Kornimate/medical-research-clean huggingface dataset:
evaluation of the effectiveness of a protein pulse-feeding pattern in elderly patients

Conditions: Protein-Energy Malnutrition

Summary: the researchers tested the hypothesis that a protein pulse-feeding pattern was more efficient in improving muscle mass and immune functions than was a protein spread-feeding pattern, after 45 days, in elderly malnourished patients.

to estimate the amelioration of the accretion in protein and the immunizing deficit thanks to a nutrition "pulsee" ( to hold on 80 % of the proteic by day in on meal) with a proteic distributed all along the day for old subjects having a denutrition to also estimate that the diminution of the morbidity decrease (infections, bedsores) the average during the stay and the mortality according to 2 modalities of grip nutritional

Eligibility criteria:
inclusion criteria: * must be malnourished * hospitalization into a geriatric rehabilitation care unit * age \> 70 years * c-reactive protein (crp) \< 50 mg/l exclusion criteria: * enteral or parenteral nutrition * renal, cardiac or digestive insufficiency * diabetes * pacemaker * mini-mental state (mms) \< 15

Keywords: protein pulse-feeding nutritional supplementation protein-energy malnutrition elderly subjects body composition
genicular nerve phenol neurolysis versus radiofrequency ablation for pain relief in grade 4 knee osteoarthritis

Conditions: Joint Pain

Summary: the goal of this clinical trial is to compare the efficiency and efficacy of genicular nerves blockade by chemical phenol neurolysis versus radiofrequency ablation in managing pain in patients suffering from grade iv koa in term of nrs pain score. the participants will be evaluated by numeric rating scale and oxford knee score for assessment of pain relief up to 16 weeks.


Eligibility criteria:
inclusion criteria: * grade 4 knee osteoarthritis according to kellgren-lawrence radiological classification. * failure to manage pain with conservative methods. exclusion criteria: * prior knee replacement * patients with cardiac pacemakers or implantable cardiac defibrillators. * septic knee or systemic sepsis. * allergy to any of the drugs used in the study. * coagulopathy or patients on anticoagulants. * patients with psychiatric illness.

Keywords: phenol neurolysis radiofrequency knee osteoarthritis
surrogating physician-recorded score2 risk calculator inputs by using auxiliary data

Conditions: Cardiovascular Diseases; Menopause

Summary: the goal of the clinical trial is to assess whether the data collected from wearable devices can reduce the uncertainty in predicting the cardiovascular disease (cvd) risk in women aged 40-69 years in a situation where information about the blood pressure and blood lipids are unavailable. participants will: * complete a screening and baseline assessment, including blood sample collection and vital parameter measurement. * wear a wearable device for one week. * fill in a work and sleep journal. * complete a last visit assessment.


Eligibility criteria:
inclusion criteria: * fluency in german (written and oral). * ownership of a smartphone. * signing the informed consent form. exclusion criteria: * diagnosis of cardiovascular disease. * diagnosis of diabetes mellitus. * diagnosis of chronic kidney disease. * diagnosis of familial hypercholesterolemia. * incapable of providing informed consent. * current employment at the section gynecological endocrinology and reproductive medicine of the department for obstetrics and gynecology at the inselspital bern or any other professional relation to one of the study project leaders / investigators. * concurrent participation in a clinical intervention study. * inability to comply with the study procedures for any reason, including language comprehension, psychiatric illness, general inability to get to the study site. * participant's smartphone not compatible with fitrockr. * technical inability of participant's smartphone to connect to the smartwatch.

Keywords: menopause cardiovascular disease risk wearables score2 health monitoring
variability in spinopelvic parameters among patients undergoing total hip arthroplasty

Conditions: Osteoarthritis, Hip

Summary: this research is being conducted to assess measurement correlations on different x-ray views on patients who have undergone or will undergo hip reconstruction surgery.


Eligibility criteria:
inclusion criteria: * ability to provide informed consent. * 40 patients: 20 preoperative tha, 20 postoperative tha; * sex: 20 men, 20 women; * age: 20 patients ≥ 70 years, 10 patients 50-70 years, 10 patients 18-50 years. exclusion criteria: - patients with lumbosacral hardware, contralateral tha.
evaluation of prolonged apnea supported by high frequency non-invasive ventilation.

