Kornimate/medical-research-clean huggingface dataset:
intraarticular injections of the hip and knee with triamcinolone versus ketorolac: a randomized controlled trial

Conditions: Arthritis Knee; Arthritis of Hip

Summary: clinicians commonly utilize intraarticular injections to treat symptomatic primary arthritis. steroid injections are common yet have immune-modulating effects and can alter gene expression which may delay definitive arthroplasty and further damage cartilage. non-steroidal anti-inflammatory (nsaid) injections may offer a safer profile due to their differing mechanism of action; however, there is a relative dearth of information regarding their efficacy. this non-inferiority study compares the effectiveness of triamcinolone versus ketorolac in treating symptoms of moderate to advanced primary osteoarthritis of the hip and knee.


Eligibility criteria:
inclusion criteria: * symptomatic, radiographically proven degenerative joint disease in the hip or knee exclusion criteria: * recent injection in the hip or knee within the previous 3 months * history of traumatic osteoarthritis or ligamentous reconstruction * chronic narcotic use * history of inflammatory or neuropathic arthropathy * pregnant and/or nursing women * allergy or strong reaction to study medications
use of high-dose radiation therapy plus chemotherapy to improve the likelihood of surgical treatment in patients with locally advanced pancreatic cancer

Conditions: Pancreatic Cancer

Summary: this study is being done to test whether receiving a dose of radiation that is higher than the standard dose, in combination with chemotherapy, improves the chance of becoming a candidate for surgery and improves the chance of extending the patient's life.


Eligibility criteria:
inclusion criteria: * histologically or cytopathologically confirmed adenocarcinoma of the pancreas. * locally advanced, unresectable pancreatic cancer defined on post-induction chemotherapy ct as having tumor involvement of \>180° (\> 50%) of the circumference of the superior mesenteric artery (sma) or celiac axis, unreconstructable superior mesenteric vein (smv) or pv involvement. * no evidence of distant metastasis either prior to or after induction chemotherapy. * completion of at least 3 months of standard induction chemotherapy for lapc, which may include folfirinox or gemcitabine and nab-paclitaxel, within 6 weeks of enrollment. * for patients currently receiving investigational agents, a washout of at least 2 weeks or 5 half-lives of experimental agent are required prior to the start of rt. * age ≥18 years. * kps 70-100. * patients must have acceptable organ and marrow function as defined below: * leukocytes \>3,000/µl * absolute neutrophil count \>1,500/µl * platelets \>75,000/µl * total bilirubin within 2 x upper limit of normal * ast (sgot)/alt (sgpt) \ 60 ml/min for patients with creatinine levels above institutional normal * any systemic therapy associated toxicity should be grade 1 or less * ability to understand and the willingness to sign a written informed consent document. exclusion criteria: * patients who have borderline resectable disease using nccn definition. * patients who have had prior abdominal radiotherapy. * uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, or cardiac arrhythmia. * patients who are not surgical candidates due to medical co-morbidities. * patients in whom iodine contrast is contraindicated. * pregnant and breastfeeding women are excluded. women of child-bearing potential who are unwilling or unable to use an acceptable method of birth control to avoid pregnancy for the entire study period and for up to 4 weeks after the study are excluded. this applies to any woman who has experienced menarche and who has not undergone successful surgical sterilization or is not postmenopausal (defined as amenorrhea for at least 12 consecutive months, or women on hormone replacement therapy with serum fsh levels greater than 35 miu/ml. a negative serum pregnancy test must be obtained within 14 days prior to the start of study therapy in all women of child-bearing potential. male subjects must also agree to use effective contraception for the same period as above.

Keywords: ablative irradiation 18-090
surveillance study of novorapid® for new drug re-examination

Conditions: Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2

Summary: this study is conducted in asia. the aim of this study is to observe the safety and efficacy of insulin aspart (novorapid®) administered via vial and three different devices.


