Kornimate/medical-research-clean huggingface dataset:
complete vs culprit-only revascularization to treat multi-vessel disease after early pci for stemi

Conditions: Acute Myocardial Infarction; Coronary Artery Disease

Summary: to determine whether, on a background of optimal medical therapy, including ticagrelor, opening of all suitable narrowings or blockages found at the time of primary pci for an acute heart attack is better than treating only the culprit lesion in patients with multi-vessel disease.

to determine if a strategy of multivessel revascularization involving pci of all suitable non-infarct related artery lesions plus optimal medical therapy is superior to a strategy of optimal medical therapy alone in reducing (1) the composite outcome of cardiovascular (cv) death or new myocardial infarction (mi), or (2) the composite of cv death, new mi or ischemia driven revascularization (idr) in patients with multivessel disease who have undergone early successful culprit lesion pci for stemi.

Eligibility criteria:
inclusion criteria: 1. men and women within 72 hours after successful pci (preferably using a drug eluting stent) to the culprit lesion for stemi. pci for stemi can be either primary pci or rescue pci for failed fibrinolysis or a combination strategy where pci is performed routinely 3-12 hours after fibrinolysis and 2. multi-vessel disease defined as at least 1 additional non-infarct related coronary artery lesion that is at least 2.5 mm in diameter that has not been stented as part of the primary pci and that is amenable to successful treatment with pci and has: * at least 70% diameter stenosis (visual estimation) or * at least 50% diameter stenosis (visual estimation) with fractional flow reserve (ffr) ≤ 0.80 exclusion criteria: 1. planned revascularization of non-culprit lesion 2. planned surgical revascularization 3. non-cardiovascular co-morbidity reducing life expectancy to \< 5 years 4. any factor precluding 5 year follow-up 5. prior coronary artery bypass graft (cabg) surgery

Keywords: stemi ticagrelor multi-vessel disease culprit lesion
peanut protein supplementation to augment muscle growth and improve markers of muscle quality and health in older adults

Conditions: Aging; Sarcopenia

Summary: this study will evaluate the adaptations in skeletal muscle that occur in response to 10 weeks of weight training with or without peanut protein supplementation in older adult men and women.

aging is associated with declines in muscle mass, physical strength and physical function. adequate quality protein intake in aging adults is critical to preventing functional decline. peanuts provide a unique blend of amino acids that can provide several health benefits to aging adults. while supplementing with peanut protein (pp) powder as part of a resistance training program may increase myofibrillar protein synthesis (i.e., the gold standard molecular assessment in deciphering a muscle-building response), and improve skeletal muscle quality and body composition, no study to date has made this determination. this is a two-phase study using both novel and conventional methods to assess how pp supplementation affects muscle tissue in older individuals who engage in resistance training. these two phases will be conducted as part of a 10-week randomized controlled trial in which men and women aged 50 years and older (n=60), will be stratified by gender and randomized to a resistance training intervention (whole body, two days per week) with pp powder (72g daily; n=15 males, n=15 females) provided during the intervention (immediate group, ig) or after the intervention (wait-list control, wlc, n=15 males, n=15 females). the aims of this study are to determine the acute (deuterium oxide tracer) and chronic (peripheral quantitative computed tomography) effects of pp during resistance training on skeletal muscle myofibrillar protein synthesis rates, changes in skeletal muscle size and quality, changes in whole and appendicular body composition (dual energy x-ray absorptiometry), changes in inflammatory markers and the fecal microbiome.

