Kornimate/medical-research-clean huggingface dataset:
real-world study (rws) of lanreotide autogel (lan) for the treatment of patients with acromegaly in china

Conditions: Acromegaly

Summary: this study aims to assess the one-year effectiveness and safety of lan among patients with acromegaly in china in routine clinical practice. in addition, the study is designed to understand the real-world treatment patterns and outcomes of lan among chinese patients with acromegaly.


Eligibility criteria:
inclusion criteria: * participants who are able to comply with the protocol * participants with serum igf-1 level above the uln for age and sex, and serum fasting gh level above 2.5 μg/l * participants with acromegaly who are naïve to lan treatment and about to initiate lan exclusion criteria: * participants who are currently participating in any investigational study or clinical trial of acromegaly * pregnant participants * participants with hypersensitivity to somatostatin or related peptides or to any of the excipients
itopride in functional dyspepsia:a dose finding study

Conditions: Functional Dyspepsia

Summary: this study aims to determine the efficacy and optimal dose of the prokinetic itopride for the treatment of patients with functional dyspepsia. the study will test in patients with functional dyspepsia the hypothesis that itopride is superior to placebo with regard to the improvement of symptoms.

treatment of patients with functional dyspepsia remains unsatisfactory. we will assess the efficacy of itopride, a d2 antagonist with acetylcholinesterase effects in patients with functional dyspepsia. patients with functional dyspepsia will be randomized to itopride (50, 100 or 200 mg tid) or placebo. after 8 weeks of treatment, three primary efficacy endpoints will be analyzed: a) change of the severity of functional dyspepsia symptoms (assessed by the leeds dyspepsia questionnaire), b) patient's global assessment of efficacy (proportion of patients symptom-free or markedly improved)and c) improvement of pain and/or fullness by at least one grade on a 5-grade scale.

Eligibility criteria:
inclusion criteria: diagnosis of functional dyspepsia (rome criteria) - exclusion criteria: structural or biochemical abnormalities explaining the symptoms, concomitant symptoms of gastroesophageal reflux disease or irritable bowel syndrome dominating the clinical picture -

Keywords: functional dyspepsia non ulcer dyspepsia drug treatment
lovenox with aspirin in thawed blastocyst transfer

Conditions: Infertility, Female

Summary: this prospective randomized trial will compare outcomes in patients receiving aspirin in combination with a low-molecular weight heparin and those under this center's standard protocol receiving neither medication, in order to determine if these medications may improve success rates.

this prospective randomized trial will compare outcomes in patients receiving aspirin (81mg daily) in combination with a low-molecular weight heparin (lmwh) (enoxaparin (lovenox®), 40mg daily subcutaneous injection) and those under this center's standard protocol receiving neither medication, in order to determine if these medications may improve success rates.

Eligibility criteria:
inclusion criteria: 1. female patient 18-42 years of age with frozen embryos or oocytes seeking embryo transfer. 2. use of pre-implantation genetically tested (pgt) blastocysts is allowed but not required. 3. use of donated embryos or embryos derived from donated eggs is allowed. 4. prior history of successful, failed, and/or canceled ivf cycles are allowed. exclusion criteria: 1. minor (age\<18 years). 2. currently pregnant. 3. unable to provide informed consent in english. 4. gestational carrier or "surrogate". 5. blastocysts frozen at another center (oocytes frozen elsewhere is acceptable). 6. subject intending or having "natural cycle" thaw transfer with an active ovarian follicle present. 7. currently participating in any other research study. 8. subject already had an embryo transfer under this study. 9. history of thrombocytopenia (reduced platelets), bleeding disorders, or routinely using anti-coagulant medication. 10. hypersensitivity to aspirin, heparin, or benzyl alcohol. 11. anyone for whom the physician assesses this protocol is inappropriate or unsafe.
comparison of epithelial lining fluid and blood pharmacokinetics and pharmacodynamics of intravenous and intravenous plus nebulized polymyxin b in multidrug resistant bacteria ventilator-associated pneumonia patients

