Kornimate/medical-research-clean huggingface dataset:
study comparing the effects of spm techniques, individually vs. grouped in children with asd

Conditions: Autism Spectrum Disorder

Summary: autism is the most prevalent disorder as it affects attention, awareness, cognitive development, social development, and emotional aspects too. it is one of the comprehensive developmental disorders in the early stage, which is characterized by weak social learning and communication, limited activities, interests, learning, insufficient imaginative and stereotypical thinking or non-functional thinking of movements and verbalities. a lack of sensory perception leads to a leading autistic child\&#39;s sensitivity to sensory stimuli or weak sensitivity and the child is not aware of the surrounding environment.

the current study will be randomized control trial; data will be collected from lahore garrison institute of special education. this study will be conducted with 32 participants equally divided into two groups. inclusion criteria will be children who diagnosed with autism spectrum disorder (mild \& moderate) according to diagnostic and statistical manual of mental disorders, (dsm-5), have an iq 70 according to stanford-binet intelligence scales and be able to understand and follow instructions, children whose age between 4 to 12 and all participants had to be able to sit and walk without support according to gmfcs. exclusion criteria for the study include children who will associate with attention deficit hyperactivity disorder signs, upper limb musculoskeletal injuries, visual or auditory impairments, children who had received sensory integration therapy for \&gt; 3 months within the past 6 months and children with speech delay, hearing impairment, or intellectual disability. spm training will be given each child individually in the first group. in the second group techniques will be apply in a group therapy. the spm training programme will apply for 10 months. outcomes, including the test of movement battery for children, quality of life scale will be use. data analysis will be performed using spss version 23.00

Eligibility criteria:
inclusion criteria: * children who diagnosed with autism spectrum disorder (mild \& moderate) according to diagnostic and statistical manual of mental disorders, (dsm-5) * have an iq 70 according to stanford-binet intelligence scales * children whose age between 4 to 12 * all participants had to be able to sit and walk without support exclusion criteria: * children who will associate with attention deficit hyperactivity disorder signs * upper limb musculoskeletal injuries * visual or auditory impairments * children who had received sensory integration therapy for \> 3 months within the past 6 months * children with speech delay, hearing impairment, or intellectual disability

Keywords: autism spectrum disorder sensory perceptual motor training test of movement battery for children, dsm-5
a study on self-compassion,depression,and quality of life among primary caregivers of people with dementia

Conditions: Dementia

Summary: the goal of this observational study is to investigate the correlation between self-compassion, depression, and quality of life among primary caregivers of persons with dementia. the main questions it aims to answer are: 1. what is the current status of self-compassion, depression, and quality of life among primary caregivers of persons with dementia? 2. are there differences in self-compassion, depression, and quality of life among primary caregivers of persons with dementia based on different background variables? 3. what is the correlation between self-compassion, depression, and quality of life among primary caregivers of persons with dementia? participants will fill out the questionnaire to complete the study.

the study design of this research is cross-sectional. the participants are primary caregivers of dementia patients diagnosed by specialists, aged 18 and above, who spend 8 hours or more daily (including overnight caregivers) providing care. data is collected using instruments including the self-compassion scale, the phq-9 scale (patient health questionnaire,phq-9）, and the quality-of-life scale to investigate the relationship between self-compassion, depression, and quality of life among primary caregivers of dementia patients. the study uses independent samples t-tests and one-way anova( analysis of variance,anova) to explore differences in self-compassion, depression, and quality of life among primary caregivers of dementia patients based on different background variables. pearson correlation is used to analyze the relationships between these variables. finally, linear regression is used to predict the performance of primary caregivers of dementia patients in self-compassion, depression, and quality of life.

Eligibility criteria:
inclusion criteria: 1. primary caregivers of dementia patients diagnosed by specialists 2. aged 18 and above 3. who spend 8 hours or more daily (including overnight caregivers) providing care exclusion criteria: 1. those who do not agree to participate in the research 2. caregivers in a paid relationship with dementia patients, such as foreign domestic helpers and government-provided resident care attendant

Keywords: dementia self-compassion primary caregivers
gene therapy with gx-12 in combination with haart for the hiv-1 infected patients

Conditions: HIV Infections

Summary: the purpose of this study is to assess the safety of gx-12 gene therapy combined with haart in the hiv-1 infected patients and to investigate the efficacy with the value of plasma viral load and with cd4 counts and hiv-1 specific ifn-gamma expressed t-lymphocytes

currently, management of hiv infection and aids is mainly done by antiviral chemotherapy which inhibits reverse transcriptase or proteolytic enzyme. the haart (highly active antiretroviral therapy) has indeed succeeded extraordinary in decrease of the mortality and in increase of the life expediency of aids patients. however, there have been some significant limitations of them (for example, treatment fatigues, the side effects, the emergency of resistant, high medical costs, etc.). recently, there has been a number of bioresearch for immunotherapy to overcome these limitations of current medications. gx-12 is a genetic using a naked dna with human il-12 mutant as immune adjuvant. gx-12 is designed to vaccinate the individuals with hiv antigens, which is to result in enhancing the hiv specific immunity and to expand broadly the immune responses nonspecifically. in this study, the safety and efficacy of gx-12 will be investigated.

