Kornimate/medical-research-clean huggingface dataset:
warfarin - how good are we at maintaining target range ?

Conditions: Atrial Fibrillation

Summary: patients with atrial fibrillation are often anticoagulated with warfarin. warfarin has a narrow therapeutic window requiring frequent monitoring. this study aims to investigate the incidence of adverse events in the "real world" for patients receiving warfarin for lone atrial fibrillation.


Eligibility criteria:
inclusion criteria: * prescription for warfarin * atrial fibrillation exclusion criteria: * other conditions associated with increased risk of embolisation e.g. rheumatic valve disease, atrial mixoma. * conditions with increased risk of bleeding.

Keywords: atrial fibrillation warfarin safety
noninvasive high frequency oscillatory ventilation as a post-extubation respiratory support in neonates

Conditions: Infant, Premature, Diseases; Infant, Newborn, Disease; Respiratory Tract Diseases; RDS

Summary: a randomized controlled trial comparing noninvasive high frequency oscillatory ventilation (nhfov) and noninvasive positive pressure ventilation (nippv) as post-extubation respiratory support in preterm neonates with respiratory distress syndrome(rds)

the use of noninvasive respiratory support (nrs) has increased in recent decades in neonatal intensive care unit (nicu) as a means to reduce ventilator-induced lung injury. various modes of nrs are available and in common use. however despite extensive research, the optimal modality of noninvasive modes remain unknown. noninvasive high-frequency oscillatory ventilation (nhfov) is a relatively new mode. it consists of the application of a continuous distending positive pressure with superimposed oscillations. it is a method of augmenting continuous positive airway pressure (cpap) support potentially combining the advantages of both high-frequency oscillatory ventilation and cpap. the new nhfov technique offers improved carbon dioxide (co2) removal and increased functional residual capacity. the superimposed oscillations of nhfov are thought to help avoid gas trapping and upregulate mean airway pressure. this technique is also characterized by lower tidal volume resulting in fewer barotraumas /volutraumas and not needing synchronization. nhfov was considered a strengthened version of cpap. the hypothesis is that nhfov might be superior to nippv as a post-extubation respiratory support strategy to avoid reintubation and subsequent complications and/or sequelae in preterm infants.

Eligibility criteria:
inclusion criteria: 1. preterm neonates with gestational age ≤ 35 weeks. 2. neonates that were on invasive mechanical ventilation for at least 48 hours eligible for extubation exclusion criteria: 1. patients with major upper or lower airway anomalies. 2. patients with significant congenital anomalies including cardiac, abdominal or respiratory.

Keywords: noninvasive high frequency ventilation noninvasive ventilation rds post-extubation preterm respiratory distress syndrome noninvasive positive pressure ventilation
natural course of adhesive capsulitis of hip

Conditions: Adhesive Capsulitis

Summary: the purpose of this prospective study is to see the natural course of adhesive capsulitis of hip. the study is based on the hypothesis that the natural course of adhesive capsulitis of hip is similar to that of adhesive capsulitis of shoulder. this study is also based on a hypothesis that hip joint capsule stretching exercise will result in pain relief, recovery of hip range of motion in months.


Eligibility criteria:
inclusion criteria: * painful hip with limited range of motion (especially external rotation and abduction) exclusion criteria: * acute trauma history * hematologic abnormality (rheumatologic disease, autoimmune disease) * radiologic abnormality (joint degenerative change, calcification, loosebody, evidence of femoroacetabular impingement, osteonecrosis of femoral head, etc) * mri: extra-articular pathology

Keywords: adhesive capsulitis hip
brain oxygenation monitoring in patients undergoing coronary artery bypass surgery

Conditions: Neurological Manifestations

Summary: the purpose of this study is to determine whether intraoperative brain oxygenation monitoring in cardiac surgery patients is effective in reducing postoperative neurologic and neurocognitive dysfunction.

