Kornimate/medical-research-clean huggingface dataset:
evaluation of peroral endoscopic myotomy to treat zenker's diverticulum

Conditions: Zenker Diverticulum

Summary: this is a multicenter investigator-initiated trial between baylor-scotts \& white (bsw) and methodist health system (mhs). this study will be conducted via a retrospective review and a prospective patient registry. patients who have undergone the zpoem procedure performed by the physicians listed in this protocol will be included, as well as patients who will have this procedure in the future. data that will be collected at mhs will be entered into an excel spreadsheet. patient demographic information will be collected via a review of subjects' electronic medical records. available patient outcomes will be collected via a review of electronic medical records. this review will be conducted from 1/1/2017 through 12/31/2025.

this is a multicenter investigator-initiated trial between baylor-scotts \& white (bsw) and methodist health system (mhs). this study will be conducted via a retrospective review and a prospective patient registry. patients who have undergone the zpoem procedure performed by the physicians listed in this protocol will be included, as well as patients who will have this procedure in the future. data that will be collected at mhs will be entered into an excel spreadsheet. patient demographic information will be collected via a review of subjects' electronic medical records. available patient outcomes will be collected via a review of electronic medical records. this review will be conducted from 1/1/2017 through 12/31/2025. to obtain the follow-up information, potential subjects will be identified using the same process described in the previous paragraph and will be contacted by a member of the institution's research team to answer questions about their symptoms post-surgery. these are listed in the zpoem data collection sheet. these questions may be administered over the phone, via email, or by mail. subjects enrolled in the patient registry will have follow-up data collected at 2-time points: 2 weeks post-op and 3 months post-op. primary endpoints and other variables to be collected are those listed on the zpoem data collection sheet. primary subject endpoints include, but are not limited to: * dysphagia score(s) - depending on what is available in emr * weight gain following surgery

Eligibility criteria:
inclusion criteria: * patients 18 years of age or older * any patient of the physicians listed in this study who has undergone the zpoem procedure to treat zd at mhs * for prospective registry: ability to give informed consent exclusion criteria: * for prospective registry: unable or not willing to provide informed consent

Keywords: zenker's diverticulum peroral endoscopic myotomy
cytochrome p450 2e1 and iron overload

Conditions: Insulin Resistance; Iron Overload

Summary: the aim of the study is to determine, in patients presenting hepatic iron overload (genetic haemochtomatisis or dysmetabolic iron overload syndrome), the effects of venesection therapy on cytochrome p450 2e1 activity by comparing the rates of metabolization of chlorzoxazone before and after venesection.


Eligibility criteria:
inclusion criteria: * male patients aged from 18 to 70 years * hepatic iron overload measured by magnetic resonance imaging \[mri\] (\> 36 µmol/g and \< 200 µmol/l) * homozygosity for the c282y mutation of the hfe or dysmetabolic iron overload syndrome (dios) based on the presence of at least one of these following metabolic abnormalities: * overweight: bmi \> 25 kg/m2 * waist/hip circumference (cm) \> 0.90 * diabetes mellitus (fasting blood glucose level \>1.25g/l or blood glucose level after 2 hours \> 2g/l) or glucose intolerance (fasting blood glucose level between 1.10 and 1.25g/l) * total cholesterolemia \> 6.2 mmol/l or hdl-cholesterol \< 0.9 mmol/l * tg\>= 1.7 mmol * written informed consent non-inclusion criteria: * consumption of alcohol \> 50 g/day and of any cyp2e1 inhibitor substances * smoker \> 5 cigarets/day * history of blood donation or venesection * other causes of iron overload: aceruloplasminaemia, haematological disorder (abnormal blood counting), late cutaneous porphyria (cutaneous bullous disorders and photosensibilisation) , martial treatment, repeated transfusions. * inflammatory syndrome (crp \> 3ng/ml)

Keywords: insulin resistance iron overload phlebotomy hepatic iron overload
exercise to slow cardiovascular ageing progression

