Kornimate/medical-research-clean huggingface dataset:
a study to evaluate the safety, tolerability, pharmacokinetics (pk), and immunogenicity of apg777 in adults with asthma

Conditions: Asthma

Summary: this is a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pk, and immunogenicity of apg777 in adult participants with mild-to-moderate asthma. the duration of the study will be approximately 52 weeks (364 days) for each participant and will consist of a screening period, treatment period, and follow-up period.


Eligibility criteria:
inclusion criteria: * have a diagnosis of mild-to-moderate asthma (global initiative for asthma 2023 criteria) ≥ 1 year prior to screening * maintain feno-high (≥ 25 parts per billion \[ppb\]) or feno-low (\< 25 ppb) status from screening to day 1 prior to randomization * pre-bronchodilator forced expiratory volume in 1 second (fev1) ≥ 60% of predicted normal value at screening * asthma control test (act) score \> 19 at screening * maintained control on as-needed short-acting beta-agonist (saba) +/- stable dose inhaled corticosteroids (ics) or stable dose of ics/ long-acting beta-agonist (laba); +/- stable dose leukotriene receptor antagonist (ltra). ics dose should be stable for ≥ 12 weeks prior to day 1, ltra dose should be stable for ≥ 8 weeks prior to day 1 * women of childbearing potential and male participants to use a highly effective form of contraception exclusion criteria: * any asthma exacerbation requiring systemic corticosteroids within 12 weeks of screening and/or any asthma exacerbation that resulted in overnight hospitalization within 6 months prior to screening * any history of life-threatening asthma, defined as an asthma episode that required intubation and/or was associated with hypercapnia * history of biologics use for treatment or control of asthma * current smokers or participants with a smoking history of ≥ 10 pack years * known history of illicit drug abuse, harmful alcohol use note: other protocol defined criteria may apply.

Keywords: asthma mild to moderate asthma tolerability immunogenicity pharmacokinetics
incidence of postoperative ketosis and metabolic acidosis

Conditions: Metabolic Acidosis

Summary: the aim of this study is to define the incidence and nature of acidosis after major surgery using figge's equations to directly measure acidosis. this study will also aim to compare the ability of indirect measures (base deficit, anion gap,corrected anion gap and lactate) to identify the presence of tissue acids in this population. the incidence of postoperative ketoacidosis as a contributor to tissue acidosis will be assessed through the use of point of care urinalysis.

metabolic acidosis is a frequent occurrence following major surgery. monitoring acid base disturbances and in particular diagnosing the aetiology of the acidosis are important parts of assessing a patient's cardiovascular status following surgery. the presence of a metabolic acidosis is frequently attributed to anaerobic metabolism leading to the generation of lactic acid due to hypovolaemia and poor tissue perfusion. this commonly results in clinicians treating postoperative patients with a metabolic acidosis by administering intravenous fluids containing 0.9% saline or hartmann's solution (compound sodium lactate). if the cause of the metabolic acidosis is not hypovolaemia, treatment with intravenous fluids may actually exacerbate the acidosis by causing hyperchloraemia. an often overlooked cause of metabolic acidosis after surgery is starvation leading to ketoacidosis. all patients are starved for a minimum of six hours prior to general anaesthesia due to the potential risk of aspiration of gastric contents into the bronchial tree. many patients are in fact fasted for much longer periods than this. there is, however, little data describing the incidence of ketoacidosis following surgery. in addition, there may be other causes of acidosis after surgery which often overlooked but can be determined using equations and mathematical models. the aim of this study is to define the incidence and nature of acidosis after major cancer surgery using using equations to directly determine acids. this study will also aim to compare the ability of commonly used indirect measures (base deficit, anion gap, corrected anion gap and lactate) to identify the presence of tissue acids in this population. the incidence of postoperative ketoacidosis as a contributor to tissue acidosis will be assessed through the use of point of care urinalysis.

