Kornimate/medical-research-clean huggingface dataset:
nutrition health literacy of cancer patients and their support networks.

Conditions: Cancer; Oncologic Disorders; Haematological Malignancy; Nutrition Aspect of Cancer

Summary: an exploration of the impact of nutrition literacy on ability of cancer patients and their support networks to get, understand and use nutrition information during cancer treatment.

the study is composed of two component projects: project a: validation of a nlit tool for uk population. nlit tool is a measurement tool developed at kansas university to measure nutrition health literacy. it assesses the following functional literacy skills: numeracy \& literacy and the following nutrition knowledge fields: macronutrients, food labels, portion sizes, food groups and consumer skills. this project has two phases: phase a: nominal consensus groups x 2 - consumer adaptation and tool review for uk use and pilot testing of electronic tool. phase b: testing adapted tool in a group of cancer patients for statistical validation. project b: planned survey of people with cancer and their families to explore experiences of access to nutrition information this survey is a combination of validated and unvalidated questions built on models of nutrition health literacy. with validated fields being used to evaluate and understand responses to unvalidated questions. it explores access to nutrition information, self-efficacy, confidence, health care infrastructure and support with nutrition information, population demographics, food security, sources of nutrition information, perceived practical skills and knowledge base.

Eligibility criteria:
nlit-uk development inclusion criteria: * members of the public (carers, health service users, lay persons) * cancer patients with confirmed diagnosis * friends or family members supporting a patient with a confirmed diagnosis of cancer * \> 18 yrs old * received cancer treatment at nottingham university hospitals between jan 15 and march 20 exclusion criteria: * paediatrics \< 18yrs at the time of diagnosis and treatment * unconfirmed diagnosis of cancer * patients on watch and wait

Keywords: nutrition health literacy education information knowledge
single-level tlif: post-fusion rehabilitation

Conditions: Degenerative Spinal Cord Disease

Summary: this investigation will assess how the timing and type of rehabilitation after a transforaminal lumbar interbody fusion will affect the efficacy of the surgical procedure. the efficacy of the procedure will be evaluated through patients' quality of life, measured by health-related quality of life questionnaires up to 24 months following the procedure. these measures will be compared to the patients' baseline value.

patients will undergo transforaminal lumbar interbody fusion for degenerative pathology at the l4-5 vertebral level. they will be randomized to one of three postoperative rehabilitation groups. group 1 will receive "structured early rehabilitation" beginning at 7 weeks. group 2 will receive "delayed rehabilitation" beginning at 13 weeks postoperatively. group 3 will undergo "self rehabilitation" beginning at 7 weeks postoperatively. groups 1 and 2 will undergo rehabilitation under the supervision of a certified physical therapist for 10 total weeks. group 3 will undergo non-supervised rehabilitation for 10 total weeks, and will be given educational materials regarding which exercises to perform and at which intervals.

Eligibility criteria:
inclusion criteria: i. single-level l4-l5 tlif for degenerative pathology, including: radiculopathy, neurogenic claudication, intervertebral disc disease, facet joint disease, degenerative spondylolisthesis, degenerative myelopathy degenerative kyphosis and scoliosis ii. back and/or leg pain iii. failed at least 3 months of conservative treatment exclusion criteria: i. older than 65 years of age ii. prior spinal surgery excluding laminectomy/discectomy iii. greater than grade 2 spondylolisthesis iv. greater than 10 degrees scoliosis v. not worked for greater than 6 months or unemployed as a result of lumbar condition vi. history of spinal infection
adaptation of the intensive care unit-specific pressure injury risk scale to turkish (raps-icu)

Conditions: Pressure Injury; Reliability and Validity; Intensive Care Units (ICUs); Assessment Scale

Summary: the aim of this study was to evaluate the translation, cross-cultural fit, and psychometric properties of the icu-specific pressure injury risk scale

this was a prospective, cross-sectional study aimed at translation and cultural adaptation of the raps-icu into turkish, while also assessing its validity and reliability.patients who meet the inclusion criteria and who are hospitalized in the intensive care clinics of istinye university bahçeşehir liv hospital and harran university hospital will participate in the study. in this study, turkish adaptation of the 'intensive care unit-specific pressure injury risk assessment scale' is planned. after language adaptation, its validity and reliability will be tested. the reliability of the intensive care unit-specific pressure injury risk assessment scale will be assessed by inter-rater reliability and internal consistency (determined by calculating cronbach alpha coefficient), and its validity will be assessed by convergent and divergent validity of the scale. relative reliability was obtained by calculating the intraclass correlation coefficient (icc). relative reliability will be obtained by calculating the intraclass correlation coefficient (icc). the receiver operator characteristics (roc) curve has been used to estimate sensitivity and specificity and will represent the false positive rate versus the true positive rate across various thresholds for different scores.

