Kornimate/medical-research-clean huggingface dataset:
prospective validation of liver cancer risk computation (liric) models

Conditions: Predictive Cancer Model

Summary: the goal of this prospective observational cohort study is to validate previously developed hepatocellular carcinoma (hcc) risk prediction algorithms, the liver risk computation (liric) models, which are based on electronic health records. the main questions it aims to answer are: * will our retrospectively developed general population liric models, developed on routine ehr data, perform similarly when prospectively validated, and reliably and accurately predict hcc in real-time? * what is the average time from model deployment and risk prediction, to the date of hcc development and what is the stage of hcc at diagnosis? the risk model will be deployed on data from individuals eligible for the study. each individual will be assigned a risk score and tracked over time to assess the model's discriminatory performance and calibration.

the investigators will conduct a prospective observational cohort study, separately deploying three separate liric models (the general population, cirrhosis, and no_cirrhosis models) on retrospective de-identified ehr data of 44 hcos in the usa, using the trinetx federated network platform. liric will generate a risk score for each individual. all risk-stratified individuals will be prospectively, electronically followed for up to 3-years to assess the primary end-point of hcc development. at the end of this period, model discrimination will be assessed, using the following metrics: auroc, sensitivity, specificity, ppv/npv. risk scores generated by the model will be divided into quantiles. for each quantile, the investigators will evaluate the following: number of individuals in each quantile, number of hcc cases, ppv, nns, sir. model calibration will be used for assessing the accuracy of estimates, based on the estimated to observed number of events. the model will dynamically re-evaluate all individual data every 6 months, re-classifying individuals (as needed).

Eligibility criteria:
the investigators will utilize the following criteria for all 3 models: inclusion criteria: * male and females age ≥40 years from all us hcos available on the platform * at least at least 2 clinical encounters to the hco, within the last year, before the study start date exclusion criteria: * personal history of hcc or current hcc (icd-9: 155.0; icd-10: c22.0) * age below 40. the same dataset will be utilized for the non-cirrhosis validation, with exclusion of all cases with cirrhosis (icd-9: 571.2, 571.5; icd-10: k70, k70.3, k70.30, k70.31, k74, k74.0, k74.6, k74.60, k74.69). for the cirrhosis validation, the investigators will include only patients with the above cirrhosis codes.
the influence of manual therapy in the quality of life in tension-type headache

Conditions: Quality of Life

Summary: the present study aims to assess the quality of life of patients suffering from tension-type headache (tth) treated for 4 weeks with different manual therapy-based techniques. the study design involved a factorial, randomized, double-blind, controlled study

object: the present study aims to assess the quality of life of patients suffering from tension-type headache (tth) treated for 4 weeks with different manual therapy-based techniques. methods: the study design involved a factorial, randomized, double-blind, controlled study of 76 subjects. they were divided into 4 groups: suboccipital inhibitory pressure was applied to the first group; suboccipital spinal manipulation was applied to the second group; a combination of the two treatments was applied to the third group; and the fourth group was a control group. quality of life was assessed using the sf-12 questionnaire (both overall and in its different dimensions) at the beginning and at the end of treatment, and after one month as a follow-up.

Eligibility criteria:
inclusion criteria: * diagnosed by a neurologist, with headache characteristics as established by the international headache society and controlled pharmacologically. exclusion criteria: * patients with infrequent etth, or with probable frequent and infrequent forms of tth they can never have vomiting or headache episodes during the treatment etth patients may experience very occasionally photophobia or phonophobia during their episodes of headache, ctth patients may experience very occasionally photophobia, phonophobia or mild nausea during headache episodes. pain aggravated by movement of the head, metabolic or musculoskeletal problems with similar headache symptoms, previous trauma to the cervical spine, active vertigo history poorly controlled hypertension, joint stiffness, atherosclerosis, or advanced osteoarthritis, patients undergoing pharmacological adaptation, excessive emotional stress, patients with heart devices joint instability, neurological disorders, laxity of cervical soft tissues, radiographic abnormalities generalized hyperlaxity or hypermobility, pregnancy.

