Kornimate/medical-research-clean huggingface dataset:
high power vs standard power rf ablation of atrial fibrillation in conscious patients

Conditions: Atrial Fibrillation

Summary: high rf energy ablation of atrial fibrillation is fast, safe, less painful and effective procedure.

atrial fibrillation (af) ablation is the most commonly performed radiofrequency (rf) ablation and is usually associated with a long procedural time and sensation of pain in conscious patients. prolonged radiation exposure during the procedure puts the patient and the operator at risk of malignancy and genetic abnormalities. complications such as asymptomatic cerebral lesions, tamponade, perforation, and also arrhythmia recurrence were associated with longer ablation time. high-power, shorter-duration radiofrequency ablation (hpsdrfa) appears to be a novel concept for atrial fibrillation (af) but there are scarce data in conscious patients. the lesion side index (lsi) value has been associated with durability of pulmonary vein isolation (pvi) lesions. we hypothesised that hpsdrfa applications based on the lesion side index (lsi; its has been associated with durability of pulmonary vein isolation (pvi) lesions) which were not inferior to standard approach regarding safety and effectiveness with shorten procedure time and being less painful for a patient.

Eligibility criteria:
inclusion criteria: * symptomatic patients with non-valvular af, * aged:18-85, first procedure in left atrium, * exclusion of thrombus in left atrium and left atrium appendage, * left ventricle ejection fraction \>55% exclusion criteria: * age below 18 or above 85 years, * left ventricle ejection fraction\<55%, * previous procedure in left atrium, * valvular af

Keywords: atrial fibrillation ablation high power radiofrequency ablation
evaluation of diet and exercise in prostate cancer patients

Conditions: Prostate Cancer

Summary: canadian real life evaluation of the effect of diet and exercise in prostate cancer patients managed with lupron.

this is a study utilizing a prospective cohort design. patients with prostrate cancer (pca) who are prescribed lupron will be entered into the study cohort and will be followed for a maximum of 18 months with recommended assessments at 3, 6, 12 and 18 months after day 1. treatment of the patients and follow up will be according to the physicians' judgment, regional regulations and the product monograph.

Eligibility criteria:
inclusion criteria: i. adult ≥ 18 years old ii. has provided written informed consent allowing the use of their data for the study and providing permission for contact by the study personnel. iii. diagnosed with pca. iv. prescribed lupron as part of his treatment by his treating physician. exclusion criteria: i. patient cannot or will not sign informed consent. ii. presence of other condition that, in the opinion of the treating physician, prohibits the patient from participating in the study or obscures the assessment of the treatment of pca. iii. more than 6 months of therapy if currently on continuous luteinizing hormone-releasing hormone (lhrh) treatment. iv. if at study enrollment the intent is to only prescribe 1 dose of lupron (leuprolide acetate)

Keywords: prostate cancer
open label safety study of a birch pollen allergen extract

Conditions: Rhinoconjunctivitis

Summary: this trial is performed to assess safety of a sublingual birch pollen extract.


Eligibility criteria:
inclusion criteria: * allergic rhinoconjunctivitis attributable to birch pollen * positive spt * positive east exclusion criteria: * serious chronic diseases * other perennial allergies * partly controlled asthma

Keywords: type i - allergy, rhinoconjunctivitis
living donor liver transplant for unresectable colorectal liver metastases

Conditions: Colorectal Cancer Metastatic

Summary: the goal of this study is to create a data registry to capture clinical, pathologic, and molecular data/outcomes for patients with metastatic colorectal cancer who undergo live donor liver transplantation.

the goal of this study is to create a data registry to capture clinical, pathologic, and molecular data/outcomes for patients with metastatic colorectal cancer who undergo live donor liver transplantation. our primary outcome of interest was the os and recurrence-free survival (rfs) of patients who underwent ldlt at our center.

Eligibility criteria:
inclusion criteria: * age ≥ 18 * non-amenable to curative hepatic resection as defined by flr \<30% * histologically confirmed adenocarcinoma of the colon or rectum * candidate for ldlt for colorectal liver metastasis per the university of rochester liver transplant program exclusion criteria: * not a candidate of the ldlt liver transplant protocol for treatment of colorectal liver metastasis. * unwilling to consent

Keywords: liver transplantation living donor unresectable colorectal liver metastases
comparative effects of getting it right addressing shoulder pain and rotator cuff strengthening exercise military sports

Conditions: Sports Physical Therapy

Summary: this research will use a randomized clinical trial (rct) method to get military athletes with rotator cuff tendinopathy. people will be chosen at random to either get the grasp method or normal exercises for making the shoulder muscles stronger. the main things the investigator will look at are how bad the pain is how well the shoulder works and if they can go back to work or sports. tests will be done at the start, right after a treatment, and later times to measure the short-term and long-term advantages of the treatments. this study's careful way of doing things aims to provide strong information for military sports medicine. it helps doctors in treating shoulder problems like rotator cuff tendinopathy.

