Kornimate/medical-research-clean huggingface dataset:
relationship between lifestyle indicators and cardiovascular clinical parameters

Conditions: Cardiovascular Diseases; Lifestyle; Nutrition, Healthy; Physical Inactivity; Stress; Sleep

Summary: the goal of the study is to build a register accruing data derived from the compilation of the questionnaire about lifestyle for a population both of adults and of young boys and girls. the investigators are confident that in this way they will be able to expand the database they already have. the investigators will be able to increase the strength of the correlations between ls indices and health indicators. in particular, the investigators will emphasize the relationship between physical activity, stress, and diet quality on one hand, and on the other, they will focus on physiological parameters, like arterial pressure, gluco-lipid profile, and possible pathologies.


Eligibility criteria:
inclusion criteria: - ability to provide informed consent in compliance with the rules of good clinical practice and current national regulations exclusion criteria: * inability to fill in the questionnaire * inability to provide informed consent * unwillingness to participate in the study
risk factors of depression, anxiety and eating disorder after bariatric surgery

Conditions: Depression; Anxiety; Eating Disorders; Bariatric Surgery

Summary: the goal of this observational study is to investigate and determine rate of occurrence and associated risk factors of depression , anxiety , eating disorder after bariatric surgery. participants will undergo psychometric tests.

the aim of this study is to investigate and determine rate of occurrence and associated risk factors of depression , anxiety , eating disorder after bariatric surgery . and its correlation to postoperative changes in weight . all data from the subjects will be obtained through direct interviews of postoperative patients all subjects will be submitted to : 1. obtaining detailed history of age , sex , socioeconomic level , work , educational level , marital status , functionality of the patient , special habits (smoking index , alchohol and substance abuse , feeding habits , exercise ). evaluating the family history of obesity , psychiatric disorder , bariatric surgery searching for early and late complications of bariatric surgery : dumping syndrome , malnutrition , vomiting , hernias , redundant ght loss (by wieght skin , skin infection , vomiting . determining the type of surgery. degree of obesity of postoperative patients evaluated by body mass index medical comorbidities hypertension , diabetes , chronic kidney disease , chronic liver disease , ischemic heart disease , obstructive sleep apnea , gastric reflux , dermatological disorders psychometric evaluation hamilton anxiety rating scale hamilton depression rating scale eating disorder evaluation. eating attitudes test-26

Eligibility criteria:
inclusion criteria: * study sample of humans who had bariatric surgery. * subjects with postoperative time of ≥ 3 months * male or female aged between 18:60 years. exclusion criteria: * illiterate patients. * patients have dementia or psychosis. * age below 18 or above 60 years. * patients refused to give written informed consent
water as therapy in autosomal dominant polycystic kidney disease (adpkd)

Conditions: Autosomal Dominant Polycystic Kidney Disease

Summary: autosomal dominant polycystic kidney disease (adpkd) is the most common single gene disorder that is potentially fatal. adpkd is caused by mutations in either of two genes (pkd1, pkd2). cysts begin to develop primarily in renal collecting tubules in utero and continue to form and expand throughout the patient's life. one of the goals of the study is to formulate a water prescription for use in clinical trials to determine the effect of sustained water diuresis on the progression of adpkd.

the proposed study will devise a quantitative model to estimate the amount of water an individual would need to ingest in order to lower the 24 h mean urine osmolality to a level below plasma (\~285 mosm/kg). this osmolality goal is chosen because the 24h median urine osmolality of humans is ordinarily \~753 mosm/kg, much greater than 285 mosm/kg (6, 7). in other words, normal humans are usually anti-diuretic during waking hours and while asleep. median 24h urine volume is \~1225 ml (range 1051 - 2270). in temperate climates the insensible losses of water in sweat, respiration and stool are nearly balanced by the water ingested in solid and semi-solid foods and derived from metabolism. thus, daily urine volume measured upon arising in the morning is a reasonably good indicator of the volume of fluids drunk over the preceding 24 h.

