Kornimate/medical-research-clean huggingface dataset:
retrospective study on the evaluation of intra-disc infiltration in the active disc disease

Conditions: Disc Disease

Summary: active discopathies or modic 1, are a diagnostic entity discovery with the contribution of mri in which the first cases were described by dr. michael modic in 1988. it is characterized by a vertebral bone edema secondary to active discarthrose. its prevalence is estimated at 6% of the general population and up to 40% of the clbp according to studies. following the discovery of this recent diagnostic entity, responsible for low back pain, the question of its management is debate in the medical community. early studies demonstrate the effectiveness of corticosteroid injections in intra-disc. other works, most recent, suggest the contrary, infectious, incriminating a pathogenic role of certain bacteria such as propionibacterium acness or corynebacterium propinquum recommending, in contrast, treatment with prolonged antibiotic therapy. this study will aim to assess the effectiveness of intra-disc infiltration ghpsj carried out between 2007 and 2014. the innovation of our work will be to assess these infiltrations in various subgroups such as patients with a previous surgery of the spine or a history of scoliosis or spondylolisthesis.

1. primary objective: evaluate the effectiveness of intra-disc infiltrations conducted in the rheumatology department of pain in the active disc disease. 2. secondary objectives: * evaluate the duration of the benefit on pain caused by gesture * assess the impact of the gesture on nsaids and / or analgesics * analysis of different subgroups (antecedent of surgery, spondylolisthesis, scoliosis) inclusion / non-inclusion: patients older than 18 who were hospitalized between 2007 and 2014 in the rheumatology department for intradiscal infiltration. methodology: a retrospective, single-center, non-interventional study duration: 6 months acquisition of data: demographic data, data on the disc disease, data on the assessment of pain, the effectiveness of infiltration of analgesics and / or nsaids, or need infiltration surgery for the gesture. supports: patient questionnaire report hospital, medical, excel grid of data collection), analysis (statistic: local management) anonymised data in the excel spreadsheet development of the study: data collection, statistical analysis, literature review retrospective study based on recovering data regarding efficacy of infiltrative gesture that some patient was performed in 2007, with possibility of bias on the recovery of data in view of the age of the gesture for some patients. an analysis of each folder from the hospital report will be carried out in parallel in order to compare the data collected by the questionnaire with the reporting. the sending of questionnaires and letters will be performed by the service attaches where a pre-stamped letter. the address of the patients will be that recorded in the base dxcare.

Eligibility criteria:
inclusion criteria: * patient aged \> 18yo * hospitalization between 2007 and 2014 in the rheumatology department for intradiscal infiltration exclusion criteria: * none
musculoskeletal problems and strategies developed by physiotherapists to cope with them

Conditions: Occupational Diseases; Muscle Pain

Summary: the aim of this study is to investigate whether there is a difference in areas such as occupational musculoskeletal injuries and strategies developed by physiotherapists working in different fields, burnout and occupational satisfaction.

this study is a descriptive, cross-sectional online survey study. in this study, it is aimed to reach people who have graduated from the physiotherapy and rehabilitation departments of the faculties of health sciences or the physical therapy and rehabilitation schools of universities in turkey, which provide education for 4 years and have the title of "physiotherapist". physiotherapists will be divided into 5 groups according to the fields they work. group 1 is only pediatric patients, group 2 is orthopedics and sportsman, group 3 is neurology and intensive care, group 4 is general group that receives patients in many fields, and group 5 is physiotherapists working in the field of public health. planned to occur. before starting the study, the participants will be asked to fill in the volunteer and consent form that they voluntarily participated in, and then they will be asked to fill out the personal information form, the extended nordic musculoskeletal system questionnaire, the pain coping inventory, the maslach burnout scale, and the vocational satisfaction scale prepared by us. according to the results obtained, 5 different groups will be compared among themselves by the determined parameters. the surveys to be used will be uploaded to the google forms database. then, the participants will be asked to participate in the study by being reached via online media such as e-mail, mobile phone applications , social media.

Eligibility criteria:
inclusion criteria: * volunteering to participate in the study * being a physiotherapist * having completed at least 1 year in the profession and continuing an active working life * being between the ages of 21 and 60 exclusion criteria: * not having completed 1 year in the profession * having any systemic disease

Keywords: physiotherapist burnout professional satisfaction
rapid hiv testing for emergency department patients

Conditions: HIV Infections

Summary: the purpose of this study is to test data collection options in emergency departments (eds) and to enhance ed patient awareness of the risk of hiv infection.

