Kornimate/medical-research-clean huggingface dataset:
identifying markers of disease subtypes and disease progression in the syndrome of essential tremor

Conditions: Essential Tremor

Summary: the goal of this observational study is to learn about epidemiology, biologic markers, disease subtypes and possible prognostic factors in essential tremor (et) patients. the main question\[s\] it aims to answer are: * the prevalence of et-plus compared to et in a prospectively collected et population. * to assess in detail the heterogenous group of et patients using comprehensive clinical (motor and non-motor scales, questionnaires), imaging \[magnetic resonance imaging (mri), sonography of substantia nigra and cerebral vessels\], neurophysiological (tremor analysis, digital spiral drawing) and laboratory markers (sgfap, snfl, routine laboratory parameters). * to assess possible non-invasive markers of neurodegeneration in et patients (optic coherence tomography, alpha-synuclein in olfactory mucosa) participants will be asked to undergo the above mention evaluation at baseline and at follow-up approx. 5 years later. researchers will compare the findings within the et group to independently existing cohorts of healthy controls and/or patients with other movement disorders like parkinson's disease.


Eligibility criteria:
inclusion criteria: * presence of an essential tremor syndrome according to mds consensus criteria or suspected incipient essential tremor (differential diagnosis vs. enhanced physiological tremor) * patient is able and willing to give informed consent. * age above 18 years. exclusion criteria: * patient is not able or not willing to give informed consent. * existence of a legal representative. * age below 18 years

Keywords: essential tremor subtypes neurodegeneration biomarkers mri imaging sgfap snfl tremor analysis
chinese medicine periodic therapy for dysfunctional uterine bleeding during adolescence with yin deficiency and blood heat syndrome

Conditions: Dysfunctional Uterine Bleeding

Summary: the purpose of this study is to conduct a randomized, single blind, controlled intervention trial to observe the therapeutic effect of kidney-tonifying and tune up chong-ren hemostasis chinese medicine periodic therapy for dysfunctional uterine bleeding based on objective chinese and western medicine evaluation standard.

dysfunctional uterine bleeding during adolescence is the most common menstrual disorders during adolescence, and the age of children suffering from it tended to be lower. it's urgent to explore effective ways to alleviate the pain caused by dysfunctional uterine bleeding. in our research, 160 children are randomly divided into a chinese medication periodic therapy group (80 cases) and a gong xue ning control group (80 cases). paticipants in chinese medication periodic therapy group are treated with kidney-tonifying and tune up chong-ren hemostasis chinese medicine for 3 months, whereas the gong xue ning control group received gong xue ning capsules for 3 months. we compare the effect of the two therapies about hemostasis and menstruation regulation, and the change of the thickness of endometrium, sex hormones, kisspeptin, and pai-1 in blood before and after the treatment, in order to make clear the efficacy and the mechanism of the chinese medicine periodic therapy.

Eligibility criteria:
inclusion criteria: * satisfy the diagnostic criteria in the textbook\ with dysfunctional uterine bleeding * age between 10-18 years * course of the disease is 2 months or more. exclusion criteria: * have uterine bleeding on account of systemic diseases or organic diseases in reproductive system, such as blood diseases, thyroid diseases, hepatic diseases, etc. * hb\<80g/l * have mental disorders * allergic to many kinds of drugs
comparison of urine protein/creatinine ratio with 24-hour urine protein excretion in woman with hypertensive disorders

Conditions: Hypertension, Pregnancy-Induced

Summary: the presence of proteinuria (\>300 mg/d) represents an important factor in the diagnosis and evaluation of the pregnant patient with an hypertensive disorder. the 24 hour collection of urine for proteinuria is the gold standard for the diagnosis of the condition and allows the physician to determine if an hypertensive disorder is related directly or not to the gestation. the problem is the time it takes and the technical difficulties related to the sample collection. an alternative is the quantification of protein and creatinine in a random sample of urine. we seek to evaluate if this method is as affective as the gold standard in the diagnosis of proteinuria (\>300 mg/d).


Eligibility criteria:
inclusion criteria: * pregnant women with 28 weeks or more of gestation. * complete collection of the 24 hour urine sample. exclusion criteria: * failure to recollect the 24 hour urine sample. * pregestational diabetes * kidney disease * 24 hour urine protein \> 8.0 g/dl or seric creatinine \> 2.0 mg/dl (it could indicate kidney disease).

