Kornimate/medical-research-clean huggingface dataset:
impact of air pollution on the course of inflammatory rheumatism

Conditions: Rheumatoid Arthritis; Ankylosing Spondylitis; Psoriatic Arthritis

Summary: the objective of this study is to see if there is a link between air pollution and inflammatory rheumatism (rheumatoid arthritis and ankylosing spondylitis) to do this, the investigators are going to follow a cohort of about 200-400 patients for 6 months by means of a self-questionnaire, which the investigators ask the patient to fill in once a week on a fixed day, and opposite the corresponding week to put the letter corresponding to the question concerning the activity of your disease: 3 possible answers: a: no flare-up, b: short flare-up of 1 to 3 days, c: persistent flare-up of more than 3 days then the investigators will collect the questionnaire at the end of these 6 months and at each visit to the consultation or day hospital (on average every 4 to 6 weeks), and they will look to see if any relapses have occurred. at the same time the investigators will calculate the disease activity score (das or basdai) to have an objective score. then in parallel they will look at the level of exposure to air pollution according to the place of residence and work of each patient. the hypothesis is that air pollution has an influence on the activity of inflammatory rheumatism.


Eligibility criteria:
inclusion criteria: * patients with ra according to acr/eular 2010 criteria, or spondyloarthritis according to asas criteria. * patients older than 18 years of age * patients with ra or spondyloarthritis considered stable (no change in background or biological therapy for at least 3 months) and in low activity (sar 28 crp \< 3.2 for ra and basdai \< 4 for 3 months). * patient treated with biological therapy exclusion criteria: * patient with no fixed abode * patient planning to move within 6 months. * patient unable to read or understand the non-opposition notice.
ultra-low-dose whole-body ct using ai-based ct reconstruction in patients with multiple myeloma

Conditions: Multiple Myeloma

Summary: this prospective study aims to perform intra-individual comparison of the image quality between ultra-low-dose whole-body ct with deep learning reconstruction and conventional low-dose whole-body ct with iterative reconstruction in patients with suspected multiple myeloma.


Eligibility criteria:
inclusion criteria: * signed informed consent * patients with suspected multiple myeloma and scheduled for noncontrast-enhanced low-dose whole-body ct * patients who have no previous history of chemotherapy for multiple myeloma exclusion criteria: * patients who do not agree to the protocol * non-korean patients * pregnancy
observational study on the patients with rectal cancer

Conditions: Rectal Cancer; Adjuvant Chemoradiotherapy; Neoadjuvant Chemoradiotherapy; Adjuvant Chemotherapy; Surgery

Summary: the aim of this observational study is to retrospectively collect current survival data for 3995 primary rectal cancer patients who were extracted from 5097 rectal cancer patients admitted in cancer hospital, chinese academy of medical sciences from january 2000 to december 2010. moreover, based on a cox model, we want to develope a nomogram that predicts local recurrence, distant metastases, and survival for patients with rectal cancer treated with pre- or postoperative chemoradiotherapy (crt).


Eligibility criteria:
inclusion criteria: * aged older than 18 years * american joint committee on cancer (six edition) stage i through iv disease * received either transabdominal resection, transanal excision, preoperative radiotherapy or chemoradiotherapy * had the histologic subtypes adenocarcinoma (not otherwise specified, mucinous or mucin-producing, mixed cell or with mixed subtypes, tubular, and papillary) exclusion criteria: * had the histologic subtypes squamous cell carcinoma, carcinoid, neuroendocrine tumor, small cell carcinoma, leiomyosarcoma, sarcoma, gastrointestinal stromal sarcoma, melanoma, carcinosarcoma, rhabdoid tumors, or malignant peripheral nerve sheet tumors * only receive palliative surgery such as colostomy, sigmoidostomy * received palliative radiotherapy or chemoradiotherapy for metastatic disease * with unresectable distant metastasis in liver, lung, bone, central nervous system , or peritoneal transplantation * had no detailed medical records
neonatal transcatheter cardiac interventions at sohag university hospital

