Kornimate/medical-research-clean huggingface dataset:
prone breast radiotherapy treatment planning observational study

Conditions: Breast Cancer Female

Summary: the study purpose is to evaluate whether or not clinical characteristics of women with breast cancer can predict which position for radiation treatment, prone or supine, will be associated with a dosimetry gain. dosimetry gain in this study means the lowest radiation dose to non-target organs (heart, lungs, contralateral breast), while giving the prescribed dose to tumor bed and ipsilateral breast.

retrospectively identify women who received curative radiation treatment after breast conserving cancer surgery, in whom simulation in prone and in supine position was performed. compare the treatment plans for doses to targets and to non-target organs, according to clinical parameters of body mass index, size of breast, location of tumor and side. furthermore, evaluate whether a single ct slide is enough or not to predict a dosimetry advantage.

Eligibility criteria:
inclusion criteria: * breast conserving surgery * adjuvant radiation treatment * simulation done prone and supine exclusion criteria: * simulation in only one position

Keywords: breast cancer breast conserving surgery. radiotherapy. treatment planning. prone.
randomized study of hypofractionated and conventional fractionation radiotherapy after breast conservative surgery

Conditions: Breast Cancer

Summary: early-stage breast cancer patients treated with breast conservative surgery are enrolled in this study if they meet defined criteria. patients are randomized into two groups: conventional fractionation radiotherapy and hypofractionated radiotherapy.the hypothesis is that conventional fractionation radiotherapy and hypofractionated radiotherapy have similar efficacy and toxicity.


Eligibility criteria:
inclusion criteria: 1. kps\>=60 2. histology confirmed invasive breast cancer 3. received breast conservative surgery(wide local excision and axilla dissection, or axillary sentinel node biopsy if sentinel node is negative) 4. surgical margins negative 5. primary tumor ≤5cm in the largest diameter 6. no internal mammary node or supraclavicular node metastases or distant metastasis 7. can tolerate chemotherapy,hormone therapy (if needed) and radiotherapy 8. for patients not need chemotherapy，enrollment date is required no more than 8 weeks from surgery date 9. for patients with chemotherapy first,enrollment date is required no more than 8 weeks from the last date of chemotherapy 10. patients signed written inform consent form exclusion criteria: 1. ductal carcinoma in situ 2. prior neoadjuvant chemotherapy 3. prior breast cancer history 4. bilateral breast cancer 5. pregnant or during lactation 6. prior or concomitant malignant tumor excluded skin cancer(not malignant melanoma) and cervix carcinoma in situ 7. active collagen vascular disease 8. prior neoadjuvant hormone therapy 9. immediate ipsilateral breast reconstruction

Keywords: breast cancer patients breast conservation surgery hypofractionated radiotherapy
ebus-ttfb vs ebus-tbna for diagnosing inadequate lymph node specimens based on mose

Conditions: Lymphadenopathy

Summary: the study aims to compare the efficacy and safety of endobronchial ultrasound-guided transtunnel forceps biopsy to transbronchial needle aspiration in diagnosing inadequate lymph node specimens based on macroscopic on-site evaluation.