Keywords: hypertension 24 hour urine protein protein/creatinine ratio
adipogenic capacity as a mediator of weight gain

Conditions: Obesity

Summary: to demonstrate differences in response of subjects with a high, low or medium predisposition for weight regain after weight reduction in terms of: body composition; energy expenditure; physical activity; and adipogenic capacity.

the risk for weight regain after weight loss is a major problem for the current obesity treatments, and is largely genetically determined. it is believed that an elucidation of the genetic component in the prognosis of weight management could assist in the development of more effective and individually tailored treatments. however, current research on the genetic component of weight management, and in particular weight regain, is still limited and data available are sometimes inconsistent. the current research proposal aims to identify groups with a high, low or medium predisposition for weight regain, based on a genetic profile and to demonstrate differences in the response of these subjects to a weight maintenance period after weight reduction in terms of body composition, physical activity, adipogenic capacity and energy expenditure.

Eligibility criteria:
inclusion criteria: * bmi 28-35 * healthy, no medication * no smoking * stable weight (no weight loss/gain \> 5kg in 3 months prior to study) exclusion criteria: * 28\ 35 * use of medication * smoking * weight loss/gain \> 5kg in 3 months prior to study

Keywords: weight loss and maintenance body composition energy expenditure adipogenic capacity physical activity
inherited genetic susceptibility in langerhans cell histiocytosis (lch)

Conditions: Histiocytosis, Langerhans-Cell

Summary: the long-term goal is to define the mechanisms of pathogenesis underlying langerhans cell histiocytosis (lch). the overall objectives of the current study are to characterize the role of smad6 inherited genetic variation on lch susceptibility and identify germline genomic regions associated with lch somatic mutations. building from preliminary data, the central hypotheses are: (1) causal genetic variants in smad6 underlie susceptibility to lch, and (2) differences in lch-related somatic activating mutations by race/ethnicity are related to amerindian (i.e., native american) genetic ancestry. the central hypothesis will be tested by pursuing the specific aims.

primary objectives: i. to comprehensively characterize germline variants in smad6 and their association with lch. ii. to identify novel germline variants associated with lch. iii.to determine the role of genetic ancestry on lch-related somatic mutations. exploratory objectives: i. to integrate clinical and epidemiologic questionnaire data with genetic risk factor data from the primary aims to more comprehensively elucidate lch susceptibility. outline: case identification and recruitment followed by questionnaires and specimen processing.

Eligibility criteria:
inclusion criteria: * ≤ 25 years old at the time of original lch diagnosis * the patient must be enrolled on accrn07 and/or apec14b1 and registered with cog by a north american member institution * the patient must have a diagnosis of lch (icd codes/morphology: 9751/1; 9752/1; 9753/1; or 9754/3). * the patient must be diagnosed with lch on or after january 1, 2008. * all questionnaire respondents must understand english or spanish. * all patients and/or their parents or legal guardians must provide informed consent. * all institutional, fda, and nci requirements for human studies must be met.
home based resistance training for type 2 diabetes

Conditions: Diabetes

Summary: this study will investigate the biological and psychosocial benefits of a home-based resistance-training program for sedentary, obese adults living with type 2 diabetes.

obese individuals with type 2 diabetes will be randomly assigned to either an experimental group where they will perform moderate to high intensity resistance training (50-60% 1rm weeks 1-3 and 70-85% 1rm in weeks 4-16) three times per week for 16 weeks or to a non-training control group. all resistance training will be performed at home using a multigym apparatus. a personal trainer (pt) will come to the homes of each participant in the experimental group to make sure that exercises are being performed safely with the correct technique, and at the prescribed intensity. in the first two weeks, the pt will come to all 3 sessions per week. in weeks 3-4 this will be reduced to 2 times per week, in weeks 5-8 the pt will come once per week and in the last 8 weeks once bi-weekly.

Eligibility criteria:
inclusion criteria: type 2 diabetes overweight and obese (bmi\>28) living inside of city limits exclusion criteria: ischemic heart disease osteoporosis musculoskeletal abnormalities currently performing resistance training

Keywords: diabetes resistance training
retrospective evaluation of prosthetic complications and peri-implant bone resorption in implant-supported single unit fixed restorations

Conditions: Implant Clinical Survival; Restoration Survival

Summary: this study evaluated the one-year outcomes of implant-supported single-tooth fixed restorations used to replace missing teeth. the aim was to assess the success rates of dental implants and identify potential complications during treatment. a total of 100 individuals aged between 20 and 64 participated in the study. patients were evaluated one year after their implant treatments through clinical examinations and radiographic imaging.

aim: the aim of this study was to retrospectively investigate the prosthetic complications and peri-implant bone loss by clinical and radiological examination at the 12th month of implantsupported single-unit fixed restorations. materials and methods: in this retrospective study, 100 volunteer patients, aged between 20 and 64, who received implant-supported single-member fixed restoration treatment, were scanned from the archives and included. the patients were scanned from the archives, called for 12-month follow-ups, and clinical and radiographic evaluations were made. g\*power (g\*power ver. 3.0.10, franz faul, üniversität kiel, germany) package program was used to calculate the sample size. digital radiographs (periapical-panoramic films) taken from the patients at the end of the implant treatment and at the 12th month follow-up were recorded using planmeca romexis® software. imagej, a digital image analysis program, was used to evaluate marginal bone loss on radiographs (imagej 1.54g- wayne rasband and contributons, national institutes of health, usa). in evaluating the success and survival of the implants, the criteria in the consensus decisions published at the international oral implantology congress in 2007 were taken as basis. in addition, prosthetic complications such as chipping, screw loosening and decementation; its relationship with anatomical localization, implant length, implant diameter, abutment type, superstructure material, occlusal table and the condition of the opposing arch was evaluated.

