Kornimate/medical-research-clean huggingface dataset:
the efficacy and security of the small stitch technique in emergency surgery

Conditions: Abdominal Wall Defect; Abdominal Wall Hernia; Eventration; Evisceration; Operation Wound

Summary: this study evaluates the abdominal closure technique in emergency surgery. half of participants will be perform the classic large stitch technique, while the other half will undergo the small stitch technique.

the closure of laparotomy is one of the most important challenges facing the surgeon. the classic technique of wall closure is the large stitch technique that uses monofilament double-strand sutures with a sl/wl (suture lengh/wound lengh) 4:1 ratio, with a distance to the alba line and between each stitch of 1 cm. nowadays, the small stitch technique is accepted as the technique of choice for closure of laparotomies in programmed surgery. it is based on a very long-term monofilament absorbable synthetic suture of poly-4-hydroxybutyrate (monomax) 2/0 with hr (half-circle round body) 26 needle. stitches should be given with a distance to the alba line of 0'5cm and 0'5 cm of separation between stitches. there are very few studies about the role of small stitch technique in the field of emergency surgery where the increased morbidity of the patient and the higher rate of surgical wound infection can play a fundamental role, and could be improved with the use of new abdominal wall closure techniques.

Eligibility criteria:
inclusion criteria: 1. patients over 18 years of age and who provide informed consent to participate in the study. 2. patients requiring an urgent midline laparotomy with a minimum size of 8 cm. exclusion criteria: 1. prior midline laparotomy. 2. patients with bmi\> 45 kg / m2 3. patients with asa (american society of anesthesiologists)\> iv. 4. patient with an advanced terminal illness with an expectation of life \<1 year. 5. patients with abdominal aortic aneurysm. 6. patients with coagulopathy: patient previously diagnosed with von willebrand disease, hemophilia or immune thrombocytopenic purpura. 7. immunosuppressed patient: hiv patients in the aids phase, chronic corticosteroid or immunosuppressive treatment. 8. patients with collagen pathology: patient previously diagnosed with marfan syndrome, ehlers-danlos syndrome, homocystinuria and scleroderma. 9. chemotherapeutic treatment 2 weeks before surgery. 10. radiotherapy treatment 6 weeks before surgery. 11. diffuse peritonitis with hemodynamic instability, defined by non-response to fluids prior to surgery or during the surgical process. 12. pregnant or potentially fertile women, breastfeeding, or intention to become pregnant, or those who do not wish to use effective contraception (hormonal contraceptives (implantation, patches, oral), and double barrier methods (any double combination of: iud (intrauterine device), male or female prophylactics with spermicidal gel, diaphragm, contraceptive sponge, cervical cap).
escitalopram plus ps128 vs. escitalopram

Conditions: Major Depression

Summary: the purpose of this study is to compare the efficacy and safety of escitalopram plus ps128 to escitalopram in the acute treatment of patients with major depressive disorder.

in this 6-week, double-blind, fixed-dose study, patients with major depressive disorder are randomly assigned to escitalopram (10 mg daily) plus ps128 (a psychobiotic) (300 mg two times daily, equivalent to 3 ×1010 cfu two times daily) or escitalopram (10 mg daily) groups. the rating scales and instrument, including clinical global impression-severity, 17-item hamilton rating scale for depression, hamilton anxiety rating scale, global assessment of functioning, heart rate variability, depression and somatic symptoms scale, work and social adjustment scale, short form 36 and pittsburgh sleep quality index, are used to measure treatment outcomes at weeks 0, 1, 2, 3, 4, 5, and 6. uku side effect rating scale and gastrointestinal symptom rating scale-irritable bowel syndrome are used to measure side effects. generalized estimating equations model will be used to analyze the differences between two groups with respect to efficacy and safety measures on time after adjusting for baseline severity, sex, age and age at onset of illness.

