Kornimate/medical-research-clean huggingface dataset:
eos® versus spiral ct technique for achieving a pelvimetry in suites of obstructed labor.

Conditions: Pregnancy

Summary: the aim of this study is to demonstrate in vivo the concordance of the imagery system eos and the spiral ct in women having had an obstructed delivery. if this concordance is demonstrated, it would allow the use of this new technique of imagery, to realize a pelvimetry during the pregnancy less irradiating for the mother, and the fetus.

the aim of this study is to demonstrate in vivo the concordance of the imagery system eos and the spiral ct in women having had an obstructed delivery. if this concordance is demonstrated, it would allow the use of this new technique of imagery, to realize a pelvimetry during the pregnancy less irradiating for the mother, and the fetus. to answer this objective, the study will be a prospective, monocentric, open clinical trial, comparing the radio-pelvimetry realized with eos technique, to the spiral ct. measures are performed in the 3 months following the obstructed delivery.

Eligibility criteria:
inclusion criteria: * patients who gave birth at the chu saint-etienne * patients having an indication of pelvimetry * patients who delivered singleton pregnancy in cephalic presentation at term * patients affiliated to a social security scheme exclusion criteria: * patients with no wish of further pregnancy * patients with another cause of dystocia during labor * patients with a significant number (\>2) of radiological examinations in the year before
a trial to evaluate para-aortic lymphadenectomy for gastric cancer

Conditions: Gastric Neoplasm

Summary: to evaluate the survival benefit of para-aortic lymphadenectomy in potentially curative gastrectomy

radical gastrectomy with regional lymphadenectomy is the only curative treatment option for gastric cancer. the extent of lymphadenectomy, however, is controversial. the two european randomized trials only reported an increase in operative morbidity and mortality, but failed to show survival benefit, in the d2 lymphadenectomy group. we conducted a randomized controlled trial to compare the japanese standard d2 and d2 + para-aortic nodal dissection.

Eligibility criteria:
inclusion criteria: - preoperatively, 1. histologically proven adenocarcinoma 2. 75 years old or younger 3. forced expiratory volume in one second ≥ 50 % 4. arterial oxygen pressure in room air ≥ 70 mmhg 5. creatinine clearance ≥ 50 ml/min 6. written consent. intraoperatively 7. macroscopic t staging is t2-subserosa, t3, or t4 8. potentially curative operation is possible 9. no gross metastasis in para-aortic nodes (frozen section diagnosis not allowed) 10. peritoneal lavage cytology is negative for cancer cells exclusion criteria: 1. carcinoma in the remnant stomach 2. borrmann type 4 (linitis plastica) 3. synchronous or metachronous malignancy in other organs except for cervical carcinoma in situ and colorectal focal cancer in adenoma 4. past history of myocardial infarction or positive results of exercise ecg 5. liver cirrhosis, or chronic liver disease with indocyanine green test ≥10%

Keywords: stomach neoplasms lymph node excision abdominal aorta
brain imaging in babies study

Conditions: Autism Spectrum Disorder; Attention Deficit Hyperactivity Disorder; Neurodevelopmental Conditions; COVID-19

Summary: the aims of the bibs study the brain imaging in babies study (bibs) aims to improve understanding of how a baby's brain develops from before birth, up until 3-4 years of age. working with children from a variety of backgrounds and communities, the investigators use a combination of state-of-the-art diagnostic tools such as mri scans alongside traditional behavioural assessments to capture the earliest information on infant brain development. the focus of the bibs study mri scanning is a safe way of producing detailed images using strong magnetic fields and radio waves. it does not use x-ray. along with learning more about brain development in general, the investigators also try to identify features that may in future help predict whether a child will or will not develop traits of conditions such as autism spectrum disorder (asd) or attention deficit hyperactivity disorder (adhd). long-term, this may help target useful interventions early on, helping children who are most in need. since covid-19 arrived in the united kingdom (u.k.) in 2020, the investigators have been given ethical approval to include testing for this infection in the mothers and children participating in the study. this may provide an opportunity to better understand how mother and baby respond to infections. the investigators particularly welcome mothers who have had a positive covid-19 test during their pregnancy to join the study.


