-absorbable mesh for at least 15 days duration * incisional abdominal hernia with an abcess or fistula, without the presence of a synthetic non-absorbable mesh * incisional abdominal hernias smaller than 20 centimeter in the 2 largest diameters * incisional abdominal hernias requiring a surgical procedure * incisional abdominal hernias amenable to repair with a single biological mesh * age over 18 years exclusion criteria: * non-infected incisional abdominal hernia * history of biological mesh placement * incisional abdominal hernia in contaminated, but non infected field (stoma presence, violation of gastrointestinal tract) * incisional abdominal hernia larger than 20 x 20 cm * bmi ≥ 40 kg/m2 * asa score 4 and 5 * immunosuppression (including steroid and cytotoxic therapy) * chronic disease such as cirrhosis, renal insufficiency with renal dialysis, malignant disease, known collagen disorder * life expectancy under than 36 months * allergy to one of the biological mesh components * pregnancy or breastfeeding

Keywords: incisional ventral hernia infected field biological mesh
vertebral fat quantitative mri as a marker of bone fragility in multiple myeloma (myelomefragiquanti)

Conditions: Multiple Myeloma; Vertebral Fracture

Summary: multiple myeloma is a disease that causes increased bone fragility which is often revealed or complicated by vertebral fractures. invasion of bone marrow by tumor plasma cells leads to bone destruction and reduced fat fraction. the main objective is to assess the correlation between vertebral bone marrow fat fraction and bone fragility represented by a severity score of vertebral fractures. the secondary objective is to assess the correlation with clinical and biological prognostic factors and scores..

patients treated with vertebroplasty will be included during the period of the study, retrospectively or prospectively. mains collected data are represented by : * bone marrow fat fraction determined by mri * severity score for vertebral fractures * clinical prognostic factors * biological prognostic factors * clinico-biological scores descriptive statistics and correlation analyses will be performed between the measured parameters.

Eligibility criteria:
inclusion criteria: * patients followed for multiple myelomas in the lariboisière/saint-louis/fernand-widal hospital group * vertebral fractures treated by vertebroplasty from january 2017 to december 2021 * recent clinical and biological data available at the time of imaging and fracture events exclusion criteria: * factors modifying the bone marrow fat fraction (extensive radiotherapy) * lack of recent clinical or biological data compared to imaging examinations

Keywords: bone marrow fat bone fragility fat quantification
prevalence and clinical implications of hpv infection in male ibd patients

Conditions: HPV Infection; Dysplasia Anus; Oral Cavity Disease

Summary: the study aims at describing the prevalence of human papillomavirus (hpv) infection in anal and oral samples of men with inflammatory bowel disease (ibd) and detecting risk factors for the infection.

male ibd patients attending the ibd clinic of hospital de la santa creu i sant pau will be screened for eligibility. informed consent will be obtained from all eligible patients. an anal and oral swab will be performed on all patients to look for hpv infection (hpv dna test) and cytologic alterations. patients will be inspected to rule out the presence of hpv-related lesions. moreover, a self-administered questionnaire will be completed by all enrolled patients. information regarding ibd characteristics and treatment will be obtained. according to local practice, patients with anal or oral squamous intraepithelial lesions (asil) will be referred to a colorectal surgeon for further recommendations or treatment.

Eligibility criteria:
inclusion criteria: * diagnosed crohn's disease or ulcerative colitis (at least 3 months before enrollment) * male * age from 18 to 79 years exclusion criteria: * unclassified inflammatory bowel disease * diarrhea (\> 3 bowel movements/day) with rectal bleeding at enrollment * prior full proctectomy * inability to collect the biological samples * inability to complete the questionnaire * refusal to sign the informed consent

Keywords: hpv, oral swab, anal swab
health-data register studies of risk and outcomes in cardiac surgery

Conditions: Cardiovascular Diseases; Kidney Diseases; Depression; Diabetes Mellitus

Summary: the overall project aim is to study risk and outcomes following cardiac surgery by cross-linking high-quality national swedish health-data registers for population-based investigations of individual level clinically relevant patient data.

