Kornimate/medical-research-clean huggingface dataset:
femoral fractures and covid-19.

Conditions: Covid19; Femur Fracture; Fragility Fracture

Summary: retrospective cohort study comparing the early prognosis after surgically-treated proximal femur fragility fractures in patients affected and not affected by covid-19.


Eligibility criteria:
inclusion criteria: * age ≥45 years * admitted to irccs orthopaedic institute galeazzi for proximal femur fractures from march 2020 to april 2020. * tested for covid-19 through naso-pharyngeal swab analized with rt-pcr exclusion criteria: * age \<45 years * not tested for sars-cov-2 * other fractures (including bilateral proximal femur fractures)

Keywords: proximal femur fracture fragility fracture covid-19 sars-cov2 face-covid 19 prognosis cohort study
stochastic resonance stimulation in brain plasticity and post stroke motor recovery

Conditions: Stroke, Ischemic; Healthy

Summary: this study evaluates the effectiveness of stochastic resonance electric stimulation on neuromuscular control and proprioception in healthy and individuals with stroke.

stroke is one of the leading causes of motor disability. the main intervention strategy in stroke rehabilitation is to induce cortical plasticity for motor re-learning. it has been demonstrated that electrical stimulation applied to the periphery can elicit abundant sensory afferent inputs to enhance excitability and activation area in the sensorimotor cortex. recent evidence suggested that a new type of electrical stimulation pattern, stochastic resonance stimulation, is capable of efficiently enhancing the activation of peripheral and central nervous system. therefore, the purpose of this study are to identify the effects of stochastic resonance electrical stimulation on neuromuscular control and proprioception, and to investigate the effectiveness of combining stochastic resonance electrical stimulation with rehabilitation program on post stroke motor function recovery.

Eligibility criteria:
in first stage inclusion criteria: healthy adults without history of neurological disorders or limitation in range of motion for thumb ﬂexion in the second stage inclusion criteria: 1. first-ever cerebral cortical region involved chronic stroke, onset over a month 2. able to perform active grasp on the affected side with the scores of manual muscle test at least two points 3. at stable medical condition for intervention confirmed by a specialized physician. the exclusion criteria were 1. history of other neurological disorders 2. cognitive impairment (mini-mental state examination score \< 24, mmse)29 3. unable to follow instructions 4. contraindications of es 5. under 20 years old.

Keywords: stochastic resonance proprioception motor control motor recovery
target volume mode controlled ventilator in obesity hypoventilation syndrome

Conditions: Obesity Hypoventilation Syndrome

Summary: the purpose of this study is to investigate the evolution of daytime partial pressure of carbon dioxide in the blood (paco2) after 6 weeks of noninvasive ventilation-pressure support ventilation (niv-psv) with target volume versus continuous positive airway pressure (cpap) alone versus niv-psv.

compare the efficacy between 3 ventilation modes (cpap, psv and psv with target volume) on patients with obesity hypoventilation syndrome already treated with cpap but with persistent desaturations.

Eligibility criteria:
inclusion criteria: * patients from 20 to 75 years old. * body mass index \> 32 kg/m2 * nocturnal oxygen desaturation 5 mn ≤ 88% under cpap, * paco2 \> 5,9 kpa in diurnal, spontaneous ventilation exclusion criteria: * patients with copd and vems/fvc \< 65% * patients with chf and periodic breathing (ejection fraction \<40%) * patients with a recent respiratory decompensation in the month preceding inclusion
virtual reality during pediatric cast removal

Conditions: Fractures, Bone

Summary: this study is a randomized control trial of virtual reality during cast removal procedures at a pediatric tertiary care center.

cast removal is a common outpatient procedure and is a source of pain and anxiety for children. children are often frightened by the appearance and the noise of the saw. additionally, the saw blade can become warm, and this can be uncomfortable. multiple methods have been used and studied to try to make this experience easier for children. these methods include: soft music, therapeutic play, and headphones. virtual reality (vr) devices are now increasingly affordable and portable. vr could be a way to distract children from the appearance and sound of the procedure. vr has been used in other clinical settings to help patients with the anxiety associated with medical procedures. the investigators propose a randomized trial to assess the responses (e.g. questionnaires and monitors) of children to cast removal with vr versus the standard noise reduction headphones.

