Kornimate/medical-research-clean huggingface dataset:
the turkish cross-cultural adaptation, validity and reliability of vmpci

Conditions: Pain, Chronic

Summary: this study was planned to adapt the vanderbilt multidimensional pain coping inventory into turkish, to investigate its cultural adaptation, validity and reliability. the study was completed with 352 volunteers who fulfilled the criteria to be included in the rheumatology clinic of istanbul haydarpaşa numune training and research hospital. data collection tools used in the study; demographic data form, mcgill and melzack pain questionnaire, short form-36 (sf-36), vanderbilt multidimensional pain coping inventory (vmpci), pain coping inventory (pci), pain coping scale were used.

rheumatoid arthritis (ra) is a chronic, progressive, inflammatory, autoimmune disease of unknown etiology, mainly affecting synovial joints, causing loss of function. the main reason that directs ra patients to medical treatment is pain. chronic pain causes limitation of movement, sleep problems, fatigue, stress and depression, as well as physiological and psychological problems that cause negative effects on the quality of life of the individual. the patient's thoughts, expectations, and methods of coping with pain are effective in pain control. in order to identify and treat the painful condition, individual coping methods of the patient and the effectiveness of these methods should be evaluated. this study was planned to adapt the vanderbilt multidimensional pain coping inventory into turkish, to investigate its cultural adaptation, validity and reliability. the study was completed with 352 volunteers who fulfilled the criteria to be included in the rheumatology clinic of istanbul haydarpasa numune training and research hospital. data collection tools used in the study; demographic data form, mcgill and melzack pain questionnaire, short form-36 (sf-36), vanderbilt multidimensional pain coping inventory (vmpci), pain coping inventory (pci), pain coping scale were used. the language validity of the turkish form of the scale was provided by the translation-back translation method. expert opinion was obtained for scale of validity. in order to evaluate the reliability of the turkish version of the scale; internal consistency coefficient, test retest and parallel form methods were used. after all these analyzes, the reliability and validity of the turkish version of the vmpci scale was obtained. in addition to this study, the descriptive characteristics of the sample, sf-36 scale, mcgill and melzack pain questionnaire results were examined alone and together with the sub-dimensions of the scale.

Eligibility criteria:
inclusion criteria:the study included individuals whose native language is turkish, who are literate, over the age of 18, diagnosed with rheumatoid arthritis, without cognitive impairment and communication problems, and who want to participate in the study. - exclusion criteria: * individuals who do not meet the inclusion criteria are excluded from the study.

Keywords: rheumatoid arthritis, pain, coping, validity, reliability
the accuracy of sonotubometry to assess the eustachian tube

Conditions: Eustachian Tube Dysfunction

Summary: the eustachian tube (et) connects the middle ear with the throat and is important for maintaining a healthy middle ear. sonotubometry is a new method to measure how well the et works by using sound. a speaker is placed at the nostril and a microphone records sound in the external ear canal. the et is closed at rest and opens with swallowing. this is measured as an increase in sound measured in the external ear by sonotubometry. previous research has not proven that sonotubometry is reliable enough to be used in clinics to assess et dysfunction (a disease where the et does not open properly). in a recent study with healthy volunteers, it was possible to identify many of the existing issues of sonotubometry and improve the reliability of this method. this was primarily achieved by testing different sound types and sound volumes. this study aims to assess the reliability and usability of the new testing protocol in study participants with et dysfunction. the results of this study will then be compared with the results from the previous study with healthy volunteers to work out how well sonotubometry works. ultimately, this research aims to improve the ability to diagnose et dysfunction.


Eligibility criteria:
inclusion criteria: * participant is capable of giving informed consent (in the english language) * participant has a current diagnosis of obstructive eustachian tube dysfunction in the ear clinic at addenbrooke's hospital * age 16 and over exclusion criteria: * cardiac pacemaker (incompatible with the large sonotubometry speaker magnet) * discharging or infected ear (for infection control reasons) * otitis media with effusion (complicates test interpretation) * cleft palate or craniofacial abnormalities (complicates test interpretation) * cholesteatoma (complicates test interpretation) * nasopharyngeal mass (complicates test interpretation) * history of radiotherapy to the head and neck (can affect surrounding tissue structure)

Keywords: obstructive eustachian tube dysfunction eustachian tube dysfunction
interest of the echocardiography in the management of cirrhotic patients with acute kidney injury

Conditions: Cirrhosis; Hepatorenal Syndrome; Acute Kidney Injury; Diastolic Function

Summary: this prospective study focuses on the interest of the echocardiography for cirrhotic patients, who present acute kidney injury corresponding to the criteria of hepatorenal syndrome. this echocardiography will be done before the volemic expansion and the final diagnostic of hepatorenal syndrome or prerenal azotemia. the primary endpoint is to describe the hemodynamic characteristics of this population at the time of acute kidney injury and their association with diagnostic of hepatorenal syndrome or prerenal azotemia. patients with elevated filling pressure, predicting poor outcome of volemic expansion will be excluded of the study after the echocardiography and will not undergo volemic expansion but appropriate management.


