Kornimate/medical-research-clean huggingface dataset:
shared responsibility between general practitioners and highly specialized hospitals in spinal cord injury

Conditions: Spinal Cord Injuries

Summary: it is an interventional study that aims to assess a new primary care model of collaboration between specialized centers and primary care physicians in switzerland, in order to reduce morbidity and improve patients' and providers' experience with delivery of follow-up care in individuals with chronic spinal cord injury as compared to current best practice.

this model will lead to awareness, recognition and interactive communication between gps and specialists and guidelines on the shared-role relationship. the study interventions are educational modules on bladder, bowel, skin-care, and pain management which will be provided to participating gps by spinal cord injury specialists. in addition visits by specialized nurses to the participating gps at their practices to support the establishment of specialized care on-site.

Eligibility criteria:
inclusion criteria: physicians * gps practicing in medium to large group practice * the practice is wheelchair accessible and remote to sci specialized centers * proficiency certificate in ultrasonography patients: * diagnosed with traumatic or non-traumatic, sensory or motor complete or incomplete, chronic sci * 18 years or older * permanently reside in switzerland * reside farther than 25 minutes driving distance from a specialized sci center * understand german, english, italian * informed consent * additionally in treatment group: patients with chronic sci living in the region of a participating gp irrespective if they visit the participating primary care practice. * additionally in control group: individuals with sci who live outside the catchment areas exclusion criteria: patients: - acute sci or during first rehabilitation phase - congenital conditions leading to paraplegia or tetraplegia, including spina bifida - neurodegenerative disorders such as multiple sclerosis and amyotrophic lateral sclerosis - guillain-barré syndrome
covid-19 epidemic and patients with myeloproliferative neoplasias

Conditions: Myeloproliferative Neoplasm; COVID-19 Infection

Summary: the classic myeloproliferative neoplasias (mnp), including polycythemia vera (pv), essential thrombocythemia (et), primary myelofibrosis (pmf) or secondary to pv or et, are among the most frequent of malignant hemopathies, with overall prevalence estimated at around 10,000 patients followed in france. due to the median age of patients around 65, the frequency of cardiovascular complications of these thrombogenic diseases and the impact of cytoreductive treatments on immune cells, these patients are considered to be at risk of developing forms severe of covid-19. this study will assess the impact of mnps on the risk of developing a severe form of covid-19, identify new risk factors linked to the disease as well as the impact of treatments for mnps according to their pharmacological class.

it is a descriptive, prospective epidemiological study using retrospective patient data, multicenter, non-interventional, carried out in fim (french intergroup of myeloproliferative syndromes) / filo (french innovative leukemia organization) centers. this is an exploratory descriptive study in order to put in place as soon as possible a possible strategy for the protection of patients most at risk. the study will include all consecutive patients with mnp according to the who (world health organization) classification seen in consultation or teleconsultation over the duration of the study, whether or not they have had a covid-19 infection. the collection of clinical data, treatment regimens and survival and death data will be carried out by the investigator or a member of his medical team, after delivering an information note to the patient informing him of the computerized processing of his data, subject to the patient's non-objection. the diagnosis of asymptomatic covid 19 will be made on the presence of a positive serology and on the absence of clinical signs on questioning. the presence of a symptomatic covid 19 infection will be posed on the presence of clinical signs +/- ct as identified by the practitioner who treated the patient and confirmed or not by a positive pcr and / or a positive serology. data collected: * socio-demographic data (gender, date of birth) * description of hemopathy and its treatment * description of covid-19 infection and its management * biological data: blood count, specific covid-19 test results if available (pcr, serology). * history, comorbidities * evolution of covid-19 infection and possible specific treatment

Eligibility criteria:
inclusion criteria: * patient with pv, et, pmf or mf secondary to pv or et diagnosed before the covid-19 pandemic * seen in consultation or teleconsultation from may 2020 or deceased if the investigator became aware of this death during the study period exclusion criteria: * refusal to participate in the study
edge computing platform for spine health risk management based on iot technology

