Kornimate/medical-research-clean huggingface dataset:
antenatal diagnosis of coarctations of the aorta.

Conditions: Coarctation of Aorta

Summary: prenatal diagnosis of coarctation is difficult because the ductus arteriosus masks the isthmus narrowing. the problem lies in the fact that it is difficult to assert in utero diagnosis and to predict severity of neonatal symptomatology. however, it is essential to try to establish the diagnosis since it has been shown that the prenatal diagnosis improves survival and reduces morbidity.


Eligibility criteria:
inclusion criteria: * pregnant or having given birth in the last 12 months in one of the participating centers * have had an ultrasound screening in the 2nd or 3rd trimester * addressed or being addressed to the pluridisciplinary center for prenatal diagnosis for suspected coarctation of isolated aorta in front of: ventricular asymmetry at the aegis of the left ventricle or the large vessels at the aorta, discovered during a screening ultrasound second or third quarter. * be able to understand and follow the ins and outs of the study * have been informed of the study and have not objected to it exclusion criteria: * associated complex cardiac disease (transposition of large vessels, atrioventricular duct, right ventricle with double outlet) with the exception of inter ventricular communications * left ventricular hypoplasia * suspicion of interruption of the aortic arch
comprehensive lifestyle modification for patients with hypertension and metabolic syndrome: a multicenter randomized controlled trial

Conditions: Hypertension; Metabolic Syndrome

Summary: different forms of diet, e.g. mediterranean diet, dash diet, or fasting, have demonstrated efficacy in reducing elevated blood pressure. moreover, mediterranean diet, and fasting seem to be effective in improving insulin sensitivity in type 2 diabetes. further, studies on meditation or mindfulness-based interventions have shown positive effects in patients with hypertension and/or type 2 diabetes. comprehensive lifestyle modification, this is a combination of diet, exercise, and stress management, have improved coronary atherosclerosis. however, no studies have yet investigated the effects of comprehensive lifestyle modification in patients with metabolic syndrome and/or in combination with fasting therapy. this study is supported by a grant from the corona-foundation, germany.


Eligibility criteria:
inclusion criteria: * hypertension or antihypertensive medication or subclinical atherosclerosis * metabolic syndrome * basic mobility exclusion criteria: * diabetes type 1 * insulin bolus therapy * coronary artery disease * myocardial infarct, pulmonary embolism, or stroke within the past 3 months * heart failure * peripheral vascular disease * chronic kidney disease * eating disorder * dementia * other severe internal disease
measuring aided language development

Conditions: Down Syndrome; Cerebral Palsy; Apraxia of Speech; Speech Sound Disorder; Speech Disorders in Children; Speech and Language Disorder

Summary: the focus of the current study is to systematically investigate the psychometric properties of a range of aided language measures, which are based on the graphic symbol utterance and sentence development framework (binger \& kent-walsh).

our central hypotheses are: (1) psychometrically sound measures can be established to capture growth within and across different dimensions of language acquisition, and (2) some elicitation contexts will be better than others at capturing aided language growth. specific aim 1 identifies valid measures to characterize aided language progress. aim 1a uses existing data to document the psychometric properties of a range of aided language measures for preschoolers at the early stages of aided communication acquisition who have received 4 months of aided language intervention. aim 1b analyzes language progression for high-performing aided communicators who will receive 24 months of intervention; this allows for investigation across all phases of early aided language acquisition. specific aim 2 identifies elicitation contexts that demonstrate the most productive aided language use. achievement of the aims will result in measures that demonstrate strong reliability, differentiate growth for different populations, describe different dimensions of language growth, and are clinically feasible.

