Kornimate/medical-research-clean huggingface dataset:
phase 1 study of anti-ox40 in patients with advanced cancer

Conditions: Advanced Cancer

Summary: this study is designed to determine the safety and highest tolerated dose of anti-ox40 in patients with advanced cancer.

this study will evaluate the safety and determine the maximal tolerated dose of anti-ox40; evaluated the immune response to the study treatment; measure the pharmacokinetics of anti-ox40; monitor tumor regression, and identify the most biologically active dose of anti-ox40 to induce antigen-specific responses to a variety of immunogens.

Eligibility criteria:
inclusion criteria: * patients with uncurable metastatic carcinoma, lymphoma, or sarcoma. * ecog performance status 0, 1, 2 * no active bleeding * no clinical coagulopathy * anticipated lifespan greater than 12 weeks exclusion criteria: * active residual toxicity from prior therapies * active infection * hiv positive * hepatitis b or c positive * pregnant or nursing women * requirement for oral steroids * brain metastases * presence or history of autoimmune disease * shellfish or tetanus allergy * splenomegaly * lymph nodes greater than 10 cm in maximal diameter * uncontrolled angina or class ii or iv heart failure

Keywords: metastatic carcinoma lymphoma sarcoma anti-ox40
non-interventional study of long-term treatment of psoriasis with calcipotriol plus betamethasone in gel formulation

Conditions: Psoriasis Vulgaris; Plaque Psoriasis

Summary: the purpose of this observational study is to document the course of disease and relapse management during treatment with daivobet® gel under consideration of patient's individual application habits under daily use conditions.


Eligibility criteria:
inclusion criteria: * patients with light to moderate psoriasis vulgaris of trunk and extremities and treatment with daivobet® gel was planned anyway. * minimum of 3 years diagnosed psoriasis vulgaris. exclusion criteria: * previous therapy with daivobet® gel * systemic therapy of psoriasis vulgaris * contraindications of daivobet® gel in the german package insert * people that are incapable to give free consent

Keywords: psoriasis psoriasis vulgaris plaque psoriasis daivobet® gel germany
characteristics of patients with hypersensitivity reactions to intravenous iron infusions

Conditions: Iron-deficiency; Hypersensitivity Reactions

Summary: this study aims to evaluate characteristics of patients with previous hypersensitivity reaction grades i-iv to intravenous ferric carboxymaltose (ferinject) or to iron sucrose (venofer) including age, atopy status, previous allergic reactions, previous medical history, current medications and co-morbidities. furthermore, symptoms on reaction such as severity grade of reaction will be evaluated.


Eligibility criteria:
inclusion criteria: * participants from 16 years of age and older with previous hypersensitivity reaction grades i-iv to intravenous ferric carboxymaltose (ferinject) or to iron sucrose (venofer). exclusion criteria: * no previous hypersensitivity reaction to iron preparations or reactions to oral iron preparations. * if a rejection to use patient data is documented in patient records, the patient will be excluded from analysis.

Keywords: complement activation-related pseudoallergy (carpa) hypersensitivity reactions (hsr) iron-deficiency non dextran iron preparations (ndips) anemia
long-term extension study of the safety, tolerability, and efficacy of aclidinium bromide in patients with moderate to severe chronic obstructive pulmonary disease (copd) (las-md-36)

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the purpose of this extension study is to evaluate the long-term safety, tolerability, and efficacy of inhaled aclidinium bromide at two dose levels in patients with moderate to severe chronic obstructive pulmonary disease (copd). this study will be 54 weeks in duration; a 52-week double-blind treatment period and 2 week follow-up phone call, following a 12 week lead-in study. all patients will be randomized from the lead-in study at one of two doses of aclidinium.


Eligibility criteria:
inclusion criteria: * completion of a lead-in study (nct00891462) exclusion criteria: * use or anticipated use of any medication prohibited in this study * evidence of abnormal clinical laboratory values, vital signs, or electrocardiographic (ecg) results or the presence of abnormities in physical examination findings * the presence of anti-cholinergic effects (eg, dry mouth, urinary retention, narrow angle glaucoma) * qtcb of \>500 msec on both the pre-dose and post-dose ecg * women who are pregnant, intend to become pregnant, or are breast-feeding * a life expectancy of less than 1 year * noncompliance with ip dosing and/or attending clinic visits during the lead-in study * significant interruption of double-blind therapy during the transition from the lead-in study into the extension study.

