Kornimate/medical-research-clean huggingface dataset:
phase i imaging study evaluating gem/cis or gem/carbo for participants with non-small cell lung cancer (mk-0000-083 am3)

Conditions: Carcinoma; Non-small Cell Lung Cancer

Summary: this study will use imaging to look at tumor response to combination chemotherapy of gemcitabine (gem) and cisplatin (cis) or gemcitabine and carboplatin (carbo) in non small cell lung cancer (nsclc).


Eligibility criteria:
inclusion criteria: * has histologically or cytopathologically confirmed metastatic or locally advanced stage iiib/iv non-small cell lung cancer (nsclc) * has measurable disease * has not been previously treated with surgery (involving the thorax), radiation (unless it was for a metastatic site), or chemotherapy for nsclc * is 18 years of age or older * has a performance status of 0-2 on the eastern cooperative oncology group (ecog) scale * women of childbearing potential have a negative pregnancy test exclusion criteria: * is participating in or has participated in a study with an investigational compound or device within 30 days or 5 half-lives of the start of treatment * has untreated brain metastases related to their nsclc or carcinomatous meningitis * abuses drugs or alcohol * is pregnant or breastfeeding * is human immunodeficiency virus (hiv) positive * has active viral hepatitis * has hearing loss * has poorly controlled diabetes mellitus * is allergic to gemcitabine, cisplatin or carboplatin
predictors of treatment failure pain among patients with mine-explosive wounds

Conditions: Chronic Pain

Summary: mine-explosive wounds in the general structure of combat sanitary losses reach 25%. they are characterized by significant damage resulting in high intensity pain. in patients who received mine-explosive injuries in the conditions of hostilities, such pain has its own unique features. it is necessary to pay more attention to the problem of pain treatment in patients of this category, because about 87.2% of cases have negative results of treatment - it becomes chronic.

the peculiarities of pain in patients with mine-explosive wounds depending on the localization of the wound at the stages of treatment need to be studied, because the subjective feelings and emotional experiences experienced by patients during the wounding in combat conditions through the prism of psychological disorders have their own characteristics. since in 87.2% of cases it is not possible to achieve a positive result of treatment, the data of our study will play an important role in their treatment.

Eligibility criteria:
inclusion criteria: * chronic pain, mine-explosive wounds exclusion criteria: * absence of mine-explosive wounds

Keywords: chronic pain, mine-explosive wounds
surgical treatment of liver hydatid cyst (surghida)

Conditions: Echinococcosis, Hepatic

Summary: the aim was to analyses the incidence and the independent factors associated with textbook outcome following surgical treatment of liver hydatid cysts (lhc).

textbook outcome (to) is a composite measure to determine the ideal postoperative period and to assess the quality of surgical care. the aim was to analyses the incidence and the independent factors associated with to following surgical treatment of liver hydatid cysts (lhc). the investigators conducted a retrospective cohort study of patients operated on for hepatic hydatidosis between january 2006 to december 2021. to occurred when all the following criteria were fulfilled: no mortality within 90 days, no major complications within 90 days, no reintervention within 90 days and no prolonged hospital stay. univariable and multivariable analyses were performed to identify factors associated with to.

Eligibility criteria:
inclusion criteria: * patients with liver hydatid cyst treated by total or partial pericystectomy exclusion criteria: * emergency surgery and simple drainage of cyst
the metaphyseal hip prosthesis - total hip

Conditions: Osteoarthritis of the Hip

Summary: the purpose of this study is to analyze stability, safety and efficacy of the metaphyseal hip prosthesis (mhp) compared to the stanmore hip replacement.

the purpose of this study is to analyze stability, safety and efficacy of the metaphyseal hip prosthesis (mhp) compared to the stanmore hip replacement at short term (1 year) and long term (10 years). bone remodeling will be analyzed at 10 years using dexa (dual energy x-ray absorptiometry (bone scan test)) measurements. this is a single-center prospective study with 25 patients in the study and 25 in the control group in open randomized clinical trial.

Eligibility criteria:
inclusion criteria: * candidates for a total hip replacement because of arthritis of the hip * patients with a good general condition * patients willing and able to participate in the clinical trial with a 10 years follow up and who have signed an inform consent * males and females * age between 55 and 75 * absence or little presence of osteoporotic bone (t\>-2) * asa score 1 and 2 exclusion criteria: * patient with co morbidities that limit the physical abilities which may negatively influence the scores. such co morbidities can for example be cardiac insufficiency or chronic respiratory diseases. * severe systematic diseases such as rheumatic arthritis and sle. * general osteoporosis (t\<-2). * hormonal conditions such as paget disease, which reduces the bone density. * diseases that can negatively influence the 10 years life expectancy. * chronic use of corticosteroids. * extreme overweight defined as bmi above 35. * active bacterial infection. * mental weakness which could negatively influence the postoperative recovery and influence the ability to complete pain scores and other questionnaires. * asa score \>2.