Eligibility criteria:
inclusion criteria: * subjects with diabetes mellitus (type 1, type 2, or gestational) prescribed with insulin aspart (novorapid®)
use of teicoplanin on a three-weekly administration in the infectious diseases unit

Conditions: Comparison of Teicoplanin Used Three Times a Week in DSIs vs NDISs

Summary: teicoplanin is an antibiotic belonging to the class of glycopeptides, in use since 1986. like its older "classmate" vancomycin, it inhibits protein synthesis by interfering with the synthesis of peptidoglycan, and is active on gram-positive bacteria such as staphilococcus spp (including mrsa), streptococcus spp and enterococcus spp (both faecalis and faecium). teicoplanin is characterized by poor gastrointestinal absorption, which requires intramuscular or intravenous administration; has a binding to plasma proteins greater than 90%; and a high volume of distribution. it reaches high levels in deep tissues (bone, abdomen, lung, kidney, heart) on the contrary it has poor penetration at the central nervous system level; it is approved for the treatment of skin and soft tissue infections, osteo-articular infections, pneumonia, endocarditis, complicated urinary tract infections, peritonitis and bacteremia associated with the aforementioned clinical conditions. furthermore, teicoplanin has a markedly long half-life (between 30 and 180h) which allows it to be administered even every 48-72h. dose and duration of treatment should be adjusted according to the location and severity of the infection and based on patient characteristics such as renal function. the possibility of carrying out therapeutic drug monitoring (tdm) allows maintaining plasma levels adequate for the treatment of deep infections (e.g. \>20 mg/l for endocarditis) and avoiding overdose. thanks to the possibility of administering teicoplanin on a three-weekly schedule, patient access to hospital is further reduced. the investigators therefore propose a retrospective study to evaluate the clinical effectiveness of teicoplanin therapy according to a three-weekly scheme by comparing its use in the treatment of deep infections (deep seated infections - dsis) and superficial infections (non-deep seated infections - ndsis).


Eligibility criteria:
inclusion criteria: * age \>18 years; * patients with documented gram-positive infection sensitive to teicoplanin; * patients who have received at least 4 doses of teicoplanin on a three-weekly schedule, as monotherapy or associated with other antibiotics exclusion criteria: * hospitalized patients * patients who have received less than 4 doses of teicoplanin for any cause.
blood pressure responses to different exercise modes in coronary artery disease

Conditions: Coronary Artery Disease

Summary: the purposes of this study were to compare blood pressure responses of the same target heart rate on different exercise modes in patients with coronary artery diseases (cad) and to compare the effects of blood pressure responses after exercise training. the investigators will recruit 30 subjects with cad who are referred to phase ii cardiopulmonary rehabilitation exercise training. the subjects performed the treadmill or stationary bicycle exercise randomly.

considering cardiopulmonary rehabilitation intensity is often setting by heart rate clinically, and only few study focused on exercise responses patients with cad, the purposes of this study were to compare blood pressure responses of the same target heart rate on different exercise modes in patients with cad and to compare the effects of blood pressure responses after exercise training. this is a crossover trial study. the investigators will recruit 30 subjects with cad who are referred to phase ii cardiopulmonary rehabilitation exercise training. after at least 3 times of familiar with the cardiopulmonary rehabilitation training machine, the subjects performed the treadmill or stationary bicycle and exercise to personalized target heart rate for 10 minutes, take a rest until the heart rate recover to the resting heart rate, and then repeated the exercise in another exercise mode. the test order will be random. after at least 12 times of cardiopulmonary rehabilitation training, the test will be performed again.

Eligibility criteria:
inclusion criteria: * patients with coronary artery diseases who are referred to phase ii cardiopulmonary rehabilitation exercise training. exclusion criteria: * patients with non-coronary artery diseases * atrial fibrillation * neurological or musculoskeletal problems

Keywords: coronary artery disease blood pressure rehabilitation exercise mode
using the gtos to stratify the mortality risk of adult trauma patients

Conditions: Trauma Injury

Summary: trauma significantly impacts both short- and long-term health outcomes, resulting in substantial mortality. early identification and risk stratification in trauma patients are crucial for timely medical interventions. the geriatric trauma outcome score (gtos), designed by incorporating age, the injury severity score (iss), and the need for packed red blood cell transfusion, has emerged as a valuable prognostic tool for elderly trauma patients, but its applicability to general trauma patients remains underexplored.


