Kornimate/medical-research-clean huggingface dataset:
reliability and validity of the turkish version of smi̇le-c

Conditions: Covid19

Summary: how the life style changed multidimensionally with home isolation in the period of covid-19 is a new research question. physical and social isolation, home isolation, and quarantine policies applied during epidemic periods such as sars, mers, ebola have been associated with lifestyle changes (lippi, 2019). much of the research on the health impact of epidemics and isolation has focused on psychological issues such as stress-related symptoms and disorders and to a lesser extent social support and stress management. in contrast, the epidemic and its associated lifestyle issues during quarantine and isolation, including the impact of dietary changes, restricted physical activity, and increased indoor and screen time, are still not investigated. a limited number of studies have examined lifestyle changes during covid-19 and previous epidemic periods. however, there is no turkish survey that comprehensively deals with the lifestyle, the scope of which is expanding, today. the brief multidimensional lifestyle assessment scale, which we planned to validate in our study, is a scale developed by balanzá-martínez et al to multi-dimensionally evaluate the lifestyle changes that occurred during the covid-19 outbreak. it consists of 7 parts (diet and nutrition, substance addiction, physical activity, stress management, restorative sleep, social support and environmental exposure) and a total of 27 items. there are response options measured using a 4-point likert scale. high scores indicate a healthy lifestyle (balanzá-martínez, 2021). in this context, we think that adapting the short multidimensional lifestyle assessment scale / short multidimensional inventory lifestyle evaluation - confinement (smile-c) questionnaire into turkish will make a significant contribution to the literature.


Eligibility criteria:
inclusion criteria: female and male participants aged 18-65, volunteering to participate in research exclusion criteria: inability to use a computer, tablet or mobile phone, not answering all the questions in questionnaire

Keywords: covid-19, pandemic, lifestyle
azithromycin in the treatment of m. avium complex lung disease

Conditions: Mycobacterium Avium Complex Lung Disease

Summary: to determine the safety and efficacy of azithromycin in the treatment of lung infection with m.avium complex and m. abscessus lung disease.

to study the safety and efficacy of azithromycin in combination treatment for m. abscessus and mac lung disease

Eligibility criteria:
inclusion criteria: * meet american thoracic society criteria for nontuberculous lung disease: two or more afb smear positive, culture positive sputums or bronchoscopic samples and/or two or more afb smear negative respiratory samples with moderate to heavy growth (2+-4+); abnormal cxr consistent with m. avium lung disease; abnormal cxr consistent with m. avium lung disease; absence of other lung pathogens (except for the coexistence of m. abscessus). * age 18 and older * pretreatment isolate of m. avium complex available for mic determination exclusion criteria: * history of macrolide allergy * received macrolide therapy in last two months * children less than 18 years of age * if a menstruating female, not pregnant and on adequate birth control

Keywords: mac
melatonin supplementation for delirium prevention in acutely hospitalized elderly

Conditions: Delirium

Summary: 122 people over 70 who were admitted to hospital were enrolled to the study. half got .5 mg a night of melatonin, half got a placebo.


Eligibility criteria:
inclusion criteria: * age over 65 admitted through the emergency department to an internal medicine service in london, ontario, canada. exclusion criteria: * life expectancy less than 24 hours, * unable to communicate in english, * unable to take oral medications, * intracranial bleed or known seizure disorder, * markedly sub or supra-therapeutic inr while on warfarin, or * a known allergy to study tablet ingredients.
safety and efficacy of the surveil™ drug-coated balloon (avess fih)

Conditions: Hemodialysis Access Failure

Summary: the purpose of this study is to evaluate the safety and performance of the surveil dcb in subjects with obstructive lesions of arteriovenous fistulae for hemodialysis.

avess fih is a prospective, multi-center, single arm, first-in-man feasibility study evaluating up to 15 subjects