Eligibility criteria:
inclusion criteria: * adpkd verified by ultrasound, ct or mri, family history or physical exam * normal creatinine clearance, calculated by cockroft-gault formulat * good general health * controlled blood pressure, \< 140/90 * absence of urinary tract symptoms such as dysuria, hesitancy, diminished flow exclusion criteria: * azotemia * uncontrolled hypertension * urinary tract symptoms, dysuria, hesitancy, diminished flow, gross hematuria * diabetes mellitus, cancer, hematologic disorder * unable to follow directions * solitary kidney * history of chf, liver dysfunction or hyponatremia * currently taking diuretics * nephrotic range proteinuria (3.5 g/day)

Keywords: adpkd
concordance autofevg

Conditions: Echocardiography; Medicine, Emergency; Technology Assessment, Biomedical; Heart Diseases

Summary: clinical ultrasound has become essential in emergency medicine. the guidelines are to use of echocardiography in specific contexts: dyspnea, hypotension or chest pain. the evaluation of left ventricle ejection fraction (lvef) is one of the basic objectives of echocardiography. the reference assessment in emergency medicine is visual assessment. it suffers from poor inter-observer reproducibility. pocket ultrasound scanners seem to meet the constraints of point-of-care ultrasound. a new tool is available on a pocket ultrasound device: the automatic evaluation of lvef. its interest could be to have a better inter-observer reproducibility than visual evaluation.


Eligibility criteria:
inclusion criteria: * patient over 18 years of age * management in the investigator centre * admitted for dyspnea or hypotension or chest pain exclusion criteria: * age \< 18 years * patient not benefiting from a social security system * patient deprived of liberty * patient under the protection of justice, under guardianship or curatorship * patient refusing to participate in the study * inability to provide the patient with informed information
innovation in non invasive ventilation in copd patients treated by long term oxygen therapy

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the aim of this study is to investigate the efficacy of non-invasive ventilation (niv) on nocturnal hypoventilation in patients with chronic obstructive pulmonary disease (copd) who are on long term oxygen therapy (ltot) at home.

this is a prospective, randomized, open labelled study. the primary outcome is nocturnal transcutaneous co2 (ptco2) after 3 months of non-invasive ventilation. three hundred copd patients on ltot will be screened and assessed by pulmonary function tests, blood gases and nocturnal ptco2 at their home. this will allow the determination of the prevalence of nocturnal hypoventilation in copd patients on ltot (a secondary outcome) and to select patients who meet the inclusion criteria for the rct and randomization to niv + ltot or to continue ltot alone (n=38). patients will undergo the same assessments at the end of the three-month intervention period.

Eligibility criteria:
inclusion criteria: * chronic obstructive pulmonary disease (copd) * on long term oxygen therapy (ltot) * affiliated to french social security system or equivalent * informed consent signed exclusion criteria: * diurnal ptco2 \>55mmhg * patient who has had an exacerbation of copd requiring a change in management or treatment in the last 4 weeks prior to the inclusion visit. * pregnant or breathfeeding women * prisonners or persons who require protection by the law * exclusion period from another study * persons who, according to the investigator, are expected no to meet all study obligations

Keywords: copd oxygenation long term non invasive ventilation nocturnal hypoventilation
screening for 3-d visual disorders in preschool children

Conditions: Amblyopia; Strabismus; Anisometropia

Summary: visual screening is necessary among pre-school children as they found themselves in a critical period of visual developement. to date, there are no national vision screening program that has been implemented nationwide. vision is a pilot feasibility multicentric cluster study comparing the sensitivity of "afsop 3 dimensional visual screening protocol in a population of 3 to 4-year-old pre-school children conducted in 4 kindergarten preschools in paris with gold-standard ophthalmic examination confirmation.

visual screening is necessary among pre-school children as they found themselves in a critical period of visual developement. to date, there are no national vision screening program that has been implemented nationwide. methodology: the "association française de strabologie et d'ophtalmologie pédiatrique" afsop proposed criteria based on a 3-dimensions visual screening to assess whether or not a child presents risk factors of amblyopia such as ametropia, strabismus and anisometropia. vision is a pilot feasibility multicentric cluster study comparing the sensitivity of "afsop 3 dimensional visual screening protocol in a population of 3 to 4-year-old pre-school children conducted in 4 kindergarten preschools in paris with gold-standard ophthalmic examination confirmation. expected results: we assume that a vision screening operated with the afsop 3 dimension screening recommendations and conducted by paramedical actors such as orthoptists will prove more sensitive and easier to implement on a national scale.

