Kornimate/medical-research-clean huggingface dataset:
an open label study assessing the 24-hour intraocular pressure pattern in pac and pacg patients, before and after laser peripheral iridotomy

Conditions: Glaucoma

Summary: the purpose of the study is to determine the relationship of the intraocular pressure patterns recorded during 2 sessions using triggerfish, before and after elective laser peripheral iridotomy in angle closure glaucoma patients.


Eligibility criteria:
inclusion criteria: * diagnosis of primary angle closure (pac) or primary angle closure glaucoma (pacg) with indication for laser peripheral iridotomy (pac is defined by the presence of a partial or complete iridotrabecular contact in more than 2 quadrants with either raised intraocular pressure \[i.e. more than 21 mmhg\] and/or primary adhesion to the trabecular meshwork (peripheral anterior synechiae \[pas\]; however, with normal optic disc and visual field. pacg is defined by the presence of iridotrabecular contact with either raised intraocular pressure and/or pas, and evidence of glaucomatous optic disc and visual field) * no intraocular pressure-lowering drug treatment or a 4-week wash-out period prior to study day 0 and throughout the study * aged ≥18 years, of either sex * not more than 6 diopters spherical equivalent on the study eye * not more than 2 diopters cylinder equivalent on the study eye * have given written informed consent, prior to any investigational procedure exclusion criteria: * history of acute angle closure glaucoma * secondary angle closure glaucoma * history of ocular surgery within the last 3 months * history of ocular laser treatment, including previous laser peripheral iridotomy * corneal or conjunctival abnormality precluding contact lens adaptation * severe dry eye syndrome * patients with allergy to corneal anesthetic * patients with contraindications for silicone contact lens wear * patients not able to understand the character and individual consequences of the investigation * participation in other clinical research within the last 4 weeks
endothelial function as a marker for blood pressure control among hypertensive diabetic patients

Conditions: Hypertension; Diabetes Mellitus Type 2

Summary: our aim is to examine the influence of blood pressure and glycemic control together with n-acetylcystein utilization on the endothelia function of hypertensive diabetic patient.the study population will include 50 diabetic patient with uncontrolled hypertention that will be recruited from the hypertension clinic of soroka university medical center.


Eligibility criteria:
inclusion criteria: * diabetic patients with uncontrolled hypertension that will be recruited from the hypertension clinic of soroka university medical center exclusion criteria: * pregnancy,secondary hypertention,malignancy or other serious illness
accuracy of continuous glucose monitoring in patients with diabetes. a prospective observational study

Conditions: Diabetes Mellitus; Dysglycemia; Perioperative Complication; Circulatory; Complications

Summary: the goal of this observational study is to investigate the accuracy of the continuous glucose monitoring (cgm) compared to standard point-of-care (poc) blood glucose measurements in patients with diabetes in patients who during their hospital admission can experience circulatory impairment. the main questions it aims to answer are: • do cgm measurements have a decreased accuracy compared to standard blood glucose measurements in periods with circulatory impairment? participants will be asked to wear a blinded cgm device (dexcom g7, dexcom inc.) during their stay in the hospital but will receive standard care of their diabetes. the cgm device will be worn for up to 10 days.

this is a prospective observational study on patients living with diabetes who a) undergo surgery at the department of vascular surgery, rigshospitalet, denmark and the surgical department and department of orthopedic surgery and traumatology, bispebjerg and frederiksberg hospital, denmark, or b) are admitted to the intensive care unit (icu) at bispebjerg and frederiksberg hospital with circulatory impairment. the study aim is to investigate the accuracy of the dexcom g7 cgm in patients with diabetes undergoing surgery and in patients at the icu with circulatory impairment. the glucose readings will be compared to standard practice with poc blood glucose measurements. included patients will be asked to wear the cgm device dexcom g7 for up 10 days. the study will include 60 patients this study is part of an overall project that aims to investigate the use of cgm and continuous wireless monitoring of vital signs in patients with diabetes undergoing major surgery. using this technology, postoperative complications including dysglycaemia can potentially be detected and treated earlier thus improving the perioperative care.