Eligibility criteria:
inclusion criteria: 1. subjects must be ≥18 years of age. 2. native av fistula has been created ≥60 days prior to the index procedure. 3. av fistula, located in the arm, has undergone one or more successful hemodialysis sessions. 4. target de novo or non-stented restenotic lesion consisting of a ≥50% stenosis by operator visual estimate. 5. fistula vessel diameter ≥5 mm and ≤7 mm by operator visual estimate. 6. target lesion or tandem lesion ≤120 mm in total length by operator visual estimate. 7. successful pre-dilatation of the target lesion. defined as crossing of the guide wire and pre-dilatation with a pta balloon resulting in: residual stenosis of ≤30% and dissection ≤ grade b 8. subject has provided written informed consent and is willing to comply with study follow-up requirements. 9. subject has a life expectancy of ≥1 year exclusion criteria: 1. subject has a synthetic av graft. 2. determined by operator to have a lesion that prevents complete inflation of an angioplasty balloon. 3. presence of pseudoaneurysm or aneurysm requiring treatment at the lesion site. 4. target lesion is located \<30 mm from any stent. 5. thrombosis of the access site 30 days prior to procedure. 6. surgical revision of the access site planned within 30 days of procedure. 7. blood coagulative disorder, sepsis, or current av access infection (white blood count ≥12,000). 8. known contraindication (including allergic reaction) or sensitivity to antiplatelet therapy, anticoagulation therapy or paclitaxel (mild to severe cases), that cannot be adequately managed with pre-and post-procedure medication. 9. subjects who are taking immunosuppressive therapy or are routinely taking ≥10mg of prednisone per day. 10. scheduled for kidney transplant or peritoneal dialysis within the next 6 months post procedure. 11. myocardial infarction 30 days prior to procedure. 12. stroke or tia 90 days prior to procedure. 13. women who are pregnant, breast-feeding or intend to become pregnant or men who intend to father children during the time of the study. 14. subject is participating in any other investigational study that has not completed primary endpoint(s) evaluation or that clinically interferes with the endpoint from this study.
trained immunity in thyroid carcinoma and colon carcinoma

Conditions: Thyroid Cancer, Nonmedullary; Colon Carcinoma

Summary: tumor-related inflammation is one of the hallmarks of cancers in general. innate immunity specifically is a common denominator which is involved in the pathogenesis of both thyroid carcinoma and colon carcinoma. to improve the patient's outcome and identify novel therapeutic targets, one needs a deeper understanding of the tumor-induced changes in the bone marrow myeloid progenitor cells. furthermore, treatment of these cells by nanoparticles or other agents that induce a program of 'trained immunity' may be a novel way to re-educate myeloid cells and their bone marrow progenitors in thyroid carcinoma patients. lastly, the investigators expect that this approach could be effective also in other cancers of which colon carcinoma is here proposed as an additional model. the investigators hypothesize that by exposing myeloid cells or their progenitors to various agents that induce trained immunity (e.g. high-density-lipoprotein-methylene diphosphonate nanoparticles, recombinant and synthetic cytokines), these immune cells will undergo functional reprogramming to induce a tumor-suppressive phenotype. in the future, this could be explored as a novel immunotherapy for tumors that are refractory to conventional treatment.


Eligibility criteria:
inclusion criteria: * at least 18 years old and mentally competent * newly diagnoses non-medullary thyroid carcinoma or colon carcinoma that is therapy naïve * planned to receive conventional treatment for the malignancy by surgery exclusion criteria: * mentally incompetent * pregnant or breastfeeding * known inflammation or infectious disease or an immunosuppressive status * using medication interfering with the immune system * reduced platelets counts or other conditions associated with an increased risk of bleeding * severe comorbidities: other active malignancy (except for basal cell carcinoma and other in situ carcinomas) * previous anti-cancer treatment, such as chemotherapy, radiotherapy or surgical removal or the primary tumor * serious psychiatric pathology * a self-reported alcohol consumption of \>21 units per week
effect of probiotic supplements on gastric cancer patients receiving neoadjuvant chemotherapy

