Kornimate/medical-research-clean huggingface dataset:
prevention of radial artery occlusion: comparison of three hemostatic methods in transradial intervention

Conditions: Occlusion of Artery; Radial Artery Injury; Complication

Summary: this study evaluates three hemostatic methods for prevention of radial artery occlusion. one third of patients will receive patent hemostasis, another third will receive patent hemostasis plus ulnar compression and the last third will receive the statseal hemostatic disc.

the main complication of the transradial access is the occlusion of the radial artery, which although clinically silent in most cases, has been associated with critical hand ischemia, more importantly it limits the radial approach for future coronary interventions, and limits the use of this conduit for coronary revascularization surgery and arteriovenous fistulas. factors that prevent occlusion of the radial artery have been identified, including the use of several hemostatic techniques at the conclusion of cardiac catheterization. the patent hemostasis defined as a technique that allows permeability of the radial artery and at the same time ensures the absence of bleeding was the first hemostatic method that showed a decrease in the incidence of radial artery occlusion, it is currently the quality standard for hemostasis in transradial access worldwide. recently, the patent hemostasis plus ulnar compression was described, which proved in a randomized clinical trial to be superior to conventional patent haemostasis, decreasing the incidence of radial artery occlusion to 0.8% at 30 days. these hemostatic methods are a subject of current research worldwide. and more clinical trials are expected to confirm the superiority of patent hemostasis plus ulnar compression. the hemostatic discs used at the beginning as an attempt to reduce the times for the hemostasis of the radial access and therefore the recovery times in units of high volume have attracted attention for their effectiveness and their low incidence of radial artery occlusion, there are few reports who place it as a potential strategy to reduce the incidence of radial artery occlusion. its effectiveness should be validated in dedicated trials with an adequate sample size.

Eligibility criteria:
inclusion criteria: * patients over 18 years of age, both genders, in whom successful transradial access is obtained for elective and urgent diagnostic or therapeutic coronary procedures. exclusion criteria: * patients over 18 years of age, both genders, in whom successful transradial access is not achieved and crossover is performed to femoral access. * patients over 18 years of age, both genders, who do not give their informed consent to participate in the study. * patients over 18 years, both genders, with cardiogenic shock.

Keywords: radial artery occlusion prevention patent hemostasis transradial intervention ulnar compression
identification of clinical, biometrical and operatory factors related to pain during cataract surgery

Conditions: Cataract

Summary: adults who undergo cataract surgery will be questioned after surgery about the eventual pain they experienced, about their health history, personal treatment. if they accept to be included in the study we'll record different parameters related to the surgery: type of anesthesia, duration of surgery, machines used, unexpected events, particularities noticed by the surgeon, etc. there will be no unusual intervention, everything will be run exactly as if there was no study. no additional consultation needed.

adults who undergo cataract surgery, excepting under general anesthesia, will be asked to rate a visual analog scale grading the pain they experienced, about their health history, personal treatment. if they accept to be included in the study we'll record different parameters related to the surgery: visual analog scale of pain according to the surgeon (before recording the patient), type of anesthesia, duration of surgery, machines used, time of ultrasound used for phakoemulsification, preoperoative visual acuity and intraocular pressure, biometry, iris color, preoperative donesis, preoperative capsular pseudoexfolliation, unexpected events, particularities noticed by the surgeon as floppy iris syndrome, lens-iris diaphragm retropulsion syndrome there will be no unusual intervention, everything will be run exactly as if there was no study. no additional consultation needed.

Eligibility criteria:
inclusion criteria: * undergoing a cataract surgery during the period of inclusion, and by one of the surgeons of the study * majority 18 years and more exclusion criteria: - general anesthesia

Keywords: cataract surgery phakoemulsification pain biometry anesthesia
plaque stratification using ccta in coronary artery disease (postcard)

Conditions: Coronary Artery Disease

Summary: develop time-to-event prediction and plaque phenotype classification models for patients with known or suspected coronary artery disease.

develop time-to-event prediction and plaque phenotype classification models using plaque morphology and composition assessment of cta which has been validated by histology, applied to representative cohort of patients. generalizability of models is enhanced by using validated rather than only raw image inputs. demographic, clinical, and outcome data is collected for enrolled patients as well as last known well dates.

