Kornimate/medical-research-clean huggingface dataset:
comparative evaluation of the thermal protection provided by submarine rescue suits: half suit versus full suit

Conditions: Cold Exposure, Hypothermia, Thermal Insulation, Immersion Suits, Submarine Evacuation

Summary: this study evaluated the thermal and functional performance of full-body versus half-body submarine escape immersion equipment (seie) suits during cold water immersion (\~16.5°c) and raft sitting. twenty submariners were divided into two groups.

this study investigates the performance of full-body versus half-body submarine escape immersion equipment (seie) suits under conditions simulating submarine emergencies in cold water (\~16.5°c). in such scenarios, rapid evacuation and prolonged exposure to cold water pose significant risks of hypothermia and impaired physical function. the aim was to assess and compare the thermal insulation and motor performance effects of both suit designs during water immersion and raft sitting. twenty healthy active-duty submariners (age 22 ± 1 years) participated, divided evenly into two groups (full suit vs. half suit). core temperature was monitored using ingestible sensors, and subjective cold sensation was assessed regularly throughout immersion and raft sitting. additional outcome measures included fine motor dexterity (assembling shackles) and handgrip strength, recorded before and after exposure. the experimental protocol involved one session per participant. anthropometric data were collected, and subjects underwent a controlled immersion and raft sitting protocol using calibrated thermal equipment. motor function tasks were standardized and repeated to control for learning effects. statistical analysis included non-parametric repeated measures tests with appropriate corrections for multiple comparisons.

Eligibility criteria:
inclusion criteria: healthy active-duty submariners male participants aged 20-25 years no history of cardiovascular, respiratory, or neurological disorders not acclimatized to cold environments or cold water exposure provided written informed consent medically cleared for cold water immersion by a physician prior to participation - exclusion criteria: history of cardiovascular, respiratory, metabolic, neurological, or musculoskeletal disorders regular exposure to cold environments or cold water (cold-acclimatized individuals) use of medications that could affect thermoregulation or neuromuscular function any skin conditions that may be aggravated by cold water immersion inability to provide informed consent failure to pass pre-exposure medical examination by a study physician -
clozapine-associated infection

Conditions: Infections

Summary: perform a study in vigibase® to assess if clozapine was associated with an over-reporting of infections and to characterize those infections. the investigators also decided to assess the dose dependency associated with those infections.


Eligibility criteria:
inclusion criteria: * case reported in the world health organization (who) database of individual safety case reports to 11/04/2023 * adverse events reported were including the meddra terms: infections (soc) exclusion criteria: chronology not compatible between the drug and the toxicity
clinical evaluation of navigated 3d ultrasound multicentre study

Conditions: Brain Neoplasms

Summary: 3d ultrasound is a new modality used in image guided neurosurgery. a multicentre study is started for the evaluation of this tool as a means for achieving total resection of brain tumors at greater safety.

the degree of resection as judged by the surgeon is recorded at the end of surgery for each patient, and then compared with the postoperative mri. neurological status before and after surgery, qol before surgery and at follow-up as well as survival is recorded.

Eligibility criteria:
inclusion criteria: * supratentorial glioma exclusion criteria: * not willing to participate in study

Keywords: neuronavigation ultrasound brain tumour surgery biopsy histopathology intraoperative imaging 3d ultrasound imaging
bench study of transcutaneous hydrocephalic shunt flow sensor alignment accuracy and repeatability

Conditions: Hydrocephalus

Summary: the study hypothesis is that nurses and doctors can use a transcutaneously powered ultrasonic flow sensor to make repeatable and accurate hydrocephalic shunt flow measurements. the study participants will align the flowmeter probe with a flow sensor hidden under a thick saline pad that simulates skin. a hidden pump will provide a known flow through the flow sensor as the participants make their measurements. each participant will repeat these measurements over a period of weeks, and the data will tell whether operator skill influences flow measurement accuracy.

