Kornimate/medical-research-clean huggingface dataset:
congenital cataract morphological classifications

Conditions: Congenital Cataract

Summary: photography is considered as one of the most important means to promote evidence-based medical practice in pediatric ophthalmology.this study is to investigate the feasibility of congenital cataract morphological classifications and monitoring using slit-lamp-adapted anterior segmental photography in a large cohort that included uncooperative children.

lens opacities in congenital cataracts have a wide range of presentations.therefore, it is important to find a method of recording, classifying and monitoring cataract morphologies that is feasible and safe in a large cohort of children with congenital cataracts, including uncooperative children. photography is considered as one of the most important means to promote evidence-based medical practice in pediatric ophthalmology. in this study, the investigators studied congenital cataract morphological classifications and monitoring using slit-lamp-adapted anterior segmental photography and evaluated its safety and feasibility in pediatric cataract patients registered in the childhood cataract program of the chinese ministry of health.

Eligibility criteria:
inclusion criteria: * children with pediatric unilateral/bilateral cataracts * children who were younger than 10 years of age exclusion criteria: * premature birth * microphthalmia * micro-or megalocornea * keratoconus * glaucoma * traumatic or complicated cataracts * vitreous and retinal diseases * any previous surgeries, and contraindication for pupil dilation and sedation

Keywords: congenital cataracts opacity location opacity shape classification clinical applicability
lesinurad and allopurinol combination extension study in gout

Conditions: Gout

Summary: this study will assess the serum uric acid lowering effects and safety of lesinurad in combination with allopurinol over a long-term timeframe.

this is a phase 3 extension study to assess the long-term efficacy and safety of lesinurad in combination with allopurinol in subjects who completed the double-blind treatment period in studies rdea594-301 and rdea594-302.

Eligibility criteria:
inclusion criteria: * subject is able to understand the study procedures and the risks involved and is willing to provide written informed consent before the first study related activity. * subject completed the double-blind treatment period in either study rdea594-301 or rdea594-302 and was actively receiving and tolerating study medication (lesinurad or placebo) and allopurinol at the month 12 visit. * subject is male or female; female subjects of childbearing potential must agree to use an effective non-hormonal method of birth exclusion criteria: * subject has any medical or psychological condition, which in the opinion of the investigator and/or the medical monitor, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol requirements, or to complete the study.

Keywords: gout
correction of head turn in idiopathic infantile nystagmus

Conditions: Infantile Nystagmus Syndrome

Summary: infantile nystagmus is involuntary, bilateral, conjugate and rhythmic oscillations of the eyes which may present at birth or develop within the first 6 months of life. it may be idiopathic appearing without visual or neurological impairment or may be secondary to an afferent visual defect such as foveal hypoplasia, congenital cataract, retinal dystrophy or optic atrophy. aiming at improving outcome of head turn in idiopathic infantile nystagmus, comparison between the efficacy and safety of graded anderson procedure and kestenbaum procedure is essential.

infantile nystagmus related abnormal head position is noted according to the axis, it can be anomalous horizontally (right or left head turn), vertically (chin up or down), torsionally (right or left head tilt) or in a mixed pattern. a head turn to right or left is the most common compensatory posture encountered in patients with infantile nystagmus with an eccentric null position. a prolonged head turn (ht) may interfere with the social interactions and the quality of life and may lead to skeletal deformities in the cervical spine with postural dysfunction and impaired movement pattern. thus, the correction of an abnormal head turn is important to enlarge the visual field, to eliminate the possibility of abnormal contracture of the neck muscles and to permit an adequate vision.various extraocular muscle surgeries have been advised to correct infantile nystagmus-related ht. despite being the most common surgical technique used till today for correction of head turn related to nystagmus, kestenbaum procedure has variable long- term results, limited success rate and involves four rectus muscles (recession/ resection). in graded anderson procedure, only yoke muscle recession is done based on the amount of initial head turn leaving two untouched muscles.

Eligibility criteria:
inclusion criteria: orthophoric patients with idiopathic infantile nystagmus related head turn (≥20 degrees - ≤ 45 degrees) that is verified at least twice in two separate visits. exclusion criteria: 1. patients with infantile nystagmus secondary to ocular diseases 2. patients with infantile nystagmus with associated strabismus. 3. previous squint, scleral buckling or glaucoma surgeries. 4. associated systemic or neurological disorders. 5. patients with anisometropia ≥ 5d. 6. patients with nystagmus attenuated at near
lavender oil aromatherapy for the treatment of acute anxiety during bone marrow biopsy procedures

