Kornimate/medical-research-clean huggingface dataset:
immediate effects of tens and hvps on subacromial pain and shoulder movements

Conditions: Shoulder Pain Chronic

Summary: this study was performed to investigate the immediate effects of transcutaneous electrical nerve stimulation (tens) and high voltage pulsed stimulation (hvps) on resting pain and pain-free range of shoulder motion (pfrom) in patients with subacromial pain syndrome (saps).

transcutaneous electrical stimulation (tens) and high voltage pulsed current/stimulation (hvps) are both electrotherapeutic agents which can be used for pain relief in musculoskeletal conditions. standard tens devices usually deliver biphasic pulsed currents with a pulse duration between 50 μs and 1000 μs and pulse frequencies between 1 and 250 pps. hvps devices are tens-like devices which deliver direct current with twin monophasic spiked pulses of 10-500 v (500-ohm load) with a short pulse duration (microseconds). in both conventional tens technique and hvps for pain relief, the aim is to activate spinal gating mechanism by selectively stimulating large diameter aβ fibers. theoretically, high-frequency (\~10-250 pps), low-intensity (nonpainful) currents are most efficient in selectively activating aβ fibers, which is practically recognized by the user reporting 'strong but comfortable' nonpainful electrical paresthesia beneath the electrodes. there is no available evidence for the efficacy of tens in patients with subacromial pain. also, there has been little experimental work on the effects of hvps on pain relief in the literature, as well as no known study for its efficacy in saps.

Eligibility criteria:
inclusion criteria: * 18-65 years-old * pain with active shoulder movements * subacromial pain for 2 weeks-2 months * positive hawkins-kennedy and painful arc tests, infraspinatus weakness; in addition to these, for patients with partial rotator cuff tear, a negative drop-arm test * neer stage 1-2 exclusion criteria: * radiologically confirmed malignity * acromial/acromioclavicular arthritis * history of fracture or surgery in the affected shoulder-arm complex * clinically confirmed polyarthritis, rheumatoid arthritis, fibromyalgia, adhesive capsulitis or osteoarthritis of glenohumeral joint or subacromial region * cervical/thoracal spinal problem• neurological problems which may affect upper extremity movements or pain perception (stroke, peripheral neuropathy, brachial plexus lesion, etc.) * neer stage 3 and indication for surgery * usage of analgesic medication * obesity (body mass ≥30 kg/m2) * contraindications for tens or hvps * previous experience with electrophysical agents or physiotherapy * pregnancy

Keywords: subacromial pain joint range of motion electrotherapy physiotherapy impingement
artificial intelligence-assisted confocal laser endomicroscopy identification of intestinal metaplasia severity

Conditions: Intestinal Metaplasia; Artificial Intelligence; Confocal Laser Endomicroscopy

Summary: currently, the correa cascade is a widely accepted model of gastric carcinogenesis. intestinal metaplasia is a high risk factor for gastric cancer. according to sydney criteria, mild intestinal metaplasia was not associated with gastric cancer, while moderate to severe intestinal metaplasia was strongly associated with the development of gastric cancer. because intestinal metaplasia is distributed in various forms, the use of white light endoscopy lacks specificity, and the consistency with histopathological diagnosis is poor; pathological biopsy is still needed to make a diagnosis. at present, national guidelines suggest that olgim score should be used to evaluate the risk of gastric cancer, and patients with olgim grade iii/iv should be monitored by close gastroscopy. however, it requires at least four biopsies, which is clinically infeasible. confocal laser endomicroscopy allows real-time observation of living tissue, comparable to pathological findings.

gastric cancer is a common malignant tumor in digestive system diseases. currently, the correa cascade is a widely accepted model of gastric carcinogenesis. intestinal metaplasia is a high risk factor for gastric cancer and is considered a precancerous condition of intestinal type gastric cancer. according to sydney criteria, mild intestinal metaplasia was not associated with gastric cancer, while moderate to severe intestinal metaplasia was strongly associated with the development of gastric cancer. because intestinal metaplasia is distributed in various forms, the use of white light endoscopy lacks specificity, and the consistency with histopathological diagnosis is poor; pathological biopsy is still needed to make a diagnosis. at present, our national guidelines suggest that olgim score should be used to evaluate the risk of gastric cancer, and patients with olgim grade iii/iv should be monitored by close gastroscopy. however, it requires at least four biopsies, which is clinically infeasible. confocal laser endomicroscopy allows real-time observation of living tissue, comparable to pathological findings. therefore, we established artificial intelligence-assisted confocal laser endoscope technology to determine the high risk of gastric cancer in real time, instead of tissue biopsy.

