Kornimate/medical-research-clean huggingface dataset:
community based study on occupational asthma

Conditions: Asthma; Lung Diseases

Summary: to examine the occupations, industries and exposures in the work-place which were associated with a high risk for asthma and other adverse respiratory health effects, with particular emphasis on specific exposures of predominantly female occupations (irritants, detergents and other asthmagens), and of other high risk major occupations which had not been adequately examined.

background: respiratory diseases are strongly related with exposure in the workplace. a considerable proportion of adult onset asthma is associated with these exposures. the importance of occupational risk factors for asthma has been underestimated, particularly among women. the occupational asthma study (ecrhs-oa) forms part of a wider international multicentre survey on respiratory health (european community respiratory health survey-ecrhs). the first phase of the ecrhs was conducted in 1991/92 and examined risk factors for asthma and atopy in subjects aged 20-44 years. the study updated (ecrhs-ii), following-up approximately 17,000 young adults from 12 countries (australia, belgium, france, germany, iceland, italy, norway, spain, sweden, switzerland, uk and usa). the study provided valid and precise estimates on the importance of specific occupations, industries and exposures in relation to asthma incidence and prevalence, similar estimates for other respiratory symptoms and diseases and also for declines in pulmonary function. design narrative: longitudinal, community-based, multicenter study. those subjects who took part in the first occupational asthma study survey were re-contacted in 1999, to determine risk factors for incidence and remission of asthma, other respiratory symptoms, atopy, changes in bronchial responsiveness and lung function. subjects were asked to perform a forced spirometry, methacholine challenge and to provide blood samples for ige testing. a questionnaire administrated by trained interviewers was delivered requesting information on respiratory symptoms and diseases, socio-demographic factors, tobacco smoking, complete occupational history since the last survey, environmental exposures, family history, diet, treatment and use of health services. modular occupational questionnaires were developed for subjects employed as cleaners, homemakers, welders, metal workers, nurses, and subjects exposed to organic dusts in the paper and textile industries. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
user study for enhanced meter feature

Conditions: Diabetes Mellitus

Summary: this enhanced meter feature raises awareness among patients by providing additional information regarding their glycemic control in between healthcare professional visits. this information may facilitate increased dialogue between patient and healthcare professional and can remind patients of the importance of glycemic control. this study will evaluate a user's ability to use the enhanced meter feature.


Eligibility criteria:
inclusion criteria: ic 1. age of subject is 18 years or older ic 2. type i or type ii diabetes inclusive of the following populations: 1. mixed insulin therapies 2. basal insulin therapies 3. bolus insulin therapies 4. csii therapies 5. mdi therapies 6. non-insulin diabetic treatments (oral and injectable) 7. life style (exercise and diet) diabetes management ic 3. able to speak and read english proficiently exclusion criteria ec 1. pregnant ec 2. hct \ 60 ec 3. work for bgm competitor company (including, but not limited to lifescan, roche, abbott) ec 4. homeless ec 5. incarcerated ec 6. institutionalized ec 7. employees or students of the research site, including the principal investigator, directly involved in the conduct of the protocol. ec 8. has any condition that the principal investigator believes may interfere in the subject's participation in the study. ec 9. previous experience using the mystar extra bgms

Keywords: diabetes glucose glucometer
assessment of multi-modality quantitative imaging for evaluation of response of metastatic prostate cancer to therapy

Conditions: Prostate Cancer

Summary: the study is an open label, non-randomized study designed to evaluate the diagnostic performance of spect ct.

the study is an open label, non-randomized study designed to evaluate the diagnostic performance of spect ct. the study will consist of 3 cohorts, and a subset of the patients in cohort c will participate in a test-retest study, where the baseline spect/ct will be repeated. spect ct will be performed in all cohorts. cohort a will evaluate spect ct by comparison to a positron emission tomography (pet) scan using naf. cohort b will evaluate spect ct by comparison to 18f-dcfpyl pet/ct. cohort c will evaluate spect ct by comparison to whole body magnetic resonance imaging (wb-mri). eligible subjects will be enrolled in a non-randomized manner per the treating physician discretion.

