Kornimate/medical-research-clean huggingface dataset:
toi même: a mobile system for measuring bipolar illness

Conditions: Bipolar Disorder

Summary: bipolar disorder is a severe psychiatric illness with chronic course and it is associated with high risk of relapse and hospitalisation, and many patients do not recover to their previous psychosocial functioning. major reasons for poor outcomes are delayed intervention for prodromal mood and behavioural symptoms as well as incomplete treatment responses. current diagnostic approaches used to assess mood symptoms rely on symptom-based categories, which lack sensitivity to detect subtle mood and behavioural changes. therefore, the ability to better characterizing bipolar patients may allow to detect possible differences in the illness activity. on the other hand, there is a growing interest in the potential use of mobile technologies such as mobile apps, smartphone and internet in psychiatric care. some projects have been testing the potential benefits of mobile apps to assess and treat individuals at-risk or suffering from mood and bipolar disorders, using online signs and symptoms monitoring, yet to the investigators knowledge, none of them have integrated a dimensional approach in a smartphone app to assess mood and behavioural alterations and bipolar illness activity, including subjective and objective data (e.g. physical activity, social activity, etc.). in this feasibility study the investigators will evaluate the potential relevance of toi même app to self-monitoring mood and behavioural changes in bipolar patients with different mood phases compared to the gold-standard mood rating tools used in clinical practice. all patients will be followed for 3 months, with outcome assessments after 2 weeks, after 1 month, 2 months and after 3 months.


Eligibility criteria:
inclusion criteria: * patients with the current diagnosis of bipolar disorder type i or type ii according to the dsm-5 criteria * having an iphone with ios version from 9.x with access to wireless internet connectivity. exclusion criteria: * current dsm-5 diagnosis of schizophrenia, psychotic disorders, dementia, or mental retardation. * active suicidal ideation or behaviours.

Keywords: bipolar disorder smartphone self-monitoring objective data
68ga pet/ct imaging in breast cancer patients

Conditions: Breast Cancer

Summary: psma is highly expressed on the cell surface of the microvasculature of several solid tumors, including breast cancer. this makes it a potentially imaging target for the detection and grading of breast cancer. this pilot study was designed to evaluate the diagnostic performance of 68ga-p16-093, a novel radiopharmaceutical targeting psma, which was compared with 18f-fdg in the same group of breast cancer patients.

psma has been confirmed to be over expressed in vascular endothelial cells of various malignant solid tumors, such as breast cancer and renal cancer, which can provide growth advantages for various cancers by cutting the signal molecules involved in angiogenesis. positron emission tomography (pet) imaging using radiolabeled molecules targeting psma can detect a variety of non prostate cancer solid tumors such as breast cancer and glioma. according to previous studies, psma can detect primary and metastasis lesions of breast cancer patients, and has a higher uptake value in triple negative breast cancer and her2 overexpressed patients. the uptake may be related to tumor grade.

Eligibility criteria:
inclusion criteria: * breast cancer patients highly suggested by ultrasound or histologically confirmed; * 68ga-p16-093 pet/ct and 18f-fdg within two weeks; * signed written consent. exclusion criteria: * known allergy against psma; * any medical condition that in the opinion of the investigator may significantly interfere with study compliance.
partial breast reconstruction with chest wall perforator flap

Conditions: Breast Cancer Early Stage Breast Cancer (Stage 1-3); Breast Carcinoma; Breast Neoplasms; Breast Surgery; Breast Reconstruction Surgery

Summary: the goal of this observational study is to ascertain the outcomes following partial breast reconstruction using chest wall perforator flaps after breast conservation surgery.

the main outcomes and measures are: a) patient demographics and tumour characteristics 1. patient demographics: age, body mass index (bmi), comorbidities 2. preoperative tumour characteristics and location influencing surgical planning b) treatment characteristics 1. surgical: operative data, including flap types and distribution 2. oncological: systemic therapies (adjuvant and neoadjuvant), radiotherapy