Eligibility criteria:
inclusion criteria: * participants were required to be over 18 * not to have any systemic disorders * not to smoke * have provided consent to the study. exclusion criteria: * individuals with any systemic or psychiatric disorders * who did not have radiographic data immediately after prosthetic loading

Keywords: dental implant implant supported fixed prosthesis prosthetic complication bone loss
surgical bypass versus hybrid approaches for critical limb ischemia

Conditions: Critical Lower Limb Ischemia

Summary: the present randomized study proposed to compare the immediate postoperative and 2-year clinical outcomes of long surgical bypass and hybrid approaches in patients with multilevel critical lower limb ischemia.


Eligibility criteria:
inclusion criteria: * tasc ii type d femoropopliteal lesions with intact ipsilateral femoral pulse. * fontaine classification stage iv (gangrene or necrosis). * rutherford grade iii and iv category 5 and 6 with salvageable foot exclusion criteria: * heart failure * liver failure * renal impairment
microrna in thyroid cancer

Conditions: FNA; microRNA; Thyroid Cancer; Thyroid Nodule

Summary: thyroid cancer is the most common endocrine malignancy and its incidence is rapidly increasing. palpable thyroid nodules are very common, affecting up to 5% of the general population. nevertheless, only 5% of the thyroid nodules harbor malignancy, hence the obvious need to accurately characterise these nodules. ultrasound guided fine needle aspiration biopsy (fnab) is the most important tool in assessing the nature of thyroid nodules, however, in up to 30% of the biopsies the results are indeterminate. in this proposal, the investigators hypothesize that leftover cells in the fnab needle may be utilized for molecular analysis with an established microrna panel and distinguish between malignant and benign lesions. despite established studies on the diagnostic utility of micrornas in thyroid nodules, the effect of micrornas on specific target genes involved in thyroid cancer is poorly studied. in this proposal the investigators hypothesize that the micrornas identified in our panel will affect intracellular pathways by regulating target genes that are involved in thyroid tumorigenesis. the investigators present preliminary data that confirms that microrna panel may identify malignancy in thyroid nodules. in aim 1 the investigators will identify the expression profile of mirnas in the different thyroid cancers. the investigators will statistically quantify the threshold of mirna dysregulation for malignancy on a large number of tumor and benign samples. this will serve as matrix for defining malignancy on the fnab samples. in aim 2 the investigators will establish a reliable reproducible method to extract rna from cells left over in fnab samples. the investigators' preliminary data support the feasibility of the method and it has not been described previously. this will be the first study that will compare cytology results and microrna panel analysis on the very same fnab cells. it will mimic the exact clinical scenario that such microrna panel can be utilized in the future. finally, in aim 3 the investigators will characterize the effect of micrornas on target genes expression. the investigators will identify possible target genes from bioinformatics databases and will perform quantitative measurement of mrna level of target gene by real time pcr and immunohistochemistry. these studies will hopefully support the utility of micrornas as a diagnostic tool to accurately identify malignancy in thyroid fnab leftover cells and point out possible target genes for future therapeutic approaches. this could impact many patients, as thyroid cancer is the 5th most common cancer in women, and the most rapidly growing malignancy in both men and women.


Eligibility criteria:
inclusion criteria: * patients undergoing thyroid nodule biopsy; patients signing informed consent exclusion criteria: * patients that cannot sign an informed consent form.
clinical trial on the reduction of methicillin resistant staphylococcus aureus (mrsa)

Conditions: Skin Ulcers; Methicillin-resistant Staphylococcus Aureus Infection

Summary: the purpose of the study is to determine if topically applied nitric oxide gas is effective in reducing the quantity of bacteria (including mrsa)in a wound.