Eligibility criteria:
inclusion criteria: * pregnant mothers with and without confirmed covid-19 * infants with and without an immediate family history of autism spectrum and neurodevelopmental conditions * based in england, uk exclusion criteria: * based on further screening
the influences of long periods of pneumoperitoneum and head up position on the variation of heart-rate corrected qt interval during robotic-assisted laparoscopic gastrectomy - observational study

Conditions: Stomach Cancer

Summary: sympathetic activity could be increased during robot-assisted laparoscopic gastrectomy, which is performed in a head up position under co2 pneumoperitoneum. stimulation of the sympathetic nervous system prolongs the qt interval and can increases the susceptibility to life threatening cardiac arrhythmias. thus the investigators decided to evaluate the heart-rate corrected qt interval (qtc interval) during robotic-assisted laparoscopic gastrectomy.


Eligibility criteria:
inclusion criteria: 1. asa class i-ii 2. obtaining written informed consent from the patients who were undergoing robot- assisted laparoscopic gastrectomy. exclusion criteria: 1. emergency operation 2. cardiac disease (unstable angina, congestive heart failure, valvular heart disease) 3. ventricular conduction abnormality 4. prior pacemaker insertion 5. abnormal electrolyte values 6. patients who take antiarrythmic agent 7. hepatic or renal failure 8. drug hyperactivity 9. neurological or psychiatric illnesses
investigating the influence of age and saliva flow on the perception of protein fortified foods and beverages

Conditions: Individual Difference; Food Sensitivity; Food Preferences

Summary: brief summary: this study aims to investigate whether protein fortification of foods and beverages causes mouthdrying and mucoadhesion and whether this is influenced by age and saliva flow.

to investigate whether whey protein beverages cause mouthdrying in older adults and if perception and acceptance are influenced by repeated consumption, age and individual differences in saliva flow. to investigate whether protein fortification of cupcakes causes mouthdrying and if perception and acceptance are influenced by repeated consumption, age and individual differences in saliva flow in a home environment. to investigate whether mucoadhesion is present within different food models, if sensitivity to mucoadhesion increases with age and to determine if a reduced salivary flow results in strengthened mucoadhesion.

Eligibility criteria:
inclusion criteria: * age (18-30 years or over 65 years) * healthy exclusion criteria: * cognitively impaired * allergies, intolerance and special dietary requirements (for example coeliac disease, lactose / gluten intolerance) * suffer from diabetes * oral surgery * stroke * smoker * cancer

Keywords: older adults oral nutritional supplements saliva flow mucoadhesion mouthdrying
training in a local community aimed upon musculoskeletal health promotion for postmenopausal women

Conditions: Age-Related Osteoporosis

Summary: to minimize fracture risk, diverse and varied training of high intensity (multimodal training) is recommended to increase bone strength. however, the effectiveness of different training programmes performed in community settings remain uncertain. the present study aimed to evaluate the feasibility and the effectiveness of 19-week of multimodal training in a local community center in copenhagen, denmark. the health promotion initiative had special emphasis on musculoskeletal health in postmenopausal women.

a local community center was offering supervised multimodal training (mmt) to postmenopausal, healthy women twice weekly, and the aim of the present study was to evaluate the feasibility and the musculoskeletal health promoting effects of the training. the evaluation study lasted for 19 weeks, and the average attendance rate of mmt participants had to be \> 1 hour weekly. the primary outcomes were bone mineral density (bmd) assessed by dual-energy x-ray absorptiometry (dxa) scanning and the fasted plasma concentration of bone turnover markers (btm): n-terminal propeptide of type i procollagen (p1np) , c-terminal telopeptide of type i collagen (ctx), osteocalcin), while secondary outcomes were body composition variables, dynamic postural balance and functional muscle strength. to test within- and between-group differences in the pre and post outcomes the training group (mmt) was compared with a sedentary control group (con). every participant was fully informed before giving her written informed consent to the procedures and potential discomfort associated with the study. the study was conducted in accordance with the declaration of helsinki and approved by the local ethics committee of the capital region of denmark, h-18044190.