Eligibility criteria:
inclusion criteria: * clinical identification of down syndrome or cerebral palsy + significant speech impairment * must speak english as a primary language * must be able to express at least 25 words (using any communication mode) * must be able to accurately select picture symbols on ipad communication app with at least 50% accuracy * vision and hearing within functional limits or corrected to be within functional limits for study activities exclusion criteria: * clinical diagnosis of autism or social communication disorder * primary language spoken is a language other than english

Keywords: augmentative and alternative communication complex communication needs assistive technology aac
quality of life for subjects receiving androgen deprivation therapy and have a doubling in psa of either less than or greater than 1 year

Conditions: Prostate Cancer

Summary: the purpose of this study is to evaluate if there is a difference in quality of life (as measured by fact-p) in patients treated with androgen deprivation therapy (adt) for biochemical failure (psa recurrence) following surgery or radiation for prostate cancer depending on when adt is initiated.


Eligibility criteria:
inclusion criteria: * 18 years or older * received therapy of curative intent (surgery or radiotherapy) * have a rising psa which has doubled from a nadir value. * histologically proven prostate cancer requiring androgen deprivation therapy for at least 12 months * written informed consent to participate in the trial. exclusion criteria: * known hypersensitivity to zoladex, casodex, ar any component of these products * prior treatment with lhrh agonist or anti-androgens in the past 12 months * any concomitant condition that would make it undesirable, in the physician's opinion, for the subject to participate in the trial or would jeopardize compliance with the protocol.

Keywords: quality of life androgen deprivation therapy goserelin
clinical evaluation of systane® ultra compared to optive® in ocular surface staining

Conditions: Dry Eye Syndrome

Summary: the purpose of this study is to compare systane® ultra lubricant eye drops to optive® lubricating eye drops for ocular surface staining within dry eye subjects and to evaluate the safety of systane® ultra after 3 months of use.

following a 2-week washout phase with saline eye drops, subjects were randomized to receive either systane® ultra or optive® for the remainder of the study.

Eligibility criteria:
inclusion criteria: * willing and able to attend all study visits. * diagnosis of dry eye, as specified in protocol. * uses artificial tears, as specified in protocol. * other protocol-defined inclusion criteria may apply. exclusion criteria: * poor visual acuity, as specified in protocol. * women of childbearing potential who are pregnant, lactating, or not using adequate birth control, as specified in protocol. * any hypersensitivity or allergy to the investigational products or ingredients. * any eye disorder, ocular surgery, medication, medical condition, or systemic disease, as specified in protocol. * contact lens use within 2 weeks of screening visit. * other protocol-defined exclusion criteria may apply.

Keywords: dry eye syndrome systane ultra optive ocular surface staining osdi eye drops
emotional processing intervention for children with tbi

Conditions: Traumatic Brain Injury

Summary: investigating an emotional processing program, that is modified for use with children, is effective for children with a traumatic brain injury (tbi).

the first stage of this project will evaluate the appropriateness of an emotional processing intervention modified for a pediatric population. the researchers will modify the intervention prior to the evaluation by the 15 typically developing children. the second stage of the project will evaluate the effectiveness of an emotional processing intervention to improve performance on tests of emotional processing in individuals with tbi. emotional processing includes both facial affect recognition and social perception measures.

Eligibility criteria:
inclusion criteria: ages of 9 and 17. speak and read english fluently. healthy volunteer or have sustained a tbi at least 1 year ago, that has affected his or her ability to process emotions. exclusion criteria: previous stroke, ms, or neurological injury or disease in the past (like brain tumor or epilepsy) other than tbi. history of significant psychiatric illness (like bipolar disorder, schizophrenia or psychosis). uncontrolled seizures or other unstable medical complications.

Keywords: emotional processing pediatric traumatic brain injury
effect of remote ischemic preconditioning on cognitive function after off-pump coronary artery bypass graft

Conditions: Ischemic Heart Disease

Summary: the aim of this study is to evaluate the effects of remote ischemic preconditioning on cognitive function in patients undergoing off-pump coronary artery bypass graft.


