Kornimate/medical-research-clean huggingface dataset:
longitudinal evaluation of the impact of parenteral nutrition

Conditions: Parenteral Nutrition

Summary: patients with type 3 intestinal failure are completely reliant on artificial feeding and often manage this at home; home parenteral nutrition (hpn). hpn therapy is life saving for these patients. the parenteral nutrition impact questionnaire (pniq) is a proven tool for measuring quality of life when receiving hpn. this study will recruit hpn patients across the united kingdom (uk) and ask them to complete the pniq survey at several different time points. this will assess the impact of hpn over time. family members involved in the participants hpn care will also be asked to complete a carer burden survey (at one time point) to assess the impact of hpn on carers.

providing a person with food through a vein is known as parenteral nutrition (pn) or artificial tube feeding. this process is used when nutrients from food can't be taken in by the intestine (intestinal failure). patients with type 3 intestinal failure are completely reliant on artificial feeding and often manage this at home; home parenteral nutrition (hpn). hpn therapy is life saving for these patients. it is important to assess patients quality of life and their own reported effects of the hpn. the parenteral nutrition impact questionnaire (pniq) is a proven tool for measuring quality of life when receiving hpn. a recent study involving the use of the pniq in multiple hospitals in the uk, showed that those on fewer nights of hpn had better quality of life than those on more nights of hpn. whilst this was useful for looking at quality of life at one time point, it is now important to assess change in quality life over time and any impact on family members quality of life. this study will recruit hpn patients across the uk and ask them to complete the pniq survey at several different time points. this will assess the impact of hpn over time. family members involved in the participants hpn care will also be asked to complete a carer burden survey (at one time point) to assess the impact of hpn on carers. the study is being funded by shire pharmaceuticals ltd.

Eligibility criteria:
inclusion criteria: patients: * all people in receipt of hpn including new patients * those 18 years and over. carers: * a family member or person involved in the healthcare of the participating patient. (we will ask patients to nominate their closest family member who in their opinion is potentially most effected by the parenteral feeding.) * those 18 years and over. exclusion criteria: patients: * cannot give informed consent * cannot read or write in english. carers: • family members not directly involved with caring for participants

Keywords: intestinal failure quality of life carer burden
deep brain stimulation of the superolateral branch of the medial forebrain bundle (slmfb) for the treatment of refractory major depression

Conditions: Major Depression

Summary: the investigators will investigate in a sham controlled staggered onset design antidepressant effects and safety of deep brain stimulation (dbs) to the superolateral branch of the main medial forebrain bundle (slmfb).

the target point for dbs in major depression disorder is located lateral to the ventral tegmental area (vta) in the midbrain at the branching point of the superolateral branch (slmfb) from the main medial forebrain bundle (mfb). the exact stimulation coordinates are: montreal neurologic institute brain 152 coordinates (mni152 coordinates): left: x(lat.)=-5, y(ap)=-14, z(vert.)=-8 right: x(lat.)=5, y(ap)=-14, z(vert.)=-9 mid-commissural point coordinates (mcp coordinates): eft: x(lat.)=-6, y(ap)=-1, z(vert.)=-6 right: x(lat.)=4, y(ap)=-1, z(vert.)=-7 all coordinates refer to the mni152 brain. legend: slmfb = superolateral branch of medial forebrain bundle lat. = lateral, ap= anteroposterior, vert. = vertical. more information can be found at: http://goo.gl/n9swv

