Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of cefditoren pivoxil versus ciprofloxacin in acute uncomplicated cystitis

Conditions: Urinary Tract Infections

Summary: the main objective of the study is to comparatively assess the efficacy and tolerability of the drugs under study in the treatment of acute uncomplicated cystitis.

urinary tract infections (uti) are one of the most frequent reasons of surgery visits in primary care. more than 95 percent of utis are monomicrobial, although the microorganisms implied are varied, and the range of effective drugs could be extensive. the species most frequently isolated is escherichia coli, with prevalence ranking between 85 and 90 percent of documented cases. e. coli has developed resistance to different antibiotics. cefditoren is situated as a good candidate for the treatment of uncomplicated utis due to its spectrum of activity against e. coli. the study has been designed in accordance with the guidelines and recommendations in force to assess the efficacy of cefditoren pivoxil against ciprofloxacin, a drug which despite the increasing rate of resistance in some countries, continues to be a drug of choice for the treatment of uncomplicated utis.

Eligibility criteria:
inclusion criteria: * non-pregnant adult females (\>= 18) * clinical signs and symptoms of uncomplicated acute cystitis (dysuria, urgency, frequency, suprapubic pain) with symptoms starting \<=72 hours prior the study entry * positive pre-treatment clean-catch midstream urine culture (\>= 103 cfu/ml) and pyuria (10 leukocytes/mm3 or more than 5 leukocytes/field 40x magnification) within the 48 hours prior to inclusion in the study * in vitro susceptibility testing of the isolated uropathogen to the drugs under study * written informed consent exclusion criteria: * males * woman who are pregnant, nursing or not using a medically accepted, effective method of birth control * three or more episodes of uncomplicated acute infections of the urinary tract during the past 12 months * symptoms starting \>4 days prior to admission * body temperature \>= 38.3ºc, back pain, chills or other manifestations suggestive of upper urinary infection * evidence of structural or functional alterations of the urinary tract, such as calculi, stenosis, primary renal disease (eg. polycystic renal disease) or neurogenic bladder * underlying disease predisposing to complicated urinary tract infections such as diabetes mellitus, immunosuppression, leucopenia, heart insufficiency, liver impairment and neoplastic processes

Keywords: cystitis
effect of polymorphisms in the il-1 gene complex on the development of chronic hepatitis and hepatocellular carcinoma

Conditions: Hepatitis B; Carcinoma, Hepatocellular; Polymorphism, Genetic

Summary: the purpose of this study is to determine the effect of polymorphisms in the il-1 gene complex on the development of chronic hepatitis and hepatocellular carcinoma.

we analyzed single-nucleotide polymorphisms in the genes for interleukin-1a, interleukin-1b, interleukin-1-receptor antagonist, interleukin-1-receptor type i, and interleukin-1-receptor type ii in 400 normal control and patients (chronic hepatitis and hepatocellular carcinoma). genotypes were tested for an association with development of chronic hepatitis and hepatocellular carcinoma by multivariable analysis. a second cohort of 1200 normal control and patients (chronic hepatitis and hepatocellular carcinoma) was independently analyzed for the genotype associations identified in the first cohort.

Eligibility criteria:
inclusion criteria: * normal controls * cases of chronic hepatitis and hepatocellular carcinoma exclusion criteria: * pregnant women

Keywords: hepatitis b carcinoma, hepatocellular polymorphism, genetic
is y-balance test predictive of concussion

Conditions: Concussion, Brain; Concussion; Eye

Summary: the y balance test for the lower quarter (ybt-lq) is a movement screen used to assess an athlete's risk for injury. the ybt-lq is a dynamic balance test where the participant stands on a single leg and with the opposite lower extremity reaches are far in the anterior direction as they can, and this value is measured. the process is repeated in the posterior medial, and the posterior lateral directions. the final values are controlled for leg length of the participants. the ybt-lq has been shown to be predictive of lower extremity injury in high school basketball players, but it is typically used as part of a battery of tests to determine the athlete's overall injury risk, but more questions remain to be answered. the research question: is the ybt-lq predictive of concussion in high school athletes? what are the norms for ybt-lq in high school athletes? does history of concussion effect ybt-lq? is the ybt-lq with visual perturbations predictive of concussions? is the ybt-lq with visual perturbations predictive of lower extremity injury? what is the impact of visual perturbations on y-balance and its injury prevention capability? the target student participants will be 9th through 12th grade students; however, 6th to 8th grade students will be allowed to participate depending on the school or organization request. informed consent will be obtained reiterating that participation is voluntary. testing utilizing the ybt-lq will occur, and sport of participation, age, height, weight, dorsiflexion, and leg length will be obtained. follow up will be made via the athletic trainers and school personnel to indicate the effected athletes. once the post-test follow up is complete athletes will be able to see their pre-test scores, and any questions will be answered at that time. this will be a longitudinal study where testing will take place at least two times per year, preferably three times per year over 4 years.