rapid hiv testing is a new technology that speeds receipt of hiv test results. its use in eds has been demonstrated, but patient acceptance of rapid testing in the ed has not been optimal. it is likely that the low acceptance is partially due to ed patients not realizing the risk of acquiring an hiv infection or the importance of knowing their hiv status. the purpose of this study is to test data collection options in eds and to enhance ed patient awareness of the risk for hiv infection. this three phase study will take place at the rhode island hospital emergency department. each participant will be followed for the duration of their ed visit. in phase i, the proportion of participants who are willing to undergo rapid hiv testing in the ed will be measured. additionally, the hiv testing history of these participants, their reasons for undergoing testing or for never having been tested for hiv, and factors associated with acceptance or decline of testing and history of hiv testing will be determined. an educational video will be developed and used to investigate its effectiveness in convincing participants to have the rapid hiv test. all participants agreeing to undergo a rapid hiv test will receive a survey to complete. in phase ii, a questionnaire and feedback tool to make participants aware of their risk for an hiv infection through injection drug use and sex will be developed and investigated. in phase iii, the questionnaire and feedback tool developed in phase ii will be used to determine whether or not making participants aware of their risk for an hiv infection increases their acceptance of being tested for hiv in the ed. participants in arm 1 will receive the questionnaire and feedback tool while participants in arm 2 will not.

Eligibility criteria:
inclusion criteria: * english-speaking * subcritical illness or injury exclusion criteria: * critical illness or injury * mental or physical disability * known hiv infection * participation in an hiv vaccine study * prison inmate * acute psychiatric illness that, in the opinion of the investigator, would prevent the participant from completing the study

Keywords: patient education emergency medicine hiv prevention hiv seronegativity
drug-coated balloon versus drug-eluting stent in the treatment of coronary artery lesions in stemi patients in de novo coronary lesions

Conditions: Acute Myocardial Infarction

Summary: the study aims to find a dcb treatment for stemi patients can achieve early and mid-term functional outcomes that are not inferior to des, and realize the strategy of intervention without implantation.

the main objective of this study is to compare a drug-coated ballon with drug-eluting stent in the treatment of coronary arty lesions in stemi patients in de novo coronary lesions.the study aims to find a dcb treatment for stemi patients can achieve early and mid-term functional outcomes that are not inferior to des, and realize the strategy of intervention without implantation.

Eligibility criteria:
inclusion criteria: 1. clinical criteria 1)over 18 years old 2)angiographic confirmation of acute myocardial infarction 3)ekg prompts stem basis 4)sign informed consent 2. angiographic criteria 1)in situ coronary artery disease 2)the reference diameter of the target vessel was 2.5-3.5 mm and the length was less than 28 mm 3)visual examination showed that the diameter of lesions in criminals was narrower than or equal to 80%. exclusion criteria: 1.clinical criteria 1. lvef\<30% 2. killip grading is greater than 3 3. significant abnormalities in hemorrhagic quality or known coagulation function 4. history of intracranial tumors, aneurysms, arteriovenous malformations or cerebral hemorrhage;there was a history of stroke or tia in 6 months and gastrointestinal bleeding in 2 months.major operations were performed within 6 weeks.recent or known platelets \< 100,000/mm3 or hemoglobin \< 10 g/dl. 5. planned elective surgery may lead to early discontinuation of adp receptor antagonists 6. the expected survival time of patients with other systemic diseases, such as malignant tumors is less than 1 year 2.angiographic criteria 1)left main lesion 2)the grade of dissection is greater than or equal to grade c lesions. 3)coronary artery bridge lesions 4)in-stent restenosis 5)severe stenosis of non-criminal lesions requiring selective treatment
evaluation of a digital school-based intervention for the primary prevention of eating disorders in pre-adolescents (preta program)

Conditions: Eating Disorders in Adolescence; Food Addiction

Summary: background: eating disorders (ed) are mental health conditions, characterized by pathological behaviors toward food intake or a persistent obsession with weight control. eds have a high prevalence among pre-adolescents in developed countries and pose a significant economic burden. preventive interventions targeting at-risk populations for ed have proven effective. the use of information and communication technologies (icts) facilitates access to larger population groups while also reducing costs. objectives: * develop and validate a universally applied intervention, mediated by icts, for the primary prevention of eating disorders (preta), through cultural adaptation and adjustment of the potsdam prevention at schools (pops) program to preadolescents. * assess the efficacy of the preta program through a randomized controlled trial (rct). * evaluate the efficiency of the preta program from a social perspective. methodology the preta program uses 9 online sessions with interactive activities for pre- adolescents, plus education for their families and teachers. its content includes addressing key factors in the development of ed, such as eating habits, beauty standards, and media literacy, as well as activities aimed at strengthening psychological dimensions (self-esteem, emotional regulation, problem-solving, psychological flexibility, and resilience) and social skills, including communication styles and distinguishing between jokes and bullying. the study involves schools being randomly assigned to either the preta program or regular health activities. the effect of the intervention will be evaluated 3 months after its start.

a matched-pair cluster random allocation will be used, with schools being asigned as clusters. five schools will be assigned to each group.