Conditions: Gastric Cancer; Neoadjuvant Chemotherapy

Summary: background: surgery can significantly improve the prognosis of patients with gastric cancer. however, some patients are at a later stage at diagnosis and need to receive neoadjuvant chemotherapy (nact). previous studies have shown that nact may lead to more postoperative complications. probiotics have the potential to reduce postoperative complications and infections, but no large sample, multicentre, randomized clinical trials have been conducted in patients with gastric cancer receiving nact. the aim of this multicentre randomized controlled trial was to investigate the effect of probiotics on postoperative infections and other short-term outcomes in patients with gastric cancer receiving nact. methods/design: this study is a prospective, multicentre rct. this experiment will consist of two groups - an experimental group and a control group - randomly divided in a 1:1 ratio. the experimental group will receive perioperative probiotic supplement and that of the control group will receive blank control management. an estimated 318 patients will be enrolled. the main endpoint for comparison is postoperative infections between the two groups.the experimental group patients received probiotic capsules containing bifidobacterium longum, lactobacillus acidophilus, and enterococcus faecalis.


Eligibility criteria:
inclusion criteria: * 18-80 years old * male and female * clinical stage was t3/4n+ evaluated by ct/mr/eus at new diagnosis (before any anti-cancer treatment) , complete 2-4 cycles preoperative chemotherapy based on 5-fu (such as sox, flox, ect.) at 3-6 weeks before surgery * asa grade was ⅰ\~ⅲ * radical minimal-invasive gastrectomy via laparoscope or davinci is judged as possible * histologically confirmed gastric adenocarcinoma * ecog score is 0\~1 * patients who provide a written informed consent before entering study screening exclusion criteria: * need emergency surgery due to performation and/or obstruction * receive antibiotics and/or glucocorticoids within 14 days before surgery * exist bacterial infection and/or autoimmune disease and/or ibd currently * intolerance or allergic to probiotics * upper abdominal surgery history * use probiotics within 7 days before intervention, such as yogurt, ect. * participate in other clinical trials currently * severe mental illness * can not participate in this trial due to severe illness of other organs evaluated by researchers, such as severe cardiac insufficiency (lvef\ ⅱ, severe arrhythmia, congestive heart failure, myocardial infarction within 6 months), liver dysfunction (child-pugh c), renal dysfunction (need hemodialysis) * need simultaneous surgery * lactation or pregnancy * refuse to participate in this trial
efficacy of artificial intelligence-generated music therapy in reducing dental anxiety among adults undergoing impacted third molar extraction

Conditions: Tooth Extraction; Molar, Third

Summary: music therapy is widely used in dentistry as it helps patients remain distracted during procedures, particularly during implant placement or third molar extraction. this therapy refers to the evidence-based clinical use of music to achieve therapeutic goals, administered by a licensed practitioner. due to the high prevalence of complications associated with the eruption and development of wisdom teeth, there has been an increase in the rate of surgical extractions, which in turn elevates patients' dental anxiety. music therapy may aid in the management of anxiety and thereby contribute to a reduction in pain perception. it is a favorable technique due to its low cost and minimal associated risks. in this context, and considering the widespread use of music as a therapeutic tool alongside the emergence of novel technologies-particularly artificial intelligence (ai)-this study aims to evaluate the efficacy of ai-generated music therapy in reducing dental anxiety during impacted third molar extraction procedures.


Eligibility criteria:
inclusion criteria: * patients over 18 years of age who provided informed consent * patients without severe or uncontrolled systemic diseases * patients capable of completing the dental anxiety questionnaires exclusion criteria: * patients under 18 years of age * patients with severe or uncontrolled systemic diseases * patients using anxiolytic medications * patients unable to complete the dental anxiety questionnaires

Keywords: third molar extraction music therapy anxiety
efficacy of 24-hour intraocular pressure fluctuation recording with the sensimed triggerfish contact lens sensor

Conditions: Primary Open Angle Glaucoma; Healthy Subjects

Summary: the objectives of this study are to assess the safety and effectiveness of the sensimed triggerfish® (tf) device in continuous recording of relative fluctuation in intraocular pressure (iop). safety will be assessed by recording of aes during the 24 hours of continuous tf recording. tf efficacy will be evaluated by demonstrating tf ability to detect: 1. the known phenomenon of increase in iop when moving from waking state to going to bed, as reflected in pneumotonometer measurements 2. ocular pulse frequency relative to direct measurement of heart rate (hr). a screening visit and one 24-hour iop fluctuation recording session are planned for each patient. iop fluctuation recording sessions will be carried out in a sleep unit. an ophthalmological examination of the eyes will be done at screening and prior to and following the device recording.