Eligibility criteria:
inclusion criteria: males ≥18 years of age. subjects provide signed informed consent and confirm that they are able and willing to comply with all protocol requirements. histologically confirmed adenocarcinoma of the prostate. metastatic castration-resistant prostate cancer (mcrpc) with bone metastases as manifested by one or more lesions on bone scan. documented castrate level of serum testosterone (≤50 ng/dl). documented progressive mcrpc based on at least one of the following criteria: 1. psa progression defined as 25% increase over baseline value or nadir. 2. radiographic progression for soft tissue lesions as per response evaluation criteria in solid tumors (recist 1.1), and/ or radiographic progression for bone lesions as determined by radionuclide bone scan using the consensus guidelines of the pcwg3 criteria. planning to receive first line novel hormonal therapy with abiraterone or enzalutamide for the first time for mcrpc within 4 weeks of documented progression. baseline scans will be obtained prior to starting new therapy. exclusion criteria: subjects who are unable to give valid informed consent subjects who are unwilling or unable to undergo an spect, pet or mr exam, including subjects with contra-indications to mr exams. subjects with prior enzalutamide and abiraterone for mcrpc subjects with prior taxane chemotherapy for mcrpc subjects administered any radioisotope within five physical half-lives or any iv x-ray contrast medium within 24 hours or any high density oral contrast medium (oral water contrast is acceptable) within 5 days prior to study drug injection. subjects with any medical condition or other circumstances that, in the opinion of the investigator, compromise obtaining reliable data, achieving study objectives, or completion. patients with a history reaction to gadolinium contrast agent. for cohort c, patients with renal failure (egfr \< 60ml/min/1.73m2) or patients on dialysis.

Keywords: j1835 spect ct psma 18f-dcfpyl pet/ct wb-mri naf
acute phase proteins as early markers in sepsis

Conditions: Sepsis

Summary: monitoring of different serumproteins after severe trauma and during trauma-induced sepsis. * trial with surgical intervention


Eligibility criteria:
inclusion criteria: * patients with severe trauma (iss score \> 16), both genders, patients on icu exclusion criteria: * moribund patients (ph \ 15mmol, basedeficit \> 15meq/l, severe heart or liver injuries, gcs never over 5 after trauma) * severe head injuries (ais head \>4) * patient with severe infectious diseases, or diseases which severely affect the immune system (diabetes, alkohol or nicotine abuse) * non-german speaking patients
cardiovascular comorbidity in children with chronic kidney disease

Conditions: Childhood Chronic Kidney Disease

Summary: this 3-year study will systematically evaluate the prevalence, clinical symptoms, and progression of cv and kidney disease and assess the impact of potential genetic, pharmacological, behavior, and environmental risk factors in a prospective cohort with a sample size of 125 aged 3-18 years children with stage g1-g4 chronic kidney disease (ckd). measurements of morphological (e.g., lvmi \& cimt) and functional characteristics (e.g., fmd \& pwv) of the cardiovascular system and 24hr abpm profile will serve as surrogate end points for cv comorbidity in this study. possible associations of these end points with multiple molecular (adma \& urine exosome mirna), perceived value and behavior (eq-5d-y), pharmacological (nhird and cgrd), and environmental risk factors (patient and family survey) will be explored.

taiwan has the highest incidence and prevalence rates of end-stage renal disease all over the world. chronic kidney disease (ckd) becomes a global public health burden, which can begin in earliest childhood. ckd in childhood differs from that in adults. congenital anomalies of the kidney and urinary tract (cakut) is the leading cause of childhood ckd. children with ckd due to cakut have the highest risk of having a genomic imbalance. thus, early identification of genotype-phenotype correlations to develop novel therapeutic approaches might reduce the heavy burden of ckd for the future of taiwan. study design: 1. a 3-year prospective cohort study. 2. sample size: 125 children and adolescents with stage g1-g4 ckd, age 3 to 18 yr, and 30 controls. 4. measurement: measurements of morphological (e.g., lvmi \& cimt) and functional characteristics (e.g., fmd \& pwv) of the cardiovascular system and 24hr abpm profile will serve as surrogate end points for cv comorbidity in this study. possible associations of these end points with multiple molecular (adma \& urine exosome mirna), perceived value and behavior (eq-5d-y), pharmacological (nhird and cgrd), and environmental risk factors (patient and family survey) will be explored.

Eligibility criteria:
inclusion criteria: * children and adolescents with stage g1-g4 ckd exclusion criteria: * current pregnancy * inability to complete major data collection * kidney transplant * cancer

Keywords: arterial stiffness, children, chronic kidney disease, hypertension, microrna
transcranial direct current stimulation for post-stroke aphasia

Conditions: Stroke

Summary: this is a randomized, crossover design trial that will compare how anodal transcranial direct current stimulation (tdcs) versus sham tdcs administered during multiple sessions of scripting therapy affects the acquisition and retention of trained scripts.


