Kornimate/medical-research-clean huggingface dataset:
multi-mode stroke rehabilitation system: development and validation of clinical efficacy

Conditions: Stroke; Cerebrovascular Disorders; Central Nervous System Diseases

Summary: the specific study aims will be: 1. to develop the novel, digital, and interactive msr system of arm and hand with integrated digital action observation therapy (aot) and mirror therapy (mt). 2. to pilot usability testing for examining the feasibility of this new msr system from the users' experiences and feedback. 3. to examine the treatment effects of digital aot, digital mt and a control intervention in patients with stroke by conducting a randomized controlled trial. 4. to identify who will be the possible good responders to digital aot and mt based on their baseline motor function and mental imagery abilities.

phase i: multi-mode stroke rehabilitation (msr) system development \& usability testing ten patients with stroke and 4 certified occupational therapists were recruited in this phase i study. during the pilot testing, each stroke patient will try to use each training mode of digital aot and mt by the assistance of the therapist. at the end of the pilot testing, the patients and the therapists will be asked to complete the system usability scale and a self-designed questionnaire to assess the user experience and perspective about this new msr system and their view of its suitability for stroke patients. phase ii: validation of clinical treatment efficacy this three-arm, single-blind, randomized controlled trial will investigate the treatment effects among the 3 groups of digital aot, digital mt, and dose-matched control intervention. an estimated 60 patients with stroke will be recruited to participate in this phase ii study. each participant will receive a total of 15 training sessions (60 minutes per session) for 3 to 4 weeks. clinical outcome measures will be conducted at baseline, immediately after treatment (the fourth week), and at 1 month follow-up after treatment.

Eligibility criteria:
phase i: multi-mode stroke rehabilitation (msr) system development and usability testing for stroke patients inclusion criteria: * diagnosed as having a unilateral stroke; * aged from 20 to 80 years; * a baseline score of the fugl-meyer assessment in a range of 20 to 60; * able to follow the instructions and able to provide user feedback verbally; * without aphasia and neglect for therapists inclusion criteria: * holding an occupational therapist license phase ii: validation of clinical treatment efficacy inclusion criteria: * diagnosed as having a unilateral stroke; * at least 6 months after stroke onset; * aged from 20 to 80 years; * a baseline score of fma in a range of 20 to 60; * able to follow the study instructions; * capable of participating in therapy and assessment sessions exclusion criteria: * global or receptive aphasia, * severe neglect, * major medical problems or comorbidities that have influenced upper-limb usage or caused severe pain

Keywords: stroke multi-mode rehabilitation action observation mirror therapy digital image technology
hypertension in primary health care: lifestyle change and blood pressure goals

Conditions: Blood Pressure; Life Style

Summary: the purpose of this study is to determine whether a program that includes 1) group seminars and 2) follow-up visits with blood pressure measurement and motivational interviewing (mi) that is focused on lifestyle change affect blood pressure.

high blood pressure is common in the population. in an earlier study conducted in our local geographical area, "how is health in jordbro?" 46% of participants had a systolic blood pressure of \>140 millimeters of mercury (mm hg) and 22% had a diastolic blood pressure \>90 mm hg. 84% of those with known hypertension had a systolic blood pressure of \>140. we thus found that many people in our area have heightened blood pressure, and hypothesized that many of these people, particularly those with mild hypertension, probably could be helped with lifestyle-related intervention. all persons who came to jordbro primary health care center during a 6-month period were invited to participate in the current study, and local press announcements were used to recruit additional participants. a total of 301 persons volunteered to participate. a total of 141 of the volunteers had a systolic blood pressure =\>140 and/or a diastolic blood pressure of =\>90, and these people became the study population. the 141 persons in the study population filled in a questionnaire with general background and lifestyle questions. of the 141 persons in the study population, 75 had previously known hypertension and 66 had hypertension that was previously unknown. participants were then randomized such that an equal number of persons with previously known and previously unknown hypertension were included in a) a treatment group and b) a control group. background information such as height, weight, pulse, smoking habits, other diseases, and prescription drugs was gathered. blood sugar and lipid tests were conducted. participants' family physician were contacted as necessary (e.g., if blood pressure was dangerously high). the intervention consisted of 2 group seminars with information on hypertension and related lifestyle factors and 2 follow-up visits with each participant in which blood pressure was measured and motivational interviewing took place. the motivational interviewing focused on lifestyle factors, including physical activity, stress, tobacco use, alcohol habits, and diet. after 6 months, a follow-up was done that included blood pressure measurement and completion of the same questionnaire that was filled in at baseline.

