Kornimate/medical-research-clean huggingface dataset:
metabolic profiling of type 1 diabetes mellitus in children and adolescents

Conditions: Type1diabetes

Summary: the aim of this study was to look for discriminating variation in the concentrations of small-molecule metabolites in the plasma of t1dm children compared with non-diabetic matched controls using proton nuclear magnetic resonance (1h-nmr)-based metabolomics.

type 1 diabetes mellitus (t1dm) is one of the most common pediatric diseases and its incidence is rising in many countries. recently, it has been shown that metabolites other than glucose play an important role in insulin deficiency and the development of diabetes. the aim of this study was to look for discriminating variation in the concentrations of small-molecule metabolites in the plasma of t1dm children compared with non-diabetic matched controls using proton nuclear magnetic resonance (1h-nmr)-based metabolomics. this cross-sectional study was set-up to examine the metabolic profile in fasting plasma samples from 7 t1dm children and 7 non-diabetic controls aged 8 to 18 years, and matched for gender, age and bmi. the obtained plasma 1h-nmr spectra were rationally divided into 110 integration regions, representing the metabolic phenotype. these integration regions reflect the relative metabolite concentrations and were used as statistical variables to construct (train) a classification model in discriminating between t1dm patients and controls.

Eligibility criteria:
inclusion criteria: * aged between 8 and 18 * normal-weight according to the international obesity task force (iotf) bmi criteria * fasted for at least 8 hours. exclusion criteria: * lipid-lowering drugs or other medication

Keywords: type 1 diabetes 1h-nmr spectroscopy metabolomics pediatrics
a multiple ascending dose study of daclatasvir (bms-790052) in hepatitis c virus genotype 1 infected subjects

Conditions: Chronic Hepatitis C

Summary: the primary purpose of this study is to assess the change in hepatitis c virus rna during dosing with daclatasvir and during the follow-up period in subjects with chronic hepatitis c infection


Eligibility criteria:
inclusion criteria: * chronically infected with hepatitis c virus (hcv) genotype 1 * treatment naive or treatment non-responders or treatment intolerant; and not co-infected with hiv or hepatitis b virus * hcv rna viral load of ≥10\*5 iu/ml * bmi 18 to 35kg/m² exclusion criteria: * any significant acute or chronic medical illness which is not stable or is not controlled with medication and not consistent with hepatitis c virus infection * hiv and/or hbv positive * major surgery within 4 weeks of study drug administration and any gastrointestinal surgery that could impact the absorption of study drug wocbp will be enrolled as in-patient for 16 days
chronic pain in covid-19 patients discharged from intensive care unit

Conditions: COVID-19 Pandemic; ICU; Pain, Chronic; Post Intensive Care Unit Syndrome; Neuropathic Pain

Summary: more than six million french were affected by sars-cov2 epidemic. about 20% of infected peoples were hospitalized, and about 5% were admitted to the intensive care units (icu) for severe sars-cov2 acute respiratory distress syndrome (ards) management. a spectrum of neuropsychiatric sequelae, specific for the icu exposure, was already described, including post-intensive care syndrome and persistent pain. a growing body of evidence suggests the impact of sars-cov2 exposure on the occurrence of neurological disorders and chronic pain syndrome development in covid-19 patients. taking together, one can expect a large number of patients discharged from icu after severe covid-19 with high prevalence of persistent pain and psychological disorders. to date, no study has evaluated neither the incidence of persistant pains in icu covid-19 survivors, nor pain phenotypes. the knowledge of such data is crucial in order to anticipate the management of such patients by specialized pain team, and to quantify the possible incurred burden of care. our study aims to evaluate the incidence of pain, pain localization and severity, associated pain-related psychological disorders, and to perform quantitative sensory testing in severe covid-19 patients, admitted to the icu for more than 48 hours and successfully discharged home during the first french pandemic wave.


Eligibility criteria:
inclusion criteria: * adults (\>=18 y.o.) * hospitalized in the icu for at least 48 hours * with sars-cov2 infection confirmed by polymerase chain reaction (pcr)/serology and/or a suggestive chest computed tomography scan * during the first wave of covid 19 from march to december 2020 at three investigator sites (2 in paris and 1 in lyon) * discharged alive from the icu * at least 6 months after discharge exclusion criteria: * patient refusal * inability to communicate or to have in-person appointment * death in the period from icu discharge to the first phone call for interview

Keywords: sars-cov2 intensive care unit critical illness survivors chronic pain covid long neuropathic pain quantitative sensory testing
migraine with aura and patent foramen ovale: identification of biomarkers to select patients in whom intervention would be beneficial (manet)

