Kornimate/medical-research-clean huggingface dataset:
effect of respiratory versus aerobic training on respiratory and immunity efficiency in recovered covid- 19 patients

Conditions: Covid 19 Infection

Summary: this study will be conducted on eighty patients of both sexes with age ranging from 35 to 45years. the will be recovered from covid-19 infection with chest symptoms. they will be selected from nasr city police authority hospital. they will be randomly assigned into 3 equal groups.

this study will be conducted on eighty patients of both sexes with age ranging from 35 to 45years. the will be recovered from covid-19 infection with chest symptoms. they will be selected from nasr city police authority hospital. they will be randomly assigned into 3 equal groups. participants will be assigned into 3 groups equal in number (group a, group b, group c) group a (respiratory training group) : it will include 30 patients of both sexes, recovered from covid-19 infection. in addition to medical drugs, they will receive respiratory training for 6 weeks. group b : (aerobic training group) : it will include 30 patients of both sexes, recovered from covid-19 infection. in addition to medical drugs, they will receive aerobic training for 6 weeks group c : (control group) :it will include 20 patients of both sexes, recovered from covid-19 infection on medical drugs only will receive no exercise as control group.

Eligibility criteria:
inclusion criteria: * patients recovered from covid -19 infection. * patients with body mass index 25 - 35 kg/m2 * patients previously diagnosed with chest symptoms of covid- 19 infection. * patients' body temperature less than 37.5 * blood oxygen saturation ≥95% exclusion criteria: * smokers * patients with myocardial infarction * patients with diabetes. * patients with autoimmune disease. * patients with positive covid -19 infection. * patients with previous chest diseases * a heart rate of \>100 bpm * a blood pressure of \ 140/90 mmhg * a blood oxygen saturation of ≤95% * other diseases that are not suitable for exercise (osteoarthritis knee - stroke patients, etc)
acute responses of postural alignment, kinematic synergy, and intermuscular coherence to postural muscle facilitation

Conditions: Posture; Musculoskeletal Equilibrium; Electromyography; Kinematics

Summary: clinicians frequently assess and intervene on postural alignment. however, research demonstrating the effects of exercise interventions in moving postural alignment toward an evidence-based standard is lacking. part of the difficulty in establishing such evidence has been a lack of theory-motivated conceptions of what "good" posture is. in other words, the prevailing understanding of postural alignment is based on the negation of what has been observed to associate with bad outcomes. this study will build upon preliminary findings from our laboratory that define good postural alignment on theoretical grounds. the investigators will measure motion capture and muscle activation patterns during simple postural alignment tasks before and after 1) a corrective exercise intervention, or 2) a control intervention based designed to inhibit superficial muscle tension. the corrective exercise intervention is designed to counteract the natural patterns in which the human skeleton tends to collapse from a standing position under the influence of gravity. the control intervention consists of passive, partner-assisted stretching. regardless of initial assignment, all participants will crossover (i.e. switch interventions) and repeat the study procedures after a 1-week washout period. behavioral indicators of movement and nervous system coordination will be used to quantify alignment before and after exercise, as well as the consistency of those alignment patterns with theoretically-defined standards. the knowledge gained from this study will contribute to evidence-based definitions of healthy postural alignment and help identify effective interventions by which clinicians can promote good posture.


Eligibility criteria:
inclusion criteria: * healthy adult * 18 - 40 years of age exclusion criteria: * recent (\< 6 months) history of lower extremity injury * recent (\< 6 months) history of other musculoskeletal or neurological disorder affecting balance * contraindications to participation in physical activity

Keywords: alignment posture motor control intervention
a prospective, multi-center, observational study of the use of permacol™ collagen paste to treat anorectal fistulas

Conditions: Anorectal Fistulas

Summary: this will be a prospective, multi-center, post-market, single arm observational study to collect clinical outcome data on the use of permacol™ collagen paste in the treatment of anorectal fistulas. the subjects will have baseline and day of surgery visits performed, and then subjects will return to the investigator for evaluation of defect and safety related morbidities at follow up visits scheduled at 1 month, 3 months, 6 months and 12 months post-surgery.

the study will enroll 100 subjects at up to 10 centers throughout the european union. the expected duration of the enrollment period is approximately 9 months. the duration of each subject's participation in the study will be approximately one year. however, at sites where the routine follow-up period is greater than one year, subjects may be followed for up to 36 months at their surgeon's discretion if they agree to it.

