Kornimate/medical-research-clean huggingface dataset:
osteoporosis patient education in denmark

Conditions: Osteoporosis

Summary: in an effect evaluation the investigators will examine the effects of participating in osteoporosis patient education. an intervention group who have already participated in patient education will be compared to a matched control group who have not participated. effects on quality of life, fractures, daily functional capacity, self-efficacy, psychological wellbeing, physical function, balance, falls, pain management, and adherence will be examined.

in this quasi-experimental study the investigators will conduct an effect evaluation that compares an intervention group of osteoporosis patients who have participated in patient education in a municipality with a control group who have not participated. the intervention group consists of citizens who have already participated in osteoporosis patient education from 2016 until 2020. the investigators have received information on the intervention group from the municipalities who store data on previous participants. the control group will be extracted via the danish health data authority and consists of citizens who have not participated in osteoporosis patient education. for each individual in the intervention group one control will be matched regarding gender, age, diagnosis, time of diagnose, and type of fracture before the index date (i.e. the date the individual in the intervention group started on patient education). the aim of the effect evaluation is to examine the effects of osteoporosis patient education on quality of life, fractures, daily functional capacity, self-efficacy, psychological wellbeing, physical function, balance, falls, pain management, and adherence. data is generated from a register extraction and a questionnaire-based survey. the questionnaire will include information on quality of life, daily functional capacity, self-efficacy, psychological wellbeing, physical function, balance, falls, and pain management. as far as possible validated questionnaires will be included to measure these outcomes. the register extraction will be made by the danish health data authority and include information on fractures and adherence. all analyses are performed using stata. in the analyses the investigators will compare the intervention group and the control group with regard to all outcomes. the covariates are selected on the basis of directed acyclic graphs (dag) and they include e.g. socioeconomic status, cohabitee status, and co-morbidity. the analysis will be completed on an intention to treat basis.

Eligibility criteria:
inclusion criteria: * to participate in osteoporosis patient education in municipalities the participants should have osteoporosis or in few cases osteopenia. exclusion criteria: * none though this may vary across municipalities

Keywords: patient education
neuro-pain provides a dynamic and interactive register for the invasvive neuromodulatory therapies for different chronic pain syndromes. patients living in belgium and suffering from persistent spinal pain syndromes type 2 as well as suffering from complex regional pain syndromes are included.

Conditions: Chronic Pain Syndromes; CRPS

Summary: patients suffereing from chronic pain due to persistent spinal pain syndromes or complex regional pain syndromes and living in belgium will be included in this register once they are being considered for a treatment with invasive neuromodulation (either spinal cord stimulation either dorsal root ganglion stimulation). the screening process, the multidisciplinary evaluation, the trial therapy and the long-terl follow-up will be monitored through this register.


Eligibility criteria:
inclusion criteria: * chronic pain syndromes exclusion criteria: * acute pain syndromes

Keywords: spinal cord stimulation chronic pain quality of life
impact of two recall intervals on dental caries incidence, anxiety and quality of life of preschool children

Conditions: Dental Caries; Quality of Life; Anxiety

Summary: objectives: to assess the effectiveness of two recall intervals on dental caries incidence (primary outcome) in preschool children with low and moderate caries risk. the level of anxiety, oral health related quality of life (ohrqol), time and cost (secondary outcomes) according to each interval will also be assessed. methods: the sample will consist of 224 children between 3-5 years of age, of both genders, with low and moderate caries risk according to the clinical criteria adapted from the secretary of health of são paulo. children will be randomly allocated into two study groups: group 1 (g1) - oral clinical examination + orientation for oral health and diet on the recall of 12 months; and group 2 (g2) - oral clinical examination + orientation for oral health and diet on the recall of 18 months.

an examiner calibrated and blinded to the study groups and the secondary outcomes will perform the clinical examinations, which consist of: the gingival bleeding index, dental plaque index, detection of caries and its activity according to the icdas (international caries detection and assessment system) and the clinical features of active and inactive caries lesions will be associated with the criteria discribed in icdas commitee manual. an external dentist will conduct the assessment of the anxiety levels assessed by the facial image scale, the ohrqol measured by b-ecohis (brazilian early childhood oral health impact scale), the time and costs. all groups will be followed for a period of 36 months. all analyzes will be performed with the intention of treatment (itt) and considering the sensitivity analyzes to assess the differences between the itt analyzes and the complete cases analyzes.

