Kornimate/medical-research-clean huggingface dataset:
core strengthening vs pilates exercises on posture, body awareness and fatigue among female athletes

Conditions: Exercise Movement Techniques; Muscle Strength; Athletes; Posture

Summary: the study is randomized and single-blinded. ethical approval is taken from ethical committee of riphah international university, lahore. participants who meet the inclusion criteria will be enrolled and allocated in group a \& b through sealed envelope method by non-probability convenient random sampling technique. subjects in group a will receive core strengthening exercises. group b will receive pilates exercises.

the objective of the study is to determine the effects of core strengthening and pilates exercises on posture, body awareness, and fatigue among female athletes. the study is randomized and single-blinded. ethical approval is taken from ethical committee of riphah international university, lahore. participants who meet the inclusion criteria will be enrolled and allocated in group a \& b through sealed envelope method by non-probability convenient random sampling technique. subjects in group a will receive core strengthening exercises. group b will receive pilates exercises. york posture rating chart, body awareness scale, and modified fatigue impact scale will be done at the baseline and after the completion of treatment at 6 weeks. the data will be analyzed by spss, version 25. statistical significance is p=0.05.

Eligibility criteria:
inclusion criteria: * amateur female athletes 18-26 years of age, * duration of playing at least 6 months to 1 year, * bmi \<29 kg/m2, core training not less than 4 weeks, * females having no previous injury that could interfere with the study, * females are not currently using nutritional supplements exclusion criteria: * smoking, * sleeping medications, * complementary medicine use over the last six months, * stressful events in the past three months, * presence of a physical or mental illness, or surgical history, * presence of any neurological and vascular disease, * participants having another exercise program which can affect the results, * participants who are not able to participate in any regular exercise program.

Keywords: core strength pilates female athletes posture fatigue
treatment response of injectafer vs oral iron to baseline hepcidin levels in patients with iron deficiency anemia (ida) secondary to inflammatory bowel disease (ibd) or gastric bypass

Conditions: Iron Deficiency Anemia Secondary to IBD or Gastric Bypass

Summary: the primary objective of this study is to evaluate the treatment response of injectafer vs. oral iron to baseline hepcidin levels to determine if any of these select ibd or gastric bypass patients may demonstrate to be inappropriate for oral iron therapy.

the primary objective of this study is to evaluate the treatment response of injectafer vs. oral iron in patients with varying hepcidin levels correlating the treatment response/hepcidin levels to more common laboratory parameters such as ferritin and crp (c-reactive protein) levels and possibly determine if any of these select ibd or gastric bypass patients may demonstrate to be inappropriate for oral iron therapy.

Eligibility criteria:
inclusion criteria: * signed informed consent * male or female subjects ≥ 18 years of age with clinical diagnosis of ida secondary to ibd or gastric bypass * screening hemoglobin (hb) ≤ 11g/dl * screening ferritin ≤ 100 ng/ml * female subjects who are of childbearing age must have a negative pregnancy test at screening and be practicing an acceptable method of birth control during the study exclusion criteria: * hypersensitivity reaction to any component of iv injectafer or oral iron * requires dialysis for treatment of chronic kidney disease (ckd) * during the 30 day period prior to screening has been treated with iv iron * no evidence of iron deficiency * during the 30 day period prior to screening has been treated with a red blood cell transfusion. * any non-viral infection * known positive hepatitis with evidence of active disease * received an investigational drug within 30 days of screening * active malignancy within 5 years. basal or squamous cell skin cancer is not exclusionary * alcohol or drug abuse within the past 6 months * hemochromatosis or other iron storage disorders * pregnant * any other laboratory abnormality, medical condition, or psychiatric disorders which in the opinion of the investigator would put the subject's disease management at risk or may result in the subject being unable to comply with the study requirements
question prompt list for orthopaedic conditions

Conditions: Tendon Injuries; Fracture; Arthritis; Sprains; Strains; Tumor; Pain

Summary: the purpose of this study is to investigate whether providing patients with a question prompt list (qpl) prior to their orthopaedic surgery clinic appointment improves their perceived involvement in care (pics) score compared to being given 3 questions from the askshareknow model


