Kornimate/medical-research-clean huggingface dataset:
clinical research plan for human myopia models

Conditions: Human Myopia Model

Summary: collect optical biological parameters, refractive index data, and other related parameters of myopia and refractive errors in children and adolescents, and establish an optical model of myopia in children and adolescents.

experimental research purpose:collect optical biological parameters, refractive index data, and other related parameters of myopia and refractive errors in children and adolescents, and establish an optical model of myopia in children and adolescents. case selection: this study requires the inclusion of children and adolescents aged between 4 and 18 years who have been diagnosed with myopia and refractive errors through medical examination of dilated pupils. plan: collect eye parameters such as refractive power, whole eye aberration, corrected visual acuity, pupil diameter, axial length, anterior and posterior corneal surface curvature, and corneal thickness of all subjects under 9 non dilated stimuli.

Eligibility criteria:
selection criteria: 1. gender unlimited 2. age 6-16 years old 3. through medical optometry with dilated pupils, the spherical equivalent refractive index is within the range of -0.5ds\~-8.0ds, and the cylindrical lens is ≤ -0.75dc exclusion criteria: 1. patients with corneal diseases such as corneal ulcers, corneal opacities, and corneal leukoplakia 2. patients with refractive media opacity, such as cataracts and vitreous hemorrhage 3. glaucoma patients 4. patients with nystagmus 5. patients with strabismus and amblyopia 6. patients with fundus diseases 7. patients with a column mirror range greater than -0.75dc 8. patients with binocular anisometropia ≥ 1.0d 9. corneal contact lenses (such as corneal reshaping lenses, multifocal contact lenses, and rgp) with a history of wearing 10. long term history of low concentration atropine and other ocular medications 11. wearing history of functional lenses such as asymptotic multifocal, multi-point myopic defocus, peripheral defocus, etc 12. patients participating in other eye clinical trials 13. individuals with mental illness or cognitive impairment who are unable to cooperate * researchers believe that other reasons are not suitable for clinical trial participants, such as poor physical condition on the day of the trial
ultrasonic cavitation on abdominal obesity in adolescent females

Conditions: Ultrasonic

Summary: the purpose of this study was to determine the effect of ultrasonic cavitation on abdominal obesity in females. fifty volunteer females with abdominal obesity participated in the study.

the purpose of this study was to determine the effectiveness of ultrasonic cavitation on abdominal obesity in adolescent females. fifty volunteer females with abdominal obesity participated in the study. group (a) consisted of 25 females who treated by ultrasonic cavitation on abdominal region for 30 minutes and aerobic exercises for 30 minutes, 2 times per week for 6 weeks ; group (b) consisted of 25 females who performed aerobic exercise and low caloric diet.

Eligibility criteria:
inclusion criteria: * their ages were range from 17 to 21 years old. * their body mass index less than 35kg/m2. exclusion criteria: * females with bmi exceed 35kg/m2. * females have psychological disorders. * cardiac diseases. * hypertension

Keywords: ultrasonic aerobic exercise diet
determination of the nature of the endogenous ligand of trem-1 and its use as a new diagnostic biomarker in sepsis

Conditions: Sepsis

Summary: step 1: identification and characterisation of the trem1l protein from samples already available characterised at the hospital central of nancy step 2: study of the isoforms of trem1l in correlation with the prognosis of sepsis, step 3: implementation of assay methods for trem1l (elisa or supra ms) step 4: validation of assays for trem1l and its isoforms in a larger number of subjects (inclusion of samples from dijon chu and besançon chu)


Eligibility criteria:
inclusion criteria: * patients hospitalised in a medical intensive care unit whatever the reason * written informed consent obtained exclusion criteria: * patients less than 18 years old or under guardianship, persons without national health insurance.
pars plana vitrectomy (ppv) versus preoperative intravitreal bevacizumab plus ppv to treat diabetic tractional retinal detachment (ibetra)

Conditions: Diabetic Retinopathy; Retinal Detachment

Summary: the purpose of this study is to compare the amount of intraoperative intraocular bleeding during 23-gauge pars plana vitrectomy (ppv) for diabetic traction retinal detachment (trd) with and without preoperative intravitreal bevacizumab treatment.