Keywords: copd chronic obstructive pulmonary disease chronic bronchitis emphysema airflow obstruction, chronic chronic airflow obstruction chronic obstructive airway disease chronic obstructive lung disease
maxillary anterior teeth and facial index parameters in correlation with recurring esthetic dental proportion

Conditions: There is no Disease the Study Focus on Facial Index in Relation to RED

Summary: the goal of this cross-sectional study is to state the inter relation between anthropometric parameters of pristine maxillary anterior teeth and facial index and their correlation with recurring esthetic dental proportion (red) using 3d digital software (medit) with intra intraoral scanner.the study comprised of 20 adult out patients with an equal number of males and females who had 20-35 years old.

the research focuses on analyzing the proportions of maxillary anterior teeth in relation to facial measurements, particularly within the egyptian population. it evaluates how closely these dimensions align with the recurring esthetic dental (red) proportions, which suggest that the width of anterior teeth should decrease by a constant ratio moving distally. using advanced digital tools such as the bellus 3d face scanner and medit i700 intraoral scanner, the study collected detailed facial and dental measurements from participants to explore the correlation between facial index and tooth dimensions. the sample consisted of 20 participants (10 males and 10 females), with data analyzed using statistical methods to assess symmetry and gender variations in these proportions.). moreover the results were statistically analyzed using the independent t-test or an equivalent non-parametric test was used for comparison between the two groups, and the pearson's correlation coefficient (r) test was used for correlating different parameters.

Eligibility criteria:
inclusion criteria: 1. must be in the same age group (20-35). 2. free of systemically disease (gi, d.m., gastric influx). 3. free of facial asymmetry. 4. free of facial trauma or surgeries. 6.normal class 1 occlusion. 7. free from any tooth wear disorder. 8.periodontally healthy without any previous orthodontic treatment. 9. maxillary anterior teeth free from restoration - exclusion criteria: 1. history of surgery in the anterior maxillary or mandibular region. 2. restorations in anterior sextant. 3 pregnant or lactating females. 4. gingival hyperplasia. 5. orthodontic treatment. 6. facial asymmetry and clefts 7.smokers patient -

Keywords: red, facial index, teeth measurement
headache provocation of people who are unable to have headache

Conditions: Headache; Healthy

Summary: headaches are extremely common illnesses with a combined lifetime prevalence of 90-99% in europe. despite this high prevalence, there are persons who have never, in their whole life, encountered a headache. the aim of the study is to identify factors that protect against headache by studying headache after provocation in people who never have had a headache (headache resistant) versus non-resistant controls. the investigators will use isosorbide mononitrate as a pharmacological trigger of headache. the provocation is performed by investigators who are blinded to the grouping of the participants. the investigators hope to contribute with novelty to the current understanding of headache pathophysiology and development of more efficient treatment of headache.


Eligibility criteria:
inclusion criteria: * headache resistant and non-resistant male participants from the danish blood donor study. * weight: 45 kg to 95 kg exclusion criteria: * daily consumption of any medication. * consumption of any medication less than 12 hours prior to the study day. * headache on the study day or 48 hours prior to the study day. * amnestic or clinical signs of hypertension (systolic blood pressure \>150 mmhg and/or diastolic blood pressure \>100 mmhg) or hypotension (systolic blood pressure \<90 mmhg and/or diastolic blood pressure \<50 mmhg). * any severe cardiovascular disease, including cerebrovascular illness. * amnestic or clinical signs of current mental illness. * amnestic or clinical signs of current substance or drug abuse. * amnestic or clinical signs of any illness the responsible doctor considers relevant for participation in the study.
dotatate pet for meningioma radiation planning

