Kornimate/medical-research-clean huggingface dataset:
the effects of marijuana on orientation and motor coordination and brain metabolism in regular smokers of marijuana

Conditions: Marijuana Dependence

Summary: this study investigates the effects of 17mg and 13mg delta thc on orientation and motor coordination and brain metabolic activity in regular users of marijuana. subjects were tested twice, after smoking cigarettes with marijuana and after smoking cigarettes without marijuana.on both occasions they performed on a virtual reality maze task. they were afterwards scanned in positron emission tomography (pet) with fluoro-deoxy-glucose (fdg).

this study investigates the effects of 17mg and 13mg delta thc on orientation and motor coordination and brain metabolic activity in regular users of marijuana. subjects were tested twice, after smoking cigarettes with marijuana and after smoking cigarettes without marijuana. on both occasions they performed on a virtual reality maze task. they were afterwards scanned in positron emission tomography (pet) with fluoro-deoxy-glucose (fdg). 12 subjects were tested so far on both conditions.

Eligibility criteria:
inclusion criteria: * marijuana dependence * age 20-65 * male and female exclusion criteria: * pregnant women * dependence on other substances * psychiatric diagnosis apart from marijuana dependence * neurological disorder * young persons

Keywords: marijuana, fdg, pet, maze, thc, motor coordination.
dual boosted protease inhibitor regimens without any additional antiretroviral therapy in hiv-1 infected patients (anrs127)

Conditions: HIV Infections

Summary: the purpose of this study is to evaluate virological efficacy and safety of two double protease inhibitor regimens: atazanavir/fosamprenavir/ritonavir 300 mg once daily/ 700/100 mg twice daily, versus atazanavir/saquinavir/ritonavir 300/1500/100 mg once daily in protease inhibitor naive hiv-1 patients.

the purpose of this randomized, open-label study is to evaluate virological efficacy and safety of two double protease inhibitor regimens: atazanavir/fosamprenavir/ritonavir 300 mg once daily/ 700/100 mg twice daily, versus atazanavir/saquinavir/ritonavir 300/1500/100 mg once daily in protease inhibitor naive hiv-1 patients. patients with cd4 cell counts over or equal to 200/mm3, hiv viral load between 10,000 and 750,000 copies per milliliter, and wild-type genotype at baseline will be eligible. this multicenter study will enroll 60 patients (n=30 in each group). the planned duration of the study is 48 weeks from the enrolment of the last subject. the primary efficacy endpoint will be virologic success defined as hiv rna levels below 50 copies/ml after 16 weeks of initial treatment. the durability of this response will be evaluated and patients will be followed for 48 weeks. the primary safety endpoint will be treatment interruptions because of adverse effects.

Eligibility criteria:
inclusion criteria: * protease inhibitor naive patients * wild type genotype * cd4 greater than 200/mm3 * viral load between 10,000 copies/ml and 750,000 copies/ml * signed informed consent exclusion criteria: * pregnancy; breast feeding * antiretroviral (arv) pretreated patients * hyperlipidemic treatment * evolutive disease

Keywords: hiv protease inhibitors hiv infections atazanavir saquinavir fosamprenavir ritonavir treatment naive
evaluation of improved onboard patient imaging

Conditions: Head and Neck Cancer; Breast Cancer; Upper Gastrointestinal Cancer; Lung Cancer; Pelvic Cancer

Summary: the primary objective of radiation therapy is to deliver a therapeutic dose of radiation precisely to the target while minimizing exposure to healthy surrounding tissues. image-guided radiation therapy (igrt) involves acquiring cone beam computed tomography (cbct) scans just before or during treatment sessions. by comparing the cbct images with the reference images from the treatment planning process, clinicians can make necessary adjustments to ensure precise targeting and account for any changes that may have occurred since the initial planning. conventional cbct technology is, however, limited by several factors including long acquisition times that result in motion artifacts in the image, smaller fields of view that limit the volume of anatomy that can be imaged, poor image quality that limits soft tissue visibility, and artifacts created by dense metal implants. this study will evaluate a novel cbct imaging solution ("hypersight") that has the potential to address the challenges of conventional cbct.


