Kornimate/medical-research-clean huggingface dataset:
therapist guided, parent-led, cognitive behavioural therapy (cbt) for preadolescent children with obsessive compulsive disorder (ocd)

Conditions: OCD

Summary: this preliminary study aims to examine the outcomes from a therapist guided, parent-led, cbt treatment for preadolescent children (aged 5 to 12 years old) with ocd. specifically, this study aims to: 1. examine outcomes for children who receive the therapist guided, parent-led, cbt treatment for preadolescent children with ocd. 2. examine parents' experiences and views about the acceptability of the treatment approach.

this study adapted an existing therapist guided, parent-led cbt intervention for children with anxiety difficulties, to ensure suitability for preadolescent children with ocd. this preliminary study aims to examine the outcomes from a therapist guided, parent-led, cbt treatment for preadolescent children (aged 5 to 12 years old) with ocd. specifically, this study aims to: 1. examine outcomes for children who receive the therapist guided, parent-led, cbt treatment for preadolescent children with ocd. 2. examine parents' experiences and views about the acceptability of the treatment approach.

Eligibility criteria:
inclusion criteria: children inclusion criteria: 1. aged 5 to 12 years old (when parents/carers complete the baseline questionnaires). 2. diagnosis of ocd (identified from the adis-p). 3. uk-resident. parents inclusion criteria: 1. parent/legal guardian of the child. 2. uk resident. exclusion criteria: children exclusion criteria: 1. comorbid condition, which is likely to interfere with treatment delivery, for example: 1. established autism spectrum condition (asc). 2. suspected asc (indicated by exceeding the threshold of 15 on the social communication questionnaire and where a diagnosis of asc has not been ruled out by a medical professional). 3. profound learning difficulty (evidenced by attending a specialist school). 2. risk and/or safeguarding concerns, which are paramount and would interfere with treatment delivery, for example: 1. suicidal intent. 2. recurrent or potentially life limiting self-harm. 3. significant safeguarding concerns (i.e., if the child has a child protection plan and/or is on the child protection register, and/or the research team consider the child to be suffering, or likely to suffer, significant harm). 3. if children have been prescribed psychotropic medication, the dosage must have been stable for two months. 4. children who are currently receiving other psychological support/interventions delivered by a mental health professional. parents exclusion criteria: 1. significant intellectual impairment that is likely to interfere with treatment delivery. 2. unable to access or understand written english language materials needed for the intervention.

Keywords: ocd cbt parent
efficacy of continuous apomorphine infusion on cognitive and neuropsychological functions in parkinson's disease

Conditions: Parkinsons's Disease

Summary: in parkinson's disease, treatment mainly aims to improve motor functions. however, other dysfunctions are often observed in parkinson's patients, and may have important consequences on the quality of life of patients. cognitive and neuropsychological troubles may be observed, as memory impairment or anxiety for example. as this kind of troubles is worrying for the patient himself (herself) and his/her family, treatment needs to take into account those troubles in addition to motor difficulties. in our centre, we have already used continuous apomorphine infusions among parkinson's patients and it seems to have good results. the present study aims to objectively assess the efficacy of continuous apomorphine infusions on cognitive and neuropsychological functions in parkinson's disease using clinical and positron emission tomography (pet)-scan measures.


Eligibility criteria:
inclusion criteria: * age 18 and more * parkinson's disease according to ukpdsbb diagnosis criteria * motor difficulties in spite of dopaminergic per os treatment * not eligible for deep brain stimulation for one or more reasons (age\>70, axial troubles in spite of dopaminergic per os treatment, cognitive troubles and/or hallucinations) exclusion criteria: * mattis scale \< 120 * contraindication to apomorphine (liver insufficiency, severe cognitive troubles, allergy, pregnancy, neuroleptic treatment) * contraindication to fluoro-deoxy-glucose which is used in pet-scan (allergy, kidney failure, pregnancy, breast feeding)

Keywords: not eligible for deep brain stimulation parkinsons's patients
effectiveness and safety study of lap-band treatment for obese adolescents

Conditions: Morbid Obesity

Summary: the purpose of this study is to determine whether the lap-band system is safe and effective in morbidly obese adolescents.

the primary objective of this study was to evaluate the safety and effectiveness of the lap-band system in a morbidly obese adolescent population, ages 14 to 17 years. the secondary objectives were to assess associated changes from baseline in obesity-related comorbidities as well as psychosocial functioning.