Eligibility criteria:
inclusion criteria: * patients aged 18-80 years undergoing confocal gastroscopy exclusion criteria: * patients with severe cardiac, cerebral, pulmonary or renal dysfunction or psychiatric disorders who cannot participate in gastroscopy * patients with previous surgical procedures on the stomach * patients with contraindications to biopsy * patients who refuse to sign the informed consent form
deep neuromuscular blockade in strabismus surgery

Conditions: Strabismus

Summary: the purpose of this study is to determine if inducing a moderate or greater neuromuscular block (tof count 0-3) when performing a neuromuscular block in pediatric patients aged 3 to 18 years undergoing strabismus surgery under general anesthesia can reduce the incidence of the oculocardiac reflex.


Eligibility criteria:
inclusion criteria: * pediatric patients between the ages of 3 and 18 who are american society of anesthesiologists physical classification (asa) i, ii, or iii scheduled for strabismus surgery under general anesthesia. exclusion criteria: * patients with underlying cardiovascular disease * patients with preoperative electrocardiograms showing conduction disturbances * patients with neuromuscular disease * any other patient who, in the opinion of the investigator, is not a good candidate for the study.
move it, move id! promotion of physical activity in adolescents with intellectual disability

Conditions: Physical Activity; Health Promotion; Adolescents; Intellectual Disability

Summary: the aim of this study is to develop and implement an mhealth intervention focusing on the promotion of physical activity in adolescents with intellectual disability.

overweight and obesity are globally challenging health problems and major risk factors for a number of chronic diseases, including diabetes, cardiovascular diseases and cancer. sufficient physical activity (pa) is an important protective factor in the development of overweight and obesity. adolescents with intellectual disability (id) report lower levels of pa and higher rates of overweight and obesity in comparison to adolescents without id. there is a dire need to find ways to promote pa in adolescents with id for their present and future health. however, while pa promotion in adolescents is a welldeveloped science, there is only a handful of studies dedicated to adolescents with id. consequently developing and designing pa promotion interventions specifically tailored to the needs of youth with id is of the utmost importance. currently, however, there is a real knowledge gap in terms of fundamental research on crucial intervention mechanisms to promote pa in adolescents with id, as well as specific behaviour change theories adapted to this population. the aim of the current research project is to co-create and evaluate a theory-based mhealth intervention, which focuses on increasing pa for adolescents with id. the underlying framework within the intervention development is the behaviour change wheel, together with a co-creation approach which is a bottom-up approach in which the target group (adolescents with id in this case) is actively involved in the development of the intervention. the result of this approach is contextually appropriate intervention and intervention strategies.

Eligibility criteria:
inclusion criteria: * adolescents with mild id * dutch speaking * having a smartphone or tablet (or being able to use a test smartphone from the research group) * having enough motor skills to engage in pa exclusion criteria: * adolescents with moderate, severe or profound id
acne treatment with active oplon's patches

Conditions: Acne Vulgaris

Summary: the purpose of this study was to demonstrate the effect of short treatment with active oplon patches on acne.

patients with acne vulgaris were treated overnight with active patches. effect is observed at the end of the treatment and 24 hours later.

Eligibility criteria:
inclusion criteria: * acne vulgaris * over 18 years * signing informed consent exclusion criteria: * active treatment of acne * change in hormonal therapy * antibiotic treatment in a week prior to the experiment * sensitive skin * pregnancy
prone-position ct for diagnosing inguinal hernia

Conditions: Hernia, Inguinal

Summary: background: the aim of this study was to investigate the efficacy of prone-position computed tomography (ct) for detecting and classifying inguinal hernia relative to supine-position ct before laparoscopic inguinal hernia repair. materials and methods: sixty-eight patients who underwent laparoscopic transabdominal preperitoneal repair of inguinal hernia were enrolled in this prospective study. patients diagnosed with inguinal hernia by physical examination underwent abdominal ct in the supine and prone positions for preoperative assessment. the anatomy of the right and left inguinal regions was confirmed during the surgery and compared with the preoperative ct findings.