Eligibility criteria:
inclusion criteria: * must have given written informed consent * must be ≥ 18 years of age and not of child bearing potential * must have an ulcer in which the presence of mrsa has been identified, but which is not clinically infected * must have an ulcer size not to extend beyond the inner borders of the dressing exclusion criteria: * is a female of child bearing years or who could become pregnant * is \< 18 years of age * has an clinically infected skin ulcer * has a ulcer that is being treated with a topical antimicrobial agent or has been treated with a topical antimicrobial agent during 3 days prior to enrolment * has been using systemic antibiotics during 7 days prior to enrolment into this study * has an ulcer which is identified as malignant in origin (e.g. marjolin's ulcer) * has an ulcer size beyond the inner borders of the dressing * is septic or has other signs of an invasive infection * has used any investigational drug within 30 days preceding study participation. * suffers from a condition, which, in the opinion of the investigator, would compromise his or her safety. * suffers from a condition which, in the opinion of the investigator, would compromise the quality of the data. * has a known allergy to any of the products that are part of this protocol * suffers from a condition which, in the opinion of the investigator, would seriously interfere negatively with the normal parameters of immune response to an infection. * is using any of the prohibited concomitant medications or treatments
comparative retrospective analysis of skin tumors of the eyelids and face in 2 brussels university hospitals over 5 years in dermatology or ophthalmology

Conditions: Skin Cancer

Summary: skin cancers are the most common of all cancers. their incidence has increased sharply over the decades.this increase in incidence partly reflects an aging population and behavioral patterns such as repeated exposure to the sun. indeed, exposure to uv rays is the predominant factor involved in the pathogenesis of these tumors, hence the fact that they mainly develop in photo-exposed regions such as the cephalic extremity. the objective of this study is to provide an epidemiological analysis of tumors in the populations of both chu brugmann and st pierre hospitals.


Eligibility criteria:
inclusion criteria: final diagnosis confirmed by pathological analysis, epidemiological and clinical information available from patients. exclusion criteria: patients who have expressed a refusal to access their medical file or incomplete data will not be taken into account.
trial of asthma patient education (tape)

Conditions: Asthma

Summary: the purpose of this research study is to investigate the way that educational approaches and presentation of a drug may affect the response to montelukast and placebo (an inactive medication) in subjects with asthma.

this is a study of the effects of education and drug presentation on efficacy of montelukast and placebo in asthma. this trial will answer the following questions: 1) is there a true placebo response in asthma that is not due to non-specific factors? 2) can the placebo effect in asthma be augmented by interventions that increase expectancy of benefit? 3) can interventions that increase expectancy augment the effect of active treatment? 4) are placebo effects additive or interactive with treatment effects?

Eligibility criteria:
inclusion criteria: * age 15 or older * physician diagnosed asthma * regular use of prescribed asthma medication over preceding year * post-bronchodilator fev1 of at least 75% of predicted * inadequate asthma control over preceding two months exclusion criteria: * current or past smoking (greater than 10 pack-years) * serious asthma exacerbation within previous three months * regular use of oral corticosteroids * history of respiratory failure due to asthma * current use of montelukast or history of adverse reaction to montelukast * concomitant interfering medical condition * participation in another clinical trial * inability or unwillingness to perform study procedures * pregnancy, lack of effective contraception (when appropriate), lactation

Keywords: asthma placebo education
surgical treatment for acute patella tendon rupture

Conditions: Acute Patella Tendon Rupture

Summary: we will compare two groups for acute patella tendon repair: one treated with surgical anchors and the second, with transpatellar tunnels.

the patella tendon is located in the knee, and is attached to the leg bone and the patella bone (knee cap). the quadriceps muscle (an important tight muscle) attaches to the patella bone and allows for extension and flexion of the leg. rupture of the patella tendon occurs mainly in people under the age of 40 years old with an active lifestyle. normally, surgical repair is needed to fix this injury. the widely accepted surgery for this injury consists in drilling 2 holes in the patella bone that are used to anchor the patella tendon in place. this surgery has some complications such as re-rupture of the tendon, breakage of the bone, etc. some investigators have tried different techniques to avoid these complications with variable results. we want to use 2 anchors in the bone to avoid making holes in the patella bone, decreasing complications and surgical time, and hopefully, allowing for a better surgical repair. we will have 2 arms. one group will have the standard of care technique and the second group will have the anchors technique. we will follow up with our patients after the surgery to record their progress, and complications, if any. we will also have a standardized physical therapy program for consistency and to avoid any problems.

Eligibility criteria:
inclusion criteria: 1. stage of disease: acute ruptures of the patella tendon, no more than 3 weeks since the time of injury. 2. age: 18 years old and up. 3. performance status: patients with no other previous illnesses that prevented them to ambulate normally (without help of devices). 4. informed consent requirements: one person from our research staff will approach the patient after the diagnosis has been made. the diagnosis will be made by the doctor in charge on the patient care based on the medical history, physical exam and image studies (mri). we will explain the benefits/risks to be part of the study and that they are not obligated to be part of it as part of their care. exclusion criteria: 1. prior treatment: patients with chronic patella tendon ruptures (more than 3 weeks). 2. prior other diseases: diseases with systemic collagen deficiencies. 3. infection: patients with active infection will be disqualified.

Keywords: patella tendon rupute, suture anchors, repair patella tendon