Kornimate/medical-research-clean huggingface dataset:
gonadal steroid manipulation and personality characteristics: association with mood fluctuations and in vitro fertilization (ivf) outcomes

Conditions: Mood Disorders

Summary: the current study's primary aim is to investigate the association between neuroendocrine fluctuations and mood disorders by monitoring mood states over distinct hormonal phases during in-vitro-fertilization (ivf) treatment. the secondary goal of this study is to explore psychological profiles and coping mechanisms of women undergoing ivf, and to identify the ones that are associated with successful psychological adaptation to the process and a successful biological outcome.


Eligibility criteria:
inclusion criteria: 1. admitted for their first or second ivf cycle; 2. demonstrated sufficient communication skills and level of understanding in the hebrew language; 3. signed an informed consent; 4. were under the age of 42; 5. were not suffering from endometriosis or male factor in patients who underwent testicular sperm extraction (tese); 6. were not under psychotherapeutic or psychopharmacological treatment. the accepted indications for the ivf included a female factor, male factor or unexplained infertility. exclusion criteria: 1. all others.

Keywords: women admitted to the in vitro fertilization unit
the acute effects of eucaloric and hypocaloric carbohydrate restriction on liver fat content and metabolism in obese individuals

Conditions: NAFLD; Overweight and Obesity; Metabolic Syndrome; Diabetes

Summary: the primary aim of this study is to investigate the acute changes in liver fat content in response to a fixed carbohydrate restriction (i.e. intake of 60g/day or 70g/day for women and men, respectively) in individuals with obesity. this will be performed both as 2 days of very low calorie diet (500 and 600 kcal/day for women and men, respectively) and 2 days of eucaloric low carbohydrate diet.


Eligibility criteria:
inclusion criteria: * men (30-75 years) and postmenopausal women 45-75 years old * hba1c \<48 mmol/mol without antidiabetic treatment * obese (bmi 27-40 kg/m2) * non smokers exclusion criteria: * anemia (hemoglobin \<8 mmol/l for men and \<7 mmol/l for women) * tsh outside reference range * medication known to influence glucose metabolism or appetite regulation * contraindications for mr-scan: abdominal height exceed limitations of the mr-scanner, pacemaker or other electronic device implanted, implanted metal devices, severe claustrophobia * food allergies (including lactose and gluten intolerance), vegetarian/vegan diet or following specific dietary plans * alcohol consumptions \>84/168 g/week (women/men) * strenuous activity level \> 120 minutes per week * \>5 kg weight loss within the last three months or previous bariatric surgery * high risk of fibrosis of the liver (estimated by fib4 score \> 3,25)
phast: physical activity in substitution therapy

Conditions: Substance-related Disorders

Summary: the aim is to examine the effect of exercise (ex) training on individuals currently receiving st - either opiate replacement therapy (ort) or heroin-assisted treatment (hat) - for their opiate dependence. main outcome variables will be: cardiovascular fitness; consumption of substances (e.g. "street heroin", cocaine, cannabis, alcohol, cigarettes) other than prescribed st or other prescribed medications; substance craving; blood pressure; lung function; resting pulse; social interaction; self-control capacity; objective and subjective sleep; cortisol levels; quality adjusted life years (qalys); depression; mood. covariates are current substitution dose and psychiatric diagnoses.

the investigators aim is to carry out a randomized controlled trial comparing exercise training group and a control group of patients receiving substitution therapy (st). the specific goals of the study are: 1. to understand the exercise preferences, barriers to participation, motivation, experiences and attitudes regarding exercise training in patients under st. 2. to examine whether a 12-week exercise programme affects the mental health, subjective and objective sleep, quality of life, self-control capacity, substance craving, hair cortisol levels, secondary consumption, cardiovascular fitness, blood pressure, lung function, resting pulse, and social interaction in patients receiving st. 3. to compare the effects of the ex and control conditions on the above-mentioned outcome variables. 4. to examine to what degree the covariates of heroin substitution dose and psychiatric comorbidities affect outcome variables. 5. to explore to what extent objective variables (cardiovascular fitness, pulse, blood pressure, lung function, cortisol, objective sleep-eeg-parameters) and subjective-psychological dimensions (subjective sleep, social interaction, symptoms of depression and anxiety, self-control, substance craving) are interrelated.

