Kornimate/medical-research-clean huggingface dataset:
conditioned pain modulation in chronic neck pain patients

Conditions: Neck Pain

Summary: the aim of this study was to evaluate changes in local and segmental hypersensitivity and endogenous pain inhibition in people with chronic nonspecific neck pain.

quantitative sensory testing is widely used in human research to investigate the state of the peripheral and central nervous system contributions in pain processing. it is a valuable tool to help identify central sensitization and may be important in the treatment of chronic neck pain. this study is a cross-sectional study. two groups including chronic neck pain group and healthy volunteers group will be arranged in this study. the healthy subjects will be matched for sex and age in relation to the neck pain group. the pressure pain threshold (ppt) will be measured at the neck muscle in both groups. the cold pressor test will be used in both groups to activate conditioned pain modulation.

Eligibility criteria:
1. chronic neck pain subjects inclusion criteria: * age 21-80 years old. * people must have experienced neck pain for at least 3 months and have reported a minimal pain level of 30 (pain threshold) on the 0-100 pain numerical rating scale (nrs) in the last 7 days. exclusion criteria: * age under 21 or over 80. * patients were excluded if they had taken pain medications on the day of the assessment or if they had serious spinal pathologies, such as fractures, tumors or inflammatory diseases, such as ankylosing spondylitis, nerve root compromise confirmed by clinical neurological tests or severe cardiorespiratory diseases. * those who were pregnant, patients with cancer and those with a cardiac pacemaker were also excluded. 2. healthy volunteers inclusion criteria: * age 21-80 years old. * these participants must not have presented episodes of low back pain for more than 7 days in the last 12 months. exclusion criteria: * age below 21 or over 80 years old. * these participants have presented episodes of low back pain for more than 7 days in the last 12 months.

Keywords: conditioned pain modulation, neck pain
physical virtual training for older women

Conditions: Low Back Pain

Summary: the purpose of this study will be assess the effectiveness of the physical virtual training on nonspecific chronic low back pain, body balance, functional autonomy and mood of older women. two groups will be formed. one will do strength exercises and core training. the other group will do the same exercises more virtual activities with nintendo wii. will be measure pre and post-intervention of the responses already shown above.


Eligibility criteria:
inclusion criteria: * subjects with nonspecific chronic low back pain * patients without involvement in regular exercise program exclusion criteria: * patients not recommended for physical exercise (physical activity readiness questionnaire par-q) * trunk surgery * cancer * injuries in lower extremity * neurological or vestibular disease

Keywords: older virtual systems low back pain postural balance
digital health intervention for caregivers emotional and self-management support of children with type 1 diabetes

Conditions: Diabetes Mellitus, Type 1

Summary: this feasibility study builds upon mental health and technology acceptance theoretical frameworks. it seeks to examine potentials of a mobile-based novel digital health solution based on emotional and behavioral change techniques, to provide emotional and self-management tailored support to caregivers of children with type i diabetes (t1d). the digital health program, called adhera® caring, is designed to be used for approximately 3 months. the study will enroll 100 participants (20 in sub-study 1 and 80 in sub-study 2) who are caregivers of children with type 1 diabetes. there will be a nurse coaching the participants by providing support related to their emotional wellbeing via the mobile solution.

objectives: * primary objective 1. to gather qualitative and quantitative information enabling to better understand psychological burdens that caregivers of children with type 1 diabetes and perceived barriers/facilitators for adoption of a digital health solution. * primary objective 2. to assess positive mood states of caregivers of type 1 diabetes patients as an indicator of emotional wellbeing related to the use of the digital health solution. this is a prospective mixed-methods (qualitative-quantitative) exploratory study composed of two sub-studies: * qualitative sub-study 1 (ss1): one group of caregivers (n = 20) will engage with the digital health solution for 1 month. subsequently, an individual semi-structured interview with each of the participants and a usability questionnaire will proceed to gather user experience qualitative information. * quantitative sub-study 2 (ss2): a different group of caregivers (n = 80) will engage with the digital health solution for 3 months. as elaborated in the following sections, a quantitative approach will be adopted to assess different emotional and behavioral parameters before and after engaging with the digital health solution (pre-post design).

