Kornimate/medical-research-clean huggingface dataset:
weaning preterm infants at 1500 grams from incubators

Conditions: Preterm Infants

Summary: background: the weight at which infants are weaned from incubators varies among neonatal units. objective: to determine the effect on weight gain, temperature stability and resting energy expenditure (ree) of weaning infants at body weight of 1500 g versus 1600 g. design/methods: infants will be randomized to incubator weaning at the weight of 1500 g or 1600 g. preterm infants 1500 g birth weight, fully enterally fed, and without supplemental oxygen, at the postnatal age of 2 weeks will be included. infants will be weaned to a warming bassinet (babytherm 8000, dräger) set to keep a mattress temperature of 37°c while decreasing it gradually to room temperature. failure to wean is defined as core body temperature of \< 36.1°c. data collection included skin and rectal temperature obtained before weaning, and at 1/2, 1, 2, 6, 24, and 48 hours after weaning, weekly weight gain (g/kg/d). ree (kcal/kg/24h) will be measured by indirect calorimetry (deltatrac ii, finland) before and 24 hours after weaning.

eligible infants will be randomized by computer generated random numbers, to either the study group weaned at 1500 g or the control group weaned at 1600 g. both groups will be weaned to a warming bassinet (babytherm 8000, drager). the babytherm 8000 wb is an open care infant warming system with a warmed gel mattress with temperature control . the system is set to keep the mattress temperature of 37 degrees celsius while decreasing it gradually to 32 0c and shutting the system off. on transfer to the babytherm infants are dressed with a hat and two vests. only after the infant maintained a normal body temperature under these conditions he could be transferred to an open bassinet. failure to wean was defined as core body temperature of \<36.10c. data collection included skin and rectal temperature obtained before weaning, and at 1/2, 1, 2, 6, 24, and 48 hours after weaning, daily and weekly weight gain (g/kg/d). resting energy expenditure- ree (kcal/kg/24h) is measured by indirect calorimetry (deltatrac ii, finland) before and 24 hours after weaning to the warming bassinet. data collection included: pr temperature after 30 min, 60 min, 2 hours, 6 hours, 24 hours, after which temperatures were taken 4-hourly until 48 hours (degrees c), skin (axillary) temperature (degrees c), after 30 min, 60 min, 2 hours, 6 hours, and than again every 4 hours until 48 hours. ree (kcal/kg/24h)rate of hypothermia requiring return to the incubator, weight gain after 24 hours of weaning and over 1 week.( g/kg/d),time to discharge ( days).

Eligibility criteria:
inclusion criteria: * stable preterm infants weighing ≤1500 g * fully enterally fed, and without supplemental oxygen * steroid or antibiotics treatment * at the postnatal age of ≥ 2 weeks were included * infants \< than 2 weeks of age exclusion criteria: * ventilated infants or those requiring oxygen supplementation * parenteral nutrition * antibiotic treatment or steroids treatment were excluded

Keywords: energy expenditure hypothermia body temperature weaning preterm infants
peng block in comparison with ficb for hip reconstruction in children

Conditions: Perioperative Analgesia; Hip Dislocation, Developmental

Summary: the goal of this clinical trial is to test the hypothesis that performing a pericapsular nerve group (peng) block allows for more effective analgesia in the perioperative period during reconstructive surgery on the hip in children with cerebral palsy and spina bifida compared with fascia illiaca compartment block (ficb).

the main question it aims to answer is: is the peng block an effective and safe method of pain relief for hip surgery in children? participants will be randomized into two equal groups. the group who underwent us - guided peng block, and the group who underwent us - guided ficb . in both groups we used 0.5% ropivacaine. the same postoperative analgesia regimen was applied by intravenous acetaminophen , oral ibuprofen . in case of ineffectiveness of the prescribed drugs, promedol was used intramuscularly. the postoperative consumption of promedol, time to first rescue analgesia, numerical pain score (nrs) (for children from 7 years old), flacc score, measurements of a.n.i. monitor mdms and the side effects will be recorded

Eligibility criteria:
inclusion criteria: * reconstructive surgery on the hip joint * children with cerebral palsy * children with spina bifida * age 3 - 18 years. exclusion criteria: * contraindications to the use of local anesthetics * contraindications to performing an invasive procedure * asa \> 3

Keywords: anesthesia local nerve block postoperative pain hip dislocation children
comparison of misoprostol and prostaglandin e2 (pge2) gel for induction of labour in premature rupture of membranes at term

Conditions: Premature Rupture of Membranes at Term

Summary: the purpose of this study is to determine whether induction of labor with vaginal misoprostol application will result in fewer cesarean deliveries than vaginal pge2 gel application in women with premature rupture of membranes at term.