Eligibility criteria:
inclusion criteria: * patients undergoing partial breast reconstruction using cwpf for primary breast cancer * delayed correction of breast deformity following previous bcs * each surgeon is to have performed a minimum of 10 cwpfs * each centre anticipates completing a minimum of 10/year exclusion criteria: * patients undergoing volume displacement bcs * patients undergoing mastectomy +/- immediate breast reconstruction

Keywords: breast oncoplastic, recon, chest wall perforator flap, proms
the effect of perturbration on balance control in adults

Conditions: Chronic Ankle Instability

Summary: balance control in respond to an unexpected platform perturbration during standing and walking: comparison between individuals with chronic ankle instability and healthy individuals.

an unexpected postural perturbration is a major risk factor of falls and injuries during gait. a postural perturbration is a sudden change in conditions that displaces the body posture away from equilibrium. reactive postural control response is an immediate ( 70-120 ms ) automatic "like reflex" response which is initiated by unexpected postural perturbration in order to maintain balance. even among young healthy adults there could be a problem in balance performance which does not become evident untill a slip or a trip or any other sudden perturbration happens. thus a simple test of pertubration while standing or walking can identify a problem . this study is comparing the reactive postural control of physical education students who suffer from chronic ankle instability (cai) to healthy students on a perturbation treadmill. the device consists of a treadmill mounted on a moving force plate platform. the platform moves in the medial/ lateral plains to simulate a slip and a trip in both the standing and walking phase. their reactive postural control is tested in a few conditions: standing on both legs - eyes open and eyes closed, in tandem standing, standing on one leg and in walking. in each condition the perturbration is given every 5-15 seconds in different speed and in unexpected direction (right /left). lost of balance control is any change in the original location of the foot in standing conditions or stepping out of the treadmill.

Eligibility criteria:
inclusion criteria: * age 18-50 * good health * active people exclusion criteria: * body weight greater than 135 kg * bone instability (non-consolidated fractures, unstable spinal column, severe osteoporosis) * head damage in the year prior to the study * diabetics or unstable circulation * cardiac (blood) contraindications * vestibular problem * neurological deficits * mechanical ventilation problem * severe vascular disorders of the lower limbs

Keywords: chronic ankle instability ( cai ) perturbration reactive postural control balance center of pressure - cop
intravenous indocyanine green for localization of intra-thoracic lesions

Conditions: Pulmonary Nodule, Solitary; Pulmonary Nodule, Multiple

Summary: this is a clinical trial to evaluate the intravenous administration of indocyanine green (icg) as a method of intra-thoracic lesion localization. the primary purpose is to determine if intravenous icg allows us to identify intra-thoracic lesions.

* this study is designed to determine the safety and feasibility of intra-operative localization of thoracic lesions following intravenous injection of indocyanine green (icg), determine if intravenous icg leads to the intra-operative detection of intra-thoracic lesions or metastatic lymph nodes not readily identifiable on conventional diagnostic imaging modalities, and determine if intravenous icg improves surgical resection. * at the time of surgery, the indocyanine dye will be injected intravenously. the investigators will use a dose of 0.5 mg/kg administered prior to vats. * the "filtered" near-infrared light causes the indocyanine green dye to fluoresce so that the surgeon can identify the lesions most likely to contain tumor cells.the surgeon will also look at lymph nodes to see if metastatic disease can be found in this location using this technique. the lymph nodes are processed to look for metastasis.

Eligibility criteria:
inclusion criteria: * patients with intra-thoracic lesions that require resection for therapeutic or diagnostic purposes as recommended by their thoracic surgeon. * 18 years of age or older * documented, signed, dated informed consent obtained prior to any study specific procedures being performed exclusion criteria: * subjects who do not wish to have subsequent surgical resection * a medical condition such as uncontrolled infection or cardiac disease that, in the opinion of the treating surgeon, makes resection unreasonably hazardous for the patient * pre-operative spirometry that suggests the patient is at high risk or cannot undergo resection of the primary tumor. * iodide or seafood allergy

Keywords: indocyanine green near-infrared imaging
efficacy of the consumption of a spinach extract on muscle function in subjects over 50 years of age

Conditions: Sarcopenia; Physical Exercise

Summary: controlled, randomized, single-center, double-blind clinical trial, with two parallel branches depending on the product consumed, to measure the efficacy of a supplement extracted from spinach on muscle strength in subjects over 50 years of age.

subjects who meet the selection criteria will make two visits to the laboratory to perform the tests established in the protocol. in addition, all subjects will develop a program of strength, polyarticular, individualized and progressive exercises in which the main muscle groups are worked. the program will be held three days a week (36 sessions). subsequently, a statistical analysis will be performed with the variables measured in the study to obtain results.

