Kornimate/medical-research-clean huggingface dataset:
pediatric atopic dermatitis (ad) internet survey

Conditions: Atopic Dermatitis

Summary: the purpose of this study is to evaluate whether participation in an internet-based intervention helps improve atopic dermatitis treatment outcomes.


Eligibility criteria:
inclusion criteria: * any child age 2 to 8 with a diagnosis of atopic dermatitis confirmed by a dermatologist, together with the child's parent/guardian. written consent must be given by parent/guardian. exclusion criteria: * child is less than 2 or greater than 8 years of age. * known allergy or sensitivity to topical triamcinolone in the child. * inability to complete all study-related visits, or inability to complete the internet survey due to inadequate internet access. * introduction of any other prescription medication, topical or systemic, for atopic dermatitis while participating in the study. subjects who are on systemic anti-inflammatory treatments for atopic dermatitis must be on a stable dose for at least 3 months prior to enrollment.
multiple-dose study apixaban in pediatric subjects with an indwelling central venous catheter

Conditions: Venous Thromboembolism

Summary: cv185-079 is a multiple dose apixaban pharmacokinetics/pharmacodynamics (pk/pd) study in pediatric subjects. the objective of this study is primarily to study the pk/pd of apixaban in pediatric subjects with a central venous catheter.


Eligibility criteria:
inclusion criteria: * subjects with chronic stable disease with any type of functioning cvc in the upper or lower venous system (e.g., jugular, subclavian; femoral vein) that is anticipated to remain in the subject for the treatment portion of the study. * \> 12 to \<18 years of age exclusion criteria: * current or recent (within 3 months of study drug administration) gastrointestinal disease or gastrointestinal surgery that, in the opinion of the investigator and the bms medical monitor, could impact the absorption of the study drug * active bleeding or high risk of bleeding
management of placenta accreta spectrum

Conditions: Placenta Previa; Placenta Accreta

Summary: placenta accreta spectrum is group of disorders which have a depate about the best way of management. this is a descriptive study about the best techniques to reduce morbidity and mortalities related to it.

placenta accreta spectrum is group of disorders which have a depate about the best way of management. this is a descriptive study about the best techniques to reduce morbidity and mortalities related to it. 1. surgical management of placenta accreta 2. short term follow up to the outcomes 3. long term follow up

Eligibility criteria:
inclusion criteria: * all placenta accreta e high possibility of placenta accrete * consent * easy follow up visits exclusion criteria: * bleeding tendency * associated medical disorder hypertension, diabetes, preeclapsia..

Keywords: placenta accreta praevia hyterectomy pph
is there an association between quadriceps strength and different markers of fragility in patients with cirrhosis?

Conditions: Cirrhosis

Summary: physical frailty and malnutrition are important factors in morbidity and mortality in patients with cirrhosis. no study has assessed the validity of liver frailty index (lfi) against reference measures such as maximal lower limb strength. main objective: to assess the association between lfi score and isometric maximal lower limb strength (quadriceps) in patients with cirrhosis.


Eligibility criteria:
inclusion criteria: subject : * with a diagnosis of liver cirrhosis (regardless of cirrhosis stage and etiology) * under the care of a physician practising in the university hospital estaing in clermont-ferrand * affiliated to the french social security system exclusion criteria: subject: * with hepatocellular carcinoma * with hiv infection * with hepatic encephalopathy grade ≥ 2 * with cognitive dysfunction * with contraindication for physical activity * with knee pain/knee disorders * pregnant or breastfeeding * under protective supervision (guardianship, curatorship, protection of the court)

Keywords: frailty markers quadriceps strength
effectiveness of oral lactulose versus lactulose enema in hepatic encephalopathy

Conditions: Hepatic Encephalopathy; Chronic Liver Disease

Summary: patients with chronic liver disease due to hepatitis b or c viruses, non-alcoholic fatty liver disease, autoimmune hepatitis, wilson disease, cryptogenic hepatitis etc are prone to develop complications. hepatic encephalopathy is one of such complications. it is graded into four types depending on severity of clinical features, which range through altered sleep pattern to coma. the current study aims to compare the effectiveness of lactulose enema with oral lactulose in time to recovery from higher grade of encephalopathy to lower grade of encephalopathy.

