Kornimate/medical-research-clean huggingface dataset:
triple h odc trial

Conditions: Hypoxia; Hypothermia, Accidental; Hypercapnia; Avalanche, Landslide, or Mudslide

Summary: in an avalanche burial with an air pocket hypercapnia (and hypoxia) develops within few minutes, hypercapnia increases the rate of cooling and therefore the development of hypothermia. the triple h syndrome (hypoxia, hypercapnia, hypothermia) occurs. this specific combination of the three parameters is unique for avalanche burial with an air pocket. every single parameter has a substantial effect on the hemoglobin-oxygen dissociation curve, but until now no study described the combination of these three parameters. this curve will be measured under these specific conditions in a specifically developed in vitro model, to quantify its shifts and to show if there are combined effects of pco2 and temperature. the newly developed method will be validated in comparison with an established method. the project will be performed with whole blood, drawn by healthy volunteers, in an experimental setting. the samples will be blinded to the investigator and analyzed in a randomized manner.

the odc is a function of po2 and so2. po2, the independent variable, is plotted on the x axis, so2 on the y axis. for the determination of this function, a pairwise measurement of po2 and the corresponding so2 is to be performed. using nonlinear regression analysis, the odc can be fitted to the measured points that describe the relation of po2 and so2 and characteristic parameters like p50 value and inflection points can be calculated. to measure the odc under the conditions of the triple h syndrome (hypoxie, hypercapnia, hypothermia), the temperature and the pco2 have to be changed and controlled during the measurement. no commercially available instrument is able to obtain this. therefore, we envisaged the development of an entirely new approach. in the 3h odc trial venous blood will be drawn from 18 - 40 years old female and male volunteers by a unique venipuncture. the participants have to be in a fasted situation, asa i and nonsmokers. the blood sample will be immediately pseudonymized and stored on ice and a venous blood gas analysis will be carried out (ph, hb, cohb, methb, fhb). simultaneous to the main measurement, 2,3 bpg will be quantified by an elisa test and any unknown hemoglobinopathy will be excluded by hemoglobin electrophoresis. in the 3h odc trial 4 different pco2 levels and 4 different temperatures will be analyzed in the resulting 16 combinations. in each round a lot of odcs will be measured, the measurement chamber will be filled with participants blood samples in a randomized manner. after the measurements, the blood samples will be discarded.

Eligibility criteria:
inclusion criteria: * 18-40 years * fasted situation * asa i * informed consent exclusion criteria: * any drug abuse * any drug intake within the last 10 days * smoking * known hemoglobinopathy * relevant illness within last 14 days * relevant blood loss within last 14 days * pregnancy or breast-feeding * participation in any pharmacological study * exposure to high altitude (\> 3000 m) within last 4 weeks
dry needling versus conventional physical therapy in patients with knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: the purpose of this research is to compare the effectiveness of conventional physical therapy (manual physical therapy, exercise, range of motion, and stretching) versus conventional physical therapy combined with dry needling in patients with knee osteoarthritis (oa). physical therapists commonly use conventional physical therapy techniques and dry needling to treat knee oa, and this study is attempting to find out if the addition of dry needling to conventional physical therapy has an equal, greater, or lesser effect than conventional physical therapy alone.

patients with knee oa will be randomized to receive 1-2 treatments per week for 6 weeks (up to 10 sessions total) of either: (1) dry needling and conventional physical therapy or the (2) conventional physical therapy (manual physical therapy, exercise, range of motion and stretching)

