Kornimate/medical-research-clean huggingface dataset:
impact of lateral bone grafting with intraoperative fusion in acdf on clinical outcomes

Conditions: Cervical Spondylosis

Summary: the purpose of this trial was to investigate the safety and efficacy of fuser lateral bone grafting in acdf. by observing the intervertebral bony fusion rate and clinical outcome scores of patients after fusion device lateral bone grafting, it was verified whether the fusion device lateral bone grafting approach could improve the bony fusion rate and clinical outcome of acdf.

the study will include patients who underwent 1-2 segment acdf surgery, in addition to conventional surgical operations, the appropriate amount of allograft bone was implanted in the joint space of the hook vertebrae lateral to the fusion device, and x-rays and cts were reviewed in the immediate postoperative period, march, june, and december, to verify intervertebral osseous fusion, as well as to observe the patient's clinical outcomes.

Eligibility criteria:
inclusion criteria: * age between 18-60 years old; patients with cervical spondylosis who were about to undergo 1-2 segment acdf surgery; agreement with the surgical plan and willingness to undergo long-term clinical follow-up; and signing of an informed consent form. exclusion criteria: * drug or alcohol abusers; those with abnormal liver or kidney function unsuitable for surgery; those with cardiac insufficiency unsuitable for surgery; those with severe metabolic and endocrine diseases unsuitable for surgery; those with severe lung disorders such as asthma and abnormal lung function unsuitable for surgery; pregnant and breastfeeding women as well as those who are planning to become pregnant in the near future; those who have participated in other clinical trials within 3 months; and those who are not suitable for participation in the experiment in the opinion of the investigator.
effect of thickened feeds on swallow physiology in children with dysphagia

Conditions: Dysphagia; Aspiration; Brief Resolved Unexplained Event (BRUE); Apparent Life Threatening Event (ALTE)

Summary: this study will examine the effects of varying liquid viscosity on swallow physiology in infants with oropharyngeal dysphagia and brief resolved unexplained event (brue) and other children with dysphagia that would be at risk for symptoms of swallow dysfunction.

infants with oropharyngeal dysphagia and in particular brief resolved unexplained events (brue) are a significant driver of pediatric health care expenditure since the mechanism for their swallow dysfunction is incompletely understood and therefore frequently goes unrecognized and untreated. we hypothesize that infants with oropharyngeal dysphagia and brue have measurable differences in swallowing physiology to explain their symptoms of cyanotic choking spells, that these differences can be quantified using pharyngeal high resolution impedance-manometry compared to videofluoroscopic swallow study results, and that this swallowing dysfunction can be safely corrected with a change of formula viscosity. through this research project, we will systematically investigate the effects of thickened feedings on swallow function in infants with dysphagia and brue and perform detailed physiology studies on pharyngeal and esophageal motility as critical mediators of improved outcomes.

Eligibility criteria:
inclusion criteria: * age 0 to 21 years * admitted to boston children's hospital after experiencing first lifetime brue, or with dysphagia symptoms such that they would be at risk for brue or other symptoms of swallowing difficulty * have had videofluoroscopic swallow study performed or might have future videofluoroscopic swallow study performed. exclusion criteria: * any pre-existing medical diagnoses that exclude brief resolved unexplained event diagnosis including seizure disorders and cyanotic congenital heart disease * any nasal/pharyngeal/esophageal anomalies that might affect safe placement of the pharyngeal motility catheter * children fed exclusively by enteral tube * allergy to rice cereal or gelmix thickener, which will be used to adjust liquid viscosity
asthma with hypersecretion-associated gene for cystic fibrosis

Conditions: Asthma

Summary: the combination of asthma and being a carrier of genetic variants (mutations and / or polymorphisms) in the cftr gene variant would cause bronchial asthma with mucus hypersecretion. this phenotype is characterized by a more severe disease, in terms of control, quality of life, exacerbations and lung function, and a different asthma the bronchial hypersecretion without inflammatory phenotype.

