Kornimate/medical-research-clean huggingface dataset:
effect of reiki application on menopausal symptoms

Conditions: Menopausal Symptom

Summary: in this randomized controlled study, it was aimed to determine the effect of distant reiki on menopausal symptoms. two different hypothesis teams have been established for the study. these; h0: there is no significant difference between the menopause rating scores of the women in the study group in which distant reiki was applied and the control group without distant reiki. h1: there is a significant difference between the menopause rating scores of the women in the study group in which distant reiki was applied and the control group without distant reiki.

parallel to the increase in life expectancy by years, the population of women living in the post-menopausal period is also increasing. in order to have a healthy menopause, which is an important part of women's life, it is thought that the distant reiki without health risks by women may be effective in reducing the symptoms of menopause experienced by women. in line with this information, it was aimed to determine the effect of distant reiki on menopausal symptoms. the study was carried out with menopausal women between the ages of 40-55 in adana province in turkey. therefore, in the study, 48 women in the menopausal period between the ages of 40-55 was randomly assigned to reiki and control groups. distant reiki application for 30 minutes three times a week for four weeks was applied individually to the study group. no intervention was made to the control group for a period of four weeks. the primary expected outcome of the research is the effect of distant reiki on menopausal symptoms of menopausal women. results was applied three times in total, before the study and control application, 4 weeks and 8 weeks later.

Eligibility criteria:
inclusion criteria: * willing to participate in research, * can read and write in turkish, * open to communication, * those who are between the ages of 40-55 and do not experience menstruation for at least one year, * experiencing at least one or more of the menopausal symptoms, * not applying regular reiki, * those who have not surgically entered menopause, * women without psychiatric problems exclusion criteria: * who do not agree to participate in the research, * can't read and write turkish, * communication is not possible, * those who are younger than 40, older than 55, have experienced menstruation for at least one year, * do not experience the symptoms of menopause, * using medication for the treatment of menopausal symptoms, * chronic illness, * regular reiki is applied, * surgically in menopause, * women with psychiatric problems

Keywords: nursing integrative practice menopausal symptoms reiki
adrenaline for the treatment of no-reflow in normotensive patients

Conditions: Acute Coronary Syndrome; No-Reflow Phenomenon; Normotensive

Summary: no-reflow is defined as the lack of myocardial perfusion despite opening of the epicardial coronary vessels in the setting of percutaneous coronary intervention (pci). it has been demonstrated that either impaired flow or the absence of flow is associated with an increased rate of mortality. among available treatment options, intracoronary adenosine is widely used in clinical practice, moreover, adrenaline is a safe alternative for the cases where use of adenosine is limited due to presence of hypotension or bradycardia. nonetheless, evidence from retrospective and observational studies suggest that intracoronary adrenaline is well tolerated and may exert encouraging effects in prompt recovery of flow in these patients. however, very limited data are available on efficacy of intracoronary (ic) adrenaline in normotensive patients. therefore, this study is planned to study the hypothesis that; intracoronary adrenaline is safe and has significantly higher efficacy as compared to adenosine for the treatment of no-reflow in normotensive patients with acute coronary syndrome.


Eligibility criteria:
inclusion criteria: * all patients with acute coronary syndrome who developed no-reflow during pci. * patients with systolic blood pressure of \> 100 mmhg. exclusion criteria: * hypotensive patients * patients with valvular or congenital heart disease. * patients with atypical chest pain * patients with cardiomyopathy * patients with pericarditis * patients with myocarditis * patients refused to give consent
covid-19 in art: perception and experience

Conditions: COVID19; Fertility Issues; ART

Summary: non-urgent medical care, such as fertility treatments, has been massively postponed during the past weeks due to the covid19 pandemic. the lockdown and the closure of ivf centers might cause anxiety and depression among infertile couples, who are already exposed to the distressing experience of infertility and for whom the wait for a baby already appears unending. few data are available regarding the impact of sars-cov-2 on pregnant women and foetus, or on fertility. this study aims to assess the views of infertile couple regarding the potential risks of covid during their fertility treatment and their personal experience of the covid pandemic and their expectation for further treatment .


Eligibility criteria:
inclusion criteria: - men and women who had a fertility treatment prescribed during the past 9 months in our fertility department exclusion criteria: * patient attending for a fertility preservation * patient attending for a preimplantation genetic testing (pgt-m or pgt-sr) * patient not fluent in french

Keywords: fertility risk perception emotional experience
medex hidden valley 2008

Conditions: Hypoxia

Summary: during a multi-week expedition to the himalaya, we aim to investigate i) whether dietary supplementation with carbohydrate drinks and gels can improve physical performance; and ii) the underlying mechanisms for any observed changes in performance. we hypothesise that i) carbohydrate supplementation will improve physical performance; and ii) the underlying mechanism of this improvement in performance will include maintenance of body glycogen (sugar) stores, prevention of dehydration and decrease in the incidence of acute mountain sickness.