Eligibility criteria:
inclusion criteria: * caregiver of patients with type 1 diabetes under 18 years of age. * patient's debut of type 1 diabetes at least 3 months prior to the start of the study. * patients with continuous glucose monitoring. * participants with children undergoing insulin treatments (multiple dose insulin or continuous subcutaneous insulin infusion) * participants administering insulin treatment to their children * users of smartphone whose children are treated with type 1 diabetes treatment for approved indications in spain. * participants must agree on sharing data on continuous glucose monitoring data of their treated children. * participants must sign an informed consent * participants must be willing to and install the mobile solution of the study. exclusion criteria: * candidates without a smartphone or not being able to interact with it. * only one legal guardian per child can participate in the study. * participants of ss1 will not take part in ss2.

Keywords: type 1 diabetes mhealth caregiver emotional health behavioral intervention
pharmacokinetics and safety studies of esomeprazole use in schizophrenia patients

Conditions: Schizophrenia

Summary: to evaluate the pharmacokinetic and safety for the esomeprazole use for schizophrenia

investigators prepare to recruit 30 schizophrenia patients in one year. investigators will conduct a 8-week open label clinical trial for evaluation of the pharmacokinetic and safety of esomeprazole use for the schizophrenia. investigators will give 40 mg/day esomeprazole in the first two weeks and 80 mg/day from the third week to the end of the trial. investigators will check the area under the concentration of metabolites of esomeprazole on day 1, day 14 and day 56 and the genotype of cyp2c19. the gi symptoms and related drug side effects will be evaluated.

Eligibility criteria:
inclusion criteria 1. 20-65 years old 2. diagnosed as dsm-iv schizophrenia 3. no adjustment of dose of major antipsychotics for at least 4 weeks 4. competence for inform consent exclusion criteria 1. diagnosed with schizoaffective disorder or bipolar affective disorder or organic psychotic disorder 2. meet the diagnostic criteria of any substance abuse or dependence in the past 6 months 3. history or evidence of any clinically significant medical or neurological disease, such as autoimmune disease, cancer, epilepsy, etc. 4. mental retardation or pervasive developmental disorders 5. past history of allergy to esomeprazole 6. patient who is taking clozapine、 depakin or diazepam 7. pregnant 8. the patient is under the order of involuntary admission

Keywords: schizophrenia
ultrasound-guided suprascapular pulsed radiofrequency

Conditions: PAIN, INTRACTABLE, Shoulder

Summary: shoulder pain is the second most common musculoskeletal disease in adults, and it often becomes chronic due to treatment difficulties. pulsed radiofrequency (prf) therapy has become increasingly popular in the treatment of chronic shoulder pain due to its long duration of action and non-destructive method.

these patients lacked pain control despite systemic analgesics and conservative therapy and applied to our pain polyclinics for shoulder pain lasting at least 3 months. the ultrasound-guided ssprf was performed in those patients with a reduction of 50% or more vas score and those that reported healing in the arom in the diagnostic snb. the resting, motion and sleeping shoulder pain assessments of the patients were done using a visual analog scale (vas). the shoulder joint function was assessed using the shoulder pain and disability index (spadi) questionnaire and the active range of motion (arom) of the joint was measured using a goniometer in this study, investigators aimed to reveal the effects of ultrasound-guided suprascapular prf (ssprf) therapy applied to patients with chronic shoulder pain on both shoulder pain and function.