Eligibility criteria:
inclusion criteria: * major depressive disorder * cgi \>=4 * the score of the 17-item hamilton rating scale for depression (hamd-17) was 18 or higher. * washout of antipsychotics at least 3 days * written informed consents * not taking fluoxetine at least one month before admission. exclusion criteria: * history of schizophrenia, schizoaffective disorder or organic mental disorders. * comorbid with substance abuse/dependence in the past 6 months. * with psychotic features * treatment-resistant depression or receiving electroconvulsive therapy. * history of serious adverse events to escitalopram * female subjects with pregnancy or lactation. * severe physical illness * receiving antibiotics treatment in the past two weeks. * taking products with probiotics.

Keywords: psychobiotics major depressive disorder escitalopram
impact of personality on adherence to tyrosine kinase inhibitor therapy in pts w/chronic myeloid leukemia

Conditions: Chronic Myeloid Leukemia; Chronic Phase Chronic Myelogenous Leukemia

Summary: this is an observational pilot study to examine the association between a patient's personality and adherence to tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia.

the purpose of this pilot study is to explore the association between personality and adherence to a specific type of oral cancer medication - tyrosine kinase inhibitor (tki) - in patients with chronic myeloid leukemia (cml). 75 individuals with chronic phase cml who are being treated with tkis will be recruited. consenting patients will participate in a focused interview where tki adherence, personality type, and quality of life and symptom burden will be assessed using validated questionnaires. information on treatment response and the treating physician's perception of tki adherence will be obtained from the electronic health record.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * diagnosed with chronic myeloid leukemia (cml) and in the chronic phase (cml-cp) * currently being treated with one of four cancer medications - imatinib, dasatinib, bosutinib, or nilotinib * a patient at the uci chao family comprehensive cancer center (cfccc), or * a member of a patient support group organized by the cml buster foundation * do not meet any of the criteria listed under "exclusion requirements" exclusion criteria: * unable to read and speak english * impaired decisional capacity to consent
near-infrared spectroscopy comparison study

Conditions: Total Aortic Arch Replacement

Summary: the objective of this study is to validate near-infrared (nirs) monitoring in patients undergoing circulatory arrest. this study will compare two-wavelength nirs invos system, somanetics; troy, mi) with four-wavelength nirs (nonin medical, inc; plymouth, mn) to determine which modality best correlates with jugular venous oxygen saturation


Eligibility criteria:
inclusion criteria: 1. provide written informed consent from patient or legally authorized representative before surgery 2. adult patients 18-65 years of age 3. presenting for elective or urgent total aortic arch repair under moderate hypothermic circulatory arrest (nasopharyngeal temperature 20 - 24 ºc) with selective antegrade cerebral perfusion - exclusion criteria: 1. patients will be excluded from this study if they are age less than 18 2. are undergoing an emergent procedure 3. have a history of insulin-dependent diabetes mellitus 4. have a history of stroke 5. are undergoing a redo sternotomy during which major bleeding occurs necessitating transfusion of \> 4 units of packed red blood cells prior to the institution of circulatory arrest 6. patients in whom a left jugular venous bulb cannula cannot successfully be placed

Keywords: near infrared spectroscopy neuromonitoring aortic arch replacement
safety, tolerability, and efficacy of ain457 in patients with uncontrolled asthma

Conditions: Asthma

Summary: this study is a preliminary proof of efficacy study of ain457 in patients with bronchial asthma that is poorly controlled with the current standard of care.


Eligibility criteria:
inclusion criteria: * adult patients with asthma \>1 year duration diagnosed according to the gina guidelines (gina 2010). * daily treatment with \> 1000μg beclomethasone dipropionate or equivalent, plus a long acting beta agonist for ≥ 3 months prior to day 1, that has been stable for at least 4 weeks prior to screening. * asthma which is not adequately controlled on current treatment * peripheral blood eosinophil count \< 400/μl at screening exclusion criteria: * women of child-bearing potential unwilling to use effective contraception during the study and for 16 weeks after stopping treatment. * use of other investigational drugs at the time of screening, or within 30 days of screening. * smokers

Keywords: asthma secukinumab therapeutic uses respiratory lung pulmonary inhaled corticosteroids
efficacy and safety of immersive virtual reality for post-stroke cognitive impairment

