Kornimate/medical-research-clean huggingface dataset:
evaluation of an integrated microfinance and depression care program for women

Conditions: Depression

Summary: the study evaluates life-dm, an integrated microfinance and collaborative care intervention by comparing it to enhanced treatment as usual (national guideline antidepressant care and referral to microfinance resources) in vietnam. intervention effects at baseline, 6 month, and 12 month follow-up on patient outcomes, including depression, anxiety, quality of life, functioning, self-efficacy, satisfaction, and income will be compared across the two conditions.

depression is one of the largest contributors to the world's health burden. prior work in the partners in care study has shown that evidence-based service delivery programs for depression can improve health outcomes in depressed patients, and especially in minorities, largely overcoming disparities in outcomes from care between whites and minorities. effective treatments exist, but they do not reach many depressed individuals, especially in resource-poor communities--ethnic minorities, rural residents in the united states, and individuals in most of the developing world. women, in particular, are at risk for depression and poverty. integrating programs that treat depression and address livelihood concerns may improve engagement in depression treatment and improve mental health and functioning for patients in low-resource settings. the proposed study would integrate depression care with existing "microfinance" programs, which provide poverty-alleviation services including small loans, savings programs, and vocational training to women. this project will (1) conduct qualitative studies of barriers and facilitators of women's successful use of existing depression care and microfinance programs; (2) adapt and integrate the depression care and microfinance services; (3) train women's union facilitators to deliver the integrated depression care and microfinance program; and conduct evaluation of life-dm program to assess acceptability, feasibility, and preliminary effectiveness. the non-randomized control trial compares the integrated microfinance and collaborative care intervention with enhanced treatment as usual (national guideline antidepressant care and referral to microfinance resources) at the women's union in danang city in vietnam.

Eligibility criteria:
inclusion criteria: * depression, low-income exclusion criteria: * psychosis, mania, substance abuse, high suicide risk, physical disabilities, significant cognitive impairments

Keywords: behavior activation problem solving therapy depression treatment depression care integration microfinance livelihood
an educational intervention on provider knowledge for the support of cancer survivors

Conditions: Hematopoietic and Lymphoid Cell Neoplasm; Malignant Solid Neoplasm

Summary: this clinical trial utilizes the project extension for community healthcare outcomes (echo) model to recruit, train, and support community healthcare providers in cancer survivorship best practices. cancer survivors have distinct medical needs and are more likely to report being in poor or fair overall health compared to those who do not report a history of cancer. there is a lack of educational opportunities focused on survivorship care for health providers. although progress has been made with the development of survivorship guidelines, physicians continue to express barriers to addressing concerns of cancer survivors. this study is to utilize a survivorship echo education intervention to assess its effects on provider knowledge and comfort with survivorship guidelines as well as greater adherence to guideline concordant breast cancer survivorship care recommendations.

primary objectives: i. determine the effectiveness of the survivorship echo's platform by assessing provider knowledge of cancer survivorship best practices using pre- and post-enrollment surveys. ii. evaluate implementation of survivorship best practices into clinical practice and documentation after enrollment in our survivorship echo. outline: participants attend 6 sessions of survivorship echo educational intervention over 1 hour each, every 2 weeks for 12 weeks. participants may optionally participate in a one-on-one interview to give feedback about the sessions over 30 minutes.

Eligibility criteria:
inclusion criteria: * providers from the james cancer network (consists of five community sites in ohio: st. rita's memorial center, memorial health, madison health, wooster community hospital, and clinton memorial hospital) * eligible participants will include registered nurses, advanced practice registered nurses, physician assistants, nutritionists, radiation oncologists and oncologists
mindfulness-oriented recovery enhancement for chronic pain patients receiving opioid therapy