Eligibility criteria:
inclusion criteria: patient at the ambulanter dienst sucht or janus clinics in basel town (bs); currently under substitution therapy exclusion criteria: declared unfit to participate by clinic personnel due to physical disability or severe psychological disturbance or cognitive impairment

Keywords: craving
response to cardiac resynchronization therapy of previously right ventricular paced heart failure patients

Conditions: Heart Failure; Pacing Induced Dyssynchrony

Summary: the present proposal is designed to investigate the response to crt in patients who were previously paced from the right ventricle (rv). the negative physiologic and structural changes associated with chronic rv pacing are well documented, but patient response following upgrade to crt after chronic rv pacing has not been well characterized in a large cohort.

the rv apex has historically been used as the site for ventricular pacing in cases of sinus node dysfunction or atrioventricular block because of its relatively accessible location for lead implantation. initial studies showed rv pacing improved symptoms, exercise capacity, quality of life, and survival in these patients.11-13 however, more recent studies have illustrated that chronic rv pacing may actually impair lv systolic function and increase the risks of heart failure, hospitalization, and death in some patients. the primary hypothesis is that patients upgraded to crt from a rv pacemaker respond better than those receiving crt as a first time device. to test this hypothesis the investigators will compare changes in cardiac size and function, and hospitalization and survival rates between the two patient groups. the second hypothesis will investigate whether changes in septal dyssynchrony are correlated with changes in ejection fraction in previously rv paced patients. the investigators believe that the patients with the most improvement in septal dyssynchrony due to rv pacing will see the greatest improvement in lv function following upgrade to crt. a significant correlation between change in im-s and change in ef will support the hypothesis.

Eligibility criteria:
inclusion criteria: * received a crt device between 2003 and 2009 at united heart \& vascular clinic * qrs duration \> 120 msec * pre-crt ejection fraction =\< 35% exclusion criteria:

Keywords: cardiac resynchronization therapy heart failure mortality
safty and feasibility study of therapeutic cooling in acute ischemic stroke (coolaid øresund)

Conditions: Cerebral Infarction

Summary: this study is designed to investigate the safty and feasibility of therapeutic hypothermia in acute stroke patients. soon after arrival in the stroke unit patients are randomized to either hypothermia in the intensive care unit (icu) or standard treatment in the stroke ward. patients randomized to therapeutic hypothermia are analgo-sedated and cooled to at temperature of 33 degrees for a period of 24 hours.

ischemic stroke remains a diagnosis with limited treatment opportunities and a treatment with the ability to target patients outside the normal treatment window is wanted. therapeutic hypothermia (th) treatment has long been recognised as a treatment of patients with global ischemia following caridac arrest. this trial is designed to address the safty and feasibility of th in acute stroke patients. patients arriving in our stroke ward are observed for 3 hours. only non-remitting patients are allowed into the trial. patients are randomized to either therapeutic hypothermia with endovascular catheter + nasopharyngeal induction or endovascular catheter alone in the intensive care unit (icu) (in copenhagen, denmark) or intravenous cold saline infusion followed by surface cooling (in malmø, sweden)versus standard treatment in a stoke unit. patients brought to the icu are sedated and mechanically ventilated. therapeutic hypothermia is induced with a endovascular catether and a nasopharyngeal catheter. body temperature is lowered to 33 degrees and sustained for a period of 24 hours.

