serum level of ferritin and d-dimer and the severity of (covid 19) infection

Conditions: COVID-19

Summary: many laboratory biomarkers were used for diagnosis of covid-19 infection; however, their accuracy to assess the severity and prognosis are still to be evaluated. aim: to correlate between the serum ferritin and d-dimer levels and the severity of covid-19 infection and its outcome (mortality, days of hospital stay, icu admission or mechanical ventilation). a retrospective study conducted by retrieving patients' data who were admitted to ain shams university specialized hospital - obour branch and diagnosed with covid-19 infection in the period from 1st of april 2020 to 31st of july 2020.

aim of the study: to correlate between the serum level of ferritin and d-dimer and the severity of covid-19 infection as well as its outcome material and methods: it is a retrospective study conducted by retrieving data of patients diagnosed with covid-19 infection "pcr positive for sars-cov2" who were admitted to ain shams university specialized hospital - obour branch in the period from 1st of april 2020 to 31st of july 2020. the following data were collected from the studied patients' files: • demographic characteristics (age, sex, marital status, smoking status, co-morbidities), source of infection, degree of severity of covid-19 infection according to who clinical management of covid-19: interim guidance. the investigations done include: laboratory investigations: including; (complete blood picture, iron profile, liver function tests, d-dimer ("using: using biomerieux-vidas, serial number ivd3002806, manufactured in 2008, marcy l'étoile, france " "reference range: 0-500 ng/ml") and serum ferritin ("using abbot-architect 1000, serial number i1sr62514, manufactured in 2010, chicago, illinois, united states.""reference range: 13-150 ng/ml" (figure number "2") radiological investigations: by high resolution ct chest ("using: toshiba 16-slice ct scanner, model number: activion 16, manufactured in 2010, japan") "severity scoring was done using "25-point ct severity score" li et al, 2020". score of 7 or less was considered as mild affection, 8-17 was considered as moderate affection and 18 or more was considered as severe affection " saeed et al 2021" inclusion criteria: hospitalized isolated patients "in ain shams university specialized hospital - obour branch" with covid-19 infection confirmed by "polymerase chain reaction (pcr) positive for sars-cov2". exclusion criteria: * covid-19 patients with other conditions altering the serum ferritin level; for example; iron deficiency anemia, defective intestinal absorption, internal bleeding, rheumatoid arthritis, hyperthyroidism, leukemia, hodgkin's lymphoma, frequent blood transfusions and advanced liver disease "child-pugh score c". * covid-19 patients with other conditions altering the serum d-dimer level; for example; known pulmonary embolism, known deep venous thrombosis "dvt", pregnancy, heart failure, trauma, active malignancy, septicemia, disseminated intra-vascular coagulopathy "dic". * the patients with any missing studied data were also excluded. data was correlated with the clinical spectrum of severity and the patient outcome regarding: death or recovery, days of hospital stay, need for icu admission and need for mechanical ventilation.

Eligibility criteria:
inclusion criteria: * hospitalized isolated patients "in ain shams university specialized hospital - obour" with covid-19 infection confirmed by "polymerase chain reaction (pcr) positive for sars-cov2". exclusion criteria: * • covid-19 patients with other conditions altering the serum ferritin level; for example; iron deficiency anemia, defective intestinal absorption, internal bleeding, rheumatoid arthritis, hyperthyroidism, leukemia, hodgkin's lymphoma, frequent blood transfusions and advanced liver disease "child-pugh score c". * covid-19 patients with other conditions altering the serum d-dimer level; for example; known pulmonary embolism, known deep venous thrombosis "dvt", pregnancy, heart failure, trauma, active malignancy, septicemia, disseminated intra-vascular coagulopathy "dic". * the patients with any missing studied data were also excluded.