Eligibility criteria:
inclusion criteria: * patients who have undergone major cancer surgery * patients who have an arterial line in place * patients who have a urinary catheter in place * patients who will be admitted to intensive care following surgery * adults \>18 years * adults who are capable of reading and understanding english exclusion criteria: * patient refusal * patients without an arterial line or urinary catheter in place * patients receiving glucose / sliding scale insulin for management of diabetes mellitus

Keywords: cancer metabolic acidosis
pathways, a hope intervention to support personal goal pursuit, mental health, and quality of life during advanced lung cancer treatment

Conditions: Lung Cancer

Summary: this study will compare the effects of a brief supportive intervention, called pathways, against enhanced usual care on the mental health and quality of life of people undergoing treatment for advanced lung cancer. patients will complete baseline survey measures and be randomized to intervention. survey measures will be collected again mid-intervention, post-intervention and at 6- and 12-week follow-up, with analyses focused on changes pre- to post-intervention.


Eligibility criteria:
inclusion criteria: * new or recurrent ajcc 8th edition stage 3b, 3c, or iv non-small cell lung cancer, extensive stage small cell lung cancer * 18 years of age or older * eastern cooperative oncology group (ecog) performance status 0-2/karnofsky 60-100 * 3-12 weeks into systemic, infusion-based treatment (chemotherapy, immunotherapy, chemo-immunotherapy) * past month distress score (per electronic health record) of 3/10 or higher or a rotterdam symptom item score of 2 or higher for psychological distress items. exclusion criteria: * unstable brain metastases (i.e., progressive neurological deficits, inadequately controlled seizures, or requiring escalated steroid doses) * cognitive (i.e., dementia) or psychiatric condition (e.g., psychotic disorder) for which participating would be inappropriate * receiving overlapping palliative care or psychological services at the cancer center * unable to speak and read english. * hearing or visual impairment that precludes study participation

Keywords: advanced cancer palliative supportive oncology psychosocial intervention
the effect of ethinyl estradiol on polycystic ovary syndrome women undergoing intrauterine insemination

Conditions: Infertility

Summary: according to the studies cc is successful at inducing ovulation in 50%-75% of cases, but only 30-40% becomes pregnant. the difference has been attributed to a negative action of clomifen citrate(cc) in the form of prolonged antiestrogenic effects on endometrial receptivity. for avoiding of these negative effects, giving ethinyl estradiol in sufficient dosages may be effective. the purpose of this study is comparing pregnancy rates after iui in women who use cc alone and those who use cc in combination with ethinyl estradiol

the proposal of this study approved by our institutional review boards and institution's ethical committee, and all participants will sign a written consent before enter to study. all patients will be randomly divided into two groups, a and b. stimulation will begin on day 3 with the administration of 100 mg of clomifen citrate(cc) daily for 5 days. on day 8, ethinyl estradiol will be given daily for 5 days in group a and placebo will be given for 5 days in group b. plasma levels of estradiol(e2), luteinizing hormone (lh) and follicle-stimulating hormone (fsh) will be evaluated on days 3 and 13 of the menstrual cycle. ultrasound examination will be done on days 3, 13 and days of hcg administration and iui for determining of endometrial thickness, number of follicles and size of the dominant follicle. when the diameter of at least one follicle reached equal or greater than 18 mm, human chronic gonadotrophin (hcg) 10,000 iu will be administered. the pulsatility index also will be recorded in both uterine arteries on day of hcg administration. a single iui will be performed 24-36 hours after the administration of hcg. pregnancy will be confirmed by increasing level of concentration of serum βhcg which will be assessed 14 days after iui

Eligibility criteria:
inclusion criteria: * the patients with first treatment cycle * age between 25 and 30 years, * infertility for at least 2 years' duration, * oligomenorrhea or amenorrhea associated with a positive progesterone challenge test * women with normal concentrations of prolactin, free thyroxin and thyroid-stimulating hormone (tsh) exclusion criteria: * women whose partners had an abnormal semen analysis according to world health organization * women who had uterine or tubal abnormalities on hysterosalpingography, and women who had a body mass index of \>30 kg/m2.

