Kornimate/medical-research-clean huggingface dataset:
postoperative analgesia in cesarean delivery

Conditions: Postoperative Pain

Summary: i̇n this study, planned to compare the post-operative analgesic efficacy of ilioinguinal iliohypogastric (ii-ih) nerve block and quadratus lumborum iii block in elective cesarean section operations. this study primary aim is; to compare and evaluate the first rescue analgesia requirement times after quadratus lumborum iii and ii-ih block for postoperative analgesia after elective cesarean section operations under spinal anesthesia. our secondary aims are: 1. to compare the amount of total analgesic use in the first 24 hours in patients 2. to compare the nrs (numering rating scale) values (resting and dynamic) at 2. 4. 8. 12 . 24. hours in the postoperative follow-up of the patients 3. comparing the side effects such as postoperative nausea and vomiting

patients who underwent elective cesarean section under spinal anesthesia will be divided into two groups at the end of the operation, using the closed envelope randomization method as quadratus lumborum iii and ii-ih nerve block. spinal anesthesia will be applied to all patients who will undergo elective cesarean section. at the end of the operation, they will be taken to the postoperative block room. all blocks will be performed by the same anesthesiologist under usg guidance. 20 ml of 0.25% bupivacaine will be used in the blocks. all patients will be followed in the block room for 30 minutes after the block application. patients with a modified aldret score above 8 will be sent to the service because they are under spinal anesthesia at the end of the operation.at the end of the operation, when the spinal level regresses to two dermatome levels, paracetamol 1gr iv will be administered to all patients for post-op analgesia.postoperative analgesia was planned for the patients as paracetamol 4x1 gr. tramadol hydrochloride 1mg/kg was planned as rescue analgesia in the ward for patients with nrs scores greater than 3 in their postoperative follow-up. patients 2.,4.,8.,12.,24. hours will be followed by an anesthesia assistant who is different from the researcher who applied the block and who is blind for the study. the patients' first rescue analgesia times, nrs scores, postoperative side effects, and total analgesic amounts used in 24 hours will be recorded.

Eligibility criteria:
inclusion criteria: * patients aged between 18 and 40 * asa 2 risk group * patients at 37-41 weeks of pregnancy * undergoing cesarean section under spinal anesthesia exclusion criteria: * the patient does not accept the procedure. * patients with a history of eclampsia and preeclampsia during pregnancy * local anesthetic allergy * infection at the procedure site * anticoagulant use with bleeding disorder * chronic analgesia and opioid use * mental, psychiatric and neurological problems * patients with asa 3 and above with a history of any chronic disease.

Keywords: cesarean section quadratus lumborum iii block ilioinguinal iliohypogastric block analgesia
the effect of acupressure on fatigue in individuals with chronic fatigue syndrome

Conditions: Acupressure; Fatigue Syndrome, Chronic; Complementary Therapies; Quality of Life; Depression

Summary: chronic fatigue syndrome is a common problem in society. the treatment of this problem is limited. acupressure is a treatment method that has become widespread and promising in recent years. for this purpose, the effect of acupressure treatment on chronic fatigue syndrome was investigated.

this study aimed to determine the effectiveness of acupressure technique in individuals with chronic symptoms. in our study, individuals participating in the study will be randomized by the physiotherapist who has received the training of acupressure therapy. the study will be done for a total of 10 sessions for 4 weeks. individuals' fatigue levels will be measured by fatigue severity scale, their quality of life will be measured by short form-36 and depression levels by beck depression inventory. evaluations will be made at the beginning and at the end of the treatment.

Eligibility criteria:
inclusion criteria: * 20-45 year old * not using any medical treatment, * not being included in any physiotherapy program in the last 3 months, * does not have any systemic disease, * spending at least 4 hours at the computer or desk during the work exclusion criteria: * fibromyalgia * rheumatoid arthritis * open wound * skin failure

Keywords: acupressure fatigue syndrome, chronic, complementary therapies
comparative study of autologous blood injection versus diluted epinephrine in treating actively bleeding gastroduodenal ulcers

Conditions: Blood, Injection, Injury Type Phobia; Gastrointestinal Ulcer Haemorrhage; Adverse Reaction to Epinephrine

Summary: endoscopic injection of autologous blood can control bleeding from gastroduodenal ulcers.

to test the hypothesis that endoscopic injection of autologous blood is superior to endoscopic injection of diluted epinephrine in controlling bleeding from gastroduodenal ulcers.