Eligibility criteria:
inclusion criteria: * national institute of health stroke scale (nihss) score on admission between 5 and 18 * inclusion within 24 hours after stroke onset * diagnosis of ischemic stroke verified by mri, ct or ctp adjudicated by including physician * informed consent from patient or proxy exclusion criteria: * modified ranking scale (mrs)\>2 indicating significant disability before onset of stroke * mri or ct evidence for massive ischemic damage (\>50% middle cerebral artery (mca) territory) * severe concomitant diseases such as heart failure, chronic obstructive lung disease or known cancer * presently on anticoagulation treatment * no informed consent from patient or proxy

Keywords: hypothermia, induced
red cell lysis buffer application versus conventional sample processing in eus-fnb

Conditions: Pancreatic Diseases

Summary: the goal of this clinical trial is to evaluate the application of red cell lysis buffer (rclb) versus conventional sample processing in endoscopic ultrasonography (eus)-guided biopsy for solid pancreatic lesions. the main questions it aims to answer are: whether the application of red cell lysis buffer improves histological tissue quality by decreasing blood contamination. participants with solid pancreatic lesions who needs histological diagnosis will receive eus-guided biopsy. the obtained specimens will be processed by rclb and conventional formalin solution. researchers will compare the blood contamination score of specimens in rclb group with the conventional group see if the blood contamination can be improved.


Eligibility criteria:
inclusion criteria: 18 to 80 years old; solid pancreatic lesions confirmed by clinical and ct/mri/ pet imaging. signed written informed consent exclusion criteria: contraindication of eus-guide procedure or technical infeasibility (e.g.,coagulation disorder, anatomical changes, large vessels along the puncture path) pregnant patient is enrolled in any other clinical protocol or investigational trial

Keywords: eus-fnb sample processing solid pancreatic lesion
efficacy and safety of xylitol nasal irrigation after functional endoscopic sinus surgery

Conditions: Chronic Rhinosinusitis; Postoperative Care

Summary: investigators tried to evaluate the efficacy and safety of xylitol nasal irrigation as an adjuvant therapy after fess, particularly the influence of nasal irrigation on eustachian tube function.

in this study, patients with chronic rhinosinusitis who received fess were recruited and randomly assigned to 2 groups at one month post-surgery. patients in the xylitol group received 400ml of 5% xylitol nasal irrigation daily for 2 months, and those in the normal saline (ns) group received 400ml of ns nasal irrigation daily for 2 months. before fess as well as before and after nasal irrigation, sino-nasal symptoms were assessed by a 22-item sino-nasal outcome test questionnaire and patients received endoscopic examination, nasal function tests, cytokine measurement of nasal irrigant, and bacterial culture from the middle meatus. the safety of nasal irrigation was assessed by self-reported adverse events, blood test, eustachian tube dysfunction patient questionnaire and eustachian tube function test. this study tried to evaluate the efficacy and safety of xylitol nasal irrigation as an adjuvant therapy after fess, particularly the influence of nasal irrigation on eustachian tube function.

Eligibility criteria:
inclusion criteria: 1. patients with chronic rhinosinusitis who failed medical treatment 2. patients underwent bilateral primary functional endoscopic sinus surgery. exclusion criteria: 1. patients with a history of immunodeficiency 2. patients with a history of sinus surgery 3. patients who receiving antibiotic treatment within a week before functional endoscopic sinus surgery 4. patients with a pathological diagnosis of fungal sinusitis 5. patients with a pathological diagnosis of sinonasal tumor
compex use with delayed onset muscle soreness: a comparison to other methods

Conditions: Focus of Study is to Determine Efficacy of Compex

Summary: the purpose of this research study is to determine if the application of ice, control group, or a muscle stimulation program from the compex® series can help reduce or eliminate delayed muscle soreness from performing leg extension and flexion. individuals will complete a health history questionnaire to determine if they qualify for this study. we will measure your leg girth with a measuring tape and take a pain measurement of your hamstrings by using a spring to press down on your leg. individuals will then warm-up on a bike without resistance for 5 minutes followed by 10 regular leg extension and flexion exercises. individuals will then perform 6 sets of 10 leg extension and flexion exercises on a biodex machine (similar to leg curl machines in the gym). individuals will perform each set to the maximum effort of their capables. after each set of 10 individuals will have a 2 minute rest. we will ask you to rank your leg soreness on a scale from 1-10. individuals will then be assigned to a modality of either ice, control group or compex. individuals will perform the modality (ice, control, compex) we assign you to until you are no longer sore. over the next five days individuals will return to measure their level of soreness, leg girth and pain pressure. this study will examine the following hypotheses: h1: there will be no difference in pressure pain threshold after using the compex compared to other groups. h2: there will be no difference in perceived soreness after using the compex compared to other groups. h3: there will be no difference in muscular strength after using the compex compared to other groups. h4: there will be no difference in active range of motion after using the compex compared to other groups.