Eligibility criteria:
inclusion criteria: * major depression (md), severe, unipolar * german mother tongue * age 20 to 75 years * hamilton depression rating scale (hrsd24) score of \> 21 * global assessment of function (gaf) score of \< 45 * at least 4 episodes of depression or chronic episode \> 2 years * failure to respond to * adequate trials (\>5 weeks at the maximum recommended or tolerated dose) of primary antidepressants from at least 3 different classes; * adequate trials (\>3 weeks at the usually recommended or maximum tolerated dose) of augmentation/combination of a primary antidepressant using at least 2 different augmenting/combination agents (lithium, t3, stimulants, neuroleptics, anticonvulsants, buspirone, or a second primary antidepressant); * an adequate trial of electroconvulsive therapy (ect) (\>6 bilateral treatments) and; an adequate trial of individual psychotherapy (\>20 sessions with an experienced psychotherapist) * able to give written informed consent * compliance to participate in the study * drug free or on stable drug regimen at least 6 weeks before study entry exclusion criteria: * current or past non-affective psychotic disorder * any current clinically significant neurological disorder or medical illness affecting brain function, other than motor tics or gilles de la tourette syndrome * any clinically significant abnormality on preoperative magnetic resonance imaging (mri) * any surgical contraindications to undergoing dbs * current or unstably remitted substance abuse (aside from nicotine) * pregnancy and women of childbearing age not using effective contraception * history of severe personality disorder * acute suicidal tendency
effects of multiple mega-dose of vitamin d3 supplementation on ameliorating moderate to severe chronic pain in hemodialysis patients

Conditions: Hemodialysis; Chronic Pain; Hyperparathyroidism

Summary: pain is a major complaint in hemodialysis (hd) patients. concentrations of parathyroid hormone (pth) \>250 pg/ml are associated with chronic pain. visual analogue scale (vas) score which is used to assess the pain severity is positively related to pth levels. this study is aimed to assess the effects of multiple mega dosages vitamin d supplementations in hd patients with chronic pain. it's a single-center, parallel, double-blind randomized control trial that administrations of 576,000 iu once a week of vitamin d3 for 4 weeks or placebo are for 120 eligible subjects. vas and laboratory tests including serum concentrations of 25(oh)d, calcium, phosphorus, pth and c-reactive protein will be evaluated.


Eligibility criteria:
inclusion criteria: 1. haemodialysis subject ≥ 20 years old 2. ipth \> 250 pg/ml 3. chronic pain with visual analogue scale (vas) score ≥ 4 4. voluntary to check serum 25(oh)d levels two times by his/her own payment during the study 5. sign the informed consent exclusion criteria: 1. used to participate in other clinical trials 2. chronic liver disease 3. sarcoidosis or multiple myeloma

Keywords: vitamin d supplementation mega-dose vitamin d cholecalciferol chronic pain
question-order effect experiment to measure hiv stigma

Conditions: HIV

Summary: question-order effect experiment to measure hiv-related stigma among people living with hiv (pwh).

hiv-related stigma is a barrier to engagement in hiv prevention and treatment. given the negative impact of stigma on the hiv continuum of care, accurate assessment of hiv-related stigma among people living with hiv (pwh) in resource-limited settings is paramount. the purpose of this study is to conduct a question order experiment to assess the extent to which the order of presented questions affects measurement of hiv-related stigma.

Eligibility criteria:
inclusion criteria: - all hiv-positive (self-reported) adults who consider nyakabare their primary place of residence and who are capable of providing consent exclusion criteria: * minors younger than 18 years of age, with the exception of emancipated minors * persons who do not consider nyakabare parish their primary place of residence, e.g. persons who happen to be visiting nyakabare at the time of the survey or who own a home in nyakabare but spend most of their time outside of the parish * persons with psychosis, neurological damage, acute intoxication, or other cognitive impairment (all of which are determined informally in the field by non-clinical research staff in consultation with a supervisor) * persons who are not hiv positive

Keywords: hiv stigma discrimination
learning from online video education for controlled ovarian stimulation

Conditions: Self Efficacy

Summary: the learning from online video education (love) study seeks to determine if online instructional videos on how to administer medication needed for in vitro fertilization (ivf) help improve the quality of life and reduce stress during the ivf process.

the learning from online video education (love) is a randomized controlled trial that seeks to determine the effect of instructional online videos on medication administration on psychological well being during controlled ovarian stimulation. the investigators hypothesize that usage of online instructional videos by women undergoing their first cycle of controlled ovarian stimulation for in vitro fertilization or oocyte cryopreservation improves measures of psychological well-being (infertility self efficacy scale, fertiqol-t and perceived stress scores) when compared to subjects that do not have access to this educational resource.