Eligibility criteria:
inclusion criteria: * 18 years of age or older, * staying in the intensive care unit for at least 1 day, * agreeing to participate in the study by themselves or a family member. * volunteering to participate in the research * full orientation and no psychiatric problems exclusion criteria: - having communication problems

Keywords: pressure injury reliability and validity intensive care units assessment scale
topical application of as101 for the treatment of atopic dermatitis

Conditions: Atopic Dermatitis

Summary: atopic dermatitis is a chronic non contagious disease that causes itchy, inflamed skin. the purpose of this study is to evaluate the safety and efficacy of topical as101 ointment for the treatment of atopic dermatitis.

atopic dermatitis (ad) is the most common chronic inflammatory skin disease, affecting 10-20% of children and 2% of adults worldwide. the mechanism of ad is still not completely understood, but the disorder appears to result from the complex interaction between immunological responses, various susceptability genes, defects in skin barrier function, host and environmental factors and infectious agents. as101 is a non toxic potent immunomodulator that has been shown to have beneficial effects in diverse pre clinical and clinical studies. recently, as101 has shown efficacy and safety in the treatment of mild to moderate psoriasis which shares with ad a related immunological mechanism along with the as101 ability to decrease the level of interleukins known to be involved ith the pathogenesis of ad.

Eligibility criteria:
inclusion criteria: * diagnosed atopic dermatitis for at least 6 months prior to enrollment. * diseased body surface area (bsa) ≤ 20%. * male and female ≥ 18. * adequate general health. * signed informed consent form by the patient or his/her legal guardian. * patient must be able and willing to comply with all protocol requirements. exclusion criteria: * patient who is unable to provide fully informed consent. * pregnant of breast-feeding females. * concomitant dermatologic or medical condition(s) which may interfere with the patient's response evaluation. * evidence of an infection in the targeted zones. * known sensitivity to any of the drug component. * immunocompromised patients. * concomitant medications such as: * topical corticosteroid within 2 weeks prior to day 1 visit; * systemic steroids and immunosuppressants within 1 month prior to day 1 visit; \*systemic anti-histamines and antibiotics within 2 weeks prior to day 1 visit; \*phototherapy within 4 weeks prior to day 1 visit; * anticipated exaggerated exposure to sunlight during the whole treatment period and 4 weeks prior to day 1 visit.
influence of variations of systemic venous return on analgesia nociception index (ani) during general anaesthesia

Conditions: Hypovolemia; Somatic Pain

Summary: the purpose of this study is to determine whether the value of analgesia nociception index (ani) is influenced by variations of systemic venous return (cardiac preload) under general anaesthesia.

in the context of opioid sparing goal during general anaesthesia, the analgesia nociception index (ani) is an analgesia/nociception balance monitoring tool computed from high frequency heart rate variability analysis, and developed by metrodoloris (lille, france). its sensitivity to detect noxious stimulus was studied in several studies. however, its specificity is not established in particular in the presence of factors influencing autonomic nervous system other than analgesia/nociception balance. in the context of anaesthesia, one of the most relevant factor is hypovolemia. this study aims to assess the effect of blood volume variations on ani under general anaesthesia, independently of analgesia/nociception balance status. variations of systemic venous return (svr) (cardiac preload), which reflects blood volume status, will be induced by changes of operating table slope, from head-down tilt (trendelenburg), with increased svr, to head-up tilt position, with decreased svr. variations of svr will be attested by changes in the arterial pulse pressure variation, a well-established indice of preload responsiveness in the mechanically ventilated anaesthetized patient.

Eligibility criteria:
inclusion criteria: * neurosurgical operation requiring invasive monitoring of arterial blood pressure exclusion criteria: * pacemaker, arrhythmia * chronic medication with beta blocker * possible disorder of autonomic nervous system: diabetes, alcoholism, chronic pain * anticholinergic drug administration before measures * intracranial hypertension * no social security coverage * pregnancy

Keywords: analgesia nociception index heart rate variability autonomic nervous system specificity systemic venous return pulse pressure variation intraoperative monitoring
effect of oral enteral nutrition on severe traumatic brain injury

Conditions: Traumatic Brain Injury

Summary: this was a multicenter randomized controlled study of 98 severe traumatic brain injury patients with tracheostomy. patients enrolled were divided randomly into the observation group with intermittent oro-esophageal tube feeding (n=50) or the control group with nasogastric tube feeding (n=48) for enteral nutrition support, respectively. nutritional status, complications, decannulation of tracheostomy tubes and level of consciousness on day 1 and day 28 were recorded and compared.