hepatic encephalopathy (he) is defined as neuropsychiatric disorder due to liver failure. it is characterized by mild cognitive impairment, stupor and coma. the most common reasons for pathogenesis include the role of neurotoxins, impaired neurotransmission due to metabolic changes in liver failure, changes in brain energy metabolism, systemic inflammatory response and alterations of the blood brain barrier. neurotoxin ammonia is related to precipitating he, for which the gastrointestinal tract is the primary source. colonic bacteria catabolise the nitrogenous sources into ammonia. lactulose is the initial treatment for he. it produces diarrhea by osmosis and reduces ph of colonic contents, which leads to reduced absorption of ammonia by converting it to ammonium ion (nh4). understandingly, it does not cure the underlying liver disease however, it does prevent deterioration of the mental status in he. initial oral dose of lactulose is 30 ml once a day or twice daily. for retention enema the dose is 300 ml lactulose plus 700 ml water, administered every 4 hours. it can be increased as tolerated. at least, 2-4 loose stools per day should be passed by the patient. lactulose is also effective as primary prophylaxis against the development of he. constipation is one very common precipitating factor for hepatic encephalopathy which is routinely managed with oral lactulose or kleen enema (21.4g (18.1% w/v) sodium dihydrogen phosphate dihydrate and 9.4g (8.0% w/v) disodium phosphate dodecahydrate). lactulose enema is also given to patients in hepatic encephalopathy either alone or in combination with oral lactulose. however it is not clear whether there is any difference in the efficacy of oral or enema lactulose in patients with hepatic encephalopathy in terms of improvement of encephalopathy grade and time to improvement. this study aims to determine the efficacy of oral versus enema lactulose in the achievement of these goals.

Eligibility criteria:
inclusion criteria: * male and female cirrhotic patients in grades 3 or 4 of hepatic encephalopathy * patient with constipation as the precipitating factor will be included in the study exclusion criteria: * patients with dehydration * electrolyte abnormalities * spontaneous bacterial peritonitis (sbp), * fever * using sedative / hypnotic medications as predisposing factors for hepatic encephalopathy
stress free ucr: the impact of 8 weeks of headspace on stress in a heterogeneous university employee cohort

Conditions: Stress, Psychological

Summary: the aim of this study is to test the effects of a digital meditation intervention in a sample of high stress ucr employees. we will randomize ucr employees to 8-weeks of either a digital mindfulness intervention (using the commercially available application headspace) or a waitlist control condition. participants assigned to the intervention group will be asked to download and use the headspace mobile application for 10 minutes per day for 8 weeks. they will be asked to fill out short (no longer than 30 minutes long) questionnaires at baseline, week 4, week 8 (post intervention), and a 4-month follow up period. participants who are randomized to the digital meditation intervention will also take part in a 1-year follow up. all activities will take place online (via computer or smartphone), and on the participants' own time.

high levels of psychosocial work-related stress have major implications for both the employee and the employer. epidemiological studies consistently demonstrate associations between high work stress and worse self-reported mental and physical health, including depression, anxiety, cardiovascular disease, and type 2 diabetes. job strain, a combination of high demands and low control, is a common model used to define psychosocial stress at work. job strain is associated with worse mental and physical health, including anxiety and depressive disorders and increased blood pressure. past studies show the value in mindfulness applications. for example, participants who completed 25 or more meditation sessions over 8 weeks also had significantly lower self-measured systolic blood pressure over the course of one day compared to the control condition participants at the follow-up time point. this trial suggests that almost daily brief mindfulness meditations delivered via smartphone can improve outcomes related to workplace stress and well-being, with potentially lasting effects. in this study, investigators hope to determine if a stress-reduction mindfulness application is more effective than a waitlist control condition in employees who are experiencing mild to moderate levels of stress in various health and productivity-related outcomes.

Eligibility criteria:
inclusion criteria: * have access to a smartphone or computer every day * are fluent in english * are a ucr employee * have moderate to high levels of stress * consent: demonstrates understanding of the study and willingness to participate as evidenced by voluntary informed consent and has received a signed and dated copy of the informed consent * are at least 18 years of age exclusion criteria: * experienced meditator or have participated in a formal meditation practice in the last 6 months (defined as 3-4 times or more per week)

Keywords: stress, health, meditation, mindfulness, employees, job strain, burnout, work, help, mood, affect
comparison of standing versus supine 3d cone beam computed tomography in patient with obstructive sleep apnea

Conditions: OSA; Sleep Apnea

Summary: the anatomical changes of the upper airway in a standing vs pseudo-supine position using carestream orthodontic imaging (volumetric) and carestream orthodontic imaging module (ap measurements) of the patient's airway respectively, have been taken and the obtained results compared. in order to simulate the supine position, patients are placed in a supine position (180 degrees) in a dental exam chair, and asked to relax their lower jaw, allowing it to drop back, simulating their jaw falling back while sleeping. that bite is then captured with a correct plus™ impression material superfast. once the bite material hardens, it locks the bite in place. the patient then stands upright, and cbct is taken standing while the jaw placement is still pseudo sleep-supine, supported by the bite material.


