Kornimate/medical-research-clean huggingface dataset:
comparison of post-operative pain occurrence after single visit root canal treatment

Conditions: Symptomatic Irreversible Pulpitis

Summary: the goal of this clinical trial is to compare the post-operative pain occurrence after single visit root canal treatment using two niti rotary files. the main question it aims to answer is: • does an instrument design and instrumentation technique could affect postoperative pain incidence and intensity? researchers will use protaper universal rotary system or m-pro rotary system for root canal preparation and compared postoperative pain intensity. participants will receive single visit endodontic treatment using either protaper or mpro systems for root canal preparation. participants will record pain intensity at 24 hours and 7 days post-operative. analgesics will be prescribed for the patients in need.

the main cause of patient fear is expecting pain during root canal treatment. it is considered a major concern for dentists as well. during root canal preparation, periapical extrusion of pulpal tissue remnants, microorganisms or dentin chips may be one of the causes of postoperative pain. depending on the fact that, instrument design and instrumentation techniques have an impact on the amount of extruded debris apically, many studies proved the ability of some rotary systems to reduce debris extrusion, permitting to achieve less pain sensation. therefore, the present clinical study aims to compare the postoperative pain intensity in molars with symptomatic irreversible pulpitis after single endodontic treatment visit using a full-sequence rotary ni-ti system either protaper or mpro systems eighty patients with symptomatic irreversible pulpitis in mandibular first molars will be assigned into two groups. in group a (n=40): root canal preparation will be performed in single visit using protaper universal system and in group b (n=40): root canal preparation will be performed in single visit using m-pro rotary system. pain intensity will be recorded by the patient using numerical rating scale (nrs) at 24 hours and 7 days postoperative. analgesics will be prescribed for the patients in case of need.

Eligibility criteria:
inclusion criteria: * patient's diagnosis is symptomatic irreversible pulpitis in mandibular first molar. * males and females patients in a good health. * aged from 25 to 45 years old. * pulp vitality is confirmed with cold pulp test and an electric pulp test. exclusion criteria: * pregnant females. * patients complaining from pain in more than one molar on the same side. * patients whose teeth react positively to percussion test. * patients who receive analgesics 12 hours before the start of the root canal treatment. * teeth having grade 2 or 3 mobility. * presence of periapical radiolucency or teeth with extra oral or intraoral sinus tract or fistula.

Keywords: post-operative pain protaper m-pro single visit
association of plasma melatonin levels with delirium

Conditions: Postoperative Delirium

Summary: delirium is common complications in postoperative critically ill patients. however the mechanism of postoperative delirium is not well understood.the investigators designed a prospective observational study to investigate the association of perioperative plasma melatonin levels with postoperative delirium and general anesthesia. the investigators included 33 patients required intensive care more than 48 hours after sevoflurane anesthesia in an academic tertiary care hospital. the investigators measured plasma melatonin levels 4 times and assessed postoperative delirium using confusion assessment method for the intensive care unit (cam-icu).

delirium is common complications in postoperative critically ill patients. although the mechanism of postoperative delirium is not well understood, there are several studies to report alternation of plasma melatonin levels after general anesthesia and suggest the link between delirium and abnormal tryptophan-serotonin-melatonin metabolism. however, there are few studies to assess the association of perioperative plasma melatonin levels with postoperative delirium and/or general anesthetics. the investigators designed a prospective observational study to investigate the association of perioperative plasma melatonin levels with postoperative delirium and general anesthesia. the investigators included 33 patients required intensive care more than 48 hours after sevoflurane anesthesia in an academic tertiary care hospital. the investigators measured plasma melatonin levels and assessed postoperative delirium using confusion assessment method for the intensive care unit (cam-icu). the investigators compared perioperative plasma melatonin levels between patients with and without delirium, and assessed associations of patients' demographics and anesthesia with plasma melatonin levels.

Eligibility criteria:
inclusion criteria: * patients over 20 years of age who had undergone elective surgery with sevoflurane anesthesia and were expected to require postoperative intensive care for more than 48 hours exclusion criteria: * emergency surgery, history of psychosis and drug/alcohol abuse, and vision or hearing impairment

Keywords: postoperative delirium melatonin sevoflurane
telemedicine interventions for obstructive sleep apnea (osa)

Conditions: Sleep Apnea

Summary: this project is investigating whether both moderate-intensity physical activity and dietary weight loss will independently reduce sleep apnea symptoms and improve quality of life.