Eligibility criteria:
key inclusion criteria: 1. male or female subjects age 18 or older 2. subjects diagnosed with a solitary tract anorectal fistula of cryptoglandular origin key exclusion criteria: 1. history or suspicion of inflammatory bowel disease (i.e.crohn's disease, ulcerative colitis) 2. subjects with secondary tracts, horseshoe fistulas, ano/recto-vaginal fistulas, or rectourethral fistulas 3. indication of an actively infected fistula/abscess (acute sepsis)

Keywords: anorectal fistulas
the effects of yoga on body image in college women

Conditions: Body Image; Eating Disorder; Obesity; Yoga

Summary: the purpose of this study is to assess the effects of a regular yoga practice on body image in college women.

a randomized controlled design will be used to study the effects of a regular yoga practice on body image in young adult women. fifty female freshman, sophomores, and juniors between the ages of 18 and 26 years will be recruited from the university of delaware student population, specifically targeting those new to yoga. age, academic standing, availability and prior yoga experience will be evaluated. consented individuals will be randomized to one of two conditions: (1) yoga (offered 3 times per week) for 10 weeks; or (2) a control group. baseline assessments, midpoint assessments, and end-of-study assessments will be conducted on all participants. participants will be compensated for their attendance at assessment visits.

Eligibility criteria:
inclusion criteria: * freshman, sophomore, or junior at the university of delaware * available spring 2017 on mondays, wednesdays, and fridays from 1:25-2:15pm * physically able to participate in yoga exclusion criteria: * females who are seniors at the university of delaware (this is because participants in the control condition will be given a pass to participate in group fitness at the end of the study, and would not be able to use this incentive if they are seniors)
efficacy of a physiotherapy treatment in women suffering from provoked vestibulodynia

Conditions: Vestibulodynia

Summary: chronic gynaecological pain is a major medical problem that affects 20-30% of women at different moments of their life. this largely neglected issue has a significant impact on the sexual and conjugal life of women suffering from it as well as on their psychological health. furthermore, this kind of pain is not well understood, often misdiagnosed or even totally ignored. also, treatment is limited and not extensively studied. this study aims at better understanding and treating gynaecological pain. the focus of the study will be provoked vestibulodynia, pain at the entry of the vagina. the efficacy of specialized pelvic floor physiotherapy will be compared to a topical cream (lidocaine) applied to the vulva. the treatment efficacy will be assessed in 234 women (aged from 18-45 years old) suffering from provoked vestibulodynia recruited in 4 hospitals (chus, jewish general hospital, royal-victoria hospital, chum st-luc).

this is a randomised controlled trial comparing the impact of multimodal physiotherapy treatments to topical lidocaine in women suffering from provoked vestibulodyina. the first treatment consists of 10 sixty minutes weekly physiotherapy treatments including relaxation techniques, stretching and pelvic floor muscle control exercises. the second treatment is a night time application of lidocaine to the vulva for 10 weeks. physiotherapists will then evaluate women's pain and sexual function right after the treatment and 6 months later.

