Kornimate/medical-research-clean huggingface dataset:
evaluation of robotic exoskeletons therapy for gait rehabilitation in patients with incomplete spinal cord injury.

Conditions: Spinal Cord Injury; Incomplete Spinal Cord Injury

Summary: the objective of the study is to assess the efficacy of the exo-h2 robotic exoskeleton for walking rehabilitation of people with incomplete spinal cord injury.

the recovery of walking ability is a primary concern of rehabilitation programs for people who have suffered anincomplete spinal cord injury. robotic therapy arises from the new concepts of neuroplasticity. one of the most novel contributions in this field is robotic exoskeletons. however, there is still not enough scientific evidence to support the clinical use of this technology. the aim of this proposal is to assess the efficacy of a new model of robotic exoskeleton (exo h2) developed by the csic with hnp involvement in the context of hyper project (consolider 2009 call) in gait rehabilitation for people with incomplete spinal cord injury. a multicenter study is proposed here, involving the national hospital of paraplegics and the institut guttmann. two randomized groups of patients with subacute incomplete spinal cord injury will be defined. in one group, protocol gait rehabilitation based on the exo h2 will be established and traditional gait therapy will be adapted for control group. both groups of patients were assessed performing a physical exam including functional gait scales (10 mwt, 6mwt, wisci ii score, scim) and a biomechanical gait analysis with kinetic and kinematic techniques. functional assessment will be carried out before intervention, at the end of the intervention and a follow up six weeks later.

Eligibility criteria:
inclusion criteria: * incomplete spinal cord syndrome, asia scale c or d * enough strength in the upper extremities to handle a walker or crutches (triceps brachial muscle balance ≥ 3) * age between 16 and 70 y.o. * heigth: 1.6-1.9m * weigth less than 120kg * stable medical condition between 6 weeks and 18 months since injury. * subjects must tolerate standing and be included in walking rehabilitation program in the center. * lower limb spasticity should be lower than 3 as measyred by ashworth scale. exclusion criteria: * cardiovascular diseases. * upper limb pathology of any kind. * irreducible flexo or arthrodesis in lower limb joints, 2 or more osteoporotic fractures in the lower limbs in the last 2 years * uncontrolled epilepsy. * ulcers sores at the contact points with the exoskeleton. * refuse to participate.

Keywords: incomplete spinal cord injury walking rehabilitation robotic exoskeleton
cardiopulmonary rehabilitation in heart valve surgery

Conditions: Heart Valve Diseases

Summary: the aim of this study was to investigate the effects of postoperative early mobilization and bottle-p.e.p. application on respiratory parameters and functional capacity in patients undergoing heart valve surgery.

after all patients were informed about the study and potential risks, patients who gave informed consent will be evaluated preoperatively and 5-7 days after surgery by the same investigator. patients will be randomly divided into 3 groups: group i (n=20, control) - conventional cardiopulmonary rehabilitation, group ii (n=20), conventional cardiopulmonary rehabilitation and bottle p.e.p. application, group iii (n=20) will be included in the study as conventional cardiopulmonary rehabilitation and early mobilization group. the respiratory parameters of the patients will be determined by a pulmonary function test and their functional capacities will be determined by a 6-minute walk test. the preoperative and postoperative periods will be compared with statistical methods in the light of these evaluations on days 5-7.

Eligibility criteria:
inclusion criteria: * after heart valve surgery: patients undergoing valvular surgery via sternotomy * same surgical technique (from med-sternum) * age group (25-75 y) * stable hemodynamic values (stable vital signs, normal temperature, etc.) * full awareness of time and space exclusion criteria: * ejection fraction 35 % * any male/female patient \&lt;25 or \&gt;75 * body mass index (bmi) ≥ 38 kg/m2 * intubation time \&gt;6 hours after surgery * uncontrolled arrhythmias * rheumatoid arthritis, other inflammatory and autoimmune diseases * active malignancy * cardiac pacemaker or defibrillator * mental health disorders * any postoperative complication (general muscle weakness, wound infection of the sternum or leg, stroke.) * refusal to assist in data collection