Eligibility criteria:
inclusion criteria: 1. age over 21 years 2. ischemic left hemispheric stroke verified by imaging (ct or mri) greater than 6 months ago 3. residual non-fluent or anomic aphasia, with western aphasia battery-revised aphasia quotient score \<60 4. fluent english speaker prior to stroke 5. right-handed prior to stroke 6. ability to give informed consent and understand the tasks involved. exclusion criteria: 1. history of recurrent stroke, either ischemic or hemorrhagic, in the left middle cerebral artery territory 2. imaging unavailable 3. large middle cerebral artery infarct involving entire inferior division (temporo-parietal) territory 4. history of dementia prior to the stroke 5. history of seizure, prior electroconvulsive therapy, deep brain stimulators, or brain surgery 6. social and/or personal circumstances that interfere with ability to return for therapy and assessment sessions.
epstein-barr virus as a possible cause for chronic fatigue syndrome

Conditions: Chronic Fatigue Syndrome

Summary: the purpose of this study is to understand what causes a continuing fatigue for a long time with a number of symptoms occurring at the same time (chronic fatigue syndrome-cfs). epstein barr virus is among the group of viruses that have been associated with a continuing fatigue for a long time with a number of symptoms occurring at the same time, but the cause is still unknown.

epstein-barr virus (ebv) is the etiological agent for heterophile positive infectious mononucleosis (im). it is also an oncogenic herpes virus associated with african burkitt's lymphoma (bl),nasopharyngeal carcinoma (npc) and aids-associated b-cell lymphomas. ebv is also among a group of viruses that have been associated with chronic fatigue syndrome (cfs), although the etiology of cfs still remains unknown.findings may lead to hypothesize that ebv enzymes, such as the dutpase, have the capacity to induce immune dysregulation of the t-cell and nk cell responses and that this immune dysregulation produces immunopathology that results in the symptoms that we call cfs.

Eligibility criteria:
inclusion criteria: * healthy adults for controls. * adults with chronic fatigue syndrome. exclusion criteria: * individuals with significant medical illness in reference to immunosuppressant drug. note: we recruit participants in the mississippi area who could come in our site to provide blood draw.

Keywords: chronic fatigue syndrome epstein-barr virus
impact of the covid-19 on rsv epidemic in the metropolis of lyon

Conditions: Rhinovirus; RSV Infection in Children Less Than 5 Years of Age

Summary: the magnitude of seasonal rsv epidemics brings each year new logistical challenges for the hospitalization of young infants with bronchiolitis that overwhelm hospital capacities and lead to specific winter plans with deprogramming and mobilization of human and logistical resources. the covid-19 pandemic has changed the way winter epidemics are presented. for example, the seasonal rsv epidemic was shifted by several months in lyon, with an impression of a lower incidence of hospitalized cases, with a population of older children and with fewer signs of clinical severity. this is largely attributable to the widespread use of barrier gestures and social distancing measures, known as "non-pharmacological interventions" or npi. given the magnitude of the reduction of the rsv epidemic, it is legitimate to analyze the benefits of npis to draw lessons for maintaining preventive measures around rsv-vulnerable populations; moreover, new preventive pharmacological interventions are soon to be marketed, whether they are particularly refined and long half-life anti-rsv monoclonal antibodies, rsv vaccines for mothers or for newborns and infants. in this perspective, it is crucial to properly define the populations at risk of severe disease to establish a legitimate hierarchy in the implementation of different preventive strategies. the study of the rsv epidemic is a high potential model because of the convergence of epidemiological, virological, and pharmacological knowledge. however, the study of the impact of the pandemic on the epidemiology of rhinovirus also seems promising because, for reasons unknown to date, it seems that the pandemic did not have the same reducing impact on the rhinovirus epidemic; in the latter case, the interest is to confirm the resistance of this virus and to look for more fundamental explanations, for example, on viral interactions. on a previous study (see ntc 04944160), 519 infants were recruited in the pre-covid-19 season population, and 277 infants were recruited in the first per-covid-19 season population.


Eligibility criteria:
inclusion criteria: * child hospitalized at " hôpital femme mère enfant ", lyon, france * positive rsv-pcr exclusion criteria: * parent's refusal to participate

Keywords: rsv epidemic covid-19-rsv interaction non-pharmacological-interventions bronchiolitis asthma pneumonia
comparison of different pain rating scales in patients with symptomatic teeth

Conditions: Pain; Dental Pain

Summary: patients with symptomatic teeth who applied endodontic clinic between april 2019 and december 2019 for root canal treatment were enrolled in this study. all patients were asked to fill four different rating scales: numerical rating scale, visual analogue scale, color analogue scale and faces rating scale for their relevant tooth which is symptomatic and need of root canal treatment. the four scales were then compared statistically.

50 patients who applied endodontic clinic between april 2019 and december 2019 and had symptomatic teeth which were in need of root canal treatment were enrolled for this study. study detail were explained to all patients and they were then kindly asked to signed a consent form. all patients diagnose, age, gender, tooth number were recorded. patients were then asked to fill four different pain rating scale in an electronic pain rating scale program. numerical rating scale (nrs) was a scale between "0" and "10", with "0" indicating no pain while "10" indicating worst pain possible. visual analogue scale (vas) was a straight line of 10 cm with one end of the line indicated no pain whilst the other end indicated worst pain possible. color analogue scale (cas) was the same length of straight line as in vas with a color change towards to worst pain possible end. faces rating scale (frs) consisted of six different faces indicating the level of pain with the first face indicated no pain while the last face indicated worst pain possible. after the patients marked their pain intensity levels in all four scales the results were statistically analyzed to compared the accuracy of four scales with vas being the golden standard.