Eligibility criteria:
inclusion criteria: * undergoing first controlled ovarian stimulation cycle at the time of enrollment * has internet access exclusion criteria: * had prior controlled ovarian stimulation cycle * does not have internet access * declines in person ivf medication teaching session * treating physician requests that patient not be approached for participation (any reason)

Keywords: infertility education
a prospective study comparing two radiotherapy dose/fraction and omitting ctvs of the primary tumor in limited sclc

Conditions: Small Cell Lung Cancer Limited Stage

Summary: for most of the patients with limited-stage sclc, thoracic radiotherapy combined with chemotherapy is the standard treatment at present. however, the optimal dose / fraction of thoracic radiotherapy for limited-stage sclc is still in controversial.this study is designed as a prospecitive randomized non-inferiority trial.


Eligibility criteria:
inclusion criteria: 1. histologically/cytologically confirmed diagnosis of sclc. 2. radiologically (including brain ct/mri, chest and abdomen contrasted ct and bone scintigraphy. pet/ct is recommended) confirmed limited-stage. 3. patients should be between 18 and 75 years old. 4. ecog performance status of 0-1 (karnofsky performance status ≥ 80). 5. with adequate cardiac, pulmonary, bone marrow, hepatic and renal function. 6. with weight loss no more than 10% within 6 months before diagnosis. 7. informed consent must be signed. exclusion criteria: 1. histology confirmed the mixed nsclc components; 2. other primary malignant tumors appeared within 5 years before the first administration of the study drug, except for locally curable malignant tumors after radical treatment (such as basal or squamous cell skin cancer, superficial bladder cancer or prostate, cervical or breast carcinoma in situ, etc.); 3. any disease or condition contraindicated by radiotherapy or chemotherapy; 4. malignant pleural effusion and pericardial effusion; 5. pregnant and lactating women; 6. the investigator believes that the subject's complications or other circumstances may affect the compliance with the protocol or may not be suitable for the study.

Keywords: radiotherapy chemotherapy radiation dose radiotherapy target volume
sphenoid nasalization in allergic fungal sphenoidal sinusitis

Conditions: Fungal Sinusitis

Summary: to study the outcome of different two endoscopic sphenoid procedure for management of allergic fungal sphenoidal sinusitis : sphenoidotomy versus sphenoid nasalization with posterior septectomy .

fungal rhinosinusitis classified into invasive and noninvasive subtypes. phenotypes of noninvasive fungal rhinosinusitis occur in immunocompetent subjects and include: local fungal colonization, fungal ball, and allergic fungal rhinosinusitis. subtypes of invasive fungal rhinosinusitis include acute invasive fungal rhinosinusitis, chronic invasive fungal rhinosinusitis and granulomatous invasive rhinosinusitis. the estimated incidence of sphenoid sinusitis is only 2.7% of all nasal sinus infections, also the diagnosis of sphenoid sinus fungal infection is sometimes difficult. clinical signs are often non specific and nasal endoscopy can be strictly normal.early diagnosis is therefore difficult and diagnosis is often delayed with headache that may sometimes persists for several years before diagnosis of the disease. in most cases of sphenoid sinusitis, enlargement of the obstructed sinus ostium is sufficient to provide drainage of retained secretions and reestablish mucociliary clearance.according to simmen and jones, a type i sphenoidotomy entails identification of the ostium without further intervention; a type ii sphenoidotomy entails enlargement of the ostium upward to the level of the cranial base, and inferiorly to one-half of the sinus height; and a type iii sphenoidotomy involves widening the ostium to its most lateral extent. eloy et al in 2017 stuited that,in more extensive sphenoid sinus surgery is reserved for cases where in the disease process is extensive or previous surgery has failed. in some cases sphenoid nasalization in which bilateral extended sphenoidotomy is necessary. in this procedure, the posterior aspect of the nasal septum is resected, along with the sphenoid rostrum, the intersinus septum, and other intrasphenoid partitions, creating a common cavity with a broad drainage pathway . it also allows access to the lateral recesses of this sinus.

