Kornimate/medical-research-clean huggingface dataset:
effects of acute exercise on acetylcarnitine concentration in endurance trained and untrained subjects

Conditions: Diabetes Mellitus, Type 2

Summary: it has been suggested that imbalance between tca-cycle flux and β-oxidation may underlie insulin resistance, a predisposing factor for the development of type 2 diabetes mellitus. acetylcarnitine concentration is suggested to be a marker of such imbalance. it is expected that when tca-cycle capacity is high (a high oxidative capacity), less acetylcarnitine will accumulate, because of an improved balance between supply and demand of lipids. the major research objective is to examine if acute exercise results in a more pronounced increase in acetylcarnitine concentration in sedentary subjects compared to endurance-trained subjects and if the exercise-induced increase in acetylcarnitine is restored more quickly in endurance-trained subjects when compared to sedentary subjects. the investigators hypothesize that the increase in acetylcarnitine levels will be lower in trained subjects when compared to sedentary subjects, due to a better balance between lipid supply and utilization by the tca-cycle. furthermore it is expected that acetylcarnitine concentrations will be restored faster in these trained subjects, because of a tighter regulation of influx of fatty acids. to test this hypothesis the investigators want to compare the acetylcarnitine response to exercise in a group of sedentary subjects and a group of endurance trained subjects. this response will be measured for 30 minutes after exercise with the use of 1h-mrs.


Eligibility criteria:
inclusion criteria: * normal weight (bmi 18-25 kg/m2) * healthy * stable dietary habits * no use of medication * vo2-max for trained subjects above 50 ml/min/kg * vo2-max for untrained subjects below 40 ml/min/kg exclusion criteria: * any medical condition requiring treatment and/or medication use or diminishing exercise tolerance * alcohol consumption of more than 20 g per day (± 2 units) * unstable body weight (weight gain or loss \> 3 kg in the past three months) * participation in another biomedical study within 1 month prior to the screening visit * contraindications for mri scan: * central nervous system aneurysm clips * implanted neural stimulator * implanted cardiac pacemaker of defibrillator * cochlear implant * iron- containing corpora aliena in the eye or brain * hearing aids and artificial (heart) valves which is contraindicated for mrs * subjects, who do not want to be informed about unexpected medical findings cannot participate in the study.
cardioneuroablation vs pulmonary vein isolation in treatment of paroxysmal atrial fibrillation

Conditions: Atrial Fibrillation Paroxysmal

Summary: the goal of this study is to compare effectiveness of cardioneuroablation of right anterior ganglionated plexus and pulmonary vein isolation in patients with enhanced vagal tone expressed as deceleration capacity \>7.5ms.

patients included into the study will be randomized to a group undergoing cardioneuroablation (cna) of the right anterior ganglionated plexus (ragp) or pulmonary vein isolation (pvi). in cna group the location of ragp will be determined anatomically below the superior vena cava ostium near the superior-septal aspect of the right atrium. radiofrequency (rf) applications will be delivered and will be continued until heart rate (hr) acceleration \>30% is achieved or if the rf time exceeds 120s. in the pvi group point-by-point rf isolation of all pulmonary veins will be performed. clinical follow-up (fu) will consist of multiple ambulatory visits combined with standard ecg readings and a 7-day holter recording. during fu visits, a detailed history of any palpitations, episodes of atrial fibrillation (af), and hospitalizations for cardiac arrhythmias will be collected.

Eligibility criteria:
inclusion criteria: * paroxysmal atrial fibrillation documented in ecg or holter monitoring * deceleration capacity \>7.5ms * life expectancy more than 1 year * age ≥18 years exclusion criteria: * permanent af lasting more than one year or persistent af lasting more than 7 days * af secondary to electrolyte imbalance, thyroid disease, alcohol abuse, or other non-heart related causes * anteroposterior dimension of the left atrium in the echocardiography ≥43mm * clinically significant arrhythmias other than af * significant valvular disease * valve prosthesis * heart failure iii or iv class in new york heart association classification * previous ablation of atrial fibrillation or atrial flutter * history of a patent foramen ovale/atrial septal defect closure * history of left atrial appendage closure * atrial myxoma * presence of a cardiac pacemaker, defibrillator or cardiac resynchronization therapy device * history of pericarditis * congenital heart disease * history of bleeding or coagulation disorders * contraindications to oral anticoagulation * contraindications to computed tomography or magnetic resonance imaging * pregnancy or breast-feeding * bmi\>31 * history of transplantation * severe lung disease * chronic renal failure defined as estimated glomerular filtration rate (egfr) \<30 ml/min/m2 * cancer * significant infection * life expectancy less than one year * mental disorders * lack of informed consent to participate in the trial

