Kornimate/medical-research-clean huggingface dataset:
functional performance and biopsychosocial characteristics in individuals with systemic sclerosis

Conditions: Systemic Sclerosis (SSc)

Summary: in individuals with systemic sclerosis (ssc), the loss of functionality severely affects quality of life. this condition may cause psychosocial effects by affecting the person, their family, and the environment. activities of daily living, quality of life, and psychosocial well-being are affected, and aesthetic concerns arise. different scales evaluating the quality of life, functions, and disease characteristics of individuals diagnosed with ssc are accepted. in this field, modified rodnan skin score (mrds), duruöz hand index (dhi), scleroderma health assessment questionnaire (shaq), and short form-36 (sf-36) are frequently used. the bety-biopsychosocial questionnaire is also included in the literature for the evaluation of the biopsychosocial effects of individuals with rheumatism. in addition, it is essential to evaluate the characteristics of individuals who maintain their health with chronic diseases. therefore, assessment parameters such as the chronic disease self-management scale, exercise self-efficacy scale, short form illness perception scale, body awareness questionnaire, central sensitisation scale, and tampa kinesiophobia questionnaire are frequently used in this regard. the 6 minute walk test (6 mwt) is recommended as a frequently used method to determine cardiopulmonary endurance in individuals with ssc. it is known that there is a decrease in the distance walked in this test compared to healthy individuals, and the fall potential of physical performance is an important parameter. in addition, there are also methods used to evaluate physical performance, such as the five-repetition sit-and-stand test (cst), the stair climbing test (sct), and the timed up-and-go test (tug). considering all these effects, there is a need to examine the relationship between functional and biopsychosocial impact in individuals with ssc. this study aims to examine the relationship between functional performance and biopsychosocial characteristics in individuals diagnosed with systemic sclerosis and to present the results for this disease group.


Eligibility criteria:
inclusion criteria: * being diagnosed with systemic sclerosis * to be between 18-65 years old * being reader literate exclusion criteria: * having a severe musculoskeletal disability * being diagnosed with pulmonary hypertension * history of active infection * having a severe neuropsychiatric disorder * pregnancy

Keywords: functionality quality of life biopsychosocial model bety-bq functional performance systemic sclerosis
prospective follow up of minimally invasive chest wall surgery after trauma

Conditions: Rib; Fracture, Multiple, With Flail Chest

Summary: the purpose of this study is to assess the outcome of a muscle sparing, minimally invasive open surgical technique for unstable ribcage injuries after trauma. the investigators will compare the results from the study participants to a historical cohort who were operated with a different surgical technique with large incisions and simultaneous thoracotomy.

this is a prospective follow-up study where the investigators aim to study patients who have undergone surgery with a muscle sparing, minimally invasive technique for unstable ribcage after trauma. the investigators plan on seeing the participants as out patients 6 months and 1 year after surgery. the results will be compared to results from a historical cohort with patients who participated in earlier studies with a different surgical method with large incisions and simultaneous thoracotomy. the investigators plan on including 50 patients since a preliminary analysis has suggested this should be enough to notice statistically significant differences between the groups.

Eligibility criteria:
inclusion criteria: * patients with chest wall trauma who underwent surgical stabilisation for unstable chest wall using a minimally invasive, muscle sparing technique without thoracotomy or thoracoscopy no more than 6 months prior to inclusion. exclusion criteria: * severe head injury (abbreviated injury score (ais) \>3) * spinal injury * neurological or musculoskeletal disease affecting chest wall mobility

Keywords: chest wall trauma minimally invasive surgery muscle sparing
online intervention to prevent perinatal depression and promote breastfeeding

