Kornimate/medical-research-clean huggingface dataset:
artificial intelligent system for eye emergency triage and primary diagnosis

Conditions: Emergencies; Eye Diseases

Summary: ophthalmic emergencies are acute vision-threatening disorders, for which a delay in prompt emergency response could result in catastrophic vision loss. triage is an effective process for ensuring that timely emergency care is provided despite limited resource by prioritizing patients to appropriate orders for visits. historically, registered nurses classify emergency patients based on personal experiences with high variation. additionally, primary healthcare providers have been conventionally at the forefront of providing first aid care. however, most of ocular emergencies are wrongly diagnosed or referred due to non-eye specialists' limited knowledge and training in the ophthalmology. here, the investigators established and validated an artificial intelligence system, ee-explorer, to triage eye emergencies and assist in primary diagnosis using metadata and ocular images. this system has been integrated into a website to be prospectively validated in the real world.


Eligibility criteria:
inclusion criteria: 1. suffering acute ophthalmic symptoms within one month 2. visiting the ocular emergency department for the first time 3. must be able to complete the triage form for ophthalmic emergency 4. must be able to cooperate either by submitting smartphone photographs or receiving slit-lamp examination exclusion criteria: the image quality does not meet the clinical requirements.

Keywords: artificial intelligence ophthalmic emergency triage primary diagnosis multimodal data
a study to objectively measure physical activity and sedentary behavior during cardiac rehabilitation

Conditions: Cardiac Disease; Myocardial Infarction; Cardiac Valve Disease; Coronary Artery Disease

Summary: the purpose of this study is to assess exercise patterns during home-based or center-based cardiac rehabilitation participation.

participants enrolled in either home-based or center-based cardiac rehabilitation will be instructed to wear an accelerometer device for 7-days at baseline, 4-weeks, 8-weeks, and 12-weeks, to objectively measure their physical activity level during the cardiac rehabilitation program. a questionnaire will also be completed by the participant at baseline and 12-weeks to subjectively measure their physical activity level, based on self-report activities over the previous 7-days. enrollment in home-based versus center-based cardiac rehabilitation will be based on the availability of cardiac rehabilitation facilities and/or patient preference. there is no random allocation or assignment to groups by the study team.

Eligibility criteria:
inclusion criteria: * adult 18 years and older. * able to provide consent. * has a qualifying indication for cardiac rehabilitation and able to participate in cardiac rehabilitation. exclusion criteria: * unwilling or unable to participate in cardiac rehabilitation.

Keywords: cardiac rehabilitation physical activity accelerometry home-based
optimizing communication during ventilation

Conditions: Neuromuscular Disorder; Respiratory Failure

Summary: mechanical ventilation is one of the only treatment that has improved survival of patients with neuromuscular respiratory failure. as disease progresses, some patients may require longer ventilation period. non invasive mechanical ventilation is the preferred method of ventilation but it may interfere with speech and communication of patients who require ventilation throughout the day. the investigators are evaluating the effect on speech and communication of a ventilation device which allows patients to momentarily and voluntarily withhold ventilation if they want to speak. this should allow the patients to have a more fluid speech.


Eligibility criteria:
inclusion criteria: * patient with restrictive respiratory failure secondary to a neuromuscular disorder, without any bulbar involvement. * age greater than or equal to 18. * hospitalization in home ventilation unit of the intensive care department of r. poincaré hospital. * non invasive mechanical ventilation for a duration equal or above 14h per day. * patient in a steady state at the time of the study * written informed consent exclusion criteria: * patient's refusal to participate to the study * inability to read the selected text * inability to use the ventilator switch * inability to cooperate * hemodynamic instability * acute respiratory failure * no affiliation to social security

Keywords: neuromuscular disorder mechanical ventilation speech respiratory failure
effect of a symptom diary on symptom care and symptom burden in patients treated with chemotherapy: a before-and-after-study

Conditions: Nausea; Vomiting; Pain; Anorexia; Etcetera

Summary: this study investigates whether the implementation of a symptom diary for reporting and communicating chemotherapy-related symptoms improves symptom care and decreases symptom burden in adult patients treated with chemotherapy. the hypothesis is studied using a before-and-after design. first, symptom care and symptom burden will be observed in a sample of patients not being offered a symptom diary. next, the symptom diary will be implemented at the participating hospital and symptom care and symptom burden will now be observed in a new sample of chemotherapy patients.