this study represents a prospective, randomized assessment of the potential clinical and economic benefit to be derived from the continuous non-invasive monitoring of regional cerebral oxygen saturation (rso2) during cardiac surgery employing cardiopulmonary bypass (cpb). previous studies have shown that low rso2 values obtained during surgery are highly associated with postoperative frontal lobe dysfunction, cognitive declines, disorientation, and other clinical indices of prolonged recovery. low rso2 values are thought to reflect the development of tissue hypoxia within susceptible regions of the cerebral cortex during the non-pulsatile perfusion of cpb. rapid detection and correction of such episodes should help avoid regional hypoxia and its attendant postoperative sequelae. this study will assess neurologic, psychometric, and quality of life markers of brain dysfunction which could result from cpb. each study patient will be assessed both pre- and postoperatively (pre-hospital discharge and at three months) for neurologic and neurocognitive dysfunction. comparison(s): intervention versus control group. patients assigned to the intervention rso2-monitored group will be managed with conservative measures designed to maintain the rso2 value at, or above, its preoperative value. such measures include increases in pump flow, blood pressure, anesthetic dose, arterial oxygen tension, carbon dioxide tension, and hematocrit. those patients in the control group will be managed according to current established practice. although rso2 is also recorded in this group, the monitor's readings are blinded.

Eligibility criteria:
inclusion criteria: * primary coronary artery bypass surgery * ages 18-90 * voluntary participation with signed informed consent exclusion criteria: * an unwillingness to participate in the study * inability to obtain informed consent * expressive or receptive aphasia * inability to correctly perform the neurocognitive tests preoperatively * inability to correctly perform the saccadic and anti-saccadic eye movement tests preoperatively * non-english speaking candidates * patients for whom it is known that follow-up will be improbable * previous cardiac surgery * concomitant procedures * pre-existing psychotic disorders * patients with active alcohol (etoh) abuse requiring emergent surgery * patients scoring 2 or higher on the cage evaluation * mini-mental state exam preoperative score of 23 or less * severe visual or auditory disorders * parkinson's disease

Keywords: cardiac surgery cardiopulmonary bypass cerebral oxygenation neurologic dysfunction neurocognitive dysfunction neurological manifestations memory loss delirium coronary artery bypass
study comparing etanercept with usual dmard therapy in subjects with rheumatoid arthritis in the asia pacific region

Conditions: Rheumatoid Arthritis

Summary: the purpose of this study is to compare the efficacy of etanercept with usual disease-modifying anti-rheumatic drug (dmard) therapy in the treatment of moderate to severe rheumatoid arthritis (ra) over 16 weeks in the asia pacific region.


Eligibility criteria:
inclusion criteria: * diagnosis of ra * currently receiving an adequate dose of methotrexate (mtx) for treatment of ra * active ra at time of screening and baseline exclusion criteria: * previous or current treatment with etanercept (etn), other tumor necrosis factor-alpha inhibitors, or other biologic agents * concurrent treatment with a dmard, other than mtx, at screening * receipt of any dmard, other than mtx, within 3 months before screening
hipec surgery and hemodynamics

Conditions: Hemodynamics; Cytoreductive Surgery; Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

Summary: hyperthermic intraperitoneal chemotherapy (hipec) involves the intraoperative administration of heated chemotherapeutic agents into the abdominal cavity following cytoreductive surgery (crs). the increasing use of crs combined with hipec has introduced certain procedural and physiological considerations that distinguish it from other surgical interventions, posing unique challenges for researchers and clinicians alike. despite advancements in surgical and anesthetic techniques, this combined approach is frequently associated with significant hemodynamic instability, coagulation abnormalities, respiratory complications, and nutritional imbalances. the study aims to contribute to the existing body of knowledge by examining the physiological alterations induced by hipec, thereby offering practical insights and guidance for investigators involved in the management and study of this complex therapeutic modality.