primary objective: determine the presence of genetic variants (mutations and / or polymorphisms) of the cftr gene in patients with asthma with or without bronchial mucus hypersecretion. secondary objectives: to identify genetic variants (mutations and / or polymorphisms) of the most common cftr gene in the asthmatic population. -to define the inflammatory phenotype of asthma with bronchial mucus hypersecretion. -to compare the severity, control, quality of life and frequency of exacerbations of asthma patients with or without bronchial mucus hypersecretion

Eligibility criteria:
inclusion criteria: asthmatic patients aged between 18 and 80 years.they have not a respiratory infection in the last month. criteria for exclusion: presence of other lung disease, sequelae of tuberculosis, bronchiectasis (large, secondary to a different asthma respiratory disease), cystic fibrosis, residual pleural disease, interstitial diseases, severe comorbidity, patients with oral corticosteroids or other immunomodulators by causes other than asthma.

Keywords: asthma cystic fibrosis
association study to evaluate tfpi gene in cad in han chinese

Conditions: Coronary Heart Disease

Summary: the cases were hospitalized patients from two medical centers in beijing and harbin respectively. venous blood was collected by standard vein puncture in fasting condition.

in our study, the cad was defined by one of the following criteria: (1) based on world health organization criteria in terms of elevations of cardiac enzymes, electrocardiography (ecg) and clinical symptoms (angina, chest pressure, or shortness of breath); (2) angiographic evidence of more than 50% stenosis in one or more major coronary arteries; (3) previous history of pci (percutaneous coronary intervention) or cabg (coronary artery bypass graft). the controls were selected from the two medical centers meeting the following criteria: (1) with no family history for cad; (2) no clinical symptoms for cad; (3) resting ecg showed normal results. the subjects with two or more risk factors of cad (age\>45 for man and \>55 for woman, hypertension, diabetes, overweight, hyperlipidemia) were subjected to treadmill stress test and selected as controls if their ecg were normal without clinical symptoms. those with history of cardiomyopathy, valvular disease, peripheral vascular disease, stroke, severe hepatic and kidney deficiency were excluded in our study. venous blood was collected by standard vein puncture in fasting condition. four single-nucleotide polymorphisms (snps) (rs7586970, rs6434222, rs10153820 and rs8176528) were detected with polymerase chain reaction-direct sequencing method. and the genotypes of these snps were determined in both cad patients and non-cad controls.

Eligibility criteria:
inclusion criteria: the coronary artery disease was defined by one of the following criteria-(1) based on world health organization criteria in terms of elevations of cardiac enzymes, electrocardiography (ecg) and clinical symptoms (angina, chest pressure, or shortness of breath); (2) angiographic evidence of more than 50% stenosis in one or more major coronary arteries; (3) previous history of pci (percutaneous coronary intervention) or cabg (coronary artery bypass graft). the controls were selected from the two medical centers meeting the following criteria: (1) with no family history for cad; (2) no clinical symptoms for cad; (3) resting ecg showed normal results. the subjects with two or more risk factors of cad (age\>45 for man and \>55 for woman, hypertension, diabetes, overweight, hyperlipidemia) were subjected to treadmill stress test and selected as controls if their ecg were normal without clinical symptoms. exclusion criteria: * those with history of cardiomyopathy, valvular disease, peripheral vascular disease, stroke, severe hepatic and kidney deficiency were excluded in our study.

Keywords: tissue factor pathway inhibitor
prospectively predict the efficacy and explore the mechanism of treatment of gastrointestinal tumors based on peripheral multi-omics liquid biopsy

Conditions: Advanced or Late Stage Gastrointestinal Cancer

Summary: dynamic multiomics detection of plasma derived exosomes to explore the efficacy and mechanism of anti-her2, immunotherapy and anti-cldn18.2 of gastrointestinal cancer.

the investigators will recruit 500 advancer/late-stage gastrointestinal cancer patients.blood and tumor tissue will be collected at treatment baseline, every time point response till disease progression. all samples will be processed by exosomes proteome detection to explore the efficacy and mechanism of anti-her2, immunotherapy and anti-cldn18.2 of gastrointestinal cancer.