Keywords: atrial fibrillation vagally-mediated cardioneuroablation
clinical experiment of helicobacter pylori transmission

Conditions: Infection; Achlorhydria

Summary: the study proposes to test whether chronic infection with helicobacter pylori protects individuals from symptomatic infection with enteropathogenic e. coli. the study will also evaluate the effect of gastric acidity in this relationship.

because h. pylori is an enteric infection, its prevalence may be linked to exposure to other enteric pathogens. results of observational studies on the association between h. pylori and gastroenteritis, however, have been conflicting. some have shown increased incidence of diarrhea in children with h. pylori infection, with one study attributing 11% of diarrhea cases to h. pylori. other studies found no association, and still others found a protective effect of h. pylori against gastroenteritis. dissecting out confounding from true physiological associations can be difficult in observational studies. to better elucidate the association between h. pylori and gastroenteritis, we performed a direct challenge experiment with a well-characterized gastrointestinal pathogen, enteropathogenic escherichia coli (epec). epec is a leading cause of infantile gastroenteritis in the world and has a long history of safe use in human experiments. it is also acid sensitive: in our laboratory less than 0.001% of inoculated epec organisms survived at ph 2.5. our goal was to test the hypothesis that chronic infection with h. pylori increases the risk of diarrheal illness after direct challenge with epec.

Eligibility criteria:
inclusion criteria:healthy exclusion criteria:prior gastrointestinal disease prior treatment of h. pylori infection immune suppression or deficiency history of cancer, diabetes, or other co-morbidity
use of zolpidem in parkinson's disease

Conditions: Parkinson's Disease

Summary: levodopa treatment is associated with long-term complications. dopamine deficiency is associated with abnormal activity in certain parts of the brain. zolpidem may change this abnormal activity and, by doing so, may work in a different way than levodopa to help parkinsonism. the working hypothesis for this aim is that zlp is superior to placebo in acutely improving motor symptoms of pd. the investigators will conduct a randomized,controlled, double-blind, cross-over study in 40 patients with pd. each patient will receive placebo, levodopa and 2 doses of zlp in a randomized order on 4 different occasions, about one week apart.


Eligibility criteria:
inclusion criteria: * subjects will have idiopathic parkinson's disease according to diagnostic criteria of the united kingdom parkinson's disease society brain bank. * subjects will be capable and willing to provide written informed consent prior to participation. * subjects will be ambulatory (in on- and off-states) men and women, between the ages of 30 and 75 years. * subjects will be on levodopa therapy, with a good response and indisputable motor fluctuations. * all other pd medications are allowed. * subjects will be on a stable regimen of pd medications for 2 weeks prior to screening. * subjects will be required to come with a caregiver who can accompany the subject to/from each study visit. note: subjects will not be allowed to drive home. * female subjects will be advised to use adequate birth control throughout the study as the effects of zlp on the fetus are unknown. adequate birth control methods include surgical sterilization, a partner who has had a vasectomy, oral contraceptives, condom plus spermicidal cream/jelly, cervical cap plus spermicidal cream/jelly, diaphragm plus spermicidal cream/jelly, or intrauterine device (in place for at least 3 months) plus spermicidal cream/jelly. abstinence is considered an acceptable contraceptive regimen. if a subject becomes pregnant during the study, it is important that they contact the study physician immediately. exclusion criteria: * neurodegenerative diseases. * tremor predominant pd, with a score of \> 2 in more than one body part. * inability to tolerate being off levodopa for 12 hours. * a score on the montreal cognitive assessment (moca) of less than 26. * pregnancy or lactation. * history of drug or alcohol abuse. * known or suspected sensitivity to the investigational study drugs. * other known medical or psychiatric condition that may compromise participation in the study or that judged by the site investigator could disqualify a subject from entering the study. * participation in another investigational drug study whereby they received experimental drug \< 30 days prior to start of this study. * subjects who have undergone surgical procedures for pd but otherwise meet inclusion criteria will not be excluded a priori but evaluated on an individual basis.

Keywords: parkinson's disease zolpidem
the influence of internet + combined family empowerment management mode on treatment compliance of patients with ckd

Conditions: Internet; Chronic Kidney Disease

Summary: to explore the effect of internet + combined family empowerment management mode on treatment compliance of patients with chronic kidney disease (ckd) and the correlation between psychological status and disease progression.

to explore the effect of internet + combined family empowerment management mode on treatment compliance of patients with chronic kidney disease (ckd) and the correlation between psychological status and disease progression. a total of 100 patients with ckd treated in our hospital from october 2020 to october 2021 were screened and analyzed, and randomly divided into combined group and traditional group according to the number table method, with 50 patients in each group. the traditional group was implemented with the conventional chronic disease management mode, and the combined group was implemented with the internet + combined family empowerment management mode. the differences in compliance, self-efficacy, psychological status and renal function indexes of each group were compared. mmas-8 compliance score and gses score showed an increasing trend. compared with the traditional group, t2-t4mmas-8 score and gses score in the combined group were significantly increased with statistical differences (p \< 0.05). the levels of bun, scr, sas and sds showed a decreasing trend. compared with the traditional group, the levels of four indexes t2-t4 in the combined group were significantly decreased with statistical differences (p \< 0.05). bun, scr were positively correlated with sas and sds (p\< 0.05). internet + combined family empowerment management model can effectively improve renal function, negative psychological clarity, self-efficacy and medication compliance of ckd patients, which is worthy of clinical promotion.