Eligibility criteria:
inclusion criteria: * patients undergoing elective off-pump coronary artery bypass graft surgery exclusion criteria: * emergency operation * preoperative use of inotropic drugs or mechanical assistant device * ejection fraction less than 30% * combined operation using cpb such as valve surgery * previous psychiatric and neurologic disorder * inability to perform the cognitive function test

Keywords: remote ischemic preconditioning cognitive function off-pump coronary artery bypass graft
omega-3 supplementation in cervix cancer patients undergoing chemoradiotherapy

Conditions: Sarcopenia

Summary: cancer cachexia is a complex metabolic process affecting up to 80% of patients suffering from an advanced-stage cancer. moreover, 20 to 40% of all cancer deaths are caused directly by cachexia. recently, omega-3 fatty acids have gained interest for their beneficial effects in cancer cachexia. moreover, nutritional supplementation enriched with omega-3 could potentially maintain body weight in cancer patients undergoing intensive treatment. the investigators aims in this study is to evaluate the effect of omega-3 supplementation on body composition, functional capacity, inflammatory profile and quality of life in cervix cancer patients undergoing chemoradiotherapy.


Eligibility criteria:
inclusion criteria: * cervix cancer at figo stage ii and iii * chemoradiotherapy treatment proposal (cisplatin + radiotherapy) * nutritional diagnosis of pre-cachexia ou cachexia exclusion criteria: * metastasis (figo stage iv) * nutritional diagnosis of refractary cachexia

Keywords: body composition functional capacity quality of life
integrated parkinson care networks: assessment of economics and socials barriers

Conditions: Parkinson Disease

Summary: according to the latest public health report in france, parkinson's disease (pd) affects around 160,000 patients. it is therefore essential to estimate the overall consumption of medical and non-medical resources by patients with pd in order to characterize the share of medical and non-medical care reimbursed by health insurance, the share of medical and non-medical care not reimbursed. by health insurance, as well as the share of formal and informal care in order to identify potential economic barriers to an optimal care path for patients with pd. it is also necessary to have information on the socio-economic characteristics and the place of residence of the resident in order to estimate the impact of these determinants on an optimal course of care.

according to the latest public health report in france, parkinson's disease (pd) affects around 160,000 patients the coordination of the care pathway for patients with parkinson disease has been improved since the implementation on the national territory of 7 interregional coordination centers and 25 regional expert centers in 2012. health insurance reimburses 100% of direct medical and non-medical care as soon as patients are registered in long-term condition n°16. however, we currently have little information about care that is not recognized for financial coverage by health insurance. it is therefore essential to estimate the overall consumption of medical and non-medical resources by patients with pd in order to characterize the share of medical and non-medical care reimbursed by health insurance, the share of medical and non-medical care not reimbursed. by health insurance, as well as the share of formal and informal care in order to identify potential economic barriers to an optimal care path for patients with pd. it is also necessary to have information on the socio-economic characteristics and the place of residence of the resident in order to estimate the impact of these determinants on an optimal course of care.

Eligibility criteria:
inclusion criteria: * patients with parkinson's disease of any stage of severity * patients over 18 years of age * patients living at home * patient consultant at the expert center parkinson's at toulouse university hospital exclusion criteria: * pregnant and lactating woman * patient under guardianship, curatorship or safeguard of justice * person who does not understand french to be able to answer the questionnaire * patient who participated or participated in the icare pd project

Keywords: parkinson disease, socio-economic
interest of light therapy in hematology - the photo-treat study

Conditions: Leukemia, Myeloid, Acute; Lymphoma

Summary: chemo-induced mucositis is a common complication in patients treated for hematologic malignancies. they can manifest itself as a simple local irritation with erythema and inflammation but can also progress to erosions and ulcerations of the entire oral mucosa and are also responsible for an increased risk of infection in these immunocompromised patients. the only therapies currently offered are local care and intravenous analgesics. studies in pediatric hematology show the effectiveness of prevention and low-dose laser treatment in chemo-induced mucositis, both in terms of reducing the number of mucositis developed but also in terms of reducing the grade of mucositis. this currently results in a recommendation for the use of photobiomodulation by international bodies such as esmo (european society for medical oncology).

during this research, the investigators aim at validating the efficacy and impact of photo-biomodulation in the management of chemo-induced mucositis in hematology department of strasbourg cancer institute (icans).