Eligibility criteria:
inclusion criteria: * the study includes all patients aged equal to or over twenty who had trauma. exclusion criteria: * patients with burns. * patients with hangings. * patients with drowning. * patients with with unavailable laboratory data.
the advocate study

Conditions: Ostomy

Summary: hollister incorporated is studying stoma related cost of care related to a new ostomy skin barrier that is designed to maintain adhesive properties and good peristomal skin health compared to other currently marketed barriers.


Eligibility criteria:
inclusion criteria: ostomy patients who: * have healthy peristomal skin * are within 12 weeks post op exclusion criteria: ostomy patients who: * have a fistula, wound, lesion or suspected infection in the peristomal area * are in-patient in healthcare facility
prediction of 30-day readmission using machine learning

Conditions: Infection; Heart Failure; Chronic Obstructive Pulmonary Disease; Asthma; Gout Flare; Chronic Kidney Diseases; Hypertensive Urgency; Atrial Fibrillation Rapid; Anticoagulants; Increased

Summary: this is a retrospective observational study drawing on data from the brigham and women's home hospital database. sociodemographic and clinic data from a training cohort were used to train a machine learning algorithm to predict the likelihood of 30-day readmission throughout a patient's admission. this algorithm was then validated in a validation cohort.


Eligibility criteria:
was a subject in the brigham and women's home hospital study and has a completed record in the study's database.
effects of ghrelin on the sleep-eeg and nocturnal secretion of hormones

Conditions: Healthy; Major Depression

Summary: ghrelin, an acylated peptide consisting of 28 amino acids, is the endogenous ligand of the growth hormone secretagogue receptor (ghs-r). it is synthesized predominantly in the stomach but has been also identified in a variety of other organs. alike, a wide range of central and peripheral endocrine and non-endocrine actions has been described, e. g. being a releasing factor of growth hormone, prolactin and acth, a modulator of cell proliferation and apoptosis, a regulator of sleep-wake regulation, and a orexigenic hormone. aims of this study are: a) to determine the effect of exogenous ghrelin on sleep-eeg variables and hormones of the hypothalamic-pituitary-adrenocortical (hpa) axis, the gonadotropic axis and the hypothalamic-pituitary-gonadal axis in healthy subjects of both genders (age groups: 20-30, 35-45, 60-70 years). b) to determine the effect of exogenous ghrelin on sleep-eeg variables and hormones of the hpa axis, the gonadotropic axis and the hypothalamic-pituitary-gonadal axis in patients with major depression (age range: 20-65 years).


Eligibility criteria:
inclusion criteria: * healthy females and males * male and female patients with major depression exclusion criteria: * life time or family history of psychiatric or neurological disorders * sleep disturbances * shift work * any current disease * any medication * long distance flight within 3 months prior to study entry * smoking * any medication during the week prior to study entry * any current disease other than major depression
effects of black cohosh on menopausal hot flashes

Conditions: Postmenopause; Hot Flashes; Osteoporosis, Postmenopausal

Summary: this study will assess whether treatment with black cohosh is effective in reducing the frequency and intensity of menopausal hot flashes. in addition, this study will determine whether or not black cohosh reduces the frequency of other menopausal symptoms and improves quality of life.

most american women will spend the last third of their lives post-menopause. during this time, chronically low levels of steroidal estrogens may lead to a number of short and long-term medical sequelae such as hot flashes, vaginal dryness, heart disease, and osteoporosis. while some physicians believe that demonstrated beneficial effects of estrogen, particularly on the cardiovascular and skeletal systems, warrant the taking of hormone therapy from menopause on, many women choose not to take estrogen replacement therapy (ert) and are increasingly exploring alternative approaches to ert. for centuries, black cohosh (cimicifuga racemosa) has been used worldwide for women's health. despite its long-standing use, studies of black cohosh have yielded conflicting data, in part because of lack in study design rigor and the short duration of studies to date. the primary aim of this study is to correct past shortcomings in study design to determine whether treatment with black cohosh is effective in treating menopausal symptoms. participants in this study will be given black cohosh for a 12-month period. potential mechanisms of action of black cohosh will be examined by quantifying the levels of sex hormones, including estradiol, estrone, fsh, and lh. because black cohosh may act as an estrogenic agent, the effect on endometrium will be evaluated by sonogram and by monitoring the incidence of adverse events and compliance with the study.