Eligibility criteria:
inclusion criteria: * past menopause * non-smoking * bmi \<30 kg/m2 exclusion criteria: * t-score \< -3 sd in the lumbar spine or hip * z-score \> 1.5 sd) * use of hormone therapy, medical treatment or supplements that affect bone metabolism * previous or current medical condition affecting bone health * engagement in regular and systemic weight-bearing training or strength training during the preceding two years

Keywords: bone mineral density bone turnover marker high-impact odd-impact resistance exercise menopause health promotion
evaluation of fb-401 in children, adolescents and adults (2 years and older) with mild to moderate atopic dermatitis

Conditions: Atopic Dermatitis

Summary: the purpose of this study is to evaluate the potential improvement in atopic dermatitis signs and symptoms following the application of fb-401 in patients 2 years or older with mild to moderate atopic dermatitis. fb-401 will be applied topically for 16 weeks and progress will be assessed by assessment of the skin and patient reports.


Eligibility criteria:
inclusion criteria: * male or female, ≥ 2 years of age * clinical diagnosis of atopic dermatitis as defined by hanifin and rajka criteria that has been present for ≥ 3 months before the screening visit * investigator global assessment (iga) score of 2 (mild) or 3 (moderate) at screening and baseline/day 1 using the validated iga scale for atopic dermatitis * easi score ≥ 5 at the screening and the baseline visit * 5% to 30% (inclusive) body surface area of atopic dermatitis involvement at the screening and the baseline visit exclusion criteria: * previous treatment within 4 weeks prior to the baseline visit with any of the following: * immunosuppressive or immunomodulating systemic drugs such as systemic (intravenous, oral, intra-articular or intramuscular) corticosteroids, azathioprine, methotrexate, cyclosporine * phototherapy or photo chemotherapy for atopic dermatitis * previous treatment within 1 week prior to the baseline visit with any of the following: * topical corticosteroids (does not include inhaled, intranasal or ophthalmic) or topical calcineurin inhibitors * topical phosphodiesterase type 4 (pde4) inhibitor * use of emollients other than provided for the study * bleach baths * within 8 weeks or 5 half-lives (if known), whichever is longer, prior to the baseline visit with janus kinase inhibitors or other investigational drug * within16 weeks or 5 half-lives, whichever is longer, prior to the baseline visit with dupilumab or other biologic agent to treat atopic dermatitis * within 1 year prior to the baseline visit with any live bacterial therapy * pregnant (or planning to become pregnant during the period of the study) or lactating females

Keywords: atopic dermatitis microbiome probiotic commensal gram-negative bacteria transdermal water loss allergic diseases dermatitis eczema skin diseases skin diseases, eczematous immune system diseases
spine surgery video observation study. the creation of a benchmark video (rgb-depth) dataset to investigate the feasibility of developing a markerless tracking system for spine surgery.

Conditions: Spine Fusion; Spine Injury; Spine Degeneration; Navigation, Spatial

Summary: the primary study objective is to build a video dataset, consisting of both colour and depth information, of spine surgery that includes both 'open' and 'minimally invasive' (mis) surgeries. using accompanying preoperative ct scans of the patient's spine, we aim to develop a markerless tracking system for spine surgery, which the collected dataset will be used to both train, and then benchmark against.


Eligibility criteria:
inclusion criteria: * candidate surgeries include all spine surgeries taking a posterior approach. this includes both 'open' and 'minimally invasive' surgeries, provided some portion of vertebrae bone is exposed. exclusion criteria: * candidate surgeries will be excluded if the patient is under the age of 18 or the clinical lead feels the patient lacks capacity to consent.

Keywords: imaging depth imaging spine surgery intraoperative registration
the effect of individualized education using the teach-back method treatment on treatment adherence and the coping skills

Conditions: End Stage Renal Disease on Dialysis

Summary: this study was planned to evaluate the effect of individual education given to adult patients with end stage renal disease receiving hemodialysis treatment, using the roy adaptation model-based teach back method under the guidance of nurses, on their ability to cope with fluid, diet and medication compliance and their adaptation skills.

the study is a randomized, controlled, two-group intervention trial with pretest-posttest design at three centers. the study will enroll adult end stage renal disease patients receiving hemodialysis treatment who meet the inclusion criteria at the three centers where the study is being conducted. data for the study will be collected using face-to-face interviews, a patient information form, a hemodialysis treatment information form, the end-stage renal disease adherence questionnaire, a coping and adaptation processing scale, and a "teach back method" questionnaire. patients participating in the study will receive an educational booklet that will be completed after obtaining expert opinion based on the literature from the researcher. patients in the intervention group will be trained by the researcher using the "teach back method" in three sessions. each session will last 45-60 minutes. from the 2nd week of the study, patients' questions will be answered and a 15-minute retraining session will be made in every two weeks. patients in the control group will undergo a pretest and a posttest, and their routine care and treatment will continue. at the end of the study, patients in the control group will take training booklets.

