Kornimate/medical-research-clean huggingface dataset:
vibration therapy in wheelchair basketball players

Conditions: Wheelchair Users; Athletic Performance; Disability; Disabled Persons

Summary: no study was found that investigated the effect of vibration therapy (vt) on recovery from exercise in wcb players. therefore, the aim of the study was to investigate the effects of wearable local vibration device on muscle soreness and athletic performance during recovery from exercise in the elbow area in wcb players.

vibration therapy (vt) has been widely used to increase performance and rehabilitate injuries in athletes. delayed onset muscle soreness (doms), caused by excessive overload after training and competitions, leads to loss of performance. the aim of this study was to investigate the effects of wearable local vt on muscle soreness and athletic performance in wheelchair basketball (wcb) players.

Eligibility criteria:
inclusion criteria: * being a wheelchair basketball players exclusion criteria: * having had an upper extremity operation within the last 6 months

Keywords: athlete disabled persons exercise pain proprioception upper extremity
influence of the covid-19 pandemic on stress and eating habits

Conditions: Nutrition

Summary: the coronavirus has caused containment of more than a third of the world's population. containment can drastically change lifestyle habits, including eating habits such as the number of meals, meal times or their composition. however, there is currently no data on the influence of confinement on eating habits.

this is an observational study by redcap questionnaire® via a flyer deposited in the waiting room of the covid screening centres. no incentive to complete the questionnaire will be made. the self-administered questionnaire will assess stress, changes in eating habits, and relationships with socio-demographic or lifestyle factors. this questionnaire includes 9 specific questions on nutrition and 40 general questions.

Eligibility criteria:
inclusion criteria: * all volunteers who are screened exclusion criteria: * none

Keywords: nutrition covid-19 eating habits stress
tdcs interventions for subthreshold depressive symptoms in young individuals.

Conditions: Subthreshold Depression; Young People; Transcranial Direct Current Stimulation

Summary: the purpose of this study is to assess the mechanisms of the effect of transcranial direct current stimulation (tdcs) in alleviating subthreshold depressive symptoms in young individuals, and individualized outcome prediction is carried out.

after being informed about the study and potential risks, all participants providing written informed consent will undergo screening to determine eligibility for study entry. on day 0, participants who meet the eligibility requirements will be randomized in a double-blind manner (participant and investigator) in a 1:1:1 ratio to receive tdcs targeting the left dorsolateral prefrontal cortex (ldlpfc), tdcs targeting the right ventrolateral prefrontal cortex (rvlpfc), or sham stimulation (10 sessions in 2 weeks). at baseline, after 2 weeks of stimulation, and at follow-up after 1 month and 3 months, participants will be assessed for brain network function, depressive symptoms, emotional status and social interactions.

Eligibility criteria:
inclusion criteria: * 1) be between the ages of 12-25; * 2) is right-handed on the edinburgh handedness inventory; * 3) 2-4 of the 9 depressive symptoms defined by the american diagnostic and statistical manual of diseases, fifth edition (dsm-5), lasting more than 1 week; or more than 5 depressive symptoms lasting more than 1 week but less than 2 weeks (i.e., not meeting criteria for a major depressive episode) (by dsm-5 clinical semi-definitive interview (k-sads-pl) (gilbody et al., 2017, jama); * 4) hamilton depression scale (hamd-24) 24 points≥ 8 points, \&lt; 24 points; * 5) gender is not limited; * 6) subjects and their families voluntarily participate and sign the informed consent form. exclusion criteria: * 1) individuals with the following diagnoses according to dsm-5: psychiatric disorders due to organic diseases, substance-related and addictive disorders, neurodevelopmental disorders, schizophrenia spectrum and other psychotic disorders, bipolar disorder (assessed by k-sads-pl); * 2) have two or more dsm-v-defined manic symptoms for 4 days but do not meet the criteria for hypomania or meet the dsm-v defined criteria for hypomanic symptoms for only 2-3 days; * 3) severe or unstable physical illness; * 4) have a moderate or higher risk of suicide (as assessed by the columbia suicide severity scale); * 5) received transcranial direct current stimulation in the past three months (continuous intervention time: \&gt;2 weeks); * 6) contraindications to transcranial direct current stimulation, such as brain implants, personal or family history of epilepsy; * 7) magnetic resonance scanning is contraindicated, such as in vivo metal implants.

