Kornimate/medical-research-clean huggingface dataset:
vaniprevir plus pegintron®/ribavirin in japanese participants with chronic hepatitis c who are non-responders to previous treatment (mk-7009-045)

Conditions: Hepatitis C, Chronic

Summary: the purpose of this study is to evaluate the safety, tolerability, and efficacy of vaniprevir (300 mg twice daily) given in combination with pegylated interferon alfa-2b (peg-ifn) and ribavirin (rbv) in japanese participants with chronic hepatitis c (chc) genotype (gt) 1 who have not responded to previous treatment. the primary efficacy objective is to estimate efficacy of vaniprevir, peg-ifn and rbv for 24 weeks as assessed by the percentage of participants achieving undetectable hepatitis c virus ribonucleic acid (hcv rna) 24 weeks after completion of all study therapy (sustained viral response 24 \[svr24\]).


Eligibility criteria:
inclusion criteria: * japanese participant diagnosed with compensated chc gt 1 * absence of ascites, bleeding esophageal varices, hepatic encephalopathy, or other signs or symptoms of advanced liver disease * has received and tolerated treatment with ifn-based therapy (ifn α, ifn β, or peg-ifn) with or without use of ribavirin, but failed to respond to the prior treatment (partial responder or null responder) * no evidence of cirrhosis exclusion criteria: * co-infection with human immunodeficiency virus (hiv) * positive hepatitis b surface antigen or other evidence of active hepatitis b infection * any other condition that is contraindicated or for which caution is required for treatment with peg-ifn or rbv * any condition or pre-study laboratory abnormality, or history of any illness, that, in the opinion of the investigator, might confound the results of the study or pose additional risk in administering the study drugs, peg-ifn and rbv, to the participant
comorbidities of epilepsy(cognitive and psychiatric dysfunction)

Conditions: Epilepsy

Summary: epilepsy is the second commonest chronic neurological disorder in developed countries ,comorbidity refers to the co-occurrence of two conditions with greater frequency than found in the general population


Eligibility criteria:
inclusion criteria: patients with primary epilepsy. aged above 18 years old. exclusion criteria: * patient diagnosed as secondary epilepsy or epilepsy syndromes
a randomized trial of external beam radiotherapy versus cryoablation in patients with localized prostate cancer

Conditions: Prostate Cancer

Summary: a trial to determine if cryoablation is as effective as radiation in the treatment of men with localized prostate cancer.

men with newly diagnosed localized prostate cancer were randomly assigned to cryoablation or external beam radiotherapy (median dose 68 gy). all patients received neoadjuvant antiandrogen therapy. the primary endpoint was disease progression at 36 months based on a trifecta definition of failure: (a) radiological evidence of metastatic disease or b) initiation of further antineoplastic therapy or c) biochemical failure). two definitions of biochemical failure were used: 1) rising psa with a final value \>1.0 ng/ml and 2) rise above psa nadir + 2 ng/ml. secondary endpoints were overall survival, disease-specific survival, and positive prostate biopsy at 36 months.

Eligibility criteria:
inclusion criteria: * clinically localized prostate cancer * psa \< 20ng/ml * negative bone scan exclusion criteria: * previous turp * previous hormone therapy

Keywords: cryoablation radiation prostate cancer
efficacy of clevudine plus lamivudine for lamivudine-resistant chronic hepatitis b patients

Conditions: Chronic Hepatitis B

Summary: the purpose of this study is to determine the optimal antiviral treatment for lamivudine resistant hepatitis b patients.

lamivudine with adefovir combination therapy has been known as effective antiviral therapy for lamivudine resistant chronic hepatitis b patients. it is superior to adefovir monotherapy since the incidence of viral breakthrough of combination therapy used to be less than that of adefovir monotherapy in lamivudine resistant chronic hepatitis b patients. clevudine, which is being marketed in korea, is a nucleoside analogue of the unnatural beta-l configuration that has potent activity against hbv. it has demonstrated potent antiviral efficacy and significant biochemical improvement after 24 weeks of therapy. we hypothesized that clevudine plus adefovir combination therapy for lamivudine resistant patients might be as effective as the lamivudine plus adefovir combination therapy. in detail, we designed to perform this clinical study comparing the combination of clevudine and adefovir with lamivudine plus adefovir in lamivudine resistant chronic hepatitis b patient. total treatment duration of both groups will be 12 months, and compare the efficacy of antiviral effects of these drugs.