Eligibility criteria:
inclusion criteria: * enrolled subjects meet the diagnostic criteria for ckd and are confirmed to be ckd based on laboratory findings. * after assessment, it was determined that the subject's communication was barrier-free * no abnormal feedback was found after evaluation. * the patient received dialysis treatment for more than 3 months, and the clinical data were complete. this is the first time they've been to the hospital. exclusion criteria: * the female patient is pregnant and lactating. * kidney transplant patient. * people with language communication disorders or mental diseases. * participants received other psychological guidance and health education interventions during the study period.

Keywords: compliance self-efficacy family empowerment management mental state
the use of eye patches and earplugs in intensive care in cases of craniotomy.

Conditions: Craniotomy

Summary: this study aims to evaluate the effects of using eye patch and earplugs on anxiety, patient comfort, and sleep quality after craniotomy. the study will be carried out in a hospital located in the northwest of turkey. a total of 60 patients meeting the research criteria will be randomized to intervention and control groups. an eye patch and earplug will be applied to the intervention group in the intensive care unit on the day of craniotomy and on the post-operative 1st day between 22:00 and 06:00. standard care procedure will be applied to the control group. richard-campbell sleep questionnaire, aktiwatch, hospital anxiety and depression scale and general comfort questionnaire will be used to collect study data.

this study was designed as a non-drug clinical study with 2 randomly selected groups to evaluate the effect of eye patch and earplug use on sleep quality, anxiety and comfort level in patients hospitalized in the intensive care unit after craniotomy. the study will be carried out in a hospital located in the northwest of turkey. a total of 60 patients meeting the research criteria will be randomized to intervention and control groups. an eye patch and earplug will be applied to the intervention group in the intensive care unit on the day of craniotomy and on the post-operative 1st day between 22:00 and 06:00. standard care procedure will be applied to the control group. richard-campbell sleep questionnaire, aktiwatch, hospital anxiety and depression scale and general comfort questionnaire will be used to collect study data.

Eligibility criteria:
inclusion criteria: * patients scheduled for elective craniotomy and intensive care for at least 48 hours * glasgow coma scale score = 15 * turkish literate exclusion criteria: * diagnosis of sleep disorder * hearing and/or vision loss * hearing aid use * pregnant women * communication and/or cooperation problem * chronic pain medication

Keywords: anxiety sleep intensive care, surgical craniotomy
patient satisfaction and clinical experience of dentists

Conditions: Patient Satisfaction

Summary: rehabilitation of the edentulous patients has always been a challenge. the success of this treatment modality is not only affected by the patients' acceptance of his new dentures, but on his ability to use them which depends to a great extent on the quality of those dentures. it is strongly believed that the success of dental treatments is affected by the experience of a dentist. the aim of this study was to compare patient satisfaction with complete dentures provided by forth and fifth year dental students and prosthodontists at the university of jordan hospital one week and 8 weeks post insertion

after obtaining the ethical approval, questionnaires were distributed to a total of 60 patients who accepted to participate in this study. the 60 patients consisted of 2 groups. the first group included patients treated by fourth and fifth year students, the second group consisted of patients treated by prosthodontists with a minimum of 5 years of experience. the questionnaire was distributed to those patients 8 weeks post insertion of complete upper and lower dentures. the questionnaire was divided into 3 parts. the first part included demographic and contact information questions for the patient. the second part included examination to the upper and lower dental arches and a third part included questions that probed the patient's satisfaction with his upper and lower dentures in general. furthermore, the questionnaire included questions about the patient's comfort with his dentures, whether he is satisfied with the esthetics, phonetics, retention, efficiency in mastication, and ease of cleaning. this part of the survey was adapted from the oral health impact profile (ohip-edent) questionnaire.

Eligibility criteria:
inclusion criteria:the study population was completely edentulous patients attending the undergraduate students' clinic and specialty prosthodontic clinics at the jordan university hospital in need of conventional complete dentures. - exclusion criteria: -

Keywords: complete denture patient satisfaction survey edentulous patients treatment outcomes
relationship between oral health and diabetes

Conditions: Diabetes

Summary: the aim of this study is to assess the state of knowledge and practices in oral health of diabetic patients through the use of two questionnaires. it is also to analyse the link between the oral health status and the profile of diabetic patient, by carrying out an oral assessment for voluntary patients.


