Kornimate/medical-research-clean huggingface dataset:
association between household health behaviors and asthma in children

Conditions: Asthma in Children

Summary: this study plan to study the association between household health behavior (cleaning habits) and children's asthma. in addition, reconfirm the health effects of indoor environmental exposure to phthalates plasticizers, mite, fungi, and bacteria, and cockroaches on children's asthma. thus, the investigators can provide a non-pharmacological intervention to reduce the disease burden of children's asthma and allergic diseases.

the investigators plan to invite 80 children, aged 7-12 years-old who have physician-diagnosed asthma, and another age- and gender-matched children without asthma to join our study. first, obtaining clinical data of disease status, and ask participants to fill out questionnaires after recruiting. second, participants have to record body temperature, peak expiratory flow, heart rate, finger o2 saturation percentage, asthma attack frequency continuously by care-giver every day. third, the investigators will perform indoor environmental assessments in the subject's house, including indoor air quality, dust samples, culture for fungi and bacteria, and cockroaches. the investigators will also count the dust mites and measure phthalates concentration in every dust sample. then, health behavior intervention for one month will be provided to every participant. the investigators will teach children's guardians (care-giver) how to change the health behaviors to clean indoor environment, including the health behaviors in bedroom, kitchen room, restroom, refrigerator, washing machine, and incense burning hall. after 1 months, the investigators will investigate whether changing health behavior affects the exposure of phthalates, dust mites, fungi, bacteria, and cockroaches, and evaluate the effects of health behavior intervention on the clinical status of children's asthma. children's asthma severity assessment will be recorded by act and also by symptomatology every day. household health behaviors (cleaning habits) questionnaires also will be completed per week and continuously for 4 weeks.

Eligibility criteria:
inclusion criteria: * aged 7-12 years-old who have physician-diagnosed asthma * stable patient exclusion criteria: * acute allergies * severe brain and heart disease * mental illness
the effect of cold exposure on glucose tolerance

Conditions: Hyperglycemia

Summary: the purpose of the study is to evaluate the effect of cold exposure on an individual's glucose tolerance. previous research has already shown that 10 days acclimation to a mild cold environment (14-15°c) can enhance insulin sensitivity. however, the duration in the cold environment was 6 hours per day which may not be practical for everyone. therefore, the present study will investigate the effect of a shorter, and more intense cold exposure on an individual's glucose tolerance. it is hypothesised that cold exposure before consuming a glucose drink will enhance glucose clearance.


Eligibility criteria:
inclusion criteria of healthy population: * signed informed consent. * white european. * male. * age 18 - 40 years at the start of the study. * bmi ≥ 20 and \< 30 kg/m2. exclusion criteria of healthy population: * smoking. * active diseases (cardiovascular, diabetes mellitus, liver, kidney, cancer or other). * cold-acclimated (takes daily cold baths, works in a refrigerated environment, or regular cold water swimmer). * unstable body weight (gain or loss \> 5kg in last 3 months). * currently undertaking a diet. inclusion criteria of prediabetes population: * signed informed consent. * white european. * male or female. * women should be postmenopausal or use hormonal contraceptives. * age 30 - 75 years at the start of the study. * bmi ≥ 25 and \< 35 kg/m2. * generally healthy, no medication use that interferes with metabolism. if volunteers need medication (e.g. statin drugs, nsaids), it will be reviewed with the dependent physician on an individual basis. * impaired fasting glucose (5.6 mm to 6.9 mm) and/or blood glucose values 7.8-11.0 mm 2h after glucose drink consumption during ogtt in screening. exclusion criteria of prediabetes population: * smoking. * active diseases (cardiovascular, diabetes mellitus, liver, kidney, cancer or other). * cold-acclimated (takes daily cold baths, works in a refrigerated environment, or regular cold water swimmer). * unstable body weight (gain or loss \> 5kg in last 3 months). * currently undertaking a diet.

Keywords: cold exposure glucose tolerance
"score infectivity" during reoperation on total hip or knee prosthesis

Conditions: Osteoarthritis

Summary: the hip or knee is a validated treatment of end-stage osteoarthritis, and these interventions commonly make a significant improvement in the quality of life of patients. infection can occur in 1-5% of cases. diagnosis is often difficult, but the knowledge of infected or not infected character directly influences the surgical conduct. it is therefore recommended that the positive or negative diagnosis is made in the most reliable way possible, but no single element only allows a low diagnosis. the concomitant use of several clinical, radiological and aggregated into a composite score history could help facilitate this preoperative approach during reoperation on prosthetic joint


