Kornimate/medical-research-clean huggingface dataset:
how simplified language affects comprehension and learning in young autistic children

Conditions: Autism Spectrum Disorder

Summary: the long-term study goal is to experimentally evaluate the components (and likely active ingredients) of early language interventions for young children with asd. the overall objective is to determine how single-word and telegraphic simplification affects real-time language processing and word learning in young children with asd (relative to full, grammatical utterances). the proposed project will investigate three specific aims: 1) determine how single-word and telegraphic simplification affects language processing. 2) determine how single-word and telegraphic simplification affects word learning. 3) evaluate child characteristics that may moderate the effects of linguistic simplification on language processing and word learning. aim 1 will test the hypothesis that children with asd will process full, grammatical utterances faster and more accurately than single-word or telegraphic utterances. aim 2 will test the hypothesis that full, grammatical utterances will support word learning better than telegraphic or single-word utterances. aim 3 will test the hypothesis that language and cognitive skills significantly moderate the effects of linguistic simplification on language processing and word learning in young children with asd.


Eligibility criteria:
inclusion criteria: * existing or suspected autism spectrum disorder, confirmed through ados-2 * english as primary language * 1-4 years old exclusion criteria: * known genetic condition (e.g., down syndrome, fragile x) * cerebral palsy * acquired brain injury * uncorrected vision or hearing impairment

Keywords: language autism intervention processing learning early childhood treatment early intervention telegraphic language input looking-while-listening eye tracking comprehension neurodevelopmental disorders
pre-hospital agitation and sedation trial: a randomized controlled trial of haloperidol versus midazolam for the sedation of the agitated patient

Conditions: Agitation

Summary: prehospital agitation and sedation trial (phast) * the goal of the phast is to demine whether haloperidol is superior to midazolam for the sedation of agitated patients in the prehospital environment * the primary outcome is the time to a richmond agitation and sedation scale (rass) ≤1 o the rass is a well validated standardized score to measure a patient's agitation * the secondary outcomes are * time until rass returns to 0 or 1 if rass \<0 * need for additional sedation * adverse effects (need for intubation, arrhythmia) * mercy ems will be the only ems agency in the commonwealth of pennsylvania carrying haloperidol * identification of potential study patients will be per state protocols * exclusion criteria for the study * age \<18 * pregnant * allergic to study medication * transport to hospital other than mercy fitzgerald hospital * unable to reach medical command prior to giving medication * when a paramedic identifies a possible study candidate, the paramedic will consult medical command to see if the patient is appropriate for the study * if the medical command agrees the patient is appropriate for the study, patients will be randomized to * odd days: haloperidol 5mg im (age \<65) or haloperidol 2.5 mg im (age ≥65) * even days: midazolam 0.05 mg im to maximum of 5mg im (age \<65) or maximum of 2.5mg (age ≥65) * the rass will be documented by the prehospital providers every 5 minutes until arrival at the hospital * once the patient arrives at the ed, the rass will be documented in picis® by the emergency department nurse at the time of triage and at a minimum of hourly until the rass =0 or 1 for 2 consecutive hours * questions may be directed to dr. isenberg at disenberg@mercyhealth.org or at (267) 205-6453 richmond agitation sedation scale rass rass description * 4 combative, violent, danger to staff * 3 pulls or removes tube(s) or catheters; aggressive * 2 frequent non-purposeful movement * 1 anxious, apprehensive, but not aggressive 0 alert and calm * 1 awakens to voice (eye opening/contact) \>10 sec * 2 light sedation, briefly awakens to voice (eye opening/contact) \<10 sec * 3 moderate sedation, movement or eye opening. no eye contact * 4 deep sedation, no response to voice, but movement or eye opening to physical stimulation * 5 unarousable, no response to voice or physical stimulation


Eligibility criteria:
exclusion criteria: * age \<18 * pregnant * allergic to study medication * transport to hospital other than mercy fitzgerald hospital * unable to reach medical command prior to giving medication

Keywords: time to sedation of agitated patients
intermittent hypoxemia, lung function decline, morbidity, and mortality in copd (prosa study).

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: this study aims to analyze if patients with chronic obstructive lung disease who experience a decline of blood oxygen saturation during physical exercise have a disease course different from that of copd patients who do not experience a decline in blood oxygen saturation during exercise. patients will be followed for a total of 3 years.

the major aim of the study is to test whether intermittent hypoxaemia is a major driver of the progression of chronic obstructive lung disease (copd). the second aim is to analyse whether dysregulation of the l-arginine / dimethylarginine pathway is a mechanistic link between intermittent hypoxemia and lung function decline, and whether plasma biomarkers are suitable to identify copd patients at high risk of rapid lung function decline and mortality.