Conditions: Depression; Breastfeeding

Summary: "sunnysideplus" will functionally integrate a web based intervention targeting skills to promote and support breastfeeding, manage mood,and prevent depression. sunnyside plus will build upon the previously tested "sunnyside" intervention which targeted skills to manage mood through an interactive website with didactic material and tools. women in weeks 20-28 of their pregnancy will be randomized to receive either sunnyside plus or sunnyside. the sunnyside intervention will consist of 6 weeks of online lessons during pregnancy and booster sessions at 2 weeks, 4 weeks, and 6 weeks postpartum. sunnyside plus will include additional education and support to improve breastfeeding outcomes. breastfeeding education and skills will be provided during the 6 weeks of online lessons during pregnancy. breastfeeding support will continue through 6 weeks postpartum. this postpartum support will involve weekly online lessons, text support, and video support calls with a lactation educator provided on an as-needed basis. sunnysideplus has the potential to provide a novel paradigm for improving breastfeeding outcomes and preventing depression; one that is accessible, highly scalable and cost-effective.


Eligibility criteria:
inclusion criteria: * female * black or african american * 18 years and older * pregnant and between 20 and 28 weeks gestation * intend to breastfeed their child * have a score of 5-14 on the patient health questionnaire-8 (phq-8) * have access to a broadband internet connection * are able to read and speak english exclusion criteria: * are pregnant with multiples * have visual, hearing, voice, or motor impairment that would prevent completion of study procedures * diagnosed with a major depressive episode, psychotic disorder, bipolar disorder, dissociative disorder, substance use disorder or other diagnosis for which participation in this trial is either inappropriate or dangerous based on self-report * are currently receiving treatment (medication or psychotherapy),have an intention to resume antidepressant medication after delivery (i.e., women who discontinued their medication during pregnancy).
audiological evaluation of anesthetists

Conditions: Hearing Loss

Summary: the investigators aim to investigate the effect of operating room noise on anesthetist hearing


Eligibility criteria:
inclusion criteria: * anesthetist doctor and non-anesthetist doctor less than 40 years exclusion criteria: * doctors above 40 years
immediate effect of plantar vibration on fall risk and postural stability

Conditions: Stroke Patients

Summary: the aim of this study; to determine the immediate effect on fall risk and postural stability of vibration applied to the plantar region in stroke patients.

kırıkkale university faculty of medicine physical therapy will be hospitalized in the usa clinic and volunteers will be involved in stroke rehabilitation. the patients who meet the inclusion criteria and who are excluded from the exclusion criteria will be randomized according to the order of arrival and will be divided into two groups as the vibration group and the placebo group.patients will be taken to the placebo and vibration group respectively in order of arrival. if the next patient falls outside the inclusion criteria of the study, randomization will be applied to the next patient. the vibration group, one session in supine position will be applied to both sides of the soles of the feet under the soles of the feet for 5 minutes with a 15-100 hz frequency ce certified vibration device. in the placebo group, both sides will be held in the supine position under the soles of the foot for 5 minutes each so that the device is in contact with the foot without vibration.

Eligibility criteria:
inclusion criteria: * cognitive and non-communication problems * volunteer to join the work * those with less than 150 kilos * spasticity according to a modified scale ashworth 2 and 3 patients treated with botox * patients at least 8 weeks after stroke diagnosis exclusion criteria: * people who are not stable due to vital signs * open wounds under the soles of the feet * being spastic at the level that will block the base touch * pathological conditions affecting lower limb sense (diabetic peripheral neuropathy, post- fracture surgery) * 20 seconds independent standing * mini mental test score below 24 * multiple sclerosis, parkinson's disease, etc. * those with vision problems * patients with thoracolumbar surgery * patients with spinal canal stenosis

Keywords: stroke vibration fall risk postural stability immediate effect fall risk postural stability
multicenter post-market observational registry of the neochord artificial chordae delivery system

Conditions: Mitral Regurgitation; Mitral Valve Disease; Mitral Valve Insufficiency; Mitral Valve Prolapse; Heart Valve Diseases

Summary: the objective of this study is to evaluate the 5-year outcomes of participants with degenerative mitral valve disease treated with the neochord artificial chordae system, model ds1000 in a post-market setting.

this study is an observational, single-arm, multicenter post-market registry. both prospective and retrospective enrollment will be allowed. no additional invasive or burdensome examinations outside those routinely required for the standard mitral valve repair procedure will be requested.