Eligibility criteria:
inclusion criteria: * ≥18 years old patients planned to undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy * asa ii-iii-iv physical class exclusion criteria: * \<18 years * emergency cases

Keywords: hi̇pec cytoreductive surgery hemodynamics
biology of thymic tumors

Conditions: Thymoma

Summary: this is a retrospective analysis of biological characteristics of thymoma and thymic carcinoma patients.

the aim of the present study is to investigated the genetic alterations in tumor samples of a series of all who-defined subtypes of thymoma patients using high resolution microarray- comparative genomic hybridization (cgh) followed by hierarchical cluster analyses of the data to identify specific patterns of genetic aberrations and genes associated with each subtype. moreover, tumor samples will be also investigated for some specific potential therapy targets by immunoistichemistry, mutation analysis, and fluorescence in situ hybridization (fish) analysis. all these biological data will be correlated with clinical patients characteristics and survival data.

Eligibility criteria:
inclusion criteria: * availability of tumor tissue and patients with thymoma and thymic carcinoma exclusion criteria: * non availability of tumor tissue and patients with thymoma and thymic carcinoma
the effect of stretching and relaxation exercises on anxiety in individuals with fibromyalgia

Conditions: Fibromyalgia

Summary: fibromyalgia is a non-articular, chronic rheumatic disease of unknown etiology characterized by widespread musculoskeletal pain, sleep disturbance, fatigue, and the presence of multiple tender points.

although the exact etiology cannot be determined in fibromyalgia, it is thought that there are many mechanisms that contribute to the formation of fibromyalgia. evidence for some biochemical, neurohormonal, central nervous system, immunological, psychological and environmental factors that may play a role in the disease has been found.

Eligibility criteria:
inclusion criteria * volunteer * being diagnosed with fibromyalgia exclusion criteria * known neurological disorder * serious orthopedic disorders that will prevent him from exercising * cognitive impairment * using regular nsaids * being malnourished and malnourished

Keywords: exercise
impact of different hemostasis methods on ovarian function and fertility during laparoscopic ovarian cystectomy of benign ovarian cyst

Conditions: Ovarian Cyst Benign

Summary: the purpose of this study is to compare the impact of different hemostasis methods during laparoscopic ovarian cystectomy on ovarian function and fertility in women with benign ovarian cysts.


Eligibility criteria:
inclusion criteria: 1. women diagnosed with benign ovarian cysts requiring surgical management. 2. women who choose laparoscopic ovarian cystectomy voluntarily sign a surgical consent form. 3. women participating in this study recognize three hemostatic methods and are ready to randomly accept one of them. 4. women aged between 18 and 40 years old. 5. it was diagnosed by ultrasound as unilateral or bilateral benign ovarian cysts with a maximum diameter of 4-8cm. the nature of the cysts is ultimately confirmed by postoperative pathological examination. 6. women with no previous history of ovarian surgery, chemotherapy, or pelvic radiation therapy. 7. patients with no history of endocrine disorders such as hyperprolactinemia, hypothyroidism, or hyperthyroidism, and no history of endocrine therapy within 6 months before laparoscopic ovarian cystectomy. exclusion criteria: 1. polycystic ovary syndrome. 2. pregnancy or lactation period. 3. women with active pelvic inflammatory disease, genital or extragenital malignant tumors. 4. women who have undergone two or more pelvic or abdominal surgeries. 5. evidence of premature ovarian failure or premature menopause, such as amh\<1ng/ml. 6. conversion to open surgery. 7. women who refuse to sign informed consent or are unable to attend follow-up regularly. 8. cysts that do not originate from the ovaries or have the characteristics of malignant tumors.
combined treatment with tnf inhibitor and pamidronate in as patients: effect on the radiographic progression

Conditions: Ankylosing Spondylitis

Summary: it will be a pilot, 2 year, prospective, randomized, double-blind, placebo-controlled (for pamidronate) study. all patients with as will receive treatment with tnf inhibitor, while randomization will be performed for pamidronate versus placebo group. primary outcome will be the rate of radiographic progression of as, calculated after 24 months of combined treatment.

it will be a pilot, 2 year, prospective, randomized, double-blind, placebo-controlled (for pamidronate) study. all patients with as will receive treatment with tumor necrosis factor (tnf) inhibitor, as indicated by local guidelines. randomization will be performed for pamidronate vs placebo group. pamidronate will be prescribed as monthly intravenous infusion in the dose of 60 mg/month for the first 6 consecutive months of every study year. primary outcome will be the rate of radiographic progression of ankylosing spondylitis (as), calculated after 24 months of combined treatment. clinical and laboratory disease parameters will serve as secondary outcomes. these outcomes as well as safety assessments will be performed on a monthly basis up to 24 months.