Conditions: Migraine Headache; PFO - Patent Foramen Ovale

Summary: this is a multicenter prospective observational study aimed to asses whether a specific prothrombotic platelet phenotype can discern migraine patients with pfo (patent forame ovale) - related symptoms from patients with incidental pfo. the study will also explore additional distinguishing features of causal and incidental pfo using a metabolomics approach. it involves the enrollment of well-characterized patient cohorts and an ex vivo approach using comparative cell biology models that reproduce the most critical aspects of the clinical scenario.

patients with pfo, who meet all the inclusion and none of the exclusion criteria, will be enrolled in the study. patients will undergo percutaneous correction of pfo and the following evaluations as clinical practice: * thrombophilic screening (factor v and ii and mthfr gene mutation); sampling for homocysteine, protein c (prot c), protein s (prot s) and antithrombin iii assay; * anatomic evaluation of the sia (saccular intracranial aneurysm) by color-doppler tt echocardiogram and intracardiac ultrasound for definition of the anatomy of the fossa ovalis: tunneled appearance; absence of sia aneurysm; bulging of the sia; convex right/left sia aneurysm; * quantification of right-left intracardiac shunt by ct doppler; * classification of migraine according to anzola scale at baseline visit, post pfo correction, at follow-up at 6 and 12 months. for the purpose of the study, blood sampling will be performed for evaluation of platelet reactivity; oxidative stress, aggregability, and deformability of red blood cells; and isolation of endothelial colony forming cells (ecfcs) for analysis of endothelial function. the latter in particular will be evaluated in comparison with the endothelial function of 30 subjects without known disease with age \> 18 years, enrolled as a control group. all analyses will be performed before pfo correction and 180 days after surgery.

Eligibility criteria:
inclusion criteria: * presence of pfo with right-left shunt at baseline \> 10 mes and during valsalva \> 20 mes * previous stroke or tia * positive mri for ischemic outcomes * sia aneurysm or residual chiari/eustachian valve network * thrombophilic screening positivity (mthfr/prot c/prot s) * cability to sign informed consent for study participation and adherence to planned clinical follow-ups exclusion criteria: * paroxysmal/refractory atrial fibrillation * tsa vasculopathy * left ventricular ejection fraction \<30% * moderate/severe mitral valve regurgitation * need for long-term anticoagulant therapy * allergy or intolerance to antiplatelet therapy * nickel allergy * severe chronic kidney disease (gfr \< 30 ml/min)

Keywords: platelets prothrombotic platelets phenotype metabolomics
regenerative endodontic procedure of immature permanent teeth with l-prf: a pilot controlled, clinical trial

Conditions: Endodontic Inflammation

Summary: this study evaluates the impact of autologous 'leucocyte and platelet rich fibrin' (l-prf) on the periapical bone healing and further root development of infected immature permanent teeth. in the test group regenerative endodontic procedure (rep) is performed with l-prf as scaffold, in the control group rep without l-prf is performed .

regenerative endodontic procedures are biologically based procedures designed to restore function of a damaged and nonfunctioning pulp by stimulation of existing stem and progenitor cells present in the root canal and/or the introduction and stimulation of new stem and dental pulp progenitor cells into the root canal under conditions that are favorable to their differentiation and reestablishment of function. l-prf has the potential advantage of creating a bioactive construct that stimulates the local environment for differentiation and proliferation of these stem and progenitor cells. we have designed this confirmatory study to test the hypothesis that the use of l-prf in rep of infected permanent immature teeth will accelerate periapical bone healing and stimulate the root maturation.

Eligibility criteria:
inclusion criteria: * provision of informed consent * permanent immature teeth with weak root canal walls (hopeless prognosis) * patients younger than 25 years exclusion criteria: * - unlikely to be able to comply with the study procedures, as judged by the investigator. * patients older than 25 years * deciduous teeth * permanent (immature) teeth that can be treated by a "regular" root canal treatment/ apexification * known or suspected current malignancy * history of chemotherapy within 5 years prior to study * history of radiation in the head and neck region * history of other metabolic bone diseases * a medical history that makes rep unfavorable * involvement in the planning and conduct of the study * previous enrolment in the present study

Keywords: regenerative endodontics platelet rich fibrin
chuna manual treatment for patients with primary dysmenorrhea primary dysmenorrhea

Conditions: Primary Dysmenorrhea

Summary: this study is a randomized controlled trial that compares 30 patients with primary dysmenorrhea by assigning them in a 1:1 ratio between patients treated with a chuna therapy strategy and patients treated with a strategy using physical therapy. the purpose of the study is to confirm the comparative effectiveness of chuna therapy and physical therapy.

menstrual pain is known to be caused by increased tension in the uterine muscles and irregular contractions, and is experienced by 50% of women who menstruate. however, most people control pain with nsaids or hormones. among non-pharmacological treatments, manual therapy is known to control menstrual pain by influencing pain perception and pain-related serological factors. previous research results have shown that manual therapy using sacroiliac joint correction and high-speed, low-amplitude thrust techniques is effective for menstrual pain. however, there is still no randomized controlled study limited to chuna therapy. therefore, the investigators would like to conduct a randomized clinical study to determine the effectiveness and safety of chuna therapy for primary dysmenorrhea.