Keywords: resting-state brain functional network social emotion
effect of a probiotic mixture on the gut microbiome and fatigue in patients with quiescent inflammatory bowel disease

Conditions: Inflammatory Bowel Diseases; Crohn Disease; Ulcerative Colitis

Summary: the study is proposed as a single-site randomized double-blind placebo-controlled trial requiring 4 study visits, where two of the visits are combined with their appointment for routine clinical care. the study population will consist of patients with quiescent cd and uc and ibd-unspecified recruited from the massachusetts general hospital crohn's and colitis center. all eligible subjects will have a confirmed diagnosis of cd, uc, or ibd-unspecified according to accepted clinical, endoscopic, radiologic, and histologic criteria. eligible patients will be contacted at the time of their routinely scheduled office visit and consented for the study. self-report and review of medical records will be used to obtain detailed information regarding their disease on an intake questionnaire completed by a research study coordinator. the study is proposed as a 12-week double-blind randomized controlled trial of the probiotic supplement compared to placebo. we propose to examine the effect of a specific probiotic supplement on the changes in the gut microbiome, serum metabolomic profile, and fatigue symptoms in patients with quiescent ibd. within 2 weeks of screening, eligible patients will be invited to visit mgh for a baseline visit. the patient will receive either the probiotic supplement or placebo for 4 weeks. the first follow up visit will be at week 4 to check for adverse events on study treatment, to check accountability of probiotics/placebo, and to complete the set of questionnaires. also, subjects will receive probiotic/placebo samples for the remaining 8 weeks of treatment. at week 8, subjects will receive a phone call from a study research coordinator to check in with probiotics/placebo intake for treatment compliance and accountability records, and to complete the set of questionnaires ascertaining subjective symptoms. last study visit will be at week 12 which is often combined with a regular office appointment. subject will provide serum blood and stool sample, as well as complete the set of questionnaires.


Eligibility criteria:
inclusion criteria: * age 18-75 years * confirmed cd or uc or ibd-unspecified diagnosed according to standard criteria * quiescent disease defined as harvey bradshaw index \< 4 at baseline (week 0) or sccai \< 2 * persistent ongoing fatigue symptoms * endoscopic or radiologic remission within 12 months of screening * washout of non-study probiotic supplements for at least 4 weeks prior to screening. exclusion criteria: * patients with clinical or endoscopically active inflammatory bowel disease * significant non-ibd comorbidity contributing to the fatigue (such as active cancer). * untreated severe depression or anxiety * known sleep disorders without adequate treatment, * presence of j-pouch or a stoma * ongoing use of other non-study probiotics * women who are pregnant or lactating

Keywords: microbiome fatigue probiotics
predictors of spinal anesthesia-induced hypotension in hypertensive patients

Conditions: Spinal Anesthesia-Induced Hypotension

Summary: this prospective observational study aims to evaluate predictive factors for spinal anesthesia-induced hypotension (sash) in hypertensive patients undergoing elective surgery. parameters such as internal jugular vein collapsibility index, carotid intima-media thickness, and flow-mediated dilation will be assessed using ultrasonography to determine their association with sash. demographic, anthropometric, and hemodynamic data will also be analyzed. the findings may improve perioperative management strategies for hypertensive patients receiving spinal anesthesia.

this study aims to investigate the relationship between carotid intima-media thickness (cimt) and spinal anesthesia-induced hypotension (sash) in hypertensive patients. sash is a common side effect of spinal anesthesia, with an incidence ranging from 15% to 33%, and is associated with significant clinical consequences such as increased morbidity and mortality. cimt is a well-established marker of atherosclerotic burden and cardiovascular risk. this study hypothesizes that cimt may be an independent predictor of sash in hypertensive patients. participants will undergo preoperative cimt measurements and standardized spinal anesthesia procedures, with hemodynamic variables and potential risk factors recorded for analysis.

