Kornimate/medical-research-clean huggingface dataset:
effect of electromyostimulation on bone

Conditions: Osteopenia; Sarcopenia; Falls

Summary: although there is some evidence that whole body electromyostimulation(wb-ems) affect bone via its acute and longitudinal effects on muscle mass and strength, the corresponding impact on bone density and falls in older adults has not been assessed yet. the investigators hypothesize that wb-ems significantly affects bone parameters as assessed by dxa, and significantly reduce fall rate and ratio in a cohort of frail elderly women.


Eligibility criteria:
inclusion criteria: * female gender * 70 years and older * osteopenia according to who * bmi \< 24 kg/m2 * living independently in the area of erlangen-nurnberg exclusion criteria: * medication or diseases affecting bone metabolism (including hrt) * \> 1 hour/week of exercise * epilepsy, grave neurologic disturbances, * cardiac pacemaker, grave circulatory disorders, * abdomen/groin hernia, * tuberculosis, * cancer, * inflammable diseases, * bleeding tendencies,

Keywords: exercise whole-body electromyostimulation bone mineral density falls physical fitness pain
effects of manual therapy and exercise in the treatment of ankle sprains

Conditions: Ankle Sprains

Summary: objectives: to analyze the effects of proprioceptive and strengthening exercises versus the same exercises and manual therapy on the recurrent ankle sprain management. design: a randomized clinical trial with two intervention groups and triple blind. settings: university hospital. participants: fifty-four patients with previous history of recurrent ankle sprains, regular sports practice and pain during the physical activity, randomly assigned to experimental or control group. intervention: control group performed 4 weeks of proprioceptive and strengthening exercises; experimental group performed 4 weeks of the same exercises combined with manual therapy. main outcomes measures: pain, ankle instability, pressure pain threshold (ppt), ankle eversion strength, and active range of motion in ankle joint. the measures were taken before, after and one month after the interventions.

the recurrent ankle sprain means the most frequent complication from the ankle sprain and the previous phase of the chronic ankle stability (cai), which involves between 20 - 41% of all ankle sprains. residual pain concerns the first symptom after instability in most of the cases, but patients also show reduced ankle joint position sense, ankle range of motion, and strength of ankle inversion muscles. proprioception exercises on multiplane and unstable platforms, as well as strengthening through eccentric exercises report benefits in pain and function, suggesting the active therapy as the most effective treatment instead of passive manual therapy in chronic phases. however, several studies analyzed the effects of the manual therapy in the management of the ankle sprain recurrence: the posterior gliding of astragalus and the tibiotarsal joint coaptation improved the ankle range of motion, which was related with recurrent ankle sprain and its residual symptoms. despite the benefits from active and passive therapy, very few authors up to date investigated the combination of both clinical approach in the recurrent ankle sprain. literature analyzed the effects of a combined program including exercises to the manual therapy in acute ankle sprain and concluded that the variety in the manual therapy techniques reported more pain release and improved function. besides, based on the effects of joint mobilization techniques, the neurodynamic mobilization could be an appropriate therapy, due to the neural distribution of fibular nerve through the ankle joint, but no studies to date to our knowledge included this technique as part of the recurrent ankle sprain management. this study aimed to analyze the effects of proprioceptive and strengthening exercises versus the same exercises and manual therapy on the recurrent ankle sprain management.

Eligibility criteria:
inclusion criteria: * subjects with previous history of recurrent ankle sprain exclusion criteria: * subjects with surgical treatment, previous fractures on lower limb and/or adjacent pathologies were excluded from the study

Keywords: manual therapy proprioception exercises ankle sprain
a study of balapiravir in patients with dengue virus infection

Conditions: Dengue

Summary: this randomized, double-blind, multiple-dose, placebo-controlled study will evaluate the safety, tolerability and efficacy of balapiravir in adult male patients with confirmed dengue virus infection whose symptoms began within the 48 hours preceding the first administration of balapiravir. patients will be randomized to receive either balapiravir or placebo, orally twice daily for 5 days. anticipated time on treatment as in-patient is 7 days, with an out-patient follow-up to week 12. target sample size is \<200