Eligibility criteria:
inclusion criteria: * =\> 30 years * ability to speak swedish well enough to fill the baseline and follow-up questionnaires, participate in the seminars, and participate in the motivational interviewing exclusion criteria: * \< 30 years * inability to speak swedish well enough to fill the baseline and follow-up questionnaires, participate in the seminars, and participate in the motivational interviewing

Keywords: blood pressure life style body mass index obesity, abdominal blood chemical analysis
pilot study: relaxation and guided imagery in hispanic persons diagnosed with fibromyalgia

Conditions: Fibromyalgia; Pain; Functional Status; Self-Efficacy; Distress

Summary: the purpose of this pilot study was to test the effects of a 10-week relaxation and guided imagery intervention on pain perception, functional status, self-efficacy and levels of distress in hispanic adults diagnosed with fibromyalgia.

fibromyalgia (fm), a chronic widespread pain condition with an unknown pathogenesis and no known cure, affects 2 to 4 million persons in the adult us population. one of the most common conditions seen in rheumatology clinics world wide, including the us, mexico, and spain, fm is accompanied by various co-occurring symptoms such as fatigue, disturbed sleep, stiffness and depression. while studies of fibromyalgia in hispanics have been reported in spain, brazil and argentina, very few such studies have been reported in the united states. this gap exists despite data indicating that there are a reported 16 million hispanics with rheumatic diseases in the us and that hispanics (self-identified) form the fastest growing minority group in this country.

Eligibility criteria:
inclusion criteria: * ages 18 and older * diagnosis of fibromyalgia based on the american college of rheumatology criteria and documented by the patient's primary physician * a minimum of a 6th grade education level * an ability to understand and sign the consent form and understand and complete the intervention (pencil and paper) assignments. exclusion criteria: * presence of other systemic rheumatologic conditions such as rheumatoid arthritis, lupus, and/or sjogren's disease * adequate functional status as indicated by a fibromyalgia impact questionnaire score \< 20 * inadequate cognitive status as evidenced by a mini-mental state exam score \< 25 * history of epilepsy * major communicative disorder.

Keywords: fibromyalgia relaxation imagery pain functional status self efficacy minority health
evaluating a shared decision making program for crohn's disease

Conditions: Crohn's Disease

Summary: specific aim: study the impact of the crohn's disease shared decision making program on patients' treatment choice, persistence with chosen therapy, decision quality, cost of care, and outcomes hypothesis: the crohn's disease shared decision making program will help patients understand which treatments are right for them and will lead to a higher acceptance of appropriate therapy, improved persistence with chosen therapy, lower costs and improved clinical outcomes. to accomplish this aim, investigators will perform a randomized controlled trial to: 1. determine how the shared decision making program influences patients' choice of therapy 2. evaluate how the shared decision making program affects persistence with chosen therapy 3. determine how the shared decision making program affects decision quality 4. determine how the shared decision making program influences cost of care and clinical outcomes expected outcome and impact: investigators expect that this program will influence patients' choice of therapy, persistence with their preferred therapy, and lead to improved clinical outcomes. investigators believe that this product can be successfully operationalized in the clinic to establish a new paradigm of how providers can communicate personalized treatment options to patients across a broad range of diseases.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of crohn's disease based on standard clinical, radiographic, endoscopic, and histologic criteria * age 18 or older * fluent, english speaking * a candidate to receive immunomodulators or anti-tnf therapy based on their providers recommendation * not currently taking immunomodulators (6-mercapropurine, azathioprine, methotrexate) or anti-tnf agents (infliximab, adalimumab, certolizumab pegol) exclusion criteria: * participant in a pilot study/focus group for development of crohn's shared decision making program * currently taking any medication that is contraindicated to take together with an immunomodulator or anti-tnf agent * known intolerance to either immunomodulators or anti-tnf agents * lack of accessibility to e-mail for follow-up surveys

