Kornimate/medical-research-clean huggingface dataset:
safety study of stem cell transplant to treat limbus insufficiency syndrome

Conditions: Limbus Corneae Insufficiency Syndrome

Summary: the purpose of the study is to determine whether allogenic bone marrow stem cell transplant is safe and effective in the treatment of limbus insufficiency syndrome versus allogenic limbus stem cell transplant.


Eligibility criteria:
inclusion criteria: * male or female older than 18 years. * signed informed consent * negative pregnancy test at inclusion for any potential childbearing female. * compromise of contraceptive method during all trial for any potential childbearing female. * diagnosis of ocular surface failure due to limbus insufficiency syndrome, based in any of the published characteristics as corneal surface neovascularization, loss of corneal transparency, epithelial irregularities, history of punctate keratitis, erosions or repetitive ulcers and presence of symptoms and confirmed by the presence of epithelial phenotype cells assessed with conjunctival impression cytology. * availability for all the scheduled visits during the study exclusion criteria: * uncontrolled systemic disease (e.g. hypertension or diabetes) or any disease that under medical decision might put the patient at risk during the surgery or follow-up examinations or may cause any hazard in data analysis. * active ocular infection in any eye. if the infection can be cured, inclusion can be considered after 30 days of inactive infection since its end. * alterations in lid statics / dynamics or any other pathology (e.g. severe dry eye syndrome) except the one that originated the limbus insufficience that under medical opinion might alter the results. any of these must be corrected 3 months prior to patient inclusion, before reconsidering rescreening. * limbus insufficiency syndrome which has not been previously treated with all medical (not surgical) procedures available. * no availability for all scheduled visits during the study. * any other circumstance under investigator´s opinion that prevents patient inclusion even though normal inclusion and exclusion criteria are met.

Keywords: limbus cornea insufficiency syndrome stem cell transplant
oxaliplatin in esophagus cancer (advanced) 1st line

Conditions: Esophageal Neoplasms

Summary: * to determine the activity and efficacy of the schema specified as dose regimen * to determine the safety and tolerability of the oxaliplatin-cisplatin and 5fu


Eligibility criteria:
inclusion criteria: * ecog 0-1 * patients with histologically proven epidermoid carcinoma or adenocarcinoma of esophagus or stomach, with unresectable or metastatic disease; * no previous treatment with chemotherapy or radiotherapy * measurable lesion (uni or bidimensional) exclusion criteria: * creatinin clearance \<50 ml/min * total bilirubin \>1.5\*uln (upper limit of normal) * ast/alt \> 2.5\*uln * total white blood cell \<1.500.000/ml * platelet count \<100.000.000/ml * symptomatic sensitive peripheral neuropathy * pregnant or breast-feeding women the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
zte mri pulse sequence use for visualization of bone cement, breast biopsy markers

Conditions: Breast Carcinoma

Summary: this study is being done to determine if a clinically available mri sequence called zte imaging better visualizes breast biopsy markers made of bone cement compared to the currently used breast biopsy markers made of metal.

primary objective: i. to demonstrate that clinically available zte imaging allows for better visualization of bone cement breast biopsy markers when compared to conventional breast biopsy markers and pulse sequences. outline: this is an observational study. participants undergo standard of care mri breast imaging with conventional or bone cement breast biopsy markers and complete a questionnaire on study.

Eligibility criteria:
inclusion criteria: * age of 18 or older exclusion criteria: * cardiac pacemaker * implanted cardiac defibrillator * internal pacing wires * cerebral, carotid, or aortic aneurysmal clips * cochlear implants * implanted tissue expanders * claustrophobia * cannot lay prone * pregnant
virtual reality a novel screening and treatment aid in attention deficit disorder

Conditions: ADHD

Summary: using a virtual reality program in screening and treatment of adhd.

virtual reality is a novel program designed to imitate a real classroom environment including various distractions. it includes a head monitor to track eye movements children aged 10-20 years with adhd will use the program with and without methylphenidate(1 mg/kg). their results will be compared to a control group. parental consent will be obtained.