Eligibility criteria:
inclusion criteria: * children between 3-5 years of age, of both genders, with low and moderate caries risk according to the clinical criteria adapted from the secretary of health of são paulo. * guardians who have signed the informed consent confirming their participation and their child in research. exclusion criteria: * children showing visible dental plaque and gingivitis in baseline. * children showing more than 08 active and/or inactive caries cavitated surfaces, and who show fistula and/or dental abscess. * special patients. * children who received professional application of fluoride in the 6 months prior to the survey.
vcrc tissue repository

Conditions: Aortitis; Cutaneous Vasculitis; Eosinophilic Granulomatosis with Polyangiitis; Giant Cell Arteritis; Granulomatosis with Polyangiitis (Wegener's); Henoch-Schonlein Purpura; IgA Vasculitis; Microscopic Polyangiitis; Polyarteritis Nodosa; Takayasu Arteritis; Churg-Strauss Syndrome

Summary: the purpose of this study is to collect existing tissue specimens from subjects enrolled in vasculitis clinical research consortium (vcrc) studies. analysis of these tissue specimens and linked clinical data collected through vcrc studies may lead to the identification and development of a series of translational research projects. results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.

biopsy specimens collected as standard of care for these diseases will be retrieved and used in research. the most common biopsies performed are kidney, lung, skin, nerves, and vessels; however, other tissue is also of interest for the study. biopsies are not performed as part of this protocol, rather we will request consent to collect biopsy specimens already collected under routine care.

Eligibility criteria:
inclusion criteria: * a participant will be deemed eligible for this study if the participant is/was enrolled in another one of the vcrc observational/longitudinal protocols (5502, 5503, 5504, 5505, 5506, 5507, 5563) and/or one of the vcrc interventional studies (5522, 5523, 5526, 5527, or 5562). exclusion criteria: * inability to give informed consent (or their guardians in the case of children) and to sign the consent form. * unwilling to allow the use of their tissue for research.

Keywords: css egpa gca gpa mpa pan tak hsp
scoring system of structural damage for the hip in juvenile idiopathic arthritis

Conditions: Juvenile Idiopathic Arthritis Hip

Summary: juvenile idiopathic arthritis (jia) is a chronic inflammatory disease in children affecting mobility and physical function. the hip involvement represents a frequent complication in jia patients. the assessment of hip damage becomes a mandatory step in disease monitoring. however, radiological scoring was not standardized. this study aimed to compare the two scoring systems previously proposed, examine their repeatability and their intra and inter agreement.


Eligibility criteria:
inclusion criteria: * all included patient followed the ilar criteria of jia and have a hip involvement. this later was defined as the presence of rang motion limitation, and abnormal findings in pelvic radiographic, or ultrasound or mri in the coxo-femoral joint. exclusion criteria: * the presence of a contraindication to the performance of conventional radiography any disease affecting cognition patients who have had surgery on the hip
ultrasound guided infraclavicular brachial plexus block using levo-bupivacaine alone or combined with dexmedetomidine for hand and forearm surgeries

Conditions: Acquired Deformity of Elbow; Forearm; Hand; Wrist

Summary: to evaluate the efficacy of levo-bupivacaine alone and with dexmedetomidine in ultrasound guided infraclavicular brachial plexus block for hand and forearm surgeries as regard: onset of sensory and motor blockade. duration of sensory and motor blockade. analgesic pain scores using the verbal rating scale (vrs) for pain. duration of analgesia postoperative complications.

technique for ultrasound guided infraclavicular brachial plexus block: preliminary scan * the patient is positioned supine with the arm abducted to 90°(or resting by their side if unable to do so). * the probe is placed immediately medial to the coracoid process in the parasagittal plane. * identify the pectoralis major and minor muscles superficially and the axillary artery and vein(s) deep to this. the vein is usually caudad relative to the artery. * the cords of the brachial plexus are seen as either hypoechoic or hyperechoic structures positioned around the axillary artery. the lateral cord is lateral (cephalad) to the artery, the medial cord medial (caudad),and the posterior cord posterior (deep). they can be difficult to visualize but are usually positioned closely to the artery. ultrasound settings * probe: high-frequency (\>10mhz) linear broadband probe. * settings: mb-resolution/general. * depth: 3-6cm. * orientation: parasagittal. * needle: 50-100mm depending on depth of plexus. technique * an in-plane approach is recommended, inserted from the cephalad end of the transducer. * needle tip visualization may be challenging as the needle angle can be quite steep. * prepare the skin with 0.5% chlorhexidine in 70% alcohol. wait until the skin is dry. * anaesthetize the skin with a subcutaneous injection of 1% lidocaine at the point of needle insertion. * the needle is first advanced posterolateral to the artery to deposit local anesthetic around the posterior cord, 5 o'clock position on artery. * after careful aspiration la is injected in small aliquots, observing the spread of the la which ideally occurs behind and up both sides of the artery forming a 'u' shape around the artery, 1-9 o'clock around the artery. * if medial (caudad) spread is not observed then reinsertion of the needle between the axillary artery and vein, adjacent to the medial cord may be required.

