Kornimate/medical-research-clean huggingface dataset:
personalized management of autoimmune diseases with ai-guided (genais tm) dietary supplementation

Conditions: Autoimmune Diseases

Summary: the study "personalized management of autoimmune diseases with ai-guided (genais tm) dietary supplementation" investigated the effectiveness of ai-guided dietary supplement (ds) prescriptions compared to standard physician-guided prescriptions in managing autoimmune diseases. this 6-month randomized controlled trial included 160 participants with conditions like rheumatoid arthritis, lupus, and multiple sclerosis. participants were divided into two groups: one received ds based on physician judgment, and the other based on genais ai system analysis. primary outcomes focused on changes in disease activity, while secondary outcomes included quality of life, metabolic markers, and ds adherence. data collection involved genetic, metabolic, and clinical profiling, with ethical considerations ensuring participant confidentiality and informed consent


Eligibility criteria:
inclusion criteria: * diagnosed with an autoimmune disease (e.g., rheumatoid arthritis, lupus, multiple sclerosis) according to established clinical criteria. * moderate to severe disease activity as indicated by standardized measures (e.g., das28 for rheumatoid arthritis, sledai for lupus). * stable on existing autoimmune medication regimen for at least 3 months prior to the study. * willingness to provide genetic and metabolic data. * written informed consent. exclusion criteria: * current or past history of severe psychiatric conditions or other severe chronic diseases. * significant medical conditions like severe renal, hepatic, or cardiovascular diseases that may interfere with the study outcomes. * use of dietary supplements that affect immune function within the last 3 months. * pregnancy or breastfeeding. * recent changes in autoimmune medication within the last 3 months. * participation in another clinical trial within the last 30 days.

Keywords: ai-guided dietary supplementation genetic profiling metabolic profiling disease reduction
allergic bronchopulmonary aspergillosis prescreening study

Conditions: Allergic Bronchopulmonary Aspergillosis; Asthma; ABPA

Summary: this prescreening study is being conducted to diagnose abpa in selected patients with asthma and to increase the potential number of eligible participants for the ongoing study 601-0018 of pur1900 in subjects with abpa. see: nct05667662. additionally, this prescreening study may provide information that could assist the conduct of future studies conducted by pulmatrix.

see nct05667662 for a detailed description fo the main abpa study. this prescreening study is designed to diagnose abpa in patients with asthma to potentially increase the number of eligible participants for the ongoing nct05667662 study. this diagnosis will be confirmed through chest x-rays and a blood sample.

Eligibility criteria:
inclusion criteria: 1. provide written informed consent before the performance of any study-specific procedures at the in-clinic visit. 2. is a male or female ≥18 years old. 3. has a bmi of ≥18.0 and \<40.0 kg/m2 at the in-clinic visit. 4. meets the following criteria: 1. has a diagnosis of asthma. 2. at least 1 exacerbation requiring a systemic glucocorticosteroid(s) or hospital admission in the last 10 months. 3. for patients on a biologic agent, at least one exacerbation requiring a systemic glucocorticosteroid(s) or hospital admission must have occurred at least 3 months after the initiation of the biologic agent. 5. is willing and able to comply with all study procedures exclusion criteria: 1. has used omalizumab (xolair®) in the 11 months prior to screening or plans to use omalizumab during the study. 2. has a current diagnosis of any chronic airway disease other than asthma, abpa, or bronchiectasis believed to be related to abpa, such as chronic obstructive pulmonary disease, pulmonary fibrosis, cf, or churg-strauss syndrome. 3. currently requiring medications that are sensitive substrates for cyp3a4-mediated metabolism or medications that are contraindicated during and 2 weeks after treatment with oral formulations of itraconazole without the possibility of washout (see appendix 4). 4. smoking marijuana or tobacco, the use of e-cigarettes, vaping, or any other smoking is prohibited during the study. -

Keywords: abpa allergic bronchopulmonary aspergillosis asthma
pet imaging of brain amyloid in normal pressure hydrocephalus

Conditions: Normal Pressure Hydrocephalus

Summary: this study will determine the level of association between the quantitative estimates of brain uptake of \[18f\]flutemetamol and the quantitative immunohistochemical estimates of amyloid levels in biopsy samples previously obtained during shunt placement in patients who have normal pressure hydrocephalus (nph).


