Kornimate/medical-research-clean huggingface dataset:
integration of the therapeutic workplace in drug court

Conditions: Drug Addiction

Summary: drug courts were developed as a therapeutic alternative to incarceration of drug-involved offenders by providing 'judicially supervised' drug abuse treatment and probation for nonviolent offenders in lieu of criminal prosecution and incarceration. outcome studies have shown that drug courts have modest effects on participation in drug abuse treatment, drug use, and employment. the therapeutic workplace intervention is an effective employment-based treatment that integrates abstinence reinforcement contingencies in a work setting, intended to treat individuals with histories of drug addiction and chronic unemployment. under this intervention, drug abuse patients are hired and paid to work. to promote abstinence, patients are required to provide drug-free urine samples to gain and maintain daily access in the workplace. in this way, patients can work and earn salary, but only as long as they remain drug abstinent. patients using drugs and lacking job skills participate in an initial training phase to initiate abstinence and establish computer data entry skills. once abstinent and skilled, patients are hired into an income-producing therapeutic workplace data entry business. given that many drug court participants suffer from long histories of drug addiction and unemployment, the therapeutic workplace could be ideal for this population. this proposes of this clinical trial is to evaluate the therapeutic workplace intervention in a drug court.


Eligibility criteria:
inclusion criteria: * enrolled in drug court * report using any opiates and/or cocaine during 30 days prior to their arrest * unemployed exclusion criteria: individuals are excluded if they: * are at imminent risk of suicide * have a psychotic disorder that may limit their workplace functioning or their ability to provide informed consent

Keywords: cocaine addiction, treatment, contingency management, employment intervention
a facebook intervention for young sexual and gender minority smokers

Conditions: Tobacco Use; Smoking; Tobacco Dependence; Tobacco Use Disorder; Tobacco Use Cessation; Tobacco Smoking; Smoking Cessation; Smoking, Cigarette; Smoking, Tobacco

Summary: the 2-year research plan will test the put it out project (pop) in a pilot randomized trial (n=120) compared to tsp and two historical control conditions. participants will be young adults who smoke, identify as sexual or gender minorities, and use facebook. the primary outcome will be biochemically verified 7-day abstinence from smoking at 3 and 6 months. secondary outcomes will be a quit attempt (y/n), stage of change, and thoughts about tobacco abstinence at 3 and 6 mos.

participants will be randomized to one of two conditions: (1) a facebook-delivered intervention addressing tobacco use, tailored to sgm young adults; or (2) a 3-month facebook intervention targeting tobacco use. both interventions will include 90 days of facebook-based messages and activities tailored to participants' readiness to quit smoking. assessments will occur at baseline, 3, and 6 months follow-up. assessments will include measures on smoking, thoughts about abstinence, and sgm identity experiences. all participants who report no past 7-day smoking will be asked to give biochemical verification of smoking status with saliva cotinine test kits that will be mailed to participants.

Eligibility criteria:
inclusion criteria: * read english * between 18 and 25 years of age * indicate they use facebook "most" (≥ 4) days per week * have smoked ≥100 cigarettes in their lives and currently smoke at least 1 cigarette per day on 4 or more days of the week * identifies as sgm exclusion criteria: * do not read english * are not between 18 and 25 years of age * indicate they do not use facebook "most" (≥ 4) days per week * have not smoked ≥100 cigarettes in their lives and currently smoke at least 1 cigarette per day on 4 or more days of the week * does not identify as sgm

Keywords: tobacco gender identity minority sexual identity minority cessation intervention young adults social media internet cigarette
risk factors for polypharmacy in older adults

Conditions: Polypharmacy

Summary: patients who were 65 years old or older and applied to melek hatun family practice center were enrolled in the study. all patients were seen either in our center or in their homes, and informed consents were obtained. comprehensive geriatric assessment (cga) was performed for each subject. data were evaluated by pasw 17. the amount of medicines that the patient used everyday (ddc) was dependent variable. relationships between ddc and other continuous variables were examined by pearson's correlation. for categorical independent variables, t-tests were performed.

