Kornimate/medical-research-clean huggingface dataset:
safety related factors of endotracheal intubation in patients with severe covid-19 pneumonia

Conditions: COVID-19; Endotracheal Intubation

Summary: to analyze the intubation with severe covid-19 pneumonia, the infection rate of anesthesiologist after intubation, and summarizes the experience of how to avoid the infection of anesthesiologist and ensure the safety of patients with severe covid-19 pneumonia.

to analyze the intubation time, intubation condition, intubation process, intubation times and success rate of patients with severe covid-19 pneumonia, the infection rate of anesthesiologist after intubation, the degree of respiratory improvement and survival rate of patients, and summarizes the experience of how to avoid the infection of anesthesiologist and ensure the safety of patients with severe covid-19 pneumonia.

Eligibility criteria:
inclusion criteria: * wuhan residents; * novel coronavirus pneumonia was found to be characterized by fever and cough. laboratory tests revealed leukocyte or lymphocyte decrease, chest ct examination showed viral pneumonia changes, and was diagnosed as covid-19 pneumonia according to the national health and health committee's new coronavirus pneumonia diagnosis and treatment plan (trial version fifth revision). * severe and critical patients with covid-19 pneumonia in urgent need of tracheal intubation; * sign informed consent. exclusion criteria: * suspected patients with covid-19 pneumonia; * patients who need emergency endotracheal intubation due to other causes of respiratory failure; * the family refused to sign the informed consent.
prenatal ultrasound screening of intestinal malrotation with a higher risk of volvulus

Conditions: Intestinal Malrotation

Summary: the aim of this study was to assess the value of an unusual relative position of the superior mesenteric artery (sma) and vein (smv) to screen intestinal malrotation with a higher risk of volvulus. first, feasibility study was done to prove the reproducibility of ultrasound in diagnosis of anormal mesenteric vessels position. a systematic screening of the mesenteric vessels position was performed at each pregnancy required ultrasound. when the fœtus had an unusual position of the mesenteric vessels, an mri was suggested between 30 and 35 ga and the couple met the pediatric surgery team. few days after birth, an abdominal ultrasound was achieved as well as a barium enema and upper gastrointestinal. if there were a hight probability of malrotation with a higher risk of volvulus, a prophylactic surgery was proposed. the children were flollowed up during 1 year.


Eligibility criteria:
inclusion criteria: * pregnant women * second or third trimester ultrasound. exclusion criteria: * fœtal ultrasound anomaly

Keywords: superior mesenteric artery superior mesenteric vein intestinal malrotation volvulus pregnant women mesenteric vessels position postnatal diagnosis prophylactic surgery
fluoroscopically-guided epidural block in the midthoracic region: a comparison of anterioposterior versus oblique view approach

Conditions: Low Back Pain Requiring Epidural Injection

Summary: a comparison of anterioposterior versus oblique view approach method for fluoroscopically-guided epidural block in the midthoracic region. the investigators evaluate differences on total radiation time and technical feasibility between anterioposterior and oblique view approach method.


Eligibility criteria:
inclusion criteria: * adult patients who were scheduled for the transforaminal epidural injection in midthoracic region (t5-t7) exclusion criteria: * local anesthetic allergy, coagulopathy
role of herbal immunomodulators in the treatment of chronic periodontitis

Conditions: Chronic Periodontitis

Summary: addition of systemic herbal immunomodulators with scaling \& root planing (srp) may enhance the therapeutic result of chronic periodontitis owing to host modulation \& anti-inflammatory properties. if proven, herbal immunomodulators can be used as an adjunct to srp.


Eligibility criteria:
inclusion criteria: 1. patients within age group of 30 to 55 years. 2. systemically healthy individuals. 3. patients with chronic generalized periodontitis (moderate and severe) according to center of disease control (cdc) working group, 2007 criteria exclusion criteria: 1. patients with systemic illnesses (i.e., diabetes mellitus, cancer, human immunodeficiency syndrome, bone metabolic diseases, or disorders that compromise wound healing, radiation, or immunosuppressive therapy), 2. smoking, 3. chronic alcoholics, 4. pregnancy or lactation, 5. use of non-steroidal anti-inflammatory drugs (nsaids), steroids or antibiotics / antimicrobials within january 2012 to jun 2013, 6. confirmed or suspected intolerance to herbal medicines, 7. periodontal therapy done within the january 2012 to jun 2013.