Eligibility criteria:
inclusion criteria: * patients \> 18 years * written consent for the participation of the study * cirrhosis with portal hypertension and ascite * acute kidney injury according to akin criteria (rapid increase of creatinine (48 hours) \> 26.4 µmol or \> 50% comparing with baseline). baseline creatinine is the last value of creatinine before admission or creatinine at the admission if stable during 5 days. * absence of argument for acute tubular necrosis or other organic acute renal injury * absence of argument for shock exclusion criteria: * pregnant women * volemic expansion before echocardiography * portal thrombosis * presence of tipss * history of cardiac or renal pathology * atrial fibrillation * cardiac valvulopathy * technical limitation due to echogenicity

Keywords: cirrhosis hepatorenal syndrome acute kidney injury diastolic function
visio-conference for pre-hospital triage of stroke suspicions

Conditions: Stroke; Stroke, Acute; Stroke, Ischemic; Cerebrovascular Disorders

Summary: interventionnal study to investigate the accuracy of our clinical based algorithm performed by using a visioconference device to assess the eligibility of acute recanalisation treatment (intraveinous thrombolysis (ivt) and/or mechanical thrombectomie (tm). clinical identification of type of treatment is needed is pre-hospital triage of these patients.

the outcome of ischemic stroke (is) with large artery occlusion (lvo) is related to the volume of infarcted brain witch is related to the delay of arterial recanalisation. ivt is available in multiple stroke units in france but, in case of lvo, the association with tm is needed. the availability of endovascular capable centers is limited to tertiary care hospitals. as a result, pre-hospital identification of these patients is a priority and the optimization of the triage can be done by a clinical algorithm carried out by a neurological tele-evaluation. optic-avc is a multi-phase study. this phase is about the evaluation of accuracy of our algorithm performed by a quick and standardized neurological tele-evaluation to predict the eligibility for recanalisation treatment (ivt and/or tm) of patients suspected of acute stroke in the emergency setting. the effective therapeutic decision for each patient, performed by another neurologist, will be blind to the theoretical therapeutic decision resulting from the algorithm. theoretical and effective therapeutic decision will be compared a posteriori

Eligibility criteria:
inclusion criteria: * age over 18 * suspicion of acute symptomatic stroke whose first symptoms are less than 24 hours old * free consent, informed writing signed by the participant or the person of confidence and the investigator (no later than the day of inclusion and before any examination required by research) exclusion criteria: * stupor or coma requiring orotracheal intubation * rankin pre stroke \> 4 * severe cognitive impairement * contraindication to the realiszation of angiographic imaging * participation refusal * patient under legal protection

Keywords: stroke mechanical thrombectomy tele-evaluation emergency medical service pre hospital
evaluating a noise reduction algorithm with cochlear implant users

Conditions: Hearing Impairment

Summary: in this study, a noise reduction algorithm will be implemented in various listening situations to evaluate its effectiveness in improving speech understanding for cochlear implant users ages 12 and older.


Eligibility criteria:
inclusion criteria: * at least 12 years of age. * be post-lingually deafened cochlear implant recipients with at least 6 months experience regardless of manufacturer. * the pi must also deem the child to be developmentally able to complete the experiments. exclusion criteria: • anyone who is not a cochlear implant user or is aged under 12 years.
effects of breath and stacking-spirometry incentive in patients with parkinson's disease

Conditions: Parkinson's Disease.

Summary: objective: to evaluate the effects of technical-breath stacking (bs) and incentive spirometry (is) on the volume of the chest immediately after and within thirty minutes after the techniques in patients with parkinson's disease (pd). methods: this is a study of cross-over. the study investigated 14 patients with mild to moderate pd. the subjects performed the technique breath-stacking, incentive spirometry volume and participated in a phase control according to randomization. the volunteers were evaluated by opto-electronic plethysmography in four stages: before, immediately after fifteen and thirty minutes after the completion of the techniques. the investigators used a repeated measures anova with post-hoc tukey test for parametric variables, and the friedman test with post-hoc dunns for nonparametric variables. the level of significance was set at 5%, p \<0.05.