Eligibility criteria:
inclusion criteria: * subject must have successfully completed at least one (possibly multiple) ccta for known or suspected coronary artery disease, which was positive for coronary atherosclerotic changes. * subject must have been ≥ 18 years of age at the time of the ccta exclusion criteria: * subject has a history of percutaneous coronary intervention (pci) with stent implantation and/or coronary artery bypass grafting (cabg) * ccta taken less than 3 months after deployment of new scanner * subject with insufficient ccta image quality
dexamethasone in total knee and total hip arthroplasty

Conditions: Total Knee Arthroplasty; Total Hip Arthroplasty; Osteoarthritis

Summary: this study will evaluate if the addition of dexamethasone to a local infiltration analgesia mixture will improve functional outcomes following total hip and knee arthroplasty.

the addition of dexamethasone to an local infiltration analgesia (lia) mixture for postoperative analgesia following total knee arthroplasty (tka) has a limited evidence base. although there is increasing support in the literature for its use in peripheral nerve blockade, there have only been a handful of studies assessing its applicability in periarticular lia. moreover, the evidence from peripheral nerve blocks suggests that one of the key benefits of dexamethasone is a prolongation of nerve blockade. additionally, dexamethasone has been shown to prolong the local analgesic effect of bupivacaine microcapsules. with respect to total hip arthroplasty (tha), there have only been two small studies that included corticosteroids in the lia mixture; there was analgesic benefit and better early rehabilitation outcomes when compared to placebo. however, there is limited high-quality evidence for either tha or tka demonstrating an improvement in functional outcomes when dexamethasone is used in an lia mixture. this study will evaluate if the addition of dexamethasone to a local infiltration analgesia mixture will improve functional outcomes following total hip and knee arthroplasty.

Eligibility criteria:
inclusion criteria: * undergoing elective, primary, unilateral total hip or knee arthroplasty under spinal anesthesia * asa-ps i-iii * 18-85 years of age, inclusive * 50-100 kg, inclusive * bmi 18 - 40 exclusion criteria: * revision hip/knee arthroplasty * bilateral hip/knee arthroplasty * inability or refusal to provide informed consent * any contraindication to spinal anesthesia (e.g., bleeding diathesis, infection, neuropathy) * allergy to local anesthesia, ketorolac or dexamethasone * allergy to opioids * chronic pain state, neuropathic pain * opioid dependence * diabetic patients will not be excluded except those with significant peripheral neuropathy
imaging study of 18f-fac pet scans to assess standard treatment in people with pancreatic cancer

Conditions: Pancreatic Cancer; Pancreatic Ductal Adenocarcinoma

Summary: the purpose of this study is to find out whether a pre-treatment pet scan using the experimental imaging tracer 18f-fac can show how much of the standard chemotherapy for pdac may be taken up by the cancer.


Eligibility criteria:
inclusion criteria: * patients with histologically-confirmed (confirmed at mskcc) pdac * patients must be ≥ 18 years old * signed, written institutional review board (irb)-approved informed consent form (icf). * measurable or evaluable solid disease on computed tomography (ct) or magnetic resonance imaging (mri) scan per recist v1.1. * karnofsky performance status ≥70%. * life expectancy ≥3 months. * a negative serum pregnancy test, within 1 week of the procedure, if the patient is female of reproductive potential. exclusion criteria: * patients who cannot undergo pet/ct scanning (i.e. because of weight limits, claustrophobia). * women who are pregnant or breast-feeding.