Eligibility criteria:
inclusion criteria: * signed informed consent for the investigation * diagnosis of primary open angle glaucoma (poag), including normal tension glaucoma, or healthy subjects, including subjects with ocular hypertension for whom no evidence or suspicion of structural or functional glaucomatous damage exists * no anti-glaucomatous drug treatment or washed-out for 4 weeks * iop symmetry of +/- 3 mmhg between fellow eyes * age 18-80 years * not more than 4 diopters spherical equivalent on both eyes * not more than 2 diopters cylinder equivalent on both eyes exclusion criteria: * patients who have had ocular surgery within the last 3 months. * corneal or conjunctival abnormality hindering contact lens adaptation * wear of full frame metallic glasses during sensimed triggerfish® monitoring * severe dry eye * secondary forms of open angle glaucoma (oag) * allergy to corneal anesthetic * patients with contraindications for silicone contact lens wear * patients not able to understand the character and individual consequences of the investigation * simultaneous participation in other clinical research
supplementation of land-based stearidonic acid (sda)-rich oils in humans

Conditions: Hypercholesterolemia; Overweight

Summary: the objective of this study is to investigate the conversion of the precursors ala and sda into n-3 lc-pufa (epa, dpa and dha) in humans by oral supplementation of echium oil in comparison with sda soybean oil (positive control). in addition, the accumulation of n-3 lc-pufa is compared between subpopulations of different age, gender and physiological conditions (overweight, increased serum total cholesterol).

n-3 pufa are important for human health and nutrition. due to the increasing world population, overfishing of the seas and generally low amounts of n-3 pufa in major oil crops, there is a demand for new sources of n-3 pufa. one approach involves searching for potential vegetable sources of n-3 pufa; especially those rich in ala and sda. the conversion of ala to sda in humans depends on the rate-limiting ∆6-desaturation. plant-derived sda is therefore a promising precursor regarding endogenous synthesis of n-3 lc-pufa in humans. the enrichment of n-3 lc-pufa in human lipids during the supplementation of ala- and sda-rich echium oil will be compared with sda-rich soybean oil. eighty volunteers will be recruited and allocated into four study groups depending on age and bmi. three groups (each n=20) will receive daily ca. 20 g echium oil ( group 1 and 2: mean bmi \ 25). one group (n=20) will receive sda soybean oil ( dose with comparable amount of sda; bmi \< 25; mean age 25 and 55). the double-blind, randomized, parallel-designed study will start with a two-weeks run-in period, followed by an eight-weeks supplementation period. after the run-in period, one week and eight weeks of oil supplementation blood will be drawn and 24-h urine will be sampled.

Eligibility criteria:
inclusion criteria: * healthy subjects exclusion criteria: * cholesterol lowering drugs * chronic diseases * pregnancy, lactation * intake of nutritional supplements

Keywords: conversion of ala and sda metabolism of n-3 fatty acids
pivotal study in vap suspected or confirmed to be due to pseudomonas aeruginosa

Conditions: Pneumonia

Summary: this is a phase 3, multicenter, open-label, randomized active-controlled, parallel group to investigate the efficacy, safety and tolerability, and pharmacokinetics of intravenous murepavadin combined with of one anti-pseudononas antibiotic with that of two anti-pseudomonas antibiotics in the treatment of ventilator-associated bacterial pneumonia (vabp) in adult subjects.


Eligibility criteria:
key inclusion criteria: * subject has received mechanical ventilation for at least 48h at the time of the randomisation * acute physiology and chronic health evaluation (apache) of 8 to 30, inclusive, within 24h prior to randomization * presence of new or progressive infiltrate on chest x-ray * presence of clinical criteria consistent with vabp * high probability of vabp caused by pseudomonas aeriginosa key exclusion criteria: * known or suspected community-acquired bacterial pneumonia or viral, fungal, or parasitic pneumonia * known hypersensitivity or contra-indications to beta-lactam antibiotics, aminoglycosides, quinolones, colistin, or subjects with a clinically significant history of anaphylactic reaction * severe liver or renal impairment * women who are pregnant or nursing, or who are of chilbearing potential and unwilling to use acceptable method of birth control
gvax pancreas vaccine (with cy) in combination with nivolumab and sbrt for patients with borderline resectable pancreatic cancer

Conditions: Pancreatic Cancer

Summary: the purpose of this study is to evaluate the safety and clinical activity of folfirinox along with a whole cell vaccine with immune modulating doses of cyclophosphamide and nivolumab combined with stereotactic body radiation therapy (sbrt) in patients with pancreatic cancer.