Conditions: Non-invasive Ventilation; High-frequency Ventilation; Healthy Volunteer; Lung Diseases

Summary: the purpose of the study is to assess the efficacy of high-frequency non-invasive ventilation on apnea duration, carbon dioxide clearance and oxygen delivery in healthy subjets and patients with lung disease.

high frequency ventilation (hf-v) allows to ensure oxygen delivery and carbon dioxide clearance despite the absence of thoracic movement in anesthetized, invasively ventilated subjects. this same technique could be applied by a non-invasive interface (hf-niv), allowing to obtain a prolonged apnea (absence of thoraco-abdominal respiratory movements) in awaken subjects. such an application would be of interest for several clinical applications, e.g. lung imaging and radio-therapy treatment on lung cancer. the purpose of the study is to assess the effect of different hf-niv setting on the apnea duration, carbon dioxide clearance and oxygen delivery in healthy subjets and patients with lung diseases.

Eligibility criteria:
inclusion criteria: * healthy subjets : normal respiratory function and no known lung disease * lung disease patients : chronic obstructive pulmonary disease, sarcoidosis, cystic fibrosis * age \>=18y exclusion criteria: * increased pneumothorax risk under positive pressure ventilation * pregnancy
metformin in children and adults with fragile x syndrome

Conditions: Fragile X Syndrome

Summary: fragile x syndrome (fxs) is caused by loss of fmr1 expression on the x chromosome that leads to increased mrna translation, which results in hyperactivation of erk (extracellular signal-regulated kinase) and mtorc1 (mechanistic target of rifampicin complex 1) signalling and consequently in synaptic dysfunction and neurological development. there is presently no cure for fxs. recent studies suggest that metformin (a widely prescribed drug for type ii diabetes in children and adults) which crosses the blood-brain barrier, corrects various neurological and behavioral fxs phenotypes by normalizing erk signaling, eif4e phosphorylation and lowering expression of mmp9 to normal. since this drug has not been previously used specifically for treatment of fxs (only few cases reported), the investigators propose an open-label trial of metformin in children and adults with fxs to better understand the safety and efficacy in both behavior and cognition.


Eligibility criteria:
inclusion criteria: * aged between 10 et 45 years old * bmi \> 18.3 * molecular diagnosis of fxs * accompanied by his legal tutor exclusion criteria: * pregnancy/breastfeeding * intolerance to metformin * history of lactic acidosis * gastric/renal/hepatic pathology * acute medical condition * concomitant use of ace inhibitors * modification of antipsychotic treatments in the last 6 weeks

Keywords: metformin insulin signalisation
insulin resistance and central nervous system (cns) function in type 2 diabetes

Conditions: Insulin Resistance; Type 2 Diabetes Mellitus

Summary: the purpose of this study is to examine the effects of treating insulin resistance on memory and attention, brain glucose utilization, and proteins in spinal fluid.

insulin resistant conditions such as impaired glucose tolerance, type 2 diabetes mellitus, and hyperinsulinemia have been associated with an increased risk for memory decline and for alzheimer's disease. the main study will determine whether treatment with pioglitazone or nateglinide will improve verbal memory and selective attention for older adults with impaired glucose tolerance or mild type 2 diabetes. the main study will also characterize changes in blood concentrations of insulin, inflammatory markers, and the beta-amyloid peptides that are related to alzheimer's disease. in one sub-study, participants will undergo brain positron emission tomography (pet) imaging before and after 16 weeks of treatment with pioglitazone, nateglinide, or placebo. the purpose of this sub-study is to determine the effects of treatment on brain glucose utilization. in a second sub-study, participants will undergo a lumbar puncture procedure before and after treatment. the purpose of this sub-study is to determine the effects of treatment on spinal fluid concentrations of insulin, inflammatory markers, and beta-amyloid peptides. together these main and sub-studies should characterize the effects of insulin resistance on cognition and suggest a mechanism by which insulin resistant conditions increase risk for memory decline and for alzheimer's disease.