Keywords: pancreatic cancer pancreatic ductal adenocarcinoma 18f-fac memorial sloan kettering cancer center 21-442
pi vs. nnrti based therapy for hiv advanced disease

Conditions: Acquired Immunodeficiency Syndrome

Summary: ritonavir boosted protease inhibitor based therapy will have equivalent antiviral efficacy over 48 weeks compared to nnrti based therapy in patients who are antiretroviral therapy naïve and initiate therapy with cd4 counts ≤ 200/mm3.

current guidelines for initial therapy in hiv infection recommend 2 nrtis plus either a ritonavir boosted protease inhibitor or a non-nucleoside reverse transcriptase inhibitor (nnrti). recent data suggests that the rate of response to pi based therapy may be slightly compromised if the baseline cd4 count is ≤ 200/mm3 and the plasma hiv-1-rna ≥ 100,000 copies/ml. this may not be equally apparent if ritonavir boosted protease inhibitors are used. the effect of baseline cd4 count and hiv-1-rna levels on the antiviral efficacy of nnrti based regimens has been less well characterized. a significant number of patients currently initiate therapy at late stages of progression, typically with baseline cd4 count is ≤ 200/mm3. in mexico approximately 60% of patients who initiate therapy are within this range of cd4 cell counts. currently, the two combinations recommended as preferred are with two nrtis and either efavirenz or lopinavir/ritonavir, while other combinations of pis and ritonavir are considered alternative. comparison: the efficacy of ritonavir boosted protease inhibitor based therapy versus nnrti based therapy in patients who are antiretroviral therapy naïve and initiate therapy with a cd4 count ≤ 200/mm3.

Eligibility criteria:
inclusion criteria: * hiv infected individuals * men or women at least 18 years old * cd4+ t cells ≤200/ml * antiretroviral naive exclusion criteria: * suspected or documented active, untreated hiv 1 related opportunistic infection (oi) or other condition requiring acute therapy (e.g., hepatitis c virus infection) * platelet count \< 75,000 cells/mm3. * hemoglobin \< 9 g/dl . * ast and/or alt greater than 5 times the upper limit of normal * documented or suspected active tuberculosis

Keywords: acquired immunodeficiency syndrome antiretroviral therapy, highly active protease inhibitors reverse transcriptase inhibitors
barriers and faciliators for physical activity in people with rmds

Conditions: Osteoarthritis, Knee; Osteoarthritis, Hip; Rheumatoid Arthritis; Axial Spondyloarthritis

Summary: the aim of this project is to systematically survey and explore barriers and facilitators for the implementation of physical activity according to the physical activity recommendations of the european alliance of associations for rheumatology on country specific (e.g., environmental, cultural, organization and system) level. a questionnaire to explore/identify these barriers and facilitators in the survey, will be developed through literature search, interviews with multiple stakeholders (i.e., patients with inflammatory arthritis or osteoarthritis and physical therapists) and experts in the field in four different european countries (i.e., turkey, switzerland, the netherlands and france). additionally, in switzerland only, the inflammatory arthritis facilitators and barriers to physical activity (ifab) questionnaire which was developed to determine the factors on personal level, will be translated into the german language. aim is to evaluate the validity and reliability of the ifab questionnaire in the german-speaking population with axial spondyloarthrits, and to perform a cultural adaptation if necessary at the same time.


Eligibility criteria:
inclusion criteria: * adults being 18years or older * diagnosis of osteoarthritis, rheumatoid arthritis or axial spondyloarthritis * the cognitive and linguistic competencies to answer the survey exclusion criteria: * having a rheumatological or musculoskeletal disease other than described * any communication problems
comparison of the two and six- minute walk tests in evaluating oxygen desaturation in patients with severe copd