Eligibility criteria:
inclusion criteria: 1. report of knee pain of at least 2/10 per nprs (0---10 scale) for \>3 months 2. report of at least 3 of the following per altman et al. (1986) * over 50 years of age * less than 30 minutes of morning stiffness * crepitus on active motion * bony tenderness * bony enlargement * no palpable warmth of synovium exclusion criteria: 1. report of red flags to manual physical therapy to include: hypertension, infection, diabetes, peripheral neuropathy, heart disease, stroke, chronic ischemia, edema, severe varicosities, tumor, metabolic disease, prolonged steroid use, fracture, ra, osteoporosis, severe vascular disease, malignancy, etc. 2. history of previous surgery to the knee 3. history of physical therapy, massage therapy, chiropractic treatment, or injections for knee pain in the last 4 weeks 4. history of a surgical procedure on either lower extremity in last 6 months 5. two or more positive neurologic signs consistent with nerve root compression, including any two of the following: * weakness involving a major muscle group of the lower extremity. * diminished patella or achilles tendon reflex * diminished or absent sensation to pinprick in lower extremity dermatome 6. involvement in litigation or worker's compensation regarding knee pain. 7. any condition that might contraindicate the use of electro-needling 8. the patient is pregnant.
implementation of an empiric transfusion bundle for out of hospital patients with haemorrhagic shock

Conditions: Haemorrhagic Shock; Trauma Coagulopathy

Summary: the investigators will evaluate the implementation of a treatment bundle (fibrinogen, plasma and tranexamic acid)

the investigators will perform a prospective observational study of patients in haemorrhagic shock with suspected life threatening bleeding from trauma, treated by the prehospital emergency doctor response team of the medical university of graz and the hems (helicopter emergency medical service) of graz according to their sops. only patients that are being transported to the resuscitation room of the medical university of graz after prehospital transfusion will be included. the sops for prehospital transfusion are being implemented for the treatment of patients in extremis because of suspected life-threatening traumatic bleeding in the above-mentioned emergency services, according to the manufacturer's requirements. these transfusion sops are already part of the standard of care in the resuscitation room of the medical university of graz. this study seeks to gather information on the benefits and potential harms of this change of prehospital clinical routine. the treatment bundle will include 2 units of fibrinogen and plasma in addition to 10-20 mg/kg tranexamic acid

Eligibility criteria:
inclusion criteria: * aged, or believed to be aged * 18 years or above * confirmed or suspected life-threatening bleeding from trauma (i.e. signs of inadequate perfusion of tissues, tachycardia, hypotension, suspected blood loss) * need for volume replacement therapy. exclusion criteria: * patient with known recent history of thromboembolic events within the last 6 months * known or suspected pregnancy at presentation * patient with known refusal of a participation in this clinical trial.

Keywords: trauma coagulopathy haemmorhage transfusion
robotics for rehabilitation therapy: functional versus individual joint training

Conditions: Cerebrovascular Accident

Summary: the purpose of this study is to develop an upper extremity robotic training system for use by people with stroke to practice arm and hand movement in the clinic.

each year in the u.s. over 400,000 people survive a stroke and approximately 80% of acute stroke survivors lose arm and hand movement skills. movement impairments are typically treated with intensive, hands-on physical and occupational therapy for several weeks after the initial brain injury. unfortunately, due to economic pressure on the u.s. health care system, stroke patients are receiving less therapy and going home sooner. our goal for this study is to develop an upper extremity robotic training system for both acute and chronic stroke population to improve movement ability with intensive and repetitive movement in the clinic without continuous supervision from a therapist.

Eligibility criteria:
inclusion criteria: * age between 18 and 73 * sustained single stroke at least three months previously * minimal to moderate lost motor control of the arm after stroke exclusion criteria: * concurrent severe medical problems * severe cognitive dysfunction * severe neglect or apraxia * severe visual deficits * significant subluxation of the shoulder * presence of severe elbow or wrist contracture * any metal implants or surgical clips or mechanical devices * metallic hardware on scalp region * prior diagnosis of seizure and epilepsy * severe migraine headache * currently pregnant or lactating * claustrophobic * currently taking medication that lower seizure threshold

Keywords: stroke cerebrovascular accident robot
nutritional deficiencies about recurrent miscarriage

Conditions: Abortion, Habitual; Nutritional Status

Summary: the study plans to recruit patients with recurrent miscarriage and detect their niacin, thiamine, vitamin a, vitamin b6, vitamin b12, vitamin d levels in plasma, evaluating if some lack exists.