Conditions: Hematologic Diseases

Summary: the purpose of this study is to assess the effectiveness of lavender oil as compared to standard of care (soc) to relieve anxiety in participants undergoing a bone marrow aspirate and biopsy procedure

bone marrow aspiration and biopsy (bmab) is a primarily outpatient procedure that is used to aid the diagnosis of hematological diseases. during the bmab, local anesthesia is used however, many recipients still commonly report pain. poorly-controlled pain has been shown to have adverse, long-lasting psychological effects and those receiving bmab are generally significantly anxious and concerned about pain when undergoing this procedure. previous clinical studies suggest that lavender oil aromatherapy is effective in lowering anxiety experienced by participants. it will be hypothesized that lavender oil aromatherapy will demonstrate benefit to participants suffering from anxiety during the bmab procedure. participants who are undergoing bmab and meet the inclusion criteria will be randomized to either receive aromatherapy via lavender oil before and during the duration of the bmab, or to a soc arm. the primary objective of this study is to assess the efficacy of lavender oil aromatherapy as compared to placebo aromatherapy to relieve acute anxiety in participants undergoing a bmab procedure secondary objectives of this study are: to assess the efficacy of lavender oil aromatherapy as compared to placebo aromatherapy to relieve acute anxiety in participants undergoing a bmab procedure to determine the feasibility of utilizing lavender oil aromatherapy during bmab in clinical practice.

Eligibility criteria:
inclusion criteria: * patients must have the ability to understand and sign a written informed consent document, and be willing to follow protocol requirements * eastern cooperative oncology group (ecog) performance status ≤ 1 * willingness to comply with all study interventions of lavender oil aromatherapy * anxiety \>3 on a 0-10 visual analog scale regarding the bone marrow biopsy/aspirate procedure exclusion criteria: * allergy to lavender oil * mental incapacitation (ex. stroke, brain metastasis etc.) that would cause inability to follow directions, in the opinion of the investigators * ongoing uncontrolled active psychiatric condition that would interfere in the conduct of the study (e.g., mood disorders, anxiety, psychosis disorders, or substance use), as determined by the patient's primary cancer team. * if a patient has a history of a psychiatric disorder, we will contact their primary cancer team to determine if their condition is controlled or uncontrolled, and if it will interfere with the study. * currently pregnant * recent changes in the past 2 weeks to medications prescribed for pain or anxiety
the association between overweight and oocyte diameter in women undergoing vitro fertilization

Conditions: Infertility; Obesity

Summary: we believe that there is an association between bmi and oocyte diameter in women undergoing ivf treatments. we plan to measure the oocyte diameter in 2 groups of women undergoing ivf. one group will have bmi 20-25 and the other group will have bmi above 30.


Eligibility criteria:
inclusion criteria: * ivf treated patients * bmi between 20-25 or over 30 exclusion criteria: * everyone else
psychological distress & stress in parents with preterm infants-a prospective study

Conditions: Preterm Birth; Pregnancy; Stress; Psychological Distress

Summary: the purpose of the present prospective study is the analysis of risk and protective factors of perinatal stress and psychological distress of parents with or without a preterm child. stress is measured biologically by cortisol levels and psychologically by a questionnaire. different outcomes of psychological distress (e.g. anxiety, depression, posttraumatic stress disorder, burnout) are measured by various questionnaires. we analyze the influence of different aspects as personality traits, social support, partnership.


Eligibility criteria:
inclusion criteria: * pregnant women and their partners from the 24th week of gestation on * 18 years of age exclusion criteria: * psychiatric, mainly psychotic diseases * drug abuse * severe neurological disorders * stillbirth
3-year study of menostar versus evista to prevent osteoporosis in post-menopausal women

Conditions: Osteopenia

Summary: the aim of this trial is to investigate whether the menostar patch is as safe and effective in the prevention of bone loss in postmenopausal women as raloxifen, a drug already registered for prevention and treatment of osteoporosis.

the study has previously been posted by schering ag, germany. schering ag, germany has been renamed to bayer schering pharma ag, germany.bayer schering pharma ag, germany is the sponsor of the trial.

Eligibility criteria:
inclusion criteria: * last (regular) menstrual period more than 5 years ago * relative good state of health * intact, normal uterus exclusion criteria: * bone and musculoskeletal diseases * clinically significant vertebral fracture within the last 12 months * pre-existing cardiovascular disease (e.g. uncontrolled high/low blood pressure, stroke, thromboembolic event etc) * uncontrolled diabetes mellitus (or treated with insulin) * uncontrolled thyroid disorders * relevant renal disorder or significant liver dysfunction (including cholestasis) * history of alcohol or drug abuse * history of immobilization of more than 2 months in the last 6 months * smoking of more than 10 cigarettes per day * unexplained uterine bleeding * known or suspected malignant or premalignant disease (e.g. cancer of breast or uterus, melanoma)
child and family outcomes and consumer satisfaction for online vs staff-delivered parenting intervention

