Kornimate/medical-research-clean huggingface dataset:
developing an effective intervention to address post-corona-virus-disease-2019 balance disorders, weakness and muscle fatigue in individuals aged 65+

Conditions: COVID-19

Summary: the long-term consequences and sequelae of covid-19 are still unclear; however, a vast number of elderly individuals have reported prolonged general weakness and muscular fatigue, leading to significant functional decline, increased risk of falls, morbidity and mortality rates. however, effective exercise intervention for such post-covid-19 patients is still not well documented. previous studies indicate that, in general, resistance training (rt) appears to be the most effective, safe method for combating the loss of muscle mass, strength and functional capacity. the aim of investigators study is to develop/adopt an effective intervention specifically for elderly (65+) people with post covid-19 condition, experiencing balance disorder and muscle weakness, in order to help them return to pre-infection mobility and function. this will be a randomized controlled study with pre- and post-intervention assessment. the participants will be recruited from nursing homes, retirement facilities, universities of the third age, primary health care units (pozs), in keeping with the inclusion criteria. the patients will be randomized to one of 2 groups: rt and control (no exercise). the participants' muscle strength under dynamic condition, balance (especially fall risk), body composition and quality of life will be assessed pre- and post-intervention. the investigators main research outcome - safe exercise protocols and interventions - will be developed to match the needs of the elderly in the current pandemic (and post-pandemic) scenario, in order to maintain/improve the health, balance, muscle strength, cognitive function and, consequently, quality of life of older adults affected by covid-19.


Eligibility criteria:
inclusion criteria: * positive polymerase chain reaction test * positive result in test for antibodies against the severe acute respiratory syndrome-corona virus -2 coronavirus 3-12 months prior to the study start exclusion criteria: * cardiac dysfunction, * stress disorder, * oxygen desaturation, * dysfunction of the autonomic nervous system (orthostatic intolerance)

Keywords: post-covid-19 elderly individuals balance disorder
quality of life and efficacy evaluation of patient self-monitoring their oral anticoagulation therapy

Conditions: Anticoagulants; Quality of Life; Drug Monitoring; Pharmacy; Ambulatory Care

Summary: the purpose of this study is to determine whether self-management of oral anticoagulation therapy with warfarin has an effect on patient's quality of life following a specific training program led by pharmacists.


Eligibility criteria:
inclusion criteria: * patient aged 18 years and over followed at the montreal heart institute's anticoagulation clinic * warfarin treatment planned for at least 4 months after inclusion in the study * warfarin treatment initiated for at least 6 months * last 2 inrs between 1.5 and 4 if target inr is between 2 and 3 * last 2 inrs between 2 and 4 if target inr is between 2.5 and 3.5 * provide a signed informed consent exclusion criteria: * patient unable to understand (spoken and written) french or english * patient refuses or is unable to attend the required training sessions * targeted inr other than 2 to 3 or 2.5 to 3.5 * handicap or physical limitation compromising the patient's ability to initiate self-monitoring in the absence of a proxy helper * moderate to severe cognitive impairment or important comprehension problems * active neoplasm * concurrent chemotherapy * hypercoagulable conditions * life expectancy of less than 1 year documented in the medical chart * inclusion (at time of inclusion or 30 days prior to inclusion) in another research project involving a drug * patient anticoagulated with nicoumalone * pregnancy or breastfeeding * active bleeding (except for menses) * recent major bleeding (less than 3 months before inclusion) * stroke, acute coronary syndrome, percutaneous coronary intervention, coronary artery bypass graft, cardiac valve replacement, deep veinous thrombosis or pulmonary embolism in the 3 months prior to inclusion * any other condition that, in the opinion of the investigators, of the treating physician or of the healthcare professionals working at the anticoagulation clinic could make self-management by the patient impossible

Keywords: coaguchek portable coagulometer self-monitoring coumadin warfarin quality of life pharmacist
incidence of acute renal failure associated with iodinated contrast agents in pediatrics

Conditions: Acute Renal Insufficiency

Summary: iodinated contrast media are now frequently used in diagnostic imaging exams, including pediatrics. in adults, the acute renal failure (arf) associated with contrast agents (ca-aki) occur in 3-33% of exposed patients, especially as the patient is fragile, has comorbidities or pre-existing renal aggression . in children, the prevalence of this little known disease is probably underestimated. the investigators intend to conduct a prospective epidemiological study, to estimate the impact of the acute renale failure to iodinated contrast agents in pediatrics.

patients will be included those of pediatric emergencies, hospitalization unit of short duration pediatric, pediatric intensive care and pediatric resuscitation. the acute renale failure will be estimated on the basis of criteria kdigo (score of kidney disease) group in 2012 to 48 hours a computed tomography (ct) scan with injection of contrast media, based on a change in creatinine clearance of the estimated according to the formula schwartz revised in 2009 and / or diuresis. patient characteristics will be identified in order to establish risk factors.