Eligibility criteria:
inclusion criteria: * aged between 18 and 50 years * hiv-1 type b infected but asymptomatic patient * patient who has received haart less than 6 months according to the standard management guidelines and reached to aviremia * patient with appropriate immunity (i.e., cd4 counts\>=400cells/ul and si\>3 by cd4+ t-cell proliferation in vitro assay) * patient with negative hbv and hcv * woman who is not childbearing or who has used any contraceptive at least for 3 months before study entry * patients given a written consent exclusion criteria: * patient who has received other investigational drug or who participated into other study within 30 days before this study * patient who had an experience of hypersensitivity to same drug (for example: a plasmid dna, etc) * patient who has received an immunosuppressant * patient who has received other hiv vaccine * patient who has received other interleukin(s) * patient who experienced an opportunistic infection defined as aids before this study * patient with any severe recurrent diarrhea or vomiting * patient with clinically significant acute or chronic liver dysfunction, kidney dysfunction, hematological disorder, endocrine disorder, immune disorder, heart disease, infection, etc. * patient with malignant tumor(s) * patient with alcohol or drug abuse * patient of potential harm due to drug interactions by haart * woman of pregnancy (positive pregnancy test) or beast feeding * patient who is not appropriate at investigator's discretion, not specified in above

Keywords: gene therapy gx-12 hiv-1 interleukin aids hiv-1 type b infection treatment naive
comparison of rocabado approach versus postural correction exercises on kinesiophobia and interincisal distance in patients with temporo-mandibular dysfunction

Conditions: Temporo-mandibular Dysfunction

Summary: temporo-mandibular dysfunction can cause pain and tenderness of jaw so posture correction exercises and rocabado exercises will be performed targeting jaw opening and kinesiophobia.

temporo-mandibular dysfunction refers to pain in area of temporo-mandibular joint and masticatory muscles.temporo-mandibular dysfunction can cause pain or tenderness of jaw and aching pain in and around the ear along with difficulty in chewing.in addition to these symptoms the temporo-mandibular dysfunction results in impairment of mouth opening. so the posture correction exercises and rocabado exercises will be used to treat patients which will target jaw opening and kinesiophobia.

Eligibility criteria:
inclusion criteria: * male and female of 18 to 45 years with tmd pain for less than six months and pain rating at least moderate in severity * must not be receiving any treatment for tmd at the onset of the study (for example, an occlusal splint, prescription medication) * pain must have been of masticatory muscle origin * pain on jaw movement, headache and referred pain are suggestive of a muscular problems. exclusion criteria: * patients of systemic rheumatic disease \& fibromyalgia * dental pathology * orofacial pain disorders * cervical structural pathology * current use of analgesics more than 3 days per week * current use of narcotics, hypnotic drugs, sedatives, or muscle relaxants
the effect of acupoint application combined with ear acupoint embedding in patients after esophageal cancer surgery

Conditions: Traditional Chinese Medicine

Summary: to study the effect of acupoint application combined with ear acupoint seeding on the discomfort symptoms of nasal catheter in patients after esophageal cancer surgery

from january to december 2021, 200 patients after esophageal cancer surgery with nasal catherterization in an affiliated hospital of soochow will be selected as the research objects, and they will be divided into experimental group (100 cases) and control group (100 cases) by random number table method. the control group will receive routine nursing care, and the experimental group will implement a precision nursing program of acupoint application combined with ear acupoint embedding on the basis of the control group. the thirst, throat pain, comfort, sleep, and unplanned extubation rate will be compared between the two groups.

Eligibility criteria:
inclusion criteria: meet the diagnostic criteria for esophageal cancer; age 50-70 years old; undertake radical surgery for esophageal cancer, and place a tube through the nose after surgery; the patient communicates well with no cognitive impairment; informed consent for this study, signed informed consent . exclusion criteria: patients undergoing mechanical ventilation after surgery; serious complications and death after surgery; patients with external ear diseases and skin damage; participating in other clinical research projects.