Eligibility criteria:
inclusion criteria: * medical history with diabetes mellitus requiring antidiabetic drugs * age ≥18 years * surgery with estimated surgery time ≥45 minutes with expected stay for at least one night in hospital postoperatively or * admission to the icu with circulatory impairment defined as need of vasopressors to maintain a mean arterial pressure (map) ≥65 mmhg and peripheral perfusion index \<1.5 exclusion criteria: * local skin symptoms including infection at the posterior aspect of the upper arm that does not allow the sensor to be placed on an unaffected skin area * contraindications to skin puncture (arteriovenous fistula for dialysis, post-mastectomy lymphoedema etc) * known allergy to plaster used in the cgm device

Keywords: diabetes mellitus continuous glucose monitoring medical devices
maximizing independence at home (mind at home)

Conditions: Memory Disorders; Dementia

Summary: funded by a unique private philanthropy and public coalition through the associated: jewish community federation of baltimore, this project seeks to develop effective ways to deliver dementia care to older adults with memory disorders who live in the community. mind at home is an 18 month intervention research study whose goals are two-fold: to partner with community organizations to help proactively identify older adults in the baltimore community who may need help related to memory disorders; to find out if providing person-centered, coordinated care will help older adults with memory disorders remain at home longer, as well other possible benefits. the investigators hypothesize that individuals with memory disorders that receive person-centered, coordinated care will have fewer unmet dementia-related needs, improved quality of life and function, fewer behavioral and depressive symptoms, and will be able to remain in their homes longer compared to individuals who receive augmented usual care.


Eligibility criteria:
inclusion criteria: * 70+ years old * community living (within one of 28 zip codes in baltimore) * has memory disorder * has identified study partner willing to participate * english-speaking exclusion criteria: * situation at the time of referral is an emergency with risk of danger to individual or others * presence of delirium or other rule outs for memory disorder

Keywords: care coordination dementia care intervention unmet needs community older adults caregiver
prevalence of non-alcoholic fatty liver disease in patients with chronic kidney disease in assiut

Conditions: CKD; NAFLD

Summary: the goal of this observational study is to detect the prevalence of nafld in ckd patients the main question\[s\] it aims to answer are: * \[question 1\] prevalence of nafld in ckd patients. * \[question 2\] the relationship between nafld and ckd.

the goal of this observational study is to detect the prevalence of nafld in ckd patients the main question\[s\] it aims to answer are: * \[question 1\] prevalence of nafld in ckd patients. * \[question 2\] the relationship between nafld and ckd.

Eligibility criteria:
inclusion criteria: * ckd patients exclusion criteria: * hcv and hbv positive patients * alcoholics * patient on hemodialysis * patients with wilson disease * patients with alpha one antitrypsin deficiency
an effectiveness and safety 6 months study of 3 injections one week apart of synolis va 40/80 in the treatment of symptomatic knee osteoarthritis

Conditions: Osteo Arthritis Knee

Summary: multicentre, independent assessment study on synolis va 40/80 over a period of 24 weeks