1000 patients who were 65 years old or older and applied to melek hatun family practice center either in person or through a relative between 01 december 2014 and 01 august 2017 were enrolled in the study. all patients were seen either in our center or in their homes, and informed consents were obtained. comprehensive geriatric assessment (cga) consisting of detailed history and examination, drug consumption information, body mass index (bmi), waist circumference (wc), timed up \& go test (tug), clock drawing test (cd), activities of daily living and instrumental activities of daily living scales (adl \& iadl), mini mental state examination (mmse), tinetti gait and tinetti balance scores (tg \&tb), 30 items geriatric depression scale (gds) was performed for each subject\[8-16\]. additional tests like blood examinations or ecg were performed on the basis of necessity. metabolic syndrome (ms) was diagnosed according to who criteria \[17\]. data were evaluated by pasw 17. the amount of medicines that the patient used everyday (daily drug consumption-ddc) were dependent variable. relationships between ddc and other continuous variables were examined by pearson's correlation. for categorical independent variables, t-tests were performed. the variables which were found associated with ddc were controlled for confounding variables by linear regressions. to avoid collinearity problems, variables that were strongly interrelated (like cd and mmse) were not added to the regression model together. for all analyses, the level of significance was assumed as 0.05.

Eligibility criteria:
inclusion criteria: * patients of 65 exclusion criteria: * patients under 65 years * patients who do not want to participate in the study

Keywords: comprehensive geriatric assesment, polypharmacy,geriatric depression scale,neutrophil/lymphocyte ratio
dried purple laver (nori) as a food source of vitamin b12 in vegetarians

Conditions: Vitamin B 12 Deficiency

Summary: this is an intervention study aiming to understand the bioavailability of vitamin b12 from nori for vegetarians.

thirty vegetarian participants will be randomly assigned to one of three intervention arms: (1) 5g of nori (4 sheets, containing 2.4μg vitamin b12), (2) 8g nori (7 sheets, containing 4μg vitamin b12), (3) control group (no nori). at baseline and end of 4 weeks, participants will be measured on serum vitamin b12, methylmalonic acid, holotranscobalamin, homocysteine and folate.

Eligibility criteria:
inclusion criteria: * vegetarians (including vegan, ovo-vegetarian, lacto-vegetarian, lacto-ovo vegetarian) * duration of the vegetarian diet: at least 1 year * aged 20-60 years old * have not taken vitamin b12 or folate supplement within 1 year * willing to adhere to study intervention and be tested for vitamin b12 related biomarkers. * familiar with line application on smartphone exclusion criteria: * any disease or surgery that affects the vitamin b12 status (pernicious anemia, gastrointestinal disease and surgery, pancreatic diseases, chronic kidney disease) * hyperthyroidism * previous adverse reaction to nori * have taken antacid or metformin in the past 1 week * alcoholic and not willing to abstinence from alcoholic beverages

Keywords: vitamin b12 vegetarian diet purple laver (porphyra sp.) nori
non-isotope based imaging modalities vs technetium-99m single-photon emission computed tomography(99mtcspect)

Conditions: Myocardial Ischemia

Summary: spect is currently the dominant clinical test for diagnostic and prognostic purposes as well as therapeutic decision-making. given the shortage of nuclear reactor-produced tc, advancing the use of non-isotope based imaging modalities has the potential to change the standard of care for patients with cad as each one of these technics (cmr, ct, stress echocardiography) has its own distinct potential advantages over spect.

obtain a better understanding of the clinical utility of advanced non-isotope-based imaging modalities to detect relevant cad as potential alternatives to spect. approximately 450 subjects will be enrolled in total. three groups of about 150 patients per group. each group will undergo imaging with 2 modalities; group 1: 99mtcspect plus cmr, group 2: 99mtcspect plus ct, group 3:99mtcspect plus stress echocardiography. all 450 patients will undergo standard invasive coronary angiography following completion of non-invasive imaging, except for patients in whom both nuclear and non-nuclear imaging modalities reveal a normal result confirming the absence of significant coronary artery disease (i.e invasive angiography would not be clinically indicated and ffr would be considered to be above 0.8). thrombolysis in myocardial infraction (timi) flow will be measured in all patients undergoing angiography, and fractional flow reserve (ffr) will be measured in all patients except those with timi flow =0, 1 and 2. all imaging procedures must be completed within 6 weeks. all patients will have a follow-up visit at 6 months after enrollment. during the 6 month follow-up visit major adverse cardiovascular events will be collected and adjudicated by a clinical endpoint committee (cec).

