Kornimate/medical-research-clean huggingface dataset:
observation of the comfort and efficacy of co2 laser combined with cryo 6 for burn or linear scars.

Conditions: Cryotherapy Effect; Burn Scar; Scar; Previous Cesarean Section

Summary: to investigate the effect of 10,600 nm co2 laser combined with zimmer cryo 6 forced cold air device on the comfort and efficacy of patients with burn scars or post-operative linear scars, and to provide a safer, more effective and more satisfactory program for clinical treatment of burn scars or post-operative linear scars.

objective: to investigate the effect of 10,600 nm co2 laser combined with the cold-air cooling device zimmer cryo 6 on the comfort and efficacy of patients with burn scars or post-operative linear scars, and to provide a safer, more effective and more satisfactory program for clinical treatment of burn scars or post-operative linear scars. secondary objective: to investigate the adverse effects of the cold-air cooling device zimmer cryo 6 in combination with the 10,600 nm co2 fractional laser treatment for patients with burn scars or post-operative linear scars.

Eligibility criteria:
inclusion criteria: 1. age 14-60 years; 2. the patient agreed to participate in the experiment and signed the informed consent by himself/herself or his/her legal representative; 3. the clinical diagnosis was burn scar or post-operative linear scar, and the total area was more than 5 cm2. 4. no other treatment such as laser or chemical exfoliation was performed on the lesion within the recent half year. 5. skin lesions were free of bleeding, ulceration, infection and other conditions affecting the visual field of laser treatment. exclusion criteria: 1. patients with an active or established sun tan; 2. patients with history of allergic reaction to to topical anesthesia; 3. patients with history of keloid scarring, abnormal wound healing and/or prone to bruising; 4. skin malignant tumors or precancerous lesions; 5. patients with diabetes, heart disease, epilepsy, connective tissue disease, etc.; 6. pregnant or breastfeeding patients; 7. patients with recent skin infections (such as viral and bacterial infections); 8. patients who are using other methods to treat similar diseases; 9. patients who had taken isotretinoin within the past year; 10. history of cryoglobulinaemia; 11. history of cold agglutinin disease and cold haemolysis; 12. history of cold urticaria; 13. parts of the body with impaired circulation; 14. raynaud's disease; 15. parts of the body with impaired sensitivity; 16. trophic disorders; 17. hypersensitivity to cold; 18. patients with mental illness; 19. other ineligible patients.
inhaled treatment for bronchopulmonary dysplasia

Conditions: Bronchopulmonary Dysplasia

Summary: the primary objective of this study is to provide expanded access of s-nitrosylation therapy for the treatment of bronchopulmonary dysplasia

open label study with 20 participants, open-label, with block dose escalation of 3 subjects/dose (0.5 ml/kg of 0.25 mm, 0.5 mm, or 1 mm). a minimum of seven days of surveillance will separate dosing blocks. an additional 11 subjects will be enrolled at the maximum 1 mm block (5x10-7 moles/kg). the primary outcomes are safety during 30 minutes of inhalation, and for 4 hours after inhalation, as measured by occurrence of adverse events related to the treatment + time period \[during administration and tracked for next 7 days\].