dr. shi hongjun from west lake university has confirmed in a mouse model that a decrease in maternal niacin levels caused by a low niacin diet can lead to stillbirth(hj shi, et al. 2017). due to the lack of a recognized clinical niacin test, it is unclear whether niacin deficiency is associated with abortion. however, some studies have showed: 1. nearly one-third of pregnant women present low niacin level during the first trimester of pregnancy; 2. insufficient parent niacin intake is positively correlated with the incidence of congenital heart disease; 3. vitamin b6 affects niacin metabolism, while maternal b6 deficiency is significantly associated with early abortion. based on this, the investigators predict that (1) a certain proportion of recurrent abortion women's niacin levels are lower than the normal range of women's normal; (2) supplementation of niacin can reduce the risk of repeated abortion. there are many methods for detecting niacin, but so far with no reports for large population. dr. shi hongjun from west lake university used the most sensitive qtrap 6500+ liquid chromatography tandem mass spectrometer to accurately quantify the concentration of nad, nicotinamide, niacin and other niacin metabolites in plasma and have optimized the detection process, which would be applicated in this study. at the same time, studies have shown that pregnant women generally have multiple vitamin deficiency during pregnancy, including plasma thiamine, vitamin a, vitamin b6, vitamin b12 and vitamin d. therefore, in addition to detecting plasma niacin, this study will also examine the plasma levels of the remaining multivitamins to further explore the impact of nutritional deficiencies on the probability of recurrent miscarriage.

Eligibility criteria:
inclusion criteria: * research group 1: recurrent abortion group: women of childbearing age who have spontaneous abortion within 20 weeks of pregnancy for 2 or more consecutive times. control group: 1) women of childbearing age who had a normal pregnancy history and are not in pregnancy status now. 2) women of childbearing age in general examination. exclusion criteria: * patients with confirmed causes unrelated to nutritional deficiencies, including 1. both husband and wife have been diagnosed with chromosomal abnormalities or fetal chorionic chromosomal abnormalities; 2. the patient has been diagnosed with uterine abnormalities; 3. vaginal bacterial infection or chlamydial infection; 4. antiphospholipid antibody syndrome; 5. other immune system diseases (hypothyroidism, pcos, hyperprolactinemia); 6. ovarian function decline (fsh\>10miu/ml); 7. cervical insufficiency5.3 exit criteria: after being selected, the researcher was withdrawn due to various considerations.

Keywords: recurrent miscarriage vitamins
how does 4 weeks of increased fast food intake affect metabolism?

Conditions: Hyper-Alimentation; Healthy

Summary: objective: to study the effect of fast food-based hyper-alimentation on liver enzymes and hepatic triglyceride content (htgc)and metabolism. design: prospective interventional study with parallel control group. setting university hospital of linköping, sweden. participants: 12 healthy men and six healthy women with a mean (sd) age of 26 (6.6) years and a matched control group. intervention: subjects in the intervention group aimed for a body weight increase of 5-15% by eating at least two fast food-based meals a day with the goal to double the regular caloric intake in combination with adoption of a sedentary lifestyle for four weeks. main outcome measures: weekly changes of serum aminotransferases and htgc measured by proton nuclear magnetic resonance-spectroscopy at baseline and after the intervention.


Eligibility criteria:
inclusion criteria: * healthy non-obese subjects exclusion criteria: * general diseases, obesity.

Keywords: weight metabolism cholesterol insulin
relationship of genes and life events to blood pressure

Conditions: Hypertension; Psychosocial Factors

Summary: research suggests that blood pressure is influenced by both genetic and environmental factors. the goal of this study is to find genes that play a role in blood pressure and understand how they interact with life events (such as job stress) to influence blood pressure. we hypothesize that the gene for endothelin-1 is associated with increased blood pressure. further, we predict that this genetic relationship is moderated by psychosocial stress factors, specifically job strain and marital cohesion.