background/rationale: obstructive sleep apnea/hypopnea (osah) is a common chronic disease that is associated with daytime sleepiness, impaired health-related quality of life (qol), and increased risk of hypertension and cardiovascular disease. the most common treatment is continuous positive airway pressure (cpap), although adherence to cpap is poor in more than one-third of patients. weight loss can clearly lessen the severity of osah, but although short-term dietary weight loss can often be achieved it is difficult to maintain. regular aerobic exercise is associated with a lower prevalence of osah in observational studies after adjustment for body habitus, and in two small clinical trials moderate exercise was associated with a substantial decrease in osah severity despite little or no weight loss. demonstrating that dietary weight loss and moderate physical activity, promoted in the home setting, independently improve osah severity will have a major impact on the therapeutic approach to osah, a disease that is highly prevalent in the va population. objective: the investigators hypothesize that both moderate-intensity physical activity and dietary weight loss will independently reduce osah severity and improve qol. methods: the proposed study is a randomized clinical trial designed to test the independent effects of the physical activity and diet interventions, with an attention control intervention for subjects not assigned to either active intervention. subjects will be male and female veterans with a bmi over 24 kg/m2, with a physician diagnosis of osah and apnea-hypopnea index (ahi) \>10/hr. the interventions will last six months.

Eligibility criteria:
inclusion criteria: * physician diagnosis of sleep apnea * apnea-hypopnea index \>10/hr * bmi over 24 kg/m2 exclusion criteria: * angina pectoris * history of myocardial infarction within 6 months

Keywords: sleep apnea sleep symptoms quality of life
effects of arom digest slim on metabolic profile and food behaviour in overweight persons

Conditions: Metabolic Syndrome

Summary: the present study aims to evaluate the efficacy of arom digest slim in facilitating weight reduction along with a series of minimal nutritional interventions.

arom digest slim is a blend of fish collagen and essential oils. it will be administered in a group of overweight females wich also undertake minimal nutritional changes. the group will be compared with a group following only minimal nutritional changes.

Eligibility criteria:
inclusion criteria: * females 18 to 60 years old exclusion criteria: * cardiovascular, psychiatric and neurologic chronic conditions and medication * acute conditions * patients with hypersensitivity to any components of the product

Keywords: collagen volatile oils metabolic syndrome insulin resistance
the impact of a patient decision aid on treatment choices for patients with an unexpected malignant colorectal polyp

Conditions: Shared Decision Making; Colonic Polyp; Decision Aids; Rectal Polyp; Colorectal Polyp; Colorectal Cancer

Summary: management of unexpected malignant colorectal polyps removed endoscopically can be challenging due to the risk of residual tumor and lymphatic spread. international studies have shown that in patients choosing surgical management instead of watchful waiting, 54-82% of bowel resections are without evidence of residual tumor or lymphatic spread. as surgical management entails risks of complications and watchful waiting management entails risks of residual disease or recurrence, a clinical dilemma arises when choosing a management strategy. shared decision making (sdm) is a concept that can be used in preference sensitive decision making to facilitate patient involvement, empowerment, and active participation in the decision making process. this is a clinical multicenter, non-randomized, interventional phase ii study involving danish surgical departments planned to commence in the first quarter of 2024. the aim of the study is to examine whether shared decision making and using a patient decision aid (ptda) in consultations affects patients' choice of management compared with historical data. the secondary aim is to investigate patient reported experience measures (prems) and patient reported outcome measures (proms) using questionnaire feedback directly from the patients.


Eligibility criteria:
inclusion criteria: * histopathologically verified malignant colorectal polyp removed endoscopically and ct-scan (and mri if the malignant polyp was situated in the rectum) shows n0, m0 disease. exclusion criteria: * inability to provide informed consent * inoperable due to comorbidity * known residual tumor left in situ after local resection, \>n0 or \>m0

Keywords: non-randomized trial malignant colorectal polyp patient decision aid shared decision making
observing people with desmoid-type fibromatosis

Conditions: Desmoid Fibromatosis

Summary: the purpose of this study is to closely observe people with desmoid-type fibromatosis over 1 months.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of desmoid fibromatosis, either new or newly recurrent. both patients with sporadic and fap-associated disease will be eligible for inclusion. patients with clinical diagnosis of desmoid (as assessed by msk physician) but without pathologic diagnosis may be enrolled on the study to facilitate acquisition of appropriately protocoled baseline scans and allow for biospecimen collection; these patients will be replaced for purposes of analysis if pathology does not confirm clinical diagnosis. * at least 18 years of age. * able to undergo cross-sectional imaging by either mri or ct with intravenous contrast * disease detectable on cross-sectional imaging with target lesion measuring \>/= 1 cm * eligible for management by active observation as assessed by primary msk care provider * willing and able to sign an informed consent document exclusion criteria: * symptomatic desmoid fibromatosis requiring narcotic pain control, resulting in intestinal fistulization, or requiring inpatient admission during the 3 months prior to enrollment * patients with intraabdominal desmoids greater than 7cm in diameter or localized within 1cm of the central mesenteric vessels and those with tumors in the head and neck * kps performance status \</= 70 if performance status is limited due to tumor. patients with low kps performance status related to co-morbidities but without symptoms related to the tumor will be eligible for enrollment. * age less than 18 years old * strict contraindication for both cross-sectional mri and ct imaging with intravenous contrast (e.g., as per standard institutional protocols regarding renal insufficiency or mri incompatible implanted devices; patients requiring pre-medication to prevent contrast reactions will be eligible for study) * unable to grant reliable informed consent * ongoing systemic treatment for desmoid fibromatosis

