Kornimate/medical-research-clean huggingface dataset:
fitness, physical activity and movement analysis in obese patients undergoing bariatric surgery

Conditions: Sleeve Gastrectomy

Summary: this study aims to describe the effects of sleeve gastrectomy, the most commonly performed bariatric procedure worldwide, on functional capacity, habitual physical activity, physical fitness (cardiorespiratory and muscular fitness) and gait parameters in severely obese subjects undergoing bariatric surgery. functional capacity, physical activity, physical fitness and gait parameters will be objectively assessed and compared among candidates seeking sleeve gastrectomy and 6 months after sleeve gastrectomy.

this study is a monocentric longitudinal study conducting in obese patients: candidates to sleeve gastrectomy and these same patients 6 months after.the primary aim of this study is to describe the effects of sleeve gastrectomy on habitual physical activity, physical fitness (cardiorespiratory and muscular fitness) and gait parameters in severely obese patients. functional capacity will be assessed during a 6-min walk test, habitual physical activity with accelerometers during 7-day recordings in habitual life conditions (actigraph gt3x® and activpal®), cardiorespiratory fitness during a maximal exercise test on a cycle ergometer with a direct measure of peakvo2, muscle strength with an isokinetic dynamometer (contrex®), muscle power and postural stability with force platforms (kistler® and satel®) and gait parameters with a gait analysis system (gaitrite®). fatigue, quality of life and joint pain will be assessed with questionnaires (mfi-20, sf36 and womac, respectively).

Eligibility criteria:
inclusion criteria: * female gender * age between 18 and 65 years * planned obesity treatment by sleeve gastrectomy * patient with massive obesity (bmi ≥ 40 kg/m2) or severe obesity (bmi between 35 and 40 kg/m2) with comorbidities * written informed consent exclusion criteria: * subject not affiliated with a social security scheme * regular follow-up not feasible * participation in a structured physical activity program * severe orthopedic problems * disabling neuropathy * recent (\< 6 months) coronary event * abnormal cardiac stress test * pregnancy

Keywords: obesity bariatric surgery sleeve gastrectomy physical activity movement analysis
knotless implants as an alternative for capsular closure in primary hip arthroscopy: a prospective, multi-center study

Conditions: Femoro Acetabular Impingement

Summary: the purpose of this research is to see if the arthrex looploctm device is better for capsular closure during hip arthroscopy than other treatments available. the hip capsule is the tissue that surrounds your hip joint. it stabilizes and supports your hip joint. during hip arthroscopy, this tissue must be cut through in order to perform the hip arthroscopy. once the hip arthroscopy is completed, the surgeon might repair the capsule. current ways of repairing the capsule include knotted suture that might irritate structures around the hip, leading to the possible formation of scar tissue and pain. the arthrex looploctm device is knotless and may lower the presence of irritation and scar tissue around the hip after surgery and might lead to better outcomes. therefore, researchers will compare patients who had the looploctm device used to close their hip capsule during surgery to those who did not have the device used, to see if there is a difference in their outcomes following surgery.

the purpose of the study is to perform a prospective multi-center study evaluating the feasibility of a knotless capsular closure device in patients undergoing primary hip arthroscopy. all patients that meet study inclusion and exclusion criteria will then be informed about the study and given the irb-approved consent form. all patients will learn about the study during a clinic visit and will have the opportunity to review the consent form and ask questions. all questions and concerns about study participation and the consent form will be addressed by staff and staff will ensure patient understanding of the consent form. the study participant will then sign and date the consent form, as well as the research staff obtaining consent. consent can be withdrawn at any time the participant chooses either verbally or in writing. patients will be indicated by their physician for a capsular closuring using the looploctm device. these patients will follow up for two years with their providers and researchers, who will collect their patient-reported and clinical outcomes. data from this study will be analyzed to determine if the looploctm device for capsular closure has better outcomes than the alternative treatments available.

Eligibility criteria:
inclusion criteria: * patients undergoing a primary hip arthroscopy * patients younger than 60 years old. * patients who will receive capsular closure with the arthrex looploctm device following hip arthroscopy. exclusion criteria: * patients that had previous hip surgery, * patients that had a center edge angle (cea) less than 25 degrees or greater than 40 degrees. * patients that have a cartilage damage grade greater than or equal to 3.