Eligibility criteria:
inclusion criteria: * impaired glucose tolerance or mild type 2 diabetes mellitus or normal blood sugar regulation * stable weight and activity level exclusion criteria: * medications for diabetes * dementia * medications with known effects on memory * serious neurologic disease or head trauma * serious systemic illness (e.g., renal failure or uncontrolled hypertension) * serious psychiatric illness (e.g., schizophrenia or bipolar disorder) * allergy to pioglitazone or nateglinide

Keywords: impaired glucose tolerance
detection of residual disease in children receiving therapy for acute myeloid leukemia or myelodysplastic syndrome

Conditions: Leukemia; Myelodysplastic Syndromes

Summary: rationale: diagnostic procedures may improve the ability to detect residual disease. purpose: clinical trial to detect the presence of residual disease in children who are receiving therapy for acute myeloid leukemia or myelodysplastic syndrome.

objectives: i. determine the frequency and prognostic significance of persistent abnormal cells with an aberrant phenotype detected by multidimensional flow cytometry (mdf) in bone marrow samples from children who have achieved clinical remission after receiving treatment for acute myeloid leukemia or myelodysplastic syndrome. ii. compare the frequency of persistent abnormal cells obtained by mdf with that of polymerase chain reaction (pcr), morphologic, and cytogenetic analyses of these patient samples. iii. determine the frequency and prognostic significance of persistent abnormal cells with a leukemia-specific molecular marker detected by pcr in samples from these patients. outline: patients have bone marrow samples collected during the course of therapy on the ccg 2961 acute myeloid leukemia treatment protocol. these samples are collected: 1. at the time of diagnosis 2. at the end of induction (within a week of day 35) 3. at the end of consolidation (before bone marrow transplant or capizzi 2) 4. before and after interleukin-2 (il-2) therapy, if applicable 5. at the end of therapy (after transplant with evidence of engraftment for autologous bone marrow transplant patients; after course 2 of intensification for chemotherapy patients; and after il-2 day 21 for il-2 patients) 6. at relapse, if applicable. the presence of minimal residual disease in bone marrow is assessed using multidimensional flow cytometry and pcr. projected accrual: a total of 400 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: acute myeloid leukemia (aml) or myelodysplastic syndrome and enrolled on the ccg 2961 aml treatment protocol must have one of the following cytogenetic abnormalities t(8;21) inv(16) abnormality of 11q23 or all patients being enrolled for interleukin-2 therapy or standard care can be enrolled at the time of randomization patient characteristics: age: children performance status: specified on the ccg 2961 aml treatment protocol life expectancy: specified on the ccg 2961 aml treatment protocol hematopoietic: specified on the ccg 2961 aml treatment protocol hepatic: specified on the ccg 2961 aml treatment protocol renal: specified on the ccg 2961 aml treatment protocol prior concurrent therapy: specified on the ccg 2961 aml treatment protocols

Keywords: recurrent childhood acute myeloid leukemia untreated childhood acute myeloid leukemia and other myeloid malignancies de novo myelodysplastic syndromes previously treated myelodysplastic syndromes secondary myelodysplastic syndromes
safety and efficacy of s-8184 in second line treatment of stage iii or iv colorectal adenocarcinoma

Conditions: Colorectal Adenocarcinoma

Summary: phase iia, multicenter, dose escalation study evaluating the safety and efficacy of weekly s-8184 paclitaxel injectable emulsion in second line treatment of patients with stage iii or iv colorectal adenocarcinoma.

the goals of this study are to determine the objective response rate, to determine time to disease progression, duration of response, and survival, and to identify the maximum tolerated weekly dose and principal toxicities of s-8184 in this patient population.