Eligibility criteria:
inclusion criteria: * patient between 35 and 75 years old * patients with knee osteoarthritis. the diagnosis is based on the following american college of rheumatology (acr) classification: * knee pain * positive radiography (presence of osteophytes) * morning stiffness \< 30 min and/or crepitus while walking * symptoms related to knee osteoarthritis for at least 6 months * treatment failure (i.e. ineffective response) with analgesics and/or nsaids or intolerance to nsaids or low-grade opioids * kellgren-lawrence radiographic stage: i - iii (pre-inclusion radiography) * vas pain index score ≥ 40 mm (vas 0-100 mm) on the knee to be treated * contralateral knee pain \< 10 mm (vas) compared to treated knee * patient signed inform consent form exclusion criteria: * inability to understand the study or language used to be informed/sign the consent * participation in another clinical trial within 4 weeks prior to the start of the trial, and commitment to non-participation within 4 weeks following the end of the trial * intraarticular injection of hyaluronic acid in target knee within the 6 months prior to inclusion * patient who has received an intra-articular (ia) or intra-muscular (im) steroid injection within the 3 months prior to inclusion or has taken oral corticosteroids within the month prior to inclusion * joint, bone, ligament, or any local or loco-regional surgery of the leg involved, arthroscopic operation on the target knee within the 3 months prior to inclusion * any recent trauma to the leg involved, including a sprain, dislocation within the 3 months prior to inclusion * rheumatoid arthritis, joint condition or any other inflammation and arthritis * lupus * dermatological disorder or any epidermal conditions that prevent an intraarticular injection * visible remarkable joint effusion of the target knee during physical examination evidenced by a protuberance or positive ballottement of the patella * evidence of a subchondral fracture, meniscal lesion, presence of bone or cartilage fragments, horizontal meniscal lesion tear (flap) in the target knee * osteonecrosis (1 or both knees) * daily dosage \> 101 mg of acetylsalicylic acid as part of cardiovascular preventive treatment (antithrombotic). if dose \< 101 mg, must be maintained during the study * known intolerance/hypersensitivity/allergy to any of the components in either product, synolis va * fibromyalgia * patient of childbearing potential, pregnant or breast-feeding known at inclusion or in the planning phase during the study unless willing to use contraceptives through the whole duration of the study * excessive and repeated consumption of alcohol or illicit substances * any medical condition that may interfere with the proper conduct of the study (including any surgery or hospitalisation)

Keywords: osteoarthritis knee osteoarthritis hyaluronic acid
the effect of whey protein consumption on hypoglycemia in adults with type 1 diabetes during fasting ramadan.

Conditions: Type1 Diabetes; Fasting; Nutrition, Healthy

Summary: cross over randomized design for adding whey protein to suhoor meal for patients with t1dm during fasting ramadan

patients with type1 diabetes who intend to fast will be supplied with dietary supplement "whey protein" to be taken with suhoor (predawn meal) for one week during ramadan. they will be then crossed over to not taking the whey protein for another week. the order of taking whey protein will be randomized. during both weeks patients will be monitored through flash continuous glucose monitoring and data will be compared in regards to incidence and timing of hypoglycemia, hyperglycemia, and time in target range. after ramadan data will be collected on number of days they had to brake fast due to low blood sugar during both weeks and overall satisfaction with using whey protein during ramadan.

Eligibility criteria:
inclusion criteria: 1. type 1 diabetes mellitus 2. age \>14 years 3. committed to do regular smbg or on cgm 4. on multiple daily injections or insulin pumps 5. on carbohydrate counting for meal dosing 6. have previously fasted ramadan 7. willing to fast ramadan this year 8. well-educated about requirements for fasting ramadan exclusion criteria: 1. hypoglycemia unawareness 2. cognitive impairment or learning disability 3. renal and hepatic impairment 4. adrenal insufficiency 5. pregnancy 6. alcohol consumption 7. any diagnosed psychiatric disease 8. sensor-augmented insulin pumps 9. hba1c \>12% 10. already on protein supplements
the real-world endeavor resolute versus xience v drug-eluting stent study in twente

Conditions: Coronary Artery Disease; Angina Pectoris; Unstable Angina Pectoris; Coronary Stenosis; Coronary Restenosis

Summary: the twente study is a single center prospective single-blinded randomized study. randomization will involve the type of drug-eluting stent (des) used in study population. patients will be blinded to the type of des they will receive. the general practitioner of the patient will be requested not to disclose this information to the patient. analysts who perform the data analyses will be blinded to the type des used as well.

primary research questions to investigate whether the clinical outcome following the randomized implantation of the endeavor resolute® versus xience v® drug-eluting stent is similar, as assessed in a non-inferiority setting by comparing target-vessel failure (tvf) of both stents. we want to compare for both drug-eluting stents the combined endpoint of death, myocardial infarction or revascularization related to the target-vessel, as well as death or myocardial infarction that cannot be related to a significant flow obstruction in another vessel or to another cause. according to current literature, non-inferiority of endeavor resolute ® and xience v® is expected. but the non-inferiority of endeavor resolute and xience v® is not tested in a controlled randomized trial yet.

