Kornimate/medical-research-clean huggingface dataset:
use of pessary in case of cervical insufficiency and short cervix

Conditions: Preterm Labor

Summary: prematurity is the most important cause of obstetric morbidity and mortality. health centers and obstetricians are trying to reduce the preterm birth rate by taking into account the permanent effects of premature birth on human life in the early and long term. the most effective solution of preterm delivery is to determine the patients entering the risk group and to prevent preterm labor by putting the correct diagnosis at the right time. recently, there have been studies on the efficacy of pessary practice in preventing preterm birth, but with the positive results of these studies, there has been hope for early birth prevention as well as other treatments. the aim of this study is; to assess the effectiveness of pessary use in patients with high risk for preterm labor and prophylactic cervical length less than 25 mm below 25 weeks and with a history of cervical insufficiency.

the aim of this study is; to assess the effectiveness of pessary use in patients with high risk for preterm labor and prophylactic cervical length less than 25 mm below 25 weeks and with a history of cervical insufficiency. 100 pregnant women with a preterm delivery history and / or a cervical length of less than 25 mm will be included among the pregnancies between 16 and 24 weeks of gestation referred to obstetric and perinatology clinics. information will be given about the success of treatment in the prevention of early birth of the pessary and the use of the disease pessary. urine culture and cervical culture samples will be taken from both groups of patients. in the presence of infection, the patient's treatment will be planned and out of work. if no infection is detected and the patient agrees to use the pessary, the pessary will be used to prevent premature birth.

Eligibility criteria:
inclusion criteria: * patients with a cervical length of 25 mm\> and a preterm labor history in the previous pregnancy exclusion criteria: * patients with vaginal bleeding, with congenital anomalies, chorioamnionitis

Keywords: cervical pessary preterm labor cervical insufficiency
effect of atypical antipsychotic drugs olanzapine and amisulpride on glucose metabolism

Conditions: Schizophrenia; Diabetes; Insulin Resistance

Summary: patients suffering from schizophrenia have a high risk to become obese and develop diabetes. risk of obesity is particularly high with some newer schizophrenia drugs, such as clozapine or olanzapine. these drugs are called atypical drugs and exert their action in part by occupying receptors for serotonin, particularly the 5ht2a receptor subtype. this receptor may also interfere with glucose metabolism and insulin action. the purpose of this study is to compare an atypical antipsychotic drugs, olanzapine, which acts by occupying the 5ht2a receptor, to another antipsychotic drug, amisulpride, which mainly acts through the dopamine pathway. healthy volunteers are recruited and asked to take a single dose of each drug and of placebo on separate days. then, a combined glucose clamp study will be performed in order to test the effects of these drugs on insulin sensitivity and insulin secretion.

10 male healthy volunteers are recruited. after informed consent, they are admitted to the study ward at 10:00 p.m. prior to the study day and kept fasting until the next morning. at 8:00 a.m. they receive their study medication (olanzapine, amisulpride or placebo). subsequently, measurements of insulin sensitivity and insulin secretion are performed by euglycemic hyperinsulinemic clamp technique followed by hyperglycemic clamp.

Eligibility criteria:
inclusion criteria: * healthy male volunteers * written informed consent exclusion criteria: * bmi \> 30 kg/m² * diabetes mellitus * hypertension * treatment with drugs interfering with lipid or glucose metabolism (e.g. statins, oral antidiabetic drugs, glucocorticoids) * history of seizures

Keywords: schizophrenia olanzapine atypical antipsychotic drugs amisulpride diabetes insulin resistance insulin secretion glucose euglycemic hyperinsulinemic clamp hyperglycemic clamp
a study to evaluate rist4721 in familial mediterranean fever (fmf)

Conditions: Familial Mediterranean Fever

Summary: a 12-week open-label, single-arm, phase 2 study to evaluate the safety and efficacy of rist4721 in subjects with familial mediterranean fever followed by an additional open-label extension phase.