Keywords: heart valve surgery bottle-p.e.p. early mobilization cardiopulmonary rehabilitation
effects of a paleolithic lifestyle intervention in breast cancer patients undergoing radiotherapy

Conditions: Breast Cancer; Body Weight Changes

Summary: the study aims to test the feasibility and effects of a dietary and physical activity intervention based on evolutionary considerations in an oncological setting.

a total of 13 breast cancer patients referred to our clinic for curative radiotherapy were recruited for this pilot study. the women were supposed to undertake a "paleolithic lifestyle" (pl) intervention consisting of a paleolithic diet and daily outdoor activity of at least 30 min duration while undergoing radiotherapy. body composition was measured weekly by bioimpedance analysis. blood parameters were assessed before, during, and at the end of radiotherapy. a control group on an unspecified standard diet (sd) was assigned by propensity score matching.

Eligibility criteria:
inclusion criteria: * body mass index \>18 kg/m\^2 * karnofsky performance index \>60 exclusion criteria: * metallic body parts * unable to comprehend the intervention

Keywords: bioimpedance analysis body composition nutrition oncology paleolithic diet
hypofractionated radiation by cyberknife as a mean of the tumor site's radiation after conventional breast radiation.

Conditions: Breast Cancer

Summary: the cyberknife (ck) has been developed recently. this is a linear accelerator carried by an industrial robot. it has, due to its tumor tracking capabilities and high accuracy, an interest in irradiation (boost) of tumor site after conventional irradiation. the radiation boost is currently issued by electrons, protons or brachytherapy. these techniques require several fractions and are associated with cutaneous toxicities and aesthetic problems. ck has an interest in reducing the number of fractions and a reduction of dose delivered to the skin. ck has been used in a phase i protocol (cyberneo) with concomitant chemotherapy for inoperable breast tumors and has proven its effectiveness and safety of treatments. the investigator is considering conducting a phase ii protocol to a single dose of 8 grays issued by ck for boost to the tumor site after conventional breast irradiation. the results, in terms of local control, will be evaluated on clinical monitoring.


Eligibility criteria:
inclusion criteria: 1. unifocal breast cancer histologically proven 2. age\> 18 years old, in good general condition (ecog 0-2) 3. no cons-indication for radiotherapy 4. patient who underwent lumpectomy and axillary dissection or sentinel node technique. 5. carcinoma histology ductal or lobular carcinoma 6. surgical margins microscopically without residual disease (\> 1 mm) 7. tumors classes t1 or t2, n0 exclusion criteria 1. residual calcifications on x-ray examination 2. inflammatory breast cancer, ductal (and / or in situ) and invasive lobular 3. multifocal breast cancer 4. prior breast radiotherapy 5. patient who received chemotherapy
monitoring of chimerism after transplantation in patients with β thalassemia major and the treatment strategies for the reduction of chimerism

Conditions: Beta Thalassemia Major

Summary: hematopoietic stem cell transplantation is currently the only way to cure thalassemia, one of its main obstacles is the rejection after transplantation, chimerism continued to decline, which eventually lead to transplant failure. chimerism is a key indicator of the succession of immune response, which is a key indicator for predicting the failure of hematopoietic stem cell transplantation and provides an important basis for early detection of rejection. transplantation of continuous chimerism can detect early unstable chimeras and rejection.the chimerism rates after transplantation were continuously monitored using fluorescence labeled multiplex pcr amplification of short tandem repeats (str-pcr) ,and then follow our str different rates for early interventional therapy to prevent further reduction in chimerism leading to lead to graft failure.