Eligibility criteria:
inclusion criteria: * indication for pci with des implantation based on vvc/esc guidelines and/or clinical decision of interventional cardiologist * age ≥ 18 years and mentally capable to give an informed consent * signed informed consent exclusion criteria: * patients with st-elevation myocardial infarction (stemi) or an st- elevation myocardial infarction equivalent requiring primary pci or rescue pci * patients in whom the revascularization procedure is planned to be performed in a staged approach * renal failure requiring haemodialysis * patient is currently participating in an investigational drug or device study that has been not completed * in the investigators opinion patient has a co-morbid condition(s) that could limit the patient's ability to participate in the study, compliance with follow-up requirements or impact the scientific integrity of the study * life expectancy less than 1 year * patients in whom during pci there is no indication for des use and/or if the operator chooses not to use a des based on the clinical situation, the patient will be excluded. * if the choice of des is dictated by logistic reasons e.g. the required des dimensions is provided by one manufacturer only.

Keywords: twente randomized study stent coronary stent drug-eluting stent zotarolimus everolimus xience v endeavor resolute head to head comparison real world patients target vessel failure investigator initiated study coronary artery disease coronary arteries atherosclerosis non inferiority
guidelines for post-exercise dietary intake in t1dm

Conditions: Type 1 Diabetes Mellitus

Summary: the investigators hypothesise that manipulating the glycaemic index of the meal after exercise and before sleep will help prevent type 1 diabetes individuals experiencing hypoglycaemia.


Eligibility criteria:
inclusion criteria: * aged between 18-50 years old (male or female). * free from any diabetes related complications (apart from mild background diabetic retinopathy). * hba1c \<8.5%. * not taking any prescribed medication other than insulin, and treated with a stable insulin regimen composed of a combination of slow/long acting insulin (glargine or detemir) and fast-acting insulin analogues (lispro or aspart), for a minimum of 6 months before the start of the study. * demonstrate normal cardiac function in response to exercise. exclusion criteria: * aged younger than 18, or older than 50 years. * suffering from, or diagnosed with a diabetes related complication (apart from mild background diabetic retinopathy). * hba1c \>8.5%. * currently taking prescribed medication, and not currently treated with a stable basal bolus regimen composed of a combination glargine or determir, and lispro or aspart for at least 6 months before the start of the study. * failure to demonstrate normal cardiopulmonary responses during exercise, or have a medical condition which could prevent completion of exercise or be exacerbated because of.

Keywords: t1dm, exercise, hypoglycaemia
a natural history study of neuronal ceroid lipofuscinosis type 5 (cln5)

Conditions: Ceroid Lipofuscinosis, Neuronal 5

Summary: cln5 is a form of batten disease, a neurodegenerative disorder in children causing psychomotor regression, seizures, blindness, loss of ambulation and premature death, and has no available treatments. the purpose of this study is to investigate the clinical characteristics and natural clinical progression of symptoms in individuals with cln5. this natural history study is important to better understand disease course to be able to determine clinically relevant outcome measures for use in future clinical trials.

neuronal ceroid lipofuscinosis (ncl) are comprised of a group of fatal neurodegenerative diseases caused by mutations in an enzyme or protein which results in the accumulation of toxic deposits in the eye, brain, skin, muscle and other cells. cln5 is a type of ncl, caused by homozygous or bi-allelic heterozygous variants in the cln5 gene. lack of cln5 protein impairs the breakdown of certain proteins, leads to defective lysosomal trafficking, resulting in accumulation of toxic material and subsequent cell damage. cln5 disease presents in childhood with neurological findings including motor clumsiness and attention disturbances, followed by progressive visual failure, psychomotor depression, epilepsy, and premature death. no investigational product will be provided in the study.

Eligibility criteria:
inclusion criteria: 1. age at disease onset of ≤ 5 years of age. 2. molecular genetic diagnosis confirming the presence of pathogenic or likely pathogenic variant(s) on both alleles (biallelic) of the cln5 gene. for prospective arm only: 1. subject age of ≤ 9 years. 2. hamburg motor and vision score of ≥ 1 at time of consent. 3. subject must have a caregiver available to support the subject and attend visits with the subject. exclusion criteria - all subjects: 1. has another neurologic disease or illness that may have caused cognitive decline before study entry. 2. has a known pathogenic or clinically suspected mutation in a seizure associated genetic mutation besides cln5. 3. any prior participation in a study in which a gene therapy vector or stem cell transplantation was administered. 4. participation in other investigational studies and non-interventional studies that have similar study assessments as this protocol while the subject is enrolled in this study is prohibited.