Eligibility criteria:
inclusion criteria: * premature rupture of membranes at 37 or more weeks * single live fetus in cephalic presentation exclusion criteria: * women in labour * women with contraindication of induction of labour * women with previous caesarean section or uterine surgery

Keywords: premature rupture of membranes at term induction of labour misoprostol pge2 gel immediate induction with pge2 gel immediate induction with misoprostol
evaluation of a novel pancreaticojejunostomy technique for pancreaticoduodenectomy

Conditions: Pancreatic Fistula

Summary: pancreaticoduodenectomy is a surgical procedure for removing cancer in the pancreas, the bile system or the duodenum that is associated with a high rate of complications. the study wants to investigate whether a new technique to reconstruct the joint between the pancreatic gland and the short bowel can reduce the rate of severe complications after this complex surgical procedure.

pancreaticoduodenectomy is a complex surgical procedure for radically resecting tumors in the pancreatic head, distal bile duct or duodenum. postoperative pancreatic fistula is the main contributor of severe postoperative morbidity after pancreaticoduodenectomy. characteristics of the pancreatic gland like soft pancreatic consistency and small pancreatic main duct predispose for the postoperative fistula development. in high risk patients, the risk of suffering from associated postoperative morbidity is 50 percent which is considered unacceptable high. the aim of the current trial is to investigate whether a new anastomosing technique for the pancreaticojejunostomy can reduce the incidence of associated postoperative morbidity in patients undergoing pancreaticoduodenectomy.

Eligibility criteria:
inclusion criteria: * patients scheduled for elective pancreaticoduodenectomy * pancreatic gland with high risk criteria for associated postoperative morbidity exclusion criteria: * patients do not accept participation * pancreatic gland with intermediate or low risk criteria for associated postoperative morbidity

Keywords: postoperative pancreatic fistula pancreatic texture pancreatic duct diameter pancreatic consistency pancreaticoduodenectomy
psychoeducatıon interventıon postpartum depressıon breastfeedıng

Conditions: Postpartum Depression; Psychoeducation; Breastfeeding; Postpartum Care

Summary: this study was planned to evaluate the effects of psychoeducation intervention for postpartum care on postpartum depression and breastfeeding.

the pregnant women included in the sample were informed about the study and their written informed consent was obtained. six interviews were conducted with the pregnant women, four at one-week intervals before birth, and one on the tenth day and sixth week after birth. these interviews were conducted with the women one-on-one and face-to-face.women in the control group were not given any treatment other than routine care at family health centers. the psychoeducation program was applied to the women in the intervention group in six interviews.

Eligibility criteria:
inclusion criteria: * 20-34. women who are at the gestational age, * over 18 years of age, * planning to breastfeed, * have no visual, * hearing or mental disabilities, * have a healthy fetus on ultrasonography exclusion criteria: * women with depression and other mental illnesses diagnosed by a physician, * those taking medication related to their mental illness, * those who gave birth prematurely, * those with contraindications to breastfeeding and newborns (head and spine anomalies such as anencephaly/spina bifida, having a fetus with brain anomalies such as hydrocephalus/microcephaly, active substance use or hiv diagnosis, etc.), * those who were included in the study in the 3rd trimester but whose birth weight was less than 2500 grams, * those whose babies were taken to the neonatal intensive care unit due to any postpartum complications and those who had premature babies (born before 37 weeks of gestation), * those who did not participate in more than one interview

Keywords: postpartum depression watson model psychoeducation breastfeeding
a study of toripalimab in combination with cisplatin and gemcitabine in participants with recurrent metastatic nasopharyngeal cancer

Conditions: Nasopharyngeal Cancer Recurrent

Summary: this study aims to investigate toripalimab with chemotherapy in participants with nasopharyngeal cancer.

the primary objective of this study is to evaluate the efficacy of toripalimab in combination with chemotherapy (cisplatin and gemcitabine), as measured by objective response rate (orr) assessed by a blinded independent central review committee (bicr) according to response evaluation criteria in solid tumors (recist) v1.1 in first-line recurrent metastatic nasopharyngeal cancer participants (both epstein-barr virus (ebv) and non-ebv-associated).