Eligibility criteria:
inclusion criteria: * all adult patients with gastroduodenal ulcer exclusion criteria: * patients with non ulcer bleeding. * patients with malignancy. * patients with bleeding disorders or under coagulation therapy. * patients with known allergy to epinephrine.

Keywords: autologous blood epinephrine endoscopy ulcer hemostasis
radiation therapy in treating patients with stage ii or stage iii prostate cancer

Conditions: Prostate Cancer

Summary: rationale: radiation therapy uses high-energy x-rays to damage tumor cells and may be an effective treatment for prostate cancer. purpose: phase i/ii trial to study the effectiveness of radiation therapy in treating patients who have previously untreated stage ii or stage iii prostate cancer.

objectives: i. determine the maximum tolerated dose of 3-dimensional conformal radiotherapy to the prostate gland and immediately surrounding tissues in patients with stage ii or iii adenocarcinoma of the prostate. ii. determine the normal tissue toxicity rate of this regimen in the rectums and bladders of these patients. iii. determine local control by clinical and pathologic examination and by psa determinations in patients treated with this regimen. iv. determine the distant failure and overall survival of patients treated with this regimen. outline: this is a dose escalation study. patients are stratified according to 1 of the following 3 prognostic groups: group 1: t1b-c or t2a-b with combined psa/gleason (cpg) score 15 and under group 2: t1b-c or t2a-b with cpg score more than 15, or any t2c with psa less than 70 ng/ml group 3: t3 with prostate specific antigen (psa) less than 70 ng/ml patients receive 3-dimensional (3-d) conformal radiotherapy 5 days a week for 7.6, 8.2, or 8.8 weeks. cohorts of 120-270 patients receive escalating doses of 3-d conformal radiotherapy until the maximum tolerated dose (mtd) is determined. the mtd is defined as the dose preceding that at which 20% of patients experience dose-limiting toxicity. patients are followed every 3 months for 1 year, every 4 months for 1 year, every 6 months for 3 years, and then annually thereafter. projected accrual: a total of 549-801 patients (120-204 patients for the first dose level, 237-321 patients for the second dose level, and 192-276 patients for the third dose level) will be accrued for this study within 4.75 to 5.25 years.

Eligibility criteria:
disease characteristics: previously untreated adenocarcinoma of the prostate t1b-c or t2a-b with a gleason score more than 5 and psa greater than 4 ng/ml or any t3 psa under 70 ng/ml within 3 weeks prior to entry and at least 10 days after prostate biopsy no biopsy proven regional nodal involvement no distant metastases patient characteristics: age: 18 and over performance status: karnofsky 80-100% hematopoietic: white blood cell (wbc) count of at least 4,000/mm3 platelet count at least 100,000/mm3 hemoglobin at least 11 g/dl hepatic: not specified renal: not specified other: no major medical or psychiatric illness that would preclude study no other malignancy within the past 5 years prior concurrent therapy: biologic therapy: not specified chemotherapy: no prior or concurrent chemotherapy endocrine therapy: prior hormonal therapy allowed radiotherapy: no prior pelvic irradiation surgery: no prior prostatectomy or cryosurgery for prostate cancer

Keywords: adenocarcinoma of the prostate stage iib prostate cancer stage iia prostate cancer stage iii prostate cancer
effect of animated video on comprehension and implementation feasibility