Eligibility criteria:
inclusion criteria: * diagnosis of type 1 fmf disease but no active flare at the time of screening according to tel hashomer criteria or eurofever/paediatric rheumatology international trials organization (printo) criteria for fmf * documented to be heterozygous or homozygous for at least one of the known clearly pathogenic mefv gene exon 10 mutations * males and females must be willing to use birth control as indicated exclusion criteria: * breastfeeding or pregnant * known immunodeficiency or subject is immunocompromised * active/latent infection with hbv, hcv, hiv, sars-cov-2 or tb
clinical and radiological evaluation of patients with vertebrobasilar insufficiency in assiut university hospital

Conditions: Vertebrobasilar Insufficiency

Summary: clinical and radiological evaluation including transcranial doppler of vertebral arteries of patients with vertebrobasilar insufficiency attending assiut university hospital and assessment of possible risk factors that may lead to vertebrobasilar insufficiency.

vertebrobasilar insufficiency (vbi) is defined by inadequate blood flow through the posterior circulation of the brain, supplied by the 2 vertebral arteries that merge to form the basilar artery. transient ischemic attacks in the vertebrobasilar system represent 20% of all transient ischemic attacks, their diagnosis is more difficult than that of ischemic attacks in the anterior circulation because its manifestations are subjective and difficult to quantify. although traditionally vb stroke is regarded as having a more benign outcome when compared to anterior circulation stroke, data is still conflicting, with some studies showing a higher impairment in vb stroke patients with 21% of death or major disability at 3 months. transient ischemic attacks and, more rarely, infarcts in the posterior circulation may be due to subclavian steal syndrome. basilar artery transient ischemic attacks usually occur after the six decade, syncopal attacks occur in about 10% sudden in onset and brief in duration. regarding the clinical presentation of vb stroke, the common symptoms are dizziness, unilateral limb weakness, headache, vomiting and nausea; as for clinical signs, the most frequent are unilateral limb weakness, gait ataxia, unilateral limb ataxia, dysarthria and nystagmus. previously, there was no simple and effective method for the detection of vbi, but in recent years, with the development and progress of medical technology and the emergence of transcranial doppler (tcd), it provides an accurate, noninvasive, and simple method for the diagnosis of vbi. through the diagnosis results, it will be clear about the blood flow status of single vessel and vascular compliance, which is helpful for accurate reflection of the subtle changes of vbi.

Eligibility criteria:
inclusion criteria: 1. patients with vertigo of central origin, syncopal attacks, frequent imbalance that not related to aural origin. 2. clinical examination and imaging (mri or ct) with the diagnosis standard of vertebrobasilar insufficiency including vertebrobasilar stroke and vertebrobasilar tia. 3. patients with abnormal lipogram and cervical spondylosis 4. patients aged \> 45 years old of both sex. exclusion criteria: 1. subjective complain of aural vertigo or test to exclude aural vertigo. 2. patients with malignant tumor. 3. pregnant or lactating women. 4. cognitive impairment and mental illness.

Keywords: vertebrobasilar-insufficiency-transcranial-doppler
effect of azilsartan on aldosterone in postmenopausal females

Conditions: Hypertension

Summary: the purpose of the research is to evaluate the effect of azilsartan medoximil on blood pressure and urinary aldosterone levels in postmenopausal females.

the study is a randomized, placebo-controlled trial of post-menopausal females with stage 1 hypertension. the goal is to randomize 40 post-menopausal females with stage 1 hypertension and assess whether azilsartan reduces urinary aldosterone levels. we will compare subjects having azilsartan medoximil (treatment group) with placebo group. additionally, a small sub-study comparing pre-menopausal and post-menopausal female aldosterone levels was performed as well as the presence of aldosterone production in fat cell cultures of a subset of 3 patients in the randomized trial.

