Kornimate/medical-research-clean huggingface dataset:
construction and validation of a risk prediction model for secondary vertebral fracture in patients with osteoporotic vertebral compression fractures after percutaneous vertebroplasty

Conditions: Osteoporotic Vertebral Fracture; Prediction Model

Summary: "retrospectively collecting clinical data from post-pva (percutaneous vertebroplasty) patients, recording incidences of secondary vertebral fractures, and conducting statistical analysis to create a risk prediction model for recurrent fractures."


Eligibility criteria:
inclusion criteria: 1. meets the diagnostic criteria for primary osteoporosis as per the osteoporosis diagnosis and treatment guidelines (2022); 2. no history of high-energy trauma; 3. patient complains of pain in the lumbar region, confirmed by mri showing a newly developed vertebral fracture from t5 to l5 (i.e., mri shows low signal on t1 and high or slightly high signal on t2); 4. has undergone percutaneous vertebroplasty (pva) treatment. exclusion criteria: 1. incomplete imaging or medical record data; 2. history of spinal surgeries other than pva; 3. pre-existing symptoms of spinal cord compression or nerve root injury; 4. patients undergoing pva treatment due to conditions such as tumors, vascular malformations, infections, or symptomatic schmorl's nodes; 5. chronic conditions like kummell's disease or non-union of old fractures; 6. concurrent vertebral burst fractures; 7. diagnosis of central nervous system diseases such as dementia or stroke before or during the follow-up period post-pva procedure; 8. history of violent trauma after pva procedure.
study of some risk factors for developing ra

Conditions: Rheumatoid Arthritis

Summary: introduction rheumatoid arthritis (ra), a chronic autoimmune disease of unknown etiology, .if not managed early , ra can result in irreversible, painful, and disabling joint damage. ra is often diagnosed using predefined criteria that necessitate clinical, laboratory, and radiologic examinations. the prevalence of ra among adults is approximately 1-2% affecting women two to four times more often than men.although ra risk increases with age, it can manifest at any stage of life, including childhood, adolescence, and adulthood.(1-4)( karlson ew, mandl la, hankinson se, grodstein f, karlson ew, mandl la, hankinson se, grodstein f., karlson ew, mandl la, hankinson se, grodstein f, karlson ew, mandl la, hankinson se, grodstein f) to date, a limited number of ra risk or protective factors have been identified, with genetic predisposition to autoimmune response (eg, hla-dr4 gene) and repeated environmental exposures (eg, tobacco smoke) playing a major role.(3)(karlson ew, mandl la, hankinson se, grodstein f) heritability of ra is well-established because the lifetime risk of ra and related autoimmune diseases (namely, systemic lupus erythematosus, ankylosing spondylitis, scleroderma, sjo¨gren's syndrome, and hypothyroidism) increases 1.5 to 3 times in children of women diagnosed with ra.

patients will answer the following the questationnaire: name age gender 1 socio echonomic status (average salary \\year) (education) (job) (residence) 1. body mass index (height\\wt2) 2. disease duration in months. 3. smoking (yes) (no) passive smoker ex smoker 4. reproductive history: * age of menarche.... * menstrual cycle..... regular or not....... p / c * how many pregnancies........ living. * abortion. * patient age at first birth (....). * breast feeding.....(yes).......(no) * use of contraceptives (yes)...pills injections iud (n0)...... * does patient get pregnant during disease?...(yes)......(no)..... does the arthritis improved (...)or got worse (.....) -flared during the purpurium.(yes) ... (no) * age of menupause.... 10 exposure to sun....(yes).....(no) 11 -theraputic history... (newly diagnosed) * (previously diagnosed), * does the patient receiving ttt? (yes) (steroid)....... (nsaids)....... (2nd line drugs) (.methotrexat(....), leflonamide (....) hydroquine(....) (no)........ * the study will include 100 patients fullfilling acr 2010 * patients well subjected to * through clinical examination with emphysis on joints examination * venous blood sampling will withdrawn and the following investigations will be done. * serum vit d level * serum calcium and phosphorus * anti cyclic citrullinated peptide. * esr

