Kornimate/medical-research-clean huggingface dataset:
tele-rehabilitative exercise training program in nurses with long covid

Conditions: Cardiorespiratory Fitness; Exercise; Long COVID; Nurses; Quality of Life (QOL); Fatigue; Stress; Tele-rehabilitation

Summary: long covid can cause a decline in cardiorespiratory fitness, resulting in fatigue and negative impacts on individuals' quality of life (qol), particularly in nurses who play a crucial role in public health. combining with reduced cardiorespiratory fitness and suffering from a spectrum of long-covid symptoms might substantially exaggertate fatigue, perceived stress, and reduce willingness to work for hospital nurses. therefore, this study aimed to evaluate the effectiveness of tele-rehabilitative exercise on fatigue, perceived stress, symptom severity of long covid, and qol in this population.

the intervention is an extra 8-week tele-rehabilitative exercise program (3 aerobic and 2 strengthing exercise sessions/week at a moderate intensity, 30 min/session), monitored through a wearable devices and a mobile app. the evaluation of the rehabilitation results can be presented as a data chart, and the treatment effects are also clearly presented. outcome measures were assessed at baseline, 4, and 8 weeks. cardiorespiratory fitness was measured before and after the intervention via cardiopulmonary exercise tests.

Eligibility criteria:
inclusion criteria: * nurses older than 20 years of age * have reported a positive result on a covid-19 rapid test or nucleic acid test * one or more of the following symptoms for more than four weeks: fatigue, discomfort after physical or mental exertion, fever, cardiopulmonary symptoms such as difficulty breathing or shortness of breath, cough, chest pain, or palpitations (cdc, 2022) * able to perform activities independently without assistance * total score of 36 or higher on the fatigue severity scale (fss), confirming fatigue symptoms, and report that these symptoms either appeared after the infection or worsened following the infection exclusion criteria: * without the equipment to install a mobile application (app) * unsuitable for wearing devices due to any leg diseases * unable to engage in aerobic or strength training due to neurological or musculoskeletal disorders * pregnancy * cancer * absolute and relative contraindications for cardiopulmonary testing or exercise training * unsuitable for participation in this study by a rehabilitation specialist; * regular exercisers
effect of trunatomy and hyflex edm instrumentation on postoperative pain

Conditions: Endodontically Treated Teeth

Summary: the aim of the present study is to clinically compare the incidence of postoperative pain after root canal preparation using trunatomy system and hyflex electrical discharge machined (edm) rotary system in asymptomatic necrotic mandibular molars.

up till now, there are no clinical studies on the effect of instrumentation using trunatomy files on post-operative pain. furthermore, these newly introduced files can provide more affordable means for instrumentation. therefore, the purpose of this study is to clinically compare the effect of using trunatomy files and hyflex edm files on post-operative pain.

Eligibility criteria:
inclusion criteria: 1. age between 25 - 45 years old. 2. males or females. 3. mandibular molar teeth with: * no pain. * no response to pulp testing. * radiographic appearance with or without a periapical radiolucency. exclusion criteria: 1. patients with pre-operative pain. 2. patients having significant systemic disorders. 3. patients who are allergic to non-steroidal anti-inflammatory drugs. 4. patients with two or more adjacent teeth requiring root canal therapy. 5. teeth that have: * vital pulp tissues. * association with swelling or fistulous tract. * acute or chronic peri-apical abscess. * greater than grade i mobility. * pocket depth greater than 5mm. * no possible restorability. * previous endodontic treatment.
effect of mediterranean diet in obese adolescents with nonalcoholic fatty liver disease

Conditions: Nonalcoholic Fatty Liver Disease

Summary: the aim of this study was to evaluate the effects of mediterranean and low-fat diet on hepatic fat, inflammation markers and oxidative stress in adolescents with nonalcoholic fatty liver disease. this randomized, single-blind controlled study conducted with obese adolescents aged 11-18 years who were admitted to tepecik training and research hospital pediatric gastroenterology outpatient clinic with the diagnosis of nonalcoholic fatty liver disease. participants were randomly assigned to the mediterranean diet or low-fat diet group.