Keywords: ethinyl estradiol polycystic ovary syndrome intrauterine insemination
acr | lab urine analysis test system evaluation of performance

Conditions: Diabetes; Hypertension

Summary: the acr lab is a prescription-only, nurse- or clinician-conducted in vitro diagnostic (ivd) device. the test is for the qualitative and semi- quantitative detection of albumin, creatinine, and the albumin-to- creatinine ratio. the device is composed of a kit and a smartphone application using an image recognition algorithm. the degree of agreement of the acr \| lab as compared to the comparator device will be tested. urine samples will be tested by a separate professional user on each device.


Eligibility criteria:
inclusion criteria: * men and women 18-80 years of age; * subjects who are healthy or pregnant; or * subjects diagnosed with a disease that normally represents itself with an abnormal concentration of albumin: * diabetes type i/type ii, * hypertension, * any kidney disease, * other relevant conditions. * subjects with any pathological findings which might be identified by the urine test (according to the physician discretion); * subject is capable and willing to provide informed consent; * subject has facility with both hands * subject is capable and willing to adhere to the study procedures.
comparison of myocardial injury after noncardiac surgery (mins) incidence in supine vs. prone positioning during percutaneous nephrolithotomy (pnl)

Conditions: MINS; Myocardial Injury After Noncardiac Surgery; Myocardial Injury After Noncardiac Surgery (MINS); Renal Calculi; Renal Stones; Percutaneous Nephrolithotomy (PNL); Nephrolithiasis

Summary: this prospective cohort study aims to compare the incidence of myocardial injury after noncardiac surgery (mins) in patients undergoing percutaneous nephrolithotomy (pnl) for kidney stones in supine versus prone positioning. mins is defined as an elevated postoperative troponin level (≥0.03 ng/ml) within 48 hours after surgery. approximately 400 patients will be enrolled, with 200 patients in each positioning group (supine and prone). the primary outcome is the incidence of mins, assessed through troponin measurements and electrocardiogram (ecg) findings. secondary outcomes include intraoperative complications, duration of surgery, and postoperative recovery metrics. the study seeks to determine whether surgical positioning impacts mins risk, potentially guiding safer surgical practices.

myocardial injury after noncardiac surgery (mins) is a significant perioperative complication associated with increased morbidity and mortality. this study investigates whether surgical positioning (supine vs. prone) during percutaneous nephrolithotomy (pnl) influences the incidence of mins. patients aged 18 years and older undergoing pnl for kidney stones will be enrolled in a prospective cohort study at \[institution name\]. exclusion criteria include pre-existing cardiovascular disease, elevated baseline troponin levels, or major intraoperative complications. approximately 400 patients will be divided into two groups based on surgical positioning: 200 in the supine group and 200 in the prone group. troponin levels will be measured preoperatively and at 24 and 48 hours postoperatively, with mins defined as a troponin t level ≥0.03 ng/ml. electrocardiograms (ecgs) will be performed to detect ischemic changes. secondary outcomes include intraoperative hypotension, surgical duration, and postoperative hospital stay. data will be analyzed using chi-square tests and logistic regression to adjust for confounders such as age, comorbidities, and surgical duration. the study aims to provide evidence on the impact of positioning on mins, potentially informing safer surgical protocols for pnl.

Eligibility criteria:
inclusion criteria: * age ≥40 years. * patients undergoing percutaneous nephrolithotomy (pnl) for kidney stones. * willing and able to provide informed consent. exclusion criteria: * known coronary artery disease, heart failure, or other significant cardiovascular conditions. * elevated preoperative troponin levels (≥0.03 ng/ml). * major intraoperative complications (e.g., severe bleeding requiring transfusion). * inability to comply with study procedures.