Eligibility criteria:
inclusion criteria: * common orthopaedic condition new patient exclusion criteria: -
analysis of ocular surface microbiota in dry eye patients after femtosecond laser-assisted in-situ keratomileusis (fs-lasik)

Conditions: Refractive Surgery

Summary: by using 16s rrna sequencing technology to analyze the changes in ocular surface microbiota before and after surgery, as well as the impact of changes in ocular surface microbiota on fs-lasik induced des, new treatment ideas are provided for corneal fs-lasik induced des patients, and the incidence of fs-lasik related des is reduced.

this study aims to include 160 postoperative patients, who will be divided into a dry eye group and a normal group based on postoperative dry eye examination. microbial samples of the patient's conjunctival sac will be collected, and changes in the ocular surface microbiota before and after surgery will be analyzed using 16s rrna sequencing technology. the impact of changes in the ocular surface microbiota on fs-lasik induced des will also be analyzed, providing new treatment ideas for fs-lasik induced des patients and reducing the incidence of fs-lasik related des.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years old; 2. stable refractive index (refractive index change less than 0.5d in the past 2 years); 3. the best corrected far vision (cdva) is 1.0 or better; 4. postoperative dry eye patients need to meet the following criteria: patient's eye surface disease index (osdi) ≥ 13 and two of the following three criteria are met: tear film rupture time (but) ≤ 10s schirmer i test (mm/5min) ≤ 10mm, corneal fluorescein sodium staining exceeding 5 spots; exclusion criteria: 1. history of eye trauma or surgery; 2. suspected keratoconus; 3. previously suffering from other eye diseases such as keratitis or edema, glaucoma, uveitis, retinal detachment, macular degeneration, cataracts, amblyopia, etc.; 4. preoperative history of severe dry eye disease; 5. patients with systemic diseases, such as hyperthyroidism or autoimmune diseases; or severe mental disorders, such as anxiety and depression;
⁶⁸ga-dpa in the lung cancer diagnosis

Conditions: Lung Cancers

Summary: in previous studies, we synthesized a pd-l1-targeted molecular probe, ⁶⁸ga-dpa, and developed a ⁶⁸ga-dpa injection for clinical research. preliminary studies demonstrated its favorable safety profile and excellent imaging performance. leveraging the established strengths of the department of nuclear medicine at peking union medical college hospital, we now plan to conduct an exploratory pet/ct imaging study in lung cancer patients. this study aims to provide an in vivo, non-invasive, and visualizable technique for detecting pd-l1 expression levels and spatial distribution in tumors. it will further validate the clinical utility of this technology, offering critical diagnostic insights for initial assessment and treatment efficacy evaluation in pd-l1-positive tumor patients undergoing pd-l1-targeted therapies.


Eligibility criteria:
inclusion criteria: * age ≥18 years, regardless of gender. * patients clinically confirmed or suspected of lung cancer, with pathological specimens obtainable via biopsy or surgery within the recent 2 months. * at least one measurable target lesion according to response evaluation criteria in solid tumors (recist) v1.1. * expected survival \>3 months. exclusion criteria: * severe hepatic or renal dysfunction (serum creatinine \>3.0 mg/dl or any liver enzyme level ≥5× upper limit of normal). * women who are planning pregnancy, pregnant, or breastfeeding. * inability to lie supine for 30 minutes. * claustrophobia or other psychiatric disorders. * intolerance to any clinical procedures in the study. * other conditions deemed ineligible by the investigator.

Keywords: pd-l1 lung cancer pet/ct
exercise and overnight motor sequence task

Conditions: Schizophrenia and Related Disorders; Psychotic Disorders

Summary: the objective of this randomized controlled trial (rct) is to compare the changes of the sleep-related memory functions in patients with psychosis after they have completed the 12-week high-intensity exercise intervention, the 12-week low-intensity exercise intervention, or the 12-week controlled non-exercise intervention respectively. fifty-one patients with psychosis, patients who received either the high-intensity exercise or low-intensity exercise as intervention shown a significant improvement to their impaired sleep-related memory function, while those who received non-exercise intervention has no such improvement. moreover, high-intensity exercise may have a more prominent effect compare to low-intensity exercise.


