Kornimate/medical-research-clean huggingface dataset:
the development of an eating laboratory for overweight adolescents

Conditions: Adolescent Obesity

Summary: the purpose of the study is to develop methods to evaluate the eating behavior of adolescents, including overweight, normal weight, and candidates for adolescent bariatric surgery.

the purpose of this study is to examine the eating behavior, meal-related perceptions and meal-related hormones in overweight adolescents, normal weight adolescents and overweight adolescents who are undergoing bariatric surgery. subjects will be asked to consume a single-item breakfast meal of a fixed amount (ensure) and a multiple-item meal from a luncheon buffet. during the single-item meal, subjects will fill out questionnaires assessing subjective responses to the meal (e.g. hunger, fullness, pleasantness) and blood samples will be taken before, during, and after the meal to assess hormonal responses to the meal. the multiple-item meal will permit an assessment of total caloric consumption, food and macronutrient choice and rate of eating. overweight adolescents undergoing bariatric surgery will be asked to do the meal studies 1 to 3 months before and 3 to 6 months after their surgery. some bariatric surgery patients will only be studied after their after their surgery. the data gathered from these pilot subjects will be used to further develop and refine our future studies on assessing eating behavior in overweight adolescents.

Eligibility criteria:
inclusion criteria: * bmi index enrollment in bariatric surgery program ages 12-18 exclusion criteria: * pervasive developmental or psychological disorder current use of weight loss medication clinically significant medical condition pregnancy food allergy to single-item meal

Keywords: adolescent obesity bariatric surgery eating
efficacy and safety of duloxetine among individuals with depressive disorder in a 12 weeks trial

Conditions: Major Depressive Disorder

Summary: the aim of this study was to investigate the effects of duloxetine on improvement of brain cortical activity in patients suffering from major depressive disorder using near infrared spectroscopy.


Eligibility criteria:
inclusion criteria: * hamd-17 more than 12 points * participants could understand this study and sign permit * participants could receive nirs measurements * participants could comply with the protocol of the study exclusion criteria: * alcohol or substance abuse within 3 months of the study * ever participate other clinical study related to duloxetine * previous poor treatment effects of duloxetine * concomitant use of maoi within 14 days * concomitant use of linezolid * with uncontrolled glaucoma

Keywords: near infrared spectroscopy, nirs, duloxetine
improving pediatric asthma care through inhaled steroids in schools

Conditions: Asthma

Summary: asthma is the most common chronic pediatric disease in the united states, and is the most common cause of school absenteeism due to a chronic disease. socioeconomically disadvantaged minority children receive disproportionately poor asthma care and incur a disproportionate share of asthma-related morbidity. the district of columbia is particularly severely affected, with a lifetime asthma prevalence rate among children 0-17 years of age in 2010 of 22%, more than double the national average. one of the major challenges in treating asthma is poor adherence to daily controller medications, particularly inhaled corticosteroids (ics) which are the cornerstone of the nih guidelines for asthma management. in an attempt to overcome poor compliance, investigators in rochester, new york have partnered with primary care providers in their community to arrange for ics administration at school by school nurses, and this approach yielded significant improvements in several asthma outcomes. the investigators propose to collaborate in a pilot research project with the overall goal of improving asthma outcomes through reducing barriers to medication adherence. specifically, the investigators aim to improve adherence to controller medications (inhaled corticosteroids - ics) among dc children with asthma through the following activities: 1. a pilot prospective randomized clinical trial of home vs. school administration of ics among dc children in grades kindergarten-8 with persistent asthma. 2. qualitative interviews with nurses from dc public and public charter school to identify key barriers to administration of daily controller medications in the school setting


Eligibility criteria:
inclusion criteria: * current enrollment in one of the grades k-8 at a dc public school (dcps) or dc public charter school (dcpcs) * active public insurance * persistent asthma * an asthma action plan including daily ics * child's primary asthma caregiver present, meaning the person who usually takes care of his/her asthma at home and can answer questions about his/her medical history. exclusion criteria: * chronic disease of the cardio-pulmonary system other than asthma * non-english speaking parent/guardian * currently enrolled in in another asthma study

Keywords: asthma inhaled corticosteroids school nurses
water and the gastropressor response - diurnal variability

Conditions: Orthostatic Hypotension

Summary: we will test the null hypothesis that there is no diurnal (morning to afternoon)variability in the blood pressure response to the ingestion of water 16 oz.


