Kornimate/medical-research-clean huggingface dataset:
intensive rehabilitation in peripheral arterial disease with claudication: effects of a treadmill training with active recovery

Conditions: Peripheral Arterial Disease; Claudication

Summary: rehabilitation is the first intention treatment of peripheral arterial disease (pad) with claudication. initially proposed in the sixty's, rehabilitation programs dedicated to patients with pad have recently been proved effective and defined in many guidelines. supervised walking training on treadmill is recommended. usually patients walk up to a mild or moderate pain (evaluated at 3 or 4 on the claudication pain scale; maximum pain =5), then stop until pain completely subsides and walk again . the artex study assesses the efficacy of a fractionated mode of training avoiding pain by alternating short sequences of intensive training and active recovery (without rest).

fractionated mode of training with active recovery has been proved effective in sport training as well as in cardiac rehabilitation. we hypothesized it might be also interesting in the rehabilitation of patients with a peripheral arterial disease. the active recovery period might magnified the beneficial effect of a short intensive training.

Eligibility criteria:
inclusion criteria: * patient (male/female) between 18 and 80 years * patient with fontaine stage ii pad confirmed by clinic, duplex ultrasound and ankle-to-brachial systolic blood pressure index * cardiac status compatible with an intensive gait rehabilitation (checked by a consultation with a cardiologist, including interview, clinical examination, electrocardiograph, and effort test on ergocycle). * volunteer to take part in the study, having sign the consent form after receiving sufficient information and the information leaflet * person affiliated to social security or the recipient of a similar scheme not inclusion criteria: * exercise tolerance limited by other factors than claudication (eg, coronary artery disease, dyspnea, poorly controlled blood pressure * walking limited by other pathology * osteoarticular lower limbs pathology * abdominal aortic aneurysm \> 4 cm * pseudo-flu-like feverish syndromes in evolution (myocarditis or pericarditis) * person deprived of liberty by a legal or administrative decision, person under legal protection * person currently participating in a clinical trial or having taken part in a clinical trial in the month preceding inclusion * patient presenting with a history of mental or psychiatric illness or any other factor restricting his/her ability to participate in an informed manner and in compliance with the protocol exclusion criteria: impossibility to perform protocol whatever reason

Keywords: assessment rehabilitation walking constant test walking graded test six minute walking test walking distance
longitudinal follow-up of brown adipose tissue function and structure

Conditions: Obesity

Summary: in turku pet centre, there have been 3 positron emission tomography studies on brown adipose tissue (bat) activity in healthy adults. batpet was performed between 2008 and 2009. fatbat started in 2011 and dixon-bat in 2012 and they are both currently ongoing. in the current study, participants of batpet, fatbat and dixon-bat studies are recruited for a follow-up study to examine associations between obesity, cardiovascular risk factors, serum metabolic profile and bat structure at baseline and during follow-up several years later. 43 batpet participants will be called for follow-up in 2013 with a follow-up period of 5 years and 52 fatbat and dixon-bat participants in years 2014 and 2015 with a follow-up period of 3 years. the aim of this study is to examine longitudinal associations between bat function and structure, liver adiposity and cardiovascular risk factors at baseline and during follow-up.


Eligibility criteria:
inclusion criteria: * all study subjects have been screened prior to acceptance in batpet, fatbat and dixon-bat studies and no screening for inclusion is required in the current study. exclusion criteria: * 1) smoking 2) blood pressure \> 160/100 mmhg 3) pregnancy or lactation 4) medication (expected effect on study variables)

Keywords: positron emission tomography magnetic resonance imaging brown adipose tissue obesity cardiovascular disease subclinical atherosclerosis
targeted optical biopsy for local rectal scars in rectal cancer patients after neoadjuvant chemoradiotherapy