Eligibility criteria:
inclusion criteria: * age between 50 and 75 years. * body mass index less than 32. * subjects who do not develop physical exercise scheduled on a weekly basis. * subjects who have given written informed consent to participate in the study. exclusion criteria: * consumption during the 6 months prior to the study of functional food or supplement that modifies body composition. * presence of absolute or relative contraindications dictated by the american college of sports medicine, for the performance of physical exercise. * presence of chronic diseases that prevent the performance of a physical exercise program (disabling arthropathies, moderate / severe chronic lung disease, ischemic heart disease under treatment, arrhythmias, etc.). * abuse in the ingestion of alcohol. * present hypersensitivity or intolerance to any of the components of the products under study. * inability to understand informed consent. * serious or terminal illnesses. * subjects with a body mass index above 32. * pregnant or lactating women. * inability to understand informed consent.
core temperature in open water wetsuited swimming.

Conditions: Temperature

Summary: swimming in cold water is intrinsically unsafe. one of the threats is a fall in core body temperature (tcore), which adversely affects all body systems and increases the risk of death. wetsuits mitigate, but do not negate this threat. environmental conditions may confound findings from laboratory studies or computer models, thus necessitating open water studies. this study was designed to investigate the effects of open water wetsuited swimming on core body temperature at a range of different water temperatures between 8.4oc and 24.5oc.


Eligibility criteria:
inclusion criteria: * trained and highly trained swimmers. exclusion criteria: * a history of cardiovascular disease, arrhythmias, or gastrointestinal abnormalities precluding the use of rectal temperature measurement.

Keywords: core temperature water swim wetsuit cold
test of digital breast tomosynthesis vs. regular mammography in detecting breast cancer in women undergoing diagnostic mammography

Conditions: Breast Cancer

Summary: comparison of the ability of dbt and ffdm to detect breast cancer.


Eligibility criteria:
inclusion criteria: * women ≥18 years or older and has underwent screening mammography and is now referred for diagnostic mammography * able and willing to comply with study procedures, and have signed and dated the informed consent form * surgically sterile or postmenopausal exclusion criteria: * pregnant or trying to become pregnant * has signs or symptoms of breast cancer * has been previously included in this study * has breast implants * has a history of breast cancer and is in active treatment * has breasts too large to be adequately positioned for the dbt examination

Keywords: mammography mammogram breast abnormal and normal breast tissue
matching, outcomes and costs in substance abuse/psychiatric treatment

Conditions: Dual Diagnosis

Summary: this project�s goal is to improve the quality of care and reduce treatment costs for veterans with substance abuse and psychiatric problems.

background: this project�s goal is to improve the quality of care and reduce treatment costs for veterans with substance abuse and psychiatric problems. objectives: this project is evaluating a patient-treatment matching strategy to improve residential treatment for substance abuse patients with psychiatric disorders. its immediate objective is to examine whether the matching strategy results in more effective and cost-effective treatment in va programs. we hypothesize that patients with severe clinical problems will have better outcomes when they are matched to service-intensive programs; patients with moderate problems will have better outcomes when they are matched to programs having a lower intensity of services. for both patient groups, community treatment should prove to be more cost-effective than hospital treatment. methods: the project utilized a stratified randomized design. we paired each of three va hospital programs that treat dual diagnosis patients and are high on intensity with a nearby high-intensity community residential facility (crf) that contracts with the va. we also paired four va hospital and four crfs that are low on intensity. veterans who applied for substance abuse treatment at va facilities were randomly assigned to either the va hospital or crf. patient assessments have been conducted at intake (n=230), discharge, and a 4-month follow-up. primary outcomes are patients� severity of substance abuse and psychiatric problems. secondary outcomes are patients� functional status and their va and non-va health care utilization and its costs. status: completed.