Eligibility criteria:
inclusion criteria: * patients under 16 years admitted to a participating service * patient receiving an injected ct scan exclusion criteria: * prior inclusion in the study during an earlier review. * opposition of parents. * chronic renal failure or end-stage requiring renal replacement in the long term.

Keywords: acute renal insufficiency iodinated contrast agents pediatric
observational research on infectious disease outbreaks and difficult cases of unidentified etiology in indonesia

Conditions: Infectious Disease

Summary: this observational study will investigate suspected infectious diseases of unknown etiology prospectively during outbreaks and at healthcare facilities, and retrospectively through historical samples where no etiology was ever determined. the study is designed to rapidly, flexibly, and consistently respond to any potential scenario in indonesia, and the data collected will provide needed insight into the landscape of infectious diseases in the country. by better understanding the infectious causes of outbreaks and difficult hospitalized cases, the indonesian ministry of health will be able to more accurately and efficiently control infectious diseases and craft healthcare policies.

this is a study to identify the causative agents and describe the clinical characteristics of infectious disease outbreaks and difficult cases of unidentified etiology in indonesia. it is a retrospective and prospective observational study with an exploratory design. there will be no intervention to the participants that is intended to affect their soc or clinical outcome. retrospective study activities will be ongoing throughout the duration of the study. the ina-respond reference lab will perform research tests on various specimens collected as part of historical outbreaks and previous difficult cases where an etiology was never identified. prospective study activities will be initiated upon official request from health authorities and health facilities/institutions. requests are expected to be filtered through and evaluated by the 19 active ina-respond network sites before inclusion in the study. samples collected during outbreaks and from difficult cases of unknown etiology will be analyzed at the ina-respond reference lab at their own pace. results from any research tests will be shared with the requesting authorities as research-use-only and are not intended to alter standard of care.

Eligibility criteria:
inclusion criteria: 1. adult or child of any age hospitalized with a current episode of illness with a presumed infectious disease of unidentified etiology 2. negative for dengue virus infection by an antigen-based and antibody-based diagnostic test (i.e. ns1 antigen test and dengue-specific igm test) 3. negative for salmonella typhi infection by standard of care testing (i.e. blood culture, widal test, or tubex rapid test) 4. able to provide a documented informed consent 5. agrees to the collection and storage of specimens for laboratory testing and/or future research (participants may decline storage of specimens for future research) 6. for ongoing patients in outbreak situations: referral from the moh as part of a suspected or identified outbreak of infectious disease exclusion criteria: * investigators' discretion for patient safety and well being

Keywords: infectious disease
plasma immunity of mild sars-cov-2 omicron and delta pandemic in thailand

Conditions: COVID-19

Summary: the investigators assessed the effect of treatment for covid and immunity of the volunteers who admitted to the home isolation.

the investigators aimed to assess the effect of treatment for covid and immunity of the volunteers who admitted to the home isolation. the investigators compared the population between the age groups 12-18 years, 18-45 years and over 45 years to monitor the symptoms of coronavirus patients treated in home isolation and long-term symptoms including factors related to the patient's recovery in the past, present, and future.

Eligibility criteria:
inclusion criteria: 1. patient with infected with the novel coronavirus disease 2019 (covid-19) who has been end of self-quarantine at siriraj hospital more than 21 days. 2. thai nationality, able to read and write thai language 3. able to use telephone and line to communicate exclusion criteria: 1. people who received additional vaccination after leaving quarantine before the day of the immunization test

Keywords: covid-19 antibody immunity home isolation vaccine
fetal heart rate changes and labor neuraxial analgesia: a machine learning approach

Conditions: Fetal Bradycardia

Summary: this study aims to perform statistical inference and prediction of changes in fetal heart rate during active labor in healthy pregnant women by comparing three different machine learning methods

purpose: this study aims to perform statistical inference and prediction of changes in fetal heart rate during active labor in healthy pregnant women by comparing three different machine learning methods. methods: a retrospective analysis of 1077 healthy laboring parturients receiving neuraxial analgesia was conducted. we compared a principal components regression model with treebased random forest, ridge regression, multiple regression, a general additive model, and elastic net in terms of prediction accuracy and interpretability for inference purposes.

