Kornimate/medical-research-clean huggingface dataset:
does a peer navigator improve quality of life at diagnosis for women with breast cancer?

Conditions: Breast Cancer

Summary: women indicate the greatest needs for counseling at the time of initial diagnosis for primary breast cancer. the time of initial diagnosis is also often the time of greatest need for information for women and their families. however, this is the time when a woman, overwhelmed by shock and trauma, is least likely to absorb information provided or seek new sources of information. an informed peer navigator with carefully trained communication skills can judge the level of information to disclose and pace that information in a way that can be easily absorbed and understood. she will also provide support. womencare, a well-established santa cruz agency providing free support services for women with cancer, and the psychosocial treatment lab at stanford therefore ask whether women newly diagnosed with breast cancer will improve their quality of life by participating in a peer navigator program. womencare's peer navigators provide emotional support, good listening skills, and information on resources for women just diagnosed with breast cancer. having a peer counselor while a woman goes through treatment may reduce the magnitude of distress or shorten its time course. it may also reduce distress in family members, and improve relationships with medical personnel. this study is designed to evaluate the effectiveness of a peer navigator program where a woman newly diagnosed with breast cancer is carefully matched for 3 to 6 months after diagnosis with a trained volunteer who is herself a breast cancer survivor. navigators and sojourners (newly diagnosed women) are matched on things that are important to them. women often want to be matched on the type of surgery or treatment they have received. we assign half of the women (by a process similar to a coin toss) to our peer navigator program and half to a group that receives standard medical care but no peer navigator. in this way we can compare the groups to see whether those matched with a peer navigator have better quality of life over the 3 to 6 month period. all women who join our study, regardless of the group to which they are assigned, get an extra consultation with a nurse specialist at a local hospital. in this consultation, the nurse reviews the cancer resources available to the woman in santa cruz county. this meeting is tailored to the woman's individual diagnosis and situation.


Eligibility criteria:
inclusion criteria: women within 2 months of diagnosis of breast cancer can read english within the catchment area of watsonville and santa cruz california - exclusion criteria: women who have previously had a peer navigator intervention women who have a chronic history of hospitalization for psychiatric reason -
study of drug combination on pharmacokinetics in healthy volunteers

Conditions: Hepatitis C Infection

Summary: the purpose of this study is to assess the effect of daclatasvir, asunaprevir, and bms-791325 on the pharmacokinetics of selective serotonin reuptake inhibitors.


Eligibility criteria:
inclusion criteria: 1. signed informed consent form a) signed written informed consent must be obtained from the subjects in accordance with requirements of the study center's irb or iec before the initiation of any protocol-required procedures. 2. target population a) healthy subjects as determined by no clinically significant deviation from normal in medical history, psychiatric history, physical examination findings, vital sign measurements, 12-lead ecg measurements, physical measurements, and clinical laboratory test results. 3. age and reproductive status 1. males and females, ages 25 to 55 years, inclusive. 2. women of childbearing potential (wocbp) must have a negative serum pregnancy test (minimum sensitivity 25 iu/l or equivalent units of hcg) within 24 hours prior to the start of study drug. 3. women must not be breastfeeding. exclusion criteria: 1. any significant acute or chronic medical illness. 2. current or recent (within 3 months of study drug administration) gastrointestinal disease that could impact upon the absorption of study drug (appendectomies with no complications are allowed at the investigator's discretion). 3. any major surgery within 4 weeks of study drug administration. 4. smokers (those who currently smoke, as well as those who have stopped smoking less than 6 months prior to the start of study drug administration). 5. any other sound medical, psychiatric, and/or social reason as determined by the investigator.
the effect of percussion massage therapy on the recovery of doms in physically active young men delayed onset muscle soreness = doms

Conditions: Delayed Onset Muscle Soreness (DOMS)

Summary: the goal of this clinical trial is to learn the effect of percussion massage therapy (pmt) on the recovery of delayed onset muscle soreness (doms) in physically active young men. the main question it aims to answer is: compared with static stretching, do 25 minutes and 40 minutes of pmt can decrease pain and increase the rang of motion of knee of low limb doms in physically active young men? compared with static stretching, do 25 minutes and 40 minutes of pmt sessions can increase power and improve the neuromuscular electrophysiology of low limb doms in physically active young men? researchers will compare 25 minutes and 40 minutes of pmt to a static stretching to see if different times of pmt are better to treat doms. participants will： undergo squats to induce low limb doms. receive static stretching, 25 minutes and 40 minutes of pmt, respectively for three times. visit the lab for four times in one week for tests.


