Kornimate/medical-research-clean huggingface dataset:
evaluation of the planet nutrition program on obesity parameters in mexican schoolchildren

Conditions: Childhood Obesity

Summary: obesity prevention programs in schools are essential to promoting healthy lifestyles. there are programs with positive effects on obesity parameters, but only a few of them have didactic material for its dissemination. in united states they have effective programs (with materials for their implementation) and some are already being implemented in different schools. in mexico our study group has developed a program called "planet nutrition" that includes a manual.the main aim of this study is to evaluate the efficacy of the program "planet nutrition"-a nutrition education and behaviour change program- on bmi z score in school children compared to a control group at 9 weeks. this pilot stud is a randomized controlled trial. the study will be conducted with 41 participants. the primary outcome was the change in the bmi z score from baseline to 9 weeks. secondary outcomes were the changes from baseline to 9 weeks in body fat percentage, waist circumference, systolic and diastolic blood pressure, consumption of healthy and unhealthy food, physical activity and sedentary lifestyle, cardiorespiratory capacity and nutrition knowledge. additionally bmi z score will be measured at 23 weeks, after the summer vacations. considering evidence that this period could have a negative impact on children´s weight.

fifth grade students from a public elementary school in hermosillo, sonora, mexico were invited to participate in the program. the nutritionist team of the study made the request face to face in the classrooms. a printed invitation was delivered to be given to schoolchildren parents, in addition to the informed consent and assent along with a data questionnaire. to be included children must be in fifth grade from the chosen school and be between 9 to 12 years old. the exclusion criteria were, having or develop a medical condition, taking medication or having an intervention that affects body weight, having a condition that prevents physical activity (cardiovascular, respiratory, muscular, osteoarticular, etc.) at baseline or during the study, and withdrawal of the consent informed

Eligibility criteria:
inclusion criteria: * fifth grade students of the chosen school. * having 9 to 12 years old. exclusion criteria: * having a condition, taking medication or carrying out an intervention that affects body weight. * condition that impede physical activity including cardiovascular, respiratory, muscular and bone condition. * withdrawal of informed consent and assent. * development of a health problem or taking medication with effect on body weight during the study. * participate in another intervention or treatment for obesity management during the study.

Keywords: prevention obesity childhood school-based program lifestyle nutrition education
pregnancy outcome following global fibroid ablation using the acessa™ system

Conditions: One or More Uterine Fibroids

Summary: prospective, interventional, single-center, longitudinal, single-arm pilot study to evaluate pregnancies following the acessa™ treatment of uterine myomas in women who desire future childbearing


Eligibility criteria:
inclusion criteria: 1. are premenopausal and aged 18 to 40 years. 2. have already consented to have their fibroids treated with the acessa™ procedure. 3. desire pregnancy within two years following acessa™ treatment 4. have a normal endometrial cavity as delineated by sonohysterogram within 6 months prior to treatment. 5. have a uterine size relating to ≤14 weeks of pregnancy, as determined by palpatory pelvic exam. 6. have fibroids identified by transvaginal ultrasound with: 1. ≤6 (six) fibroids of ≤5 cm at the major diameter 2. a total uterine volume of no greater than 300 cc 7. patients with type 2 fibroids are acceptable for inclusion. 8. are current in their screening for cervical cancer precursors (i.e. pap 1 or 2). 9. are capable of providing informed consent. 10. are willing and able to comply with all study tests, procedures, and assessment tools during screening and up to 3 years post treatment. 11. are able to pass a pre-operative health exam (asa i-iii). 12. patients who are currently undergoing fertility treatments (e.g. clomid, ivf, etc.) or who are planning such treatments may be enrolled in the study. exclusion criteria: 1. have contraindications for laparoscopic surgery and/or general anesthesia. 2. have cervical myomas or type 0 or type 1 myomas. type 0 and type 1 myomas are excluded as these are generally accessible to hysteroscopic approaches. cervical myomas are difficult to treat and present a greater risk of bladder or urethral injury. 3. have one or more type 0 (completely intracavitary) or type 1 resectable submucous fibroids. 4. have known or suspected abdominal adhesions which are expected to complicate laparoscopic surgery. 5. have known or suspected untreated intra-uterine adhesions or uterine septum. 6. have previously undergone endometrial ablation, uterine artery embolization, or uterine artery ligation/occlusion, high-intensity focused ultrasound, laparoscopic, hysteroscopic or abdominal myomectomy, or any other uterine-preserving technique for reduction of menstrual bleeding. 7. subjects taking platelet-inhibiting drugs such as nonsteroidal anti-inflammatory drugs (nsaids), aspirin, and clopidogrel 8. are pregnant or lactating. 9. have known or suspected severe endometriosis. 10. have known or suspected adenomyosis. 11. have active or history of pelvic inflammatory disease. 12. have a history of or evidence of gynecologic malignancy or pre-malignancy within the past five years. 13. have had pelvic radiation. 14. have a persistent and undiagnosed complex adnexal mass.are unable to give informed consent. 15. in the medical judgment of the investigator should not participate in the study.
is osteoporosis education effective in parkinsonian patients

