Kornimate/medical-research-clean huggingface dataset:
comparison of piezoelectric split-crest technique versus expansion using hand driven ridge expanders in treatment of maxillary narrow ridges

Conditions: Edentulous Alveolar Ridge

Summary: comparison of piezoelectric split-crest technique versus expansion using hand driven ridge expanders in treatment of maxillary narrow ridges


Eligibility criteria:
inclusion criteria: * participants are free from any systemic diseases. * participant have missing one or two premolars or molars with sufficient alveolar ridge height and insufficient alveolar ridge buccolingual (bl) width that interfere with conventional straight forward implant placement. * the minimum bl ridge width included in the study will be 3.5 mm to facilitate ridge splitting and expansion exclusion criteria: * patients with residual infections in the edentulous areas. * medically compromised groups. * smokers and patients with poor oral hygiene.
a comparison between pupillometry, heart rate variability and metaiodobenzylguanidine scintigraphy for the diagnosis of early diabetic autonomic neuropathy in type 1 diabetes

Conditions: Autonomic Neuropathy

Summary: this study will examine if one of the following methods: pupillometry, spectral analysis of heart rate variability and metaiodobenzylguanidine scintigraphy, is more capable to detect early diabetic autonomic neuropathy in patients with type 1 diabetes mellitus


Eligibility criteria:
inclusion criteria: * type 1 diabetes mellitus exclusion criteria: * type 2 diabetes mellitus * severe cardiac autonomic neuropathy * medications other than insulin * ocular disease other than refractive eye disorders * history of neurologic disease * history of cardiovascular disease * thyroid disease * vitamin b insufficiency * other possible cause for autonomic failure
investigating exercise in myotonic dystrophy type 2 (dm2)

Conditions: Myotonic Dystrophy 2

Summary: an exercise regimen (prime: proximal resistance in-house movement exercise) has been designed for patients with myotonic dystrophy type 2 (dm2). the hypothesis is that this patient-friendly physical therapist (pt)-guided exercise program associates with improved functional capacity and muscle composition in dm2 in this two-period two-sequence cross-over study. thus, participant will be randomized to one of the three possible groups. participants in group a will perform exercise routine in clinic under the direct supervision of a physical therapist twice a week for the first three months, then they will continue with same exercise routine at home for the last 3 months on their own. participants in group b will perform exercise routine virtually under the direct supervision of a physical therapist twice a week for the first three months, then they will continue with same exercise routine at home for the last 3 months on their own. participants in group c will perform exercise routine on their own during the first 3 months, then they will perform exercise routine virtually under the direct supervision of a physical therapist. each group will include around 8 participants. duration of the study is 6 months. in addition to exercise sessions, participants will have evaluation of their strength, motor function and muscle composition at three time points: initiation, 3 months and completion of the study at 6 months. muscle composition will be assessed by electrical impedance myography which is a portable, non-invasive, painless and non-radiation tool that applies a weak high multifrequency electrical current to the examined muscle and allows to obtain information about its composition.


Eligibility criteria:
inclusion criteria: * patients with genetically confirmed myotonic dystrophy 2 (dm2) who are ≥18 and ≤ 70 years old. * patients are ambulatory without need of any assistance or device. * patients have a normal ecg within the 3 months prior to screening visit (of note, patients with dm2 are recommended to have routine ecg as part of patient care. so, this ecg will be done as part of patient care). * body mass index (bmi) ≥20 and ≤30. exclusion criteria: * subjects younger than 18 years old or older than 70 years old. * inability or unwillingness of the subject to give written informed consent. * subjects with pacemaker. * blood pressure \ 160 mmhg/90 mmhg at screening visit * resting heart rate of \ 100 beats/minute at screening visit. * any fall within the last six months. * any history of syncopal episodes or family history of sudden death. * patients who are pregnant or plan to become pregnant. a urine pregnancy test will be performed at visit 1 and 3 for women of childbearing age. if positive or if subject is planning to become pregnant, subject will be not eligible for the study.