Eligibility criteria:
inclusion criteria: 1. patients of both sexes with a diagnosis of chronic obstructive lung disease (copd) stages 2-3, groups b and e according to gold 38 as assessed by their primary family doctor or pneumology specialist who are treated with long-acting bronchodilators on a stable dose for at least four months prior to inclusion into the study; 2. age at inclusion 18 - 80 years; 3. physical ability and willingness to perform 6-minute walk testing and bicycle ergometry testing; 4. signed written informed consent form exclusion criteria: 1. participation in another clinical study within the last 3 months before inclusion into the present study; 2. any somatic or psychic disease that may hamper participation in the study or compliance with the study protocol (at the investigator's discretion); 3. any somatic disease that puts the patient at increased risk when performing the exercise tests or impairs the patient's ability to properly perform the exercise tests, like advanced coronary artery disease, advanced chronic heart failure, uncontrolled hypertension, orthopaedic, or neurological diseases (non-exclusive list of examples); 4. any disease or health condition that reduces the patient's life expectancy to less than the expected time frame of this study, other than chronic obstructive lung disease (at the investigator's discretion); 5. pregnancy or nursing.

Keywords: lung function, prognosis, exercise testing, spirometry
prognosis and risk factors of gastric cancer in patients with intestinal metaplasia

Conditions: Stomach Cancer

Summary: this prospective cohort study aims to assess the incidence of gastric cancer in patients with intestinal metaplasia in body of stomach or angular incisure. as secondary objectives, among the patients included in the cohort, the study will: * assess the incidence of low grade dysplasia, * assess the incidence of high grade dysplasia in patients with low grade dysplasia, * identify risk factors of progression to dysplasia and gastric cancer.

this is a french nationwide prospective study. 2000 patients will be enrolled by 3500 gastroenterologists, either in private or public healthcare settings. all patients will undergo an endoscopy with gastric sampling in order to biopsy: * 1 sample each in anterior and posterior surfaces of antrum * 1 sample in lesser curvature * 1 sample each in anterior and posterior surfaces of body of stomach patients will be contacted every 12 months and followed up for 3 years by their gastroenterologist. the follow-up will be performed according to the 2012 european guideline on management of precancerous conditions and lesions in the stomach (endoscopy 2012, jan; 44(1): 74-94). patients will also receive a 6-monthly phone call from their gastroenterologist in order to know if any gastric symptom has appeared. at any time, patients should contact their gastroenterologist to inform them about new gastric symptoms. during follow-up, the frequency of gastroscopy with biopsy depends on the stage of lesions: * patients with intestinal metaplasia: gastroscopy at 36 months. * patients with dysplasia: an annual gastroscopy will be performed. in case of low grade dysplasia confirmed by pathologist at inclusion, patients will undergo 1 year later another endoscopy with gastric sampling in order to biopsy: * 4 circumferential samplings of antrum * 1 sampling of curvature * 4 circumferential samplings of body of stomach

Eligibility criteria:
inclusion criteria: * age \> 18 years. * gastroscopic examination with biopsy in the 6 months preceding inclusion, with intestinal metaplasia in body of stomach or angular incisure. * patient does not oppose to participate to the study. exclusion criteria: * progressive concomitant disease with life expectancy less than 3 years. * gastric cancer at the time of inclusion. * patient with previous oesophageal cancer. * patient with previous gastric surgery. * anticipated obstacles to follow-up during the study (e.g., understanding difficulties, homelessness).

Keywords: stomach cancer gastric intestinal metaplasia prospective cohort low grade dysplasia high grade dysplasia prognosis factor gastric cancer risks
brain oxygenation during cardiopulmonary resuscitation

Conditions: Cardiac Arrest, Out-Of-Hospital

Summary: the study is aimed to assess (a) the incidence of hyperoxia at the point of return of spontaneous circulation (rosc) and (b) the role of arterial blood oxygen partial pressure to brain oxygenation during out-of-hospital cardiac arrest. 80 adult patients will be recruited in a physician staffed helicopter emergency medical services. brain regional oxygen saturation and invasive blood pressure are monitored until hospital admission and arterial blood gases are analyzed immediately when the unit arrives to the patient and again at the time of rosc.