Eligibility criteria:
inclusion criteria: * between the ages of 14 and 17 at the time of enrollment * have a bmi ≥ 40 kg/m2 (with or without obesity-related co-morbid conditions) or bmi ≥ 35 kg/m2 with one or more severe co-morbid conditions * have a history of obesity for at least 2 years and have failed more conservative weight-reduction alternatives, such as supervised diet, exercise and behavior modification programs exclusion criteria: * family or subject history of congenital or acquired anomalies of the gastrointestinal tract * severe cardiopulmonary or other serious or uncontrolled organic disease * severe coagulopathy; hepatic insufficiency or cirrhosis * history of bariatric, gastric, or esophageal surgery * history of intestinal obstruction or adhesive peritonitis * history of esophageal dysmotility disorders * type i diabetes
pilot study to characterize the microbiome in cutaneous t cell lymphoma skin lesions before and after use of cln® skin care body wash

Conditions: Cutaneous T Cell Lymphoma

Summary: in this pilot study of patients with mycosis fungoides, the most common form of ctcl, we propose to primarily evaluate the impact of daily use of the cln body wash (dilute sodium hypochlorite (0.006% naocl)) on the microbiota of ctcl lesions. should dilute sodium hypochlorite body wash improve the microbiome of mf, reducing the abundance of s. aureus, future, larger studies can more fully evaluate the impact on pruritus, erythema, scaling, disease evolution and its role in ctcl management.


Eligibility criteria:
inclusion criteria: * adults ages 18-89 years of age with active mycosis fungoides. * patients with concurrent and prior malignancies are allowed as long as any concurrent malignancy does not directly involve the same skin site. exclusion criteria: * patients currently or recently (within past 4 weeks) on topical or systemic antibiotics, pregnant persons, or persons with potential of becoming pregnant or are/will be breastfeeding * patients that have initiated a new skin-directed therapy over the past month.
novel point-of-care diagnostic test for sars-cov-2 (covid-19)

Conditions: COVID-19 Infection

Summary: this study investigates a new diagnostic test in detecting sars-cov-2, the virus that causes the disease covid-19. this may help to improve testing for covid-19.

primary objective: i. to evaluate the clinical performance of a novel point-of-care diagnostic test for detecting severe acute respiratory syndrome coronavirus 2 (sars-cov-2), the virus that causes the disease called coronavirus disease 19 (covid-19). secondary objectives: i. to compare the clinical performance of provider-collected nasopharyngeal samples with self-collected nasal swab, cheek swab, and saliva sample using the novel sars-cov-2 diagnostic test. ii. to measure viral load and evaluate the role of viral load in covid-19 severity. outline: participants undergo collection of nasopharyngeal (back of the nose) samples by a medical provider and self-collection of oral, saliva, and nasal samples. after completion of study, participants are followed up at 1 month.

Eligibility criteria:
inclusion criteria: * qualifies for sars-cov-2 testing at md anderson, lyndon b. johnson (lbj) hospital, or affiliated sites (may include md anderson and lbj patients and employees) according to institutional criteria at time of enrollment * willing and able to provide informed consent * ability to perform protocol-required activities * able to speak and read english or spanish exclusion criteria: * patient or provider decision not to perform sars-cov-2 testing
combined effects of aerobic exercise and cognitive training on cognition after stroke

Conditions: Stroke

Summary: the objective of the 'exploring potential synergistic effects of aerobic exercise and cognitive training on cognition after stroke' pilot trial is to investigate the combined effects of aerobic and cognitive training on cognition after stroke. this is to lay the groundwork for a larger rct on the same topic. twenty patients greater than 6 months post-stroke will be randomly assigned into one of four following treatment groups: (i) aerobic training (aerobic group), (ii) cognitive training (cognitive group), (iii) aerobic exercise plus cognitive training (aerobic+cognitive group); and (iv) non-aerobic range of motion (rom) and unstructured mental activity (control group) (for group descriptions, please see detailed description below). we hypothesize that the combination of aerobic exercise and cognitive training will be more effective in improving cognition after stroke than either treatment on its own.