Eligibility criteria:
inclusion criteria: 1. inborn or outborn infants of either sex or any race or ethnicity 2. \<32 weeks gestation at birth (best obstetrical dating) 3. aged 29 to 365 days 4. refractory hypoxic respiratory failure (average daily fio2 \>35% for 5 days) 5. requires mechanical ventilation via endotracheal airway exclusion criteria: 1. life-threatening congenital or acquired anomalies (lethal chromosomal, thoracic/cardiac, brain) 2. unstable condition defined as severe hypoxemia (fio2 \>85% for \>24hrs), sepsis, or hypotension 3. baseline methemoglobin \> 3%, congenital methemoglobinemia, or a familial hemoglobinopathy 4. on steroid to facilitate endotracheal extubation 5. individuals on inhaled nitric oxide, a phosphodiesterase 5 (pde-5) inhibitor, taking allopurinol, β-adrenergic blockers, tricyclic antidepressants, meperidine (or related cns agents), or nitrates 6. thrombocytopenia defined as \<50,000 platelets/µl on weekly nicu labs, clinical evidence of bleeding, on an anti-coagulant, or individuals with an inherited or acquired coagulation disorder 7. anemia defined as a hemoglobin of \< 9 mg/dl on weekly nicu labs 8. concerns for pre-existing liver damage defined as an ast/alt \> 50 iu/l or direct bilirubin \>1 mg/dl on weekly nicu labs 9. concerns for acute kidney injury defined as a serum creatinine \> 0.7 mg/dl on weekly nicu labs or 24-hr urine output \<1.0 ml/kg/hr during preceding 4 days 10. patients that are ventilated with a device not certified for blending of aerosolized solutions into the ventilator circuit 11. physician of record opposed to enrolling the patient due to perceived safety concerns; or any condition that does not allow the protocol to be followed safely 12. subjects that have experienced cardiac arrest with cpr for longer than 30 minutes

Keywords: bronchopulmonary dysplasia respiratory failure
polyphenol rich supplementation on markers of recovery from intense resistance exercise

Conditions: Muscle Soreness

Summary: strength training is commonly used as an intervention to increase muscle mass, thus improving a person's ability to undertake activities of daily living, or enhance athletic performance. the strength training regimen itself, while ultimately having beneficial effects, causes muscle fibers to be damaged, which the body has to recover from. as the body recovers, it rebuilds the muscle tissue and after multiple consecutive bouts of strength training, the muscle eventually becomes larger and stronger. thus, it is the recovery from strength training exercise that ultimately determines how well the body adapts. where inadequate recovery could eventually lead to overtraining and/or injury, optimizing the recovery process from strength training could maximize strength training adaptations. this concept of optimizing recovery has led to development of many supplements, including antioxidants, which may reduce the damage associated with strength training activities and therefore enhance positive adaptations. the purpose of this study is to assess the ability of a polyphenol rich supplementation to aid the recovery process from a demanding bout of resistance exercise


Eligibility criteria:
inclusion criteria: * 6 months of resistance training experience with barbel back squat exercise exclusion criteria: * not currently taking any antioxidant supplements, not currently using any hormone replacement therapy or anabolic androgenic steroids.

Keywords: polyphenol rich supplementation tart cherry lifting recovery
a study of subcutaneous mircera, versus no erythropoiesis-stimulating agent (esa) therapy, in the treatment of anemia in patients with chronic kidney disease after kidney transplant

Conditions: Anemia

Summary: this 2 arm study will assess the efficacy, safety and tolerability of subcutaneous mircera, versus no esa therapy, in chronic kidney disease patients with anemia after kidney transplant, not currently treated with esa. patients will be randomized to receive a)subcutaneous mircera at a recommended starting dose of 0.6 micrograms/kg every 2 weeks, switching to monthly treatment at week 16 or b)supportive treatment (eg. iron supplementation) for management of low hemoglobin concentrations. the anticipated time on study treatment is 3-12 months, and the target sample size is 100-500 individuals.


Eligibility criteria:
inclusion criteria: * adult patients, \>=18 years of age; * kidney transplant \>=6 months and \<5 years prior to randomization; * anemia; * no esa therapy during 3 months prior to randomization. exclusion criteria: * requirement for hemodialysis or peritoneal dialysis within 3 months prior to randomization; * change in hb concentration \>=1.5g/dl during screening period; * transfusion of red blood cells during 3 months prior to randomization; * poorly controlled hypertension; * significant acute or chronic bleeding within 3 months prior to randomization.
functional exploration of cartilage in patients with osteoarthritis of the knee through mri sodium ( 23na )