Eligibility criteria:
inclusion criteria: regularly participate in physical activity, have no contraindications to exercise, and volunteered to participate in this study exclusion criteria: participants consumed alcohol and exercised vigorously throughout the formal experiment or they underwent interventions other than those planned for the experiment.

Keywords: delayed onset muscle soreness percussion massage therapy stretching recovery
treatment of fever in the emergency department

Conditions: Fever

Summary: fever is a frequent cause of admission to the emergency department (ed) around the world. while it can be caused by a wide range of conditions, the most effective treatment based on its etiology is still undetermined. this observational, prospective, single-center study enrolled adult patients who accessed the ed for fever, with the aim to define the most effective treatment for them.

physicians were free to administer paracetamol 1000 mg (p), the combination paracetamol 500 mg/ibuprofen 150 mg (pi) or ibuprofen 600 mg (i).the primary endpoint was both 1-degree and 1-point reduction in body temperature for all associated symptoms on the numeric rating scale (nrs) after 1 hour (t1). secondary endpoint was the reduction of at least 2 points on the nrs after two hours (t2). adverse events, the needing of a rescue therapy and the response based on the underlying etiology (bacterial, viral, or immune/neoplastic) were also evaluated.

Eligibility criteria:
inclusion criteria: * fever with/without associated symptoms * adults who had given their consent to participate in the study. exclusion criteria: * age \< 18 years old * contraindications or allergies to paracetamol, ibuprofen or to the combination paracetamol/ibuprofen * patients unable to take oral drugs * patients who did not express their consent to participate to the study

Keywords: fever paracetamol paracetamol/ibuprofen emergency department
dha supplementation in patients with stgd3

Conditions: Dominantly Inherited Stargardt's Disease (STGD3)

Summary: we have found that biomarkers of long-term elevated dietary intake of omega-3 fatty acids such as dha and epa are inversely associated with severity of disease phenotype in stgd3 patients. therefore, the purpose of this study is to follow stgd3 patients as they supplement their diets with dha/epa.


Eligibility criteria:
inclusion criteria: * all moran eye center patients with stgd3 exclusion criteria: * all others
opioid-potentiated volative anaesthetic vs. remifentanil and propofol during abdominal aortic aneurysm surgery

Conditions: Aortic Diseases; Abdominal; Aneurysm; Surgery

Summary: comparing 2 different anaesthetic methods during abdominal aortic aneurysm surgery. the patients will be followed up 30 days postoperative. number of patients included will be 200. perioperative details will be analyzed.


Eligibility criteria:
inclusion criteria: * patients who are planned for open, elective abdominal aortic aneurysm surgery. * asa group 1-4. exclusion criteria: * patients below 18 years. * patients who are included in other pharmaceutical studies. * opioids-, benzodiazepins-, antiepileptic drugs-, alcohol- and α2-agonists abuse. * pregnant and breastfeeding women. * patients with familiar history of malignant hyperthermia. * patients with known hypersensitivity for opioids, propofol or volative anaesthetics. * patients with considerable arrythmia (atrial fibrillation /atrial flutter is acceptable). uncontrolled hypertension, serious psychiatric disease. * patients with unstable angina pectoris or myocardial infarction last month before inclusion. * acute abdominal aortic surgery. acute dissection or rupture. * planned laparoscopic abdominal aortic aneurysm surgery.

Keywords: propofol anaesthesia sevoflurane abdominal aortic aneurysm
effects of sterile kinesio tape on anterior cruciate ligament reconstruction

Conditions: Postoperative Pain; Edema

Summary: anterior cruciate ligament reconstruction (aclr) is a surgical tissue graft replacement of the anterior cruciate ligament, located in the knee, to restore its function after an injury. aclr is used as the gold standard in coping with pain, deformity, and instability for the patients. the most important factors affecting the success of both surgery and postoperative rehabilitation programs are edema, joint movement limitation and pain around the knee in the early postoperative period. if these parameters are managed well in the postoperative period, the quality of life of the patient increases much earlier. in this respect, kinesio taping treatment, which is practical, comfortable, and safe for the patient, is one of the complementary treatment modalities with positive clinical results. no researchers have studied the effects of sterile kinesio tape applied during acl reconstruction on edema, pain and range of motion in immediate care postoperatively. the purpose of our study i̇s to assess effects of sterile kinesio tape application on postoperative edema, pain and range of motion after aclr within 72 hours. thirty-seven patients who have undergone aclr will be recruited to our study. patients will be randomized into 2 groups; group 1: sterile kinesio tape application, group 2: control group. all patients will be assessed for pain intensity (with visual analog scale-vas), edema (with tape measurement) and range of motion (with goniometric measurement-knee flexion/extension). assessments will be done every day for 3 days (a total of 3 measurements). group 1 will receive sterile kinesio taping application within 72 hours applied with sterile web cut kinesio tape without tension additional to standard during aclr postoperative care. group 2 will receive only standard postoperative care.