Eligibility criteria:
inclusion criteria: * aged from 18 to 55 * based on the scid diagnosed to have schizophrenia and related psychotic disorders * ability to understand the nature of the study and to give written informed consent exclusion criteria: * severe physical illness (myocardial infarction, hypertension, fracture, spinal problems in which exercise may be contraindicated), and seizure disorders * comorbid substance dependence * unstable psychotic symptoms * a history of brain trauma or organic brain disease * known history of intellectual disability or special school attendance * answered one or more "yes" in the par-q and without doctors approval for exercise

Keywords: exercise sleep-dependent memory consolidation aerobic anaerobic
bulbar function in neuromuscular patients

Conditions: Neuromuscular Diseases

Summary: the main objective is prospectively study the upper airways function in an adult population of neuromuscular patients. the main measurement will be the evolution of tongue strength recorded each year during annual clinical evaluation on a 5 years period.

the main objective is to study the function of the superior airways (tongue and pharynx) in an non invasive way in neuromuscular patients followed in the home ventilation unit of the raymond poincare hospital (myopathy, neuropathy, disease of the neuromuscular junction or anterior horn) or of necker hospital and to detect prematurely the bulbar dysfunction. the secondary objectives of this prospective monocentric observational physiopathological study are: 1. to study the correlation between the possible swallowing dysfunction and the anomalies of the respiratory parameters 2. to establish correlations between infraclinical or clinical and presence of morphological tongue anomalies detected by magnetic resonance imaging like in acid maltase deficiency. the maximal tongue strength protrusion will be measured according to a method already used in the laboratory to explore sleep apnea syndromes. swallowing will be estimated by a non invasive method already used to highlight swallowing disorders in neurological and muscular pathologies this method will be associated with a method of recording of thoracic and abdominal movements. data wil be compared to a control database obtained for a previous study

Eligibility criteria:
inclusion criteria: * neuromuscular disorder * age greater than or equal to 6 * hospitalization in home ventilation unit - written informed consent exclusion criteria: * patient's refusal to participate * major swallowing disfunction * acute respiratory failure * no affiliation to social security

Keywords: tongue strength neuromuscular swallowing
coping skills for patients with chronic obstructive pulmonary disease (copd) and their caregivers

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this study is an nih-funded clinical trial conducted at duke university medical center and ohio state university. the purpose of this study is to examine the effects of a telephone-based, care-giver assisted, coping skills training (cst) program in patients with chronic obstructive pulmonary disease (copd) and their caregivers. this may help copd patients and their caregivers to deal better with the stress of lung disease. this study will test 3 primary hypotheses: 1) that enhanced cst will be more effective in improving quality of life compared to a usual medical care plus copd education and symptom management control group; 2) that enhanced cst will be associated with better medical outcomes (i.e., greater survival and fewer copd-related physician visits or hospitalizations) compared to controls over a follow-up period of up to 4 years; and 3) that improvements in quality of life and survival will be mediated by increased functional capacity and better coping. this proposed study builds upon our prior research by: a) adapting and refining our cst protocol, which was effective in improving psychosocial adjustment in patients awaiting lung transplantation, to a broader population of patients with copd who are not immediate candidates for lung transplantation; b) enhancing our intervention to improve functional capacity, reduce somatic symptoms, and improve survival; c) examining the impact of cst on medical expenditures; and d) including caregivers in an enhanced cst intervention.

overall, 746 participants (patients and caregivers) were consented for participation into this study from both duke university medical center and ohio state university. of these, 326 patients were randomized and participated in the study intervention along with 252 consented participants who acted as a caregiver; in total 578 participants (patients and caregivers) were involved with the study intervention.