Eligibility criteria:
inclusion criteria: * body mass index (body mass/height squared) less than 35 kg/m2 * resting blood pressure averaging less than 140/90 mmhg (with or without medication) exclusion criteria: * known peanut allergy * actively participating in resistance training for more than 2 days/week * any known overt cardiovascular or metabolic disease * metal implants that will interfere with x-ray procedures * medically necessary radiation exposure in the last six months (except dental x-ray) * any medical condition that would contradict participating in an exercise program, giving blood or donating a skeletal muscle biopsy (i.e. blood clotting disorder or taking blood thinners)

Keywords: muscle protein synthesis resistance training protein supplementation skeletal muscle physiology inflammatory cytokines fecal microbiome plant protein
outcome of patients undiagnosed under medical thoracoscopy

Conditions: Pleural Diseases

Summary: medical thoracoscopy (mt) under local anaesthetic and mild sedation, an established method in the diagnosis of pleural diseases. mt has an overall diagnostic yield above 90% for malignant pleural diseases and pleural tuberculosis. however, others who are diagnosed as fibrinous pleuritis make confusion in clinicians. whether these patients are firmly followed or not ? the investigators do not know the answer of this question. in this study the investigators aimed to investigate the outcome of the patients who are diagnosed as fibrinous pleuritis on mt biopsies.

medical thoracoscopy (mt) under local anaesthetic and mild sedation, an established method in the diagnosis of pleural diseases with a sensitivity above 90% and specificity of 1000% for malignant pleural diseases and pleural tuberculosis. except these two groups of patients, in others pleural histopathological diagnosis is defined as "non-specific pleuritis" or "fibrinous pleuritis". authors say that the natural evolution of these patients is poorly understood. some of these patients was later established false negative cases for malignant pleural diseases. clinical guidelines recommend close observation of patients with undiagnosed exudative effusions, although the length and follow-up regime is not defined, yet. in this study the investigators examine the outcome of patients who are diagnosed as fibrinous pleuritis by mt.

Eligibility criteria:
inclusion criteria: * undiagnosed exudative pleural effusion * under 20 years-old, over 85 years-old * followed 2 years at least exclusion criteria: * transudative pleural effusion * patients who do not accepted medical thoracoscopy.

Keywords: medical thoracoscopy pleural effusion malignant pleural diseases tuberculous pleuritis fibrinous pleuritis
effect of kinesio taping application in addition to pilates exercises on core muscle thickness, cognition and mental fatigue in individuals with non-specific low back pain

Conditions: Low Back Pain; Non Specific Low Back Pain

Summary: low back pain is a common problem. in low back pain, the core region and posture are frequently affected. however, no definitive decision has been reached regarding cognition and mental fatigue. in the treatment of low back pain, exercise and kinesio taping approaches are frequently used. the aim of this study is to evaluate the effects of kinesio taping applied in addition to pilates exercises on pain, core muscle thickness, strength and endurance, posture, cognition and mental fatigue in individuals with non-specific low back pain and to compare it with placebo taping and the control group. the primary outcome measure of this study is core muscle thickness, while other measurements will be considered as secondary outcomes.


Eligibility criteria:
inclusion criteria: * • having back pain of at least 3 out of 10 points on the visual analog scale, * being between the ages of 30-55, * having back pain for at least 1 month, * having been tested with a test piece beforehand and not having an allergy to kinesio taping. exclusion criteria: * • having had surgery for back pain, * not complying with treatment, * having a neurological deficit, * having a body mass index over 30, * having a positive straight leg raising test, * having a positive slump test, * having a positive bowstring test, * being pregnant, * having received any treatment for back pain in the last month, * doing regular exercise in the last month.

Keywords: low back pain kinesio tape pilates core cognition mental fatigue
atopy patch test in children with atopic dermatitis

Conditions: Atopic Dermatitis; Food Allergy

Summary: positive reactions in atopy patch test in children with atopic dermatitis.

the prevalence of food allergy seems to be increasing, which might explain the increased demand for reliable evaluation of patients with suspected food-related gastrointestinal symptoms. little is known about the diagnostic accuracy of atopy patch tests(apt) in the clinical practice. apt seems to have a better specificity than the ige methods and seems to reflect late-phase clinical reactions.the aims of this study were to evaluate: (i) the prevalence of positive reaction of apts for atopic dermatitis (ii)positive reaction of apt compare with skin prick test. (iii)positive reaction of apt using lyophilized food vs commercially available food extracts. (iv)side effect or adverse