Eligibility criteria:
inclusion criteria: * macular traction retinal detachment lasting three months or less secondary to diabetic retinopathy. exclusion criteria: * massive vitreous hemorrhage preventing from detailed posterior pole examination; * previous intra-ocular surgery other than cataract surgery * hemodialysis, known bleeding disorders or use of anticoagulants drugs other than aspirin * prothrombin time, partial thromboplastin time or platelet count without normal limits * history of previous thromboembolic events

Keywords: diabetic retinopathy retinal detachment vitreous hemorrhage bevacizumab preoperative pars plana vitrectomy
safety and efficacy evaluation of bcma-cart for treating multiple myeloma

Conditions: Multiple Myeloma

Summary: this trial aims to evaluate the safety and efficacy of bcma-cart in treating patients with relapsed or refractory multiple myeloma.

bcma(b-cell maturation antigen) is a tumor antigen of multiple myeloma . using a genetic engineering strategy to assemble an anti-bcma car(chimeric antigen receptor) in autologous t cells will help these cart cells to recognize and kill bcma-expressing mm tumor cells. this trial aims to evaluate the safety and anti-tumor efficacy of autologous bcma-cart in treating relapsed or treatment refractory multiple myeloma.

Eligibility criteria:
inclusion criteria: * have the capacity to give informed consent; * confirmed diagnosis of active mm as defined by nccn and imwg criteria; * have a diagnosis of bcma+ multiple myeloma (mm), (≥ 5% bcma+ in cd138+ plasma cells by flow cytometry obtained within 45 days of study enrollment); * refractory and relapsed mm patients after \> 2 cycles of induction therapy,or,have relapsed or treatment refractory disease following autologous stem cell transplant (asct); * ecog score=0-2. exclusion criteria: * pregnant or nursing women; women of reproductive potential must have a negative serum pregnancy test performed within 48 hours of starting conditioning chemotherapy; * active infection, hiv infection, syphilis serology reaction positive; * active hepatitis b, hepatitis c at the time of screening; * significant hepatic dysfunction as following, sgot(serum glutamic-oxaloacetic transaminase)\> 5 x upper limit of normal; bilirubin \> 3.0 mg/dl; * lymphotoxic chemotherapeutic agents within 2 weeks of leukapheresis serious mental disorder; * with severe cardiac, liver, renal insufficiency, diabetes and other diseases; * participate in other clinical research in the past three months; previously treatment with any gene therapy products; * contraindication to cyclophosphamide or fludarabine chemotherapy.
zosuquidar in combination with daunorubicin and cytarabine in patients ages 55-75 with newly diagnosed acute myeloid leukemia (aml)

Conditions: Leukemia, Myeloid

Summary: chemotherapy drugs use different ways to stop cancer cells from dividing so they stop growing or die. zosuquidar may help daunorubicin and cytarabine kill more cancer cells by making cancer cells more sensitive to the drugs. it is not yet known whether daunorubicin and cytarabine are more effective with or without zosuquidar in treating acute myeloid leukemia.

purpose: phase i: to evaluate the safety of different doses of zosuquidar. phase ii: this study is designed to study the safety and effectiveness of zosuquidar when given with daunorubicin and cytarabine in newly diagnosed aml patients.

Eligibility criteria:
inclusion criteria: * newly diagnosed acute myeloid leukemia * ages 55-75 years exclusion criteria: * acute promyelocytic leukemia (fab m3) * patients must not have received prior chemotherapy for aml. * prior exposure to anthracycline * use of any investigational agent within 4 weeks prior to enrollment into the study for phase ii: * patients must be p-glycoprotein positive

Keywords: leukemia, myeloid relapse chemotherapy zosuquidar daunorubicin cytarabine acute aml adult aml
swallowing evaluation by hrim in patients with cervical spondylosis

Conditions: Upper Esophageal Sphincter Relaxing Pressure

Summary: patients with cervical spondylolysis may have swallowing or eating difficulty. in this study, we will use high resolution impedance manometry to evaluate these patients' detailed swallowing mechanisms.