Eligibility criteria:
inclusion criteria: * inguinal hernia exclusion criteria: * emergency surgery for incarcerated hernia * femoral hernia * recurrent inguinal hernia after laparoscopic inguinal hernia repair
positive end-expiratory pressure-induced increase in central venous pressure as a predictor of fluid responsiveness in robot-assisted laparoscopic surgery

Conditions: Prostatic Neoplasm; Urinary Bladder Neoplasm

Summary: in urologic robotic surgery with steep trendelenburg position, maintenance of cardiac preload and cardiac output is important for clinical prognosis. previous studies reported the positive end-expiratory pressure (peep)-induced increase in central venous pressure (cvp) could be a accurate predictor of fluid responsiveness in cardiac surgical patients. the authors attempt to evaluate the predictability of peep-induced increase in cvp as well as stroke volume variation in urologic robotic surgery with steep trendelenburg position.

in urologic robotic surgery with steep trendelenburg position, maintenance of cardiac preload and cardiac output is important for clinical prognosis. as a preload index, the predictability of central venous pressure, pulse pressure variation and stroke volume variations may be impaired due to the impaired hemodynamics that result from the effect of increased abdominal pressure and decreased venous return. previous studies reported the positive end-expiratory pressure (peep)-induced increase in central venous pressure (cvp) could be a accurate predictor of fluid responsiveness in cardiac surgical patients. therefore, the authors attempt to evaluate the predictability of peep-induced increase in cvp as well as stroke volume variation in urologic robotic surgery with steep trendelenburg position.

Eligibility criteria:
inclusion criteria: * adult patient undergoing robot-assisted laparoscopic radical prostatectomy or cystectomy. * american society of anesthesiologist physical status classification of 1, 2 or 3. exclusion criteria: * medical history of arrhythmia or new-onset arrhythmia after anesthesia induction. * valvular or ischemic heart disease or left ventricular ejection fraction less than 40%. * any significant pulmonary disease or history of chronic obstructive pulmonary disease * end-stage renal disease or preoperative creatinine \> 1.4 mg/dl

Keywords: fluid responsiveness central venous pressure positive end-expiratory pressure robot surgery
simple verbal intervention for adequately collecting sputum

Conditions: Suspicious for Pulmonary Tuberculosis

Summary: simple verbal intervention with figure of lung and upper respiratory tract will be helpful to adequately collecting sputum. and in the acceptable specimen based on gram stain, positivity for afb stain and culture rate will be higher.

suspicious patients for pulmonary tuberculosis are randomized to control or education group. patients in education group will be educated with the brochure that contains figure of lung/upper respiratory tract and methods of collecting sputum.

Eligibility criteria:
inclusion criteria: * age \> 18 years * 2009.7\~2010.7 patients with suspicious pulmonary tuberculosis who visited boramae hospital exclusion criteria: * on medication for tuberculosis * patients who medicated with fluoroquinolone within 1month * patients without consciousness or patients who cannot expectorate sputum * hemoptysis over 50cc per day * patients who don't consent on the study

Keywords: acceptable sputum afb culture pulmonary tuberculosis
malignant pediatric soft tissue & bone tumors of the extremities: a retrospective study

Conditions: Soft Tissue Neoplasms; Bone Neoplasms

Summary: the aim of this study is to identify demographic \& disease characteristics in pediatric oncology patients diagnosed with soft tissue \& bone tumors involving the extremities \& treatment outcomes in these patients.