the study hypothesis is that a transcutaneously powered ultrasonic flow sensor for hydrocephalic shunts can be repeatedly and accurately read by medical personnel ranging from nurses to senior neurosurgeons. the test will involve a prototype implantable hydrocephalic shunt flow sensor and readout electronics. the readout electronics use a pickup coil to transcutaneously operate the sensor once the coil is aligned with sensor's inductive coupling coils. during the test, the shunt flow sensor will be hidden under a thick saline gel pad whose thickness approximates the skin thickness of an older pediatric patient. a syringe pump will provide a known flow rate through tubing connected to the sensor, but the study participants will not know the pump flow setting. three neurosurgeons and six floor nurses will perform this study. each will use the transonic flowmeter readout to align the pickup coils of the flowmeter with the hidden sensor to make flow measurements. each participant will repeat this measurement multiple times over non-consecutive days. the recorded data will quantify measurement accuracy and repeatability between different operators, and will determine whether operator skill influences flow measurement accuracy.

Eligibility criteria:
inclusion criteria: * neurosurgeon * nurse exclusion criteria: * none

Keywords: hydrocephalus shunt dysfunction shunt flow
corneal endothelium morphology and central thickness in type ii diabetes mellitus and normal subjects

Conditions: Corneal Dystrophy

Summary: the purpose of this study is to compare corneal endothelium morphology and central thickness in type ii diabetes mellitus and normal subjects with special reference to glycemic status.

diabetes might influence the health of the corneal endothelium. older studies have presented different results and the glycemic status of the patients have not been reported. in this study we examine the corneal endothelium morphology and central thickness in type ii diabetes mellitus and normal subjects with modern specular microscopy. each patient and control is examined once ("entry to study").

Eligibility criteria:
inclusion criteria: * type ii diabetes (diagnose confirmed by general practitioner) * controls with no diabetes (confirmed by blood testing). exclusion criteria: * glaucoma * uveitis (current or previous) * corneal scaring * previous eye surgery

Keywords: corneal endothelium diabetes mellitus corneal thickness
the application of kinesio taping technique in the early upper limb functional activities induction of hemiplegic patients after stroke

Conditions: Cerebral Infarction Recovery; Rehabilitation Treatment; Upper Extremity Motor Function; Emg Biofeedback

Summary: 1. to observe the inducing and promoting effect of kinesio taping technique on the recovery of upper limb function in early-stage stroke patients. 2. to compare the different effects of kinesio tape and sports white tape on the induction and promotion of limb function in patients. 3. to verify that kinesio taping technique is a safe and promotable technical means for stroke patients.


Eligibility criteria:
inclusion criteria: 1. the subjects voluntarily participated in the experiment and signed informed consent 2. diagnosed as a stroke patient 3. no other major cardiovascular and cerebrovascular diseases 4. first new stroke 5. after evaluation by evaluators, subjects had brunnstrom stage \< 3 exclusion criteria: 1. the subject's compliance was poor 2. increased muscle tone in the affected upper extremity 3. subjects with skin allergies 4. those who did not receive continuous treatment during the experiment

Keywords: ischemia necrosis brain infarction brain ischemia cerebrovascular disorders brain diseases central nervous system diseases nervous system diseases stroke vascular diseases cardiovascular diseases cerebral infarction infarction
eszopiclone for sleep disturbance and nightmares in post-traumatic stress disorder

Conditions: Post-Traumatic Stress Disorders

Summary: the purpose of this study is to obtain data investigating the safety and efficacy of eszopiclone for the treatment of post-traumatic stress disorder (ptsd)-related sleep disturbance and the impact of improved sleep with eszopiclone treatment on neuroendocrine correlates of ptsd. the investigators hypothesize that eszopiclone will be significantly more effective than placebo and well tolerated for ptsd-related sleep disturbance, improvement in sleep will be associated with improvement in overall ptsd symptoms, and patients with ptsd-related sleep disturbances will have abnormal levels of stress hormones.