Eligibility criteria:
inclusion criteria: * hbsag positive and anti-hbs negative more than 6 months * ymdd mutation (+)during lamivudine therapy * serum alt more than two times upper normal value exclusion criteria: * hav igm ab + and/or hcv ab+ and/or hdv ab and/or hiv av+ * the sign of decompensated liver disease * pregnant or lactating woman * the history of hemoglobinopathy, autoimmune hepatitis, alcoholic liver disease * hemoglobin less than 8 g/dl (male), 7.5g/dl (female) or neutrophil count less than 1500/mm3 or platelet count less than 50,000/mm3 * serum creatinine more than 1.5 times upper normal limit value * the sign of malignancy or suggestive of malignancy or the history of malignancy, the recurrence rate within 2 years of which is more than 20%

Keywords: chronic hepatitis b lamivudine resistance clevudine
socioeconomic inequalities exacerbated by mitigation measures to covid-19 and differences in prematurity prevalence

Conditions: COVID-19 Pandemic; Preterm; Low Birth-weight

Summary: objective: to assess the perinatal results in uruguay during the semester of successful control of the covid 19 pandemic to evaluate the impact of the crises in the public and private sub sectors of the health system. methodology: an analytical observational study was carried out, comparing the semesters from march 15 to september 30, 2019 (year prior to the covid 19 pandemic) with the same period 2020 (year of the covid 19 pandemic), in the 2 sub sectors of public and private health care.

an analytical observational study was carried out, comparing the semesters from march 15 to september 30, 2019 with the same period 2020, in the 2 sub sectors of public health care of the private sub sector throughout the country, taking all births in that period of time. the semester selected is based on the fact that the first months of the pandemic were the ones with the greatest mitigation measures with drastic socio-economic consequences, but it was also a period of almost zero covid infection in pregnancy, this being an opportune moment not to have as confounding factor to the maternal and fetal biological complications of this infection. the situation will be analyzed in the 2 sub sectors of public health care, made up of the state health services administration (asse), police health and military health, and the udelar clinic hospital, on the one hand, and the private sub-sector. made up of the institutions of collectivized medical assistance (iamc) of montevideo and the interior (fepremi) and the private health care insurance. the primary variable to be analyzed in both periods and in both subsectors of the national integrated system health was the incidence of preterm births (less than 37 weeks gestational age), low birth weight (newborns with a birth weight less than 2,500 grams) and intrauterine growth restriction (marked by doctor attending the birth, as a clinical diagnosis of the current pregnancy) for the analysis of the national data, of the study periods, the database was requested from the ministry of public health. this database is provided to researchers anonymously

Eligibility criteria:
inclusion criteria: * all live birth exclusion criteria: * stillbirth

Keywords: covid-19 preterm low birth weight
adrenaline injections to children born at elective cs

Conditions: Respiratory Distress; Hypoglycemia

Summary: children born after elective c-section have a greater risk of respiratory problems and hypoglycemia - most likely due to a lower concentration of stress hormones compared to children born vaginally. hypothesis: can we eliminate or reduce the risk of respiratory distress and hypoglycaemia by administrating adrenaline to the newborn.