Eligibility criteria:
inclusion criteria: * female * ages 45-70 * post-menopause: have not had a menstrual period for one year or more * diagnosed with stage 1 hypertension * body mass index (bmi) greater than or equal to 28 exclusion criteria: * male * diagnosed with stage 2 hypertension * stage 1 hypertension requiring more than one agent * pregnancy or attempting pregnancy * use of oral contraceptive pills * use of hormone replacement therapy * use of steroids * stage 3 or greater kidney disease * diabetes mellitus * untreated hypothyroidism or hyperthyroidism * primary hyperaldosteronism * cushing's disease * obstructive sleep apnea * chronic illness, e.g. chronic liver disease * nyha class iii or greater heart failure * moderate to severe lung disease

Keywords: post menopause female obese
upper limb reeducation across life span

Conditions: Upper Extremity Dysfunction; Dementia; Cerebral Palsy; Cognitive Decline; Eating Disorders

Summary: program ready2e.a.t. was developed to be tested in the upper limb reeducation on population at risk, such as: * children with dysfunction * cognitive impaired elderly * dementia people

program ready2e.a.t. consists on the training of specific upper limb tasks, including: * reaching during attention tasks * reaching during memory tasks * reaching during sequential motor tasks * reaching during fine hand movements this program has been tested as a measure of functional status (cognitive and motor habilities) in population with different risks; it also has been tested as an effective program for reeducation in cognitive affected population.

Eligibility criteria:
inclusion criteria: * people with 60years old with cognitive decline * children aging 6-10 years old with cognitive and motor dysfunction * dysfunction in feeding participation exclusion criteria: * participants that do not understand 2 simnultaneous verbal commands

Keywords: eating upper limb reeducation
helium oxygen mixture in the treatment of meconium aspiration syndrome

Conditions: Neonatal Meconium Aspiration

Summary: helium-oxygen mixture(heliox) was suggested to be beneficial in meconium aspiration syndrome in previous studies，but the evidence was limited．the aim of the study was to assess the effectiveness of synchronize intermittent mandatory ventilation (simv) with heliox (70% helium and 30% oxygen) on length of ventilation(lov) and cardiopulmonary protection in meconium aspiration syndrome.


Eligibility criteria:
inclusion criteria: * subject has the diagnosis of neonatal meconium aspiration syndrome * subject has synchronous instruction ventilation exclusion criteria: * history of congenital or hereditary disease

Keywords: helium oxygen mixture meconium aspiration syndrome
implementation and effectiveness of "careaide® app" for people with cardiometabolic diseases at a primary care clinic

Conditions: Hypertension; Diabetes Mellitus Type 2; Dyslipidemia

Summary: this study aims to explore the barriers and facilitators to implement careaide® app among healthcare providers and patients at a primary care clinic in malaysia. this is an implementation-qualitative research study meaning researchers will collect data regarding the adoption rate, ease of implementation and adoption, and patient's willingness to use the application. the researchers will also compare the effectiveness of the application as a tool to remind patients to take their medicine, by comparing between a group of participants who use the app and another group of participants who do not use the app. this study requires participants to use an app, then attend some routine follow-ups and be administered blood tests, followed by an interview to collect their opinions, feelings, and experiences.


Eligibility criteria:
inclusion criteria: * above 18 years old * medically diagnosed with either hypertension, type 2 diabetes and dyslipidemia for at least 6 months as listed in electronic health records * exhibit a low adherence indicated by malaysia medication adherence assessment tool (mymaat) scores of \<54 scores * taking at least one type of medication daily, three medications daily or two medications with multiple dosing intervals prescribed, * owns and able to use a smartphone * able to read english or malay exclusion criteria: * individuals who are pregnant, already using any adherence apps or diagnosed with any terminal illnesses, visually impaired, disability or mental health related illnesses
thromboelastography in non-elective cesarean delivery

Conditions: Bleeding

Summary: the purpose of the study is to assess the coagulation changes that occur in laboring patients undergoing non-elective (intrapartum)cesarean delivery using thromboelastography (teg). we will compare coagulation data to assess potential coagulation changes associated with hemoglobin changes before and after surgery, and related to estimated blood loss.

the purpose of the study is to assess the coagulation changes that occur in laboring patients undergoing non-elective (intrapartum)cesarean delivery using thromboelastography (teg). teg is a point- of-care device which measures the viscoelastic properties of clot formation. this device can provide rapid and detailed information about coagulation changes in the perioperative period. we will compare coagulation data collected from the study to assess potential coagulation changes associated with hemoglobin changes before and after surgery, and related to estimated blood loss.