Eligibility criteria:
inclusion criteria: * sustained a fracture in their arm/leg * no previous experience with a cast removal * must have at least one wrist free of immobilization (for heart rate monitor) * parents and patient are english speaking exclusion criteria: * patients with a history of epilepsy, ventricular shunt, motion sickness * patients with any history of cognitive, visual or hearing impairment

Keywords: virtual reality cast removal fracture
radiofrequency ablation for amiodarone-induced thyrotoxicosis

Conditions: Amiodarone-Induced Thyrotoxicosis

Summary: investigators intend to study the changes in thyroid hormone storage and production in amiodarone-induced thyrotoxicosis patients after rfa therapy.

investigators plan to identify patients with amiodarone-induced thyrotoxicosis (ait) that failed to respond to medical therapy or have developed side effects from medical therapy or are considered high risk for such therapy. these patients will be offered the option to undergo radiofrequency ablation (rfa) of a portion of the thyroid gland in order to decrease thyroid hormone production and/or to inactive the existing thyroid hormone store before their leakage into the circulation. investigators will follow these patients to assess their clinical response as well as their thyroid values. the safety of the procedure will also be assessed.

Eligibility criteria:
inclusion criteria: * are adults * have overt thyrotoxicosis (within 2 weeks prior to enrollment) * are receiving medical therapy for ait * are able to understand the study procedures and to comply with them for the entire length of the study * have not normalized their thyroid levels after one month of standard therapy or * have persistent and clinically significant thyrotoxicosis (less than 25% decrease in t4 value or patients requiring hospitalization with congestive heart failure (chf), tachyarrhythmias, hemodynamic instability or similar co-morbidities) after 2 weeks of standard therapy where additional medical therapy is deemed unlikely to be beneficial or with high risk of side-effects (e.g. hepatotoxicity of antithyroid medications, agranulocytosis of potassium perchlorate or atd or fluid retention associated with steroids). exclusion criteria: * pregnancy * patients with prior neck surgery or neck radiation * patients with neck anatomy that precludes easy access by rfa to the entirety of thyroid parenchyma * patients on anticoagulation therapy * patients with comorbidities deemed too high of a risk for general anesthesia * treatment with another investigational drug or intervention (within 6 weeks of planned rfa). * current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements. * inability or unwillingness of individual or legal guardian/representative to give written informed consent.

Keywords: hyperthyroidism rfa
effect of breastfeeding on lipid profile and cardiovascular risk markers in women with familial hypercholesterolemia

Conditions: Familial Hypercholesterolemia

Summary: the study aims to investigate the effects of breastfeeding on lipid profile and cardiovascular risk markers in women with familial hypercholesterolemia (fh) compared to women without fh. women with fh will be recruited in norway, the netherlands, and the czech republic. women without fh will be recruited in norway. women with and without fh who are pregnant or planning pregnancy will be recruited, and will be invited to repeated study visits from the end of pregnancy and through the first year after delivery. blood samples and data on anthropometry, health, pregnancy, lifestyle and diet will be collected. statin transfer into breast milk will also be measured in breast milk samples collected when the women end breastfeeding the child and start statin treatment.