Conditions: Polymyxin B; Ventilator-associated Pneumonia; Multidrug Resistant Bacterial Infection; Pharmacogenomic Drug Interaction

Summary: the goal of this observational study is to investigate whether intravenous polymyxin b combined with nebulisation achieves better antimicrobial efficacy and clinical outcomes than intravenous use alone in patients with multidrug-resistant gram-negative bacilli infected with ventilator-associated pneumonia. the main questions it aims to answer are: * when using intravenous polymyxin b to treat patients with ventilator-associated pneumonia caused by multidrug-resistant bacteria in clinical practice, is it necessary to assist with polymyxin b nebulization therapy？ * if necessary, how much dose of nebulization is better? participants will be divided into two groups based on whether they have received nebulization treatment with polymyxin b in clinical practice. blood and alveolar lavage fluid samples will be collected after the first dose injection and reaching the steady-state dose, and the drug concentration differences in blood and elf will be measured in patients who have received intravenous injection of polymyxin b alone and those who have received adjuvant nebulization of polymyxin b, as well as differences in clinical outcomes and side effects. researchers will compare the differences in blood and elf drug concentrations, clinical outcomes, and incidence of side effects between two groups of patients, to see if is it necessary to assist with polymyxin b nebulization therapy in patients with multidrug-resistant gram-negative bacilli infected with ventilator-associated pneumonia.


Eligibility criteria:
inclusion criteria: * 18-80 years old; * icu patients; * patients with mdr-infected vap were diagnosed by etiological culture results; * expect to receive at least 6 doses (3 days) of polymyxin b; * obtain informed consent; exclusion criteria: * the patient has a history of severe hypersensitivity to polymyxin b; * patients cannot tolerate alveolar lavage; * oncology patients,includes hematologic malignancies; * pregnant or lactating women; * patients with other conditions that the investigators consider unsuitable for enrollment;
nmda-enhancing agent for the treatment of mild cognitive impairment

Conditions: Mild Cognitive Impairment

Summary: nmda neurotransmission plays an important role in learning and memory. nmda receptors were found to decrease in the frontal lobe and hippocampus of mild cognitive impairment. this study is a randomized, double-blind, placebo-controlled drug trial. all subjects will be allocated randomly to 2 groups: (1) nmda-enhancer: daoib group (starting dose: 250-500 mg/d); (2) placebo group. the study period is 24 weeks. the investigators hypothesize that daoib may yield better efficacy than placebo for cognitive function in patients with mild cognitive impairment.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of mild cognitive impairment * mmse between 17-26 * cdr 0.5 exclusion criteria: * hachinski ischemic score \> 4 * substance abuse/dependence * parkinson disease, epilepsy, dementia with psychotic features * major depressive disorder * major physical illnesses * severe visual or hearing impairment
evaluation of the clinical performance of the zikv detect™ 2.0 igm capture elisa

Conditions: Zika Virus Infection

Summary: the purpose of this study is to evaluate the performance of the zikv detect™ 2.0 igm capture elisa using archived confirmed zikv positive and confirmed zikv negative human serum samples.

the purpose of this study is to evaluate the performance of the zikv detect™ 2.0 igm capture elisa using archived confirmed zikv positive and confirmed zikv negative human serum samples. the fda guidance document (zika serology de novo/510(k) pre-market submissions - recommended analytical and clinical studies for zika virus igm assays; dated 02jun2017; fda/cdrh/oir/dmd) allows for the utilization of archival serum specimens to evaluate test performance. this study will follow this guidance. test samples will be collected from endemic sites (both presumed positive and presumed negative samples) and from non-endemic sites (presumed negative samples). all samples will be shipped to the sponsor for randomization and will be tested at three sites in the united states.

