Kornimate/medical-research-clean huggingface dataset:
a pilot study of spg block for ptsd

Conditions: Post Traumatic Stress Disorder

Summary: some patients with post traumatic stress disorder (ptsd) respond only partially to medication. this study is a pilot study investigating whether blocking the spg helps reduce the symptoms of ptsd. this study does not involve treatment with medications. it is a proof of principal study.

the sphenopalatine ganglion (spg) is a collection of neurons involved in autonomic regulation (which refers to bodily processes that are automatic like heart rate and blood pressure). blocking the spg is used to treat disorders, such as migraines or cluster headaches (short, severe headaches that occur together). the procedure will be performed by a doctor who specializes in ear, nose throat surgery. the block consists of the injection of a numbing agent (similar to the type used by dentists) to the spg. after the spg block, we will follow patients for 8 weeks to see how they feel.

Eligibility criteria:
inclusion criteria: * participants with a principal diagnosis of ptsd on stable dose of psychiatric medication or in stable psychotherapy for at least 3 months, who experience residual symptoms. * participants who understand all study procedures and can undergo informed consent exclusion criteria: * participants with a medical disorder, for whom study participation could be deleterious (neurologic, cardiac, renal or infectious disease) * pregnant or breast feeding participants * participants who are on an anticoagulant, such as warfarin, or otherwise have a medical condition that increases bleeding risk
subtalar arthrodesis by single versus double screws

Conditions: Subtalar Osteoarthritis Secondary to Inflammatory Arthritis

Summary: compare clinical and radiological outcome of use of single screw versus double screws fixation for subtalar arthrodesis

the subtalar joint consists of an anterior, posterior and medial joint facet, which allows for inversion - and eversion of the foot. several pathologies may lead to pain originating from the subtalar joint, including primary arthritis, posttraumatic arthritis, congenital or acquired deformities, instability, tarsal coalition or inflammatory diseases management of these pathologies variable including conservative and operative treatment once conservative treatment has failed subtalar fusion is a common surgical procedure which is a well-established and widely accepted there are many surgical techniques described for fusion , one of these techniques is fixation with screws the rate of non-union varies among authors between 0-46%, that's may due to lack of standardization of techniques should be used

Eligibility criteria:
inclusion criteria: * all patients who will be operated by subtalar fusion for any indication age range 18 - 65 exclusion criteria: * age \ 65 acute calceneal fracture infection non union bone defect that need bone graft refusing to participate in the study

Keywords: subtalar arthrodesis screws
docetaxel in treating older patients with metastatic breast, lung, or prostate cancer

Conditions: Breast Cancer; Lung Cancer; Prostate Cancer

Summary: rationale: drugs used in chemotherapy, such as docetaxel, use different ways to stop tumor cells from dividing so they stop growing or die. purpose: this phase ii trial is studying how well docetaxel works in treating older patients with metastatic breast, lung, or prostate cancer.

objectives: * determine the pharmacokinetics of docetaxel in older patients with metastatic breast, lung, or prostate cancer. * determine the response of patients treated with this drug. * determine the toxicity of this drug in these patients. * determine the short-term changes in functional status, in terms of activities of daily living, independent activities of daily living, and karnofsky performance status, in patients treated with this drug. * correlate the number of comorbid conditions at baseline with declines in functional status in patients treated with this drug. outline: patients receive docetaxel iv over 30 minutes once weekly for 3 weeks. courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity. projected accrual: a total of 20 patients will be accrued for this study within 1 year.