Conditions: Cervical Disc Herniation; Cervical Spinal Stenosis; Ossification of Posterior Longitudinal Ligament; Neckbrace Device

Summary: this project proposes to monitor the spinal posture of a person at rest and in motion in real time through a sensor device that contains spinal health monitoring as its core. by calibrating the five core planes on the spine and using ai algorithms to train the model, the relationship between the core plane data and spine health is established.this project will output medical-grade and consumer-grade wearable spine healthcare and monitoring products, establish an interactive platform to connect the wearer, the data terminal and the professional medical team, so that patients can easily get professional health advice and reminders during home healthcare and rehabilitation; and through the collection of spine health data, establish a national spine health database.


Eligibility criteria:
inclusion criteria: * between the ages of 18 and 60 years. * degenerative diseases of the cervical spine such as cervical disc herniation, cervical stenosis, ossification of the posterior longitudinal ligament, etc., but surgery is not considered for the time being. * available for clinical follow-up and agree to long-term clinical follow-up and sign informed consent. exclusion criteria: * age less than 18 years or more than 60 years. * life expectancy less than 1 year. * suffering from severe dementia (mmse score less than 18). * suffering from other serious medical conditions. * inability to sign informed consent.

Keywords: rehabilitation neckbrace device cervical diesase
arj c13 urea breath test system

Conditions: H. Pylori Infection

Summary: an open-label, comparative group study to evaluate the equivalency of the pyloplus 13c urea breath test to predicate devices on the market.

an open-label, comparative group study to evaluate the equivalency of the pyloplus 13c urea breath test to predicate devices on the market. predicate devices include: histology, culture, rut, and other 13c breath tests.

Eligibility criteria:
inclusion criteria: * male or female at least 18 years of age at the time of visit * patients who are experiencing the effects of gastritis * written informed consent (and assent when applicable) obtained from subject and ability for subject to comply with the requirements of the study exclusion criteria: * pregnant or lactating women. * study subjects currently taking antibiotics * presence of a condition or abnormality that in the opinion of the investigator would compromise the safety of the patient or the quality of the data * fasting required one hour prior to testing * study subjects shall not consume the following items prior to the test: mouthwash, chewing gum, carbonated beverages, cigarette smoke, acetone (to stimulate the effect of ketone production that may result from some diets), alcohol
thousand asian american study

Conditions: Hepatitis B

Summary: the "thousand asian american study" or "taas" aims to test 2,000 foreign-born and children of foreign born asian americans residing in sacramento county residents for hbv and (2) counsel at least 90% of those whose screening results are positive for hbv.

the "thousand asian american study" or "taas" aims to better understand the factors associated with testing for hepatitis b viral (hbv) testing among foreign-born asian and african adult residents of sacramento county, characteristics of those infected with hbv, and the efficacy of follow-up and linkage to care for those infected with hbv, and develop a research platform for future studies. thus, what the investigators want to do is 1) test 2000 foreign-born sacramento county residents for hbv and (2) counsel at least 90% of those whose screening results are positive for hbv. the investigators want to better characterize factors associated with hbv testing and factors that may differentiate those determined to be free of infection, infected with hbv, and those with resulting primary liver cancer.

Eligibility criteria:
inclusion criteria: * all foreign-born asians and any foreign-born adults born in cdc-defined high to intermediate endemic areas residing in sacramento county, california. exclusion criteria: * individuals who have been previously serologically tested for hepatitis b (self-reported).
safety, tolerability and efficacy of qrx003 lotion in subjects with netherton syndrome

Conditions: Netherton Syndrome

Summary: this study has been designed to determine the safety, tolerability and efficacy of qrx003 lotion 2%, 4% qam or 4% bid in subjects with netherton syndrome (ns) in comparison to vehicle