Keywords: mins pnl percutaneous nephrolithotomy myocardial injury after noncardiac surgery prone supine
evaluation of the clinical and immunological impact of two therapeutic strategies in chronic inflammatory diseases

Conditions: Inflammatory Bowel Diseases

Summary: this study evaluates 2 therapeutic strategies (increase infliximab dose or add an immunosuppressant) in patients with inflammatory bowel disease in loss of response to infliximab. addition of an immunosuppressant may be more efficient at long term and is less expensive.


Eligibility criteria:
inclusion criteria: * patients with ulcerative colitis or crohn's disease * treated with infliximab (5mg/kg per 8 weeks) and with loss of response after at least 4 infusions of infliximab * active disease ( hbi \> 5 for cd patients or sccai\> 6 for uc patients) * patients treated with infliximab only at the time of loss of response exclusion criteria: * patients with cd with ano perineal lesions and without luminal activity * patients treated with cortico steroids and having had history of intolerance to azathioprin, 6-mercaptopurine or methotrexate * patients with acute severe flare (hbi\>12 for cd patients and lichtiger score \> 10 for uc patients) * pregnant female * patients with anal disease alone

Keywords: crohn's disease ulcerative colitis infliximab loss of response
influence of preoperative anxiety on shivering during elective caesarean section under spinal anaesthesia

Conditions: Shivering

Summary: background shivering occurs in circa 50 percent of cases during caesarean section under spinal anesthesia. the phenomenon's reasons and its mechanism are unclear, and while it does not endanger the patients' health, the sensations proved to be unpleasant and a subject of a number of patients' complains. objectives the main objective of the study is to establish the anxiety factors that influence the risk of muscle-shivering and a detailed assessment of the probability of existence of the link between increased anxiety levels with the shivering in case of patients undergoing the elective caesarean section. moreover, the outcomes of the study could help to further understand the phenomenon, reduce its occurence and as a result of that - improve the comfort of the patients in the perioperative period, as well as reduce the frequency of pharmacological treatment to halt the symptoms of muscle shivering. methodology patients would be asked to fill the stai (state - trait anxiety inventory) questionaire in the morning preceding the surgery. results would be interpreted by one of the investigators, who obtained a masters degree in psychology. caesarean section under spinal anesthesia would be performed according to standard procedures used in the samodzielny publiczny szpital kliniczny centrum medyczne kształcenia podyplomowego (spsk cmkp) hospital, with standard non-invasive monitoring (hr, noninvasive blood pressure (nibp), oxygen saturation (spo2), temperature). additionally, the anesthesiologist would note the incidence of shivering and its precise timing 1. since the spinal block 2. since the child-birth. moreover, patients would rate anesthesiology team influence on her anxiety level during the cesarean section in 5 grade scale - data would be collected by psychologist. the survey is planned for a one year timespan or until 200 patients have enrolled.


Eligibility criteria:
inclusion criteria: * age \> 18 y.o. * asa 1-2 * signed informed consent form after reading the information about the study and talking with one of the investigators exclusion criteria: * conversion to general anesthesia * any severe obstetric complications, which affects obstetric or anesthesiology procedure * severe bleeding * language barrier * anxiolytic/psychotropic drugs use

Keywords: shivering, cesarean section, anxiety, stai
usage of stainless steel crown on primary molars using hall technique

Conditions: Knowledge, Attitudes, Practice

Summary: rationale: gaining information about the knowledge, practice and attitude regarding hall technique and find out how much the egyptian dentists use this method for treatment the carious primary teeth. aim of the study: to assess the knowledge, practice and attitude of egyptian dentists regarding non invasive restorative approach.

the first study on the hall technique was published in 2006 . it was a retrospective study which analysed the practice records of a general dental practitioner from scotland, dr. norna hall. dr. hall simplified the standard technique to restore primary teeth using preformed sscs and used it with her patients. this retrospective study involved a total of 978 crowns fitted in 259 children using her novel technique (today known as the hall technique). most crowns were placed when there was clinical evidence of a proximal carious lesion into dentine and marginal ridge breakdown. this study showed the hall technique to have comparable outcomes to those achieved with other more conventional restorations. since then, growing understanding that caries is essentially a biofilm driven disease rather than an infectious disease, explains why the hall technique, and other 'sealing in' carious lesion techniques, are successful. the intervening ten years has seen robust evidence from several randomised control trials that are either completed or underway. these have found the hall technique superior to comparator treatments, with success rates (no pain or infection) of 99% (uk study) and 100% (germany) at one year, 98% and 93% over two years (uk and germany) and 97% over five years (uk). the hall technique is now regarded as one of several biological management options for carious lesions in primary molars.

