Kornimate/medical-research-clean huggingface dataset:
acupuncture and relaxation response for gi symptoms and hiv medication adherence

Conditions: HIV Infections

Summary: the aims of the study are to investigate individual, combined and added effects of acupuncture and the relaxation response in reducing gastrointestinal symptoms, improving medication adherence and quality of life among people living with hiv/aids. the study will also explore the mechanism of these therapeutic effects of acupuncture and the relaxation response.


Eligibility criteria:
inclusion criteria: 1. confirmed hiv-positive status or aids diagnosis 2. self report of having at least one of the 6 gi symptoms: diarrhea, loose stools, gas/flatulence or bloating, abdominal pain, nausea, or vomiting that have persisted for at least 8 weeks. 3. being on a stable antiretroviral regimen containing nucleoside/nucleotide reverse transcriptase inhibitors and/or protease inhibitors- for at least 8 weeks. exclusion criteria: 1. incident diagnosis of any of the following conditions within the past month or during study period: pneumocystis carinii pneumonia, kaposi's sarcoma, mycobacterium avian complex, cytomegalovirus, non-hodgkins lymphoma, lymphoma or other cancer, pelvic inflammatory disease, aids-related dementia, bacterial or other infection, diabetes, acute moderate or severe neutropenia, cryptococcus, progressive multifocal leukoencephalopathy, idiopathic thrombocytopenic purpura. all of these conditions are major opportunistic infections or medical complications that may require hospitalization and additional pharmaceutical intervention. 2. gi diagnoses of irritable bowel syndrome, crohn's disease, parasites, any type of gastric ulcer or ulcerative colitis or cancer in any part of the gastrointestinal system. these are conditions not related to hiv diagnosis and could result in digestive problems similar to those we are investigating. 3. onset of acute opportunistic infection. 4. hemophilia or other bleeding disorder since that will make acupuncture treatment unsafe. 5. pregnant women will be excluded since, although none of the acupuncture points or combinations are contraindicated in pregnancy, the presence of morning sickness could serve as a potential confounding factor. 6. current users of acupuncture for treating gi symptoms. 7. current practice of relaxation response. 8. current enrollment in another clinical intervention study. 9. cognitive impairment as measured by mini mental status examination (mmse), a reliable and valid screening instrument for the detection of cognitive impairment, using a commonly used cut-off point of 24. 10. if use of chinese herbs has been recently discontinued, a potential participant must have at least 2 weeks without herb use to be eligible for the study. because use of herbs is occasionally accompanied by digestive disorders,a period of stabilizing is required before acupuncture treatment can be initiated. this washout period has been conservatively estimated by acp staff herbalists to constitute a sufficient time for effects of herbs to cease.

Keywords: hiv/aids alternative medicine complementary medicine
ct perfusion scans in detecting changes in blood flow to the liver after portal vein embolization

Conditions: Liver and Intrahepatic Bile Duct Carcinoma

Summary: this trial studies the use of computed tomography (ct) perfusion scans in detecting changes in blood flow to the liver after portal vein embolization in patients with liver cancer. ct perfusion scans use a standard contrast drug given by vein to measure blood flow to the liver. ct perfusion scans may predict the rate and amount of growth of new, healthy tissue on one side of the liver after a portal vein embolization and detect change to the size of the liver tumor as result of the procedure.

primary objectives: i. to assess whether perfusion changes to the liver following portal vein embolization (pve) correlate with hypertrophy of the future liver remnant (flr). secondary objectives: i. to assess perfusion changes to liver tumors following pve. ii. to assess whether pve may affect tumor growth. outline: prior to pve, patients undergo ct perfusion scan of the liver and liver biopsy over 15 minutes. patients undergo a second ct perfusion scan immediately after pve and a third ct perfusion scan 3-6 weeks post pve.

