Kornimate/medical-research-clean huggingface dataset:
ultrasound guided rhomboid intercostal block for myofascial pain syndrome

Conditions: Myofascial Pain Syndrome

Summary: rhomboid intercostal block (rib) is an interfacial plane block described in 2016. it creates analgesia at t2-t9 levels in the hemithorax by applying local anesthetic to the fascia between the rhomboid muscle and the intercostal muscle. it has been used effectively in patients with chronic pain. recently published report has shown that rhomboid intercostal block (rib) may provide effective pain control for myofascial pain syndrome (mps), too. mps is a regional pain syndrome characterized by trigger points detected in one or more regional muscle groups. the investigators planned a prospective observational study, a total of 30 patients who will apply to our clinic with mps, will register in research. the investigators will perform ultrasound-guided rib, and evaluate the clinical outcomes.

myofascial pain syndrome (mps) is the most common cause of musculoskeletal pain and its prevalence in the population is reported to be 21-30%. rhomboid intercostal block (rib) is an interfacial plane block described in 2016. it creates analgesia at t2-t9 levels in the hemithorax by applying local anesthetic to the fascia between the rhomboid muscle and the intercostal muscle. it has been used effectively in patients with chronic pain. the investigators planned a prospective observational study.from february to march 10 2021, a total of 30 patients who will apply to our clinic with mps, will register in research. the investigators will perform ultrasound-guided rib, and evaluate the clinical outcome ultrasound guided rib will applied with linear probe, in plane technique. block needle was inserted to plane between the rhomboid muscle and intercostal muscles over the t5-6 ribs 2 cm to 3 cm medially from the medial border of the scapula. 13ml of bupivacaine 0.25% and 8mg dexamethasone mixture will inject into the fascial plane. numerical rating scale (nrs) will recorded before and after the block at 30 minutes, day 1, 1-2-4-6 weeks.

Eligibility criteria:
inclusion criteria: * complaint of myofascial pain * pain that is rated at least 3 on a numerical rating scale (nrs, 0 = no pain, 10 = the worst pain) exclusion criteria: * pregnancy * the presence of coagulopathy, or the use of anticoagulants * a history of surgery on the block area * allergic to bupivacaine * decline to participate

Keywords: rhomboid intercostal block ultrasound guided block
how does the mood of the patients change before and after the invasive urodynamic study?

Conditions: Lower Urinary Tract Symptoms; Mood Change; Diagnosis

Summary: the goal of this study is to learn about the patient's perspective regarding to psychological mood before and after an invasive urodynamic study.

the participants have already had an indication of an invasive urodynamic study. all patients will be given stai, perceived stress scale and vas forms just before, after and 1-week following an invasive urodynamic study. the scores will be compared.

Eligibility criteria:
inclusion criteria: * patients with an invasive urodynamic study indication exclusion criteria: * non-turkish speakers * poor conscious state

Keywords: invasive urodynamic study mood
real-world evidence study on the performance and safety of halova ovules

Conditions: Vaginal Atrophy

Summary: an open-label, multicentric, non-randomized, single-arm, pilot, interventional clinical investigation to confirm the tolerability and performance of the medical device halova in lubrication of the vagina and vaginal atrophy treatment.

the primary objective of this investigation is to evaluate the therapeutic performance and tolerability of halova ovules in treating vaginal atrophy and restoring the natural lubrication of the vaginal mucosa. the secondary objective of this clinical investigation are to evaluate the performance of the medical device by clinical examination, and the degree of patient satisfaction related to the intended use (likert scale).

Eligibility criteria:
inclusion criteria: * adult women, aged between 18 and above, in pre-menopause or menopause; * adult women with atrophic vaginitis caused by estrogen hormone deficiency; * adult women who have vaginal dryness as a result of contraceptive treatment or other disorders; * subjects with a normal cervical cytology report, e.g. negative for intraepithelial lesions or malignancy (nilm) or slightly changed to atypical squamous cells of undetermined significance (asc-us) in the last 6 months; * subjects willing to provide signed informed consent for participation in clinical investigation. exclusion criteria: * subjects with vulvar or cervical cancer.