Eligibility criteria:
inclusion criteria: * patients whose menstrual pain is nrs 5 or higher during the last 3 months due to primary dysmenorrhea * patients who are between 14 and 49 years of age * patients whose cycle has been regular between 21 and 40 days for the past 3 months * patients who agree to participate in clinical research and provide written test subject consent exclusion criteria: * patients whose cause of menstrual pain is determined to be an organic problem (uterine fibroids, adenomyosis, endometriosis, etc.) rather than a primary cause. * patients who have taken oral contraceptives or other hormonal therapy within the past 3 months. * patients diagnosed with other chronic diseases (stroke, myocardial infarction, kidney disease, diabetic neuropathy, dementia, epilepsy, etc.) that may interfere with the treatment effect or interpretation of results. * patients who are currently taking steroids, immunosuppressants, drugs for mental illness, or other drugs that may affect the results of the study. * patients for whom manual therapy is inappropriate or unsafe: history of lumbar fusion or pelvic girdle surgery, spinal fracture, or severe instability. * pregnant women, those planning to become pregnant within 6 months, and those planning to take hormones such as oral contraceptives. * patients who finished participating in another clinical study less than 1 month ago, or who plan to participate in another clinical study during the study participation and follow-up period within 6 months from the date of selection. * patients who find it difficult to fill out the consent form for research participation. * other cases where participation in clinical research is deemed difficult by the researcher.

Keywords: chuna dysmenorrhea
acupuncture for pain control in the emergency department

Conditions: Neck Pain; Ankle Injuries; Headache Disorders, Primary

Summary: acupuncture is widely used for managing acute and chronic pain conditions. in the context of an emergency department (ed), patients often present with non-emergent acute pain symptoms. this may result in a delayed triage process and inefficient emergent management. an integrative patient-care approach in emergency departments has been explored that may improve patient satisfaction and promote efficient use of healthcare resources for non-emergent patients in the ed. this implies there is a potential role for acupuncture in such contexts. the aim of this pilot study is to assess the effectiveness and safety of acupuncture as an add-on intervention for patients with non-emergent acute musculoskeletal pain and primary headaches in an ed setting. hypotheses of this study are as follows: 1. a single session of add-on acupuncture, with standard ed management, can reduce pain levels in non-emergent acute pain, compared to standard ed management alone. 2. a single session of add-on acupuncture to standard ed management can reduce additional consumption of healthcare resources for management of non-emergent acute pain, compared to standard ed management alone. this study aimed to include 40 participants, 20 in the acupuncture plus standard ed management group and 20 in the standard ed management alone group.


Eligibility criteria:
inclusion criteria: * aged over 19 years with acute pain defined as pain occurring within 72 hours of ed presentation * acute neck pain with no evidence of neurological abnormality * acute headache which meets the classification criteria of a primary headache as described by the international headache society (code 1 to 4) * acute ankle injury with no evidence of fracture or complete tear of ligaments exclusion criteria: * any suspected non-musculoskeletal cause (neoplasm or neurological complications) for neck or ankle pain * any suspected secondary headaches classified by codes 5 to 12 in the international classification of headache disorders, 2nd edition * pain due to bone fracture or joint dislocation * pain with fever (defined by a temperature above 37.5 °c) * inappropriate at the ed physician's discretion * pain level of less than 4 points of pain intensity on the numerical rating scale (nrs) (range 0 to 10) at the completion of observations after the standard ed management * pregnant women

Keywords: acupuncture emergency department acute pain ankle sprain neck pain primary headache
mobility exercises for gait (meg neuroplasticity project)

Conditions: Cerebral Palsy

Summary: this study is directed at identifying a the neurophysiological changes seen in children with cerebral palsy (cp) after undergoing physical therapy. the specific aims of the study will: (1) determine the changes in the sensorimotor cortical activity after physical therapy, (2) determine the mobility, participation and muscular performance improvements after therapy, and (3) determine the changes in a child's participation in activities outside of the laboratory environment.