Eligibility criteria:
inclusion criteria: * adult (\>18) patients with (any type of) cancer treated with chemotherapy * understanding dutch * being able to sign informed consent exclusion criteria: * more than 3 lines of chemotherapy treatment in the past
phase iii, long-term, open-label safety study of z-338

Conditions: Dyspepsia

Summary: the primary objective of this study is to evaluate the long-term safety of 100 mg z-338 tid in european subjects with fd.

this is a phase iii, multicentre, single-arm, open-label study to evaluate the long-term safety of 100 mg z-338 tid in subjects with fd. the study comprises a screening period (up to 3 weeks), a run-in period (1 week) and an open-label treatment period (52 weeks). including an additional 2-week follow-up period for assessment of aes, the maximum duration of a subject's participation in the study will be 58 weeks.

Eligibility criteria:
inclusion criteria: * subjects to provide written informed consent prior to any study procedures being performed * subjects with a diagnosis of fd (postprandial distress syndrome) as defined by the rome iii criteria * subjects must present postprandial fullness or early satiation as the most bothersome symptom during the 6 months prior to informed consent. * subjects must have a normal endoscopy result within the 6 months (3 months in case of subjects who are helicobacter pylori positive) prior to informed consent or during the screening period. exclusion criteria: * subjects on ppi(s) who are unable to discontinue ppi medication by the end of the screening period * subjects taking drugs that affect gut motility, gut sensitivity and/or acid secretion who are unable to discontinue these drugs by the end of the screening period * subjects who have received h. pylori eradication therapy during the 3 months prior to informed consent * subjects with confirmed organic gastrointestinal disease * subjects presenting with predominant complaints relieved by stool movements (irritable bowel syndrome) * subjects presenting with predominant gord symptoms * subjects presenting with predominant complaints of chronic idiopathic nausea * subjects with type i or type ii diabetes * subjects with body mass index (bmi) over 30 kg/m2 * subjects with any condition which, in the opinion of the investigator, makes the subject unsuitable for entry into the study

Keywords: z-338 functional dyspepsia postprandial distress syndrome
the effect of theraworx foam in carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: participation will be for approximately 21 days (3 study visits,1 week apart with allowance for scheduling conflicts). a topical (or placebo) foam alone or with a splint will be used. demographic and symptom information will be obtained. at each visit 3 questionnaires (bct, cts-6, and dash) will be completed and an ultrasound of the wrist (median nerve) will be done to document any change in symptoms and/or in the size of the nerve. random assignment will be to one of 4 groups: foam or placebo with or without a night splint. we will provide instruction on how to apply the foam, whether or not and how to wear the splint, and return visits.

the pi will identify potential participants from his clinical practice. evaluation of symptoms will be by exam, questionnaires, and ultrasound of the median nerve. these will document baseline/change in the size of the median nerve and improvement in function/symptoms. the questionnaires are 1.) boston carpal tunnel (bct). 2.) carpal tunnel-6 (cts-6); and 3.) disabilities of the arm, shoulder and hand (dash). these will be used to document a baseline and change (if any) in nerve size and hand symptoms, over a 2 week time frame, that are common in carpal tunnel syndrome (including numbness, pain, tingling, and/or decreased function). 1. the boston carpal tunnel is a 19 question tool that assesses function (8 items) and symptom severity (11 items). score range is from 0 to 95 with a high number indicating more severe/worsening symptoms and lower number less severe/improving symptoms. 2. the cts-6 is a six item tool that combines reported symptoms with a physical exam of the hand. scores range from 0 to 26 with a higher score reflecting increased severity. 3. the dash is a 30 item tool with each scored 1 to 5. scores can range from 0 to 150 and the higher the score the worse the symptoms/disability. treatment groups are as follows:1.) theraworx foam alone; 2.) theraworx foam with night time splint; 3.) placebo foam alone; 4.) placebo foam with night time splint. the active ingredient in theraworx foam is magnesium sulfate and will not be in the placebo foam. instructions on how to apply the foam, whether or not and how to wear the splint, and return visits will be provided. if in a group that requires night time splinting, the subject must wear the splint only at night and for a minimum of 8 hours.

Eligibility criteria:
inclusion criteria: * diagnosis of carpal tunnel syndrome * age 18 years or older * interest in non-surgical treatment of carpal tunnel syndrome exclusion criteria: * prior carpal tunnel release * non-english speaking * skin lesions/rashes on hand being treated * current use of topical anti-inflammatory medication * other diagnoses that would impact results (determined by pi)

Keywords: hand pain/numbness
proton pump inhibitors and dysbiosis in cirrhosis

Conditions: Cirrhosis; Healthy

Summary: the purpose of this study is to find out whether the use of medications that suppress acid in your stomach can change the composition of your bowel bacteria.