Eligibility criteria:
inclusion criteria: * presence of spinal syndesmophytes * normal renal and liver function * eligibility to receive anti-tnf treatment according to local guidelines exclusion criteria: * unwilling to sigh the informed consent * presence of significant systemic or organ-limited disorders, other than as * any contraindication for anti-tnf or pamidronate treatment * presence of acute dental/periodontal disease
trial to evaluate a specified type of apgar (test-apgar) follow up study

Conditions: Premature Birth; Mortality; Apgar Score

Summary: a specified version of the apgar-score, that can be used in newborns under resuscitation, was developed and its value to predict chronic damage in preterm infants will be tested.

specifications of the individual items of the original apgar score were suggested. these specifications slightly changed the apgars' perspective, but did not alter the number of its components. the specified apgar should therefore be easily applicable to every delivery room around the world. as a result of these specifications, the apgar score will not express the efforts of the infant but describe its condition, independently of the requirements needed to achieve this condition. the advantage of the proposed definitions is the applicability in all infants, regardless of resuscitative efforts or gestational age. to validate the accuracy of the specified version to predict neonatal mortality and long term neurological outcome in preterm infants the present prospective, observational study is planned. the study will test the hypothesis that the specified apgar-score predicts mortality and morbidity better at 2 years of age than the conventional apgar-score. furthermore, the predictive reliability of the specified apgar can be improved in combination with perinatal data respectively with the expanded apgar version of the aap/acog. the primary outcome "condition at 2 years of age" is composed of death and a major neurological deficit. in this case "neurological deficit" is defined by the presence of one of the followings characteristics: index of mental development (bayley scale ii) \<85, blindness, deafness, cerebral palsy.

Eligibility criteria:
inclusion criteria: * all preterm infants included in the test-apgar study exclusion criteria: * missing parental consent

Keywords: neurodevelopmental impairment intraventricular hemorrhage retinopathy of prematurity mortality apgar score
compound phellodendron decoction may promote wound healing after anal fistulotomy

Conditions: Fistula in Ano

Summary: sitz-bath therapy with chinese medicine has significant advantages in the management of postoperative wounds of anal fistula. this method not only ensures safety, efficacy, and cost-effectiveness, but also simplifies application. with a firm foundation in a historical heritage, this method is notable for their minimal adverse reactions. the fumigating-washing or sitz-bath therapy with compound phellodendron decoction (cpd) for postoperative wounds of anal fistula has demonstrated efficacy in mitigating pain, reducing edema, curbing secretions, alleviating skin itching, and promoting wound healing processes. despite the body of clinical research in this domain is substantial, the majority of studies have been limited to observing therapeutic outcomes. the intrinsic mechanisms by which these effects are achieved remain elusive. this study aims to unravel the potential mechanisms underpinning cpd's promotion of wound healing, focusing on the aspects of inflammation and immunity.


Eligibility criteria:
inclusion criteria:age range of 18 to 80 years who had undergone anal fistulotomy procedures. - exclusion criteria:patients with crohn's disease, pregnancy or lactation, organ dysfunction (such as heart failure, respiratory insufficiency, liver or renal impairment, gastrointestinal dysfunction), coagulopathy, autoimmune diseases, or a history of hypersensitivity to chinese medicinal substances. -

Keywords: anal fistula
efficacy and safety of fluvastatin or valsartan and their combination in dyslipidemic patients with hypertension and endothelial dysfunction

Conditions: Hypertension; Dyslipidemia

Summary: patients with mild to moderate hypertension, dyslipidemia (imbalanced blood lipids) and decreased vascular dilatation, receiving a cholesterol lowering diet were given either valsartan or fluvastatin for 8 weeks. at week 8 all patients were administered a combination treatment with valsartan 160 mg and fluvastatin 80 mg.


