Kornimate/medical-research-clean huggingface dataset:
hstnt in stable coronary artery disease

Conditions: Coronary Artery Disease

Summary: coronary artery disease (cad) is one of the leading causes of morbidity and mortality worldwide. life threatening manifestations such as acute myocardial infarction (ami) and sudden cardiac death are the most important causes of death in many countries. cardiac troponin is a biomarker with a high specificity for cardiac necrosis and is recommended for diagnosis of acute myocardial infarction by the universal definition of myocardial infarction. since a new generation of high-sensitivity cardiac troponin assays has become commercially available a few years ago, myocardial infarction can be detected earlier and even small amis, that were classified as unstable angina pectoris (uap) with the less sensitive assays, are detectable now. on the other side, more patients with acute or chronic myocardial damage not due to ami are identified now. thereby, the reason for elevated troponin levels should be sought actively, because high troponin levels were associated with adverse outcome - independent of the underlying pathomechanism. the reasons for troponin elevations in patients with stable cad are not clear yet. associations with extensive atherosclerosis, carotid lesions and complex coronary plaques in coronary ct scans were reported. therefore, patients with elevated troponin levels represent a risk population and might profit from intensified secondary prevention. in this context, ticagrelor might be part of a prevention strategy as currently tested in the pegasus trial. we plan to conduct a single-centre pilot study in a cohort with clinically stable patients of our outpatient clinic, because data regarding prevalence, causes and prognosis of elevated troponin values in unselected cohorts is sparse. therefore, all patients (n=910) that presented to our outpatient clinic 12 months after introduction of the high-sensitivity troponin t assay (june 2009) and were free of complaints or presented with uap are being enrolled. all patients are characterized by demographic, laboratory and clinical characteristics (including medication) and all available imaging data (exercise-ecg, echocardiography, stress-echocardiography, computed tomography, cardiac mri and coronary angiography) in order to compare baseline characteristics of troponin positive and troponin negative patients. in addition, the framingham- and procam-score representing established calculators of long-term risk prediction are calculated. prognostic endpoints are defined as severe cardiovascular events and progress of the initially diagnosed disease. those endpoints are associated with the initial hs-ctnt value and serial changes.


Eligibility criteria:
inclusion criteria: * patients of outpatient clinic presenting 12 months after introduction of the hs-tnt test in june 2009 exclusion criteria: * none
nutrition status of adults with pku before and during treatment with pegvaliase

Conditions: Phenylketonurias

Summary: conduct a prospective, longitudinal study to evaluate nutritional status in adults with phenylketonuria (pku) before and during treatment with pegvaliase (palynziq™).

the investigators will compare intra-subject change in adults with pku who follow a protein-restricted diet (protein intake less than the rda for protein based on weight (0.8 g/kg/day) with or without a pku medical food) within 90 days of starting pegvaliase (baseline) and 9 and 15 months later. the investigators will collect laboratory measures of nutrition status, anthropometrics, dual-energy x-ray absorptiometry (dxa) to measure body composition and bone mineral density (bmd), and indirect calorimetry to measure resting energy expenditure (ree). in addition, three-day food records will be obtained to assess protein intake and overall diet quality.

Eligibility criteria:
inclusion criteria: * diagnosis of phenylketonuria * aged 18-65 years * following a protein-restricted diet with or without medical food within the last 30 days * routine natural protein intake from food is less than the rda for protein based on weight (0.8 g/kg/day). * if not consuming animal proteins, recommended protein intake is 115% rda due to lower bioavailability of plant proteins. * within ±90 days of starting treatment with pegvaliase at time of study enrollment exclusion criteria: * unable to consent to study * under age 18 or over age 65 years * routine natural protein intake is greater than the rda for protein (0.8 g/kg/d) within the last 30 days. * females who are currently pregnant or lactating
effect of elastic bandage on balance in chronic ankle instability

Conditions: Ankle Sprain

Summary: purpose: to report the immediate and prolonged (one week) effects of elastic bandage on balance control in subjects with chronic ankle instability. material and methods: twenty-eight individuals successfully completed the study protocol, of whom 14 were randomly assigned to the elastic bandage group (7 men, 7 women) and 14 were assigned to the non-standardized tape group ( 9 men, 5 women). to objectively measure postural sway we used computerized dynamic posturography with sensory organization test and unilateral stance test. we analyzed the following sensory organization test parameters: the composite sensory organization test score, the composite sensory organization test strategy and the sensory organization test condition 2 and its strategy. in addition, we studied the centre of gravity sway velocity with open eyes and close eyes during the us test.


