Kornimate/medical-research-clean huggingface dataset:
the application and analysis of hhhfnc in walking test of pulmonary rehabilitation

Conditions: COPD; Pulmonary Disease; Rehabilitation

Summary: the aim of this study is to investigate the use heated humidified high-flow nasal cannula (hhhfnc) in pulmonary rehabilitation and analysis of cardiopulmonary parameters in adult patients.

objectives： the aim of this study is to investigate the use heated humidified high-flow nasal cannula (hhhfnc) in pulmonary rehabilitation and analysis of cardiopulmonary parameters in adult patients. background： recently, hhhfnc has been used in both adult and neonates with post-extubation respiratory support. studies indicate that hhhfnc has similar efficacy compared to non-invasive positive pressure ventilation and superior than conventional oxygen therapy. six-minute walking test (6-mwt) is a standardized laboratory tests to evaluate the endurance capacity in adult patients. it helps clinician to modify the treatment plan. cirio, et at. has been shown hhhfnc may improve the exercise performance in severe chronic obstructive pulmonary disease (copd) patients with ventilatory limitation. study design： this is a prospective clinical trial in a pulmonary rehabilitation out-patient department (2018.08.01-2019.07.31).。 methods： patents with copd who done pulmonary function test will enroll to this study. left-side heart failure, copd acute-exacerbation (ae) within 3 months, diagnosed neuromuscular disease, and unable to perform 6-mwt will be exclude. the data will be collected for and analyzed. effect： investigators expect the exercise performance; cardiopulmonary function will be improve under hhhfnc support. we hope the application of hhhfnc in adult patient with pulmonary rehabilitation could enhance the quality of life. key words： chronic obstructive pulmonary disease; heated humidified high-flow nasal cannula; pulmonary rehabilitation, six-minute walking test.

Eligibility criteria:
inclusion criteria: * copd with performed pulmonary function test exclusion criteria: * left-side heart failure * copd exacerbation within 3 month * diagnosed neuromuscular disease * unable to perform 6-mwt

Keywords: chronic obstructive pulmonary disease heated humidified high-flow nasal cannula pulmonary rehabilitation six-minute walking test
inflammatory markers and cognitive function in major depression

Conditions: Major Depression

Summary: major depression is accompanied by cognitive changes as well as alterations in multiple physical functions. the inflammatory system is altered generally toward a pro-inflammatory state. antidepressants are associated with a decrease in this proinflammatory state. this study aims to generate pilot data concerning a possible link between cognition, inflammation and response to treatment. the cognitive function of subjects with major depression will be tested before and after treatment with duloxetine. inflammatory markers will be measured at both time points.


Eligibility criteria:
inclusion criteria: * age 20-50 primary diagnosis of major depression ability to give informed consent exclusion criteria: * neurologic disorders affecting cognition * unstable or untreated medical disorders * medical disorders associated with pain * recent pregnancy or delivery * psychiatric disorders other than md which are the primary focus of treatment * treatment with antidepressants in the past 4 weeks

Keywords: depression inflammation cognition pain allostatic load
vitamin d metabolism in senescent cardiac surgery patients

Conditions: Coronary Artery Bypass Grafting; Heart Valve Surgery

Summary: advanced age is associated with an increase in postoperative morbidity and mortality in cardiac surgery patients. in detail, compared with younger patients those aged 75 years and older have significantly higher rates of in-hospital mortality, cerebrovascular events, pneumonia, and dialysis. in addition, older cardiac surgery patients have longer mechanical ventilation times. vitamin d exerts several beneficial effects on the cardiovascular system. moreover, it has immuno-modulatory and anti-inflammatory properties. the hormonal form of vitamin d, 1,25-dihydroxyvitamin d, is an independent predictor of mid-term mortality in cardiac transplant recipients. 1,25-dihydroxyvitamin d also predicts mid-term and long-term mortality in patients with a high risk for cardiovascular disease. mild renal impairment, insufficient vitamin d levels, and secondary hyperparathyroidism are common in frail elderly individuals. the present study aimed to investigate whether cardiac surgery exerts age-dependent effects on calciotropic hormones, components of the immune system, and inflammatory processes.it is hypothesized that (i) baseline 1,25-dihydroxyvitamin d levels are lower in patients \<= 75 years of age compared to younger patients, (ii) cardiac surgery results in a transient decrease in circulating 1,25-dihydroxyvitamin d, and (iii) that the decrease in 1,25-dihydroxyvitamin d is probably more pronounced in older than in younger cardiac surgery patients.