Eligibility criteria:
inclusion criteria: * hemodialysis treatment for 4 hours, three times a week for at least 3 months with a diagnosis of end-stage renal failure, * individuals between the ages of 18 and 65 years, * having no speech, vision or hearing problems, * be able to speak, read and write in turkish, * patients who have voluntarily to participate and informed consent form in the study. exclusion criteria: * those who do not participate or agree to participate in training, * the general situation is not suitable for questioning, * those diagnosed with a cognitive disease such as dementia.

Keywords: hemodialysis end-stage renal failure treatment adherence fluid and dietary restrictions teach-back method
ibi376 in patients with relapsed or refractory follicular lymphoma/marginal zone lymphoma

Conditions: Indolent Non-hodgkin Lymphoma

Summary: a phase 2, multicenter, open-label study of ibi376, a pi3kδ inhibitor, in patients with relapsed or refractory follicular lymphoma/marginal zone lymphoma

patients will be recruited for 2 cohorts. cohort a will recruit 58 rrfl subjects, and cohort b will recruit 62 rrmzl subjects.

Eligibility criteria:
inclusion criteria: 1. aged 18 years or older. 2. histologically confirmed, relapsed or refractory, follicular b-cell non-hodgkin lymphoma (nhl) (fl) grade 1, 2, and 3a or mzl. 3. ineligible for hematopoietic stem cell transplant. 4. definition of rrfl or rrmzl: subjects should have received 2 or more prior therapies for fl/mzl included at least one regimen containing rituximab. subjects should be refractory to rituximab or experienced disease progression after achieved remission or disease progression within 6 months since last therapy. 5. radiographically measurable lymphadenopathy or extranodal lymphoid malignancy (defined as the presence of ≥ 1 lesion that measures \> 1.5 cm in the longest dimension and ≥ 1.0 cm in the longest perpendicular dimension as assessed by computed tomography (ct) or magnetic resonance imaging (mri). 6. subjects must be willing to undergo an incisional, excisional, or core needle lymph node or tissue biopsy or provide a lymph node or tissue biopsy from the most recent available archival tissue. 7. ecog performance status 0 to 2. 8. life expectancy ≥ 12 weeks. 9. adequate hematologic, hepatic, and renal function. 10. willingness to avoid pregnancy or fathering children. exclusion criteria: 1 . known histological transformation from indolent nhl to diffuse large b-cell lymphoma. 2. history of central nervous system lymphoma (either primary or metastatic). 3. prior treatment with idelalisib, other selective pi3kδ inhibitors, or a pan-pi3k inhibitor. 4. prior treatment with a bruton's tyrosine kinase inhibitor (eg, ibrutinib). 5. allogeneic stem cell transplant within the last 6 months, or autologous stem cell transplant within the last 3 months before the date of study treatment administration. 6. active graft-versus-host disease. 7. subjects positive for hepatitis b surface antigen or hepatitis b core antibody will be eligible if they are negative for hbv-dna. subjects positive for anti-hcv antibody will be eligible if they are negative for hcv-rna.

