Kornimate/medical-research-clean huggingface dataset:
gallstones and concomitant gastric helicobacter pylori infection

Conditions: Cholelithiasis

Summary: in this study, the presence of h.pylori in the gallbladder mucosa of patients with symptomatic gallstones undergoing cholecystectomy was investigated. concomitant h.pylori infection of the gastric mucosa was also investigated to study the relationship of gastric h.pylori infection to gallstones. it was hypothesized that h.pylori infection of the gastric mucosa may have a role in the formation of gallstones.

gallstone disease is one of the most common problems affecting the digestive tract where autopsy reports show a prevalence of 11-36% . the prevalence of gallstones is related to many factors including age, gender, and ethnic background. women are three times more likely to develop gallstones than man and first-degree relatives have a two-fold increased prevalence . however, the etiology of gallstone formation beginning with the change in the composition of bile, leading to stones is not clear. the association between helicobacter pylori (h.pylori) and gallstones has been investigated but not clearly demonstrated. h.pylori is a gram negative and micro-aerophilic microorganism that can cause chronic gastritis, gastric and duodenal ulcers, gastric adenocarcinoma and lymphoma of gastric mucosa-related lymphoid tissue (maltoma) . relationship of h.pylori with diseases of organs other than the stomach and duodenum has also been investigated and reported . h.pylori have been detected in the gallbladder mucosa of patients with gallstones . in this study, the presence of h.pylori in the gallbladder mucosa of patients with symptomatic gallstones undergoing cholecystectomy was investigated. concomitant h.pylori infection of the gastric mucosa was also investigated to study the relationship of gastric h.pylori infection to gallstones. it was hypothesized that h.pylori infection of the gastric mucosa may have a role in the formation of gallstones.

Eligibility criteria:
inclusion criteria: * patients with acute cholecystitis, cholangitis, biliary and hepatic tumors, crohn's disease, and previous gastric surgery were not considered suitable for evaluation. exclusion criteria: * patients undergoing ercp (endoscopic retrograde cholangio-pancreatography) and patients who have received h.pylori eradication treatment in the last 6 month were also excluded from the study.

Keywords: cholelithiasis gastric h.pylori infection h.pylori infection gastric mucosa
effectiveness of telerehabilitation on scleroderma

Conditions: Scleroderma; Scleroderma, Systemic; Scleroderma Associated Digital Ulcer; Hand Rheumatism; Physiotherapy; Rehabilitation

Summary: the effects of exercises performed by telerehabilitation on individuals with hand-affected scleroderma on range of motion, grip strength, function, sensation, daily life activities and general health will be compared with the effects of traditional physiotherapy practices.


Eligibility criteria:
inclusion criteria: * having been diagnosed with scleroderma * stability of medical treatments * to be able to adapt to the exercises exclusion criteria: * the patient has a history of neurological disease or trauma that may affect his symptoms * systemic involvement that affects the treatment process * being in the active phase of the disease

Keywords: scleroderma systemic sclerosis telerehabilitation hand therapy
optical coherence tomography (oct) trial in multiple sclerosis

Conditions: Multiple Sclerosis; RRMS

Summary: this is a 3-year, pharmacologically non-interventional study to evaluate oct as an outcome measure in patients with relapsing remitting multiple sclerosis (rrms). approximately 350 rrms patients, either untreated or treated with an approved ms disease-modifying therapy and approximately 70 reference subjects without ophthalmologic or neurologic disease are enrolled. no study medications are provided. patients on disease-modifying therapy are treated according to the local prescribing information. for each ms patient and each reference subject, the study consists of screening (up to 1 month), baseline, and a 36-month longitudinal data collection phase. eligibility will be confirmed during screening.