Eligibility criteria:
key inclusion criteria: * histological or cytological confirmation of recurrent/metastatic nasopharyngeal cancer with either ebv or non-ebv-associated cancer. the following subgroups are included: * eber/ebv-negative (hpv+/-) * eber/ebv-positive (hpv+/-) * recurrent/metastatic (stage iv-b as defined by the international union against cancer \[uicc\] and american joint committee on cancer \[ajcc\] staging system for nasopharyngeal cancer \[npc\], eighth edition) or recurrent npc after curative treatment. for recurrent npc, more than 6 months between the last dose of radiotherapy or chemotherapy and the date of recurrence. * measurable disease based on recist v 1.1 as determined by the site. note: lesions situated in a previously irradiated area are considered measurable if progression has been demonstrated in such lesions. key exclusion criteria: * disease that is suitable for local therapy administered with curative intent. * prior systemic therapy administered in the recurrent or metastatic setting. participants who develop disease recurrence within 6 months from curative intent chemoradiation will be excluded. * rapidly progressing disease (e.g., tumor bleeding, uncontrolled tumor pain) in the opinion of the treating investigator. * active or untreated central nervous system (cns) metastases (e.g., brain or leptomeningeal), as determined on computerized tomography (ct) or magnetic resonance imaging (mri) evaluation during screening and prior radiographic assessments. participants who have prior therapies for brain or leptomeningeal metastasis and have been stabilized ≥ 1 month and have discontinued systemic steroid therapy (\>10 mg/day prednisone or equivalent) ≥ 1 month prior to enrollment are eligible. other protocol-defined inclusion and exclusion criteria apply.

Keywords: programmed death 1 [pd1] inhibitor toripalimab recurrent metastatic nasopharyngeal cancer
relationship between pre-induction electroencephalogram pattern of adult patients and their sensitivity to propofol

Conditions: Propofol Overdose of Undetermined Intent

Summary: the induction dose of propofol is generally determined based on patients' characteristics, underlying disease, general condition, and also by clinician's experiences. however, it is difficult to anticipate and objectively calculate an adequate dose of propofol for every patient considering the variability of an individual's response to propofol. if there is a specific pattern in eeg prior to induction of anesthesia that can provide information about the patient's susceptibility to propofol, every induction may be performed far more smoothly with a precisely optimized dose of propofol for each patient. the study is to find a relationship between the pre-induction eeg pattern of adult patients and their sensitivity to propofol.


Eligibility criteria:
inclusion criteria: * adult patients undergoing general anesthesia exclusion criteria: * patients undergoing cardiac or brain surgery * patients with neurological deficit or impaired communication (glasgow coma scale \< 15) * unstable vital sign (cardiogenic, hemorrhagic, septic shock) * patients with eclampsia * patients who administered preoperative anxiolytics * patients who do not require intubation * patients who are considered unsuitable for the study
clinical performance evaluation of a glass-ionomer restorative system evaluation

Conditions: Dental Caries

Summary: the aim of this clinical trial was to compare the clinical performances of a glass ionomer restorative system with a micro hybrid resin based composite in class i and class ii cavities. a total of 140 (80 class i and 60 class ii) lesions in 59 patients were restored with a glass ionomer restorative system (equia) or a micro hybrid composite(gradia direct). restorations were evaluated at baseline and yearly during 9 years according to the modified-usphs criteria. data were analyzed with cohcran's q and mcnemar's tests (p\<0.05).

since the introduction of glass ionomers many modifications of these materials have been performed over the years. compared to other permanent filling materials like resin-based composites, glass ionomers show several advantages, such as the ability to adhere to moist enamel and dentin and anti- cariogenic properties such as the long-term fluoride release. so, it was doubtful that glass ionomers represent a capable counterpart of amalgam or resin-based composites in posterior teeth.