Eligibility criteria:
inclusion criteria: * a healthy enthusiasm for the outdoors and/or a passion for research in remote and difficult circumstances exclusion criteria: * persons with phenylketonuria

Keywords: acute mountain sickness body composition,hypoxia carbohydrate supplementation expedition, hydration, hypoxia performance
efficacy of ciclesonide inhaled once daily versus fluticasone propionate inhaled twice daily in children with asthma (4 to 15 y) (by9010/m1-205)

Conditions: Asthma

Summary: the aim of the study is to compare the efficacy of ciclesonide versus fluticasone propionate on lung function, symptoms, and use of rescue medication in children with persistent asthma. ciclesonide will be inhaled at one dose level once daily; fluticasone propionate will be inhaled at one dose level twice daily. the study duration consists of a baseline period (2 to 4 weeks) and a treatment period (12 weeks). the study will provide further data on safety and tolerability of ciclesonide.


Eligibility criteria:
main inclusion criteria: * history of persistent bronchial asthma for at least 6 months * fev1 50-90% of predicted main exclusion criteria: * concomitant severe diseases or diseases which are contraindications for the use of inhaled steroids * copd (chronic bronchitis or emphysema) and/or other relevant lung diseases causing alternating impairment in lung function * respiratory tract infection or asthma exacerbation within the last 30 days prior to entry into the study * history of life-threatening asthma * premature birth * current smoking * smoking history with either equal or more than 10 pack-years * pregnancy * intention to become pregnant during the course of the study * breast feeding * lack of safe contraception

Keywords: asthma ciclesonide child fluticasone propionate pediatric
analgesic effects of ultrasound-guided dry-needling therapy for neck and head pain

Conditions: Neck Pain; Head Pain

Summary: the analgesic effects of ultrasound-guided dry-needling therapy will be evaluated in the management of head and neck pain.

the analgesic effects of ultrasound-guided dry-needling therapy will be evaluated in the management of head and neck pain by myofascial active and latent trigger point. the myofascial pain control will be assessed for the superficial and deep posterolateral muscle complex of neck. the analgesic request, range of motion (rom), motion related pain (mrp) and the quality of life, will be also assessed.

Eligibility criteria:
inclusion criteria: * chronic neck pain * chronic head pain exclusion criteria: * previous surgery of neck and head * body mass index \> 39,99 * politrauma patients * pregnancy * neck and head infections

Keywords: pain
study of the effectiveness of "fesia grasp": functional electrical stimulation device for upper limb rehabilitation after stroke

Conditions: Stroke; Upper Extremity Paresis

Summary: the purpose of this study is to evaluate the effectiveness of fesia grasp, a functional electrical stimulation device for the rehabilitation of upper limb in post-stroke patients. fesia grasp rehabilitation will be compared with usual care rehabilitation of upper limb. * experimental group: patients will receive fesia grasp therapy (intensive, repetitive and functional exercises assisted by functional electrical stimulation) * control group - patients will receive standard care.


Eligibility criteria:
inclusion criteria: * 18 years old or older subjects with hemiparesis in the upper limb after stroke, which have been referred to the rehabilitation unit of the reina university hospital. * unilateral paresis * cognitive ability to assimilate and actively participate in the protocol of evaluation and treatment exclusion criteria: * very severe proximal spasticity: ashworth \> 3. * psychiatric illness (including post-stroke depression). * cognitive impairment. * inability to provide informed consent. * other severe medical problems. * severe hemi-spatial neglect or anosognosia involving the affected arm. * pacemakers * pregnant women. * skin ulcers. * peripheral neuropathies. * edema of the affected forearm and / or hand. * severe pain.

Keywords: stroke upper extremity paresis functional electrical stimulation
adherence to prescribed medication: elucidating the gap between guideline recommendation and real life in myocardial infarction

Conditions: Myocardial Infarction; Adherence, Medication

Summary: the aim of the study is to investigate the adherence to prescribed post-infarction medication and to cardiac rehabilitation in patients after acute myocardial infarction. in addition, their impact on cardiovascular events will be investigated.


Eligibility criteria:
inclusion criteria: * acute myocardial infarction * willingness to participate exclusion criteria: * inclusion in an interventional study interfering with standard of care medication
a study of ly3023703 testing pain relief after wisdom teeth removal

Conditions: Acute Pain

Summary: the main purpose of this study is to test if a single dose of ly3023703 relieves pain after wisdom teeth removal. the study will last about one week for each participant, not including screening.