Eligibility criteria:
inclusion criteria: 1. patient is willing and able to provide written consent. 2. patient is at least 18 years of age at the time of consent. 3. patient has biopsy confirmed malignancy and recommendation for definitive or palliative radiation to the head and neck, breast, lungs, upper gi structures, or pelvis. 4. patient has ecog performance status 0-2. 5. patient will be receiving radiation therapy at university of maryland medical center, department of radiation oncology. exclusion criteria: 1. patient is pregnant or attempting pregnancy. 2. patient has implanted cardiac devices or nerve stimulation devices. 3. patient has known genetic pre-disposition for sensitivity to radiation (e.g., li fraumeni). 4. patient receives palliative radiation for 5 or fewer fractions. 5. patient is part of a vulnerable population (per iso 14155:2020, "individuals who are unable to fully understand all aspects of the investigation that are relevant to the decision to participate, or who could be manipulated or unduly influenced as a result of a compromised position, expectation of benefits or fear of retaliatory response"). this includes prisoners.

Keywords: cbct
contamination free bacterial swap

Conditions: Sinusitis

Summary: a test of a newly designed device (contamination free bacterial swab). this device can be used to introduce a standard bacterial swab into the nose without direct or indirect contact with the nasal vestibule.

aim: the investigators want to improved the current method for bacterial culture test in patients with possible sinusitis by reducing the risk of contamination from the nasal vestibule. the investigators will examine whether significantly fewer staphylococcus aureus are detected in the middle meatus when applying a new device for bacterial swab introduction. this device is designed to prevent bacterial pollution from the nasal vestibule. more precisely, the investigators hope to reduce the frequency of staphylococcus aureus in nasal swabs from 10-15 % to 0-5 %. the overall objective is to avoid over-treatment with broad-spectrum antibiotics in patients with sino-nasal disease. design: a comparative study in which patients serve as their own control. a bacterial swab will be introduced to both sides of the nose; on the right side using the new device, on the left side using the present day technique (visual guidance). 70 participants will be included. statistics: a chi-square test will be used for comparison of frequencies.

Eligibility criteria:
inclusion criteria: * symptoms of upper airway disease exclusion criteria: * mental illness * need for interpreter

Keywords: acute rhinosinusitis staphylococcus aureus nasal vestibule contamination
this study is to evaluate whether receiving education and glucose monitoring with the cgm device will improve patient-reported outcomes by improving patient's satisfaction and quality of life (qol) with glucose monitoring device.

Conditions: Diabetes Mellitus

Summary: the purpose of the study is to improve patient-reported outcomes by improving patient's satisfaction and quality of life (qol) with glucose monitoring device through pre and post satisfaction survey of patient with diabetes.


Eligibility criteria:
inclusion criteria: * aged 18 or older * diagnosed with type 1 or type 2 diabetes who are on insulin * able to speak and understand english language * scheduled to receive a standard inpatient diabetes education consultation * must not have used cgm in the six months prior to admission * owns a smartphone * demonstrates the ability to follow instructions and be capable of providing informed consent to participate in the program exclusion criteria: * those who are known to be pregnant. this is due to complexity of pregnancy-related changes in glucose metabolism and increased skin sensitivity, or changes in skin condition to adhesives and materials used in cgm devices. * non-english speakers. as this is small study to evaluate which method is favorable using a survey only validated in english, enrolling non-english speakers would require additional resources/translations/personnel for evaluation and the education intervention that are not logistically possible right now.
examination of edema after arthroscopic shoulder surgery

Conditions: Edema; Arthroscopy; Shoulder

Summary: the investigators's aim is to examine trunk and upper extremity edema after arthroscopic rotator cuff repair and/or labrum repair surgeries. during surgery, the shoulder joint capsule is cut and the joint is entered arthroscopically. during this procedure, approximately 3-6 liters of saline fluid is injected into the joint, depending on the duration of the surgery. the given fluid accumulates out of the joint in relation to the duration of the surgery and the amount of fluid given. in this study, the investigators aim is to examine how much the extra-articular fluid collects under the skin of the upper extremity and trunk, and the change in the amount of fluid 24 hours after surgery. examination of the amount of subcutaneous fluid may help to better understand the postoperative complications such as edema, carpal tunnel syndrome, compartment syndrome, myolysis, and dyspnea. how much edema the joint and surrounding structures are exposed to and its relationship with the duration of surgery can help to clinicians determine the safe discharge time.