the rationale for conducting this study lies in the critical need to address rotator cuff tendinopathy, a prevalent and debilitating issue among military athletes. the unique demands placed on military personnel, involving repetitive overhead tasks and rigorous training, contribute significantly to the higher incidence of rotator cuff problems. the impact of this condition on performance, readiness, and overall well-being in the military cannot be overstated. in the end, the plan for this study wants to fix a gap in what we know right now about dealing with muscle problems in military sports players' shoulders. this study looks at the grasp trial methods and compares them with standard rotator cuff exercises. it aims to improve treatments and help military staff be healthier and work better.

Eligibility criteria:
inclusion criteria: * people in the military who are between 18 and 50 years old. * active participation in sports activities for the military. * diagnosing rotator cuff tendon pain in medical practice. * basic shoulder movement within a certain range of motion. exclusion criteria: * history of shoulder surgery. * systemic inflammatory diseases. * disorders of the brain or mind that affect physical actions. * not being able to stick to the plan for later.

Keywords: rotator cuff tendinopathy grasp trails military sports shoulder pain
pd-1 antibody and lenvatinib plus tace on downstaging bclc b/c hcc

Conditions: Hepatocellular Carcinoma

Summary: the purpose of this study is to assess the difference of safety and efficacy about pd-1 antibody and lenvatinib plus transcatheter arterial chemoembolization (tace) on downstaging hepatocellular carcinoma with bclc b/c.


Eligibility criteria:
inclusion criteria: 1. age ≥18 years old and ≤75 years old; 2. clinically diagnosed as hepatocellular carcinoma, stage b/c of bclc; 3. no history of severe arrhythmia or heart failure; 4. no history of severe ventilation dysfunction or severe pulmonary infection; 5. no acute or chronic renal failure, the creatinine clearance rate was \>40 ml/min; 6. liver function child a; 7. blood routine: absolute neutrophils count ≥1.5×10\^9/l, hb≥8.5g/l, plt≥75×10\^9/l; 8. coagulation function: inr≤2.3; 9. ecog score \<2; 10. no local or systemic treatment, such as tace, rfa, targeted drugs, traditional chinese medicine, etc., before enrollment; 11. expected survival ≥12 weeks; 12. at least one lesion can be measured and evaluated by ct/mri according to recist 1.1 criteria; 13. understand and sign the informed consent. exclusion criteria: 1. pregnant or lactating women; 2. patients with other malignant tumors; 3. patients with complicated mental illness; 4. patients who have participated in other clinical trials in the last three months; 5. known or suspected allergy to any drug related to the study; 6. patients with positive immunodeficiency virus (hiv) or acquired immunodeficiency syndrome (aids) 7. patients treated with other targeted drugs, pd-l1 antibody and other immunotherapy or folfox systemic chemotherapy after inclusion; 8. patients with ≥1 + proteinuria indicated by urine routine will receive 24-hour urine protein detection, and patients with ≥1g 24-hour urine protein will not be included in the group. 9. active autoimmune diseases that require systemic treatment (use of disease-alleviating agents, such as corticosteroids or immunosuppressants) 10. patients with uncontrolled hepatitis b/c infection 11. other conditions that the researcher considers not suitable for inclusion in this study

Keywords: lenvatinib pd-1 tace downstaging
non-pharmacological treatments for non-malignant and malignant pain

Conditions: Comparison of Treatment for Chronic Non-malignant and Malignant Pain

Summary: chronic pain concerns one in four adults in belgium. because of the psychological and social repercussions, a biopsychosocial approach is necessary in order to improve the quality of life of people suffering from chronic pain. non-pharmacological techniques such as hypnosis, self-care learning and music-therapy are gaining more and more interest in the scientific field. indeed, several studies have shown a reduction in psychological distress and an improvement in global quality of life after having learned self-hypnosis/self-care. furthermore, other studies focusing on music as a treatment for chronic pain highlight an analgesic effect of music over pain and a reduction of common comorbidities. nevertheless, only few studies aim at comparing these techniques to each other. the aim of our study would be to compare a 7 months learning program of self-hypnosis/self-care, music-therapy/self-care, motivation to learn self-hypnosis/self-care in order to highlight the most efficient treatment for chronic pain. furthermore, we will include another type of chronic pain i.e. cancer pain to understand if self-hypnosis/self-care's impact is different in the other type of chronic pain.