aerobic exercise: body weight support (bws) treadmill exercise at moderately high intensity (60-70% of heart rate reserve) using 15-30% bws. an additional 6-10 min will be needed for warm-up and cool-down. heart rate will be continuously monitored, and blood pressure and rating of perceived exertion (rpe) will be measured periodically. cognitive training: computerized dual n-back training program that involves a working memory task, the difficulty of which adapts to the individual participant's performance. rom exercise: non-aerobic passive and active movement of upper and lower extremity joints performed with the subject lying on a plinth. rpe will be recorded every 5 minutes to ensure intensity remains low. mental activities: unstructured mental activity: such as listening to light novels on tape, which will be selected by the subject from a pre-determined list.

Eligibility criteria:
inclusion criteria: * ≥18 years of age * diagnosis of ischemic or hemorrhagic stroke \>6months ago * be able to perform a two-step command * be able to walk ≥10m with/without aid * live within a 75km radius of the qe ii * pass a cardiology screen for safe participants in exercise training exclusion criteria: * have moderate or severe receptive aphasia * have terminal illness, life-threatening co-morbidity or concomitant neurological or psychiatric illness
massage therapy in treating patients with cancer pain

Conditions: Pain; Unspecified Adult Solid Tumor, Protocol Specific

Summary: rationale: massage therapy may help lessen pain caused by cancer. purpose: this randomized phase ii trial is studying how well massage therapy works in treating patients with cancer pain.

objectives: * determine whether the effects of massage therapy in patients with cancer pain are sufficiently promising to warrant a definitive trial. * determine the feasibility of a definitive trial. outline: this is a randomized, controlled, pilot study. patients are stratified according to in-patient status (yes vs no) and first baseline pain score ≥ 7 (yes vs no). patients are randomized to 1 of 3 treatment arms. * arm i (massage therapy): patients receive a light touch ("reiki") massage over 45 minutes. * arm ii (volunteer visit control): patients receive a 45-minute visit from a trained volunteer who will be available to sit quietly or talk with the patient to discuss issues of concern, as desired by the patient. volunteers will not touch the patient except to pat their shoulder or briefly hold their hand. * arm iii (quiet time control): patients receive 45 minutes of quiet time. pain and mood are assessed at baseline, immediately after treatment, at 6 hours and 24 hours after treatment, and then daily for the next 5 days after treatment. projected accrual: a total of 60 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: * diagnosis of cancer * baseline pain score ≥ 2 on a 0-10 rating scale where 0 = no pain * pain syndrome must be the result of cancer and/or cancer treatment * no postoperative or other acute procedural pain patient characteristics: * not specified prior concurrent therapy: * concurrent pharmacologic pain therapy allowed

Keywords: unspecified adult solid tumor, protocol specific pain
early administration of botox® in neuropathic pain due to thoracoscopy or thoracotomy

Conditions: Pain Due to Certain Specified Procedures; Neuropathic Pain

Summary: botulinum toxin type a has been reported to inhibit the release of various pain neurotransmitters (sp, cgrp, glutamate) responsible for neurogenic inflammation, a process that results from the sensitization of c-fiber nociceptors (peripheral sensitization). this action is probably responsible for the analgesic effect of botulinum toxin type a recently demonstrated in patients with neuropathic pain of peripheral origin.in those studies, patients had been suffering for years. the investigators can hypothesizes that earlier administration of botox in the course of neuropathic pain might prevent central sensitization, that is secondary to peripheral sensitization. the investigators can hope to increase efficacy of botulinum toxin type a injections and to prevent chronification of pain.