Eligibility criteria:
inclusion criteria: * all children born at elective section with gestational age more than 37 + 0 exclusion criteria: * children in whom a serious malformation was found during pregnancy assuming this malformation will lead to very early death or respiratory problems. * serious malformations (ex.anencephalia) will be excluded at birth * other malformations will be estimated by investigator whether it will lead to exclusion.
effects of music therapy on huntington's disease

Conditions: Huntington's Disease

Summary: the purpose of this study is primarily to assess the ability of a music therapy program to improve holistically the psychological, somatic, and social symptoms of patients with huntington 's disease (hd). we hope to demonstrate the benefits of applying music therapy interventions to the management methods of hd, thus paving the way for the development of an effective music therapy program for individuals with hd.

abstract background: recent studies show that music therapy helps improve the symptomatic manifestations of parkinson's disease. few studies have looked at music therapy as a treatment for the psychiatric, cognitive and motor symptoms of patients with huntington's disease (hd). objective: to examine the feasibility and tolerability of a treatment program of music therapy for patients with huntington's disease. also, to determine if music therapy improves the mood and motor features of hd while improving quality of life. methods: subjects with hd were recruited to participate in a six-week study that included one individual, half-hour music therapy session and one hour-long group session per week. the music therapy protocols were adapted from the colorado state university's neurological music therapy program and were targeted to hd symptoms including balance and posture, fine motor skills, memory and attention, vocalizations, and mood. in particular the protocols included rhythmic auditory stimulation (ras), pattern sensory enhancement (pse), and therapeutic instrumental music playing (timp). primary outcome of tolerability was to be assessed by the subjects' adherence to the therapeutic protocol, attendance, and the results of an exit survey inquiring about their feelings toward the use of music therapy in hd. a secondary outcome of the study was the change in the unified huntington's disease rating scale (uhdrs) score between baseline and study completion. results: five subjects were recruited for study participation (one female and four males). music therapy was found to be a tolerable and feasible treatment for patients with hd (100% adherence and 98% attendance). exit surveys demonstrated strongly positive feelings towards the music therapy treatment program in four of the five subjects (one survey was completed with contradictory answers by the subject). while there was improvement in uhdrs scores for finger tapping, pronation/supination and the luria, these changes did not achieve statistical significance with the small sample size in this study. conclusions: music therapy was well tolerated among subjects with hd in this small study. future studies are now being planned to look at the efficacy of this intervention in a larger population of hd subjects.

Eligibility criteria:
inclusion criteria: * diagnosis of hd * over the age of 18 * patients must be ambulatory, use of a walker or human support is acceptable * patients must be able to communicate their thoughts and feelings exclusion criteria: * anyone without the preceding characteristics

Keywords: huntington's disease, music therapy, quality of life
what are you looking for? psychometric and experimental analyses of reassurance seeking in obsessive-compulsive disorder

Conditions: Obsessive-Compulsive Disorder

Summary: this study evaluates the efficacy and acceptability of two cognitive-behavioural interventions for reassurance seeking behaviour in obsessive-compulsive disorder (ocd), a family accommodation reduction protocol vs. a novel support-seeking protocol. half of participants will be randomly assigned to participate in the support-seeking intervention, whereas the other half will participate in the family accommodation reduction intervention.

an existing family accommodation reduction intervention to reduce reassurance seeking behaviour in ocd (which represents treatment as usual, or tau) is being compared to a novel support-seeking intervention to determine which is more efficacious and acceptable to participants. the tau protocol asks participants to make an agreement with their significant others to withhold reassurance when it is sought. it is believed that this behaviourally-based intervention encourages extinction of reassurance seeking over time by eliminating reinforcement of the behaviour by significant others. the support-seeking intervention asks participants to move towards adaptively seeking support from a significant other to manage anxiety or distress rather than seeking reassurance. significant others are taught to provide support rather than reassurance. it is believed that support-seeking may reduce reassurance seeking behaviour because it helps participants manage the anxiety or distress that underlies the requests for reassurance without interfering with disconfirmatory learning.