Eligibility criteria:
inclusion criteria: * human males and females of varying ages and geographical locations where zika virus is endemic and not endemic. * retrospective (archived) and prospective human serum samples. archived samples will fall under the category of "leftover" specimens as described by fda guidance. exclusion criteria: • samples that are not de-identified.
assessment of coronary endothelial function in diabetic patients with acute coronary syndrome using 15o-water positron emission tomography

Conditions: Myocardial Infarction

Summary: type 2 diabetes is associated with early and diffuse abnormalities of endothelial function, especially in the coronary arteries, which are a factor of poor prognosis. following acute coronary syndrome, the endothelial function abnormalities usually persist for several weeks before regressing. their persistence 6-8 weeks after myocardial infarction is a poor prognostic factor. investigators assume that global abnormalities of endothelial function in patients with diabetes may be additive with segmental abnormalities in revascularized myocardium, and contribute to worsening the prognosis in these patients. furthermore, there is no published data showing any relationship between calcium score and endothelial function abnormalities in these patients. the investigators seek a relationship between calcium score and persistence of abnormalities of coronary endothelial function in these patients. the main objective of this study was to compare coronary endothelial function by quantitative method (tep at 15o-h2o) in diabetic patients and nondiabetic following acute coronary syndrome.


Eligibility criteria:
inclusion criteria: * patients with a first myocardial infarction, type 2 diabetic or non-diabetic treated by angioplasty in acute phase (timi 3) * myocardial viability test before discharge * age over 18 years * informed consent dated and signed by the patient * written and spoken french * beneficiary of social security insurance exclusion criteria: * hypertension\> 160/90 mmhg despite medical treatment * lack of effective revascularization in acute phase of myocardial infarction (timi grade \<3) * significant three-vessel coronary artery disease (\> 70% stenosis in the other two coronary arteries); occlusion of a coronary artery; schedule revascularization (percutaneous or surgical); left main coronary artery stenosis * previous history of myocardial infarction * mechanical complication (mitral regurgitation, ventricular septal rupture, left ventricular free wall rupture) * heart failure * no myocardial viability test before discharge, for whatever reason * type 1 diabetes * pregnant and / or lactating * age under 18 years or guardianship
improvement of physical and physiological parameters through the use of a mobile app

Conditions: Hypertension; Diet, Healthy; Body Weight; Obesity; Cholesterol; Lipidosis; Machine Learning

Summary: to investigate the health effects of a new mobile application (app) for prevention and personalized treatment in people with chronic cardiovascular pathologies associated with body composition.

scientific evidence has shown that the adoption of the mediterranean diet is a protective factor against the appearance of several types of cancer, cardiovascular diseases, aging and obesity due to the amount of nutrients with anti-cancer, anti-inflammatory and anti-obesity properties that jointly contribute to the maintenance of health status. the antitumor effects of the mediterranean diet are mainly due to the combination of antioxidant elements, fiber and polyunsaturated fats. therefore, this dietary pattern is essential as a preventive measure against the onset of cancer and other chronic diseases, but also to reduce health care costs. monitoring physical activity should be considered as a central factor when addressing precision nutrition. perform physical activity and exercise, as they are key components of energy expenditure and balance, in addition, structural changes occur in muscles, increase in the number of mitochondria in fiber, secretion of metabolically beneficial hormones with reversal of muscle insulin resistance and reduction of hepatic lipogenesis. regardless of intensity, short-term exercise has been shown to improve adiposity and insulin sensitivity, which may help reduce metabolic risk. boutcher et al. also demonstrated that intermittent aerobic and anaerobic exercise performed at an intensity \>70% of maximal oxygen uptake significantly reduces ambulatory and office blood pressure in hypertensive individuals. the development of this app aims, through self-management and visualizing the altered parameters and how they will evolve in your body in the short, medium and long term, to increase the population's commitment to these pathologies, in order to improve their health.

Eligibility criteria:
inclusion criteria: * men and women over 21 years of age exclusion criteria: * volunteers who do not have access to a smartphone.
exercise versus cognitive behavioural therapy on cancer-related fatigue

Conditions: Fatigue; Mood; Maximal Oxygen Uptake

Summary: the investigators compare the effects of two interventions, an endurance exercise program and a cognitive behavioural therapy, on the fatigue, quality of life, mood and physical performance of patients with a cancer-related fatigue syndrome. the intervention will be carried out for 4 weeks. tests will be carried out at the beginning and at the end of the study.


