Kornimate/medical-research-clean huggingface dataset:
acute effects of beetroot juice and caffeine co-ingestion on lower-limb strength and muscular endurance in females

Conditions: Beetroot Juice; Caffeine; Placebo; Beetroot Juice with Caffeine Co-ingestion

Summary: the aim of this study is to evaluate the acute effects of beetroot juice and caffeine, consumed individually or in combination, on lower-limb strength and muscular endurance in physically active women. the main questions it aims to answer are: * does the co-ingestion of beetroot juice and caffeine enhance lower-limb strength and muscular endurance more than either substance alone or a placebo? * how do the acute effects of beetroot juice interact with caffeine on physical performance? the study was conducted using a randomized, crossover design to evaluate the following four conditions: beetroot juice with placebo caffeine with placebo beetroot juice with caffeine placebo only each participant completed all conditions, with a sufficient washout period between sessions to eliminate potential carryover effects. this design allowed for a direct comparison of the acute effects of each supplementation strategy on lower-limb strength and muscular endurance. participant protocol participants consumed their assigned supplement on a single testing day for each condition. after supplementation, they performed standardized tests to measure lower-limb strength and muscular endurance. progress was monitored, and data from all conditions were collected to assess the acute effects of each intervention.


Eligibility criteria:
inclusion criteria: * minimal experience of six months of strength training * be familiarized with the exercise test: counter movement jump (cmj), barbell back squats, leg press and knee extension. exclusion criteria: * supplementation consumption * sports injuries

Keywords: beetroot juice nitrate caffeine resistance training dietary supplement female
functional exhaustion of t cells in covid19 patients

Conditions: T Cell Deficiency

Summary: the primary end-point of our prospective, observational study is to count t cells in patients with laboratory-confirmed covid-19 and healthy controls. in addition, the expression of t cell exhaustion marker was measured in covid-19 cases.

covid-19 caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2) has posed great threat to human health. t cells play a critical role in antiviral immunity but their numbers and functional state in covid-19 patients remain largely unclear. the immune response against viral infections depends on the activation of cytotoxic t cells that can clear infection by killing virus-infected cells, so boosting the numbers and function of t cells in covid-19 patients is critical for successful recovery. however, the factors which might cause the reduction in count, and the activation status of t cells in covid-19 patients, remain uninvestigated. thus demonstration of t cell exhaustion during covid-19 infection suggest that more urgent, early intervention may be required in patients with low t lymphocyte counts.

Eligibility criteria:
inclusion criteria: * diagnosis of covid-19 test positive; hospitalized subjects; both sexes; given informed consent. exclusion criteria: * no exclusion criteriae
management of borderline common bile duct stone

Conditions: Common Bile Duct Stone

Summary: evaluation of the best line of treatment of borderline cbd stones associated with gallbladder stones whether by conservative treatment or endoscopic stone extraction as regard complete clearance rate of the cbd stones followed by laparoscopic cholecystectomy. the secondary outcomes are overall complications related to each approach, technical difficulties and conversion rate during laparoscopic cholecystectomy and cost benefit relationship of each line of treatment.

enrolled patients in the study will be randomized to either conservative treatment or ercp and stone extraction. the randomization process will be done using closed envelop method and will be withdrawn by a nurse in the outpatient clinic. 1. patients in conservative treatment group will receive medical treatment in the form of antibiotics, analgesics and antispasmodics for 3 days. these patients will be followed up for improvement on the ground of clinical symptoms and serum bilirubin level and abdominal us for cbd stones. 1. improvement: if the stone spontaneously passes to the duodenum and cbd is clear completely from the stones proved by us, the patient will undergo laparoscopic cholecystectomy (lc) within 3 days. 2. no improvement: the patient will undergo ercp and then lc. 2. patients in ercp group will undergo ercp and wide papillotomy and stone extraction directly then laparoscopic cholecystectomy (lc) within 3 days.

Eligibility criteria:
inclusion criteria: inclusion criteria: 1. cbd diameter less than 10mm. 2. single or 2 stones in number. 3. size of stone 5mm or less. 4. serum bilirubin level less than 10 mg/dl . 5. sgpt, sgot less than 300. 6. associated gallbladder stones exclusion criteria: 1. previous cholecystectomy. 2. history of acute cholecystitis, pancreatitis, or cholangitis. 3. previous history of endoscopic sphincterotomy. 4. unfit patients for cholecystectomy. 5. no gallbladder stones. 6. patients with altered git anatomy.
adaptive radiotherapy in locally advanced non-small cell lung cancer (lartia trial)