Eligibility criteria:
inclusion criteria: * male patients, 18-65 years of age * dengue virus infection (confirmed by ns1 strip test) with symptom onset \</=48 hours before first study drug administration * patients and their partners of childbearing potential must use 2 forms of contraception until 3 months after receiving the last dose of study drug * bmi between 18 and 35 exclusion criteria: * positive test at screening for hiv using point of care test, or known hiv infection * history of any disease known to cause significant alteration in immunologic function or autoimmune disease * patients taking steroid or other immuno-suppressive therapies * positive test for drugs of abuse or alcohol using point of care test * clinically significant abnormal laboratory test results which are deemed unassociated with dengue infection or, alternatively, are diagnostic of dengue shock syndrome
association of the arteriovenous difference in carbon dioxide and its relation to the difference in arteriovenous oxygen content with the occurrence of postoperative complication

Conditions: Surgery--Complications

Summary: intra-operative hemodynamic management in high-risk surgery is a priority for the anesthesiologist. the current strategy is based on the continuous measurement of cardiac output and its maximization by vascular filling has many limitations: invasiveness, measurement difficulties, impaired performance, imperative surgical restriction of filling, lack of evaluation of flow rate and metabolic needs. biomarkers may be able to detect early an inadequacy between cardiac output and tissue oxygen requirements, venous saturation with oxygen (scvo2) and arteriovenous difference in partial pressure of carbon dioxide (δpco2) as well as the appearance of cellular hypoxia (lactate and arteriovenous difference in partial pressure of carbon dioxide/arteriovenous difference in oxygen) (δpco2) / davo2). moreover, the medical literature remains poor on the evaluation of these markers in per-operative context all the more for δpco2 and δpco2 / davo2. it seems interesting to evaluate the potential of these tools, in patients with major surgery and at high risk (major hepatectomy, oesophagectomy and duodeno-pancreatectomy), to predict the risk of postoperative complications, especially since surgery involves a restrictive vascular filling strategy that may be potentially deleterious to the patient.


Eligibility criteria:
inclusion criteria: major patient patient eligible for a high risk scheduled gastrointestinal surgery from: * esophagectomy * major hepatectomy (≥ 3 segments) * cephalic duodeno-pancreatectomy patient with an arterial catheter and a central venous line in superior vena cava. patient hospitalized post-operatively in intensive care unit as agreed in consultation with preoperative anesthesia. exclusion criteria: * pregnant or lactating patients * patient with an unstable acute condition at the time of surgery (acute heart, respiratory or renal failure, severe sepsis or septic shock, hemorrhagic shock) * patient opposing his participation in the study * patient protected by law (guardianship) * patient deprived of liberty * patient with a contraindication to the establishment of a central venous route in superior vena cava territory or a radial or femoral arterial catheter

Keywords: high-risk digestive surgery intensive care unit
synovium brushing to augmented microfracture for improved cartilage repair

Conditions: Defect of Articular Cartilage; Cartilage Injury; Osteoarthritis, Knee

Summary: this is a proof-of-concept study to determine the safety and efficacy of a novel device to increase the reparative capacity of the knee. the discovery of a resident population of mesenchymal stem cells (mscs) within synovial fluid (sf) was the first description of this reparative cell population having direct access to superficial cartilage and joint structures. the ready access of sf msc to cartilage and other joint tissues offers a novel strategy for joint repair. current arthroscopic procedures result in the removal of all sf mscs due to continuous irrigation throughout the procedure. the current study would benefit the patient by greatly increasing the reparative capacity of the joint by bolstering msc numbers and retaining those mscs within the joint after surgery. by accessing mscs from the synovium it is anticipated that these cells would be entrapped/migrate into the marrow clot formed by microfracture of the sub-chondral bone. these mscs would supplement those from the marrow and may result in faster, better quality repair.

the synovium is a rich source of potent chondrogenic mesenchymal stromal cells (mscs). gaining access to this valuable source of regenerative cells could improve the outcome of joint restorative procedures. to avoid costly two-stage procedures and ex vivo manipulation, exploiting these autologous cells in a minimally invasive way with minimal manipulation could provide a novel cost-effective approach. this study will evaluate the safety, feasibility and efficacy of a novel medical device (a synovial brush) and procedure (synovial brushing) to increase the number of autologous minimally manipulated mscs in the knee. twenty patients undergoing microfracture for isolated chondral defects will be randomly assigned to either a control group (microfracture only, 10 patients) or the intervention group (microfracture plus synovial brushing, 10 patients). the device is intended to increase the number of mscs within the joint as a final stage during surgery, aiding repair by bolstering those mscs recruited from the bone marrow.