Eligibility criteria:
inclusion criteria: adult hypertensive patients classified as asa ii-iii risk group. patients scheduled for elective surgeries requiring spinal anesthesia. exclusion criteria: presence of severe renal or hepatic failure, or severe respiratory or cardiovascular diseases. contraindication to spinal anesthesia. failure of spinal anesthesia. history of carotid surgery or presence of carotid plaques. presence of anxiety.

Keywords: spinal anesthesia hypotension hypertensive patients hemodynamic predictors
the resilient minds program in fire departments

Conditions: Trauma; Critical Incident; Mental Illness

Summary: the purpose of the study is to assess the impact of a mental health training program in volunteer and career firefighters.

the problem: firefighters are frequently exposed to distressing events, or critical incidents such as motor vehicle accidents, burnt bodies, failed rescue attempts, threats to one's own life, and completed suicides that can trigger posttraumatic stress reactions. previous research show that first responders and other public safety personnel report frequent exposure to traumatic events and are at increased risk for mental health illnesses. the study objective: to assess the impact of a mental health training program in volunteer and career firefighters. the study sample: 600 firefighters: 300 prince edward island volunteer or career firefighters, 300 vancouver career firefighters intervention: vancouver fire \& rescue services and the canadian mental health association-vancouver fraser co-developed a new program called, "resilient minds-building the psychological health of fire fighters." the resilient minds training will educate firefighters about the effects of trauma, how to recognize signs of mental health illness and how to access support after critical events. it also trains firefighters to recognize mental health and addictions in co-workers and how to facilitate their help-seeking. outcomes: the impact of the program will be assessed by pre- and post-program surveys, 3-month, 6-month, 12-month follow-up surveys.

Eligibility criteria:
inclusion criteria: * 18 years and older * can read, understand, speak english * career or volunteer firefighters in pei participating in resilient minds program

Keywords: firefighters mental resiliency peer support
the triglyceride/glucose index and sglt-2 inhibitors

Conditions: Metabolic Disease; Diabetes

Summary: this study was designed to evaluate the change in triglyceride glucose index, one of the atherosclerotic markers, in patients with type 2 dm followed in the internal medicine clinic of samsun university, samsun training, and research hospital. methods: the data of the patients who were followed up for at least 3 months by making a retrospective file review will be recorded and analyzed. it is planned to start the study following the ethics committee's approval.

the data of all patients who applied to samsun training and research hospital internal medicine outpatient clinic for 12 months in 2022 and were started on sglt-2 inhibitor will be examined. according to the inclusion and exclusion criteria stated below, the patients will be evaluated and the data of the patients admitted to the study will be analyzed. the triglyceride glucose index of the patients before starting the sglt-2 injection and the trig/glucose index at the end of 3 months of treatment will be calculated by the researchers using the data in the system. no additional blood tests or laboratory analyses will be performed on the patients. triglyceride, glucose, and glycosylated hemoglobin values were checked at the beginning of the treatment and at the 3rd-month follow-up.

