Kornimate/medical-research-clean huggingface dataset:
effects of progressive resistance training vasomotor symptoms in post menopausal women

Conditions: Post Menopausal

Summary: the study will be a randomized clinical trial and will be conducted in civil hospital and kalsoom hospital samundry. this study will be completed in time duration of 10 months after the approval of synopsis. non probability convenience sampling with randomization technique will be used and 26 participants will be recruited in study after randomization. the subjects will be divided into two groups and the group a will receive progressive training and health education and group b will receive only health education. the data will be assessed at the baseline and after 8th week of treatment. after data collection data will be analyzed by using spss version 21.

the significance of this study is that it may improve the postmenopausal symptoms like depression and vasomotor symptoms which includes hot flushes , night sweats etc .in postmenopausal females. the majority of studies examining the vasomotor symptoms affected by symptoms of post menopause have concentrated on the effects of therapies like hormone therapy.to our knowledge, no studies have looked at the connection between vasomotor symptoms,depression and resistance training. without doing so, it is challenging to understand how vasomotor symptoms have an impact. this study sought to fill in the knowledge vaccum by examining the resistance training effect on depression , fatigue and vasomotor symptoms.

Eligibility criteria:
inclusion criteria: post-menopausal women with age 50 - 60 years blood pressure less than 160 / 100 more than or equal to 4 moderate-severe vasomotor symptoms including hot flushes, nocturnal sweats, sweating and poor sleep. exclusion criteria: chronic metabolic and endocrine diseases receiving hormone replacement treatment surgical menopause cognitive impairment

Keywords: depression fatigue vasomotor symptoms post-menopause
the pphgb study: non-invasive hemoglobin measurement

Conditions: Postpartum Hemorrhage

Summary: this project is a prospective observational study aimed to assess the use of non-invasive hemoglobin measurement in anticipating postpartum hemorrhage and predicting estimated blood loss. the non-invasive hemoglobin device is the radical-7 pulse co-oximeter which is a spectrophotometer manufactured by masimo, inc. participants in the study will be undergoing a cesarean delivery at the george washington university hospital and during delivery the patient will wear the device on their fingertip so that hemoglobin measurements can be continuously recorded. no changes from routine medical management will occur during the study.

this project is a prospective, observational study aimed to predict bleeding using hemoglobin trends measured non-invasively in patients undergoing elective cesarean delivery at the george washington university hospital. the primary outcome is trend in hemoglobin measurement, at which additional interventions are required to control hemorrhage. the overall goal is to be able to determine a threshold point in which a drop in the hemoglobin level indicates severe bleeding in anticipation of postpartum hemorrhage. through the observation of the continuous monitoring of hemoglobin across all participants and correlating those with severe hemorrhage to the magnitude of drop or time of drop, this could potentially optimize the hemorrhage protocol and might limit the need for blood transfusion and decrease maternal mortality and morbidity.

Eligibility criteria:
inclusion criteria: * pregnant women age 18 - 50 years old * patients scheduled for cesarean delivery at \>34 weeks gestation * patients who failed trial of labor and require cesarean delivery exclusion criteria: * patients with spontaneous or operative vaginal delivery * patients with hemoglobinopathies (qualitative defects, sickle-cell anemia) and hemoglobin synthesis disorders (quantitative defects such as thalassemia) * patients with peripheral vascular diseases and skin conditions that affect blood vessels in the digit * patients with hyperbilirubinemia

Keywords: hemoglobin
using an api to commercialize an evidence-based weight loss intervention

Conditions: Weight Loss; Health Behavior

Summary: this study will test the effectiveness of a mobile application that uses an application program interface (api) to distribute evidence-based weight loss interventions. half of the participants will receive this api-based application, and the other half of the participants will use a non api-based application.

the purpose of this study is to test a weight loss app that uses an api to disseminate an evidence-based weight loss intervention. the investigators hypothesize that, over the course of 12 months, participants using the leaner app will have lost more weight than those in the attention control group. participants (n=206) will be randomly assigned to use either the intervention app (intervention arm; n=103) or a weight loss app of their choosing (attention control arm; n=103) for 12 months. assessments will take place at baseline, and 3, 6, and 12 months. statistical analysis: a linear mixed modeling approach will be used to test the hypothesis. observed weight vs. time plots will be analyzed for all participants to discern general trends in weight change. the model will include an intervention effect, a time effect, an intervention by time interaction, and a random intercept. in exploratory analysis, investigators will examine weight change across subgroups of interest; investigators will add the subgroup variable and its interaction with the intervention indicator to the primary model. all analyses will be evaluated at the 0.05 significance level.