Conditions: Chronic Obstructive Lung Disease

Summary: all measurements are performed on two consecutive days at the beginning of a pulmonary rehabilitation program in a randomized cross-over study design. on the first day, each patient is randomly assigned to perform either the 2 minute walk test or the 6 minute walk test. on the second day each patient performs the test that was not performed on the first day. all walk tests are performed by the same investigator on the same track and time of day, following the 2002 guidelines of the american thoracic society. patients wear a mobile pulse oximeter that continuously records heart rate and oxygen saturation during testing. baseline values of oxygen saturation, heart rate and ratings of perceived exertion on the modified borg scale (0 to 10) for dyspnea and leg fatigue are recorded at rest after 10 minutes of sitting.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of chronic obstructive lung disease stage iii or iv according to the global initiative for chronic obstructive lung diseases definition * ability to read and understand the german language and study procedures. * written informed consent exclusion criteria: * severe acute exacerbation of chronic obstructive lung disease * severe respiratory failure (partial oxygen pressure at rest lower than 55 millimeter mercury) * non compliance to the study protocol.
early prevention of post traumatic stress disorder

Conditions: Post Traumatic Stress Disorder

Summary: sunnybrook health sciences centre is canada's largest trauma centre, treating 1,100 patients annually. a traumatic experience can lead to post-traumatic stress disorder, which increases hospital stays, emergency visits and disability. despite developing leadership to manage a "code orange" mass trauma, sunnybrook lacks guidelines in the psychological management of patients who have experienced trauma. the department of psychiatry currently holds a traumatic brain injury clinic and ptsd services for youth but lacks both immediate intervention, prevention and adult services. this research will enable us to gain best evidence expertise to develop guidelines as well as a sustainable ptsd treatment program, with clear outcomes to assess effectiveness, psychiatric morbidity, use of healthcare, disability and substance abuse. the five world-expert-consensus intervention resilience based principles will be operationalized in guidelines for the management of trauma patients, their caregivers and in routine nursing and trauma team care from the emergency to the ward, and discharge, through to outpatient care. it is hypothesized that this will improve the psychological recovery of patients at risk of developing ptsd after a traumatic injury. in addition, early screening and intervention for increased risk of ptsd will be implemented one month after the trauma. it is hypothesized that such trauma informed psychological management, early screening and expert treatment using prolonged exposure will reduce hospital stays, functional disability, as well as longer-term psychiatric morbidity, including substance abuse.

the study is a longitudinal interventional study, with a control group who have treatment for their trauma with no guidelines for psychological management, staff training, patient and family intervention/education. in the intervention group, who will have all of the above, participants will be stratified according to risk factors for ptsd and randomized 1:1 in "low risk" and "at risk" groups-those who will have a prolonged exposure intervention and those who will not.

Eligibility criteria:
inclusion criteria: * undergone severe physical trauma within the last 3 days * an abbreviated injury severity score of 1-3 exclusion criteria: * 14 years of age or younger * an inability to communicate sufficiently in english * a diagnosis of psychosis, mental retardation and/or autism

Keywords: early intervention prevention risk factors exposure therapy psychoeducation
postoperative gastrointestinal dysfunction after high risk surgery

Conditions: Gastrointestinal Dysfunction; Surgery; Postoperative Complications

Summary: this study aims to find out the role of plasma i-fabp level, sofa score, fluid balance, and vasopressor dose in predicting gastrointestinal dysfunction in high-risk postoperative patients treated in icu

this is a prospective cohort study to find out the role of plasma i-fabp level, sofa score, fluid balance, and vasopressor dose in predicting gastrointestinal dysfunction in high-risk postoperative patients treated in icu. the characteristics of patients who meet the eligibility criteria were obtained. blood sampling during admission is done for i-fabp level measurement and will be repeated after 24 hours. blood sample which is not directly processed will be stored in refrigerator under 6-8c temperature. evaluation of acute gastrointestinal injury signs and symptoms is done. the re-evaluation is performed every day. if patients experiencing agi signs and symptoms, monitoring and treatment based on condition are done. routine follow-up is continued during hospitalisation in icu. after all sample are collected, i-fabp level is assessed quantitatively using elisa.