Eligibility criteria:
inclusion criteria: - all diabetic patients over 18 coming to the chu lapeyronie exclusion criteria: -non diabetic patients, diabetic patients under 18

Keywords: oral hygiene public health patients coming to the chu lapeyronie for consultation or those being hospitalised there prevention telemedicine
study on integrated nursing strategy for patients with gastrointestinal stromal tumors after targeted therapy

Conditions: Nursing Caries; Gastrointestinal Stromal Tumors

Summary: the goal of this clinical trial is to construct a symptom management strategy for patients with gastrointestinal stromal tumor targeted therapy based on symptom management theory under the guidance of mrc framework. embed the symptom management strategy into the information platform and conduct an empirical study on integrated care for gist patients, and compare it with the traditional outpatient follow-up patients to explore the safety and effectiveness of the symptom management strategy and the application effect of the integrated care platform.

the purpose of this clinical trial is to build an information platform for symptom management and integrated care strategy of gastrointestinal stromal tumor targeted treatment patients: the system is composed of big data platform and care strategy platform. the big data platform can automatically extract patient data from his, medcare and other patient diagnosis and treatment systems according to the pre-set patient inclusion criteria, form a health file of gastrointestinal stromal tumor targeted treatment patients, and complete the enrollment. the system will intelligently promote the care strategies of the patients included in the big data platform, promote the two-way communication between doctors and patients, and realize the functions of timed symptom evaluation, symptom management, symptom management result feedback, etc. all patient health data can be customized output through the big data platform. the two platforms complement each other, promote patient self-management, improve the quality of medical follow-up service, reduce the workload of medical personnel, optimize the use of medical resources, and improve the quality of scientific research data. it is not necessary for patients to judge how to take intervention measures, but the system's management center decision-making module will evaluate the symptoms of patients, and then pop up corresponding measures, so that patients can more effectively cope with the discomfort of related symptoms caused by targeted treatment at home, and alleviate the impact on life.

Eligibility criteria:
inclusion criteria: * patients diagnosed as gastrointestinal stromal tumor and receiving targeted therapy * over 18 years old, with normal communication ability * will use smart phones, or the family members who will use smart phones will live in the meeting * informed consent and voluntary participation in this study. exclusion criteria: * patients with psychiatric history or congenital mental retardation * the patient or his/her cohabiting family members cannot complete the health status self test, health status assessment and questionnaire under the prompts of the platform. criteria for case termination: * those who voluntarily put forward termination during the study period and are unwilling to accept follow-up or refuse to fill in the questionnaire * death * lost subjects
the effect of scapular proprioceptive neuromuscular facilitation techniques on pain and functionality in subacromial impingement syndrome

Conditions: Shoulder Impingement Syndrome

Summary: the aim of this study was to investigate the effects of scapular proprioceptive neuromuscular facilitation (pnf) techniques applied in addition to exercise therapy in patients with subacromial impingement syndrome (sis) on pain, pressure pain threshold (ppt), range of motion (rom), functionality, scapular dyskinesis, active trigger points and emotional state.

32 patients between the ages of 20-60 diagnosed with sis were included in the study. the patients were randomly divided into two groups. the exercise group received an exercise program of 12 sessions. scapular pnf techniques were applied to the pnf group with the same exercise program. patients were evaluated twice; one before and one after 6 weeks of treatment; using visual analogue scale (vas) for pain, algometer for ppt, digital goniometer for range of motion (rom), the disabilities of arm, shoulder and hand (dash) for functional status, lateral scapular slide test (lsst) for scapular dyskinesis, travell and simons criteria for trigger point and hospital anxiety and depression scale (hads) for emotional state. at the end of treatment patient satisfaction was evaluated with global change scale.

Eligibility criteria:
inclusion criteria: * aged between 20 and 60 * diagnosed with sis by mri and clinical examination and a specialist physician * positive impingement tests (hawkings, neer and jobe test) or painful motion arc (60 ° -120 °) * unilateral shoulder pain that has been going on for at least 3 months * signed voluntary consent form exclusion criteria: * diagnosed with adhesive capsulitis or massive rotator cuff tear * having undergone upper limb surgery * presence of rheumatological systemic diseases * presence of glenohumeral instability * having a neurological disease affecting the upper extremity * diagnosed with cervical radiculopathy * degenerative joint disorders * having communication problems * steroid injection therapy or physiotherapy in the past 6 months have been rehabilitated

Keywords: proprioceptive neuromuscular facilitation shoulder pain