Eligibility criteria:
inclusion criteria: * patients who underwent anterior cruciate ligament reconstruction exclusion criteria: * with soft tissue or bone problems affecting the hip or ankle * who any neurologic problems, * who had any systematic rheumatic problems, * had scoliosis, * who had undergone orthopedic surgery before, * who were obese (bmi\> 30 kg/m2)

Keywords: kinesiotape anterior cruciate ligament reconstruction edema pain range of motion
novel retinal imaging biomarkers in early alzheimer's disease

Conditions: Mild Cognitive Impairment; Mild to Moderate Cognitive Impairment

Summary: the goal of this study is to create new retinal imaging processing software useful for the development of novel retinal biomarkers of cognitive impairment associated with alzheimer's disease (ad).


Eligibility criteria:
inclusion criteria: 1. result of the standard neuropsychological assessment 2. are men or postmenopausal women, at least 55 years of age. postmenopausal women are defined as women who have had a hysterectomy and/or bilateral oophorectomy; or who have been amenorrheic for at least 2 years; 3. fluency in english 4. participants in mild cognitive impairment (mci)/prodromal and mild-to-moderate dementia groups must assign a surrogate for purposes of informed consent and help with protocol compliance. exclusion criteria: 1. known or suspected diagnosis of non-ad, associated dementia; 2. major ophthalmologic comorbidities: ruptured globe, retinal vascular occlusive disease, retinal artery occlusion, anterior ischemic optic neuropathy, media opacification due to corneal abnormalities or cataract that prevent ocular and oct examination, glaucoma, wet (neovascular) age-related macular degeneration, history of intravitreal injections, and macular edema. if two eyes satisfy the inclusion criteria, both eyes will be included in the study.

Keywords: mild cognitive impairment mild to moderate cognitive impairment
research study investigating study medicine (nnc9204-1177) for weight management in people with overweight or obesity

Conditions: Metabolism and Nutrition Disorder; Obesity

Summary: this study looks at a new study medicine for weight management in people with overweight or obesity. the aim of this study is to find out how safe and tolerable the study medicine is. the study also looks at how the study medicine behaves in the body and how it is removed from the body. participants will either get nnc9204-1177 (the new study medicine) or placebo (a formula that looks like the study medicine but does not have active ingredients). which treatment participants get will be decided by chance. nnc9204-1177 has not been approved by the united states food and drug administration. its use in this study is experimental. participants will get 1 or more injections into the skin of the stomach area once each week for 12 weeks. the study will last for about 5 months. participants will have 19 clinic visits with the study doctor. at certain times during the study, participants will have blood draws and 3 different kinds of electrocardiograms. participants will answer mental health questionnaires. women: women cannot take part if pregnant, breast-feeding or plan to become pregnant during the study period.


Eligibility criteria:
inclusion criteria: * male or female, aged 18-55 years (both inclusive) at the time of signing informed consent * body mass index (bmi) between 27.0 and 39.9 kg/m2 (both inclusive) at screening. overweight should be due to excess adipose tissue, as judged by the investigator exclusion criteria: * any disorder which in the investigator's opinion might jeopardise subject's safety, evaluation of results, or compliance with the protocol * subjects, aged at least 40 years, with an estimated 10-year atherosclerotic cardiovascular disease (ascvd) risk greater than or equal to 5% * male subjects who are not sexually abstinent or surgically sterilised (vasectomy) and are sexually active with female partner(s) who are not using a highly effective method of contraception (such as condom with spermicide) combined with a highly effective method of contraception for their non-pregnant female partner(s) (pearl index below 1%, such as implants, injectables, oral contraceptives, intrauterine devices, diaphragm or cervical cap+spermicide), or who intend to donate sperm in the period from screening until 3 months following last administration of the investigational medical product * female subjects who are of child bearing potential (pre-menopausal and not surgically sterilised) and are sexually active with male partner(s) who are not surgically sterilised (vasectomy) and who are not using highly effective contraceptive methods (pearl index below 1%, such as implants, injectables, oral contraceptives, intrauterine devices, diaphragm or cervical cap+spermicide) combined with a highly effective method of contraception for their male partner(s) (e.g. condom with spermicide), or who are pregnant, breast-feeding or intend to become pregnant
annual study to investigate influenza vaccine due to new virus strains for the 2007/2008 influenza season in europe