mediastinal and hilar lymphadenopathy are common clinical conditions. endobronchial ultrasound-guided transbronchial needle aspiration (ebus-tbna) is the standard method recommended by guidelines for obtaining tissue from these patients. endobronchial ultrasound-guided transbronchial forceps biopsy (ebus-tbfb) can overcome the limitations of inadequate tissue acquisition with ebus-tbna, and its efficacy and safety have been proved. however, ebus-tbfb often requires the assistance of the electrocautery for mediastinal window creation, which increases technical difficulty and requires electrosurgical equipment, making it unsuitable for application in grassroots hospitals. this study aims to use the endobronchial ultrasound-guided transtunnel forceps biopsy (ebus-ttfb) method. a single-use bronchoscopic puncture dilation catheter will be employed to establish a tunnel between the airway and the lymph node, with both puncture and dilation completed in the same procedure. currently, there is a lack of prospective randomized controlled trials to verify the efficacy and safety of ebus-ttfb. this study is designed as a prospective, multicenter, randomized controlled trial. a total of 162 patients will be randomly allocated in a 1:1 ratio to the ebus-tbna group or the ebus-ttfb group. the primary endpoint is thediagnostic yield. the secondary endpoints include specimen adequacy, procedure duration, tunnel creation success rate, and safety.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years; 2. chest imaging shows mediastinal or hilar lymphadenopathy (short axis ≥10 mm), requiring ebus-tbna for definitive diagnosis; 3. ebus-tbna can be performed on these lymph nodes, and the specimens obtained from conventional ebus-tbna with three needle passes are inadequate (macroscopic visible core \< 30 mm); 4. willing to participate in this clinical study and sign the informed consent form. exclusion criteria: 1. enlarged lymph nodes are identified as cystic or abscesses; 2. severe coagulopathy, insufficient anticoagulants/antiplatelets withdraw time or bleeding diathesis (platelets\ 1.3) that do not meet bronchoscopy requirements; 3. other contraindications to bronchoscopy or transbronchial biopsy, such as severe cardiopulmonary insufficiency, intolerance to anesthesia, or endoscopic procedures; 4. patients who have participated in another clinical trial within the past three months; 5. vulnerable groups, such as pregnant women 6. any other condition that the investigator considers inappropriate for participation in this study.
intervening in food insecurity to reduce and mitigate (inform) childhood obesity

Conditions: Pediatric Obesity; Nutrition Disorders; Overnutrition, Child; Obesity

Summary: the goals of this study are to 1) pilot the feasibility of a novel meal kit delivery intervention in families and children with food insecurity and obesity and 2) evaluate the implementation of the pilot intervention.

childhood obesity prevalence is rising in the u.s. and is known to track into adulthood, increasing the risks of chronic diseases such as type 2 diabetes. households of children with obesity also face unmet social needs, such as food insecurity. food insecurity is associated with poorer dietary quality and higher prevalence of obesity and diabetes in adults; however, data are inconsistent and less known regarding longitudinal health effects in children. because food insecurity and childhood obesity tend to co-occur in black, hispanic, and lower-income households, there is an urgent need to examine and intervene in the social determinants associated with rising childhood obesity prevalence.

Eligibility criteria:
child inclusion criteria: * children \>=6 years and \ =95th percentile * children who screen positive on the 2-item hunger vital sign™ * children living in a household of \<=5 people * children living with an english and/or spanish-speaking caregiver * children living within the eatwell delivery map boundaries in the greater boston area child exclusion criteria: * history of food allergies or intolerance to dairy, gluten, soy, or any potential component of the meal kit * history of malabsorptive intestinal disease (e.g., crohn's disease, celiac disease) * history of type 1 or 2 diabetes * history of solid tumor or bone marrow transplant * enteral tube dependence the child's primary caregiver will be eligible for enrollment.

Keywords: food insecurity nutrition security
high intensity resistance and aerobic training among women with pcos

Conditions: Polycystic Ovary Syndrome

Summary: polycystic ovarian syndrome (pcos) is the most common endocrine female disorder, affecting 4-18% women of reproductive age. the prevalence of pcos in south asian women, especially in pakistani women, is much higher (52%) as compared to white population (20 - 25% in uk). on the basis of cultural, environment, diet and lifestyle practices these women are more prone to development of such disorder. so such public health issue needs to be addressed by strong evidence conducted by a clinical trial. the current study is planned to compare effects of two different exercise protocols of high intensity on anthropometric measures, hormonal profile and quality of life.

pcos is a prevalent condition that is affecting adolescent girls now and has serious impacts on menstrual health and quality of life making them prone to early risk development for chronic metabolic diseases. the comparison between high intensity resistance and aerobic training would give results that which one is more effective in gaining benefits and better effects on overall health both physically(menstrual) as well as mentally that would eventually tell us about the quality of life of such patients. after the initial screening process, the participants fulfilling the roterdam criteria, willing to participate in the exercise trial will be recruited and then randomized to the allocated groups of either high intensity resistance or high intensity aerobics. at baseline, their anthropometrics measurements, lh/fsh ratios and fasting plasma glucose test will be done. patient will be called thrice a week for 3 months for training. it is hypothesized that high intensity resistance or high intensity aerobics will improve anthropometric measures along with hormonal profile and quality of life.