Conditions: Non-Small Cell Lung Cancer

Summary: anatomical change of tumor during radiotherapy contributes to target missing. however, in the case of tumor shrinkage, adaptation of volume could result in an increased incidence of recurrence in the area of target reduction. this study aims to investigate the incidence of failure of the adaptive approach in locally advanced non-small cell lung cancer and, in particular, the risk for local recurrence in the area excluded after replanning.

concurrent chemoradiation is the standard of care for patients affected by locally advanced (la) nsclc. its superiority over radiotherapy alone or sequential chemoradiation has been proved in multiple phase iii randomized trials. in a meta-analysis of six randomized studies, concurrent chemoradiotherapy decreased locoregional progression by 6.1% at 5 years when compared with sequential chemoradiation. this resulted in an improvement in overall survival of 4.5% at 5 years that was possibly directly related to locoregional control. many patients however succumb to locoregional failure or distant metastases. thanks to modern radiotherapy techniques, some strategies manage the geometrical uncertainties of imaging, treatment planning, and treatment delivery and thereby improve target coverage with a much steeper dose gradient and less irradiated normal tissue. the introduction of image-guided radiotherapy reveals the occurrence of target changes during treatment, and although the percentage of patients who experienced regression is not high (range 25%-40%), the degree of regression is in the range of 29% to 40%, corresponding to a rate of tumor shrinkage per fraction of 0.79% to 1.65%. anatomical changes during radiotherapy might introduce discrepancies between the planned and delivered dose. currently, the literature reports only dosimetric experiences and lacks clinical data on outcome when patients are treated with the adaptive approach. this study aims to investigate the failure pattern in patients with la nsclc treated with concurrent chemoradiotherapy with an adaptive approach, in particular, to evaluate the risk for local recurrence in the area excluded during replanning.

Eligibility criteria:
inclusion criteria: * histologically or cytologically proven nsclc; * inoperable stage iiia/iiib disease and intrathoracic relapse after surgery; * positron emission tomography (pet)/computed tomography (ct) and/or total-body ct with contrast excluding metastatic disease (including brain); * no previous radiotherapy treatment; * eastern cooperative oncology group performance status of 0 to 1; * clinically measurable/evaluable disease; * minimum life expectancy of 12 weeks; * adequate respiratory, renal, hepatic and bone marrow function and non-contraindicative cardiovascular disease. exclusion criteria: * previous radiotherapy treatment * concurrent systemic disorders incompatible with chemotherapy or radiotherapy

Keywords: adaptive radiotherapy
alpha lipoic acid as an adjuvant treatment in acute phosphide poisoning

Conditions: Toxicity

Summary: the aim of this study is to evaluate efficacy and safety of alpha lipoic acid(ala) as an adjuvant in the management of patients with acute phosphide poisoning.

the study will be carried out following approval of the research ethical committee of tanta faculty of medicine on patients admitted to the poison control unit (emergency hospital, tanta university and emergency hospital, mansoura university) with acute phosphide poisoning in the period from january 2016 to january 2018. a written informed consent will be taken from each patient or his/her guardians (if the patient was unable to participate in the consent process). confidentiality of the data will be maintained by making code numbers for each patient. the investigators plan to conduct a randomized clinical trial to evaluate efficacy and safety of ala as an adjuvant in treatment of patients with acute phosphide poisoning. fifty patients will be randomized to ala or a non ala in a 1:1 ratio (25 patients in each group). ala will be given iv, as a dose of 600 mg/12 hours. patients will be monitored and a detailed documentation of any adverse effect due to ala therapy will be recorded. this intervention represents an added treatment to the existing standard of care. all patients will continue to receive standard treatment, which is determined by the attending physician who maintains clinical responsibility for all patients. it consists of patient resuscitation, gastric decontamination (with sodium bicarbonate, and activated charcoal \[1 g/kg, orally\] in the first 6 hours after onset of poisoning), adequate hydration and supportive treatment. all the patients will be followed up until discharge or death. all patients will be subjected to: i. history. ii. clinical examination. iii. laboratory investigations: at admission and repeated before discharge.