Eligibility criteria:
inclusion criteria: 1. egyptian dentists. 2. pediatric dentists ( having phd). 3. pediatric dentists (having master degree or studying master degree) . exclusion criteria: 1. dentists in other dental speciality. 2. dental students. 3. pediatric dentists who have not enough knowledge about hall technique.
acute coronary syndrome in diabetic patients

Conditions: Acute Coronary Syndrome; Diabetes Mellitus; Heart Failure; Acute Pulmonary Edema; Cardiac Arrythmias

Summary: this study aims to compare the clinical profile and outcomes of acute coronary syndrome patients with diabetes and without diabetes.

adult patients (≥ 18 years of age) with acute coronary syndrome which are diagnosed under international classification of disease (icd-10) coding of i24.9 were included in this study. the inclusion criteria are patients with primary diagnosis of i24.9 and with a complete record of prior medical and treatment history, electrocardiographic findings, cardiac marker results and outcomes. participants were grouped into 2 groups - diabetic and non-diabetic based on history of diabetes prior to acs. diagnosis of acs was made based on clinical, electrocardiographic and cardiac marker findings found in the medical record. data such as age, sex, ethnic, education, prior medical and treatment history, electrocardiographic and cardiac enzyme results as well as outcomes were collected from the patients' medical records. outcomes of interest were defined as either concomitant heart failure, acute lung edema, malignant arrhythmia, mortality or combinations of them as diagnosed in the medical records. heart failure is defined based on echocardiographic findings from the medical records. acute lung edema is defined based on medical records or reported clinical findings of lung edema - rhonchi reported in 1/3 of the lungs with oxygen saturation \<90%. whereas malignant arrhythmia is defined as the presence of ventricular tachycardia (vt) or ventricular fibrillation (vf).

Eligibility criteria:
inclusion criteria: * clinical diagnosis of acute coronary syndrome * presence of detail on diabetes history exclusion criteria: * unavailability of electrocardiographic findings, cardiac marker results * incomplete records of prior medical and treatment history

Keywords: acute coronary syndrome diabetes heart failure acute pulmonary edema malignant arrhythmia
manual manipulation and ex vivo flexible ureteroscopic lithotripsy to salvage deceased donor kidneys with renal stones: a case series

Conditions: Manual Manipulation and Ex Vivo Flexible Ureteroscopic Lithotripsy to Salvage Deceased Donor Kidneys With Renal Stones:a New Method by

Summary: we report the manual manipulation and ex vivo flexible ureteroscopic lithotripsy to salvage deceased donor kidneys with renal stones,including nine cases,renal transplantation was performed with the treated kidney after removing the stones, and the short-term postoperative outcomes were promising. cases were thoroughly reported in this paper.

the presence of donor kidney stones may lead to ureteral obstruction after transplantation, affecting the recovery of postoperative renal function. thus, donors with kidney stones are often considered marginal kidney donors and likely disqualified,here we describe a series case of multiple kidney stones in a donor kidney treated with the combined application of furs and holmium laser lithotripsy (hll) before transplantation. renal transplantation was performed with the treated kidney after removing the stones, and the short-term postoperative outcomes were promising. the case was thoroughly reported in this paper.

Eligibility criteria:
inclusion criteria: * get renal transplantation donor kidney with stones exclusion criteria: * without renal stones the renal stones without ex vivo flexible ureteroscopic lithotripsy

Keywords: organ donation; kidney transplantation flexible ureteroscopy;