Keywords: osteoarthritis
ubiquinol as a metabolic resuscitator in post-cardiac arrest

Conditions: Cardiac Arrest

Summary: to study the effects of ubiquinol as a "metabolic resuscitator" in post-cardiac arrest.

cardiac arrest (ca) occurs in more than 400,000 patients in the united states each year with an estimated mortality of greater than 90%. the majority of patients who are resuscitated from ca will succumb to the neurologic morbidity associated with the post-ca syndrome and ischemic-reperfusion injury. currently, there are no pharmacologic agents known to offer survival benefit or to prevent devastating neurologic injury in post-ca patients. a potential therapeutic target following ischemia-reperfusion injury is mitochondrial function in the injured cell and/or reduction of oxygen free radicals. coenzyme q10 (coq10) is an essential mitochondrial co-factor and free radical scavenger that has been proposed as a neuroprotective agent in various neurodegenerative disorders as well as a cardioprotective agent. coq10 have furthermore shown exciting preliminary results as a potential therapy in post-ca. in order to test the effects of ubiquinol as a "metabolic resuscitator" in post-ca patients and to provide additional preliminary data for a large-scale clinical trial, the investigators are conducting a randomized, double-blind, place-controlled trial of ubiquinol in post-ca patients.

Eligibility criteria:
inclusion criteria: * adult (≥ 18 years) * cardiac arrest defined by cessation of pulse requiring chest compressions * not following commands after rosc * admission to the icu * naso/orogastric tube * ability to receive enteral medication exclusion criteria: * protected populations (pregnant women, prisoners, the intellectual disabled) * current coq10 supplementation * anticipated death within 24 hours * \> 12 hours from rosc to estimated randomization * jejunostomy tube (j-tube)
brief intervention to reduce drinking among batterers

Conditions: Intimate Partner Violence; Alcohol Use

Summary: the goal of this project is to examine whether, relative to standard care, violence and alcohol use outcomes can be improved by a brief, motivationally based adjunct alcohol treatment for men enrolled in batterer intervention programs. we hypothesize that men randomized to also receive the brief alcohol intervention will have better partner violence and alcohol use outcomes than men who are randomized to the batterer intervention program alone.


Eligibility criteria:
inclusion criteria: * participation in a batterer intervention program * hazardous drinking

Keywords: intimate partner violence alcohol use substance use
immune-pineal axis function in fibromyalgia

Conditions: Fibromyalgia

Summary: fibromyalgia is a common condition in clinical medical practice, characterized by diffuse musculoskeletal pain. sleep disorders, chronic fatigue, depression, intestinal disorders and headache are also commonly associated with the syndrome . although the etiology of this syndrome is not well defined yet, it means involve multiple mechanisms, including low levels of serotonin, increased substance p in cerebrospinal fluid and altered circadian variation in sympathetic - parasympathetic balance, consistent with changes in sympathetic hyperactivity at night . the immune - pineal system, formed by the integration of the adrenergic and immune systems pineal gland, appears to be involved in the genesis of the dysfunctions found in fibromyalgia. melatonin is secreted by the pineal gland and has promoter activity of sleep. studies show that melatonin and its precursors , serotonin and tryptophan are reduced in patients with fibromyalgia. the present study aims to evaluate the relationship of immune - pineal system in the process of fibromyalgia , since dysfunction of this axis appears to govern the cascading events that participate in the pathophysiological process of this disease.


Eligibility criteria:
inclusion criteria: * women 18-65 years old * fibromyalgia according to the criteria of the american college of rheumatology (wolfe 2010) * sign the informed consent * patients can take medication for chronic pain ( antidepressants , antiepileptics, for example), since there are at least two months exclusion criteria: * patients who did not understand the portuguese * diagnosis of malignancies, severe psychiatric disorders , sleep disorders not related to fibromyalgia (apnea , sleepwalking , restless leg syndrome), alzheimer's disease or any disease (rheumatologic, neurological, etc.) that can modify the evaluations or outcomes * alcohol abuse or drug addiction * patients who are performing acupuncture * bmi greater than 35 ( bmi = body mass index) . * patients with history of allergy to amitriptyline or/and melatonin or any other contraindication for the use of these drugs

Keywords: fibromyalgia melatonin amitriptylin imune-pineal axis
longitudinal mr imaging of pulmonary function in patients receiving thoracic radiation treatment