this study was conducted to evaluate the effect of mediterranean and low-fat diet on hepatic fat, inflammation and oxidative stress in obese adolescents with nonalcoholic fatty liver disease (nafld). the study, which was designed as a single blind randomized control, was completed with 44 obese adolescents diagnosed with nafld between the ages of 11-18. adolescents were randomized to either a mediterranean diet (n = 22) or a low-fat diet (control diet) (n = 22) for 12 weeks. at the beginning of the study and at the 12th week, adolescents' blood samples, physical activity and food consumption records were taken, anthropometric measurements and body composition analyzes were made, and antioxidant food consumption frequency and mediterranean diet quality index questionnaire were applied to adolescents. in the controls performed at the 2th, 4th, 6th, 8th, and 10th weeks, the physical activity and food consumption records of the adolescents were repeated and anthropometric measurements and body composition analyzes were made again.

Eligibility criteria:
inclusion criteria: * being between the ages of 11-18 * being obese (bmi ≥95.persentil) * getting a diagnosis of grade≥1 nafld exclusion criteria: * existence of liver disease (wilson,hepatitis etc.) other than nafld * drinking alcohol * having a history of type 1 and type 2 diabetes * using drugs that can cause steatosis * using lipid-lowering drugs * using weight loss medications * having applied dietary therapy for any disease and weight loss * existence of a chronic inflammatory disease * existence of cancer * thyroid dysfunction (hyperthyroid and hypothyroidism) * existence of a history of hepatic virus infection * having a history of parenteral nutrition * being pregnant and breastfeeding * receiving antibiotic treatment within 3 months prior to the study * regularly consuming foods containing probiotic and prebiotic properties and / or using nutritional supplements
perception of children with visible untreated and treated caries

Conditions: Dental Caries

Summary: in germany about 5 to 20% of children suffer from early childhood caries (ecc). preceding results of eye-tracking-studies on the perception of patients with unilateral cleft and patients with severe orthognathic malocclusion let us assume that caries and missing teeth might influence the observer's focus. the aim of this study is to test the hypothesis that the faces of patients with ecc and patients with signs of dental treatment (crown, gap etc.) are contemplated differently from and assessed more negatively than healthy patients. particular attention should be paid to potential differences between the findings of the two observer-groups (medical laypersons/ dental students).

in germany about 5 to 20% of children suffer from early childhood caries (ecc). resulting in complications like damages of the permanent teeth, pain and developmental disorder of the affected jaw, ecc might additionally lead to social exclusion. previous eye-tracking-studies about the perception of patients with unilateral cleft and patients with severe orthognathic malocclusion demonstrated that these variations are transferring the observer's focus from the eyes and nose to the affected region. the aim of this study is to test the hypothesis that the faces of patients with ecc and patients with signs of dental treatment (crown, gap etc.) are contemplated differently from and assessed more negatively than healthy patients. particular attention should be paid to potential differences between the findings of the two observer-groups (medical laypersons/ dental students).

Eligibility criteria:
inclusion criteria: * healthy * student of the university of göttingen or hildesheim * age ≥ 18 years * people who agreed to participate in the study * right-hander exclusion criteria: * missing agreement to participate in the study * missing cooperation, * age \< 18 years * left-hander * wearer of glasses * people with severe systemic diseases, especially states with associated temporary or permanent restriction of immune status * people with severe mental illness who have altered perception or neurophysiological stimulus processing. * people who take regularly or at the time of the study drug or drugs that altered a perception or neurophysiological stimulus processing

Keywords: early childhood caries eye-tracking children dentistry face perception
postoperative pain after the removal of root canal filling material

Conditions: Postoperative Pain

Summary: the aim of this study was to evaluate the intensity and duration of postoperative pain after the removal of root canal filling material in retreatment procedures of upper incisor teeth with chronic apical periodontitis, using different techniques. the patients were assigned to three groups of 45 patients, according to the method used to remove old canal filling material. the presence of postoperative pain was assessed after 6, 12, 24, 48, and 72 hours, 7 days, and finally after 10 days. the hypothesis of this study: there would be no difference in postoperative pain intensity among the groups.