Eligibility criteria:
inclusion criteria: * has grade iii moderate or grade iv severe degenerative or mixed disease mitral valve regurgitation * study procedure completed after 31 december 2016 exclusion criteria: * heavily calcified valves * valvular retraction with severely reduced mobility * active bacterial endocarditis * complex mechanism of mr (leaflet perforation, etc.) * significant tethering of leaflets * inflammatory valve disease

Keywords: neochord ds1000 artificial chordae mitral valve repair
a pharmacokinetic study of sb-681323 in subjects with coronary heart disease undergoing percutaneous intervention

Conditions: Coronary Heart Disease

Summary: study of sb-681323 (a novel p38 mapkinase inhibitor) in subjects with documented coronary heart disease (chd) undergoing elective percutaneous coronary intervention (pci).


Eligibility criteria:
inclusion criteria: * females must be of non-child-bearing potential. * female subjects must have a negative pregnancy test. * subjects scheduled to undergo elective single vessel pci to be performed within the 6 weeks of diagnostic coronary angiography. * must be on stable dose of statin for = 6 weeks prior to screening, with statin tolerability and ldl \<130 mg/dl (3.4 mmol/l) at screening visit. * must be capable of providing informed consent. * have an hscrp concentration of \>2 mg/l, but \< 10 mg/l at screening. exclusion criteria: * women who are pregnant or breast feeding. * planned pci with multi-vessel stenting. * planned pci with additional revascularization procedures staged at different days during the study period. * planned pci other than stenting (e.g., atherectomy, ptca without stenting, etc). * planned pci of any bypass graft. * history of cabg surgery. * planned cardiac or major non-cardiac surgery within the study period. * disabling stroke in the past 6 months. * history of chronic viral hepatitis or other chronic hepatic disorders. * history of gilbert's syndrome or elevated bilirubin concentrations at screening. * history of increased liver function tests (alt, ast) due to acute or chronic liver conditions, above the upper limit of normal at screening or in the past 6 months. * renal impairment with serum creatinine \>2.0 mg/dl (177umol/l) at screening, or history of kidney transplant, or a history of contrast nephropathy. * current inadequately controlled hypertension (blood pressure \>160 mmhg systolic and/or \>100 mmhg diastolic) on a stable dose of antihypertensive medication. * current poorly controlled diabetes mellitus, defined as hba1c \>10% at screening. * history of severe heart failure defined as nyha class iii or iv or those with known severe lv dysfunction (ef\<30%) regardless of symptomatic status. * history of malignancy within the past 5 years, other than non-melanoma skin cancer. * current life-threatening condition other than vascular disease that may prevent a subject from completing the study. * alcohol or drug abuse within the past 6 months.

Keywords: chd coronary heart disease atherosclerosis inflammation
musical intervention during iv-line placement in neonates

Conditions: Pain

Summary: the goal of this clinical trial is to test the effect of music in reducing the pain felt by newborn children during an intravenous line procedure. an intravenous line is a small tube brought into a vein by using a needle. the main questions it aims to answer are: 1. does playing a lullaby during intravenous line procedures affect the vital signs and behavior of a newborn, compared to not playing music? 2. how do parents and medical staff experience the music that's being played? participants will all receive the same care and treatments as usual. the only difference being about half of the participants will be randomly assigned to the group that gets music. researchers will compare the music group to the non-music group to see if there is any difference in vital signs and behaviors of the child.

after inclusion, a participant will be randomized by drawing a sealed, opaque envelope, the contents of which will be either group a: no music, or group b: music. the outcome assessor will then perform a baseline measurement of vital signs and neonatal infant pain score. then, brahms lullaby will be played from a speaker. when the needle is first introduced into the skin, a second measurement will be performed. for every attempt needed to succesfully place the intravenous line, an additional measurement will be done. finally, after succesful placement of the intravenous line is confirmed by nacl flush, a final measurement will be done. afterwards, a short questionnaire will be filled in by the parents and the medical staffmember(s) that performed the intravenous line. the study groups will be compared to each other in outcome measures, and there will be statistical correction for demographic and clinical confounders, which will be collected from medical files. the research hypothesis is that group b will show a smaller increase in vital signs and nips on average during the procedure, compared to group a.