Keywords: exercise physical therapist myotonic dystrophy type 2 electrical impedance myography
measurement of activity participation for persons with schizophrenia living in the community

Conditions: Schizophrenia

Summary: the purpose of the study is to develop a questionnaire on community occupational participation for persons with schizophrenia living in the community. in the international classification of functioning, disability, and health (icf) recently revised by world health organization, activity participation is recognized as an important indication of health-related status. from the perspective of occupational therapy, the researcher intends to investigate the experiences of occupational participation among schizophrenic patients living in the community, and to develop a measuring tool for occupational participation accordingly. the development of the community occupational participation questionnaire will be based on the result of a qualitative research project which the researcher is carrying out at the moment. the resultant questionnaire will provide a quantitative measure of community occupational participation for persons with schizophrenia, as well as a measurement tool of activity participation for health-related research studies. furthermore, it may provide valuable information to the development of community psychiatric services. this current study will take one year. tasks to be accomplished include: building item pool, examining content validity of each item, pilot testing, item analysis, norm establishment, and testing reliability and validity. data will be collected in different areas of taiwan, and will be analyzed with the following methods: content validity ratio, item-total correlation, cronbach's alpha, and confirmatory factor analysis. the study will result in an occupational participation questionnaire with norm, validity and reliability.

first, the participants were informed the right and how to fill the self-report survey questionnare in. and then they began to complete the questionnare. after finishing it, the participants gave the questionnare back to the examinor and got a gift as a reward.

Eligibility criteria:
inclusion criteria: * person with schizophrenia * must be able to read chinese * majorly living in community
study to assess the safety and tolerability of azd1152 in combination with low dose cytosine arabinoside (ldac)

Conditions: Acute Myeloid Leukemia

Summary: a study to assess the safety and tolerability of azd1152 in combination with low dose cytosine arabinoside (ldac) in patients with acute myeloid leukaemia (aml). the first three patients to complete a 28 day cycle in the cohort, before the second three patients start treatment.


Eligibility criteria:
inclusion criteria: * newly diagnosed patient. * provision of written informed consent. * de novo (primary) or secondary aml. * not eligible for intensive induction chemotherapy because of medical, social or psychological reasons. exclusion criteria: * patients with aml of fab m3 classification acute promyelocytic leukaemia (apl). * patients with blast crisis of chronic myeloid leukaemia. * persistent, chronic, clinically significant toxicities from any prior anti- cancer therapy greater than ctcae grade 1 (except alopecia).

Keywords: acute myeloid leukaemia (aml)
a trial on the effectiveness of screening and brief problem-solving therapy (pst) for elderly patients with psychological problems

Conditions: Undiagnosed Psychological Problems

Summary: the aim of this study was to determine whether screening followed by brief psc provided by primary care doctors could improve the quality of life of elderly patients with unrecognized psychological problems in primary care. the following hypotheses were tested: 1. elderly patients screened positive of psychological problems had poorer health-related quality of life (hrqol) than those who were screened negative. 2. primary care doctors could be trained to provide brief pst. 3. brief pst by a trained primary care doctor could improve the hrqol of the elderly who were screened positive for psychological problems.

design \& methods: a prospective single-blind randomised controlled trial (rct) on 299 patients aged 60 or above without any known psychological diseases but screened positive for psychological problems by the hospital anxiety and depression scale (hads). subjects were randomised to problem-solving (pst) or video-viewing (placebo). all subjects continued with their usual care and were followed up by telephone at 6, 12, 26 and 52 weeks.changes in sf-36 hrqol scores, hads scores and monthly consultation rates at 6, 12, 26 and 52 weeks within groups and between groups.

Eligibility criteria:
inclusion criteria: * aged 60 or above * not known to have any psychological problem * hads depression score 6 or above, or anxiety score 3 or above * written consent to study exclusion criteria: * known psychological disease diagnosed by a registered doctor * history of taking any psychotropic drug prescribed by a registered doctor within the last year; * suicidal plan or strong suicidal thought; * psychotic symptom; * impairment in cognitive function; or * communication problem.