Eligibility criteria:
inclusion criteria: * • having signed informed consent * age:18-80 years old * histologically confirmed gi cancer * unresectable recurrent or metastatic gi cancer * previous neo-adjuvant or adjuvant treatment for gi cancer, if applicable, more than 6 months * measurable disease according to the recist criteria * karnofsky performance status ≥70 * life expectancy of ≥3 month * no prior radiotherapy except radiotherapy at non-target lesion of the study more than 4 weeks * alt and ast\<2.5 times uln (≤5 times uln in patients with liver metastases) * serum albumin level ≥3.0g/dl * serum akp \< 2.5 times uln * serum creatinine \<uln, and ccr \< 60ml/min * bilirubin level \< 1.5 uln * wbc\>3,000/mm3, absolute neutrophil count ≥2000/mm3, platelet\>100,000/mm3, hb\>9g/dl exclusion criteria: * previous systemic therapy for metastatic gi cancer * surgery (excluding diagnostic biopsy) within 4 weeks prior to study entry contraindications of nuclear magnetic resonance image such as fitment of cardiac pacemaker , nerve stimulator, or aneurysm clip, and metallic foreign body in eye ball and so on. * allergic constitution or allergic history to protium biologic product or any investigating agents. * severe heart disease or such history as recorded congestive heart failure, uncontrolled cardiac arrhythmia, angina pectoris needing medication, cardiac valve disease, severe abnormal ecg findings, cardiac infarction , or retractable hypertension. * pregnancy or lactation period * other previous malignancy within 5 year, except non-melanoma skin cancer * legal incapacity
vs-sense result reading clarity

Conditions: Vaginitis

Summary: this study is designed to demonstrate the result reading clarity of the vs-sense is substantially equivalent to the result reading clarity of the nitrazine ph paper test for vaginal secretions.

once informed consent has been signed, the clinician will perform the following: record baseline variables in the crf. the 1st clinician will obtain a vaginal secretion sample by using the vs-sense swab. the 1st clinician will obtain the specimen by separating the labia to expose the vagina. the yellow tip of the vs-sense swab will be inserted into the vagina approximately 5 cm/ 2". the 1st clinician will use the vs-sense according the instructions for use - attachment 1 to the protocol. the 1st clinician will read the vs-sense results and record them on the designated form (clinician report - vs-sense result form), and fill out the table regarding the vs-sense reading clarity on the same form.vaginal examination (including speculum examination) - will be performed by a 2nd clinician, masked from the results of the 1st clinician test. the 2nd clinician will use a vaginal swab for ph measurement by nitrazine ph paper test. the nitrazine ph paper test will be performed according to strict manufacturer's instruction. the 2nd clinician will read the results of the nitrazine ph paper test result, document it on the clinician report - ph test result form, and fill out the table regarding the ph test reading clarity on the same form.

Eligibility criteria:
inclusion criteria: 1. symptomatic women, ages 18 and above. 2. subjects willing and able to sign the informed consent form. exclusion criteria: 1. subjects are unable or unwilling to cooperate with study procedures. 2. subjects are currently participating in other clinical study that may directly or indirectly affect the results of this study. 3. women with blood present in their vaginal secretion. 4. subjects that have had sexual relations or applied vaginal douched within the previous 12 hours. 5. subjects that applied vaginal medications within the last 3 days. 6. subjects with symptoms and signs of pelvic inflammatory disease.

Keywords: vaginal infection, color appearance
the role of affect regulation and self-presentation in the expressive writing intervention

Conditions: Posttraumatic Stress Disorders

Summary: the purpose of the present study is twofold. first, we will attempt to examine the role that emotion regulation and self-presentation play as potential moderators in the expressive writing paradigm. we hypothesize that expressive writing participants who demonstrate greater abilities to regulate their emotions at baseline will improve more on our outcome measures. we also hypothesize that those expressive writing participants who demonstrate higher levels of self-presentation at baseline will improve less on our outcome measures. the second aim of the study has two related objectives. first, we will attempt to investigate whether the expressive writing intervention can increase and enhance an individual's emotion regulation abilities. related to this, we will then go on to examine whether emotion regulation can be looked at as a potential mechanism of action in the expressive writing procedure. related to these two objectives, we hypothesize that in comparison to the control group, participants in the expressive writing condition will show increases in their ability to regulate their emotions from baseline to four week follow up. moreover, we predict that greater gains in emotion regulation abilities for the expressive writing participants will be significantly related to greater gains in outcome measures.