Eligibility criteria:
inclusion criteria: * age: \ = 75 years * first elective cardiac surgery (bypass or combined bypass and heart valve surgery) * written informed consent exclusion criteria: * emergency cardiac intervention * primary hyperparathyreoidism * primary and secondary hypoparathyreoidism * daily vitamin d supplementation \> 10 micrograms

Keywords: vitamin d cardiac surgery inflammation immune system age
sporadic inclusion body myositis natural history study

Conditions: Sporadic Inclusion Body Myositis; Inclusion Body Myositis

Summary: this is a prospective natural history study on patients with clinically defined sibm. participants will be assessed every 6 months over two years (five visits total). we will include 150 participants, enrolled across 13 sites, with sporadic ibm, diagnosed according to established criteria.

this is a prospective natural history study on patients with clinically defined sibm. participants will be assessed every 6 months over two years (five visits total). we will include 150 participants with sporadic ibm, diagnosed according to established criteria. participants will require an routine serum sample via blood draw to evaluate for nt5c1a antibody status. this testing will be performed at washington university school of medicine in the neuromuscular laboratory. investigators will be blinded to antibody status. a subset of participants (40) will undergo a muscle biopsy at the baseline visit. aim 1. to determine for the first time whether nt5c1a antibodies mediate disease progression over a two-year interval in patients with sibm. we will perform a prospective, non-interventional, observational study on patients with sibm with follow up and evaluations every 6 months over a two-year time frame. primary analyses are: 1) the rates of disease progression and severity as measured by rates of decline in ibm functional rating scale (ibmfrs) score and timed get up and go (tug); 2) the presence or absence of serum antibodies to nt5c1a; and 3) the presence and frequency of variant t-cells in the serum and skeletal muscle. aim 2. to perform a detailed morphological, histochemical and immunohistochemical analysis of fresh muscle biopsy specimens obtained from a subset of patients with sibm. aim 3. to characterize the distribution of "immunosenescent" lymphocytes in circulating blood from patients with sibm. aim 4. to quantify the decline in the respiratory function of sibm patients.

Eligibility criteria:
inclusion criteria: 1. ages 40 years and older 2. fulfills enmc 2011 criteria of clinically definite or probable sporadic inclusion body myositis (sibm) 3. disease onset is within the past 10 years of the time of baseline visit 4. able to participate and comply with study related procedures 5. able to provide written consent exclusion criteria: 1. current or very recent use (within last 6 months of the baseline visit) of immunomodulation or immunosuppression therapy. 2. current or very recent use (within last 90 days of the baseline visit) of an investigational medication or therapy. 3. co-existing significant medical or surgical conditions that, in the opinion of the investigator, will influence study participation or alter natural history.
determination of reference values for diluted russell's viper venom time (drvvt) specific to pregnant women (grapl)

Conditions: Normal Pregnancy

Summary: pregnancy is associated with significant changes in several aspects of haemostasis, especially an imbalance between procoagulant and anticoagulant factors. these changes contribute to creating a state of hypercoagulability, mainly at the end of pregnancy and during the post-partum period, protecting pregnant women from delivery haemorrhage, but exposing them to a major thromboembolic risk. vascular diseases of pregnancy (vdp) are obstetric diseases which are linked to an ischaemic origin associated with placental thrombosis. these include pre-eclampsia, retroplacental haematoma, intrauterine growth retardation and even foetal death in utero. a number of risk factors have been identified for these vdps, some of which have extremely serious consequences, the main one being antiphospholipid syndrome (aps). the diagnosis of vdp in a current or previous pregnancy requires close monitoring and joint management by an obstetrician, haemostasis physician, internist and medical biologist, particularly in terms of pre, peri- and post-partum anticoagulation in patients at increased risk of thromboembolism. the aim of treating aps during pregnancy is : to reduce the occurrence of maternal arterial or venous thrombotic complications in one hand and in the other hand to reduce the occurrence of obstetric complications, which are responsible of a significant morbimortality rate. the detection of a possible aps during pregnancy will therefore determine the specific management of patients. the latest guidelines from the groupe français d'etude sur l'hémostase et la thrombose (gfht) in 2022 recommended a diluted russell's viper venom time (drvvt) and an activated partial thromboplastin time (aptt) measured using a sensitive reagent such as silica (sct) should be used to assess the presence of la.

please remove all personal pronouns. for example, please change "we" to "the investigators" and "you" to "participants." the "control + find" function (ctrl+f) can be used to locate personal pronouns throughout the record.

Eligibility criteria:
inclusion criteria: control group : * patients with normal pregnancies at the hcl. * affiliation to a social security regime case group : * patients followed at the hcl who had an increased drvvt ratio during pregnancy, investigated as part of the development of vdp during pregnancy. * affiliation to a social security regime exclusion criteria: * history of thromboembolic disease * history of autoimmune disease * history of vdp

Keywords: pregnancy thrombophilia antiphospholipid syndrome vascular diseases of pregnancy diluted russell viper venom time
a randomized study to establish the efficacy of oral ice exposure during oxaliplatin infusion in preventing oral cold sensitivity

Conditions: GI Patients on Oxaliplatin Containing Regimen

Summary: the main purpose of this study is to evaluate whether exposure to ice chips in the mouth (oral ice chips) during oxaliplatin treatment prevents or reduces symptoms of cold sensitivity.