Conditions: Chronic Pain; Opioid Abuse, Unspecified Use

Summary: persons suffering from chronic pain who are treated with long-term opioid therapy are at risk of misusing prescription opioids and developing opioid addiction. moreover, long-term use of opioids may result in hyperalgesia, which exacerbates opioid craving and consumption. mindfulness interventions have been shown reduce chronic pain symptoms, addictive processes, and substance use. the investigators hypothesize that relative to a support group control condition, participation in a novel mindfulness-oriented cognitive intervention, mindfulness-oriented recovery enhancement (more), will result in improved well-being and decreased pain, opioid craving, and opioid misuse behaviors among chronic pain patients receiving opioid therapy.

few behavioral treatments target the cognitive-affective mediators of opioid misuse and addiction in chronic pain patients. as such, novel, multimodal interventions are needed to effectively target key mechanisms in the risk chain from chronic pain to opioid misuse and addiction. the secondary aim of this study is to explore possible cognitive, affective, and psychophysiological mediators of intervention effects on pain, opioid craving, opioid misuse behaviors, and well-being.

Eligibility criteria:
inclusion criteria: * chronic pain diagnosis (icd-9 diagnoses 338.xx) * treatment with prescription opioids for \> 3 months exclusion criteria: * prior mindfulness training * persons who are experiencing acute opioid withdrawal * suicidal ideation * psychosis
oropharyngeal immunoprophylaxis with high polyphenolic olive oil as clinical spectrum mitigating factor in covid-19.

Conditions: COVID-19

Summary: immunomodulation of local immune response at the oropharyngeal mucosa can hypothetically activate mucosal immunity, which can difficult sars-cov-2 main immune evasion mechanisms in early stages of the disease and send an effective warning to the adaptive immune system. there are previous studies on immunotherapeutic management of upper respiratory tract infections with olive polyphenols. the investigators would like to study if participants following oromucosal immunomodulation with tiny quantities of high polyphenolic olive oil (early harvest olive oil) could have more possibilities to have less severe symptoms and a better outcome after sars-cov-2 infection.


Eligibility criteria:
inclusion criteria: * adult men and non-pregnant women were eligible if they had been in contact of recent covid-19 diagnosed people and radomly allocated to olive oil group or not treatment at all group. exclusion criteria: 1. participation in other studies the 6 months before. 2. pregnant women. 3. inabilty to oral feeding. 4. diagnosis of any pathology able to increase risk.

Keywords: covid-19
modalities of surgical treatment of chiari malformation disease : clinical study and outcomes

Conditions: Chiari Malformation, Type 1

Summary: evaluation of postoperative outcomes of chiari type i malformation patients at department of neurosurgery assiut university hospital .

chiari malformation is a group of craniocervical malformations involving the brain stem, cerebellum, upper spinal cord, and surrounding bony structure, encompassing a series of hindbrain herniation symptoms. the austrian pathologist hans chiari ﬁrst described the malformation in 1891 and such abnormality is frequently identiﬁed in both young adult and pediatric patients. there are four main types of chiari malformations with other subtypes. chiari i malformation (cim), in which the caudal poles of the cerebellar tonsils extend into the upper cervical spinal canal, is a common clinical type. common clinical symptoms, including headache, altered sensation, weakness, dysphagia, sleep apnea. between 70% and 80% of patients with cim have accompanying syringomyelia. surgical treatment is widely accepted and is the only treatment chosen for symptomatic patients with chiari malformations. the aim of this study is to elucidate the most favorable procedures for cim in terms of radiological and clinical outcomes. independent and dependent variables will be identiﬁed for analysis. the independent variables will include patient diagnosis, surgical techniques, patient age, patient chronic diseases and identified dependent variables including improvement of symptoms and signs, rates of intraoperative and postoperative adverse events, and perioperative mortality. different surgical modalities will be applied ,examples include bony decompression with or without duraplasty with the possibility of cerebellar tonsils resection (rt) . common complications include meningitis, csf leak, pseudomeningocele, hydrocephalus, respiratory failure, hemorrhage, craniocervical instability, and/or death. the outcome will be measured by reduction / increase of symptoms and signs using the chicago chiari outcome scale (ccos).