Conditions: Knowledge, Attitudes, Practice

Summary: the aim of this study is to evaluate the effects of a brief web-based educational intervention on improving anterior cruciate ligament (acl) injury prevention comprehension and implementation feasibility among coaches of athletes participating in landing and cutting sports (e.g., soccer, basketball, football, etc.). the two main hypotheses are that, compared to both an active and placebo control group, the brief animated video will produce greater improvements in: 1. overall comprehension of acl injury risk and mitigation: placebo control group \< active control group \< intervention group. 2. feasibility of utilizing acl injury prevention strategies: placebo control group \< active control group \< intervention group. exploratory hypothesis: the brief animated video will produce greater improvements in various subcomponents of comprehension-specifically: basic acl knowledge, risk knowledge, prevention knowledge and severity knowledge compared to both active and placebo control group conditions.

this study is a computer-based, three-arm pre-post randomized control design trial. participants were randomized into an intervention group, active control group or passive control group on a 1:1:1 ratio by a computer-generated algorithm embedded within the qualtrics software (qualtrics, provo, ut). sports coaches of youth and adolescent athletes in various landing and cutting sports (e.g., soccer, basketball, volleyball, etc.) in the united states were recruited and invited through qualtrics' panelists. the intervention group was shown a three-minute animated video consisting of various information components aimed at improving capability, motivation and opportunity to implement acl injury prevention strategies. the active control group received commonly accessed information from a webmd web-based article on acl injury prevention. the placebo control group intervention received an educational video from the cdc about concussions that is comparable in duration to that of the acl video. overall acl comprehension-composed of basic acl knowledge, risk knowledge, prevention knowledge, and severity knowledge-as well as implementation feasibility were all measured prior to and immediately following the interventions.

Eligibility criteria:
inclusion criteria: * sports coaches of youth and adolescent athletes in various landing and cutting sports (e.g., soccer, basketball, volleyball, etc.) in the united states. exclusion criteria: * non sport coach or coach of non-landing and cutting sport (e.g., golf, swimming).

Keywords: multimedia education information knee coach learning
a study on postmarketing xuezhikang capsule for treating dyslipidemia

Conditions: Dyslipidemia

Summary: dyslipidemia contributes greatly to the formation and progression of atherosclerosis (as), which plays a dominant role in leading to chd. xuezhikang is a partially purified extract of fermented red yeast rice (monascus purpureus). it is composed of 13 kinds of natural statins, unsaturated fatty acids, ergosterol,amino acids, flavonoids, alkaloid, trace element, and so forth. xuezhikang has been recommended in a guideline for china adult dyslipidemia prevention. this study aims to evaluate the benefit and side effect of xuezhikang, a potential alternative drug of statins, for patients with dyslipidemia, and thus provide further evidence for clinical application.


Eligibility criteria:
inclusion criteria: 1. age: 18 years to 75 years 2. patients with dyslipidemia should be diagnosed according to standard western medicine diagnosis criteria 3. tcm syndrome of patients with dyslipidemia should be diagnosed according to standard tcm syndrome diagnosis criteria 4. patients who have taken lipid lowering drugs should stop taking for at least two weeks before taking part in this study 5. patients agree to participate in this study and signed the informed consent form exclusion criteria: 1. pregnant (positive pregnancy test within 7 days of starting treatment), or lactating women. 2. patients with homozygous familial hypercholesterolemia 3. patients with known allergy to chinese medicine or any other drug 4. patients with acute myocardial infarction, cerebrovascular accident , severe trauma , major surgery and cancer in half a year. 5. ast or alt level increases at least twice the upper limits of normal in patients 6. patients who are taking part in other clinical trials that will influence the results of this study

Keywords: xuezhikang dyslipidemia chinese medicine rct
docetaxel, gemcitabine and pazopanib as treatment for soft tissue sarcoma

Conditions: Stage III Adult Soft Tissue Sarcoma

Summary: chemotherapy treatment with docetaxel and gemcitabine is a standard treatment for patients with soft tissue sarcoma. this study is designed to explore whether the addition of tyrosine kinase inhibitor pazopanib enhances the anticancer effect of the chemotherapy drugs. the phase i component of this study is designed to determine the maximum tolerated dose of pazopanib when given with docetaxel and gemcitabine. the phase ii component is designed to determine the overall response rate of the combination of docetaxel, gemcitabine and pazopanib prior to surgical resection in patients with soft tissue sarcoma.