Keywords: acupoint application ear acupoint embedding esophageal cancer surgery unplanned extubation thirst thore throat comfort sleep
sperm banking among adolescents newly diagnosed with cancer: development of a profiling and referral tool

Conditions: Cancer

Summary: despite the known adverse effects of specific cancer treatments on fertility, only 18-26% of at-risk adolescents and young men cryopreserve sperm prior to cancer treatment in the us: these already less than optimal rates of sperm banking are even lower among adolescents who have increased anxiety at cancer diagnosis, are lower in age and socioeconomic status, of evangelical religious orientation, or are diagnosed with leukemia/lymphoma: it is not clear why sperm banking is underutilized, particularly in light of the high priority that survivors of childhood cancer place on fertility and the high psychological distress associated with fertility loss. studies addressing sperm banking among adults with cancer suggest that factors such as poor physician communication and the resulting lack of fertility-risk knowledge by patients contributes to the low frequency of sperm cryopreservation. no well-designed studies have examined risk factors associated with failure to bank sperm among adolescents with cancer, a developmentally distinct population ripe for intervention. this study plans to enroll 206 adolescent males and 412 parents/guardians.

this study will identify factors predictive of sperm banking/not sperm banking in order to design interventions for increasing fertility preservation among adolescent males newly diagnosed with cancer. specifically, this study aims to investigate psychological, demographic, developmental, parent/guardian, provider, and medical factors predictive of sperm banking outcomes among at-risk adolescents with cancer. once these factors have been identified, the study will develop a novel profiling and referral tool. this instrument will ultimately serve as an intervention for both healthcare providers and families through the facilitation of appropriate referrals, and tailored interventions for decreasing barriers to sperm banking. finally, the feasibility of the profiling and referral tool will be evaluated based on provider and family report.

Eligibility criteria:
inclusion criteria: * male participants newly diagnosed with cancer. * patients must be between 13 years of age (≥ 13 years) and 21 years of age (\< 22 years) at time of study enrollment. * participant identified as tanner stage iii or higher. * participant identified by his oncologist (or designee) as being at risk for treatment-related infertility. * proficiency speaking and reading english or spanish. * cognitive capacity to complete study questionnaires. exclusion criteria: * participant previously treated for cancer. * history of mental retardation or severe cognitive or learning impairment.

Keywords: sperm banking adolescent males infertility adolescents diagnosed with cancer
risk factors for cut-out after internal fixation of trochanteric fractures in elderly subjects.

Conditions: Proximal Femoral Fracture

Summary: proximal femoral fracture is associated with severe morbidity and mortality and high socioeconomic costs. the main mechanical complication of internal fixation in trochanteric fracture is lag-screw cut-out through the femoral head. several factors are involved, but remain controversial. the aim of the present study was to determine risk factors for cut-out in internal fixation of extracapsular proximal femoral fracture.


Eligibility criteria:
inclusion criteria: * patients over 75 years of age * operated on for extracapsular proximal femoral fracture * after bodyheight fall exclusion criteria: * intra-capsular fractures * trochantero-diaphyseal fractures * subtrochanteric fractures * fractures involving pathological bone

Keywords: cut-out gamma nail lag-screw tip-apex distance trochanteric fracture
clinical study spartan covid-19 v2 system

Conditions: Covid19

Summary: this multicentre prospective study will enroll a sufficient number of patients to afford approximately 60 positives and \> 40 negatives (as determined by the soc - comparator method) in the united states and/or canada. one to three sites in the united states and/or canada will participate over an approximate 12-week enrolment period. the actual enrolment period will be dependent upon prevalence of covid-19. once positives sample size is achieved, expected sarc-cov-2 negative subjects will be permitted. this study is observational and will not impact the medical management of the patient. the results of the spartan test will be blinded to the clinical staff during the study and will not impact the medical management of the subject. once informed consent is obtained and eligibility is confirmed, subject demographics, and patient reported covid-19 symptoms will be recorded. for the purposes of this study, enrolment will be defined as the collection of the two study-specific nasopharyngeal (np) samples for spartan's test. each patient's active involvement in the study will last for approximately 30 minutes. to support the eua, a minimum of 30 individual natural positive clinical specimens will be collected from patients suspected of sars-cov-2 infection by a healthcare provider in covid-19 disease endemic regions in the united states. additionally, a minimum of 30 individual negative samples will also be used to support the eua from patients in the united states. once subjects are consented and recruited for the study, three nasopharyngeal samples for each patient will be collected by trained operators at the clinical site. the first sample will be tested at the clinical site according to standard of care protocols currently in place for the sites' nasopharyngeal swab-based sars-cov-2 rt-pcr testing. the second nasopharyngeal sample will be tested at the site using the spartan covid-19 v2 system. the third nasopharyngeal sample will be tested using the spartan covid-19 v2 system only when the test conducted with the second nasopharyngeal swab does not produce a positive or negative result. the sample for the soc test will be collected prior to the samples for the spartan covid-19 v2 system as per clinical regulations.


