Kornimate/medical-research-clean huggingface dataset:
vericiguat drug-drug interaction with nitroglycerin in stable coronary artery disease patients

Conditions: Coronary Artery Disease

Summary: this study is intended to investigate the effect of nitroglycerin on vericiguat in patients with stable coronary artery disease (cad). nitroglycerin is the standard therapy to treat acute crisis of angina. thus there is a high likelihood of co-administration of both drugs in the target indication of vericiguat, worsening heart failure (hf). therefore, it is important to investigate the safety and tolerability of vericiguat and nitroglycerin, which may be used as unprescribed on-demand treatment by patients with acute episodes of angina pectoris.


Eligibility criteria:
inclusion criteria: patients with stable cad defined by * coronary artery stenosis in any of the 3 main coronary vessels \> 50% documented by coronary angiography within last 36 months or history of myocardial infarction * age: 30 to 80 years * body mass index (bmi): above/equal 18.0 and below/equal 36.0 kg / m² * female subjects must be of non-childbearing potential exclusion criteria: * intervention e.g. revascularization by percutaneous coronary intervention (pci) and/or coronary artery bypass graft (cabg) during the last 3 months * progressive angina with symptoms of worsening of angina within the \< 3 months * history of recent (\< 6 months prior to the first screening examination) myocardial infarction or unstable angina * symptomatic carotid stenosis, or transient ischemic attack or stroke within 3 months prior or patients with stroke at more than 3 months prior with significant residual neurologic involvement * insulin dependent diabetes mellitus * clinically relevant cardiac ischemia * clinical significant persistent ischemia * atrial fibrillation, pacemaker, defibrillator, atrial ventricular (av)-block ii and iii * systolic blood pressure below 110 or above 160 mmhg * diastolic blood pressure above 100 mmhg * heart rate below 50 or above 100 beats / min * estimated glomerular filtration rate \< 30 ml/min/1.73m2
brain energy and cognition

Conditions: Energy Restriction; Sleep Deprivation

Summary: this proposed laboratory study will extend previous findings on relationships between cognitive function and nutritional status to conditions that more closely resemble military operations where aerobic exercise, inadequate nutritional intake and sleep deprivation combine to degrade cognitive function. the investigators will examine cognitive function, brain activity and glucose levels in volunteers who are calorie-deprived, performing high workload cognitive tests, exercising and, in one arm of the study, are sleep-deprived for approximately 48 hours. a comprehensive cognitive test battery will be repeatedly administered and several cognitive tests will be administered when volunteers are exercising. interstitial glucose levels will be assessed and whole body nitrogen utilization determined. the effects of energy restriction and the physiological basis of the relationship between peripheral glucose levels and cognitive function will be examined using a state-of-the-art imaging technology, functional magnetic resonance imaging (fmri). this technique will allow any key brain regions affected by caloric deprivation to be identified.


Eligibility criteria:
inclusion criteria: * must be active duty army stationed at natick soldier systems center * fluent in english (non-native english speakers can be enrolled); males and females aged 18 - 39 years. exclusion criteria: * not yet reached 18th birthday, metal implants - which can interfere with fmri scanning; fear of small places; pregnant (usariem will test for pregnancy), attention deficit hyperactivity disorder (adhd) - if previously documented by a waiver; acute or chronic physical limitation that would hinder performing cycle exercise; known allergies to medical adhesives.

Keywords: energy restriction sleep deprivation cognitive performance brain function
covid-19 serology and immunosenescence

Conditions: Covid19; Geriatric Medicine; Seroconversion; Immunosenescence

Summary: this study aims to determine how long covid-19 neutralizing antibodies can be detected in an elderly institutionalized population presenting fragility factors. this study also aims to stratify seroconversion by immunological profiles of the elderly patients residing in the ehpad. this stratification requires the measurement of immunological marker levels already described in immunosenescence and also involved in the development of certain chronic infectious diseases more common in the elderly population. this analysis will enable the investigators to describe an immunological, clinical and biological profile representing a patient who has developed an immunity against covid 19. it will also help the investigators to understand the different mechanisms leading to a reduced immune response after a potential administration of a vaccine. finally, it will help describe the immune profiles of elderly residents who presented with non-severe forms of covid-19.