Eligibility criteria:
inclusion criteria: * subject is a male or non-pregnant female at least 14 years of age. * females must be post-menopausal , surgically sterile , or use an effective method of birth control , for the duration of the study and for 3 months following completion of treatment. women of childbearing potential (wocbp) must have a negative urine pregnancy test (upt) at visit 1/screening and visit 2/baseline. * subject has a clinical diagnosis of ns and agrees to genetic testing at visit 1/screening for confirmation of ns diagnosis if the subject does not have test results confirming a spink5 mutation. * subject has ns lesions in the treatment area (i.e., arms or lower legs). * subject is in good general health and free of any disease state or physical condition that might impair evaluation of ns or exposes the subject to an unacceptable risk by study participation. exclusion criteria: * subject is pregnant, lactating, or is planning to become pregnant during the study. * subject has any skin pathology in the treatment area or condition that, could interfere with the evaluation of the test article or requires use of interfering topical, systemic, or surgical therapy. * subject has fridericia-corrected qt ≥ 450 ms for males or ≥ 470 ms for females * subject has active cancer of any type excluding non-melanoma skin cancer outside of the treatment area. * subject has diabetes of any type, except non-insulin dependent diabetes mellitus that is reasonably controlled. * subject has evidence of active infection during screening, or serious infection within 30 days prior to visit 2/baseline. * subject has known human immunodeficiency virus, hepatitis b or c virus, or active or latent tuberculosis. * subject has used ultraviolet phototherapy within the treatment area within 4 weeks prior to visit 2/baseline. * subject has used systemic prescription treatment for ns within 4 weeks prior to visit 2/baseline. * subject has used systemic biologic therapy for ns. * subject has used topical prescription treatment in the treatment area within 2 weeks prior to visit 2/baseline. * subject has used any topical bland moisturizers/emollients in the treatment area within 24 hours prior to visit 2/baseline. * subject is currently enrolled in an investigational drug, biologic, or device study. * subject has used an investigational drug, biologic, or device treatment within 30 days prior to visit 2/baseline.
effects of multimodal cognitive enhancement therapy (mcet) for ealy dementia

Conditions: Mild Cognitive Impairment; Dementia, Mild

Summary: this study evaluates the effects of multimodal cognitive enhancement therapy (mcet) for people with mild cognitive impairment and early stage dementia by a randomized, controlled (mock-therapy), double-blind, cross-over trial

multimodal cognitive enhancement therapy (mcet) was developed for cognitive rehabilitation of mild cognitive impairment or ealy dementia. mcet consists of cognitive training, cognitive stimulation, reality orientation, physical therapy, reminiscence therapy and music therapy that obtained 'a' grade of recommendation by sign(scottish intercollegiate guidelines network) for their efficacy (one of the followings: global cognition/specific cognitive domain/mood/activities of daily living/behavioral and psychological symptoms/quality of life) based on the systematic review and meta-analysis performed by our research team. this study investigated the efficacy of mcet compared with mock-therapy that consisted of random activities that were not based on clinical evidences (e.g., watching tv, conversation etc.).

Eligibility criteria:
inclusion criteria: * aged 55-90 * diagnosed to dementia by the diagnostic and statistical manual, fourth edition (dsm-iv) or to mild cognitive impairment by international working group on mild cognitive impairment * clinical dementia rating (cdr) of 0 or 0.5 for mild cognitive impairment, 0.5 or 1 for early dementia exclusion criteria: * evidence of current delirium, confusion * any acute neurological conditions (infectious or inflammatory disorders such as viral, fungal or syphilis) or acute medical conditions * current major psychiatric disorder by dsm-iv such as major depressive episode or manic or psychotic episode

Keywords: mild cognitive impairment dementia cognitive training cognitive rehabilitation cognitive therapy
regorafenib in indian patients with metastatic colorectal cancer (mcrc).

Conditions: Metastatic Colorectal Cancer

Summary: this is a phase iv, single-arm, prospective, open-label, multicenter, interventional study to evaluate safety and efficacy of regorafenib in patients with mcrc who have been previously treated with fluoropyrimidine , oxaliplatin-, and irinotecan based chemotherapy, an anti-vegf therapy, and, if ras wild type, an anti-egfr therapy.