Eligibility criteria:
inclusion criteria: * informed consent * between 21-65 years old * bmi between 25-40 kg/m2 * ownership and use of an android smartphone during past 6 months with no plans to change phone/service during study * consent for research team to monitor app utilization exclusion criteria: * use of weight loss medication * prior or planned bariatric surgery * psychiatric hospitalization in past 12 months * pregnancy, nursing, or planned pregnancy during the study * history of cardiovascular disease (cvd) event * self-reported history of an eating disorder * use of medication for diabetes mellitus * mobility restrictions for which exercise is contraindicated * history of a condition (e.g., lithium, steroids, anti-psychotics) that would affect weight measurement, for which weight loss is contraindicated * current participation in another weight treatment study and/or recent weight loss \>10% * investigator discretion for safety reasons
a double-blind study of e5555 in japanese patients with acute coronary syndrome

Conditions: Acute Coronary Syndrome

Summary: the purpose of this study is to assess the safety and tolerability of e5555 in japanese patients with acute coronary syndrome.


Eligibility criteria:
inclusion criteria: 1. 45 - 80 years old (at time of informed consent) 2. male or female (females of childbearing potential must be contracepted) 3. confirmed acute coronary syndrome exclusion criteria: 1. unwilling or unable to provide informed consent 2. history of acquired or congenital bleeding disorder, coagulopathy, or platelet disorder 3. recent trauma or major surgery 4. evidence of active pathological bleeding at screening or history of gastrointestinal or genitourinary bleeding with unknown cause within 24 weeks prior to screening 5. history of intracranial bleeding or history of hemorrhagic retinopathy 6. history of new york heart association (nyha) class iii or iv congestive heart failure 7. pregnant or lactating women

Keywords: platelet aggregation inhibitors coronary stenosis coronary thrombosis
prophylactic phenylephrine co-administration during caesarean section

Conditions: Cesarean Section Complications; Anesthesia Complication

Summary: this single centre prospective alternating intervention study will aim to compare prophylactic phenylephrine given in the first litre of ringers lactate as co-load in healthy patients having an elective caesarean section under spinal anaesthesia at edendale hospital to the existing national protocol guideline - for the treatment of obstetric spinal hypotension.

spinal anaesthesia is currently standard of care for patients undergoing caesarean section. obstetric spinal hypotension is a common and important problem, related to important maternal and foetal outcomes. the prevention and treatment of spinal hypotension has been well researched in resource-rich settings, a context different from that encountered in the south african setting. it has been previously shown that a prophylactic phenylephrine infusion is effective in resource-limited settings, but this method is still dependent on the availability of an infusion pump.the ideal dose offering the best risk to benefit profile is 25 to 50 mcg/min. it has recently been shown that a prophylactic phenylephrine infusion, administered by an infusion pump, appears safe and effective in resource-constrained environments. however, some institutions in south africa are limited by a lack of available infusion pumps. there is an urgent need to translate these research findings into a pragmatic management strategy that is safe and effective where this equipment is lacking. a 18g jelco allows flow of approximately 100 ml/min in the absence of a pressure bag: therefore with 500 mcg in 1000 ml of ringers lactate and a fully opened line, a maximum dose of 50 mcg.min-1 will be achieved. if the rate is 50 ml/min (20 minutes for the first litre) the dose will be 25 mcg.min-1. this dose range will offer maximum benefit with low risk of side effects. this exploratory study will establish if a phenylephrine (500 mcg) bolus, added to the first litre of ringers lactate given as a co-load, is an effective and safe means to prevent post obstetric spinal hypotension. this regime will be compared to the existing south african national protocol of the management of obstetric spinal hypotension. the findings of this study will provide valuable information regarding a safe and potentially effective means to prevent obstetric spinal hypotension.

Eligibility criteria:
inclusion criteria: * all asa 1-2 patients undergoing elective caesarean exclusion criteria: * asa grade \>2 hypertensive disease in pregnancy dysrhythmia failed spinal requiring conversion to a general anaesthetic
fatigue, depressive disorders and insomnia in adult patients with marfan syndrome and ehlers-danlos syndrome: survey

Conditions: Rare Diseases; Fatigue; Insomnia; Depression

Summary: the goal of this observational study is to describe and assess the presence of perceived fatigue in subjects with mfs and eds. the main question it aims to answer through the fss instrument is: * the relationship of fatigue with physical and psychological characteristics, the presence of depressive disorders and insomnia.

marfan syndrome (mfs) and hypermobile ehlers-danlos syndrome (heds) are rare diseases of the connective tissue presenting peculiar symptoms as well as high mortality due to complications related to dilatation and dissection of the ascending aorta and great arteries. life expectancy of patients with mfs and heds has improved markedly in the last decades, but still remains lower than that of the general population. fatigue represent one of the main causes that limit the quality of life in these populations. the fatigue severity scale (fss) is a questionnaire widely used in populations with chronic diseases and has been previously applied in mfs and heds population: indeed, fatigue interferes with activities of daily living and the presence of chronic pain. however, the potential correlations that fatigue may have with different aspects of psychological well-being (i.e. insomnia and depression) were not investigated in mfs and heds.