this study will aim to evaluate swallowing function in patients with cervical spondylolysis by using high resolution impedance manometry (hrim) along with oral frailty and dysphagia questionnaires. researchers will plan to enroll 50 patients to investigate this issue. the inclusion criteria will be as following:1) age higher or equal to 20 years old; 2) patients with cervical spondylolysis or associated symptoms. the exclusion criteria will be as following: major organ dysfunction, including chronic kidney disease, bleeding tendency. the primary outcome will be the upper esophageal sphincter relaxing pressure. the researchers will hope to find the swallowing dysfunction mechanisms in these patients.

Eligibility criteria:
inclusion criteria: * patients with cervical spondylosis associated symptoms or expected to undergo cervical spine surgery * patients with associated swallowing difficulty symptoms exclusion criteria: * major organ dysfunction, such as renal insufficiency or bleeding tendency
safety and efficacy of milep versus standard eep

Conditions: Benign Prostate Hypertrophy(BPH); LUTS(Lower Urinary Tract Symptoms)

Summary: endoscopic enucleation of the prostate (eep) is a standard treatment for benign prostatic hyperplasia (bph), with modifications such as milep that utilizes smaller instruments. the reduced resectoscope diameter in milep may help decrease rates of stress urinary incontinence (sui) and urethral strictures. objective: to compare the efficacy and safety of milep and standard eep with a thulium fiber laser (tfl).


Eligibility criteria:
inclusion criteria: luts presence, proven by: 1. ipss questionnaire (score \>20); 2. or uroflowmetry result (qmax \<10 ml/s); exclusion criteria: * prostate volume \> 120 cc * prostate cancer on pathology; * urethral strictures; * bladder calculi; * prior prostate surgery; * neurogenic bladder dysfunction.
prophylaxis of wound infections- antibiotics in renal donation

Conditions: Infection

Summary: the aim of this study is to see whether antibiotics given at the start of laparoscopic kidney donation surgery prevent infection.

subjects undergoing laparoscopic donor nephrectomy will be randomised to either a single dose of intravenous co-amoxiclav or placebo prior to surgery. outcome measures include any infections, length of stay and costs

Eligibility criteria:
inclusion criteria: * all adult patients (over 18 years) undergoing hand-assisted laparoscopic donor nephrectomy, who have given written informed consent, will be included. * patients whose first language is not english will be included; they comprise a significant part of our patient population and we will use translation services as is our normal practice. * women of child-bearing age taking adequate contraception will be included. exclusion criteria: * patients with a known allergy to penicillin or other antibiotics. * patients with mrsa colonisation. * participation in another investigational study within the previous 90 days. * pregnant or breast-feeding women.

Keywords: living donation antibiotics laparoscopic surgery
pancreatic cancer and carbon ion radiotherapy

Conditions: Pancreatic Cancer

Summary: irradiation of non-operable pancreatic cancer with carbon ions (c12). this therapy is expected to be more effective than the current gold standard of photon irradiation applied in the case of non-operable pancreatic cancer.


Eligibility criteria:
inclusion criteria: * histologically confirmed, inoperable primary or local recurrent pancreatic cancer * written informed consent (must be available before enrollment in the trial) * karnofsky performance score \> 60 or ecog-status 0/1 (at least: patient should be able to take care of himself, although daily-life activity or work is not possible) * age ≥ 18 years exclusion criteria: * no clear difference between tumor edge and upper gastrointestinal tract in baseline imaging * extensive lymphatic metastases * disability of subject to understand character and individual consequences of the clinical trial * distant metastases * previous radiotherapy of the upper abdomen * active medical implants (e.g. pacemaker, defibrillator), contradicting radiotherapy at hit * participation in another clinical study or observation period of competing trials, respectively
chung-ju metabolic disease cohort (cmc) study

Conditions: Metabolic Diseases

Summary: this is an observational study on the prevalence and incidence of diabetes and osteoporosis in a rural area of korea.

diabetes, metabolic syndrome and dyslipidemia are common and rapidly increasing in asia. our group constructed a cohort in chung-ju city, a rural area in korea, to observe the prevalence of metabolic diseases and its risk factors since 2003. about 12,000 subjects participated in this cohort study till 2006. now, we are planning to follow-up these subjects and provide health examinations from may, 2007 to feb, 2011. the prevalence and incidence of metabolic diseases including diabetes, hypertension, metabolic syndrome, dislipidemia and osteoporosis will be observed.