Keywords: hip arthroscopy hip capsule
vascular amputee physical performance qualitative (vampp-q) study

Conditions: Vascular Disease, Peripheral; Amputation; Physical Disability

Summary: background: peripheral arterial disease (pad) is the main cause of amputation to the lower limb within the uk, affecting over 20% of adults older than 70 years. after an amputation, individuals often use a wheelchair and do not walk with a prosthetic limb. this is due to them experiencing: older age, muscle weakness, pain, other health conditions limiting ability to exercise eg. heart problems. healthcare professionals assess physical function with physical performance based outcome measures (perboms). a perbom requires an individual to complete tasks that are part of their day to day life e.g. walking or balance. perboms are used with for: * setting goals with patients * assessing how patients respond to treatment/rehabilitation * predicting if patients are likely to use a prosthetic limb in the future previous research shows most of the available perboms are suitable an amputee who walks with a prosthetic limb. however, most vascular amputee patients cannot benefit from these assessments. therefore, based on this evidence we have developed a new perbom to help manage vascular amputees who do not walk with a prosthetic limb. methods: qualitative interviews and focus groups with amputee individuals and healthcare professionals who treat them. approaching individuals who have or will undergo an amputation to their leg due to pad. approaching healthcare professionals through professional networks. interviews and focus groups will take place face to face or remotely by telephone/video conferencing, lasting approximately 1-2 hrs. in the interview or focus group, the researcher will explain and show individuals a video of the new perbom and explore their opinions qualitatively on this new perbom. all audio will be recorded, written up and analysed. all findings will be presented at scientific conferences. this study has been developed with patients and public involvement.


Eligibility criteria:
vascular amputee group: inclusion criteria * undergone major lower limb amputation due to peripheral arterial disease and/or diabetes at any time point * or * planned date for major lower limb amputation within 1 week of consent due to peripheral arterial disease and/or diabetes exclusion criteria * has/will undergo a minor amputation only * amputation due to alternative aetiology * no plan for amputation to lower limb * unable to communicate or write in english * lacking capacity to consent to research study * \>1 weeks or unspecified date for amputation surgery * \<18 years healthcare professional group: inclusion criteria • healthcare professional currently working with vascular amputees. healthcare professional defined as qualified professional background e.g. hcpc, nmc or gmc registered or non-qualified professional background e.g. healthcare support worker exclusion criteria * no experience of working with vascular amputee patients * unable to speak or write english
a chatbot intervention for reducing hpv vaccine hesitancy

Conditions: Cervical Cancer; Anal Cancer; Penile Cancer

Summary: the goal of this project is to test the efficacy of a chatbot intervention for reducing hpv vaccine hesitancy among african american parents. an online experiment will be conducted to test the effectiveness of the chatbot intervention with african american parents. results of this project will inform future communication interventions for reducing vaccine hesitancy among african american parents.

the goal of this project is to test the efficacy of a chatbot intervention for reducing hpv vaccine hesitancy among african american parents. an online survey-experiment will be conducted. in the survey-experiment, participants will first answer questions related to their attitudes toward childhood vaccines and see a brief cdc message about hpv vaccine. then they will be directed to interact with a chatbot designed to deliver personalized hpv vaccine messages (tailored to the participant's personality) or a similar chatbot with non-personalized messages. there will also be a control condition where participants will see the brief cdc message about hpv vaccine but will not interact with any chatbot. all participants will answer questions related to their attitudes toward hpv vaccination, intentions to vaccinate their children, as well as other message response measures.

Eligibility criteria:
inclusion criteria: * 18 years or older * self-identify as black or african american * parents of children under 18 years old * access to computer/laptop/mobile device and the internet exclusion criteria: * under 18 years * does not self-identify as black or african american * not a parent of at least a child under 18 years old * no access to computer/laptop/mobile device or the internet
neck anatomy and phrenic nerve palsy after bpb

Conditions: Diaphragm; Paralysis

Summary: the purpose of this study was to determine the association between the anatomical characteristics of neck and postoperative diaphragmatic paralysis in patients undergoing interscalene brachial plexus block before shoulder arthroscopic surgery.

the purpose of this study was to determine the association between the anatomical characteristics of neck and postoperative diaphragmatic paralysis in patients undergoing interscalene brachial plexus block before shoulder arthroscopic surgery. in addition, we want to identify risk factors for diaphragmatic paralysis after brachial plexus block. through this study, we can find the basis for predicting the possibility of diaphragmatic paralysis after brachial plexus block according to the patient's anatomical characteristics and procedural factors.

Eligibility criteria:
inclusion criteria: * adult patients over 19 years undergoing shoulder arthroscopic surgery for a rotator cuff tear repair under general anesthesia exclusion criteria: * patients who refused to participate in the trial * patients with respiratory diseases such as asthma and chronic obstructive pulmonary disease * patients with neurological abnormalities of the upper limb * patients with a history of surgery around the neck on the ipsilateral side of the surgery site, radiation treatment history, etc. * patients with a history of allergy or hypersensitivity reactions to local anesthetics
impact of three continuing education meetings for community pharmacists on weight management