Conditions: Osteoarthritis

Summary: osteoarthritis is a degenerative disease of hyaline cartilage not associated with an infection or an inflammatory process that affects millions of people. the first symptoms usually appear from 40-50 years and at this point, conventional radiological tests provide diagnostic elements relatively late, poorly correlated with pain relief and providing no functional information. in this context, there is a real need for imaging techniques for early detection of osteoarthritic changes in a still reversible stage for faster support and mri appears to be the tool of choice. conventional proton mri sequences already allow improved detection possibilities compared to conventional radiology and ct arthrography supplanted. they nevertheless remain insufficient to identify incipient lesions or paradoxically to the point of too advanced lesions. due to recent technological advances, exploration mri other nuclei such as sodium is now possible. quantitation of sodium in the cartilage by sodium mri allow quantifying proteoglycan loss and ultimately a gradation osteoarthritic reached. this project's main objective is to quantify the biochemical changes (sodium content) occurring at different stages of osteoarthritis defined by clinical algofunctional scores (lequesne) and conventional radiographic scores (kellgren and lawrence).


Eligibility criteria:
inclusion criteria: * patient with osteoarthritis exclusion criteria: * patient with contraindication for mri
a study using botulinum toxin type a in patients with axillary hyperhidrosis

Conditions: Hyperhidrosis

Summary: this is a three-year study in subjects with axillary hyperhidrosis involving injection of botulinum toxin type a into the axilla to reduce sweating.


Eligibility criteria:
inclusion criteria: * marked axillary hyperhidrosis exclusion criteria: * previous use of botulinum toxin for hyperhidrosis

Keywords: axillary hyperhidrosis
flt-pet/dw-mri for detection of brain metastases and early therapy evaluation in patients with small cell lung cancer

Conditions: Small Cell Lung Cancer

Summary: the purpose of the study is to determine the value of flt-pet early after initiated chemotherapy in patients with small cell lung cancer, and to determine whether mri of the brain should be performed routinely in these patients.


Eligibility criteria:
inclusion criteria: * biopsy proven small cell lung cancer * referred for standard chemotherapy * oral and written informed consent exclusion criteria: * metal or electronical devices in the body not compatible with mri of brain or thorax * pregnancy or lactation * communication difficulties
effect of exercise on patients with claudication undergoing surgery

Conditions: Intermittent Claudication; Peripheral Arterial Disease

Summary: title: how does exercise improve the calf muscle in patients with poor blood supply to their leg? purpose of the project: patients with peripheral arterial disease have a poor blood supply to their lower leg. the reduced inflow prevents the leg from utilising nutrients and oxygen as easily as a healthy leg would. this causes pain when walking (intermittent claudication), which often occurs after a reproducible distance e.g. every 50 yards. these patients have a reduction in their quality of life as they feel embarrassed in social situations e.g. walking around town requires multiple breaks, so they tend to avoid this and isolate themselves more. one treatment for claudication is exercising until the pain comes on; which most are reluctant to do. walking up to three times a week for an hour, can double most people's walking distances, but doesn't always. the reason why some improve with exercise and others do not remains unknown. this project will be the first randomised controlled trial of exercise in claudicants that focuses on the adaptations that occur in the muscle at a cellular level. we wish to compare muscle cells from a group that have exercised and group that have not. we will focus on the change in muscle cell size and function at present, and later progress to why and how this happens. methods: we will take measurements at the start of the study (baseline), after 6 weeks and then 3, 6 and 12 months. these measurements will be of a patient's fitness, actual walking distances and blood samples. at the time of surgery, muscle from the calf will be taken from the affected leg. this will be processed at the university's biomedical science department to look at the different types of muscle fibre and how efficiently they are working.