Eligibility criteria:
multiple sclerosis patients * a diagnosis of ms as defined by the 2005 revision to the mcdonald criteria with a relapsing-remitting course * ms disease duration of more than one year (from diagnosis of ms) before study entry healthy volunteers - matched to ms patients based on age, gender, ethnicity and visual refraction

Keywords: multiple sclerosis, ms, optical coherence tomography oct, rrms
a non-interventional survey on the egfr (epidermal growth factor receptor) mutation status in completely resected chinese non-small cell lung cancer (nsclc) patients with adenocarcinoma histology

Conditions: Non-Small Cell Lung Cancer

Summary: this is a descriptive observational study. the primary objective is to explore the egfr gene mutation status in early stage nsclc with adenocarcinoma histology after complete resection. the patients should be histological confirmed adenocarcinoma of the lung, have received complete resection and tested for egfr mutation in regular medical practice.


Eligibility criteria:
inclusion criteria: * histological diagnosed as adenocarcinoma type of non-small cell lung cancer * have completed lung cancer operation * the tumour egfr gene mutation status test was performed as regular medical practice exclusion criteria: * patients who disagree to participate this study

Keywords: egfr mutation test nsclc non-interventional study egfr mutation status
the gut microbiome in flt3-itd+ aml undergoing allo-hsct with or without sorafenib maintenance after allo-hsct

Conditions: Acute Myeloid Leukemia With FLT3/ITD Mutation; Allogeneic Hematopoietic Stem Cell Transplantation

Summary: this prospective trial investigates the effect of sorafenib maintenance therapy in flt3-itd aml patients after allo-hsct in terms of gut microbiome.

hematopoietic stem cell transplantation (hsct) is used as a potentially curative therapy for patients with hematopoietic malignancies. sorafenib, an inhibitor of multiple kinases including flt3, has shown promising activity in flt3-itd-positive aml. our previous studies demonstrated that sorafenib maintenance post-transplantation could improve the outcomes of flt3-itd-positive aml patients, which is associated with sorafenib enhancing the graft-versus-leukemia (gvl) effect. recent studies show that gut microbiome is associated with graft-versus-host-disease (gvhd) and gvl. however, the exact mechanism of sorafenib enhancing the gvl effect and the influence of gut microbiome on sorafenib maintenance after allo-hsct remain unknown.

Eligibility criteria:
inclusion criteria: * flt3-itd positive aml * allo-hsct recipients exclusion criteria: * intolerance to sorafenib pre-transplantation * cardiac dysfunction (particularly congestive heart failure) * hepatic abnormalities (bilirubin ≥ 3 mg/dl, aminotransferase\> 2 times the upper limit of normal) * renal dysfunction (creatinine clearance rate \< 30 ml/min) * any abnormality in a vital sign (e.g., heart rate, respiratory rate, or blood pressure) * patients with any conditions not suitable for the trial (according to the investigators' decision)

Keywords: hematopoietic stem cell transplantation gut microbiome sorafenib acute myeloid leukemia flt3-itd
effectiveness of modified constraint induced movement therapy to improve lower extremity function in the acute and subacute stroke patients by providing 1 hour of intense massed practice in the form of shaping or task practice

Conditions: Stroke

Summary: this is a prospective randomized control trial of patients with unilateral impairment of the lower extremity after stroke. patients will be randomized to intervention group and control group. intervention group will receive one hour of intense massed practice of lower extremity either in the form of shaping or task practice. control group will receive conventional physical therapy for 1 hour as per current standard of care that follows stroke clinical practice guideline.


Eligibility criteria:
inclusion criteria: * age 55 or older * new ischemic stroke as revealed by ct scan or mri of a brain or as per updated definition by american heart and american stroke association (sacco et al., 2013) * manual muscle testing with grad of \> 1+ in hip and knee joint musculature * able to walk atleast 10 feet indoors with or without assistance and assistive device. * motivated to participate and some initiation of flexion and extension movement in hip, knee and ankle joints. * ability to follow visual/verbal instructions as assessed by a minimum score of 24/30 points on the minimental state examination * fairly intact sensation exclusion criteria: * serious cardiac or pulmonary condition or other medical condition that make it difficult or risky to participate in intensive training * severe joint pain or degenerative disease to the musculoskeletal system of the lower extremity * other neurological disease 4) problems with following instructions.