Conditions: Osteoporosis; Parkinson Disease

Summary: the effects of osteoporosis (op) education on op patients and the normal population studied and described in numerous studies. but the effects of op education on parkinsonian patients have not been sufficiently elucidated. the purpose of this study was to evaluate the effect of op education on the op knowledge level and daily life in parkinsonian patients. our hypothesis is; to parkinsonian patients; there is a statistically significant difference in terms of op knowledge level and daily life between giving only informative leaflets about op and also providing structured op education. 54 participants aged 50 and older with parkinson's disease were randomized to the experimental and control groups. while only leaflets were given to the control group, structured op education was also given to the experimental group. patients were evaluated with the same structured face-to-face interviews at the entrance and 12 weeks later.

the op education was performed in groups of 4-5 people by a single physician in the form of verbal expression via slide, with a duration of 20 minutes and in the form of a single session. our leaflets contained the same information as the op education program. face-to-face interviews include; revised 2011 osteoporosis knowledge test (rokt) (0-32 points) for op knowledge levels; national osteoporosis foundation daily calcium intake scale \[nof, (mg)\], physical activity scale for the elderly (pase, 0-763 points), smoking and alcohol use status (yes/no) and quantities (cigarette pack/per week, alcohol unit/per week), frequency of falls (times/last 1 month) were questioned for effects on daily life.

Eligibility criteria:
inclusion criteria: 1. male and female patients aged 50 years or older 2. being diagnosed with parkinson's disease exclusion criteria: 1. severe physical and cognitive dysability

Keywords: osteoporosis parkinson disease osteoporosis education knowledge level daily life
post- approval study on patients who received a heartware hvad® during ide trials

Conditions: Heart Failure

Summary: patients will be approached to participate in this pas after the heartware® ventricular assist system receives pma approval for the indicated use as a bridge to cardiac transplantation.

patients who participated in prior trials will be approached for this pas as follows: * patients who are on continued heartware® system support, (original or exchange device) * patients who have been explanted for transplant or recovery and have not yet completed 6 months of follow-up patients who participated in prior trials who will not be approached to participate in this follow-up study include: • patients who have been explanted for transplant or recovery and have completed at least 6 months of follow-up (documented in the prior ide trial). no new patients are being screened or implanted with the heartware® system for this trial, it is a follow-up trial only.

Eligibility criteria:
inclusion criteria: 1. the patient has participated in a prior heartware trial under ide g070199. 2. the patient was implanted with the heartware® ventricular assist system and was an active patient in the prior trial. 3. the patient has signed informed consent for participation in the study. exclusion criteria: 1. the patient is unwilling or unable to comply with trial requirements. 2. the patient did not sign the informed consent.
enhancing communication and hiv outcomes

Conditions: HIV Infections

Summary: the goal of this research is to improve communication between the patients with hiv and their health care providers. the overall purpose of doing so is to reduce disparities in medication self-efficacy, adherence to therapy, and hiv viral load suppression. the investigators will conduct a randomized controlled trial to test the effectiveness of a combined provider and patient communication intervention conducted at two separate visits compared to usual care in improving the quality of patient-provider communication, patients' medication self-efficacy, patient adherence to therapy, and hiv rna suppression.

the goal of this research is to improve communication between the patients with hiv and their health care providers. the overall purpose of doing so is to reduce disparities in medication self-efficacy, adherence to therapy, and hiv viral load suppression. we will conduct a randomized controlled trial to test the effectiveness of a combined provider and patient communication intervention conducted at two separate visits compared to usual care in improving the quality of patient-provider communication, patients' medication self-efficacy, patient adherence to therapy, and hiv rna suppression. the following primary and secondary hypotheses will be addressed. primary hypothesis. 1) there will be more and higher quality patient-provider communication about antiretroviral medication adherence in the intervention compared to control arm at both visit 1 (v1) and visit 2 (v2). secondary hypotheses 1. higher quality patient-provider communication in the intervention arm will be associated with * higher patient ratings of communication (overall, hiv-specific, adherence-specific, and interpersonal style of provider) at v1 and v2; * increased patient preference for a shared decision-making role at v1 and v2; * more positive health beliefs at v1 and v2; * higher patient medication self-efficacy at v1 and v2; * better adherence to antiretroviral medication (assessed by 3-day recall) at v2; and * a greater percentage of patients with hiv-1 rna suppression at v2. 2. the intervention will reduce disparities in medication self-efficacy, adherence, and hiv-1 rna suppression.