Conditions: Meningioma

Summary: 68ga-dotatate-based radionuclides are a novel modality in the diagnosis and treatment of central nervous system meningioma. dotatate is a ligand for the sstr (somatostatin receptor), which is expressed in meningioma but not in normal brain or bone. it is also more effective than mri in delineating tumor, which is the current imaging standard for assessing meningioma. for radiation planning, it can help to reduce the risk of geometrical miss, identify area that require dose-escalation, and reduce dose to normal tissue. the purpose of the study is to compare the radiation therapy (rt) contouring and planning for meningioma with and without the use of 68ga-dotatate-pet


Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * able and willing to comply with the study procedures * intact meningioma requiring definitive radiation * post-operative meningioma requiring adjuvant radiation * no prior radiation therapy or medical therapy directed at the tumour exclusion criteria: * breastfeeding or pregnancy * claustrophobia or inability to lie still in a supine position * unwillingness or inability to provide informed consent
neoadjuvant chemotherapy compared with surgery for esophageal carcinoma

Conditions: Esophagus Cancer

Summary: most escc received nac in china without supportive evidence from local rcts. the negative conclusion about nac originated from western countries in the 1990s. whether two-field extensive mediastinal lymphadenectomy and paclitaxel/platinum-based chemotherapy results in better survival should be determined. as the highest escc incidence area worldwid, we tried to analyze this top with big data by using a single-center case-control retrospective pms study. paclitaxel- and platinum-based nac combined with two-field of the extensive mediastinal lymphadenectomy might provide better survival benefits than primary esophagectomy for stage ii/iii scc.

treatment neoadjuvant chemotherapy standard nac comprised 2 cycles. platinum plus paclitaxel or docetaxel was repeated once every 3 weeks. cis-platinum was administered at a total dose of 75 mg/m2 by continuous infusion on d1 or equal divided on days 2-4 or days 1-3. paclitaxel, 175 mg/m2, d1, or paclitaxel, 87.5 mg/m2, d1, d8. if the docetaxel was adopted, it was given as 75 mg/m2 on day 1. surgical procedure at approximately 6-8 weeks after nac, open (mckeown, left thoracic incision left cervical anastomosis) or mie via thoracoscopy and/or laparoscopy was performed in the patients. bilateral laryngeal recurrent nerve lymph node dissection was requested for every patient. comparisons between the nac and primary surgery groups were performed using the chi-square test, mann-whitney u test and fisher's exact test for categorical parameters after pms. kaplan-meier curves and a cox proportional hazards regression model were adopted to perform os analysis.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of esophageal squamous cell carcinoma(escc) at henan cancer hospital between january 1, 2015, and december 31, 2018 and the data was prospectively collected in the hubble of the linkdoc data company * surgery performed in the thoracic surgery department * no previous cancer treatment exclusion criteria: * patients with secondary cancer were excluded
genetic test to identify previously undetectable minimal residual disease in cell samples from younger patients with acute lymphoblastic leukemia

Conditions: Leukemia

Summary: rationale: testing for minimal residual disease in cell samples from patients with acute lymphoblastic leukemia may help doctors plan better treatment. purpose: this research trial studies a genetic test in identifying previously undetectable minimal residual disease in cell samples from younger patients with acute lymphoblastic leukemia.

objectives: * to identify and characterize changes in clonal populations of b cells in children with acute lymphoblastic leukemia (all) at diagnosis and day 29 of induction. * to define the ability of this technology to reclassify patients as minimal residual disease (mrd) positive at day 29 of induction. * to determine whether more sensitive detection of mrd at day 29 would have clinical prognostic value in children with all. outline: dna extracted from diagnostic cells are analyzed for immunoglobulin heavy chain variable region by next-generation sequencing.

Eligibility criteria:
disease characteristics: * samples from patients enrolled on cog-aall0232 with standard-risk (sr) or high-risk (hr) acute lymphoblastic leukemia (all) with varying levels of mrd and relapse * diagnostic cells and day 29 cells from patients that have not relapsed and are 5 years from diagnosis on protocol cog-aall0232 * diagnostic cells and day 29 cells from patients that are matched for age, sex, initial white blood cell (wbc) count, and cytogenetics that have relapsed patient characteristics: * not specified prior concurrent therapy: * not specified

Keywords: childhood acute lymphoblastic leukemia in remission recurrent childhood acute lymphoblastic leukemia b-cell childhood acute lymphoblastic leukemia
augmented reality for shoulder pain and scapular dyskinesis

Conditions: Shoulder Pain

Summary: the aim of this study is to analyze whether an augmented reality based scapular stabilization exercise program is more effective than conventional programs in patients with chronic shoulder pain and scapular dyskinesis.