Eligibility criteria:
inclusion criteria: * patients with rheumatoid arthritis diagnosed based on american collegue of rheumatology 2010 criteria with no history of vit d therapy exclusion criteria: * patients with rheumatoid arthritis on vit d supplements * patient refusal * patient not fullfill american collegue of rheumatology 2010 citeria for diagnosis pf rheumatoid arthritis
non-cathartic computed tomographic colonography to screen subjects with a family history of colorectal cancer

Conditions: Colorectal Neoplasia

Summary: background: although subjects with first-degree relatives (fdr) with a history of colorectal cancer (crc) are at increased risk for crc, compliance to screening colonoscopy is suboptimal. computed tomographic colonography (ctc) has been recognized as an alternative for crc screening in average risk subjects, but less information is available on its performance in fdrs. aims: to prospectively assess the accuracy of ctc as a screening tool in fdrs using colonoscopy (oc) with segmental unblinding as reference standard. methods: consecutive patients admitted with crc diagnosis (index case, ic) were prospectively evaluated. following the systematic identification of ics with inherited predispositions to crc, ics who agreed to contact their fdrs ≥40 years old were included. available fdrs were invited to undergo non-cathartic ctc, with oc the following day. sensitivity/specificity/ppv/npv of ctc was assessed for detecting subjects with any lesion ≥6 mm, ≥10 mm, and for advanced neoplasia ≥6 mm.


Eligibility criteria:
inclusion criteria: * family history for crc (first degree) * age \>40 years old exclusion criteria: * contraindications to colonoscopy or ct colonography * pregnancy

Keywords: colorectal cancer colorectal neoplasia ct colonography advanced neoplasia colonoscopy family history
pericardial histopathology and covid-19 seropositivity

Conditions: Inflammatory Response; COVID-19; Pericardial Disease

Summary: this prospective study aims to investigate the association between pericardial histopathologic inflammation grades (acute, chronic, or absent) and covid-19 seropositivity in adult patients undergoing first-time isolated coronary artery bypass grafting (cabg). pericardial tissue samples were collected during surgery and evaluated histopathologically, while preoperative covid-19 serological testing was performed. the primary outcome is to determine whether covid-19 seropositivity is associated with the severity of pericardial inflammation. patients with prior cardiac surgery, active covid-19 infection, systemic inflammatory diseases, chronic immunosuppressive therapy, or malignancy were excluded from the study.


Eligibility criteria:
inclusion criteria: * age ≥20 years * undergoing first-time isolated coronary artery bypass grafting (cabg) * availability of pericardial tissue sample for histopathological analysis * preoperative covid-19 serological testing performed * written informed consent obtained exclusion criteria: * previous history of cardiac surgery (e.g., prior cabg, valve surgery) * concomitant cardiac procedures during the same operation (e.g., valve repair, aortic surgery) * active covid-19 infection at the time of surgery (positive pcr test) * known autoimmune or systemic inflammatory diseases (e.g., lupus, rheumatoid arthritis) * chronic immunosuppressive therapy (e.g., steroids, biologics) * known malignancy at the time of surgery insufficient or inadequate pericardial tissue sample for histopathological assessment
hypoxic conditioning in heart failure

Conditions: Heart Failure, Systolic

Summary: heart failure impairs quality of life and exercise capacity, despite an optimal medical therapy. alternative methods, like hypoxic conditioning coupled to exercise training, must be explored and describe

all heart failure patients will have a session of 45' of bicycle exercise training (in normoxia or hypoxia) and a one hour rest session (in normoxia or hypoxia). exercise training sessions will consist in a continue bicycle exercise test at 70 to 80 % of the maximal heart rate, while breathing (single blind) normoxia or hypoxia gaz. rest conditioning consist in a one hour of rest, while breathing (single blind) normoxia or hypoxia gaz. for hypoxia sessions, the oxygen saturation target will be fo 85-90 % for the 4 first weeks and 80-85 % for the last 4 weeks. three arms : * exercise training in normoxia and rest conditioning in normoxia * exercise training in hypoxia and rest conditioning in normoxia * exercise training in normoxia and rest conditioning in hypoxia