Conditions: Radiation Injury

Summary: the purpose of this study is to determine whether magnetic resonance imaging (mri) using inhaled hyper polarized xenon-129 (129xe) gas, and conventional contrast can help visualize impaired lung function and detect changes over time in patients receiving treatment as well as those who don't. 129xe is a special type of xenon gas and when inhaled during mri may be able to show areas of abnormal thickening of parts of the lungs. these images combined with images taken with injected contrast agents or other special types of mri such as conventional proton (1h) mri may provide a better way to look at lung structure and function. the ultimate goal is to predict the degree of radiation-induced lung injury that will develop in a given patient for a given treatment plan. the investigators anticipate that these images will provide more specific information about lung disease than standard lung function tests. the use of 129xe mri is investigational. investigational means that these tests have not yet been approved by the us food and drug administration and are only available in research studies like this one. in addition, standard mri with contrast is not typically done as standard of care for monitoring changes due to thoracic radiation therapy, therefore, its use in this study is also considered investigational. healthy volunteers are being asked to participate in this study because to develop a database of functional images that are representative of healthy lungs.


Eligibility criteria:
inclusion criteria for patients: 1. patient scheduled to undergo thoracic rt at duke university to a dose of at least 20 gy 2. willing and able to give informed consent and adhere to visit/protocol schedules exclusion criteria for patients: 1. subject is less than 18 years old 2. mri is contraindicated based on responses to mri screening questionnaire 3. subject is pregnant or lactating 4. respiratory illness of a bacterial or viral etiology within 30 days of mri 5. subject has any form of known cardiac arrhythmia 6. subject does not fit into 129xe vest coil used for mri 7. subject cannot hold his/her breath for 15 seconds 8. subject deemed unlikely to be able to comply with instructions during imaging 9. medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol requirements inclusion/exclusion criteria for healthy volunteers 1. subject meets all criteria above but does not have a clinical diagnosis of respiratory disease.

Keywords: radiation induced lung injury xenon gas hyperpolarized
11c-acetate for treatment response after radiotherapy for hcc

Conditions: Hepatocellular Carcinoma

Summary: it is thought that pet of the abdomen with 11c acetate will provide new information regarding whether or not patient's have benefited from radiotherapy. to test this theory, the project will evaluate the potential of 11c acetate to serve as an earlier and/or better signal of treatment success.


Eligibility criteria:
inclusion criteria: * \> 18 years of age * subject is willing to participate in the study and has signed the study informed consent * subject is available and willing to comply with the protocol evaluations * diagnosed hepatocellular carcinoma confined to a single lobe of the liver if undergoing 90y radioembolization * diagnosed hepatocellular carcinoma confined to the liver if undergoing stereotactic body radiation therapy (sbrt) * under consideration for 90y radioembolization or stereotactic body radiation therapy (sbrt) exclusion criteria: * pregnant or planning to become pregnant within the next 12 months or breast-feeding * gfr \< 45 * life expectancy \< 6 months * claustrophobic and cannot tolerate imaging procedures * weigh \> 350 lb (upper weight limit of scanner beds) * special vulnerabilities (e.g. fetuses, neonatales, pregnant women, children, prisoners, institutionalized individuals).
prospective study to assess disease activity and biomarkers in minority participants with relapsing multiple sclerosis (rms) after initiation and during treatment with ocrelizumab

Conditions: Multiple Sclerosis, Relapsing

Summary: open-label, prospective, single-arm, multi-center study to assess disease activity and biomarker of neuronal damage in minority patients (self-identified black or african american (aa) and hispanic/latino (ha) patients with relapsing multiple sclerosis (rms) receiving treatment with ocrelizumab. the study plans to enroll approximately 150 participants (75 aa and 75 ha) with 50 participants enrolled in a csf sub-study.


Eligibility criteria:
inclusion criteria: * diagnosis of rms with expanded disability status scale (edss) 0-5.5 at enrollment * participants who self-identify as black or african american or hispanic/latino american * treatment-naïve or initiating first or second switch from receiving treatment with certain disease modifying therapies (dmts) including interferon or glatiramer acetate or dimethyl fumarate (dmf); or siponimod; or fingolimod; or diroximel fumarate; or teriflunomide; or ozanimod; or natalizumab * for women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use acceptable contraceptive methods during the treatment period and for 6 months after the final dose of ocrelizumab * neurologically stable for at least 30 days prior to randomization and baseline assessments exclusion criteria: * diagnosis of secondary progressive ms without relapses for at least 1 year (nonactive or inactive spms) * primary progressive multiple sclerosis (ppms) * participants with contraindication to gadolinium based contrast agent for mri and participants who cannot tolerate mri procedure * infection related * cancer related * pregnant or lactating, or intending to become pregnant during the study * other medical conditions * known presence or history of other neurologic disorders * vaccinations: receipt of a live vaccine, or attenuated, or inactivated / component vaccine within 6 weeks prior to first administration of ocrelizumab * laboratory: abnormalities or findings at screening
antibody production following h1n1 influenza vaccination in organ transplant patients

Conditions: Organ Transplantation

Summary: organ transplant patients and staff members at the transplant institute have received pandemic h1n1 influenza vaccine (pandemrix) and specific antibody production was measured by haemagglutination inhibition according to the clinical guidelines and policy, respectively. this study retrospectively assessed the immune response after vaccination.

a total of 100 organ transplant patients and 36 healthy controls were included in the study. all individuals were vaccinated between october and november 2009 and received 2 doses of pandemrix. serum samples were collected at baseline before vaccination and 1 month after the first and second vaccination. individual hemagglutination-inhibiting serum antibody titers were measured.frequency of \> 4 -fold increase in antibody titers and seroconversion from non-protective prevaccination titers to protective postvaccination titers were recorded. adverse events were reported.