Eligibility criteria:
inclusion criteria: * major * fluency in french * chronic pain diagnosis (malignant and non-malignant) exclusion criteria: * neurologic disorder * psychiatric disorder * drug addiction * alcoholism

Keywords: chronic pain cancer self-hypnosis self-care music-therapy motivation
study of two intrathecal doses of autologous mesenchymal stem cells for amyotrophic lateral sclerosis

Conditions: AMYOTROPHIC LATERAL SCLEROSIS

Summary: the study aims to evaluate primarily safety of two injections of autologous mesenchymal stem cells in amyotrophic lateral sclerosis patients. secondary outcomes of efficacy will also be evaluated

the study is an open-label, unmasked, uncontrolled phase i and ii trial to evaluate safety and efficacy of two injections of autologous mesenchymal stem cells (msc) in amyotrophic lateral sclerosis (als) patients. patients will be recruited trough a web-based registration system, open for all als brazilian patients. the patients will be enrolled after in-person screening at the university of sao paulo medical school clinics hospital and inclusion criteria fulfilled. there will be 9 national calls for registration, two months apart each. the enrolled patients will be followed for 3 months before bone marrow aspiration (bma). patients will receive 2 intrathecal msc injections, 1 and 2 months after bma. the patients will be followed for 6 months after the interventions.

Eligibility criteria:
inclusion criteria: 1. age between 18 and 70 2. possible, probable or definite als following el escorial revised criteria (brooks, 2000) 3. alsfrs-r ≥30 at enrollment 4. forced vital capacity ≥65% of the height and weight standard 5. no-pregnancy agreement 6. regional accessibility to the study site 7. capability to give away agreed consensus 8. patients will be followed at academic institutions at their hometown exclusion criteria: 1. previous cellular therapy 2. incapacity to lay still during bone marrow aspirate or intrathecal msc injections 3. personal history of auto-immune, myeloproliferative or myelodysplastic diseases, leukemia, lymphoma, whole-body irradiation, hip fracture, severe scoliosis or incapacity to undergo any of the study's proposed procedures 4. any other disease that may interfere with the study 5. any other neurological diseases 6. aspartate or alanine aminotransferases elevated \>3x normality upper limit 7. serum creatinine \>2x normality upper limit 8. hepatitis b and c, hiv, htlv i and ii and syphilis 9. immunosuppressant drug use within 6 weeks from the study's screening 10. pregnancy or breast-feeding 11. acquired or inherited immunodeficiency 12. participation in other clinical trials 13. non-invasive ventilation, tracheostomy or diaphragm pacing 14. substance abuse within one year and other unstable mental health diseases according to researcher's judgement 15. gastrostomy or any alternative feeding means 16. inappropriate in-vitro msc expansion

Keywords: als mesenchymal stem cells intrathecal
uterine doppler as stillbirthpredictor

Conditions: Intrauterine Fetal Death

Summary: the goal of this observational study is to define the predictive value of intrauterine fetal death for different longitudinal patterns of uterine artery doppler indices (uta-pi, uta-ri and notch) from the second and third trimester of pregnancy in patients admitted with a diagnosis of intrauterine foetal death in the period january 2010-april 2020.

no changes in the obstetrical conduct of patients with mefs are expected, since the data will be analysed retrospectively in patients in whom the event of intrauterine foetal death has already occurred. patients will be treated according to normal clinical protocols. the following information will be recorded for each patient * age * body mass index (bmi) * ethnicity * parity * method of pregnancy onset (spontaneous vs. medically assisted procreation) * maternal pathologies (if any) * any foetal pathologies * ultrasound parameters in the second and third trimester of pregnancy * estimation of fetal weight * umbilical artery doppler (ua-pi) * uterine artery doppler (uta-pi, uta-ri and notch) * gestational age of fetal endouterine death * type of delivery * newborn and placental weight * histopathological findings of newborn and annexes (placenta and umbilical cord)

Eligibility criteria:
inclusion criteria: * fetal endouterine death in single pregnancies with gestation period ≥ 24 weeks * obtaining informed consent form exclusion criteria: * multiple pregnancies

Keywords: uterine doppler
postmarket clinical follow-up study on arcadius xp l® interbody fusion device

Conditions: Chronic Low-back Pain; Degenerative Disc Disease; Spondylolysis Lumbar; Postdiscectomy Syndrome; Posttraumatic Instability

Summary: the purpose of this study is to collect clinical and radiological mid-term (min. 1 year) data on the arcadiusxp l® lumbar stand-alone cage in a post-market clinical follow-up study (pmcf) limited to 60 patients.


Eligibility criteria:
inclusion criteria: * all patients who received a arcadius xp l® interbody fusion device between 2016 until approx. january 2021 (minimum follow-up is one year) in the study center * all indications as given by the instructions for use: degenerative disc disease (ddd), instability, spondylolisthesis up to grade 1, post-discectomy syndrome, post-traumatic instability * written informed consent for the documentation of clinical and radiological results exclusion criteria: * patient is not willing or able to participate at the follow-up examination * patients living outside a radius of 100 km around the study center * all contraindications as given by the instructions for use:

Keywords: stand-alone cage lumbar spine interbody fusion device
an open label safety and tolerability study of ain457 in patients with moderate to severe crohn's disease

Conditions: Crohn's Disease; Inflammatory Bowel Disease

Summary: this study will assess the safety and tolerability of ain457 in patients with moderate to severe crohn's disease who already participated and completed the core trial cain457a2202.