Eligibility criteria:
inclusion criteria: * older than 18 years * pregnancy requiring labor analgesia * active labor * request of neuraxial analgesia per patient and/or obstetrician * received combined spinal-epidural technique exclusion criteria: * uterine tachysystole before neuraxial analgesia. * baseline blood pressure \<90/60 mmhg. * third trimester hemorrhage * eclampsia * allergies to local anesthetics or fentanyl. * maternal fever. * pruritus before performance of neuraxial analgesia
bax 326 (rfix) continuation study

Conditions: Hemophilia B

Summary: the purpose of this bax 326 continuation study is to further investigate incremental recovery over time, the hemostatic efficacy, the safety, immunogenicity, and health-related quality of life (hr qol) of bax 326 in previously treated patients (ptps) with severe and moderately severe hemophilia b who participated in bax 326 pivotal study 250901 or bax 326 pediatric study 251101.


Eligibility criteria:
main inclusion criteria: * subject and/or legal representative has/have voluntarily provided signed informed consent * subject has completed baxter clinical study 250901 (pivotal study) or baxter clinical study 251101 (pediatric study) * subject was 12 to 65 years old at the time of screening for study 250901 or \< 12 years old at the time of screening for study 251101 * subject has severe (fix level \< 1%) or moderately severe (fix level 1-2%) hemophilia b (based on the one stage activated partial thromboplastin time (aptt) assay), as tested at screening at the central laboratory * subject has not developed an inhibitory fix antibody during baxter pivotal study 250901 or pediatric study 251101 main exclusion criteria: * subject received factor ix product(s) other than bax 326 upon completion of baxter pivotal study 250901 or pediatric study 251101 * subject has been diagnosed with an acquired hemostatic defect other than hemophilia b * for subjects transferring from pivotal study 250901: subject's weight is \ 120 kg * subject is planned to take part in any other clinical study, with the exception of bax 326 surgery study as described in this protocol, during the course of the continuation study
phosphorus, proton imaging and amyloid burden (prepare) on amyloid burden and cognition

Conditions: Alzheimer Disease

Summary: normal cells primarily produce energy with the help of the "mitochondria". these "small organs" are also called the "powerhouses of the cell" turn the sugars, fats and proteins that is eaten into forms of chemical energy that the body can use to carry on living. this process is called oxidative phosphorylation. in addition to the help from the mitochondria and oxidative phosphorylation, most cells can produce energy by lactic acid fermentation. this process is less energy efficient but faster and used by the brain, muscle or other organs under specific circumstances and energy demands, even in the presence of abundant oxygen. it is also called aerobic glycolysis. aerobic glycolysis and oxidative phosphorylation are the two major mechanisms involved in brain energetics.

the consequences of alzheimer's disease (ad) (deposition of amyloid plaques and neurofibrillary tangles) are known. the cause of these deposition of proteins is not. some scientist argue that an increase in oxidative phosphorylation activity and a lack of ability to shift to aerobic glycolysis are the underlying source of these changes. the purpose of this study is to test whether there is a correlation between neuroenergetic levels of aerobic glycolysis/oxidative phosphorylation and risk for alzheimer's disease. the study will examine these neuroenergetic adaptations in a group of 15 elderly participants (age range: 70-85 y/o) with amnestic mild cognitive impairment (amci) and 30 cognitively normal controls (nl). multimodal (mr/pet) and multinuclear (31p/1h) neuroimaging will allow us to gain access to a uniquely comprehensive and highly consistent view of neuroenergetic adaptations in both the clinical and preclinical stages of alzheimer's disease.

Eligibility criteria:
inclusion criteria: * nl group: adults (male and female) aged \>70 years in overall excellent health with normal cognition (cdr=0), and at least high school graduate level education. * amci group: adults (male and female) aged \>70 years, clinical dementia rating (cdr)= 0.5 - 1 and mini-mental state examination (mmse): 20-25 * english as first language or demonstrated proficiency in english for non-native speakers exclusion criteria: * any tumor, stroke, or trauma that would result in abnormal radiological findings history of bipolar disorder, schizophrenia, intellectual disability or substance abuse mri scanner contraindications
ketamine versus neostigmine as adjuvants to bupivacaine during ultrasound-guided serratus anterior block

Conditions: Post Operative Pain

Summary: this study is designed to investigate the analgesic efficacy of ketamine compared to neostigmine as adjuvants to la in ultrasound guided serratus anterior plane block (sapb) in patients undergoing modified radical mastectomy. we hypothesize that adding either neostigmine or ketamine to bupivacaine in ultrasound guided sapb would increase the total analgesic duration and decrease the total 24 hr postoperative nalbuphine consumption compared to sapb with bupivacaine only. the first 24 hr of postoperative nalbuphine consumption is set as the primary outcome. the time of the first request of analgesia, pain score, side effects of drugs and patient hemodynamics are set as the secondary outcomes.