Conditions: Transcatheter Neonatal Cardiac Interventions

Summary: this study is performed to assess the safety, efficacy and outcome of transcatheter cardiac interventions in neonates with critical congenital heart disease at sohag university hospital

this study includes neonates with critical congenital heart diseases that require early interventions patients with untreated sepsis and coagulopathy are excluded. methods: a) clinical data: age, body weight and oxygen saturation b) echocardiographic data: cardiac anatomical diagnosis. c) catheterization data: vascular access, description of the defects, type of the device used, fluoroscopy time, radiation time, related complications and added interventions in the same setting. d) procedural details: * all procedures will be performed under general anesthesia. procedures will be performed are; 1. balloon atrial septostomy. 2. pda stent implantation. 3. pulmonary valvuloplasty. 4. aortic valvuloplasty. 5. balloon angioplasty of coarctation. 6. pda device closure for preterm neonates. e) post-procedure details: * all the patients will be transferred to nicu. * prophylactic antibiotic therapy will be given to all patients. * in patients with pda stent; heparin infusion will be maintained for at least for 24-48 hours then acetylsalicylic acid: dose; 5mg/kg/day will be added when oral feeding could be established until undergoing second-stage palliation or repair.

Eligibility criteria:
inclusion criteria: * neonates with critical congenital heart diseases that require early intervention exclusion criteria: * untreated sepsis and coagulopathy.

Keywords: catheter, neonates, congenital heart disease
evaluation of the prevalence of sars-cov-2 infection in the healthcare workers (hcws) in four hospital of the alpine region

Conditions: Covid19; Health Care Worker

Summary: the pacaap study aims to report the seroprevalence of sars-cov-2 igg antibodies among hcws testing during the massive campaign screening set up in france by french ministry of health and national authorities in four hospital of the alpine region.

in france during the first wave of the pandemic, 30,230 symptomatic healthcare workers had been reported positive. yet, the prevalence of the infection in french healthcare workers remains unknown as it mostly reflect symptomatic infections. also, the prevalence of infection was reported being higher in male healthcare workers, and in those having patients' facing roles. however, the impact of the level of exposure to sars-cov-2, the use of personal protective equipment and hospital organization to prevent infection and spread remains unclear. our study aims to report the seroprevalence of sars-cov-2 infection among french healthcare workers after the first wave of the pandemic. it also aims to explore the impact of the type of occupations and the level of exposure to the viruses on the seroprevalence of infection.

Eligibility criteria:
inclusion criteria: * hospital staff employee * employed in one of the participating centers * volunteers to perform sars-cov-2 serology * permanent or occasional staff (temporary workers, short contracts) * caregivers or not (medical, paramedical, administrative, technical staff) exclusion criteria: * staff who are not working at a participating center while participating in the study * person under guardianship or curatorship * opposition to data collection
nicotinamide in hemodialysis patients with hyperphosphatemia

Conditions: Chronic Kidney Disease; Hemodialysis; Hyperphosphatemia

Summary: study hypothesis: nicotinamide inhibits gastrointestinal phosphate absorption and serum phosphate levels of dialysis patients in a dose dependent manner.


Eligibility criteria:
inclusion criteria: * hemodialysis since 3 months or longer * hemodialysis frequency 3 times weekly * stable phosphate binder dose since one month at screening * serum phosphate level \< 2,42 mmol/l at screening * serum phosphate level \> 1,52 mmol/l after wash out phase * stable treatment with vitamin d analogues since one month at screening exclusion criteria: * congestive heart failure * acute bleeding complications * acute myocardial infarction * peptic ulcers * serious liver damage * poorly controlled diabetes * severe visual impairment * uncontrolled high blood pressure * thrombocyte count \< 120/nl * difficulties in swallowing or dysphagia * diminished intestinal motility, megacolon, pseudo- or mechanical obstruction * gastroparesis
relationship between level of gpcr autoantibodies and cardiac structure & funtions based on ucg and cmr