Conditions: Healthy Volunteers

Summary: influenza (flu) viruses change continuously, therefore also the parts of viruses used in influenza vaccines can vary from year to year. in europe, manufacturers/marketing holders of these vaccines are required to be involved in ongoing clinical trials and to present the results to the competent authorities each year. the current study is a phase iiia clinical trial with a commercially available vaccine (influvac®) supplied in pre filled syringes. it is part of the ongoing clinical trial program for influvac® and will be done to assess the immunogenicity and safety and tolerability of next season's trivalent influenza subunit vaccine in two groups of healthy subjects: subjects aged \>= 18 and \ = 61 years of age (elderly).


Eligibility criteria:
inclusion criteria: * signed and dated informed consent. * healthy and aged \>= 18 and \ = 61 years of age. * mental health good enough to understand the study and the informed consent form and to fill in the questionnaire. exclusion criteria: * known to be allergic to eggs, chicken protein, gentamicin or any other constituent of the vaccine. * having fever and/or presenting with an acute infectious episode of the upper and/or lower respiratory airways. * having experienced a serious systemic and/or local reaction after previous influenza vaccination. * having an auto-immune disorder (e.g. ra, sle, auto-immune thyroid disorders) or other disorders affecting the immune system, taking immunosuppressive medication (such as systemic corticosteroids) including the four weeks preceding the start of the study (date of informed consent), or having a disease in a terminal stage. * having received vaccination against influenza within the previous six months before visit 1.

Keywords: influenza vaccine chmp criteria
multi-tasking to hyper-tasking: investigating the impact of next generation 911

Conditions: Stress, Psychological

Summary: emergency call centers across the country are preparing for the next generation 911 (ng911) initiative, which will allow citizens to place 9-1-1 "calls" using digital technologies such as text messaging, email, skype or instant messaging, and will expand emergency information sources to also include streaming video, photo uploads, and automatic crash notifications. the impact of these new information and communication technologies on those tasked with using them in time-sensitive emergency situations is unknown. our study is designed to address the following hypotheses: 1) we hypothesize that ng911 implementation will have a significant effect on telecommunicator stress levels and 2) a resiliency training tailored to the needs of telecommunicators will mitigate the impact on ng911 implementation on stress levels. we will test these hypotheses through the following specific aims: aim 1: measure levels of stress, job satisfaction and job performance among 9-1-1 telecommunicators before and after the ng911 implementation. aim 2: develop and test the efficacy of an evidence-based resiliency training and worker support intervention to improve psychological well-being and job performance of 9-1-1 telecommunicators. aim 3: build an abm tool of 9-1-1 call centers to improve 9-1-1 telecommunicator workforce training and smooth transitions to future call center innovations.


Eligibility criteria:
inclusion criteria: * subjects must be 9-1-1 telecommunicators (call receivers and dispatchers) who work at participating call centers and consent to participate. exclusion criteria: * we will exclude subjects who do not consent to participate * we will exclude subjects who do not confirm that they are 21 or older.
tight glycemic control in critical care patients

Conditions: Critical Illness; Hyperglycemia; Insulin Resistance

Summary: the purpose of this study is to evaluate the impact of tight control of serum glucose levels with an intensive insulin treatment in patients hospitalized in an intensive care unit with medical and surgical patients.

reduction of morbidity-mortality in critical care patients with tight glycemic control had been proven in surgical patients only. study hypothesis: in critical care patients, medical or surgical, a glucose serum level between 80 - 110 mg/dl means a lower mortality than patients with glucose levels of more than 110 mg/dl.

Eligibility criteria:
inclusion criteria: * 15 years of age or older, * probability of staying in critical care for more than 48 hours, * agreement with the informed consent. exclusion criteria: * pregnancy, * participating in other trials, * diabetic keto-acidosis or diabetic hyperosmolar state, * moribund * do-not-resuscitate orders, * reentry to the critical care unit of the same patient.

Keywords: critical illness critical care hyperglycemia intensive care intensive care units insulin resistance intensive insulin therapy conventional insulin therapy