Eligibility criteria:
inclusion criteria: * participates in sport either school sanctioned or club exclusion criteria: * history of seizure
measure of acceptance of chronic visible skin conditions

Conditions: Acceptance of Visible Chronic Dermatological Disease; Disease Acceptance; Psychological Well-Being; Social Segregation

Summary: the objective of this protocol is to validate 4 scales for evaluating the acceptance of visible chronic dermatological diseases (port wine stains, alopecia areata, vitiligo, hyperpigmentation...) with a large number of patients (children, adolescents, adults) and their parents (depending on the composition of the family cluster), in a multicentric manner (for territorial representativeness).

the objective of this protocol is to validate 4 scales for evaluating the acceptance of visible chronic dermatological diseases (port wine stains, alopecia areata, vitiligo, hyperpigmentation...) with a large number of patients (children, adolescents, adults) and their parents (depending on the composition of the family cluster), in a multicentric manner (for territorial representativeness). the investigator will screen the patients and give them a link to complete the questionnaire (according to the age), that includes a pre-scale of acceptation of 50-55 items.

Eligibility criteria:
inclusion criteria: 1. targeted pathologies: * flat angioma * primary hypopigmentation and early vitiligo * primary hyperpigmentation * refractory alopecia areata or congenital alopecia 2. persons concerned: * children (≥ 6 years old) suffering from one of the aforementioned pathologies * adults suffering from one of the above-mentioned pathologies * parents of children suffering from one of the aforementioned pathologies * parents of young adult patients if they live under the same roof 3. oral agreement for each person (major/minor) and, where applicable, one of the holders of parental authority (minor) exclusion criteria: 1. secondary "marks" (post-inflammatory, post-medication, post-traumatic, etc.) 2. major psychiatric disorders

Keywords: chronic dermatological disease psychology sociology disease acceptance vitiligo port wine stain hyperpigmentation alopecia areata
which factors influence the duration and the success of mechanical thrombectomy during the acute phase of cerebral infarction?

Conditions: Acute Stroke

Summary: this study aims to identify factors influencing the time span and success of reperfusion after a mechanical thrombectomy in the acute phase of cerebral infarction, and in particular the effect of intra-venous thrombolysis.

mechanical thrombectomy (mt), associated with standard iv thrombolysis (ivt) treatment, is effective during the acute phase of cerebral infarction with proximal occlusion of the anterior circulation in reducing disability at three months. mt-only treatment has only been assessed retrospectively in subgroups of controlled studies, with a significant difference in favour of the treatment. these results have led to a discussion about the benefits of mt without ivt in cases of proximal occlusion or carotid terminus occlusion. recent data are in favour of a better prognosis for patients benefiting from a combined procedure. the impact of ivt on the implementation of mt is widely disputed, in particular the speed of execution, which could be enhanced by ivt. the factors influencing the time span and success of reperfusion after an mt are still not well-known, ivt in particular. the investigators have made the assumption that ivt could have an effect on the success of mt by shortening the duration of the procedure and increasing the likelihood of satisfactory revascularisation. the investigators carried out a retrospective study based on data gathered prospectively by the franche-comté stroke registry. the investigators also considered other factors which could have affected the duration of the procedure or the rate of satisfactory revascularisation, including location of infarct, thrombus size and stroke aetiology. hypothesis: the investigators have made the assumption that ivt could have an effect on the success of mt by shortening the duration of the procedure and increasing the likelihood of satisfactory revascularisation.

Eligibility criteria:
inclusion criteria: * acute phase of cerebral infarction * all patients who had undergone an arteriography for cerebral infarction prior to mechanical thrombectomy at chru besançon * from 1st january 2015 to 31st december 2016 exclusion criteria: * patients whose procedures were interrupted (puncture failure, catheterisation of the common or internal carotid artery failure) * patients whose arteries were recanalised during the diagnostic arteriography

Keywords: stroke thrombectomy procedure time revascularisation thrombolytic therapy
blue light photodynamic therapy treatment for distal and lateral subungual toenail onychomycosis

Conditions: Toenail Onychomycosis; Distal and Lateral Subungual Toenail Onychomycosis

Summary: this research study will evaluate the safety and efficacy of using blue light photodynamic therapy (pdt) for treating toenail fungal infections.

this research study will evaluate the safety and efficacy of using blue light photodynamic therapy (pdt) for treating toenail fungal infections.