Keywords: desmoid-type fibromatosis desmoid fibromatosis desmoid fibromatosis 20-026 memorial sloan kettering cancer center
islet transplantation for patients with type 1 diabetes

Conditions: Diabetes Mellitus, Type 1

Summary: this protocol will test whether type 1 diabetes (t1dm) can be reversed in patients with stable renal allografts by islet transplantation.

we will test whether pancreatic islets isolated from cadaveric human donor pancreata can be transplanted into the portal vein of patients with t1dm who have stable renal allografts to achieve insulin independence for the recipient. the protocol will employ a defined islet isolation procedure, percutaneous islet infusion into the recipient's portal vein via an intra-portal catheter, tight glycemic control during the peri-transplant period, and an immunosuppressive protocol that avoids glucocorticoids.

Eligibility criteria:
* patients with type 1 diabetes with stable renal allografts

Keywords: diabetes autoimmunity
study to evaluate the safety and efficacy of ctp-543 in adults with moderate to severe alopecia areata

Conditions: Alopecia Areata

Summary: this study will evaluate the safety and efficacy of ctp-543 on hair loss in adults with chronic, moderate to severe alopecia areata.

this is a double-blind, randomized, placebo-controlled multi-center study consisting of 3 cohorts to assess the safety and efficacy of ctp-543. each cohort will be initiated sequentially in ascending dose order. participants will be randomized to either an active dose of ctp-543 or placebo for a 24-week treatment period.

Eligibility criteria:
inclusion criteria: * definitive diagnosis of alopecia areata with a current episode lasting at least 6 months and not exceeding 10 years at the time of screening. total disease duration greater than 10 years is permitted. * at least 50% scalp hair loss, as defined by a severity of alopecia tool (salt) score ≥50, at screening and baseline. * clinical lab results within the normal range exclusion criteria: * active scalp inflammation, psoriasis, or seborrheic dermatitis requiring topical treatment to the scalp, significant trauma to the scalp, or untreated actinic keratosis on the scalp. * treatment with systemic immunosuppressive medications or biologics. * vaccination with herpes zoster vaccine or any live virus within 6 weeks of screening or during the study
study of nasonex in the relief of nasal congestion in patients with seasonal allergic rhinitis (study p05529)

Conditions: Allergic Rhinitis

Summary: this study seeks to prospectively demonstrate that nasonex is better than placebo in relieving nasal congestion in patients with seasonal allergic rhinitis.


Eligibility criteria:
inclusion criteria: * a subject must be 12 years of age or older, of either sex, and of any race. * a subject must have at least a 2-year history of sar which exacerbates during the study season. * a subject must have a positive skin prick test response to an appropriate seasonal allergen at visit 1. * a subject must be clinically symptomatic at the screening and baseline visits. exclusion criteria: * a subject with a history of severe local reaction(s) or anaphylaxis to skin testing. * a subject who has had an upper respiratory tract or sinus infection that required antibiotic therapy without at least a 14-day washout prior to the screening visit, or who has had a viral upper respiratory infection within 7 days prior to the screening visit. * a subject who has used any drug in an investigational protocol in the 30 days prior to the screening visit. * a subject who is participating in any other clinical study. * a subject who is part of the staff personnel directly involved with this study. * a subject who is a family member (parent, spouse, or sibling) of the investigational study staff. * a female subject who is breast-feeding, pregnant, or intends to become pregnant. * a subject previously randomized into this study. * a subject who has a family member (parent, spouse, or sibling) currently enrolled in this study.
olfaction and bipolar disoder

Conditions: Bipolar Disorder

Summary: to compare olfactory performance between patients with bd and hc and correlate their performances to neuroimaging data


Eligibility criteria:
inclusion criteria: * patients with bd and hc * fluent in french * having a public health insurance * not being on tutorship exclusion criteria: * family history of bipolar disorder for controls * alcohol dependence
bbti vs psr in musculoskeletal orofacial pain adults

Conditions: Myofascial Pain; Myalgia

Summary: this clinical study aims to compare the efficacy of two brief psychological interventions: brief behavioral therapy for insomnia (bbit) and physical self-regulation or (psr) delivered over telehealth for the management of chronic musculoskeletal orofacial pain conditions (local myalgia, myofascial pain, centrally mediated myalgia) in a tertiary orofacial pain clinic. it is hypothesized that both interventions will produce beneficial changes and exploratory analysis will aim to establish which intervention -if any- is better for each specific outcome.