Eligibility criteria:
inclusion criteria: * women diagnosed with pcos according to rotterdam criteria * age limit: 18-30 * women who are not part of planned physical activity for the last six months. * bmi\<=30 exclusion criteria: * women with pcos who are already on birth control or hormone therapy. * women with pcos who are already are taking some medication for psychological issues * women who are already taking cholesterol control medications. * women who are a part of any physical activity already
preliminary study on the clinical effect of recombinant human brain natriuretic peptide on sepsis complicated with heart failure

Conditions: Sepsis

Summary: the investigators intend to conduct clinical studies to determine the efficacy of rhbnp in the treatment of septic related dysfunction and kidney dysfunction

sepsis is one of the common critical diseases in icu with high mortality. septic shock patients are often accompanied by multiple organ dysfunction (mods), of which more than 50% of patients with varying degrees of myocardial injury.the investigators hope to find a drug with a protective effect on cardiac function and kidney function, so as to treat sepsis more effectively in the treatment of sepsis. recombinant human brain natriuretic peptide (rhbnp) was approved by fda in 2001 for the treatment of acute decompensated heart failure.these effects play a role in the protection of cardiac and kidney function, and have achieved good results in patients with cardiac insufficiency and aki caused by cardiac surgery. the investigators are going to carry out related research from the following aspects: 1. to determine the effect of rhbnp on hemodynamics in sepsis based on picco hemodynamic monitoring; 2. to collect and sort out the relevant data to determine the effects of rhbnp on cardiac function and kidney function, including cardiac ultrasound, kidney blood flow index and related laboratory tests. 3. to determine the effect of rhbnp on the final prognosis of patients, including icu mortality and hospital mortality, icu time, hospital stay, ventilator use time, kidney replacement therapy time, vasoactive drug dosage and time.

Eligibility criteria:
inclusion criteria: * sepsis complicated with heart failure（diagnosed by sepsis 3.0） * heart failure: bnp rises by 600 pg/ml * age\>=18 years old exclusion criteria: * hemodynamically unstable * pregnant * disagree with comprehensive and active life support treatment * coronary heart disease, myocardial infarction, and cardiac insufficiency * chronic renal insufficiency

Keywords: sepsis heart failure aki
physical training per se

Conditions: Insulin Sensitivity

Summary: the investigators aimed to evaluate the health benefits of physical training per se, weight loss per se and exercise-induced weight loss in young, overweight men. the investigators hypothesized that physical training would have independent effects on various health parameters (insulin sensitivity, fasting glucose and insulin, total and abdominal fat mass, waist circumference, blood pressure and key muscle proteins), and that a concomitant weight loss from physical activity would increase the effect.

at baseline, during the intervention and in the week following the intervention participants underwent a panel of tests: * cardio respiratory fitness * blood pressure * anthropometric measures at baseline and after the intervention a hyperinsulinemic, euglycemic clamp were performed to asses insulin sensitivity. tissue and blood samples were also collected for further analysis: * total-protein analysis of selected proteins * fasting plasma glucose, insulin and free fatty acids

Eligibility criteria:
inclusion criteria: * overweight (body mass index 25-30 kg/m2) * weight stable (±2 kg during the past 6 months) * body fat% \>25%, * maximal oxygen uptake \<45 ml/min/kg * sedentary and healthy according to interview * fasting glucose \<6.1 mmol/l * blood pressure \<140/90 mmhg * no first degree relatives with type-2-diabetes exclusion criteria: * resistance training * inability to meet intervention criteria
switching hiv-1 infected subjects from a highly active anti-retroviral treatment (haart) regimen dosed twice daily or more frequently to a once-daily regimen

Conditions: HIV Infections

Summary: the purpose of this study is to demonstrate that virologically controlled hiv-infected individuals can successfully switch from a standard-of-care regimen dosed twice-daily or more frequently to a simpler once-daily (qd) regimen while maintaining virologic control, as evaluated by the proportion of subjects who continue to have plasma hiv-1 levels \<50 copies/ml after switching to a qd regimen.