Eligibility criteria:
inclusion criteria: * isolated cartilage defects (\<2cm2) * patients undergoing microfracture for repair of cartilage defects exclusion criteria: * septic arthritis * infectious disease * revision joint surgery * meniscal damage requiring repair * ligament damage requiring repair * cartilage defect greater than 2cm2 * contra-indications for mri: * pacemakers, implantable cardioverter defibrillators, implantable cardiac loop recorders * surgical clips within the head * certain inner ear implants * neuro-electrical stimulators * metal fragments within the eye or head

Keywords: cartilage mesenchymal stromal cell microfracture knee defect injury stem cell autologous minimally manipulated
reducing acute upper gastrointestinal side-effects of thoracic irradiation

Conditions: Radiation Esophagitis

Summary: the purpose of the study is to explore options for preventing and reducing symptoms of radiation esophagitis (re). the researchers will also look what symptoms participants experience, and whether there are differences in weight loss in participants.

embedded randomized study to assess two-stage consent design: there will be two separate randomizations in this study, one vs. two-stage consent and sucralfate vs. control. the will first approach patients and explain that we are comparing different methods of informing patients about trials. if the patients do not wish to participate in the consent trial, participants will be approached for consent onto the therapeutic trial using the traditional onestage research consent. patients who decline or who are not approached to take part in the randomized compression of consent methods based on physician discretion, may still take part in the randomized comparison of sucralfate vs. control (therapeutic trial).

Eligibility criteria:
inclusion criteria: * patients being treated with thoracic irradiation with high-risk esophageal dose as determined below: esophageal dose: * v50 ≥ 15% (25-35 once daily fractions) or 40 twice-daily \[bid\] fractions) * v40 ≥ 15% (15-24 once daily fractions or 30 twice-daily \[bid\] fractions) * v30 ≥ 15% (10-14 once daily fractions) * age 18 years of age or older. exclusion criteria: * known inability to take sucralfate (tablet and/or suspension form), per physician discretion * peg tube * actively taking any opioid pain medications prior to radiation therapy * history of an opioid use disorder

Keywords: gastrointestinal sucralfate radiation therapy thoracic cancer 22-307
pre-treatment with methylene blue prevent peri-operative reduced systemic vascular resistance

Conditions: Obstructive Jaundice

Summary: to explore the effects of pre-treatment with methylene blue on reduced perioperative vascular resistance in patients with obstructive jaundice.

hemodynamic characteristics of patients with obstructive jaundice are high cardiac output, low peripheral vascular resistance. the molecular basis for this feature is the increased production of no. methylene blue can increase peripheral resistance, the mechanism is: methylene blue is an oxidoreductase inhibitor, can inhibit the increased production of no in the vascular endothelium, thereby increasing peripheral vascular resistance.

Eligibility criteria:
inclusion criteria: 1. aged between 18-60 years; 2. american society of anesthesiologists（asa） grade i\~iii; 3. tbil\>uln and tba\>uln; the patients with obstructive jaundice. exclusion criteria: 1. organs dysfunction(heart,lungs and etc); 2. mental disorders; 3. in other clinical trial.

Keywords: methylene blue; peripheral vascular resistance
sleep profiles in rem sleep behavior disorder

Conditions: Rapid Eye Movement Sleep Behavior Disorder

Summary: rapid eye movement (rem) sleep behavior disorder (rbd) is a sleep disorder in which you act out dreams during rem sleep. sleep disturbances are very common in rbd, where they negatively impact patients' quality of life and safety. one of the known causes of sleep disturbance is the impairment of the "circadian rhythm", or the human sleep/wake cycle. the purpose of this study is to examine the role of disruption of the circadian rhythm in the development of rbd.