Eligibility criteria:
inclusion criteria: * community dwelling older adults aged 45 and over * diagnosis of intermittent claudication - abpi \< 0.9 with symptoms in keeping with intermittent claudication * undergoing surgery for claudication * ability to walk without assistance * healthy control patients who are undergoing varicose vein surgery exclusion criteria: * participants who are unable to provide informed consent * severe of acute cardiovascular, musculoskeletal or pulmonary illness * critical limb ischaemia * active treatment for cancer * rheumatoid arthritis or any patient receiving steroids or disease modifying antirheumatic drugs (dmards) * failure to complete a cpet

Keywords: intermittent claudication endothelial function cardiopulmonary testing inflammation muscle architecture
an electronic shared decision-making application to improve asthma outcomes

Conditions: Asthma

Summary: this study will increase knowledge about the feasibility and effect on patient satisfaction and clinical outcomes of using an electronic shared decision making (sdm) application (app) for patients with asthma in the allergy/immunology clinic visit setting. sdm is defined as an approach where clinicians and patients share the best available evidence when faced with the task of making decisions, and where patients are supported to consider options and make informed choices.


Eligibility criteria:
inclusion criteria: * english speaking * diagnosis of persistent asthma * have an in-person visit or telehealth encounter at the allergy/clinical immunology clinics participating in this study exclusion criteria: * diagnosis of intermittent asthma * any other lung disease * smoking greater than 20 pack years or current smoking * mental impairment such that participation would not be possible

Keywords: asthma shared decision making sdm
effect of low power laser in tooth pain modulation caused by irreversible inflammation

Conditions: Pulpitis; Acute Pain

Summary: anxiety, pain and discomfort are common stressful situations that occur during the dentistry practice, especially in the urgency endodontic practice. studies have concluded that low intensity laser therapy is effective in treating pain. however, most studies have reported the low intensity laser therapy in chronic pain, few studies have shown its application on acute pain and none have evaluated the low intensity laser´s analgesic effect in acute pain of the pulp inflammation. since the pulp tissue has the peculiar characteristic to be surrounded by dentin, in acute pulpits, the inflammatory reaction is more complicated than usual. furthermore, during the inflammatory process, sometimes anesthesia is not always completely effective. thus, this present study aims to evaluate whether previous therapy with low intensity laser could, by its analgesic effect, promote greater comfort especially to this type of patient. 60 patients with acute pulpits pain will be selected to this study (randomized and double-blinded) and they will be divided in 4 groups: group 1 ( n=15) - control group; group 2 (n=15) - laser 1: 780 nanometers (nm); 40 milliwatts (mw); 4 seconds per point; 0.16 joules/point; total irradiated points: 02; group 3 (n=15) - laser 2: 780nm; 40 mw; 40 seconds per point; 1.6 joules/point, total irradiated points: 02; group 4 (n=15) - placebo group - sham laser irradiation. the pain will be evaluated by a visual analogue scale (vas) in 3 different times: initial pain, pain immediately after and 15 minutes after interventions (laser irradiation, or sham laser irradiation). after that, patients with acute pulp irreversible inflammation will be submitted to conventional endodontic urgency treatment. data concerning the need of complimentary local anesthesia will be also taken into account. data of different groups and times will be statistically compared.


Eligibility criteria:
inclusion criteria: * patients with acute pain due to irreversible inflammation of the a vital pulp tooth exclusion criteria: * non-intact pulp chamber * necrotic pulp

Keywords: low power laser pulpitis pain
chlorhexidine versus betadine in preventing colonization of femoral nerve catheters after total joint arthroplasty (tja)

Conditions: Infection

Summary: continuous femoral nerve block (cfnb) techniques continue to be increasingly used in the management of postoperative pain after total knee arthroplasty. although the risk of full blown infection with cfnb has been poorly defined, the rate of catheter colonization after antisepsis with povidone-iodine has been demonstrated to be high (cuivillion et al. showed the rate of colonization to be 57% after 48 hours). recently, several anecdotal case reports have demonstrated severe infectious complications including psoas abscess and necrotizing fasciitis associated with continuous nerve block techniques. as the use of cfnb techniques increase in popularity, infectious complications will undoubtedly become more common. the american society of regional anesthesia and pain medicine recommends the routine use of antiseptic solutions with an alcohol base for skin disinfection before peripheral regional techniques due to their penetration of the stratum corneum and their rapid and prolonged effect. chlorhexidine(chloraprep) has been proven to be better than povidone iodine solution for skin preparation before epidural catheter and intravascular device insertion (kinirons et al., ostrander et al., mimoz et al.,). the goal of this prospective trial therefore is to determine if an alcoholic solution of 0.5% chlorhexidine is more effective than an aqueous solution of 10% povidone-iodine in reducing catheter colonization and reducing skin flora associated with short term ( 48 hours) postoperative continuous femoral nerve catheter placement. the investigators will also compare the ability of chloraprep and betadine disinfection at the time of catheter placement to prevent bacterial contamination of the continuous femoral catheter.