Eligibility criteria:
inclusion criteria (providers): 1. currently providing primary care to at least 10 hiv-infected patients in the clinic 2. physician, nurse-practitioner, or physician-assistant 3. agree to give written informed consent. inclusion criteria (patients): 1. hiv-infected patient of one of the participating providers 2. has had at least one prior visit with that provider 3. currently taking antiretroviral therapy 4. capable of understanding and giving written informed consent 5. age \> 20 years old 6. english-speaking 7. african-american (or people of african descent living in the united states), hispanic, or non-hispanic white race/ethnicity

Keywords: communication hiv/aids treatment experienced
evaluation of exotropia after patching the eye or after prism adaptation

Conditions: Exotropia

Summary: this study intends to determine the number and percent of subjects initially diagnosed with divergence excess exotropia which would be reclassified as simulated divergence excess exotropia if tested after 24 hours of monocular occlusion (patching) or after prism adaptation for the distance angle.


Eligibility criteria:
inclusion criteria: * diagnosed with divergence excess exotropia according to standard criteria (see study procedures for specifics) * no prior strabismus surgery * able to cooperate with testing (by examiner determination) * neurologically normal except for strabismus (adhd and autism spectrum are not exclusion criteria as long as the subject can cooperate for necessary testing) * not amblyopic at the time of enrollment (best-corrected visual acuity in both eyes of 20/40 or better) * under 18 years of age. there is no lower age limit as long as the subject can cooperate for the required testing. * no diagnosis of dissociated vertical deviation exclusion criteria: * no diagnosis of divergence excess exotropia according to standard criteria (see study procedures for specifics) * prior strabismus surgery * unable to cooperate with testing (by examiner determination) * diagnosed with a neurological disorder (adhd and autism spectrum are not exclusion criteria as long as the subject can cooperate for necessary testing) * best-corrected visual acuity in either eye worse than 20/40 * 18 years of age or older * diagnosed with dissociated vertical deviation
the metabolic effects of acute hyperglycemia in patients with type 2 diabetes

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of the study is to characterize the changes in amino acid, lipid and glucose metabolism in patients with type 2 diabetes exposed to acute hyperglycemia. moreover we wish to assess the effect of acute hyperglycemia on cardiac output.

cardiovascular disease is the main cause of death in modern western societies. obesity, diabetes and the metabolic syndrome are the main risk factors for cardiovascular disease. people with type 2 diabetes and no history of heart disease have a risk of myocardial infarction similar to the risk in non-diabetic patients with known heart disease. however, the causal relationship between obesity, diabetes and cardiovascular disease is unclear. insulin resistance leads to many metabolic abnormalities, including high circulating levels of free fatty acids (ffa). ffa induces insulin resistance and may lead to beta cell failure. in addition ffa may directly worsen the metabolic and electrochemical performance of the working heart. moreover it is still unclear how acute hyperglycemia affects cardiac output. in this study our purpose is to characterize the changes in amino acid, lipid and glucose metabolism in patients with type 2 diabetes exposed to acute hyperglycemia (blood glucose between 18 and 20 mmol/l) compared to the amino acid, lipid and glucose metabolism at a normal glucose level (blood glucose between 5 and 7 mmol/l). the results from the patients with type 2 diabetes will be compared with results from healthy controls examined in a fasting basal state. the patients must not suffer from any kind of serious heart disease and should be treated with insulin. moreover we wish to compare cardiac output at high and normal blood glucose levels, respectively. cardiac output will primarily be assessed by doppler echocardiography.

Eligibility criteria:
inclusion criteria: * written consent * age 40-75 years old * bmi between 22 and 35 * type 2 diabetes treated with insulin (\< 60 ie/day) exclusion criteria: * severe disease * severe cardiac disease

Keywords: type 2 diabetes dysregulation metabolism cardiac output
effect of a synbiotic supplement on a high-protein diet

Conditions: Obesity

Summary: the objective of the trial is to study how a synbiotic treatment will affect weight loss and management in individuals enrolled in weight loss diet profile®. the investigators propose to follow up 2 cohorts of profile® subjects during 6 months. one group will receive a synbiotic treatment supplement (bifidobacterium spp plus bimuno- galacto-oligosaccharides (b-gos)) while the other group will receive placebo capsules. anthropomorphic and metabolic analysis will be performed by-monthly. fecal samples will be obtained before and after the dietary intervention and samples will be sequenced trough next generation dna sequencing to analyze the gut microbiota. because dietary interventions with high protein and low glycemic index have been shown to be effective in reducing weight, but has also been linked to potential colon harm due to increased fermentation of undigested protein on the colon, the investigators expect supplementation of profile® with a synbiotic product will lead to an increased overall wellbeing without compromising weight management.