Eligibility criteria:
inclusion criteria: * fluent in english * previously experienced trauma (not current or ongoing; excluding bereavement) * currently experiencing trauma-related distress exclusion criteria: * currently involved in psychotherapy * currently taking psychotropic medications * imminent threat to self or others

Keywords: expressive writing trauma intervention posttraumatic stress
comparison of two different virtual reality methods in patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: as a chronic, autoimmune, inflammatory disease of the central nervous system, multiple sclerosis (ms) is a neurologic problem which the most frequent cause of disability in young adults. fatigue, pain, spasticity, muscle weakness, depression, as well as balance and gait disorders are amongst the symptoms of ms. balance disorders and the falls caused by them are the most frequent problems which result in disability of ms patients, with 75% of all patients being affected during the course of disease. when considering previous studies carried out on physiotherapy and rehabilitation practices in the light of balance disorders and other related problems faced by ms patients, it can been that various physiotherapeutic approaches are applied with varying follow-up times and in the form of hospital sessions, home sessions, or group training. posture and balance problems in ms patients are tried to be solved through long-lasting treatment sessions using traditional methods of physiotherapy, where less patient participation is observed. fatigue, psychological impairment, and insufficient motivation are other aspects which influence the success of treatment and which need to be addressed in ms patients. in contrast to traditional methods of physiotherapy applied in form of long-lasting treatment sessions, technology-supported rehabilitation approaches have emerged in recent years. it can be seen that different systems have started to be employed in the physiotherapy of many chronic diseases, either alone or in company with traditional methods. even though the clinical use of these systems is becoming widespread, there are certain gaps in terms of the systems' impacts, comparative advantages, or cost effectiveness. keeping this in mind, the purpose of this study is to investigate and compare the impacts of 'nintendo wii fit' and 'balance trainer', as two of the technologic methods with therapeutic impact which have started to be used for different diagnosis groups in recent years, on the balance and posture parameters of ms patients, with the ultimate aim to introduce a whole new point of view to traditional physiotherapy and rehabilitation studies.


Eligibility criteria:
inclusion criteria: * . participants who were ambulatory and volunteer to participate to the study, in a stable phase of the disease, without relapses or worsening in the last 3 months, with an edss between 2.5-6 and aged between 25 to 60 years exclusion criteria: * physical activity more than 150 minutes per week, were pregnant, had blurred vision, had psychiatric problems, or severe cognitive impairment.

Keywords: multiple sclerosis rehabilitation postural balance exercise
imp3 and pcna expression in laryngeal squamous cell carcinoma in sohag governorate

Conditions: Laryngeal Squamous Cell Carcinoma

Summary: laryngeal cancer is responsible for 2-5% of all new cancer cases worldwide. squamous cell carcinoma of the larynx (lscc) is the most common malignant tumor of the larynx, accounting for 85-90% of all laryngeal malignancies. despite significant therapeutic developments in recent decades, increases in patients' 5-year survival rates are still minimal , which is likely due to late-stage diagnosis and other complex factors. therefore, to improve the outcome, timely diagnosis, selection of the most appropriate therapy, and an adequate follow-up approach is needed. the insulin-like growth factor ii m-rna-binding protein 3 (imp3) is a new biomarker that may be implicated in the carcinogenesis of various malignancies, including head and neck squamous cell carcinoma. imp3 normally expressed in embryonic tissue but decreases after birth and is no longer detectable in adult tissue with the exception of a few tissues. as a result, imp3 is expressed only in tumors and not in neighboring normal tissues. proliferating cell nuclear antigen (pcna) is a nuclear protein that acts as a cell proliferation marker. in most forms of solid malignancies, such as colorectal cancer and breast cancer, pcna is closely linked to prognosis and survival. in this study, hoping to improve diagnosis of lscc and assess prognosis better by using both imp3 and pcna biomarkers. as imp3 may have a role in cell growth and proliferation and pcna is a marker of cell proliferation; studying the association between both markers in laryngeal carcinoma is recommended.


