Kornimate/medical-research-clean huggingface dataset:
effect of bilateral tens with tot on upper limb function in patients with chronic stroke

Conditions: Stroke

Summary: on the basis that the combined use of uni-tens and trt is an effective intervention in upper limb recovery, and the advantage of bi-tens eliciting extra neural pathway in the intact hemisphere to facilitate the motor recovery, there is a research gap in whether the bi-tens over both the paretic and non-paretic limbs could probably augment the treatment effects of tot in upper limb motor control in people with stroke.

the purpose of this study is to determine whether bi-tens+tot was superior to uni-tens+tot, placebo-tens+tot alone and no active treatment in improving the upper limb motor control and upper limb function and community integration in people with chronic stroke. the null hypothesis will be that bi-tens+tot is not significantly different from uni-tens+tot,placebo-tens+tot alone and no active treatment in improving the upper limb motor control and upper limb function and community integration in people with chronic stroke.

Eligibility criteria:
inclusion criteria: * subjects will be recruited from local self-help groups through poster advertising. * subjects will be included if they are between 50 and 80 years of age * have been diagnosed with ischaemic brain injury or intracerebral hemorrhage by mri or computed tomography within the previous 1 to 10 years * have volitional control of the non-paretic arm and at least minimal antigravity movement in the shoulder of the paretic arm, * have at least 5º in wrist extension in the antigravity position, * score \> 6 out of 10 in the abbreviated mental test, and * are able to follow instructions and give informed consent. exclusion criteria: * • have any additional medical, cardiovascular or orthopedic condition * use a cardiac pacemaker * have receptive dysphasia * have a significant upper limb peripheral neuropathy * are involved in drug studies or other clinical trials, or * have severe shoulder, elbow, wrist or finger contractures that would preclude a passive range of motions of the arm, and * have a skin allergy that would prevent electrical stimulation.

Keywords: upper limb transcutaneous electrical nerve stimulation
evaluation of post hospital administration of celecoxib following minimally invasive knee replacement surgery

Conditions: Pain Management; Function; Minimally Invasive Total Knee Arthroplasty; Celecoxib

Summary: this study will evaluate the benefits of continuing celecoxib through six weeks of total knee arthroplasty recovery. this is a randomized, double blind study with a group of approximately 130 primary total knee patients. all patients will receive celecoxib throughout their hospitalization as per current minimally invasive total knee arthroplasty protocol. at the time of hospital discharge, participating patients will be randomly placed on either celecoxib 200mg twice a day or a placebo twice a day. this study will determine if the continued use of celecoxib for six weeks after total knee arthroplasty hospitalization will further decrease narcotic consumption, improve knee range of motion, improve ambulatory ability, and improve patient satisfaction over patients receiving celecoxib only during the acute hospitalization.


Eligibility criteria:
inclusion criteria: * having undergone a minimally invasive total knee by select surgeon * voluntarily enrolled * independent community ambulators * only patients being discharged directly home exclusion criteria: * celecoxib allergy or intolerence * renal insufficiency (defined as serum creatine level \>1.5 mg/dl or bun level \>22mg/dl * history of bleeding gastic or duodenal ulceration * new york heart association class iii or iv congestive heart failure * previous myocardial infarction or cerebralvascular event * severe inflammatory bowel disease * known coagulation abnormality or hepatic disease * chronic coumadin administration * refusal by primary or cardiac physician
dna mutation detection in circulating tumor dna and tissue by mmadps for pancreatic cancer

Conditions: Pancreatic Cancer

Summary: based on the cell free nucleic acid analysis information of blood samples and genetic mutation profile of eus-fnb tissue from pancreatic cancer, the concordance between them is evaluated. and based on this information, biomarkers for diagnosis, treatment, and prognosis of pancreatic cancer are explored.