Conditions: Childhood Disruptive Behavior Disorders; Oppositional Defiant Disorder; Conduct Disorder; Attention Deficit Hyperactivity Disorder; Parent-Child Interactions

Summary: this trial addresses a serious and all-too-frequent public health problem, namely early-onset disruptive behavior problems in young children. the focus is on testing an online treatment program which empowers parents to help their children to improve their mental health and behavioral functioning. at the conclusion of the study, the investigators will know whether the online-delivered program works as well as an established staff-delivered program, with respect to child disruptive behavior problems, parenting, parent/family stress, consumer satisfaction, and value analysis.

high-prevalence mental health problems require innovative strategies to broaden reach of evidence-based services. disruptive behavior problems (dbps), or conduct problems, in young children represent a major public health challenge that is not only highly prevalent but also, left untreated, heighten risk for adverse mental health and developmental outcomes in adolescence and adulthood. internet and online technology has considerable potential to help achieve such a goal. building on parenting interventions that have demonstrated impact on childhood dbps, this clinical trial compares an online-delivered intervention to a well-validated staff-delivered intervention, holding program content constant. both interventions are based on the triple p-positive parenting program. the sample includes families with a 3-7 year old child who has a pronounced level of dbps. the study makes use of a non-inferiority trial design to determine whether the online-delivered intervention yields as good outcomes as the well-established staff-delivered intervention with respect to childhood dbps, parenting, and parent/family stress. the study also includes a value analysis comparing the two interventions, accounting for provider and participant expenses as well as pre-implementation and implementation phases. this study is intended to shed light on the impact and potential benefits of a viable online parenting intervention for childhood disruptive behavior problems, but the results from this study are also intended to help the mental health field to better understand more broadly the potential advantages and disadvantages of online interventions over traditionally delivered interventions, particularly in light of expense minimization/effectiveness analysis.

Eligibility criteria:
inclusion criteria: * clinically elevated level of child disruptive behavior problems * parent resides with the child and has primary custody * parent has access to internet via computer, e-tablet, or smartphone exclusion criteria: * already in a family-based treatment * child has pervasive developmental disorder * parent under 20 years of age * parent has serious mental illness
cab-axl-adc safety and efficacy study in adults with nsclc

Conditions: Non-Small-Cell Lung Cancer

Summary: the objective of this study is to assess safety and efficacy of cab-axl-adc in nsclc

this is a multi-center, open-label, phase 2 study designed to evaluate the safety, tolerability, pk, immunogenicity, and antitumor activity of ba3011, a conditionally active biologic (cab) axl-targeted antibody drug conjugate (cab-axl-adc), alone and in combination with pd-1 inhibitor in patients with metastatic non-small cell lung cancer (nsclc).

Eligibility criteria:
inclusion criteria: * patients must have measurable disease. * age ≥ 18 years * adequate renal function * adequate liver function * adequate hematological function * have an eastern cooperative oncology group (ecog) performance status of 0 or 1. * life expectancy of at least three months. exclusion criteria: * patients must not have clinically significant cardiac disease. * patients must not have known non-controlled cns metastasis. * patients must not have had prior therapy with a conjugated or unconjugated auristatin derivative/vinca-binding site targeting payload. * patients must not have a history of ≥ grade 3 allergic reactions to mab therapy as well as known or suspected allergy or intolerance to any agent given during this study. * patients must not have had major surgery within 4 weeks before first ba3011 * patients must not have known human immunodeficiency virus (hiv) infection, active hepatitis b and/or hepatitis c. * patients must not be women who are pregnant or breast feeding.

Keywords: cancer
a phase 2 study of ya-101 in patients with multiple system atrophy

Conditions: Multiple System Atrophy

Summary: this is a phase 2, double-blind, placebo-controlled, multi-center, phase ii, dose escalation study to evaluate the safety, tolerability, pharmacokinetics and efficacy of ya-101 in subjects with multiple system atrophy.

the purpose of the study is to evaluate 2 doses of ya-101 compared to placebo in msa patients, including: 1) safety and tolerability, 2) pharmacokinetics, and 3) potential efficacy of ya-101.