Eligibility criteria:
inclusion criteria: * male or female patients (≥18 years of age) with metastatic (stage iv) colorectal adenocarcinoma confirmed either histologically or cytologically, with measurable metastatic disease according to recist v. 1.1 * patients must have pd after receiving the approved standard therapies * patients must have ecog ps of 0 or 1 and a life expectancy of at least 3 months * adequate bone marrow, liver and renal function * women of childbearing potential and men must agree to use adequate contraception exclusion criteria: * unresolved toxicity greater than grade 1 from prior treatment for mcrc * previous (within 28 days) or concomitant participation in another clinical study with investigational medicinal product(s) * subjects unable to swallow oral medications * any malabsorption condition * any medical or surgical conditions within 28 days before start of regorafenib that will interfere with patient's participation in the study

Keywords: mcrc
randomized controlled trial of a novel laser-aided orthodontic-periodontal treatment strategy

Conditions: Periodontal Disease

Summary: the aim of the study is to assess the effects of low-level laser therapy (lllt) in patients with periodontitis during orthodontic-periodontal treatment for 12 months on the following aspects: (1) effects on periodontal status; (2) effects on alveolar bone remodeling; (3) effects on cervical dentin sensitivity; (4) effects on pain and quality of life. to eliminate any bias, the investigators will initially hypothesize that there is no difference in periodontal status, jawbone remodeling, tooth sensitivity, pain and quality of life in patients having teeth with chronic periodontitis and receiving lllt with orthodontic treatment versus teeth undergoing orthodontic treatment without incorporation of lllt.

on the basis of the investigators' pilot study results, 35 patients with chronic periodontitis will be recruited and initially treated for inflammation. using a randomized split-mouth design,the teeth in experimental (laser) group will receive lllt while the teeth in the control (placebo) group will receive no laser treatment. the effects of lllt in orthodontic-periodontal treatment on periodontal inflammation control, jawbone remodeling, reduction of tooth sensitivity, pain relief and quality of life will be investigated.

Eligibility criteria:
inclusion criteria: 1. systemically health (with special regard to disease affecting tissue repair); 2. no medications required for periodontal therapy and no use of any antibiotic and/or anti-inflammatory medication in the preceding month; 3. chronic periodontitis with at least two pairs (clinically matched) displaced single-rooted teeth (each pair of teeth is in the same arch but in two contralateral hemi-arches respectively belonging to the same tooth typology) having at least one site probing depth of 5 mm or more, interproximal attachment loss of 3 mm or more, and radiographic signs of alveolar bone loss. 4. periodontal status confirmed by periodontal evaluation remains stable for at least 6 months after complete periodontal treatment. exclusion criteria: 1. smoking; 2. pregnancy; 3. under orthodontic treatment.

Keywords: malocclusion low-level laser therapy
canadian humira post marketing observational epidemiological study assessing effectiveness in psoriatic arthritis

Conditions: Psoriatic Arthritis

Summary: the current study will assess the real - life effectiveness of adalimumab in the management of articular and dermatological manifestations of moderate to severe psoriatic arthritis (psa).


Eligibility criteria:
inclusion criteria: * adult \>= 18 years old * has provided written informed consent allowing the use of their data for the study and providing permission for contact by the study personnel * active psoriatic arthritis (psa) with three (3) or more tender and swollen joints as well as active psoriatic skin lesions or confirmed history of psoriasis * inadequate response or non-tolerant to current disease-modifying antirheumatic drugs (dmard) based treatment for psa exclusion criteria: * currently participating in another prospective study including controlled clinical trials and observational studies * patient cannot or will not sign informed consent * stable disease with adequate tolerance and response to current treatment and no change in treatment is indicated * previous treatment with anti-tumor necrosis factor (anti-tnf) or other biologic agent

Keywords: assessing effectiveness in psoriatic arthritis
safety and efficacy of alx-0600 in subjects with active crohn's disease who completed protocol cl0600-008

Conditions: Crohn's Disease

Summary: the purpose of the study is to determine whether an investigational compound, alx-0600, is safe and effective in treating crohn's disease.

the study is sixteen weeks in duration and there are twelve weeks of once-daily injections into your abdomen or thigh. there are a total of five visits.