Eligibility criteria:
inclusion criteria: * regular pharmacological treatment with levodopa and / or medications antiparkinsonian. exclusion criteria: * patients who had previous lung disease; * altered mental status indicated by the mmse (mini mental state examination; * a change in medication during the study; * demonstrated inability to perform satisfactorily any of the collection procedures of the study.
development of a new early detection test to reduce racial disparities in endometrial cancer (ec) death rates

Conditions: Endometrial Carcinoma

Summary: this phase i trial investigates the development of a new early detection test to reduce racial disparities in endometrial cancer death rates. dna samples collected from a tampon may be able to be used to detect endometrial cancer. studying information from focus groups and vaginal samples of african american and white women may help researchers develop a less invasive and painful test to detect endometrial cancer. the purpose of this trial is to perform a demonstration project of tampon self-collection, assess percentage of samples returned; total and endometrial derived dna quantity and quality, preliminarily test previously validated dna methylation markers that may discriminate endometrial cancer from normal endometrium in tampon specimens.

primary objectives: i. to conduct focus groups to elicit perceptions and knowledge among african american women (aaw) and white women (ww) concerning abnormal uterine bleeding (aub)/post-menopausal bleeding (pmb), endometrial cancer (ec) risk factors, barriers to seeking medical evaluation, sources of medical information and acceptance and feasibility of tampon self-collection for laboratory testing. ii. to perform a demonstration project of tampon self-collection from 25 aaw and 25 ww with aub/pmb in jacksonville. outline: aim 1: participants attend a focus group over 2 hours about endometrial cancer including knowledge of abnormal uterine bleeding, post-menopausal bleeding, risk factors, sources of medical information, barriers to seeking gynecologic care, and acceptance of tampon self-collection for endometrial cancer detection. aim 2: participants receive a tampon kit for collection of vaginal samples. after completion of study enrollment, participants may be followed up annually for 10 years.

Eligibility criteria:
inclusion criteria: * aim 1: self-identified white women (ww) or african american women (aaw) (will record hispanic ethnicity) * aim 2: self-reported history of abnormal uterine bleeding (aub) or post-menopausal bleeding (pmb) exclusion criteria: * aim 1: women who do not identify as ww or aaw * aim 1: women who are unable to speak and read english * aim 2: prior hysterectomy * aim 2: prior pelvic radiation or are unwilling to comply with instructions * aim 2: pregnant women
rotem assessment of modern crystalloid, hydroxyethyl starch and gelatin effect on coagulation

Conditions: Coagulopathy

Summary: modern crystalloid and colloid solutions are balanced solutions which are increasingly used in perioperative period. however, studies investigating their negative effect on whole blood coagulation are missing. the aim of our study was to assess the effect of modern balanced crystalloid and colloid solutions on whole blood coagulation in vivo using rotational thromboelastometry.

blood samples were obtained from 30 patients during knee arthroscopy before and after administration of 500 ml of modern balanced crystalloid, hydroxyethyl starch (hes) or gelatin. rotational thromboelastometry (extem, intem and fibtem tests) were performed to assess negative effect of fluid solutions on whole blood coagulation.

Eligibility criteria:
inclusion criteria: * healthy patients undergoing knee arthroscopy exclusion criteria: * receiving antiplatelet drugs

Keywords: hydroxyethyl starch, gelatin, rotem, coagulation
early detection and risk stratification of colorectal cancer based on mirna platform

Conditions: Colorectal Cancer

Summary: this is a prospective, observational cohort study to establish the minimal residual disease (mrd) model for predicting relapse risk and identifying disease recurrence in patients with colorectal adenocarcinoma based on the mirna platform. blood mirna markers will be evaluated. the study will enroll approximately 600 participants, including participants with malignancies or benign diseases, and healthy participants.