Eligibility criteria:
inclusion criteria: * the studied population will be composed of 45 physically active college students between the ages of 18-30 years old. * inclusionary criteria will be participation in a physical activity as defined by the acsm, which can be a mixture of moderate (i.e., sufficient to raise the heart rate and begin to sweat) and vigorous (i.e., breathing hard and fast with a rapidly rising heart rate) intensity aerobic activity and muscle strengthening (i.e., weights lifted to the point where anther repetition cannot be completed without help) activities two or more time per week (acsm, 2011.) exclusion criteria: * exclusionary criteria will be surgery within the last six months requiring immobilization for more than four weeks, discomfort performing intense physical activity, diseases like muscular dystrophy that predispose muscular damage beyond reasonable levels resulting from physical activity, and current injury of the knees or hips.

Keywords: compex, ice
postoperative lactate and atrial fibrillation after cabg

Conditions: Coronary Artery Disease; Atrial Fibrillation

Summary: postoperative atrial fibrillation (poaf) is associated with increased mortality and morbidity in patients undergoing isolated coronary artery bypass grafting (cabg). it has been estimated that 5-40% of cabg patients experience poaf. advanced age, p wave abnormalities, left atrial dilation, emergency surgery, low left ventricle ejection fraction, low glomerular filtration rate and chronic obstructive pulmonary disease have been reported in the etiology. predicting which patients would experience poaf following cabg is important since it would allow physicians to apply more focused prophylactic measures. lactate is the final product of anaerobic glycolysis. serum lactate level are increased in case of inadequate oxygen delivery to tissues. the investigators aim to assess whether serum lactate levels measured early in the postoperative period could be used as a predictive marker of poaf in adults undergoing isolated cabg.


Eligibility criteria:
inclusion criteria: * undergoing isolated cabg * age \>18 years exclusion criteria: * age \<18 years * pregnancy * history of paroxysmal atrial fibrillation prior to surgery * undergoing concomitant procedures (e.g., cabg + valve surgery) * any preoperative cardiac rhythm other than normal sinus rhythm * more than mild cardiac valve stenosis or insufficiency
a worldwide antihistamine-refractory chronic urticaria patient evaluation in latin america and canada (aware-lacan)

Conditions: Chronic Urticaria

Summary: this is a non-interventional, multi-country, latin american study utilizing a prospective single-cohort design. eligible cu patients will be enrolled in the study and will be followed for 24 months (± 6 weeks). in accordance with the observational nature of the study, there will be no interventions or interference with the routine care of the patient which will be based solely on the clinical judgment of the treating physician. however, with respect to the frequency and schedule of assessments, the schedule included in table 7-1 will be recommended. the selection of the treatment for cu will be clearly separated from the decision to include the patient in the study, and will be made at the discretion of the treating physician in accordance with standard medical practice, the investigator's clinical judgment, and global urticarial guidelines. in order to prevent selection bias, investigators should offer enrollment to all consecutive patients meeting study criteria, likely to be available for the full duration of the follow-up period of 24 months, and willing to participate in the study. the overall objective of the study is to evaluate in real-life the cu disease burden, the current treatment patterns and the use of health care resources in patients refractory to h1-antihistamine treatment


Eligibility criteria:
inclusion criteria: men or women at least 18 years of age or older. patient has medically confirmed diagnosis of chronic urticaria present for more than 2 months. patient has been treated with at least one course of h1 antihistamines and is refractory to this treatment patient has provided written informed consent allowing the use of their anonymous data for the purposes of the study exclusion criteria: patient is currently participating in a clinical trial. patient is, in the opinion of the treating physician, unlikely to be available for the full duration of the follow-up period of 24 months
chronofolfox plus avastin for patients with metastatic colorectal cancer

Conditions: Colorectal Neoplasms

Summary: to determine efficacy in the delivery of chronomodulated chemotherapy.

the purpose of this study is to determine if treatment with 5-fluorouracil, leucovorin, oxaliplatin, and avastin will cause colorectal tumor cells to shrink or disappear. the study will also determine the safety of these drugs when given together and the quality of life of the patients who are enrolled in the study. it is thought that these drugs will be better tolerated if they are chronomodulated, i.e., if they are given at certain times of day rather than as a continuous infusion.