Eligibility criteria:
inclusion criteria: * patients who participate and complete the core cain457a2202 study up to and including visit 11 (end of study), may enter the extension study upon signing informed consent. exclusion criteria: * patients for whom continued treatment with ain457 is not considered appropriate by the treating physician. * patients who were non-compliant or who demonstrated a major protocol violation in the core cain457a2202 study * patients who discontinued from the core cain457a2202 study before visit 8 (day 43). other protocol-defined inclusion/exclusion criteria may apply

Keywords: crohn's disease crohns bowel disease digestive disorders auto immune diarrhea inflammatory bowel disease (ibd) gastrointestinal diseases digestive system diseases antibody il 17 anti il-17 monoclonal antibody crohn's disease (chron's, cd)
mindfulness-based stress reduction, health education and exercise

Conditions: Age-related Cognitive Decline

Summary: the purpose of this research is to examine the effects of four interventions on age-related cognitive decline in healthy older adults. the investigators will examine the effects of mindfulness based stress reduction (mbsr) psychotherapy, multi-component intensity-based aerobic exercise, and their combination, compared to a discussion group.

mbsr teaches mindfulness, or the focusing of attention and awareness, through various meditation techniques. mindfulness meditation practices appear to produce neurocircuitry changes that are the reverse of those seen in age-related cognitive decline. it is widely available, acceptable to older people, and carries minimal risk of side effects or adverse events. exercise - specifically, intense, multi-component exercise - also appears to affect brain structure and function and improve cognitive performance. the investigators will randomize 580 non-demented healthy adults aged 65 to 84 to one of four conditions: mbsr alone, exercise alone, mbsr + exercise, or a health education discussion group control condition. the study will consist of a 6-month acute intervention phase with weekly visits followed by a 12-month maintenance phase with weekly or monthly visits and other prompts to maintain intervention behaviors. assessments include cognitive tests, biomarkers, neuroimaging assessments, functional assessments to examine real-world benefits of the interventions, and other behavioral assessments to characterize participants and pave the way for further exploratory analyses.

Eligibility criteria:
inclusion criteria: * community-living men and women age 65 to 84. * self-reported cognitive complaints that are a normal part of aging. * no current meditation practice nor prior training in it. * sedentary. exclusion criteria: * known diagnosis of dementia, mild cognitive impairment, other clinical neurodegenerative illness (e.g., parkinson's disease, cerebrovascular disease), psychotic disorder, or any unstable psychiatric condition. * medical conditions that suggest shortened lifespan, such as metastatic cancer; or would prohibit safe participation in the interventions, including cardiovascular disease or musculoskeletal conditions; or would interfere with the assessments, such as taking medications for diabetes or ferromagnetic metal/bridgework that would interfere with mri signal. * iq \<70 as estimated by the wechsler test of adult reading * sensory impairment (language, hearing, or visual) that would prevent participation. * alcohol abuse within 6 months. * current illicit drug use. * concurrent cognitive training, such as brain-training software, or other interventions expected to affect neuroplasticity. * medications that interfere with measurements, including cancer chemotherapy, glucocorticoids, and interferon. * inability to cooperate with protocol.

Keywords: exercise mindfulness education elderly
safety and efficacy of k-134 for the treatment of intermittent claudication

Conditions: Intermittent Claudication

Summary: the purpose of this study is to evaluate the safety and efficacy of k-134 for the treatment of intermittent claudication.


Eligibility criteria:
inclusion criteria: - stable claudication symptoms exclusion criteria: * lower extremity amputation * signs or symptoms of critical leg ischemia (cli) * uncontrolled hypertension * tachycardia * poorly controlled diabetes * hypercholesterolemia

Keywords: intermittent claudication peripheral arterial disease
cpap versus bilevel pressure support ventilation in cardiogenic pulmonary edema

Conditions: Severe Acute Cardiogenic Pulmonary Edema

Summary: to evaluate whether bilevel positive airway pressure more rapidly improves ventilation than continuous positive airway pressure (cpap) in patients with acute pulmonary edema. cpap is delivered via a simple device connected to oxygen.


Eligibility criteria:
inclusion criteria: * age \> 16 yrs, acute onset of severe respiratory distress, bilateral rales and typical findings of congestion on chest radiograph * breathing frequency of \> 30/min, spo2 \>90%, use of accessory respiratory muscles

Keywords: pulmonary edema, respiratory failure, pressure support ventilation, continuous positive pressure