Eligibility criteria:
inclusion criteria: * have histologically proven pancreatic cancer that is borderline resectable * no more than 1 month/cycle (28 days) of systemic therapy for pancreatic cancer * age \>18 years old. * eastern cooperative oncology group (ecog) performance status 0-1. * patients must have adequate organ and marrow function defined by study-specified laboratory tests. * woman of child bearing potential must have a negative pregnancy test. * must use an acceptable form of birth control while on study. * must be candidate for stereotactic body radiation therapy (sbrt) * ability to understand and the willingness to sign a written informed consent document. exclusion criteria: * had major surgery within the last 28 days * had an investigational drug or device within the past 28 days * prior treatment with immunotherapy agents (including, anti-pd-1, anti-pd-l1, anti-pd-l2, anti-ctla4, etc) * completed more than 1 month/cycle (28 days) of chemotherapy for pancreas cancer * patient on an immunosuppressive systemic treatment, such as steroids, in the past 2 years. * other cancer diagnosis requiring treatment within two years * history of allergic reactions related to the drugs (nivolumab, cyclophosphamide, gm-hetastarch, corn, dimethyl sulfoxide, fetal bovine serum, trypsin (porcine origin), yeast or any other component of the gvax vaccine) in this study. * patients receiving growth factors within the last 14 days. * currently have or have history of certain study-specified heart, liver, kidney, lung, neurological, psychological, immune or other medical conditions. * pregnant or breastfeeding. * have known history of infection with hiv, hepatitis b, or hepatitis c. * unwilling or unable to follow the study schedule for any reason. * presence of tissue or organ allograft, regardless of need for immunosuppression (including corneal allograft) * squamous pancreatic cancer or adenosquamous pancreatic cancer with malignant squamous cells \>30%

Keywords: neoadjuvant therapy immunotherapy cytoxan cyclophosphamide pancreatic vaccine sbrt gvax nivolumab borderline resectable radioimmunotherapy vaccine antibody anti-pd-1
the effectiveness of augmented reality facilitated education in promoting care management of malignant fungating wounds among oncology nurses

Conditions: Nursing Education

Summary: malignant fungating wounds (mfws) affect 5-14% of patients with advanced cancer, making them a common complication in this population. characterized by symptoms such as foul odor, heavy exudate, bleeding, moderate to severe pain, and infection, mfws cause significant physical discomfort and pose life-threatening risks while also leading to profound psychosocial issues, including shame and social isolation. these factors severely impact patients' quality of life, with half of those diagnosed surviving only six months on average. however, clinical nursing staff often lack adequate knowledge and skills in managing mfws, with an average accuracy rate of just 56.5%. notable deficiencies exist in areas such as wound disinfection, odor control, and wound assessment, directly affecting the quality of patient care and highlighting an urgent need for specialized mfw training. traditional mfw education often lacks real-life clinical scenarios and hands-on practice, resulting in a gap between learning and application and leaving learners ill-prepared for the complexities of clinical settings. in contrast, augmented reality (ar) technology presents new possibilities for nursing education. ar can create highly simulated clinical environments where learners can safely practice complex clinical skills, enhancing clinical decision-making abilities. the implementation of ar-based training programs provides nursing staff with a more realistic and effective learning experience, allowing them to better address the challenges posed by mfws and ultimately contributing to improvements in patient care and quality of life.


Eligibility criteria:
inclusion criteria: * full-time nursing staff working in oncology wards at a teaching hospital in northern taiwan * individuals willing to participate in the study and who have signed the informed consent form exclusion criteria: * nursing staff not assigned to oncology-related wards * individuals expected to be unable to complete full participation in the study