Eligibility criteria:
inclusion criteria: patients must be entering a va inpatient substance abuse or psychiatric treatment program and be clinically judged as appropriate for inpatient or community residential care. exclusion criteria:
oral ketorolac for iud pain reduction

Conditions: IUD Insertion Pain

Summary: to determine if oral ketorolac given at different timepoints prior to intrauterine device (iud) insertion influences pain experienced during this procedure.

this is a single-site prospective interventional randomized controlled trial to examine the timing of administration of ketorolac for iud pain control. 108 patients will be recruited to the study and they will be randomized into three study arms in a 1:1:1 ratio. information including demographics, medical history, and obstetric history will be collected during enrollment. patients will arrive 3 hours prior to their iud appointment. study group "k2" will receive ketorolac 20mg per os (po) at 2 hours prior to iud insertion, then they will receive a placebo pill at 1 hour prior to iud insertion. in contrast, study group "k1" will receive the inverse: they will be given a placebo pill at 2 hours prior to iud insertion, then they will receive ketorolac 20mg po at 1 hour prior to iud insertion. study group "k0" will receive placebo pills at both timepoints. the patients will then receive a standard iud insertion by an obgyn physician. both patients and providers will be blinded to the study medications received. the standard pain control regimen for iud insertion includes offering vaginal lidocaine gel self-administered 5 minutes prior to iud insertion as well as offering lidocaine paracervical block (pcb). all patients will be offered these standard pain control methods including the "k0" group. patients may utilize one, both, or neither of these offered interventions in addition to the randomized study medication. during the iud insertion, pain scores at 7 different timepoints will be measured via a visual analog scale (vas). the vas is a 100mm visual tool that allows patients to rate the pain they are experiencing at each time interval. the 7 timepoints include: pre-procedure, tenaculum placement, block injection, uterine sounding, iud deployment, overall (measured immediately post-procedure), and 10 minutes post-procedure. information on patient acceptable symptom state (pass) and patient satisfaction will be collected during their appointment. after the 10-minute post-procedure vas score and questionnaire, patients will be discharged from the study.

Eligibility criteria:
inclusion criteria: * 18 years or older * able to consent * desires iud insertion exclusion criteria: * iud placement under sedation or oral anxiolytic * iud replacement (removal with insertion) * daily narcotic or nsaid use * contraindications to iud placement * current: pregnancy, genital/pelvic infection * lifetime history: uterine anomaly, pelvic inflammatory disease, allergy to levonorgestrel or copper * contraindications to ketorolac * current: weight under 50 kilograms * lifetime history: allergy to nsaids, liver disease, renal disease, peptic ulcer disease, cerebrovascular bleeding, gastrointestinal bleeding

Keywords: iud intrauterine device ketorolac iud pain nsaid non-steroidal anti-inflammatory drug vas pass
effects of metformin on metabolic and reproductive outcomes in chinese pcos patients

Conditions: Polycystic Ovary Syndrome; Metformin

Summary: polycystic ovary syndrome (pcos) is a reproductive endocrine disease characterized by reproductive and metabolic abnormalities, which is a crucial cause of female infertility and an essential risk factor for type 2 diabetes. at present, there exist several clinical trials and studies on the usage of metformin in the treatment of pcos patients in prediabetes, and the practical application of metformin in clinical practice has years of history. the treatment plan of metformin is of great significance in preventing type 2 diabetes in pcos patients and assisting pregnancy in pcos infertile patients.

the purpose of this study is to conduct a real world study on effects of metformin on the improvement of metabolism and reproductive outcome in chinese prediabetic pcos patients by collecting relevant medical system records from renji hospital affiliated to shanghai jiao tong university school of medicine as real world data and a significant supplement to clinical trial studies. at the same time, obese and non-obese pcos patients may have different mechanisms of insulin resistance, so this study stratified pcos patients to analyze whether metformin can improve treatment results for pcos patients with prediabetes according to different body mass index (bmi).the investigator's study is the first real world study to investigate chinese pre-diabetes pcos patients treated by metformin and the metabolic and reproductive outcomes, which is innovative. the investigator's research also has a guiding significance for the practical application of metformin in improving glucose metabolism and reproductive outcomes in patients with different body weight in clinical practice, and has great relevance for pcos patients to reduce long-term complications and improve quality of life.