Eligibility criteria:
inclusion criteria: * any age. * any case of allergic fungal sinusitis unilateral or bilateral involving the sphenoid sinus exclusion criteria: * acute invasive fungal sinusitis. * previous sinonasal surgery. * unfit patient for surgery.

Keywords: sphenoid nasalization
the effect of animation-assisted information video viewing on fear and anxiety in children before endoscopy procedure

Conditions: Endoscopy; Animation; Fear; Anxiety; Child

Summary: the aim of this study was to evaluate watching video about procedure on reduce anxiety and fear in children before the endoscopy.

being admitted to a hospital is an inherently stressful event for both children and their parents, regardless of the reason in such a context where children experience multifaceted effects, it becomes imperative to ensure that their hospital experience is as positive as possible. hospitalized children often undergo medical procedures such as blood sampling, venipuncture, invasive drug administration, lumbar puncture, and intrathecal drug administration. these interventions, whether diagnostic or therapeutic, are sources of fear and anxiety for them. with a surge in gastrointestinal system disorders in children, the use of endoscopy, both as a diagnostic and therapeutic tool, has become more prevalent. pediatric nurses play a pivotal role in alleviating the fear and anxiety experienced by children and their families during medical procedures, ensuring a smoother adjustment to the process. prior research indicates that children's fear and anxiety levels significantly decrease, and parental satisfaction rises when children are informed about impending medical procedures. moreover, providing pre-procedure information has been linked to heightened treatment compliance, expedited recovery post-procedure, and a reduced reliance on analgesics. while tailored educational programs are highly effective in conveying information about medical procedures or diseases to children, their elevated cost restricts widespread implementation. traditional, cost-effective teaching strategies such as oral presentations, brochures, and booklets, although tailored for school-age children, haven't demonstrated consistent efficacy in enhancing clinical results. it has been noted that insufficient information provision can make children reliant on parents for clarification, with most procedural details tailored to parental understanding. in response, evidence-based initiatives have been introduced to enhance educational quality, boost patient clinical outcomes, and ensure cost-effectiveness. given children's developmental stage, diverse educational techniques have been employed to prepare them for medical procedures, including endoscopy. an emerging method involves utilizing cartoons, which, when effectively employed, blend entertainment with instruction.

Eligibility criteria:
inclusion criteria: * children and mothers who voluntarily participated, * who were aged 6-12 years, * who know turkish, * who do not have a vision or mental problem at a level to watch the image. exclusion criteria: * children and mothers who not voluntarily participated, * who were not aged 6-12 years, * who don't know turkish, * who have a vision or mental problem at a level to watch the image.
hemodynamics monitoring during lower body negative pressure (lbnp) induced controlled hypovolemia

Conditions: Hypovolemia; Hemodynamic Instability

Summary: to monitor the changes in central and peripheral monitors/waveforms during gradual hypovolemia induced by lower body negative pressure in healthy volunteers.

the primary aim of this research is to identify the most robust site for monitoring hypovolemia as well as assess changes in peripheral waveforms monitored by the pulse oximeter collected from different sites (finger, ear, forehead, and nose), blood pressure, cerebral oximetry and peripheral venous pressure during gradual hypovolemia induced by lower body negative pressure (lbnp) in healthy volunteers.

Eligibility criteria:
inclusion criteria: \* healthy volunteers aged 20-45 with exclusion criteria: * pregnant women * under 20 years of age * subjects with coronary artery disease, diabetes, epilepsy and hypertension
canagliflozin in patients with acute decompansted heart failure

Conditions: Chronic Heart Failure; Acute Heart Failure; Diabetes Mellitus

Summary: the study aims to investigate the efficacy and safety of the early initiation of canagliflozin treatment in hospitalized heart failure patients with volume overload (warm-wet) who require the use of i.v loop diuretic during the hospitalization period.

the study will focus on the role of adding canagliflozin to i.v loop diuretic therapy early in unstable hospitalized acute heart failure patients regardless of diabetic state, patients who will be included in the study will continue on canagliflozin for 3 months after hospital discharge to evaluate the incidence of re-hospitalization, mortality rate and other benefits related to hf symptoms will be investigated.