Keywords: herbal medicine, host modulation therapy, periodontitis, meta-analysis, scaling and root planing.
early detection and characterization of primary ciliary dyskinesia

Conditions: Primary Ciliary Dyskinesia

Summary: primary ciliary dyskinesia (pcd) is a severe genetic disorder caused by various mutations in genes affecting ciliary motility. various new and complementary diagnostic techniques, including measurements of nasal nitric oxide (no), video microscopy (vm), immunoflourescence (if) and genetic analysis have recently been recognized as simpler and more accurate modalities for the diagnosis and characterization of patients with pcd compared to electron microscopy. while considered a rare disease worldwide, pcd is more prevalent among highly consanguineous populations, such as those found in israel. we hypothesize that using modern state of the art and novel test modalities on a national scale in israel will improve diagnosis, improve phenotypic-genotypic correlations and create a national registry for pcd.

primary ciliary dyskinesia (pcd) is a severe genetic disorder caused by various mutations in genes affecting ciliary motility. while diagnosis of pcd in israel is currently based for the most part on electron microscopy (em) detection of ciliary ultrastructural defects, this technique may be unsatisfactory and does not overcome the inherent heterogeneity. thus, late and under-diagnosis and suboptimal characterization of patients is common. various newer and complementary diagnostic techniques, including measurements of nasal nitric oxide (no), video microscopy (vm), immunoflourescence (if) and genetic analysis have recently been recognized as simpler and more accurate modalities for the diagnosis and characterization of patients with pcd. while considered a rare disease worldwide, pcd is more prevalent among highly consanguineous populations, such as those found in israel. given the rarity of cases particularly familial ones, the most useful implementation of new diagnostic techniques requires multicenter collaboration. we hypothesize that using modern state of the art and novel test modalities on a national scale in israel will improve diagnosis, improve phenotypic-genotypic correlations and create a national registry for pcd. we propose to perform such a multicenter study whose aims are: * to characterize the complex phenotype and genotype of pcd in israel, using state-of-the-art and novel diagnostic techniques. * to create a national registry of patients and families with pcd in israel * to develop robust national standards of diagnosis and evaluation, which will lead to better and earlier diagnosis, treatment and counseling.

Eligibility criteria:
inclusion criteria: * patients with pcd diagnosis * subjects with suspected diagnosis of pcd exclusion criteria: * subjects uncooperative with study procedures

Keywords: cilia phenotyping diagnosis nitric oxide bronchiectasis
study to provide continued access to treatment for patients completing a previous trial with efanesoctocog alfa

Conditions: Severe Haemophilia A

Summary: this is a multinational, prospective, open-label, roll-over study in patients with severe haemophilia a, ≥6 years of age, who have completed participation in any of the parental studies with efanesoctocog alfa; xtend-ed study (lts16294), freedom study (sobi.bivv001-001), or pk comparison study (sobi.bivv001-003). the aim of the study is to provide patients with continuous benefit from efanesoctocog alfa treatment and to further continue clinical monitoring for safety and efficacy until efanesoctocog alfa is commercially available in each patient's respective country (or until march 2027, whichever comes first). the study starts with the baseline visit, which will be done in connection to the end of study visit (or equivalent) in the respective parent study. subsequent study visits (on site or phone call) will be done approximately every 13 weeks until end of treatment. an end of study safety phone call will be done 14 (+7) days after the end of treatment visit.


Eligibility criteria:
inclusion criteria: * capable of giving signed informed consent. parents or legally designated representatives' consent is required for patients who are below 18 years of age or unable to give consent. patients who are below 18 years of age may provide assent in addition to the parents'/legally designated representatives' consent, if appropriate. * must have completed one of the required parent studies: sobi.bivv001-001, sobi.bivv001-003, or lts16294, and be receiving a clinical benefit from the efanesoctocog alfa treatment, as judged by the investigator. * willingness and ability of patient or their parent or legally designated representative to complete training in the use of the study patient diary and to complete the diary throughout the study. exclusion criteria: * positive inhibitor result (assessed by central laboratory), defined as ≥0.6 bethesda units (bu)/ml, at baseline visit. * ongoing or planned participation in any interventional clinical study at baseline visit. * patient not suitable for participation, whatever the reason, as judged by the investigator, including medical or clinical conditions, or patients potentially at risk of noncompliance to study procedures.

Keywords: haemophilia a blood coagulation disorder factor viii fviii coagulation protein disorder severe haemophilia a efanesoctocog alfa
combining donepezil with perceptual learning in normal and amblyopic human the effect of donepezil on perceptual learning in adult amblyopia

Conditions: Amblyopia

Summary: the research deals with amblyopia or lazy eye, a condition that affects about 3% of the population, and results in a variety of visual deficits. recent work suggests that there is limited neural plasticity in the visual system of adults with amblyopia. this study is aimed at understanding and increasing this plasticity. in this study, the investigators aim to understand how the amblyopic brain learns and how this process is affected by a drug called donepezil, which is sometimes given as a treatment for alzheimer's disease. the investigators hope that this study will help to identify the chemical components that help the brain to learn, as well as the mechanism of amblyopia. the investigators also plan to test the normal periphery, as control.