new patients who come into the orofacial pain clinic are evaluated by a dental resident and given an orofacial pain diagnosis. if this primary diagnosis involves masticatory myofascial pain, local myalgia, or centrally-mediated myalgia, and if patients self-report poor sleep, they will be introduced to the study. an initial evaluation for psr and bbti will be scheduled over telehealth. if willing and eligible to participate, at the end of this first evaluation, they will be provided with an informed consent form and be randomly assigned to three sessions of psr or three sessions of bbti. after providing an e-consent, they will be sent a questionnaire battery on redcap to assess their outcomes at pre-intervention. a redcap daily questionnaire will be sent every day (morning and evening) starting one week before session 1 of the intervention, until two weeks after the last session. moreover, to a small group of patients randomly selected, an actigraphy watch will be mailed. two weeks after the last session of the intervention, a redcap questionnaire will be sent to assess their outcomes at post-intervention. as per the current clinical protocol, all participants will be offered both interventions; only data from the first intervention will be utilized for the current study. all psr and bbti sessions will be conducted via telehealth using a hipaa-compliant zoom account.

Eligibility criteria:
inclusion criteria: * present with a score on insomnia severity index \> 15 * have a primary diagnosis of chronic (onset more than 3 months before) msk pain (myofascial pain and/or local myalgia and/or centrally mediated myalgia) from a board-certified orofacial pain specialist at uk orofacial pain clinic * maintain a stable medication regime in previous month and during the intervention * older than 18 years old * able to understand english * willing to participate to telehealth intervention * have internet access and an email address * present with total stop bang score \< 5 exclusion criteria: * less than 18 years old * unable to provide informed consent

Keywords: local myalgia centrally-mediated myalgia masticatory pain sleep insomnia behavioral therapy self-regulation depression anxiety fatigue
exercise training versus best medical treatment only in peripheral artery disease

Conditions: Peripheral Artery Disease

Summary: the aim of the investigators' study is to analyze the value of supervised exercise training combined with medical therapy versus best medical treatment only with respect to quality of life. furthermore, the investigators aim to evaluate the effect of supervised exercise training on microcirculation, peripheral endothelial progenitor cells as well as on future major cardiovascular adverse events.

peripheral arterial disease (pad) affects 7 - 12% of the population aged over 50 years. over an age of 60 years up to 20% are suffering from pad in western societies. both, percutaneous transluminal angioplasty (pta) and surgical repair (bypass graft, thrombectomy) are well established procedures to improve peripheral arterial perfusion. however, long-term results remain disappointing: low patency-rates are associated with clinical deterioration. moreover, clinical outcome is often limited by early major cardiovascular adverse events (myocardial infarction, stroke). therefore, medical therapy plays a major role in the management of pad patients: antihypertensive medication, statins as well as an adequate diabetes therapy are important cornerstones in the therapeutical management of pad. prior studies have shown that regular supervised exercise training can improve patients´walking impairment. we hypothesize that regular supervised exercise training significantly improves quality of life and decreases the occurence of future major cardiovascular adverse events. we further aim to investigate the effect of exercise training on peripheral microcirculation and endothelial progenitor cells.

Eligibility criteria:
inclusion criteria: * peripheral artery disease with intermittent claudication (rutherford 2-3) * exercise tolerance * ankle brachial index \< 0,9 * ability to life independently at home exclusion criteria: * no pad * asymptomatic pad * ischemic rest pain * exercise tolerance limited by other factors than claudication (e.g., coronary artery disease, dyspnoea, poorly controlled blood pressure, any kind of restriction of the musculoskeletal system which might have an influence on the efficiency of exercise training)

Keywords: peripheral artery disease quality of life outcome endothelial progenitor cells microcirculation
five-year outcome of laparoscopic gastric sleeve

Conditions: Bariatric Surgeries; Metabolic Surgery

Summary: the aim of this study is to evaluate the long-term (5-year follow-up) results of laparoscopic gastric sleeve (lgs) in terms of weight loss and obesity related comorbidities, as well as the risk factors associated with postoperative nutritional deficiencies.

the consecutive patients who undergo lgs for the treatment of morbid obesity at tartu university hospital are followed prospectively in cohort study. the outpatient hospital follow-up visits are conducted at 3 months, 1 year and 5 years postoperatively.

Eligibility criteria:
inclusion criteria: * the criteria for bariatric surgery: bmi of \>40, or \>35 with certain obesity related comorbidities exclusion criteria: * patients who did not fill the inclusion criteria

Keywords: gastric sleeve