Eligibility criteria:
inclusion criteria: * 18 years or older * chemotherapy naive, histologically high grade soft tissue sarcoma that is considered to be operable * tumor greater than 5 cm in longest dimension * life expectancy of at least 6 months * zubrod performance status of 0-2 * signed informed consent * adequate bone marrow function defined by: 1. absolute peripheral granulocyte count of \>1500 cells/mm\^3 2. hemoglobin \>8.0 g/dl 3. platelet count \>100,000/mm\^3 4. absence of a regular red blood cell transfusion requirement * adequate hepatic function defined by: 1. total bilirubin \<1.5 x upper limit of normal (uln) 2. ast, alt and alkaline phosphatase all not more than 2.5 x uln * adequate renal function defined by: 1. serum creatinine \<1.5 x uln * negative pregnancy test for women of child bearing potential * willingness to use effective contraception while on treatment and for 3 months thereafter exclusion criteria: * multiple metastases (patients with 5 or fewer oligometastases that could be resectable are eligible) * pregnant women or nursing mothers * concurrent chemotherapy or radiation therapy * severe medical problems (at the discretion of the investigator) * history of severe hypersensitivity reaction to docetaxel or other drugs formulated with polysorbate 80 * symptomatic brain metastases * cirrhosis * dermatofibrosarcoma protuberans (dfsp), embryonal rhabdomyosarcoma or alveolar soft part sarcoma (asps)

Keywords: soft tissue sarcoma gemcitabine docetaxel pazopanib
isolation and establishment of gustatory cell lines in patients operated on for cancer of the mobile tongue - immorttastecell

Conditions: Cancer of the Tongue

Summary: in terms of incidence, cancer of the tongue is one of the leading cancers in france. moreover, this cancer is associated with physiological complications ranging from swallowing disorders to loss of taste. following surgery, impaired perception of food taste may lead to cachexia. it is therefore necessary to carry out research in the field of impaired taste, notably with regard to the regeneration of taste buds. however, there is currently no available functional model of taste bud cells. it is therefore necessary to obtain a cell line of human taste cells. these immortalised human cells will allow us to better orient our investigations for applications in humans: search for and characterisation of "taste modifiers" synthesised using organic chemistry, able to trigger the perception of food in cases of taste loss or taste impairment. moreover, given recent studies conducted by the investigating team proposing the existence of a fatty taste and its implication in obesity, the work of the team could be oriented towards the synthesis of lipid-receptor agonists, by analogy with artificial sweeteners instead of sugar. the availability of these chemical molecules would lead to a reduction in lipid intake as these agents contain no (or very few) calories. they will act as an organoleptic decoy.


Eligibility criteria:
inclusion criteria: * between 18 and 70 years old, * with cancer of the mobile tongue * requiring surgery exclusion criteria: - chronic smokers
effect of transcranial direct current stimulation associated with aerobic exercise training for patients with fibromyalgia

Conditions: Fibromyalgia

Summary: this study consists of a randomized, double-blind, clinical trial with two months' duration of follow-up. the variable used was the vas for pain, considering the values of any difference between the data before and after stimulation.

the average between the analyzed values was 1.20, with a standard deviation of 0.84, taking into account a type i error of 5%, a type ii error of 10% and a power of 80%. from the sample calculation was found an n = 10 for each group. the sample is amplified in order to avoid possible effects of dropout ending with a n = 15 in each group with a total n = 45. randomization was performed by a blinded therapist using sealed envelopes for each individual. the subjects will be divided into three intervention groups: tdcs (tdcs - dc stimulator, neurocom, germany) / ae group, in which will receive active intervention of aerobic exercise training and active tdcs intervention. ae group, which will receive active intervention of aerobic exercise and placebo tdcs. and tdcs group, which will receive placebo ae and active intervention for tdcs. participants will be blinded to the intervention groups as well as therapists involved in the evaluation process. the evaluation methods were carried out one week before the beginning of the intervention (baseline) for all variables. after the first week of intervention (neuromodulatory period) was performed ratings for level of cortical excitability (t1), and after the end of the one month period of intervention for all variables (t2). follow-up evaluations were conducted one month (t3) and two months (t4) after the end of the intervention period."