Keywords: efficacy tension-type headache manual therapy
determination of blood tumor cells

Conditions: Leukemia, Lymphocytic, Chronic, B-Cell; Abnormalities Cell Epithelial

Summary: magnetic nanoparticles coated with anti-epcam or anti-cd52 antibodies will be tested ex-vivo in patients blood .

magnetic nanoparticles, coated with epithelial cell adhesion molecule (epcam)-antibodies are designed to interact with epithelial tumor cells. aim of this study is to see if circulating tumor cells (epcam as marker)can be removed out of the blood with the help of these particles. patients suffering from prostate, colon, lung or pancreatic cancer will be asked to test their blood. similarly, magnetic nanoparticles will be coated with antibodies, directed against non-solid tumors in the blood such as lymphoma or leukemia (cd52 as marker).

Eligibility criteria:
inclusion criteria: epithelial cell cancer, advanced stage non-solid tumors (lymphoma, leukemia) exclusion criteria: inability to understand the language of the center (german)

Keywords: epithelial cell adhesion molecule magnetite nanoparticles tumor cells
atropine for prevention of dysrhythmias caused by percutaneous ethanol instillation for hepatoma therapy

Conditions: Arrhythmia; Respiratory Arrest

Summary: ultrasound guided percutaneous ethanol injection (pei) is an established method in the treatment of hepatocellular carcinoma (hcc) and considered a safe procedure with severe complications occurring rarely. previous studies revealed, that the occurrence of bradycardia and sinuatrial blockage is quite frequent during ethanol instillation sometimes accompanied by clinical complications such as unconsciousness, respiratory arrest or seizure like symptoms. study purpose is to evaluate whether the use of i.v. atropine before starting ethanol instillation can prevent dysrhythmias during instillation. study design: randomized, placebo controlled, double blinded study. atropine or saline solution will be administered intravenously to 40 patients immediately before starting percutaneous ethanol instillation. a 6 line ecg with limb leads will be recorded at rest and during ethanol instillation to reveal possibly occurring dysrhythmias.


Eligibility criteria:
inclusion criteria: * patients with hepatoma scheduled for treatment with percutaneous ethanol instillation exclusion criteria: * contraindication for the administration of atropine like * narrow angle glaucoma * mechanic stenoses of the gi-tract * clinically relevant prostatic hypertrophy * paralytic ileus * myasthenia gravis * severe cerebral sclerosis * acute lung edema * acute myocardial infarction * cardiac insufficiency * hyperthyroidism * patients with contraindication to undergo percutaneous ethanol instillation

Keywords: atropine percutaneous ethanol instillation hepatoma bradycardia arrhythmia
long-term effect of lanthanum carbonate on bone

Conditions: Hyperphosphatemia

Summary: patients enrolled in a previous study (spd405-309), who were exposed to lanthanum carbonate (fosrenol), were eligible to continue on any prescribed treatment for hyperphosphatemia, including lanthanum carbonate (fosrenol), for an additional 5 years. patients were being observed for any bone adverse events or other serious adverse events, as well as the collection of mortality data.


Eligibility criteria:
inclusion criteria: * any patient who had exposure to lanthanum carbonate in spd405-309
a prospective study of performing mri simulation in treatment position in spinal stereotactic body radiation therapy

Conditions: Spinal Metastases

Summary: to learn the usefulness of performing mri scans in different positions and learn the best practice for spinal stereotactic body radiation therapy (spinal sbrt) planning and dose delivery.

1. objectives 1. assess the feasibility of performing mri scans in the treatment position for accurate treatment planning and dose delivery in spinal stereotactic body radiation therapy (spinal sbrt). 2. characterize the improved accuracy of image fusion between mri and ct and its dosimetric impact when performing mri scans in treatment position in spinal sbrt. 3. assess the ability of mri simulation to accurately target extended spinal targets beyond the current targeting limitations (\>3 consecutive vertebral body levels) 4. optimize the workflow of using mri simulation in treatment planning and dose delivery.