Eligibility criteria:
inclusion criteria: 1. a need for at least two but not more than four posterior toothcolored restorations; 2. the presence of teeth to be restored in occlusion; 3. teeth that were symptomless and vital; 4. a normal periodontal status; 5. a good likelihood of recall availability. exclusion criteria: 1. partly erupted teeth; 2. absence of adjacent and antagonist teeth 3. poor periodontal status; 4. adverse medical history; 5. potential behavioral problems.

Keywords: glass ionomer composite resin
efficacy and safety of thoracoscopic cryobiopsy in patients with undiagnosed exudative pleural effusion

Conditions: Pleura; Exudate

Summary: to demonstrated the efficacy and safety of taking biopsy specimens from parietal pleura in undiagnosed exudative pleural effusion

pleural effusions are either transudate or exudate according to the biochemical analysis of aspirated pleural fluid. thoracentesis or blind pleural biopsy may not provide a definitive diagnosis. cryobiopsy has more successful diagnostic results than forceps biopsies with complications (only hemorrhage) during procedures. cryobiopsy can obtain more diagnostic biopsies due to the size of the biopsies and best property in expressions of an artifact-free sample area

Eligibility criteria:
inclusion criteria: * patients diagnosed as exudative pleural effusion according to light criteria .informed written consents were taken from all patients enrolled in the study exclusion criteria: * patients who refused participation ,patients unfit for medical thoracoscopy (mt) will be excluded from the study such as:uncooperative patient ,severe uncorrected hypoxemia in spite of continuous oxygen administration, because it's necessary to keep oxygen saturation above 90 % during procedure ,patients who could not tolerate the lateral decubitus position for a period long adequate to do the thoracoscopy, unstable cardiovascular or hemodynamic condition, uncorrected coagulation defects and small pleural space
evaluation of motor imagery, cognitive function and reaction time in children with bronchiectasis

Conditions: Bronchiectasis

Summary: the aim of this study was to evaluate motor imagery ability, reaction time and cognitive function parameters in children with cf and non-cf bronchiectasis compared to healthy peers.

the main causes affecting exercise capacity in patients with bronchiectasis are restriction of tidal expiratory flow, dyspnea secondary to dynamic hyperinflation, changes in pulmonary mechanics, inadequate gas exchange and decreased skeletal muscle mass. due to all these symptoms, exercise capacity decreases in patients with bronchiectasis and the importance of physical activity increases. . in addition to decreased exercise capacity in individuals with bronchiectasis, studies on the effect of motor imagery ability, which is considered as a mental exercise, have not been found. inadequate blood supply to the brain and muscle dysfunction have been reported to cause cognitive damage and decreased reaction time in copd patients.

Eligibility criteria:
inclusion criteria: * diagnosed with cystic or non-cystic bronchiectasis * being clinically stable * not having an exacerbation or infection * being between the ages of 7-18 * to be able to read and understand turkish exclusion criteria: * unstable concomitant cardiac, orthopedic or neurologic disease * history of previous lung or liver transplantation * history of acute exacerbation and/or hospitalization in the last 1 month * changes in medical treatment during the study period.

Keywords: bronchiectasis cognitive function motor imagery
somatic stem cells in leiomyomas?

Conditions: Leiomyomas

Summary: the purpose of this study is to identify and characterize the somatic stem cell (ssc) responsible for the formation and growth of leiomyomas using the side population method.

the organ of interest in our study is the myometrium, a muscle layer of the uterus located between the perimetry and the endometrium. the investigators try to identify, locate and characterize the myometrial stem cell population in the uterine fibroids by isolation of "side population" by flow cytometry. once the investigators achieve the purposes to set out, the investigators would try to maintain "in vitro" stem cell population isolated from myometrial fibroids, for further endocrine characterization. finally, the investigators would try to induce the formation of fibroids in murine models as a first step to demonstrate that the origin of these formations is due to the abnormal proliferation of myometrial adult stem cells. the results of this study will allow the identification of the cell population in the fibroids. the investigators also can being able to compare with the myometrium in order to establish a relationship that helps us to understand more about the pathophysiology of this disease, using these stem cells as targets therapy in the treatment of this myometrium condition.