Conditions: STEMI

Summary: this study is a prospective cohort study，we want to observe the changes of different cardiovascular antibody levels in stemi patients undergoing emergency pci;and combined with different cardiovascular antibody levels and various indicators, evaluate the impact of ischemia-reperfusion injury and prognosis in stemi patients after emergency pci.

this study mainly observed the changes of different cardiovascular antibody levels in stemi patients undergoing emergency pci by measuring autoantibodies; and the changes of autoantibodies in stemi patients compared with coronary angiography-negative patients. at the same time, combined with different cardiovascular antibody levels and various indicators, the effect of ischemia-reperfusion injury and prognosis after emergency pci in stemi patients was evaluated. the correlation between autoantibody changes and imaging indicators in stemi patients was evaluated by cardiac color doppler ultrasound and cmr.

Eligibility criteria:
inclusion criteria: * stemi patients meet the diagnostic criteria of "guidelines for the diagnosis and treatment of acute st-segment elevation myocardial infarction (2015)"; ②stmei patients undergoing emergency pci should undergo emergency pci within 12 hours of onset at beijing friendship hospital affiliated to capital medical university; ③ the selected patients were able to complete the mri and ste examinations; ④ they agreed to be enrolled in the trial and signed the informed consent. exclusion criteria: * past myocardial infarction or revascularization (pci or cabg); ②congestive heart failure lvef\<40%; ③atrial fibrillation; ④renal insufficiency (gfr\<30 ml/min); disease; ⑥ rheumatic immune system disease; ⑦ malignant tumor; ⑧ claustrophobia; ⑨ contraindication to cmr;

Keywords: stemi gpcr pci
impact of hpv vaccination on hpv infection and cervical related disease burden in real-world settings (hpv-rws)

Conditions: HPV Infection; Cervical Disease

Summary: take as04 adjuvanted hpv16/18 vaccine as an example to evaluate the impact of hpv vaccination on hpv infection and related disease burden in the real world based on prospective cohort and yinzhou regional health information platform (yrhip), in order to bridge the gap in relevant evidence in china.


Eligibility criteria:
inclusion criteria: * permanent female resident in the yinzhou district (i.e. at least residing in the yinzhou district for a 3-year period and at least 6months in every 12-month period). * between 9 and 45 years old at time of the enrollment. * receiving first or second dose of the as04 adjuvanted hpv 16/18 vaccine (exposed group). or without any hpv vaccination history (non-exposed group). * subjects and their parents / legal guardians agreed to comply with the requirements mentioned in the protocol (e.g., physically and mentally healthy, be able to complete the baseline and follow-up survey and would comply with the visits, etc.). * written informed consent will be obtained from the subject. for subjects who are below the legal age of consent, written informed consent must be obtained from the parent(s)/lar(s) of the subject and informed assent must be obtained from the subject according to ec requirement as well as local law. subjects must understand the protocol and be voluntarily willing to join this study with written informed consent form. exclusion criteria: * pregnancy at the enrollment. * females with historical cervical diseases (i.e., cin1, cin2, cin3, and cervical cancer) before the recruitment. * after hysterectomy. * females with malignant tumor history or other severe diseases (e.g., liver failure, heart failure, etc.) whose life expectancy is less than 12 months. * females who (1) have historical hpv vaccination, or (2) are in non-exposed groups but have clear intention for hpv vaccination in next 3 years.
laparoendoscopic single-site radical nephrectomy for localized renal cell carcinoma

Conditions: Localized Renal Cell Carcinoma

Summary: surgical resection is the only potential curative treatment available for renal cell carcinoma. the purpose of this study is to clarify the surgical and oncologic outcomes of laparoendoscopic single-site radical nephrectomy for localized renal cell carcinoma.


Eligibility criteria:
inclusion criteria: * patients with localized renal cell carcinoma exclusion criteria: * patients with lymph node or distant metastasis

Keywords: localized renal cell carcinoma
minimal access surgical technique (mast) in obese patients in degenerative lumbar disease

Conditions: Degenerative Lumbar Disease

Summary: the study concerns a retrospective analysis of all subjects operated as of 1st jan 2008 using minimal access surgical technique (mast). the study is descriptive in nature and will present the observation of all cumulated patients operated with mast. the study data will include the general health information of the subjects prior to surgery, information on the surgery such as op time, blood loss, and the postoperative wound healing process (until discharge), which is on average the 10th postoperative day.