Eligibility criteria:
inclusion criteria: 1. laryngeal resection (total or partial laryngectomy) and biopsies. 2. complete clinical data. exclusion criteria: 1. patients with recurrence of the primary tumor. 2. patients with a history of preoperative chemotherapy and/or radiotherapy.
physiological, behavioural and subjective measures of listening effort

Conditions: Hearing Loss

Summary: participants will perform two different listening tasks: (1) listening to, and repeating back, sentence lists presented in noise, and (2) listening to short radio excerpts and answering subsequent comprehension questions. at the same time participants are required to perform a manual target-tracking task on a touch screen. during this study, continuous, non-invasive physiological measurements (heart rate, skin conductance and hemoencephalography) will be made from participants. using this paradigm we will be assessing the effect of different hearing aid processing algorithms on listening effort. the study takes the form of a three factor (listening task x algorithm x signal-to-noise ratio), within-subjects design. each participant performs each listening task (about 4min long each) with each algorithm (reference, noise reduction i, noise reduction ii), at two signal-to-noise ratios (+4 decibel and 0 decibel) twice (test-retest).


Eligibility criteria:
inclusion criteria: * healthy outer ear (without previous surgical procedures) * ability to fill in a questionnaire conscientiously * informed consent as documented by signature * minimum 1 year hearing aid experience * moderate-severe (n3-n5) hearing loss or normal hearing exclusion criteria: * contraindications to the md in this study, e.g. known hypersensitivity or allergy to the investigational product * limited mobility and not in the position to attend weekly appointments * inability to produce a reliable hearing test result * massively limited dexterity * known psychological problems * known central hearing disorders
telerehabilitation in patients with fibromyalgia

Conditions: Fibromyalgia

Summary: sixty-six fms patients received the same exercise program for 8 weeks and divided, synchronous (n: 33), asynchronous (n: 33). pain (visual analog scale, vas), functional limitations and disabilities (revised fibromyalgia impact questionnaire, fea), health-related quality of life (hrqol; short form-12, sf 12), catastrophizing (pain catastrophizing scale, pcs), anxiety and depression (hospital anxiety and depression scale, had), functional capacity (6-minute walking test, 6mwt), muscle strength (arm curl test) joint position sense (laser cursor assisted angle repetition test, li-ratt) were assessed at baseline, mid-treatment (week 4), end of treatment (week 8), and eight weeks after treatment (week 16).

materials and methods: a randomized clinical study. sixty-six fms patients received the same exercise program for 8 weeks and divided, synchronous (n: 33), asynchronous (n: 33). pain (visual analog scale, vas), functional limitations and disabilities (revised fibromyalgia impact questionnaire, fea), health-related quality of life (hrqol; short form-12, sf 12), catastrophizing (pain catastrophizing scale, pcs), anxiety and depression (hospital anxiety and depression scale, had), functional capacity (6-minute walking test, 6mwt), muscle strength (arm curl test) joint position sense (laser cursor assisted angle repetition test, li-ratt) were assessed at baseline, mid-treatment (week 4), end of treatment (week 8), and eight weeks after treatment (week 16).

Eligibility criteria:
inclusion criteria: * diagnosed with fms by the physician in accordance with acr 2016 criteria, * having independent mobility, * not having advanced vision and hearing loss, * minimum literacy, participating voluntarily, making video calls, internet and smartphone access exclusion criteria: * have a rheumatic disease with more prominent symptoms than fms, * have an active infection, * have a surgical operation in the last three months, * have an uncontrollable chronic disease, * have another musculoskeletal disorder

Keywords: fibromyalgia telerehabilitation mobile health