Eligibility criteria:
inclusion criteria: * orthostatic intolerance exclusion criteria: * pregnancy

Keywords: water orthostatic hypotension blood pressure
the effect of triflusal on peripheral microcirculation dysfunction

Conditions: Vasospastic Syndrome

Summary: to explore the efficacy of triflusal in patients with symptomatic peripheral microcirculation dysfunction. triflusal is a salicylate compound approved in several countries as antithrombotic agent and it additionally has vasodilatory effect. the hypothesis is to explore if there is a improvement of peripheral microcirculation by triflusal.


Eligibility criteria:
inclusion criteria: * between 40 and 70 years of age * diagnosed vasospastic syndrome with nailfold capillaroscopy (fingertip is subjected to carbon dioxide at -15°c for 60 seconds. people found to have a blood-flow standstill of at least 12s in one or more capillaries were defined as having vasospasticity) * more than seven points in 10-question interview provided by nagashima et al. * written informed consent exclusion criteria: * prior documented diabetes * overt peripheral artery disease * pregnant or nursing * bleeding tendency * any contraindication of antiplatelet agent * thrombocytopenia (platelet \< 100,000mm3) * chronic liver disease (alt \> 100 iu/l or ast \> 100 iu/l) or renal dysfunction (creatinine \> 4.0 mg/dl) * patients who can not stop to take aspirin

Keywords: vasospastic syndrome vascular dysregulation
the effect of virtual reality therapy on balance and knee control in stroke patients

Conditions: Chronic Stroke

Summary: the aim of study is to determine whether the virtual reality training applied in addition to the exercises given inside and outside the parallel bar is effective on balance, daily living activities and knee control in stroke patients. the hypotheses of the study are: hypothesis 1: h0: virtual reality training has no effect on balance in stroke patients. h1: virtual reality training has an effect on balance in stroke patients. hypothesis 2; h0: virtual reality training has no effect on activities of daily living in stroke patients. h1: virtual reality training has an effect on daily living activities in stroke patients. hypothesis 3; h0: virtual reality training has no effect on knee control in stroke patients. h1: virtual reality training has an effect on knee control in stroke patients

in recent years, virtual reality systems are widely preferred technology-assisted rehabilitation methods due to the many advantages they provide in stroke rehabilitation. virtual reality increases the quality of movement and functional capacity both by providing a sensory environment and by motor learning.

Eligibility criteria:
inclusion criteria: * being between the ages of 18-70 * having a stroke for the first time * patients who can stand and walk independently exclusion criteria: * having neglect syndrome * being bilaterally affected * botulinum toxin application in the last three months * having additional neurological diseases such as parkinson's, multiple sclerosis

Keywords: virtual reality stroke knee hyperextension gait analysis activities of daily living balance
a study of taspoglutide in patients with inadequately controlled diabetes mellitus type 2 and cardiovascular disease

Conditions: Diabetes Mellitus Type 2

Summary: this randomized, double-blind, placebo-controlled parallel arm study will assess efficacy and safety and the effects of taspoglutide on cardiovascular events in patients with inadequately controlled type 2 diabetes mellitus and established cardiovascular disease. patients will be randomized to receive either taspoglutide subcutaneously (sc) 10mg weekly for 4 weeks followed by 20mg sc weekly, or weekly sc placebo, in addition to background anti-hyperglycemic medication and standard of care treatment for cardiovascular disease. anticipated time on study treatment is up to 2 years. target sample size is 2000 patients.