Eligibility criteria:
inclusion criteria: * male or female outpatients 21 years of age or older * a diagnosis of copd * fev1 25%-80% of predicted value * fev1/fvc \<70% * capacity to give informed consent and follow study procedures exclusion criteria: * dementia * psychotic features including delusions or hallucinations * acute suicide or homicide risk * other illness (e.g., cancer) that is likely to cause death within 3 years * unstable angina * congestive heart failure stage iii - iv by nyha classification * active involvement in pulmonary rehabilitation or a formal exercise program

Keywords: lung disease chronic bronchitis emphysema caregiver stress copd chronic obstructive pulmonary disease
dermatological evaluation of topic compatibility-dermacyd tina gel sweet flower

Conditions: Hygiene

Summary: the purpose of this study is to demonstrate the absence of irritation potential (primary dermic irritability and cumulated dermic irritability) and allergy (sensibilization) of the product dermacyd tina gel sweet flower.


Eligibility criteria:
inclusion criteria: * phototype skin i,ii, iii e iv * integral skin test in the region exclusion criteria: * lactation or gestation * use of antiinflammatory and/or immunosuppression drugs * personnel history of atopy * history of sensitivity or irritation for topic products * active cutaneous disease * use of new drugs or cosmetics during the study the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
sunitinib drug levels and outcomes in kidney cancer

Conditions: Renal Cell Carcinoma

Summary: sunitinib is an oral drug used for treatment of advanced kidney cancer. the standard dose is 50mg, but many patients require a dose decrease due to side-effects. drug levels of sunitinib vary approximately 10-fold between patients. this study will measure blood levels of sunitinib and its metabolite, and correlate these with side-effects and the response to the treatment. the study aims to establish whether blood levels change with time, and see how useful blood levels are for monitoring patients treated with sunitinib.

rationale: sunitinib is an oral multi-targeted tyrosine kinase inhibitor used for first-line systemic therapy in metastatic renal cell carcinoma. it is metabolised to a pharmacologically active metabolite, su012662, which is of equal potency to the parent compound. at a standard 50mg daily dose, variability in plasma levels between patients is approximately ten-fold. in clinical trials, over 30% of patients require a dose reduction due to toxicity. however, some patients can tolerate up to 100mg without excessive toxicity. it is unknown if sunitinib clearance changes with time. pre-clinical experiments observed tyrosine kinase inhibition at a plasma concentration of 50-100ng/ml. design: this is a prospective non-randomized, phase ii clinical study. decision to treat patients with single-agent sunitinib is pre-determined by treating specialists before entering this study. toxicity and trough sunitinib/metabolite levels will be measured every six weeks during treatment. aim: this study will prospectively examine the relationship between steady-state trough levels of sunitinib/metabolites and the time on treatment, in addition to changes in trough levels over time. trough levels will also be correlated with other measures of efficacy and treatment-related toxicity. furthermore, we aim to confirm that the putative target of 50ng/ml correlates with toxicity and time on sunitinib.

Eligibility criteria:
inclusion criteria: * metastatic renal cell cancer treated with single agent sunitinib * no known primary liver disease and no other severe or uncontrolled concurrent medical conditions * signed informed consent exclusion criteria: * patients who are unable to sign informed consent * patients unable to give blood * patients who are pregnant, nursing or not using an effective contraception method * patients who had bone-marrow-transplantation prior to sunitinib treatment

Keywords: sunitinib renal cell carcinoma therapeutic drug monitoring pharmacokinetic treatment toxicity
first observatory of precocious puberty.

Conditions: Puberty, Precocious

Summary: the age of puberty has fluctuated throughout history. recent data shows an increase in the age of onset of puberty signs, in the united states but also in europe. a recent public health france study published in 2018 reports an increase in the incidence of precocious puberty with geographical heterogeneity. the consequences of these appearances include the early onset of menarche, short adult height and the psychological impact. due to a lack of studies and additional data, the reasons for this development are difficult to understand. among current hypotheses, the entanglement with the evolution of our environment is at the forefront: the action of environmental endocrine disruptors and nutritional factors could play a role in the process of early appearance of pubertal signs. the establishment of a national observatory for early and advanced puberty in collaboration with pediatric endocrinologists (on the front line) would allow a reliable and precise field approach, capable of supplementing epidemiological data, which are currently insufficient. the investigators hypothesize that the establishment of an observatory of pubertal advances (early puberty and advanced puberty) in private medicine is possible, with inclusion of at least 75% of eligible patients, and collection of at least 80% of data.