Eligibility criteria:
inclusion criteria: * participant must be a patient of dr. maryam bakhtiyari's orthodontic practice * participant must have a diagnosis of obstructive sleep apnea * participant must have an invitation to join research study from dr. bakhtiyari exclusion criteria: * participant cannot have a history of serious dental trauma

Keywords: tomography cbct cone-beam computerized tomography obstructive sleep apnea airway volume anterior-posterior measurement
post cond no reflow

Conditions: Myocardial Reperfusion Injury

Summary: after having shown that postconditioning allowed a significant 36% reduction of infarct size as assessed by blood levels of myocardial enzymes in acute myocardial patients, the investigators objective is to assess the effect of postconditioning in acute myocardial infarction (ami) patients on microvascular obstruction lesions defined by cardiac mri images.


Eligibility criteria:
inclusion criteria: * patients \> 18 years old, * male or female, * presenting first myocardial infarction, with the beginning of pains \< 12 hours, * requiring a revascularisation by primary angioplasty or " rescue " (after failure of thrombolysis) on iva or rca (not ca). * artery guilty with timi flow = 0 exclusion criteria: * cardiac arrest before the angioplasty, * cardiogenic shock * occlusion of the artery circumflex responsible for the infarction * magnetic resonance imaging: contre indication

Keywords: myocardial infarction postconditioning microvascular obstruction no reflow mri
awareness, care & treatment in obesity management - an observation in asia pacific

Conditions: Obesity

Summary: action apac is a cross-sectional, observational, descriptive, and exploratory survey-based study without collection of laboratory data. the study is not related to any specific treatment options or pharmaceutical product. collection of data will be performed via quantitative online survey by a third-party vendor through existing databases/panels in apac region. the goal of this study is to provide insights to drive awareness around the needs of people living with obesity (plwo) and health care professionals (hcps) involved in obesity treatment and management.


Eligibility criteria:
inclusion criteria: people living with obesity 1. informed consent obtained before any study-related activities (study-related activities are any procedure related to recording of data according to the protocol). 2. male or female, aged above or equal to 18 years at the time of signing informed consent 3. lives in one of the target countries 4. current bmi of at least 25 kg/m\^2 for all countries (except singapore which has current bmi 27 kg/m\^2) based on self-reported height and weight health care professionals 1. informed consent before any study related activities (study-related activities are any procedure related to recording/collection of data according to protocol) 2. male or female, aged greater than or equal to 18 years at the time of signing informed consent. 3. physician 4. primary care providers (pcps) whose specialty is family practice, general practice, internal medicine 5. non-pcp specialties whose specialty is endocrinologist, cardiologist, gastroenterologist, obstetrics/gynaecologist, bariatrics/obesity medicine, nutrition specialist (physician) orthopaedist, aesthetics medicine 6. specialty is not surgeon (including bariatric or plastic surgeon) 7. practices in the target countries 8. in clinical practice for at least 2 years 9. spends at least 50% time in direct patient care 10. has seen at least 100 patients in past month 11. has seen at least 10 patients in past month who have obesity defined as: a patient with a bmi greater than or equal to 25 kg/m\^2 for all countries (except singapore which has current greater than or equal to bmi 27 kg/m\^2) with or without comorbidities. exclusion criteria: people living with obesity 1. previous participation in this study. participation is defined as having given online consent in this study 2. currently pregnant 3. participates in intense fitness or body building programs 4. has had significant, unintentional weight loss (due to major injury, illness, etc) in the past 6 months 5. mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation health care providers 1. previous participation in this study. participation is defined as having given informed consent in this study. 2. unwillingness, inability, or language barriers precluding adequate understanding or cooperation
adapt a direct aspiration, first pass technique for the endovascular treatment of stroke

Conditions: Stroke Technique

Summary: in collaboration with the neurointerventional programs at state university of new york buffalo, state university of new york stonybrook, swedish medical center, erlanger health system, vanderbilt university, and west virginia university school of medicine, the investigators aim to prospectively collect experiences where direct aspiration as a first pass technique is used for thrombectomy procedures. the investigators also want to compare specific characteristics from these cases to other stroke cases where traditional thrombectomy devices were used.

traditionally, at a physician's discretion, first pass attempts at thrombectomy procedures are performed with any number of fda cleared catheters, guide wires, and devices designed for efficient removal of clot within an intracranial vessel. among institutions involved in this case study, the latest devices are readily available and fully support standard treatment paradigms. however, several cases, recently completed, using only large bore catheter and aspiration have anecdotally demonstrated a superior ability to remove clot from vessels, restoring blood flow to the affected vessel and brain tissue. in these limited number of cases, full restoration of blood flow has been achieved. while this combination of approved devices is minimalistic, the efficiency of the procedure, rapid technical success, and relative simplicity of the approach is unique and should be thoroughly reviewed and possibly prepared for publication.