Eligibility criteria:
3.1. inclusion criteria 1. greater than or equal to 18 years of age 2. pathologically confirmed diagnosis of cancer, including, but not limited to non-small cell lung cancer, breast, prostate, renal cell, melanoma, gastrointestinal, sarcoma, thyroid, head and neck primary, and carcinoma of unknown primary 3. signed informed consent 4. willing to undergo 2 mri simulations in one or multiple sessions, one with immobilization device, and the other without. 5. patients undergoing spinal sbrt 3.2. exclusion criteria a. patient with a relative or absolute contraindication to mri (such as pacemaker, etc.) b. patients with significant instrumentation or cement at the site of interest causing artifact c. inability to tolerate with immobilization device for greater than 30 minutes
assessing the impact of dosage frequency of propranolol on sleep patterns in patients with infantile hemangiomas

Conditions: Infantile Hemangioma

Summary: the purpose of this study is to assess the baseline sleep pattern disruption for patients starting oral propranolol at the standard bid dosing regimen compared to the control (timolol) group and to determine if there is a significant improvement in the sleep patterns in infants taking oral propranolol on the tid dosing regimen versus the control (timolol) group


Eligibility criteria:
inclusion criteria: * clinically diagnosed hemangiomas. * english or spanish speaking only exclusion criteria: * parents who do not consent to the study. * significant cardiac or pulmonary disease who are unable to tolerate oral propranolol
feasibility of resting intervals during exercise programs for individuals with knee osteoarthritis

Conditions: Knee Osteoarthristis

Summary: this pilot randomize trial tests the feasibility of administering two different exercise programs in people with knee osteoarthritis. one group receives the exercise program administered as usual, and the other group received the exercise program with resting intervals.

participants will be randomly assigned to 1 of 2 treatment groups. both groups do the same exercise program 3 times a week for 12 weeks on nonconsecutive days. the only difference is that one group will perform the exercises with small resting periods between exercises as normally done in clinical practice. the other group will have two long rests of 45 minutes during the exercise training session. before and after the exercise programs, participants will undergo a series of assessments including gait analysis, mri imaging of knees, tests of muscle strength and physical performance. questionnaires will be completed. blood and synovial fluid will be collected as part of this study.

Eligibility criteria:
inclusion criteria: * age between 45 and 79 yo. * clinical diagnosis of primary, early to moderate stage knee osteoarthritis. * bmi range of 25 to 35 kg/m2. * sedentary lifestyle * knee joint is the most painful joint in the body. * ability to speak and understand english. * willingness to comply with all study procedures and be available for the duration of the study. exclusion criteria: * non-oa disease of the knee. * advanced knee osteoarthritis * knee injection in the past 3 months. * major knee trauma/surgery in the past 5 years or previous knee surgery with hardware limiting cartilage assessment.. * participate in regular exercise or physical activity . * participation in an intervention study for knee oa. * currently using a cane, walker or crutches to walk. * history of cardiovascular disease or hypertension not controlled by medication. * two or more unexplained falls in the past year. * inflammatory, autoimmune disorders, neurological, systemic, muscular, or connective tissue conditions that affect walking or ability to exercise. * contraindication to mri. * medical condition or characteristic of the participant that could place the individual at increased risk or preclude s/he from complying with study procedures. * pregnant female. * acute or terminal illness.

Keywords: knee osteoarthritis exercise feasibility
19f mri in healthy children and children with mild cystic fibrosis lung disease

Conditions: Cystic Fibrosis in Children

Summary: this study capitalizes on the emerging technology of 19f mri, using conventional 'thermally' polarized perfluorinated gas (perfluoropropane, or pfp) mixed with oxygen and studied with magnetic resonance imaging (mri) to visualize ventilation. this technique has not been studied in children. children and adolescents (6-17 years old) with cystic fibrosis (cf) who have normal spirometry will undergo 19f mri with the inhalation of an inert contrast gas to study ventilation. comparisons will be made to a cohort of healthy children (6-17 years old) who will perform the same measures. the primary outcome measure is the feasibility of conducting these studies in the pediatric population. parallel performance of multiple breath nitrogen washout (mbw) and spirometry will be used to compare the sensitivity of these outcomes to the presence of mild lung disease in these children. finally, the investigators will compare data obtained during standard breath holds with a novel "free-breathing" technique that will eliminate the need for breath holds during mri acquisition.