Eligibility criteria:
disease characteristics: * histologically proven metastatic breast, lung, or prostate cancer * measurable disease * no untreated cns metastases * no symptomatic cns metastases requiring escalating doses of corticosteroids * hormone receptor status: * not specified patient characteristics: age * 65 and over sex * not specified menopausal status * not specified performance status * karnofsky 70-100% life expectancy * not specified hematopoietic * absolute neutrophil count at least 1,500/mm\^3 * hemoglobin at least 8.0 g/dl * platelet count at least 100,000/mm\^3 hepatic * bilirubin normal * sgot and/or sgpt no greater than 2.5 times upper limit of normal (uln) with alkaline phosphatase no greater than uln or * alkaline phosphatase no greater than 4 times uln with sgot and sgpt no greater than uln renal * not specified cardiovascular * no history of cardiac arrhythmia * no congestive heart failure * no myocardial infarction within the past 6 months other * no prior severe hypersensitivity reaction to docetaxel or other drugs containing polysorbate 80 * no allergy to macrolide antibiotics * no grade 2 or greater peripheral neuropathy * no concurrent serious or uncontrolled infection * able to read, write, and converse in english prior concurrent therapy: biologic therapy * not specified chemotherapy * recovered from prior chemotherapy endocrine therapy * see disease characteristics radiotherapy * recovered from prior radiotherapy surgery * not specified other * no concurrent cyp3a4-inducing or inhibiting medications or herbal remedies * no concurrent grapefruit juice * no concurrent ethanol

Keywords: stage iv breast cancer stage iv non-small cell lung cancer recurrent non-small cell lung cancer recurrent breast cancer stage iv prostate cancer recurrent prostate cancer
the character of perfusion parameters derived from mdct between adenocarcinoma and squamous cell carcinoma of lung in the treatment course of radiation therapy

Conditions: Adenocarcinoma; Squamous Cell Carcinoma; Relevant Condition Terms to the Conditions Field

Summary: lung cancer is one of the leading causes of cancer-related death in taiwan. recently, there are more treatment methods available which result in increased patient survival. although adenocarcinoma and squamous cell carcinoma were both categorized as non-small cell lung cancer (nsclc), the recent advancement of target therapy implied that these two histologies behave differently (shah nt, et al. 2005; sandler a, et al. 2006). radiation therapy is an important method for locally advanced non-resectable non-small cell lung cancer (nsclc). computed tomography (ct) is the mainstay for evaluating lung cancer. the advance of multi-row detector ct (mdct) provides volumetric acquisition within a breath hold, and enables detailed evaluation of tissue and organ perfusion with excellent resolution. using this new technique with image post processing, excellent spatial resolution and functional perfusion information can be obtained simultaneously. therefore, the purpose of this study is to explore not only the longitudinal change of lung cancer eligible for radiation therapy (including concurrent, sequential chemoradiotherapy and high-dose radiation therapy) but also comparison of adenocarcinoma and squamous cell lung cancers using perfusion mdct. total twenty patients with histopathologically proved adenocarcinoma or squamous cell carcinoma will be enrolled in this study and receive longitudinal study for perfusion mdct evaluation before, during radiation therapy and in early and late phases after complete radiation therapy. dynamic perfusion will be used for processing the image data, and quantitative parameters such as tumor blood volume and permeability etc will be derived. from this study, we expect to understand the change of tumor vascularity after radiation therapy and characters of treatment response of adenocarcinoma and squamous cell carcinoma in addition to the change of tumor size.


Eligibility criteria:
inclusion criteria: * ages 18 and up * males and females exclusion criteria: * pregnancy

Keywords: to evaluate the longitudinal change of tumor perfusion in the course of radiation therapy in adenocarcinoma and squamous cell carcinoma using perfusion mdct comparison between adenocarcinoma and squamous cell carcinoma will be evaluated according to the derived perfusion parameter obtained from perfusion mdct
comparison of semitendinosus and quadriceps grafts for anterior cruciate ligament reconstruction

Conditions: ACL; ACL Injury

Summary: to investigate the differences between the two methods for reconstruction of the anterior cruciate ligament (acl), to support the development of the best method for young federated male football players. after surgery with quadricipital tendon graft or semitendinosus tendon graft, a two-year follow-up and the rate of return to sport are proposed.

the anterior cruciate ligament is one of the most common traumatic injuries in football, and surgery is proposed to restore knee stability. however, following surgery, few studies have focused on functional recovery of the knee with a wide arsenal of physical tests. therefore, this study aims to study the efficacy for young football players of two types of grafts based on the most common tendons, the quadricipital and the semitendinosus (without the semimembranosus). follow-ups will be performed at three months, six months, one year and two years after reconstruction. the variables measured will be isokinetic strength of flexors and extensors, unipodal jump test, self-perceived function, pain and tendon architecture with ultrasound.