patients with familial hypercholesterolemia (fh) have elevated plasma levels of ldl-cholesterol from first years of life. cholesterol burden through life defines risk of cardiovascular disease. in women with fh, cholesterol levels increase during pregnancy both due to physiological changes as well as discontinuation of cholesterol lowering medication during planning of pregnancy, during the pregnancy and during breastfeeding. few studies on the effects of breastfeeding on lipid profile in women with fh exists. there is also limited data on whether and to what extent the cholesterol lowering statins transfer to breast milk. the study aims to investigate the effects of breastfeeding on lipid profile and cardiovascular risk markers in women with familial hypercholesterolemia (fh) compared to women without fh. women with and without fh who are pregnant or planning pregnancy will be recruited, and will be invited to repeated study visits from the end of pregnancy and through the first year after delivery. blood samples and data on anthropometry, health, pregnancy, lifestyle and diet will be collected. statin transfer into breast milk will also be measured in breast milk samples collected when the fh women end breastfeeding the child and start statin treatment.

Eligibility criteria:
inclusion criteria for women with fh: 1. age 18 years or older, 2. confirmed diagnosis of fh through genetic testing or clinical assessment based on the dutch lipid clinic network, 3. singleton pregnancy in the third trimester, 4. a sufficient command of norwegian, dutch, czech or english language. exclusion criteria for women with fh: * not filling the inclusion criteria. inclusion criteria for women without fh: 1. age 18 years or older, 2. singleton pregnancy in the third trimester, 3. a sufficient command of norwegian or english language. exclusion criteria for women without fh: 1. known pre-pregnancy hypercholesterolemia, 2. a history of ascvd.

Keywords: breastfeeding cardiovascular disease pregnancy lipid profile women
a study to evaluate sage-217 in participants with bipolar i/ii disorder with a current major depressive episode

Conditions: Bipolar Disorder I; Bipolar Disorder II; Major Depressive Episode

Summary: this is an open-label study evaluating the safety, tolerability, pharmacokinetics, and efficacy of sage-217 in the treatment of participants with bipolar i/ii disorder with a current major depressive episode.

this study was previously posted by sage therapeutics. in november 2023, sponsorship of the trial was transferred to biogen.

Eligibility criteria:
inclusion criteria: 1. participant had a documented history of hypomanic or manic episode and a diagnosis of bipolar i or bipolar ii disorder with a current major depressive episode. exclusion criteria: 1. participant had a history of suicide attempt. 2. participant had current suicidal ideation with plans. 3. participant had a history of rapid cycling bipolar disorder.
clinical trial to evaluate the endoscopic ultrasound guided celiac plexus block for treatment of pain in chronic pancreatitis

Conditions: Pancreatitis, Chronic; Abdominal Pain

Summary: aim: to compare pain relief in patients randomly assigned to endoscopic ultrasound-guided celiac ganglia block (eus-cgb) vs standard endoscopic ultrasound-guided celiac plexus block (eus-cpb). methods: this is a single-center, double-blind, randomized parallel-group study to assess the efficacy of eus-cpb vs. eus-cgb in patients with painful chronic pancreatitis.

inclusion criteria include: age\>18 yrs, ability for informed consent, chronic daily pancreatic-type abdominal pain. exclusion criteria include: pregnancy, malignancy, recent acute pancreatitis (within 2 months), elevated inr (\>1.5) or low platelet count (\<75 cells/mm3), allergy to eggs or "caine" anesthetics.

Eligibility criteria:
inclusion criteria: * patients with chronic pancreatitis and referred for eus-guided celiac plexus block with: age\>18 yrs, ability for informed consent, chronic daily pancreatic-type abdominal pain. exclusion criteria: * pregnancy, malignancy, recent acute pancreatitis (within 2 months), elevated inr (\>1.5) or low platelet count (\<75 cells/mm3), allergy to eggs or "caine" anesthetics.
outcomes of critically ill patients with severe acute kidney injury requiring renal replacement therapy

Conditions: Critical Illness; Acute Kidney Injury

Summary: this study assess the vital status, renal function and renal recovery of patients admitted to intensive care unit and requiring renal replacement therapy for acute kidney failure. patient follow up is up to 3 years after icu admission when possible.

up to 50% of critically ill patients develop acute kidney injury and up to 10% require renal replacement therapy in the intensive care unit. this study aims to identify factors associated with mortality and to evaluate renal recovery of patients who had acute kidney failure requiring renal replacement therapy in intensive care unit at 1 and 3 years post intensive care unit admission.