Eligibility criteria:
inclusion criteria: * patients planned to undergo major liver resection for cancer who need pve to increase the size of the flr prior to surgery. * patients who are able to understand and give consent to participate in the study. exclusion criteria: * pregnant or nursing. * allergy to iodinated contrast which cannot be safely pre-medicated. * history of severe renal dysfunction (glomerular filtration rate \[gfr\] \< 30 ml/min/1.73 square meters). patients with a gfr between 30-50 ml/min/1.73 square meters will receive the standard contrast-induced nephropathy prophylaxis at our institution (i.e. n-acetylcysteine and sodium bicarbonate \[150 meq/l\] in d5w intravenous).
avalanche phenomenon during airways opening in acute respiratory distress syndrome

Conditions: Acute Respiratory Distress Syndrome

Summary: acute respiratory distress syndrome accounts for 23% of mechanically ventilated patients and is associated with high mortality rate. although life-saving, mechanical ventilation may worsen lung injury through two main mechanisms: lung overdistension and atelectrauma. indeed, the cyclic opening and closure of airways during tidal ventilation may cause lung and bronchial injuries as suggested by animal models and autopsy findings. complete airways closure has recently been described in 40% of patients with acute respiratory distress syndrome, and setting positive end-expiratory pressure above the airway opening pressure may limit atelectrauma. however, animal and mathematical models suggest that above the airway opening pressure, more distal airways open unevenly according to their own opening pressure, resulting in an "avalanche"-like phenomenon during lung inflation. this phenomenon has never been described in humans. a better understanding of the opening of airways in acute respiratory distress syndrome may help to limit ventilation-induced lung injury and to improve outcomes.


Eligibility criteria:
inclusion criteria: * age ≥ 18 * moderate-to-severe acute respiratory distress syndrome within the first 72 hours after meeting the berlin definition criteria: * within 1 week of a known clinical insult or new or worsening respiratory symptoms; * bilateral opacities (not fully explained by effusions, lobar/lung collapse, or nodules); * respiratory failure not fully explained by cardiac failure or fluid overload; * pao2/fio2 ≤ 200 mmhg with positive end-expiratory pressure ≥ 5 cmh2o. * absence of spontaneous breathing efforts * consent to participate to the study from the patient and/or its surrogate exclusion criteria: * pneumothorax * broncho-pleural fistula * tracheostomy * hemodynamic instability * severe hypoxemia * suspected of proven intracranial hypertension * chronic obstructive lung disease * pacemaker or defibrillator * decision to withhold of withdraw life-sustaining measures * under protection
dipole density mapping in supraventricular tachycardia

Conditions: Supraventricular Tachycardia

Summary: use of dipole density mapping to identify activation in complex supraventricular tachycardias.

the research study was conducted in multiple countries throughout the eu and canada. the protocol and their corresponding nct numbers are as follows: nct01914549 (protocol cl-svt-001, site belgium, bruges dr. duytschaever = pi) nct01875614 (protocol cl-svt-002, sites in the uk, drs. grace, hall, \& schilling = pis) nct03368781 (protocol cl-svt-004, site hamburg, germany prof. willems = pi) nct02469623 (protocol cl-svt-005, site prague, czech republic prof. neuzil = pi) nct02469636 (protocol cl-svt-006, site santiago, chile dr. bittner = pi) nct02469649 (protocol cl-svt-008, site ontario, canada dr. verma = pi) all of the above records were combined into one as all protocols were essentially identical and one study report was written that encompasses the data/results for all protocols.

Eligibility criteria:
inclusion criteria 1. be aged 18-75 years 2. be scheduled for ablation of an svt due to the arrhythmia being recurrent, poorly tolerated, and /or unable to be controlled with antiarrhythmic drugs. 3. be able and willing to give informed consent exclusion criteria 1. have any of the following: * implanted prosthetic, artificial, or repaired cardiac valves in the chamber being mapped * permanent pacemaker or icd leads in the chamber being mapped * hypercoagulopathy or an inability to tolerate anticoagulation during the procedure * stents in the area of the pulmonary veins (study cl-svt-004 only) 2. mi within the prior two (2) months 3. cardiac surgery within the prior three (3) months 4. intracardiac thrombus 5. clinically significant tricuspid and/or mitral valve regurgitation or stenosis 6. cerebral ischemic event (including tia) in the prior six (6) months 7. pregnant or nursing 8. currently enrolled in another clinical investigation 9. have a contraindication for transfemoral venous access (study cl-svt-004 only) 10. have a contraindication for transseptal left atrial access (for patients with left atrial arrhythmias) (study cl-svt-004 only) 11. life expectancy of less than one (1) year (study cl-svt-004 only) 12. any health condition that, in the investigator's opinion, would not allow the application of the investigational device (study cl-af-004 only) note: the additional exclusion criteria for cl-svt-004 were not expected to alter or bias the patient selection for study enrollment. while these criteria would have been assumed by other investigators as a standard of care for safe enrollment in a clinical study, the german ec approval required the additional statements.
post marketing surveillance study of byetta ™ (exenatide) use among filipino patients