Eligibility criteria:
inclusion criteria: * arthroscopic shoulder surgery planned * 18-65 years old exclusion criteria: * frozen/stiff shoulder * metabolic and endocrine diseases * dermatological pathologies * hyperlaxity

Keywords: edema shoulder arthroscopy
telerehabilitation versus supervised pilates training in lipedema women

Conditions: Lipedema

Summary: 1. pilates exercise: the pilates method is a low-intensity form of movement based on body control, which works the body in a complete way, promoting physical and mental health. pet is different when compared to traditional exercises, which, in turn, tend to isolate the working muscles and have specific training approaches using repetitive motions. 2. telerehabilitation: telehealth is emerging as a key method for delivering essential healthcare. primary care research suggests that telehealth is acceptable and has potential to overcome geographical barriers for individuals needing many times rehabilitation by eliminating the need for extensive and costly travel 3. diet approach: a customized low-carbohydrate high-fat (lchf) restricted caloric diet in women with lipedema will be used for 12 weeks. the lchf diet may be a valuable nutritional strategy for lipedema and overweight/obese women, reducing inflammatory status with a beneficial effect on weight, glucose profile the concentration of triglycerides and hdl


Eligibility criteria:
inclusion criteria: 1. sixty female patients diagnosed with lipedema. 2. their ages will range from 35-45 years old. 3. patients diagnosed with lipedema ≥ 5 years. 4. patients with grade 2 and 3 lipedema. 5. patients with type 2 and 3 lipedema. 6. patients with bmi ≥ 25 kg/m2 7. all patients will be clinically stable. exclusion criteria: patient with any of the following will be excluded from the study: 1. patients with lower limb edematous diseases such as lymphedema or chronic venous insufficiency. 2. patients with history of previous liposuction. 3. patients with asymmetrical lower limbs. 4. patients with history of bariatric surgeries. 5. patients on weight loss medications. 6. patients any medical condition prohibiting exercise (cardiac pacemakers, diabetes mellitus, uncontrolled hypertension, and congestive heart failure) 7. pregnant females. 8. patients with bmi ≥ 40 kg/m2 (morbid obese). 9. cancer patients (patients on chemotherapy, immunotherapy radiopathy). 10. infectious diseases (hiv/aids, hcv, and tuberculosis). 11. chronic inflammatory autoimmune disease such as sjogren's syndrome 12. patients with neurological disorders: stroke and epilepsy.
study to asses pharmacodynamics, pharmacokinetics, safety and tolerability of azd0328 in patients with schizophrenia

Conditions: Schizophrenia

Summary: this study is to assess the pharmacodynamics, pharmacokinetics, safety and tolerability of multiple ascending doses of azd0328 in patients with schizophrenia


Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia according to the dsm-iv (diagnostic and statistical manual of mental disorders, 4th edition) * low level of extra-pyramidal symptoms * no clinically significant findings on physical examination exclusion criteria: * diagnosis of schizoaffective or schizophreniform disorders * any significant psychiatric or neurological disease other than schizophrenia
biopsy collection and repository database

Conditions: Cardiovascular Diseases

Summary: use samples procured from patients to improve understanding of molecular, cellular, and tissue-level processes produced by a variety of cardiac diseases and therapeutic interventions.

this is a prospective study enrolling patients referred for or undergoing cardiovascular procedures or treatment at the university of kentucky. the study aims to facilitate the discovery of novel diagnostic biomarkers and therapeutic targets and improve the pathophysiological understanding of cardiac conditions.