Eligibility criteria:
inclusion criteria: * chiari i malformation patients who suffer from clinical symptoms and radiological manifestations. * patients fit for surgery exclusion criteria: * other types of chiari malformations * patients with multilevel cervical disc herniation . * patients with segmental instability . * patients unfit for surgery
holistic needs assessment in outpatient cancer care

Conditions: Oncology [See Also, Affected System]

Summary: this study evaluates the impact of holistic needs assessment (hna) on patient/clinician communication in outpatient cancer care. half of the participants will complete a hna prior to their clinical consultation. they will then take it into the consultation and it will inform a discussion around any identified areas of need. half of the participants will be in the control group meaning there will be no additional intervention they will receive care as normal. the consultations will be audio-recorded. the patient will complete two outcome measures following the consultation.

holistic needs assessment is a checklist completed by the patient prior to consultation. it signposts issues of emotional, practical, financial and clinical concern. the purpose of a hna is to identify patient's individual needs in order to facilitate better collaboration. during consultation the hna facilitates a dialogue that will have the patient's concerns at the centre. in conjunction with a subsequent care plan the process supports timely intervention based on a collaborative, person centred discussion. however, there is little evidence on how hna impacts upon the dynamics of the clinical consultation. this study aims to establish a) how hna affects the type of conversation that goes on during a clinical consultation and b) how these putative changes impact on shared decision-making and self-efficacy.

Eligibility criteria:
inclusion criteria: * over 18, capable of informed consent and expresses a wish to participate. * diagnosed with cancer and attending a post-treatment out-patient oncology clinic. exclusion criteria: * individuals not diagnosed with cancer. * non english speaker * person deemed incapable of consenting to participate as defined by the adults with incapacity act (2000) * any reason which in the opinion of the clinician/investigator interferes with the ability of the patient to participate in the study
effect of aloe vera gel as an intra canal medicament

Conditions: Periapical Diseases

Summary: this research will overview the effect of aloe vera gel (avg) as intra canal medicament in patients with asymptomatic periapical lesions. it will provide endodontists with scientific evidence regarding the beneficial use of avg as an intracanal medicament owing to its superior antibacterial and analgesic properties as compared to routinely used commercial intra canal medicaments.

objective: to evaluate the effect of aloe vera gel based on clinical signs and symptoms as an intracanal medicament in asymptomatic periapical lesions over a period of three weeks. methodology: fresh avg will be prepared. it will be placed as intracanal medicament after cleaning and shaping in patients with asymptomatic periapical lesions in group a while in group b (control group) no intracanal medicament will be placed. patients will be randomly divided into two groups by randomization in statistical package for social sciences software (spss v24.0). they will be recalled for one week and three week follow ups and in case of no clinical signs and symptoms endodontic procedure will be completed. statistical analysis: descriptive statistics will be used for reporting age. frequencies and percentages will be calculated for categorical variables and intergroup comparison will be done by chi square test

Eligibility criteria:
inclusion criteria: * both male and female patients presenting with asymptomatic periapical lesions in permanent teeth exclusion criteria: * history of allergy to avg * comorbidities likely to impair healing * pregnant women * history of previous endodontic treatment in the same tooth * presence of pulp calcification * internal or external root resorption

Keywords: antibacterial, analgesic, clinical signs and symptoms
a 13-week, randomized, double-blind, multicenter, placebo-controlled study of pregabalin for postherpetic neuralgia

Conditions: Neuralgia, Postherpetic

Summary: the purpose of this study is to evaluate efficacy and safety of pregabalin in the treatment of postherpetic neuralgia in a dose-ranging manner.