Eligibility criteria:
inclusion criteria: * age 18-70 * histologically confirmed neoplastic disease * treatment (chemotherapy or radiation) completed. * no treatment in the previous 4 weeks * ability to understand written german exclusion criteria: * health conditions which can be aggravated by exercise
assessment of ergonomics in 3d vs 2d thoracoscopic lobectomy

Conditions: Early Stage Non-small-cell Lung Cancer (Stage 1-2)

Summary: video-assisted thoracic surgery (vats) pulmonary lobectomy is currently widely employed as the first treatment option for surgical management of early stage (stage i-ii) non-small-cell-lung-cancer (nsclc). thanks to recent technological advances in high definition display systems, three dimensional vats (3d) has been developed in an attempt of overcoming some optical limits of two dimensional (2d) vats. in this single center randomized trial our aim is to comparatively assess ergonomics of 3d versus 2d vats lobectomy for early stage nsclc.

video-assisted thoracic surgery (vats) is widely employed for pulmonary lobectomy in early stage non-small-cell-lung-cancer (nsclc). indeed, vats is thought to represent an optimal minimally invasive surgical option which is deemed superior to conventional thoracotomy since it enables smaller incisions with no rib spreading thus minimizing both postoperative pain and hospital stay. for over than three decades, several thoracic surgeons adopted vats for anatomical lung resection using two-dimensional (2d) display systems. however, a 2d image lacks depth of perception which may negatively affect surgical manoeuvring. three dimensional (3d) display systems for vats can offer superior magnified vision of the surgical field and better perception of depth during surgical manoeuvring potentially shortening learning curve, which may thus overcome some optical limitations of 2d systems. in this single center randomized trial our aim is to comparatively assess ergonomics of 3d versus 2d vats lobectomy for early stage (stage i-ii) nsclc. for this purpose we compared three ergonomical domains: exposure, instrumentation and maneuvering with the aid of a scoring scale entailing analysis of 5 main technical steps: vein, artery bronchus, lymph node and fissure score. the evaluation process of the five surgical steps was carried out by 4 thoracic surgeons who individually scored all recorded operations.

Eligibility criteria:
inclusion criteria: * clinical nsclc early stage (stage i-ii). * both forced expiratory volume in one second (fev1) and diffusion capacity of carbon monoxide (dlco)\>60% * both predicted postoperative (ppo) fev1 and ppo dlco \>35% * american society of anesthesia (asa) score\<=2 * body mass index (bmi) \>18 \<28 exclusion criteria: * clinical nsclc stage\> ii * history of neoadjuvant chemotherapy or radiotherapy * radiologic evidence of extensive pleural adhesions. * age \ 80 years. * patients with previous pleurodesis or thoracotomy in the affected hemithorax. * patients who will undergo surgical lung resection other than lobectomy. * patients with severe comorbidity contraindicating lobectomy. * patients refusal or noncompliance to general surgery and one-lung ventilation.

Keywords: vats lobectomy 3d vats vats ergonomics non small cell lung cancer three-dimensional thoracoscopy
epidural and cardiac surgery

Conditions: Cardiac Disease

Summary: in the present study the investigators test the hypothesis that the epidural anesthesia added on the general anesthesia is able to improve patient's outcome.


Eligibility criteria:
inclusion criteria: * patients undergoing cardiac surgery * adult (\>18y) * sternotomy exclusion criteria: * abnormal coagulation profile * antiplatelet medications (other than aspirin) * ongoing anticoagulation

Keywords: cardiac surgery cardiac anesthesia epidural
exercise and nutrition on obese microbiome

Conditions: Overweight and Obesity

Summary: the purpose of this study is to examine the effects nine weeks of intense exercise training will have on weight, inflammation, and intestinal bacteria composition of overweight and obese adults.