Eligibility criteria:
inclusion criteria: * patient available for exercise training * stable heart failure state i-ii new york heart association (nyha) with altered ejection fraction (ef ≤ 40 %) * signed informed consent exclusion criteria: * unstable ischemic cardiopathy * right ventricle dysfunction * uncontrolled arrythmias * rest elevated in pulmonary artery pressure (≥ 45 mmhg) * migraine * high altitude trip above 2500 m high during study period * impossibility to realise a maximal bicycle exercise test

Keywords: hypoxia exercise training heart failure cardiac remodeling
antibody seroprevalence and rate of asymptomatic infections with sars-cov-2 in austrian hospital personnel.

Conditions: Severe Acute Respiratory Syndrome Coronavirus 2; SARS-CoV 2; Coronavirus Infection; Covid19

Summary: context: on march 11, the world health organization (who) announced the current corona virus disease 2019 (covid-19) outbreak as a pandemic. the first laboratory-confirmed case of covid-19 in austria was announced on february 27, 2020. since then, the incidence of infection follows a gradual increase. measurements taken by the austrian government include travel restrictions, closing of national borders, social distancing, a mandatory use of facemasks in public, and closing of stores and restaurants. the underlying aim of those imposed restrictions is to contain the viral transmission and to slow spreading of the severe acute respiratory syndrome coronavirus 2 (sars-cov-2). objectives: the aims of this study are to determine i) how many employees in austrian trauma hospitals and rehabilitation facilities have virus specific igg and igm antibodies against sars-cov-2, ii) how many are active virus carriers (symptomatic and asymptomatic), iii) how many employees are in their incubation period during the study period, and iv) to calculate the sars-cov-2 prevalence together with a specific occupation associated infection risk within the different specifications of health care workers. study design: open uncontrolled observational cross-sectional study. setting/participants: a total of 4000 employees in 11 austrian trauma hospitals and rehabilitation facilities of the austrian social insurance for occupational risks (auva) will be invited to participate in the study. study interventions and measures: an antibody test for sars-cov-2 specific igg and igm antibodies, and a rt-pcr test based on oropharyngeal swab samples, as well as laboratory-based antibody tests using elisa, will be implemented to ensure protection and preservation of health in hospital staff and are not part of the study. the tests will be conducted twice, with approximately two weeks in between testing. the results of the tests will be used for statistical analysis in this study together with a questionnaire including questions related to personal health, traveling activities, living situation, as well as inquiries of symptoms and comorbidities.


Eligibility criteria:
inclusion criteria: * employees in austrian trauma hospitals and rehabilitation facilities of the austrian social insurance for occupational risks (auva) exclusion criteria: * na

Keywords: covid-19 diagnostic testing sars-cov 2 severe acute respiratory syndrome coronavirus 2
efficacy of vitamin e in preventing contrast-induced acute kidney injury following coronary angiography

Conditions: Stable Angina; Unstable Angina; Non ST Segment Elevation Myocardial Infarction; Post MI

Summary: the purpose of this study is to evaluate the effect of vitamin e on preventing from incidence of contrast induced acute kidney injury (ci-aki) in the patients who undergone coronary angiography.


Eligibility criteria:
inclusion criteria: 1. all patients whon have either stable coronary artery disease (cad) or recent acute coronary disease (acs) and are scheduled for coronary angiography. 2. patients who have egfr ≤60 ml/min/1.73 m2 exclusion criteria: 1. allergy to contrast media 2. cardiogenic shock 3. pulmonary edema 4. overt cardiac failure or left ventricular ejection fraction ≤ 30% 5. acute kidney injury 6. the history of receiving contrast media for any medical diagnostic or therapeutic procedures during previous 5 days 7. the history of dialysis 8. being pregnant 9. having recent acute myocardial infarction 10. taking antioxidants and nephrotoxic drugs including nsaid and ace-i on previous 2 days

Keywords: alpha-tocopherol vitamin e contrast-induced acute kidney injury coronary angiography
metabolic phenotypes and heterogeneity in disease burden risk in type 1 diabetes