Eligibility criteria:
inclusion criteria: * patients who had history of atopic dermatitis exclusion criteria: * who have dermographism * who have chronic disease eg. autoimmune disease, immune deficiency, cancer or allergic disease * pregnant women * who receive antihistamine, topical steroid and systemic steroid \> 20 mg/day within 7 days prior study

Keywords: atopic dermatitis atopic patch test
comparison of two laser therapy methods for pdr

Conditions: Proiriftrative Diabetic Retinopathy

Summary: proliferative diabetic retinopathy (pdr) is treated with conventional pan retinal photocoagulation (prp) which can improve the visual prognosis in this complication significantly. however , the treatment may also resulting adverse effects such as blurring of central vision, visual field constriction and disturbance in dark adaptation and contrast vision. extended targeted retinal coagulation (trp) to the ischemic areas may cause regression of the neovascularization while minimizing some of the risks and complication associated of treatment of pdr with these two methods.


Eligibility criteria:
inclusion criteria: * patients with pdr condidate for photocoagulation teraphy * pupil with dilatasion≥6mm * without privious treatment with anti vegf drugs 3months before study * without privious vitroretinal sugery * without privoius lasertraphy exclusion criteria: * to have nvi cricteria with increase of inraocular pressure * to have cataract or vitrus leakage which prevent lasertraphy * pupil smaller that 6mm * traditional retinal detachment * privious treatment with anti vegf drugs 3months before study * privious prp * patient unable to get wide field fag
ocular surface disease changes after istent or istent inject implantation with phacoemulsification

Conditions: Ocular Surface Disease; Glaucoma, Open-Angle

Summary: this prospective interventional single-arm trial evaluates measures changes in ocular surface disease parameters in eyes with mild to moderate open-angle glaucoma (oag) on 1-4 glaucoma medications who undergo phacoemulsification and trabecular micro-bypass stent(s) implantation (istent or istent inject).

this study enrolled eyes with mild to moderate open-angle glaucoma (oag) on 1-4 glaucoma medications who were scheduled to undergo phacoemulsification cataract extraction and trabecular micro-bypass stent(s) implantation (istent or istent inject). study participation entailed measurement of key ocular surface data through 3 months postoperative including ocular surface disease index score (osdi), corneal/conjunctival staining (oxford schema), fluorescein tear break-up time (ftbut), and conjunctival hyperemia (efron scale); these measures were collected alongside standard postoperative glaucoma evaluations such as number of glaucoma medications and intraocular pressure (iop).

Eligibility criteria:
inclusion criteria: 1. mild to moderate primary open-angle glaucoma 2. currently treated with ocular hypotensive medication 3. primary open-angle, pseudoexfoliative and pigmentary glaucoma are acceptable diagnoses 4. subject scheduled to undergo cataract surgery in combination with one trabecular meshwork bypass stent 5. 22 years of age or older 6. able and willing to attend scheduled follow-up exams for three months postoperatively 7. able and willing to provide written informed consent on the irb approved informed consent form 8. successful, uncomplicated cataract surgery 9. osdi of 8 or more exclusion criteria: * 1. primary angle-closure glaucoma; or secondary angle closure glaucoma, including neovascular glaucoma 2. any pathology for which, in the investigator's judgement, the following would be either at risk or contraindicated: 1. cataract surgery 2. stent implantation 3. compliance to elements of the study protocol (e.g., ophthalmic examinations, follow-up visits) 3. fellow eye actively enrolled in this trial 4. current participation in any study, or participation within 30 calendar days of screening exam 5. unsuccessful, complicated cataract surgery 6. osdi of 7 or less

Keywords: ocular surface dry eye medication quality of life
telerehabilitation-based yoga and mindfulness home program in postmenopausal women having social isolation