Keywords: constraint induced movement therapy
integration of neurocognitive biomarkers into a neuro-oncology clinic

Conditions: Neurocognitive Disorders

Summary: this is prospective observational registry study that will assess 1) if the neurocognitive function app (brainlab cognition) can be used in a widespread neuro-oncology clinic setting and 2) if patient reported quality of life parameters can be obtained electronically and integrated into clinic.


Eligibility criteria:
inclusion criteria: 1. all adult (18+) patients with central nervous system (cns) tumors, both primary brain malignancies and brain metastases, treated with radiotherapy (partial brain, stereotactic radiosurgery, stereotactic fractionated radiotherapy, or whole-brain radiotherapy), surgery, and/or antineoplastic therapy and followed thereafter at miami cancer institute (mci) 2. life expectancy ≥ 6 months 3. willingness to participate in ongoing registration study exclusion criteria: 1. patients receiving radiotherapy to the brain for functional disease (arteriovenous malformations, trigeminal neuralgia, essential tremors, etc.) 2. pediatric patients (\<18 years old), pregnant women, and prisoners.

Keywords: neurocognitive brainlab cognition app
oral and systemic ammp-8 in periodontal disease

Conditions: Periodontal Diseases; Periodontal Inflammation

Summary: periodontal disease is an inflammatory process that can result in tooth loss and also is considered a modifying factor for systemic health. matrix metalloproteinase (mmp)-8 is the major collagenase of periodontal tissue breakdown. the aim of the present study is to analyze active (ammp-8) levels in gingival crevicular fluid (gcf), saliva and serum in the context of new criteria of gingivitis and stage 3 grade c periodontitis.


Eligibility criteria:
inclusion criteria: * systemically healthy and non-smoker individuals aged 25 to 50 years * having ≥20 teeth present (except third molars) * individuals with periodontally healthy, gingivitis and stage 3 periodontitis diagnoses exclusion criteria: * having any systemic disease * smoking * pregnancy or lactation * using antibiotic or any anti-inflammatory drug or any periodontal treatment within the past 6 months.

Keywords: periodontitis gingivitis matrix metalloproteinases
integrating nonpharmacologic strategies for pain with inclusion, respect, and equity

Conditions: Chronic Pain

Summary: inspire creates a trilingual mobile app and telehealth coaching program to promote non-pharmacologic strategies for pain management with black, chinese, and latinx communities in the san francisco bay area. years 1-2 will develop the app and test it with a brief single arm pilot starting in nov 2023. a full two arm randomized controlled trial (rct) will being in early 2025 with changes in peg scores as the primary outcome. secondary outcomes include helping to end addiction longterm (heal) common data elements.


Eligibility criteria:
inclusion criteria: 1. age 18 or older 2. speak english, spanish, or cantonese 3. have a ucsf health or sfhn pcp 4. be willing to use a smartphone (ios or android - either their own or one provided by the study) 5. have chronic, non-malignant pain for at least 3 months 6. be willing to participate in a 12 month patient-centered chronic pain management study where they will be randomized into one of two comparison arms exclusion criteria: * severe mental illness or other condition preventing informed consent

Keywords: non-malignant chronic pain digital health health coaching health equity cognitive therapy mindfulness movement
diffusion weighted magnetic resonance imaging for the characterization of solitary pulmonary lesions

Conditions: Thorax Cancer

Summary: the purpose of this study, is to investigate the value of diffusion weighted imaging on the differential diagnosis of solitary pulmonary lesions.