Eligibility criteria:
inclusion criteria: * children aged 3 to 4 years * enrolled in kindergarten in the first section * in the 19th district of paris * who should benefit from visual screening via the school medical service exclusion criteria: * children who do not speak french * children who are physically or cognitively unable to participate in the screening
the effect of bench-model training in cognitive learning in the operating room

Conditions: Sensitivity Training Groups

Summary: based on the motor learning theories, it is hypothesized that bench-model training will allow junior residents to be more interactive than trainees lacking similar active hands-on training.


Eligibility criteria:
inclusion criteria: * students enrolled in first or second year of their residency from a variety of division exclusion criteria: * residents from higher year

Keywords: orthopedics bone fixation
safety and efficacy of sufentanil administration by paramedics in acute trauma

Conditions: Injury Traumatic; Pain, Acute

Summary: the safety and efficacy of competence of paramedics to administer sufentanil intravenously in adult acute trauma patients without presence or without phone-call consult with an emergency medical doctor will be assessed in this observational study. condition or disease: pain in trauma or injury. intervention/treatment: sufentanil administered by paramedics after the phone call consultation of medical doctor versus sufentanil administered by paramedics based on their competency, without consultation of medical doctor.

the administration and indication of an opioid analgesics is carried by a medical doctor in most european emergency services. however, trips to majority of less serious traumas are realized by ambulances with paramedic crews without a medical doctor present on site. this study will assess the new competence of paramedics to administer opioid analgesics without presence or phone-call consult with an emergency medical doctor. this study will address the safety and efficacy of sufentanil administered by the paramedics in the field to patients with acute trauma without any consultation with medical doctors. this study will complement the recently published data of the previous study, which, however, took place during the outbreak of covid-19 and this lockdown situation could have distorted the frequency and nature of the observed cases.

Eligibility criteria:
inclusion criteria: * acute trauma with severe pain (vas/nrs \> 4) * age \> 18 years * conscious patient (gcs = 15; alert in avpu) * haemodynamically stable patient (\> 100mmhg of systolic blood pressure, \> 60/min of heart rate) exclusion criteria: * ems doctor on site * paediatric patient (less than 18 years) * predominantly chronic but not acute pain * incomplete documentation * other than traumatic reasons for opioid administration (eg. acute coronary syndrome)

Keywords: sufentanil acute trauma pain paramedic competence prehospital
reduction of intraocular pressure after i-stent by-pass implantation in eyes with open angle glaucoma

Conditions: Glaucoma

Summary: purpose of this study is to exam the hypotensive effectiveness of i-stent implantation depended on number of antiglaucoma eye drops at baseline.

the scientific aim of the project is to estimate the average reduction of intraocular pressure (iop) in relation to the initial number of antiglaucoma drops at the end of 12 months observation period. the subject must suffer from glaucoma and cataract at the same time, and qualify for a cataract surgery. the group will be composed of 40 patients of the ophthalmology clinic of the medical university of białystok qualified for planned cataract removal surgery. they will be surgically implanted an i-stent by-pass during phacoemulsification.

Eligibility criteria:
inclusion criteria: * co-existing glaucoma and cataract (nc1, nc2) classified by means of the locs iii scale (lens opacity classification system iii) * patients with primary open-angle glaucoma (poag), pseudoexfoliative glaucoma (pgx) and normal tension glaucoma (ntg), with topical hypotensive treatment * written consent to involvement and participation in the study for a period of at least 12 months was obtained from all patients after they had first been informed of the nature of the procedure and other surgical alternatives exclusion criteria: * no consent to participation in the study * prior surgical and laser procedures in the area of the eye * narrow- or closed-angle glaucoma * post-inflammatory or post-traumatic secondary glaucoma * chronic illness of the cornea or optic nerve * advanced macular degeneration * active inflammatory process * pregnancy * systemic steroid therapy