Conditions: Telerehabilitation

Summary: in the postmenopausal period when the woman spent 1/3 of her life; due to the lack of estrogen, some physical and psychological changes occur. these changes may cause some problems. for women who perceive menopause as the first step of old age, loss of physical strength, energy, attraction and fertility, menopause can also lead to anxiety. in addition to these, they are among the emotional changes in the menopausal period in symptoms such as hypersensitivity to events, fatigue, and insomnia. sometimes it can even be seen in psychological disorders such as melancholy and depression. the new coronavirus pneumonia (covid-19), which appeared in wuhan in december 2019, started to appear in different countries soon after. all countries have taken measures to prevent the spread of this virus. to this end, turkey remains at home on march 21, 2020, and has commissioned social isolation measures. studies investigating the effects of social isolation show that psychological and physical problems occur in individuals. studies have shown that yoga and mindfulness programs have an impact on people's anxiety, depression, and the ability to control themselves. the purpose of this study; to investigate the effectiveness of telerehabilitation based yoga and mindfulness programs on psychological resilience, physical awareness and physical activity in postmenopausal women in social isolation due to the covid-19 outbreak. using telerehabilitation-based home programs aims to use an innovative model.


Eligibility criteria:
inclusion criteria: * being physically or perceptually competent to exercise, * no spinal pathology or deformity, * volunteering to participate in the study, * not having menstruation for at least 12 months * hormonally, surgically induced or natural menopause-confirmed women exclusion criteria: * those with serious heart disease (aortic stenosis, angina, hypertrophic cardiac myopathy, arrhythmia, pacemaker) * those with inflammatory or systemic disease malignancy * psychological dysfunction * those who use corticosteroids

Keywords: postmenopausal yoga mindfulness covid-19 social isolation
internet-based relapse prevention vs face to face therapy at an employee assistance program

Conditions: Alcohol Abuse; Alcohol Addiction

Summary: objectives: this study will evaluate the efficacy of internet-based relapse prevention with therapist support, as compared to face-to-face therapy at an employee assistance program. the design is a two-armed randomized controlled design, and outcomes are measured in terms of changes in problematic alcohol use, as well as depression and quality of life. method: participants with problematic alcohol use who, after an initial evaluation consisting of five face-to-face sessions with a licensed psychologist where alcohol and collateral problems are extensively assessed, are recommended treatment for problematic alcohol use. consenting participants will be randomized into one of two groups: 1. internet delivered relapse prevention with therapist support or 2. face-to-face therapy. outcomes on alcohol use, depression and quality of life as well as information on user satisfaction will be gathered post treatment. follow up will be at 3, 6 and 12 months after completion. our hypothesis is that the internet-based program with therapist support and the face-to-face therapy will be equally effective in reducing alcohol use (non-inferiority).


Eligibility criteria:
inclusion criteria: problematic alcohol use and having been recommended psychotherapy by the assessing psychologist. exclusion criteria: inadequate swedish language skills no internet access reading and/or writing difficulties major depression current suicidal thoughts and/or plans primary problematic drug use ptsd-related problems psychosis cognitive disability

Keywords: randomized controlled trial alcohol internet internet based therapy cognitive behavioral therapy
morbimortality of covid-19 in patients with chronic inflammatory rheumatism treated with immunosuppressants

Conditions: Sars-CoV2; Rheumatoid Arthritis; Rheumatic Diseases

Summary: a retrospective monocentric study with large active files of patients monitored for rheumatoid arthritis, spondyloarthritis and systemic lupus erythematosus with as main endpoint the morbimortality of covid-19 in these patients (number of patients hospitalized in conventional units and/or in intensive care and/or deceased). the results will be compared with those of the general population based on the epidemiological data of covid-19.


Eligibility criteria:
inclusion criteria: * patients with rheumatoid arthritis on conventional synthetic dmard (csdmards) +/- biological dmard (bdmards) or targeted synthetic dmard (tsdmards) +/- corticosteroid therapy meeting acr/eular 2010 classification criteria * patients with spondylarthritison biological dmard or targeted synthetic dmard +/- conventional synthetic dmard +/- non-steroidal anti-inflammatory drugs meeting asas classification criteria * patients with systemic lupus erythematosus on hydroxychloroquine +/- conventional synthetic dmard +/- corticosteroid therapy +/- biological dmard meeting acr/eular 2019 classification criteria exclusion criteria: -

