Kornimate/medical-research-clean huggingface dataset:
diastasis recti abdominis and a combined treatment with abdominal exercise and radiofrequency

Conditions: Diastasis; Diastasis Recti; Diastasis Recti and Weakness of the Linea Alba; Diastasis Recti Abdominis

Summary: diastasis recti abdominis is a pathology that appears in a high percentage of women during the postpartum period. however, there is little evidence about its treatment. the present protocol aims to evaluate the efficacy of radiofrequency as an alternative for the treatment of abdominal diastasis along with abdominal exercises compared to the only intervention through abdominal exercise. an aleatory clinical testing will be conducted where 44 women diagnosed with diastasis recti abdominis in the postpartum period will be recruited. a common exercise protocol will be applied for two groups of participants, and both of them will have to be able to carry out the activities autonomously at home. in addition, control sessions will be held weekly for both groups where one of the groups, the control group (n=22), will receive radiofrequency therapy with the machine in athermic mode, while the other group, the experimental group (n=22), will receive a weekly session under the established diathermy protocol. the sessions will last 30 minutes and will take place for 10 consecutive weeks. three variables will be evaluated: the width of the diastasis measured in centimeters, life quality measured using the short form (36) questionnaire, and the perception of the pain measured with the visual analogue scale. three evaluations will be done: at the beginning of the study, after ten weeks and three months later.


Eligibility criteria:
inclusion criteria: * women diagnosed with diastasis recti abdominis (dra) * age range18-45 years old * women not dra treated previously * women not diagnosed with umbilical hernia exclusion criteria: * dra width less than 2.5cm * women diagnosed with intestinal disease such as irritable bowel syndrome (ibs) or chron disease. * women looking for a new pregnancy or pregnant women. * women who can not receive diathermy treatment (e.g tumoral process, open wound in the abdominal area or any diathermy contraindication).
voice rest and injection laryngoplasty

Conditions: Vocal Cord Paralysis

Summary: the purpose of this study is to evaluate the subjective, objective, and aerodynamic impact of voice rest following injection augmentation and compare the outcomes to patients with no post-procedure voice restrictions.

glottic insufficiency resulting from vocal fold immobility can have a significant negative impact on health and quality of life and is a major cause of dysphonia, dysphagia, and dyspnea. vocal fold immobility can be unilateral or bilateral and complete or partial. most commonly, it is caused by iatrogenic injury to the recurrent laryngeal nerve from thyroidectomy or anterior cervical disc fusion surgeries. other causes include traumatic, idiopathic, malignant, and neurogenic. variability exists in approach to surgical management. degree of spontaneous recovery and thus timing of intervention varies based on severity and permanency of neurological injury. initially described by wilhelm brünings in 1911, injection laryngoplasty, also known as injection augmentation, is a technique to improve glottic closure by injection of material to move the immobile vocal fold closer to midline. this improves voice quality and strain in patients with either unilateral or bilateral vocal fold hypomobility, immobility, atrophy, presbylarynx, vocal fold scar, and soft tissue loss. improvement in glottic closure also results in better swallowing outcomes. injection augmentation can be performed under general anesthesia in patients unable to tolerate the procedure while awake. injection can be performed peroral, through a working channeled flexible laryngoscope, or a percutaneous approach. percutaneous approaches can be further divided into transthyroid cartilage, transcricothyroid membrane, or transthyrohyoid membrane. all cases are performed under endoscopic guidance to ensure correct needle placement and adequate medialization of affected vocal fold. congruent with the heterogeneity of injection laryngoplasty materials, approaches, and techniques, there also appears to be no data or expert consensus regarding voice rest following this procedure. this study aims to quantify the benefit of voice rest following vocal fold injection augmentation.