Keywords: i-stent glaucoma surgery minimally invasive glaucoma surgery
influence of mandibular nerve lateralization on nutrition and speech

Conditions: Alveolar Bone Loss; Bone Deformity

Summary: this study aimed to evaluate the effects of lip numbness on the nutritional status and speech of patients who underwent inferior nerve lateralization for dental implant placement in the mandibular posterior region. for this purpose, observational follow-up of two groups of patients will be performed. the control group will include patients with standard implant placement in the mandibular posterior region. the test group will consist of patients with implant placement in the mandibular posterior region with inferior alveolar nerve lateralization. the patients will be evaluated before implant surgery and followed up for four months until the final prosthesis is placed. changes in nutritional status, masticatory performance and speech abilities will be assessed during this process.


Eligibility criteria:
inclusion criteria: * a standard dental implant with or without lateralization of the inferior alveolar nerve in the posterior region of the mandible at the marmara university faculty of dentistry, department of oral, dental and maxillofacial surgery clinic. * the patient accepted to participate in the study and gave written/verbal consent exclusion criteria: * dental implant placement in the posterior region of the mandible with additional surgical methods (onlay/inlay graft, directed tissue regeneration, etc.) other than nerve lateralization. * patients had a neurosensory disorder in the maxillofacial region before implant surgery

Keywords: dental implants mandibular nerve nutritional status
infiltration in the region of the palatine ganglion spheno by ropivacaine on postoperative pain

Conditions: Pain

Summary: endoscopic sinus surgery (ess) is a prevalent surgical procedure. it is required in many chronic rhinosinusitis for whom the medical treatment failed. in order to improve the postoperative management of patients treated with ess, we aim to assess the analgesic action of local injection of ropivacaine in the nasal fossa.

a prospective randomized double blind placebo controlled study was designed. local injection of ropivacaine or placebo was conducted at the end of the surgical procedure in both nasal fossa through endoscopic view in the sphenopalatine region. pain was measured in the postoperative course with visual analogic scale in the recovery room and the rhinologic department.

Eligibility criteria:
inclusion criteria: * patients requiring endoscopic sinus surgery * asa score 1 or 2 * patients with health care insurance * approved consent exclusion criteria: * any sinonasal malignant tumor * renal failure, hepatic disorder, respiratory deficiency, cardiovascular diseases * neurologic disorders * alcohol or drugs addiction * preoperative facial pain from an extranasal origin * coagulation disorders * antidepressive treatment

Keywords: sinus surgery sphenopalatin ganglion ropivacaine local anesthesia
effects of active release technique (art) on pectoralis minor tightness in post mastectomy women.

Conditions: Postgastrectomy Syndrome

Summary: the aim of this research is to determine the effects of active release technique (art) on pectoralis minor tightness in post mastectomy women. randomized controlled trials will be done at nuclear medicine, oncology and radiotherapy institute (nori) hospital. the sample size will be 60. the subjects were divided in two groups, with 30 subjects in group a and 30 in group b. study duration was of 6 months. sampling technique applied was non probability convenience sampling technique. only women aged 40-60 years with mastectomy (unilateral/ bilateral/ partial/ radical) and postoperative chemotherapy/ radiation therapy were included. tools used in the study are numeric pain rating score (nprs), shoulder pain and disability index (spadi), vernier caliper and rigid standard plastic transparent right angle. data was analyzed through spss 21.

breast cancer may be a malignant neoplasm, an abnormal growth (carcinoma) originated in breast tissue that invade the encompassing tissue, grows infiltrative and destructive, and may metastasize.it is outlined pathologically by location of origin within the breast (e.g. ducts, lobes), size of the tumor, standing of the nodes, and also the presence of markers indicating tumor staging. mostly, early-stage breast cancer diagnosed in women undergo surgical procedures, nearly half withstand breast-conserving surgery and one third experience mastectomy. it is generally believed that physiotherapy aims to aid recovery and prevent complications following mastectomy however no well-designed, randomized controlled trial has investigated the effect of active release technique (art) specifically on pectoralis minor in post-operative breast cancer women. hence, a physiotherapy rehabilitation plan of care consisting of patient education, early mobilization along active release technique (art) may prevent postoperative complications like chest tightness and reduced shoulder mobility. this will enhance muscular relaxation, improve restricted mobility, and will result in improved quality of life as compared to standard care or conventional treatment alone.