post-traumatic stress disorder (ptsd) is characterized by three symptom groupings: re-experiencing symptoms including flashbacks, nightmares, and intrusive memories; physiological hyperarousal; and avoidance symptoms. of the three major categories of symptoms in ptsd listed by the diagnostic and statistical manual of mental disorders, sleep-related problems are listed in two of them: difficulty falling asleep is considered an aspect of hyperarousal symptoms, and nightmares are a type of re-experiencing symptom. both are found commonly in ptsd. little is known about the relationship of neuroendocrine dysregulation in ptsd and sleep disturbance. it is possible that successful treatment of sleep disturbance in ptsd may alter an abnormal stress hormone pattern. the novel cyclopyrrolone hypnotic eszopiclone thus presents an intriguing opportunity to examine the treatment of sleep disturbances and nightmares in ptsd. this study will determine the safety, efficacy and impact on neuroendocrine parameters of eszopiclone compared to placebo for sleep disturbance and overall ptsd symptoms in individuals with ptsd and reported sleep disturbance.

Eligibility criteria:
inclusion criteria: * male or female outpatients 18-64 years of age with a primary diagnosis of ptsd as defined by dsm-iv criteria with associated sleep disturbance exclusion criteria: * pregnant women, lactating women, and women of childbearing potential who are not using medically accepted forms of contraception. * concurrent use of other psychotropic medications, other than antidepressants at stable dose for at least 4 weeks prior to randomization * serious medical illness or instability * seizure disorders with the exception of a history of febrile seizures if they occurred during childhood * concurrent psychotherapy initiated within one month of randomization or ongoing psychotherapy of any duration directed specifically toward treatment of ptsd and/or sleep disturbance * diagnosis of schizophrenia, mental retardation, ocd, organic medical disorders or bipolar disorder, eating disorders in the past 6 months, alcohol or substance abuse in the past 3 months, or dependence within the past 6 months. * patients with significant suicidal ideation or who have enacted suicidal behaviors within 6 months prior to intake

Keywords: ptsd sleep disturbance eszopiclone double-blind crossover
phase ii trial of a 96-hour continuous infusion of paclitaxel followed by cisplatin for patients with stage iii/iv and relapsed nsclc

Conditions: Carcinoma, Non-Small-Cell Lung; Lung Neoplasms

Summary: this is a phase ii study of paclitaxel (taxol r) administered as a 96-hour (4 day) continuous infusion followed by a bolus of cisplatin for previously untreated patients with stage iii/iv or relapsed non-small cell lung cancer (nsclc). the goal of this phase ii study is to determine the response rate of this infusional paclitaxel and bolus cisplatin regimen in patients with advanced nsclc.

this is a phase ii study of paclitaxel (taxol r) administered as a 96-hour (4 day) continuous infusion followed by a bolus of cisplatin for previously untreated patients with stage iii/iv or relapsed non-small cell lung cancer (nsclc). the goal of this phase ii study is to determine the response rate of this infusional paclitaxel and bolus cisplatin regimen in patients with advanced nsclc. in addition, the plasma levels of paclitaxel will be measured, and the in vitro paclitaxel chemosensitivity of the tumor cells from as many patients as possible will be determined. this will allow further study of the relationship between in vitro drug sensitivity, achievable plasma concentrations of paclitaxel, and patients' response to therapy.

Eligibility criteria:
disease characteristics: histologically confirmed non-small cell lung cancer, including: squamous cell carcinoma, adenocarcinoma, large cell carcinoma, mixed histologies in the absence of a predominant small cell component. eligible stages include: stage iv, stage iiia/b ineligible for resection or radiotherapy, postsurgical recurrence that is histologically or cytologically proven. cns metastases allowed provided: radiotherapy completed prior to entry. no requirement for concurrent steroids. no carcinomatous meningitis. no epidural metastases. measurable disease not required. prior/concurrent therapy: biologic therapy: not specified. chemotherapy: no prior chemotherapy for lung cancer. endocrine therapy: not specified. radiotherapy: no prior chest irradiation for lung cancer. surgery: prior surgery allowed. patient characteristics: age: 18 and over. performance status: ecog 0-2. hematopoietic: absolute granulocyte count greater than 2,000. platelet count greater than 100,000. hepatic: bilirubin no greater than 1.5 mg/dl. renal: creatinine no greater than 1.5 mg/dl. cardiovascular: no chf unless fully compensated. no second- or third-degree heart block. no uncontrolled, symptomatic atrial dysrhythmia except sinus bradycardia. no sustained ventricular tachycardia. no mi within 3 months. other: no uncontrolled infection unless due to an obstructed bronchus. no major psychiatric problems requiring hospitalization. no psychotropic medications such as phenothiazines. no contraindication to transfusion, if required. no second malignancy within 5 years except: nonmelanomatous skin cancer. in situ cervical cancer. no pregnant or nursing women. effective contraception required of fertile patients.