Eligibility criteria:
inclusion criteria: * individuals suspected of sars-cov-2 infection by a healthcare provider * individuals whose first symptom onset occurred less than or equal to 7 days of presentation * individual (or authorized representative) able or willing to provide written informed consent for study participation exclusion criteria: * vulnerable populations (e.g., women with pregnancy, institutionalized individual) as deemed inappropriate for study by the site investigator * individuals with self-reported nosebleed within 24 hours of presentation
post-partum haemorrhage (pph) improvement of skills with actor simulations

Conditions: PPH - Postpartum Hemorrhage

Summary: pre test and post test questionnaire for evaluation of skills and teamwork capacities in pph management

obstetricians, midwives, anesthesiologists, surgical theatre nurses, and sanitary collaborators are enrolled voluntary in a teamwork (2 gynecologists, 2 midwives, 1 anesthesiologist, 1 surgical theatre nurse, and 1 sanitary collaborator) for managing a pph scenario. 2 different teamworks will attend a frontal lecture of 30' and afterwards they attend a scenario with actors/facilitators (enrolled within obgyn residents) or attend a scenario with a high-fidelity mannequin after a questionnaire indicating previous experiences and skills (at the end they accept video recording of the scenario and the use of data for scientific reasons). the teamwork is recorded and an extensive debriefing is conducted using the video records and a dataset indicating positive and negative approach. after they will answer a questionnaire indicating the use of this scenario and indicating how it is compared to reality. personal approach to teamwork job is also described.

Eligibility criteria:
inclusion criteria: * personnel working in labour ward and surgical theatre * volunteers exclusion criteria: * none

Keywords: pph actor scenario improve skills improve teamwork reactions
effects of insulin resistance in non-diabetic acute coronary syndrome patients

Conditions: Insulin Resistance

Summary: effects of insulin resistance in non-diabetic acute coronary syndrome patients by the homeostasis model assessment index (homa2-ir)

help patients know about insulin resistance. if this condition persists for a long time, it will reduce the ability to produce insulin, thereby leading to increased blood sugar levels, causing type 2 diabetes. helping doctors have a more general view, in order to come up with a strategy more effective monitoring and treatment, preventing diabetes and cardiovascular events.

Eligibility criteria:
inclusion criteria: * control group the researcher collected samples from healthy people over 18 years old who came for a health check and were concluded to have good health at the health examination department of university of medicine and pharmacy hospital, ho chi minh city. not falling within the exclusion criteria and agreeing to participate in the study were included in the study. * researchers -all patients diagnosed with acute coronary syndrome who were over 18 years old, met the inclusion criteria and did not have exclusion criteria, and agreed to participate in the study were included in the study. exclusion criteria: * control group * patients \< 18 years old. * history of heart disease or stroke * exclude diabetic subjects * exclude subjects at high risk of insulin resistance * researchers * have diabetes or have previously been diagnosed with diabetes. * patients \< 18 years old. * the patient does not participate in follow-up examinations and does not follow up treatment at the medical facility. * the patient died before reaching the hospital. * patients with severe medical diseases: cirrhosis, cancer, obstructive pulmonary disease chronic obstructive pulmonary disease, chronic heart failure, severe kidney failure.
impact of iron stores on wound healing in plastic surgery

Conditions: Healing Wound; Iron-deficiency; Surgical Wound

Summary: in breast reduction surgery, delayed wound healing may increase surgical site infections, cutaneous necrosis and may be related to psychological harm.some risk factors have been identified : smoking, diabetes, overweight. a normal healing involve cellular and biochemical reactions in which iron plays an important role such as cellular respiration, redox reactions and regulation of genes involved in the cell cycle. this trial will study the relationship between iron stores and postoperative wound healing after bilateral breast reduction surgery in patients without preoperative anaemia.the primary outcome of this trial is the comparison of wound healing at post operative day 15, between patients with and without iron deficiency.


Eligibility criteria:
inclusion criteria: * age \>18 years * female * scheduled bilateral breast reduction surgery * biological exams with ferritin and transferrin saturation coefficient taken the day before surgery * no anemia : haemoglobin \>=12g/dl (preoperative biological assessment ) * if genetic disease of haemoglobin, haemoglobin between 10 and 12g/dl and no anaemia by iron deficiency * absence of clinical inflammatory syndrome (no clinical signs of infection or no fever) * non-opposition of the patient to participate exclusion criteria: * anaemia by iron deficiency