Eligibility criteria:
inclusion criteria: * subjects aged 18 or greater with clinical and/or genetic diagnosis of marfan syndrome; * subjects aged 18 or greater with clinical and/or genetic diagnosis of hypermobile ehlers-danlos syndrome; * signed informed consent; * ability to speak, read and write in italian.

Keywords: marfan syndrome ehlers-danlos syndrome fatigue survey
can post-operative tap block improve quality of recovery after c-sections in patients on methadone maintenance?

Conditions: Uncontrolled Postoperative Pain

Summary: this is a prospective randomized double-blind placebo controlled study (0.375% ropivacaine vs. 0.9% saline) designed to evaluate the effectiveness of transverse abdominis plane (tap) block in the first 48 hours after c-section in patients receiving methadone therapy. the tap block will be performed by a regional anesthesiologist in the operating room after delivery of the baby.

introduction: cesarean sections are the most common surgical operations performed in the u.s (1). patients requiring c-section who are on methadone maintenance often have uncontrolled pain due to opioid tolerance. the current treatment is to utilize large amounts of opioids via pca thus resulting in a challenging situation with poor patient satisfaction. the transversus abdominis plane (tap) block has been studied with success in many abdominal surgeries including c-sections (2-5). the anterior abdominal wall is innervated by anterior divisions of spinal segmental nerves which lie between the transversus abdominis and internal oblique muscle layers. blockade of these nerves with local anesthetics may last up to 24 hours. there have been no efficacy studies performed using the tap block in patients receiving chronic methadone maintenance undergoing c-sections. methods: this is a prospective randomized double-blind placebo controlled study (0.375% ropivacaine vs. 0.9% saline) designed to evaluate the effectiveness of transverse abdominis plane (tap) block in the first 48 hours after c-section in patients receiving methadone therapy. the tap block will be performed by a regional anesthesiologist in the operating room after delivery of the baby. objective: the primary objective of this study is to measure pain levels after c-sections in patients receiving methadone therapy utilizing visual analog scale (vas) and assessing opioid consumption during the first 48 hours compared to placebo. conclusion: it is hypothesized that patients receiving tap block will have decreased pain intensity and less opioid consumption during the first two postoperative days compared to placebo. therefore we believe postoperative tap block to be an effective adjuvant to pain control for patients on methadone maintenance following c-section.

Eligibility criteria:
inclusion criteria: * laboring patients will only be enrolled in the study if they have a c-section performed. inclusion criteria include patients who are 18-40 yr of age, asa physical status i-iii, 50-100 kg, 150 cm tall or greater, and english-speaking exclusion criteria: * patient refusal, methadone use for chronic pain, contraindications to administration of regional anesthesia (e.g., allergy to a local anesthetic, local infection and coagulopathy), significant neurologic disorders of the lower extremity, and psychiatric or cognitive disorders.
evaluation of the right ventricular systolic function using real-time three-dimensional echocardiography in intensive care unit patients

Conditions: Ventricular Dysfunction, Right; Lung Diseases; Intensive Care Units

Summary: right ventricular failure (rvf) is an independent factor of mortality for many pulmonary diseases. currently, rvf is defined as the incapacity of the rv to maintain the flow without dilating to use the frank-starling law (i.e., increase of the ejection volume associated to an increase of the preload). rvf is associated to rv systolic dysfunction which is conventionally defined as a decrease of the rv ejection fraction (rvef) \< 45%. in the intensive care unit (icu), acute rvf is mainly due to the acute respiratory distress syndrome (ards), sepsis or septic shock, and less often to severe pulmonary embolism or rv infarction. the anatomical complexity of the rv precludes any geometrical assumption to estimate its volume, hence its ejection fraction (ef) using two-dimensional (2d) echocardiography. for this reason, the evaluation of rv systolic function is currently based on parameters used as surrogates of rvef: fraction area change in 2d-mode, tricuspid annular plane systolic excursion (tapse) in m-mode, and maximal velocity of the systolic s' wave using tissue doppler imaging. real-time three-dimensional (3d) echocardiography now enables accurate on-line measurement of rv volume and provides at the bedside the non-invasive assessment of rvef. 3d transthoracic echocardiography (tte) has been validated to measure rv volume and rvef compared to mri which is the gold standard. however, 3d transesophageal echocardiography (tee) has not yet been validated in this specific clinical setting, while 2d tee is frequently used in icu in ventilated and sedated patients. accordingly, the diagnostic ability of 3d echocardiography to quantify rv systolic function in icu patients with rvf of any origin is currently unknown.