Eligibility criteria:
inclusion criteria: * resident of the new york metro area * postmenopausal * weight within 90% to 120% of ideal body weight

Keywords: menopause hot flashes osteoporosis postmenopausal
the effects of gevokizumab in corticosteroid-resistant subjects with autoimmune inner ear disease

Conditions: Autoimmune Inner Ear Disease

Summary: the purpose of this study is to determine if gevokizumab therapy may be an alternate therapy in patients with steroid resistant autoimmune inner ear disease.


Eligibility criteria:
inclusion criteria: * autoimmune inner ear disease with active deterioration in at least one ear * failure to respond to a trial of high-dose corticosteroid therapy * contraceptive measures adequate to prevent pregnancy during the study exclusion criteria: * evidence of retrocochlear pathology (vestibular schwannoma) or inner ear malformation (mondini malformation or enlarged vestibular aqueduct) * history of active or chronic infections * currently receiving, or having received treatment for a malignancy in the past three years * hearing loss that coincides with significant, disabling episodes of vertigo * history of allergic or anaphylactic reactions to monoclonal antibodies * female subjects who are pregnant, planning to become pregnant, have recently delivered, or are breast-feeding other protocol-defined inclusion/exclusion criteria may apply

Keywords: autoimmune inner ear disease inner ear disease meniere's disease sudden sensorineural hearing loss
forearm immobilization, metabolic health, and muscle loss

Conditions: Healthy

Summary: the present study will investigate the impact of altered substrate availability on muscle atrophy, insulin sensitivity and muscle protein synthesis following short-term forearm immobilization

thirty-six healthy young volunteers will undergo 2 days of forearm immobilization combined with ingestion of one of two drug or placebo. before and after immobilization, they will receive a stable isotope tracer infusion (5.5 h) combined with repeated blood and muscle sampling under insulin clamp conditions, in order to measure insulin sensitivity and muscle protein synthesis in the fasted and fed state.

Eligibility criteria:
inclusion criteria: * males and females 18-40 years of age * body mass index between 18 and 27 exclusion criteria: * any diagnosed metabolic impairment (e.g. type 1 or 2 diabetes) * any diagnosed cardiovascular disease * hypertension (≥140 mmhg systolic and/or ≥90 mmhg diastolic) * chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices) * regular use of nutritional supplements * metallic implants * a personal or family history of thrombosis, epilepsy, seizures or schizophrenia * any previous motor disorders * any known disorders in lipid metabolism * any known disorders in muscle metabolism * known allergy for acipimox, beta agonist, or other substances in the tablets * known sensitivity for sympathomimetic drugs * known hypokalaemia * presence of an ulcer in the stomach or gut and/or strong history of indigestion * known severe kidney problems * pregnancy * unable to give consent
wb-ems increase energy expenditure at rest and during uphill walking exercise

Conditions: Sports Physical Therapy

Summary: whole-body electrical stimulation (wb-ems) has become increasingly popular as a tool to provide additional benefits compared to conventional exercise. however, the effects of the different electrical parameters on energy expenditure (ee) and respiratory exchange ratio (rer) remain poorly understood. this study aims to determine and compare the effects of different electrical frequencies applied with wb-ems in ee and rer at supine resting and during uphill walking exercise

obesity is a critical public health problem worldwide since it is a risk factor for cardiovascular diseases and mortality. increased body weight and obesity are the results of an imbalance between energy intake and energy expenditure (ee). body weight regulation and obesity are highly influenced by different factors such as genetic, physiology, and socioeconomics. it is well known that physical exercise is an effective strategy to increase ee, improve body composition, physical fitness, and cardiometabolic risk factors. unfortunately, the principal barriers to abstaining from exercise are time constraints, the risk of injuries, and the lack of enthusiasm observed during the exercise sessions. in this context, whole-body electromyostimulation (wb-ems) training is becoming increasingly popular worldwide as a potential and attractive alternative to traditional training methods to increase ee. the present study aimed to determine and compare the effects of different electrical frequencies applied with wb-ems in ee and rer at supine resting and during uphill walking exercise.