Eligibility criteria:
inclusion criteria: randomized within 24 of presentation during hospital admission for hypervolemic adhf with evidence of congestion defined by the presence of any of the following signs or symptoms: peripheral edema ascites jugular venous pressure \> 10 mmhg orthopnea paroxysmal nocturnal dyspnea 2.5 kg weight gain signs of congestion on chest x-ray or lung ultrasound if pulmonary artery catheterization is available pulmonary capillary wedge pressure \> 19 mmhg plus a systemic physical examination finding of hypervolemia. planned use of intravenous (iv) loop diuretic therapy during the current hospitalization estimated glomerular filtration rate (e-gfr) \> 30 ml/min/1.73 m2 based on the modification of diet in renal disease (mdrd) equation. exclusion criteria: type 1 diabetes serum glucose \ 7.3 and glucose \> 250 mg/dl and hco3 \> 18 mmol/l) in diabetic patients at the time of inclusion to the study. the use of other diuretic therapies including; ≥100 mg/day spironolactone doses, ≥ 100 mg/day eplerenone, metolazone, hydrochlorothiazide, or other thiazides, systemic acetazolamide for the indication of diuretics, triamterene, or amiloride therapy. the use of other medications possessing natriuretic effect as nesiritide, or arginine vasopressin antagonists. diffuse anasarca with 4+ edema and projected hypervolemia exceeding 18 kg. severe hepatic impairment (child-pugh class c). patients on hemodialysis acute myocardial infarction with symptoms of acute ischemia or changes on electrocardiogram

Keywords: canagliflozin hospitalized heart failure patients i.v loop diuretic nt-probnp
investigation of validity and reliability of the minnesota manual dexterity test in patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: many assessment tools have been developed and used to evaluate upper extremity functions in multiple sclerosis (ms) patients. while each test has its strengths and weaknesses, the most significant limitation of these tests is that only a limited number assess both hands simultaneously. on the other hand, most daily life activities require the coordinated use of both hands. in ms patients, bilateral impairments in hand functions can also be observed. therefore, there is a need for bilateral assessment tools. unlike many other assessment tools, the minnesota manual dexterity test (mmdt) allows for simultaneous evaluation of both hands. in addition to manual dexterity, it also assesses hand-eye coordination and gross motor skills. the mmdt consists of five subtests: placing, turning, displacing, single-hand turning and placing, and two-hand turning and placing. the validity of the mmdt has also been examined in ms patients. our study aims to evaluate the reliability and validity of the mmdt in ms patients. the cutoff times that best distinguish individuals with ms from healthy individuals will also be examined. the study aims to systematically and thoroughly evaluate the mmdt, establish it as a valid and reliable method for ms patients, and provide a new perspective on assessing hand functions.

at baseline, the mmdt, edss, 9-hole peg test (9-hpt), abilhand survey, and jebsen-taylor hand function test (jthft) will be applied to the ms group. the mmdt will be repeated seven days after the first application in ms. healthy controls are going to perform only the mmdt.

Eligibility criteria:
inclusion criteria: * age at least 18 years, * neurologist-diagnosed multiple sclerosis, * expanded disability status scale (edss) score between 0-6.5 * no ms exacerbation within the last 3 months, * use of stable medication in the last 3 months. exclusion criteria: * having any vision, hearing or perception problems that may affect the research results, * having an orthopedic problem that may affect manual skills in the upper extremity, * having a cardiovascular, pulmonary disorder

Keywords: minnesota manual dexterity reliability validity multiple sclerosis hand function