Eligibility criteria:
inclusion criteria: * patients older than 19 and younger than 70 years * give written informed consent prior to any study procedures being conducted, and candidates will authorize the release and use of protected health information (phi) * diagnosed with distal lateral subungual onychomycosis (dlso) of the great toe with both positive potassium hydroxide (koh) and positive culture growth of trichophyton rubrum * no topical treatment for dlso in the preceding 2 weeks and no oral treatment for dlso (itraconazole or terbinafine) in the preceding 8 weeks * at lease 20% of target great toe nail affected exclusion criteria: * unable to comply with the protocol (as defined y the investigator; i.e. drug or alcohol abuse or history of noncompliance) * patients with active nail disease that would confound evaluation of dlso, such as psoriasis * patients with greater than 6 toenails affected * over 90% of target great toe affected * evidence of fingernail fungal infection * patients with recurrent serious infections or have been hospitalized in the preceding 6 months for infection * patients with known history of hiv or hepatitis b or c infection * patients with severe, progressive, or uncontrolled with renal, hepatic, hematological, gastrointestinal, metabolic, endocrine, pulmonary, cardiovascular, or neurologic disease * any subject who, in the opinion of the investigator, will be uncooperative or unable to comply with study procedures
multi-national, randomized, phase iii, gcig intergroup study comparing pegylated liposomal doxorubicin (caelyx) and carboplatin vs. paclitaxel and carboplatin in patients with epithelial ovarian cancer in late relapse. (calypso)

Conditions: Epithelial Ovarian Cancer

Summary: multi-national, randomized, phase iii, gcig intergroup study comparing pegylated liposomal doxorubicin (caelyx) and carboplatin vs. paclitaxel and carboplatin in patients with epithelial ovarian cancer in late relapse. (calypso)


Eligibility criteria:
inclusion criteria: * patients with epithelial ovarian cancer in late relapse
alleviant allay-hf study

Conditions: Heart Failure

Summary: prospective, multicenter, randomized, sham-controlled, double blinded, adaptive study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using the alleviant alv1 system in patients with hfpef/hfmref.


Eligibility criteria:
inclusion criteria: 1. symptomatic hfpef/hfmref with lvef greater than or equal to 40% 2. nyha class ii, iii or ambulatory iv 3. exercise right heart catheterization\* 1. elevated left atrial pressure during exercise right heart catheterization (greater than or equal to 25 mmhg) 2. exercise pvr \< 1.8 wu 4. ongoing stable gdmt exclusion criteria: 1. advanced heart failure 2. presence of a pacemaker 3. evidence of right heart dysfunction
ole study to evaluate safety / efficacy of zd4522

Conditions: Hypercholesterolaemia

Summary: the purpose of this study is to assess the long term safety of crestor.


Eligibility criteria:
inclusion criteria: * completion of previous crestor study as listed in the protocol. exclusion criteria: * pregnant or breast feeding women, or not using appropriate contraception. * abnormal lab values as listed in the protocol.

Keywords: cholesterol hypercholesterolaemia statins
pilot study of epoetin alfa for patients having abdominal or pelvic surgery for cancer

Conditions: Anemia

Summary: this pilot study is looking at how well epoetin alfa, given in the immediate post-operative period, works in reducing anemia and the need for transfusions.

this is a pilot, single center, prospective, double blinded, randomized study comparing epoetin alfa versus placebo. eligible patients will just have undergone a major abdominal operation for malignancy (esophagectomy, gastrectomy, partial hepatectomy, partial pancreatectomy, or low anterior resection of rectum) and have a post-operative hemoglobin greater than 8 g/dl and less than 11 g/dl on post-operative day #1. on post-operative day #1 patients enrolled in the study will be randomized to receive either 40,000 units of epoetin alfa or placebo. on post-operative day #8, the patients will receive an additional dose of epoetin alfa or placebo (depending on randomization assignment and hgb level). hemoglobin, hematocrit, reticulocyte count, reticulocyte hemoglobin, and immature reticulocyte count will be measured on days 1, 4, 8, and once between post-operative days 20 and 30. pre-operatively and between post-operative days 20 and 30 patients will complete a quality of live assessment tool (fact-an) to assess their fatigue related to anemia.

Eligibility criteria:
inclusion criteria: * patients undergoing esophagectomy, gastrectomy, partial pancreatectomy, hepatic resection, or low anterior resection of rectum for malignancy * patients with hemoglobin greater than 8 and less than 11 g/dl on post-operative day #1. exclusion criteria: * patients receiving red blood cell transfusion within the first twelve hours post-operatively. * patients receiving epoetin-stimulating proteins within 30 days prior to the operation.

Keywords: digestive system surgical procedures post-operative care fatigue quality of life erythrocyte transfusion esophagectomy gastric cancer hepatectomy pancreatic cancer rectum
nimh clinical pathway in rural appalachian school-based health clinics

Conditions: Suicide Prevention; Suicide

Summary: this study will adapt and evaluate an evidence-based suicide risk screening and follow-up program in two school-based health centers in west virginia. the suicide screening program is titled the "nimh clinical pathway" and provides tools and procedures for routinely screening adolescents for suicide risk, completing risk assessments, safety planning, lethal means restriction, follow-up referrals, and other disposition planning as appropriate. investigators aim to do the following: 1. gather formative data from providers, parents, and youth to inform ways to adapt and implement the nimh clinical pathway so that it can be effectively implemented in rural, appalachian school-based health centers (sbhcs). 2. gather preliminary data regarding the feasibility, acceptability, and effectiveness of the adapted intervention.