Eligibility criteria:
inclusion criteria: * have at least 2 third molars which are clinically indicated for extraction. at least 1 molar should be a mandibular third molar with partial or complete bony impaction * are overtly healthy as determined by medical history and limited physical examination exclusion criteria: * have chronic pain \[for example (e.g.), fibromyalgia\] or are experiencing episodic pain not related to the wisdom teeth (e.g., migraine pain) that could affect pain measurements as judged by the investigator * have temporomandibular joint disease or other condition which could affect pain processing or sensation, affect recovery from dental surgery, or otherwise affect ability to assess pain signal, in the opinion of the investigator * have substantial anxiety regarding dental or medical procedures as measured by the corah dental anxiety scale * are currently using or have recently used drugs that may confound assessment of the inflammatory response or pain including, but not limited to, nonsteroidal anti-inflammatory drugs (nsaids), aspirin and other analgesics, antihistamines, steroids, antidepressants, attention-enhancing drugs, or herbal supplements

Keywords: wisdom tooth extraction
efficacy of aesybite active in reducing sleep bruxism activity

Conditions: Sleep Bruxism

Summary: the overall objective of the clinical investigation is to evaluate whether the use of the aesybite active reduces the bruxism activity.


Eligibility criteria:
inclusion criteria: * age 18 to 70 years, in good general health. * presence of at least one of the following: * sleeping partner's report of tooth grinding sounds during sleep for at least three nights per week within the last 6 months, * hypertrophy of the masseter muscle upon digital palpation. * presence of at least one of the following: * signs of tooth attrition or shiny spots on dental restorations, * self-report of masticatory muscle fatigue or pain at awakening. * previous prescription of a night splint for bruxism. * able to understand and follow the protocol and complete the self-administered paper questionnaires. * able to provide written informed consent to study participation and storage and processing of study data exclusion criteria: * allergic to ethylene-vinyl acetate (eva) copolymer. * with more than two missing molars (excluding third molars). * ongoing orthodontic treatment (e.g. teeth alignment). * with major neurological or psychiatric disorders including substance dependence. * using a removable dental prosthesis. * using a medication with known effects on sleep or motor behavior. * suffering from periodontal disease. * with occlusal or jaw abnormalities that prevent the wearing of a normal dental splint. * participants with pacemakers.
study of variables related to the discontinuation of mechanical ventilation in patients with head injury

Conditions: Traumatic Brain Injury; Weaning Failure; Mechanical Ventilation Complication

Summary: the purpose of this study is to evaluate physiological variables to the decision about the appropriate time to discontinuation of mechanical ventilation in patients with traumatic brain injury. it is expected that these variables are effective in predicting the outcome of weaning from mechanical ventilation.

the aim of this study is to evaluate the effectiveness of integrated pressure index of airway occlusion x index breathing fast and shallow (p 0.1 x f/vt) in predicting success and failure of weaning from mechanical ventilation in patients with traumatic brain injury.

Eligibility criteria:
inclusion criteria: * traumatic brain injury (tbi) * patients using artificial airway (intubation and / or tracheostomy) * recovery from the acute phase of the disease underlying * both sexes * ventilation mode pressure support (psv), pressure support (ps) required to ensure a tidal volume (vt) = 6 to 8 ml / kg * age over 18 years * hemoglobin \> 7 g/dl * duration of mechanical ventilation longer than 24 hours * body temperature \< 38 degrees * ph ≥ 7.30 * pao2 ≥ 60 mmhg with fio2 ≤ 0.4 and peep ≤ 8 cmh2o * glasgow coma scale ≥ 8 or tracheostomized * sedative agents minimum dosages to to maintain values of 2 or 3 on the ramsay scale exclusion criteria: * admitted to the icu with artificial airways held in other institutions * surgery scheduled for the next 72 hours * withdrawal of consent from parents at any stage of the research

Keywords: keywords provided by atlantic health system: rapid shallow breathing index mechanical ventilation additional relevant mesh terms: respiration disorders traumatic brain injury weaning failure mechanical ventilation complication
virtual reality 3d-surgery modeling to enhance head and neck cancer surgery quality

Conditions: Head and Neck Squamous Cell Carcinoma

Summary: this clinical trial studies the use of virtual reality technology and three dimensional surgery (3d-surgery) modeling to enhance current treatments in head and neck cancer surgery. virtual reality 3d-surgery modeling may improve quality of surgical planning and interdisciplinary communication between surgeons and pathologists during the treatment of head and neck squamous cell cancer and ultimately increase the accuracy of planning, the quality of communication, and maximize the outcome patients with head and neck cancer experience throughout treatment.