this study is directed at identifying a the neurophysiological changes seen in children with cerebral palsy (cp) after undergoing physical therapy. the specific aims of the study will: (1) determine the changes in the sensorimotor cortical activity after physical therapy, (2) determine the mobility, participation and muscular performance improvements after therapy, and (3) determine the changes in a child's participation in activities outside of the laboratory environment. the study consists of a cohort of children with cp that will undergo an action-perception training protocol, a cohort that will undergo a high velocity power training protocol and a cohort that will undergo body weight supported treadmill training. participants will be between the ages of 9-18 years and have gross motor function classification score levels between i-iii. all participants will complete final initial baseline measures of their brain activity, mobility, muscle performance, and participation activity outside of the laboratory. after completing these tests, the children will undergo the respective physical therapy protocols for 8-weeks (3 days a week). after the 8-weeks of therapy, both groups will repeat the same tests that were completed at baseline. follow-up assessment will consist of a physical therapist scheduling a time to visit the family at their house and ask them questions about the child's participation in activities.

Eligibility criteria:
inclusion criteria: * sustained a brain injury around the time of birth or a diagnosis of cerebral palsy * must be able walk without a wheelchair (gmfcs i-iii) exclusion criteria: * children dependent on a wheel chair for mobility * braces, permanent retainers, or metal in the head (creates artifact in the meg) * orthopedic surgery within last 6 months * botulinum injections within the last 6 months

Keywords: gait training power training action-perception training brain imaging mobility
ozonated water irrigation as an adjunct to periodontal therapy

Conditions: Periodontal Diseases

Summary: the use of chlorhexidine or ozonized water in periodontal pockets accompanying npt can provide a significant improvement in probing pocket depths compared to conventional treatment. however, the effect of subgingival ozonized water applications on vegf and igf levels, which are thought to play a role in the pathogenesis of periodontal disease and periodontal regeneration, should be examined.

background: this study aims to evaluate the effects of subgingival ozonated water irrigation as an adjunct to non-surgical periodontal treatment on clinical and biochemical parameters of patients with moderate and severe periodontitis. methods: a total of 72 stage ii and stage iii periodontitis patients were included in the study. the systemically healthy patients which were between the ages of 19 and 58 were treated non-surgically. at the end of each visit concerning periodontal treatment, the pocket of each tooth was irrigated with a sterile plastic syringe (10 ml per quadrant) with a blunt tip containing ozonated water (ow; ozone groups), 0.12% chlorhexidine digluconate (chx groups) or saline (c; control groups) for 30-60 s. periodontal clinical parameters, gingival crevicular fluid (gcf) vascular endothelial growth factor (vegf) and insulin-like growth factor-1 (igf-1) levels were evaluated at baseline and 8 weeks after periodontal treatment. all statistical data were analyzed using spss software.

Eligibility criteria:
inclusion criteria: * good general health without a history of systemic disease (hyperthyroid, diabetes, etc.) * ≥ 20 teeth * having not received periodontal treatment within the past 6 months * no contraindication for periodontal therapy and ozone application * presenting moderate-to-severe periodontitis according to criteria outlined by 2017 world workshop. exclusion criteria: * smoking * use of anti-inflammatory and antibiotic drugs within the past 6 months * pregnancy, lactation or use of oral contraceptives

Keywords: ozone periodontitis chlorhexidine digluconate root planing
diagnostic performance of deep learning for angle closure

Conditions: Angle Closure Glaucoma

Summary: primary angle closure diseases (pacd) are commonly seen in asia. in clinical practice, gonioscopy is the gold standard for angle width classification in pacd patietns. however, gonioscopy is a contact examination and needs a long learning curve. anterior segment optical coherence tomography (as-oct) is a non-contact test which can obtain three dimensional images of the anterior segment within seconds. therefore, the investigators designed the study to verify if as-oct based deep learning algorithm is able to detect the pacd subjects diagnosed by gonioscopy.


Eligibility criteria:
the inclusion criteria in the study were as follows: (1) all participants must be ≥ 18 years old; (2) study subjects had a previous diagnosis of the aca status (narrow or open, pas or non-pas) based on gonioscopy, ss-oct scans and medical history records. exclusion criteria of the data include: (1) poor compliance in receiving gonioscopy examination; (2) unclear as-oct scans due to blinking or out of focus; (3) recent use of miotics within a month; 4) secondary angle closure sue to subluxation or dislocation, uveitis, neovascular glaucoma, et al.; 5) history of ocular surgery or laser iridotomy; 6) patients who previously had an episode of primary angle closure (which was obtained on history by asking the patients).