Conditions: Cardiac Ageing; Exercise; Cardiovascular

Summary: in ageing, deleterious alterations in cardiovascular (cv) structure and function increase risks of ageing-related cardiovascular disease (cvd). investigators found that these cv alterations were associated with circulating serum metabolites, suggesting a metabolic basis to cv ageing. investigators hypothesize that modification of these metabolites by intervention, such as exercise, may retard cv alterations and reduce cvd in ageing.

participants from each stratum will be randomized to receive either an exercise program intervention or no exercise. at the start and end of study, participants will undergo cardiovascular imaging and metabolic profiling. investigators will determine if exercise can reverse high-risk metabolic profiles and improve cardiovascular structure and function. without clear mechanisms to explain cardiovascular ageing nor interventions known to retard cardiovascular ageing, our approach will provide much needed translational evidence to incorporate targeted interventions aimed at reducing cardiovascular disease risk in older populations.

Eligibility criteria:
inclusion criteria: * age \>=21 years old * outdoor ambulant exclusion criteria: * wheelchair or bed-bound * dementia * residing in sheltered or nursing home * cancer * participation in ongoing clinical trials that involve interventional drugs or devices * aneurysms * acute infections (in the last six months) * uncontrolled thyrotoxicosis * neuromuscular, musculoskeletal or rheumatoid disorders that are exacerbated by exercise * uncontrolled asthma or chronic lung disease * restrictive lung disease
mechanism of weight loss after endoscopic and laparoscopic sleeve procedures

Conditions: Weight Loss; Reflux

Summary: the purpose of this research study is to understand the mechanism of weight loss for weight loss procedures: that is laparoscopic sleeve gastrectomy and endoscopic sleeve gastroplasty.

we want to better understand the mechanisms for weight loss by understanding the anatomic and physiologic changes that occur with gastric restrictive procedures for weight loss and to determine the differences in metabolic profile between the two restrictive procedures. we also want to identify the rate of gastro esophageal reflux disease (gerd) in patients undergoing gastric restrictive procedures for weight loss.

Eligibility criteria:
inclusion criteria: 1. bmi ≥ 30 kg/m2 scheduled to undergo a bariatric intervention 2. patients who will be undergoing esg or lsg as part of their clinical care age between 18 and 75 years. 3. both male and female subjects will be included in the study. 4. subjects from any ethnic background will be included in the study. 5. female participants of childbearing age should not be pregnant. (pregnancy test will be performed on all women of child bearing potential before any standard of care endoscopic procedure. for the purpose of the study we will record that information in the patient study records). 6. successfully complete the screening process. 7. patients able to provide written informed consent on the irb/ec-approved informed consent form. 8. demonstrate willingness to follow protocol requirements, including follow-up schedule, and completion of questionnaires. 9. having standard of care therapy (endoscopic or laproscopic) for treatment of obesity. exclusion criteria: 1. pregnant or planning to become pregnant during period of study participation. 2. female participants who are breast-feeding. 3. severe immunodeficiency. 4. severe malnutrition. 5. the participant has life expectancy of less than 1 year due to other medical conditions.
detection of postoperative respiratory depression in high risk patients utilizing minute ventilation monitoring

Conditions: Respiratory Depression

Summary: respiratory volume monitor (rvm) (exspiron) is superior to continuous pulse oximetry in detection of postoperative respiratory depression in high risk patients.

aims are to: 1) estimate the incidence of postoperative respiratory depression in high risk patients as detected by continuous pulse oximetry 2) estimate the incidence of postoperative respiratory depression in high risk patients as detected by continuous respiratory volume monitor (rvm) (exspiron) 3) assess the agreement between the continuous pulse oximetry and continuous respiratory volume monitor (rvm) (exspiron) in detection of postoperative respiratory depression in high risk patients

Eligibility criteria:
inclusion criteria: * patients who suffered rib fractures or patients who are weaned from mechanical ventilation and recently extubated. exclusion criteria: * have known contraindication/allergy to neuroaxial/paravertebral nerve block anesthesia * patients allergic to morphine. * have an asa class \> iv
evaluation of the prevalence of pulmonary hypertension in adult patients with sickle cell disease