Eligibility criteria:
inclusion criteria: * clinically indicated request for spect * ability to undergo at least one of three non-nuclear imaging tests; cmr, ct or stress echocardiography * history of recent symptoms suggestive of myocardial ischemia * high risk for ischemic cardiovascular events exclusion criteria: * severely reduced systolic function (lv ejection fraction less than 35%) * recent (less than 3 days) acute coronary syndrome including acute myocardial infarction * contraindications to dipyridamole spect including : i)severe reactive airway disease; ii) less than 3 days post myocardial infarction - acute coronary syndrome (mi-acs); iii) high-grade atrioventricular block (av block); iv)allergy to dipyridamole or theophylline; v) caffeine within 12 hours; vi) theophylline use within 48 hours; vii) severe claustrophobia; or viii) women who may be pregnant * kidney dysfunction (i.e estimated glomerular filtration rate (egfr) less than 45) * use of investigational drug or device within 30 days of screening visit * coronary artery bypass graft(s) surgery (cabg)

Keywords: spect cmr high risk for ischemic cardiovascular events
comparison of antinociceptive effects of ketamine and magnesium used for sedation in hysteroscopy cases

Conditions: Hysteroscopy

Summary: this study aims to compare the antinociceptive effects of ketamine and magnesium used in addition to midazolam, fentanyl, propofol and remifentanil agents preferred in hysteroscopy cases. it is conducted to observe the effect of ketamine and magnesium use on total additional propofol doses and additional remifentanil doses.

sedation is generally preferred in hysteroscopy cases. the most commonly used intravenous drugs are midazolam, fentanyl, propofol and remifentanil. multimodal analgesia, which is intended to be provided in hysteroscopy cases, is a strategy that includes the use of two or more analgesic agents and techniques to provide adequate analgesia; and aims to minimize side effects such as bradycardia, hypotension, respiratory depression, pruritus, and postoperative nausea and vomiting. multimodal analgesia improves patient and surgical comfort by applying additional drugs to existing agents, reduces postoperative complications, and thus helps to shorten hospital stays and reduce costs. whether magnesium contributes to this multimodal analgesia will be investigated observationally, based on its antinociceptive effects.

Eligibility criteria:
inclusion criteria: 1. asa i-ii patients 2. patients aged 18-55 3. patients undergoing hysteroscopy exclusion criteria: 1. patients who develop surgical complications during hysteroscopy 2. patients with cardiovascular failure (ejection fraction \<40%, patients with atrioventricular conduction disorder 3. patients with history of cerebrovascular disease 4. liver dysfunction (transaminases above normal level), renal failure (creatine \> 150 μmol/l), 5. preoperative opioid use 6. history of neuromuscular disease 7. history of drug or alcohol abuse 8. patients who develop the need for endotracheal intubation

Keywords: magnesium sedation hysteroscopi opioid pain
the effect of tongue cleaning in periodontitis patients

Conditions: Periodontitis; Tongue Coating

Summary: the aim of this study was to examine in periodontitis patients with visible tongue coating the changes in microbial load (aerobic and anaerobic) of the 14 day use of a tongue scraper versus the use of a regular toothbrush to clean the tongue.

volatile sulphur compounds (vsc's) are the most important causes of bad breath. since the micro-organisms that produce vsc's are also periodopathogens, intuitively, one would think that there is a positive correlation between vsc levels in exhaled breath and periodontitis. however, not all periodontitis patients have bad breath. a possible explanation can be a positive relationship between tongue coating an bad breath. in the past, tongue cleaning was already researched in an oral healthy population. this research aimed to examine in periodontitis patients with visible tongue coating the changes in microbial load (aerobic and anaerobic) of the 14 day use of a tongue scraper versus the use of a regular toothbrush to clean the tongue. additionally changes in tongue coating; and patient perception about tongue cleaning was researched.