primary objectives: to assess the potential for preoperative virtual reality and 3d pathological modeling to reduce total number of margin events as defined in the study as the number of positive frozen margins, number of positive final margins and the number of unexpected defect driven margins. secondary objectives: to assess the impact of preoperative virtual reality and 3d pathologic modeling as treatment for head and neck squamous cell carcinoma on event free survival (efs) at 18-36 months after resection as defined by recurrence at the primary site. tertiary objective: i. to evaluate the quality of existing interdisciplinary intraoperative communication using the proposed vr/3d-case enhancement protocols (ceps) as an evaluating medium. outline: patients are randomized to 1 of 2 arms. arm i (vr/3d-ceps + standard treatment): prior to surgery (day 0-13), patients undergo virtual reality 3d tumor resection via vr/3d-ceps. patients' pre-surgical computed tomography (ct) scans are reviewed per standard of care. patients then undergo surgical resection on day 14-29 and a 3d model of true tumor is created and imported into the virtual reality environment. arm ii (standard treatment): prior to surgery (day 0-13), patients' pre-surgical ct scans are reviewed per standard of care. patients then undergo surgical resection on day 14-29. after completion of study intervention, patients are followed for up to 36 months.

Eligibility criteria:
inclusion criteria: * diagnosed with cancer of the head and neck (oral cavity, oropharynx, larynx, hypopharynx, t1-t4) * receiving treatment at thomas jefferson university - center city by a fellowship-trained hnc surgeon * eligible for definitive resection * age \> 18 * provide signed written informed consent document exclusion criteria: * impaired judgement or those unable to provide informed consent * any factor that would place the patient at increased risk or preclude the individual's full compliance with or completion of the study * nasopharyngeal carcinoma * contraindications for surgery * enrollment in other clinical trial
decision-making - the benefit of bedside crp within ambulance care

Conditions: Critical Illness

Summary: patients with degreased (dgc) for ambiguous reasons receive low triage priority. their death risk is triple. tools are needed to identify the critically ill patients from this group. the triage used today is not effective. the bedside point-of-care measurements are crp, lactate acid and supar (soluble urokinase plasminogen activator receptor). elevated values associate with the probability of critical illness and predict a risk of death.

purpose: to improve identification and proper prioritization of patients with non-specific symptoms prehospitally, we intend to investigate whether q-crp, a rapid test for crp, correlates with time-critical states in the above-mentioned patient group alone or together with crp, lactate and supar. the primary endpoint is need for hospital care. material: patients over 18 years who exhibit non-specific symptoms and transported to the emergency room. method: in patients with unspecified conditions, defined according to the inclusion template, a venous blood sample was taken prehospitally at the scene by the ems. analysis: significance tests and regression analyzes with 95% ci were used. the diagnostic accuracy of q-crp, lactate, supar and combinations thereof were compared with optimal boundary values.

Eligibility criteria:
inclusion criteria: * patients over 18 years who exhibit non-specific symptoms and transported to the emergency room. exclusion criteria: * abnormal vitals

Keywords: q-crp lactate supar poc ambulance
the influence of cyp2c19 polymorphism and clinical outcomes in stroke patients

Conditions: Platelet Aggregation Inhibitors

Summary: background: clopidogrel, an antiplatelet prodrug, is widely used for prevention of the recurrent cardiovascular events. cyp2c19 is one of the crucial enzymes for the activation of clopidogrel. recent studies, mostly done in cardiovascular patients, showed association of the cyp2c19 genotypes with recurrent cardiovascular events. however, prospective data on the impact of the genetic variants in stroke patients are limited. methods: five hundred and eighteen japanese non-acute stroke patients treated with clopidogrel were registered at 14 institutions. three cyp2c19 variants (cyp2c19\*2, \*3, \*17) were genotyped and the patients were classified into three clopidogrel metabolizer groups inferred from the cyp2c19 genotypes: extensive (em: \*1/\*1), intermediate (im: \*1/\*2 or \*1/\*3), and poor (pm: \*2/\*2, \*2/\*3, or \*3/\*3). the cyp2c19\*17 carriers were excluded from the analysis. the antiplatelet effects of clopidogrel were assessed by adenosine diphosphate (adp) -induced platelet aggregation and vasodilator-stimulated phosphoprotein (vasp) phosphorylation, expressed as vasp index. the endpoint was the composite incidence of stroke, transient ischemic attack, myocardial infarction, revascularization, other thromboembolic disease, or cardiovascular death during 2 years of follow-up.


Eligibility criteria:
inclusion criteria: * patients who had received long-term clopidogrel therapy (once a day for at least one month) with a minimum one-month interval between enrollment and the last cerebral ischemic or tia event. * males and females aged 20 years or older who were prescribed clopidogrel for the secondary prevention of cerebral infarction or transient ischemic attack and who were willing and able to give written informed consent. exclusion criteria: * malignancies * congenital bleeding tendency * atrial fibrillation * concomitant use of an oral anticoagulant agent * a platelet count of \ 450 x 109/l within 3 months of enrollment * modified rankin scale \> 4