Conditions: Sickle Cell Disease

Summary: recent data show that pulmonary hypertension (ph), defined by a tricuspid regurgitation jet (trj) velocity \> or equal at 2.5m/s on doppler echocardiography, is present in about 30% of adults with sickle cell disease (scd) and is associated with poor prognosis. however in scd the occurrence of ph (defined by mean pulmonary arterial pressure (mpap)\> or equal at 25 mmhg) is related to at least 3 mechanisms: ph due to hyperkinetic state with high cardiac output (co) but normal pulmonary vascular resistance (pvr \ 15 mmhg), or precapillary pulmonary arterial hypertension (pah) defined by mpap \> or equal at 25 mmhg, pcwp\ or equal at 160 dynes.the aim of this study is to evaluate in a french population of adults with sickle cell disease the characteristics, prevalence and prognosis of pulmonary hypertension.

consecutive adult patients with sickle cell disease (scd) had a doppler echocardiography to evaluate if they had a suspected pulmonary hypertension (ph) on the basis of a tricuspid regurgitation jet (trj) velocity \> or equal at 2.5m/s. in this case, a right heart catheterization was performed to confirm or not this diagnosis and its mechanisms. each included patient was followed every year for 3 years: during each visit, a clinical evaluation was obtained and a doppler echocardiography. in case of emergence of a suspected ph, a right heart catheterization was performed to confirm or not this diagnosis and its mechanisms. three groups of patients were defined: no ph, precapillary ph, and a third group including post-capillary ph and hyperkinetic state. these groups were well defined on the basis of the results of th doppler echocardiography and right heart catheterisation. characteristics of patients and their prognosis were evaluated in each group. in the same, way, biological study is planned to evaluate some biological markers of the mechanism of ph, and prognostic factors.

Eligibility criteria:
inclusion criteria: * homozygous ss sickle cell disease * male or female \> 18 years of age * voc (vaso-occlusive crisis) or acs (acute chest syndrome)within 6 weeks of inclusion ("stable state") * signed written informed consent exclusion criteria: * creatinine clearance \< 30 ml/mn * prothrombin ratio \< 50% * severe pneumopathy and tlc (total lung capacity) \< 70%

Keywords: doppler echocardiography pulmonary hypertension sickle cell disease
clinical test of the mrghifu system on uterine fibroids

Conditions: Uterine Fibroids

Summary: the objectives of this program are to verify the safety and effectiveness of the mrghifu system developed by the division of medical engineering of national health research institutes (nhri)

between 25 % - 50 % of women of childbearing age have uterine fibroids. also, 25% of women with fibroids suffer from the metrorrhagia, menorrhagia, dysmenorrheal or pelvic compression so that they don't have a good quality of life. the worse case is the fertility of patients with fibroids is hindered. the current clinical treatment is medication or surgery. medication can only suppress the symptom temporarily when the hysterectomy method of removing part or all of uterus can cure the patient completely. however, the hysterectomy is an invasive operation and the women with fibroids who plan to have a baby don't accept this kind of treatment. magnetic resonance-guided high-intensity focused ultrasound (mrghifu) system for the noninvasive treatment of uterine fibroids has been developed and was approved by the us food and drug administration (fda) in 2004. the ultrasound waves emitted by the ultrasonic probe propagate through the skin, fat, muscle, soft tissues and converge on fibroids at focus. high energy/intensity at focus causes the thermal necrosis of the fibroid tissue in several seconds. the whole process of hifu ablation of fibroids is monitored and guided by mr thermometery. the advantage of mr-hifu modality includes no incision, outpatient treatment and few side effects. the objectives of this program are to verify the safety and effectiveness of the mrghifu system developed by the division of medical engineering of national health research institutes (nhri), to achieve the clinical trial at the chang-gung memorial hospitals of linkou and to commercialize the self-developed mrghifu system. the mission is to conduct the first-stage clinical test for 10 women with symptomatic uterine fibroids and to make two sets of hifu system. meanwhile, the impact of quality of life and satisfaction with treatment of the patients diagnosed with symptomatic uterine fibroids will be analyzed.