Eligibility criteria:
inclusion criteria: * confirmed anterior cruciate ligament rupture by mri. * prognosis of anterior cruciate ligament reconstruction surgery. * be a registered or recreational football player. exclusion criteria: * previous knee surgery. * having articular cartilage lesions of outerbridge grade greater than iii-iv.
mgta-145 + plerixafor in the mobilization of hematopoietic stem cells for autologous transplantation in multiple myeloma

Conditions: Multiple Myeloma

Summary: this study evaluates a new drug mgta-145 in combination with plerixafor (mozobil) to mobilize stem cells into the peripheral blood for collection by apheresis. the stem cells will be used for autologous stem cell transplant for treatment of multiple myeloma.

primary objective 1. to assess the efficacy of mgta-145 in combination with plerixafor in mobilizing adequate number of hematopoietic stem cells (\> 2 x 10e6 cd34+ cells/kg) in patients with multiple myeloma (mm) in preparation for autologous stem cell transplantation (asct). secondary objectives 1. to assess the efficacy of mgta-145 and plerixafor in mobilizing different hematopoietic stem cells (hscs) target goals in patients with mm in preparation for asct. 2. to assess the safety and tolerability of mgta-145 and plerixafor for mobilizing hscs in patients with mm. 3. to assess the engraftment rate and time to engraftment following asct after hsc mobilization with mgta-145 and plerixafor in patients with mm undergoing upfront asct. 4. to assess rate of ongoing engraftment at day 30 and 100 after stem cell infusion in patients with mm who are mobilized with mgta-145 and plerixafor undergoing upfront asct. 5. to assess transplant and disease-related outcomes after mobilization of hscs with mgta-145 and plerixafor in patients with mm undergoing upfront asct.

Eligibility criteria:
inclusion criteria: * diagnosis of multiple myeloma (mm) per the international myeloma working group (imwg) criteria * eligible for autologous stem cell transplantation (asct) per institutional guidelines * within 1 year of start of therapy for multiple myeloma * cardiac and pulmonary status sufficient to undergo apheresis and transplantation per institutional transplant guidelines * calculated creatinine clearance \> 30 ml/min, according to the modification of diet in renal disease (mdrd) formula. * absolute neutrophil count (anc) \> 1500 x 10e6/l * platelet count \> 100,000 x 10e6/l * ability to understand and the willingness to sign a written informed consent document. * agreement to use an approved form of contraception for male patients or female patients of childbearing potential. exclusion criteria: * history of prior stem cell transplant for multiple myeloma or other indications * planned tandem stem cell transplant * prior history of failure to collect hscs. * total bilirubin \> 1.5x upper limit of normal (uln) in the absence of a documented history of gilbert's syndrome * aspartate aminotransferase (ast)/alanine aminotransferase (alt) \> 3x uln * known allergy to mgta-145 or plerixafor. * lifetime exposure to lenalidomide or another immunomodulatory drug greater than 6 cumulative months of treatment, ie, \> 6 cycles of 28 days or \> 8cycles of 21 days * pregnant or lactating
the vital signs to identify, target, and assess level (vital) care study iii

Conditions: Cardiac Arrest; Renal Failure; Respiration Failure; Myocardial Infarction; Severe Sepsis

Summary: to evaluate the effect of automated recording on frequency of recorded scores, number of automated notifications and serious events.

the frequency of ews scores, number of automated notifications and serious events performed on a general ward is contingent on the quality and frequency of vital signs measurement like respiratory rate. this is due to the ews escalation schemes of hospitals with an acute intervention team. obtained sub-score trigger levels of vital signs contribute to higher and more frequent scoring. we examine the influence of different respiration rate sensor concepts and measurements on scoring (news and crews) and workflow in a typical uk gastroenterology and respiratory ward.