Conditions: Continuing Pharmacy Education; Obesity

Summary: this study is a three-arm randomized controlled trial to evaluate the effects of 1-day continuing educational meetings for community pharmacists with three distinct educational methods: 1) didactic lecture 2) didactic lecture plus case discussion in a large group 3) didactic lecture plus small group education with simulated patient knowledge and attitude of the participants would be measured as the study outcome in three periods: pre-education, post-education and 1 month after the meetings.

the study is designed as an instructor blinded-randomized controlled trial. an educational need assessment is undergone prior to educational content preparation by interviewing 5 community pharmacists. after educational content preparation by instructors, the outcome assessment tool (knowledge, attitude questionnaire) would be designed by a distinct investigator. closed and open-ended questions are included to investigate different levels of bloom's taxonomy. the questionnaire would be validated by specialists other than the instructors and it will piloted to investigate the reliability( cronbach's alfa \> 0.7). community pharmacists of tehran,capital city of iran, would be invited to participate in the study. the participants would be randomly assigned to 3 groups by random number table. each group receives the same education content with a different method: 1. didactic lecture 2. didactic lecture plus case discussion in a large group 3. didactic lecture plus small group education with simulated patient(sp). interviewing with sp is conducted by small group facilitators with brain storming technic. each participant receives a compact disk which includes the educational material and he/she would be able to contact the instructors by phone or e-mail during the follow-up period. (reinforcement phase)

Eligibility criteria:
inclusion criteria: * community pharmacist exclusion criteria: * less than four hours of daily work in community pharmacy
efficacy of cyclic dsg compared with cyclic mpa for the treatment of anovulatory dub

Conditions: Dysfunctional Uterine Bleeding

Summary: the objectives of the present study is to determine the effectiveness of cyclic desogestrel (dsg) compared with cyclic medroxyprogesterone acetate for the treatment of anovulatory dysfunctional uterine bleeding (dub) in the following aspects: 1. endometrial histopathology changes 2. menstrual cycle control.

anovulatory dysfunctional uterine bleeding (dub) is the most common cause of abnormal uterine bleeding especially in postmenarcheal adolescent, perimenopausal women, patient with polycystic ovary syndrome (pcos) and in obese women. aims of treatment in women with anovulatory dub are to restore the natural control mechanism of endometrium (introduce normal synchronous growth, development, shedding of a structural stable endometrium) and to prevent endometrial hyperplasia. the two main treatment options are estrogen-progestin therapy and progestin therapy. women who are sexually active and not immediately prepared to pursue pregnancy are best manage by estrogen-progestin treatment especially combined oral contraceptive pills (cocs) but in perimenopausal women, obese women or women who can't tolerate cocs or have contraindications in using cocs, cyclic progestin will be the treatment of choice. common used progestin in anovulatory dub is medroxyprogesterone acetate (mpa) 5-10 mg/day for 10-14 days each month. this progestin has strong progestogenic effect but has some undesirable effect such as glucocorticoid effect, mineralocorticoid effect and androgenic effect. long term using this progestin especially in obese women or perimenopausal women who have risk for diabetes mellitus and dyslipidemia may be negative effect to glucose and lipid metabolism. dsg is the third generation progestin with no glucocorticoid, mineralocorticoid effect and low androgenic effect may be the better choice of treatment but the data of dsg in treatment of anovulatory dub us scanty. so this study will evaluate the effect of cyclic dsg in endometrial histology changing and lipid, glucose metabolism in patient with anovulatory dub. comparison : women with anovulatory dub are randomized into two groups, receiving a course of either cyclic dsg or cyclic mpa. the main outcome measured is to compare the effect of both interventions on endometrial histology changing.

Eligibility criteria:
inclusion criteria: * premenopausal women with anovular dub (proved by endometrial histology) * age \> 18 yr. exclusion criteria: * any uterine pathology that might cause abnormal uterine bleeding * contraindication to progestin treatment (such as breast cancer) * severe drug allergy towards a progestogen * intake of any hormonal treatment in the previous 3 months

Keywords: anovulatory dysfunctional uterine bleeding cyclic desogestrel cyclic medroxyprogesterone acetate lipid metabolism glucose metabolism endometrial histology changing
evaluation of four injectable neuromodulators in the glabella area glabella area

Conditions: Cosmetic Techniques

Summary: the purpose of the study is to use 3d imaging to evaluate the effects of four fda approved neuromodulators on facial lines, wrinkles and animation. participation is available to women who have never had a cosmetic procedure above the malar region nor a treatment with a neuromodulator within 12 months. all subjects will undergo 3d imaging using the vectra m3 (canfield scientific, inc, fairfield, nj) prior to treatment with a neuromodulator in order to determine their baseline dimensions. imaging will be repeated post injection to determine change over time.

this study is a randomized controlled trial in which patients will be randomly assigned into one of four groups: those receiving onabotulinumtoxina (botox, allergan, irvine, california), abobotulinumtoxina (dysport, ispen biopharmacueticals inc.cambridge, ma), incobotulinumtoxina (xeomin, raleigh, nc) or prabotulinumtoxina (jeuveau, evolus, newport beach, california). each patient will receive fda approved dosages in which they are assigned in to treat rhytids within the glabella, as per fda approved indications. all injections will be performed by a blinded single trained physician according to a preset injection plan per fda approved administration guidelines. prior to injection patients will be imaged with 3-dimensional photogrammetry. all pre-procedure images will be evaluated for absolute strain performing two types of facial animation: 1) relaxed, and 2) frowning. subjects will return day 3, 30, 90, and 180, post intervention for re-imaging with the same expressions. strain will be calculated using the same metrics.

