metabolic characteristics of a novel common bean product

Conditions: Type 2 Diabetes

Summary: kenya is classified as having three main forms of malnutrition (overweight, anaemia and stunting), exhibiting a double burden of malnutrition nutritional landscape. trends from the 80s to present show that indicators of overweight and obesity, and diabetes in both adult men and women either show no progress or are worsening. it is a chronic inflammatory metabolic disease occurring when the pancreas is unable to produce sufficient amounts of insulin or when the body cannot effectively utilize produced insulin or both. given that t2dm impacts on several aspects of a patient's quality of life, functionality, and health status, finding effective dietary strategies to combat this condition is key. in diabetes patients, low-glycemic index foods rich in dietary fibre, vitamins, and minerals should be encouraged. common beans are an important source of iron and zinc. common beans contain slowly digestible carbohydrates and a high proportion of non-digestible carbohydrates. fibre (soluble and non-soluble) in beans would be beneficial to t2dm patients by reducing macronutrient absorption, satiety increase, increased sensibility to insulin, effects on inflammatory markers and on intestinal microbiota. moreover, they contain several bioactive compounds possessing anti-inflammatory, antioxidant and other biological activity. due to their composition and effects, common beans have attractive properties for t2dm patients. the common bean predominates other legumes in terms of production in africa. the aim of this research is to study the associated glucose, insulin and appetite responses associated with the consumption of a novel common bean product.

type-2 diabetes (t2dm) in kenya is on a rise with about 458,900 people diagnosed in 2017 and a 2.5-fold projected increase by 2030. prevalence of t2dm is 5.8% and 6.2% in men and women. t2dm has an inflammatory disease character and is characterized by hyperglycemia. common beans in t2dm patients could have many health benefits such as modulation of glucose metabolism, reduction of low-density lipoproteins, and satiety. in this research, we develop a food-grade novel common bean product from food-grade ingredients though the application of conventional food processing technologies. we will then assess postprandial insulin, blood glucose and appetite responses associated with consumption of the common bean product in healthy volunteers and t2dm patients. the specific aims of our research are: 1. to assess the glycemic index (gi) of the common bean product in vivo among 10 healthy volunteers. the gi of the product will be measured over a 120 min period starting at the ingestion of the common bean product. participants will be fed with an equi-carbohydrate portion of the common bean product to the reference food (anhydrous glucose powder, 50g or dextrose (glucose monohydrate), 55g). the test food and reference food will be assessed in each subject on separate days with a 1 week period between each study day. 2. to assess the food insulin index (fii) of the common bean product in vivo among 10 healthy volunteers. participants will be fed with iso-caloric (240 kilocalorie) portions of the test food and reference food. 3. to determine glycemic, insulinemic and satiety (appetite) response associated with consumption of the common bean product among t2dm patients. glycemic and insulinemic response will be evaluated over a 120 min period starting at the ingestion of the common bean product. appetite scores will be used to assess the satiety power of the test product. the appetite score will be assessed before and after consumption of test product at time points 0, 15, 30, 45, 60, 90 and 120 minutes using short questionnaire.

Eligibility criteria:
inclusion criteria: * healthy volunteers (incl. criteria) * male or female 18-69 years * no known food allergies or intolerances * no prescription medication (excluding oral contraceptives) known to affect glucose intolerance (e.g. steroids, protease inhibitors, antipsychotics e.t.c.) * t2dm patients (incl. criteria) * male or female aged 18-69 years * previously diagnosed with type 2 diabetes * consenting to participate exclusion criteria: * healthy volunteers (excl. criteria) * known history of diabetes mellitus or use of anti-hyperglycaemic medication or insulin * alcohol or tobacco use in the evening preceding the test * vigorous exercise on the morning of the test * undergone major medical/surgical event needing hospitalization within the preceding 3 months * presence of disease or drug influencing digestion and absorption of medicine * t2dm patients (excl. criteria) * use of prescription medication * history of eating disorders and irregular eating habits * use of tobacco or alcohol * females experiencing menstrual period or adverse premenstrual symptoms

Keywords: phaseolus vulgaris l. glycemic index food insulin index appetite type 2 diabetes