Eligibility criteria:
inclusion and exclusion criteria: * all patients who underwent minimal access spinal surgery for degenerative lumbar disease fusion surgery * patient older than 18 years * all products have been used within intended use

Keywords: complication rate in 3 cohorts (bmi < 25, > 25 and > 30)
evaluate the efficacy of using modified qing-ying decoction in atopic dermatitis children

Conditions: Atopic Dermatitis

Summary: the study aims to evaluate the clinical efficacy and safety of the modified qing-ying decoction (mqyd) for the treatment of subacute and chronic atopic dermatitis (ad) in children when compared to the placebo control through examining the clinical symptoms, quality of life, gut microbiome, and chinese medicine body constitution. this is a parallel, randomized, placebo-controlled, double-blind clinical trial. eligible subjects will be randomly allocated to receive oral mqyd granules or it's placebo granules. subjects will have 12-week of treatment, and then a 4-week follow-up.

the subjects will come for a screening visit at week 0 (baseline), then at week 6, week 12, and week 16 for chinese medicine practitioner (cmp) investigators assessments. eczema area and severity index (easi), children's dermatology life quality index (cdlqi), patient-oriented eczema measure (poem), and chinese medicine body constitution types will be assessed and filled up at different timepoints. they will receive oral herbal mqyd or placebo granules for 12 weeks and then be followed up 4 weeks after the treatment. registered cmps will provide consultation under chinese medicine theory. study medication compliance and adverse events will also be assessed at each visit. besides, they need to record the food taken in a diary before the day for taking faecal specimen for gut microbiome analysis.

Eligibility criteria:
inclusion criteria: 1. age of 4 to 17 (chinese only); 2. with easi ≥ 10; 3. subacute and chronic atopic dermatitis presenting with dry, scaly, erythematous papules and plaques; and 4. provide written informed consent form (signed by one of their parents) exclusion criteria: 1. history of allergy to chinese medicines; 2. ad with yang deficiency in syndrome differentiation, such as pale looking, always feeling cold, fatigue, chronic diarrhea with loose stool, urinary disorders such as urinary difficulty, excessive urination or incontinence 3. known overt bacterial infections in the skin; 4. known pregnancy; 5. known severe medical conditions, such as cardiovascular, liver or renal dysfunction or diabetes mellitus; 6. having used oral corticosteroids, oral antibiotics, other immunosuppressive or any preparation of oral herbal medicines for the treatment of ad in the past month; 7. having been diagnosed with scabies, allergic contact dermatitis, seborrheic dermatitis or psoriasis; and 8. has taken anti-coagulant or anti-platelet drugs in the past month. 9. has taken any probiotics, prebiotics in the last month 10. known history of glucose-6-phosphate dehydrogenase (g6pd) deficiency
hiv medication adherence in underserved populations

Conditions: Human Immunodeficiency Virus; Acquired Immunodeficiency Syndrome

Summary: the purpose of this study is to determine whether cognitive rehabilitation or psychoeducation impacts medication adherence in hiv-1 seropositive individuals.

although antiretroviral therapy (art) has proven extremely effective in the treatment of hiv and aids, the ability to effectively combat the disease is inconsequential when individuals do not take their medication as prescribed and do not attend their scheduled medical appointments. non-adherence to effective art and medical visits is widespread in the united states, especially among ethnic minorities. a recent study indicated that patients who miss a medical appointment in the first year of an hiv diagnosis show over twice the mortality rate of patients who attended all visits. this study is developed to investigate the relationship between hiv associated neurocognitive disorder (hand) and adherence to hiv treatment among traditionally marginalized populations. participants will be administered a brief neuropsychiatric screener. participants will be randomly enrolled one of two cognitive rehabilitation programs so they may learn compensatory cognitive strategies to remain treatment adherent, or they will be receive psychoeducation concerning the importance of taking their medications and regularly attending medical appointments. participants will be tracked and followed-up with regarding their treatment adherence in regular intervals over the course of 6 months.