Eligibility criteria:
inclusion criteria: * moderate to severe pain in at least 90% of sexual intercourses. * moderate to severe pain during the cotton-swab test at one of more vestibule regions (5/10 minimum pain evaluation on the verbal pain intensity scale). * pain limited to the vestibule during vaginal penetrations and during activities applying pressure on the vestibule. * provoked vestibulodynia lasting at least 6 months prior to the study and diagnosed by a standardised gynaecologic exam protocol by one of our collaborator. exclusion criteria: * major psychiatric condition or pelvic pathology associated with a genital pain problem (e.g.: dyspareunia). * use of medication that could influence pain perception. * actual or past pregnancy. * vulvar or vaginal surgery * post-menopausal state * unwillingness to restrain from other treatments till the 6 months post-treatment evaluation. * urogynaecologic symptoms (urinary/anal incontinence, pelvic organs prolapsus, urinary/vaginal infection active or during the last 3 months). * incapacity to have sexual intercourse including vaginal penetration during the last 6 months. * physiotherapy treatments or lidocaine application prior to the study

Keywords: provoked vestibulodynia multimodal physiotherapy lidocaine
efficiency of different modes of universal adhesive

Conditions: Dental Caries; Adhesion

Summary: the purpose of this study is to evaluate and compare the clinical performance of a universal adhesive's different application modes.

class 2 composite restorations will be placed using a bulk-fill composite resin restorative on two posterior teeth with proximal caries, in a split mouth design. 25 patients will be included in the study. the teeth will be randomized into two groups according to the application mode of universal adhesive material. group 1: the universal adhesive will be used in etch-and-rinse mode group 2: the universal adhesive will be used in self-etch mode. the us public health service criteria (secondary caries, anatomical form, surface roughness, marginal integrity, marginal discoloration and retention) will be used for clinical evaluation of atraumatic resin restorations. the restorations will be evaluated at baseline and 6th, 12th, 18th, 24th months. intra-oral photos will be taken directly after treatment and at control appointments to evaluate discoloration and seconder caries under magnification. the data will be analysed statistically using fisher's exact test; and the kaplan-meier and wilcoxon method will be used to estimate survival percentages.

Eligibility criteria:
inclusion criteria: * a need for at least two but not more than four posterior tooth-colored restorations * the presence of teeth to be restored in occlusion * teeth that were symptomless and vital * a normal periodontal status * a good likelihood of recall availability. exclusion criteria: * partly erupted teeth * absence of adjacent and antagonist teeth * poor periodontal status * adverse medical history * potential behavioral problems
bilateral two levels serratus anterior plane block in pediatric cardiac surgery with median sternotomy

Conditions: Congenital Heart Disease

Summary: the serratus anterior plane block (sapb) is an anterolateral thoracic wall block that was described in 2013 by blanco et al. who presented it as an alternative to other regional anesthetic techniques. it has been described in adults as an adjunct to general anesthesia or as a primary anesthetic technique for breast surgery, it has not been widely utilized as a primary anesthetic technique in the pediatric population. it was designed to block primarily the thoracic intercostal nerves and to provide complete analgesia of the lateral part of the thorax. it provides a viable alternative to paravertebral blockade and central neuraxial block in this patient population the investigators believe that the bilateral two-level injection technique may provide effective analgesia as its efficacy was not properly investigated in corrective heart surgeries with median sternotomy in the pediatric population.


Eligibility criteria:
inclusion criteria: * risk adjustment for congenital heart surgery (rachs) category 1,2 and 3 pediatric patients undergoing corrective congenital cardiac surgeries via a median sternotomy exclusion criteria: * • refusal of legal guardian. * patient with congestive heart failure . * patient weaned from cardiopulmonary bypass on high doses of inotropic support (adrenaline or noradrenaline more than 200ng/kg/min). * patient undergoing redo cardiac surgery. * known allergy to local anesthetics. * infection at injection site. * bleeding disorders (drug induced i.e., coumadin; or genetic i.e. hemophilia; or acquired i.e. dic), coagulopathy: ptt \> 40 seconds, inr \> 1.4, platelet count \< 100x10⁹. * severe renal or hepatic insufficiency. * neurological disorders because it will be difficult to assess their pain score (e.g. cerebral palsy).
memantine in patients with chronic glaucoma

Conditions: Open-Angle Glaucoma

Summary: randomized double-masked clinical trial of memantine in patients with glaucoma