Eligibility criteria:
inclusion criteria: * 6-17 years old * non-smoker and non-vaper * cystic fibrosis (cf) group: must have a diagnosis of cf * no use of supplemental oxygen * they must be able to perform spirometry and have stable lung function (within 10% personal best in the last 6 months) and no exacerbations within the past 4 weeks * baseline forced expiratory volume in 1 second (fev1) \>80% with ratio of the forced expiratory volume in the first one second to the forced vital capacity of the lung (fev1:fvc) ratio \>0.7 exclusion criteria: * healthy volunteers: with any history of chronic lung disease (i.e. asthma) * active or former smoker with less than 1 year of quitting * unable to undergo an mri of the lungs and chest because of contraindications, including: * injury to the eye involving a metallic object * injury to the body involving a metallic object * presence of an implanted drug infusion device that is not mri safe * bone growth of fusion simulator * presence of cochlear, otologic, or ear implant * shunt (spinal or intraventricular) * any implant held in place by magnet * claustrophobia * unable to tolerate the inhalation of the gas mixture * facial hair preventing a tight fit of the mask used in the study * pregnancy * changes in medication that may affect cf lung disease or lung function in the past 28 days, including experimental therapies

Keywords: 19f mri ventilation pediatrics
methylphenidate in the treatment of cocaine dependent patients with adult attention deficit hyperactivity disorder - 5

Conditions: Cocaine-Related Disorders; Substance-Related Disorders

Summary: the purpose of this study is the use of methylphenidate in the treatment of cocaine dependence and attention deficit hyperactivity disorder (adhd) comorbidity.

the objective of this study is to determine the safety and efficacy of methylphenidate in a population of patients who are cocaine dependent and suffer from attention deficit hyperactivity disorder.

Eligibility criteria:
inclusion criteria: cocaine-dependent. meets the dsm-iv criteria for adhd. actively using cocaine within the past 30 days of screening. exclusion criteria: symptoms of aids. significant medical disorder. dsm-iv criteria for any substance other than cocaine, alcohol, nicotine, marijuana, caffeine. requires detoxification from etoh or benzos. history of seizures.
conservative treatment or resuturing among women with perineal wound dehiscence after vaginal labour

Conditions: Dehiscence Wound; Secondary Perineal Tear; Episiotomy; Dehiscence

Summary: the goal of this observational study is to make us more aware of the short and long-term outcomes for women having an uncomplicated healing process after a rupture or birth cut in the perineum after giving birth in relation to a healing process with a dehisced wound treated with conservative management or secondary suturing. participants will be asked to do * a gynecological examination at one month after birth and 9-12 months after birth. * have a picture taken of the healing process * answer a questionnaire at one month, three months, and 9-12 months after birth

the best way to manage perineal wound dehiscence after childbirth is unknown. currently, there is no agreed best practice recommendation for managing perineal wound dehiscence due to a lack of evidence comparing conservative management with secondary suturing. therefore, studies are urgently needed to compare the benefits and risks of both treatments. this study has the potential to significantly impact women´s health for those suffering from perineal wound dehiscence. the investigators want to include 100 women who have had a primary repair of a second-degree tear or episiotomy with a normal/uncomplicated healing process, 100 women with a second-degree tear or episiotomy identified with a dehisced wound treated with secondary resuturing, and 100 women with a second-degree tear or episiotomy identified with a dehisced wound treated with conservative management. all women who meet the inclusion criteria are recommended the same treatment and follow-up as currently present as standard care at the four hospitals that the investigators are recruiting from. the study deviates from the standard of care by offering two extra clinical examinations, one questionnaire evaluation without clinical examination, and a follow-up with pictures of the perineal tear healing process.