Eligibility criteria:
inclusion criteria: * asymptomatic incisor teeth with chronic apical periodontitis * patients between 18-55 years of age exclusion criteria: * patients with systemic disease

Keywords: intensity
study on the treatment with water-filtered infrared-a (wira) radiation in patients with morphea and sclerotic graft-versus-host disease

Conditions: Morphea (Circumscribed Scleroderma); Sclerotic Graft-versus-host Disease (GVHD)

Summary: this is a prospective, intra-individual comparative study to evaluate the effectiveness of local-water filtered infrared-a (wira) irradiation (applied by hydrosun® radiator 750 for radiation at the clinic, or hydrosun® 575home for home treatment) in patients with morphea or sclerotic gvhd (graft-versus-host disease). the purpose of the study is to determine whether wira irradiation can reduce fibrotic skin alterations in circumscribed scleroderma (morphea) or chronic graft versus host disease. wira irradiation is applied for 30 minutes 3 times per week for 20 weeks to a diseased skin area and a lesional skin on contralateral body site remains untreated. a total of 22 patients (20 evaluable patients with an expected drop-out rate of 10%) are to be included in this study. group a: 11 patients with plaque morphea group b: 11 patients with sclerotic gvhd.

a sclerotic plaque or area of skin on the right side of the body and contralaterally on the left half of the body (each maximum size: 25 cm in diameter, corresponding to the radiation field of the hydrosun® heater 750) is selected. the assignment of one side of the body to irradiation or non-irradiation is randomized (using the meduni graz randomizer). the plaque randomized for irradiation is irradiated on 3 days a week for 30 minutes each time. the treatment period extends over 20 weeks, the total number of radiation treatments is therefore 60. if the patients cannot come to the radiation treatment, home therapy can be carried out according to the same treatment scheme. the radiation at the clinic is carried out with a hydrosun® lamp 750, the home treatment with the hydrosun® 575home (hydrosun medizintechnik gmbh, mauchener str. 14, d-79379 muellheim, germany). the radiation intensity at the distance of 33 cm between the device and the skin surface standardized by a distance rod is 200 mw / cm2 (visible light 50 mw / cm2, infrared a 150 mw / m2). the contralateral plaque or skin area of comparable clinical characteristics and duration of existence was included as an unirradiated control. target and control areas will be photo-documented in the course of the study. before the first irradiation, after the 30th and after the 60th irradiation, the skin thickness and hardness of the target and control regions are measured by a blinded examiner and the skin status including mrss (rodnan skin score) is recorded. in addition, at the beginning and at the end of the study, the patient's assessment of the effect (pgic scale) and tolerability of the therapy is asked. any side effects of the irradiation are continuously documented.

Eligibility criteria:
inclusion criteria: * morphea * sclerotic graft-versus-host disease (gvhd) exclusion criteria: * inability to cope with the treatment plan * pregnant or breastfeeding women and women of childbearing potential without effective contraception
the effect of adalimumab plus methotrexate (mtx) versus placebo plus mtx on cartilage in (ra) patients

Conditions: Rheumatoid Arthritis

Summary: this study aims to compare longitudinally the effect of adalimumab plus methotrexate (mtx) versus mtx monotherapy on cartilage gag content, reflected by delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dgemric) index, in patients with early progressive rheumatoid arthritis (ra), who had not previously received any disease modifying antirheumatic drug (dmard) or biologic treatment.

patients will be randomly assigned to either adalimumab q2w plus oral mtx qw combination therapy or oral mtx qw monotherapy plus placebo subcutaneous (sc) q2w in a ration 2:1. to maintain blinding, matching placebo sc injections will be dispensed q2w to the mtx monotherapy group. all subjects will receive open-label mtx 15 mg qw as oral tablets. all subjects will take approximately 5 mg weekly dietary supplement of oral folate throughout the study on any day beginning 48 hours after ingestion of their oral study medication. defined as standard therapy oral folate supplementation will be taken in a single dose 24-48 h after mtx therapy.