Eligibility criteria:
inclusion criteria: * age: 20-65 years old. * american society of anesthesiologist physical status (asa): i-ii. * operation: forearm \& hand surgeries. exclusion criteria: * patients with chronic pain * those using chronic analgesic medications * history of brachial plexus injury * allergy to the study drugs * hepatic or renal insufficiency or infection at the site of injection
the effectiveness of the screening inventory of psychosocial problems (sipp) in cancer patients

Conditions: Breast Cancer; Lung Cancer; Prostate Cancer; Bladder Cancer; Cervix Cancer; Cancer of Endometrium; Cancer of Skin; Non-Hodgkin Lymphoma; Colorectal Cancer

Summary: the purpose of this study is to evaluate the effectiveness and feasibility of the screening inventory of psychosocial problems (sipp) in consultation settings with respect to early recognition and treatment of psychosocial distress, communication between patients and physicians, and psychological distress and quality of life in cancer patients treated with radiotherapy (rt).

background: the screening inventory of psychosocial problems (sipp) is a short, validated self-administered questionnaire to identify psychosocial problems in cancer patients. the one page 24-item questionnaire assesses physical complaints, psychological complaints, and social and sexual problems. there is very little known about the effectiveness of using the sipp in consultation settings. aim: the aim of this study is to test the hypothesis that using the sipp may prevent underdiagnosis of early symptoms reflecting psychosocial problems, should facilitate communication between physicians and patients about psychosocial distress and may contribute to adequate referral to relevant psychosocial caregivers. methods: a cluster randomized controlled trail (crct) is developed using a solomon four-group design (two intervention and two control groups) to evaluate the effects of using the sipp. radiotherapists instead of patients are at random allocated to experimental or control groups. all included patients are randomized into the groups with and without pre-measurement. psychosocial distress, quality of life, patients' satisfaction about communication with their radiotherapist during first consultation and the number and type of referred patients to psychosocial caregivers are assessed. self-administered assessments are conducted at four times: pre-test before first consultation (t1), and post-tests directly following the first consultation (t2), three months (t3) and one year after (t4) the first measurement. medical information are gathered from patients' medical records. furthermore, a process evaluation is carried out. relevance: using the sipp may lead to a reduction of psychosocial problems and better quality of life, both on the short and long term. if the sipp proves to be effective, the results of this project may contribute to motivate health care workers to use the sipp as a standard method for early detection of psychosocial distress in oncology departments in the netherlands and abroad.

Eligibility criteria:
inclusion criteria: * breast cancer * lung cancer * prostate cancer * bladder cancer * colorectal cancer * cervix cancer * cancer of endometrium * cancer of skin * hodgkin lymphoma * non-hodgkin lymphoma * must receive radiotherapy treatment (rt) * 18 years of age or older exclusion criteria: * metastases * less than 10 fractions of radiotherapy treatment (rt) * unable to read, and speak dutch * unable to complete questionnaires

Keywords: cancer
assessment of a composite prognostic score to predict severe forms of ischemic colitis

Conditions: Ischemic Colitis

Summary: our objective is to determine a prognostic score including ct, clinical and biological criteria predicting the serious (death / surgery) or non-serious (medical treatment) evolution of ischemic colitis and therefore possibly modify the therapeutic management (propose surgical treatment for a severe form based on prognostic score).


Eligibility criteria:
inclusion criteria: * age \> or = at 18 years old; * performing an abdomino-pelvic scan injected within 6 hours of the onset of symptoms; * ischemic colitis proven by endoscopy or surgical data. exclusion criteria: * ct scan performed without injection and / or after 6 hours following the onset of symptoms; * unproven ischemic colitis.

Keywords: ischemic colitis computed tomography
effect of injectable platelet rich fibrin on healing and patient satisfaction following laser gingival depigmentation

Conditions: Gingival Pigmentation

Summary: the objectives of the present study are to: 1. evaluate the effect of i-prf injection following laser gingival depigmentation technique on the healing period as a primary objective. 2. assess patient satisfaction following the procedure in terms of pain and esthetic outcome as a secondary objective.

dental esthetic needs are increasing in recent years with a greater demand on pleasant appearance; including a healthy set of dentitions but also esthetically improved gingival appearance, especially when it is located in the anterior labial region. physiologic gingival hyperpigmentation affects numerous people of different ethnic backgrounds. gingival depigmentation is defined as a periodontal plastic surgical procedure that are aimed at removing the pigmented gingiva and methods aimed at masking the pigmented gingiva. techniques of gingival depigmentation can be classified as; chemical methods mainly by ascorbic acids, surgical methods, electrosurgery, cryosurgery, radiosurgery, and lasers. the study was conducted on eight patients seeking treatment for their gingival hyperpigmentation for esthetic reasons. a total number of 16 sites of facial gingival hyperpigmentation were treated, two in each patient in a split mouth technique. * group i (laser with i-prf): included eight sites that were treated with laser technique for gingival depigmentation, followed by intramucosal field injection of i-prf (as study group). * group ii (laser): included eight sites that were treated with laser technique for gingival depigmentation (as a control group). the clinical outcomes were assessed for each patient: at baseline (pre-operative), post-operative, one week, one month. clinical assessment was done by measuring dopi, clinical wound healing, vas and patient satisfaction questionnaire.