the purpose of this research project is to study risks and outcomes in patients who underwent cardiac surgery. we aim to establish a fundament for the conduct of nationwide population-based studies by linking patient-level data from the swedish heart surgery register (swedeheart), the national patient register, the cause of death register, the national diabetes register, the swedish renal registry, the prescribed drug register, and the 2nd version of the swedish-danish scandinavian donations and transfusions database. cross-linking patient-level data is possible through the personal identity number assigned to every individual who has resided in sweden on a permanent basis. the swedish personal identity number is the unique identifier in all national registers. specifically, we aim: 1. to assess the importance of chronic kidney disease for prognosis after cabg. 2. to assess the consequences of acute kidney injury following cabg. 3. to analyze the prognosis in patients with depression prior to cabg. 4. to study risks and benefits of blood transfusions in cardiac surgery. 5. to study the risks associated with diabetes mellitus in cardiac surgery with special reference to type of diabetes (type 1 and type 2) and glycaemic control and duration of disease. 6. to investigate the long-term impact of different surgical strategies (e.g. use of multiple arterial grafts or non-use of cardio-pulmonary bypass) during cabg. 7. to analyze prognosis in relevant sub-populations undergoing cabg (e.g. patients 50 years or younger, possible differences between men and women, and patients with heart failure with preserved vs. reduced ejection fraction). 8. to investigate survival and morbidity in patients between 50 and 69 years undergoing aortic valve replacement with particular reference to prosthesis type (mechanical vs. biological). 9. to analyze the association between socioeconomic factors and prognosis in patients undergoing cardiac surgery. 10. to investigate factors related to durability of bioprosthetic aortic heart valves.

Eligibility criteria:
inclusion criteria: all adult patients who underwent cardiac surgery in sweden during the study period exclusion criteria: -

Keywords: cardiac surgery epidemiologic methods blood transfusions
diagnostic biomarkers for adult hemophagocytic lymphohistiocytosis in critically ill patients (hemicu)

Conditions: Hemophagocytic Lymphohistiocytosis

Summary: hemophagocytic lymphohistiocytosis in adults (hlh) is at 68% mortality whereas 78% of all cases remain undiagnosed though therapies are available which clearly reduce mortality. the investigators aim to systematically investigate this life-threatening hyperinflammatory syndrome in intensive care units (icu) in order to detect biomarkers that are highly sensitive and highly specific for hlh in icu compared to patients with sepsis.

the investigators will draw blood samples of 100 patients at the time of diagnosis (each 50 with suspected or diagnosed hlh/sepsis) to determine a cytokine panel (c reactive protein (crp), procalcitonin (pct), interleukin (il) 1β, il-6, il-8, il-10, il-18, il-33, tumor necrosis factor (tnf) α, interferon (ifn) ɣ, soluble il-2 receptor (sil-2r), the ebv and cmv viral loads, human immunodeficiency virus (hiv) antibodies and -antigen, perforin, fibrinogen, triglycerides, bilirubin, lactate dehydrogenase, liver transaminases, sodium, serum albumin, electrophoresis, glycosylated ferritin, the micrornas mir-205-5p, mir-194-5p and mir-30c-5p, perforin, cd107a and high immune status (differential blood count, t cells, b cells, nk cells, t helper cells, cytotoxic t cells, cd4 / cd8 ratio, hla-dr of cd8 +, cd11a of cd8, cd57 of cd8, cd28 of cd8 +, hla-dr of monocytes, cd56bright and cd69 of nk cells). the results of this study serve the development of new clinical concepts in order to safely diagnose hlh at an early stage, to distinguish from sepsis and to reduce the fatal consequences.