Eligibility criteria:
inclusion criteria: 1. diagnosis of thalassemia major 2. there is no restriction on age or gender. 3. underwent allogeneic hematopoietic stem cell transplantation, including sibling transplantation, unrelated transplantation and haploidentical transplantation. 4. on +45 day after transplantation, check patients with str less than 80%. 5. patients underwent reduce of dosage with a failure treatment by 6. body condition score (ecog score) is less than or equal to 1 point who meet follow-up conditions. exclusion criteria: complicated with severe cardiac insufficiency and cardiac ejection fraction (ef) was lower than 50%. complicated with severe pulmonary insufficiency (obstructive and / or restrictive ventilatory disorders). complicated with severe liver function damage and liver function index (alt or tbil) is more than 2 times of the upper limit of the normal value. complicated with severe renal dysfunction and renal function index (cr or bun) is 2 times of the upper limit of the normal value. complicated with severe active bleeding

Keywords: thalassemia transplantation chimerism donor ymphocytes
nt-probnp in icu postoperative/posttraumatic patients with shock

Conditions: SIRS; Sepsis; Shock; Critically Ill; Multiple Organ Dysfunction Syndrome

Summary: the purpose of this study is to determine the course of nt-probnp plasma concentrations in the context of confounding parameters in postoperative/posttraumatic critically ill patients with severe sirs/sepsis and shock.

in the recent sepsis-definitions, myocardial depression is included in the definition of severe sepsis, indicated as lowered cardiac index or echocardiographically documented cardiac dysfunction. myocardial dysfunction occurs in greater than 50% of patients with severe sepsis and septic shock. in this context, b-type natriuretic peptid (bnp) from ventricular myocytes may serve as a surrogate biomarker for the evaluation and quantification of myocardial dysfunction. biologically active bnp is cleaved into inactive nt-probnp, which is supposed to be a better marker of myocardial dysfunction and prognosis in patients with severe sepsis and septic shock. however, severity of illness dependent association of myocardial dysfunction, especially left ventricular diastolic function, dosage of norepinephrine, nt-probnp and biomarker plasma concentrations has not been systematically investigated in postoperative/posttraumatic patients in septic shock or volume-deficiency/hemorrhagic shock. moreover, data regarding nt-probnp plasma concentrations and renal function in postoperative/posttraumatic patients are sparse. therefore, this prospective observational study will enroll n= 200 postoperative/posttraumatic patients to monitor longitudinally nt-probnp, biomarkers, and cell surface markers on leukocytes to find out whether there is a discriminating pattern of myocardial dysfunction, nt-probnp and biomarkers in patients with non-septic or septic shock, respectively, and with beneficial or harmful outcome.

Eligibility criteria:
inclusion criteria: * critically ill, postoperative/posttraumatic patients with severe systemic inflammatory response syndrome (sirs) or severe sepsis exclusion criteria: * life expectancy \< 24 hours * participation in other trials * known or suspected pregnancy * contraindications for transesophageal echocardiography (tee): severe disease of the esophagus (hernia, strictures, esophageal resection, severe bleeding disorders)

Keywords: nt-probnp myocardial dysfunction humans patients polytrauma complement inflammation inflammatory response biomarkers cytokines cell surface markers functional polymorphisms infections systemic inflammatory response syndrome sirs sepsis severe sepsis shock organ dysfunctions sofa severity of disease apacheii sapsii spaps3 length of stay outcome mortality
the color of itch; itch modification by color viewing

Conditions: Itch; Pruritus

Summary: itch is the commonest skin-related symptom. there is increasing evidence that itch can be influenced by visual cues. the impact of colors on itch has not yet been studied. this study investigates itch modification by color viewing and whether patients can match or counteract their itch with a color.


Eligibility criteria:
inclusion criteria: * dermatology in- and outpatients with itch exclusion criteria: * color blindness * lack of time * lack of german language.

Keywords: contagious itch manchester color wheel
caudal versus rectus sheath study

Conditions: Umbilical Hernia

Summary: the literature has clearly demonstrated that the effective treatment of postoperative pain in infants and children is challenging. in an effort to improve postoperative analgesia while limiting opioid-related adverse effects, there continues to be an increased use of regional anesthetic techniques in infants and children. although the pediatric caudal remains the most commonly used pediatric regional anesthetic technique, it has been demonstrated that effective analgesia can be provided with the use of peripheral nerve blockade even in the pediatric-aged patient. the purpose of this study is to prospectively compare post-operative pain relief in pediatric patients undergoing umbilical hernia repair who have received either a caudal block or bilateral rectus sheath blocks for analgesia