Conditions: Rectal Cancer

Summary: currently, low concordance (36%) is found between clinical complete response and pathologic complete response in patients with rectal cancer after neoadjuvant chemoradiotherapy. probe-based confocal laser endoscopy (pcle) provides a promising targeted optical biopsy to evaluate the response to neoadjuvant chemoradiotherapy. the aim of this study is to investigate whether pcle-targeted optical biopsy can improve the accuracy of preoperative endoscopic biopsy for local rectal scars in rectal cancer patients after neoadjuvant chemoradiotherapy.

patients with locally advanced rectal cancer can benefit from neoadjuvant chemoradiotherapy, and 20%-30% of patients receiving such therapy can attain a pathologic complete response, defined as the eradication of cancer cells. for those who reach pathologic complete response, a watch-and-wait strategy is supposed to be the best choice. however, low concordance (36%) was found between clinical complete response and pathologic complete response in patients with rectal cancer after neoadjuvant chemoradiotherapy. there is a compelling need to improve the consistency. probed-based confocal laser endoscopy (pcle) is a novel endoscopic adjunct that allows real-time in vivo histological examination of mucosal surfaces. by using intravenous fluorescent agents, pcle highlights certain mucosal elements that facilitate an optical biopsy in real time. it provides a promising targeted optical biopsy for local rectal scars in rectal cancer patients after neoadjuvant chemoradiotherapy. the investigators perform this study to investigate whether pcle-targeted optical biopsy could improve the accuracy of preoperative endoscopic biopsy for local rectal scars in rectal cancer patients after neoadjuvant chemoradiotherapy. in this study, rectal cancer patients after neoadjuvant chemoradiotherapy will be successively arranged to accept traditional endoscopic biopsy and pcle-based targeted optical biopsy. the consistency rate will be calculated according to the postoperative pathological results.

Eligibility criteria:
inclusion criteria: 1. age from over 18 to under 80 years 2. american society of anesthesiology(asa) score class i,ii,or iii 3. locally advanced rectal cancer 4. patient has completed standard neoadjuvant therapy 5. expected surgical resection 6. written informed consent exclusion criteria: 1. pregnant or lactating women 2. acute renal insufficiency or stage ii to iv chronic renal insufficiency 3. patients with allergic constitution

Keywords: rectal cancer confocal laser endomicroscopy optical biopsy
changes in penile firmness with low-intensity shockwave therapy (list)

Conditions: Erectile Dysfunction

Summary: patients presenting with erectile dysfunction are often found to have increased corporal firmness on elastography. we hypothesize that this corporal firmness reflects reversable changes that can be altered by low-intensity shockwave therapy (list). in this pilot study patients found to have increased corporal firmness will be treated with list.

this study will enroll men between the ages of 18 and 65 with corporal cavernosal firmness on elastography. the participants study duration is 3 months long and includes eight visits at the study center. study visits consist of physical exam, vital signs, questionnaires, blood draws, and administration of low-intensity shockware therapy (list). low intensity extracorporeal (i.e., outside the body) shockwave therapy (list) is a treatment that has been in use since 2010 and has become commonly used internationally and in the united states since 2015. the device applies a low-intensity shockwave to the surface of the penis using an ultrasound gel as the coupling agent. the study will evaluate changes in corporal cavernosal firmness and changes in penile vascular blood flow.

Eligibility criteria:
inclusion criteria: 1. provision of signed and dated informed consent form 2. stated willingness to comply with all study procedures and availability for the duration of the study 3. men aged 18-64 4. sexually active men and evidence of increased firmness on elastography during their standard evaluation for erectile dysfunction. exclusion criteria: 1. within two weeks of visit 1 using erectogenic medications including pde5 inhibitors and/or penile injection therapy 2. presence of a penile implant. 3. presence of cardiac pacemaker or defibrillator 4. patients who are using devices which are sensitive to electromagnetic radiation. 5. screening ultrasound positive for testicular cancer 6. presence of untreated prostate cancer 7. patients with severe coagulation disorders 8. patient that in the opinion of the principal investigator would be non-compliant with the study
effect of pilates exercises on stress urinary incontinence in posmenopausal women

Conditions: Urinary Stress Incontinence

Summary: • this study will be conducted to determine the effect of pilates exercises on stress urinary incontinence in postmenopausal women

pilates exercises help in the controlled movement of the core, that act as a corset and it activates both core muscle and synergistically the pfm. (trantafylidis, 2009). there is limited evidence regarding the use of pilates exercises for the management of stress urinary incontinence (sui) in older women (keri, 2013; pyria et al, 2021). so this study will be conducted to determine the effect of pilates exercises on sui in postmenopausal women which provide an insight about the benefits of such exercise on postmenopausal sui.

