Kornimate/medical-research-clean huggingface dataset:
dry needling and patients treatment expectations

Conditions: Neck Pain; Dry Needling; Motivation

Summary: objectives the aim of this study is to compare the effects of inducing positive expectations against negative or neutral induced expectations on the activation of the autonomic nervous system and the analgesic response, after a dry needling technique in upper trapezius fibers in patients with unspecific neck pain. summary theoretical framework: dry needling has proven its efficacy for the treatment of myofascial trigger points. moreover, it has proven its effects over the central nervous system and the autonomic nervous system (ans). despite that previous studies have researched the role of patient's expectations and their relationship with the results of treatment, there is insufficient information concerning the effects of inducing expectations and the activation of the ans during the application of widely used therapies, such as dry needling.

the aim of this study will be to research the effects of induced expectations combined with a dry needling technique on the activation of the ans and on the results of the treatment. hypothesis: the induction of a positive expectation shall cause a greater analgesic response associated with a response in the ans compared to the induction of neutral or negative expectations. methods: patients with neck pain will participated in this randomized clinical trial, which will be randomly assigned into 3 groups in order to receive positive, neutral or negative expectations concerning the treatment, by means of an individual informative talk. all subjects will received treatment using dry needling in the upper trapezius fibers. the main variables measured will be the following: analogic visual scale, pressure pain threshold using a mechanical force gage (before and after) and the activation of the ans measuring the skin conductance, skin temperature, heart rate and breathing rate (monitored for 5 minutes before the intervention, during and 20 minutes afterwards).

Eligibility criteria:
inclusion criteria: * neck pain. * hiperalgesic point in upper trapezius muscle. exclusion criteria: * pain irradiation toward upper limb * psychological disorders * whiplash. * neuropathic symptoms * cervical and / or shoulder spine surgery
jaw-thrust on postoperative sore throat

Conditions: General Anesthesia

Summary: this investigation is planned to compare the incidence and severity of postoperative sore throat according to the use of two-handed jaw thrust maneuver in patients undergoing endotracheal intubation for general anesthesia.


Eligibility criteria:
inclusion criteria: * asa i-iii * patients scheduled for general anesthesia with endotracheal intubation exclusion criteria: * difficult airway * mallampatti scores greater than 2 * recent sore throat * cervical spine disease * recent upper respiratory infection * recent analgesics * history of head and neck surgery * friable teeth * multiple intubation attempts
l-arginine add-on therapy in patients with schizophrenia

Conditions: Schizophrenia; Schizoaffective Disorder

Summary: this study evaluates the addition of l-arginine to the usual regimen in the treatment of schizophrenia in adults. as a requisite of crossover design, half of the participants started with l-arginine and the other half with placebo and switched over after a three weeks use and one week of a washout period.

l-arginine is the precursor of nitric oxide (no), a neuromodulator of dopamine, gamma-aminobutyrate (gaba) and glutamate systems. nitric oxide donors which increase no levels at the cellular level could improve n-methyl-d-aspartate (nmda) receptor dysfunction. using l-arginine could bypass the blocked nmda receptors and improve the therapeutic efficacy by reversing the dysfunction. the investigators proposed that using l-arginine, a dietary supplement in most cultures, might constitute a safe option as an add-on treatment which may display beneficial effects on positive, negative, cognitive and affective symptoms associated with schizophrenia.

Eligibility criteria:
inclusion criteria: * schizophrenia-schizoaffective disorder * clinical global impression \>4 * able to take oral medication and likely to comply the required evaluations * on stable medication regimen for 8 weeks * competent and willing to give informed consent exclusion criteria: * uncontrolled medical illness (renal disease, hepatic, cardiac diseases, gout, asthma, diabetes, sickle cell anemia, low-high blood pressure) * history of myocardial infarction (mi) * history of genital herpes infections/ receiving lysine containing treatments * pregnancy/ lactation * substance related and addictive disorders * drugs that might induce hypotension * intolerance to l-arginine and ingredients of placebo or l-arginine capsule

Keywords: schizophrenia l-arginine nitric oxide drug augmentation
glimepiride induced insulin secretion will be inhibited by hypoglycemia