Eligibility criteria:
inclusion criteria: * the subject is 50 years old or older. * the subject has had a frontal lobe cortical biopsy adequate for the detection and quantitation of amyloid. * informed consent has been signed and dated by the subject/and/or subjects' legally acceptable representative, if applicable, in accordance with local regulations. exclusion criteria: * the subject has a contraindication for mri or pet. * the subject has a known or suspected hypersensitivity/allergy to \[18f\]flutemetamol. * the subject has participated in any clinical study using an investigational agent within 30 days of dosing.

Keywords: amyloid nph normal pressure hydrocephalus pet positron emission tomography suvr standard uptake value ratios
the effect of age, physical fitness and a single bout of aerobic exercise on motor and cognitive functions

Conditions: Physical Activity; Age-related Cognitive Decline

Summary: the proposed study is intended to examine the connection between two types of inhibition - cognitive and motor and the connection between motor inhibitory functions and a single bout of physical exercise in the context of age and physical fitness.


Eligibility criteria:
inclusion criteria: * non-smokers * do not take psychiatric drugs on a regular basis * geriatric depression scale score less than 3 * mini-mental state examination score higher than 27 * healthy and able to exercise at medium intensity exclusion criteria: * all others
study evaluating vaccine in adults with hiv

Conditions: HIV Infections

Summary: the main purpose of this study is to learn whether the study vaccine and the adjuvants(drugs that are used to help immune response) have an acceptable safety profile in treating individuals with hiv. a second purpose for this study is to understand how your immune system responds to the study vaccine with the adjuvants. understanding these differences could be useful in several ways. first, it might help identify people whose disease is likely to respond to the study vaccine with the study adjuvants. second, the information might be useful in developing other treatments for people whose disease does not respond to the study vaccine with the adjuvants.


Eligibility criteria:
inclusion criteria: * must be hiv positive. * receiving stable haart for a minimum of 6 consecutive months immediately before screening. * cd4 t-cell count greater than 350 mm cubed/ml at time of screening and no reported cd4 t-cell count less than 250 mm cubed/ml at any time before screening. other inclusions apply exclusion criteria: * any chronic symptomatic infection other than hiv. * history of diagnosed autoimmune disease (currently active or under control). * use of any prior hiv vaccine (prophylactic and/or therapeutic) within one year before or during screening (documented, unblinded placebo recipients from previous clinical trials may participate without this time restriction). other exclusions apply

Keywords: hiv vaccine treatment experienced
shoulder position in volleyball players with shoulder pain

Conditions: Shoulder Pain

Summary: the aim of this study is to assess the relationship between shoulder position and the presence of pain in volleyball players. to do this, will be measured pain sensation and the position of acromion process

the position is defined as the alignment of body segments at a given time. the assessment of the position is part of the physical examination. recent studies have shown that photometry can be a reliable method to assess posture. the measurement of angles can identify situations as the forward position of the head and shoulder protraction. the aim of this study is to assess the position of the shoulder, using photometry by the measurement of angle between acromion process and seventh cervical vertebra, and the relationship with the presence of pain in volleyball players. for this study will be recruited thirty nine volleyball players. the variables measured are pain sensation registered with a visual analog scale and the position of acromion process measurement with photometry

Eligibility criteria:
inclusion criteria: * over 16 years old * minimum of 3 days per week of training * with or without shoulder pain exclusion criteria: * less than 1 year practicing volleyball
effect of exercise training in autonomic modulation in breast cancer patients

Conditions: Breast Neoplasms; Autonomic Nervous System Diseases

Summary: the aim of this study is to evaluate the effect of exercise training in the autonomic nervous system activity in breast cancer patients, who underwent doxorubicin medication.