Eligibility criteria:
inclusion criteria: * diagnosis of ocd * engaging in reassurance seeking more than once a day about the same thing * willingness to allow the experimenter to contact a significant other from whom the participant seeks reassurance regularly * ability to read, write, and communicate in english exclusion criteria: * current suicidal ideation/intent * current substance abuse * psychosis * diagnosis of bipolar disorder (i or ii) * if participants are on medication they must be on a stable dose (i.e., have maintained a consistent dose for at least three months) and agree not to change their medication regimen for the duration of the study
evaluation of viral shedding patterns and clinical outcomes of influenza patients

Conditions: Influenza

Summary: the objective of the study is virological assessment (e.g., proportion of prolonged viral shedding, median days to viral clearance, and viral load) in laboratory-confirmed adult influenza patients admitted to the general ward and/or to the icu and to assess the correlation with the clinical manifestations and prognosis.


Eligibility criteria:
inclusion criteria: * written informed consent * hospitalized or admitted to icu for influenza * age ≥18 years * laboratory confirmation of influenza a or b exclusion criteria: * informed consent not given

Keywords: influenza virus viral shedding epidemiology
folinic acid in autism

Conditions: Autism Spectrum Disorder

Summary: an examination of changes in urinary metabolites with use of folinic acid in children with autism spectrum disorder (asd). investigators will also measure behavioral measures and academic measures monthly at school with teachers and parents report.

children enrolled in oak hill school will enroll in this study and take folinic acid supplement twice a day for 12 weeks period. behavioral measures and urinary metabolites will be collected pre and post treatment. behavioral measures will be taken again at 16 weeks, after 4 weeks of not dosing.

Eligibility criteria:
inclusion criteria: * between ages 5 and 25 exclusion criteria: * not currently taking folinic acid
preventing depression relapse with mindfulness-based cognitive therapy

Conditions: Depression

Summary: this study will determine the effectiveness of mindfulness-based cognitive therapy (mbct) in preventing depression relapse.

depression is a serious condition that can cause significant social and emotional problems and reduce the overall quality of life. relapses in depressive episodes are common and may result in a patient's reluctance to follow a treatment regimen, thus making the episode more severe. safe and effective therapies to prevent depression relapse are needed. this study will compare three different approaches to determine which is most effective in preventing relapses in depressive episodes. this study will comprise 2 parts. in part 1, all participants will receive antidepressant medication for 6 months. participants whose depression symptoms do not improve will complete their study participation at the end of part 1. participants who respond to their regimen will be enrolled in part 2. this part will last 18 months. during part 2, participants will be randomly assigned to one of three groups. participants in group 1 will continue the drug regimen they began in part 1. participants in group 2 will discontinue their antidepressants and attend an 8-week relapse prevention program. this mbct program is designed to help participants learn skills that can increase their awareness and change their reaction to stressful events. participants in group 3 will have their antidepressant medication from phase 1 switched to a placebo without their knowledge. self-report scales will be used to assess the depressive symptoms of participants at the beginning of the study, at the end of phase 1, and at the end of the study, after phase 2.

Eligibility criteria:
inclusion criteria: * meet dsm criteria for recurrent major depressive disorder, defined as at least one major depressive episode within 3 years prior to study entry and at least 2 months of normal functioning following the episode exclusion criteria: * depression secondary to a concurrent medical disorder * current use of medication that could cause depressive symptoms * a rating of level 2 or higher on the index of treatment refractory depression * current diagnosis of any of the following psychiatric disorders: psychotic or organic mental, bipolar, primary obsessive compulsive, borderline personality, antisocial personality, or eating * current diagnosis of comorbid chronic depression that is disabling * current substance abuse * score less than 14 on the hamilton rating scale for depression-17 (hrsd-17) * at risk for suicide * pregnancy or plan to become pregnant during the study * practice meditation more than once a week or yoga more than twice a week at study entry

Keywords: depression recurrence drug therapy cognitive therapy relapse antidepressants
longitudinal study of neurogenetic disorders

Conditions: Neurodevelopmental Disorders; Intellectual Disability; Developmental Delay; Autism Spectrum Disorder; Seizures; Hypertonia, Muscle; Hypotonia

Summary: the purpose of this study is to analyze patterns in individuals with hnrnp (and other) genetic variants, including their neurological comorbidities, other medical problems and any treatment. the investigators will maintain an ongoing database of medical data that is otherwise being collected for routine medical care. the investigators will also collect data prospectively in the form of questionnaires, neuropsychological assessments, motor assessments, and electroencephalography to examine the landscape of deleterious variants in these genes.