Conditions: Type 2 Diabetes

Summary: this study will look at two fda approved medications that improve how the pancreas works in patients with type 2 diabetes. in order to understand how these medications work in patients with diabetes we must first measure the normal response in healthy volunteers without diabetes. we will be looking at the body's normal physiological response to low blood sugar and whether this will be modified by these medicationsthe hypothesis would be that glimepiride induced insulin secretion will be inhibited by hypoglycemia.

in patients with type 2 diabetes, sulfonylurea drugs are a mainstay for effective glucose control. these agents produce their hypoglycemic effects via stimulation of endogenous insulin secretion. oversecretion of insulin, per se, or a continued relative increase of the hormone even when plasma glucose is normal will result in hypoglycemia. this latter situation commonly occurs if a patient decides to omit, delay, or reduce the size of a meal. an important defense against hypoglycemia in the above situations is glucose dependent regulation of insulin secretion. in other words, a low ambient glucose concentration could regulate the magnitude of the amount of insulin released in response to a sulfonylurea. thus during hypoglycemic conditions, the sulfonylurea would result in little or no insulin secretion, whereas its effects during hyperglycemia would be amplified. glimepiride and glyburide are both second-generation sulfonlyurea drugs used commonly for treatment of type 2 diabetes. this study will compare the two and ask the following question: is glimepiride insulin secretion dependent upon glucose concentration in-vivo?

Eligibility criteria:
inclusion criteria: * healthy male and female subjects aged 30-60 * body mass index 21-30 kg/m2 * all potential volunteers will have routine blood test to screen for hepatic, renal, and hematological abnormalities * ekg treadmill stress test for volunteers over 40 years of age. * female volunteers of childbearing potential will undergo hcg pregnancy test. exclusion criteria: * prior or current history of poor health * abnormal results following screening tests * pregnancy * history of allergy to sulfonylurea or related drugs

Keywords: epinephrine glucose clamp
clinical evaluation of systane® balance in dry eye subjects

Conditions: Dry Eye

Summary: the purpose of this study is to evaluate the efficacy and safety of systane® balance following 90 days of qid (4 times/day) dosing among indian subjects with dry eye.

this study was conducted in india.

Eligibility criteria:
inclusion criteria: * sign informed consent and willing and able to attend all study visits; * dry eye in both eyes diagnosed by an ophthalmologist; * other protocol-specified inclusion criteria may apply. exclusion criteria: * women of childbearing potential who are pregnant or breastfeeding; * any medical condition (systemic or ophthalmic) that may preclude the safe administration of test article or safe participation in the study; * ocular surgery or ocular trauma requiring medical or pharmacological treatment within 1 year of screening; * use of topical ocular prescription or non-prescription medications, restasis or topical ocular steroids within 14 days of screening; * use of any artificial tears/gels/lubricants/rewetting drops within 4 hours of screening; * contact lens wear within 1 week of screening and/or unwillingness to discontinue contact lens wear for the duration of the study; * other protocol-specified exclusion criteria may apply.
pharmacokinetics and safety of solithromycin in adolescents and children

Conditions: Bacterial Infection

Summary: pediatric study to evaluate the safety and pharmacokinetics of solithromycin (oral and intravenous) in children ages 0 to 17


Eligibility criteria:
inclusion criteria: * suspected or confirmed bacterial infection with organisms against which solithromycin is expected to be active. exclusion criteria: * serum creatinine \>2 mg/dl * positive pregnancy test in females of childbearing potential * history of intolerance or hypersensitivity to macrolide antibiotics
a registry of subjects with primary indeterminate lesions or choroidal melanoma

Conditions: Choroidal Melanoma; Indeterminate Lesions of Eye

Summary: the purpose of this observational research study is to follow participants who have been treated with either bel-sar or received alternate treatment (sham, standard of care therapy, etc.) while participating in a previous aura biosciences clinical research study to assess the long-term safety and effectiveness in these subjects. this study will collect information from procedures conducted as part of routine follow-up eye care and cancer care. additionally, the registry will collect all adverse events, information about pregnancy and symptomatic overdose.

this is a multi-center long-term observational registry of subjects with primary indeterminate lesions or choroidal melanoma. the registry will initially be open to subjects who have previously participated in an aura biosciences bel-sar sponsored clinical trial for their primary choroidal melanoma or indeterminate lesions. all subjects will be followed for a minimum of 5 years (including time enrolled in an aura sponsored clinical trial), until withdrawal of consent, or until death whichever comes first. no interventions will be required as part of the registry. data collection will be based on il or cm information anticipated to be available based on the standard of care for subjects with cm or il.