Eligibility criteria:
inclusion criteria: * (i) no previous experience with wb-ems training * (ii) having a stable body weight (variation of \<5 kg in body weight over the previous 3 months) * (iii) normal weight (body mass index (bmi) between 18.5-25.0 kg/m2) exclusion criteria: * (i) suffering from any health problem that might be aggravated by exercise or any contraindications for wb-ems, such as total endoprosthesis, epilepsy and abdomen/groin hernia * (ii) taking medications * (iii) chronic metabolic disease or cancer

Keywords: electrical stimulation energy expenditure obesity impulse intensities impulse frequencies
iv ibuprofen for the prevention of post-ercp pancreatitis

Conditions: Post-ERCP Acute Pancreatitis

Summary: endoscopic retrograde cholangiopancreatography (ercp) is an advanced endoscopic technique utilized to diagnose and treat pathologic conditions involving the ducts draining the liver and pancreas. post-ercp pancreatitis (pep) is the most common complication following ercp and occurs in approximately 11% of children undergoing the procedure. by definition it leads to prolongation of hospital stay or delays in care and rarely can result in long-term morbidity or even death. recent adult trials have demonstrated prevention of pep with administration of rectal nonsteroidal anti-inflammatory drugs (nsaids). to date, no studies have been performed in children thus no "gold standard" or even commonly accepted method of preventing pep in the pediatric population exist. studying an iv nsaid such as ibuprofen has distinct advantages over rectally administered nsaids in the pediatric population in that it would allow for more consistent weight based dosing and would have more predictable absorption compared to suppository. thus, this project proposes a pilot study evaluating the effectiveness of iv ibuprofen at preventing pep in the pediatric population. the design of the proposed study is a prospective randomized double-blind trial comparing iv ibuprofen to placebo controls (normal saline) at the time of procedure in patients undergoing ercp at children's medical center dallas over a two-year period. the primary outcome measurement will be development of pep. post-ercp bleeding and change in pre- and post- procedural pain scores will also be measured. the hypothesis is that iv ibuprofen administered at the time of ercp will decrease rates of post-ercp pancreatitis in pediatric patients.


Eligibility criteria:
inclusion criteria: * age\<=18 years * undergoing ercp (defined as cannulation of the major or minor papilla) for any indication exclusion criteria: * age\>18 * pancreatitis within the 72 hours preceding ercp * allergy or hypersensitivity to aspirin or nsaid medications * pregnancy or breastfeeding mother * cr \>1.4 * gastrointestinal hemorrhage in preceding 72 hours * heart disease reliant upon a patient ductus arteriosis * history of sickle cell disease

Keywords: post-ercp pancreatitis pediatric ibuprofen
crossover study to evaluate the efficacy, safety and tolerability of different doses of indacaterol in patients with persistent asthma

Conditions: Asthma

Summary: the purpose of this study is to determine the efficacy of indacaterol 55µg once daily (and 27.5 µg twice) in qva149 compared to 75 µg indacaterol monotherapy.


Eligibility criteria:
inclusion criteria: * asthma for at least 6 months, using inhaled corticosteroid for at least one month, foreced breath test less than below the normal value of the general population, -show an immediate improvement in breathing when given albuterol exclusion criteria: * patients who have smoked in the past 6 months or are currently smoking, including those who smoked more than a pack of cigarettes a day for at least 10 years, -patients who have a history of life-threatening asthma, -patients who have had an astham attack, in the last 6 weeks, requiring use of systemic steroids, hospitalization, or er visit, -patients who have had a respiratory tract infection or worsening asthma between screening or run-in periods, patients requring use of other asthma-related drugs during the trial, other protocol-defined inclusion/exclusion may apply

Keywords: wheezing, short of breath, laba, inhaler