Keywords: follicular lymphoma marginal zone lymphoma parsaclisib
efficacy of risk-stratified treatment in newly diagnosed infant leukemia

Conditions: Leukemia, Lymphoid

Summary: this clinical trial is an open-label, multicenter, prospective phase 2 clinical trial targeting pediatric leukemia patients of infant age. the goal is to improve survival rates by varying the presence or absence of chemotherapy and hematopoietic stem cell transplantation based on genetic characteristics at the time of diagnosis and minimal residual disease (mrd) values measured by various methods after treatment. in addition, by clearly defining the patient group that requires hematopoietic stem cell transplantation, it is expected that the role of hematopoietic stem cell transplantation in infantile leukemia, for which there have been various guidelines for hematopoietic stem cell transplantation, can be confirmed. additionally, due to the characteristics of infants, this study aim to identify long-term sequelae or prognosis related to treatment by prospectively collecting side effect data related to treatment during and after treatment.

infant leukemia patients are classified into low/intermediate/high risk groups and hematopoietic stem cell transplantation is performed after chemotherapy or chemotherapy as shown in the schema below. * low risk group : induction chemotherapy-low risk consolidation chemotherapy 1\~4 - maintenance chemotherapy * intermediate risk group : induction chemotherapy-high risk consolidation chemotherapy 1\~4 - maintenance chemotherapy * high risk group : induction chemotherapy-high risk consolidation chemotherapy 1\~4 - hematopoietic stem cell transplantation

Eligibility criteria:
inclusion criteria: * the age of diagnosis is less than 1 year old * the disgnosisi of all or alal(lymphoid predominant) * informed consent of the parents(guardians) before participation in this study exclusion criteria: * burkitt leukemia/lymphoma or mature b-cell leukemia * down syndrome, bloom syndrome, ataxia-telangiectasia, fanconi anemia, kostmann syndrome, shwachman syndrome or other bone marrow failure syndrome, hematopoietic stem cell transplantation * relapsed infant leukemia * participants with contraindication to medication * administered systemic steroid therapy within 4 weeks prior to this study * participants in other interventional studies other than this protocol
core stability, symmetrical weight-bearing stroke

Conditions: Stroke

Summary: to evaluate the effect of core stability exercise on symmetrical weight bearing in chronic stroke patients?

stroke is a syndrome characterized by quickly emerging clinical indicators of a focal (or global) disruption of brain function. the symptoms can last for more than 24 hours or even result in death, and there is no known reason for them other than vascular origin. over 80% of all strokes are caused by an ischemic stroke. a large artery blockage typically results in tissue infarction, which is the non-selective loss of all brain cells in the affected areas of the brain if it is not quickly reversed. determining the location and size of these infarcts is crucial. the long-term functional deficits resulting from ischemic stroke. after a stroke, patients' ability to bear weight symmetrically is similarly compromised; they may bear between 61 and 80% of their body weight on a non-paretic leg. physiotherapy procedures targeted at enhancing core stability can enhance the lumbopelvic-hip musculature's strength, coordination, and endurance, potentially reducing physical deficits linked to compromised trunk function. because these muscles are crucial for both stability and lumbar posture control (by the employment of core stability is commonly utilized in whole-body exercises to enhance the strength of the muscles around the stomach, lumbar, and pelvic regions, whether they be tonic or postural muscles. the trunk is the body's center pivot point, serving as a vital component for functional activity, balance, postural control, and extremity coordination. consequently, the trunk is very important. in the recovery procedure. there is a substantial body of research demonstrating that trunk control, balance when sitting and standing, and mobility can all be improved with trunk training. in stroke patients, according to recent studies in systemic reviews. so, the purpose of the current study was to detect the effect of core stability exercise on symmetrical weight bearing in patients with chronic stroke

Eligibility criteria:
inclusion criteria: 1. forty hemiparetic patients were diagnosed and referred to by a neurologist. 2. all patients must be ambulant 3. the spasticity of lower limbs ranges from (grade 1: 1+) according to modified ashworth scale. 4. patients with sufficient cognitive abilities that enables them to understand and follow instructions (mini-mental scale \>24). ( 5. age ranges from 50 to 65 years in both sexes. 6. duration of stroke was more than 6 months up to 24 months. - exclusion criteria: * the patients were excluded if they had any of the following: 1. musculoskeletal disorders such as severe arthritis grade (3-4) of osteoarthritis, lower limb fractures less than 6 months or contractures of fixed deformity. 2. cognitive impairment (a score less than 24 according to the mmse) 3. patients with diabetic neuropathy. 4. recurrent stroke. 5. rheumatologic or endocrinologic disorders that may cause rom restriction. 6. patients suffering from cognitive, or emotional disturbance.