Eligibility criteria:
inclusion criteria: * female * 30-65 years of age * interested in glabellar injections to reduce rhytids and facial strain * participants must sign the informed consent form exclusion criteria: * females under 30 or above 65 years of age * males * those who have received glabellar injections for rhytids \<12 months * underwent cosmetic surgical procedure above the malar region * those with a condition that affects facial expression, such as prior stroke

Keywords: minimally invasive procedures neurotoxins cosmetic botox eyebrow area glabella dysport jeuveau xeomin forehead cosmetic injections facial rejuvenation wrinkle reduction
anergia-anhedonia by lithium-induced phosphorus diabetes

Conditions: Mood Disorders

Summary: lithium (li+) is prescribed to 1‰ of the french population (\~ 60,000 patients). more than half of patients describe subjective symptoms linked to li+ (ssl) similar to those of chronic fatigue syndrome: muscle weakness, fatigability, cognitive disorders, emotional blunting. ssl are the 2nd cause of stopping li+ (28%), just behind kidney problems (30%). in animals, the administration of lithium (li+) increases the urinary excretion of phosphate (pi) by 6, inducing phosphate diabetes (dpi). however, idiopathic forms of dpi explain up to 10-15% of chronic fatigue syndromes and these disappear when supplementing with pi (± vitamin d). in humans, the introduction of li+ leads to a reduction in serum phosphate but we have not found any publication on the possible induction of dpi or on a possible link between dpi and ssl. however, the dosages necessary to detect a dpi are carried out during the annual follow-up assessment of patients on li+. all you have to do is calculate the standardized maximum reabsorption rate of pi (tmpi) to make the diagnosis! finally, if the patients presenting with dpi turn out to be the same as those who complain of ssl, we can imagine that correcting the first by simple supplementation with pi (± vitamin d) could provide relief.

the aim of the study is to determine the prevalence of hypophosphatemia, dpi and ssl in a population of ambulatory patients controlled on li+ (\> 6 months).

Eligibility criteria:
inclusion criteria: * major subject (≥ 18 years old) * man or woman * subject balanced on li+ (\> 6 months, regardless of the underlying pathology). * outpatient monitoring by one of the members of cedra (alsace expert center for resistant depression). * subject not opposing, after information, the reuse of their data for the purposes of this research exclusion criteria: * subject having expressed opposition to participating in the study * subject under judicial protection * subject under guardianship or curatorship

Keywords: diabetes, phosphate anergia-anhedonia lithium (li+) mood disorders
memory encoding strategies for people with mild cognitive impairments

Conditions: Mild Cognitive Impairment; Mild Dementia

Summary: the purposes of the study are: * to evaluate the effectiveness of a perceptual-based training program in enhancing cognitive and everyday functioning of older adults with mild cognitive impairment and mild dementia * to evaluate the effectiveness of a semantic-based training program in enhancing cognitive and everyday functioning of older adults with mild cognitive impairment and mild dementia

people with dementia experience a cognitive decline that affects their functional performance. it has been identified that encoding is less effective in people with dementia. rehabilitating at the encoding stage is, therefore, essential. a recent systematic review found that effective interventions needed to include training in individually selected memory encoding strategies. these strategies are classified as either perceptual (visual) or semantic (association) memory encoding strategies. based on the above literature, the chief investigator (associate professor karen liu) ran a pilot study on an integrated home and community centre cognitive training programme for 20 elderly people with memory problem using a pre-test and post-test comparison design. extending on the positive results, the aim of this project was to investigate the effectiveness of perceptual and semantic encoding strategies (and compare with a control intervention). it also aims to promote the understanding of memory loss and dementia and the need for early intervention for family members of the participants.

Eligibility criteria:
selection criteria: * are aged 60 or above; * have no previous psychiatric or memory disorder history or other neurological illness; * have mini-mental state examination score (mmse) greater than or equal to 21; * have clinical dementia rating score (cdr) of 0.5 or 1 indicating very mild and mild dementia; * do not show sign of depression with score below 9 out of 30 in the geriatric depression scale; * are able to communicate effectively; * have family member who can participate in the study; and * voluntarily consent to participate in the study.