Eligibility criteria:
inclusion criteria: histologic diagnosis of colorectal adenocarcinoma stage iii or iv (dukes's stage c or d) one and only one prior cytotoxic chemotherapy regimen which must have included 5-fu adult (18 years of age or older) patients adequate hematologic function (anc greater than 1500 cells/mm3 and platelets greater than 100,000/mm3) serum creatinine less than 2.0 mg/dl total bilirubin less than 1.5 mg/dl; sgot and sgpt less than 3 times the upper limit of institutional normal values ecog performance status of 0 - 2 bidimensional measurable disease patients who have signed an irb / ethics committee approved informed consent life expectancy at least 12 weeks patient has fully recovered from any previous surgery (at least 4 weeks since major surgery) patient has a negative pregnancy test prior to study entry if premenopausal. (patients of child bearing potential must use a medically effective form of contraception during the treatment.) exclusion criteria: patients who have received any taxane-containing preparation including taxol (paclitaxel) or taxotere (docetaxel) females who are pregnant or lactating patients with peripheral neuropathy nci-ctc grade 2 or greater patients who have received wide-field radiation, cytotoxic chemotherapy or hormonal therapy within 4 weeks of study entry; or mitomycin or nitrosoureas within 6 weeks of study entry patients who have had an investigational agent within 4 weeks of study entry patients receiving concurrent anticonvulsants known to induce p450 isoenzymes
respiratory mechanics in brain injured patients

Conditions: Brain Injury; Acute Lung Injury

Summary: the hypothesis is that brain injury patients have alterations of the respiratory system related to intraabdominal pressure. furthermore application of moderate levels of peep may improve respiratory function in these patients.

we investigate the mechanical properties of the respiratory system, partitioned into its lung and chest wall components, the functional residual capacity, the gas-exchange and alveolar recruitment in brain injured patients. the measurements will be performed under sedation at different levels of peep. the following groups will be included: a) control patients withot lung injury and brain injury; b) brain injured patients without lung injury within the first 72 hours; c) brain injured patients without lung injury after 72 hours; d) brain injured patients with lung injury. brain injury was defined as primary or secondary. respiratory functional data will be related to intra-abdominal pressure.

Eligibility criteria:
inclusion criteria: * male and female * age \> 18 yrs * mechanical ventilation * no smoker * no lung injury at entry * brain injury (traumatic or postoperative or spontaneous bleeding) in brain injury group exclusion criteria: * pregnancy * hemodynamic instability * immunodepression

Keywords: intraabdominal pressure
acute effects of autoregulated and non-autoregulated blood flow restrictive exercise on indices of arterial stiffness

Conditions: Arterial Stiffness; Healthy Lifestyle

Summary: to investigate the acute effects of autoregulated (ar) and non-autoregulated (nar) bfr exercise on indices of arterial stiffness. ar bfr training devices adjust pressure in the cuff ensuring similar pressure throughout the range of motion when the muscles are contracted (dilatated) and relaxed. nar bfr training devices do not adjust pressure in the cuff throughout the range of motion when the muscles are contracted and relaxed which cause greater pressures at different points in the range of motion. methods: following a randomized ar or nar familiarization training session, 20 adults (23±5 years; 7 female) participated in 3 randomized treatment-order sessions with ar-bfr, nar-bfr, and no- bfr separated by 1-week washout periods. participants performed 4 sets of dumbbell wall squats to failure using 20% of 1 repetition maximum (1-rm) at 2-second concentric/eccentric cadence. training limb occlusion pressure (lop) was set at 60% of supine lop for both the at and nar sessions. testing before and immediately following the training session included ultrasonography of the carotid artery, applanation tonometry, and blood pressure acquisition. two-way anovas were used to examine the effects of treatment and the treatment-order interaction on pulse wave velocity (pwv), beta-stiffness index (β-stiff), and arterial compliance (ac). results: there were no baseline differences in cf- (carotid-femoral) pwv, cr- (carotid-radial) pwv, β-stiff, and ac (all p \> 0.05). cf-pwv increased in the nar-bfr (mean difference = 0.57±1.12 m/s, p = 0.02) and no-bfr (mean difference = 0.63±1.42 m/s, p = 0.03) groups following the exercise session. cr-pwv increased in the no-bfr (mean difference = 0.82±1.5 m/s, p = 0.03) group. and there was an interaction effect in cfpwv between ar-bfr and nar-bfr (mean difference = 0.70±1.6 m/s, p = 0.03). conclusion: these findings show acute ar-bfr training does not influence indices of arterial stiffness while acute nar-brf training increases central stiffness.