the safe and effective nutrition support for severe traumatic brain injury patients with tracheostomy continues to be a challenge. nasogastric tube feeding has been the mainstream choice in china but with the risk of complications. intermittent oro-esophageal tube feeding is an established modality of enteral nutrition support that can be used with routine treatment. this study reports the clinical outcomes of intermittent oro-esophageal tube feeding vs. nasogastric tube feeding, in patients receiving routine treatment. this was a multicenter randomized controlled study of 98 severe traumatic brain injury patients with tracheostomy. patients enrolled were divided randomly into the observation group with intermittent oro-esophageal tube feeding (n=50) or the control group with nasogastric tube feeding (n=48) for enteral nutrition support, respectively. nutritional status, complications, decannulation of tracheostomy tubes and level of consciousness on day 1 and day 28 were recorded and compared.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years, meeting the diagnosis of severe traumatic brain injury, confirmed through mri * score of glasgow coma scale (gcs) \<8; * presence of no contraindication for enteral nutrition; * with stable vital signs and no severe liver or kidney dysfunction, metabolic disorders, cardiovascular diseases, or multiple complications; * informed consent form was obtained from the patient\&#39;s family members. exclusion criteria: * unable to cooperate in completing treatment and assessment due to personal reasons or other disorders; * complicated with other intracranial lesions, such as stroke; * with severe consciousness disorders caused by other diseases.
predicting female pelvic tilt and lumbar angle using machine learning in case of urinary incontinence and sexual dysfunction

Conditions: The Purpose of This Study is to Predicting Female Pelvic Tilt and Lumbar Angle Using Machine Learning in Case of Urinary Incontinence and Sexual Dysfunction

Summary: the purpose of this study is to predicting female pelvic tilt and lumbar angle using machine learning in case of urinary incontinence and sexual dysfunction

92 patients were distributed randomly into two groups. the first group will be measured pelvic tilt, lumbar angle by spinal mouse and force of contraction of pelvic floor muscles by ultrasound imaging, udi-6 and fsfi questionnaires for urinary incontinence female the second group will be measured pelvic tilt, lumbar angle by spinal mouse device and force of contraction of pelvic floor muscles by ultrasound imaging, udi-6 and fsfi questionnaires for normal females. patients will be examined by radiologist with medical ultrasound imaging and by me with spinal mouse device.

Eligibility criteria:
inclusion criteria: * - their ages varied from 30to 40years, their body mass index (bmi) was 25-30 kg/m2 and a number of parities ≤ three normal vaginal deliveries, at least two years and subjects hadn't received drugs, patients with mild and moderate urinary incontinence with sexual dysfunction exclusion criteria: - 1. history of spinal surgery or spinal fracture. 2. volunteers with a history of a recto-vaginal or vesico-vaginal fistula, undiagnosed uterine bleeding urinary tract infection, diabetes, intrauterine device, chest and/or cardiac disease and using any drugs for urinary incontinence 3. serious diseases, such as heart disease, kidney, liver diseases, gastric ulcer or duodenal ulcer. 4. a history of bronchial asthma or any chest disease. 5. uncontrolled diabetes or hypertension. 6. patients with peacemaker or any metal implant on the treated area. 7. cancer or patient with past history of tumor excision.
regular use of apdt in the management and prevention of periodontitis symptoms in diabetic patients

Conditions: Diabetes Mellitus, Type 2; Pre-diabetes; Periodontal Diseases; Periodontitis

Summary: this is an investigator-initiated clinical study to establish easy referral and access for diabetic patients from primary health care to oral health care facilities for preventive oral care, periodontal assessment, and treatment, and to investigate the impact of regular home use of apdt medical device on plaque control and gingival health, when used as an adjunct treatment to standard oral hygiene, and the effect on diabetes control in patients with the risk of periodontal disease, compared to a standard home care oral hygiene regimen.

in earlier studies, a bi-directional link between diabetes and periodontitis has been established: high glucose levels increase the risk of periodontitis while glycemic control is likely to worsen with untreated periodontitis. the treatment of diabetic patients should include easy access from diabetes clinics to oral health care facilities to reduce the potential risks of periodontal disease, or deterioration of existing symptoms of periodontal disease. as part of a holistic approach to healthcare and its resources, more attention needs to be paid to the early detection, and prevention of oral diseases in diabetic patients. novel testing and treatment methods can play a key role, and a good collaboration between diabetes and oral health care facilities is essential. the ammp-8 test can be used to assess the risk of periodontal disease. if the test is positive, latent mmp-8 is activated, so the inflammatory cascade is activated and provides real-time information. the test can also be used to monitor the success of the treatment outcome and can be used to determine the interval between maintenance treatments. in addition, patients' oral self-care should be improved, as most of the work in preventing oral diseases is done at home. the home use of photodynamic dual light therapy (apdt) can provide additional benefits and also engage patients not only in self-care but also in the whole treatment process. preliminary studies show that apdt improves the treatment and maintenance outcomes, and potentially reduces the risk of periodontal disease in addition to self-care. the combination of easy access to treatment could have wide benefits individually, and also at the community level, including the possibility of building a cost-effective preventive care pathway for patients with prediabetes, type 2 diabetes, and periodontitis, and identifying the risks of both diseases and treating already detected diseases early and in a timely manner.