Eligibility criteria:
inclusion criteria: 1. age \>18 years old 2. undergoing injection augmentation by dr. mcgarey, dr. torrecillas, or dr. daniero for the following conditions: 1. glottic insufficiency from atrophy, scar, or presbylarynx 2. unilateral or bilateral vocal fold immobility 3. unilateral or bilateral vocal fold hypomobility exclusion criteria: 1. prior history of head and neck radiation. 2. active or recent (within 3 months) chemotherapy. 3. age \<18 years old 4. incarcerated individuals will be excluded due to inability to enroll in post-intervention clinic visit 5. presence of posterior glottic stenosis 6. presence of acute laryngeal injury 7. bedside inpatient injection augmentation 8. vocal fold injection with steroids or cidofovir
exercise response in humans with obesity

Conditions: Obese

Summary: this study is being done to understand how chronic inflammation affects muscle function and responses to exercise.


Eligibility criteria:
inclusion criteria: * obese men and women ≥ 20 and ≤ 45 years of age. exclusion criteria: * diabetes or fasting plasma glucose \>126 mg/dl * anemia (female subjects hemoglobin of \<11 g/dl and male subjects hemoglobin \<12 g/dl) * active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment) * renal failure (serum creatinine \> 1.5mg/dl) * chronic active liver disease defined as aspartate aminotransferase (ast)\>144 iu/l or alanine transaminase (alt) \>165 iu/l) * oral warfarin group medications or history of blood clotting disorders. * smoking * pregnancy or breastfeeding * alcohol consumption greater than 2 glasses/day or other substance abuse * untreated or uncontrolled hypothyroidism * debilitating chronic disease (at the discretion of the investigators)
intratendinous genipin injection in horses with tendon injuries

Conditions: Superficial Digital Flexor Tendonitis

Summary: our study is the first to use genipin, a naturally occurring collagen cross-linking agent, as a therapeutic agent to treat superficial digital flexor tendon (sdft) injuries in horses. the promising approach of intratendinous genipin injection and tendon mechanical enhancement could be a viable alternative to current therapies for sdft injuries.

tendon injuries are a career limiting or ending condition in horses. genipin (gp), an exogenous collagen crosslinker, provides ex-vivo tendon mechanical augmentation and excellent biosafety. the main objective of this study is to investigate treatment success of gp-induced collagen crosslinking in a clinical application in horses with superficial digital flexor tendon (sdft) injuries. horses with an aaep (american association of american practitioners) lameness score \> 0 and sonographically confirmed tendinopathy are treated with intratendinous gp injection (igi) and controlled exercise. minimal follow-up was set at 12 months. outcome factors are lameness (aaep lameness score), soundness, assessment of return to previous use, and re-injury. additionally, adverse effects are recorded.

Eligibility criteria:
inclusion criteria: * clinical and sonographic evidence of a tendon injury exclusion criteria: * in the final analysis, only superficial digital flexor tendon injuries were included * if follow-up was less than 12 m due to euthanasia, death or other reasons, horses were excluded from the study
speech and language therapy after stroke

Conditions: Ischemic Stroke

Summary: our overall goal is to advance the state of functional brain imaging in aphasia, and then to apply the method to an intensive, imitation-based treatment for non-fluent aphasia.

detailed information will follow in the next progress report.

Eligibility criteria:
inclusion criteria: 1. single ischemic infarction in the mca territory involving the cerebral cortex (confirmed by ct or mri) 2. aphasia 3. visual attention and language comprehension sufficient to perform imitation fmri tasks 4. right handed (prior to stroke) exclusion criteria: exclusions to the study are people with cardiac pacemakers, claustrophobia, neurosurgical clips, or cognitive impairments too severe to permit cooperation with cognitive tasks in an mri scanner.

Keywords: stroke aphasia imitation mirror neuron
factors associated with mortality, morbidity and prognosis in dementia patients

Conditions: Dementia; Dementia, Vascular; Dementia With Lewy Bodies; Dementia of Alzheimer Type; Dementia Frontal; Dementia, Mixed