Eligibility criteria:
inclusion criteria: clinical diagnosis of adhd-dsm4 criteria age 10-20 years normal neurological examination iq\>80 exclusion criteria: abnormal neurological status

Keywords: virtual reality adhd methylphenidate
validation of k-dvprs

Conditions: Pain, Postoperative

Summary: this study aimed to validate korean version of defense and veterans pain rating scale for the assessment of postoperative pain.

defense and veterans pain rating scale (dvprs) is translated into the korean version through forward-back translation. the k-dvprs is reviewed by the korean expert and finally verified by the investigator of this study. on a day before surgery, postoperative pain at rest and during cough is investigated using k-dvprs, and k-dvprs supplementary questions and eq-5d-5l are conducted. at 24 hours after surgery, postoperative pain of surgical site at rest and during cough is investigated using nrs and k-dvprs, and k-dvprs supplementary questions and eq-5d-5l are conducted. at this time, to assess the reliability of k-dvprs, postoperative pain of surgical site at rest and during cough is re-investigated using k-dvprs after 30-60 minutes. at 48 hours after surgery, postoperative pain of surgical site at rest and during cough is investigated using nrs and k-dvprs, and k-dvprs supplementary questions and eq-5d-5l are conducted. in order to verify the reliability of the k-dvprs, the internal correlation coefficient (icc) and cronbach's alpha coefficient are calculated to evaluate the test-retest reliability. convergent validity and construction validity are calculated to verify the validity of the k-dvprs. spearman correlation analysis between pain intensity at rest and during cough using nrs and k-dvprs is performed to verify convergent validity. in addition, an inter-item correlation analysis is conducted between pain intensity at rest and during cough using k-dvprs, scores of k-dvprs supplemental questions, pain intensity at rest and during cough using nrs, and eq-5d-5l scores. to verify the construct validity, k-dvprs score is analyzed by age, sex, operation time, and the severity of surgery. finally, the mann-whitney u test is used to compare the difference in postoperative during at rest and during cough evaluated by k-dvprs before and 24 hours after surgery. the difference in postoperative pain between 24 and 48 hours after surgery is also compared in the same way. the evaluation success rates of nrs and k-dvprs are also compared at postoperative 24 and 48 hours.

Eligibility criteria:
inclusion criteria: * patients undergoing elective laparoscopic surgery or robot abdomen surgery (duration ≥ 1 hour) under general anesthesia exclusion criteria: * patients with asa ps ≥ iii * patients with a difficulty to answer postoperative pain-related questions or k-dvprs * patients with red-green color blindness or difficulty distinguishing colors * patients who are inappropriate for this clinical trial based on the investigator's opinionr
volumetric pouch study after laparoscopic sleeve gastrectomy

Conditions: Bariatric Surgery Candidate; Obesity, Morbid

Summary: this study aimed to evaluate laparoscopic sleeve gastrectomy in the treatment of morbidly obese patients pre and post-operatively after 3 months, 6 months, and 1-year follow-up and assess the volumetric changes of the gastric reservoir 1 year after lsg using multi-slice computer tomography.


Eligibility criteria:
inclusion criteria: * bmi of \> 40 kg/m 2 or \> 35 kg/m2 with comorbidities e.g. hypertension and type 2 dm. * all patients failed in supervised conservative management for obesity for at least 2 years. exclusion criteria: * bmi \> 60 * previous bariatric surgery * symptomatic reflux oesophagitis disease, gastric pathology (tumor, active peptic ulcer) * significant psychological disorder, active alcohol or substance abuse * severe eating disorders (bulimia) * severe systemic disease making anesthesia or surgery prohibitively risky (american society of anesthesiologists (asa) class iv

Keywords: laparoscopic sleeve gastrectomy gastric reservoir multi-slice computer tomography
effectiveness of pressure biofeedback therapy and progressive muscle relaxation technique in improving pain and disability among patients with non-specific low back pain

Conditions: Low Back Pain, Mechanical; Chronic Low-back Pain; Mechanical Low Back Pain; Lower Back Pain Chronic; Low Back Pain; CLBP - Chronic Low Back Pain; Pain, Chronic; Pain, Back