Eligibility criteria:
inclusion criteria: * male and female with age range from 16 to 45 years old. * systemically free from any disease as evidenced by the health questionnaire guided by modified cornell medical index (pendleton et al., 2004). * gingival hyperpigmentation on maxillary and mandibular labial keratinized gingiva score 3 (dummett et al., 1964). * patient with thick gingival phenotype (\>1.5mm) (claffey and shanley, 1986). exclusion criteria * pregnant and lactating women. * smokers. * gingival pigmentation associated with occupational hazards. * patients with missing anterior teeth. * patients with any metallic restoration related to anterior teeth or undergoing orthodontic treatment. * vulnerable groups (prisoners, handicapped and orphans).
a comparative study between ultrasound guided thoracic paravertebral block vs serrartus anterior muscle block in vats as regard their effectiveness in post-operative analgesia

Conditions: Post Operative Pain, Acute

Summary: a comparative study between ultrasound guided thoracic paravertebral block vs ultrasound guided serrartus anterior muscle block in video-assisted thoracoscopic surgeries as regard their effectiveness in post-operative analgesia

the use of loco-regional analgesia is recommended to control postoperative pain after vats as it allows opioid sparing and facilitates early postoperative rehabilitation. different loco-regional analgesic techniques could be used to control pain after thoracic surgery such as a paravertebral block, an intercostal block and serratus plane block. in this study, thoracic paravertebral nerve block will be compared to serratus anterior nerve block, both will be done ultrasound guided (usg) using bupivacaine (0.25%) for postoperative analgesia.

Eligibility criteria:
inclusion criteria: * patients american society of anesthesiologists physical status (asa) i to ii * both sexes. * aged ≥ 20 to ≤ 65years. * scheduled for vats under general anesthesia. exclusion criteria: * patient's refusal. * patients american society of anesthesiologists physical status (asa) iii to iv * patients with major spine deformities. * disruption of the local anatomy, secondary, for instance, to the presence of chest drains or surgical emphysema, resulting in difficulty in ultrasound interpretation and distortion of tissue planes. * patients with bleeding disorders and coagulopathy. * infection at the injection site. * known allergy to local anesthetics. * patients with pre-existing myopathy or neuropathy. * ipsilateral diaphragmatic paresis. * tumors in the paravertebral space at the level of injection.

Keywords: regional anesthesia
effect of extracorporeal shock wave therapy on trapezius muscle stiffness

Conditions: Muscle Stiffness

Summary: this study will examine whether extracorporeal shock wave therapy (eswt) can reduce stiffness in the upper trapezius muscle. muscle stiffness will be measured using a special ultrasound technique called shear-wave elastography (swe), which allows researchers to assess changes in muscle properties. the aim of the study is to better understand if eswt is effective in improving muscle function and reducing discomfort in this region. healthy volunteers will be enrolled, and measurements will be taken before and after the eswt treatment.

this interventional study investigates the acute effects of extracorporeal shock wave therapy (eswt) on the mechanical properties of the upper trapezius muscle, with a specific focus on muscle stiffness. stiffness will be quantified using shear-wave elastography (swe), a non-invasive ultrasound-based imaging modality that allows for real-time assessment of tissue elasticity. participants will undergo baseline swe measurements of the upper trapezius muscle, followed by the application of a standardized eswt protocol. post-treatment measurements will be conducted immediately after the intervention to evaluate acute changes in stiffness. the primary objective is to determine whether a single session of eswt induces measurable changes in muscle mechanical properties. this study will contribute to the growing body of evidence regarding the physiological effects of eswt on skeletal muscle tissue and its potential application in clinical and sports settings. data collected will also support the development of future longitudinal studies assessing the therapeutic relevance of eswt for myofascial dysfunction and musculoskeletal pain syndromes.

Eligibility criteria:
inclusion criteria: * age between 18 and 45 years * healthy individuals with no current musculoskeletal or neurological disorders * no history of neck or shoulder surgery * willingness to abstain from vigorous upper-body exercise 24 hours prior to -measurements exclusion criteria: * presence of neck or shoulder pain within the past 3 months * diagnosed myofascial pain syndrome or fibromyalgia * history of cervical spine injury or neurological conditions affecting upper limbs * use of analgesic or muscle relaxant medication within 48 hours prior to testing * pregnancy * contraindications to eswt (e.g., bleeding disorders, pacemaker, malignancy in treatment area)