Eligibility criteria:
inclusion criteria: * glaucoma damage on examination of visual field and optic disc * good visual acuity (with glasses if needed)
adjuvant protontherapy of cervical and endometrial carcinomas

Conditions: Uterine Cervical Neoplasms; Endometrial Neoplasms Malignant

Summary: the aprove study is a prospective single-center single-arm phase-ii study. patients with cervical or endometrial cancer after surgical resection who have an indication for postoperative pelvic radiotherapy will be treated with proton therapy instead of the commonly used photon radiation. a total of 25 patients will be included in this trial. patients will receive a dose of 45-50.4 gray in 1.8 gray fractions 5-6 times per week using active raster-scanning pencil beam proton radiation. platinum-based chemotherapy can be administered if indicated. the primary endpoint of the study is the evaluation of safety and treatment tolerability of pelvic radiation using protons defined as the lack of any ctc ae grade 3 or 4 toxicity. secondary endpoints are clinical symptoms and toxicity, quality of life and progression-free survival. the aim is to explore the potential of proton therapy as a new method for adjuvant pelvic radiotherapy to decrease the dose to the bowel, rectum and bladder thus reducing acute and chronic toxicity and improving quality of life.


Eligibility criteria:
inclusion criteria: * histologically confirmed cervical or endometrial cancer * indication for postoperative radiotherapy * karnofsky index ≥ 70 * age between 18 and 80 years * written informed consent exclusion criteria: * patient refusal or patient incapable of consent * implanted active medical devices with no approval for ion beam radiation * metallic implantations in the radiation field like hip prothesis * prior pelvic irradiation * participation in another clinical trial which might influence the results of the aprove trial

Keywords: cervical cancer endometrial cancer proton therapy
chia seeds consumption in hypertriglyceridemia

Conditions: Hypertriglyceridemia

Summary: lifestyle changes including diet therapy and weight loss can improve hypertriglyceridemia (htg) . furthermore, increasing omega-3 fatty acids intake has therapeutic effects on htg. alpha-linolenic acid is the precursor of long-chain omega-3 fatty acid and it is abundant in sources such as chia seeds and flax seeds. considering the high fiber and omega-3 content of chia seeds and the existing mechanisms for improving lipid profile through fiber and omega-3, animal studies have shown the positive role of chia seed consumption on lipid profile, glycemic and lipid factors, and inflammation. however, in human studies, conflicting results have been obtained and some studies have shown beneficial effects on blood lipid, glycemic, and inflammatory factors, but in some studies, no effect has been observed. the objective of this study is to determine the effects of chia seed consumption on lipids, glycemic and inflammatory factors in people with htg.

this study is an unblinded randomized controlled clinical trial. the study will be conducted on people with mild to moderate hypertriglyceridemia whose fasting blood triglyceride levels were between 150-499 mg/dl in the previous two tests. participants who meet the following criteria will not be included in the study: being treated with fibrate medications, end-stage kidney disease, acquired immunodeficiency syndrome patients, cancer patients undergoing chemotherapy or radiotherapy, patients with liver cirrhosis, being treated glucocorticoids, continuous use of omega-3 supplements or in the past month, and pregnancy or lactation. patients will be randomly assigned to one of three study groups. the duration of the study will be 8 week. the groups are: the control group, which is given a placebo pearls containing sunflower oil. the omega-3 oil group will be given omega-3 pearls, and the chia seed group that will consume chia seeds. in addition, the participants of all three groups are subjected to a low-calorie diet. at the beginning and end of the study, the measurements include body weight, blood pressure, blood concentration of lipids, lipoproteins and inflammatory factors.