Eligibility criteria:
inclusion criteria: * daily pain, for 3 months, secondary to thoracoscopy or thoracotomy, of neuropathic origin (dn4 questionary) exclusion criteria: * contraindications for botulinum toxin

Keywords: neuropathic pain due to thoracotomy neuropathic pain due to thoracoscopy
dexmedetomidine versus morphine during cooling therapy in neonates

Conditions: Hypoxic Ischemic Brain Injury; Neonatal Encephalopathy; Perinatal Anoxic-ischemic Brain Injury

Summary: about \~3/ 1000 live-born newborns may suffer from brain injury due to a transient drop in oxygen supply to the brain during the birth process. the degree of brain injury that ensues in the first 72 hours after the injury is directly proportional to the severity of long-term childhood disabilities (e.g., cerebral palsy and developmental delays). whole-body cooling during the first 3 days of life is proven effective in reducing the severity of brain injury. however, cooling therapy leads to pain, shivering, stress, and discomfort. the best way to alleviate the pain and agitation of cooled newborns is unknown. standard practice is to provide morphine infusion to reduce pain. recently, a new drug called "dexmedetomidine" has been tested in small studies and has been found to be safe during cooling in newborns. dexmedetomidine has added beneficial effects such as anti-inflammation, faster recovery, and shorter hospital stays. this study is going to test the feasibility of conducting a future clinical trial to compare the effects of using dexmedetomidine versus morphine in the management of cooling-related pain/agitation on the severity of brain injury in the first week of life. the study will also examine the effect of dexmedetomidine compared to morphine on short-term clinical outcomes, parental experiences and developmental outcomes at 1 year.


Eligibility criteria:
inclusion criteria: 1. gestational age \>= 35 weeks 2. birth weight \>= 2500g 3. sign of perinatal hypoxic event (any of the following): (a) arterial cord blood gas or postnatal gas within 1 hour of life ph \ = 16 (b) arterial cord blood gas postnatal gas within 1 hour of life ph 7.00 -7.15 and acute sentinel intrapartum event 4. sign of neonatal encephalopathy 5. initiation of therapeutic hypothermia within 8 hours of life exclusion criteria: 1. informed consent not obtained within 20 hours of life 2. congenital brain malformations (antenatally known) 3. major chromosomal anomaly (antenatally diagnosed) 4. congenital neuromuscular disorder

Keywords: sedation analgesia dexmedetomidine morphine
efficacy of dorsal kinesio tape application for carpal tunnel syndrome in esports gamers: a randomized clinical trial

Conditions: Carpal Tunnel; Carpal Tunnel Syndrome (CTS)

Summary: this clinical trial investigates the effectiveness of kinesio tape (kt) in alleviating carpal tunnel-like symptoms and enhancing gaming performance among young adult pc gamers. the study aims to address two primary questions: does kinesio tape reduce wrist pain in adult pc gamers experiencing carpal tunnel-like symptoms? does kinesio tape improve gaming performance in this population? researchers will compare the effects of kt applied to the wrist versus the scapular spine to determine if wrist application provides greater pain relief and performance benefits. participants will undergo: screening \& consent (up to 30 minutes via zoom): informed consent and a phalen's test to assess carpal tunnel-like symptoms. baseline (day 0, 75 minutes): completion of a demographic survey, 15 minutes of gaming on kovaaks fps aim trainer, kt application, 15 minutes of post-application gaming, and surveys (boston carpal tunnel syndrome severity \[bcss\] and kt feedback). days 1 \& 2 (15 minutes each): kt removal and reapplication, followed by bcss and kt feedback surveys. day 3 (75 minutes): repeat gaming tests, kt application, and completion of bcss and kt feedback surveys, mirroring day 0 procedures. total time commitment: approximately 210 minutes (3.5 hours) over four sessions.


Eligibility criteria:
* over 18 years of age * test positive for phalen's screening * experience any carpal tunnel-like symptoms * self identified pc gamer

Keywords: carpal tunnel carpal tunnel syndrome gamers pc gamers esports first person shooter kinesiotape
study on prenatal diagnosis and closed-loop management system of congenital talipes equinovarus

Conditions: Prenatal Diagnosis and Closed-loop Management System of Congenital Talipes Equinovarus

Summary: the study intends to establish a closed-loop management from prenatal to postnatal through prospective cohort, and comprehensively utilize ultrasound and mri technology to establish a prenatal diagnosis and evaluation system for congenital talipes equinovarus. on the basis of existing genetic testing, further use of whole-exome sequencing and other genomic methods to explore possible pathogenic genes and loci, and clarify the pathogenic mechanism of congenital talipes equinovarus. therefore, congenital talipes equinovarus can improve its diagnosis and treatment capacity, reduce the disability rate related to congenital talipes equinovarus, and prevent it well.