Eligibility criteria:
inclusion criteria: * diabetic patient treated at community health care; * at least 18 years old; * presence of ≥20 teeth; * agreement to participate in the study, and to sign a written consent form; * ability to cooperate with the treatment protocol according to coordinator investigator's assessment. exclusion criteria: * oral thrush; * known sensitivity to near-infrared or antibacterial blue light.

Keywords: periodontitis diabetes t2d apdt ammp-8
use peripheral blood proteomics to predict the treatment response and toxicities in nsclc immunotherapy

Conditions: Non Small Cell Lung Cancer

Summary: peripheral blood contains enormous quantity of biological information that can improve our patient care. investigators plan to use proteomics from serum to study its value in predicting the therapeutic response and toxicities of immunotherapy in non-small cell lung cancer (nsclc).

an extra tube of blood for research will be collected from consented subjects prior to the initiation of anti-pd-1/l1 based immunotherapy, either single agent or in combination with chemotherapy. the blood will be coded, processed and sent for analysis. results of analysis will be correlated with clinical data to see whether serum proteomics can be a good therapeutic predictor for future studies and treatments of nsclc.

Eligibility criteria:
inclusion criteria: * non small cell lung cancer (nsclc) patients who were previously untreated receiving anti-pd1 or anti-pd-l1 therapies, either single agent or in combination with chemotherapy. * nsclc patients who were treated with one previous line of therapy (not containing io) and now receiving anti-pd1 or anti-pd-l1 therapies, either single agent or in combination with chemotherapy. exclusion criteria: * patients not capable of making medical decisions * any patients who do not meet the inclusion criteria
non-pharmacological methods for reducing pain during vaccination in infants

Conditions: Pain; Breast Feeding; Maternal Behavior

Summary: pain management in infants is a medical responsibility of all members of the healthcare team, and nurses hold a privileged role in this regard. the primary goal of pain management is to accurately assess and identify the infant's pain at an early stage, support the development of coping mechanisms through both pharmacological and non-pharmacological methods, and minimize the pain experience as much as possible. pain management achieved through non-pharmacological interventions constitutes a safe, non-invasive, cost-effective, and independently performed nursing practice. this randomized controlled study was conducted to determine the effect of non-pharmacological methods, specifically maternal holding and breastfeeding, on reducing pain during vaccination in infants.


Eligibility criteria:
inclusion criteria: * being healthy, * aged between 4 weeks and 6 months, * parents have given verbal and written consent to participate in the study, * born at term (37 weeks of gestation or later), * scheduled for vaccination under the ministry of health's vaccination program, * not having taken analgesics/antipyretics in the last 4 hours before the procedure, * having a normal body temperature (between 36.5°c and 37.1°c). exclusion criteria: * having a chronic or mental illness, or a congenital anomaly, * being older than 6 months, * having a body temperature above 37.1°c, * receiving analgesics, sedatives, or any other medication.

Keywords: pain vaccines nursing breastfeeding maternal holding infants
group eczema education visits:impact on patient and family quality of life

Conditions: Eczema

Summary: the objective of this study is to determine whether group educational visits improve the quality of life of patients referred to the dermatology clinic. secondary outcomes will be to determine whether group educational visits influences other key elements of patient care such as topical steroid usage, disease exacerbations, emergency visits, and phone calls to the office. lastly, the investigators hope to evaluate which aspects of the educational visit were found to be the most helpful to families caring for children with atopic dermatitis (ad). patients will be new atopic dermatitis referrals to ohsu dermatology and pediatric dermatology clinics. all consecutive patients with such appointments during a three month time period will be screened for participation in the study. parents will be recruited via telephone. in the intervention group, parents will be invited to participate in a group education visit prior to their first appointment with a dermatologist. all parents in the study will fill out questionnaires. the children involved in the study will be assigned an eczema severity score during their routine visits, but this will be incorporated into the regular clinic assessment. the childhood atopic dermatitis impact scale (cadis) assesses the quality of life in households with children who have atopic dermatitis. the eczema area and severity index (easi) measures the extent and severity of the patient's atopic dermatitis. the change in cadis scores will be analyzed to determine if there is a more significant improvement in quality of life for the group in which parents receive the group eczema education visit.


Eligibility criteria:
inclusion criteria: * children ages 2 months though 6 years. * participants must carry a diagnosis of atopic dermatitis according to the hanifin and rajka criteria. * new patients or consultations at an ohsu clinic. * english-speaking families will be included in this study exclusion criteria: * subjects who have been on systemic therapies for treatment of their atopic dermatitis (prednisone or cyclosporine)

Keywords: group eczema education