Eligibility criteria:
inclusion criteria: * individuals ≥18 years of age will be enrolled. * patients must have histologic confirmation of a solid tumor malignancy that will be treated with a regimen that contains full-dose oxaliplatin. * patients may be receiving treatment in the neoadjuvant, adjuvant or metastatic setting. * patients must be treatment-naïve to platinum-agents at the time of enrollment. prior treatment with non-platinum agents is permitted. exclusion criteria: * any active intraoral infection, including yeast infection (thrush) or active oral herpes simplex virus at the time of enrollment. * patients may not have dentures. * patients may not have a disorder that may result in altered taste sensation at baseline. this includes but is not limited to: persistent dry mouth.
colon cancer surgery in the aged; postoperative outcome, functional recovery and survival.

Conditions: Colon Cancer

Summary: patients aged \> 80 years represent an increasing proportion of colon cancer diagnoses. it is important to have relevant and trustable data concerning elderly colorectal cancer patients surgery and postoperative morbidity, functional ability, life quality and survival numbers. with possibly compromised health status and functional decline the benefits of surgical management and outcomes can diminish life quality and overall survival. with proper patients selection, preoperative health evaluation and thus patient information, colorectal cancer surgery can be performed with lower morbidity and mortality rates with comparative survival numbers. the aim of this prospectively collected, observational study is to acquire data from colorectal cancer surgery in aged over 80 years and perform statistical analysis of the preoperative risk factors affecting postoperative morbidity, functional recovery, mortality and overall survival.

9 finnish hospitals including three university hospitals participate in the study. the data is collected from the hospitals using a specially designed and secure web application (redcap). the preoperative patients' data include comorbidities, clinical frailty scale (cfs) and functional status, postoperative surgical and medical outcomes and survival data. the patient questionnaire is based on the g-8 geriatric screening tool and mna-short form. the questionnaire is filled out preoperatively and 1, 3, 6 and 12 months postoperatively. the patient data concerning procedures is collected from the hospitals prospectively recording data. mortality data on causes of death are obtained from statistics finland. all colon cancer patients aged over 80 years with curative disease (stage i-iii) are included. patients with metastatic disease or severe alzheimer disease are excluded. they are treated either non-operatively or with curative resection or palliative procedure. patients fill out the approval form. the study is acknowledged by the ethics committee of the participating hospitals.

Eligibility criteria:
inclusion criteria: * primary colon cancer, which is surgically treated with curative intent (stage i-iii) exclusion criteria: * metastatic colon cancer, severe dementia, life expectancy less than six months

Keywords: colon cancer surgery octogenarian postoperative outcome
behavior change intervention for cardiovascular risk reduction among people experiencing homelessness

Conditions: Heart Diseases; Diabetes Mellitus, Type 2; Pre-diabetes; Hypertension; Hyperlipidemias

Summary: this single-arm trial of the cardiovascular risk reduction among people experiencing homelessness (cv-homes) intervention alone (n=8) will test the perception and feasibility of anticipated study procedures.

this study is of a set of studies with an overall goal to develop and pilot test a collaborative care intervention using motivational interviewing and behavioral activation alongside education and psychosocial support to improve medication adherence tailored to the experiences of people experiencing homelessness and cardiovascular health risks (cv-h). our team's central hypothesis is that medication adherence and cardiovascular self-care (and eventual glycemic control, cholesterol control, health care use/cost) will improve with an intervention tailored to the unique context of cv-h. this protocol addresses a pilot study to test patient perceptions of the feasibility and acceptability of study procedures and refine the cv-homes treatment manual through test cases (n=8). with a hypothesis that the cv-homes manual and study procedures will be feasible and acceptable to cv-h as measured by self-report and post-treatment interview.

Eligibility criteria:
inclusion criteria: * age 18 yrs. or older * english-speaking * living at catholic charities' endeavors residence (minneapolis, mn) * self-reported diagnosis of moderate or high cvd risk, defined as being told by a medical professional that the participant has hypertension, heart disease, hypercholesterolemail, prediabetes, or type 2 diabetes * plan to stay in local area or be reachable by phone for the next 16 weeks * willingness to work on one or more cvd risk reduction behavior change exclusion criteria: * active intoxication * active psychosis * presence of a legal guardian * pregnant or lactating people

Keywords: cardiovascular health homeless persons delivery of health care, integrated primary care social determinants of health
observational study to investigate the occurrence of bleeding in postmenopausal women treated with estradiol/neta for 12 months

Conditions: Menopause; Postmenopausal Bleeding

Summary: this study is conducted in europe. the primary aim of this observational study is to investigate the occurrence of bleeding in women taking 0.5 mg estradiol and 0.1 mg norethisterone acetate (neta) for 12 months.