Eligibility criteria:
inclusion criteria: * adults admitted to the intensive care * acute kidney failure requiring renal replacement therapy exclusion criteria: * patients suffering end stage renal failure requiring chronic renal replacement therapy * patients under 18 years

Keywords: critically ill patients acute kidney injury renal replacement therapy long term outcome
pavmed carpx device clinical study

Conditions: Carpal Tunnel Syndrome

Summary: to study the safety and feasibility of the carpx device to divide and release the transverse carpal ligament in order to provide relief for carpal tunnel syndrome (cts).

this is a prospective, single center, single arm, study of the carpx device for treatment of carpel tunnel syndrome. patients will be followed for up to 30 days post procedure.

Eligibility criteria:
inclusion criteria: * patient is \> 18 years old * patient is scheduled to undergo carpal tunnel release surgery * patient has failed to respond to conservative treatment of cts * cts confirmed by strong clinical signs and positive nerve conduction velocity (ncv) test * patient, or authorized representative, signs a written informed consent form to participate in the study, prior to any study mandated procedures patient is willing and able to complete follow-up requirements exclusion criteria: * patient has a prior or current musculoskeletal or neurologic condition that limits strength, motion, or sensation in the affected hand that is unrelated to carpal tunnel syndrome. * patient with stiff wrist, suspected space occupying lesions or other anatomic abnormalities of the forearm, wrist or hand or other concerns related to patient anatomy such as small wrist and/or thin skin * prior invasive treatment of the hand or wrist for disease processes such as de quervain's syndrome, arthritic wrist etc. on the intended treatment side * previous trauma/fracture or other anatomic abnormalities of the forearm, wrist or hand on the intended treatment side * patient has an ipsilateral injury or other conditions affecting hand function * patient has acute cts resulting from an injury (e.g., fracture) * patient has had previous ctr surgery on the affected hand * patient has severe chronic median nerve neuropathy shown by the emg and ncs that shows denervation of the thenar muscle * active local or systemic infection * known allergy to any device component * known severe allergy to contrast reagent that cannot be managed with premedication * any significant medical condition(s) that would place patient at excessive risk for surgery such as: known bleeding disorder including thrombocytopenia (platelet count \< 80,000), thrombasthenia, hemophilia or von willebrand's disease, unstable cardiac disease, renal failure or uncontrolled diabetes * patient has other medical, social or psychological problem that in the opinion of the investigator precludes them from fully participating * women who are pregnant
the effect of mother and father kangaroo care on newborn and parent outcomes in premature infants

Conditions: Kangaroo Care

Summary: first aim is to determine the effect of mother and father kangaroo care on the premature baby's comfort behavior level and physiological parameters (respiratory rate, heart rate, oxygen saturation and body temperature). second aim is to determine the effect of mother and father kangaroo care on parental satisfaction and neonatal intensive care parental stress level. the study was a a randomized crossover study with pretest-posttest design. it was carried out in the neonatal intensive care unit of selçuk university faculty of medicine hospital in konya province. study data were collected from 19 mother and 19 father and their premature newborns between february 2023 and august 2023.

in the study, the mother applied kangaroo care to her premature baby for 65 minutes, and after a 24-72 hour washout period, the father applied kangaroo care for 65 minutes. the order of mother and father application was determined randomly. data were collected using physiological parameters form, neonatal comfort behavior scale, parental satisfaction scale and neonatal intensive care unit parental stress scale. in the study, physiological parameters and neonatal comfort behavior scale scores of premature infants and neonatal intensive care unit parental stress scale and parental satisfaction scale scores of parents were evaluated. pearson chi-square test, yates correction and fisher's exact test were used to compare categorical data according to groups. two independent sample t test was used to compare normally distributed variables and mann whitney u test was used to compare non-normally distributed variables. statistical significance level was accepted as p˂0.05.