Eligibility criteria:
inclusion criteria: * unilateral mechanical shoulder pain of nonspecific origin (non-traumatic) lasting at least 3 months. * weakness in flexion, abduction and/or external rotation isometric strength testing. * presence of scapular dyskinesis according to kibler, scapular assistance test, and scapular reposition test. exclusion criteria: * previous shoulder surgery. * history of shoulder fracture or glenohumeral luxation. * history of acromioclavicular joint injury. * presence of massive rotator cuff rears. * presence of frozen shoulder. * cervical hernias or radiculopathy. * fibromyalgia. * neuropathic pain. * cervical and/or vestibular problems with dizziness, unsteadiness, or vertigo. * medical contraindication for performing exercise (cardio-vascular or cardio-pulmonar diseases, systemic diseases, metabolic diseases in non-controlled acute state). * blindness. * actually being treated with physical therapy for shoulder pain.
multimodal model predicts recurrence

Conditions: Gastric Adenocarcinoma

Summary: this study focuses on developing an advanced model that combines clinical information, imaging, and pathology data to predict the likelihood of cancer returning after surgery in patients with locally advanced gastric cancer. by using artificial intelligence (ai), this model analyzes various data sources to create a more accurate prediction of recurrence risk, which can help doctors, patients, and families better understand the chances of recurrence. this ai-driven approach allows healthcare providers to make more informed decisions about personalized follow-up care and potential additional treatments to improve patient outcomes.


Eligibility criteria:
\*\*inclusion criteria:\*\* * patients diagnosed with locally advanced gastric cancer (stage ii or iii). * patients who have undergone surgical resection for gastric cancer. * patients with complete clinical, imaging, and pathology data available for analysis. * age 18 years or older. * patients who provide informed consent to participate in the study. \*\*exclusion criteria:\*\* * patients with distant metastasis (stage iv) at the time of diagnosis. * patients with incomplete or missing clinical, imaging, or pathology data. * patients who have received prior treatment for gastric cancer other than surgical resection. * patients with other concurrent malignancies. * patients who are unable or unwilling to comply with the study follow-up requirements.
stimulation of the proprioceptive trigeminocardiac reflex

Conditions: Temporomandibular Joint Disorders

Summary: study over muscular stretching to reduce pain the oral cavity.

it is a current opinion that muscular stretching is able to reduce pain and to allow increase of the opening excursion at the joints. to investigate this possibility in the face, the investigators developed a method of stretching associated with large dynamic jaws during chewing using a special device (spring device ®) for ten minutes, allowing the muscles of the oral cavity to relax. the height of the bite was set as two-thirds of the maximum opening (max. 2 cm.) of the mouth at rest (without forcing) thus avoiding maintaining the head of the condyle at maximum aperture for a long time. the subjects were then analyzed by means of kinesiography to determine the changes in the vertical dimension. increasing stretching produces neuromuscular relaxation and a reduction of pain. this study showed that this therapy induces oral and extraoral pain reduction and increases neck mobility and mouth opening. the stimulation of trigeminal receptors is an important drive for therapy in the trigeminocardiac reflex (tcr).

Eligibility criteria:
inclusion criteria: * all the subjets up to seventy years exclusion criteria: * subjects under eight years

Keywords: mandibular stretching, trigeminocardiac reflex
a study to estimate the effect of repeated dosing of pf-05175157 on the pharmacokinetics of a single dose of simvastatin in healthy adult subjects

Conditions: Type 2 Diabetes Mellitus

Summary: the study is designed to investigate the effect of repeated dosing of pf-05175157 on the pharmacokinetics of a single dose of simvastatin in healthy adult subjects.