Eligibility criteria:
inclusion criteria:postmenopausal women (at least 12months after menstrual cessation), diagnosed with sui by the gynecologist. * their ages will range from 50-60 years old . * their bmi will be less than 30kg/m2 . * all of them suffer from mild to moderate degree of sui . * all of them delivered vaginally. * all are multipara with 2 or more children. * all are of sedentary life style. exclusion criteria:women will be excluded from the study if they have: * previous bladder surgery. * post pelvic radiotherapy. * vaginal/abdominal hysterectomy. * vaginal infection. * severe urinary tract infection. * uterine prolapse
effects of combined segmental vibrator and neuromuscular electrical stimulation in subacute stroke

Conditions: Subacute Stroke

Summary: stroke is leading cause of death and disability worldwide, resulting in significant functional limitations and disabilities experienced by stroke survivors, particularly in the upper limb. there is a need for more effective interventions targeting upper limb sensory motor impairments. the aim of this study is to study combined effect of segmental vibrator and neuromuscular electrical stimulation for flexor and extensor muscle groups on upper limb function in sub-acute stroke.

this study will be a randomized clinical trial and will be conducted in physiotherapy department of allama iqbal memorial teaching hospital sialkot, national bone and joint hospital and bashir hospital sialkot. forty stroke patients will be recruited through non-probability convenience sampling technique and will be randomly divided in two equal groups group a and group b through lottery method. group a will receive high frequency segmental vibration on flexor and extensor muscle groups while group b will receive neuromuscular electrical stimulation along with high frequency segmental vibration(100hz) on flexor and extensor muscle groups data will be collected from patients of sub-acute stroke by using screening tool moca(for cognition) and assessment tools fugl-meyer assessment scale(for upper limb function), wolf motor functional test(for motor function), modified ashworth scale(for spasticity) , barthel index(for adls), maximal hand grip strength(for manual dexterity), maximal pinch grip(for manual dexterity), nottingham sensory assessment(for somatosensory function). an informed consent will be taken. outcome measures will be assessed at baseline, at 4th week and at 8th week. follow up will be performed at 12th week. data analysis will be done by spss version 28.0.

Eligibility criteria:
inclusion criteria: * patients of both genders * aged between 45 and 65 years old * first ever ischemic stroke experienced more than 3 months before the enrollment * spasticity of spastic agonist muscles ranging from 0-2 on the mas exclusion criteria: * patients with bilateral brain lesions * ischemic involvement of cerebellum or basal ganglia * psychiatric disease and cognitive impairment * previous history of other neurological diseases,rheumatic and orthopaedic conditions * patients under anti-spastic therapy or other clinical trials * metal implants e.g. cardiac pacemakers
early detection and staging of endobronchial lung and pleural cancer, airway injury, and prostate cancer

Conditions: Lung Cancer; Pleural Cancer; Prostate Cancer

Summary: this study has been designed to utilize already obtained biopsy specimens for investigation of the utility of a new, non-invasive optical diagnostic technique. the study will allow a careful correlation between the optical coherence tomography findings and conventional histology.

optical coherence tomography is a non-invasive diagnostic technique that can provide information about tissue abnormalities, change in structure of an organ. this technique uses a near-infrared diode to emit light that can produce images of the specimen under investigation without causing damage or alterations.

Eligibility criteria:
inclusion criteria: * adult 18 years and older * having procedure of endobronchial, transbronchial, and / or pleural biopsy exclusion criteria: * currently participating in any other investigational drug or device evaluation. * currently taking drugs that are sensitive to light.