Eligibility criteria:
inclusion criteria: * breast cancer patients at stages 1, 2 and 3; * sedentary; * currently at treatment; * 4-6 months after surgery exclusion criteria: * musculoskeletal injuries or disorders; * mental illnesses * stage 4 (metastasis) * enrolled in other exercise program
the efficacy of ginger powder as an analgesic for intraoperative and post- endodontic pain management

Conditions: Endodontic Disease

Summary: the aim of the study is to evaluate the analgesic effect of ginger powder capsules compared to placebo on intra-operative and post-operative pain of single-visit endodontic treatment of mandibular molars with symptomatic irreversible pulpitis.

the pharmacological pain management usually includes administration of systemic analgesics, anti-inflammatory drugs, or antibiotics drugs. the inhibition of the inflammatory process is one of the methods to reduce or prevent pain during and after treatment. ginger has a lengthy history of use as a herbal medicine. ginger has been used in traditional chinese and indian medicine to treat a variety of diseases, including arthritis, stomachaches, diarrhea, nausea, asthma, and respiratory problems. it was discovered that ginger also contains substances that prevent pg production. this discovery gave its anti-inflammatory benefits a solid scientific justification. following research, it was discovered that some of the components of ginger share pharmacological traits with a novel family of dual-acting nsaids. these substances have significantly fewer adverse effects than traditional nsaids and can inhibit arachidonic acid metabolism via both the cyclooxygenase (cox) and lipoxygenase (lox) pathways. various animal studies have shown that taking dried ginger or ginger extract orally can decrease acute inflammation. numerous clinical studies back up the effectiveness of ginger in treating osteoarthritis, and in some instances, a noticeable decrease in knee pain has been reported. in some of these studies, it was discovered that ginger, even when used for extended amounts of time, significantly reduced pain and swelling in patients with osteoarthritis, rheumatoid arthritis, and muscular pain. there have been no studies done to evaluate the impact of ginger powder on intra and post-endodontic pain. in order to find the effects of ginger powder capsules on pain after endodontic treatment, the current study was performed.

Eligibility criteria:
inclusion criteria: 1. patients aging between 18-45 years old. 2. patients with mandibular molar with signs and symptoms of symptomatic irreversible pulpitis. 3. systemically- healthy patients (asa i or ii). 4. patients who agree to attend for recall appointments. 5. patients who can understand pain scale and can sign the informed consent. exclusion criteria: 1. pregnant or lactating female patients. 2. patients allergic to ginger, articaine or any other medicament material used in the study. 3. history of peptic ulceration. 4. periapical abscess or fistula. 5. non-restorable teeth. 6. moderate or severe marginal periodontitis i.e. pocket probe\>3mm. 7. patients on aspirin, clopidogrel, dalteparin and warfarin. 8. radiographic evidence of external or internal root resorption vertical root fracture, perforation, calcification.
study of collateral circulation in patients with symptomatic intracranial anterior circulation occlusion

Conditions: Collateral Circulation; Large-artery Occlusion; Cerebral Infarction

Summary: intracranial artery stenosis is the leading cause of stroke onset or recurrence in asian. multiple studies have shown that anterior circulation is most common in intracranial artery stenosis, especially the middle cerebral artery in patients with symptomatic or asymptomatic ischemic stroke. based on the clinical experiences, we found that the cerebral collateral development can affect clinical symptoms seriously in patients with large artery stenosis. compensated blood flow can reach the ischemic area through collateral circulation (including circle of willis, leptomeningeal collaterals, extracranial to intracranial collaterals, and new angiogenesis) when the blood-supplying artery of the brain is severely stenotic or even occluded, however, considerable differences across individuals exist. studies have shown statins and butylphthalide can promote collateral circulation. the influencing factors on collateral circulation building have not been completely identified yet, but a recent research found that naturally occurring variants of rabep2（rab gtpase binding effector protein 2）are major determinants of variation in collateral extent and stroke severity in mice. on this basis, clinical trials have been conducted in order to confirm that the rabep2 gene is associated with individual differences in the collateral circulation. summarizing new findings, we suspect whether the difference in the degree of collateral circulation is significant for long-term prognosis in patients with cerebral large arterial occlusion, and whether promoting collateral circulation and new angiogenesis can become a new treatment approach. hereby, we plan to recruit 500 patients with cerebral large-artery occlusion, collect clinical and imaging (cta) information, analyze and investigate if the difference in the degree of collateral circulation can be the independent influencing factor for long-term prognosis. this study will collect blood sample of patients and further examine snps of rabep2, and will then analyze the correlation between rabep2 and patients with cerebral large-artery occlusion. this project will follow up rolled patients for 1 year, observe if long-term intake of butylphthalide can promote cerebral collateral development.