Conditions: Type 2 Diabetes Mellitus

Summary: this is a prospective, non-interventional, post marketing surveillance study to determine the proportion of patients experiencing an adverse event and a list of the experienced adverse events, serious and non-serious, that would occur among filipino patients with type 2 diabetes mellitus who are treated with exenatide who are taking metformin, a sulfonylurea or a combination of metformin and a sulfonylurea but have not achieved adequate glycemic control.


Eligibility criteria:
inclusion criteria: * are male or female outpatients at least 18 years of age * provide written consent to the release of their data after being informed of the study * diagnosed with type 2 diabetes mellitus and are taking metformin, or a sulfonylurea or both * are reliable, and agree to keep all appointments for clinic visits, complete tests and procedures as may be required by the attending physician in the course of routine clinical care * are treated with exenatide according to the approved product insert, as prescribed by the investigator in the routine care of the patient exclusion criteria: * are simultaneously participating in a different study that includes a treatment intervention and/or an investigational drug. * are currently taking insulin. * are pregnant or have intentions of becoming pregnant within the duration of the study. * are the investigators or their immediate families. immediate family is defined as the investigator's spouse, parents, natural or legally adopted child (including stepchild living in the investigator's household), grandparents, or grandchild. employees of investigators are also not eligible.

Keywords: diabetes exenatide metformin sulfonylurea byetta amylin lilly
iressa™ (gefitinib) in breast cancer patients

Conditions: Breast Cancer

Summary: this is a phase ii trial to assess whether iressa™ (gefitinib) has anti-tumour efficacy in patients with breast cancer. the trial proposes to enter 27 patients who have acquired resistance to tamoxifen and 27 patients with er negative tumours. however for each of these two types of patients recruitment will stop after 14 patients have been entered in order to confirm that iressa™ (gefitinib)has anti-tumour efficacy. if no patient out of 14 in a group has shown clinical benefit (ie an objective response (cr or pr) or stable disease (sd) for at least 24 weeks) then a clinical benefit rate of \>20% can be ruled out with \>95% certainty. if one or more of the objective response or stable disease (\> 24 weeks) has been seen in the first 14 patients recruited in a group then recruitment to that group will recommence to a total of 27 patients. if 14 patients are entered into an arm but not all 14 patients are available for final analysis and the toxicity/safety and tolerability profile of the therapy is acceptable and documented and a clinical benefit is seen in the patients, enrolment of additional patients beyond the initial 14 may be made based on overall clinical assessment.


Eligibility criteria:
inclusion criteria: * histological or cytological confirmation of breast cancer that is either * a primary tumour in a patient unfit for or who has declined surgery * advanced (locally or metastatic) disease * acquired resistance to tamoxifen or er negative tumour * at least one measurable or assessable lesion * who performance status 0 - 2 * life expectancy of 12 weeks or more exclusion criteria: * more than one previous chemotherapy regimens for advanced disease * prior anthracycline chemotherapy (\> 250 mg/m2 adriamycin) * radiotherapy completed within 14 days prior to day 1 of treatment * incomplete healing from prior oncologic or other major surgery * signs of neurological symptoms consistent with spinal cord compression * any evidence of clinically active interstitial lung disease (patients with chronic stable

Keywords: oestrogen receptor er negative tumours epidermal growth factor receptor (egfr)
an observational study to assess the prevalence of heart failure in type 2 diabetes patients

Conditions: Type 2 Diabetes

Summary: an observational study to assess the prevalence of heart failure in type 2 diabetes patients in india.

this is a cross sectional, observational, multi-centre study to be conducted at 40 centres in india. the study targets to enrol 1000 patients with approx. 25 patients per site. the study would enrol type 2 diabetes mellitus patients who provide written informed consent. no study medication will be prescribed or administered as a part of study procedure. patients, who have been treated as per investigators' routine clinical practice will be screened for enrolment in study. the study will be initiated after obtaining written approval of independent ethics committee (iec) /institutional review board (irb).