when a patient is diagnosed with a lung lesion, the differential diagnosis is important, since the treatment is determined by the lesion character. the goal in the evaluation of solitary pulmonary lesions is to distinguish malignant lesions from benign lesions in as non-invasive a manner as possible. as computed tomography is widely used, the diagnosis of solitary pulmonary lesions has become easier. the size, features of the edges, shape, internal structure (calcification, fat content, cavitation, etc.), density, satellite nodule, growth rate and contrast involvement of the lesion are important properties which help to distinguish benign lesions from malignant ones. however, as the distinction is not absolute at all times, other imaging methods such as positron emission tomography and magnetic resonance are preferred. the importance of this issue is the high five-year survival rate in early-diagnosed lung cancer cases. diffusion is the randomized microscopic motion of water molecules. it is known that diffusion is a sensitive parameter of tissue characterization at a microscopic level. nowadays, diffusion is measured in vivo with diffusion weighted mri and adc measurements. diffusion weighted imaging has a wide use on oncologic patients for the purpose of diagnosis. in addition, it is used in the distinction of acute cerebral infarction and epidermoid or arachnoid cysts. recently, it has also been used in the characterization of cystic or solid lesions in the thoracic cavity. in this study, the investigators aimed to evaluate the accuracy of differentiation of solitary pulmonary lesions.

Eligibility criteria:
inclusion criteria: * all patients had a solitary pulmonary nodule or mass. exclusion criteria: -

Keywords: diffusion weighted magnetic resonance imaging
laparoscopic sentinel lymph node localization in operable cervix cancer

Conditions: Cervical Cancer

Summary: the purpose of this study is to evaluate the feasibility, safety and efficacy of laparoscopic ovarian transposition in women less than 40 years of age with locally advanced cervical squamous cell carcinoma


Eligibility criteria:
inclusion criteria: * stage iai to iia cervix cancer undergoing primary surgical management exclusion criteria: * previous pelvic dissection * previous para-aortic lymph node dissection * evidence of distant mets
ultradian subcutaneous hydrocortisone infusion in addison disease and congenital adrenal hyperplasia

Conditions: Addison Disease; Adrenal Hyperplasia Congenital

Summary: the aim of this study is to compare the effects of tablet treatment, circadian and combined circadian and ultradian subcutaneous hydrocortisone infusion on steroid metabolism and tissue responses to therapy.

the conventional glucocorticoid replacement therapy in primary adrenal insufficiency (addison's disease) and congenital adrenal hyperplasia renders the cortisol levels unphysiological, which may cause symptoms and long-term complications. this therapeutical approach does not enable to restore physiological circadian and ultradian rhythm of glucocorticoids. current studies conclude that constant or unphysiological administration of glucocorticoids leads to abnormal gene transcription and causes sides effect of glucocorticoids treatment and long standing complications glucocorticoid replacement is technically feasible by continuous subcutaneous hydrocortisone infusion, which can mimic not only the normal diurnal cortisol rhythm, but potentially also the ultradian cadence. this is a pilot trial with an open cross-over design of 3 x minimum 2 weeks in 10 patients comparing the effects of tablet treatment versus continuous subcutaneous hydrocortisone infusion versus ultradian subcutaneous hydrocortisone infusion on serum, salivary, tissue hormonal response and glucocorticoid related gene expression.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of primary adrenal insufficiency 2. written informed consent exclusion criteria:. 1. diabetes mellitus 2. severe cardiovascular disease 3. active malignant disease 4. pregnancy or breast feeding 5. treatment with interfering drugs 6. intake of grapefruit juice

Keywords: addison disease adrenal hyperplasia congenital
diabetes education/skills training and social needs resolution intervention

Conditions: Type 2 Diabetes

Summary: this study will test the preliminary efficacy of a nurse case-manager, telephone-delivered intervention that provides diabetes self-management education and skills training and resolves the unmet social needs of older african americans with poorly controlled type 2 diabetes by randomizing 100 african americans aged 50 years and older with poorly controlled type 2 diabetes to the combined diabetes education/skills training and social needs resolution (dm social needs) intervention (n=50) and usual care (n=50) arms. the aims of this study are: aim 1: test the preliminary efficacy of the dm social needs intervention on clinical outcomes in older aas with uncontrolled type 2 diabetes. aim 2: test the preliminary efficacy of the dm social needs intervention on patient reported outcomes in older aas with uncontrolled type 2 diabetes.