Eligibility criteria:
inclusion criteria: * systemically healthy patients * periodontitis patients exclusion criteria: * already using a tongue cleaning device * use of antibiotics the previous 6 months * rinsing with a chlorhexidine mouth rinse the past month * smokers * patients who underwent periodontal therapy the past three years were not included.

Keywords: periodontitis tongue coating tongue cleaning bacterial load
key circrna identification of postoperative delirium in elderly patients undergoing cardiac surgery

Conditions: Postoperative Delirium

Summary: the observational study aims to discover differentially expressed circrnas in the peripheral blood of patients with postoperative delirium, which aims to answer the main questions at: whether there are changes in circrna expression in peripheral blood in elderly patients with delirium after cardiopulmonary bypass surgery? whether the circrna with altered expression plays an important role in the occurrence and development of pod? what are the functions and underlying mechanisms of circrna with altered expression in pod? voluntary patients will receive follow-up 1 day before and 7 days after surgery to assess their cognitive function, and peripheral blood will be collected 1 day before and 3 days after surgery. the study divided patients into pod group and non-pod group according to whether delirium occurred within 7 days after surgery.

investigators combined qrt-pcr by performing circrnas chip analysis to study differential expression of circrnas in plasma samples of elderly patients with non-pod who underwent cardiac surgery under general anesthesia and cardiopulmonary bypass. subsequently, mirna binding sites and associated mrnas are predicted by bioinformatics analysis. moreover, we plan to construct predicted circn-mirna-mrna co-expression networks to study the main functions and pathways of target genes, thereby attempting to provide a preliminary view of the potential role of a circrna in pod. the study may provide an important perspective on the differential expression of circrna in patients with pod, and may also provide insights into biomarkers and therapeutic targets of pod.

Eligibility criteria:
inclusion criteria: 1. be over 50 years old; 2. asa grade i-iii; 3. heart surgery is planned under general anesthesia. exclusion criteria: 1. patients with the second surgery; 2. the ejection fraction is less than 40%; 3. the score of the preoperative simple mental status examination (mmse) is less than 24 points; 4. patients with mental illness or central nervous system disease; 5. patients who cannot or refuse to complete mmse before surgery.
renal sympathetic modification in patients with chronic renal failure

Conditions: Chronic Renal Failure

Summary: the purpose of this study is to observe the incident of uremia and dialysis requirement after renal sympathetic modification using thermocool® catheter in patients with chronic renal failure, and evaluate safety and efficacy of the intervention.

chronic renal failure is serial clinical manifestations because of kidney damage. previous studies found sympathetic nerves over activity in chronic renal failure patients. traditional therapies included medications and dialysis replacement therapy need to spend much money. renal ablation for sympathetic modification is a new method which is proved to be effective in decreasing sympathetic nerves activity. we assume that modifying renal sympathetic activity by ablation is effective and safe in treatment of chronic renal failure. this trial is going to recruit 200 patients (ablation group vs control group = 1:1) with a follow-up duration of 3 years. patients in ablation group will receive additional necessary medications besides expectant intervention, and patients in control group will receive appropriate medications only. we aim to observe the effect of serum creatinine, creatinine clearance rate, glomerular filtration rate, urine microalbumin, urine microalbumin/creatinine, and composite cardio cerebrovascular events after renal sympathetic modification using thermocool® catheter, and evaluate safety and efficacy of the intervention.

Eligibility criteria:
inclusion criteria: * ≥ 18 years old, and ≤ 75 years old of age * at least three months history of definite kidney damage * renal function of serum creatinine of \< 354umol/l, and/or creatinine clearance rate of ≥ 30ml/min, and/or estimated glomerular filtration rate of ≥ 45ml/min for recent 2-3 times evaluation. besides, the value of creatinine clearance rate fluctuated no more than 30% in recent three months, and 15% in the following two weeks. * urine microalbumin, and/or urine microalbumin/creatinine is abnormal, and/or quantity of 24 hrs urine protein suggests kidney damage. * is competent and willing to provide written, informed consent to participate in this clinical study exclusion criteria: * congenital renal diseases cause to chronic renal damage * estimated glomerular filtration rate (egfr) of \< 45ml/min * taking medicine of glucocorticosteroids, non-steroid anti-inflammatory drugs (nsaids), or cytotoxic drugs at present * value of 24 hrs urine protein is of \> 10g at least once in recent three months, or serum albumin of \< 25g/l * has the history of renal restenosis or renal stents implantation * has experienced ami (old myocardial infarction is not excluded), unstable angina pectoris, cerebrovascular accidents, and alimentary tract hemorrhage within 3 months * carcinoma patients * patients with sick sinus syndrome * pregnant women * mental disorders * patients that have allergy to contrast agent * patients that do not go with follow-up * others such as researcher considers it is not appropriate to be included into the study