Eligibility criteria:
inclusion criteria: * women with a vaginal delivery who have had a primary repair of a second-degree perineal tear or episiotomy * at least 18 years old * able to understand, read and speak danish or english * able to give informed consent exclusion criteria: * none, first, third- and fourth-degree tear * cesarean section

Keywords: dehiscence secondary perineal tear episiotomy
confinement and spondyloarthritis treatment

Conditions: Spondyloarthritis

Summary: evaluate the impact of confinement on treatment use in spondyloarthritis. study hypothesis that with the confinement, subjects will stop their treatment. the main objective is to study the impact of confinement on treatment. and secondly to look for for specific psychological profile linked to the interruption of the treatment. the study population consists of patients with spondyloarthritis and belonging to a patient association (acs). all patients over 18 are included. a mailing questionnaire will be send to all patients. data on diseases activity and treatment will be collected


Eligibility criteria:
inclusion criteria: * spondyloarthritis, * age over 18 ans * treatment by nsaid or biological treatment to be part of the patient association "acs" (action contre les spondylarthropathies).
effect of wii fit training in comparison to vestibular rehabilitation training on balance in patients with benign paroxysmal postional vertigo

Conditions: Benign Paroxysmal Positional Vertigo; Balance; Vertigo

Summary: this study is a randomized control trial and the purpose of the study is to determine the effect of wiifit training in comparison to vestibular rehab training on balance in patients with benign paroxysmal positional vertigo

effects of wiifit training will be assessed for balance and vertigo which includes the parameters of balance training. benign paroxysmal positional vertigo patients aged 30-60 years the participants will be assessed through vestibular rehabilitation questionnaire (vrbq), dizziness handicap inventory (dhi), functional reach test, clinical test for sensory integration in balance and vertigo symptom scale. informed consent will be taken after which the participants will be recruited into two groups, where one group will receive wiifit training and other group will receive vestibular rehabilitation training. base-line and post-treatment measurement will be taken for analysis.

Eligibility criteria:
inclusion criteria: * patients diagnosed with benign paroxysmal positional vertigo. * aged 30-60 years. * ability to stand and walk independently. * male and female * positive dix hallpike test * dhi scale: 36-42 (moderate handicap) exclusion criteria: * patients with history of vestibular surgery or cochlear implantation. * patients with history of seizures or epilepsy. * patients with a pacemaker or implantable cardioverter-defibrillator(icd). * patients with history of severe head injury or concussion within the past year. * no other vestibular disorders or conditions that may affect balance.
18-fluorofuranylnorprogesterone (ffnp) pet/mri as a potential biomarker of response to progesterone therapy

Conditions: Complex Atypical Hyperplasia; Endometrial Cancer

Summary: purpose: the purpose of this study is to evaluate ffnp pet/mri's utility for predicting response to levonorgestrel-releasing intrauterine device (lr-iud) hormonal therapy for complex atypical hyperplasia (cah) and endometrial cancer (ec). participants: eight women with histologically confirmed cah or grade 1 ec who have planned treatment with lr-iud will be recruited.. procedures (methods): the is a prospective, single arm, pilot study of 8 participants who will receive one ffnp pet/mri scan. medical records will be followed for 6 months.


Eligibility criteria:
inclusion criteria: * female age 18 or older * histologically confirmed cah or grade 1 ec * no prior surgical or hormonal treatment for cah or grade 1 ec * planned treatment with levonorgestrel-releasing intrauterine device (lr-iud) for cah or grade 1 ec exclusion criteria: * inability to complete pet/mr scans due to severe claustrophobia * institutionalized subject (prisoner or nursing home subject) * implanted metallic devices, parts, vascular clips, or other foreign bodies. * known hypersensitivity to gadolinium or ffnp or to any component of gadolinium or ffnp refractory to standard medications (antihistamines, steroids) * impaired kidney function (serum creatinine level \> 1.8 mg/dl or a glomerular filtration rate \< 60 as approximated using serum creatinine levels) unless anuric and on dialysis. * any woman who is pregnant or has reason to believe she is pregnant (the possibility of pregnancy has to be excluded by negative urine (β-hcg) results, obtained within 24 hours before ffnp administration, or on the basis of patient history) * prior hormone treatment for breast cancer