Eligibility criteria:
inclusion criteria for ppi initiation study: * cirrhosis not on current ppi or acid suppressive therapy * no systemic antibiotics or probiotics exclusion criteria for ppi initiation study: * on systemic antibiotics * on ppi or acid suppression therapy already * unable to give informed consent * allergy to proton pump inhibitors inclusion criteria for ppi withdrawal study: * cirrhosis on current ppi for an fda-unapproved indication * no systemic antibiotics or probiotics exclusion criteria for ppi withdrawal study: * on systemic absorbable antibiotics * on ppi or acid suppression therapy for an fda-approved indication * unable to give informed consent * unwilling to withdraw ppi
evaluating muscle weakness improvement with lorcaserin in icu

Conditions: Muscle Weakness; Sepsis

Summary: icu acquired muscle weakness is a significant problem in patients recovering from critical illness. this trial will evaluate the safety and efficacy of a drug in improving muscle weakness in critically ill patients.


Eligibility criteria:
inclusion criteria: * age ≥18 years old * sepsis \[ ≥2 systemic inflammatory response syndrome (sirs) criteria and known or suspected infection\] * muscle weakness \[medical research council sum score \<48/60 or handgrip strength \<11 kg in men and \<7 kg in women\] * obey commands \[score for dejonghe awakening score of ≥3/5\] exclusion criteria: * severe renal insufficiency \[creatinine clearance \<30 ml/min - or receiving dialysis\] * acute infectious or auto-immune hepatitis, acute liver failure or a history of cirrhosis without liver transplant * history of psychosis * bradycardia, or 2nd or 3rd degree atrio-ventricular block without pacemaker * history of valvular heart disease without valve replacement * history of priapism * pre-existing cognitive impairment * receiving drugs with serotonergic effects and/or cyp2d6 substrates which cannot be substituted stopped or titrated. * receiving sulfonylurea medication at the time of the study * prior neuromuscular or central nervous system disease, including pre-existing neuropathy * inability to perform study's muscle strength assessments based on patient's baseline status prior to hospital admission * unable to receive, or unlikely to absorb study drug (e.g. bowel obstruction, ischemia, or infarction; short gut syndrome) * body mass index \>40 * patient not expected to survive \>4 days * pregnancy or lactation * allergy to lorcaserin or lorcaserin taken in the prior 7 days * enrolled in another interventional drug or physical rehabilitation trial * physician declines for patient to be enrolled * patient or proxy declines consent * unable to reach proxy for consent * non-english speaking
ultrasound-assisted lumbar puncture

Conditions: Spinal Puncture; Diagnostic Imaging

Summary: although the lumbar puncture is a common procedure and has been performed without ultrasound for decades, other research studies suggest that there may be some benefits to using ultrasound. this study intends to see whether by using ultrasound there is increased success rate, decreased need for additional procedures, and less discomfort during the procedure.


Eligibility criteria:
inclusion criteria: 1. patients who registered for an emergency or inpatient encounter between 5/22/2017 and 5/08/2018 2. males or females 18 years of age or older 3. patients who have been identified as requiring a lumbar puncture for any therapeutic or diagnostic or therapeutic indication, as decided by the neurology staff physicians, residents, or advanced practice providers. exclusion criteria: 1. patients who are not capable of providing consent for participation in research and do not have an authorized relative or power of attorney to consent in their stead. 2. patients who require lumbar puncture in an emergency, time dependent fashion and in whom a possible delay could conceivable have a negative clinical impact. 3. patients with known abnormal lumbar spinal anatomy or prior extensive surgical fusion such that fluoroscopic or ct guidance is determined to be more clinically appropriate by the treating physicians. 4. bmi greater than 60 5. absolute contraindication to lumbar puncture such as uncorrected coagulopathy

Keywords: point of care ultrasound
the effect of video education on pain, anxiety and knowledge levels of coronary bypass graft surgery patients

Conditions: Coronary Artery Disease

Summary: the aim of this research to examine the effectiveness of video-education on pain, anxiety, and knowledge levels on adult patients undergoing coronary artery bypass graft surgery.

a video based patient education will be used in this randomized controlled study. patient education via video aims to reduce the patient's anxiety levels, control their pain, and improve their health outcomes by increasing knowledge levels. in addition, since this training is visual-based, it is aimed to provide effective learning by reducing the inequality due to sociodemographic and individual differences between participants. the video-education includes information about pre and post-surgical process and care.