Eligibility criteria:
inclusion criteria: 1. already sign in the informed consent form。 2. the woman who want to operate the hysteromyomectomy, and the volume of the fibromyoma is between 5-10 cm, will be included。 3. woman age between 35\~45 years, and do not want to be pregnant 4. abdominal circumference≦95 ㎝. 5. no pregnant. 6. mri compatible. exclusion criteria: 1. pregnant or breast-feeding. 2. mri uncompatible. 3. woman who has scar in abdomen. 4. immunodeficiency or cancer. 5. use the clinical medicine before 3 month age. 6. the woman who will not follow the project. -

Keywords: uterine fibroid magnetic resonance imaging ultrasound non-invasive therapy
effect of intravenous fentanyl on the occurrence of postoperative nausea and vomiting according to time of administration around the end of tonsillectomy with or without adenoidectomy

Conditions: Follicular Tonsillitis (Chronic)

Summary: fentanyl is a commonly used drug for the prevention of emergence agitation and reduction in postoperative pain in children receiving tonsillectomy. however, fentanyl can cause postoperative nausea and vomiting (ponv), which is a main target side effect that medical staff strives to prevent. however, recent meta-analysis showed that the incidence of ponv may be different depending on the time of administration of fentanyl. however, the research design of patients enrolled in each study, such as the age, the name of the operation, and the method of anesthesia, is not identical. the aim of this study was to evaluate the efficacy and safety of fentanyl in patients undergoing tonsillectomy with a prospective randomized controlled trial. secondary outcomes include incidence and severity of emergence agitation and anesthesia recovery time, postanesthesia care unit (pacu) time, side effects.


Eligibility criteria:
inclusion criteria: * pediatric patients aged 3 to 7 years with asa 1-ii scheduled for tonsillectomy (or adenoidal tonsillectomy) exclusion criteria: * 1. history of developmental disorder, cognitive impairment, cerebral palsy * 2. history of seizures(not simple febrile convulsions) * 3. upper respiratory infections * 4. structural airway disease predicting difficult airway * 5. history of an adverse reaction, including allergic reactions to fentanyl
impact of rutin and vitamin c combination on oxidative stress, insulin sensitivity and lipid profile in type 2 diabetic patients

Conditions: Type 2 Diabetes Mellitus

Summary: the objective of this study is to investigate the effect ofrutin and vitamin c combination in comparison with vitamin c alone on the oxidative and antioxidative status , insulin resistance and lipid profile in type 2 diabetic patients.


Eligibility criteria:
inclusion criteria: * • patients' age 35 years or older having type 2 diabetes mellitus. * patients taking oral diabetic medications (sulfonylurea) not taking insulin. * able to understand and willing to sign a written informed consent document exclusion criteria: * • pregnant and breast feeding females • use of vitamin supplements containing vitamin c or other antioxidants. * patients with renal or hepatic failure. * patients taking insulin as antidiabetic treatment

Keywords: type 2 diabetes rutin vitamin c oxidative stress insulin resistance lipid profile
paracetamol with caffeine to treat episodic tension type headache

Conditions: Headache, Tension-Type

Summary: this study will compare a fast-absorbing paracetamol plus caffeine formula with placebo and an over-the-counter dose of paracetamol and ibuprofen to treat episodic tension headache.


Eligibility criteria:
inclusion criteria: * diagnosis of episodic tension-type headache consistent with all of the following: 1. number of days with the condition is historically greater than or equal to two per month 2. onset of condition was greater than or equal to 12 months from visit 1 3. age of onset was \< 50 years 4. severity of headaches is historically at least moderate 5. duration of headaches is historically greater than or equal to four hours, if untreated 6. number of headache episodes was greater than or equal to 4 and less than or equal to 10 during each of the three months immediately prior to visit 1 7. treatment of headache episodes with otc analgesics has historically provided pain relief in less than or equal to 2 hours exclusion criteria: * subject has chronic tension type headache, which is defined as headache on more than 15 days per month for 3 months. * if a migraine sufferer,subject averages more than one episode per month, is incapable of differentiating between tension-type headaches and migraine headaches, and/or requires regular or prophylactic use of migraine medications

Keywords: caffeine paracetamol tension headache
a phase ii study of parotid-gland sparing imrt in patients with midline tumour of the head and neck

Conditions: Oropharyngeal Squamous Cell Cancer; Hypopharyngeal Squamous Cell Cancer

Summary: this study is a phase ii trial designed to test the feasibility of delivering imrt to head and neck cancer patients with tumours arising in the midline (oropharynx and hypopharynx), and to assess possible improvement in reducing the incidence of xerostomia with bilateral superficial lobe parotid sparing imrt.