Eligibility criteria:
inclusion criteria: * arterial hypertension * dyslipidemia * cholesterol lowering diet exclusion criteria: * constant antihypertensive treatment * diabetes mellitus * myocardial infarction or stroke in the previous 3 months other inclusion and exclusion criteria may apply

Keywords: arterial hypertension dyslipidemia valsartan fluvastatin
empirical rescue therapies of helicobacter pylori infection

Conditions: Functional Dyspepsia; Scarred Peptic Ulcer

Summary: the increase of antibiotic resistance to h. pylori causes failure of treatment. furazolidone, amoxicillin and tetracycline are good candidates for rescue therapy since resistance to these three antimicrobials was rare. it is necessary to assess the efficacy and safety of these four bismuth-containing quadruple regimens with above antibiotics as empirical rescue therapies for h. pylori eradication.


Eligibility criteria:
inclusion criteria: * h. pylori -positive patients with functional dyspepsia and scarred peptic ulcers who had previously failed one or more eradication regimens containing clarithromycin, metronidazole and/or amoxicillin. exclusion criteria: * less than 18 years old, never receiving eradication treatment before, with previous gastric surgery, pregnancy, lactation, major systemic diseases, administration of antibiotics, bismuth, antisecretory drugs in the preceding 8 weeks
quadratus lumborum block vs erector spinal block for post abdomen surgery analgesia

Conditions: Pain, Acute; Postoperative Pain; Anesthetics, Local

Summary: the erector spinal block (esp) is based on the deposition of the local anesthetic in the inter-fascial space between the dorsal extensor muscle and the intercostal muscles at the height of the transverse processes. the scope of the blockade covers the dorsal and ventral branches of the thoracic spinal nerves, but also in most cases the investigetors are able to obtain a wide distribution of the drug into the paravertebral space by "permeating" the local anesthetic through the fascial compartments. the clinical effect of the blockade is due to blocking the nerve structures of the paravertebral space (spinal nerve branches and the sympathetic trunk). the scope of the blockade, after its execution at the level of th5, most often includes the segments from th1 to l1. currently, the quadratus lumborum block (ql block) is performed as one of the perioperative pain management procedures for all generations (pediatrics, pregnant, and adult) undergoing abdominal surgery. the local anesthetic injected via the approach of the posterior ql block ( ql 2 block ) can more easily extend beyond the tap to the thoracic paravertebral space or the thoracolumbar plane, the posterior ql block entails a broader sensory-level analgesic and may generate analgesia from t7 to l1. use of posterior ql block in laparoscopic prostatectomy has not been investigated before and it is the variant that will be discussed in our study.

in abdomen surgery, overall pain is a conglomerate of three different and clinically separate components: incisional pain (somatic pain), visceral pain (deep intra abdominal pain), and shoulder pain due to peritoneal stretching and diaphragmatic irritation associated with carbon dioxide insufflation. moreover, it has been hypothesized that intense acute pain after labdomen surgery may predict development of chronic pain. without effective treatment, this ongoing pain may delay recovery, mandate inpatient admission, and thereby increase the cost of such care.

Eligibility criteria:
inclusion criteria: * patients requiring abdomen surgery * patients of age 18 and over * bmi \< 40 * patients who are expected to stay in-hospital overnight after surgery exclusion criteria: * patient refusal * contraindications to paravertebral blocks: infection at the site of needle insertion, empyema, allergy to local anesthetic drugs, and tumor occupying the thoracic paravertebral space, coagulopathy, bleeding disorder or therapeutic anticoagulation * known allergy to local anesthetics * inability to provide informed consent * inability to use a pca due to languate or comprehension barriers * bmi \>= 40 * any patient on opioids for greater than or equal to 3 months duration prior to surgery * patients with chronic pain syndromes

Keywords: anesthetics local anesthetics