Eligibility criteria:
inclusion criteria: * adult patients, \>18 years of age * diabetes mellitus type 2 * hba1c \>/=6.5% and \</=10% at screening * bmi \>/=23kg/m2 * cardiovascular disease with onset \>/=1 month prior to screening exclusion criteria: * diagnosis or history of type 1 diabetes or secondary forms of diabetes * acute metabolic diabetic complications within past 6 months * severe hypoglycemia \</=1 month prior to screening * clinically significant gastrointestinal disease * history of chronic or acute pancreatitis * current new york heart association (nyha) class iv heart failure or post-transplantation cardiomyopathy * severely impaired renal function
challenges of hip fracture care in developing countries. experience at a level 3 center in panama

Conditions: Hip Fractures

Summary: an observational study using the information records at the hospital regional rafael hernandez, in chiriqui, panama, that will help to analyze the epidemiology and early treatments results of hip fracture patients treated in this institution.

hip fractures are a major public health concern due to increasing ageing of the population, rising costs and associated morbidity and mortality. the problem is more serious in developing countries, because of limited economic and technical resources available. the aim of the following study is to analyze the epidemiology and early treatment results of hip fracture patients treated in our unit. this study will be done at the hospital rafael hernandez regional hospital, a third level facility located in the province of chiriqui, republic of panama. it is a retrospective observational study. for this the study will use the hospital records, including imaging studies were reviewed, including the singh index, and all relevant data will be analyzed with spss 21 software.

Eligibility criteria:
inclusion criteria: * all hip fractures exclusion criteria: * all other fractures and no recorded survey

Keywords: hip fracture trochanteric fracure subtrocantheric fracture femoral head fracture epidemiology
campylobacter enteritis and pi-bd: dietary reduction in carbohydrates

Conditions: Post-infective Bowel Dysfunction; Functional Gastrointestinal Disorders

Summary: the purpose of the study is explore the issues that relate to testing a particular dietary treatment, the low fodmap diet, in a randomised trial using an appropriate control diet with which to compare it. in this trial the investigators will look at its effect on symptoms of people with persistent disturbance in their bowel pattern 3 months after an intestinal infection with campylobacter. the investigators will also look at the changes in gut bacteria that occur with the diet.


Eligibility criteria:
inclusion criteria: * participation in the ceramic study (see linked protocol) * on-going post infective bowel dysfunction (pi-bd) 3 months after confirmation of campylobacter spp. in stool sample. this is defined as responding 'no' to the question "have your bowels returned to normal since your campylobacter infection?" * will consent to use of data and samples acquired for ceramic in the analysis of cedric exclusion criteria: as for ceramic study (so already confirmed) * pregnancy declared by the candidate * history declared by the candidate of pre-existing gastrointestinal disorder, including but not limited to: inflammatory bowel disease; coeliac disease; pancreatitis; gallstone disease (biliary colic, cholecystitis); diverticulitis; cancer of the gastrointestinal tract; irritable bowel syndrome * reported history of previous resection of any part of the gastrointestinal tract other than appendix or gallbladder * intestinal stoma * habitual use of opiate analgesics likely to alter bowel function e.g. morphine * use of antibiotics in the preceding four weeks other than for treatment of index infection. any condition where the candidate is likely to require a course of antibiotics in the next 3 months e.g. severe chronic respiratory disease, recurrent urinary tract infection, lower limb ulceration * inability to complete the symptom questionnaires e.g. cognitive dysfunction, limiting memory and understanding * anyone who in the opinion of the investigator is unlikely to be able to comply with the protocol e.g. cognitive dysfunction, chaotic lifestyle related to substance abuse addition criteria for cedric study: * use of antibiotics or prescribed probiotics during the ceramic study * failure to provide research stool samples during ceramic study * dietary practice not compatible with safe implementation of the trial diet e.g.veganism * medical reasons for pre-existing controlled diet that cannot be safely randomised e.g. end-stage kidney disease, diabetes

Keywords: fodmaps microbiota oligofructose ibs irritable bowel syndrome
written exposure therapy for posttraumatic stress disorder