Eligibility criteria:
inclusion criteria: * patients diagnosed with pancreatic cancer through histological or radiologic examination and before treatment begins * patients aged 18 or older who voluntarily agrees to participate in the study and is willing to understand and comply with the subsequent treatment procedures and sample collection schedule * among patients diagnosed with benign pancreatic diseases (pancreatic cyst, chronic pancreatitis, etc.), patients who have need for histological examination as control group exclusion criteria: * where the subject himself/herself refuses to fill out the consent form or is unable to fill out the consent form * if a laboratory test is impossible due to a qualitative problem with the collected blood sample * where the collected tissue does not contain tissue of the desired malignant or benign disease

Keywords: pancreatic cancer circulating tumor dna dna mutation dna methylation
neuroplasticity in parkinson´s disease after training

Conditions: Parkinson Disease; Physical Activity; Gait Disorders, Neurologic; Neural Degeneration

Summary: this project aims to determine the effects of the hibalance program on neuroplastic changes in people with mild to moderate parkinson´s disease. the main hypothesis is that highly challenging exercise will lead to greater gait and balance ability, increased levels of physical activity and an improved health related quality of life. the investigators further hypothesize that neuroplasticity changes will be seen in corresponding areas of the brain, neuropsychological changes on cognitive test measures, and that exercise will inhibit the degeneration of dopaminergic neurons in the brain through the mediation of neurotrophic factors.

parkinson's disease (pd) is a neurodegenerative disease affecting many physiological systems essential for balance control. new findings suggest that intensive, challenging and cognitively demanding exercises could induce neuroplasticity in pd. a new balance training (the hibalance program) have therefore been developed; emphasizing critical aspects of balance control through highly challenging and progressive exercises incorporating dual/multi-tasking (conradsson et al, 2012). in an rct, the hibalance-program was shown to improve balance, gait and physical activity level in favor for the training group (conradsson et al, 2015). in this proposal the investigators will combine physiotherapy, neurology and neuroimaging to characterise and determine the effects on physical and cognitive symptoms as well as structural and functional changes and wet biomarkers in the brain after the training. participants will be recruited through karolinska university hospital and via announcements in relevant forums like for instance the swedish parkinson association. according to earlier power calculations for detecting effects in balance and gait measures after this particular intervention, the investigators anticipate 40 to 50 participants in each group to detect significant changes. the investigators will perform both per protocol analysis and intention to treat analysis using mixed model or repeated measurement anovas if the data is normally distributed.

Eligibility criteria:
inclusion criteria: * diagnosis of idiopathic parkinson´s disease * hoehn \& yahr 2-3 * ≥ 60 years of age * be able to ambulate indoors without mobility aid * balance impairment exclusion criteria: * =\< 21 points on moca * other medical conditions that could substantially influence balance performance, voice or speech performance or participation in the interventions * participating in an intensive exercise program for balance or speech during the last six months. additional exclusion criteria for the brain imaging will include the presence of; pacemakers, deep brain stimulators or other mri incompatible implants, claustrophobia, inability to hear instructions without hearing aid, unilateral or bilateral blindness, severe diplopia, tremor, dyskinesia or dystonia.

Keywords: balance control exercise magnetic resonance imaging functional magnetic resonance imaging
the use of a ipom mesh for prevention of parastomal hernia

