resveratrol and first-degree relatives of type 2 diabetic patients

Conditions: Pre-diabetes

Summary: the main objective of the study is to investigate if resveratrol supplementation can improve overall and muscle-specific insulin sensitivity in first-degree relatives of type 2 diabetic patients. as a secondary objective the investigators want to investigate whether the improved insulin sensitivity can be attributed to improved muscle mitochondrial oxidative capacity and a reduced intrahepatic and cardiac lipid content. furthermore, in a subset of the participants the investigators want to investigate the effect of resveratrol on glucose uptake in brown adipose tissue.


Eligibility criteria:
inclusion criteria: * male sex * age: 40-70 years * bmi 27-35 kg/m2 * has first-degree relative(s) diagnosed with type 2 diabetes * sedentary * not more than 2 hours of sports a week * no active job that requires strenuous physical activity * stable dietary habits: no weight gain or loss \> 5kg in the last three months * insulin resistant: glucose clearance rate below \< 350 ml/kg/min, as determined using ogis120 * willingness to abstain from resveratrol-containing food products * subjects will only be included when the dependent medical doctor of this study approves participation after evaluating data obtained during screening exclusion criteria: * use of anticoagulants * uncontrolled hypertension * haemoglobin \<7.8 mmol/l * in case of an abnormal ecg in rest: this will be discussed with the responsible medical doctor * hba1c \> 6.5% * diagnosed with type 2 diabetes * medication use known to interfere with glucose homeostasis/metabolism * current alcohol consumption \> 20 grams/day * subjects who don't want to be informed about unexpected medical findings during the screening /study, or do not wish that their physician is informed, cannot participate in the study. * subjects who intend to donate blood during the intervention or subjects who have donated blood less than three months before the start of the intervention. * participation in another biomedical study within 1 month before the first screening visit * any condition, disease or abnormal laboratory test result that, in the opinion of the investigator, would interfere with the study outcome, affect trial participation or put the subject at undue risk * any contra-indication to mri scanning. these contra-indications include patients with following devices: * central nervous system aneurysm clip * implanted neural stimulator * implanted cardiac pacemaker of defibrillator * cochlear implant * insulin pump * metal containing corpora aliena in the eye or brains

Keywords: resveratrol diabetes mellitus diabetes mellitus, type 2 insulin resistance glucose metabolism disorders metabolic diseases endocrine system diseases hyperinsulinism anti-inflammatory agents, non-steroidal analgesics, non-narcotic analgesics sensory system agents peripheral nervous system agents physiological effects of drugs pharmacologic actions anti-inflammatory agents therapeutic uses antirheumatic agents antineoplastic agents, phytogenic antineoplastic agents antioxidants molecular mechanisms of pharmacological action protective agents enzyme inhibitors platelet aggregation inhibitors hematologic agents antimutagenic agents anticarcinogenic agents central nervous system agents brown adipose tissue