Eligibility criteria:
inclusion criteria: 1. diagnosis of rbd as assessed by the international classification of sleep disorders (icds) diagnostic criteria within 3 years 2. 40 yrs of age exclusion criteria: 1. other significant neurological disorder 2. untreated significant sleep apnea and/or current sleep apnea symptoms as assessed by the clinical investigator 3. co-existent restless legs syndrome (rls), as assessed by the icds diagnostic criteria for rls 4. cognitive impairment as determined by the montreal cognitive assessment (moca) score of ≤ 23 5. presence of depression defined as the beck depression inventory (bdi) score \>20 6. use of tricyclic antidepressants, mao inhibitors or selective serotonin reuptake inhibitors since they may induce/worsen rbd, unless on a stable dose of medication for at least 8 weeks 7. use of medications known to affect melatonin secretion, such as lithium, α- and β-adrenergic antagonists 8. shift work, currently or within the prior 3 months 9. travel through ≥ 2 time zones within 60 days prior to the screening
depuy synthes variable angle lcp patella plating system study

Conditions: Trauma; Patella Fracture; Knee Cap; Knee Cap Injury; Knee Discomfort; Knee Deformity

Summary: the depuy synthes locking compression plate (lcp) variable angle patella plating system is an fda approved device. the purpose of this study is to see how well the depuy synthes lcp variable plating system work in fixing a broken kneecap (patella). depuy says that the device will improve healing when compared to traditional ways of repairing a broken patella. the goal of this randomized control trial is to learn how well the lcp variable plating system works to fix a broken patella (kneecap) compared to traditional fixation methods, in male and females, age 18 to 74, with a patellar fracture, and being treated at hartford healthcare the bone and joint institute or hartford hospital. the main question it aims to answer are: * to understand if the depuy synthes lcp variable angle plating system will provide a better way to help patients recover from a broken patella. participants will evaluated at specific time points: post-op day 1, 6 weeks, 3 months, 6 months, and 12 month post-surgery. participants will be asked to: * complete surveys at all evaluation timepoints. * have x-rays(radiographs) taken at the 6 week, 3 month, 6 month, 9 month, and 1 year timepoints. * participants will have a passive range of motion tests done at 6 week, 3 month, 6 month, 9 month, and 1 year timepoints. * participants would have strength and balance tests done at the 3 month, 6 month, 9 month, and 1 year timepoints.


Eligibility criteria:
inclusion criteria: * males and females * age between 18 and 74 years old (inclusive) * patellar fracture * treated at hartford healthcare the bone and joint institute or hartford hospital exclusion criteria: * age greater than or equal to 75 or less than 18 * patients that are non-ambulatory/limited ambulation prior to their injury * previous patellar fracture * pre-existing osteoarthritis of the knee * ipsilateral femoral or tibia fractures

Keywords: patella plating trauma kneecap injury knee injuries knee injury fracture break randomized
fear of fall related factors in chronic stroke

Conditions: Stroke; Fall

Summary: some stroke survivors develop a fear of falling(fof) which may exist with or without a prior fall. fear of fall can be defined as decreased perceived self efficacy or confidence in maintaining balance while completing regular activities. fof may impair rehabilitation and recovery. determination of fof related factors will help to identify interventions needed to decrease fof. mostly fear of fall related factors have been studied in acute stroke patients, limited data are available for patients with chronic stroke. the objective of this study is to evaluate frequency of fof in chronic(\>6 months) stroke patients and investigate relationship between fof and balance, posture,spasticity and activities of daily living. the turkish version of the modified falls efficacy scale was used to measure fof. also a single-item dichotomous question "are you afraid of falling? (yes/no)" will be asked.