Eligibility criteria:
inclusion criteria: * residents of the ehpad/usld st victor of the amiens chu who took part in the screening campaign (rt-pcr and serology) organized by the amiens chu * residents who signed a consent form to participate in the study exclusion criteria: * the patient or his legal representative refused to participate in the study * heavily sedated patients

Keywords: covid19 geriatric medicine seroconversion immunosenescence
factors associated with residual disease in the central cone

Conditions: Cervical Intraepithelial Neoplasia

Summary: cervical conization using the loop electrosurgical excision procedure (leep) is the standard treatment for patients with high-grade cervical intraepithelial neoplasia. several studies have shown that excising a central cone reduces the rate of positive endocervical margins. the purpose of this study is to identify clinicopathological factors associated with residual disease in the central cone and to develop a predictive model to better determine which patients may require this additional procedure.

this study pretends to create a retrospective database including all patient who underwent a loop electrosurgical excision procedure by treatment for high-grade cervical intraepithelial neoplasia and create a a predictive model for top-hat resection in patients with high grade cin

Eligibility criteria:
inclusion criteria: * patients who underwent a loop electrosurgical excision procedure (leep) exclusion criteria: * a diagnosis of micro-invasion or nonsquamous histology * less than six months of follow-up * incomplete information in their clinical charts.

Keywords: residual disease central cone predictive model
maternal probiotic supplementation for improved outcomes in infants of diabetic mothers

Conditions: Infant of Diabetic Mother

Summary: the purpose of this study is to test the hypothesis that maternal probiotic supplementation is associated with infant gut microbiome variation and improved neurodevelopmental outcomes as measured by erp performance in infants of diabetic mothers (idms), a cohort that is at-risk for recognition memory abnormalities.


Eligibility criteria:
inclusion criteria: * pregnant people in their second or third trimester with a diagnosis of gestational diabetes. * bmi 18.5-45 kg/m2 at first prenatal visit * age 21-45 at time of delivery * report social support for and intention to exclusively breastfeed for at least 3 months * singleton pregnancy exclusion criteria: * alcohol consumption \>1 drink per week during pregnancy/lactation * tobacco consumption during pregnancy/lactation * inability to speak/understand english * known congenital metabolic, endocrine disease (other than gdm), or congenital illness affecting infant feeding * history of type i diabetes * birthing parent currently taking over the counter probiotic preparation

Keywords: infant of diabetic mother probiotic gut microbiome neurodevelopment
the effect of mandala coloring activity on test anxiety

Conditions: Educational Problems; Anxiety; Test Anxiety; Mental Health

Summary: this study aims to investigate the effect of mandala coloring activity on test anxiety of nursing students.

university life poses various challenges for students, such as being away from family, financial difficulties, and exam anxiety, which can increase stress levels. test anxiety, a form of situation-specific anxiety, negatively impacts students' academic performance and well-being by reducing concentration and learning efficiency. the combination of theoretical and clinical demands in nursing education further amplifies stress, making it a particularly challenging field for students. this study is a randomized controlled experimental research conducted between december 2, 2024, and january 13, 2025. the study population consists of nursing students enrolled in the mental health and psychiatric nursing course at a private university during the 2024-2025 academic year. based on sample size calculations conducted using the g\*power program, considering similar studies and measurement methods, it was determined that 26 students per group are required. accounting for potential data loss, it is planned to conduct the study with a total of 62 students, 32 in each group. students will be informed about the research, and those who voluntarily agree to participate will complete a "demographic characteristics form" and a pre-test using the "test anxiety inventory." subsequently, students will be randomly assigned to the intervention and control groups in a 1:1 ratio using a random numbers table, with 31 students in each group. students in the intervention group will be provided with mandala templates and coloring materials. they will be asked to color for 15 minutes twice a week over a two-month period. email reminders will be sent to the students about the coloring sessions, and they will submit their completed mandalas to the researchers every friday. students who fail to complete two consecutive coloring sessions will be excluded from the study. thirty minutes before the exam, the "test anxiety inventory" will be applied as a post-test, and the study will be concluded. the data obtained will be subjected to statistical analysis, and the process of writing the manuscript will follow.

Eligibility criteria:
inclusion criteria: * being a student enrolled in the mental health and psychiatric nursing course at the selected private university. * proficiency in the turkish language. * having no physical disability that would hinder coloring activities. * willingness to participate voluntarily. exclusion criteria: * students with psychological diagnoses such as anxiety or depression. * students who do not fully complete the questionnaire/survey forms. * students who neglect mandala coloring for two consecutive sessions.

Keywords: test anxiety nursing education mandala coloring randomized controlled trial
study of the safety and effectiveness of rabeprazole in treatment of helicobacter pylori infection in adults.