Eligibility criteria:
inclusion criteria: 1. adult patients (≥ 18 years old) hospitalized in the icu and requiring echocardiography for any reason 2. with a disease at risk of being associated with rvf: * ards (berlin definition) * sepsis or septic shock (sepsis-3 definition) * pulmonary embolism * rv infarction 3. affiliated to social security 4. consent of the patient and/or his authorized representative to participate in the study. exclusion criteria: 1. history of congenital cardiac disease 2. patient under legal protection 3. under any method of oxygen support or extracorporeal circulatory support (veno-venous extracorporeal membrane oxygenation, extracorporeal life support...) 4. non sinusal rhythm 5. documented preexisting right cardiac disease 6. quality of echocardiographic images incompatible with 3d assessment.

Keywords: right ventricular failure lung diseases intensive care units
postoperative recovery after thoracic surgery

Conditions: Postoperative Pain; Postoperative Complications

Summary: a questionaire specifically developed using in depth interviews with patients that has undergone surgery has been developed. this questionaire will be used for longterm follow in patients undergoing thoracic surgery. 200 patients will be asked to fill in this questionaire preoperatively as well as 3 and 12 months after surgery to assess symptomburden after surgery with specific aim to study postoperative pain as well as other physical, mental and cognitive problems that may affect the patient and their daily activities, health, return to work, family life and economy.

in sweden around 400 000 patients under go surgical operations in hospitals. a large proportion, around 20%, develop persistent postoperative pain which affects their quality of life and their recovery towards a normal life. a questionaire specifically developed using in depth interviews with patients that has undergone surgery has been developed. this questionaire will be used for longterm follow in patients undergoing thoracic surgery. 200 patients will be asked to fill in this questionaire preoperatively as well as 3 and 12 months after surgery to assess symptomburden after surgery with specific aim to study postoperative pain as well as other physical, mental and cognitive problems that may affect the patient and their daily activities, health, return to work, family life and economy.

Eligibility criteria:
inclusion criteria: patients undergoing thoracic surgery (thoracotomy or thoracoscopy) who accept to participate in the study exclusion criteria: none
fecal microbiota transplantation for refractory iga nephropathy

Conditions: IgA Nephropathy

Summary: iga nephropathy (igan) is one of the most common glomerular diseases worldwide. current treatments for igan are limited by their relatively insufficient efficacy and severe adverse events. previous studies suggested that the disorder of intestinal flora may play an important role in the pathogenesis and prognosis of igan. fecal microbiota transplantation (fmt) have been proved to be effective on rebuilding the intestinal microecological balance. however, there is no evidence for the safety and efficacy of fmt in igan. therefore, investigators perform a prospective cohort study to evaluate the safety and efficacy of fmt in igan patients who did not response to the conventional treatment and did not want to aggravate immunosuppressive treatments or igan patients who did not response to immunosuppressive treatments.


Eligibility criteria:
inclusion criteria: * adult, age: 18-65 years old. * pathological diagnosis with igan, egfr：20-120 ml/min/1.73 m2. * the 24-hour urinary protein was still greater than 1g after 3-6 months of treatment of acei/arb * recurrence of igan after glucocorticoid and (or)immunosuppressant decrement and the 24-hour urinary protein was greater than 1g. * not suitable for the administration of glucocorticoid and (or) immunosuppressive agents because of side effects. * women of child-bearing age with negative urine pregnancy test have no pregnancy plan for the next 18 months and take effective contraceptive measures. * agree to participate in this clinical trial exclusion criteria: * malignant tumors and other diseases with expected survival time \<3 months. * severe cardiovascular and cerebrovascular diseases and pulmonary dysfunction. * other immune system diseases. * diabetes * inflammatory bowel disease（ibd） * clostridium difficile infection * gastrointestinal tumor * active gastrointestinal bleeding * acute and chronic gastroenteritis * have received or are receiving fmt treatment. * hiv * psychosis and dysgnosia * contraindication of colonoscopy and enema * alcohol/drug abuse * other conditions that the researchers thought were not appropriate for the group.

Keywords: iga nephropathy fecal microbiota transplantation