Conditions: Stroke; Cognitive Decline

Summary: this is a single-blind randomized controlled trial to evaluate the efficacy and safety of immersive virtual reality for post-stroke cognitive impairment.

this is a single-blind randomized controlled intervention study. each stroke subject will undergo screening period, baseline assessment period, intervention period, endpoint assessment period. in the screening period, the verification of inclusion/exclusion criteria and the acquisition of informed consent will be completed. in the baseline assessment period and endpoint assessment period, cognitive function related scale assessment included mental state examination scale (mmse), montreal cognitive assessment (moca), drawing clock test (dct), shape trials test a.b (stt-a, stt-b), standardized digital modal test (sdmt), auditory verbal learning test-huashan version (avlt-h), and activity of daily living (adl) scale will be used to evaluate the function of each patient. meanwhile, brain functional activation of each patient during the cognitive task (stroop task, 1-back task and verbal fluency test) will be evaluated using functional near-infrared spectroscopy (fnirs). in the intervention period, the vr group will receive immersive vr cognitive training with suitable for training intensity and the control group will receive the conventional cognitive train (occupational therapy) with suitable for training intensity in the control group. the training will lasted 20 minutes per time, 5 times per week for four weeks, with a total of 600 minutes, training frequency will be adjusted according to the patient's own conditions.

Eligibility criteria:
inclusion criteria: 1. diagnosis of stroke by neuroimaging (ct or mri) assessment 2. 18-85 years old 3. be able to follow instructions to complete the test 4. can tolerate the rehabilitation training of this experiment 5. first stroke 6. patients who signed informed consent exclusion criteria: 1. the test could not be tolerated due to organic disease 2. there is a serious mental illness resulting in inability to cooperate with or tolerate this test 3. is participating in another clinical trial involving an investigational drug or physical therapy 4. patients who have not signed informed consent

Keywords: stroke virtual reality fnirs cognitive impairment
prader-willi syndrome macronutrient study

Conditions: Prader Willi Syndrome; Syndromic Obesity; Childhood Obesity

Summary: the overall objective is to explore the mechanisms by which macronutrients regulate food intake and weight gain in prader willi syndrome (pws). previous studies from the investigators' labs suggest that the increased appetite of pws may be triggered or maintained by an increase in the levels of ghrelin, an appetite-stimulating hormone produced primarily by the stomach. this study will compare the effects of low carbohydrate diet versus low fat diet on levels of ghrelin, appetite suppressing hormones and markers of insulin sensitivity in patients with pws. the investigators hypothesize that the low carbohydrate diet will suppress plasma active ghrelin and increase appetite-suppressing hormones to a greater degree and for longer duration than the low fat diet and will thereby reduce hyperphagia and increase satiety. the investigators also hypothesize that the low carb diet will improve hormonal and metabolic markers (fatty acids, amino acids and organic acids) of insulin sensitivity and inflammatory cytokine profiles of children with pws.


Eligibility criteria:
inclusion criteria: * diagnosis of prader willi syndrome confirmed by chromosome analysis (ie. interstitial deletion of paternally-derived chromosome 15q, uniparental maternal disomy or other chromosome 15 abnormalities) * age 5 years to 17 years * written informed consent and assent obtained and willingness to comply with the study schedule and procedures * free t4, tsh values in the normal range (either endogenous or with thyroxine replacement) * weight stable (bmi percentile fluctuation of \<5 percentiles) over the preceding 2 months prior to the study exclusion criteria: * presence of other clinically significant disease that would impact body composition including diabetes mellitus, chronic inflammatory bowel disease, chronic severe liver or kidney disease or neurologic disorders * concomitant use of medications known to affect body weight or investigational drug in the past year

Keywords: prader willi syndrome childhood obesity ghrelin appetite regulation
adiponectin, leptin, h-crp values in obese children - important markers for metabolic syndrome?