Eligibility criteria:
inclusion criteria: 1. individuals who are overweight (bmi ≥ 25) and/or obese (bmi ≥ 30). 2. individuals who volunteer for the 54-day exercise program. 3. individuals with no history of diabetes mellitus (type i or ii) or sickle cell disease. 4. individuals who are not taking antibiotics and have not taken antibiotics within 3 months. 5. individuals who are not taking probiotics. 6. individuals who are not taking metformin. 7. individuals who are cleared by their physician to perform strenuous exercise. 8. individuals with no physically debilitating injuries that would keep them from being able to perform the exercises prescribed. 9. individuals who are between 18 and 60. exclusion criteria: 1. any subjects who do not meet all of the inclusion criteria and/or are unable to consent.
predicting factors for asthma remission in children

Conditions: Asthma

Summary: the purpose of this study is to determine the predicting factors for asthma remission in children.

children who were diagnosed as having asthma during the period of 2004-2007 and reevaluated in 2015.

Eligibility criteria:
inclusion criteria: * children who were diagnosed as having asthma during the period of 2004-2007. exclusion criteria: * patients who had underlying disease with chronic respiratory disease (ex. tuberculosis, bronchiectasis), primary immunodeficiency, other seriously interfering diseases * medical records have been lost.

Keywords: asthma remission predicting factors children
epidural study of patients with chronic lower back pain

Conditions: Chronic Low Back Pain

Summary: the purpose of this study is to examine 4 different epidural dosing regimes of local anaesthetic solution in a series of 3 epidural injections over a period of 12 months to determine the optimum dose of anaesthetic solution for pain relief and to determine the nature of any adverse events by measuring anxiety and depression, functionality and any side effects of the medication.

to determine the optimum dose of local anesthetic and the optimum volume of injected solution when used in an epidural steroid injection being given for pain relief to patients with chronic lower back pain, using pain scores as an assessment tool.

Eligibility criteria:
inclusion criteria: * 18-75 years old * lower back pains \> 6 months * no lumbar epidural in past 6 months * no previous back surgery * written informed consent to participate in study exclusion criteria: * acute lower back pain * pregnancy * significant psychiatric disease * local or systemic infection * coagulopathy/anticoagulant therapy * bleeding diathesis * presently enrolled in another study

Keywords: epidural volume dose pain relief steroid
transperineal versus transrectal prostate biopsy

Conditions: Prostate Cancer

Summary: background: prostate biopsies are essential to diagnose prostate cancer (pca). transrectal prostate biopsies (tr-pb) are commonly performed, however disadvantages include the requirement of antibiotic prophylaxis (ap) and higher complication rates than transperineal prostate biopsies (tp-pb). guidelines still recommend the use of ap for tp-pb due to the limited evidence regarding complication rates after their omission. however, the rising rates of antibiotic resistance is of concern. the aim of this study was to compare the complication and detection rates of freehand tp-pb without ap versus tr-pb with ap. methods: this single center retrospective study was performed in an academic hospital. tp-pb were introduced in 2019 and implemented as the main technique by late 2020. to compare the two techniques, data was collected for freehand tr-pb with ap between 2017-2018 and freehand tp-pb without ap between 2021-2022. the data from 2019 and 2020 were excluded to rule out the effects of the initial learning curve during the transition period. primary outcome measure was post-biopsy complications occurring within 2 weeks, focusing on infectious complications. secondary outcome measures were detection rates and upgrading/reclassification in the repeat biopsy in active surveillance (as). statistical analysis was performed using a fisher exact or chi-squared test.


Eligibility criteria:
inclusion criteria: * men who underwent prostate biopsy between 2017-2018 (transrectal) * men who underwent prostate biopsy between 2012-2022 (transperineal) exclusion criteria: * positive urine culture before biopsy * patients in the transrectal biopsy group who did not take the prescribed course of antibiotic prophylaxis * incomplete medical dossier where the occurrence of a complication could not be assessed

Keywords: prostate biopsy prostate cancer transperineal transrectal