Summary: dementia; it is a chronic syndrome characterized by a general and progressive deterioration in cognition, including memory, orientation, language, and comprehension. the prognosis of this progressive and neurodegenerative disease after diagnosis may differ between individuals. in its broadest sense, the prognosis after a diagnosis of dementia; can be defined by shortening of life span, high level of cognitive and functional loss, decrease in quality of life and increased need for care. however, the prognosis of different types of dementia is highly variable. because it is the most common type of dementia, studies are usually on alzheimer's disease. it constitutes 50-75% of total dementia cases. vascular dementia is the second most common cause of dementia and accounts for approximately 15% of dementia cases. dementia with lewy bodies constitutes 10-20% of the total dementia patients and ranks second among degenerative dementia types. frontotemporal dementia, which mimics psychiatric disorders and has prominent behavioural problems, and parkinson's disease-associated dementia, which is characterized by cognitive impairment that can be added to the existing picture in parkinson's patients, are also counted among other types of dementia. prognosis-related data on dementia types other than alzheimer's disease are limited in the literature. determining the prognosis is important to support patients, anticipate long-term health problems, plan physician and healthcare provision, and support patients with dementia.in view of the lack of sufficient data on dementia types other than alzheimer's disease, it is aimed to contribute to the literature on this subject and to determine the factors that may affect prognosis, morbidity and mortality in patients belonging to all dementia types.


Eligibility criteria:
inclusion criteria: having applied to the gulhane training and research hospital geriatrics polyclinic being diagnosed with alzheimer or lewy body dementia or vascular dementia or fronto-temporal dementia or parkinson disease dementia being at the age of 60 years or older exclusion criteria: being under the age of 60 patients with insufficient recorded data and follow-up for the study patients who either have diagnosis or follow-up in another center. patients who have severe dementia that prevents applying for outpatient clinic
rbans-h in older patients before and after cochlear implantation: a protocol for a prospective study

Conditions: Hearing Impaired

Summary: the cognitive profile of older adults with a severe to profound hearing impairment is determined by means of the repeatable battery for the assessment of neuropsychological status, adjusted for hearing impaired subjects (rbans-h) before and after cochlear implantation. in this prospective, longitudinal study the participants are tested preoperatively, at six months and twelve months postoperatively and from then on yearly up to 10 years after implantation. in addition to the rbans-h an audiological examination and an semistructured interview is conducted concerning the cochlear implant use and the self-reliance of the patient and subjective questionnaires are filled out by the subjects to assess quality of life and hearing benefit.


Eligibility criteria:
inclusion criteria: * age: 55 or older * cochlear implant candidate (speech understanding in quiet worse than 60% at 65 decibel sound pressure level (db spl) in the best aided condition)

Keywords: rbans-h cochlear implantation cognition older adults rbans
institutional registry of hip fracture in the elderly

Conditions: Hip Fracture

Summary: the purpose of this study is to create an institutional and population-based registry of hip fracture in the elderly with a prospective survey based on epidemiological data, risk factors, diagnosis, prognosis, treatment, monitoring and survival.

all patients over 65 years old who are admitted to the orthopedic and traumatology ward diagnosed with hip fracture will be assessed. the generation of the list of potentially evaluable patients will be performed daily. once defined patient inclusion, an intern take oral informed consent and will proceed to complete the crf. cohort will be followed at 3 months and a second follow-up at year. variables to be measured: patient data comorbidities charlson score scales functionality factors prior to the fall medications trauma variables complications mortality

Eligibility criteria:
inclusion criteria: 1. patients over 65 with hip fracture. 2. admission to hiba 3. followed by any health care provider. - exclusion criteria: 1 patient refuses to participate in the registration or informed consent process -

Keywords: hip fracture, elderly
amygdala memory enhancement

Conditions: Brain Diseases; Epilepsy; Memory Disorders; Traumatic Brain Injury; Cognitive Impairment; Post Traumatic Stress Disorder

Summary: the objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories. the project is relevant to disorders of memory and to disorders involving affect and memory, including traumatic brain injury and post-traumatic stress disorder.