Keywords: chemotherapy in vitro testing infusional lung neoplasm pharmacokinetics
treatment resistant depression and insomnia in older veterans

Conditions: Treatment Resistant Depression; Insomnia

Summary: the purpose of this pilot study is to obtain information about older veterans' preferences for treatment of depression and insomnia and to pilot test the feasibility and clinical effect of brief behavioral treatment for insomnia (bbti) bbti for older veterans living with treatment resistant depression (trd) and insomnia.

quantitative and qualitative methods will be used to obtain information to aid in developing treatment approaches appropriate for older veterans with trd and insomnia. qualitative data will be gathered to better understand veterans' preferences for treatment approaches, particularly relating to preference for pharmacotherapy versus augmentation with a behavioral intervention such as bbti. using a randomized controlled trial (rct) design, we will test whether augmentation with bbti will be acceptable to older veterans and improve treatment response in those whose depression has not improved with antidepressant pharmacotherapy alone and assess for an association between preference and treatment response. our aims and hypotheses are: aim 1: to characterize the depression, insomnia, and relevant clinical and neuropsychiatric characteristics of older veterans with trd. h1a: in veterans with trd, antidepressant history form (athf) scores will have a positive association with montgomery-asberg depression rating scale (madrs) scores. h1b: in veterans with trd, madrs scores will have a positive association with insomnia severity index (isi) scores. aim 2: perform qualitative interviews in older veterans to collect information about their views of their depression and insomnia and attitudes and preferences for treatment of both depression and insomnia. aim 3: to examine the feasibility of using bbti to treat veterans with trd and insomnia. h3a: use of bbti will be feasible in older adults with trd as defined by acceptability and retention. aim 4: to determine if antidepressant augmentation with bbti leads to improvement in scores on madrs and isi scales in older veterans receiving bbti versus those receiving only antidepressant optimization. h4a: augmentation with bbti will improve both phq-9 and isi scores relative treatment with antidepressant alone.

Eligibility criteria:
* inclusion criteria: * age ≥ 60 * diagnosis of major depressive disorder (mdd) * diagnosis of insomnia disorder * must have failed ≥ 1 antidepressant trial * exclusion criteria: * lifetime/current bipolar i/ii diagnosis * lifetime/current schizophrenia spectrum disorder diagnosis * substance use disorder within past 3 months * high suicide risk that cannot be safely managed * untreated obstructive sleep apnea (osa) * restless legs syndrome * rapid eye movement (rem) sleep behavior disorder * active or untreated post traumatic stress disorder (ptsd)
pregnant women with and without crohns disease to explore the role of plastics and toxins in intestinal inflammation

Conditions: Crohns Disease; Pregnancy; Inflammatory Bowel Disease

Summary: the planet study aims to determine the impact of microplastics on intestinal inflammation and gut microbiome in order to understand the role of this pollutant on the risk of developing inflammatory bowel disease (ibd) as well as other diseases. with this information, the researchers hope to characterize better the role of environmental pollutants on ibd and develop novel strategies towards prevention.

inflammatory bowel disease (ibd), including crohn's disease (cd) and ulcerative colitis (uc), is a chronic, progressive inflammatory disease of the intestinal tract. the etiology of ibd is not well understood, but believed to result from a complex relationship between genetics, environment, and gut microbiome alterations, resulting in a self-perpetuating, abnormal mucosal immune response. the incidence of ibd is rising in developing and recently developed countries, highlighting the importance of environmental exposures in determining disease risk. microplastics, defined as plastic particles \<5 mm in size, are ubiquitous pollutants with unclear implications towards human health. emerging studies indicate substantial disruption of intestinal immune function and a proinflammatory milieu due to microplastics. therefore, identifying, and characterizing microplastics in stool samples of individuals with cd alongside alterations in microbiome and calprotectin, which are events that occur prior to cd onset, is the initial step in exploring the impact of microplastics on ibd. moreover, cd affects women during their reproductive years and 25% become pregnant after diagnosis. given that maternal ibd diagnosis is one of the major risks of future ibd in offspring, it is critical to better understand if babies born to mothers with ibd have higher content of microplastics or other toxins in the stools and whether these levels correlate with those of their mothers during pregnancy.