Keywords: dyspareunia dysuria vaginal lubrication
effects of face masks during exercise

Conditions: Cardiopulmonary; Exercise; Cognitive Performance; Covid19

Summary: to describe the primary and secondary outcomes of athletes during a cardiopulmonary exercise test (cpet) on a cycle ergometer with and without a face mask.


Eligibility criteria:
inclusion criteria: * be able to come to baylor scott \& white sports therapy and research at the star in frisco, texas twice in three weeks. * be willing to wear a face mask during exercise capacity testing on a stationary bicycle. exclusion criteria: -
safety study of the effects of inhaled fluticasone furoate/gw642444 on the hypothalamic-pituitary-adrenal (hpa) axis

Conditions: Asthma

Summary: the purpose of this study is to assess the effect of six weeks' treatment with two once-daily strengths of fluticasone furoate/gw642444 inhalation powder on the hpa axis system


Eligibility criteria:
inclusion criteria: * outpatient with ability to comply with study requirements and complete two 24-hour clinic visits * clinical diagnosis of asthma for greater than/equal to 12 weeks * reversibility fev1 of at least twelve percent and two hundred milliliters * fev1 greater than or equal to fifty percent of predicted exclusion criteria: * history of life threatening asthma * respiratory infection or oral candidiasis * asthma exacerbation * uncontrolled disease or clinical abnormality * allergies to study drugs, study drugs' excipients, medications related to study drugs * taking another investigational medication or prohibited medication

Keywords: hpa axis
pathology analysis of opmd patient myotomies

Conditions: Oculopharyngeal Muscular Dystrophy

Summary: the study aims to characterize the effect of opmd mutation on muscle function. muscle samples will be received from oculopharyngeal muscular dystrophy (opmd) patients who undergo cricopharyngeal muscle-cutting surgery, as part of their routine healthcare and treatment.


Eligibility criteria:
inclusion criteria: * opmd patients both male and female. * opmd patients between the ages 18-70 years. * opmd patients who are referred to the cricopharyngeal muscle-cutting surgery as part of their usual treatment. exclusion criteria: • opmd patients not referred to the cricopharyngeal muscle-cutting surgery as part of their usual treatment.
effect of weight loss on intermuscular adipose tissue (imat) signaling

Conditions: Obesity; Insulin Sensitivity; Muscle Weakness; Adiposity; Insulin Resistance

Summary: the goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (imat) in individuals with obesity. the main question it aims to answer is how inflammatory molecules secreted by imat promote muscle insulin resistance and inflammation, and how these same molecules are diminished after weight loss. following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss. after 12 weeks, this will be followed by the same testing and biopsies that were completed before the intervention. researchers will then compare outcomes of individuals who lost weight to individuals who did not lose weight.


Eligibility criteria:
inclusion criteria: * generally healthy men and women aged 18-70 * bmi between 30-40 * less than 1 hour of exercise per week * women: 1. may be pre or post menopausal exclusion criteria: * type 1 or type 2 diabetes * thyroid disease * history of lung disease * active use of nicotine * severe plasma lipid disorders * taking hormone replacement drugs, blood thinners, or thiazoladinediones * women: 1. currently going through menopause or peri-menopause 2. pregnant or breastfeeding 3. history of polycystic ovary syndrome

Keywords: imat intermuscular adipose tissue weight loss diet
long-term study of the press fit condylar (p.f.c.) sigma total knee replacement system

Conditions: Knee Osteoarthritis

Summary: the main purpose of this study is to record information from clinical and radiographic examinations and patient assessment questionnaires before surgery and at suitable postoperative intervals to assess the functioning and symptomology of each knee following surgery. in addition, any adverse events or complications are to be recorded, and any device failures or early revisions are to be recorded and reported directly to the sponsor. the data are to be used in an evaluation of the performance of the p.f.c. sigma knee implants over a minimum of 5 years.

the primary outcome measures are detailed above in the brief summary. secondary outcomes are any adverse events or complications and any device failures or early revisions to be recorded and reported.

