effect of peas in chili on blood glucose and appetite control

Conditions: Post-prandial Glycaemic Response; Satiety

Summary: this study is part of a group of studies whose overall goal is to accurately define the physiochemical and structural effects of pea varieties and relate these to blood glucose attenuation and appetite related sensations in healthy human volunteers.

a randomized, controlled, cross-over study designed to examine the ppgr and appetite related sensations to peas in chili will be conducted at the i.h. asper clinical research institute in winnipeg, manitoba. eligible participants who have provided consent will be asked to attend 4 clinic visits in a fasted state. participants will be given vegetarian chili containing peas at 2 visits and rice at 2 visits. at each visit participants will provide 7 venous blood samples via indwelling catheter, 7 capillary blood samples via finger poke, 2 urine samples, 5 questionnaires about their appetite and a questionnaire about the acceptability of the products. at the end of each visit, participants will eat pizza ad libitum, and the amount of pizza consumed will be measured to determine if the peas influenced the amount of calories consumed at lunch. participants will record their food/beverage intake for the rest of the day. each visit will last approximately 3h and be separated by 3-14 days.

Eligibility criteria:
inclusion criteria: 1. generally healthy male or female, between the age of 18-40 years; 2. body mass index (bmi) 18.5-30.0 kg/m2; 3. habitually consume breakfast, lunch and dinner in the morning, mid-day and evening, respectively. 4. willing to provide informed consent; 5. willing/able to comply with the requirements of the study. exclusion criteria: 1. pregnant or lactating; 2. medical history of diabetes mellitus, fasting blood glucose ≥6.1 mmol/l, hba1c ≥6.0%, or use of insulin or oral medication to control blood sugar; 3. medical history of cardiovascular disease; 4. systolic blood pressure \>140 mmhg or diastolic blood pressure \>90 mmhg; 5. fasting plasma total cholesterol \>7.8 mmol/l; 6. fasting plasma hdl \<0.9 mmol/l; 7. fasting plasma ldl \>5.0 mmol/l; 8. fasting plasma triglycerides \>2.3 mmol/l; 9. major surgery within the last 3 months; 10. medical history of inflammatory disease (ie. systemic lupus erythematosis, rheumatoid arthritis, psoriasis) or use of any corticosteroid medications within 3 months; 11. medical history of liver disease or liver dysfunction (defined as plasma ast or alt ≥1.5 times the upper limit of normal (uln)); 12. medical history of kidney disease or kidney dysfunction (defined as blood urea nitrogen and creatinine ≥ 1.8 times the uln)); 13. presence of a gastrointestinal disorder, daily use of any stomach acid-lowering medications or laxatives (including fibre supplements) within the past month or antibiotic use within the past 6 weeks; 14. active treatment for any type of cancer within 1 year prior to study start; 15. shift worker (a system of employment where an individual's normal hours of work are in part, outside the period of normal working day; 6am and 8pm); 16. smoking, use of tobacco or a nicotine replacement product (within the last 3 months); 17. allergies to peas; 18. aversion or unwillingness to eat study foods; 19. consuming \>4 servings of pulses per week; 20. use of any prescription or non-prescription drug, herbal or nutritional supplement known to affect glycaemia or appetite; 21. participation in another clinical trial, current or in the past 4 weeks; 22. unstable body weight (defined as \>5% change in 3 months) or actively participating in a weight loss program. 23. physical activity level \>1.8. 24. restraint score \>13 (factor 1) on the three factor eating questionnaire. 25. other medical, psychiatric, or behavioral factors that in the judgment of the principal investigator may interfere with study participation or the ability to follow the intervention protocol;

Keywords: blood sugar insulin appetite peas