Eligibility criteria:
inclusion criteria: 1. able to understand the process of the clinical trial and give informed consent for the participation of the study. 2. diagnosis of msa according to mds clinical criteria (wenning et al, 2022), including subjects with msa of either subtype (msa-p or msa-c). 3. males or non-pregnant, non-lactating females with no child-bearing potential, or agree to use 2 forms of contraception. 4. able to take oral medications. 5. able to ambulate without the assistance of another person. exclusion criteria: 1. positive urine test for drugs of abuse and/or alcohol test both at screening and day 1. 2. evidence of renal impairment or hepatic impairment. 3. subject with a mini-mental state examination (mmse) score of 24 or lower. 4. medical history includes severe systemic diseases such as cardiopulmonary failure, severe liver or kidney disease, and uncontrolled diabetes; significant central nervous system disorders like stroke, encephalitis, and epilepsy and severe head trauma; peptic ulcer in one year prior to screening. 5. positive results for active viral infections, including human immunodeficiency virus (hiv), hepatitis b, and hepatitis c.
effect of nefopam on acute postoperative pain in patients undergoing orthognathic surgery

Conditions: Pain; Orthognathic Surgery

Summary: the aim of this study is to determine the analgesic effect of perioperative nefopam on acute pain in patient undergoing orthognathic surgery.


Eligibility criteria:
inclusion criteria: * aged 20-60 years * undergoing elective orthognathic surgery exclusion criteria: * pregnancy * psychiatric disease * hepatobiliary or renal disease * monoamine oxidase inhibitor-taking patients

Keywords: pain orthognathic
facilitated referral for children screening positive for mental illness

Conditions: Mental Disorders; Mentally Ill Persons; Emergency Medicine

Summary: the purpose of this study is to find out how prevalent unidentified mental health issues are in the pediatric population that visits the emergency department in an urban city.

the purpose of this research study is to find out how many children in the emergency room have emotional issues and how many of them go unnoticed. in particular the study looks at how well a questionnaire for children and teenagers, the disc predictive scales, version iv (dps-iv) works and what is the best way to ask the questions. in addition, for children aged 9-17 this study will look at families' readiness to seek care when a problem is indicated.

Eligibility criteria:
inclusion criteria: * child must be with biological mother * child presenting to emergency department with an urgent but stable condition * child must be between the ages of 6 years and 18 years * child must have no prior history of behavioral health concerns or diagnoses exclusion criteria: * child has prior behavioral health history, diagnosis, or concerns * child not between ages of 6 years and 18 years of ages * child presenting without biological mother present * child acuity level outside of urgent but stable for presenting complaints

Keywords: mental disorders mentally ill persons emergency medicine emergency department screening
medication adherence and use of inhaler devices in patients with asthma or copd

Conditions: Asthma COPD

Summary: this study aims to evaluate the impact of a pharmacist-led intervention programme on medication adherence and use of inhaler devices on clinical outcomes of patients with asthma and copd attending a tertiary health facility in nigeria.

medication non-adherence in asthma and copd patients have been established to be very high, and along-side poor knowledge of proper use of inhaler devices, results in suboptimal disease control among these patients. studies evaluating the impact of a comprehensive intervention on medication adherence and inhaler usage on disease control are scare in developing countries. this study was a prospective single-blind quasi-randomized-controlled study among asthma and copd patients attending the chest out-patient clinic of the university college hospital, ibadan. the baseline questionnaire was administered to consenting patients to explore demographic and specific clinical characteristics, knowledge of the disease, current medications, medication adherence, knowledge of use of metered dose (mdis) and diskus inhalers, and asthma/copd control status using the asthma control test (act) and copd assessment test (cat) scales. subsequently, patients were assigned into intervention or control groups using odd or even number assignation. patients in the intervention group were followed up for two months via face to face interviews, short message services, and phone calls at one-weekly intervals, so as to provide education and counseling to resolve the identified gaps during the baseline interaction. descriptive statistics were used to summarize the data, while chi-square, t-test, fishers exact test and wilcoxon-signed ranked tests were used as appropriate to test for associations at p \< 0.05.

Eligibility criteria:
inclusion criteria: patients 18 years of age and older with a primary diagnosis of asthma or copd by a physician who are willing to complete the study and have telephone access exclusion criteria: all non-consenting patients and patients who are not on any medications at any point in the study
sleep disorders in children with adhd

Conditions: Attention Disorder With Hyperactivity (ADHD)

Summary: adhd is often associated with sleep difficulties. attention-deficit/hyperactivity disorder (adhd) is the most common problem presented to children mental health services. the disorder affects approximately 5 % of school-age children. the core symptoms of this disorder include varying degrees of inattention, impulsiveness and restlessness. in addition to the core symptoms, adhd is associated with other problems (e.g. academic underachievement, poor social relations and sleep disturbances). despite clinical observations of sleep problems in children with adhd, there is little empirical research on this topic. the prevalence, type of sleep problems, and significance of these sleep disturbances in children with adhd remain undocumented. the objective is to determine the relationship of sleep problems to attention deficit/hyperactive disorder, comorbid disorders, and the effect of stimulant treatment.


Eligibility criteria:
inclusion criteria: - we will compare a group of children with adhd, other psychiatric disorder, and a healthy group of children age 5 - 10 exclusion criteria: mental retardation -

Keywords: attention disorder with hyperactivity sleep stimulants actigraphy