Eligibility criteria:
inclusion criteria: * enrolled in the fifth or sixth year of primary education. * informed consent provided by the student's legal guardians and responsible teacher to participate. exclusion criteria: * significant comprehension difficulties that limit adequate participation in the program and questionnaires.

Keywords: eating disorders school-based intervention efficacy efficiency primary prevention program
gricovax study in 4 maternity wards in the ile-de-france region

Conditions: Pertussis Vaccine; Healthcare Worker Patient Transmission; Pregnant Women; Influenza Vaccination

Summary: implementation of organizational adjustments can enhance involvement of healthcare teams in carrying out flu and pertussis vaccinations, and optimizing access to vaccines for women and their families. pertussis vaccination of pregnant women is envisaged by the french health autority, considering that, given international experiences, vaccination during the second trimester of pregnancy is safe, effective, and would aim to protect babies during the first months of their life. before considering such a recommendation in france, the acceptability of this strategy by pregnant women and health professionals must be considered.

multicentre, descriptive study conducted in a declarative manner and supplemented by direct observation by an investigator. main objectives: * assess existing practices of the various actors involved in flu and pertussis vaccination of pregnant or postpartum women medically followed in maternity wards. * assess acceptability of pertussis and flu vaccination during pregnancy by women medically followed in maternity wards, and by health professionals of theses facilities. secondary objectives: * assess flu and pertussis immunization coverage of pregnant and postpartum women and of health professionals working in maternity wards. * assess the links between immunization coverage of health professionals and their current practices in promoting flu and pertussis vaccination of women in maternity wards. main outcome measures: * identify in each maternity hospital facilitators of flu and pertussis vaccination. * proportion of women willing to be vaccinated against pertussis and flu during pregnancy. * proportion of health professionals agreeing to vaccinate pregnant women against flu and pertussis. secondary endpoints: * flu and pertussis immunization coverage of pregnant and postpartum women. * flu and pertussis immunization coverage of health professionals. * proportion of patient records with vaccination trace. * link between understanding of vaccines and vaccine-preventable diseases, and immunization coverage of health professionals. * link between attitudes and practices of health professionals, and immunization coverage of patients. * link between immunization coverage of patients and health professionals.

Eligibility criteria:
inclusion criteria: pregnant and postpartum women over 18 medically followed in maternity wards included. femmes enceintes ou en post-partum : health professionals over 18 working in maternity wards included. exclusion criteria: women under the protection of a conservator temporary health staff
a study in children with different formulations of gsk biologicals' 11 valent pneumococcal conjugate vaccine

Conditions: Streptococcal Infections

Summary: three dose primary vaccination with 11-valent pneumococcal conjugate vaccine administered concomitantly with infanrix™ hexa to healthy infants between 8 to 16 weeks of age at the time of first vaccination.

test groups: 9 groups receiving different formulations of 11pn-pd-dit vaccine + dtpa-hbv-ipv/hib (infanrix™ hexa) comparator: 11pn-pd + infanrix™ hexa control: prevenar® + infanrix™ hexa

Eligibility criteria:
inclusion criteria: * male or female aged 8-16 weeks at the time of first vaccination, written informed consent obtained from the parent/guardian of subject. exclusion criteria: * use of any investigational or non-registered drug or vaccine other than the study vaccine within 30 days preceeding the first dose of study vaccine, or planned use during the study period. * planned administration/ administration of a licensed vaccine not foreseen by the study protocol during the period starting from 30 days before the first dose of vaccine(s) and ending 30 days after the last dose.
the effect of using multimedia during the informed consent process on the anxiety of parents of orchiopexy patients

Conditions: Undescended Testis; Anxiety State

Summary: aim: the goal of this randomized controlled trial is to detect the effect of using multimedia during the informed consent process on the anxiety of parents of orchiopexy patients. parents (primary caregivers) of the patients who underwent orchiopexy surgery are included in the study. the main question it aims to answer is: • does the use of multimedia during the preoperative consent process affect the anxiety level of parents of patients undergoing orchiopexy surgery?

aim: the goal of this randomized controlled trial is to detect the effect of using multimedia during the informed consent process on the anxiety of parents of orchiopexy patients. parents (primary caregivers) of the patients who underwent orchiopexy surgery are included in the study. the patient's age, gender, known diseases, previous hospital admissions, and whether they have undergone surgery before will be recorded. the primary caregiver's age, gender, known diseases, educational status, occupation, number of children, and any additional illnesses in other children will be noted. patients will be randomized into 2 groups with the help of (https://www.randomizer.org/ ). the first group will be informed of the standard consent form and verbal information during the preoperative process. in contrast, the second group will be informed of the standard consent form, verbal information, and multimedia. both groups will fill out the hospital anxiety and depression scale(hads), beck anxiety inventory(bai), and the state-trait anxiety inventory (stai) form tx 1-2 forms one day before the surgery and on the 7th day after the surgery to determine their anxiety levels.