Eligibility criteria:
inclusion criteria: * - individuals who had fasting triglyceride concentration 150-499 mg/dl in their two previous tests exclusion criteria: * being treated with fibrate medications * being treated glucocorticoids * being treated with anticoagulants (except aspirin) * continuous use of omega-3 supplements or in the past month * end-stage kidney disease * acquired immunodeficiency syndrome patients * cancer patients undergoing chemotherapy or radiotherapy * patients with liver cirrhosis * pregnancy or lactation.
caprelsa® registry: a belgian registry to evaluate the use of vandetanib (caprelsa®) in current clinical practice

Conditions: Metastatic Medullary Thyroid Cancer

Summary: in this registry it is planned to include all belgian patients diagnosed with aggressive and symptomatic unresectable locally advanced or metastatic medullary thyroid cancer (mtc) who have been prescribed caprelsa® (vandetanib). the characteristics of patients receiving caprelsa® (vandetanib) will be described. therefore real life data regarding demographic characteristics, evolution of the disease, ret mutation status, the treatment before, during and after vandetanib, dose and duration of treatment with caprelsa® (vandetanib) and time of progression or death (if applicable) will be included.


Eligibility criteria:
inclusion criteria the subject population that will be observed in this registry, must fulfil all of the following criteria: 1. provision of subject informed consent 2. patients diagnosed with aggressive and symptomatic unresectable locally advanced or metastatic mtc 3. patients who already received a prescription for vandetanib in accordance with the scientific leaflet and fulfilling the reimbursement criteria of vandetanib and who are currently treated or have been treated with vandetanib 100 mg or 300 mg tablets. the prescription of the medicinal product is clearly separated from the decision to include the subject in the registry. exclusion criteria not applicable since patients participating in another study can take part in this registry.

Keywords: medullary thyroid cancer (mtc) vandetanib caprelsa
neumodx predicting study evaluation plan

Conditions: Chlamydia Trachomatis Infection; Neisseria Gonorrheae Infection

Summary: this investigational study will be conducted to evaluate the performance of the neumodx™ ct/ng assay on the neumodx™ 288 molecular system and neumodx™ 96 molecular system (collectively referred to as neumodx™ ct/ng assay test system).

clinical performance characteristics of the neumodx ct/ng assay on neumodx™ 288 molecular system and neumodx™ 96 molecular system will be evaluated in a multi-center, prospective, sampling study by comparing the diagnoses made by the neumodx™ ct/ng assay to patient infected status (pis) as the reference standard. prospectively collected urine and swab specimens from individual subjects will be tested using the neumodx™ ct/ng assay at one of the three neumodx testing sites. subjects' pis for ct and pis for ng will be determined by a central laboratory using fda-cleared, legally marketed ct/ng combo assays on pre-specified sample matrices according to the pis determination algorithms.

Eligibility criteria:
inclusion criteria: 1. male and female subjects of at least 14 years of age or older. 2. subject must be able and willing to provide informed consent. the use of a 'surrogate' or 'legally authorized representative' is allowed and shall follow the site's standard procedures, under which the clinical investigation will be conducted. 3. subjects undergoing a routine pelvic examination, subjects eligible for screening evaluations for possible stds and/or subjects known to be partners with a person with a confirmed or suspected std. 4. subject is willing to provide all required specimens. exclusion criteria: 1. female subject reports that she had a hysterectomy. 2. subject self-reports use of antibiotics within 28 days of study enrollment.
b vitamin deficiency and pregnancy complications

Conditions: Gestational Hypertension; Preeclampsia

Summary: this case-control study aims to investigate the association between b vitamins and gestational hypertension or preeclampsia.

in clinical practice, women diagnosed with gestational hypertension or preeclampsia will be asked to participate this study to fill a questionnaire reporting their basic information. meanwhile, women with matched age and gestation week and without any kinds of hypertensive disorders will also be invited for this study. participants' blood samples will be analyzed for b vitamin levels at the end of the study.

Eligibility criteria:
inclusion criteria: * pregnant women aged 18-40 years old exclusion criteria: * women with hepatitis b, syphilis, hiv/aids and other infectious diseases. * women with severe physical or mental diseases

Keywords: b vitamins pregnancy complications