Eligibility criteria:
inclusion criteria: patients (male or female, aged 12 years or older) with symptomatic acute phosphide poisoning (deliberate or accidental), with diagnosis made on the basis of: 1. the typical clinical manifestations due to and following shortly after a single exposure to phosphide. 2. reliable identification of the compound based on the container brought by patient attendants or a subsequent confirmation by silver nitrate test for phosphine detection in stomach contents. exclusion criteria: * patients less than 12 years of age * pregnant and lactating women * patients with ingestion or exposure to other substances in addition to phosphide. * patients with other major medical conditions (e.g. cardiovascular disease, renal or hepatic failure). * patients presenting more than 6 hours of having consumed the phosphide compound (late presenters). * patients treated for acute phosphide poisoning in any medical center before admission.
study of brain-spinal cord neural connectivity in spasticity

Conditions: Spasticity, Muscle

Summary: little is known about the peripheral and central mechanisms of action of selective dorsal rhizotomy surgery for the treatment of spasticity. a better understanding of these mechanisms will enable us to improve the surgical procedure. this will require cortico-medullo-radiculo-muscular recordings never before performed and published in the literature, and the identification of variations in connectivity correlated with the clinic.


Eligibility criteria:
inclusion criteria: * patients aged 3 to 17 years included * scheduled for selective rhizotomy surgery * having received informed consent to participate in the study (written consent from both parents) * affiliated or beneficiary of a social security scheme exclusion criteria: * contraindications to selective rhizotomy * history of epilepsy * known neurological and/or psychiatric disorders with past and/or current medical treatment, or drug addiction * patient under legal protection * pregnant or breast-feeding women
effects of the variation in the time of systemic administration of metronidazole and amoxicillin associated to the non-surgical therapy of chronic periodontitis.

Conditions: Chronic Periodontitis; Clinical and Microbiological Effects

Summary: • background: peridontitis is a group of diseases with complex bacterial etiology that affects a large proportion of the chilean and worldwide population. its treatment, based on an anti-infective mechanical therapy including scaling and root planning procedures, has been highly effective in numerous short and long term clinical trials. the use of adjunctive systemic antibiotics has shown significant improvements in the initial therapy results of specific periodontal disease types or patient profiles. the synergic combination of metronidazole plus amoxicillin has been widely and successfully used for the treatment of aggressive and severe chronic periodontitis, demonstrating additional benefits in clinical and microbiological parameters over scaling and root planning alone. however, and despite its proven efficacy, there is a lack of evidence that evaluates the impact of antimicrobials intake at different times of the mechanical treatment, emphasizing the necessity of a study that compares, simultaneously, the variation of the adjunctive antibiotic effects when they are administered in different moments through the periodontal therapy course.


Eligibility criteria:
inclusion criteria: * a) age of 35 years old or more, b) at least 3 molars in the mouth, c) at least one site in three of the four quadrants with clinical attachment loss ≥ 3mm; d) at least 4 sites in different teeth with probing depth and clinical attachment level ≥ 6mm and bleeding on probing and at least 14 tooth present in the mouth exclusion criteria: * a) previous professional root planning; b) systemic/topic antibiotic or antiinflammatory treatment, at least 6 months prior to the initiation of the study; c) immunosuppression or need for antibiotic coverage for routine dental therapy; d) systemic condition that could affect the progression of periodontal disease (diabetes); e) pregnancy or lactation; e) allergy or intolerance to metronidazole or amoxicillin; f) smokers

Keywords: chronic periodontitis metronidazole plus amoxicillin mechanical periodontal therapy scaling and root planning periodontal treatment
a study to assess the efficacy, safety and tolerability of pregabalin in patients with symptoms of neuropathic pain

Conditions: Neuropathic Pain

Summary: the objective of this study is to evaluate the efficacy, safety and tolerability for pregabalin using a flexible, optimized dose schedule compared to placebo in relieving the symptoms of neuropathic pain.


Eligibility criteria:
inclusion criteria: * chinese outpatient of age 18 to 75 * at screening and baseline, a score of greater than 40 mm on the visual log scale of sf-mpq exclusion criteria: * neurologic disorders unrelated to neuropathic pain, which in the opinion of the investigator, might impair the assessment of pain * serum creatinine clearance greater than 60 ml/min
observational study regarding the necessity of inclusion of foot arch state together with the angiosome theory within the wound, ischemia and foot infection classification (wifi) to enhance the predictability of wound healing and decision making

Conditions: Chronic Limb-Threatening Ischemia; Diabetic Foot; Vascular Diseases

Summary: this study aims to assess the complete healing or healing progress of foot ulcer within 1 year where the patients will be classified according to foot arch state together with the angiosome theory and the wifi clinical stage to reflect the the necessity of inclusion of foot arch state together with the angiosome theory within the wifi classification to enhance the predictability of wound healing and decision making

patients will be classified according to their wifi stages into 3 groups and each group will be furtherly classified according to the patient's angiography of foot arch (whether by ct angiography or direct angiography) into: type 1: patent foot arch type 2: partially occluded foot arch which is divided into whether type 2a: patent dorsal tributary of foot arch type 2b: patent lateral tributary of foot arch type 3: totally occluded foot arch is divided into whether. type 3a: totally occluded foot arch with anterior tibial artery inflow. type 3b: totally occluded foot arch with posterior tibial artery inflow. during follow-up assessments, wound is classified to be within: anterior tibial artery, posterior tibial artery or both territories. wound healing states are often classified based on the progression of the healing process into each of the following categories such as: 1. complete healing: wound closure with the restoration of tissue integrity and absence of signs of infection. 2. partial healing: significant improvement but not complete closure; may involve reduction in wound size and improved tissue viability. 3. worsening: increase in wound size or signs of infection which may necessitates performing major amputation.