Eligibility criteria:
inclusion criteria: * type 2 dm * age \>18 years old * dapagliflozin 10 mg or empagliflozin 10 mg or 25 mg * 3 months follow-up period exclusion criteria: * type 1 diabetes * gestational diabetes * age \< 18 years old * insufficient or missed laboratory test results * medical treatment for dyslipidemia * hypothyroidism

Keywords: sglt-2 inhibitor triglyceride index
awareness & use of emergency contraception

Conditions: Emergency Contraception

Summary: general objective: to decrease the percentage of unwanted and/or unplanned pregnancies and their consequences on women's reproductive health. specific objectives: 1. to assess awareness of the study participants about emergency contraception. 2. determine the percentage of ever use among the participants. 3. to identify factors that affect the awareness and use of emergency contraception among the study participants


Eligibility criteria:
inclusion criteria: * married women in reproductive age (15 - 49 years) exclusion criteria: * infertile and postmenopausal women.
descriptive analysis of clinical outcomes in patients with prostate gland cancer, which spreads to other parts of the body, who were treated first with novel anti-hormone therapy followed by a second line treatment with novel anti-hormone therapy or radium-223 (xofigo).

Conditions: Metastatic Castration-resistant Prostate Cancer (mCRPC)

Summary: in this study researcher want to learn more about the overall survival in patients suffering from prostate gland cancer which spread outside the prostate to other parts of the body who received either a novel anti-hormone therapy (nah) or radium-223 (xofigo) after a prior nah therapy (first line treatment). additionally the researchers are also interested in the occurrence of bone fractures and other skeletal events. basis for this study will be the us based flatiron database which provides access to clinical data for cancer patients.


Eligibility criteria:
inclusion criteria: * patients with documented mcrpc receiving 1l nahs. * initiation of ra-223 after 1l nah therapy, or * initiation of sequential nah therapy after 1l nah therapy exclusion criteria: * patients involved in clinical trials * patients who received combined therapies in 1l or 2l
influence of acupuncture on emotional measures and quality of sleep among schizophrenia patients

Conditions: Schizophrenia; Schizoaffective

Summary: insomnia, a common feature of schizophrenia, has serious consequences for daytime functioning and quality of life. although insomnia is most often treated with medication, a growing number of studies have demonstrated the efficiency of a variety of relaxation techniques, cognitive behavioral therapies and alternative medicine procedures. acupuncture is among the oldest healing practices in the world. part of traditional chinese medicine, acupuncture aims to restore and maintain health through the stimulation of specific points on the body. previous studies have demonstrated that acupuncture has a positive influence on a number of diseases and disorders, among them depression, chronic pain and sleep disorders. hence, the aim of the present study is to examine the effects of acupuncture as a treatment for insomnia in schizophrenic patients.the study begins with a 7-day, running-in, no-treatment period, followes by an 8-week experimental period. during the experimental period, subjects receive acupuncture treatments twice a week. during the first week of the study (no-treatment period) and the last week of the experimental period, subjects' sleep is monitored with a wrist actigraph, and subjects complete a wide spectrum of questionnaires.


Eligibility criteria:
inclusion criteria: 1. schizophrenia or schizoaffective disorder - diagnosed according dsm-4. 2. capability to sign inform consent. exclusion criteria: 1. unstable physical illness 2. drug or alchohol abuse or dependence

Keywords: acupuncture schizophrenia insomnia
a study of azidothymidine (azt) in the treatment of hiv infection in patients receiving a bone marrow transplant

Conditions: Lymphoma, Non-Hodgkin; HIV Infections

Summary: to determine whether zidovudine (azt) in conjunction with bone marrow transplantation prevents the reinfection of donor hematopoietic/lymphoid cells in patients with positive htlv iii antibody and large cell/diffuse histiocytic lymphoma. patients who are candidates will be evaluated for htlv iii activity and drug levels.


Eligibility criteria:
exclusion criteria co-existing condition: patients with current life-threatening infection at time of transplant that would preclude a transplant are excluded. concurrent medication: excluded: * other anti-retroviral agents. patients with current life-threatening infection at time of transplant that would preclude a transplant are excluded. patients must be: * htlv iii antibody positive by elisa or western blot or htlv iii viremia. * at high mortal risk with a diagnosis of aids or aids related complex (arc). * also patient must fall into one of the following categories: * have an hiv seronegative identical twin to serve as a bone marrow donor. * have documentation of large cell/diffuse histiocytic lymphoma/dpdl. * be a good risk candidate for bone marrow transplant.