Conditions: Parastomal Hernia

Summary: study is a prospective, multicenter, randomized trial evaluating whether prophylactic laparoscopic placement of a dual-component ipom mesh around a colostomy may prevent parastomal hernia compared with conventional colostomy after abdominoperineal resection. eligible subjects will be recruited prospectively from five finnish hospitals (oulu university hospital,vaasa central hospital, helsinki university hospital, lahti central hospital, jyväskylä central hospital). patients were considered eligible for this study if undergoing laparoscopic abdominoperineal resection for rectal adenocarcinoma. patients are randomized to prophylactic preperitoneal placement of a dual-component mesh (dynamesh ipom) around permanent colostomy or to conventional permanent colostomy. estimating a parastomal hernia rate of 50%, a sample size of 26 patients per each study group is projected to provide 90% power (1-beta) with a alpha 0.05 (2-beta) to detect a 40% reduction in risk for parastomal hernia at 1-year. since we expect a dropout rate of 20%, 37 patients per study group will be included in this study. all abdominoperineal resections are performed using laparosopic technique. at the and of the abdominal laparoscopic phase the straight permanent end colostomy is performed. in the intervention group the 10 x 10 cm dynamesh ipom mesh is cut in the middle according to volume of the bowel. stapled bowel end is then pulled through the crosswise opened mesh, which is pushed to the abdomen and fixed to the peritoneum. follow-up visits are scheduled at 1-, 3- and 12-month after surgery. patients are evaluated for their clinical status and c-reactive protein, leukocytes and hemoglobin are assessed at each control visit. computed tomography (ct) scan with and without valsalva maneuver is performed 12 months after surgery for radiological evaluation of possible parastomal hernia. the primary end-point of this study is the incidence of clinically and radiologically detected parastomal hernias, and their extent 12 months after surgery. the secondary outcome end-points were colostomy-related morbidity such as stomal stenosis, necrosis and/or wound infection.the extent of parastomal hernia was graded at ct according to the hernia society criteria. statistical analysis is performed using a spss statistical software. continuous variables are reported as the mean and standard deviation, whereas nominal variables are reported as counts and proportions. univariate analysis is performed with the mann-whitney u test and fisher's exact test. p-values \< 0.05 are considered statistically significant.


Eligibility criteria:
inclusion criteria: * patients undergoing laparoscopic abdominoperineal resection for rectal adenocarsinoma exclusion criteria: * patients who can not give their consent to participate in the study * patients in poor general conditions (american society of anaesthesiologists classes 4-5) * patients with incurable cancer or another rectal malignancy than adenocarcinoma * patients with any abdominal infection

Keywords: prevention
adenovirus initiative study in epidemiology in uk

Conditions: Viral Conjunctivitis

Summary: the objectives of this study is to assess the characteristics and frequency of adenovirus conjunctivitis in a population of male and female patients from one year of age who present signs and symptoms of acute conjunctivitis.

epidemiological, prospective, open, multicentric trial in patients suffering from acute conjunctivitis who will undergo a rapid diagnostic test for adenoviral conjunctivitis at the time of their visit to the ophthalmologist office, at the emergency room or during hospitalization. this epidemiological study will include approximately 500 patients in the united kingdom. the planned duration of the study is one year from the first patient visit to the last patient visit.

Eligibility criteria:
inclusion criteria: * male or female patients of at least one year of age presenting acute (for less than 7 days) conjunctivitis signs and symptoms. * patient or / and legal representative (if patient below 18 years of age) must be able to provide oral consent for the collection and treatment of the questionnaire data. * no history of hypersensitivity to corn starch, talcum powder or dacron (sampling fleece components). exclusion criteria: * current use or having received (within the last 7 days) local antiviral therapies such as povidone iodine or ganciclovir, or topical steroids or immunomodulators such as cyclosporine which may interfere with the test result. * previous enrolment in the present study. * any direct involvement with the study conduct at site or any family link with study site staff.

Keywords: adenoviral conjunctivitis diagnosed with adenoplus™ test
concurrent school attendance and cancer therapy: the experiences of 6-12 year old pediatric oncology patients

Conditions: Leukemia; Lymphoma; Solid Tumor

Summary: many children with cancer cannot participate regularly in school due to frequent hospitalizations for treatment or treatment related effects such as pain, nausea, and fatigue. prior studies have shown that children with cancer desire to attend school while receiving therapy despite these challenges, and that they report psychological and psychosocial difficulties if unable to attend. while school attendance has been found to correlate with health-related quality of life (hrqol), self-efficacy beliefs, and self-esteem, little is known about how children with cancer experience school attendance while receiving active cancer therapy. the purpose of this study will be to explore how 6-12 year old children with cancer perceive school attendance pre and post diagnosis during active therapy as measured at one-time point, 6 months (± 2months) into active therapy.