Eligibility criteria:
inclusion criteria: subjects with chronic ankle instability exclusion criteria: neurologic disease vestibular disease

Keywords: adhesive elastic bandaging balance posturography
platelet activity in vascular surgery for thrombosis and bleeding

Conditions: Peripheral Vascular Disease; Peripheral Artery Disease; Carotid Stenosis; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Amputation, Wound; Embolism and Thrombosis; Aortic Aneurysm

Summary: the proposed pivotal study will examine a panel of platelet/coagulation activity markers during the perioperative period. the goal is to develop a clinically useful assessment of platelet/coagulation activity for risk stratification that may ultimately serve as a target for therapeutic intervention. this study will enroll 200 patients with peripheral artery disease undergoing vascular surgery. pivotal is funded by american heart association and is scheduled to begin enrollment in july 2013 for approximately two years.

to describe platelet activity among pad subjects undergoing vascular surgery. to determine whether preoperative platelet activity measurements are independently associated with perioperative cardiovascular events. to identify demographic, clinical, and surgical factors associated with postoperative platelet activity measurements in patients with established pad.

Eligibility criteria:
inclusion criteria: * subjects undergoing non emergent vascular surgery * use of aspirin within 48 hours prior to surgery * age \> 21 years of age * able and willing to provide written informed consent for the study exclusion criteria: * use of any anticoagulant (coumadin, heparin) within 24 hours to surgery * use of any nonsteroidal antiinflammatory drug (nsaid) (such as ibuprofen, naproxen, etc.) within 72 hours * thrombocytopenia (platelet count\ 500), * anemia (hemoglobin\<9), * severe kidney disease (crcl\<30ml/min), * any known hemorrhagic diathesis.

Keywords: peripheral artery disease endarterectomy (carotid) aortic aneurysm, abdominal aortic aneurysm, thoracic amputation platelet activity thrombin transcriptomics
orthodontic screening in public healthcare

Conditions: Malocclusion; Compliance, Patient

Summary: the aim of the study is to examine orthodontic screening practises in public health care.

the study aims to assess repeatability of malocclusion evaluation in orthodontic treatment need screening in a publicly funded clinic. the objective treatment need is compared with subjective need for orthodontic treatment.

Eligibility criteria:
inclusion criteria: * residence in the wellbeing services county catchment area * willingness to participate in the study exclusion criteria: * age under 6 years or over 16 years * insufficient language skills to be able to understand the questionnaire
a 6-week study to determine the safety and effect of an investigational drug on adults with type 2 diabetes mellitus taking metformin

Conditions: Type 2 Diabetes Mellitus

Summary: a phase 2a study to evaluate the effects of an investigational compound administered at 200 mg, twice daily (bid), for 6 weeks in adult subjects with type 2 diabetes mellitus (t2dm) on metformin background therapy.


Eligibility criteria:
inclusion criteria: * patients with type 2 diabetes mellitus and treated with metformin at a dose greater than or equal to 1000 mg for at least 3 months * hemoglobin a1c of 7-10% at screening. * body mass index of at least 25 kg/m2. exclusion criteria: * compliant with study drug administration during the run-in period and throughout the trial. * patients with fasting triglycerides greater than 500 mg/dl at screening. * history of certain diabetic complications or cardiac problems.
comparison between negative pressure wound therapy and conventional wound dressings before and after split-thickness skin grafting in diabetic foot wounds

Conditions: Negative-Pressure Wound Therapy; Diabetic Foot

Summary: the aim of this thesis is to compare the efficacy of vacuum assisted closure device versus conventional dressing before and after split thickness skin grafting in diabetic foot wounds.

negative pressure wound therapy is a new noninvasive technique for treating open wounds. it works by removing fluid from the wound bed, reducing edema, and encouraging the growth and perfusion of new granulation tissue. vacuum-assisted closure device (vac) helps to remove fluid from open wounds through a sealed dressing and tubing which is connected to a collection container. vacuum-assisted closure (vac) can provide stable and persistent negative pressure, and there are several modes to choose from. vac has played an important role in helping to close wounds, controlling infection, promoting angiogenesis, increasing blood flow, and promoting granulation tissue growth in wounds. it is now widely applied in all kinds of acute, chronic, and special wounds with good therapeutic results. however, there is a need to pay attention to contraindications and complications of vac when it is used, avoiding secondary damage due to improper treatment.