Eligibility criteria:
inclusion criteria: * histologically confirmed locally advanced hnscc arising from the oropharynx or hypopharynx with high risk of bilateral parapharyngeal space involvement exclusion criteria: * patients \<18 years old or with a previous malignancy other than non-melanomatous skin cancer

Keywords: involvement of bilateral parapharyngeal spaces
impaired gustatory sensory perception in obese and obese diabetic persons

Conditions: Obesity; Diabetes

Summary: the aim of the study is to compare several parameters in three distinct groups of subjects: persons with obesity, persons with obesity and diabetes and persons with neither obesity nor diabetes: * the electrical activity in response to a sweet solution, measured before and after a standard meal, using gustatory evoked potentials (recording explained below) * blood hormone levels related to weight gain (insulin, dopamine, ghrelin, leptin: measured in blood samples) * levels of activity and quantity of an enzyme present in the saliva, amylase, which is able to break down ingested starch into several molecules of glucose. all of these parameters will be correlated to determine whether the results are different in the 3 groups of subjects in the study.


Eligibility criteria:
inclusion criteria: * patients who have provided written consent * patients over 18 years old * body mass index (bmi) \<25 kg/m² for healthy volunteers and bmi≥30 kg/m² for obese subjects * patients with type 2 diabetes for the group "obese diabetic subjects" exclusion criteria: * patients under guardianship * patients without health insurance cover * pregnant or breast-feeding women * active smokers * subjects with type 2 diabetes for the " healthy subjects " and " obese subjects ", subjects with type 1 diabetes for all groups * subjects who do not speak french * treatment that interferes with taste or acts on the central nervous system * anti-diabetic treatment with glp-1 analogues (glucagon-like peptide 1) or sglt2 (sodium-glucose cotransporter type 2) * known hypersensitivity to the foods proposed in the study, or the paste used to fix the electrodes, or to paraffin wax or to the products tested (sucrose, glucose or starch for the gustatory evoked potentials and triangular tests)
hemodynamic measurements of macrocirculatory and perfusion parameters in icu

Conditions: Septic Shock; Hemodynamic Instability; Vasoconstriction

Summary: in septic shock there is growing evidence of a state of hemodynamic "disconnection" with seemingly adequate macrocirculatory values despite actual microcirculation failing to meet cellular demand. norepinephrine (ne) is recommended as first choice vasoactive agent for the treatment of septic shock. however, the dynamic effects of ne on macro- and microcirculation and perfusion parameters has not been described in detail in the context of septic shock, precluding rational individualized titration of ne and fluids, as recommended recently. in the present prospective observational multicenter study in adult septic shock patients, we intend to explore the effects of ne on preload dependency and tissue perfusion by evaluating the correlation and potential discrepancies between macro- and microcirculation both during titration of ne and after fluid resuscitation. the conclusions drawn from our study will contribute to the physiological knowledge necessary for establishing individualized evidence-based bedside management of hemodynamics in the setting of septic shock.


Eligibility criteria:
inclusion criteria: * suspected or documented infection * need for vasopressors to maintain mean arterial blood pressure (map) ≥65 mmhg * serum lactate levels \>2 mmol/l * norepinephrine infusion of \> 0.2 mcg/kg/min exclusion criteria: * absolute contraindication for esophageal doppler or urinary catheter insertion as noted in the patients' charts. * severe valvular pathology and cardiac arrhythmias resulting in severe hemodynamic instability. * lithium treatment * treatment with other vasopressor or inotropic drugs.

Keywords: septic shock norepinephrine hemodynamic microcirculation intensive care