the research deals with amblyopia or lazy eye, a condition that affects about 3% of the population, and results in a variety of visual deficits. recent work suggests that there is limited neural plasticity in the visual system of adults with amblyopia. this study is aimed at understanding and increasing this plasticity. in this study, the investigators aim to understand how the amblyopic brain learns and how this process is affected by a drug called donepezil, which is sometimes given as a treatment for alzheimer's disease. the investigators hope that this study will help to identify the chemical components that help the brain to learn, as well as the mechanism of amblyopia. the investigators also plan to test the normal periphery, as control. in this study, donepezil will be administered while amblyopic subjects (or normally sighted subjects tested in the periphery) are trained on a low-contrast single-letter recognition task, or an uncrowd task (recognizing a letter closely embedded within two other letters). subjects will be asked to identify the target letter (the low-contrast single letter, or the letter embedded within other letters). training will take place for 10 consecutive days. pre- and post-tests will be conducted immediately before and after training, and will consist of the measurements of visual acuity, crowding extent and contrast threshold for recognizing single letters.

Eligibility criteria:
subjects with amblyopia inclusion criteria: * corrected visual acuity being 20/30 or worse in the poorer eye (at least 20/20 in the better eye) * reduced stereoacuity * normal retina exclusion criteria: * with other diagnosed eye diseases subjects with normal vision inclusion criteria: * corrected visual acuity at least 20/20 in each eye * normal stereoacuity * normal retina exclusion criteria: * with other diagnosed eye diseases

Keywords: amblyopia donepezil perceptual learning crowding contrast sensitivity visual acuity
safety and efficacy of bi 10773 as add-on to insulin regimen in patients with type 2 diabetes mellitus

Conditions: Diabetes Mellitus, Type 2; Obesity

Summary: this trial will evaluate use of bi 10773 as add-on to insulin regimen alone or with metformin in patients with typr 2 diabetes. both lowering glucose and hba1c and reducing the use of insulin in this population would provide significant new information for the bi 10773 use and would offer a potential new therapeutic option in this population.


Eligibility criteria:
inclusion criteria: 1. diagnosis of t2dm prior to informed consent 2. male and female patients on diet and exercise regimen who are pre-treated with multiple daily injections (mdi) of insulin alone or in combination with immediate or extended release metformin 3. stable metformin therapy: daily dose \>=1500 mg/day or maximum tolerated dose 4. hba1c \>=7.5% and \<=10% at screening exclusion criteria: 1. uncontrolled hyperglycemia with a glucose level \>240 mg/dl (\>13.3 mmol/l) after an overnight fast during placebo run-in 2. any contraindications to metformin according to the local label 3. acute coronary syndrome, stroke or tia within 3 months prior to informed consent
retina implant pilot trial to evaluate safety & efficacy in blind patients having degenerated photo-receptors

Conditions: Retinitis Pigmentosa

Summary: the outcome of this trial will reveal the possibilities of the retinal implant to improve the situation of patients with hereditary retinal blindness caused by degenerations of the outer retina. this pilot study will give important information on safety and efficacy of sub-retinal implants.

although the design of the chip with a possible resolution of up to 1500 image points has the potential of providing object recognition, the quality of the image transmitted in this first human application cannot be foreseen. on the other hand clinical experience teaches us that even bare light recognition improves mobility of patients because of the ability to localize bright light sources such as windows or lamps.

Eligibility criteria:
inclusion criteria: * hereditary retinal degeneration of the outer retinal layers with the retinal vessels still being perfused and pigments of mild to moderate density * blindness (at least monocular) or visual functions not appropriate for navigation/orientation * period of appropriate visual functions \> 12 years / lifetime * visual acuity ≥ 0,05 in earlier life * electrically evoked phosphenes provide evidence of inner-retinal function. * willing and able to give written informed consent exclusion criteria: * any other ophthalmologic disease with relevant effect upon visual function (e.g. glaucoma, optic neuropathy, trauma, diabetic retinopathy, retinal detachment) * systemic disease that might imply considerable risk with regard to the surgical intervention and anesthesia (e.g. cardiovascular diseases, severe metabolic diseases) * neurological and/or psychiatric diseases (e.g. m. parkinson, epilepsy, depression ) * retina detected as too thin (\< 100 µm) to expect required rest-functionality as shown via optical coherence tomography (oct). * women who are pregnant or nursing, or women of childbearing potential who are not willing to use a medically acceptable means of birth control for the duration of the study, or women unwilling to perform a pregnancy test before entering the study * participation in another clinical trial within the past 30 days