Eligibility criteria:
inclusion criteria: * age group 20-75 years. * patients with diabetic foot wounds who are scheduled for skin grafting. exclusion criteria: * age \ 75 years. * an obvious septicemia. * foot osteomyelitis. * ulcer resulting from venous insufficiency. * features of malignant ulcer. * patients being treated with corticosteroids, immunosuppressive drugs. * any other serious pre-existing cardiovascular, pulmonary or immunological disease.
characteristic study on chinese patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: compared with ms in white populations, in people of china descent multiple sclerosis (ms)is characterized by lower prevalence, more frequent and severe involvement of the visual system at onset and during the entire clinical course, more common occurrence of optic and spinal involvement, relatively rapid progression and less common occurrence of a progressive course. data are not available for mainland china that are focused on characteristic studies of ms. in this study, the investigators sought to explore the characteristics of ms among chinese in china, by conducting a study on genetics, pathogenesis, pathology, neuroimaging characteristics, and so on. based on these data, the investigators try to explore the difference in neuromyelitis optical (nmo) and ms and provide clinical data for treatment guidelines for nno and ms.


Eligibility criteria:
inclusion criteria: * criteria for neuromyelitis optical * optic neuritis * acute myelitis * at least two of three supportive criteria: * contiguous spinal cord mri lesion extending over \>= 3 vertebral segments * brain mri not meeting diagnostic criteria for multiple sclerosis * nmo-igg seropositive status * criteria for multiple sclerosis: * two or more attacks; objective clinical evidence of two or more lesions, or * two or more attacks; objective clinical evidence of one lesion, dissemination in space, demonstrated by: mri or two or more mri-detected lesions consistent with ms plus positive csf or wait further clinical attack implicating a different site, or * one attack; objective clinical evidence of two or more lesions, dissemination in time, demonstrated by: mri or second clinical attack, or * one attack; objective clinical evidence of one lesion (monosymptomatic presentation; clinically isolated syndrome), dissemination in space, demonstrated by: mri or two or more mri-detected lesions consistent with ms plus positive csf and dissemination in time, demonstrated by: mri or second clinical attack, or * insidious neurological progression suggestive of ms, one year of disease progression (retrospectively or prospectively determined) and two of the following: 1. positive brain mri (nine t2 lesions or four or more t2 lesions with positive vep) 2. positive spinal cord mri (two focal t2 lesions) 3. positive csf exclusion criteria: * \> 65 yrs old * heavy damage of heart, lung, liver, renal function * late neuromyelitis optical or edss \> 6.0 * serious hypertension and diabetes * serious mental disorders and depression * allergic to drug: atorvastatin, β-interferon, epo, immunoglobulin

Keywords: multiple sclerosis,genetics,pathogenesis,pathology,therapy
study of reserves after traumatic brain injury

Conditions: Traumatic Brain Injury

Summary: it is hypothesized that the long-term results of rehabilitation and subsequent aging after brain trauma depend on brain's premorbid anatomical (structural) and functional (cognitive, emotional) reserves. the purpose of this study are: 1. to determine whether such reserves exist. 2. to study their convergent and discriminant validity. 3. to study their characteristics.


Eligibility criteria:
inclusion criteria: * moderate-severe traumatic brain injury according to at least 1 the following: * duration of loss of consciousness (loc) - more then 1/2 hour * glasgow coma scale (gcs) - less then 13 * post traumatic amnesia (pta) - more then 24 hours. * at least 1 year after the injury. exclusion criteria: * mild traumatic brain injury * the present state of post traumatic amnesia * dementia * the age less than 18 years on the moment of injury * less than 1 year since the injury * incapacity of the patient to cooperate in the study (incapacity of any source including physical, mental, and language problems) * premorbid diagnosis of mental retardation

Keywords: traumatic brain injury long-term outcome brain reserves cognitive reserves emotional reserves patients 1 year or more after moderate or severe traumatic brain injury
testing mtbi in athletes

Conditions: Mild Traumatic Brain Injury; Brain Concussion

Summary: this study will assess the effectiveness of a portable goggle system in the diagnosis of mild traumatic brain injury (mtbi) in athletes.

the purpose of this research study is to assess oculomotor, vestibular and reaction time responses in mild traumatic brain injury (mtbi) athletes, as well as healthy individuals. these measurements will be recorded using a portable goggle system (ipas). the goal is to determine whether this ipas goggle system is effective at diagnosing mtbi. a secondary goal is to determine whether this ipas goggle system is effective at ruling out the diagnosis of mtbi in athletes and non-athletes that do not have the condition. the ipas is a portable 3d head mounted display. the ipas goggles are programmed with a series of tests that track eye motions in response to a target. this device has been determined to be a non-significant risk to study participants. there are three groups of interest in this study: athletes who suffer an mtbi, athletes who do have an mtbi, and healthy non-athletes.