Eligibility criteria:
inclusion criteria: * obstetric in-patients * laboring patients with epidurals for labor analgesia going for non-elective cesarean * patients of all ethnic backgrounds will be included * singleton pregnancy * asa 1 or 2 exclusion criteria: * patients with underlying coagulation disorders. * patients with thrombocytopenia (platelet count \<100). * patients with pregnancy-induced hypertension, pre-eclampsia. * patients requiring the following medications prior to surgery: nsaids, aspirin, anticoagulants. * patients requiring elective cesarean delivery. * patients with significant obstetric or medical disease. * no patients \<18 years of age will be recruited.
tranexamic acid in pediatric scoliosis surgery

Conditions: Scoliosis

Summary: this study aims to investigate whether intraoperative administration of tranexamic acid based on rotem® (rotational thromboelastometry), in pediatric patients undergoing scoliosis surgery, results in a difference in intraoperative blood loss when compared to the prophylactic administration of tranexamic acid.


Eligibility criteria:
inclusion criteria: * children undergoing scoliosis surgery under the age of 18 exclusion criteria: * patients with coagulation disorders * patients at an increased risk of thrombosis * patients with a history of epilepsy or brain surgery * patients with a previous allergic reaction or anaphylaxis history to tranexamic acid * severe liver or kidney impairment * other cases deemed inappropriate by the researcher
factors contribute to very late stent thrombosis after new generation des implantation in china

Conditions: Stent Thrombosis

Summary: the investigators sought to identify and verify the potential correlates and mechanisms of very late stent thrombosis (vlst) after the implantation of new generation drug eluting steng in china from an analysis of multicenter registries.

this study represents a patient-level pooled analysis of patients undergoing percutaneous coronary intervention with stent implantation for acute coronary syndrome. multiple aspects including clinical, angiographic, procedural characteristics , intravascular imaging results and blood samples were collected at index pci and the time of vlst or cag during follow-up, in order to reveal the potential mechanisms or risk factors that contribute to the development of vlst.

Eligibility criteria:
inclusion criteria: * patients\>18y,admitted for acute coronary syndrome,successfully underwent pci with at least one stent, sign informed consent. exclusion criteria: * expected lifetime was less than 1 year for any severe disease(such as tumor,severe respiratory failure et al). there is a surgical plan for important organs within 1 year after surgery and anti-platelet drugs should be discontinued. refusing to sign informed consent.died prior to discharge. poor compliance, unable to participate in regular follow-up.

Keywords: very late stent thrombosis new generation des
venous thrombosis after removal of central venous catheter

Conditions: Thrombosis, Venous

Summary: insertion of intravenous catheter is a very common operation in patients in the general intensive care unit. these catheters are used for a variety of purposes - administration of inotropics/pressors, intravenous nutrition, concentrated electrolytes and performing dialysis.there are several known complications of central venous catheter insertion, such as thrombosis and pulmonary embolism. in a literature review, there are no clear data regarding the rate of intravenous thrombosis in patients after removal of a central venous catheter. these findings are often discovered randomly, when the patient undergoes imaging for a different indication. there is no recommendation for an active search for intravenous thrombi at the catheter insertion sites in these patients, and it is not entirely clear whether it is mandatory to administer anticoagulant treatment in these patients if thrombi are randomly discovered at the catheter insertion sites. in this study, we aim to check the proportion of patients who developed thrombosis at the central catheter insertion sites after its removal, to check whether there are catheter insertion sites that are at a higher risk of developing thrombosis than other sites, and to check whether there are predictive characteristics for the development of this type of thrombosis.