the primary objective of this study is to explore 6-12 year old pediatric oncology patients' perceptions of their school experiences pre and post cancer diagnosis. this study will utilize qualitative interview methods. potential participants who meet inclusion criteria will be approached by the principal investigator to obtain consent and assent in accordance with institutional guidelines. upon giving consent, the child will participate in a one-hour audio-taped interview session with the principal investigator. the interview session will begin with some general rapport building questions to help the child grow comfortable with the interviewer, the interview room, and the interview format. the rest of the interview will consist of questions pertaining to the child's school experiences both before and during diagnosis and treatment for malignancy. the interview will conclude with the child being asked to draw a picture of themselves at school before diagnosis, and of themselves at school since being diagnosed. demographic data will be collected from each participant's medical chart pertaining to age, gender, ethnicity, diagnosis, and the type of school attended before and after diagnosis and the principal investigator and study staff involved in data coding will complete field note entries directly following the conclusion of each interview or data coding session (see appendix v). the participant's involvement in the study will end at the conclusion of the interview session.

Eligibility criteria:
inclusion criteria: * participant is 6-12 years of age at the time of diagnosis. * participant has a primary diagnosis of leukemia/lymphoma or solid tumor. * participant has been on therapy for six months (plus or minus 2 months) at the time of enrollment on this protocol. * participant is able to read and speak english. exclusion criteria: * participant has not received any type of schooling services either in the home, community, or hospital setting since diagnosis. * participant did not receive any type of schooling services prior to diagnosis.

Keywords: cancer therapy school attendance cancer diagnosis perception
development and polit study of get ready with my heart program

Conditions: Transition to Adult Care; Congenital Heart Disease

Summary: the goal of this clinical trial is to learn if the get ready with my heart program developed based on smart theory is applicable for ayas with chd to enhance their transition readiness. the main questions it aims to answer are: 1. is the get ready with my heart program clinically feasible？ 2. does the get ready with my heart program improve participants' transition readiness? participants will: 1. the intervention group will receive interventions according to the get ready with my heart program, while the control group will receive standard interventions. 2. outcome measures will be collected before the implementation of the program, and at 3 months and 6 months after the implementation.

china currently has the highest number of congenital heart disease (chd) patients in the world, placing a heavy disease burden on the country. as the number of adolescent chd patients continues to grow, the strain on pediatric healthcare systems increases significantly, which in turn imposes a serious disease burden on families and society. over the past thirty years, the overall health of children and adolescents in china has greatly improved, but they are now facing new health issues and societal challenges. for example, unhealthy lifestyle behaviors are prevalent, and mental health issues are on the rise. additionally, as treatment levels have improved, the focus of congenital heart disease care has shifted from simply improving survival rates to enhancing management throughout the entire lifecycle and overall prognosis. effective transitional care management not only helps improve patients' self-management abilities and adherence to treatment but also reduces the socio-economic burden and enhances patients' quality of life. however, studies show that only a minority of adolescent chd patients successfully complete this transition, highlighting the urgent need to strengthen transitional care management. the purpose of this clinical pilot trial is to verify the feasibility and effectiveness of a management program designed to improve the transition readiness of adolescents with congenital heart disease based on the smart model.

Eligibility criteria:
inclusion criteria: 1. age between 12 and 21 years; 2. diagnosed with congenital structural heart disease for at least 6 months; 3. regularly receiving outpatient follow-up at fudan university children's hospital; 4. cognitive abilities corresponding to age, with adequate reading and comprehension skills; 5. informed consent provided. exclusion criteria: 1. patients with physical conditions that limit participation (e.g., severe heart failure); 2. presence of other congenital malformations (e.g., various syndromes caused by chromosomal abnormalities); 3. patients with psychiatric disorders such as schizophrenia, intellectual disabilities, visual impairments, or other conditions that preclude participation in the study.