Conditions: Obesity, Metabolically Benign

Summary: obesity is a chronic inflammatory disorder in which leptin, adiponectin and c reactive protein (crp) play an important role. this study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive c reactive protein (hscrp) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population

the idea that adipose tissue is just a form of energy storage has changed dramatically in recent years. currently, adipose tissue is considered to be a true endocrine gland that fulfills multiple roles in regulating different biological functions. communication between adipose tissue and the rest of the systems is accomplished through bioactive mediators (adipokines) adipokines control energy homeostasis and are involved in metabolic, endocrine and immunological processes.this study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive c reactive protein (hscrp) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population.the current retrospective observational study was conducted at the "louis turcanu" emergency hospital timisoara over a period of one year, from july 2013 and june 2014. all inborn patient files were analyzed as anonymised limited data sets from archived records of the endocrinology, diabetology and cardiology department.

Eligibility criteria:
inclusion criteria: * obese children (bmi\> 95th percentile) exclusion criteria: * obesity caused by endocrine disease, syndromic obesity, systemic disease or acute illness.

Keywords: adipokines, metabolic syndrome, obese children
respiratory muscle fatigue and lower extremity muscle oxygenation

Conditions: COPD

Summary: in our study, changes in vastus lateralis muscle oxygenation will be evaluated with the moxy device, a functional infrared oxygen measurement device, during the inspiratory muscle fatigue protocol in copd cases and the healthy control group.


Eligibility criteria:
inclusion criteria: * having a diagnosis of stage 2-3 copd according to the following clinical diagnostic criteria according to the american thoracic and european respiratory societies (ats-ers). * having been using the same medications for the last 4 weeks exclusion criteria: * patients with severe comorbid diseases, unstable coronary artery disease, collagen vascular diseases and requiring high-flow oxygen therapy (˃ 3-4 l\\min). * presence of any vascular problem that may affect lower extremity muscle oxygenation * presence of another respiratory system disease other than copd * patients who have had an acute copd exacerbation in the last 4 weeks * patients experiencing copd exacerbations during the study protocol * presence of fatty tissue or scar tissue at the measurement points, which may impair the measurement quality. * have already participated in another clinical trial within the last 30 days that may affect the results of the study. inclusion criteria for healthy cases * being over 18 years of age * not having any diagnosed chronic disease * not being a smoker
social support and reduced fear acquisition

Conditions: Fear; Anxiety

Summary: university of california, los angeles researchers will recruit healthy participants and anxious participants (those diagnosed with social anxiety disorder) age 18-55 years old to participate in a study examining whether the ability of social support figure reminders to prevent the acquisition of fear in healthy participants extends to those with anxiety disorders. after being recruited from the ucla community (healthy participants, n = 50) or referred by treatment providers at the anxiety and depression research center at ucla (anxious participants, n =50) and undergoing a telephone screening and in-person screening, 100 participants will be enrolled in the study. during the experiment, all participants will undergo the same procedures: undergoing fear acquisition procedures--the repeated pairing of a neutral image with a mild electric shock that ultimately leads to the association of threat of shock with the image--in the presence of an image of a social support figure (provided by participants) and an image of a smiling stranger.


Eligibility criteria:
inclusion criteria: * healthy adults 18 and 35 * fluent in english * no history of mental illness (healthy participants: including anxiety, depression, phobia, or any other mental health related disorder diagnosed by a mental health professional) * diagnosis of social anxiety disorder (anxious participants: allowed co-morbid disorders include depression, other anxiety disorders, and ptsd) exclusion criteria: * pregnant or planning to become pregnant during the experiment period * presence of chronic mental illness (healthy participants: as determined by the report of a past diagnosis of mental illness by a physician or psychologist and/or the prescription of medication related to mental health disorder; including anxiety, depression, phobia, or any other diagnosed psychological disorder) * presence of non-allowed co-morbid disorders (anxious participants: including, bipolar disorder, psychosis, substance use disorder, neurological disorder, and/or obsessive-compulsive disorder) * current and regular use of prescription medications related to mental health disorders

Keywords: social support fear acquisition
cardiac biomarker in pediatric heart disease

Conditions: Congenital Heart Disease

Summary: the purpose of this study is to investigate cardiac biomarker during perioperative management in pediatric cardiac surgery.