Eligibility criteria:
inclusion criteria: 1. patients diagnosed with fibromyalgia according to the american college of rheumatology 2. have completed high school 3. age between 18 and 65 years old exclusion criteria: 1. were on medication for pain control for less than two months 2. in treatment of depression for less than two months 3. patients with epilepsy, psychiatric disorders or who have any recent episode of neurologic disorders such as idiopathic syncope 4. pregnant women and infants 5. possessing metallic implant in the brain 6. in use of illicit drugs 7. that were in some kind of physical treatment for less than two months

Keywords: transcranial direct current stimulation exercise fibromyalgia
pain control in children and adolescent after thoracic surgery: the effect of gabapentin

Conditions: Pain, Postoperative; Surgery, Thoracic

Summary: the study is performed in patients aged 5-18 years after thoracic surgery. the primary aim of this trial is to determine whether the use of gabapentin as a component of multimodal analgesic regiments reduces pain scores following thoracic surgery in pediatric patients. the secondary objective of the trial are to evaluate whether the use of gabapentin reduces postoperative anxiety scores and consumption of ropivacaine with fentanyl, decreases side-effects, and improves patient satisfaction.

the subjects are randomized to the gabapentin or placebo group. all patients receive preoperative gabapentin (15 mg/kg, treatment) or placebo, respectively and after surgery either gabapentin (7,5 mg/kg, treatment) or placebo 2 times per day for 3 days, respectively. patients are subjected to the same anaesthesia protocol. postoperative analgesia are achieved with either continuous ropivacaine 0.2%/fentanyl 5.0 μg/ml infusion through a thoracic epidural catheter (n=40; gabapentin n=20, placebo n=20), or intravenous infusion of morphine (n=40; gabapentin n=20, placebo n=20). all patients receive acetaminophen and non-steroidal anti-inflammatory drugs, and metamizol as a "rescue drug" the intravenous infusion of morphine grup was expanded on the basis of the bioethics commission's decision kb-125/2019 (n=64; gabapentin n=32, placebo n=32).

Eligibility criteria:
inclusion criteria: * 5 - 18 years of age; * surgery: lateral thoracotomy or ravitch procedure; * asa 1-3; * postoperative analgesia: thoracic epidural analgesia or intravenous infusion of morphine. exclusion criteria: * allergy or sensitivity to gabapentin; * history of chronic pain or daily analgesic use; * diagnosed with psychiatric disorders; * treated oncologically; * with impaired verbal communication; * the lack of postoperative chest drainage.

Keywords: postoperative pain anxiety postoperative complications patient satisfaction
conservative versus operative treatment of displaced neck fractures of the fifth metacarpal

Conditions: Fifth Metacarpal Neck Fracture

Summary: this is a prospective, randomized, multi-center pilot study of isolated, displaced neck fractures of the fifth metacarpal. the patients are randomly assigned to osteosynthesis with antegrade intramedullary splinting or conservative treatment.

the aim of this study is to provide criteria for treatment decisions in patients with isolated, displaced neck fractures of the fifth metacarpal. the primary outcome criterion is the functional status measured by the disability of the arm, shoulder and hand (dash) questionnaire. secondary outcome criteria are pain, range of motion (rom), grip strength, and radiological parameters.

Eligibility criteria:
inclusion criteria: * displaced neck fracture of the fifth metacarpal (at least 30° angulation) * isolated injury * age between 18 and 75 years * informed consent exclusion criteria: * rotational displacement * open fracture * injury older than one week * treatment other than within this study * other relevant injuries of the upper extremities * other injury or disease of the hand * pregnancy * missing informed consent * incompliance * coagulopathy * allergy to metallic implants * patients who have participated in any other device or drug clinical trial within the previous month

Keywords: neck fracture of the fifth metacarpal displacement antegrade intramedullary splinting conservative treatment