Eligibility criteria:
inclusion criteria: * patients over 18 years * patients operated in the service in 2014 to care for end-stage hip or knee osteoarthritis by implantation of a total hip or knee prosthesis. exclusion criteria: * patients under 18 years

Keywords: knee knee osteoarthritis knee replacement hip hip osteoarthritis hip replacement
high protein diet and atherosclerosis

Conditions: Atherosclerosis

Summary: atherosclerosis is the underlying cause of the majority of cardiovascular diseases, including myocardial infarction and strokes, and results in tremendous morbidity and mortality. a western-type diet is a major risk factor for atherosclerosis because of the high saturated fat, cholesterol, and refined carbohydrate contents. dietary strategies to reduce cardiovascular disease burden therefore focus on restriction of saturated fat, cholesterol, and refined carbohydrates whereas "lean" protein intake is recommended and has become popular. however, results from studies conducted in animal models suggest high dietary protein intake is also atherogenic. the investigators' extensive preliminary data in animal models show that dietary protein increases atherosclerotic plaque formation and size and promotes necrotic core formation, a characteristic of rupture-prone plaques. the goal of the current proposal is to provide deeper insights into the relationship between protein intake and the pathogenesis of atherosclerosis by studying the mechanisms involved in protein-mediated atherogenesis and formation of necrotic plaques. the overarching hypothesis is that high protein intake drives atherosclerosis via leucine-mediated mtorc1 signaling in macrophages, which inhibits macrophage mitophagy and aggrephagy and stimulates macrophage proliferation. furthermore, the investigators hypothesize that proteins from animal sources are more atherogenic than proteins from plant sources, because animal proteins contain more leucine than plant proteins. the investigators will test these hypotheses by using a sophisticated array of experimental strategies, including assays in primary macrophages and human monocyte-derived macrophages and genetically engineered mouse models. in addition, they will begin to translate the results obtained in vitro and in animals to people, and explore approaches to pharmacologically target the pro-atherogenic pathways as novel cardiovascular therapeutics. this proposal represents a paradigm shift in how a western-type diet affects vascular health which has important implications since many adults in western societies consume excess protein and dietary protein is heavily marketed for its presumed beneficial health effects.


Eligibility criteria:
inclusion criteria: * \>=45 and \<=75 years of age * body mass index \>=25.0 and \<40.0 kg/m2 exclusion criteria: * \ 75 years of age * body mass index \ 39.9 kg/m2 * plasma triglyceride \<125 mg/dl * history of or current significant organ system dysfunction * allergies or intolerances to meal ingredients * use of medications or dietary supplements that could confound the study outcomes * engaged in regular structured exercise \>150 min per week * alcohol use disorder * premenopausal women * persons who smoke * prisoners * inability to grant voluntary informed consent
tear film break-up time evaluation of fid 114657

Conditions: Dry Eye

Summary: to evaluate the effects of fid 114657 on tear film break-up time in dry eye patients.


Eligibility criteria:
inclusion criteria: 1. the informed consent document and hipaa privacy document must be read, signed and dated by the patient or legally authorized representative before conducting any procedures. 2. patients (minimum age 18) with dry eye. criteria for the diagnosis must include the following characteristics at visit 1 (screening): patients' self-assessment of dry eye status (answer of at least some of the time to the question, "how often have your eyes felt dry enough to want to use eye drops?");tfbut \ grade 1 for meibomian gland expression in both eyes; evidence of missing meibomian glands in both eyes. 3. able and willing to follow study instructions. 4. patients must have best-corrected visual acuity of 0.6 logmar or better in each eye as assessed using an etdrs chart at visit 1. 5. patients must not have used any topical ocular drops for approximately 24 hours prior to visit 1. exclusion criteria: 1. history or evidence of ocular or intraocular surgery in either eye within the past six months. 2. history or evidence of serious ocular trauma in either eye within the past six months. 3. current punctal occlusion of any type (e.g., collagen plugs, silicone plugs). 4. history of intolerance or hypersensitivity to any component of the study medications. 5. history or evidence of epithelial herpes simplex keratitis (dendritic keratitis); vaccinia; active or recent varicella viral disease of the cornea and/or conjunctiva; chronic bacterial disease of the cornea and/or conjunctiva and/or eyelids; mycobacterial infection of the eye; and/or fungal disease of the eye. 6. use of any concomitant topical ocular medications during the study period. 7. patients using systemic medications that may contribute to dry eye (e.g. cold and allergy medications, tricyclic antidepressants, hormone replacement therapies) may not be enrolled in the study unless they have been on a stable dosing regimen for a minimum of 30 days prior to visit 1. in addition, the dosing regimen must remain stable throughout the study. 8. ocular conditions such as conjunctival infections, iritis, or any other ocular condition that may preclude safe administration of the test article. 9. individuals unwilling to discontinue contact lens wear during the study period. contact lens wear must have been discontinued at least one week prior to visit 1. 10. enrollment of investigator's office staff, relatives, or members of their respective households; or enrollment of more than one member of the same household. 11. participation in an investigational drug or device study within 30 days of entering this study.