Eligibility criteria:
inclusion criteria: * patients who have given voluntary written informed consent to participate in this study. * patients for whom primary total knee replacement is indicated due to degenerative joint disease, including rheumatoid arthritis, osteoarthritis, avascular necrosis, and post-traumatic arthritis, which is causing pain, deformity, or limitation of function uncontrolled by medical treatment. * patients who, in the opinion of the investigator, are able to understand this study, co-operate with the investigational procedures and are willing to return to the hospital for all the scheduled post-operative follow-ups. * male or female patients who are skeletally mature and for whom an appropriate size of device is available. exclusion criteria: * patients scheduled for revision total knee arthroplasty, or who have had previous surgery to their knee except menisectomy, arthroscopy or synovectomy. * patients experiencing any condition that may, in the opinion of the investigator, interfere with the total knee replacement's survival or outcome (e.g. paget's disease, charcot's disease, severe osteoporosis, etc.) * patients who have evidence of active infections which may spread to other areas of the body (e.g. osteomyelitis, pyrogenic infection of the knee joint, overt infection, etc.). * patients who are currently participating in any other clinical investigation of a device or pharmaceutical. * patients having non-contained defects in the tibia or femur necessitating bone graft. * patients with psychosocial disorders that would limit rehabilitation or follow-up. * subjects with a known history of poor compliance to medical treatment. * subjects who are known drug or alcohol abusers. * other contraindications for the use of the p.f.c. ® s knee system as listed in the package insert.

Keywords: arthroplasty, replacement, knee, p.f.c. sigma rpf, sigma rp
speech as biomarker for emotion, movement and cognition in parkinson's disease

Conditions: Parkinson Disease

Summary: with this study, the investigators want to investigate whether computerized speech analysis can be used to reliably and objectively detect motor, emotional, and cognitive fluctuations in parkinson's disease patients.

parkinson's disease (pd) affects mobility (motor function), thought processes (cognition) and mood (emotion). the language is one of the most complex programs in humans. it contains information about mobility, thinking and mood at the same time. these three levels of agility, thinking and mood are subject to spontaneous fluctuations and can be influenced by external stimuli such as pictures that induce emotions. in addition, these three levels are influenced on the one hand by parkinson's disease itself, and on the other hand by its treatment with medication or with deep brain stimulation (dbs). for this reason, the investigators would like to investigate language in parkinson's disease patients in a very detailed computerized way for motor, cognitive and emotional elements for better management of therapies. with this study, the investigators want to investigate whether computerized speech analysis can be used to reliably and objectively detect fluctuations in motor, mood, and thinking in parkinson's disease patients. even in healthy subjects, speech changes in a situational manner, due to which the investigators will also include healthy subjects as a control group.

Eligibility criteria:
patients with parkinson's disease inclusion criteria: * written informed consent * idiopathic pd according to the movement disorders society criteria; * age of participants \> 30 and ≤ 75 years; * treatment with or without bilateral deep brain stimulation in the subthalamic nucleus; * fluent in german or french exclusion criteria: * dysarthria caused in addition by a condition other than pd (e.g. stroke, myasthenia); * clinical diagnosis of aphasia; * brain disease other than parkinson's disease (e.g. atypical parkinsonism, alzheimer's disease, vascular dementia, multiple sclerosis, stroke, traumatic brain injury, epilepsy, etc.). * cognitive impairment (montreal cognitive assessment (moca) \< 24/30 points); * depression with acute suicidal ideation healthy controls inclusion criteria: * written informed consent * adults from 50-70 years old; * fluent in german or french exclusion criteria: * diagnosis of parkinson's disease; * cognitive impairment (montreal cognitive assessment (moca) \< 24/30 points); * suffering from brain disease (e.g. atypical parkinsonism, alzheimer's disease, vascular dementia, multiple sclerosis, stroke, traumatic brain injury, epilepsy, etc.); * clinical diagnosis of aphasia, dysarthria, and stuttering; * suffering from or diagnosed with psychiatric illnesses according to dsm-v criteria