Conditions: Posttraumatic Stress Disorder

Summary: although evidence-based treatments for ptsd exist, a significant minority of individuals do not benefit from these treatments and many individuals to not seek treatment, citing barriers such as time commitment and expense of treatment. the goal of the proposed study is to establish an alternative ptsd treatment that is efficacious and efficient.

prior research has demonstrated that written exposure therapy (wet), is an efficient, well-tolerated, and efficacious treatment for ptsd. the proposed project takes the next step in establishing wet as an intervention for ptsd by examining whether wet is equally efficacious to an evidence-based treatment for ptsd. using a randomized noninferiority controlled trial, 126 adults diagnosed with ptsd will be assigned to either wet or cognitive processing therapy (cpt). outcome data will be collected at baseline and 6-, 12-, 24-, 36- and 60-weeks post-first treatment session. the primary aim is to examine whether ptsd participants assigned to wet demonstrate ptsd symptom severity outcome that is noninferior to ptsd participants assigned to cpt. secondary aims include examining whether expected treatment gains are sustained for both treatments and whether wet has a lower treatment dropout rate relative to cpt. exploratory aims include examining moderators and mediators of wet and cpt. if the hypothesis that wet is noninferior to cpt is confirmed then a brief treatment option for ptsd will be established.

Eligibility criteria:
inclusion criteria: * ptsd diagnosis * if taking psychotropic medication, on stable dose for 2 months * ability to read and write in english exclusion criteria: * not currently engaged in active ptsd treatment * no current diagnosis of substance dependence * no current diagnosis of psychosis

Keywords: ptsd exposure treatment clinical trial trauma
ultrasound-guided modified transversus thoracic muscle plane block and erector spinal muscle plane block in heart valve replacement surgery with median incision

Conditions: Anesthesia

Summary: sternum midline incision can offer better view under open-heart surgery and bigger operating space, and therefore it has been widely used in most cardiac surgery. if an event of urgency occurs, it takes on a more important role than infrasternal small incision. however, sternum midline incision may cause serious pain and aggravates stress response, and therefore patients are often reluctant to cooperate to cough which exerts adverse effect on postoperative rehabilitation, and even causes serious complications such as pulmonary inflammation, myocardial infarction and heart failure. thus, the relief of pain and better perioperative analgesia are very important for these patients. transversus thoracic muscle plane(ttmp) block and erector spinal muscle plane(esp) block are used in open heart surgery currently, and they can provide good analgesia. this study aimed to investigate the hemodynamic stability, total amount of analgesic use, perioperative pain, stress response, postoperative complication and recovery in patients receiving tmp and esp.


Eligibility criteria:
inclusion criteria: * patients (18-75 years) with bmi at 18-25 kg/m2, asa ⅱ- ⅲ and nyha ⅱ-ⅲ who scheduled to undergo mitral valve or aortic valve replacement surgery. exclusion criteria: * a second operation, preoperative ejection fraction (ef) \< 40%, complicated coronary heart disease, intra-aortic balloon counterpulsation (iabp) support, psychiatric abnormalities, history of allergy to anesthetic drugs, liver or kidney dysfunction, coagulation abnormality, endocrine system diseases and metabolic diseases.
oral selenium therapy for the prevention of mucositis

Conditions: Mucositis; Hematopoietic Stem Cell Transplantation

Summary: selenium as an antioxidant and anti-inflammatory agent could be effective in prevention of mucositis induced by chemotherapy and radiotherapy. other agents such as vitamin e, zinc sulfate, amifostine, beta carotene and benzidamine are indicated for prevention of mucositis and positive effects are seen. our purpose in this double blinded randomized study is to evaluate the selenium effect on mucositis prevention in patient with acute myeloid leukemia (aml) \& acute lymphoblastic leukemia (all) whose received busulfan and/or cyclophosphamide before hematopoietic stem cell transplantation (hsct).