Keywords: transition to adult care chd adolescent
segmental and general stabilization exercises in chronic low back pain

Conditions: Segmental Stabilization; Generalized Segmental Stabilization Exercises

Summary: chronic low back pain effects more than 50% of general population. it's prevalence is higher is young adults that are economically active adults. its significance is often underestimated because usually young adults ignore these initial episodes of low back pain due to their busy life style or life full of commitments. approximately 70% of adults have at least one episode of low back pain during their lifetimes.

it will be randomized control trial with 60 patients with chronic low back pain divided into 2 groups. one group will be given segmental stabilization whose purpose is to achieve segmental control over primary stabilizers. second group will be given just generalized lumber stabilization exercises as it includes close chain exercises with low velocity as well as low load. this study will be conducted in rehabilitation setup of benazir bhutto hospital rawalpindi and iirs that is rehabilitation dept. at al nafees medical college and hospital, islamabad. non probability convenience sampling technique will be utilized

Eligibility criteria:
inclusion criteria: * both males and females will be included in the study exclusion criteria: * age limits of subjects will be between 15 to 60
gpc3-targeted car-t cell for treating gpc3 positive advanced hcc

Conditions: Hepatocellular Carcinoma

Summary: patients with hepatocellular carcinoma (a type of primary liver cancers) are enrolls in this study. the cancer has progressed after standard treatment, or the patient cannot receive regular treatment. investigator made a gene called chimeric antigen receptor derived from an antibody that recognizes glypican 3, a protein detected in in a large proportion of hepatocellular carcinoma. the gene will introduce into t cell from patient's blood to make them recognize and kill cancer cells. the aim of this study is to evaluate the efficacy, tolerance and safety of chimeric antigen receptor-modified t (car-t) cell targeting glypican 3 for advanced hepatocellular carcinoma.


Eligibility criteria:
inclusion criteria: 1. gpc3 positive hcc, tumor size \>= 5 cm, cannot receive standard treatment, expected survival time\>=3 months. 2. routine blood test: white blood cell count（wbc)\>= 2.5×10\^9/l, hemoglobin (hb)\>= 9.0 g/dl, blood platelet \>= 60×10\^9/l, lymphocyte percentage\>=15%. 3. blood biochemical parameters: alb \>= 30 g/l, alt \<= 5 times of the normal value, ast \<= 5 times of the normal value, serum lipase\<=1.5 times of the normal value, serum amylase\<=1.5 times of the normal value， total bilirubin \<= 2.5 times of the normal value. 4. prothrombin time inr \< 1.7. 5. ejection fraction (ef) \>= 55%, oxygen saturation (so2) \> 90%. 6. no allergic reaction to contrast material. 7. karnofsky score \>= 60%. 8. child-puge score \<7. 9. peripheral venous access. 10. voluntarily signed informed consent. exclusion criteria: 1. pregnancy or lactation. 2. systemic steroid treatment ( \>prednisone equivalent/kg/day). 3. patients with previous history of cell immunotherapy or antibody therapy. 4. patients received radiotherapy/chemotherapy in the past 4 weeks. 5. patients are participating in other clinical trials. 6. patients with uncontrolled symptoms including infection, heart failure, arrhythmia. 7. patients with acute allergic reaction. 8. history of liver transplantation. 9. patients with anticoagulant treatment. 10. patients with hepatic encephalopathy. 11. eligible for hepatectomy, liver transplantation or other standard treatment. 12. unstable gastrointestinal and respiratory bleeding. 13. active viral, fungal or bacterial infections. 14. heart failure classification (nyha): ii-iv. 15. patients are unable or unwilling to comply with the requirements of the study protocol. 16. patients do not meet the criteria above.

Keywords: chimeric antigen receptor t cell (car- t) glypican-3 (gpc3) hepatocellular carcinoma (hcc)