Eligibility criteria:
inclusion criteria: 1. patients with arterial occlusion on unilateral or bilateral intracranial segment of internal carotid artery and/or middle cerebral artery were diagnosed by cta; 2 complete medical records; exclusion criteria: 1. cta showed no arterial occlusion on unilateral or bilateral intracranial segment of internal carotid artery and/or middle cerebral artery; 2. follow-up interventional surgery; 3. death within 30 days of onset; 4. clinical data incomplete; 5. loss of follow-up patient.
glycosaminoglycans during septic shock - a temporal study

Conditions: Septic Shock

Summary: we have previously shown that the plasma level of glycosaminoglycans (gag) in septic shock patients are elevated compared to controls. the purpose of this study is to investigate the temporal dynamic of the blood level of gag in ten septic shock patients. in addition, to assess the kinetics of gag during septic shock we examine the liver function by galactose elimination capacity as well as excreted urinary gag.


Eligibility criteria:
inclusion criteria: * 2 out of 4 sirs criteria, where the circulatory criteria must be fulfilled * clinical sepsis is suspected * informed consent from relative * study subject must be over 18 years old exclusion criteria: * pregnancy * \>24h post sepsis diagnosis * ongoing oral or intravenous cortisone treatment for more than one month. * malignancy with metastasis
clinical and radiographic evaluation of guided tissue regeneration with radiation-sterilized allogenic bone grafts or xenogenic grafts for the treatment of intrabony defects in aggressive periodontitis

Conditions: Periodontitis, Aggressive

Summary: the treatment of intrabony defects in patients with aggressive periodontitis remains a challenging procedure and novel therapeutic strategies are sought. the purpose of this study is to compare the clinical and radiographic outcomes of using guided tissue regeneration (gtr) with radiation-sterilized allogenic bone grafts (material prepared in the central tissue bank in warsaw, poland) versus guided tissue regeneration with xenogenic grafts (bio-oss®, geistlich biomaterials, princeton, new jersey, united states) in the treatment of localized intrabony defects in patients with aggressive periodontitis.


Eligibility criteria:
inclusion criteria: * diagnosis of aggressive periodontitis in line with american academy of periodontology classification (lang et al. 1999) * familial aggregation (history of periodontitis in parents or siblings) * presence of at least two teeth with probing pocket depth (ppd) ≥ 6mm and clinical attachment level (cal) ≥ 5 mm associated with an intrabony defect of at least 3 mm as detected in diagnostic periapical radiographs * no furcation involvement of the teeth presenting the intraosseous defects * the width of keratinized tissue on the facial aspect of the selected teeth ≥ 2 mm exclusion criteria: * full-mouth plaque index ≥ 20% (ainamo \& bay 1975) * full-mouth sulcus bleeding index ≥ 15% (mühlemann \& son 1971) * smoking more than 10 cigarettes/day * systemic diseases with compromised healing potential of infectious diseases * drugs affecting periodontal health / healing * pregnant and lactating females * previous periodontal surgery in the area
metabolically healthy obesity: correlations between bmi and metabolic syndrome biomarkers

Conditions: Obesity

Summary: the study team's research fills the gap in the obesity literature where bmi with a cut point of 35 is frequently used to show the association between bmi and metabolic syndrome biomarkers. the study team was unable to locate any papers that showed the association between metabolic syndrome biomarkers and bmi from 35 to 69.9, and especially graphically as this clinical team has presented.