Keywords: lymphoma, large-cell acquired immunodeficiency syndrome aids-related complex zidovudine bone marrow transplantation
renoprotective effect of febuxostat on contrast induced acute kidney injury in chronic kidney disease patients stage 3

Conditions: Chronic Kidney Disease stage3; Contrast-induced Nephropathy

Summary: this study will determine the renoprotective effect of febuxostat in prevention of contrast induced acute kidney injury in chronic kidney disease patients stage 3 undergoing percutaneous coronary intervention.

in this randomised non blinded clinical trial, investigators will study 120 ckd patients undergoing pci to determine the renoprotective effect of febuxostat in prevention of contrast induced acute kidney injury . so, the patients will be divided into two arms based on block randomization. each arm compromise 60 patients. the first arm will receive iv hydration and n-acetylcysteine (ctrl arm) . the second arm will receive iv hydration, n-acetylcysteine and febuxostat (f arm). block randomization will be used in this clinical trial design to reduce bias and achieve balance in the allocation of participants to treatment arms.

Eligibility criteria:
inclusion criteria: age ≥ 18 years old . patients under treatment of high dose statin(atorvastatin (40-80 mg/day) . glomerular filtration rate=30-59ml/min. undergoing coronary pci. exclusion criteria: patients under treatment with febuxostat. known allergy to febuxostat. high osmolar contrast media during the procedure .
myofunctional therapy in patients with mild-moderate sleep apnea

Conditions: Obstructive Sleep Apnea of Adult; Myofunctional Therapy

Summary: the main objective of this study is to compare the change in the apnea-hypopnea index (ahi) in patients with mild to moderate sleep apnea without daytime sleepiness after 12 months of myofunctional therapy exercises with respect to the placebo group (the placebo group will be instructed in simulation exercises that do not alter the function or morphology of the upper airway)

background: alternative treatment therapies to positive upper airway pressure (cpap) for obstructive sleep apnea syndrome (osas) have been developed in recent years. myofunctional orofacial therapy (mft) is one of these alternatives and consists of exercises that improve mobility and increase muscle strength of the orofacial structures that contribute to the etiopathogenesis of osas. to date, any study to treat sleep apnea patients under this therapy has been conducted in spain. moreover, its long-term effect has not been evaluated worldwide. main objective: to compare the reduction in the apnea-hypopnea index (ahi) in patients with mild to moderate sleep apnea without daytime sleepiness after 12 months of myofunctional therapy exercises with respect to the placebo group (the placebo group will be instructed in simulation exercises that do not alter the function or morphology of the upper airway) methodology: a 12-month, randomized, parallel-group, clinical trial will be conducted. patients with an ahi ≥ 5 events per hour assessed by a respiratory polygraphy (rp) will be randomized to a mft treatment branch or to another placebo exercises branch. a speech therapist will instruct patients to perform the exercises in both groups for three months. at the end of this period, a rp will be performed on both groups and the same treatment that they were doing will be maintained at home. one year later, a new rp will be performed and changes in ahi, oximetry parameters and snoring will be compared in both groups, as well as sleepiness, quality of life and the degree of adherence to the treatment.

Eligibility criteria:
inclusion criteria: * patients over 18 and under 80 years old. * patients with apnea-hypopnea index from 5 to 29 assessed by a respiratory polygraphy. * absence of daytime sleepiness (epworth sleepiness scale \<12). exclusion criteria: * refractory high blood pressure (blood pressure that is not controlled with three antihypertensive drugs, including a diuretic). * ictus, transient ischemic attack, neuromuscular diseases, acute coronary syndrome or hospitalization for worsening heart failure, in the previous 30 days. * professional drivers, profession of risk or respiratory failure. * previous surgical intervention for the treatment of sleep apnea (those patients who have refused treatment with cpap or mandibular advancement devices after 1 month of not using them,could be included).