Eligibility criteria:
inclusion criteria: * out-of-hospital cardiac arrest of presumed cardiac origin * resuscitation will be continued at least 5 minutes (if return of spontaneous circulation not achieved earlier) after arrival of physician team exclusion criteria: * do-not-attempt-resuscitation (dnar) order or withdrawal of treatment by prehospital critical care physician * return of spontaneous circulation achieved before physician-led critical team arrives * external cause for cardiac arrest (e.g. trauma, suffocation) * workload too high or environment too dangerous to perform study procedures
mind diet and cognitive function in adults with mci

Conditions: Mild Cognitive Impairment; Cognitive Function; Cognitive Decline

Summary: to examine the effects of a 1-year cluster-randomized controlled intervention of mind diet on cognitive function among 240 participants with mild cognitive function (mci) aged 50 years and above from 4 communities.

the current study is a 1-year cluster-randomized controlled intervention trial designed to examine whether the a localized modified mediterranean-dietary approaches to stop hypertension (dash) dietary intervention for neurodegenerative delay (mind) diet will improve cognitive function among 240 participants with mci from 4 communities. the modified mind diet recommends 11 brain healthy food groups (green leafy vegetables, dark red and yellow vegetables, other vegetables, nuts, berries, beans, whole grains, seafood, poultry, olive/tea-seed oil and green tea) and limits intake of 4 unhealthy food groups (red meat and products, animal oil, pastries and sweets, and fried/fast food). this study will randomly assign 240 mci participants to two groups: a) mind diet intervention group and b) control group, and estimate the cognitive and biological impacts of the 1-year intervention.

Eligibility criteria:
inclusion criteria: * at risk of cognitive decline: cognitive performance at the mean level or slightly lower than expected for age with no dementia (ad8\>=3 and/or 5-min moca \< 11) * free of physical disabilities that preclude participation in the study * willing to complete all study-related activities for 24 months * willing to be randomized to either intervention group exclusion criteria: * allergic to more than one type of food (nuts, berries, olive oil, or fish) * diagnosed of dementia, severe diabetes mellitus, cardiovascular disease, cancer, thyroid disease, kidney disease, or liver disease * diagnosed of major depression or other neuropsychological diseases * severe loss of vision, hearing or communicative ability * substance abuse within 6 months or heavy alcohol consumption (\> 2 drinks/day for women; \> 3 drinks/day for men).
first - study of pegfilgrastim administered in the first and subsequent cycles of myelosuppressive chemotherapy

Conditions: Neutropenia

Summary: the purpose of the study is to assess the impact of first and subsequent cycle pegfilgrastim on neutropenia events (such as hospitalizations, dose reductions and delays) in patients receiving myelosuppressive chemotherapy.


Eligibility criteria:
inclusion criteria: - pathologically confirmed diagnosis of the following malignancies: breast, non-hodgkin's lymphoma (nhl), hodgkin's disease, ovarian, colorectal, lung or other - planned administration of a new myelosuppressive every 14 (q14), q21, or q28 day chemotherapy - written informed consent for participation in the study before any study-specific procedures are performed, including screening and registration exclusion criteria: - planned concomitant therapeutic radiation - diagnosis of acute or chronic leukemia or myelodysplastic syndrome - prior stem-cell transplantation (includes bone-marrow transplantation) - medical diagnosis of chronic neutropenia of any cause not related to cancer - current cytotoxic, biologic, or immunologic therapy for unrelated conditions - subject has active infection requiring treatment - known hiv-positive subjects - subject of child-bearing potential is evidently pregnant (e.g., positive hcg test) or is breast feeding - subject of child-bearing potential is not using adequate contraceptive precautions - known sensitivity to e. coli derived drug products (e.g., filgrastim, humulin® insulin, l-asparaginase, humatrope® growth hormone, intron a®) - any psychiatric, addictive or other kind of disorder which compromises the ability of the subject to give written informed consent and/or to comply with study protocol procedures - subject is currently enrolled in, or has not yet completed at least 30 days since ending another device or drug trial(s) or is receiving, or plans to receive, other investigational agent(s) not approved by the food and drug administration (fda)

Keywords: phase 4 clinical trial chemotherapy neulasta® oncology malignancy
ffoct for the diagnosis of prostate cancer

Conditions: Patients With PSA Level 4.0 ng/mL

Summary: primary objective : the primary objective is to evaluate the diagnosis performance of ffoct for cancer detection in patients undergoing trus prostate biopsy, as compared to standard pathological evaluation. secondary objective: * evaluate predictive values of ffoct for cancer detection on prostate biopsy cores * evaluate the value of ffoct for cancer characterization on prostate biopsy cores * evaluate the reproducibility of ffoct evaluation for cancer detection on prostate biopsy cores * evaluate the learning curve of ffoct evaluation on prostate biopsy cores * evaluate ffoct procedure time

research in optical imaging has led to the development of the full field optical coherence tomography (ffoct) technology, which allows to image fresh tissues up to a depth of a few hundreds microns. the system is a microscope coupled with an interferometer. a halogen light source is used to illuminate the tissue specimen and a reference mirror. the light retro diffused by the specimen is combined with the light reflected by the mirror, and the interference signal is measured. multiple grey scale images are obtained and automatically stitched to obtain a complete slide throughout the specimen. the feasibility of the technique has been reported in various pilot studies, as well as the absence of any potential tissue harm and subsequent pathological artifact caused by the process. ffoct could be used as an additional detection tool for prostate cancer screening. the use of extended systematic trans-rectal ultrasound-guided (trus) prostate biopsies has led to over-diagnosis and over-treatment. also, the number of unnecessary biopsies has increased, along with the morbidity of the procedure. performing a "pre-pathological" evaluation of biopsy cores during the biopsy procedure would be of significant help to determine the nature of targeted areas and guide the number of biopsies to perform. we hypothesize that ffoct imaging of prostate biopsy cores would allow a cancer detection rate not statistically different from pathological analysis.