Eligibility criteria:
inclusion criteria: * patients admitted to the study units during the period of data collection exclusion criteria: * palliative patients

Keywords: early warning scoring respiration rate acute care teams news crews
pathway and urgent care of dyspneic patient at the emergency department in lorraine district (purple)

Conditions: Acute Dyspnea

Summary: this is an observational prospective multicenter study of patients admitted for acute dyspnea in an emergency department of the participating centers in the lorraine district. the primary objective is to assess the outcome of this population according to the cause of acute dyspnea as well as identify the predictors of this outcome, both overall and according to each acute dyspnea cause.

this observational prospective multicenter study will be conducted using data from electronic medical records, acquired as part of usual care, in patients admitted for acute dyspnea in the emergency department. clinical, treatment, laboratory and imaging data acquired during the hospitalization (in the emergency department and in the department that admitted the patients following the emergency department stay) will be collected. vital status will be recorded at 30 days and 1 year post-admission.

Eligibility criteria:
inclusion criteria: * men or women \> or = 18 years. * patients with acute dyspnea admitted for acute dyspnea in the emergency department. * patient informed. exclusion criteria: * cardiorespiratory arrest. * patient having expressed his or her opposition.

Keywords: acute dyspnea acute heart failure emergency
when do we have to perform cardiac magnetic resonance in patients referred for premature ventricular complexes by their cardiologists

Conditions: Premature Ventricular Complexes; Ventricular Arythmias; Cardiac Magnetic Resonance Imaging; Focal or Diffuse Fibrosis; Structural Heart Disease; Idiopathic

Summary: premature ventricular complexes (pvc) are a common entity affecting approximatively 20% of the general population. it can be discovered incidentally on electrocardiogram (ecg) or associated with symptoms with a wide spectrum from palpitations, chest pain, to syncope. the initial and non invasive assessment includes holter ecg monitoring, a transthoracic echocardiography (tte) and an exercise stress test to rule out structural heart disease (shd), and referred to as benign or "idiopathic" ventricular arrhythmias (iva). however, these exams may fail to identify subtle myocardial abnormalities such as arrhythmogenic right ventricle dysplasia (arvd), apical hypertrophic cardiomyopathy, healed myocarditis, ischemic or non-ischemic cardiomyopathies. cardiac magnetic resonance (cmr) imaging is the gold standard modality to assess regional and global ventricular function. it is also a unique modality to non-invasively detect myocardial edema, myocardial fatty replacement, focal and diffuse fibrosis and could potentially identify shd in patients with pvc. however, the role of cmr is uncertain, recommended in case of atypical presentation or when the initial assessment can't exclude a cardiomyopathy (recommendations class iia). this study sought to determine whether and when cmr can be performed to provide diagnosis or prognostic information complementary to initial assessment in patients referred for pvc by their cardiologists.


Eligibility criteria:
inclusion criteria: * patients with pvc who have performed ecg, holter ecg and a cmr exclusion criteria: * patient showing opposition tu use his personal data for the reseach, * patient unable to express his opposition, * patient deprived of liberty, * patient with language issues (speaking or writing french)

Keywords: premature ventricular complexes ventricular arythmias cardiac magnetic resonance focal or diffuse fibrosis structural heart disease idiopathic
fetal growth pattern in short stature women

Conditions: Intrauterine Growth Restriction

Summary: women of short stature tend to be classified regarding fetal growth by the same criteria as women of normal and tall stature. the objective of the following study is to evaluate fetal growth patterns parallel to women's height and try to make conclusions regarding possible definitions of subjective intra-uterine growth restriction.

based on a patient registry, women of short stature tend to be classified regarding fetal growth by the same criteria as women of normal and tall stature. the objective of the following study is to evaluate fetal growth patterns parallel to women's height and try to make conclusions regarding possible definitions of subjective intra-uterine growth restriction. informed consent is not required due to the retrospective nature of the study. patient information including medical, obstetric and general background will be collected.