Eligibility criteria:
inclusion criteria: * subject has a diagnosis of early ra (era) fulfilling the 2010 american college of rheumatology (acr) criteria for classification of ra * disease duration less than 12 months from symptoms onset. exclusion criteria: * subject has previous exposure to any systemic biologic therapy (e.g. abatacept, tocilizumab) including anti-tumor necrosis factor (tnf therapy) (e.g., infliximab, golimumab, certolizumab pegol, etanercept) including adalimumab.

Keywords: rheumatoid arthritis
treatment of intimate partner violence and substance abuse in a substance abuse treatment facility

Conditions: Domestic Violence; Substance Abuse

Summary: intimate partner violence is a significant societal problem. there is considerable evidence that a strong relationship between the use of alcohol and other drugs and intimate partner violence exists. besides, a few studies indicate that reducing substance use may have a positive impact on ipv. therefore, in this study, patients in substance abuse treatment for the use of alcohol, cannabis or cocaine who also admit to perpetrating intimate partner violence will be randomly assigned to either cognitive behavioral therapy addressing substance abuse combined with treatment for offenders of intimate partner violence or substance abuse treatment alone.

intimate partner violence is a significant societal problem. however, treatment of ipv perpetrators is far from effective, which may be partly due to the fact that the role of substance abuse is not taken into account. there is considerable evidence that a strong relationship between the use of alcohol and other drugs and intimate partner violence exists. besides, a few studies indicate that reducing substance use may have a positive impact on ipv. therefore, in this study, patients in substance abuse treatment for the use of alcohol, cannabis or cocaine who also admit to perpetrating intimate partner violence will be randomly assigned to either cognitive behavioral therapy addressing substance abuse combined with treatment for offenders of intimate partner violence or substance abuse treatment alone.

Eligibility criteria:
inclusion criteria: * perpetration of intimate partner violence in the past year * substance abuse or dependence (current) * currently in a relationship exclusion criteria: * not sufficient fluency in dutch to complete treatment and measures * (ab)use of crack cocaine and/or heroin * psychosis * psychopathy

Keywords: intimate partner violence domestic violence alcohol abuse alcohol dependence drug abuse drug dependence addiction
evaluating a youth-focused economic empowerment approach to hiv treatment adherence

Conditions: HIV

Summary: the goal of suubi+adherence is to examine the impact and cost associated with an innovative intervention to increase adherence to hiv treatment for hiv-infected adolescents. multiple intervention studies by our team in rakai and masaka districts of southern uganda with aids-orphaned adolescents have revealed that if given an opportunity to participate in economic empowerment interventions, youth and their caregivers take full advantage of these interventions to save and invest in their future, show improvements in family financial outcomes, future aspirations, health functioning, sexual-risk taking behaviors, and mental health. the suubi+adherence study capitalizes on this prior work, positing that economic empowerment may be a missing, yet critical ingredient to hiv treatment adherence interventions for adolescents and young people. suubi+adherence incorporates an economic empowerment design, with a savings-led income generating component, to promote economic stability, and apply it to adherence to hiv treatment regimens for hiv-positive adolescents in a region of southern uganda with the highest hiv incidence and prevalence in the country.