Keywords: cln ncl batten
immune checkpoints in colorectal cancer

Conditions: Colorectal Cancer

Summary: colorectal cancer (crc) ranked the first in cancer incidence in hong kong and it is frequently lethal with heterogeneous drug responses and survival outcomes. immune-based approaches targeting to enhance tumor-specific responses have been actively under investigation as therapeutic strategies. currently, pd1 and pd-l1 blockade has shown promising results in clinical trials especially in colorectal cancer patients with microsatellite instability. this study aims to examine the role of pd-l1/pd1 in immune cell-mediated cytotoxicity in colorectal cancer patients.

aim: to examine the role of pd-l1/pd1 in immune cell-mediated cytotoxicity in colorectal cancer patients. objectives: 1. comprehensive investigation of pd-l1/pd1 in colorectal cancer in association with chemotherapy responses and immune activities; 2. examine the functional role of pd-l1/pd1 targeting in immune cell-mediated cytotoxicity. hypothesis: it is hypothesized that pd-l1/pd1 has pivotal role on the immune cell-mediated cytotoxicity in colorectal cancer. significances: the current study will elucidate the significance of pd-l1/pd1 on chemo-resistance and the effect on immune cells and their functional properties. the study will enhance the understanding on chemotherapy response and immune evasion. the long-term goal is to provide the crucial information on oncoimmunology to improve efficacy of immunotherapy in cancer treatment. subjects: only those patients for whom colorectal cancer is the indicated clinical diagnosis will be recruited in the current study. possible participants will be patients undergoing tumor resection or endoscopic examination at the department of surgery, prince of wales hospital, shatin, hong kong. specimens will be collected from sixty-eight colorectal cancer patients. the estimated duration for collection of all the necessary samples will be two years. with at least one year of follow-up information, the proposed study should be completed in three years. for the current study, single blood sample (10 ml of peripheral blood in edta) will be drawn before the operation or endoscopic session. a small portion of the tumor and non-tumor tissue tissues from resected specimens or biopsy tissues will be collected for histological evaluation, primary culture and for comparison of the genetic and protein components in the blood specimen.

Eligibility criteria:
inclusion criteria: * colorectal cancer patients undergoing resection or endoscopic examination at the department of surgery, prince of wales hospital, shatin, hong kong exclusion criteria: * patients who do not consent
biomechanical analysis of arterial tissue from patient suffering from peripheral artery disease in the lower limb

Conditions: Peripheral Arterial Disease

Summary: the current treatment approaches for peripheral artery disease are largely unsatisfactory. therefore, diseased tissue will be collected as well as patient-specific arterial geometries. the tissue will be tested microstructurally and mechanically to obtain data required to optimize treatment methods through in silico modeling.

peripheral artery disease (pad) is a severe cause of morbidity in patients. common treatment approaches are too often still unsatisfactory. angioplasty is commonly followed by restenosis, caused by overloading of the arterial tissue. this study is aimed at improving this treatment approach through the in silico simulation of arterial remodeling after balloon expansion. such simulations require the input of a patient-specific geometry and the mechanical properties of (diseased) arterial tissue. patients scheduled for an above knee lower limb amputation due to critical ischemia will be recruited in this study. after the surgery, the femoralis superficialis will be collected, as well as the ct or mr angiogram obtained before the surgery. the arterial tissue will be mechanically tested to obtain material properties and the medical image will be used to determine the arterial geometry. a correlation study will be carried out to explore the possibility of including a predictive simulation of the restenosis outcome of balloon angioplasty in the clinical practice.

Eligibility criteria:
inclusion criteria: * patients suffering from critical ischemia in the lower limb and undergoing above-knee amputation exclusion criteria: * the presence of any feature that will prevent tissue collection after the amputation