Eligibility criteria:
inclusion criteria: inclusion criteria for the colorectal cancer arm: 1.18-75 years old 2. pathologically confirmed as colorectal adenocarcinoma 3. medically able to receive radical surgery for colorectal cancer 4. eastern cooperative oncology group (ecog) performance-status score of 0 to 1 5. ability to provide a written informed consent inclusion criteria for the healthy control arm: 1.18-75 years old 2. no clinically significant finding based on routine blood tests, urinalysis, ct, and ultrasound examinations 3. ability to provide a written informed consent inclusion criteria for the intestinal polyp arm: 1.18-75 years old 2. pathologically confirmed as colorectal adenoma 3. ability to provide a written informed consent exclusion criteria: 1. history of other malignant tumors (excluding non-melanoma skin cancer). 2. prior or related treatments previously (including colorectal cancer or advanced adenoma surgery, endoscopic treatment, chemotherapy, targeted therapy, immunotherapy, radiation, neoadjuvant therapy, etc.). 3. patients with hereditary colorectal diseases (including lynch syndrome, familial crc type x (fccx), familial adenomatous polyposis (fap), muthy-associated polyposis (map), peutz-jeghers syndrome (pjs), juvenile polyposis syndrome (jps), serrated polyposis syndrome (sps), etc.). 4. usage of anti-tumor drugs such as methotrexate, cyclophosphamide, mercaptopurine, and bendamustine for other diseases within 30 days before blood collection. 5. prior blood transfusion (including blood components) within the past 2 weeks. 6. prior organ transplantation, bone marrow transplantation, or stem cell transplantation. 7. pregnancy women. 8. acute inflammation or fever requiring drug escalation within 14 days prior to blood collection. 9. inability to comply with study procedures such as blood collection and related examinations. 10. deemed unsuitable for participation in the clinical trial by the investigator.
a long-term safety study of fluticasone furoate (ff)/gw642444 and ff in japanese subjects with asthma

Conditions: Asthma

Summary: the primary purpose of the study is to assess the safety and tolerability of 52-week teatment with fluticasone furoate/gw642444 inhalation powder once-daily and ff inhalation powder once-daily in japanese adult subjects with asthma.


Eligibility criteria:
inclusion criteria: * out patient at least 18 years of age * both genderds; females of childbearing potential must be willing to use birth control method * a diagnosis of asthma at least 6 months prior to screening * a best fev1 of at least 50% of the predicted nomal value at screening * subjects have been receiving maintanance therapy for asthma, for at least 4 weeks prior to screening exclusion criteria: * history of life-threating asthma * respiratory infection or oral candidiasis * asthma exacerbation within 12 weeks * concurrent respiratory disease or other disease that would confound study participation or affect subject safety * allergies to study drugs, study drugs7 excipients, medications related to study drugs * taking another investigational medication or medication prohibited for use during this study

Keywords: asthma fluticasone furoate gw642444
empowerment-based complementary and alternative medicine (ecam)

Conditions: Diabetes

Summary: this phase study will use a randomized trial method to evaluate the performance of the ecam educational app in the promotion of cam health literacy and communication among patients with diabetes.

the objectives of this phase study are to (1) implement the ecam educational app to empower patients with diabetes in their management of diabetes alongside cam use; (2) examine the impact of the ecam educational app on patient empowerment, cam health literacy, risk management of cam use, cam communication and diabetes quality of life in patients with diabetes; and (3) collect feedback from both patients and nurses on how to improve the ecam educational app for dissemination and implementation.

Eligibility criteria:
inclusion criteria: * people over the age of 20 * diagnosis of diabetes at least 12 months before the interview; and * the use of cam at least 3 months * sufficient mental ability to understand the informed consent form and sign it. exclusion criteria: * participants will be excluded by an assistant researcher if they serious physical condition and hard of hearing and seeing.

Keywords: complementary and alternative medicine (cam) patient education empowerment health literacy application diabetes
effects of stress on glucose tolerance during pregnancy

Conditions: Pregnancy; Stress; Gestational Diabetes

Summary: the objective of the study is to investigate the effect of stress on glucose tolerance during pregnancy. the main objectives of the study are to investigate if various measures of stress (stressful life events, the perceived level of stress and the cortisol or copeptin concentrations) differ between pregnant women with and without gestational diabetes during the end of the second/beginning of the third trimester when presenting for their routine glucose tolerance testing. secondary objectives are the link between these different stress measures and the routinely measured fasting and stimulated glucose levels during the oral glucose tolerance test.

hypotheses in this study, 3 primary hypotheses will be tested. 1. women with gestational diabetes have more life events compared to pregnant women without gestational diabetes. 2. women with gestational diabetes have higher perceived level of stress and anxiety compared to pregnant women without gestational diabetes. 3. women with gestational diabetes have higher measures of cortisol levels in the saliva and in the nailfolds and higher plasma copeptin levels compared to pregnant women without gestational diabetes. secondary objectives: 1. to test the link between these stress measures and the fasting and stimulated glucose levels during the oral glucose tolerance test.

Eligibility criteria:
inclusion criteria: * all pregnant women who are undergoing a 75 g oral glucose tolerance test at the "maternité" of chuv at 24-30 weeks of gestation between october 2012 and april 2013 exclusion criteria: * pregnant woman who has the use if medications that influence either the cortisol and /or the glucose levels * pregnant woman who has the inability to fill out the questionnaires with assistance

Keywords: pregnancy stress anxiety cortisol copeptin gestational diabetes