Eligibility criteria:
inclusion criteria: * adult patient; * patients: in induction of acute myeloblastic leukemia or allografts in first remission with myeloablative conditioning or autografts in the context of aggressive lymphoma; * signature of informed consent; * patient registered with social security. exclusion criteria: * patient under guardianship or curatorship * pregnant and breastfeeding woman * allergy to polyurethanes
effects of potassium salts on blood pressure and target organ damage

Conditions: Hypertension

Summary: the purpose of this study is to determine the effect of potassium chloride and potassium bicarbonate on blood pressure and also to determine whether increasing potassium intake has beneficial effects on the surrogate markers of target organ damage in cardiovascular disease, as well as on bone health.

randomised trials have shown that increasing potassium intake lowers blood pressure. however, most previous trials used potassium chloride. whereas, potassium in fruits and vegetables is not a chloride salt, but a mixture of potassium phosphate, sulphate, citrate, and many organic anions, most of which are precursors of potassium bicarbonate. it is unclear whether non-chloride salt of potassium has greater or lesser effect on blood pressure compared to potassium chloride. experimental studies in animals and epidemiological studies in humans suggest that a high potassium intake may have beneficial effects on the cardiovascular system and the kidney, independent of its effect on blood pressure, and also reduce the risk of osteoporosis. we propose to carry out a randomised double-blind trial to compare potassium bicarbonate with potassium chloride looking at their effect on blood pressure, and also to determine whether these potassium salts have beneficial effects on the cardiovascular system, kidney and bone health. comparisons: potassium chloride vs potassium bicarbonate vs placebo.

Eligibility criteria:
inclusion criteria: * patients with untreated essential hypertension (sitting systolic blood pressure between 140 and 170 mmhg and/or sitting diastolic blood pressure between 90 and 105 mmhg); * age 18 - 75 years. exclusion criteria: * individuals younger than 18 or older than 75 years; * individuals with impaired renal function with plasma creatinine greater than 120 umol/l for non-blacks or 150 umol/l for blacks; * individuals with chronic diarrhea, or history of peptic ulcer; * individuals with baseline plasma potassium values greater than 5.0 mmol/l; * individuals with severe hypertension i.e. blood pressure \> 170/105 mmhg; * individuals with diabetes mellitus; * individuals with any secondary cause of hypertension; * individuals with malignancy or liver disease; * individuals with ischaemic heart disease or heart failure; * females who are pregnant or breast feeding or on the oral contraceptive pill.

Keywords: hypertension, potassium salts
intervention of bladder cancer by car-t

Conditions: Bladder Cancer; Urothelial Carcinoma Bladder

Summary: this is a phase i/ii and multicenter study designed to evaluate the efficacy and safety of 4scar-t cells in participants with locally advanced or metastatic urothelial bladder cancer (ubc) who have no further treatment available.


Eligibility criteria:
inclusion criteria: 1. histologically or cytologically documented locally advanced or metastatic ubc (including renal pelvis, ureters, urinary bladder, and urethra) 2. representative tumor specimens as specified by the protocol 3. adequate hematologic and end organ function 4. eastern cooperative oncology group (ecog) performance status of 0 or 1 5. life expectancy greater than or equal to (\>/=) 12 weeks 6. measurable disease, as defined by recist v1.1 exclusion criteria: 1. any approved anti-cancer therapy within 3 weeks prior to initiation of study treatment 2. treatment with any other investigational agent or participation in another clinical trial with therapeutic intent within 28 days prior to enrollment 3. active or untreated central nervous system (cns) metastases as determined by computed tomography (ct) or magnetic resonance imaging (mri) evaluation during screening and prior radiographic assessments 4. leptomeningeal disease 5. malignancies other than ubc within 5 years prior to cycle 1, day 1 6. pregnant and lactating women 7. significant cardiovascular disease 8. severe infections within 4 weeks prior to infusion 9. major surgical procedure other than for diagnosis within 4 weeks 10. history of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins; known hypersensitivity or allergy to biopharmaceuticals produced in chinese hamster ovary cells or any component of the atezolizumab formulation 11. history of autoimmune disease 12. prior allogeneic stem cell or solid organ transplant 13. history of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, idiopathic pneumonitis, or evidence of active pneumonitis on screening chest ct scan 14. positive test for human immunodeficiency virus (hiv) and/or active hepatitis b or hepatitis c or tuberculosis