Eligibility criteria:
inclusion criteria: * asa physical status i or ii * weight less than or equal to 20 kg * presenting for repair of umbilical hernia exclusion criteria: * asa physical status \> ii * weight greater than 20 kg * co-morbid diseases (cardiac, pulmonary, neurological disease) * patients having concomitant procedures (circumcision, orchiopexy, etc.)
study of a potential new treatment for patients with toxic epidermal necrolysis (ten)

Conditions: Toxic Epidermal Necrolysis

Summary: to determine whether treatment of patients who have toxic epidermal necrolysis with a drug called remicaide increases the number of patients who are alive 30 days laters.

this is a pilot (preliminary) study. patients with a diagnosis of ten will be asked to consider participating. the study intervention is a single intravenous dose of remicaide (5 mg/kg). standard supportive care will be given. the percentage of patients alive at 30 days after treatment with remicaide will be compared to historical controls.

Eligibility criteria:
inclusion criteria: * admission to burn unit with a histologic diagnosis of tens exclusion criteria: * pregnancy * hypersensitivity to remicaide * history of heart failure * documented bacteremia * history of cancer * inability to consent

Keywords: toxic epidermal necrlysis ten
percutaneous cochlear implantation: implementation of technique

Conditions: Hearing Loss

Summary: the investigators are studying a new way of doing cochlear implant surgery called "percutaneous cochlear implantation". in this surgery, instead of doing a mastoidectomy where about 30ml of bone is removed, the investigators use image-guided technology (similar to gps systems used to guide automobile travel) to drill directly from the surface of the skull to the cochlea, removing less than 2ml of bone. to use this technique, three markers (or anchor screws) are screwed into the bone around the ear. next, an x-ray of the head (called a ct scan) is taken. using this ct scan, a path to the inner ear (cochlea) is planned and a drill guide (microtable) is made that mounts on the anchor screws. a drill will be attached to the guide and used to drill a path from the surface of the skull to the inner ear (cochlea). the implant electrode will be threaded through this path. all of these procedures take place under general anesthesia.


Eligibility criteria:
inclusion criteria: * 18-80 year old patients undergoing cochlear implantation who are able to participate in the informed consent process. * pre-operative ct scan of head performed as standard of care for cochlear implant work-up. exclusion criteria: * patients with co-morbidities so severe that the potential additional operating room time is deemed to be too significant of an operative risk. this assessment is made by the local institutions pre-operative work-up. * history of allergic reaction/intolerance of local anesthesia and/or epinephrine. * history of allergic reaction to titanium. * patients with severe anatomical abnormality of the temporal bone. * patients with severe chronic ear disease for whom traditional mastoidectomy might offer benefit. * females who are pregnant.

Keywords: hearing loss cochlear implantation image guided surgery
management of covid-19 patients during home isolation

Conditions: Covid 19

Summary: this study will be concerned with managing patients of covid-19 while being home isolated.


Eligibility criteria:
inclusion criteria: * patients with covid-19 * american society of anesthesiologists (asa) class i * \>= 21 years old * \<= 40 years old exclusion criteria: * asa class ii, class iii or class iv
compare the renal protective effects of febuxostat and benzbromarone

Conditions: Chronic Kidney Disease; Hyperuricemia; Abnormal Renal Function

Summary: the purpose of this study is to determine whether febuxostat and benzbromarone could protect renal function, and which one could be better.

chronic kidney disease patients with hyperuricemia and glomerular filtration rate (gfr) 20-50 ml/min were treated by febuxostat or benzbromarone. follow up the changes of serum uric acid, serum creatinine and gfr levels. compare the effects on renal function of these two drugs.