Summary: low back pain is common msk disease with prevalence of 60 to 70 percent. patients with low back discomfort are typically treated conservatively by physical therapists. progressive muscles relaxation technique has been shown in several studies to reduce chronic back pain and increase flexibility. pressure biofeedback therapy works on intra abdominal pressure.it helps to alleviate compression on lumbar spine and support the adjacent lumbar spine.the aim of this randomized controlled trial is to determine the effectiveness of pressure biofeedback training (pr.bfb) in combination with progressive muscles relaxation technique (pmr) \& progressive muscles relaxation training alone on pain, disability, rom \& endurance of muscles among nonspecific chronic low back pain patients.

a randomized clinical trial will be carried out in the physical therapy o.p.d of dow hospital karachi. collection of data will commence right after approval of synopsis from dow irb. a sample of 70 nsclbp patients calculated by using mean \& sd of visual analogue scale in abdominal stabilisation training with pr.bfb stabilizer was 2.69 ±0.93 and progressive muscular relaxation vas was 3.863 ±2.03. before being recruited into the experiment, patients will be screened to ensure that they meet the inclusion criteria. pain rating scale and roland-morris questionnaire will be used to gather data after explaining the research goals to patients and obtaining formal consent from them. patients will be divided into 2 interventional groups by simple random sampling, with 35 patients in each group. experimental group will be received pressure bio-feedback therapy in combination with pmr technique and thermotherapy. the control group, on the other hand, will be received a combination of progressive muscle relaxation technique and thermotherapy for non-specific clbp. it will be a 6-weeks intervention plan with 3 sessions per week (40-minutes each). assessor will be blinded to the treatment. roland morris low back pain and disability questionnaire (rmq) and the npr scale will be used as primary outcome measures. secondary outcomes will be determined by modified-modified schober test for assessing lumbar rom \& pressure biofeedback stabilizer unit helps to gauge muscular endurance.

Eligibility criteria:
inclusion criteria: * diagnosed and referred patients with non-specific low back pain for more than 3 months * 30 to 50 years * both genders exclusion criteria: * any surgical history of lumbar spine * infections of the spine, malignancy * disc protrusion * history of spinal fractures

Keywords: pressure biofeedback therapy progressive muscles relaxation technique chronic non-specific low back pain chronic low back pain non specific back pain
utility of trimethoprim-sulfamethoxazole use in skin abscess management

Conditions: Skin Diseases, Infectious

Summary: the purpose of this study is to determine if antibiotics are required in the management of skin abscess following incision and drainage.

this is a double-blind, randomized controlled trial at an urban pediatric emergency department. sample size (162) was based on a threshold equivalence of 7% (α = 0.05, power = 80%). inclusion criteria were: non-toxic, immunocompetent, 3 months to 18 years old, english-speaking patients with clinical or ultrasound identified skin abscesses who were not on antibiotics. patients were block randomized to receive placebo or trimethoprim/sulfamethoxazole following incision and drainage. follow-up was a call at 2-3 days \& a repeat visit or call at 10-14 days. treatment failure was defined as: persistent erythema, tenderness, and/or draining lesions. new lesion was defined as: primary resolution with development of new lesion (furuncle, carbuncle or abscess) at a different location. compliance was evaluated by the return of the study medication or by patient report.

Eligibility criteria:
inclusion criteria: * non-toxic patients * immunocompetent patients * 3 months to 18 years old * english-speaking patients * skin abscesses * not on antibiotics exclusion criteria: * toxic patients * immunocompromising co-morbidities * less than 3 months old or older than 18 years of age * non-english speaking * on antibiotics

Keywords: skin abscess ca-mrsa
characterization of variable marrcha's diary variables as a useful measure

Conditions: Chronic Obstructive Pulmonary Disease

Summary: validate a simple clinical tool to evaluate physical activity (the question "how many minutes does it walk per day?" or equivalent), compared to the rest of the collected physical activity data (proactive questionnaire and objective physical activity data by means of an accelerometer record) in patients with copd.

observational, national and multicenter epidemiological study in adult patients with copd that will take place in the consultations of specialists in pneumology under conditions of usual clinical practice and that will be developed in two visits per patient.