Conditions: Diabetes Mellitus

Summary: this study focuses on individuals with type 1 diabetes (t1d) and seeks to comprehensively study and understand several aspects of t1d including: susceptibility to hypoglycemia (low blood sugar) and improvement in hypoglycemia risk using of advanced diabetes technologies, such as continuous glucose monitoring (cgm); the differences among individuals with t1d in the risk of chronic complications, and minimize the psychosocial impact of t1d.

the study seeks to comprehensively study and understand several aspects of type 1 diabetes (t1d) including: the risk of low blood sugar and how that may be improved with new technologies; the variability (heterogeneity) among individuals in their risk of diabetes complications, and factors that could impact the psychosocial burdens of having t1d. the investigators want to learn of there are patient-specific systemic metabolomic profiles (substances detected in blood or urine) that lower the risk for hypoglycemia. metabolomic analyses will be used to discover biological markers that could predict who is most likely to get diabetes complications, and how these risks might be changed, for example, by developing treatments targeted specifically to those biological markers. the investigators also plan to describe the relationship between metabolomic profiles, psychosocial states and cognitive function.

Eligibility criteria:
inclusion criteria: * all participants with type 1 diabetes * previous enrollment and participation in the university of michigan t1d cohorts (natural history of myocardial dysfunction in t1d (hum00036408); targeting inflammation with salsalate in a t1d(hum00169353); preventing early renal loss with allopurinol in t1d (hum00080944); and tissue specific metabolic reprogramming (hum00060967)). * willing and able to participate in the study procedures described in the consent form. * willing to sign a written or electronic informed consent, including authorization to release health information. * fluent in spoken and written english. * willing to carry around their mobile phone/study mobile phone during the 14-day home monitoring period with daily access to cellular or wifi connectivity. exclusion criteria: * any social or medical condition that would, in the opinion of the principal investigator (pi), prevent complete participation in the study or would pose significant hazard to the subject's participation. * skin conditions or diseases that would interfere with the continuous glucose monitor (cgm) sensor placement or accuracy (such as extensive psoriasis, extensive eczema, scarring, etc.) * scheduled x-ray, mri, ct scan, or high-frequency electrical heat (diathermy) treatment during the period of cgm wear (or any other activity that would necessitate cgm sensor removal) that cannot be scheduled around or accommodated within the study assessment windows.

Keywords: diabetes type-1 diabetes mellitus endocrinology
phase ii of zactima maintenance for locally advanced or metastatic non-small-cell lung carcinoma (nsclc) following platinum-doublet chemotherapy

Conditions: NSCLC

Summary: this study is multicenter, randomized, double-blinded, placebo-controlled phase ii study comparing vandetanib (300mg daily) plus best supportive care (bsc) to placebo plus bsc as maintenance treatment in patients with locally advanced or metastatic nsclc, who have received and responded to prior platinum-doublet systemic chemotherapy. the primary objective of the study is to compare the progression free survival (pfs) rate at 3 months in locally advanced or metastatic nsclc patients with or without vandetanib maintenance.


Eligibility criteria:
inclusion criteria: * histologic or cytologic confirmation of locally advanced or metastatic nsclc (iiib-iv) at the time of original diagnosis. * completion of 4 cycles of chemotherapy of gemcitabine (1,000 or 1250mg/m\^2/day on day 1 and 8) and cisplatin (70-80mg/m\^2/day on day 1) every 3 weeks and have shown response, complete response(cr), partial response (pr) or stable disease (sd) by recist. * who ps 0-1 * no prior radiotherapy to chest, immunotherapy or biologic therapy exclusion criteria: * mixed small cell and non small-cell lung cancer history. * prior treatment with egfr tkis or vegfr tkis (prior treatment with cetuximab \[erbitux\] or bevacizumab \[avastin\] is not permitted.) * evidence of severe or uncontrolled systemic disease or any concurrent condition which in the investigator's opinion makes it undesirable for the patient to participate in the study or which would jeopardize compliance with the protocol. * radiation therapy within 4 weeks before the start of study therapy. major surgery within 4 weeks, or incomplete healed surgical incision before starting study therapy.