Keywords: crohn's disease shared decision making decision aid
an evaluation of folic acid to improve endothelial sensitivity to shear stress in seniors

Conditions: Healthy Aging; Aging; Menopause

Summary: the purpose of this study is to evaluate if folic acid improves endothelial sensitivity to shear stress in post-menopausal women.

cardiovascular diseases (cvd) have remained the leading cause of death globally for the last 15 years. considering that advancing age is the primary risk factor for cvd, an increasingly aging population is expected to result in unprecedented levels of cvd. it therefore remains crucial to develop effective prevention or treatment strategies to reduce the impending health and economic burden of cvd. exercise is arguably the best intervention for the prevention and/or treatment of cvd. a key adaptation underlying the cardiovascular benefits of exercise is to offset and reverse age-related reductions in vascular function. studies have demonstrated, at least in men, that active older adults demonstrate preserved vascular function relative to their sedentary peers and that exercise training interventions improve vascular function in previously sedentary older adults. however, these studies have almost exclusively been performed in men. in contrast, the few studies performed in older women consistently demonstrate that active women do not demonstrate preserved vascular function relative to their sedentary peers and that exercise training interventions do not improve vascular function in previously sedentary women. this observation has been attributed to the loss of oestrogens that accompanies menopause. although the mechanisms have not been fully elicited, it is possible that the loss of oestrogens desensitizes the endothelium to the physiological stimuli that result in improved vascular function with exercise training. indeed, exercise improves vascular function in previously sedentary older women when it is combined with oestrogen replacement. nevertheless, chronic oestrogen replacement therapy is not a viable intervention as it is associated with an increased risk of breast cancer. alternative solutions to restore the beneficial effects of exercise on vascular function in post-menopausal women are thus urgently needed. the overall objective of this project is to determine if folic acid, an over-the-counter supplement that has been shown to provide beneficial vascular adaptations, can be used to improve vascular function in post-menopausal women. it is hypothesized that folic acid will improve blood vessel function in post-menopausal women and age-matched males.

Eligibility criteria:
inclusion criteria: * ≥ 1-year amenorrhea * body mass index ≤ 30 kg/m2 * resting blood pressure \< 140 / \< 90 mmhg * non-smoker (≥ 1-year) exclusion criteria: * diagnosis of cardiac, vascular, respiratory, neurological or metabolic disease and/or a prescription of medications for the treatment of such diseases. * for female participants, hormonal replacement therapy within 1 year of enrolment in the study. * for female participants, having undergone an ovariectomy.

Keywords: postmenopausal women vascular health folic acid
late metabolic effects of metformin therapy in gestational diabetes

Conditions: Gestational Diabetes

Summary: metformin in widely used as the treatment of gestational diabetes. however, it is not known whether exposure to metformin in utero has late metabolic effects on the child. in this study the investigators investigate metabolism (oral glucose tolerance test, insulin, plasma lipoproteins, inflammation markers as well as body composition by dexa (dual energy x-ray absorption) and mri) in 9 year-old children whose mothers used either metformin of insulin during pregnancy.