Eligibility criteria:
inclusion criteria: * both men and women aged ≥ 18 years * diagnosed with type 2 diabetes (as per ada criteria) * duration of diabetes for 1 year or more * willing to provide the informed consent exclusion criteria: * patients with evidence of coronary artery disease - cad (based on the clinical expertise of the physician). * patients who were previously diagnosed with heart failure. * patients with evidence of valvular disease based on clinical judgement of the principle investigator (pi). * current treatment with digoxin. * history of symptoms of peripheral artery disease, chronic obstructive pulmonary disease and arrhythmias. * patients diagnosed with stage iii/iv ckd * diabetes other than type 2 diabetes mellitus.

Keywords: type 2 diabetes, heart failure
monocentric study on acetabulum patient-specific pin drilling guides

Conditions: Osteoarthritis, Hip

Summary: a prospective, interventional, monocentric, controlled and randomized study will compare a conventional surgical technique to a surgical technique with the assistance of the acetabular cup orientation guide (acog, materialise) system during total hip replacement (thr).

background: the acetabular cup orientation guide(acog) system from materialise nv was developed and is intended to be used as a surgical instrument to assist in the positioning of acetabular cup components intra-operatively using anatomical landmarks of the pelvis that are clearly identifiable on preoperative computed tomography (ct) imaging scans. use of acog is a relative new technique. acog, based on ct imaging data, fit directly into the patient's anatomy and enable primary total hip replacement . data showing extra benefit of this technique compared to conventional thr technique are not widely available. aim: to determine the safety of this new surgical technique compared to conventional thr. methods: 30 participants will be randomized to 2 groups. one group will be operated for a thr with the conventional technique and the other group will be operated for a thr with the assistance of the acog system. ct imaging will be taken pre and post operatively to measure cup orientation.

Eligibility criteria:
inclusion criteria: * is selected to undergo a primary thr * informed consent exclusion criteria: * is unable to undergo ct imaging of the full pelvis * requires surgical treatment within less than 4 weeks of initiation * is unable to undergo a thr through a anterolateral approach * presents acute/chronic local or systemic infection * is allergic to polyamide * patient's bmi \> 35 * patients with severe wear of the acetabular rim or other disorders that affect acetabular rim anatomy and bony landmark recognition.patients exhibiting severe wear. * has impaired decision-making capacity * is a prisoner * is pregnant * has metal components that will result in scatter on the ct imaging
a feasibility study to determine whether the botanical garden become a region of forest therapy for cancer survivors

Conditions: Neoplasms; Cancer; Mental Health Disorder; Depression

Summary: the forest healing system is an important topic of alternative therapy in recent years. to investigates forest therapy's effectiveness in alleviating negative emotions among post-cancer patients. it compares therapy outcomes at taipei botanical garden and fushan botanical garden. utilizing a pretest-posttest experimental design, a two-hour guided forest healing activity serves as the intervention method. data collection involves instrumental tests and saliva samples.

introduction: cancer's global impact persists, ranking among the top three causes of death in taiwan. despite improved survival rates after cancer surgery, negative emotions among patients remain a challenge. post-cancer depression adversely affects treatment outcomes and overall quality of life. forest therapy, a natural healing approach, has gained attention for its potential to reduce stress, mitigate negative emotions, and enhance well-being. objectives: this study investigates forest therapy's effectiveness in alleviating negative emotions among post-cancer patients. it compares therapy outcomes at taipei botanical garden and fushan botanical garden. additionally, the study explores the lasting emotional benefits of forest therapy. methods: utilizing a pretest-posttest experimental design, this study is conducted at the botanical garden in fushan, taipei. participants are cancer patients who are six months post-treatment. a two-hour guided forest healing activity serves as the intervention method. data collection involves instrumental tests and saliva samples. a comparable location adjacent to taipei botanical garden, excluding urban areas, is selected for comparison activities. portable heart rhythm monitors track data, and saliva samples are analyzed for salivary α-amylase enzyme kinetics and cortisol concentrations. the study employs questionnaires including the profile of mood states 2nd edition-adult short (poms2-a short), beck depression inventory-second edition (bdi-ii), beck anxiety inventory (bai), and the abbreviated taiwan version of the world health organization quality of life-brief (whoqol-bref).