Keywords: renal artery sympathetic nerves modification chronic renal failure
glucose testing in gdm: adherence to one- versus two-hour postprandial glucose monitoring in gestational diabetics

Conditions: Gestational Diabetes

Summary: the purpose of this study is to evaluate if in patients with gestational diabetes (gdm), adherence to postprandial glucose monitoring differs when performed 1-hour versus 2-hours after eating. the primary objective of this study is to evaluate difference in rate of adherence (binary outcome defined as \<80% or ≥80% of glucose log completed) between gestational diabetics who perform 1-hour versus 2-hour postprandial blood glucose testing.

consented patients who are diagnosed with gestational diabetes will be randomized to either 1-hour or 2-hour postprandial blood glucose monitoring. a retrospective chart review from july 2020 until study commencement for patients from the same clinic will be used as a historical control group. this study will assess differences in adherence to testing.

Eligibility criteria:
inclusion criteria: * pregnant patients with singleton gestation who are ≥ 18 years of age. * diagnosis of gdm after 24 0/7 weeks. * for diagnosing gdm, a two-step screening algorithm will be performed according to the american college of obstetrics and gynecologists.4 specifically, a 1-hour 50-g glucose-loading test is given first. plasma glucose levels between 140 and 200 mg/dl will be considered elevated. confirmatory testing will then be performed using a 3-hour 100-g glucose tolerance test. diagnosis was made when two of the four values were elevated. abnormal glucose value thresholds are established via the criteria suggested by carpenter and coustan: fasting value ≥ 95 mg/dl, 1-hour ≥ 180 mg/dl, 2-hour ≥ 155 mg/dl, and 3-hour ≥ 140 mg/dl.9 patients with a blood glucose level greater than 200 mg/dl after 1-hour 50-g glucose-loading test will be diagnosed with gdm without requirement for the 3-hour 100-g glucose tolerance test. exclusion criteria: * type 1 pre-gestational diabetes * type 2 pre-gestational diabetes * gdm diagnosed prior to 24 0/7 weeks gestation.
evaluation of performance of new ifis sleeve

Conditions: Cataract

Summary: a silicone sleeve will be used on the hydrodissection needle to avoid that the iris can prolaps through the gap between needle and incision wound.

cataract surgey is a common operation approximately 25 million pocedures per year worldwide. an essential step of the procedure is hydrodissection where fluid is forced into the eye through a cannula to free the cataract from its capsule. a serious and potential sight threatening complication of hydrodissection is iris prolapse, where the iris comes out of the wound. the overall incidence of iris prolapse during cataract surgery is 0.9% and higher in patients with intraoperative floppy iris syndrome (ifis) at 11.9% , small pupils and small eyes. patients on tamsulosin medication with a full set of project data iras version 6.3.3 5 draft pupil less than 7.5mm have a 79% risk of prolapse iris prolapse most often occurs during hydrodissection because the hydrodissection cannula is smaller (approx.1mm) than the wound (2.2-2.7mm) it is introduced through. therefore the iris can be forced out / prolapse through this gap by the forced injection of fluid. traditional methods such as phenylephrine injection into the eye have varying effects can be unlicensed and possibly increase the prolapse risk. mechanical pupil stretching can permanently damage the iris with complications. phacosleeve hydrodissection where the wound is sealed by a phacosleeve and the hydrodissecting irrigation cannula introduced through the sleeve or from side port /incison. the phacosleeve is not designed for this. this study is to use a purpose made tapered sleeve by medicel in the same fashion as the current phacosleeve.

Eligibility criteria:
inclusion criteria: * patient with planned cataract surgery exclusion criteria: * pregnant woman