Eligibility criteria:
inclusion criteria: patients 18 years of age or older who were diagnosed with at least one of the following: adhesive capsulitis of the shoulder (m75.0), rotator cuff syndrome (m75.1), and impingement syndrome of shoulder (m75.4) according to the icd-10 classifications. these patients lacked pain control despite systemic analgesics and conservative therapy (like physiotherapy) and applied to our pain polyclinics for shoulder pain lasting at least 3 months. exclusion criteria: patients with other diseases causing chronic pain, those with neuropathic pain, those who had undergone surgery on the same shoulder, those with an allergy history from local anesthesia, those with abnormal coagulation tests, and those with cardiac pacemakers were excluded from this study.
treatment of laryngotracheal stenosis using mesenchymal stem cells

Conditions: Tracheal Stenosis; Laryngeal Stenosis

Summary: the trial evaluates the safety and efficacy of the olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis

trial evaluating the safety and efficacy of olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis with/without cartilage defects mesenchymal stem cells are obtained from tissue biopsy of olfactory mucosa using explant method. biomass of autologous mesenchymal stem cells in 10% human albumin solution is injected submucosally around and over the tissue after removal of a granuloma tissue during surgical intervention.

Eligibility criteria:
inclusion criteria: -confirmed diagnosis of chronic laryngeal or tracheal stenosis; exclusion criteria: * refuse of patient to participate in the trial; * acute infectious diseases; * chronic mental disorders with severe manifestations; * pregnancy/lactation; * intercurrent severe chronic diseases; * hiv, hepatites b/c; * active tuberculosis; * alcohol use disorder/drug addiction; * cachexia of any origin; * malignant neoplasms.

Keywords: mesenchymal stem cells tracheal/laryngeal stenosis
comparison of autogenous periosteal pedicle graft and collagen membrane in management of periodontal intrabony defects

Conditions: Chronic Periodontitis

Summary: a clinical and radiographic evaluation of autogenous periosteal pedicle graft in comparison with collagen membrane for management of periodontal intrabony defects.

twenty patients suffering from advanced chronic periodontitis were included in this randomized controlled clinical trial. each subject contributed matched pairs of two- or three-walled intrabony defects. each pair of periodontal defects were randomly assigned into the experimental group; periosteal pedicle graft guided tissue membrane or the positive control group; bioresorbable collagen guided tissue regeneration membrane. clinical and radiographic parameters were recorded at baseline and at 6 months postoperatively.

Eligibility criteria:
inclusion criteria: * severe chronic periodontitis patients with at least two sites with pocket depth ≥ 6 mm and clinical attachment level ≥ 5 mm, with radiographic evidence of bone loss 2- or 3-wall intrabony defect depth ranging from 3 to 6 mm as detected in periapical radiographs * the facial surface of teeth adjacent to the interproximal defect should be free of extensive recession and marginal bone loss, with at least a 4 to 5 mm band of keratinized gingiva to allow for periosteal manipulation exclusion criteria: * pregnant women * subjects had \<22 permanent teeth * having any given systemic disease * taking any type of medication and/or antibiotic therapy during the 3 months before the study * received periodontal treatment within the past 12 months * current or former smokers
minimal sn tumor burden

Conditions: Cutaneous Melanoma

Summary: the purpose of this registry is to collect data in order to discover whether melanoma patients with minimal sn tumor burden should undergo a complete lymph node dissection (clnd) or not. currently, if a patient has a positive (or metastatic) sn, this patient will be offered a clnd, which is a surgical intervention aiming to remove all lymph nodes from the same nodal basin as the sn. however, if the positive (or metastatic) sn is only minimally involved, some centers and/or countries do not offer a clnd routinely. as a matter of fact, the clnd procedure does not increase survival for patients with a minimal sn tumor burden, but can add prognostic information, potentially useful in the subsequent decision-making process. however, this is a surgical operation for the patient, which might be accompanied by significant side effects. moreover, only approximately 20% of patients with a metastatic sn have further lymph node metastases in the same basin, which means that about 4 patients out of 5 will not benefit from a clnd. thus, there is an urgent need to identify which sn positive patients could be safely spared from a clnd. it has been demonstrated that breast cancer patients with minimal sn tumor burden can be safely managed with nodal observation only, without performing a clnd. there is evidence that the same situation exists in melanoma as well, but this needs to be validated and this is why we are conducting this registry. the results of this registry will be crucial to establish an accepted standard of care (clnd or nodal observation) for melanoma patients with minimal sn tumor burden.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * histological evidence of primary cutaneous melanoma * metastases solely confined within the sn: * in the sub-capsular space (with no parenchymal infiltration) and with a maximum diameter of the largest metastasis not greater than 0.4 mm or * regardless of the site, any sub-micrometastasis with a maximum diameter not greater than 0.1 mm if there is more than 1 metastatic sn, the patient will be still eligible provided that all involved sn have minimal tumor burden, regardless of the amount of positive sns and the interested basin exclusion criteria: * no history of any other malignancy within the past 5 years, except for non-melanoma skin cancer (basal cell carcinomas or squamous cell carcinomas) and in situ cervical cancer * absence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial -

Keywords: minimal (sn) tumor burden stage iii patients lymphnode dissections
non-interventional study with aricept® evess

Conditions: Alzheimer's Disease; Vascular Dementia

Summary: the aricept® evess study is a prospective, non-comparative, non-interventional study on use of aricept® evess in the treatment of out-patients with ad and vascular dementia. the 24 week length of the study aims to collect data from a large number of patients (n= 400) on the safety and efficacy at the usual dosage of the product providing an overview of aricept® evess profile.


Eligibility criteria:
inclusion criteria: * outpatients (male / female), older than 50 years. * patients with clinical symptoms of mild and moderate ad and vascular dementia. * mmse score between 12 - 24. exclusion criteria: * patients with a known hypersensitivity to donepezil clorhydrat, piperidine derivatives or any of the excipients of aricept® evess. * patients with severe impaired hepatic function. * patients with pre-existing gastrointestinal ulcer disease. * patients with the history of bronchial asthma or chronic obstructive lung disease. * patients with the history of serious atrioventricular conduction disturbances.

Keywords: aricept® evess non-interventional study alzheimer's disease vascular dementia efficacy tolerability safety.
study to evaluate cardiac assessments following different treatments of smoking cessation medications in subjects with and without psychiatric disorders.

Conditions: Smoking Cessation

Summary: non-treatment extension to study a3051123, aimed at collecting data on cardiovascular safety for all participants in the a3051123 trial for an additional 28 weeks, allowing for a total of 52 weeks of cardiovascular safety data collection.

this study is an extension protocol for study a3051123. no treatment is provided during this study. this study is to monitor for cardiovascular events 28 weeks after completion of a3051123. this study is an extension protocol for study a3051123. no treatment is provided during this study. this study is to monitor for cardiovascular events 28 weeks after completion of a3051123.

Eligibility criteria:
inclusion criteria: * subjects will be eligible if they were randomized to study a3051123. exclusion criteria: * participation in study a3051123 ceased (ie, withdrew consent, lost to follow-up, etc) prior to final visit of study a3051123.

Keywords: smoking cessation psychiatric disease cardiovascular events
real world study of diagnosis and first-line treatment among patients with cancer of unknown primary in china

Conditions: Cancer of Unknown Primary Site

Summary: this study is a prospective, real world study.the objective is to observe the diagnosis and first-line treatment of chinese patients with cancer of unknown primary, and collect the clinicopathological characteristics, treatment outcomes, survival and other data of the patients.