Eligibility criteria:
inclusion criteria: * all patients undergoing evaluation of a cardiac condition or receiving a right heart catheterization with biopsy clinically indicated who are at least 18 years of age. exclusion criteria: * patients without a cardiovascular or amyloidosis diagnosis, under 18 years of age.
pathogenic microorganisms in adult severe pneumonia patients

Conditions: Pathogenic Microorganism of Serious Pneumonia

Summary: this study aimed to evaluate pathogenic microorganisms in adult severe pneumonia patients in different cities of liaoning province

the pathogenic microorganisms of adult patients with severe pneumonia is detected in this study. clinical treatment does not involve , so it meets the ethical requirements. the clinical data, laboratory test results and imaging data of adult severe pneumonia patients in different hospitals in different cities are recorded. the pathogenic microorganism is detected by second-generation sequencing of lower respiratory tract sputum or alveolar lavage fluid samples, and the data were sorted out to draw the pathogenic microorganism spectrum of adult severe pneumonia in liaoning area. it will be used to guide clinical empirical treatment.

Eligibility criteria:
inclusion criteria: * meet the standard of severe pneumonia： main standards： requiring mechanical ventilation or septic shock requiring vasoconstrictor therapy. secondary standards：(only if 3 items are met) disturbance of consciousness; respiratory rate ≥ 30 times/min; pao2/fio2 ≤ 250, or pao2 \< 60mmhg; azotemia (bun ≥ 7.12mmol / l); hypotension requires strong fluid resuscitation; infiltration of multiple lobes; leucopenia (wbc \< 4 × 109 / l); thrombocytopenia (\< 10 × 109 / l); hypothermia (t \< 36 ℃). exclusion criteria: * refuse to sign informed consent; inaccurate results due to unqualified sputum or balf samples
ivermectin treatment of persons with onchocerciasis-associated epilepsy

Conditions: Epilepsy

Summary: randomized clinical trial in the logo health zone, in ituri province, democratic republic of congo to compare seizure freedom in onchocerciasis infested epilepsy patients who ivermectin treatment once a year compared to 2 and 3 times a year. all participants also receive anti-epileptic drugs according to local guidelines for epilepsy treatment. participants will be followed for 12 months. the primary endpoint is seizure freedom defined as no seizures during the last fourth months of the trial.

randomized clinical trial in the logo health zone, in ituri province, democratic republic of congo to compare seizure freedom in onchocerciasis infested epilepsy patients who ivermectin treatment once a year compared to 2 and 3 times a year. all participants also receive anti-epileptic drugs according to local guidelines for epilepsy treatment. participants will be followed for 12 months.the primary endpoint is seizure freedom defined as no seizures during the last fourth months of the trial.

Eligibility criteria:
inclusion criteria: * age 5 years and above * signed informed consent form * normal neurological development until onset of epilepsy * onset of epilepsy between ages of 5 and 18 years * presence of microfilaria in skin snip and/or antibodies against ov16 exclusion criteria: * ivermectin intake the last 9 months * pregnancy or breastfeeding * known or suspected allergy to ivermectin * loa loa microfilariae in blood * epilepsy with known cause (e.g. severe head trauma, perinatal asphyxia, patients with a history of cerebral malaria, meningitis or encephalitis) * concomitant acute illness or chronic medication use * chronic alcohol/substance use
effect of ph and fluoride concentration of dentifrices on caries control

Conditions: Dental Fluorosis; Dental Caries

Summary: this study aims to assess the overall effect of ph and fluoride concentration of liquid dentifrices in the control of children dental caries of a fluoridated area, through visual inspection and the quantitative light-induced fluorescence (qlf) method. toenail f concentration of a subsample of the children enrolled will be evaluated, in order to assess f bioavailability from these formulations and the evaluation of the concentration of fluoride incorporated into the biofilm will be done 6 months after initiation of the dentifrices use.