Eligibility criteria:
inclusion criteria: * histological proof of adenocarcinoma in primary colon or rectum tumor. * evidence of metastatic colorectal cancer or loco-regional recurrence or unresectable disease. * ages 18 to 86 years. * presence of at least one bi-dimensionally measurable disease with at least one diameter \> or = 2 cm. * who/ecog performance status \< 3 (0, 1, or 2) * prior treatment with oxaliplatin, 5-fu, or leucovorin permitted. * signed informed consent exclusion criteria: * peripheral sensory neuropathy \> or = grade 3. * serum bilirubin (total) \> 3 x uln. * symptomatic or uncontrolled brain metastasis. * metastases limited to bone, pleural effusion, or ascites. * uncontrolled overt cardiac disease. * uncontrolled hypercalcemia. * uncontrolled infections. * uncontrolled hypertension (\>180/110) * history of gi perforation. * history of arterial thromboembolic events. * history of congestive heart failure. * patients taking warfarin (coumadin). * patients who are pregnant.

Keywords: advanced metastatic colorectal cancer avastin
assisting obsessive compulsive disorder (ocd) patients with discontinuing long-term serotonin reuptake inhibitors (sris)

Conditions: Obsessive Compulsive Disorder

Summary: this study will address questions of fundamental clinical significance including: (1) whether ocd patients maintained on long term sris can be discontinued without symptom exacerbation, (2) whether trans-diagnostic cognitive-behavioral treatment will reduce worsening following discontinuation compared to taper and monitoring, and (3) whether predictors of successful sri discontinuation can be identified.


Eligibility criteria:
inclusion criteria: 1. 18 or older 2. presence of mild to moderate ocd symptoms 3. patient's treating clinician agrees that sri discontinuation is clinically appropriate 4. adequate trial of sri (≥10 weeks) in the current treatment episode 5. maintenance on sri dose that has not increased due to significant clinical worsening in the two years prior to enrollment 6. english speaking exclusion criteria: 1. clinically significant suicidality or a suicide attempt within the past year 2. presence of any clinical features warranting a higher level of care (partial or inpatient hospitalization) 3. current or recent (past 6 months) alcohol or drug dependence or abuse 4. current or past psychotic disorder or bipolar disorder 5. moderate to severe depression, as indicated by a hamilton rating scale for depression (hrsd) (17-item) ≥ 14 or recent major depressive episode (past 6 months) 6. history of severe ocd (ybocs ≥ 28) 7. prior adverse experience with sri discontinuation 8. primary compulsive hoarding 9. cognitive impairment that would interfere with study participation 10. concomitant psychosocial treatment w/ proven efficacy in the treatment of ocd 11. previous adequate trial of exposure-based treatment (e.g., history of 12 or more sessions) in past 5 years 12. use of non-sri psychotropic medications for ocd in the 3 months prior to enrollment.
capadenoson in angina pectoris

Conditions: Chronic Stable Angina

Summary: this is a multi-center and multi-national,randomized, double blind, placebo-controlled, 28-day treatment study with bay 68-4986 taken orally or a matching placebo.


Eligibility criteria:
inclusion criteria: * the primary diagnosis is chronic stable angina of mild-moderate intensity as defined by the canadian cardiovascular society functional class ii-iii, in the presence of definitive coronary artery disease. * male or female subjects aged 35 to 75 years (if female, only if postmenopausal or permanently sterilized) * stable angina of mild-moderate intensity (canadian class ii-iii) with anti-anginal medication not changed for the last 5 weeks exclusion criteria: * inability to withdraw current anti-anginal therapy * inability to withdraw any concomitant therapy that would interfere with interpretation of study results

Keywords: adenosin agonist chronic stable angina