gestational diabetes is usually managed with diet and insulin, if needed. however, oral metformin therapy has been also used to treat gestational diabetes and the short-term studies have shown that it is effective and also safe for the child. however, long-term studies of its effects are lacking. previously, several years ago, 217 pregnant women with gestational diabetes in turku and 100 such women in oulu, finland, were randomised to either insulin or metformin therapy to treat gestational diabetes. in those studies, the metformin therapy proved to be safe in the short-term. now these children are 5-9 years old. in the present study these children (as well as their mothers) are investigated when the children are 9 years old. the aim is to study whether the metformin given during the pregnancy has any metabolic effects on the child at 9 years of age. to do this these families are contacted by mail and asked to participate into the study. at 9 years of age, the following investigations will be made (after consent from the child and family): oral glucose tolerance test+insulin+c-peptide, plasma lipoproteins, adiponectin, pai-1 (plasminogen activator inhibitor-1), il-6 (interleukin-6), hs crp (high-sensitivity c-reactive protein), p-metabolomics, dexa, abdominal mri, wisc iv (wechsler intelligence scale for children iv)cognitive testing, brief questionnaire, questionnaire about diet and health habits. the study subjects will also be clinically examined and measured and blood pressure will be taken. all analyses are performed at the university hospital laboratory and radiology facilities using modern techniques. the amount of blood taken is limited and also radiation dose from dexa is very small. the data are kept behind lock and key. statistical analyses will be performed to study whether children exposed to metformin during pregnancy have any differences in their metabolism and well-being than those exposed to insulin. this study involves no new medical treatments to the study subjects.

Eligibility criteria:
inclusion criteria: * all children whose mothers used either metformin or insulin to treat gestational diabetes and were involved in the previous metformin study in turku or oulu, finland exclusion criteria: * severe congenital malformations
azd5438 in patients with advanced solid malignancies

Conditions: Neoplasms

Summary: purpose of this study is to assess the safety and tolerability of azd5438 given orally to patients with advanced solid malignancies a review of the emerging clinical tolerability and exposure data from this study in conjunction with preclinical and the available clinical pharmacodynamic data relating to azd5438, led to a decision by astrazeneca that the development of azd5438 as a potential anti-cancer agent would be discontinued.


Eligibility criteria:
inclusion criteria: * advanced solid malignancy * cancer refractory to standard treatments or for which no standard therapy exits exclusion criteria: * radiotherapy within 3 weeks of the start of treatment * investigational product within the last 3 weeks * systemic cytotoxic anti-cancer therapy within the last 3 weeks * any significant clinical disorder that makes it undesirable for the patient to participate

Keywords: advanced, solid, malignancies
high-intensity focused electromagnetic (hifem) field device in women after childbirth

Conditions: Muscle Tone Increased

Summary: evaluation of use of the high-intensity focused electromagnetic (hifem) field device in women after childbirth.


Eligibility criteria:
inclusion criteria: * non-breastfeeding women 3-36 months after childbirth * voluntarily signed informed consent form * bmi ≤ 30 kg/m2 * women of child-bearing potential are required to use birth control measures during the whole duration of the study * subjects willing and able to abstain from partaking in any treatments other than the study procedure to promote body contouring during study participation * subjects willing and able to maintain her regular (pre-procedure) diet and exercise regimen without effecting significant change in either direction during study participation exclusion criteria: * cardiac pacemakers * implanted defibrillators, implanted neurostimulators * electronic implants * pulmonary insufficiency * metal implants * drug pumps * application in the head area * application in the heart area * malignant tumor * fever * pregnancy * breastfeeding * following recent surgical procedures when muscle contraction may disrupt the healing process * application over areas of the skin which lack normal sensation * scars, open lesions and wounds at the treatment area * unrepaired abdominal hernia * patients after cesarean section delivery
evaluating clinical trial experiences of individuals with congestive heart failure

Conditions: Congestive Heart Failure

Summary: clinical trial participation has always been substantially skewed toward certain demographic groups. however, there has been little study on whether trial qualities impact participation in either a positive or negative way. the goal of this research is to identify the characteristics that consistently restrict patients' ability to participate in or complete a trial in which they were initially interested. this data will be evaluated via a number of demographic lenses in order to find trends that could benefit future congestive heart failure sufferers.