dentifrices have been recognized as one of the contributors in the increased prevalence of dental fluorosis, due to the fact that children in early childhood usually eat lots of them during brushing. as an alternative to the reduction of fluorosis have been suggested to reduce the concentration of fluoride toothpaste, however, its efficacy is not well established, increasing when the ph of the toothpaste is acidic, with a greater diffusion of f in the enamel. therefore, this study aims to assess the overall effect of ph and fluoride concentration of liquid dentifrices in the control of children dental caries of a fluoridated area. a randomized double-blind study will be conducted with approximately 360 children aged 2 to 4 years old at public daycare centers located in a fluoridated area. children will be examined by two examiners and classified according to caries activity. for 12 months, children will use 3 times a day, one of the toothpaste to be tested, with different concentrations of fluoride and ph. at the end of this period, children will be examined by the same examiners to check the progression of lesions. clinical examinations should be performed by 2 calibrated examiners (kappa 0.8) at baseline and after 12 months. the diagnostic criteria of caries activity (active, inactive) and integrity of the surface of the lesion will be used. there will be a quantitative assessment of carious lesions fluorescence with a portable qlf equipment. in half of the sample, nails and plaque will be collected 6 months after initiation of the dentifrices use. samples of plaque will be analyzed for fluoride using an ion-specific electrode after diffusion with hexamethyldisiloxane-facilitated disiloxane (hmds). the presence of nails f will be analyzed as described above. for statistical analysis will be used anova and test for individual comparisons.

Eligibility criteria:
inclusion criteria: * \>= 2 years and \<= 4 years * not having participated in any other clinical study within 3 months prior to selection; * not having very large carious lesions or dentin sensitivity during the study (if this occurs, the child will be referred for treatment); * signature of informed consent by the parents exclusion criteria: * using orthodontic appliances

Keywords: dentifrices fluoride nails plaque
sacramento clinical high risk for psychosis stepped-care program

Conditions: Clinical High Risk for Psychosis; Ultra High Risk for Psychosis

Summary: this is a dissemination and implementation study that is evaluating a stepped-care intervention for identifying and treating youths at clinical high-risk for psychosis within multiple community mental health centers.

the study aims to increase the capacity to identify and treat youths at clinical high-risk for psychosis (chrp) across sacramento, ca by disseminating and implementing in community mental health clinics (cmhcs) universal screening and a stepped-care, team-based intervention that includes training and ongoing support in a cognitive behavioral therapy package called cognitive behavioral case management (cbcm). the study is being conducted in nine non-psychosis specialty cmhcs across 5 agencies, all of which treat young people with public insurance (medi-cal/medicaid) or no insurance. all youths aged 12-25 will be screened when beginning care and those who screen positive and agree will be assessed by the only specialty early psychosis clinic in the county, at the university of california-davis. thus the study also aims to triage this limited resource of specialized early psychosis expertise. chrp+ youth will then begin a 2 year stepped-care intervention at their cmhcs and can move to the early psychosis specialty clinic if they still meet chrp criteria after 2 years or develop psychosis. the specialty early psychosis service provides ongoing support and consultation.

Eligibility criteria:
inclusion criteria: 1. clinical high risk for psychosis syndrome as assessed by the mini-sips 2. aged between 12-25 years old 3. receiving care in one of six identified community mental health clinics 4. eligibility for sacramento county medicare 5. ability to provide informed consent exclusion criteria: 1. intellectual disability (iq\&lt;70) 2. urgent clinical need for a higher level of care

Keywords: psychosis stepped-care psychosis screening community-based care dissemination and implementation
virtual reality versus mirror therapy on balance and muscle strength in children with hemiplegic cerebral palsy

Conditions: Rehabilitation

Summary: previous research has demonstrated balance deficits ranging from 28%-43% depending on the nature of the balance task in individuals with cp compared to controls (kenis-coskun et al., 2016). as balance is critical for underlying normal movement, improvements in static and dynamic balance are important goals in rehabilitation for ambulatory children with cp (saether et al., 2013). balance deficits are among the symptoms that having a more profound impact on motor function and quality of life inn with cp children (lai et al., 2017). poor balance reduces the ability to perform gait-related activities and increases the risk of falling, which, in turn, limits participation in daily activities, including sports and physical activities (usuba et al., 2015).


Eligibility criteria:
inclusion criteria: * their ages will range from 6 to 10 years old. * the degree of spasticity will range from 1+ to 2 grades according to modified ashworth scale (numano and günel, 2011) (appendix ii). * they will be on level i and ii on gross motor function classification system (gmfcs) (palisano et al., 2008) (appendix iii). * their heights will be one meter or more. * they will be able to follow the verbal commands or instructions. exclusion criteria: * severe visual or auditory problems. * epilepsy. * history of surgical interference in lower limbs. * botulinum toxin injections of the lower limbs during the previous six