after antisepsis four different cultures will be analyzed: 1. the femoral nerve catheter will be removed after 48 hours and a culture of the distal tip of the femoral nerve catheter will be performed between the 2 arms. 2. immediately before skin antisepsis, a culture of the the skin will be performed to identify baseline skin flora. 3. immediately after antisepsis with both betadine and chlorhexidine, a culture of the skin will be performed to assess antiseptic efficacy. 4. just prior to removal of the femoral nerve catheter, a culture of the skin/catheter interface will be performed between the 2 arms.

Eligibility criteria:
inclusion criteria: * asa 1-3, * undergoing primary total knee arthroplasty. exclusion criteria: * hypersensitivity/allergy to antiseptics, * recent opioid/alcohol abuse, * presence of contraindications to regional anesthesia, * coagulation disorder, * diabetic/femoral neuropathy, * prior surgery to inguinal area, * patient refusal.

Keywords: chloraprep betadine colonization femoral catheter
web-based single-session intervention of mindset for improving pre-practicum anxiety and coping

Conditions: Anxiety

Summary: practicum is an essential educational component of professional training, however, the process can be challenging and sometimes frustrating, with obstacles such as the rigorous training process and mental distress. being adequately prepared to confront the challenges and difficulties in practicum is crucial for the learning outcomes and psychological well-being of social work and/or counselling trainees. at the same time, mindset is found to be a modifiable factor in intervention, which is essential in clinical psychology, therapy, prevention, and early intervention. instilling growth mindsets regarding intelligence, emotion, and failure-is-enhancing mindsets, respectively, is worthwhile in easing anxiety and stress coping. however, the existing intervention approaches lack of mindset integration, low intensity, distinctions of employees and interns, more objective and reliable outcome indictors and well-designed randomised controlled trials. using a two-arm randomised controlled trial, the proposed study will examine the efficacy of a web-based single-session intervention of mindset on intelligence, failure, and emotion (we-smile) on reducing anxiety related to practicum and improving mental health and practicum-related outcomes. a total of 117 students will be recruited from the social work and/or counselling programmes, and randomly assigned to existing pre-practicum training (training as usual, tau) or that plus the we-smile. the intervention is 45 minutes in length. participants will be assessed at three timepoints: baseline (t1), two weeks post-intervention (t2), and eight weeks post-intervention (t3). patient and public involvement is adopted in the intervention design and implementation strategies. it is expected that the we-smile group will present lower anxiety related to practicum and more positive secondary outcomes (depression, anxiety, stress, psychological well-being, learning and performance orientation, academic self-efficacy, and confidence) compared to the tau group. the intention-to-treat principle and linear-regression-based maximum likelihood multi-level models will be used for data analysis. the study will not only provide evidence on integrated mindset intervention for trainees' mental health and learning outcomes, but also benefit social work and/or counselling supervisors and programmes as an accessible module.


Eligibility criteria:
pre-practicum students in social work and/or counselling programmes are eligible. * inclusion criteria: students who 1. are about to start the practicum soon; 2. can read and write chinese; 3. consent to participate. * exclusion criteria: students who 1. do not consent to participate; 2. cannot concentrate for at least 45 minutes to complete the intervention and questionnaires; 3. have a disability or serious physical or mental illness resulting in poor condition; 4. do not participate in the practicum.

Keywords: implicit theory growth mindset social work students counselling students practicum anxiety