Keywords: immunotherapy chronic inflammatory rheumatism
effect of lactobacillus rhamnosus gg and bifidobacterium longum in children aged 3 to 5 years of villavicencio and pasto

Conditions: Caries, Dental

Summary: the objective of this pilot study is to determine if the presence of bacteria with probiotic characteristics (lactobacillus rhamnosus gg and bifidobacterium longum) in a commercial milk, control some measures that indicate cariogenic processes.

dental caries is a disease caused by a shift in ph balance, resulting in the formation of a biofilm composed mainly of cariogenic microflora. the interaction between this microflora and host factors conditions the deceleration or acceleration of the disease. some biotechnology tools have been tried based on all this research, including probiotics, intended for a selective control of the etiological agents of caries and the maintenance of oral homeostasis. methodology: in this study, preschool children belonging to public preschool in villavicencio and pasto, colombia will be invited to participate. after obtaining parent´s informed consent, the children will start commercial milk (nanpro3 nestlé) intake without probiotic for 3 months. one week after, they will start commercial milk with probiotic during others 3 months. clinical and microbiological testing of saliva at baseline, 3 m, and 6m will be performed. differences in salivary ph (before and after a sugar solution), remineralization and demineralization in early stage decay and established decay tooth (according to icdas) and quantification of streptococci of the mutans group. expected results: statistically significant decrease in ph drop, demineralization in decay tooth and quantification of streptococci of the mutans group.

Eligibility criteria:
inclusion criteria: * pre-school children from age 3 to 5. * healthy children from a general health perspective, with early stage decay and established decay exclusion criteria: * children with systemic disorders who need special care and / or who have intolerance to milk drinks or allergy to any of the components of the experimental and / or placebo beverage. * children who don't like milk. * children whit severe decay

Keywords: probiotic child care, dental
mobilization with movement for shoulder impingement

Conditions: Shoulder Impingement Syndrome

Summary: controversy exists regarding the effectiveness of manual therapy techniques for the management of impingement syndrome. however, no adequately powered clinical trials have examined the effects of mobilization-with-movement. the purpose of the current study was to perform a randomized controlled trial comparing the effects of real mwm to a group receiving a sham intervention on shoulder pain at different moments and active shoulder range of motion in an adequately powered sample of patients with shoulder impingement syndrome.


Eligibility criteria:
inclusion criteria: * history of shoulder pain of \> 3months duration * pain localized at the proximal anterolateral shoulder region * medical diagnosis of shoulder impingement syndrome * at least 2 positive impingement tests including neer, hawking, or jobe test exclusion criteria: * diagnosis of fibromyalgia * pregnancy * a history of traumatic onset of shoulder pain * other histories of shoulder injury * ligamentous laxity based on a positive sulcus test and apprehension test * numbness or tingling in the upper extremity * previous shoulder or cervical spine surgery * corticosteroid injection on the shoulder within 1 year of the study * physical therapy 6 months prior to the study

Keywords: shoulder impingement, manual therapy, pain, motion.
the effect of periodontal health on smile

Conditions: Smiling; Gingival Diseases

Summary: anamnesis was taken from 108 patients aged 18-33 who applied to the clinic and met the inclusion criteria. photographs of the patients' smiles were taken without any measurement. plaque , gingival index , bleeding on probing, pocket depth measurements, clinical attachment, and gingival recession levels were measured, respectively. patients were divided into two groups: peri-implant health and gingivitis. gingival thickness and keratinized gingival width were also measured. in addition, the smile aesthetic index, style, type, and stage were also determined using the smile classification system. gingival visibility was measured in mm from the photographs taken.


Eligibility criteria:
inclusion criteria: * no systemic disease exclusion criteria: * active smoking, * ongoing or past orthodontic treatment, * pregnancy, * nursing, * individuals who have drug-induced gingival hyperplasia, hereditary gingival fibromatosis, permanent or removable prostheses in the upper front area, or missing teeth in the front region

Keywords: gingivitis periodontal health smile