Eligibility criteria:
inclusion criteria: * visual analogue scale (vas) of pain is higher than 40 mm. * pain is sustained for more than 3 months after healing of herpes zoster skin rash. exclusion criteria: * malignancy within the past 2 years. * patients who have undergone neurolytic or neurosurgical therapy for postherpetic neuralgia. * creatinine clearance \</= 30 ml/min (estimated from serum creatinine, body weight, age, and sex using the cockcroft and gault equation, by omitting any decimal fractions). * patients having other severe pain which may impair the self assessment of the pain due to postherpetic neuralgia. * skin conditions in the affected dermatome that could alter sensation.
sofosbuvir/velpatasvir fixed-dose combination in adults with chronic hcv infection and child-pugh class b cirrhosis

Conditions: Hepatitis C Virus Infection

Summary: the primary objectives of this study are to evaluate the efficacy, safety, and tolerability of sofosbuvir (sof)/velpatasvir (vel) fixed dose combination (fdc) with and without ribavirin (rbv) for 12 weeks and sof/vel fdc for 24 weeks in adults with chronic hepatitis c virus (hcv) infection and child-pugh-turcotte (cpt) class b cirrhosis.


Eligibility criteria:
inclusion criteria: * willing and able to provide written informed consent * hcv rna \> 10\^4 iu/ml at screening * chronic hcv infection (≥ 6 months) * confirmed cpt class b (7-9) at screening exclusion criteria: * current or prior history of solid organ transplantation, significant pulmonary disease, significant cardiac disease, or porphyria * inability to exclude hepatocellular carcinoma (hcc) by imaging within 6 months of baseline/day 1 * infection with hepatitis b virus (hbv) or human immunodeficiency virus (hiv) * screening ecg with clinically significant abnormalities * prior exposure to sof or any other nucleotide analogue hcv nonstructural protein 5b (ns5b) inhibitor or any hcv ns5a inhibitor * laboratory results outside of acceptable ranges at screening

Keywords: sofosbuvir velpatasvir sof/vel gs-5816 hepatitis c hcv cirrhosis cpt-b
biweekly gemcitabine-oxaliplatin and dexamethasone for relapsed/refractory malignant lymphoma

Conditions: Lymphoma

Summary: - to evaluate the feasibility of combination chemotherapies comprising of gemcitabine-dexamethasone-oxaliplatin for patients with refractory or relapsed malignant non-hodgkin lymphoma (nhl)

- the feasibility will be evaluated in terms of objective response rate, efficacy of stem cell collection, disease-free survival, and overall survival.

Eligibility criteria:
inclusion criteria: * patients who have refractory to first-line chop-like regimen * patients who have first relapse after * first-line chop-like regimen * upfront autologous or allogeneic hematopoietic stem cell transplantation * age 15 years or more * ecog performance status ≤ 2 * adequate bone marrow function * adequate kidney,liver,cardiac exclusion criteria: * patients who have received gem or ox
energy device study in transoral endoscopic thyroidectomy

Conditions: Thyroid Nodule; Thyroid Cancer

Summary: open label randomized controlled study, for harmonic versus ligasure in transoral endoscopic thyroid surgery.

* this is a prospective randomized controlled study. the principal investigator or another clinical investigator in charge will individually inform the patients about the study, on the day before surgery. * when informed consent is obtained, an investigator in charge of randomization only, will randomize the patients. * according to randomization, the experimental group will ligasure and the control group will use harmonic ace 7+. other than the randomized use of energy devices, the protocol for toetva is performed as usual. * operation time (from insertion of the laparoscopic camera to removal of the camera), number of times the camera was cleaned, intraoperative blood loss will recorded. * postoperative hospital stay, visual analog pain scale, blood cell count and inflammatory parameters, postoperative drain amount will recorded. * complications of thyroid surgery (vocal cord dysfunction, hypoparathyroidism) are compared for safety assessment.