Eligibility criteria:
inclusion criteria: * adults over 30 years of age living in chung-ju city (who participated in 2003-2006 cohort study) exclusion criteria: * age under 30 * subjects with known diabetes

Keywords: diabetes metabolic syndrome dyslipidemia osteoporosis
increasing vegetable intake in children

Conditions: Obesity; Behavior; Food Habits

Summary: the purpose of this study is to test the feasibility of an innovative approach to increase the amount of vegetable's (v) intake consumed by preschool children who are predominately african-american (aa) and hispanic-american (ha).

the purpose of this study is to test the feasibility of an innovative approach to increase the amount of vegetable's (v) intake consumed by preschool children who are predominately african-american (aa) and hispanic-american (ha).the primary endpoint will be changes in v consumption in high school children with the hypothesis that a puppet intervention will increase their v consumption by preschool children. to achieve the project goal, our specific aims (sa) are to: sa1: successfully recruit 6 preschool (ps) centers and 168 aa and 168 ha children 3 to 5 y enrolled there. sa2: conduct individual interviews for formative assessment of the puppet shows. sa3: develop the manual of operation and intervention protocols sa4: develop 4 videotaped theatre-based puppet shows that are developmentally and cognitively appropriate for use with 3- to 5-year-old aa and ha children sa5: pilot-test the feasibility of the puppet intervention with 3 intervention and 3 control hs centers. sa6: use the data collected in aim 5 to estimate parameters required to conduct a group randomized trial for an evaluation of the efficacy of the intervention. the primary hypothesis (h1) to be tested is that children who receive the puppet intervention will demonstrate increased v consumption in hs compared to children in the control group.

Eligibility criteria:
inclusion criteria: * healthy * non-patient * normals * african-american * hispanic-american * 3 to 5 y olds exclusion criteria: * pregnant woman * neonates * dietary restrictions * chronic disease * developmental disabilities * special education * does not read or write in spanish or english

Keywords: vegetables head start preschool children theater puppet
influence of chemotherapy on postural control in women with cancer

Conditions: Cancer, Breast; Cancer, Gynecologic

Summary: the aim of this study is to understand the strategies for adapting postural control in patients who have received chemotherapy treatment for gynaecological cancer.

chemotherapy can cause many side effects, including peripheral neuropathies. chemotherapy induced peripheral neuropathies (cipn) are primarily sensory impairments that can alter the signals for somatosensory feedback and thus affect the postural control in the standing position. the objective of this study is to evaluate the impact of chemotherapy and peripheral neuropathies on postural control in the standing position. as balance maintenance is a complex construct involving different systems, this study will evaluate maintenance strategies during sensory disturbances in order to better understand post-chemotherapy coping strategies. these sensory disturbances concern vision (eyes closed) and the alteration of the somatosensory system (foam under the feet and vibration system). in addition, this study will evaluate balance in double task situations and dynamic stability. given the consequent impact of chemotherapy and peripheral neuropathies on quality of life, a quality of life questionnaire will also be administered.

Eligibility criteria:
inclusion criteria: women * between 18 and 65 years; * with a gynaecological cancer about to start chemotherapy known to be neurotoxic (paclitaxel, docetaxel, nab-paclitaxel, or paclitaxel-carboplatin); * able to stand upright for 30 s on a flat surface without assistance; * able to provide written consent exclusion criteria: women * with pre-existing vestibular, uncorrectable visual, or somatosensory disorders or other pathologies altering postural control that would influence testing; * with exposure to known neurotoxic chemotherapy (paclitaxel, docetaxel, nab-paclitaxel, vinorelbine, trastuzumab-emtansine, eribulin, or paclitaxel-carboplatin) that may have caused previous cipn; * with an inability to perform the test due to poor comprehension of instructions or psychological problems.