Keywords: speech emotion movement cognition biomarker automated speech analysis
compression of the lid margin increase microbial contamination risk of patients undergoing cataract surgery

Conditions: Cataract

Summary: to investigate whether compression of the lid margin increase microbial contamination risk of patients undergoing cataract surgery


Eligibility criteria:
inclusion criteria: * (1) age \> 60 years; (2) clinical diagnosis of age related cataract, without previous recent ocular surgery; (3) undergoing phacoemulsification with implantation of intraocular lens ; (4) able to give informed consent. exclusion criteria: * (1) any inflammation of the eye or other parts of the body within the previous 3 months; (2) chronic use of any types ophthalmic medication; (3) contact lens wear; (4) ocular surgery within the past 3 months; (5) use of systemic antibiotics within 30 days; (6) use of eyedrops in either eye within 3 days of enrollment; (7) need for concurrent glaucoma, cornea or other surgery.
cannabis for inflammatory bowel disease

Conditions: Crohn's Disease; Ulcerative Colitis

Summary: background: the marijuana plant cannabis has been used for centuries in the medicinal treatment of many disorders and is still the subject of medical research and public debate. cannabinoids have been purported to alleviate a variety of neurological conditions such as ms-related symptoms including spasticity, pain, tremor and bladder dysfunction. other neurological conditions like chronic intractable pain, dystonic movement disorders and tourette's syndrome were all reported to be alleviated by cannabis use. cannabis has been used to treat anorexia in aids and cancer patients. in gastroenterology cannabis has been used to treat symptoms and diseases including anorexia, emesis, abdominal pain, gastroenteritis, diarrhoea, intestinal inflammation and diabetic gastroparesis. cannabinoids have also a profound anti inflammatory effect, mainly through the cb2 receptor. cell mediated immunity may be impaired in chronic marijuana users. and a potent anti-inflammatory effect of cannabis was observed in rats . studying the functional roles of the endocannabinoid system in immune modulation reveals that there are no major immune events which do not involve the endocannabinoid system. cannabinoids shift the balance of pro-inflammatory cytokines and anti-inflammatory cytokines towards the t-helper cell type 2 profiles (th2 phenotype), and suppress cell-mediated immunity whereas humoral immunity may be enhanced. they are therefore used for various inflammatory conditions including rheumatoid arthritis and asthma. in a mouse model of colitis cannabinoids were found to ameliorate inflammation and there are many anecdotal reports about the effect of cannabis in inflammatory bowel disease. however, there are no methodical reports of the effect of cannabis on inflammatory bowel disease. the aim of the proposed study is to examine in a double blind placebo controlled fashion the effect of smoking cannabis on disease activity in patients with ibd.


Eligibility criteria:
inclusion criteria: 1. patients with a diagnosis ibd at least 3 months before recruitment will be eligible to the study. 2. patients with active disease who are resistant to either 5 asa, steroids or immunomodulators, or who can not receive those drugs due to adverse reactions will be offered the possibility of smoking cannabis at a dose of two cigarettes a day which will contain either regular cannabis or pre treated cannabis as placebo. 3. disease activity index of either cdai of more then 200 in crohn's disease or mayo score above 3 in uc. 4. age above 20. exclusion criteria: 1. patients with a known mental disorder 2. patients who are deemed to be at a high risk of abuse or addiction to the study drug. 3. pregnant women 4. patients who are sensitive to any of the ingredients of the study medication. 5. patients who are unable to give informed consent. 6. patients who may need surgery in the near future.