Eligibility criteria:
inclusion criteria: * symptomatic teeth which is in need of root canal treatment exclusion criteria: * systemic diseases * age \ 80 * being able to understand and accept the study protocol with a written consent form.

Keywords: numerical rating scale visual analogue scale color analogue scale faces rating scale pain intensity
epidemiological study in thai participants with hypertension

Conditions: Hypertension

Summary: the purpose of this study is to evaluate blood pressure (bp) goal attainment in adult participants with essential hypertension.

this study has been designed as a non-interventional, observational study to obtain information on hypertension treatment regimens and how well hypertension is controlled in thai patients in real-life settings. antihypertensive medications prescribed in this study will be at the discretion of the investigator and the standard of care practice at the particular study site. the study will enroll approximately 2000 patients. participants with well-controlled hypertension on their current antihypertensive therapy will participate in the study for only 1 visit. participants with history of hypertension who are uncontrolled on the current antihypertensive medications or participants with newly diagnosed hypertension (diagnosed within the past 4 weeks and uncontrolled on antihypertensive therapy) will be observed over the course of 12-16 weeks. these participants will make 3 visits to the study site. this multi-centre trial will be conducted in thailand.

Eligibility criteria:
inclusion criteria: 1. ability to provide written informed consent 2. age above 18 years. 3. participants with essential hypertension as per european society of hypertension/european society of cardiology (esh/esc) criteria in general, target blood pressure (bp), systolic blood pressure (sbp) \ 300 mg/day or 200 microgram/min), target bp, sbp \<130 and dbp \<90 mmhg). essential hypertension will be defined based on the criteria established by the esh/esc 2013 criteria: * grade 1 essential hypertension - systolic blood pressure (sbp) 140 - 159 mmhg and/or diastolic blood pressure (dbp) 90-99 mmhg with no identifiable cause * grade 2 essential hypertension - sbp 160 - 179 mmhg and/or dbp 100 - 109 mmhg with no identifiable cause * grade 3 essential hypertension-sbp ≥ 180 and/or dbp ≥ 110 mmhg with no identifiable cause. exclusion criteria: 1. female participants who are breastfeeding or pregnant or who are intending to become pregnant. 2. has known or suspected secondary hypertension. 3. is currently enrolled in or has not yet completed at least 30 days since ending an investigational product or device study or is receiving other investigational agents.

Keywords: drug therapy
reconstructions of chest wall defects: a retrospective study

Conditions: Chest Wall Deformity

Summary: patients requiring thoracic reconstruction often suffer from numerous comorbidities, such as obesity, diabetes, atherosclerosis and cardiovascular diseases, respiratory diseases. the clinical picture of these patients must be carefully stabilized in the preoperative period since the listed diseases are associated with a poor reconstructive outcome. furthermore, it is necessary to preoperatively determine the spirometric characteristics in cases where the intervention may alter the respiratory dynamics to evaluate the patient's ability to tolerate the procedure. the primary objective of the study is to identify the best diagnostic-therapeutic approach in cases of complex chest wall defects, retrospectively evaluating the outcomes and therapeutic choices implemented, through a reassessment of the interventions performed and the clinical progress of patients undergoing complex thoracic and sternal reconstruction interventions managed in a multidisciplinary and non-multidisciplinary manner

currently there are no univocal universally accepted guidelines regarding the intervention to be performed in case of complex chest wall reconstructions or for the treatment of sternal wound dehiscences. different options are described, both for the demolition phase and for the reconstructive phase in the thoracic and sternal area. the choice of one method rather than the other is currently largely based on the experience and preference of the specific working group. the importance of the study lies in the attempt to analyze the choices made in the diagnostic and therapeutic phase (demolitive, reconstructive, pharmacological) on patients treated at the aou sant'orsola (now irccs) in past years. the secondary objective of the study is to improve the multidisciplinary management of patients who are candidates for complex chest reconstructions. in particular, the drafting of a multidisciplinary therapeutic protocol that uses algorithms to optimize the choice of surgical procedure and medical therapy in terms of resolution of the problem, hospitalization times, and patient quality of life.

Eligibility criteria:
inclusion criteria: * all patients undergoing sternal or thoracic reconstruction in collaboration or not with the reconstructive plastic surgery unit * obtaining informed consent exclusion criteria: -