background: sarcomas are a heterogeneous group of rare tumors that arise predominantly from the embryonic mesoderm. the various sarcomas include bone sarcomas (osteosarcomas and chondrosarcomas), ewing's sarcomas, peripheral primitive neuroectodermal tumors, and soft tissue sarcomas. soft tissue sarcomas account for approximately 1% of adult malignancies and 7% to 15% of pediatric malignancies. rhabdomyosarcoma is the most common soft tissue sarcoma of childhood. there is some confusion within segments of the medical community as to the precise meaning of "soft tissue." the soft tissue of the human body includes all extraskeletal tissue that is neither epithelial, hematopoietic (marrow derived blood elements), nor parenchymal (constituent of a visceral organ). the nervous system is divided such that neither the glial nor the central neuronal elements are considered to be soft tissue, though by convention the peripheral nervous system is. in sum, the soft tissues consist of adipose tissue, fibrous tissue, musculature, vascular structures, and peripheral nerves. about 50% to 60% of sarcomas occur in the extremities, and although they are rare, they are responsible for more deaths than testicular cancer, hodgkin's disease, and thyroid cancer combined. patients \& methods: from january 2000 till december 2015, retrieval \& analysis of the medical records of pediatric patients with soft tissue \& bone tumors involving the extremities will be made at the pediatric oncology department, south egypt cancer institute which represents the largest referral center in upper egypt. these data will be categorized according to demographic characteristics, clinico-pathologic features, treatment modalities received, and outcomes of treatments in these patients.

Eligibility criteria:
inclusion criteria: * patients whose age less than 19 years. * patients diagnosed with bone \& soft tissue neoplasms involving the extremities. exclusion criteria: * patients whose age more than 19 years. * patients diagnosed with bone \& soft tissue neoplasms not involving the extremities.

Keywords: childhood cancer soft tissue tumors bone tumors extremity tumor pediatric oncology
pristinamycin in the treatment of mssa bone and joint infection

Conditions: Methicillin Susceptible Staphylococcus Aureus (MSSA) Infection; Bone and Joint Infection

Summary: staphylococcus aureus represents the leading pathogen implicated in bone and joint infection (bji), usually requiring prolonged combination antimicrobial therapy, which may be particularly challenging in the case of mdr bacteria and/or for patients with multiple drug intolerance. in the absence of new well-tolerated oral antistaphylococcal drugs, older antibiotics must be considered, such as the pristinamycin. however, pristinamycin is not currently licensed for treatment of staphylococcal bji and lack of clinical data prevents it from being considered as a reliable alternative therapeutic option in current guidelines. the aim of this study is to evaluate pristinamycin (efficacy and tolerance) in the treatment of mssa bone and joint infection (bji).


Eligibility criteria:
* inclusion criteria: * all patients receiving pristinamycin as a part of treatment for an mssa bji and followed up between 2001 and 2011 in the infectious diseases department of hospices civils de lyon (hcl) * exclusion criteria: * patients with bji related to diabetic foot or decubitus ulcer

Keywords: pristinamycin staphylococcus aureus bone and joint infection
creative arts therapy (cat) in the center for cancer and blood disorders

Conditions: Cancer

Summary: the purpose of the study is to evaluate the effectiveness of creative arts therapy (cat) on pediatric patients undergoing chemotherapy in the infusion center at children's hospital colorado center for cancer and blood disorders. findings from a previous pilot study support the hypothesis that cat may improve quality of life (qol), resiliency, physical posture, and emotional response to pain of pediatric oncology patients undergoing chemotherapy.

a repeated measures design will be used with each patient serving as his/her own control. the subjects and/or parents will be tested with all instruments before the intervention, and approximately every 30 days for no less than 3 months and a maximum participation of 6 months. treatment time points will be at least 30 days apart. because some subjects are not scheduled to come into the clinic every 30 days for soc appointments, they are unable to complete 3 sessions of cat in a 3 month time period. for those subjects who are scheduled to come into clinic every 1-2 months for soc appointments, study participation may take up to 6 months. this 6 month time period would allow for the completion of 4 different time points of cat. the testing will take place in an exam room after vital signs have been completed upon intake to the clinic. the trained research assistant, trained rn, or pi will administer the questionnaires. the pedsql includes a subject report (ages 5 and over) and a parent report. the resilience scale is a self-report and will be used for ages 12 and over. the faces scale will use parent report for ages less than 5 and self-report for ages 5 and over. in order to confirm consistency, the posture measure will be completed by the pi (nurse practitioner) or registered nurse on the study after training with the manual included with the inclinometer tool.