Keywords: cannabis crohn's disease ulcerative colitis ibd
knee extension deficit following an anterior cruciate ligament reconstruction (extension loss)

Conditions: Anterior Cruciate Ligament Injuries

Summary: knee extension loss following an anterior cruciate ligament (acl) reconstruction is believed to play an important role in quadriceps strength recovery. one of the main goals of the rehabilitation following acl reconstruction is to restore knee extensor muscle strength. deficits of more than a five-degree extension range of motion (rom) could lead to delayed knee functionality and anterior knee pain. however, the effect of knee extension deficits in the early postoperative phase of the acl reconstruction on knee extensor muscle strength recovery and knee functionality is not yet known. this study aimed to investigate the difference between knee extensor muscle strength recovery and knee functionality in patients with acl repair who had a knee extension rom deficit (\>5°) in the early postoperative period and those who did not.

knee range of motion deficits are significant surgical complications following an anterior cruciate ligament (acl) reconstruction, and despite current advances in surgical techniques, knee range of motion cannot always be regained. previous studies reported that knee range of motion (rom) deficits play an important role in knee extensor muscle weakness and knee osteoarthritis. thus, deficits in knee extension joint motion are more difficult to tolerate than flexion deficits. it has been reported that a five-degree decrease in the extension rom of the affected knee compared to the healthy side can lead to secondary complications such as difficulty walking and anterior knee pain. however, the effect of knee extension deficits in the early postoperative phase of the acl reconstruction on knee extensor muscle strength recovery and knee functionality is not yet known. this study aimed to investigate the difference between knee extensor muscle strength recovery and knee functionality in patients with acl repair who had a knee extension rom deficit (\>5°) in the early postoperative period and those who did not.

Eligibility criteria:
inclusion criteria: * patients who underwent acl repair using hamstring tendon autograft * volunteered to participate in the study between the ages of 18-45 * a non-contact injury mechanism * a tegner activity score \>5 before the injury * regularly attended the rehabilitation program after surgery (not missing more than three sessions) exclusion criteria: * patients who underwent acl repair with patellar tendon autograft or allograft, revision surgery * underwent meniscus and or cartilage repair in addition to acl repair * a history of previous knee, ankle, or groin injuries * concomitant systemic and/or neurological pathologies * a history of injury to the contralateral lower extremity * do not want to participate in the evaluations that should be done before the study.

Keywords: acl reconstruction knee extension deficit
the recuperation of patients after elective shoulder surgery observational cohort study

Conditions: Aucte Pain After Surgery; Persistent Pain After Surgery; Opioid Use After Surgery; Mode of Anaesthesia

Summary: around 6400 shoulder surgeries are performed yearly in finland. the procedure is mainly day-case surgery and the patients go home in the afternoon. shoulder surgery is one of the most common procedures performed in private surgical practices. because of the complex nature of the joint, the recovery may be complicated by severe opstoperative pain, which is relieved with strong opioids. recently this has been addressed in the literature, as prescribed opioids too often lead to substance abuse. pain in the acute phase after surgery is one of the common risk factors for persistent postoperative pain, which is a major burden for both the individual patient and the society. in this prospective, observational cohort study we aim to describe current standards of practice in planning and taking care of anaeshtesia and prescribing opioids and adjuvants for postoperative pain relief at home.

around 6400 shoulder surgeries are performed yearly in finland. the procedure is mainly day-case surgery and the patients go home in the afternoon. shoulder surgery is one of the most common procedures performed in private surgical practices. because of the complex nature of the joint, the recovery may be complicated by severe opstoperative pain, which is relieved with strong opioids. recently this has been addressed in the literature, as prescribed opioids too often lead to substance abuse. pain in the acute phase after surgery is one of the common risk factors for persistent postoperative pain, which is a major burden for both the individual patient and the society. in this prospective, observational cohort study we aim to describe current standards of practice in planning and taking care of anaeshtesia and prescribing opioids and adjuvants for postoperative pain relief at home. the data is collected prospectively from the care provider and the patient in a webrobol questionnaire at three time points: the day of surgery (care provider), one week after surgery (patient) and three months after surgery (patient).

Eligibility criteria:
inclusion criteria: * 18-85 years * speaks and reads finnish fluently * has access to internet and email * undergoes elective shoulder surgery exclusion criteria: * persistent pain in an area other than the shoulder in question * longterm pain medication for any other purpose than the shoulder in question * schitzophrenia * diabetes mellitus with complications