Eligibility criteria:
inclusion criteria: * women under 1.6 meters of height. * singleton pregnancy. * low risk pregnancy. * accurate dating. exclusion criteria: * women over 1.6 meters of height. * multiple pregnancy. * high risk pregnancy.
characterizing spondyloarthritis with 68ga-fapi pet/ct

Conditions: Spondyloarthritis; Axial Spondyloarthritis; Ankylosing Spondylitis

Summary: to evaluate the potential usefulness of 68ga-fapi pet/ct for the diagnosis, inflammation evaluation and prognosis prediction in spondyloarthritis.

spondyloarthritis (spa) is a chronic inflammatory rheumatic disease characterized by inflammatory back pain, enthesitis, dactylitis, and the formation of syndesmophytes, all of which significantly affect a patient's healthy functioning and general quality of life. prevalence of underlying malignancy is high in patients with spa. radiographic sacroiliitis became a crucial finding in the diagnosis and classification of patients. 68ga-fapi has been developed as tracers specific for fibroblast-activation protein (fap), which is overexpressed in activated fibroblasts in various type of cancers and autoimmune diseases, such as rheumatoid arthritis, igg4-related diseases and interstitial lung diseases. recently the investigators have published articles of the application of 68ga-fapi in igg4-related disease and rheumatoid arthritis, which showed it was more sensitive than fdg in detecting a certain type of inflammation. increased 68ga-fapi uptake in ankylosing spondylitis in a patient with rectal cancer has also been reported in a case report, indicating the potential utility of fap-targeted pet/ct imaging for diagnosis and disease assessment in spondyloarthritis. thus, this prospective study is going to investigate utility of 68ga-fapi pet/ct in diagnosis of spondyloarthritis as well as inflammation assessment in joints including the sacroiliac (si) joints, spine and peripheral joints. also, this study aims to investigate potential utility of 68ga-fapi pet/ct in predicting treatment response and disease prognosis such as formation of syndesmophytes and erosive changes.

Eligibility criteria:
inclusion criteria: 1. a diagnosis of spa according to the asas (assessment of spondyloarthritis international society) classification criteria for spa. 2. adult men or women 18 and ≤ 65 years of age at the time of signing the informed consent (icf). 3. participants who were able to provide informed consent (signed by participant or legal representative) and assent according to the guidelines of the clinical research ethics committee. exclusion criteria: 1. pregnancy; 2. breastfeeding; 3. known allergy against fapi; 4. any medical condition that in the opinion of the investigator may significantly interfere with study compliance.

Keywords: spondyloarthritis axial spondyloarthritis ankylosing spondylitis 68ga-fapi
spironolactone and prevention of calcineurin inhibitor toxicity in kidney transplant recipients

Conditions: Kidney Transplant

Summary: the main objective of this study is to assess the effect of spironolactone on interstitial fibrosis in kidney transplant recipients receiving calcineurin inhibitors


Eligibility criteria:
inclusion criteria: * kidney failure * age \> 18 * kidney transplant recipients exclusion criteria: * patients taking angiotensin receptor blockers or inhibitors of the angiotensin reconverting enzyme * kidney transplant performed more than one month from enrollment in the study * hyperkalemia (k\> 5.5 meql)

Keywords: calcineurin inhibitors fibrosis spironolactone focus of the study is to assess if aldosterone blockade has an effect on interstitial fibrosis amongst kidney transplant recipients