Eligibility criteria:
inclusion criteria: * over 20 year-old * cancer patients finished cancer treatments more than 6 months (regardless hormone therapy) * voluntary attendance exclusion criteria: * people who unable to walk for at least 120 minutes * people who still smoking, chewing betel nut or drinking alcohol (over five standard cups in any situation) * people who addicted to medicine * people who attend another clinical trial at the same time or in the follow-up period of an interventional trial * pregnant women or breast feeding * other conditions that participants unable to cooperate with

Keywords: forest therapy forest healing cancer survivors mental health disorder
patient perceptions and physician assessment of benefits and risks of oral anticoagulation due to non-valvular af

Conditions: Atrial Fibrillation; Health Literacy

Summary: the risk of stroke is markedly elevated in patients with atrial fibrillation (af). oral anticoagulation (oac) is indicated in individuals with moderate and high risk of stroke to the disadvantage of an increased burden from bleeding. adequate knowledge of this disorder and understanding the benefits and hazards of antithrombotic treatment are essential to incorporate patient´s values and preferences in these decisions. this will further improve acceptance of recommended therapy and augment compliance with oac. the objective of this investigation is to compare patient´s perceptions and physician´s assessments of benefits and risks of oac.


Eligibility criteria:
inclusion criteria: * diagnosed and ecg-documented non-valvular atrial fibrillation * new indication for oral anticoagulation (oac) * ability of informed consent exclusion criteria: * existing oac therapy * valvular heart disease * history of valve surgery
vegetable intake effect on heterocyclic amine metabolism

Conditions: Colon Cancer

Summary: this is a randomized trial with crossover design, where each participant will undergo four study phases with a different test meal at the end of each phase. every phase will consist of subjects consuming for six days their normal diet excluding cruciferous and apiaceous vegetables, alcohol, and caffeine. the participants will refrain from meat products for 24 hours prior to the test meal. on day seven of each phase and after an overnight fast, subjects will be randomly assigned to eat one of four meals: 1. grilled hamburger with no vegetables 2. grilled hamburger with steamed broccoli and brussels sprouts 3. grilled hamburger with steamed parsnips, fresh parsley, and celery sticks 4. grilled hamburger with steamed broccoli, brussels sprouts, and parsnips plus fresh parsley and celery sticks.

colon cancer is the third most common cancer in the u.s. convincing evidence suggests that high intake of red meat increases colon cancer risk, according to the 2007 aicr/wcrf second expert report. the likely responsible mutagens are heterocyclic aromatic amines (haa), which form naturally during the cooking of meat, poultry, and fish at high temperatures. bioactivation of haa to carcinogenic metabolites is primarily mediated by phase i biotransformation enzymes. evidence suggests that the activity of many of these enzymes can be modulated by constituents in apiaceous vegetables (parsnips, celery, etc.) and cruciferous vegetables (broccoli, cabbage, etc.) in this trial researchers are comparing the effects of eating cruciferous vegetables, apiaceous vegetables, or both groups combined on haa metabolism after eating grilled hamburger together in a single meal. they aim to define optimal dietary patterns and food combinations that maximize the safe excretion of dietary carcinogens through this trial. this contribution is significant because the knowledge gained will be applicable to the prevention of colon cancer as well as additional cancers.

Eligibility criteria:
inclusion criteria: * 18 years old or older * healthy * non-smoker exclusion criteria: * no history of gastrointestinal, hepatic, or renal disorders * not currently taking any prescription or over-the-counter medications * not currently taking any herbal/vitamins supplements * not pregnant or lactating * no allergies or intolerances to the foods that will be used in the study (parsnips, parsley, celery, broccoli, brussels sprouts, and hamburger)

Keywords: haa heterocyclic aromatic amines apiaceous vegetables cruciferous vegetables