Keywords: tear film break-up time
impact of b. bifidum 900791 intake on breast milk characteristics of obese mothers

Conditions: Maternal Obesity

Summary: human breast milk harbours a specific microbiota including bacteria from the lactobacillus and bifidobacterium genera, that contribute to the bacterial colonization of the infant gut in the post-natal period. an entero-mammary pathway has been suggested by which selected bacteria from the maternal gut would be transmitted to the mammary gland through dendritic cell trafficking by the lymphatic pathway. accordingly, some studies have detected the presence of probiotic strains in breast milk from mothers who were consuming them. the administration of probiotic supplements to lactating mothers has also been shown to modulate milk concentrations of inflammatory markers and metabolic hormones, impacting positively the infant health. noteworthily, many of these inflammatory and hormonal biomarkers are altered in the breastmilk from pre-pregnancy obese mothers, compared with these who were normal-weight, possibly affecting the infant health. it is unclear whether the breast milk microbiota of obese mothers is altered and the impact of probiotic administration on the breastmilk microbiota and on the normalization of breastmilk alterations in obese mothers is unknown. based on these antecedents, the aim of this study is to determine if the administration of a b. bifidum 900791-containing foodstuff to mothers during the perinatal period normalizes the breast milk concentrations of interleukin (il)-6, c-reactive protein (crp), insulin, adiponectin and resistin, and the microbiota of obese mothers, compared with normal-weight mothers.


Eligibility criteria:
inclusion criteria: * women in their last month of pregnancy, who were normal-weight (18.5\ 30kg/m2) before pregnancy, and their children women recruited should have expressed their wish to have their child through normal delivery, and to breastfeed at least during the first month post-partum. exclusion criteria: * women with chronic diseases (type 2 diabetes, renal diseases, autoimmune diseases, tumor, chronic inflammatory diseases, etc.). * women with a history of digestive surgery. * women whose children are hospitalized more than 24hours in the neonatal unit * women who require antibiotic treatment during the perinatal period.

Keywords: obesity breast milk probiotic il-6 crp insulin adiponectin resistin breastmilk microbiota bifidobacterium
liposomal bupivacaine in total knee arthroplasty

Conditions: Pain, Postoperative; Arthroplasty, Replacement, Knee; Osteoarthritis

Summary: liposomal bupivacaine is a novel local anesthetic designed for prolonged pain relief. despite its long-acting analgesic potential, liposomal bupivacaine is significantly more expensive than other local anesthetic alternatives. the primary aim of this investigation is to examine whether or not liposomal bupivacaine provides superior pain relief or clinically significant opioid-sparing effects versus a control to justify its cost.


Eligibility criteria:
inclusion criteria: * patients undergoing a primary unilateral total knee arthroplasty by the pi of the trial exclusion criteria: * patients with a sensitivity to marcaine * pregnant or lactating women * non-english speaking individuals
a wraparound case management program for youth injured by violence

Conditions: Intentional Injury

Summary: this is a feasibility study of a wraparound case management program for youth injured by violence. youth (aged 10-24) who have been injured by violence and visit the emergency department will be offered a support worker who will provide wraparound case management. this study is designed to assess the feasibility of recruitment, enrollment and follow-up.


Eligibility criteria:
inclusion criteria: 1. age 10 - 24 and 2. presentation to an ed or trauma floor with an injury caused by violence (defined as an injury inflicted by someone else and one of a gunshot wound, stab wound, injury due to blunt object, or injury due to bodily force). exclusion criteria: 1. unable to consent due to language or brain injury, 2. sexual assault, 3. child abuse 4. self-inflicted injury, 5. subject is under arrest or 6. non-resident of winnipeg.