Eligibility criteria:
inclusion criteria: chronic kidney disease patients with glomerular filtration rate (gfr,20-50ml/min) who match one of the following criteria: 1. gout 2. hyperuricemia patients without gout but have cardiovascular risk and serum uric acid \> 480umol/l 3. hyperuricemia patients without gout but with serum uric acid \> 540umol/l exclusion criteria: 1. gfr\ 50ml/min 2. liver dysfunction (aspartate transaminase or/and alanine aminotransferase exceed 2 times of normal range) 3. urinary tract obstruction 4. unstable angina, heart failure (stage iii-iv, nyha), new stroke, need diuretics for long-term treatment 5. severe lung diseases or cancers 6. pregnant woman or woman who prepare to be pregnant，nursing mothers 7. unable to sign informed consent form，or disagree with following-up

Keywords: hyperuricemia renal function chronic kidney disease febuxostat benzbromarone
the effect of hot foot bath on sleep quality and fatigue

Conditions: Hepatitis B

Summary: this study will be conducted to investigate the effects of hot foot baths on patients' sleep quality and fatigue severity levels.the study will be conducted in the gastroenterology clinic of a university hospital in türkiye. the research sample will consist of 60 adult patients. patients will be randomly divided into two groups: the intervention and control groups. the intervention group will receive hot foot baths for three consecutive nights starting from the second day of hospitalization. the foot bath will be applied one hour before the patient goes to bed at night. the foot tub will be filled with hot water to approximately 20 cm above the patient's ankle and the temperature of the water will be measured with a water thermometer. the temperature of the water will be kept stable at 41-42°c. this application will be done for 20 minutes. the sleep and fatigue levels of the patients will be measured with measurement tools in the morning (3 times) following each application. no application will be applied to the control group, and sleep and fatigue levels will be measured in a similar manner to the measurement tools applied to the intervention group and the application days.


Eligibility criteria:
inclusion criteria: * being over the age of 18, * having no disorder which could affect pain perception, * having no communication problem, and voluntarily agreeing to participate in the research, * having been admitted to the clinic at least 24 hours ago, * not having a diagnosed sleep disorder, * not having a psychiatric disorder requiring treatment, * not having a problem with vital signs before the application, * not using narcotic drugs in the last 4 hours, * not eating two hours before going to bed at night exclusion criteria: * being under the age of 18 * not being conscious, refusing to participate in the research or opting to leave the study at any point, * having a problem with vital signs before the application, * having a diagnosed sleep disorder.

Keywords: fatigue sleep quality foot bath
an online behavior change intervention to promote physical activity in adults with asthma

Conditions: Asthma; Sedentary Behavior; Physical Inactivity

Summary: the aims of this study are to investigate the effectiveness of an online behavior change (bc) intervention in increasing physical activity (pa) and reducing sedentary behavior in adults with asthma, as well as, in improving other clinical outcomes, in short and medium term. in this single-blind randomized clinical trial, patients with clinically stable moderate to severe asthma, who are physically inactive and do not have cardiovascular and/or osteoneuromuscular impairments will be randomized into control (cg) or intervention (ig) groups (23 in each group). both groups will carry out a minimum educational program. additionally, the ig will receive weekly individual and/or group online sessions for 12 weeks of motivation-based bc intervention to promote pa and reduce sedentary behavior, based on both self-determination theory (sdt) and transtheoretical model (ttm). the ig will also receive a pedometer with specific strategies related to it. both groups will be reassessed immediately after the intervention as well as 6 months after the end of the intervention. the primary outcomes are pa and sedentary behavior, which will be objectively assessed by a triaxial accelerometer (actigraph wgt3x-bt). secondary outcomes are: asthma control, functional capacity, quality of life, sleep quality and symptoms of anxiety and depression.


Eligibility criteria:
inclusion criteria: * people aged from 18 to 60 years * diagnosis of moderate to severe asthma, who underwent drug treatment for at least 6 months * clinical stability for at least 1 month (without hospitalizations, emergency care use or medication changes) * absence of cardiovascular and/or osteoneuromuscular diseases that could interfere/hinder the performance of tests and physical activity * absence of lung diseases other than asthma * preserved cognitive function * non-smokers or ex-smokers with \<10 pack-years * report being physically inactive in accordance with current physical activity guidelines * able to make video calls through any platform and/or free app available exclusion criteria: * presence of any new orthopedic limitation that hinders the performance of physical activity during the study * perform ≥150 minutes per week of moderate to vigorous physical activity during the initial assessment