Keywords: early detection of lung and pleural cancer early detection of prostate cancer
investigation of the effectiveness of manual therapy plus cervical stabilization exercise in chronic neck pain

Conditions: Neck Pain

Summary: this study aims to investigate the effectiveness of manual therapy plus cervical stabilization exercise compared to manual therapy alone on balance, proprioception, and neck muscle morphology in chronic neck pain.

neck pain is defined as pain and/or stiffness localized to the dorsal area of the area between the condyle of the occiput and the third thoracic vertebra. chronic neck pain (cnp), defined as persistent pain lasting three or more mounts, causes disability and a reduction in life quality. balance disorders or postural instability, a deficit in proprioception, changes in muscle recruitment, a decrease in dimension of deep cervical muscle, and an increase in stiffness of superficial neck muscle may lead to pain in patients with cnp. both manual therapy and exercise have favorable effects on management with cnp. according to our knowledge, no study has investigated the effects of manual therapy plus cervical stabilization exercise on balance, proprioception, and neck muscle morphology in cnp, yet.

Eligibility criteria:
inclusion criteria: * 20 to 55 years of age, * having generalized neck pain for more than 3 months, * being volunteer exclusion criteria: * being pregnant, * malignancy, * having cervical stenosis, * severe cervical spondylosis, * cervical fractures and tumor, * osteoporosis, * positive vertebrobasilar test * positive babinski reflex * neurologic deficit related to compression of the spinal root or cord, * having neurologic, dermatologic, infectious, inflammatory rheumatologic and endocrine diseases, * being an inability to fulfill the questionnaires, * any problems that will hinder exercise (advanced cardiopulmonary or orthopedic problems), having intervention including exercise program or physiotherapy in the three months

Keywords: neck pain manual therapy exercise postural control
evaluation of middle ear implantation

Conditions: Hearing Loss

Summary: the middle ear implant are used for patients with mild to severe sensorineural hearing loss, who cannot benefit from conventional hearing aids because of medical reasons such as chronic external otitis or external skin irritation. the device is also available for patients who are dissatisfied with the conventional hearing aids because of poor sound quality, feedback or occlusion of the ear canal. to date, more than 1500 patients have been implanted in europe and about more than 600 patients in france. the aim of the present study is to compare in a randomized study the performances of the system to those of the conventional hearing aid in patients with similar degree of hearing loss.

objective: the main objective of this study is to demonstrate that the middle ear implant increases the hearing in terms of speech intelligibility in quiet and noisy conditions, in patients who have no further benefit of their conventional hearing aid. the quality of life of these patients will be evaluated as well as the tolerance of the middle ear implant after 6 months. design of the study: 420 patients with mid or severe hearing loss will be included. they will have for 3 months the best conventional hearing aid adapted to their hearing loss. the first 84 patients who will not have a benefit of this hearing aid, will be randomised in two groups. the patients of the first group will be operated as soon as possible, the surgery of the patients of the second group will be delayed by 6 months. the whole duration of the study is 48 months. evaluation criteria: audiological testing (pure-tone hearing thresholds, speech comprehension in quiet and noise), and subjective evaluation using self-assessment scales will be performed before and 6 months after the implantation in the two groups.

Eligibility criteria:
inclusion criteria: * adults patients * hearing loss * accept to participate * having health insurance exclusion criteria: * known disease that needs mri follow up * contraindication to middle ear surgery

Keywords: hearing auditory rehabilitation middle ear implant surgery
outcomes of migraine surgery

Conditions: Migraine

Summary: migraines are very common and affect over 35 million americans a year. migraines can be painful and affect daily life. the cause of migraine is multifactorial and not completely understood. treatment usually includes different classes of medications, life style changes, physical therapy, acupuncture, nerve stimulators and avoiding common triggers (like bright lights, certain foods, or loud sounds). for some patients, botox injected into the muscles of the forehead and neck can significantly reduce pain. unfortunately, this does not provide long-term relief as the effect of botox lasts for 3 months. since year 2000 surgery to treat a selected population of migraine patients has been gaining popularity and showing promising results. the surgery reduces the pressure on the peripheral nerves that are believed to cause migraine headaches by resecting the surrounding tissue (bone, fascia, muscle, and arteries). this surgery provides a more long-term and permanent relief. the purpose of this study is to follow the effectiveness and outcomes of migraine surgery.