Eligibility criteria:
inclusion criteria: * parents of orchiopexy patients exclusion criteria: * history of previous orchiopexy surgery * orchiopexy with other surgical procedures ( f.e. hypospadias repair)

Keywords: undescended testis anxiety state
open-label pharmacokinetics (pk)/safety study of luliconazole solution, 10% in distal subungual onychomycosis

Conditions: Onychomycosis

Summary: to determine the safety, tolerability, systemic exposure and pharmacokinetics of luliconazole after repeat daily topical application of luliconazole solution, 10% in a maximal use setting in adults with distal subungual onychomycosis of the toenails.


Eligibility criteria:
inclusion criteria: * 18-65 years * distal subungual onychomycosis(dso)on both great toenails with \>=50%involvement of at least 1 great toenail * at least 4 additional toenails with dso * positive koh and culture * normal renal and hepatic function exclusion criteria: * subjects with hypersensitivity to imidazole compounds or any other ingredient * subjects unwilling to refrain from use of nail cosmetics until end of study * subjects with symptomatic tinea pedis * subjects with any history of cardiac disease of cardiac rhythm abnormalities * female subjects who are pregnant, nursing, or planning a pregnancy * subjects who have not undergone the specified washout period(s) for the following or requiring the concurrent use of: topical antifungal within 4 weeks; topical anti-inflammatory, corticosteroids, topical immunomodulators within 2 weeks; systemic corticosteroids within 2 weeks; systemic immunomodulators within 4 weeks. * subjects receiving systemic antifungals for treatment of onychomycosis or any systemic antifungal with known activity against dermatophytes within the previous 12 weeks or 5 half-lives of the drug, whichever is longer * subjects receiving any other treatment/therapy for the onychomycosis not previously mentioned (e.g., laser treatment) within 4 weeks * subjects with a history of significant internal disease or with a life threatening condition within the last 6 months * subjects with anatomic abnormalities of the toe(s) and or toenails * subject who have donated or lost a large volume of blood (\~500 ml or more, during the previous 6 weeks * subjects with a recent history of or currently known to abuse drugs or alcohol * subjects currently participating in another investigational medication or device study or have participated in a clinical trial within 30 days or five half-lives of the test medication

Keywords: toenail fungal infections dso
predictive value of osteopontin for contrast nephropathy

Conditions: Contrast-induced Nephropathy

Summary: early detection of contrast induced nephropathy by using osteopontin as an early marker for prediction

people who undergo coronary angiography are at risk of contrast-associated acute kidney injury (ca-aki) . the prevention therapy is the main approach to address ca-aki, minimizing the volume of contrast media and intravenous hydration before and after the procedure which may not be appropriate for those with heart failure . given limited treatment options once ca-aki develops and an unfavourable associated prognosis, early identification of those at risk of ca-aki is crucial. also, there is studies was linking ca-aki with a higher mortality rate and adverse future cardiovascular events, and risk for future ca-aki events . mehran and colleagues described ca-aki risk score predicting both ca-aki and cardiovascular events after angiographic procedures. however, studies have also investigated the role of different biomarkers in prediction of aki like osteopontin, in 2020, a consensus statement was released regarding how best to incorporate kidney biomarkers into clinical practice. osteopontin is an extracellular structural protein synthesized by various cell types like osteoblasts, smooth muscle. and found in the loop of henle and distal nephrons in normal kidneys. recent studies have found that osteopontin has a critical role in tubulogenesis, cell apoptosis, promotion of cell regeneration. lorenzen and colleagues found that critically ill patients with aki have higher osteopontin concentrations than critically ill patients without aki. few studies have investigated the role of osteopontin in the detection of aki.

Eligibility criteria:
inclusion criteria: - patients undergoing coronary with or without intervention between 2022and 2024 were prospectively enrolled at the study. patients were referred for angiography for various acute and nonacute indications, including acute coronary syndromes, heart failure, abnormal stress tests, stable chest pain, claudication, and routine preoperative evaluation. patient with ckd stage 1 or 2 only exclusion criteria: * pt has history of contrast induced nephropathy before. patient known to have chronic kidney disease stage 3a upto 5d pt has contraindication for coronary angiograghy.

Keywords: cin