the investigators intend to recruit 40 new profile® members and to randomly divide them into 2 groups; group a will follow the conventional coaching and diet plan, while group b will also receive a daily dose of the synbiotic treatment (group a will receive a placebo supplement similar in appearance and caloric content to the synbiotic treatment). volunteers will be followed for 6 months, and weight loss, waist circumference, bmi and glucose and cholesterol levels will be assessed monthly. dual-energy x-ray absorptiometry (dxa) will be used to analyze body composition at the beginning and end of the dietary interventions. fecal samples will be obtained at the beginning and the end of the study. because both our pre- and probiotic supplements have been reported to increase the concentration of satiating bacteria-derived metabolites, we expect that the individuals on the group b (synbiotic supplement) will experience a higher weight loss as well as more significant drops in glucose and cholesterol levels. because synbiotic treatments have been reported to facilitate gi passage, the investigators expect volunteers in group b will also report improved bowels movements and general wellbeing.

Eligibility criteria:
inclusion criteria: * any individual aged 18-80 years participating in the profile weight loss/management diet exclusion criteria: * pregnant * requires special diets or dietary regimens * on long term antibiotic therapy * diagnosed with gastrointestinal diseases (irritable bowel syndrome, crohn's disease or colitis) * immune compromised * have cancer

Keywords: probiotics prebiotics synbiotics obesity
retrospective study of invasive fungal infections with filamentous fungi in heart transplant patients

Conditions: Invasive Fungal Infections

Summary: invasive filamentous fungal infections (aspergillosis, scedosporiosis, mucormycosis, fusarium wilt) are common and serious in immunocompromised subjects and particularly organ transplant patients. there is little recent data in heart transplantation, particularly on the incidence and risk factors of fungal infections. . it is therefore important to have recent data on incidence, risk and prognostic factors in order to improve the management of this severe complication.


Eligibility criteria:
inclusion criteria: * adult patient ≥18 years old * heart transplant * invasive fungal infection with filamentous fungi during the period from january 1, 2008 to december 31, 2022 * proven or probable infection with filamentous fungi according to eortc/msgerc criteria (20): * invasive aspergillosis * mucormycosis * fusarium wilt * scedosporiosis * other filamentous fungus infection * subject who has not expressed, after information, his opposition to the reuse of his data for the purposes of this research. exclusion criteria: * patient having expressed his opposition to participating in the study * patient not having a liver transplant * subject under guardianship, curatorship or safeguard of justice.

Keywords: invasive fungal infections filamentous fungi heart transplant fungal infections
er stress in nafld

Conditions: Obesity; NAFLD

Summary: the investigators overall hypothesis is that exacerbation of endoplasmic reticulum (er) stress in the liver is associated with significant alterations in phosphatidylcholines that drive the nash phenotype in obese humans. the investigators plan to examine this hypothesis in a well-characterized cohort of obese subjects that are scheduled for bariatric surgery. methyl-d9-choline chloride will be infused before and after a 2-week high fructose or glucose feeding to determine the biosynthesis and kinetics of secretory lipoprotein phospholipids. it is proposed that phospholipid metabolism play an important role in the pathogenesis or etiology of fatty liver in non-alcoholic conditions through mechanisms that invoke er and oxidative stress responses.


Eligibility criteria:
inclusion criteria: * ambulatory females age 30-60 years old * women of all ethnic groups * bmi≥35 kg/m2 * approval for roux-en-y gastric bypass or sleeve gastrectomy. exclusion criteria: * smoking \>7 cigarettes per day * previous malabsorptive or restrictive intestinal surgery * pregnant or breastfeeding * recent history of neoplasia (\<5 years ago) * malabsorptive syndromes * inflammatory intestinal disease * patients with established organ dysfunction * diagnosis of type 1 or type 2 diabetes mellitus or current use of anti-diabetic medication (last 30 days; last 60days for thiazolidinediones) * diagnosed hyperbetalipoproteinemia or hypobetalipoproteinemia * patients on cholesterol lowering medicines * vegan diet * hepatic fat content \<10% by mri * inability to comply with study protocol such as unable to make study visits or be available daily for phone contact * any condition which would interfere with mri or pet studies, e.g. claustrophobia, cochlear implant, chronic back pain limiting ability to lay flat, metal fragments in eyes, cardiac pacemaker, neural stimulator, tattoos with iron pigment and metallic body inclusions or other metal implanted in the body which may interfere with mri scanning.

Keywords: obesity nafld nash steatosis