Eligibility criteria:
inclusion criteria: * adult, age 18 and older. * able and willing to provide written informed consent. * diagnosed as hiv-seropositive by licensed enzyme-linked immunoabsorbent assay (elisa) or hiv-seropositive by western blot (wb). * diagnosed as hiv seropositive within the last two years. * willing and able to provide adequate information for locator purposes. exclusion criteria: * under the age of 18. * have ever sustained a traumatic brain injury. * have an obvious psychological/psychiatric disorder that would invalidate the informed consent process, or otherwise contraindicate participation in the study. * have a learning disability where they cannot read or write pass the third grade level. * have an active substance dependence diagnosis.

Keywords: human immunodeficiency virus acquired immunodeficiency syndrome cognitive rehabilitation minority health vulnerable populations underserved, patients medication adherence medication compliance medication non-compliance medication persistence medication non-adherence
effects of atorvastatin on blood pressure and urinary albumin excretion

Conditions: Hypertension; Hypercholesterolemia

Summary: to evaluate the possible effects of atorvastatin on ambulatory blood pressure, urinary albumin excretion, insulin resistance and arterial stiffness in hypertensive patients, beyond those on lipid profile. glycemic parameters, "novel" cardiovascular risk factors and safety parameters will be also evaluated.


Eligibility criteria:
inclusion criteria: * ldl-c\>130 or \>160 mg/dl (depending on the total risk according to the most recent recommendations25). * no previous hypolipidemic medication * ability to provide informed consent. exclusion criteria: * pregnancy or lactation * myocardial infarction or unstable angina within the past 6 months * heart failure nyha class iii-iv * renal disease (scr\>3 mg/dl or proteinuria\>3g/d) * liver disease * history of malignancy * history of drug or alcohol abuse * treatment with corticosteroids * any other condition with poor prognosis * inability to provide informed consent.

Keywords: essential hypertension
effects of irrigation activation on clinical outcomes of root canal treatment

Conditions: Periapical Periodontitis; Root Canal Infection

Summary: this study evaluates postoperative pain and radiographic healing of asymptomatic posterior teeth with chronic apical periodontitis following root-canal treatment performed using different methods of irrigation activation.

aim: to evaluate postoperative pain and radiographic healing of asymptomatic posterior teeth with chronic apical periodontitis following root-canal treatment performed using different methods of irrigation activation. methodology: in this prospective clinical trial, root-canal treatment was performed on 162 posterior teeth with chronic apical periodontitis. after routine canal preparation, patients were assigned to either a control group treated using conventional needle irrigation (cni) without activation or to one of 3 treatment groups, each of which was treated using a different activation protocol during the final irrigation \[manual dynamic irrigation (mdi), passive ultrasonic irrigation (pui), sonic irrigation (si)\]. all treatment was completed in a single visit. patients provided self-assessments of the severity of postoperative pain at 24h, 48h and 7 days using a modified 4-step visual analogue scale (vas). patients were recalled at 12 months for clinical and radiographic examinations. periodontal healing was evaluated using a periapical index (pai), with scores of 1 or 2 considered to represent treatment success and scores of 3, 4, or 5 to represent treatment failure. data were analyzed using one-way anova and kruskal-wallis tests, with differences of p \< 0.05 considered statistically significant.

Eligibility criteria:
inclusion criteria: * a non-contributory medical history * must have an asymptomatic, necrotic premolar or molar with periapical lesions of \> 2.0 x 2.0 mm around one or both roots * must be diagnosed as chronic apical periodontitis exclusion criteria: * those with clinical symptoms (acute pain) * have periapical radiolucency of \>5 mm * no previous endodontic treatment * no severe periodontal disease in the related tooth * non-restorable tooth * use of any analgesics within the previous 3 days or antibiotics within the previous month

Keywords: chronic apical periodontitis irrigation activation methods periapical index postoperative pain treatment outcome