Eligibility criteria:
inclusion criteria: * previous participation in a study of psychosocial stressors and blood pressure (double exposure study) and agreement to participate in follow-up studies exclusion criteria: * withdrawal of consent

Keywords: hypertension blood pressure psychosocial factors
triamcinolone vs. laser for diabetic macular edema

Conditions: DIABETIC MACULAR EDEMA

Summary: the purpose of this study is to determine if intravitreal triamcinolone acetonide (ivta) injection at the time of cataract surgery will improve visual acuity and decrease post-operative swelling in diabetic patients requiring cataract extraction as compared to the conventional treatment of laser following cataract surgery. the subjects will be followed for 11 visits over 3 year. visits will occur at screening,1, 3,6,9,12,18,24,30 and 36 months post surgery.

protocol summary: this is a randomized, prospective study comparing diabetic patients with pre-operative macular edema undergoing cataract surgery treated with either 4 mg of intravitreal triamcinolone at the time of cataract surgery or focal laser treatment 1 month following cataract surgery. disease state: the conventional treatment for clinically significant macular edema is focal laser photocoagulation. in some diabetic patients however, the cataract often impedes fundus visualization for optimal laser treatment. in these patients focal laser treatment is deferred until after cataract surgery. study aim: the purpose of this study is to determine if intravitreal triamcinolone acetonide (ivta) injection at the time of cataract surgery will improve visual acuity and decrease post-operative macular edema in diabetic patients with pre-operative macular edema requiring cataract extraction as compared to the conventional treatment of focal laser photocoagulation following cataract surgery. hypothesis: we propose that by injecting triamcinolone intravitreally at the time of cataract surgery in patients who have pre-operative macular edema, we will not only reduce the risk of exacerbating macular edema but also possibly improve the final visual outcome. study procedures: after informed consent is obtained each patient will be placed, based on a randomization scheme, into either the control group receiving the conventional focal laser treatment one month following cataract extraction or into the study group receiving the ivta injection at the time of surgery.

Eligibility criteria:
inclusion criteria: * visually significant cataracts * pre-operative visual acuity 20/50 or worse * pre-operative optical coherence tomography (oct) showing at least 250 microns central foveal thickness. exclusion criteria: * macular ischemia * vitreomacular traction * macular hole

Keywords: cataract extraction macular edema diabetes focal laser triamcinolone
percutaneous ethanol alcohol injection for the large and unresectable hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma Non-resectable

Summary: assessment of the long-term outcome of percutaneous ethanol alcohol injection (pei) for the large and unresectable hepatocellular carcinoma: single center non-randomized trial.

assessment of the overall (os); one year; two years and three years' survival rates; the disease free survival (dfs) and the tumor response rate in the patients undergoing (pat or pei) for the large and inoperable hepatocellular carcinoma. this is a prospective non randomized trial carried out at the ribat university hospital between may 2017 to april 2020.

Eligibility criteria:
inclusion criteria: * review and sign informed consent; * between 15 and 80 years of age at time of trial enrollment; * documented pathological and/or radiological diagnosis of hepatocellular carcinoma; * radiologically documented tumor size of \> 5 centimeters; * radiologically documented liver cirrhosis. exclusion criteria: * american anesthesia association (asa) class iv or v and/or any * contraindications to general anesthesia; * uncontrollable ascites; * deep persistent jaundice; * hepatic encephalopathy; * coagulopathy; * severe thrombocytopenia; * unable or unwilling to attend follow up visits and examinations; * other associated surgical procedure;

Keywords: percutaneuos ethanol alcohol injection
effects of immune checkpoint inhibitors on coronary microvasculature

Conditions: Coronary Microvascular Dysfunction; Cardiotoxicity; Breast Cancer; Lung Cancer (NSCLC)

Summary: this is an observational study that includes patients with breast cancer or non-small cell lung cancer who will be treated with immune checkpoint inhibitor (ici) therapy. the investigators will use echocardiograms, blood draws, and pet stress tests to understand how ici therapy affects the heart and circulatory system.