patients with aml or all diagnosis, candidates for high dose chemotherapy with stem cell transplantation will be screened for enrollment in the study. patients will be randomized in two groups with balanced block randomization method. one group will receive selenium tablet twice per day and another group will receive placebo two times per day.therapy will start on the morning before starting chemotherapy and will continue until the first of either discharge day or day +21. response assessment will include: 1. mucositis assessment using who grading and omas scores- to be done from baseline and until day +21 or discharge day if before day +21. 2. evaluation of selenium and glutathione peroxidase levels in the serum, - to be done at baseline, day +7 and day +14. 3. collection of clinical outcome data regarding infectious complications including- presence and length of febrile neutropenia, use of antibacterial and antifungal medications

Eligibility criteria:
inclusion criteria: * patients with aml or all undergoing high dose chemotherapy with stem cell transplantation * adequate renal and hepatic function exclusion criteria: * taking selenium supplement before admission

Keywords: bmt hsct
post-marketing surveillance of long-term administration of inovelon tablets in patients with lennox-gastaut syndrome

Conditions: Lennox-Gastaut Syndrome

Summary: this surveillance's objectives are 1. unknown adverse reactions 2. incidences of adverse drug reaction 3. efficacy during long-term administration 4. factors considered to have effect to safety and effectiveness 5. incidences of status epileptics, skin disorders and hyper sensitivity reaction, and central nervous system-related adverse events(ataxia , somnolence and/or dizzy, etc.)


Eligibility criteria:
all patients with lennox-gastaut syndrome and administrated inovelon

Keywords: epileptic encephalopathy, lennox-gastaut type
effectiveness of high-intensity aerobic interval training on impairments and activity limitations in the acute phase of stroke in benin

Conditions: Stroke, Acute

Summary: this clinical trial aims to examine the effects of combining hiit on a semi-recumbent cycle ergometer (hiit-rce) with conventional physiotherapy on impairments and activity limitations in early subacute stroke. we hypothesized that hiit combined with conventional physiotherapy would be more effective than conventional physiotherapy in improving workload capacity.


Eligibility criteria:
inclusion criteria: people with the diagnosis of stroke were screened and recruited within the first-month after the stroke onset according to the following criteria 1. first episode from an ischemic or hemorrhagic stroke confirmed by ct scan; 2. muscle strength of the affected leg defined by motricity index between 14 and 19, i.e., between 2 and 4 on the medical research council scale; 3. modified ashworth score of 0 or 1, indicating no spasticity or slight spasticity over the affected lower limb, respectively 4. able to walk at least 5 meters independently with or without assistive devices and understand simple instructions; 5. resident in parakou or its surroundings 6. wish to participate in the hospital program exclusion criteria: patients whose medical records reported 1. uncontrolled cardiac arrhythmias (e.g. atrial fibrillation, ventricular tachycardia), heart failure, or recent myocardial infarction, arteriopathy, 2. primary orthopedic conditions (e.g., fractures, active rheumatoid arthritis), 3. other neurological diseases (such as parkinson's disease and alzheimer's disease), (4) patients unable to perform a graded exercise test, i.e., unable to reach the target cadence of 50 rpm or exercise-induced asthma
management of post-delivery pain and its impact on resumption of sexuality

Conditions: Sexuality; Delivery

Summary: study of management of pain and information given to women post-delivery and their impact of the resumption of sexuality. survey to be completed by women at 8 and 15 days and 1 or 3 months after delivery.


Eligibility criteria:
inclusion criteria: * primiparous woman * age between 18 and 45 years old * delivery after 37 weeks of amenorrhea * speaking french * pregnancy, delivery and new-born examination without morphologic or biometric abnormalities, respiratory distress and no pathology discovered at neonatal screening on day 3 * heterosexual woman with partner * signed consent * affiliate of national health insurance scheme exclusion criteria: * multiple pregnancy, * bmi \> 30 * conjugopathie * known psychiatric history * medical history with gynecologic impact * surgery history with gynecologic impacts * hysterectomy post-delivery * protected by french law