Eligibility criteria:
inclusion criteria: * male or female critically ill patients * at least 18 years old * suspected or diagnosed hlh exclusion criteria: * female patients: pregnancy * female patients: breastfeeding

Keywords: hemophagocytic lymphohistiocytosis (hlh) hemophagocytic syndrome (hps) critically ill intensive care unit (icu)
predicting renal injury in patient after hip fracture surgery

Conditions: Acute Kidney Injury

Summary: to determine whether maldi, a type of mass-spectometry, can use protein pattern detection within urine to predict postoperative (after an operation) kidney damage in adults who have undergone emergency hip fracture surgery?

the pre-renal study is a prognostic accuracy study testing the ability of the maldi-ms assay to predict incident acute kidney injury after fractured neck of femur surgery. the study aims to validate the findings of a urinary peptide panel previously developed and validated on a cohort of septic patients. kidney injury following surgery or as a part of severe illness is an important complication, because it can delay and reduce the chances of recovery. a reliable early test for kidney injury would be useful so that treatments to prevent or minimise it can be started as early as possible. this study, based with a group of medical researchers working with chemists, will analyse clinical urine specimens from patients undergoing major orthopaedic (bone) surgery. we will explore whether patterns of proteins in the urine could be used as an early warning that kidney injury is present before existing tests demonstrate it.

Eligibility criteria:
inclusion criteria: * fractured neck of femur * age \>50 * informed consent exclusion criteria: * refusal of consent

Keywords: urine mass spectometry observational
study of patient navigation to reduce social inequalities

Conditions: Colorectal Cancer Screening

Summary: variations in participation to the colorectal cancer screening seems to reveal social and geographical inequalities. our study will investigate whether patient navigation could increase the participation to the colorectal cancer screening and in the same time, reduce the social inequalities.


Eligibility criteria:
inclusion criteria: * insured people invited to the national french colorectal screening program are from 50 to 74 years old. * we select people who never do the screening test or are not compliant with it * among these people we select those living in the randomized geographical areas. exclusion criteria: * people who have already done the screening test at the two previous campaigns. * people who have done a colonoscopy in the previous five years or people with a family history with colorectal cancer and people who are following outside of the screening program. * people with other severe disease or in incapacity to realize the screening test * people who have another exclusion criteria to realize the screening test.

Keywords: colorectal cancer screening social inequalities patient navigator
cost-utility analysis of the outpatient versus conventional hospitalization in treatment of occlusive arterial disease

Conditions: Peripheral Arterial Disease

Summary: the purpose of this study is to assess the efficiency of outpatient surgery compared to conventional hospitalization in endovascular treatment of occlusive arterial disease. a cost-utility analysis will be conducted from a societal perspective. patients referred for peripheral arterial disease (pad) will be randomized in two arms and a 3 months follow-up will be performed.

rationale for ambulatory hospitalization is based on increased demand of hospital care, hospital budgets constraints and patients who ask for a prompt recovery. consequently, physicians should find ways to optimize the resources' allocation, without compromising quality, safety and efficiency of patient care. several studies and routine practice have shown that ambulatory hospitalization was safe but we are still lacking evidence to demonstrate the cost-utility of this kind of management.

Eligibility criteria:
inclusion criteria: * patients limping * patients with pad requiring endovascular management * patients with stabilized level 1 to 3 asa (classification of the american society of anesthesiology) * ability to walking * endovascular indicated and compatible with an introducer 5f to 7f * agreeing to participate in the study and having signed an informed consent. * agreeing to lend itself to a post-operative monitoring a duration of 30 days * social insured exclusion criteria: * no possibility of an outpatient management * previous participation in the ambuvasc study * refusal of patient to participate in the study * patient with hemostasis disorders * acute ischemia * using a more 7f introducer * radial or brachial puncture * antegrade femoral puncture * contraindication to endovascular treatment * less than one month life expectancy * participation in another clinical trial

Keywords: outpatient hospitalization randomized trial peripheral arterial disease endovascular treatment health economics
intra-pelvic organ motion for cervix cancer patient using imaging

Conditions: Cervix Cancer

Summary: patients with cervix cancer having radiotherapy experience side-effects because the radiotherapy fields have to be quite large to account for tumour movement in the pelvis during treatment, this irradiates a lot of normal tissues. this study aims to characterize and model the tumour motion, as well as the motion of surrounding normal tissues, during treatment. by doing this, the investigators can look at ways to minimise tumour motion and spare more normal tissues. by tailoring the radiotherapy dose more accurately, the investigators will reduce the side-effects of treatment and improve local control of the tumour. by doing multiple magnetic resonance imaging (mri) scans of the patients during treatment, the investigators can identify where the tumour and surrounding normal tissues are at that point in time. collecting all the information from these scans, will allow the investigators to model the motion of the tumour and these pelvic organs, and investigate the best way to target the tumour while still sparing normal tissues.