Eligibility criteria:
inclusion criteria: * diabetic foot in the form of gangrene, or a lower limb ulceration \>2 weeks duration. exclusion criteria: 1. age below 18 years old. 2. critically ill patients 3. patients with acute ischemia 4. patients with pure venous ulcer 5. patients with ulcer due to rheumatological disease 6. the patient has known sensitivity to heparin. 7. the patient has comorbid conditions that may limit their ability to comply with the follow-up requirements 8. the patient has an untreatable allergy to radiographic contrast material. 9. patient refusing consent
diabetes support project: couples intervention

Conditions: Type 2 Diabetes

Summary: research has shown that diabetes affects both the patient and family, and that support from family and partners helps diabetes patients manage their illness better. however, diabetes programs rarely involve the partner. the purpose of this study is to test an intervention that helps partners and patients who have type 2 diabetes better support each other. the intervention will be delivered over the telephone to reach more people. our hypothesis is that an intervention that targets the couple has a greater effect on health and well-being of patients than one that targets the individual patient alone.

diabetes is a serious illness that affects an estimated 7% of the us population, and is associated with life-threatening and disabling complications. research has shown that diabetes affects both the patient and family, and that support from one's spouse has been found to be the most important source of support during illness episodes. research clearly shows that marital interaction, i.e., how the support is given and received, impacts both marital quality and health functioning. despite the acknowledged importance of social support, the vast majority of chronic illness interventions target the individual patient. telephone counseling has been effectively used to enhance feasibility and target patients with many illnesses, and has many benefits including low cost, decreased subject burden, and the ability to reach a broader population. this study proposes a study of a telephone-administered behavior change that promotes couples communication and collaboration.

Eligibility criteria:
inclusion criteria: * diagnosis of type 2 diabetes * a1c level is \>=7.5% * age of target subject and spouse/partner is 21 years or older * married or together for \> 1 year * able to speak, read, and hear english * have a telephone exclusion criteria: * history of diabetes-related medical complications * history of active psychosis or dementia

Keywords: diabetes relationship social support telemedicine
discharge to home and chronic illness care pilot

Conditions: Solid Organ Transplant

Summary: the purpose of this study is to address a gap in knowledge needed for care of children with solid organ transplantation (sot) and their parents by combining mhealth technology with an individualized family centered self-management intervention (referred to as myfami). this study is critical to the increased understanding of hospital to home transition and family management at home with the potential to transform the way clinicians approach the care of complex chronic illness children and families.


Eligibility criteria:
inclusion criteria: * parent's child has undergone a heart, kidney, or liver transplant and is being discharged home from the hospital * the parent is english speaking (to date the tools being used have been validated for english participants only) * parent is 18 years of age or older * patient is 17 years of age and younger. exclusion criteria: * presence of significant communication or cognitive impairment on the part of the parent that would preclude completion of questionnaires based on self-report * parent and child has experienced the discharge to home transition from a previous transplant.

Keywords: pediatric solid organ transplant parents heart kidney liver
etco2 monitoring in acute self-poisoning

Conditions: Acute Intentional Overdose

Summary: there is no consensus on monitoring criteria in acute self poisoning. clinical scores, vital signs or lactatemia have failed to prove good predictive value. the main acute self poisoning complication is decreased consciousness level with consequent increased risk of hypoxemia and aspiration pneumonitis. several clinical studies have recently shown that etco2 monitoring can be valuable in procedural sedation in the emergency department. it is able to predict hypoxemia before any sao2 decrease and any complications related to these procedures. we therefore hypothesized that etco2 could help in acute self poisoning patients' monitoring in the ed.


Eligibility criteria:
inclusion criteria: * \>18y/o * acute self poisoning patients * patients requiring monitoring according to physician's opinion * patients not requiring invasive ventilation at ed admission exclusion criteria: * pregnant woman * patients deprived of liberty

Keywords: intoxication, overdose, poisoning, etco2, emergency medicine