Keywords: car t bladder
crestal bone loss and patient satisfaction of screw retained restoration

Conditions: Bone Loss

Summary: on of the main fixed prosthetic options of completely edentulous patients is the screw-retained implant supported prosthesis which was constructed on transmucosal abutments with its encountered problems such as: hardness to make it passively seated with multiple screw fracture and loosening problems and multiple encountered veneer material fracture and so there effect on patient satisfaction with multiple maintenance recalls.so, we want to try a new technique of fabrication which was proposed for reducing the problems of lack of passivity which is the intraoral luting cement technique on titanium bases with reduced screw number but, with luting cement problems as de-cementation and cement biological effects on soft tissues and bone and there effect on number of patient recall visits and maintenance and so there effect on patient satisfaction.


Eligibility criteria:
inclusion criteria: * completely edentulous patients * patients with completely edentulous ridges have an opposing natural dentition or implant supported overdenture * completely edentulous patients (with the above mentioned criteria) who have proper amount of attached gingiva (≥2 mm) or to be created * completely edentulous patients (with the above mentioned criteria) who have no history of bruxism * completely edentulous patients (with the above mentioned criteria) who were free or controlled diabetic assessed by measuring glycosylated haemoglobin (hba1c). (lesser than or equal to 6.4 percent ) exclusion criteria: * patients having a medical condition that absolutely contraindicates implant placement. * patients with uncontrolled diabetes, assessed by measuring glycosylated haemoglobin (hba1c). (greater than to 6.4 percent ) * potentially uncooperative patients who are not willing to go through the proposed interventions. - moderate-to-heavy daily smokers\* (who report consuming at least 11 cigarettes/day). * patients who are having complete lower denture * patients who have history of bruxism
the role of nitric oxide synthase in circulating progenitor cell function

Conditions: Cardiovascular Disease

Summary: our main hypothesis is that epc function is impaired in some populations with high cardiovascular risk as a result of reduced enos-dependent no production.

to determine if a correlation exists between epc function and enos-dependent no production in epcs from populations with high versus low cardiovascular risk: 1. high and low cardiovascular risk subjects will be identified based on age or history of cardiovascular disease. endothelial function will be measured by ultrasound. 2. epcs will be isolated from peripheral blood of these subjects. epc function will be assessed by measuring adhesion to endothelium, migration, proliferation, and differentiation, and compared to their expression and activity of enos.

Eligibility criteria:
inclusion criteria: * willing and able to give written informed consent and comply with study requirements * adult of 18 years or older * subjects willing to provide blood and tissue samples exclusion criteria: * failure to give informed consent. * those unable to consent for themselves. * those who cannot read english. * patients on viagra, levitra, or cialis * patients with malignant disease * patients with hematological abnormalities * patients with fevers of unknown origin * severe comorbidity or alcohol/drug dependence * women who are post-menopausal and on hormone replacement therapy, or premenopausal and on birth control pills (premenopausal women will be screened verbally and then by assay of lh and fsh levels in blood samples to identify women in the follicular phase of their menstrual cycle, to reduce variability)

Keywords: cardiovascular vasodilation endothelium subjects with high cardiovascular risk