Eligibility criteria:
inclusion criteria: adult patients, ≥ 40 years. * patients diagnosed with copd according to the gold criteria: fev1 / fvc postbronchodilator \<0.70 in a spirometry performed in the last 12 months. * smokers or ex-smokers of ≥10 pack-years. * patients with a minimum age in the diagnosis of copd of at least 6 months. * patients who accept their participation in the study and who have given their informed consent (ic) in writing to participate in it. exclusion criteria: * patients whose clinical history data are not available. * patients unable to understand the study questionnaires. * patients with physical limitation (not caused by the respiratory disease, eg disability, orthopedic limitation, etc.) and / or psychic that prevents the proper conduct of the study. * patients who present a moderate or severe exacerbation of copd in the month prior to inclusion. * patients with other chronic respiratory diseases other than copd (such as cystic fibrosis, bronchiectasis of origin other than copd, neoplasia, pneumonia). * patients with serious cardiovascular or neurological diseases. * hospital admission for any reason in the month prior to inclusion.
cryoprobe biopsy and chronic rejection in lung transplant recipients

Conditions: Lung Transplant Rejection

Summary: the goal of this clinical trial is to evaluate which biopsy collection method helps to better diagnose rejection and relevant pathologic findings in lung transplant recipients. the main questions it aims to answer are: does the 1.1 mm cryoprobe or the biopsy forceps provide better quality samples of lung tissue for detecting rejection in transplant recipients? how much tissue is adequate for lung transplant 1.1 mm cryobiopsy samples as compared to biopsy forceps? which samples received by the pathologist did they find they were most confident to exclude rejection, based on their satisfaction with the samples? which collection method has the least amount of procedural time? researchers will compare lung tissue samples obtained using a 1.1mm cryoprobe and a biopsy forceps during the lung transplant. participants will: be randomly assigned to receive either the cryoprobe or biopsy forceps collection method at the time of biopsy. assessed for any adverse events following the biopsy for up to 30 days after transplant.

the purpose of this 1:1 randomized clinical trial is to compare the histological quality and diagnostic yield of tissue samples acquired using a 1.1 mm cryoprobe with those obtained with biopsy forceps in lung transplant recipients for graft surveillance.

Eligibility criteria:
inclusion criteria * male and female lung transplant recipients age \&gt;18 at the time of informed consent * patients clinically meet indication for post-transplant lung biopsy or planned routine surveillance and have been scheduled for bronchoscopy with transbronchial biopsy. * be willing and able to sign the informed consent. exclusion criteria * patients with known bleeding diathesis * platelet count \&lt;50,000 per μl within 14 days of the biopsy procedure * current use of systemic anticoagulation or antiplatelet therapy without the ability to hold therapy for the recommended amount of time prior to an invasive procedure (aspirin monotherapy is acceptable) * inability or unwillingness to give informed consent or study procedures * pregnant or nursing females, or females who intend to become pregnant * females of child-bearing potential who decline a pregnancy test prior to enrollment * if an investigator does not feel that this study is in the subject's best interest or would be a good fit for the study. * international normalized ratio (inr) \&gt;1.5 * do not resuscitate (dnr) status * do not intubate (dni) status * single lung transplant recipients

Keywords: lung transplant bronchoscopy
the effect of aromatherapy in laparoscopic cholecystectomy patients

Conditions: Cholecystectomy; Aromatherapy

Summary: pain experienced before and after surgery in patients undergoing laparoscopic cholecystectomy adversely affects physiological parameters and sleep quality. this randomized controlled study was conducted to examine the effects of preoperative and postoperative inhalation lavender and geranium essential oil on patients undergoing laparoscopic cholecystectomy on pain, sleep, and physiological parameters. the study was completed with 3 groups and 150 people, namely the geranium oil group (n=50), lavender oil group (n=50) and control group (n=50). the ethics committee approval, informed consent of the individuals and the institutional permission were obtained. in the study, data were collected using the patient identification form, richard-campbell sleep scale and visual analog scale. chi-square test,repeated measures one-way analysis of variance, and spearman correlation analysis tests were used to assess the data. in the comparisons, the value of p\<0.05 was accepted as significant.