Eligibility criteria:
inclusion criteria: * being at least 18 years old * being hospitalized in cardiovascular surgery clinic and cardiovascular surgery intensive care unit * undergoing coronary artery bypass graft surgery for the first time, by sternotomy method * patients who agree to participate in the research and read and sign the "informed volunteer consent form for scientific research" exclusion criteria: * patients with visual or hearing impariment * patients with psychiatric illness, * patients with known cognitive impairment (dementia, alzheimer's).
virtual reality vs. standard-of-care for comfort before and after sedation in the emergency department

Conditions: Procedural Sedation

Summary: children often need procedural sedation in the emergency department during painful procedures (such as reducing fractures). virtual reality (vr) is an immersive experience using sight, sound, and position sense. using vr may enhance distraction during the painful procedure and may reduce attention to pain. vr may also reduce anxiety during sedation induction by reducing providing an alternative stimulus. this study will randomize children (6 - 16 years old) to receive virtual reality or standard of care while undergoing procedural sedation. investigators will measure heart rate, blood pressure, satisfaction (child, parent, provider), amount of sedatives used and compare between the two groups.


Eligibility criteria:
inclusion criteria 1. children age 6 to 16 years 2. the managing physician determines need for procedural sedation 3. parents will sign a consent form and children will sign an assent form exclusion criteria 1. children with conditions that may prohibit participation or evaluation of the procedure (such as developmental delay, autism, inability to communicate) 2. triage category 1 (resuscitation) 3. facial features or injury prohibiting wearing the vr goggles

Keywords: virtual reality heart rate blood pressure
a randomized controlled trial of ambient artificial intelligence scribe technologies

Conditions: Physician Workflow; Artificial Intelligence (AI)

Summary: this is a three-arm pragmatic rct of 238 outpatient physicians at a large academic health system, randomized 1:1:1 to one of two ai scribe tools or a usual-care control group. the two-month study will observe and compare the effects of each tool prior to system-wide roll out of selected tool (anticipated spring 2025). we will use covariate-constrained randomization to balance the arms in terms of physician baseline time in notes, survey-measured level of burnout, and clinic days per week. the primary purpose of the initiative is to improve quality, efficiency, and business operations at university of california, los angeles (ucla) health, and this initiative is not being done for research purposes. the results of this operational initiative will inform the widespread roll out of ai scribe tools across all providers within the ucla health system. nevertheless, the ucla study team plans to rigorously examine and publish the impact of this intervention across the health system, which is why the study team pre-registered the initiative.

this study will assess operational-oriented outcomes across all groups. notably, all groups will eventually receive all interventions over time in this observational study of a randomized roll out of a qi initiative. moreover, the primary purpose of this initiative is operational. in other words, based on the results of this initiative, one of these tools will be eventually selected and operationalized widely across the health system. enrolled participants are randomized to one of three groups. randomization was needed to overcome secular trends, seasonal and holiday effects in december, and other factors confounding the relationship between exposure to the ai tools and the outcomes. the primary aim of this study is to evaluate the impact of two ambient ai scribe technologies on clinician change from baseline time spent on ehr documentation, comparing each scribe to a control group. secondary objectives include assessing the ai scribes' impact on clinician metrics such as burnout, physician satisfaction, and productivity. additionally, the study team intends to perform an economic evaluation analysis of the tools to guide business decision making. the study team will also analyze physician reported effects of the ai tools on patient safety, equity, and any unintended consequences of the initiative.

Eligibility criteria:
inclusion criteria: * ambulatory care physicians within the ucla health system who held at least one half-day of clinic per week exclusion criteria: * trainee providers (e.g., residents, medical students) and allied healthcare professionals (e.g., rns, pas) * attendings who work exclusively with trainees

Keywords: artificial intelligence scribe randomized controlled trial documentation efficiency physician burnout
comparison between spige and skin prick test of local and imported aeroallergens

Conditions: Immediate Hypersensitivity

Summary: the prevalence of allergic rhinitis(ar) and asthma was increased world wide. in 1998, isaac found that prevalence of ar and asthma inthailand was in moderately high group. tests for immediated reaction spt and spige, were used for evaluated sensitization of allergen in patient. they guided the investigators for proper management as well as patient education. clinician will use the result for choose allergen in case that might need immunotherapy. spt is safe and more economic for patient. specific ige has an advantage in patient who cannot withhold antihistamine prior spt. in united state had a trial of result between spt and spige for cockroach, cat, house dust mite and mold. it showed the correlation between two tests. in thailand, the investigators haven't had data about it yet.

spt and specific ige for allergens is necessary for allergen avoidance and specific immunotherapy. to have local allergen extracts will help the patients to easier get the appropriate management

Eligibility criteria:
inclusion criteria: * patient with controlled asthma and/or ar (mild to moderate severity) who were diagnosed in allergy clinic and ent clinic, siriraj hospital * spt positve one of american cockroach, house dust mite, cat, dog and mold. * patient were consented to trial. exclusion criteria: * chronic disease such as heart disease, liver, renal and severe sepsis * history of anaphylaxis * skin rash * pregnancy