Keywords: postural control balance chemotherapy induced peripheral neuropathy quality of life
the effect of resistant starch bagels on risk factors of type 2 diabetes and colorectal cancer

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of this study is to determine if consumption of bagels made with resistant starch for 8 weeks can improve markers of type 2 diabetes, colon cancer and satiety in adults.

using a randomized, double-blind crossover study design, we will determine the effect of consuming bagels made with resistant starch daily for 8-weeks can reduce the risk of type 2 diabetes and colon cancer in an adults who are at an increased risk for type 2 diabetes. additionally, we will compare the satiating effect of these bagels to that of a standard bagel.

Eligibility criteria:
inclusion criteria: * males and postmenopausal females at least 40 year old * bmi ≥25 and \<40 kg/m2 * waist circumference ≥ 102 cm for men, ≥88cm for women * canrisk score ≥21 which indicates an elevated risk for type 2 diabetes exclusion criteria: * diabetes mellitus (fasting blood glucose ≥ 7.0 mmol/l) * restrained eating habits * gastrointestinal conditions (celiac's disease, crohn's disease, ulcerative colitis, inflammatory bowel disease) * renal conditions * hepatic conditions * surgery or major medical event within 3 months of study start date * select medication use (glycemia medications, cholesterol-lowering agents, antibiotics within 6 months of the study, other medications known to influence blood glucose insulin, cholesterol, triglycerides, incretin hormones of the digestive tract microbiome) * select natural health product (nhp) use (phytosterols or phytosterol functional foods, other nhps intended for glycemic or cholesterol control) * gluten allergy or intolerance * alcohol consumption \>15 drinks/week for men and \>10 drinks/week for women * significant international travel within 6 months of the starting the study, or plans to travel internationally during the study.

Keywords: type 2 diabetes resistant starch postprandial glucose postprandial insulin satiety
effect of virtual reality in patients with long covid-19

Conditions: COVID-19

Summary: sars-cov-2 was first detected in wuhan, hubei province, china, in late 2019. it is a highly contagious virus that has been reported to occur in humans and is said to cause pneumonia. covid-19 infection is transmitted through droplets during coughing and sneezing and through contact with the mouth, nose or eyes after contaminated hands. the most obvious symptoms of covid-19 symptoms include cough, dyspnea and fever. covid-19, which can also be seen asymptomatic, is in intensive care it may be severe enough to require hospitalization, cause multiple organ failure and even death it could be. musculoskeletal symptoms such as fatigue, myalgia, and arthralgia are common with covid-19 are the symptoms. the first case in turkey was reported on march 11, 2020. long-term covid or chronic post covid syndrome are multi-system syndromes that last more than 12 weeks and physical, cognitive, psychological, social and occupational domains. the most commonly reported long covid symptoms are; fatigue, shortness of breath, cough, joint pain, chest pain. virtual reality application provides its users with content created using computer technology. in a virtual environment with a high perception of reality, the aim is to enable mirror neuron activation, enabling the individual to interact with virtual objects and events with three-dimensional movements and to create the perception of doing all these in the real world. virtual reality for training, treatment, rehabilitation, analysis and testing purposes in healthcare can be used. it is possible to use virtual reality for different purposes, for treatment and rehabilitation. with virtual reality applications in treatment and rehabilitation processes it was stated that patient motivation will increase and patient fear and anxiety will decrease. no study was found in the literature investigating the effect of virtual reality application on fatigue, functional capacity and respiratory function in long-term covid-19 patients. the purpose of this study; to investigate the effect of virtual reality application on fatigue, functional level and respiratory function in long-term covid-19 patients.


Eligibility criteria:
inclusion criteria: * being between the ages of 18 - 65 * having been diagnosed with covid-19 * at least 12 weeks have passed since the diagnosis of covid-19 and the symptoms continue * to be cooperative exclusion criteria: * having been koah * people with severe visual and cognitive impairment * having a neuromuscular disease * having a cardiac or pulmonary surgery