in this observational study, chronic(\>6 months) stroke patients who admitted to physical medicine and rehabilitation outpatient clinic, older than 50 years old will be included. sociodemographic and medical data including patients' age, gender, height, weight, body mass index, contact information, marital status, educational status, plegia side, stroke etiology, time after stroke, accompanying diseases, medications used, fear of falling (yes/no), history of falling (yes/no), and the use of walking aids will be recorded. in the evaluation of patients, brunnstrom hemiplegia recovery staging, functional ambulation classification (fac), mini mental state examination(mmse),turkish version of modified falls efficacy scale(mfes), berg balance scale(bbs), postural assessment scale for stroke patient turkish version (pass-turk), modified ashworth scale (mas), modified barthel activities of daily living index will be used. fear of falling will be evaluated by the same researcher using the mfes. also a question " are you afraid of falling? (yes/no)" will be asked. the patients will be divided into two groups as group 1 =mfes\<5 and group2 =mfes ≥5. balance, posture, ambulation status, spasticity, daily living activities and brunnstrom staging will be compared between two groups. correlation between mfes and balance, posture and activities of daily living will be studied.

Eligibility criteria:
inclusion criteria: * patients aged 50 and over * more than 6 months after the stroke * able to follow 3-digit orders * able to approve the consent form in writing * patients with a score of 23 and above on the mini-mental state test will be included exclusion criteria: * bed-dependent, wheelchair-dependent patients * patients diagnosed with alzheimer's, dementia * patients who are cardiovascularly unstable * patients with diseases that affect balance (such as parkinson's disease, cerebral trauma, meniere, ear infection, benign paroxysmal positional vertigo, multiple sclerosis) and those who use drugs that disrupt the balance

Keywords: stroke hemiplegia falls fear posture
skeletal muscle atrophy and dysfunction in human cancer

Conditions: Nonsmall Cell Lung Cancer

Summary: cancer and its treatment can have profound effects on skeletal muscle, the most well-recognized being atrophy, weakness and diminished oxidative capacity. these adaptations negatively impact quality of life, treatment decisions and survival. despite these consequences, the factors promoting these adaptations remain poorly defined and understudied in human patients. to address this gap in knowledge, our goal in this study is to examine the role of muscle disuse as a regulator of muscle size and function in human cancer patients


Eligibility criteria:
inclusion criteria: * 50-75 yrs of age * histologically-documented, stage iii or iv non-small cell lung carcinoma (nsclc) * estimated life expectancy \>6 mos * karnofsky's performance score of ≥70 exclusion criteria: * history, signs or symptoms of inflammatory or autoimmune disease * uncontrolled hypertension * heart or renal failure * exercise limitations from peripheral vascular disease or stroke * neuromuscular disease * knee/hip replacement * additional, actively-treated malignancy or history of malignancy, except non-melanoma skin cancer * taking medication that can have anti-coagulant effects that cannot be stopped prior to the muscle biopsy
mask adhesive institutional study

Conditions: Respiratory Failure; Covid19

Summary: to reduce interface leak and aerosol spread, philips has developed an accessory to non-invasive ventilation(niv) masks to be used with the philips af531 and the performatrak mask on respiratory failure patients. for the purposes of capturing initial mask leak and safety data, this trial will enroll patients treated with niv in an institutional setting (i.e., sleep lab).

the mask adhesive will serve as an accessory to the af531/performatrak masks with the intention to reduce patient leak while a patient is receiving therapy. this accessory is a double-sided adhesive; with one side applied directly to the patient's skin and the other side connected to the mask cushion. each adhesive is only to be applied to a patient once. the af531/performatrak mask can be removed from the adhesive and then re-applied, as necessary. for example, if the patient needs to remove the mask to eat or take medicine, the mask is removed from the patient and the adhesive will stay on the patient's face

Eligibility criteria:
inclusion criteria: * adults patients age 18 to 85 (inclusive) * adult patients treated with niv * able to read, write, and speak english * able to provide written informed consent * willing to have facial hair removed for adhesive placement (if required) exclusion criteria: * pre-existing allergy to tape or adhesive; * blisters, open skin or pre-existing skin condition that may impact the ability to support removal of the mask adhesive without tearing the skin * pregnant (for females of childbearing age); * individuals sentenced to such an institution under a criminal or civil statute, * individuals detained in other facilities by virtue of statutes or commitment procedures which provide alternatives to criminal prosecution or incarceration in a penal institution, and individuals detained pending arraignment, trial, or sentencing