Eligibility criteria:
inclusion criteria: * patients who planned to transoral endoscopic thyroidectomy * age between 20 to 70 * voluntarily consenting to the study and study agreement * no local invasion or distant metastasis * normal vocal cord function in laryngoscopic exam * no significant abnormalities in preoperative laboratory tests exclusion criteria: * take aspirin or antiplatelet drugs within 7 days before admission * uncontrolled hypertension, diabetes, chronic renal failure, or coagulation disease * history of cardiovascular disease (angina pectoris, heart failure, myocardial infarction, history of coronary artery disease, stroke, transient ischemic attack) * substance abuse and alcohol abuse * history of esophageal and airway diseases * patient was participated in other clinical trials within 30 days * history of neck irradiation or surgery * history of severe drug allergies * pregnant or lactating women
chroendohnpcc: early detection of pre-cancer lesions in adults with hereditary nonpolyposis colorectal cancer syndrome

Conditions: Colorectal Neoplasms, Hereditary Nonpolyposis

Summary: the aim of the study is to test the hypothesis that a chromoscopy colonoscopy is able to increase by 50 % the number of pre-cancer lesions or early cancer detected in patients with hnpcc syndrome, compared to a routine colonoscopy without chromoscopy.

patient with hnpcc syndrome confirmed by a mutation (mlh1, msh2, mhs1) are involved in the study. patient have 2 colonoscopy back to back. the second coloscopy is associated to chromoscopy with carmin indigo. endoscopist are randomised for the colonoscopy with chromoscopy and are un-awarded of the result of the first colonoscopy. histopathology of the polyp are noted. the follow up were 1 month.

Eligibility criteria:
inclusion criteria: * patients with mlh1, msh2 or msh6 mutation. * patients concerned by early detection colonoscopy. exclusion criteria: * coloscopy of tracking since less 1an * occlusive syndrome contra-indicating the preparation for a total coloscopies * colectomies * medical conditions or serious illnesses contra-indicating a coloscopy of screening * pregnant woman or nursing * anomaly of coagulation contra-indicating the realization of biopsies and/or the exeresis of the lesion colorectal

Keywords: colorectal cancer hnpcc diagnosis coloscopy chromoscopy indigo carmine colorectal neoplasms hereditary nonpolyposis
repeatability and reproducibility of the adc map in head and neck cancer. prospective multicenter study

Conditions: Head and Neck Carcinoma

Summary: evaluation of the repeatability and reproducibility of adc maps in both primary and non-primary lesions lymph nodes in patients with head and neck cancer, using an acquisition protocol standardized dwi

dwi imaging consists of a spin-echo echo-planar sequence (se-epi) that will be acquired with 1.5 t or 3 t tomographs according to the equipment of the individual centers involved, setting the acquisition parameters after the administration of any contrast medium.

Eligibility criteria:
inclusion criteria: * age over 18 years; * primary squamous cell carcinoma (scc) of the hypopharynx, oropharynx, or oral cavity; confirmed by histology; * a lesion visible on at least three consecutive dwi images, with a minimum diameter of 2 cm; * specific written informed consent; exclusion criteria: * incomplete acquisition of dwi images; * presence of artifacts that do not allow quantitative analysis of dwi images; * performance status 2 or more according to zubrod.
a single-center, prospective, clinical study of versawrap utilization in the hand

Conditions: Tendon Repair; Fracture Repair; Tenolysis

Summary: the purpose of this study is to evaluate the efficacy on the use of versawrap® in surgery of the hand/fingers, including tendon repair, fracture repair, or tenolysis of the hand/fingers. versawrap is designed to allow tendon gliding and to protect tendon gliding postoperatively

this is a prospective, post-market, observational, single center study evaluating the use of versawrap. patients identified by the investigator in his practice as needing surgery of the hand/fingers and meeting all the inclusion and none of the exclusion. patients will consent to participating in the study, prior to any study procedures.

Eligibility criteria:
inclusion criteria: 1. patients aged 18-70 at the time of surgery 2. patients undergoing hand/finger surgery, including tendon repair, fracture repair or tenolysis 3. psychosocially, mentally and physically able to fully comply with this protocol including adhering to follow-up schedule, study requirements with a signed informed consent with a study collaborator present at the time of signing to ensure compliance. exclusion criteria: 1. non-english speaking 2. known allergy or sensitivity to citrate, alginate or hyaluronate 3. pregnant or breastfeeding 4. currently a prisoner 5. patient has any condition, that in the opinion of the investigator, would prohibit the patient from complying with the protocol