at simulation: patients will have two mri scans in addition to the standard planning ct scan. one mri scan will be with bladder full, the other will be with bladder empty. during treatment: patients will have two or three mri scans per week at their convenience. mri scans will be scheduled close to radiotherapy treatment times to minimise inconvenience for the patient. on the same day they have an mri scan, they will also have a cbct at the time of treatment. none of the images will be used to alter or influence the treatment the patient is receiving. if the patient feels that the imaging schedule is too inconvenient, they will be given the option to reduce the frequency of the scanning or to withdraw from the study.all the images will be loaded onto a password secure server. the mri scans will be fused to the planning ct scan using bone-to-bone matching. tumour and intra-pelvic organs will be contoured on the mri scans. the contours will be used to create surface meshes of each organ and with research software, we will be able to model the motion and deformation of these organs over the course of radiotherapy. using this data, we will be able to simulate the dose impact of the organ motion on different intensity-modulated radiotherapy plans. we will also explore the impact of bladder \& rectal filling on tumour motion.

Eligibility criteria:
inclusion criteria: * age ≥ 18years * biopsy confirmed cervix cancer * not suitable for surgery * suitable for radical radiotherapy * ecog 0-2 * informed consent exclusion criteria: * patients unwilling or unable to give informed consent * prior pelvic radiotherapy * contraindications to mri scan

Keywords: cervix cancer intra-pelvic organ motion cervical cancer and cbct
amg 853 phase 2 study in subjects with inadequately controlled asthma

Conditions: Asthma

Summary: the primary objective is to determine if amg 853 is effective compared with placebo as measured by change in asthma control questionnaire (acq) composite symptoms scores from baseline to week 12.


Eligibility criteria:
inclusion criteria: * males or females 18 to 65 years of age * percent of predicted fev1 ≥ 50% and ≤ 80% * at least 12% reversibility over pre-bronchodilator fev1 * inhaled corticosteroid (ics) ≥ 200 and ≤ 1000 µg/day fluticasone or equivalent. * ongoing asthma symptoms with acq score ≥ 1.5 points exclusion criteria: * history of chronic obstructive pulmonary disease or other chronic pulmonary condition other than asthma * any uncontrolled, clinically significant systemic disease * respiratory infection within 4 weeks of the screening visit
metabolic effects of one-weak heavy drinking

Conditions: Metabolic Disturbance; Alcohol; Harmful Use; Glucose Intolerance

Summary: examination of the effect of one week's unhealthy lifestyle on glucose metabolism and liver parameters in a group of young, healthy males participating in roskilde festival 2016.

metabolic effects of intermittent unhealthy lifestyle in otherwise young healthy adults are poorly studied. the investigators evaluated the effect of one week's unhealthy lifestyle on glucose metabolism and liver parameters in a group of young, healthy males participating in roskilde festival 2016. festival participants were studied before and after participation (one week) in roskilde festival 2016 and matched with controls who lead a normal life for an equivalent period of time. an oral glucose tolerance test (ogtt), abdominal ultrasound and strain elastography for liver stiffness were performed together with a bioimpedance scan and cognitive tests.

Eligibility criteria:
inclusion criteria: * bmi of 18,5-25 kg/m2 * normal liver function (assessed by asat, alat, ggt, alkaline phosphatase, albumin and bilirubin, coagulation factors ii, vii and x, inr and platelets) exclusion criteria: * planning alcohol withdrawal or dieting/a special low-fat diet during roskilde festival * diabetes or pre-diabetes * first degree relatives with diabetes * kidney disease (egft\<60 ml/min and/or albuminuria) * chronic diseases (in addition to those already mentioned) that could affect participation in festival activities (concerts and parties) * any condition in which the investigator believed would make it impossible to participate