Eligibility criteria:
inclusion criteria: 1. females at the age of 18-45years old; 2. diagnosed with pcos or/and impaired glucose regulation (igr)/diabetes(dm) 3. metformin regimens were used without other metabolic agents 4. the diagnosis of pcos is based on the 2003 rotterdam criteria and the diagnostic criteria for impaired glucose regulation (igr) and type 2 diabetes are based on the 2021 american diabetes association(ada) diagnosis criteria. exclusion criteria: 1. severe liver and kidney dysfunction (alt is greater than 2.5 times the upper limit of normal, or cr\>132umol/l, or egfr \<60 ml/min/1.73m2), psychosis, accompanied by severe infection, severe anemia, neutropenia disease; 2. participated in clinical trials of other drugs within 3 months; 3. in the past 5 years, there have been treated or untreated organ system tumors (except local skin basal cell carcinoma), regardless of whether there is evidence of local recurrence or metastasis; 4. a history of psychoactive substance abuse, including alcohol and a history of alcohol-related illnesses in the past 2 years; 5. any conditions judged by the investigator that affect enrollment.
sodium bicarbonate versus saline for the prevention of contrast-induced nephropathy

Conditions: Contrast-Induced Nephropathy

Summary: contrast-induced nephrophaty (cin) accounts for more than 10% of hospital-acquired renal failure. hydration with sodium bicarbonate is more protective than isotonic saline in animals. limited data are available in humans. we compared the efficacy of sodium bicarbonate versus isotonic saline to prevent cin in a large population of patients with renal dysfunction undergoing coronary angiography or intervention.


Eligibility criteria:
inclusion criteria: * patients with creatinine clearance \< 60 ml/min exclusion criteria: * contrast medium administration within the previous 10 days * end-stage renal failure requiring dialysis * refusal to give informed consent

Keywords: contrast-induced nephrophaty contrast media angiography coronary percutaneous intervention
effect of cgf on postoperative pain after third molar surgery

Conditions: Oral Complication

Summary: the purpose of this study is to evaluate the effects of concentrated growth factor (cgf) on pain after bilateral impacted third molar surgery and to determine its contribution to the healing process. the main question it aims to answer is: is cgf effective on reducing the pain in impacted third molar surgery? researchers compare the pain on the cgf-applied and cgf free sides after impacted third molar surgery. postoperative pain is assessed using the visual analogue scale. tthe postoperative outcomes including pain are clinically assessed at different-time intervals (1-7 days).


Eligibility criteria:
inclusion criteria: * patients with bilateral, symmetrical, bone-retained (vertical, mesioangular, horizontal) impacted wisdom teeth in the mandible, regardless of gender * patients without any systemic disease * patients who have been informed about the duration, purpose and requirements of the study and who have signed the informed consent form voluntarily. exclusion criteria: * having a disease affecting general health that requires the application of prophylactic antimicrobial agents * having a systemic viral, fungal or bacterial infection * patients with acute or chronic maxillary sinusitis * suspected or diagnosed pregnancy and nursing mothers * patients with heart and vascular diseases * patients with liver disease, haematological disease and neoplastic disease * patients who have recently received anti-inflammatory therapy * patients with chronic medication use (antihistamines, nsaids, steroids and antidepressants) * patients predisposed to psychotic or psychopathic tendencies * patients with rheumatic diseases, blood diseases, diabetes mellitus * patients at cardiological risk of infective endocarditis * patients under antibiotic pressure

Keywords: pain third molar vas scale