Keywords: youth violence injury emergency department intervention
uva brain and aortic aneurysm study

Conditions: Intracranial Aneurysm; Abdominal Aortic Aneurysm

Summary: the purpose of this study is to examine the percentage of patients who present with abdominal aortic aneurysms (aaa) will also have intracranial aneurysms (ia) and conversely; to examine the percentage of patients who present with intracranial aneurysms will also have abdominal aortic aneurysms.

the investigators have previously generated estimates for cost effectiveness of each arm of this reciprocal screening protocol based on literature dervied estimates of coprevalence and other key factors in a decision tree model to compare costs and outcomes. they measured expected outcomes using quality-adjusted life years (qaly) and the incremental cost-effectiveness ratios (icer). the current study will involve establishment of the true co-prevalence and recalculation of the icers and qalys. based on their literature derived models we previously found an icer of $34.01/qaly for aaa screening in ia patients and an icer of $6,401.91/qaly for ia screening in aaa patients. both of these are well below the societal accepted threshold of $60,000/qaly. however, both models were sensitive to co-prevalence. in the current study the investigators will therefore determine the actual cost-effectiveness of performing additional radiographic procedures and genetic counseling. the investigators will also bank dna and rna for future research.

Eligibility criteria:
inclusion criteria: * age 18 years or older * clinical and radiographic diagnosis of either abdominal aortic aneurysm (aaa) or intracranial cerebral aneurysm (ia). aneurysm may be symptomatic (s/p rupture or mass effect) or asymptomatic (detected as part of screening or incidentally discovered. aneurysms int he brain may be multiple. aaa will be defined as \>= 3 cm by any imaging modality. ia will be defined as \>= 3 mm on any imaging modality. * able to provide a valid informed consent (self or legally authorized representative) exclusion criteria: * contra-indication for mri/a (embedded metal, intractable claustrophobia, pacemaker, etc.) * intracranial aneurysm associated with arteriovenous malformation * clinical or radiographic diagnosis of mycotic aneurysm * substantial pre-existing neurological or psychiatric illness that would confound neurological assessment or other outcome assessment. * other serious conditions that make the patient unlikely to survive long enough to benefit from the screening program. * inability to follow the protocol or return for screening test or genetic counseling. * unwilling to have reports from imaging and genetic counselor sent to a clinician (pcp, testing surgeon, etc) note: pregnancy is not a reason to exclude, but imaging done for the study will be postponed until after the subject has given birth.

Keywords: aneurysm intracranial aneurysm abdominal aortic aneurysm
clinical and laboratory assessment of iron overload in sickle cell anemia and sickle cell thalassemia

Conditions: Sickle Cell Anemia; Sickle Cell Thalassemia

Summary: iron overload is well study in thalassemia patients and it's not only related to blood transfusions, since intestinal iron absorption is also increased in those patients. sickle cell patients didn't developed significant clinical symptoms and signs of iron overload in spite frequent transfusions. the purpose of this study is to assess the iron overload in sickle cell anemia and sickle cell thalassemia patients using clinical parameters and laboratory studies including non transferrin binding iron, labile iron and hepcidin, in order to determine the cardiac and liver iron.


Eligibility criteria:
inclusion criteria: * all the patients with sickle cell anemia and sickle cell thalassemia that are treated and followed up at the pediatric hematology unit.

Keywords: sickle cell anemia sickle cell thalassemia iron overload non transferrin binding iron hepcidin
enchasing polyp detection: the effect of adding polyp detection attachment device to computer aid detection system.

Conditions: Colon Cancer Screening; Colon Cancer Surveillance

Summary: despite the widespread use of colonoscopy, the ongoing challenge of potentially missing polyps remains. previous studies have independently shown that both endocuff, a colonoscope attachment device for polyp detection, and computer-aided detection (cade) systems have individually demonstrated enhanced lesion detection and safety. this study seeks to evaluate the efficacy of combining the endocuff cade versus using cade alone in colonoscopy procedures for colorectal cancer screening and surveillance. this research project aims to ascertain whether the synergistic application of these technologies yields superior outcomes.


Eligibility criteria:
inclusion criteria: * age \> 18 * patients scheduled for an outpatient screening or surveillance colonoscopy. exclusion criteria: * patients who require diagnostic colonoscopy (e.g.; anemia or gi bleeding). * patients requiring deep ileal intubation. * patients with inflammatory bowel disease. * patients with radiotherapy-induced colitis or other severe colitis. * patients with colonic strictures. * patients with acute diverticulitis. * patients with large bowel obstruction. * patients scheduled for therapeutic colonoscopy (e.g., planned endoscopic mucosal resection for known polyps). * patients scheduled for assessment of a known colonic lesion. * patients with a known history of hereditary polyposis syndrome or untreated colon cancer. * patients with a history of colon resection. * patients on continuous anti-thrombotic therapy * pregnancy. * patients who are ineligible for colonoscopy due to medical or psychiatric conditions. * patients who are vulnerable or unable to consent

Keywords: colon cancer screening colon cancer surveillance computer-aided detection of adenoma colonoscope attachment device endocuff