Eligibility criteria:
inclusion criteria: * documented hiv infection * 18 years of age or older and weigh at least 40 kg * two plasma hiv rna levels below the limit of quantification (one at least 90 days prior to the screening visit and one within 30 days of the patients baseline visit) * currently receiving a standard-of-care haart regimen with at least one agent being dosed twice-daily or more frequently exclusion criteria: * pregnancy, breastfeeding or plans to become pregnant during the study period * any prior documented virologic failure to one or more haart regimens * active aids-defining opportunistic infection or disease * proven or suspected acute hepatitis within 30 days prior to study entry

Keywords: hiv-aids
treatment of portal vein tumor thrombus after hepatocellular carcinoma resection

Conditions: Hepatocellular Carcinoma

Summary: hepatectomy is still the treatment of choice for hepatocellular carcinoma. part of the patients may present portal vein tumor thrombus (pvtt) after resection. pvtt might lead to upper gastrointestinal bleeding and worsening of hypersplenism which will endanger the life of the patients. pvtt also plays the centre role of recurrence and metastasis of hcc. there is no standard treatment for pvtt yet. we aim to compare the effects of tace and tace plus laser ablation for treating patients with pvtt.

hepatectomy is still the treatment of choice for hepatocellular carcinoma, but the prognosis is not agreeable. part of the patients may present portal vein tumor thrombus (pvtt) after resection. pvtt might further increase the pressure of portal vein and lead to upper gastrointestinal bleeding and worsening of hypersplenism which will endanger the life of the patients. pvtt also plays the centre role of recurrence and metastasis of hcc. there is no standard treatment available now for pvtt yet. tace is mostly often used to treat the pvtt. we aim to compare the effects of tace and tace plus laser ablation for treating patients with pvtt.

Eligibility criteria:
inclusion criteria: 1. pvtt after liver resection was diagnosed with at least two types of imaging findings, such as ct, mri or color doplor findings. 2. the functions of the kidney, heart and lung and the routine test of the blood are in good condition. 3. the liver function is of grade a or b in child-pugh classification. 4. the patient is eligible of the trial and will show consent to the test. exclusion criteria: 1. any of the parameters. wbc less than 2000/ml, hb less than 90g/l or plt less than 50000/ml. 2. disfunction of the heart, lung, kidney, or brain. 3. any other disease might affect the trial . 4. the patients would not sign the consent to the trial.

Keywords: hepatocellular carcinoma portal vein tumor thrombus laser ablation
body composition optimization intervention rct

Conditions: Obesity, Morbid

Summary: this study aims to identify if the addition of structured nutrition/weight loss counseling to patients at the bariatric clinic can increase the conversion from bariatric clinic to surgical candidacy from (the current) 11% to a goal of 20% by way of tracking their bia measurements.

obesity, at a bmi exceeding 40kg/m2 (class iii) obesity, is a major risk factor for osteoarthritis (oa). in arthroplasty (joint replacement), patients in this population are routinely turned away due to surgeons refusing surgical treatment in patients above arbitrary bmi thresholds (typically 35 or 40 kg/m2). due to this, patients often turn to simple weight loss to fall below these thresholds. simple weight loss, which can include loss of muscle mass, has been proven ineffective, counterproductive, and to be an additional risk factor for surgery. to combat this, efforts in our dedicated bariatric clinic have been made to encourage muscle mass gain and body fat loss over simple weight loss methods where progress has been tracked through stationary, multi-frequency bioimpedance analysis (bia). bia is a readily available technology offered to industry and consumers. our department is a novel clinic aimed at holistically serving the osteoarthritic-class iii obese population for controlled and monitored weight loss through bia. this study is a randomized controlled trial which aims to recruit adult patients with class iii obesity who present to the bariatric arthroplasty clinic. while all patients will receive individual body composition coaching to increase muscle mass and decrease body fat mass (as standard of care in this clinic), study participants will be randomly assigned to one of two cohorts: the study group who will receive nutritional and exercise consultation/intervention, or the control group who will only receive the individual body composition coaching that is standard practice at the bariatric clinic. this study aims to identify if the addition of structured nutrition/weight loss counseling to patients at the bariatric clinic can increase the conversion from bariatric clinic to surgical candidacy from (the current) 11% to a goal of 20% by way of tracking their bia measurements.