Eligibility criteria:
inclusion criteria: * males and females from 18 - 40 years of age who participate in intercollegiate athletics at the university of miami to include all levels of sports whether ncaa or club. initial recruitment will include high intensity sports alone (these include but are not limited to football, men's and women's soccer, men's and women's basketball, men's baseball and women's softball, and club sports to include men's and women's lacrosse, hockey, rugby, and field hockey). exclusion criteria: * history of brain injury resulting from a penetrating wound to the head. * presence of severe aphasia * history of diagnosed neuropsychiatric disorders (e.g. hypochondriasis, major depression, schizophrenia * documented neurodegenerative disorders * pregnancy, \[female candidates will be asked if they are pregnant\] * prior disorders of hearing and balance including: 1. meniere's disease 2. multiple sclerosis 3. vestibular neuritis 4. vestibular schwannoma 5. sudden sensorineural hearing loss * cerebrovascular disorders * history of ear operation other than myringotomy tube in the past * systemic disorders: e.g. chronic renal failure, cirrhosis of the liver, etc.
efficacy of ericksonian hypnosis in the management of chronic pain related to parkinson's disease

Conditions: Parkinson Disease; Chronic Pain

Summary: this study evaluates the efficacity of erickson hypnosis in the treatment of chronic pain in patients with parkinson's disease. half of participants will follow a 2-month erickson hypnosis protocole, while the other half will benefit from the usual care.

a large proportion of patients with parkinson's disease suffer of chronic pain directly related to the disease. the management of painful symptoms is difficult and currently, there is no commonly admitted guidelines. several studies have shown the efficacy of erickson hypnosis to reduce the perception of chronic pain in different conditions. this efficacy has never been tested in parkinson's disease. the objective of this study is to assess the efficacy of erickson hypnosis protocol, compared to usual care, for the management of parkinson's disease-related chronic pain. the study team assume that erickson hypnosis will be more efficient than usual care to reduce perceived chronic pain. they also assume that regular practice of autohypnosis will contribute to long-term efficacy.

Eligibility criteria:
inclusion criteria: * men or women * 18 to 80 years old * idiopathic parkinson's disease * without neurological co-morbidity * suffering from chronic pain (for at least 3 months), related to parkinson's disease * having a pain intensity of at least 30 mm on the vas (average intensity over the previous week) for parkinson's disease-related pain * antiparkinsonian, analgesic and psychotropic treatments stable for 1-month * having a health insurance * signed informed consent form exclusion criteria: * patient with a neurological condition other than parkinson's disease or with an atypical parkinson's syndrome * early untreated patient * patient with acute intercurrent pain * patient whose pain is mainly attributable to another pathology (rheumatoid arthritis, spondyloarthritis ankylosing, diabetic neuropathy, cancer, etc.) * patient with cognitive impairment objectified by a score at the montreal cognitive assessment (moca) \<24 * patient with hallucinations and/or psychosis (mds-updrs 1.2\> 1) * patient with a apathy (mds-updrs 1.5\> 1) * patient with disabling dyskinesia (mds-updrs) 4.1 and 4.2\> 1) * patient under the protection of adults * pregnant or lactating woman

Keywords: no-motor symptoms pain perception quality of life hypnosis auto-hypnosis
effect of methylprednisolone on glucose homeostasis in patients undergoing total hip- and knee-arthroplasty

Conditions: Osteoarthrosis

Summary: this study evaluates the pathophysiological effects of a single dose of methylprednisolone administered prior to total hip- and knee-arthroplasty surgery. the investigators examine the effect on blood glucose homeostasis. half of participants will receive intravenous solu-medrol 125 mg, while the other half will receive placebo. the investigators hypothesize that the glucose homeostasis remains equally stable in the group receiving methylprednisolone as in the group receiving placebo.

the anti-inflammatory effects of glucocorticoids are well known. the beneficial effects on postoperative pain, postoperative nausea and vomiting are well-documented. glucocorticoid might change the glucose metabolism as it induces insulin-resistance. glucocorticoids are known to reduce the insulin-mediated glucose uptake by reducing the muscle glycogen synthase activity. the effect of a single high dose of glucocorticoid is poorly described in the literature, and therefore calls for further investigation. this study is embedded in a primary study registrated as: nct02319343 for further details please view the eudract registration: eudract nr.: 2014-003395-23

Eligibility criteria:
inclusion criteria: * osteoarthrosis * undergoing total unilateral hip- or knee arthroplasty surgery * speak and understand danish * have given informed consent exclusion criteria: * revision or bilateral hip- or knee-arthroplasty surgery * general anaesthesia * allergy or intolerance towards methylprednisolone * local or systemic infection * permanent systemic treatment with steroids within 30 days preoperatively * insulin-dependent diabetes * active treatment of ulcer within 3 months preoperatively * cancer disease * autoimmune disease incl. rheumatoid arthritis * pregnant or breast feeding women * menopause \<1 year

Keywords: glucocorticoid glucose homeostasis knee arthroplasty, total hip arthroplasty, total