Eligibility criteria:
inclusion criteria: * center for cancer and blood disorders (ccbd) patient with oncology or neuro-oncology diagnosis * no more than 2 previous sessions of cat as an outpatient in the ccbd * english speaking * receiving outpatient chemotherapy, biotherapy, or transfusions in the infusion center approximately weekly for at least 3 months. * ages 3 to 18 years exclusion criteria: * hematology or other patients in the infusion center * patients who have previously received more than 2 sessions of cat in the infusion center * non-english speaking patients
the effects of fresh mango consumption on cardiometabolic outcomes in free-living individuals with prediabetes

Conditions: Hyperglycemia; Dyslipidemias; Insulin Resistance; Inflammation; Oxidative Stress

Summary: the goal of this clinical trial is to test the effect of 12 weeks of 1.5 cups per day of fresh mango on glucose control, insulin resistance, lipids, inflammation, oxidation and body composition in individuals with prediabetes. the main questions it aims to answer are: * what is the effect of 1.5 cups per day of fresh mango over 12 weeks on indicators of glycemic control including fasting glucose and hgba1c? * what is the effect of 1.5 cups per day of fresh mango over 12 weeks on fasting blood insulin and insulin resistance (homa-ir)? * what is the effect of 1.5 cups per day of fresh mango over 12 weeks on lipids including ldl-cholesterol, total cholesterol, hdl-cholesterol and triglycerides? * what is the effect of 1.5 cups per day of fresh mango over 12 weeks on oxidative stress including oxidized ldl-cholesterol and 8-iso-pgf2-alpha? * what is the effect of 1.5 cups per day of fresh mango over 12 weeks on markers of inflammation including c-reactive protein, e-selectin, icam, vcam, tnf-alpha and il-beta? * what is the effect of 1.5 cups per day of fresh mango over 12 weeks on percent body fat, fat mass, and lean mass? participants will be asked to: * consume 1.5 cups of mango per day for 12 weeks, take a 4 to 8 week break, and then avoid consuming mangos for 12 weeks * attend a prerandomization clinic prior to study * attend three (3) clinics where blood will be drawn during weeks 0, and 12 of the first phase and last week of the second phase of the study * attend eight (8) clinics where anthropometric measurements (height, weight, body composition) will be conducted and interaction with study clinicians will occur during weeks 0, 4, 8, 12 of each phase of the study * complete questionnaires and surveys in person and remotely, including six (6) 24-hour dietary recalls. researchers will compare the 12 weeks participants consume mango to the 12 weeks the participants are not consuming mango to see if there are differences in glycemic indicators, insulin resistance, lipids, inflammation, oxidation and body composition between the two time periods.


Eligibility criteria:
inclusion criteria: * hgba1c of 5.7 to 6.4% indicative of prediabetes * abdominal obesity as defined as a waist circumference \>102 cm for men or \>88 cm for women exclusion criteria: * self-reported chronic disease history (diabetes, heart disease, cancer, kidney disease, inflammatory bowel disease, etc.) * pacemaker * mango allergies * latex allergies (cross-reactive with mango) * smoking, use of tobacco, or high alcohol intake (\>2 drinks/day for men or \>1 drink per day for women) * recent significant weight loss (\>5% within 6 months of study enrollment) * bmi \>35 kg/m\^2 * pregnancy or lactation * use of medication and/or supplements affecting glycemic indicators or lipids * habitual mango intake of \>3 servings per week and/or habitual fruit intake of \>2 servings per day * not able to read and/or communicate in english
treatment of binge eating disorder

Conditions: Binge Eating Disorder

Summary: this is a study examining the use of different degrees of therapist involvement in the treatment of binge eating disorder. the study will examine both which approaches work best for decreasing symptoms and which are most cost-effective.


Eligibility criteria:
* binge eating disorder * age 18-65, male or female * not currently receiving psychotherapy * not currently in formal weight loss treatment * no current unstable medical problems * no history of bipolar illness or schizophrenia * overweight or obese (body mass index 25-45)