Eligibility criteria:
inclusion criteria: * - patient aged 45 to 75 years old included * - psa level 4.0 ng/ml * - patient referred for trans rectal ultrasound-guided prostate biopsy with additional mri-targeted biopsies * - patient no opposed to participate in the study * patient affiliated to the french national social security system exclusion criteria: * known prostate cancer * patients unable to understand the course of the study

Keywords: cancer prostate psa biopsies ffoct procedure
evaluation of the effect of surgical drapes on intraoperative hypothermia

Conditions: Hypothermia

Summary: this study was planned to investigate whether the wetness of surgical drapes (disposable and resusable drapes) used in the intraoperative period causes hypothermia.

after being informed about the study and potential risk all patients giving written informed consent then the study started. patients who will undergo elective, gastrointestinal and other major abdominal surgery were included in the study. after patients were randomized by the investigator, patients were covered with disposable or reusable surgical drapes in accordance with hospital procedure. the body temperatures of the patients were followed for 2-6 hours as tympanic and esophageal. in addition, pre- and postoperative surgical drapes, sponges, compresses were measured with precision scales.

Eligibility criteria:
inclusion criteria: * asa 1-2-3 * patients with abdominal surgery * patients receiving general anesthesia exclusion criteria: * unwanted to participate in the study * patients over 70 years of age * presence of central (high) fever originating from the central nervous system resulting from conditions such as cerebrovascular disease, cerebral trauma, intracranial surgery, epilepsy or acute hydrocephalus * abnormalities of thermoregulation such as hypothyroidism, hyperthyroidism, history of malignant hyperthermia, or neuroleptic malignant syndrome * presence of infectious fever * asa 4 and above * emergency surgery * patients receiving pre-operative chemotherapy * having problems such as tearing and perforation of the covers during the work. * patients being hyperthermic in the intraoperative process

Keywords: hypothermia perioperative nursing operating room nursing unintended hypothermia
effects of lumbopelvic stabilization-based physiotherapy and rehabilitation training in duchenne muscular dystrophy

Conditions: Duchenne Muscular Dystrophy (DMD); Lower Urinary Track Symptoms

Summary: this study aims to examine the effectiveness of supervised lumbopelvic stabilization in relation to factors associated with lower urinary tract symptoms in children diagnosed with duchenne muscular dystrophy (dmd) who have lower urinary tract dysfunction. children aged between 8 and 12 years, at stages 1-4 according to the vignos scale, and who have a score of 8.5 or higher on the dysfunctional voiding symptom score (dvss), will be included in the study. demographic information will be collected through a general assessment form, while lower urinary tract symptoms will be assessed using the dvss, a researcher-developed evaluation form, and a three-day bladder diary. bowel symptoms will be evaluated using the rome iv criteria and a seven-day bowel diary. physical performance will be assessed via the timed up and go test and gower's test, muscle strength using the microfet2 hand dynamometer, lumbar lordosis angle with a bubble inclinometer, participation in daily living activities via the barthel index, and perceived well-being of both the child and the parent will be assessed using the faces rating scale. participants will be randomly assigned to two groups (treatment and active control) using a block randomization method. in the active control group, children will receive only urotherapy education. in the treatment group, children will receive supervised, online, lumbopelvic exercise-based physiotherapy and rehabilitation sessions, in addition to urotherapy, conducted by a physiotherapist. the sessions will last eight weeks, with a total of 24 sessions. at the end of the eight-week period, both groups will be re-evaluated using the same assessment methods. intra-group and inter-group comparisons will be completed using appropriate analytical methods.


Eligibility criteria:
inclusion criteria: * having been diagnosed with dmd by a specialist physician, * having received a score of 8.5 or higher on the voiding disorders symptom score (vmss), * being between the ages of 8-12, * continuing ambulation (vignos scale stage 1-4), * volunteering to participate in the study by parents and reading and signing the informed consent form. exclusion criteria: * having another neuromuscular disease diagnosed other than dmd and/or accompanying dmd, * having family and/or child having cooperation problems in completing the evaluations for any reason, * lack of internet infrastructure or technical infrastructure that may cause difficulty in continuing distance education/follow-up, * having difficulty in understanding and speaking the turkish language.

Keywords: duchenne muscular dystrophy lower urinary tract symptoms urotherapy lumbopelvic exercise physiotherapy