Keywords: mental health problem-solving therapy elderly health-related quality of life primary care chinese
novel influenza a (h1n1) surveillance registry

Conditions: Novel Influenza A; H1N1; Influenza

Summary: the demographic characteristics, clinical features, course, and outcomes of severe h1n1 influenza infection requiring intensive care have not been defined rigorously and systematically. while the majority of patients in early reports of critically ill novel influenza a (h1n1) have respiratory involvement, up to 10-20% may present with non-respiratory organ failures, such as shock, seizures, or acute renal failure. the burden of disease and resource utilization of these patients remains largely unknown. the purpose of this surveillance registry is to characterize the demographics, clinical features, outcomes, and resource utilization of patients with h1n1 influenza infection who require intensive care.


Eligibility criteria:
inclusion criteria: * admission to an intensive care unit at a participating site with confirmed or suspected novel h1n1 influenza infection exclusion criteria: * influenza-like illness due to non-influenza disease and negative testing for influenza
chronic non-specific neck pain treated with tai chi and chiropractic care

Conditions: Neck Pain; Chronic Pain

Summary: this feasibility project aims to evaluate the effectiveness of chiropractic care combined with tai chi (tc) training to reduce pain and disability in adults with chronic non-specific neck pain (cnnp).

this is a three-armed, mixed-methods pilot study. 48 adults with cnnp will be randomized to receive either 1) 10 chiropractic treatments (delivered over 16 weeks) with concurrent tc training (16 weeks of group training) plus enhanced usual care (euc) with cnnp educational materials); 2) chiropractic care plus euc; or 3) euc alone. individuals will be followed for 8 weeks after the end of their intervention period to assess longer-term outcomes. our primary outcomes will be focused on the feasibility of recruiting, retaining and monitoring the safety of adults with cnnp into our trial. secondary clinical outcomes include following patients centered-outcomes: pain, disability, health-related quality of life, self-efficacy, cognitive and affective outcomes (postural awareness, pain catastrophizing, fear of movement, interoceptive awareness).

Eligibility criteria:
inclusion criteria: * chronic nonspecific neck pain at least 5 days a week for at least 3 consecutive months * neck pain averaged over past week of 3 or more on numerical rating scale ranging from 0 to 10, with 10 described as 'worst neck pain imaginable' * neck disability index score of 5 or greater * agreeable to participate in all study procedures and be randomized to all intervention groups * fluent in english exclusion criteria: * currently, or having received chiropractic care in past 12 months * regular practice (on average, weekly) of yoga, tai chi or qigong in the past 6 months * any major systemic illness or unstable medical condition (e.g. parkinson's disease, cancer) or psychiatric condition requiring immediate treatment or that could lead to difficulty complying with the protocol * any disability precluding exercise practice * history of stroke, carotid artery dissection, or vertebral artery dissection * signs of myelopathy or carotid bruits or evidence of pathological hypermobility (e.g. ehlers danlos syndrome) during the clinical exam * neck pain caused by congenital deformity of the spine that contraindicate treatment, neck pain related to neoplasm, inflammatory rheumatic disease, neurological disorder, active oncologic disease, severe affective disorder, addiction, or psychosis * neck pain associated with unstable radicular pain or radiculopathy * pregnancy * recent spinal injections (in the past 4 weeks) * neck pain with litigation * any prior cervical surgery/spinal surgery within previous year * persons currently involved in a disability/accident claim

Keywords: chiropractic tai chi
multicenter trial of immunotherapy with house dust mite allergoid

Conditions: Rhinoconjunctivitis

Summary: multicenter immunotherapy house dust mite allergoid

a multicentre randomized placebo-controlled double-blind clinical trial for evaluation of safety and efficacy of a specific immunotherapy with an aluminium hydroxide-adsorbed allergoid preparation of house dust mite (dermatophagoides pteronyssinus) in patients with rhinitis/rhinoconjunctivitis and/or allergic asthma bronchiale