Eligibility criteria:
inclusion criteria: * asa ii patients, bmi\< 35kg/m2 exclusion criteria: * refusal of participation, asa iii or above, history of allergy to the study drugs, bmi\> 35kg/m2, coagulation disorders, psychiatric illnesses that may interfere with pain evaluation, epileptic patients, patients with tachy or brady arrthymias, patients with increased intracranial tension

Keywords: mastectomy postoperative pain serratus anterior block adjuvants
ecg triggered dual source ct for non-invasive pre-operative cardiac imaging in morbid obese patients

Conditions: Obesity, Morbid

Summary: coronary arterial disease is a risk factor for bariatric surgery and might be a predictor for later major adverse coronary events. diagnosis of coronary arterial disease would thus be desirable for obese patients, however percutaneous angiography is an invasive procedure and associated with a certain morbidity in obese patients. in this study the investigators would like to assess whether dual source ct angiography can be used for diagnosis of coronary arterial disease in severely obese patients and which settings yield the best image quality.

obesity is a major health problem in many countries and a major risk factor for cardiovascular disease. extreme obesity can be treated with surgery, however these procedures are associated with a certain surgery-related morbidity which increases with comorbidities, in particular coronary diseases. thus, preoperative cardiac risk assessment would be desirable, however percutaneous coronary angiography is an invasive procedure with problems and complications in obese patients. a non-invasive alternative would be coronary dual-.source ct angiography (ccta), however little experience exists in the application of ccta in morbid obese patients. this study would like to address the following issues: 1. comparison of image quality of coronary ct angiography using a dual source ct from obese patients using a special protocol (140 kv, 350 mas) with images from historical controls from normal weight patients with a standard protocol (120 kv, 330 mas). 2. prediction of major adverse coronary events. patients with a coronary stenosis in ccta will be followed for any major adverse coronary events (details see outcomes) 3. is it possible to detect myocardial fat by a reduced ct density. images from obese patients will be compared to historical controls from normal patients. furthermore, is the myocardial ct density correlated with the bmi of obese patients? 4. optimisation of scan protocol. increasing the scanning angle beyond the standard 90° will reduce the signal noise at the cost of temporal resolution. various scanning angles with be tested for an optimal combination of signal noise and temporal resolution. 5. does the long qt-syndrome improve after bariatric surgery? it is assumed that the long qt-syndrome is a consequence of fattening of the myocardia. is it possible to see a reduction of myocardial fattening and thus an improvement of the long qt-syndrome with ct during the follow-up after bariatric surgery?

Eligibility criteria:
inclusion criteria: * morbid obesity (bmi \>35 kg/m²) * intention to undergo bariatric surgery * increased risk for coronary artery disease (based on procam score) exclusion criteria: * kidney insufficiency (serum creatinine \>100 µmol/l, creatinine clearance \<50 ml/min) * allergy to iodine containing contrast agents * hyperthyroidism * metformin medication * pregnancy

Keywords: obesity dual source ct coronary ct angiography prognosis bariatric surgery gastric bypass surgery coronary arterial disease major adverse coronary event
paravertebral block with brachial plexus block for upper arm arteriovenous fistula surgery

Conditions: Regional Anesthesia Success

Summary: the primary goal of this quality improvement project is to find the optimal surgical conditions for patients undergoing upper arm arteriovenous graft surgery. currently, there are two anesthetic techniques used in clinical practice. the goal is to standardize future practice and improve the care of patients postoperatively. the two techniques used in conjunction with a brachial plexus block are paravertebral nerve block and subcutaneous infiltration.

this study is designed to test the null hypothesis that paravertebral nerve block or subcutaneous infiltration provide similar operating conditions when combined with supraclavicular nerve block for upper arm arteriovenous fistula surgery. the results will help determine which approach to use and guide future research in this area.

Eligibility criteria:
inclusion criteria: * adult patients (\>18 years) undergoing upper limb arteriovenous fistula surgery at unc chapel hill hospital exclusion criteria: * contraindication to regional anesthesia * significant peripheral neuropathy or neurological disorder of the upper extremity * cognitive or psychiatric condition that will interfere with patient assessment