Conditions: Helicobacter Infections; Bacterial Infections

Summary: the purpose of the study is to confirm the safety and effectiveness of rabeprazole in the treatment of adult patients with helicobacter pylori (h. pylori) infection in routine clinical practice.

an infection of helicobacter pylori (h. pylori) is a risk factor for many types of gastrointestinal diseases and associated with stomach inflammation, ulcer of the stomach or small intestine. the recommended treatment for the infection is a triple therapy consisted of one proton pump inhibitor, such as rabeprazole, and two antibiotics administered for 7 days. this is an open label, nonrandomized study of the safety of rabeprazole in the treatment of patients with h. pylori infection. the study consists of 2 phases: the 2-month main phase and the 4-month monitoring phase (total duration of 6 months). during the main phase, patients are treated for 7 days with three drugs (rabeprazole, clarithromycin, and amoxycillin), and the effectiveness of the treatment is assessed 4 weeks later. during the monitoring phase, patients are interviewed at monthly intervals to assess symptoms and to report any adverse events. safety assessments include the incidence of adverse events throughout the treatment and monitoring phases, and laboratory tests (hematology, biochemistry, urinalysis) and vital signs at the start of the study and after 1 month. assessments of effectiveness include the eradication of h. pylori infection, assessed by the urea breath test one month after treatment. the primary study hypothesis is that rabeprazole is well-tolerated long-term in the treatment of patients with h. pylori infection in routine clinical practice. rabeprazole tablets (20 milligrams\[mg\]) taken orally twice daily for 7 days. clarithromycin (500mg) and amoxycillin (1 gram) taken twice daily for 7 days.

Eligibility criteria:
inclusion criteria: * patients diagnosed with helicobacter pylori (h. pylori) infection * patients over 45 years of age must have an endoscopic examination of the digestive system * patients must have positive result of urea breath test (ubt) for h. pylori * patients being treated with rabeprazole in combination with clarithromycin and amoxycillin to eradicate h. pylori. exclusion criteria: * known hypersensitivity to rabeprazole, clarithromycin, or amoxycillin * evidence from endoscopic examination of gastrointestinal hemorrhage or stomach cancer, or had previous stomach surgery * use of aspirin, non-steroidal anti-inflammatory drugs (nsaids), antibiotics, bismuth, or proton pump inhibitors during the last 4 weeks prior to study initiation * history of successful treatment to eradicate h.pylori infection * females who are pregnant or nursing

Keywords: rabeprazole proton pump inhibitor helicobacter infections helicobacter pylori h pylori bacterial infections
comparison of menstrual function among sprinters, long marathon runners, and non-athletic females

Conditions: Menstruation Disturbances

Summary: the purpose of this study is to compare between sprinters and long marathon in menstrual characteristics and serum estradiol level.

menstrual function and dysfunction conversations have long been stigmatized both in the general population and in sport settings (o'flynn, 2006). however, discussions of menstruation in the sport context often focuses on the impact of physical menstrual symptoms and dysfunction on activities such as training and sport performance (bruinvels et al., 2016; knowles et al., 2019). in addition, no study had been compare between sprinters and long-marathon runners in menstrual characteristics and estradiol level. therefore, the purpose of this study to compare between sprinters and long marathon in menstrual characteristics and serum estradiol level.

Eligibility criteria:
inclusion criteria: * virginal females. * their age ranged from 16 to 19years. * all females had the same socio-economic status. for athletic groups only: * they have been starting the practice of sport at least one year before the onset of menarche. exclusion criteria: * females who had been used oral contraceptives or any hormonal treatment in the previous six months. * smoking. * history of chronic disease. * having any psychiatric problems. for athletic groups only: * injured females who were absent from training for at least three months.

Keywords: menstrual function serum estradiol levels sprinters long marathon runners non-athletic females
prospective registry and biobank for long-term observational studies in adult patients with pulmonary hypertension

Conditions: Pulmonary Hypertension

Summary: prospective registry and biobank for long-term observational studies in adult patients with pulmonary hypertension

in a prospective registry prevalent and incident patients diagnosed with group 1 to 5 pulmonary hypertension will be enrolled. in an integrated biobank body fluid samples will be collected at enrollment and sequentially during treatment with targeted drugs for pulmonary hypertension.

Eligibility criteria:
inclusion criteria: * diagnosis of pulmonary hypertension group 1 to 5 * ability to give informed consent exclusion criteria: - withdrawal of informed consent
trial comparing relapse rates between standard ureteroscopic removal of ureteral stone and standard removal with additional ureterorenic clearing of non-symptomatic stones in the kidney

Conditions: Ureteral Stones, Kidney Stones

Summary: patients with a ureteral or kidney stone that causes symptoms, like pain, frequently have small kidney stones that don't cause symptoms. if these small kidney stones are determined to be asymptomatic (not causing any problems or pain), then most urologists will simply remove the symptomatic ureteral stone and leave the additional stones in the kidneys. however, symptomatic kidney stones started as small stones that didn't cause symptoms. this means that the small stones remaining in the patient's kidney may cause problems later. the purpose of our research is to test if removing small stones from the kidney prevents future stone episodes.