Eligibility criteria:
inclusion criteria: 1. age 50 and older; 2. self-identified as african american or black; 3. self-reported diagnosis of t2dm; 4. hba1c \>=8% at the screening visit. exclusion criteria: 1. self-reported participation in other diabetes clinical trials; 2. alcohol or drug abuse or dependency as assessed by the cage-aid; 3. mental confusion at screening assessment suggesting significant dementia; 4. life expectancy \< 6 months at screening assessment.
gabapentin as an adjunct to perioperative pain management regimens for uterine aspiration

Conditions: Other Abortion; Spontaneous Abortion

Summary: this is a randomized controlled double-blind placebo-controlled trial evaluating the impact of gabapentin given preoperatively on perioperative pain scores for women receiving uterine aspiration between 6 and 14+6 weeks gestation. this study will be a trial included in a prospective meta-analysis evaluating the use of gabapentin on perioperative pain in the abortion setting.


Eligibility criteria:
inclusion criteria: * women \>=18 years-old * presenting for a surgical abortion * no contraindication to outpatient abortion * no contraindication to gabapentin * fluency in english and able to provide informed consent exclusion criteria: * allergy, sensitivity or contraindication to gabapentin * severe renal disease * currently using gabapentin or pregalabin

Keywords: uterine aspiration
effects rapid atrial pacing has on the electrocardiogram (ecg) in patients with dual chamber pacemakers

Conditions: Prolonged QT Interval

Summary: the purpose of this study is to learn what effect rapid atrial pacing (in patients with dual chamber pacemakers) will have on the electrocardiogram including the qt interval. the investigators are also interested in the differences caused by genes.

this study requires a total of two study days as well as two follow up visits. during study day one, baseline blood will be drawn, a baseline electrocardiogram will be performed, and continuous qt interval monitoring will be performed. the pacemaker rate will be increased to 90bpm at different time intervals and additional blood will be drawn to measure the effects of these rates changes. on study day two, baseline blood will be drawn, a urine specimen will be obtained, an electrocardiogram will be performed, and continuous qt interval monitoring will be performed. following the acquisition of this information, the pacemaker rate will be decreased to 80bpm. we will obtain blood specimens, a urine specimen and an electrocardiogram at 30 minutes post rate change and again at 60 minutes post rate change. two days following the rate decrease to 80bpm, the patient will return to clinic to have their rate decreased to 70bpm. in two more days, the patient will return for a final rate change to 60bpm.

Eligibility criteria:
inclusion criteria: * must be at least 21 years old * must have a dual chamber pacemaker implanted more than three months ago * must be followed by the vanderbilt university medical center's arrhythmia device clinic * the indication for the pacemaker must not be related to coronary artery disease (cad) or congestive heart failure (chf) exclusion criteria: * cannot be pacemaker dependent * history of ventricular arrhythmias and/or implantable defibrillators (icds) * history of paroxysmal, persistent, or permanent atrial fibrillation (af) * congenital long qt syndrome * history of coronary artery disease * history of, or currently receiving, treatment for congestive heart failure * unable to tolerate dual-chamber pacing (ddd) at 90 bpm due to palpitations, chest pain, shortness of breath, lightheadedness, dizziness, or presyncope * pregnant women * any patient without specific documentation of an echocardiogram negative for chf (systolic or diastolic dysfunction)within five years prior to study enrollment * any patient without specific documentation of an objective diagnostic test to rule out cad within five years prior to study enrollment

Keywords: qt interval dual chamber pacemaker atrial fibrillation