Eligibility criteria:
inclusion criteria: * ≥18 years of age * either diagnosis of breast cancer with plan for treatment according to the keynote 522 regimen or non-small-cell lung cancer planned for neoadjuvant treatment that includes pembrolizumab * able to provide written informed consent exclusion criteria: * pregnant or breast-feeding: * prior treatment with ici therapy. * vulnerable patients, including pregnant women and prisoners * absolute contraindication to rest/vasodilator stress pet/ct

Keywords: cancer therapy related cardiotoxicity immune checkpoint inhibitor therapy
interactive cholesterol advisory tool

Conditions: Low Risk (0-10% Chance) of Developing Cardiovascular Disease Within 10 Years Based on Risk Factors; Moderate Risk (10-20% Chance) of Developing Cardiovascular (Heart) Disease Within 10 Years Based on Risk Factors

Summary: the purpose of this study is to show that we can effectively deliver health information and education, online, via computer regarding cholesterol. this computer program is called the interactive cholesterol advisory tool (icat).

participants will be recruited and categorized based on screening labs into 1 of 2 groups: low or moderate risk of developing cardiovascular disease within 10 years based on risk factors. the low risk group will be advised to take the blood test results furnished by the study to their primary care doctor to discuss managing cholesterol. the moderate risk group will see the study physician for 4 visits about high cholesterol. both groups complete a total of 4 blood draws over 9 months. both groups will be randomized at consent into 2 groups: 1 who uses the interactive cholesterol advisory tool (icat) and 1 that does not use the icat. because recruitment goals for the low risk group were met, a third group was created: low risk who both the study physician for 4 visits about high cholesterol and use the icat.

Eligibility criteria:
inclusion criteria: * fluency in english, * willing to come in for 1-5 visits, * low and moderate cvd risk. * having access to a computer with internet connection exclusion criteria: * cvd diagnosis or cvd equivalent, * psychosis, terminal illness, * pregnancy, * current statin use if assigned to the low risk group * liver disease, * peripheral vascular disease, * diabetes mellitus, * abdominal aortic aneurism, * cerebral vascular disease * triglyceride level above 500 mg/dl * uncorrected hypothyroidism

Keywords: cardiovascular disease cholesterol
open-label, long-term balsalziade disodium tablet ulcerative colitis study

Conditions: Inflammatory Bowel Disease; Ulcerative Colitis

Summary: the objective of the study is to evaluate the long-term safety and tolerability of treatment with balsalazide disodium tablets in subjects who are in remission from ulcerative colitis or who have mildly to moderately active uc.

the objective of the study is to evaluate the long-term safety and tolerability of treatment with balsalazide disodium tablets in subjects who are in remission from ulcerative colitis or who have mildly to moderately active uc.

Eligibility criteria:
inclusion criteria: * subject has a documented history of uc and is either in remission or currently presents with mildly to moderately active uc symptoms as determined by the investigator upon subject interview of uc symptoms, (e.g., urgency, bowel frequency, and rectal bleeding). additionally, the diagnosis of uc must be confirmed by past flexible sigmoidoscopy/colonoscopy which may include colonic mucosal pathological findings on biopsy consistent with uc. * subject is capable and willing to comply with all study procedures. exclusion criteria: * subject has a history of allergy or intolerance to aspirin, mesalamine or other salicylates. * subject has participated in an investigational drug or device study, other than a previous balsalazide disodium tablet trial (i.e., bzuc3002 or bzuc3003), within 30 days of entering the current study. * subject discontinued from a previous balsalazide disodium tablet study due to study drug-related ae(s), including uc flare or associated symptoms that were perceived by the subject/investigator as being caused by study drug. * subject has had any prior bowel surgery, except appendectomy and cholecystectomy. * subject has unstable cardiovascular, coagulopathy, or pulmonary disease. * regular use of nonsteroidal anti-inflammatory drugs (nsaids) except cardioprotective asa (i.e., less than or equal to 162 mg asa per day). * subject has a history of human immunodeficiency virus (hiv) or hepatitis (b and c). subjects with a history of hepatitis b and c will be eligible provided the screening lfts are within normal limits.

Keywords: ibd uc ulcerative colitis inflammatory bowel disease