Eligibility criteria:
inclusion criteria: 1. age 18-40 years old 2. physically active (\> 6 months of consistent exercise training) 3. weight stable for previous 6 months (+/-2.5 kg) 4. female subjects only- reported regular menstrual cycles for the last 2 years exclusion criteria: 1. bp\>140/90 mmhg 2. bmi\>40 kg/m2 3. diabetes 4. familial hypercholesterolemia 5. past or current history of chd, stroke or major cvd events. respiratory diseases (not including asthma), endocrine or metabolic, neurological, or hematological disorders that would compromise the study or the health of the subject. 6. women must not be pregnant, plan to become pregnant during the study, or be nursing 7. active renal or liver disease 8. all medications and supplements that influence dependent variables 9. recent surgery \< 2 months 10. alcohol abuse 11. sleep apnea 12. claustrophobia
retrospective comparative study of routine lower neck ct in the staging and diagnosis of lung cancer across two cohorts

Conditions: Lung Cancer; Supraclavicular Lymphadenopathy

Summary: this is a study comparing routine inclusion of the lower neck in initial ct thorax in patients with suspected lung cancer to not including it. the study aims to assess whether such an intervention reduces the number of invasive investigations required to achieve a final diagnosis and clinical stage and whether it improves the detection of cervical lymph nodes involvement by lung cancer.

two practices currently exist regarding the role of lower neck ct in patients with suspected lung cancer but with little evidence for either. routine lower neck ct is potentially associated with benefits of higher detection of neck lymphadenopathy leading to better staging, less invasive procedure with positive implications for patients experience and care. the potential harms are delay in diagnosis due to false positive findings and radiation exposure. there is limited evidence in this area so this study will potentially provide evidence to inform health policy decisions based on the risk benefit balance. this is a retrospective comparative study to assess the real-life impact of routine lower neck ct on the diagnostic and staging work up of patients with suspected lung cancer across two cohorts.

Eligibility criteria:
inclusion criteria: * male or female age \> 18 years * pathologically confirmed primary lung cancer * intrathoracic n2 and or n3 disease on ct defined as lymph node with short diameter \> 10 mm exclusion criteria: * none
modelling of correlation between emergency department admissions and location-specific air quality and weather in the florence urban area

Conditions: Emergency Service, Hospital; Air Pollution; Weather

Summary: the goal of this observational study is to evaluate the impact of primary air pollutants and weather parameters on emergency department (ed) visits in the metropolitan area of florence.

this is a retrospective, single-center, observational cohort study aimed at investigate the impact of primary air pollutant concentrations and weather parameters on emergency department (ed) visits in the metropolitan area of florence. anonymous data for each individual ed visit is retrieved from the hospital medical record. the daily concentrations of pm2.5, pm10, no2, so2 and o3 and the levels of atmospheric pressure, humidity and temperature are recorded by stations of the dedicated local agencies. the relationship between ed daily visits and pollutant concentrations or weather parameters are investigated.

Eligibility criteria:
inclusion criteria: * consecutive emergency department visits within the study period exclusion criteria: * patients resident outside the metropolitan area investigated * patients admitted to the emergency department for traumatic injuries
injury risk factors in volleyball players

Conditions: Injury;Sports; Athletic Injuries

Summary: the aim of this study is to examine the relationship between injury risk and pain, fatigue, muscle strength, balance and quality of life in volleyball players. in this context, it will be investigated how the pain and fatigue levels experienced by volleyball players interact with muscle strength and balance and how these factors increase the risk of injury.

musculoskeletal injuries are highly prevalent among volleyball players and this may be due to the interaction of various physical and subjective factors. although some risk factors such as muscle strength and balance have been previously investigated, there is limited data on how these parameters together relate to injury risk and athlete health. in this cross-sectional study, standardized tests and self-report questionnaires will be administered to a sample of competitive volleyball players.

Eligibility criteria:
inclusion criteria: * be over 18 years old and volunteer * have not had any upper or lower extremity injuries in the last 3 months * have not had any upper or lower extremity surgery in the last 6 months * play volleyball professionally exclusion criteria: * having had a lower or upper extremity injury in the last 3 months * having had upper or lower extremity surgery in the last 6 months * being pregnant

Keywords: pain fatigue muscle strength balance quality of life volleyball sport injury