Eligibility criteria:
inclusion criteria: * clinical diagnosis for subserosal, intramural and submucosal fibroids. * aged between 20 and 40 years * signing of informed consent for collection and storage of biological samples. exclusion criteria: * contraindications for surgery. * failure to sign informed consent for collection and storage of biological samples.

Keywords: uterine fibroids somatic stem cell side population
multi-center, pediatric, open-label, preference study of desloratadine 2.5 mg reditab (sch34117) and zyrtec ® 5.0 mg chewable tablet medications (study p04573) (completed)

Conditions: Allergies

Summary: the primary objective of this study was to determine whether children ages 6-11 years prefer desloratadine reditabs (2.5 mg) or a marketed competitor (zyrtec® 5 mg chewable tablets). the secondary objectives of this study were to compare acceptance of the two attributes, taste and feeling in the mouth, of desloratadine 2.5 mg reditabs and zyrtec® 5 mg chewable tablets


Eligibility criteria:
inclusion criteria: * subject and the parent/guardian of the subject, was to have demonstrated their willingness to participate in the study and comply with its procedures by signing a written informed consent * 6-11 years old, either sex, either race * if female, subject to be premenarcheal * willing to avoid eating, drinking, gum chewing, and teeth brushing for one hour prior to enrollment. * free of any clinically significant disease that would interfere with study evaluations, including allergic rhinitis and respiratory infections. * able to adhere to the dosing and visit schedules exclusion criteria: * if female, subject who was pregnant, intended to become pregnant during the study or nursing. * subject had used any investigational product within 30 days prior to enrollment. * subject had any of the following clinical conditions: history of any significant medical conditions (based on reporting by parent or guardian): e.g., diabetes, heart disease, liver disease, kidney disease, breathing problems, cough with excessive phlegm, or persistent or chronic cough. * subject had a current medical condition that, in the opinion of the investigator or designee, may interfere with the ability to discriminate taste (e.g., common cold, sinus infection, bronchial infection, allergic rhinitis, etc.). * subject was participating in any other clinical study(ies). * subject was part of the staff or a family member of the staff personnel directly involved with this study. * subject was allergic to or has sensitivity to the study drug or its excipients. * subject had a history of allergic reaction to prescription and/or over the counter (otc) medications and/or food products. * subject had used any antihistamines within 24 hours prior to tasting as outlined in section 9.4.7. * subject used sedatives, tranquilizers, or monoamine oxidase inhibitor drugs.
long covid and post-exertional pulmonary diffusion

Conditions: Long COVID; Breathlessness; Exercise Intolerance; Alveolar Lung Disease; Pulmonary Gas Exchange

Summary: aim of investigators was to study whether abnormalities of lung diffusing capacity for nitric oxide (dlno) and carbon monoxide (dlco) in long covid may have a clinical impact in relation to exercise intolerance.

prolonged recovery from acute coronavirus disease 2019 (long covid) is characterized in about 30% of subjects from breathlessness and fatigue also during daily activities often associated to decreased lung diffusing capacity for carbon monoxide (dlco) at rest. aim of investigators was to study whether abnormalities of lung diffusing capacity for nitric oxide (dlno) and dlco in long covid may have a clinical impact in relation to exercise intolerance. combined dlno and dlco were simultaneously measured at rest and immediately after a short bout of treadmill walking in 32 dyspneic subjects ≥3 months after the covid-19 acute phase. a group of healthy subjects served as a control group.

Eligibility criteria:
inclusion criteria: * history of dyspnea, fatigue, and exercise intolerance persisting or occurring at least 3 months after the covid-19 acute phase and lasting ≥2 months. exclusion criteria: * history of diseases potentially causing dyspnea or affecting pulmonary gas transport, i.e., bronchial asthma, lung bullous disease, chronic obstructive pulmonary disease, pulmonary interstitial fibrosis or vasculitis, hematological diseases, systemic collagen diseases, congestive heart failure, liver or renal diseases, and morbid obesity.