Eligibility criteria:
inclusion criteria: * connected to a monitor that records vital signs * receives an iv-line exclusion criteria: * has hearing impairment

Keywords: intravenous line newborn music pain management musical therapy
pringle time exceeding 120 min in liver resection

Conditions: Tolerance of the Liver

Summary: intermittent pringle's maneuver is widely used to limit blood loss during hepatectomy, without an established time-limit. however, many authors claims its danger for patients' outcome. the investigators check the short term outcome of a consecutive cohort of patients who underwent hepatectomy with intermittent clamping exceeding 120 minutes.


Eligibility criteria:
inclusion criteria: * patients in whom total cumulative clamping time exceeded 60 minutes. exclusion criteria: * patients in whom total cumulative clamping time was less than 60 minutes

Keywords: liver ischemia; pringle time
pf-06741086 long-term treatment in severe hemophilia

Conditions: Hemophilia A or B

Summary: this study is designed to evaluate the safety, tolerability and efficacy of long-term treatment with pf-06741086 in subjects with severe hemophilia who participated in the 3-month phase 1b/2 b7841002 study. additionally, de novo subjects will be recruited into this study.


Eligibility criteria:
inclusion criteria: * severe hemophilia a or b (factor viii or factor ix activity ≤ 1%) * subjects enrolled as factor viii or factor ix inhibitor patients must have a positive inhibitor test result (above the upper limit of normal) at the local laboratory and must receive a bypass agent as primary treatment for bleeding episodes. * episodic (on-demand) treatment regimen prior to screening * at least 6 acute bleeding episodes during the 6-month period prior to screening exclusion criteria: * known coronary artery, thrombotic, or ischemic disease * concomitant treatment with activated prothrombin complex concentrate

Keywords: hemophilia
atazanavir twice daily

Conditions: HIV Infections; Protease Inhibitor

Summary: the purpose of this clinical research study is to assess the pharmacokinetics of atazanavir administered twice-daily relative to historical data from atazanavir/ritonavir 300/100 mg, given once daily.


Eligibility criteria:
inclusion criteria: * healthy male and female subjects between the ages of 18 to 45 years old with a bmi of 18 to 30 kg/m2
reinnervation of facial muscles after lengthening temporalis myoplasty

Conditions: Facial Paresis

Summary: the purpose of this study is to determine the physiology of nerve healing and the neurotization of the facial muscles after lengthening temporalis myoplasty.

the investigators want to study the physiology of nerve healing after lengthening temporalis myoplasty done for facial nerve impairment. the investigators already observed few cases of spontaneous neurotization and the investigators want to check the nerve command of the facial muscles. clinical and photographic evaluations will be performed before and after a facial nerve block using 1% lidocaine.

Eligibility criteria:
inclusion criteria: * patient who were operated for a facial paralysis by the lengthening temporalis myoplasty procedure in the university hospital of caen and who present signs of contraction of the facial muscles on the plasy side after the procedure. exclusion criteria: * patient with contraindications to the injection of lidocaine * patient treated with beta-blocker * patient on anti-coagulants * pathology cause of facial paralysis evolving * pregnant or lactating * patient incapacitated adult * patient undergoing another study at the same time

Keywords: facial palsy lengthening temporalis myoplasty neurotization of facial muscles
rise with residents

Conditions: Domestic Violence; Child Maltreatment; Pediatric ALL; Psychiatry; Education, Medical, Graduate