Eligibility criteria:
inclusion criteria: * hiv-positive adolescents confirmed by medical report * prescribed antiretroviral therapy * enrolled in care at one of 40 medical clinics within study region * 10-16 years of age at the time of enrollment * living within a family (not necessarily with biological parent(s)) exclusion criteria: * not hiv-positive * hiv-positive but not prescribed antiretroviral therapy * not enrolled in care at one of 40 medical clinics within study region * younger than 10 years and older than 16 years * not living within a family

Keywords: suubi adolescents poverty economic empowerment interventions adherence to hiv antiretroviral therapy wisepill hiv/aids infected children medical event monitoring system uganda
patient education following a stroke

Conditions: Stroke

Summary: the rapid diagnosis and treatment of acute ischemic stroke are critical in the reduction of morbidity, disability and stroke associated mortality under-education about stroke may prevent people from recognizing symptoms early enough to seek immediate care. the studies reported on stroke patients managed in stroke center have shown that 39-42% of patients could not name any symptoms of stroke and 36% to 43% no risk factor of stroke. the stroke patients are therefore a population at high risk for neurological events and cardiac vascular recurrence. however, no studies have evaluated the interest of the development of therapeutic workshops in stroke unit to educate patients about symptoms suggestive of stroke, risk factors and what to do in cases of stroke. investigators assume that the setting up of a therapeutic education workshop in the stroke unit may allow a better understanding of the symptoms, risk factors and what to do following stroke. so there is a direct benefit to the patient represented by a better knowledge of stroke (warning signs, risk factors, what to do), improved treatment compliance and reduced risk of recurrence. more generally, there is a real benefit to promote these messages to the public through the patient and his relatives


Eligibility criteria:
inclusion criteria: * patients older than 18 years. * diagnosis of ischemic stroke; * patients with back home or shorter rehabilitation; * patients affiliated to a social security scheme; * patients who consented to participate in writing. exclusion criteria: * patients with cognitive disorders, vigilance, aphasia. * patients institutionalized.
gastric bypass with different lengths of the bilipancreatic limb

Conditions: Laparoscopic-Roux-en-Y Gastric Bypass; Obesity; Diabetes Mellitus, Type 2; Hypertension; Dyslipidemias; Sleep Apnea

Summary: laparoscopic roux-en-y gastric bypass (lrygb) has been the most performed bariatric surgical intervention until a few years ago, due to its good results in terms of weight loss and remission of comorbidities such as hypertension, type 2 diabetes mellitus, dyslipidemia and obstructive sleep apnea syndrome. however, more than 25% of patients do not obtain the expected result. there is no uniform technique to perform a lrygb, but traditionally it was constructed using a long alimentary limb (al) and a short biliopancreatic limb (bpl). there is no current consensus on the ideal length of the lrygb limbs. the distal gastric bypass at the expense of a longer biliopancreatic limb (lbpl-gb) could induce more excess of weight loss (ewl%), but with possible protein malnutrition depending on the length of the remaining common limb. the aim of this study is compare a lbpl-gb (bpl 150cm, al 70cm) with lal-gb (bpl 70cm, al 150cm). primary outcome: to evaluate if there are differences in weight loss. secondary outcome: to assess whether there are differences in both groups in remission of the most common comorbidities and in quality of life. design: multicenter, prospective, randomized study in blocks (1:1), blinded for the patient and to the surgeon up to the time of intervention, in patients with indication of rygb for obesity (bmi\>35 with associated comorbidity or bmi\>40 with or without comorbidity, excluding those of bmi\>50). intervention: lrygb type 1 (lal-gb: 150cm aland 70cm bpl) or type 2 (lbpl-gb: 70cm al and 150cm bpl). the expected result is that the patients with lbpl-gb present better ewl%, and higher remission of their comorbidities than the comparison group


Eligibility criteria:
inclusion criteria: * patients with bmi 35-40 kg/m2 with associated medical problems (diabetes mellitus, hipertension, dyslipidemia, obstructive sleep apnea syndrome) or 40-50 kg/m2 with or without associated medical problems, who comply with the regulatory rules for bariatric surgery in spain (seco and aec) exclusion criteria: * general contraindications to kind of surgery * bmi \> 50 kg/m2 * known drug or alcohol abuse * asa (american society of anesthesiology) physical status classification \> iii * inability to follow the procedures of the study

Keywords: diabetes mellitus, type 2 hypertension dyslipidemia obstructive sleep apnea syndrome quality of life nutritional deficit laparoscopic-roux-en-y-gastric-bypass biliopancreatic limb alimentary limb common limb