Eligibility criteria:
inclusion criteria: patients who were admitted to the intensive care unit and had a central catheter inserted during their stay in the unit for any reason, and whose central catheter was removed during their stay in the general intensive care unit. - exclusion criteria:patients whose insertion or removal of the central catheter did not occur during the hospitalization in the intensive care unit, patients who were treated with full anticoagulation in the intensive care unit. -
safety and efficacy of deep wave trabeculoplasty (dwt) in primary open angle glaucoma and ocular hypertension

Conditions: Primary Open-angle Glaucoma (POAG); Ocular Hypertension (OHT)

Summary: the primary purpose of this study is to investigate the safety and efficacy of bilateral dwt in subjects with poag or oht compared to active and sham controls. the secondary purpose of the study is to investigate the durability, repeatability, and does response of the same.


Eligibility criteria:
inclusion criteria: * male or female subjects, 18 years or older. * subjects diagnosed with either poag or oht in both eyes. the diagnosis of poag must include evidence of: 1. optic disc or retinal nerve fiber layer structural abnormalities (substantiated by oct); and/or 2. visual field abnormality (substantiated with the humphrey automated perimeter using the sita standard 24-2 testing algorithm. mean deviation (md) score must be -15db \< md \< 0db. * subjects with a 9:00am (+/- 1 hour) median iop in both eyes that is: 1. greater than or equal to 18mmhg at the screening visit or have documented history of iop being greater than or equal to 22mmhg; 2. greater than or equal to 22mmhg at both eligibility visits. * subjects currently using one or more topical medications to control their iop. * subjects able and willing to comply with the protocol, including randomization assignment and all follow-up visits. * subjects that sign the informed consent form. exclusion criteria: * subjects who are pregnant, lactating, or planning to become pregnant during the course of the study. * subjects with any form of glaucoma other than primary open-angle glaucoma (e.g., pseudo exfoliation or pigmentary glaucoma). * other exclusion criteria apply

Keywords: intra-ocular pressure primary open-angle glaucoma intra ocular pressure primary open angle glaucoma glaucoma deep wave trabeculoplasty ocular hypertension
the validity and reliability study of turkish version of body perception questionnaire

Conditions: Body Image

Summary: the present study aims to determine the validity and reliability of the turkish version of the body perception questionnaire (bpq) through the turkish translation of the questionnaire and the intercultural adaptation. the body perception questionnaire (bpq) is a self-report measure of body awareness and autonomic reactivity. its items are based on the organization of the autonomic nervous system (ans), a set of neural pathways connecting the brain and body.

the present study aims to determine the validity and reliability of the turkish version of the "body perception questionnaire (bpq) through the turkish translation of the questionnaire and the intercultural adaptation. the body perception questionnaire (bpq) is a self-report measure of body awareness and autonomic reactivity. its items are based on the organization of the autonomic nervous system (ans), a set of neural pathways connecting the brain and body. these pathways send information from the body about the status of organs and tissues (i.e., afferent projections). some of these incoming signals form a basis for the subjective awareness of the body. the ans also carries signals that control the functions of these organs and tissues (i.e., efferent projections). these signals can alter the functions of the body, depending on internal and external needs. the study includes 175 healthy participants and 120 participants with anxiety. beaton's 6-step procedure was used for translation and intercultural adaptation. after the steps of the procedure were completed, the questionnaire was finalized.

Eligibility criteria:
inclusion criteria: * being a volunteer to participate in the study * being between the age of 18 - 77 * understand and follow commands * not diagnosed a psychiatric disorder exclusion criteria: * younger than the age of 18 * reported taking psychotropic drugs and/or beta-blockers * did not complete the questions * having any surgical operation in the last six months * diagnosed chronic cardiovascular, pulmonary or neuromuscular systemic disorder

Keywords: anxiety body perception questionnaire interoception validity reliability