Eligibility criteria:
inclusion criteria: * the ability to sign and date an informed consent form * be pregnant, or wishing to become pregnant in the near future and enroll the infant that the individual is pregnant with * aged 18 or older * english-speaking (this observational study uses non-validated questionnaires that are only available in english) * of any ethnicity * be a spouse, related household member (sibling, parent, etc.) or a child of an enrolled pregnant person exclusion criteria: * individuals who are unable to give informed consent * be diagnosed with a pregnancy complication, such as intrauterine fetal demise/stillbirth, preeclampsia, hyperemesis gravidarum, or have an active infection, including chorioamnionitis or sepsis.

Keywords: microplastics nanoplastics pregnancy pollution environmental pollutants
asha bangladesh--integrated intervention to address poverty and depression

Conditions: Depression; Economic Vulnerability

Summary: the goal of this randomized controlled trial is to compare the impact of an integrated intervention combining poverty alleviation and depression treatment to depression treatment alone, in low income rural bangladeshi women with depression. the main question\[s\] it aims to answer are: 1) whether adding poverty alleviation to depression treatment in an integrated intervention improves depression outcomes at 24 months, as assessed by depressive symptoms and by the presence or absence of relapse; and 2) whether adding poverty alleviation to depression treatment improves implementation outcomes including treatment uptake and retention. participants in both arms will participate in interviews at 6,12,18 and 24 months.


Eligibility criteria:
inclusion criteria: 1. married women; 2. age 18-75; 3. fluent in bengali); 4. meets criteria on an economic vulnerability index 5. \>=10 on the patient health questionnaire (phq-9 depression scale at baseline exclusion criteria: 1. inability to provide informed consent; 2. plans to travel for \> 1 month during 24 m period. 3. inability to participate in the study for any other reason

Keywords: depression treatment cash transfer problem management plus poverty alleviation
study on therapeutic effect of treating mental stress induced myocardial ischemia

Conditions: Theraphy of Chinese Traditional Medicine

Summary: this study aims to discuss whether the combined treatment of traditional chinese medicine (tcm) and western medicine for mental stress induced myocardial ischemia (msimi) does effect, namely the conventional therapy for coronary heart disease( chd) combining with tcm - xinkeshu tablets.

a large number of evidence-based medical researches have proven that bad mood and mental stress are related to poor prognosis. having recognized that acute emotional stress can induce cardiovascular events, many clinical tests of mental stress have been carried out to observe the correlation between emotional stress and cardiac damage, which ultimately lead to the formalization of the concept of mental stress induced myocardial ischemia(msimi). in the past 3 decades, it has been evidenced that mental stress is internally related to myocardial ischemia. according to current studies, over 70% patients with stable coronary heart disease have msimi and are exposed to three or four times higher risk of cardiovascular events. however, few articles are about the therapeutic effect of msimi treatment. this study aims to discuss whether the combined treatment of traditional chinese medicine (tcm) and western medicine for msimi does effect, namely the conventional therapy for chd combining with tcm - xinkeshu tablets.

Eligibility criteria:
inclusion criteria: 1. above 18 years old, 2. having coronary stenosis (\> 70%) measured by coronary arteriography, 3. with medical history of myocardial infarction or revascularization procedures, 4. or with sufficient proof for having chd. exclusion criteria: 1. patient age younger than 18, 2. clearly impaired cognitive function, 3. damage of functions of vital organs, 4. suicidal ideation, 5. mental diseases treated with selective serotonin reuptake inhibitor (ssri)

Keywords: traditional chinese medicine