Eligibility criteria:
inclusion criteria: * women complaining chest tightness * mastectomy (unilateral/ bilateral/ partial/ radical) * postoperative chemotherapy or radiation therapy exclusion criteria: * tumor metastasis with other tissue/ organ. * underlying cardiac issues. * shoulder joint pathology before surgery. * post mastectomy pain syndrome (pain beyond 3 months).

Keywords: pectoralis minor tightness post mastectomy women active release technique breast cancer
pedaling at a low-moderate intensity during chemotherapy administration

Conditions: Colorectal Cancer; Exercise, Aerobic; Chemotherapy; Chemotherapeutic Toxicity

Summary: the purpose of this study is to evaluate the feasibility of completing a low-moderate intensity pedaling session concurrent to chemotherapy treatment for colorectal cancer. secondary objectives for this study consist of evaluating the role of pedaling on sarcopenia rates, quality of life markers, chemotherapy side effects, rate of hospital admissions, and treatment delays.


Eligibility criteria:
inclusion criteria: * patients with diagnosed colon or rectal cancer with previous surgical intervention and planned intravenous chemotherapy treatment (folfox or folfiri). * ecog performance status of grade 0-2. exclusion criteria: * limited functional status, demonstrated by an ecog performance status of grade 3-5. * severe cardiac history or comorbidities (i.e. have a cardiac defibrillator or have a history of heart failure, clinically significant aortic stenosis, cardiac arrest, uncontrolled angina, uncontrolled arrhythmias, major heart surgery, stroke, or pulmonary embolus). * chest pain or severe shortness of breath at rest or with physical activity. * orthopedic impediments to exercise (i.e. joint immobility or lower extremity lymphedema). * limitations to sustained exercise (i.e. bone metastases in the femur neck). * severe arthritis (i.e. osteoarthritis or rheumatoid arthritis).

Keywords: pedaling sarcopenia quality of life
long-term heart-specific mortality in the presence of competing risks among patients with non-metastatic gastric adenocarcinoma undergoing resection and chemotherapy

Conditions: Long-term Heart-specific Mortality in the Presence of Competing Risks Among Patients With Gastric Adenocarcinoma Undergoing Resection and Chemotherapy

Summary: in this population-based cohort study, data on patients diagnosed with nmgac in 2004 through 2016, managed with resection and chemotherapy, followed up until the end of 2016, and surviving ≥1 month were retrieved from the us surveillance, epidemiology, and end results-18 program. cumulative mortality functions were calculated. prognostic factors for heart-specific mortality were evaluated using both multivariable-adjusted fine-gray subdistribution and cause-specific hazard functions.


Eligibility criteria:
cases of non-metastatic gastric adenocarcinoma (nmgac) were defined as patients with microscopically-confirmed first primary invasive adenocarcinoma of the stomach (international classification of diseases for oncology, third edition (icd-o-3) code: c16) without distant metastasis. only those who underwent resection in january 2004 through december 2016 were included. cancers of other histology types including squamous cell carcinoma, gastrointestinal stromal tumor or sarcoma, neuroendocrine tumor or carcinoid, lymphoma, and germ-cell tumor were ineligible, as were patients with non-gastric cancers involving the stomach, with benign or in situ tumors, or with other malignancies before gastric cancer. we further excluded patients with diagnosis based on death certificate only or autopsy, with missing follow-up period, survival status, or cause of death, or with unknown metastasis status. cancers with distant metastasis were excluded since resection is not routinely recommended for them. data before 2004 were not included, as the tnm stage information was unavailable. to minimize the effect of perioperative events on survival, we excluded patients surviving \<1 month. no restrictions were applied to age, and patients ≥80 years only comprised 5% of those receiving both resection and chemotherapy.