Keywords: legal blindness retinopathy pigmentosa hereditary condition photo-receptor degeneration retina implant subretinal implant
acute effect of exercise on vascular function

Conditions: Aging

Summary: the study objectives are the following: 1) to examine the acute vascular responses to continuous low- and moderate-intensity exercise and interval training; and 2) to examine the influence of age and gender on these responses.

the type, intensity and duration of exercise, fitness state, and timing of measurements have been reported to influence the acute vascular responses to exercise. however, little is known regarding the influence of interval training, aging and gender on these responses. the objectives of this study are: 1) to examine the acute vascular responses to continuous low- and moderate-intensity exercise and interval training; and 2) to examine the influence of age and gender on these responses. subjects will perform the following 3 types of treadmill exercise in a random order: 1) slow-pace walking; 2) moderate-pace walking; and 3) interval training. flow mediated dilation using high resolution ultrasonography and arterial stiffness using applanation tonometry will be measured before, immediately after and 1-hour after each acute bout of exercise.

Eligibility criteria:
inclusion criteria: * men and women 18 to 79 years of age * women will be premenopausal or postmenopausal (either natural or surgical) defined as a cessation of menses for at least 2 years. * premenopausal women will be eumenorrheic. * able to give consent. exclusion criteria: * history of hepatic disease or infection with hepatitis b, c or hiv * history of other relevant on-going or recurrent illness * recent (within 3 months) or recurrent hospitalizations * current intake of medications that may affect study results * use of tobacco products * premenopausal women taking oral contraceptives and postmenopausal women taking hormone replacement therapy. * pregnancy (positive urine pregnancy test) or lactation * perimenopausal women
severity of sarcopenia in parkinson's disease

Conditions: Parkinson Disease

Summary: the aim of the study is to examine the severity of sarcopenia in parkinson's disease patients. patients between the ages of 40-75 who have been diagnosed with parkinson's disease by a neurologist and healthy individuals with similar demographic characteristics will be included in the study as a control group. the staging of parkinson's patients will be done with the modified hoehn and yahr scale, and the severity of the disease will be done with the unified parkinson's disease rating scale. within the scope of the study, anterior thigh thicknesses of individuals with parkinson's disease will be evaluated with ultrasonography. sarcopenia severity will be determined with the isarcoprm algorithm using the ultrasonographic evaluations of the individuals. it is planned to include 80 parkinson's patients in the study. parkinson's patients between stages 1-3 according to the modified hoehn and yahr scale will be included in the study.


Eligibility criteria:
inclusion criteria: * score between 24 and 30 on the mini mental state examination * be diagnosed with parkinson's disease by a neurologist * stage 1-3 on the modified hoehn and yahr scale exclusion criteria: * inability to communicate verbally * elderly people with severe visual impairment, neurological disorders in addition to parkinson's and/or congestive heart failure * older adults in whom exercise is not recommended

Keywords: sarcopenia ultrasonography
walnuts and glucose variability

Conditions: Type-2 Diabetes

Summary: persons with type 2 diabetes mellitus (t2dm) have swings in their blood sugar levels that may lead to a higher risk of developing heart disease. an important part of diabetes management involves eating a diet to prevent large swings in blood sugar levels. walnuts contain fat, protein and fiber that may reduce the swings in blood sugar. the purpose of this study is to compare the effects of a walnut-free american diabetes association (ada) diet versus 2 levels of walnut-enriched ada diets on blood sugar swings. eighteen male and female adults with t2dm will participate in the study. subjects will be randomized to consume an ada diet with or without walnuts for 3 consecutive days every other week. subjects must test their blood sugar twice daily and wear a continuous glucose monitor during the three 72-hour study periods. subjects will be between 40 and 70 years of age and will be recruited from the surrounding community using flyers and public service announcements. consent will take place in the department of nutrition at loma linda university by the study investigators. in total, subject participation will last 5 weeks and all meals will be provided during the 3 study periods.


Eligibility criteria:
inclusion criteria: * adults between age 40 and 70 years with type 2 diabetes * duration of type 2 diabetes more than 6 months but less than 10 years * hba1c 6.0-8.0% * bmi 25-40 kg/m2 * diet controlled or stable dose of metformin for at least 3 months * willing to test blood glucose with personal meter twice a day during study test days exclusion criteria: * using oral hypoglycemic agents or insulin * history of ischemic heart disease or congestive heart failure * history of severe diabetic complication (neuropathy, renal failure, stroke) * taking medication affecting glucose levels (i.e. corticosteroids) * active infectious disease * active malignancy * pregnant or breast feeding woman * smoker * history of daily caffeine or alcohol intake * known allergy to nuts * lactose or gluten intolerance

Keywords: glucose variability glycemia type-2 diabetes