Eligibility criteria:
inclusion criteria: for premature infants; * the baby is born before 36+6 weeks of gestation stability of vital parameters at the time of application, stable health status (cardiorespiratory stability, no congenital or chromosomal abnormalities, no history of intraventricular hemorrhage, no history of periventricular leukomalacia and nec, no systemic and metabolic disorders), for parents; * willingness to participate in the research * being able to read and write turkish exclusion criteria: for premature infants; * being connected to a mechanical ventilator * congenital or chromosomal abnormality * being with deprivation syndrome * having a history of intraventricular hemorrhage for parents: * not being willing to care for kangaroos * having a physical disability to care for kangaroos

Keywords: mother kangaroo care father kangaroo care cross over study
brief intervention for ocd fears

Conditions: Obsessive-compulsive Disorder

Summary: the study will test the efficacy of propranolol or placebo, administered after reactivation of a previously acquired obsessive-compulsive disorder (ocd) fear, in reducing fear and avoidance in ocd.

twenty subjects with ocd will be enrolled in the study. participants will complete baseline assessments of fear and avoidance. participants will be randomly assigned to a single dose of propranolol 40mg or placebo, administered immediately after a fear reactivation procedure. primary outcome assessment will be ocd symptoms and avoidance behavior in a behavioral avoidance task 2 weeks after the intervention

Eligibility criteria:
inclusion criteria: * principal diagnosis of obsessive-compulsive disorder exclusion criteria: * history of other serious psychiatric disorder * current major depressive disorder * women who are pregnant or nursing * current use of psychiatric medication * persons planning to start another treatment during the study period * any significant medical condition that might increase the risk or participation or use of medications that might negatively interact with propranolol

Keywords: propanolol obsessive-compulsive disorder
bronchoscopic approach to the peripheral lung nodule - an alternative approach

Conditions: Solitary Pulmonary Nodule; Lung Cancer

Summary: patients presenting with solitary or multiple lung nodules often require tissue confirmation in order to guide further management and determine if the lesion is benign or malignant. several bronchoscopic techniques have emerged which have significantly improved the diagnostic yield of bronchoscopy in this setting, and in particular the combination of peripheral endobronchial ultrasonography (pebus) and electromagnetic navigation bronchoscopy (enb) has resulted in diagnostic yields of nearly 90%. in an attempt to reduce the significant cost of this combined approach, the sequential use of pebus followed by the more costly enb technique only if a lesion is not identified on the ultrasound image could be as accurate. this study aims to determine the diagnostic yield of this sequential approach in patients with lung nodule(s).


Eligibility criteria:
inclusion criteria: * age \>16 years * lung nodule (s) identified on ct scan * clinical decision to obtain tissue biopsy of lung lesion * ct guided biopsy not preferred technique (previous negative ct guided biopsy or technically difficult nodule location or perceived high risk of pneumothorax or other complications) * pleural based lesion only if: inaccessible by ct guided biopsy or previous ct guided biopsy non-diagnostic exclusion criteria: * lack of informed consent * nodule less than 1 cm or greater than 6 cm long axis * mediastinal adenopathy \>2cm short axis on ct chest * evidence of endobronchial abnormality on chest ct * medical contraindication to bronchoscopy * patients with lesions highly suspicious for lung cancer, potentially resectable with lobar or lesser resection and without significantly increased operative risk factors will not be entered into this study prior to surgical evaluation. * patient with implanted electronic medical device * uncontrolled or irreversible coagulopathy (platelets \ 1.3, use of clopidogrel in the 7 days prior to bronchoscopy) * confirmed or suspected pregnancy

Keywords: endobronchial ultrasound electromagnetic navigation bronchoscopy bronchoscopy ultrasonography