Eligibility criteria:
inclusion criteria: cohort number 1:organ transplant patients who were vaccinated and serum sample drawn at baseline. cohort number 2: staff members who were vaccinated and serum sample drawn at baseline. exclusion criteria: cohort number 1: organ transplant patients who were vaccinated and no serum sample drawn at baseline. cohort number 2: staff members who were vaccinated and no serum sample drawn at baseline.

Keywords: 2009 h1n1 influenza vaccine, organ transplant patients
dynamic vision testing and concussion management dream team 65

Conditions: Head Injury; Sport Injury; Concussion, Brain

Summary: the purpose of this study is to determine the value of including dynamic vision testing into california state university, northridge (csun) athletics' established concussion protocol. the study's hypotheses are 1) dynamic vision testing will reveal vision impairments right after a person sustains a concussion, 2) these impairments may still be present upon clearance to return to play.

the subjects of interest are csun student-athletes who give consent to participate in the study. dynamic vision will be assessed through the administration of the dynamic visual acuity (dva) test and the gaze stabilization test (gst). additionally, the 6-condition balance error scoring system (bess), which is currently a component of csun's established concussion protocol, will be administered to assess balance impairments. this cluster of tests will be administered three times per athlete: (1) during preseason to establish baseline measures, (2) acutely post-concussion once the athlete subject has been cleared by the team physician for return to exercise, and (3) when cleared to return to sport. the results will be used to evaluate whether or not dynamic vision results have returned to baseline by the time that csun athletics clears the athlete to "return to play."

Eligibility criteria:
inclusion criteria: * • california state university northridge athletes * participants are able to give consent to participate in the study * completion of preseason testing for the 6-condition, bess, dva, gst with the research team * sustained a concussion as diagnosed by the medical staff during the 2020-2021 season of play. * sampling of convenience on a volunteer basis exclusion criteria: * • athletes with preseason baseline tests on bess or dva that are not within the normative value range for an unimpaired individual. * the initial 6- condition bess score is \>20 errors * the subject is unable to attain a minimum of 85 degrees per second of horizontal head rotation when performing the dva test.
personal responsibility education program innovative strategies: digital initiative for youth

Conditions: Reproductive Health; Contraception; Sexually Transmitted Diseases

Summary: this randomized control trial (rct) will assess an innovative demonstration project to improve adolescent sexual and reproductive health among highly mobile and marginalized youth in fresno county, california. the digital initiative for youth intervention combines existing, in-person, group-based, comprehensive sexual health education with wraparound digital technologies. the technological component was designed by youth+tech+health using a "youth-centered" design approach and the intervention is implemented by fresno economic opportunities commission (fresno eoc). the university of california, san francisco is the external evaluator. the rct will assess health and behavioral outcomes at three time points (baseline, 4 months, 10 months).

the digital initiative for youth (diy) is an innovative, youth-centered, digital intervention that aims to improve the health and well-being of adolescents ages 13-19 in fresno county, california. in particular, it will address the needs of homeless and unstably housed youth, youth of color, sexual minority youth, and native american youth using a trauma-informed approach and positive youth development framework. diy combines existing, in-person, group-based, comprehensive sexual health education with an app designed in consultation with youth. diy is built on three strategies: positive youth development, youth-centered design, and wraparound technologies. it will focus on four main areas: sexual health and contraceptive use, healthy relationships, educational and career development, and life skills. the intervention includes six hours of in-person education and an app that includes a resource locator, goal setting, text message reminders, and additional information and referrals. this study is funded through the personal responsibility education program innovative strategies (preis), which is administered by the family and youth services bureau, part of health and human services, fresno eoc is responsible for site and participant recruitment as well as the implementation of the intervention. participants are randomized at the cohort (group) level. all control group participants will be invited to participate after completion of the long-term follow up period.

Eligibility criteria:
inclusion criteria: * speak/understand spanish or english * live within fresno county, california at baseline (may move out afterward) * age between 13-19 * have access to a smart phone or internet (does not need to own) exclusion criteria: * do not live in fresno county, california at baseline * do not speak or understand spanish or english * severe mental health issues that prevent them from participating

Keywords: youth adolescent