Eligibility criteria:
inclusion criteria: * high-risk postoperative patients * patients treated in intensive care unit of emergency department or surgery unit in cipto mangunkusumo general hospital * age \>18 years old * patients or family give written consent to follow the study exclusion criteria: * patients with late trimester-pregnancy when admitted to icu * patients undergo cardiac surgery * patients with gastrointestinal disorders requiring routine therapy * patients undergo surgery involving bowels * patients undergo surgical treatment for burn * patients treated in icu \>24 hours before surgery drop-out criteria * unable to obtain blood sampling for i-fabp level examination in icu * unable to perform acute gastrointestinal injury examination in icu * patients died within \<24 hours treatment in icu * patients or family decide to quit from the study

Keywords: gastrointestinal dysfunction high risk surgery postoperative
a mobile application for female athletes with pelvic floor dysfunctions (actitud2.0)

Conditions: Pelvic Floor Disorders

Summary: pelvic floor dysfunctions (pfd) are especially prevalent among females. as conservative management, strengthening pelvic floor (pf) musculature under health supervision, regard an important research line. however, embarrassment of female athletes limits healthcare demands. new technologies could facilitate an autonomous but supervised tele-rehabilitation programs. this study will evaluate the effects of a 12-weeks program with exercises focused on pf awareness and strengthening by using a mobile application supervised by physiotherapists, with or without intracavitary biofeedback, on the pf anatomical and functional characteristics, symptomatology and sports performance of female athletes with pfd. to this end, 105 female athletes with self-reported pfd who train and compete in sport in spain will be recruited and randomly distributed in three groups of the experimental study. during 12 weeks, all participants will use the mobile application (named actitud): the control group (cg) will have access to information about pf and direct communication with healthcare team; experimental group 1 (eg1) will have access to the same information and communication, and will perform a the exercise program for pf; the experimental group 2 (eg2) will be similar to eg1, but they will use an intravaginal biofeedback device during exercises to receive information about their intra-vaginal pressure. before and after these 12 weeks, anatomical and functional pf characteristics, pf symptoms and sports performance of all participants will be evaluated. as additional outcome, the compliance of the athletes from experimental groups to complete the training program will be registered (in %).

female athletes from eg1 and eg2 will complete the exercise program for pf three times per week, during 12 weeks. each session will last about 20 minutes and exercises will be modified every two weeks to meet the principle of training progression and avoid athletes become bored.

Eligibility criteria:
inclusion criteria: * to train and compete in any sport. * to have a self-reported pelvic floor disorder (urinary incontinence, anorectal incontinence, sexual dysfunction or chronic pelvic pain). exclusion criteria: * to have recurrent infections of urinary tract during the last three months. * to be receiving physiotherapy treatment due to any pelvic floor disorder at the moment of the start of the study. * to have been pregnant during the year prior to the start of the study.

Keywords: female athletes e-health exercises
remote monitoring of respiratory health

Conditions: Chronic Respiratory Disease; Asthma; Copd

Summary: recently, interest in ways to monitor and care for patients remotely has significantly increased due to concerns for infection control as well as a way to increase access to regular clinic visits that may be limited for socioeconomic and geographic reasons. however, remote care can be limited by a lack of objective data to help guide clinical care. with respect to respiratory disease, caring for patients remotely may be enhanced by the ability of patients to monitor at home such things as vital signs, lung sounds, and lung function by spirometry. enhanced methods to follow symptoms and track medication compliance may also be beneficial. these enhancements could improve care and quality of life both for persons with acute respiratory illnesses and those with chronic respiratory disease (such as asthma or copd). the purpose of this study is to develop and study methods for patients to monitor their respiratory health at home and make that data available to medical providers to improve their care.


Eligibility criteria:
inclusion criteria: * age 1 month or older with a diagnosis of chronic respiratory disease (ex. asthma, copd), an acute respiratory illness or a healthy volunteer * able to consent or assent with parental consent exclusion criteria: * people who do not consent * significant cognitive impairment * non-english speaking

Keywords: digital health mobile monitoring