Eligibility criteria:
inclusion criteria: * positive spt * positive east * positive specific provocation test exclusion criteria: * serious chronic diseases * other perennial allergies

Keywords: house dust mite allergen aluminium hydroxide-adsorbed
successful transitions and reintegration tools for veterans (start-vets)

Conditions: Substance Use Disorder; Mental Illness; Recently Incarcerated

Summary: this study will develop prison reentry materials for veterans leaving prison.

this study will be conducted in three phases phase 1is to collect qualitative data from veterans who have recently been released from prison. the data will focus on their transition experience, stigma (both self and from others), and behaviors that interfered with success. phase 2a will be to develop a transition program based around the needs identified in phase 1 phase 2b will be to develop assessment tools to be used with the program phase 3 will be to perform a two group randomized cross over design pilot study to assess the program

Eligibility criteria:
inclusion criteria: * veteran with mental illness and/or substance use disorder released from prison within the past 36 months exclusion criteria: * psychosis or cognitive impairment precluding active participation

Keywords: reentry mental illness prison substance use disorder
spio-enhanced mri in oral cancer for sentinel lymph node identification

Conditions: Head and Neck Squamous Cell Carcinoma

Summary: to explore the feasibility of sentinel lymph node identification by spio injection followed by mri in head-and-neck cancer patients.


Eligibility criteria:
inclusion criteria: * male or female aged \>18 years. * patients with histopathologically proven ct1-2n0m0 squamous cell carcinoma of the oral cavity. * patients planned to undergo routine sentinel node biopsy with 99mtc-radioisotope and spect-ct. * patient provided written informed consent. exclusion criteria: * patients who underwent previous surgery or radiotherapy to the neck. * contra-indications to spio (hypersensitivity to iron oxide or dextran compounds, presence of iron overload disease (hereditary hemochromatosis, hemosiderosis, chronic hemolytic anemia (e.g. thalassemia, sickle cell anemia)) * contra-indications to mri: epilepsy, claustrophobia, metallic splinters, pacemaker, pacemaker wires or implanted defibrillator, implanted magnets in jaw, metallic arterial clips (carotid arteries), pregnancy, auditory implant, neurogenic bladder stimulator, insulin pump, neurostimulator, baclofen pump, metallic tissue expander after mastectomy, cochlear implant, metallic braces, other foreign bodies implanted * unable to provide informed consent.

Keywords: sentinel lymph node identification magnetic resonance imaging superparamagnetic iron oxide oral cancer
ancora-sb overtube complete positioning and optical visualization during endoscopic procedures

Conditions: Small Bowel Disease

Summary: demonstrate superiority of the aspero medical ancora-sb balloon overtube compared to the olympus st-sb1 balloon overtube.

the study objective, demonstrate superiority of the aspero ancora-sb balloon overtube compared to the olympus st-sb1 balloon overtube, is necessary for adoption by clinicians. broad adoption is expected to improve procedure success rates, reduce time to diagnosis or treatment (thereby, improving patient outcomes), and reduce the burden and costs of care for patients, providers, and insurers. investigators propose to recruit patients scheduled for enteroscopy and use capsule endoscopy to identify patients with lesions in the middle third of the small bowel. the primary outcome of interest is success in identifying the lesion, which indicates sufficient balloon control to reach and visualize the site.

Eligibility criteria:
inclusion criteria: 1. willing and able to provide informed consent; 2. subject meets the minimal safety criteria for single balloon enteroscopy: asa class i, ii, or iii;11 3. ≥ 18 years of age to ≤ 90 years of age; 4. video capsule endoscopy identified lesions in the middle third of the small bowel; 5. willing and able to comply with all study procedures and follow-up. exclusion criteria: 1. history of gastric bypass or related procedures; 2. history of foregut and/or midgut surgery; 3. pathology identified by video capsule is in the proximal 1/3 of the bowel; 4. pathology identified by video capsule is in the distal 1/3 of the bowel; 5. anticoagulant and antiplatelet therapy that cannot be stopped for the enteroscopy; 6. capsule endoscopy did not show clear visualization of pathology in the middle small bowel; 7. inability to tolerate the investigator's method of sedation that is the standard of care; 8. any previous small bowel surgery, or anastomosis, that caused extensive adhesions and/or altered anatomy; 9. allergy to any medications or product used in the endoscopic procedure where the severe allergic reaction cannot be prevented with pre-medication; 10. pregnancy; 11. life expectancy \< six (6) months.