Eligibility criteria:
inclusion criteria: * had a diagnosis of cancer of unknown primary (cup) after a standard evaluation . * prepared to receive first-line therapy for cup exclusion criteria: * patients who had previously received systemic therapy for cup * previous history of other cancers, except cervix cancer or basal cell carcinoma of the skin that has been cured * the investigator considered that there were contraindications to treatment or were not appropriate to participate in this study
prognostic factors for descending necrotizing mediastinitis development in deep space neck infections

Conditions: Infection; Mediastinitis; Neck Abscess; Inflammation

Summary: descending necrotizing mediastinitis (dnm) is the most serious complication of deep neck infections (dni) with high mortality. the objective of this retrospective study was to evaluate possible prognostic factors for dnm development in deep space neck infections.

descending necrotizing mediastinitis (dnm) is the most serious complication of deep neck infections (dni) with high mortality. the objective of this retrospective study was to evaluate possible prognostic factors for dnm development in deep space neck infections. the study enrolled patients admitted to the emergency center of vojvodina with the diagnosis of multispace dni with or without dnm either as the primary diagnosis or with discharged diagnosis after surgical treatment during 7-years period. the data were obtained from patient medical records.

Eligibility criteria:
inclusion criteria: * patients admitted to the hospital due to deep neck infection affecting two or more spaces with or without descending necrotizing medioastinitis * complete diagnosis and treatment data available from medical charts exclusion criteria: * incomplete medical data * infection confined to one deep neck space * patients treated under local anesthesia * patients with superficial skin infections * iatrogenic infections * infected tumors
a trial on the opportunity and treatment of residual deformity after reduction in developmental dislocation of the hip

Conditions: Developmental Dislocation of the Hip; Congenital Dislocation of Hip; Residual Deformity; Reduction

Summary: developmental dislocation of the hip is a common disease in children, and its incidence in china is about 9 ‰.the pathological changes of it is complex. the reluxation , subluxation and residual deformity and other complications are relatively common after treatment. the x-ray appears great acetabular index and wide medial gap , small central-edge angle. as there is no effective methods for treating such complications , investigators conducted this trial to find and prove optimal intervention time and treatment programs.


Eligibility criteria:
inclusion criteria: * the inclusion criteria consists of patients with large acetabular index ,small central-edge angle after reduction in developmental dislocation of the hip exclusion criteria: * age \>14 years * patients are complicated with mental, neurological disorders (such as hypoxic-ischemic encephalopathy, epilepsy and dementia) or significant barriers to growth. * patients are complicated with cerebral palsy, multiple joint contractures disease. * children are complicated with dysfunction of liver and kidney , blood disorders, immune deficiency disease and ecg abnormalities. * parents refused further treatment.
effects of m cimt and bilateral arm training on upper extremity chronic stroke patients

Conditions: Stroke

Summary: to compare and evaluate the effects of modified constraint induced movement therapy (mcimt) \& bilateral arm training on upper extremity in chronic stroke patients this study will be conducted

stroke is the abrupt loss of neurological function, due to disturbance of the blood flow in the brain. there is variety of crucial sign and symptoms that can occur during stroke include changes in the level of consciousness and impairments of sensation and motor or cognitive function loss. it also includes changes in perceptual and language functions. worldwide, 55 million people died of stroke in 2002, and approximately 20 percent of these deaths occurred in south asia. predicting amounts of deaths from stroke will increase to 63 million in 2015 and 78 million by 2030 with the mass occurring in the poor countries of the world. rehabilitation plays a major role in minimizing activity limitation and participation restriction or to decrease extent of impairments. stroke can cause variety of impairments which have greater impact on the patient quality of life. hemiparesis is the common impairment, in which involvement of upper limb is commonly seen. mcimt and bat techniques both play an important role in the treatment of stroke. in this research, both techniques will be use to evaluate which treatment technique is better for upper extremity chronic stroke patients. written informed consent will be taken. each participant will be requested to draw either number one or number two from a box. number one will be allocated to group a and number two will be allocated to group b. the a group will receive mcimt after applying conservative management and group b will receive bat for 5 days a week for 8 weeks.

Eligibility criteria:
inclusion criteria: * ability to follow instruction \& 2 steps command(mini mental state score \> 22) * at least 6 month after stroke exclusion criteria: * spasticity, defined as a score of 3 or more on modified as worth scale (mas) * uncontrolled hypertension (190/110 mm hg)

Keywords: bilateral arm training (bat) stroke