neurodevelopmental disorders are a group of disorders in which the development of the central nervous system is disturbed. the genetic basis for many neurodevelopmental disorders has continued to expand and a recent gene called hnrnph2 (heterogeneous nuclear ribonucleoprotein h2, encoded by hnrnph2) is one such gene that is associated with a common neurodevelopmental disorder characterized by developmental delay, intellectual disability, autism and autistic features, and tone abnormalities, among other multisystem problems. the investigators will expand the genetic cohort to include any individual with a confirmed variant in any gene presenting with neurodevelopmental abnormalities. this is non-interventional study that examines both data previously used in clinical practice and prospective data collection in the form of questionnaires and assessments. the investigators will examine patterns of initial presentation, patterns in neurological evaluations; neurological testing including brain mri and electroencephalography, and outcomes in individuals with genetic variants. genes of focus: hnrnpa1 hnrnpa2 hnrnpb1 hnrnpb2 hnrnpc2 hnrnpd hnrnpe1 hnrnpe2 hnrnpe3 hnrnpe4 hnrnpg hnrnph1 hnrnp h2 hnrnpi hnrnpk hnrnpl hnrnpm hnrnpp hnrnpq1 hnrnpq2 hnrnpq3 hnrnpr hnrnpu

Eligibility criteria:
inclusion criteria: * individuals must have had whole genome/exome sequencing and have a confirmed variant in any gene. exclusion criteria: * subjects who cannot provide genetic confirmation of a predicted deleterious variant in any gene.

Keywords: gene variant hnrnpa1 hnrnpa2 hnrnpb1 hnrnpc1 hnrnpc2 hnrnpd hnrnpe1 hnrnpe2 hnrnpe3 hnrnpe4 hnrnpg hnrnph1 hnrnph2 hnrnpi hnrnpk hnrnpl hnrnpm hnrnpp hnrnpq1 hnrnpq2 hnrnpq3 hnrnpr hnrnpu
effect of resistant starch type 4 on glycemia and insulin sensitivity in young adults

Conditions: Hyperglycemia

Summary: this study tested the effects of resistant starch type 4 on blood sugar and hunger in young adults with type 2 diabetes.

to measure the blood glucose response, after an overnight fast, blood samples were collected before eating and at 15, 30, 45, 60, 90, and 120 minutes after each each bar. the incremental area under the curve was used to calculate the glycemic index and insulin sensitivity via minimal model.

Eligibility criteria:
inclusion criteria: * apparently healthy (not diagnosed with disease) * young adults (18-35) exclusion criteria: * diagnosed with diabetes or other metabolic disorders * allergies to wheat * non-smokers

Keywords: diabetes diet fiber age
efficacy and safety of biphasic insulin aspart 30 for the treatment of type 2 diabetes mellitus

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this study is conducted in asia. the aim of this observational study is to collect efficacy and safety data of biphasic insulin aspart (novomix® 30) in type 2 diabetes under normal clinical practice conditions.


Eligibility criteria:
inclusion criteria: * subjects from hospitals or clinics, diagnosed with type 2 diabetes mellitus
a study of angiotensin-ii receptor blocker on cardiovascular remodeling (value trial)

Conditions: Coarctation of Aorta; High Blood Pressure

Summary: the purpose of this study is to evaluate the effectiveness and mechanism of action of losartan in the treatment of coarctation of aorta.


Eligibility criteria:
inclusion criteria: * b/s1 hypertension * sbp 100-139 average based on 3 office measurements. * age 18 or older * previous coa repair exclusion criteria: * currently on beta blocker (bb) therapy * pregnancy/lactating * egfr\<30 * hyperkalemia (serum potassium \>5.5mmol/l) * severe aortic or mitral valve stenosis or regurgitation * epicardial cad diagnosis * received antihypertensive medications within the past year