Eligibility criteria:
inclusion criteria: * scheduled to undergo surgery (urs or pcnl) for a primary stone. * computed tomography (ct) exam within the 90-day pre-operative period * small (≤ 6mm) asymptomatic stones in visible on kub or ct (i.e., calcium stones) in the contralateral kidney for a primary renal stone or ipsilateral kidney for primary ureteral stone. * recurrent (having had previous stones) or multiple (simultaneous bilateral stones) stones * able to give informed consent * age 21 years or older exclusion criteria: * inability to give informed consent * age less than 21 years * stones not visible on kub or ct * patients with systemic disease or renal anatomical disorders (rta, primary hyperparathyroidism, sarcoidosis, enteric hyperoxaluria, medullary sponge kidney) * any condition (eg, psychiatric illness) or situation that, in the investigator's opinion, could put the * subject at significant risk, confound the study results, or interfere significantly with the subject's * participation in the study. * unwilling to participate.

Keywords: kidney stone
efficacy test of real-time upper gastrointestinal monitoring system

Conditions: Upper Gastrointestinal Bleeding

Summary: a monitoring system was developed for detecting upper gastrointestinal (ugi) rebleeding. this system consists of (1) a tiny endoscopy, (2) a wearable device, and (3) a software. the endoscopy is inserted to ugi tract via nasal cavity and then stayed there for 3 days. the wearable device is set to regularly receive the pictures from the endoscopy and sent to the software, which is able to automatically analyze whether the rebleeding occurs. this study aims to test the feasibility and efficacy of the monitoring system.


Eligibility criteria:
inclusion criteria: * "rockall" score ≧3 exclusion criteria: * pregnant woman; * behavioral disorder; * major cognitive-perceptual deficit; * the person who has a nasogastric (ng) tube; * other deficits or disorders that are not suitable for ng insertion; * participants who need to take mri scan.
mood lifters online for graduate students and young professionals

Conditions: Depression; Anxiety Disorders; Mood Disorders; Mental Illness; Stress

Summary: mood lifters is a revolutionary mental wellness program that teaches scientifically validated strategies in a supportive group setting. this study will test two new versions of the program designed specifically for graduate students and young professionals. participants will need to attend 12 hour long virtual weekly meetings on zoom that focus on helpful mental health strategies and skills. participants will be encourage to practice what the participants learn at home in order to improve their mood or mental wellness. additionally, participants will complete a series of measures (approx. 1-1.5 hours) prior to, at the end of the program, 1 month after the program and 6 months after the program.


Eligibility criteria:
inclusion criteria: * participants ages 22-32 (must identify as either a graduate student or a young professional) exclusion criteria: * active suicidality, mania, or psychosis
a trial of enteral colostrum on clinical outcomes in critically ill patients

Conditions: Critical Illness; Infection Complication; Multiple Organ Dysfunction Syndrome

Summary: enteral administration of immune-modulating nutrients such as glutamine, omega-3 fatty acids, selenium, and antioxidants has been suggested to reduce infections and improve recovery from critical illness. however, the effects of colostrum on clinical outcomes in critical ill patients has not been investigated. in current trial, intensive care unit patients with enteral feeding will receive either enteral colostrum or maltodextrin as placebo.

a randomized, double blind, controlled trial will be conducted in general intensive care unit (icu) in tehran, iran. after a full review of the inclusion and exclusion criteria and explanation of the risks and benefits of the study, written consent form will be completed. intervention patients will be received 20 g/day of colostrum along with enteral formula and control patients will be received maltodextrin along with enteral formula. patients will be assessed for occurrence of new infection, organ failure, duration of stay in icu, 28 days and 6 months mortality and inflammatory and immune markers.

Eligibility criteria:
inclusion criteria: * adult patients (\>18 years old) admitted to icu * start of study intervention within 48 hours after icu admission * expected to require enteral nutrition for at least 72 hours aiming for full enteral nutrition and receive at least 80 percent of enteral formula during the first 48 hour * written informed consent of patient or written informed consent of legal representative exclusion criteria: * enrollment in a related icu interventional study * requiring other specific enteral nutrition for medical reason * death or discharge before 5th day * having any contra-indication to receive enteral nutrition * pregnant patients or lactating with the intent to breastfeed * bmi \ 40.0 kg/m2 * have life expectancy of \<6 mo * patients who are moribund * history of allergy or intolerance to the study product components * receiving colostrum during two weeks before start study product * have other reasons

Keywords: colostrum critical care outcomes intensive care unit inflammation infection mortality
a prospective open-label extension study of gaboxadol in primary insomnia

Conditions: Primary Insomnia

Summary: to evaluate the safety and tolerability of gaboxadol in primary insomnia

to evaluate long-term safety of gaboxadol in healthy adults.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of primary insomnia

Keywords: primary insomnia