migraines are very common and affect over 35 million americans a year. migraines can be painful and affect daily life. the cause of migraine is multifactorial and not completely understood. treatment usually includes different classes of medications, life style changes, physical therapy, acupuncture, nerve stimulators and avoiding common triggers (like bright lights, certain foods, or loud sounds). for some patients, botox injected into the muscles of the forehead and neck can significantly reduce pain. unfortunately, this does not provide long-term relief as the effect of botox lasts for 3 months. since year 2000 surgery to treat a selected population of migraine patients has been gaining popularity and showing promising results. the surgery reduces the pressure on the peripheral nerves that are believed to cause migraine headaches by resecting the surrounding tissue (bone, fascia, muscle, and arteries). this surgery provides a more long-term and permanent relief. the purpose of this study is to follow the effectiveness and outcomes of migraine surgery.

Eligibility criteria:
inclusion criteria: * 18 years or older * cleared by neurology and headache specialists for surgery * patient cleared by neurology for not having medication overuse headaches * patient able to localize a consistent trigger site where the migraines start * patient has been suffering from migraine for more than 2 years * botox injections or nerve blocks have worked for migraine relief in the past * patients formally diagnosed with migraine headaches by a neurologist * migraines impact quality of life per midas survey * no history of mania, bipolar disorder, major dispersive disorder, or suicidal ideation exclusion criteria: * high dose opioid medication use * does not meet criteria for migraine diagnosis * history of prior surgery for migraines
the effect of time-restricted eating combined with exercise training on body composition and cardiometabolic health

Conditions: Metabolic Syndrome

Summary: the aim of the study is to determine the effect of resistance training (rt) combined with time-restricted eating (tre) or normal diet (nd) on muscle mass, and strength. additionally, the study will compare between tre and nd and its effects on cardiometabolic health, mitochondria function and body composition among people with metabolic syndrome. in this randomized controlled trial, 50 males with metabolic syndrome (elevated waist circumference, blood pressure, triglycerides, fasting glucose and low high-density lipoprotein cholesterol) between the age of 40-60y and with bmi between 25-33 kg/m2 will be randomized to either tre+rt (n=25) or nd+rt (n=25). all participants will perform supervised and monitored rt three time per week for the 10 weeks of intervention study measurements; changes in body composition, muscle mass and adipose tissue distribution will be measured by 3-tesla magnetic resonance imaging (mri), dual energy x-ray absorptiometry (dxa), air displacement plethysmography (bodpod) and bioelectrical impedance analysis (bia). muscular strength will be assessed. blood samples, including lipid and glycemic profile. muscle biopsy taken from the vastus lateralis muscle.

primary aim. determine the effect of tre or nd, combined with rt training, on muscle mass and strength as adaptive response to 10 weeks of intervention among people with metabolic syndrome. secondary aims. determine the effect of tre combined with rt on cardiometabolic health lipid profile and hba1c (c), mitochondria function and oxygen consumption (d) and body composition assessment (e).

Eligibility criteria:
inclusion criteria: * subject with metabolic syndrome * bmi between 25-33 kg/m² * age 40-60 * without cardiac and pulmonary disease * did not engage exercise training in the last year. * willing and able to read, understand and sign an informed consent exclusion criteria: * participants that have cardiopulmonary disease * inability to attend scheduled clinic visits and/or comply with the study protocol * active smokers * previous regular exercise training in the previous yea * major orthopedic injury at the past 3 months * inability to perform an mri (due to claustrophobia, or metal in their body) * subjects that uses drugs that affect muscle metabolism

Keywords: time-restricted eating muscle mass strength cardio-metabolic risk