Eligibility criteria:
inclusion criteria: 1）single pregnant women 2) "congenital talipes equinovarus" suggested by ultrasound exclusion criteria: twin or multiple pregnancies
effect of intravenous patient-controlled analgesia (iv-pca) with fentanyl in adults for acute postoperative pain control

Conditions: Nausea; Vomiting

Summary: in this retrospective study, the investigators examined incidence and risk factors of postoperative nausea and vomiting (ponv) in patients with fentanyl-based intravenous patient-controlled analgesia (iv-pca).


Eligibility criteria:
inclusion criteria: 1. adults between 20 to 60 years old 2. date from 1st, may 2011 to 31st, october 2011 3. patients with fentanyl based intravenous patient-controlled analgesia for postoperative pain control exclusion criteria: 1. reoperation within 48 hours 2. patients who cannot express numerical rating scale for pain due to sedation

Keywords: intravenous patient-controlled analgesia iv pca
first-line intervention for ptsd - intensive treatment

Conditions: PTSD - Post Traumatic Stress Disorder

Summary: the goal of this clinical trial is to learn if an intensive program can treat post-traumatic stress disorder (ptsd) in adults getting treatment for the first time, and whether it has lower societal costs. the main questions it aims to answer are: * does an intensive program reduce ptsd symptoms? * how expensive is it on a societal level? researchers will compare the intensive program to the standard weekly treatment to see if the intensive program works to treat ptsd. participants will: * get 5 days of intensive treatment in two weeks (with two preparatory and closing sessions), or weekly sessions * get questionnaires and interviews 5 times in 9 months


Eligibility criteria:
inclusion criteria: * 18 years or older * ptsd diagnosis according to dsm-5 (caps-5); * ptsd diagnosis stemming from 2 or more potentially traumatic events (ptes) * seeking first-time treatment for ptsd (or less than 8 sessions); * employed (working or on sick leave for less than two years) exclusion criteria: * current psychotic disorder, severe alcohol or substance use disorder, high suicidal intent (mini-s for dsm-5) and a concrete suicide plan, or severe aggressive behavior that poses danger for others * insufficient command of the dutch language to be able to complete the assessments. this will be determined through clinical judgment at intake.

Keywords: intensive treatment massed treatment randomized controlled trial rct first time treatment
prediction of thyroid cancer from ultrasonographic characteristics of thyroid nodules

Conditions: Thyroid Nodule

Summary: the aim of this study is to identify which ultrasonographic feature or a combination of features is the best predictor of thyroid cancer in thyroid nodules.


Eligibility criteria:
inclusion criteria: * subjects with thyroid nodules over 10 mm in the longest diameter * euthyroid or hypothyroid subjects with a solitary thyroid nodule or multinodular goiter * subjects with a hypoactive nodule in the thyroid scan and a low tsh exclusion criteria: * subjects with four or more thyroid nodules that are over 10 mm * subjects with low tsh and hyperactive nodule on thyroid scan

Keywords: thyroid nodule biopsy, fine-needle
antinociceptive effect of transauricular electrical vagal nerve stimulation

Conditions: Pain, Acute

Summary: this investigation is going to study whether electrical tvns applied at the cymba of auricular conchae reduces central sensitization of experimentally induced pain in comparison with electrical sham stimulation applied at the earlobes and whether the hypoalgesic effects of tvns disappear after pharmacological block of muscarinic receptors. also, this investigation will examine whether tvns is associated with activation in brain areas, involved in processing of thermal pain stimuli and emotional and vegetative modulation of thermal pain in subjects who will respond with antinociceptive reaction to tvns.


Eligibility criteria:
inclusion criteria: * healthy volunteers aged 18-45 years old, who have given informed consent * at least two days free from consume of recreational drugs * no local infection at the site of tvns and pain stimulation exclusion criteria: * psychiatric disorders * abnormal skin conditions (infection, scars, psoriasis, eczema) at the site of tvns * contra-indications for mri (e.g. claustrophobia, pregnancy, tattoos, metallic implants) * history of coronary heart disease, cardiac arrhythmia, glaucoma, allergy to sulphates