Eligibility criteria:
inclusion criteria: * informed consent, permitting the data to be processed within the scope of the study, is obtained from the patient before any study-related activities * postmenopausal amenorrhoeic women * treatment with previously combined hrt discontinued at least 3 months prior to start of 0.5 mg estradiol and 0.1 mg norethisterone acetate treatment
compliance and administration technique in topical drug therapy of glaucoma

Conditions: Glaucoma

Summary: clinic-based evaluation of patients compliance with topical medications in the treatment of glaucoma. also assessing effectiveness of delivery techniques among these patients.


Eligibility criteria:
inclusion criteria: glaucoma 18 years of age or older exclusion criteria: recent ocular surgery

Keywords: glaucoma compliance therapy administration technique
analysis of factors determining increase of serum sodium in hyponatremic patients

Conditions: Hyponatremia

Summary: the aim of this study is to further analyse the dataset of the hyponatremia registry, a multicenter, prospective, observational study conducted between september 2020 and february 2013 in the united states of america and the european union. the primary interest was to provide evidence to investigators' hypothesis that baseline sodium levels are a predominant factor determining the rapidity of sodium increase irrespective of the given treatment. further investigators aimed to identify other independent predictors of the increase of plasma sodium upon treatment.

hyponatremia is the most common electrolyte disorder in outpatients and hospitalized patients. overly rapid sodium increase is associated with increased risk for osmotic demyelination. smaller analyses have suggested that the slope of the sodium increment is higher with lower baseline sodium levels but this has not been confirmed in large datasets. investigators have recently published the results of analysis on patients from the otsuka hn-registry on thiazide-induced hyponatremia (cooperation with otsuka). in that dataset was founded the same association and there had been hints that this relationship holds true for all kinds of treatment including no treatment at all. investigators took the datasets of those patients presenting with hyponatremia that could be classified into one etiology group by the treating physician for further analysis. patients with euvolemic, hypervolemic, hypovolemic or thiazide-associated hn were included in investigators' analysis. furthermore investigators only considered those cases in which the patient record provided at least one documented plasma \[na+\] within \<25 hours after the first plasma \[na+\] ≤130meq/l had been measured. all variables collected in the hn registry were included in the data base. all available information on ingested or administered solutes was recorded. linear mixed effects models were applied to conduct multivariable repeated measures analyses. following questions are to be answered in this study 1. is the baseline sodium level a predominant factor determining the rapidity of sodium increase? 2. ist he rapidity of sodium increase correlated to the given treatment? 3. can other predominant factors of slope of sodium increase be determined?

Eligibility criteria:
inclusion criteria: * patients with hypotonic hyponatremia \<130 mmol/l enrolled in the hyponatremia registry and classified as euvolemic hyponatremia, hypervolemic hyponatremia, hypovolemic hyponatremia or thiazide associated hyponatremia-group exclusion criteria: * patients, who could not be assigned to one etiology group

Keywords: hyponatremia
childhood chronic illness: an educational program for parents of children with on-going health care needs

Conditions: Chronic Illness

Summary: the long-term goal of this research is to strengthen parents' abilities to manage the complexities of childhood chronic illness. to achieve this goal, the team of parents, health care professionals, and researchers proposes the following specific aim: * develop, implement, and test a unique psycho-educational program, living with childhood chronic illness (the program), for effectiveness with parents of children who have chronic illnesses. the investigators propose the following hypotheses: at both 6 and 12 month follow-up points, parents taking part in the intervention, in contrast to control parents, will have: 1. greater perceived self-efficacy regarding their ability to manage the child's chronic condition; 2. greater parental ability to involve their child in shared management activities; 3. greater parental ability to cope at 6 and 12 months following the end of the intervention; 4. greater emotional health; and 5. greater parental perceived family quality of life.

parents will enroll in the study by contacting the study number: 206-987-1000 or by sending an email message to family.strengths@seattlechildrens.org. they will complete a survey taking no more than 60 minutes. parents will then be randomized to either take the class immediately or be in the control group which can take the class in 12 months. at the end of 6 and 12 months all the participants again take the survey. classes are 7 weeks in length, 2 hours each and are offered at various locations throughout the greater seattle area.

Eligibility criteria:
inclusion criteria: * child 2-11 years of age, with diagnosed chronic illness * parent at least 18 years of age, able to speak and read english at 4th grade level and able to attend a 7 week two-hour class program exclusion criteria: * child in active hospice treatment

Keywords: children chronic illness parent education parent support