Summary: prevention of child maltreatment (cm) remains a public health priority in canada; approximately one-third of canadians report exposure to at least one form of cm. physicians play an important role in recognizing and responding to cm and its associated sequelae. however, increasing evidence indicates that physicians receive insufficient training related to recognizing and responding to cm. cm education is especially pertinent during the pediatric and psychiatry residency period but it remains unclear what the optimal approach is for preparing canadian physicians with the knowledge and skills to effectively recognize and respond to cm. those educational interventions that have been evaluated in medical education contexts have comparatively little emphasis on the complex overlap between ipv, children's exposure to ipv, and other forms of cm. the violence, evidence, guidance, action project (vega) is a novel educational intervention that has the potential to improve the preparation of physicians to be able to effectively recognize and respond to cm in their clinical encounters and takes into account this complex overlap. the purpose of this study is to assess the acceptability and feasibility of a future randomized-controlled trial comparing two approaches to administering the vega intervention, facilitator-led or self-directed vega and whether/how these approaches can support residents' education. the investigators hypothesize that there will be significant increases in preparedness, knowledge and skills, and self-efficacy to recognize and respond to cm in both the experimental and ac arms from time 1 (baseline) to time 2 (immediately after the intervention) and time 1 (baseline) to time 3 (3 month follow-up). the investigators also predict that these improvements will be slightly attenuated in the experimental arm. qualitative data pertaining to perceived value and impact will corroborate the quantitative findings.


Eligibility criteria:
inclusion criteria: * participant is a resident at a canadian university. * participant is fluent in written and spoken english. exclusion criteria: * participant has previously accessed vega intervention materials. * participant is currently enrolled in or plans to enroll in any other educational intervention focused on family violence within the study time period (approximately next 3 months).

Keywords: family violence medical education education scholarship health professions education mandatory reporting child maltreatment
assessement of the knoweldge ,attitudes,practices of diabetic kidney disease among diabetic patients

Conditions: Diabetic Nephropathy

Summary: this research aims to evaluate the levels of knowledge , attitudes and practices, of diabetic kidney disease among diabetic patients.

diabetic kidney disease is defined as patients with diabetes mellitus who have persistent proteinuria for at least three consecutive measurements per year, or a decrease in gfr (\<90 ml/min/1.73m²) .diabetic kidney disease is a severe microvascular complication frequently associated with both type 1 and type 2 diabetes mellitus, is a leading cause of renal failure. the condition can also lead to accelerated cardiovascular disease and macrovascular complications. in egypt, dm is a dilemma and a fast-expanding concern. according to the international diabetes federation (idf), the prevalence of dm among egyptian adults is 15.2%, which may be an underestimation.public awareness, knowledge, and preventive practices are crucial in mitigating the onset and progression of diabetic nephropathy. gaining insights into the general population's awareness, knowledge, attitudes, and practices (a-kap) pertaining to this condition is crucial for the development of effective educational campaigns and preventative strategies.

Eligibility criteria:
inclusion criteria: * • diabetic patients (either type 1or 2 dm ) with age above 18yrs old. exclusion criteria: * • ckd patients due to cause other than diabetes. * patients who refuse participation in the study.
study to evaluate drug-drug interaction between valopicitabine and ribavirin

Conditions: Chronic Hepatitis C

Summary: this study is being conducted to see if the investigational medication, valopicitabine, is safe to use in combination with ribavirin, a drug approved by the fda for treating hepatitis c infection.


Eligibility criteria:
inclusion criteria: * documented clinical history compatible with chronic hepatitis c and compensated liver disease * has not previously received anti-viral therapy for hepatitis c infection other protocol-defined inclusion criteria may apply. exclusion criteria: * patient is pregnant or breastfeeding * patient is co-infected with hepatitis b virus and/or hiv other protocol-defined exclusion criteria may apply.

Keywords: treatment-naive