Eligibility criteria:
inclusion criteria: precocious puberty group (pp) : * suspected precocious puberty (girl aged \< 8 years or boy aged \< 9 years when the first signs of development\* appear) * suspected precocious puberty (girl aged \< 8 years or boy aged \< 9 years when the first signs of development\* appear) advanced puberty group (ap) : * suspected advanced puberty (girl aged ≥ 8 and \< 10 years or boy aged ≥ 9 and \< 11 years when the first signs of development\* appear) * first consultation with the investigator (pediatric endocrinologist). control group : * boy or girl without signs of pubertal development (tanner 1); * matched to the pp group on sex and age (+/- 1 year); * consultation with the same investigator over the same period (same quarter) as a patient in the pp group exclusion criteria: all groups * consultation with the same investigator over the same period (same quarter) as a patient in the pp group * family not speaking french, language barrier.

Keywords: early/precocious puberty advanced puberty national observatory private medicine feasibility
influence of modern colon hydrotherapy on intestinal transit

Conditions: Constipation - Functional; Hydrotherapy; Functional Colonic Diseases

Summary: a randomised and controlled trial, in which the effect of modern colon hydrotherapy is evaluated in the gastrointestinal transit of subjects with functional constipation

the aim of the present randomized randomised and controlled trial is to evaluate the effect of modern colon hydrotherapy in the gastrointestinal transit of subjects with functional constipation. two intervention groups were used, to which this type of treatment was applied and to which the intake of a product with prebiotic and prebiotic properties or a placebo was added, depending on the assigned group.

Eligibility criteria:
inclusion criteria: * patients between 20 and 60 years of age with functional constipation of more than 5 years of evolution. exclusion criteria: * taking any type of antibiotic in the last month * taking prebiotics or probiotics products in the last month. * taking laxatives in the last month. * undergoing any medicinal treatment * pregnancy * subject with a history of current gastrointestinal pathology or disorder such as: acute colon pathology, acute haemorrhagic colitis, suspected digestive perforation, recent abdominal surgery, severe arterial hypertension, abdominal hernia, colon neoplasia, history of cardiac syncope, renal failure, liver cirrhosis, epilepsy, severe psychiatric illness (psychosis), necrosis due to abdominal irradiation, severe anaemia, severe neurovegetative lability.

Keywords: constipation internal hydrotherapy radiopaque media functional colonic diseases
a predictive nomogram for trismus after radiotherapy for head and neck cancer

Conditions: Trismus

Summary: background: the aim of this study is to develop a prediction model for radiation-induced trismus (maximal interincisal distance equal to or less than 35 mm) based on a multivariable analysis of dosimetric and clinical factors.

the maximum inter-incisal opening (mio) of hean and neck cancer (hnc) patients who undergo radiotherapy (rt) ± concurrent chemotherapy with radical intent, will be prospectively measured prior to rt (baseline) and 6 months post-rt. the potential risk factors (clinical and dosimetric) will be first screened by univariate analysis and then by multivariate analysis. at the end of this process, the features identified as relevant, will be used to fit a logistic regression model and calculate the probability of observed trismus during the 6-month follow-up after rt

Eligibility criteria:
inclusion criteria: * hnc * treatment definitive or postoperative external beam radiotherapy, either alone or in -combination with chemotherapy or cetuximab at least 6 months follow-up exclusion criteria: * primary tumor out-side the head and neck region, intracranially, or if it originated from the nasal vestibule * patient death during rt or within the first 6 months after the start of rt, no outcome data available

Keywords: radiation induced trismus, head and neck radiotherapy