direct electrical stimulation (des) of the basolateral complex of the amygdala (bla) can improve declarative memory, reflecting the role of the bla in modulating memory processes in medial temporal lobe (mtl) regions as a function of emotional arousal. thus, des can reveal mechanisms of bla-mediated memory enhancement relevant to human mental health and disease. des of the bla can be used to interrogate the function of memory circuits, especially how neuronal oscillations in the mtl support declarative memory. first, bla is hypothesized to wield the capacity to prioritize long-term retention of information initially encountered adjacent in time over days and weeks after encoding. second, the bla preferentially projects to anterior mtl regions and thus is hypothesized to preferentially modulate memory processes in those anatomic regions, processes thought to support memory for non-spatial items more so than memory for spatial locations. third, although emotional arousal, amygdala activity, mtl activity, and memory performance are typically correlated, the investigators hypothesize that des will reveal that bla outputs to other mtl regions cause improved memory performance by directly eliciting pro-memory oscillatory states in those networks. the expected outcomes represent a significant advancement for the basic science of normal memory function and significant movement towards novel therapeutics designed to emulate endogenous mechanisms of memory enhancement.

Eligibility criteria:
inclusion criteria: * must be able to understand and speak english. * able to provide informed consent. * diagnosed with epilepsy. * scheduled to undergo long-term intra-cranial video monitoring for seizure onset localization. * must be implanted with intracranial depth electrodes to the left or right amygdala, hippocampus, and parahippocampal/perirhinal cortices. exclusion criteria: * unable to understand and speak english. * unable to provide informed consent. * not diagnosed with epilepsy.
study of inspiratory muscle training for patients undergoing esophageal surgery

Conditions: Cancer of Esophagus; Cancer of the Esophagus; Esophageal Cancer; Esophagus Cancer; Esophagus Neoplasm; Neoplasms, Esophageal

Summary: to obtain definitive evidence for the effectiveness of a short preoperative inspiratory muscle training (imt) protocol on the morbidity and recovery from an esophageal surgical resection.


Eligibility criteria:
inclusion criteria: * all patients diagnosed with esophageal cancer and scheduled for esophageal resection at the mayo clinic rochester with gastric conduit reconstruction -cognitively capable to understand and perform a preoperative program * able to follow the intervention program for at least 2 weeks before surgery (surgery is usually scheduled 4 to 12 weeks after radiation) * willing to sign the informed consent form exclusion criteria: * unable to communicate in the english language * participating in a conflicting trial concerning esophageal resection

Keywords: rehabilitation inspiratory muscle training
the effect of anti-viral drugs used in late pregnancy on long-term development of children

Conditions: the Safety of Anti-viral Drugs Used in Late Pregnancy

Summary: mother to child transmission(mtct) is the main route of hepatitis b virus(hbv) transmission.high hbv dna level of pregnant women is the main risk factor of mtct. many literatures demonstrate that using nucleoside (acid) analogs in late pregnancy can significantly reduce hbv dna level and effectively blocking mtct. therefore, treatment guidelines of hepatitis b in europe and the asia pacific region clearly pointed out: nucleoside (acid) analogs can be used in pregnant women after 28 weeks of gestation for blocking mtct in mothers with high hbv dna level. at present, the drugs used in late pregnancy including lamivudine (lam) ,telbivudine(ldt) and tenofovir(tdf). the safety of nucleoside (acid) analogues used in late pregnancy on children is not clear.in most of the related researches,the observation termination was 7-12 months after birth, and most were concentrated on the blocking effect of mtct.the long-term impact of nucleoside (acid) analogues on children's development has not been reported in the literatures. the aim of this study is to make clear of the effect of nucleoside (acid) analogues used in late pregnancy on long-term impact of children's development. the one year old children born in beijing ditan hospital and whose mothers had taken lam,ldt or tdf during late pregnancy will be enrolled as study group, and eligible children whose mothers untreated will be enrolled as control group. the children's height, weight, nutritional status, developmental quotient and immune response to hepatitis b vaccine etc will be evaluated at baseline and at 3 years old. by comparing the children's development in different groups as well as in self-control of different ages, we will discuss the effect of nucleoside (acid) analogues on children's long-term development.