Eligibility criteria:
inclusion criteria: * healthy subjects with normal results in all screening examinations. * body mass index of 17.5 to 35.5 kg/m2 exclusion criteria: * evidence or history of clinically significant hematological, renal, endocrine, pulmonary, ocular, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at time of dosing). * known history of intolerance to simvastatin or other statins.
efficacy of 3,4-dap in fatigue associated with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: rational of study : 3,4-diaminopyridine is suspected to improved the fatigue associated in patient's multiple sclerosis. in order to confirm this hypothesis, a randomized, controlled versus placebo, double blinded study is performed.

we proposed a randomized controlled trial between 3,4-diaminopyridine and placebo . the main objective : improvement of fatigue by diminution of emif-sep score between the arm treatment and placebo arm. the hypothesis tested is that the 3,4-dap is efficacy in the fatigue of multiple sclerosis.

Eligibility criteria:
inclusion criteria: * age \>= 18 years and = \<60 years * patients with multiple sclerosis clinically defined and with mifs-sep score \> 44, without deficit sleep and without depression. * patients without treatment by 3,4-dap since 3 months * edss score \< 6 exclusion criteria: * asat/alat \> 2 x uln * madrs \>= 20 * abnormality cardiac rhythm * pregnancy * asthma * evolutive affection * renal failure

Keywords: multiple sclerosis fatigue 3,4-diaminopyridine
comparative study of insulin therapy between inner and outer upper thigh

Conditions: Diabetes Mellitus

Summary: to observe the patient's preference, pain perception, and usability between inner and outer upper thigh for insulin therapy. to add another injection site for insulin therapy.

the most common injection site is the abdomen (or stomach). the back of the upper arms, the upper buttocks or hips, and the outer side of the thighs are also used. these sites are the best to inject into for two reasons: they have a layer of fat just below the skin to absorb the insulin, but not many nerves - which means that injecting there will be more comfortable than injecting in other parts of your body. but while the needle for insulin therapy is becoming shorter, it is possible to inject insulin at the inner thigh site.

Eligibility criteria:
inclusion criteria: * all adult patients more than 18 years age old with diabetes that need insulin therapy exclusion criteria: * those diabetes with psychologic diseases and those patients won't be injected at thigh
optimized treatment strategies for early and medium stage nasopharyngeal carcinoma

Conditions: Stage II, III; Nasopharyngeal Squamous Cell Carcinoma; Induction Chemotheray; Concurrent Chemoradiotherapy; Reduce Treatment Intensity

Summary: the purpose of this study is to optimize treatment strategies for patients with stage ii and iii nasopharyngeal carcinoma, reduce the side effects related to treatment and improve the quality of life.

the data came from conventional studies showed that the distant metastases and toxicities associated with concurrent chemoradiotherapy were main problems for patients with clinical stage ii and iii nasopharyngeal carcinoma. however, inductive chemotherapy can decrease the likelihood of emergence of distant metastasis and reduce treatment related toxicities as previous studies showed. the role of inductive chemotherapy in screening low-risk nasopharyngeal carcinoma for less treatment intensity is under-evaluated in the era of intensity-modulated radiotherapy (imrt). we hope to find the optimized treatment strategies by reducing the intensity of treatment according to the treatment response of inductive chemotherapy.

Eligibility criteria:
inclusion criteria: * pathology confirmed nasopharyngeal squamous cell carcinoma. * aged 18 to 70 years old; * stage ii-iii (t1n1m0，t2-3n0-1m0) diseases according to 8th ajcc staging and the shortest diameter of the largest lymph node involved is no more than 3cm; * kps≥70; * have measurable lesions on ct/mri before treatment; * treatment for the first time; * at least 6 months lifetime was expected; * adequate laboratory indexes, defined as follows: hemoglobin \> 120g/l, wbc \> 4.0x10\*9/l, plt \> 100x10\*9/l \< 2, all indexes of liver and kidney function ≤ 1.25 times of the institutional upper limit of normal value, no hearing loss; * can understand and sign the consent * have follow up condition exclusion criteria: * past malignancies history (except for stage i non-melanoma skin cancer or cervical carcinoma in situ) * previously treatment for cancer * pregnant or breeding woman, female without contraception * enrolling in other drug trials * severe comorbidities including myocardial infarction, arrhythmia, cerebral vascular disease, ulceration disease, mental disease and uncontrolled diabetes * without follow up