Eligibility criteria:
inclusion criteria: * youth who are receiving services at the school-based health centers to participate * parents must be able to give legal consent for themselves and their children to participate * youth and parent must be english-speaking * youth must also be able to give signed assent to participate * youth must be cognitively and medically able to participate in study activities exclusion criteria: * youth in state custody will be excluded from study participation due to challenges related to obtaining legal consent.
armenian national registry of myocardial infarction

Conditions: ST Elevation Myocardial Infarction

Summary: this is a national, multicenter prospective observational study of patients presenting to hospitals in armenia with stemi diagnosis. the main questions it aims to answer are: * determine the rate of in-hospital mortality for the patients with stemi admitted to the participating hospitals. * compare short and long-term cv and all-cause mortality and hospitalization. * determine how professional guidelines are followed in real-world situations.

although the state program on primary percutaneous coronary intervention in st elevated myocardial infarction, which was launched in 2015 helped to drastically decrease stemi mortality rates, patients who had survived usually develop heart failure (hf) which leads to increased economic burden for the armenian healthcare system. the total duration of the study will be 24 months. the target number of the inclusion is 2500 patients. the follow-up period for enrolled patients will be 12 months.

Eligibility criteria:
inclusion criteria: 1. adult patient (≥ 18 years of age), 2. admitted to the participating centers for a stemi within 48 hours of symptom onset: characterized by a rise and fall of cardiac markers (troponins) together with st elevation in at least two contagious leads or lbbb. 3. have given signed informed consent to participate in the study. non-inclusion criteria: 1. mi occurring ≤ 48 hours after pci or cabg 2. the patient or the legal representative refused to sign the informed consent exclusion criteria: withdrawal of the informed consent

Keywords: stemi myocardial infarction acute coronary syndrome cv mortality biobanking
metabolic and vascular effects of statins in untreated dyslipidemic diabetic patients

Conditions: Type 2 Diabetes; Diabetic Dyslipidemia

Summary: type 2 diabetes (t2d), because of impaired glucose regulation and consequent hyperglycemia, promotes the development of coronary heart disease. secondary dyslipidemia is often associated with t2d and enhances the risk of cardiovascular complications. hmg-coa reductase inhibitors (statins) are selectively administrated for the treatment of dyslipidemia, leading to a significant reduction of cardiovascular risk. more recently, revisions to guidelines have established a lower therapeutic ldl cholesterol goal for diabetic patients, requiring the administration of higher dose of statin. however, it is unclear whether high dose statin therapy could affect glycemic control in diabetic patients. moreover, data regarding the effects of statins on insulin-resistance and endothelial function are controversial.


Eligibility criteria:
inclusion criteria: * type 2 diabetes in good glycemic control, treated with metformin alone. * untreated dyslipidemia. * bmi \<30. exclusion criteria: * history of cancer. * history of cardiovascular diseases. * any other acute or cronic illness which requires administration of steroids or other drugs able to interfere with glucose metabolism.

Keywords: statins administration in diabetic dyslipidemia
imaging lens deposits in exfoliation syndrome

Conditions: Exfoliation Syndrome; Primary Open Angle Glaucoma; Cataracts

Summary: the purpose of this study is to use a special eye imaging technique, anterior segment optical coherence tomography (as-oct), to image the lens (the curved, transparent part of the eye that helps you to see clearly by directing images of light onto the back of your eye) and note any changes in exfoliation syndrome. exfoliation syndrome is a common condition that has many ways of showing up in the eye, including the formation of deposits in the eye, shakiness of the lens that can complicate cataract surgery, and a higher chance of developing a type of glaucoma called exfoliation glaucoma. in this study we plan to collect images and measure exfoliation deposits on the lens with as-oct, which can take high resolution pictures of the eye without requiring contact with the eye. we will compare lens images of subjects with exfoliation syndrome to those of subjects with primary open angle glaucoma and cataracts. this type of imaging could be used in patients with known diagnosis of exfoliation syndrome to track disease progression and see how they respond to possible treatments. we also hope that with this imaging technology we can detect early changes in currently unaffected eyes, which could be useful for predicting which patients may develop the disease.


Eligibility criteria:
inclusion criteria: * diagnosis of exfoliation syndrome, primary open angle glaucoma (poag), or cataracts exclusion criteria: * unable to provide or sign consent * pseudophakia * other prior intraocular surgery * other eye diseases other than refractive error