Eligibility criteria:
inclusion criteria: * the one year old children whose mothers had taken lamivudine,telbivudine or tenofovir in late pregnancy(28-30 weeks of gestation); * the one year old children whose mothers untreated in late pregnancy; * children had completed standard hepatitis b vaccine and hepatitis b immune globulin combined active and passive prophylaxis; * hbv dna level of the children's mothers were over 6.0 log10 iu/ml before 28 weeks of gestation. exclusion criteria: * children whose mothers over 35 years old at delivery; * the couple having family hereditary disease or abnormal malformation has been found at fetal screening before 28 weeks gestation; * history of amniocentesis during pregnancy; * co-infection with either hepatitis c virus, hepatitis d virus, human immunodeficiency virus, syphilis, toxoplasmosis, rubella or cytomegalovirus. * complications of pregnancy-induced hypertension, premature rupture of membranes, preterm birth, placenta previa or placental abruption; asphyxia at birth.

Keywords: hepatitis b virus pregnancy nucleoside (acid) analogs children safety
combination of olmesartan and hydrochlorothiazide in essential hypertension

Conditions: Essential Hypertension

Summary: the study will evaluate the blood pressure lowering effects of two different dosages of the combination of olmesartan and hydrochlorothiazide in patients with moderate or severe high blood pressure.


Eligibility criteria:
inclusion criteria: * male or female europeans aged 18 years or older with moderate to severe htn, defined as follows (conventional bp measurements) exclusion criteria: * female patients of childbearing potential pregnant, lactating or planning to become pregnant during the trial period. * patients with serious disorders which may limit the ability to evaluate the efficacy or safety of the study medication, including cerebrovascular, cardiovascular, renal, respiratory, hepatic, gastrointestinal, endocrine or metabolic, haematological or oncological, neurological and psychiatric diseases. * patients having a history of the following within the last six months: * myocardial infarction, * unstable angina pectoris, * percutaneous coronary intervention, * severe heart failure, * hypertensive encephalopathy, cerebrovascular accident (stroke) or * transient ischaemic attack. * patients with clinically significant abnormal laboratory values at screening. * patients with secondary htn.

Keywords: moderate-to-severe hypertension essential hypertension combination therapy fixed-combination dose
medical vs surgical treatment in osa among children

Conditions: To Evaluate PSQ as Clinical Tool in the Decision Between Medical and Surgical Treatment for Adenotonsillar Hypertrophy; To Determine Clinical Response to Montelukast or Nasal Steroids Based on PSQ Results

Summary: adeno-tonsillar hypertrophy causing osa are treated surgically however, over the last years it has been shown that montelukast or nasal steroidal spray can significantly improve symptoms, adenoid size, and polysomnographic results in pediatric non-severe osa, excluding the need for surgery. a literature review from 2016 suggested that by using anti-leukotrienes as anti-inflammatory appears to be beneficial in children with a non-severe osa and can be offered to parents as a treatment option before, or instead of surgery. in addition, nasal steroidal spray may be considered useful in decreasing adenoid pad size and the severity of symptoms related to adenoidal hypertrophy \[9\]. despite emerging evidence that both montelukast and nasal steroids are effective in the treatment of pediatric sdb, further evidence is still required. . adeno-tonsillar hypertrophy causing osa are treated surgically however, over the last years it has been shown that montelukast or nasal steroidal spray can significantly improve symptoms, adenoid size, and polysomnographic results in pediatric non-severe osa, excluding the need for surgery. a literature review from 2016 suggested that by using anti-leukotrienes as anti-inflammatory appears to be beneficial in children with a non-severe osa and can be offered to parents as a treatment option before, or instead of surgery. in addition, nasal steroidal spray may be considered useful in decreasing adenoid pad size and the severity of symptoms related to adenoidal hypertrophy. despite emerging evidence that both montelukast and nasal steroids are effective in the treatment of pediatric sdb, further evidence is still required.


Eligibility criteria:
inclusion criteria: * children between 2-16 years of age referred to the pediatric otolaryngology outpatient clinic due to osa and have not undergone previous adeno-tonsillar procedure exclusion criteria: * children with severe osa who need an urgent surgery and cannot be postponed, children with nasal polyposis, craniofacial malformations (e.g. cleft lip and palate), and genetic diseases (e.g. down syndrome).