Keywords: small intestine
royal jelly as a strategy to modulate inflammation and oxidative stress in patients with systemic arterial hypertension

Conditions: Hypertension; Cardiovascular Diseases (CVD); Inflammation

Summary: the study aims to evaluate the effect of the royal jelly on inflammation and oxidative stress in participants with systemic arterial hypertension. a longitudinal double-blind randomized clinical trial will be carried out, involving hypertensive participants for two months.

royal jelly (rg) is considered a superfood that has been used in traditional medicine and dietary supplementation due to its antioxidant, anti-inflammatory, immunomodulatory, and regenerative properties. the antioxidant and anti-inflammatory effects of gr highlight its potential as a natural supplement for the prevention and management of several health conditions. although in vitro and animal model data are promising, clinical studies are still needed to validate the effects of royal jelly in human populations.

Eligibility criteria:
inclusion criteria: * patients using one to three antihypertensive medications, undergoing regular follow-up at the huap medical clinic for more than 6 months and without the need for changes in medication doses in the last 3 months. exclusion criteria: * patients with autoimmune and infectious diseases, diabetes, chronic kidney disease, liver disease, cancer and aids will be excluded; pregnant women; those using catabolic drugs or antibiotics; use of antioxidant vitamin supplements, prebiotics, probiotics, symbiotics, habitual intake of royal jelly, and who are allergic to cornstarch or report having an allergy to bee stings will also be excluded. patients with acute myocardial infarction (ami) and/or stroke (cva) in the last 6 months will also be excluded; with has stages 2 or 3.

Keywords: royal jelly inflammation hypertension cardiovascular diseases
abdominal wall repair with strattice in germany: a cohort study

Conditions: Hernia of Abdominal Wall; Biologic Mesh; Strattice

Summary: incisional hernia is the most frequently seen long term complication in surgery causing much morbidity and even mortality in patients. despite studies on the optimal closing technique for laparotomies, the risk for incisional hernia after midline incision remains about 5-20%. it has been established that implementing a mesh reduces recurrence of the incisional hernia but still the results of repair are often disappointing. incisional hernias can become increasingly complex due to complicated abdominal wall defects caused by a disturbed anatomy, fistulas, burst abdomen, wound and mesh infections. in these cases it is not save to repair the incisional hernia by means of a synthetic mesh and other augmentation tools need to be implemented. in the recent years the use of biological meshes has been gaining popularity. recent reports of the use of collagen-based prosthesis have suggested that they support new vessel growth, do not excite a significant foreign body reaction, form fewer adhesions, are well incorporated into host tissues with minimal wound contraction, and can be used in grossly contaminated wounds with fewer infective complications. biologic meshes are harvested from a source tissue and processed for medical use but they vary widely in their processing methods. they include tissues of human or animal origins, both chemically cross-linked and non cross-linked processes, and submucosal, pericardial, or dermal tissue sources. current studies investigating the effectiveness of these meshes are small and have short periods of follow-up. these shortcomings can be explained to high cost of the meshes and unclear indication when to use a biological mesh. the aim of this study is to investigate the short and long term effects of the strattice biological mesh. the investigators will also inquire why a biologic mesh was used and what the direct and indirect costs were.


Eligibility criteria:
inclusion criteria: * age of 18 years or older * signed informed consent * abdominal wall repair * strattice mesh implantation prior to inclusion in base cohort exclusion criteria: * age under 18 years * no signed informed consent * other operation than abdominal wall repair * other mesh than strattice mesh

Keywords: complex abdominal wall hernia biologic mesh strattice