Eligibility criteria:
inclusion criteria: * all patients who were treated with direct aspiration as a first pass choice or treated with a stent retriever will be included. exclusion criteria: * patients not treated with either direct aspiration as a first pass, or stent retriever will not be included.
safety and pharmacokinetic study of pf-06651600 in healthy volunteers

Conditions: Healthy

Summary: this study is a first in human study of pf-06651600. pf-06651600 is being developed for treatment of inflammatory bowel disease. this study will test single and multiple doses of pf-06651600. the goal of the study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of pf-06651600 in healthy volunteers.


Eligibility criteria:
inclusion criteria: * healthy male/female subjects between 18 and 55 years old, inclusive. females must be of non-child bearing potential. * bmi of 17.5 to 30.5 kg/m2; and a total body weight \>50 kg (110 lbs). * evidence of personally signed and dated informed consent document. * willing and able to comply with scheduled visits, treatment plan, lab tests and other study procedures. * subjects must avoid high intensity uv light exposure (eg, active sunbathing, tanning beds/booths or sunlamps) from the first dose of study drug and for the duration of the study. exclusion criteria: * evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gi, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease. * use of tobacco/nicotine containing products in excess of 5 cigarettes/day. * history of regular alcohol consumption exceeding 14 drinks/week for females or 21 drinks/week for males. * screening blood pressure \>140/90 mm hg. * screening laboratory abnormalities as defined by the protocol. * unwilling or unable to comply with the lifestyle guidelines as defined by the protocol.

Keywords: inflammatory bowel disease
cough in eastern and central finland

Conditions: Chronic Cough

Summary: comparison of citric acid and mannitol cough provocation tests among subjects with chronic cough and healthy volunteers.

35 subjects with chronic cough plus 25 subjects without any cough will be asked to participate. the study consists of two visits in the outpatient clinic of kuopio university hospital, department of respiratory medicine, 2 - 7 days apart. they will fill in the leicester cough questionnaire and undergo two different cough provocation tests, in random order: mannitol test and citric acid test. if a chest x-ray has not been taken within 6 months, it will be taken.

Eligibility criteria:
inclusion criteria, chronic cough patients: (both criteria must be fulfilled) * presence of current chronic cough (\> 8 weeks) * leicester cough questionnaire total score \< 17 inclusion criteria, healthy volunteers * absence of any form of cough exclusion criteria: * age \< 18 years * any disability which would challenge the subject's ability to understand the purpose and methods of the study * pregnancy * breastfeeding * current smoking or ex smoking more than 10 pack years * any thoracic x-ray finding indicating urgent mediacal interventions

Keywords: cough cough provocation test mannitol citric acid
visibility of lesion characteristics with phase contrast mammography

Conditions: Breast Cancer

Summary: to determine if diagnostic phase contrast mammography (pcm) will provide improved image detail in assessing lesion characteristics when compared to diagnostic x-ray mammography (xm).

the ability to detect lesions in mammography before they can be felt is the benefit of using this imaging modality for screening of breast cancer. screening mammography has been proven to decrease mortality from breast cancer. radiologists identify abnormal breast tissue in the form of microcalcifications, masses, architectural distortion, and asymmetric density by careful assessment of the characteristics of these types of lesions using the breast imaging reporting and diagnostic system (birads). birads was developed to provide standardization of reporting of mammographic exams. in screening mammography, while it is possible to detect lesions, often more detailed diagnostic imaging is necessary to improve the visibility of margins and edges of lesions through magnification and compression views of the lesion of interest due to spatial resolution limitations which causes geometric blurring of edges in x-ray mammography. if the ability to clearly see margins and edges of lesions is possible at screening mammography, this would potentially decrease the overall radiation exposure currently needed to allow radiologists to be confident of their characterizations for the majority of patients using x-ray mammography. digital mammography was developed to improve the visibility of lesions primarily in dense breasts. the reasoning was that the improved contrast range would allow for wider range of gray level differentiation but with digital mammography comes a spatial resolution limitation that blurred edges of lesions. phase contrast mammography (pcm) was developed to improve digital mammography by providing improvement in sharpness of edges utilizing the x-ray properties of refraction. comparison: phase contrast mammography to x-ray mammography for lesion visibility of diagnostic population

Eligibility criteria:
inclusion criteria: * at least 40 years old * female * scheduled for diagnostic work-up including compression/magnification views of screening detected breast lesion exclusion criteria: * \< age 40 * male * no screening detected findings * breast implants * any women who is pregnant or has reason to believe she is pregnant or lactating * women with breasts larger than the 24 x 30 cm receptor

Keywords: diagnostic mammography breast imaging phase contrast mammography x-ray mammography