Keywords: vandetanib, nsclc, maintenance, phase ii
effectiveness of physical therapy for pain relief in footballers with muscle injuries: a prospective study

Conditions: Athletic Injuries; Physical Therapies

Summary: the objective of this study was to evaluate the efficacy of cryoultrasound therapy versus diathermy in combination with high-intensity laser therapy for pain relief in male professional soccer players with muscle injuries. the main questions it intends to answer are: • is this combination of treatments effective in these patients in terms of pain relief? participants will receive a rehabilitation treatment consisting of cryo-ultrasound therapy and high intensity laser. researchers will compare the group of participants, called the treatment group, with a control group to see if: • is the combined treatment of cryoultrasound therapy and high intensity laser more effective in these patients than the combination of diathermy and high intensity laser?


Eligibility criteria:
inclusion criteria: * age 18-21 years; * professional footballer in a competitive club; * presence of a grade iii a muscle lesion, according to the mueller-wohlfart classification, confirmed by ultrasound examination and occurring during sports activity at least 5 days before inclusion in the present study; * no previous muscle injuries in the last 6 months; * signature of the written informed consent for participating in the study. exclusion criteria: * previous muscle injuries or bone fractures of the lower limbs in the last 6 months; * knee instability due to previous rupture of knee ligaments; * active neoplastic or infectious diseases; * congenital anomalies of the lower limbs.
medical thoracoscopy for undiagnosed transudative and exudative pleural effusion

Conditions: Medical Thoracoscopy

Summary: indonesia is one of country that contributes the most cases of tuberculosis worldwide. tuberculosis is the most commonly etiology of exudative pleural effusion. there have been many studies about undiagnosed exudative pleural effusion, but there are not many studies about the use of medical thoracoscopy for diagnosing transudative and exudative pleural effusion, especially on biomarkers of c-reactive protein (crp), d-dimer, adenosine deaminase (ada), antinuclear antibody (ana), c3 c4 complements, cancer antigen 125 (ca-125), xpert mycobacterium tuberculosis (xpert mtb), lupus erythematosus cell (le cell), cytology (effusion and smear) and histopathology. information gained from those biomarkers via thoracenthesis and medical troracoscopy, etiology of exudative and transudative pleural effusion can be detected earlier and clearly, especially etiology of infection, autoimmune, and malignancy that further can be used to reduce patients' hospitalization period, mortality, and to develop the new therapeutic agents.

medical thoracoscopy is a minimally invasive procedure to access pleura with combination of visual and medical instrument. the procedure is performed under local anesthesia and conscious sedation. medical thoracoscopy plays role in basic diagnotic and therapeutic. the most common indication on basic diagnostic is on pleural effusion case that has primary target to get specific diagnosis when the etiology of pleural effusion is unknown. pleural effusion is fluid accumulation inside the pleura for about 15-20 ml. primary aim of pleural effusion diagnosis is to differentiate exudative and transudative effusions based on light criteria. most of time thoracentesis cannot give etiology of exudative and transudative pleural effusion. researchers will evaluate subjects based on inclusion and exclusion criteria in cipto mangunkusumo hospital. furtehrmore, research subjects will be asked for informed consent. data will be collected based on research form. researcher will perform medical thoracoscopy to take specimen for analysing crp, d-dimer, ada, ana, c3 c4 complements, xpert mtb, le cell, cytology (effusion and smear) and histopathology to detect the etiology of tuberculosis, malignancy or autoimmune.

Eligibility criteria:
inclusion criteria: * hospitalized adult age 18 - 75 years old * willing to be involved in the research * undiagnosed transudative and exudative pleural effusion post-thoracentesis twice on right and left lung * patients can undergo medical thoracoscopy under local anesthesia, based on ats and bts guideline exclusion criteria: * pregnant and breastfeeding women * patients in non-invasive ventilation and mechanical ventilator * transudative and exudative pleural effusion with etiology of chronic heart failure, chronic kidney disease, hepatocirrhosis with or without hepatic hydrothorax and hypoalbuminemia.