Eligibility criteria:
inclusion criteria: * lives in the united states * is 18+ years old * participant has a diagnosis of congestive heart failure * participant has enrolled in an interventional clinical for congestive heart failure (self-reported) exclusion criteria: * inability to perform regular electronic reporting * patient does not understand, sign, and return consent form * no diagnosis of congestive heart failure confirmed

Keywords: congestive heart failure heart failure
investigation on the practice status of emergency stuff

Conditions: Emergencies

Summary: what is the medical environment of the emergency department? is the practice status of emergency medical care good or bad? at present, there is no corresponding investigation and research on the current situation of emergency medical care in china. therefore, this study intends to conduct a cross-sectional survey of the current practice of emergency medical staff to understand the current situation of emergency medical care and provide a basis for the development and construction of the emergency department.

as the window department of the hospital, the emergency department is an important place for the rescue of critically ill patients. whether the emergency department can complete the rescue of various critically ill patients with high standards, high efficiency and high quality reflects the overall management level and technical capabilities of the hospital. with the development of society, the people's demand for emergency medical services is also increasing. therefore, it is important to strengthen the investment of manpower and material resources in the emergency department. since the outbreak of the new crown pneumonia epidemic, the emergency department has been the frontier of contact with the epidemic, and the busy emergency patients have faced greater risks and challenges. so, what is the medical environment of the emergency department? is the practice status of emergency medical care good or bad? at present, there is no corresponding investigation and research on the current situation of emergency medical care in china. therefore, this study intends to conduct a cross-sectional survey of the current practice of emergency medical staff to understand the current situation of emergency medical care and provide a basis for the development and construction of the emergency department.

Eligibility criteria:
inclusion criteria: * all hospitals with independent emergency departments in zhejiang province; * voluntary participation. exclusion criteria: * hospitals without independent emergency department.

Keywords: emergency department practice status doctors and nurses
rapid t-cell analysis test in patients with chronic hbv and hbv/hdv disease

Conditions: HBV; HBV/HDV

Summary: prospective, non-pharmacological, single-center, non-profit observational study. the study design allows longitudinal evaluation of the immune response during the natural history of the infection and/or treatment, correlating the data with the outcome of the disease and antiviral therapies, which will be collected as study variables from the source documents. the study population will be patients suffering from chronic hbv infection with or without hbv-hdv co-infection followed at the division of gastroenterology and hepatology of fondazione irccs ca' granda ospedale maggiore policlinico. the present study is part of an international cooperation project between the division of gastroenterology and hepatology, fondazione irccs ca' granda ospedale maggiore policlinico (milan, italy) and the duke-nus medical school, singapore, financed by a grant (project maeci-2023-23683653) and divided into two specific work packages: * wp 1 milan team (wp1.1 - clinical and virological phenotyping of chb and chd patients; wp1.2 - clinical evaluation of rapid hbv t cell test in chb and chd populations) * wp 2 singapore team (wp2.1 - applicability of the rapid t cell assay approach; wp 2.2 - optimization of the rapid t cell assay protocol) the primary objective of the study is to define the prevalence of specific t cell responses in patients with chronic hbv and hbv-hdv infection, through the application of a specific rapid t cell assay.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * ability to understand and sign the informed consent * chronic hbv infection or hbv-hdv co-infection defined by positivity of hbsag antigen (hbv) and hdv rna (hbv-hdv co-infection) for at least 6 months exclusion criteria: * co-infection with other hepatotropic viruses (hcv, hiv) * treatment with immunosuppressive/immunomodulatory drugs * other congenital and/or acquired immunodeficiency conditions