Eligibility criteria:
inclusion criteria: * children who receive surgery for congenital heart disease * require cardiopulmonary bypass for surgery * under 18 years old exclusion criteria: * simple congenital heart disease (atrial septal defect, ventricle septal defect, patent ductus arteriosus)

Keywords: cardiac biomarker congenital heart disease surgery
gait analysis of ankle arthroplasty and arthrodesis

Conditions: Ankle Arthritis

Summary: surgical options for managing hindfoot arthritis include: joint fusion, total ankle joint replacement or osteotomies (realignment) of bones. fusion of arthritic hindfoot joints has been the accepted method of managing hindfoot arthritis for over a century. recently, total ankle replacement has evolved as a treatment option for patients with end stage ankle arthritis. a comparison of gait for patients before and after hindfoot fusion or total ankle replacement will give further information about the outcome of this treatment. the principal aim of this project is to assess the effect of total ankle replacement or hindfoot fusion on gait. we are also interested in the outcome of the surgery and its effect on your symptoms (eg. pain and mobility). the results of this study will aid researchers in assessing this new treatment modality. your involvement in this study is critical for the researchers to further analyze this new form of treatment and your time and involvement is appreciated.


Eligibility criteria:
inclusion criteria: 1. symptomatic ankle arthritis 2. skeletal maturity 3. able to give informed consent exclusion criteria: 1. avascular necrosis of talus 2. obesity (bmi \>30) 3. prior ankle fusion or arthroplasty 4. active or prior infection within 12 months 5. medical condition precluding major surgery 6. severe ipsilateral mid or hind foot deformity 7. severe osteoporotic or osteopenic bone 8. neuromuscular impairment 9. age less than 40 years old 10. cognitive or psychiatric impairment prohibiting accurate follow-up 11. pregnancy 12. workers compensation board patients
outpatient holmium laser enucleation of the prostate: benefit of moses(tm) 2.0 technology

Conditions: Benign Prostatic Hypertrophy; Holmium Laser Enucleation of the Prostate

Summary: the aim of this study is to compare the success rate of outpatient surgery after holmium laser enucleation of the prostate (holep) for the treatment of bph with and without the use of the moses 2.0 effect.

holep is in the process of becoming the new reference surgical treatment for bph with the main advantages over monopolar transurethral resection (turpm) and high approach adenomectomy (avh): the significant reduction in morbidity perioperative period and therefore the reduction in the length of hospital stay. this reduction in length of stay has led to the development of outpatient care with encouraging results. the main cause of discharge failure on d0 is the persistence of postoperative hematuria requiring maintenance of bladder irrigation. mosestm 2.0 technology has the advantage of better hemostasis compared to the laser lp100 currently used. the objective of this study is to evaluate the influence of mosestm 2.0 technology on the outpatient success rate in patients operated on for holep for bph.

Eligibility criteria:
inclusion criteria: * subject over 50 years old * bph whose symptoms require surgical management * preoperative prostate volume measured by ultrasound (suprapubic or transrectal) ≥ 40g * ipss score \> 15 and quality of life score ≥ 3 * maximum urinary output (qmax) \< 15 ml/sec exclusion criteria: * inability to read or write french * patients with comorbidities contraindicating general anesthesia * patients not eligible for outpatient care according to french recommendations (high risk of complications after general anesthesia, place of residence more than 150 km from an emergency department, alone at home the night following the intervention) . * history of bph surgery * history of prostate cancer * preoperative prostate volume measured by ultrasound (suprapubic or transrectal) \< 40g * existence or history of urethral stricture * existence or suspicion of a "neurological" bladder * positive preoperative cytobacteriological examination not treated appropriately * adult patients subject to a legal protection measure or unable to express their consent * patients deprived of liberty by a judicial or administrative decision or hospitalized without consent or admitted to a health or social establishment for purposes other than research

Keywords: benign prostatic hypertrophy holep moses(tm) 2.0 ambulatory men