Eligibility criteria:
inclusion criteria: * patients aged ≥18 years * hospitalized for laparoscopic cholecystectomy surgery, * alzheimer's, dementia etc. no disease, * having no perception problems (sense of smell, vision, hearing loss), * hospitalized the day before the operation, * patients who continue to stay in the hospital for at least one night after the operation will be included in the study. exclusion criteria: * having any respiratory system disease (copd, asthma, etc.), * disturbed by the smell of essential oils, * any allergic diagnosis and history, * using anxiolytic, antidepressant,
ocular response analyzer assessment of intraocular pressure and corneal biomechanical properties in myopic and anisometropic patients under atropine treatment

Conditions: Myopia; Anisometropia

Summary: our study has three parts has three parts, and the main aim of the study is to find out if corneal hysteresis was associated with myopia or even a predictor of myopia poor control predictor: * part 1 of our study: patients with anisomeropia whose spherical equivalent refraction as measured by cycloplegic autorefraction between the two eyes differ greater than 1.5 d. * part 2 of our study: minus spherical equivalent refraction as measured by cycloplegic autorefraction. * part 3 of our study: patients with minus spherical equivalent refraction as measured by cycloplegic autorefraction who are under regular atropine for the treatment of myopia;patients who are prescribed with atropine treatment are in need of myopia control instead of for research interest


Eligibility criteria:
inclusion criteria: 1. normal ocular health other than myopia or anisometropia 2. in good general health with no history of prematurity or cardiac or significant respiratory diseases 3. no allergy to atropine, tropicamide, proparacaine, and benzalkonium chloride 4. no previous or current use of contact lenses, bifocals, progressive addition lenses 5. no amblyopia or manifest strabismus, including intermittent tropia exclusion criteria: 1. presence of keratoconus or other corneal disease 2. previous eye drops usage except atropine 3. major ocular surgery history (including refractive surgery, scleral buckle, glaucoma filtering, cornea transplant, cataract and vitreoretinal surgery) 4. presence of other ocular conditions such as glaucoma, uveitis, or other ocular inflammatory or vitreoretinal diseases.
methadone patient access to collaborative treatment

Conditions: Opioid Use Disorder; Staff; Patients

Summary: the trial of methadone patient access to collaborative treatment (mpact) will establish the impact of the intervention on patient outcomes of methadone treatment retention and in treatment overdose. it will also establish the impact of patient and staff trauma symptoms and clinic practice change on mpact intervention implementation.

this mpact trial will involve finalizing the refined mpact intervention (materials, training) and conducting a hybrid type 1, 15-month cluster randomized controlled trial in 30 clinics with 600 patients (20/clinic) and 480 staff (18/clinic) to assess mpact effect on patient outcomes and examine the relationship between staff trauma outcomes and mpact implementation. r33 specific aims: aim 1: quantify the effects of mpact on methadone treatment (mmt) practice change and opioid treatment program (otp) culture. aim 2: determine the efficacy of mpact on mmt retention, in-mmt overdose and patient and staff post traumatic stress symptoms (ptss) outcomes. aim 3: evaluate the effect of patient and staff trauma symptoms on primary outcomes and staff mpact implementation.

Eligibility criteria:
inclusion criteria: * staff providing methadone treatment services at the enrolled opioid treatment programs exclusion criteria: * patients receiving methadone treatment at the enrolled opioid treatment programs

Keywords: methadone
the relationship of hemoglobin a1c and diabetic wound healing

Conditions: Diabetes, Type 1; Diabetes, Type 2; Foot Ulcer, Diabetic

Summary: the purpose of this study is to investigate the relationship of hemoglobin a1c in diabetic wound healing. additionally, a comparison of two wound dressings, amerigel® (amerx health care corp., clearwater, fl) and bacitracin, with and without vitamin c supplementation, will be done to evaluate impact on time to wound closure.

this is a prospective randomized controlled study evaluating the relationship of hemoglobin a1c in diabetic wound healing. length of time for wound closure will be compared using four treatment options.

Eligibility criteria:
inclusion criteria: * \>18 years of age * diabetic (type i and type ii) * ulceration of the foot at least one centimeter in width/length * ulceration at least 0.2 centimeters in depth exclusion criteria: * ulceration width/length \> 7.5 centimeters * wound depth \> 1.25 centimeters * purulent, excessive drainage and/or other signs of infection (i.e. erythema, edema, warmth) * inability to provide informed consent * inability to swallow pills (vitamin c supplement) * patients with concurrent renal problems * patients with medication contraindications to vitamin c and/or topical wound dressings

Keywords: adult