a positive association between bmi and metabolic health risk is often presented graphically as a j-shaped curve with bmi on the x-axis and the biomarker of interest on the y-axis. however, bmi is frequently presented in the literature with a cut point of 35 on the x-axis, leading to the assumption that the steep association continues beyond a bmi of 35. this presentation does not capture the metabolically healthy individual with obesity. in the population of men and women with class ii and ii obesity who the clinical team studied, it was examined that the association between bmi as a continuous variable from 35 to 69.9 and metabolic syndrome biomarkers (total-, low density, and high density cholesterol, triglycerides, systolic and diastolic blood pressure, fasting blood glucose, and glycosylated hemoglobin), the study team found no evidence for a positive correlation between bmi and tc, ldl-c, tg, and fbg. and while the study team did find positive and significant correlations between bmi and hdl-c, sbp, dbp, and hgba1c, the effect sizes were small and arguably clinically insignificant. the study team's research fills the gap in the obesity literature where bmi with a cut point of 35 is frequently used to show the association between bmi and metabolic syndrome biomarkers. the clinical team was unable to locate any papers that showed the association between metabolic syndrome biomarkers and bmi from 35 to 69.9, and especially graphically as this clinical team has presented.

Eligibility criteria:
inclusion criteria: * bmi in the range of 35 - 69.9 * men and women over age 25

Keywords: bmi obesity
mother-infant psychoanalysis project of stockholm (mipps)- follow-up at 4½ years

Conditions: Mother-child Relationship Disturbances

Summary: an rct comparing mother-infant psychoanalytic treatment (mip) with child health centre care in cases of mother-infant relationship disturbances was performed on 80 cases in stockholm 2005-2008. the infants were \< 18 months at interview #1. at 6 months follow-ups, significant effects were shown in favour of mip on maternal sensitivity (eas), depression (epds), and relationship qualities pir-gas). this study will evaluate effects at a child age of 4½ years; to evaluate the longterm effects of mip and child health centre care, and to better validate results on children who now have reached an age where they can participate more actively in evaluations.

design the 71 dyads remaining from the mipps-01 study will be interviewed when the children have reached 4½ years, in order to evaluate the long-term intervention effects of mip treatments delivered by psychoanalysts at the infant reception service of the swedish psychoanalytic society and of the usual treatments of infants and children in sweden implying contact with nurses at child health centres. instruments mother-report questionnaires; the ages and stages questionnaire:social-emotional (asq:se; squires et al., 2002), the edinburgh postnatal depression scale (epds; cox et al., 1987), the swedish parental questionnaire (spsq; östberg et al., 1997) and the strengths and difficulties questionnaire (sdq; goodman, 1997). independently rated video-taped mother-child interactions: the emotional availability scale (eas; biringen, 1998). assessment of the general functioning of the child : children's global assessment scale (shaffer et al 1983). assessment of the child's cognitive functioning: wechsler preschool and primary scale of intelligence (wppsi, wechsler, 2005). assessment of the child's social and emotional functioning: story stem attachment profile (ssap, hodges et al., 2003). machover draw-a-person test (blomberg \& cleve, 1997)

Eligibility criteria:
inclusion criteria: * the mother expressed significant concerns about one or more of the following domains: herself as a mother, her infant's well-being, or the mother-baby relationship (this was operationalized as a score \ 2.5 on the spsq). * infant of any gender, age below 18 months. * duration of worries exceeding two weeks. * domicile in stockholm. * reasonable mastery of swedish. exclusion criteria: * maternal psychosis according to dsm-iv, to an extent precluding collaboration. * substance dependence according to dsm-iv, to an extent precluding collaboration.

Keywords: mip rct postnatal depression mother-child relationship
late mesh complications after 3258 incisional hernia operations

Conditions: Incisional Hernia

Summary: the danish hernia database (dhd) registers 37 different perioperative parameters. the aim of present study is to use large-scale data from dhd to uncover risk factors for long-term (30 days postoperative and later) readmission, reoperation, death and reoperation for recurrence after incisional hernia repair with use of a synthetic mesh.

all principal incisional hernias registered in the danish hernia database are included in the study. the included patients have been followed for more than 4 years in order to identify correlation between technical aspects of the hernia repair and postoperative morbidity.

Eligibility criteria:
inclusion criteria: * incisional hernia repair

Keywords: incisional hernia complications long-term