Eligibility criteria:
inclusion criteria: * adults, at or above 18 years of age * bmi over 40kg/m2 * presenting to arthroplasty-obesity clinic with desire for a total joint arthroplasty procedure exclusion criteria: * has a pacemaker or other electronic pacemaker placement * inability to stand unsupported for 60-90 seconds
the role of gut microbiome and chronic inflammation in young-onset colorectal cancer

Conditions: Colorectal Cancer

Summary: this study aims to investigate the role of gut microbiome pattern and inflammation marker nf-ҡb in young-onset colorectal cancer


Eligibility criteria:
inclusion criteria: 1. age ≥ 35 years old 2. suspected with colorectal cancer and undergoing a colonoscopy procedure 3. no history of colorectal cancer treatment exclusion criteria: 1. unwilling to provide fecal and blood sample 2. incomplete colonoscopy procedure due to any reasons

Keywords: chronic inflammation young-onset colorectal cancer gut microbiome ngs
evaluation of outcomes following lasik surgery using customvue

Conditions: Myopia; Astigmatism; Myopic Astigmatism

Summary: the aim of the study was to evaluate visual outcomes, contrast sensitivity, glare and induced high order aberrations induced by the new customvue software use for wavefront-guided lasik.


Eligibility criteria:
inclusion criteria: * myopia 0.00 to -6.00 d * astigmatism 0.00 up to -3.00 d * manifest refraction spherical equivalent (mrse) up to -6.00 d. exclusion criteria: * history of ocular pathology * previous ocular surgery * large pupils (greater than 8mm diameter, infrared measurement) * thin corneas (preoperatively calculated minimal residual bed \< 250 um) * irregular astigmatism * asymmetric astigmatism * unstable refraction * any other condition that precludes the patient from undergoing lasik
comparitive effectiveness of pme versus transthoracic echocardiogram (tte)

Conditions: Cardiac Disease

Summary: a new hand held pocket echo device (ge vscan) has now become available to clinicians, with limited data available comparing the effectiveness of this device as a screening tool when compared to traditional transthoracic echocardiography (tte). the investigators are evaluating the effectiveness of this hand-held echo (hhe) device in detecting cardiac pathology in a both an inpatient and outpatient clinical setting as compared to a comprehensive tte evaluation.

a new hand held pocket echo device (ge vscan) has now become available to clinicians, with limited data available comparing the effectiveness of this device as a screening tool when compared to tte. we are evaluating the effectiveness of this hhe device in detecting cardiac pathology in a both an inpatient and outpatient clinical setting as compared to a comprehensive tte evaluation. this study compares the images from the two modalities with regards to multiple parameters typically evaluated by traditional tte. this would include the following: 1. ejection fraction: estimates how well the heart is squeezing/functioning. 2. segmental wall motion abnormalities: if one wall of the heart is not moving well, this suggests that part of the heart is not getting enough blood supply and could represent a blockage in a blood vessel supplying the heart or in other terms a heart attack. 3. left ventricular end-diastolic dimension: allows us to see if the heart is dilated 4. inferior vena cava size: the size of this great vein can help estimate if patient has too much fluid in their vascular bed. 5. aortic valve pathology: whether or not there is thickening of the valve or impairment of it's opening. 6. mitral valve pathology: whether or not the valve is significantly thickened or with impaired closing and opening. 7. pericardial effusion: excessive fluid in the sack around the heart. the images obtained on the hhe will be evaluated by two experienced echocardiographers as well as two cardiology fellows who have obtained training in image acquisition and interpretation. the readers of the hhe images are blinded to the tte results, and vice versa. a comparison of these individual parameters on hhe and tte allows us to validate this new, convenient screening tool in detecting cardiac pathology.

Eligibility criteria:
inclusion criteria: 1. all subjects with an order for a routine transthoracic echocardiogram based on clinical indications. 2. vscan images will be obtained to evaluate multiple parameters (noted on research summary). 3. immediately after vscan imaging, a complete transthoracic echocardiogram will be performed. 4. images will be compared between the vscan device and the traditional transthoracic echocardiogram. exclusion criteria: 1. subjects who had a limited transthoracic echocardiography (i.e limited views) 2. vscan imaging not attempted for a certain parameter

Keywords: transthoracic echocardiogram hand-held echocardiography