Eligibility criteria:
inclusion criteria: * subjects must have completed participation in the pilot active crohn's disease study. * subjects must continue to meet all inclusion criteria for pilot active crohn's disease study with the following exceptions: * cdai score greater than 220 * stool samples not required * c-reactive protein levels are not an exclusion criterion exclusion criteria: * subject must continue to meet all exclusion criteria for pilot active crohn's disease study with the following exceptions: * participation in a clinical study of an experimental drug or device within 30 days before signing consent.

Keywords: crohn disease crohn's disease
mohawk culture, behavior, toxicant exposure and health

Conditions: Thyroid Diseases; Cognition Disorders

Summary: this study will determine the pathways between mohawk cultural identification and specific behaviors related to pollutant exposure, and determine the effects of these factors and the pollutant exposure on physiologically and socially significant outcomes.

considerable concern now exists over possible effects on human physical and psychological development of endocrine disrupting environmental contaminants such as polychlorinated biphenyls (pcbs). native american communities are particularly at risk owing to subsistence systems and a cultural ethos involving greater contact with the physical environment. the proposed study follows-up 220 mohawk adolescents aged 17-21 years, who participated in a previous study when they were 10-16 years old. all adolescents are members of the mohawk nation at akwesasne which is located on the st. lawrence river and is adjacent to hazardous waste sites where pcbs have contaminated the local ecology. the investigation examines the interrelationship between mohawk cultural identity, traditional mohawk customs, behaviors related to toxicant exposure and current toxicant burden. serum level of pcbs will be assessed by congener specific analysis. the study will determine the relationship of congeners and their hydroxylated metabolites to thyroid function (levels of triiodothyronine, free triiodothyronine, thyroxine, free thyroxine, thyrotropin and anti-thyroid antibodies), and 2) psychosocial outcomes including school behavior and performance, hyperactivity, and adaptation to the community. data gathered for the past study will be employed to assess variation in metabolism of pcbs, as well as how earlier measures of cognition and hyperactivity relate to 17 year old psychosocial outcomes. variation in susceptibility to pcb effects will be determined by examining the effects of concurrent toxicant exposure (hexachlorobenzene, mirex, dichlorodiphenyldichloroethene, lead), diet, and indicators of pcb metabolism, on the focal measures of adult functioning. the proposed study will clarify the causal pathways between culturally identifying behavior, pcb exposure and body burden, thyroid functioning, cognitive functioning, social behavior and school functioning while identifying activities that are important to maintain cultural identify and unrelated to exposure.

Eligibility criteria:
participation in previous study of mohawk adolescent well-being is required for participation in this project.

Keywords: pcbs thyroid hyperactivity school performance mohawk tribe
confidential social network referrals for hiv testing

Conditions: HIV

Summary: despite worldwide efforts to promote hiv testing, rates of testing remain low. the purpose of this study is to evaluate the acceptability, efficacy, and cost-effectiveness of confidential sms-based social network referrals for hiv testing as a means of reaching high-risk individuals and prompting them to test for hiv. to accomplish this purpose, the study has 5 specific aims: aim 1 will conduct qualitative, formative work to identify desirable provider- and client-side characteristics of a confidential sms-based hiv testing referral system. aim 2 will adapt an existing mhealth system (mparis) to add consort functionality. aim 3 will pilot-test the consort system to collect preliminary data on the system's acceptability, performance, and potential efficacy. aim 4 will evaluate the acceptability and efficacy of consort in a randomized controlled trial. aim 5 will evaluate the incremental cost-effectiveness of consort vs. other referral options. if consort is shown to be acceptable, effective, and cost-effective, such mobile-phone supported, chain-referral methods could greatly improve the cost-effectiveness of hiv testing efforts.

no additional detail available

Eligibility criteria:
inclusion criteria: * at least 18 years old * live, work, or regularly receive care in moshi, tanzania * literate exclusion criteria: * under age 18 years * does not live, work, or regularly receive care in moshi, tanzania * illiterate