Eligibility criteria:
inclusion criteria: * have been clinically diagnosed with primary il or cm at the time of entry to a previous aura biosciences sponsored clinical trial. * have received au-011 bel-sar or assigned to a different cohort or treatment arm (sham, soc, etc.) an observation cohort in a previous aura sponsored clinical trial. exclusion criteria: - none

Keywords: choroidal melanoma indeterminate lesions of eye
one-stage versus two-stage revision of the infected knee arthroplasty

Conditions: Periprosthetic Knee Infection

Summary: this study investigates functional outcome and safety after one-stage versus two-stage revision of the infected knee arthroplasty. half of participants are treated with a one-stage surgical procedure, while the other half is treated with a two-stage procedure. the investigators hypothesize that the functional outcome and quality of life of the participants is superior after one-stage surgery compared to two-stage surgery.

a two-stage approach is the standard surgical procedure in the treatment of the chronically infected knee arthroplasty, but promising results have been reported after a one-stage approach from single-centre studies. the potential benefits for the patients treated with a one-stage approach are many as they only have to go through surgery and rehabilitation once with shorter total length of hospital stay. however, no randomized controlled trials comparing outcome after the procedures have been performed so far.

Eligibility criteria:
inclusion criteria: * clinical signs of periprosthetic knee infection * \> 6 weeks from previous knee arthoplasty procedure (primary or total revision procedure) * speak and understand danish and have given informed consent exclusion criteria: * soft tissue problems requiring plastic surgery * major bone loss requiring mega/tumor-prosthesis * acute surgery due to sepsis * malignant disease with less than 2 years life expectancy * re-infection with previous two-stage procedure * bilateral knee infection

Keywords: infection knee arthroplasty surgical treatment one-stage two-stage outcome
blac - treatment of cutaneous warts in immune suppressed, kidney transplanted patients

Conditions: Cutaneous Warts

Summary: as many as 85 % of renal transplant patients may suffer from viral warts with a high degree of treatment resistance. promising results of hlac (human lactalbumin complex with lipid) point to a beneficial effect without noticeable side effects of blac (bovine lactalbumin complex with lipid). the aim of first clinical trial with blac is to show proof of concept in treatment of cutaneous wart lesions on hands and/or feet after local administration of blac in two dose groups to immune suppressed, kidney transplanted patients.


Eligibility criteria:
inclusion criteria: * cutaneous warts on ingers and/or palms and/or toes and/or soles of feet * common warts and mosaic warts, diagnosed by an experienced dermatologist * solitary wart lesions or 2 or more lesions per patient * lesions present for more than 6 months * men or women, aged 18 or above * history of kidney transplantation and immune suppressive therapy after transplant * concomitant immune suppressive therapy stable for 6 months prior to randomization * agreement from patient to allow photographs to be taken and used as part of trial data documentation (2 centres) * women of childbearing potential must have negative pregnancy test at screening and must use adequate contraception * ability to comply with requirements of trial * written informed consent exclusion criteria: * verruca plana lesions * suspected allergy to milk verified by serum analysis of ige towards cow milk * breastfeeding * any local medication for any purpose other than wart treatment in target area during 4 weeks prior to randomization and during treatment period * concomitant treatment with other wart therapies two weeks prior to randomization and during trial period * intolerance towards bovine alpha-lactalbumin, oleic acid or any excipient in the formulation * known hiv infection or any current uncontrolled infection * any chronic or acute skin condition susceptible of interfering with evaluation of drug effect in this trial * participation in any investigational trial or use of any investigational drug within 30 days prior to inclusion in this trial * any health problems which according to investigator's clinical judgment will make the patient unsuitable for inclusion in the trial

Keywords: wart cutaneous transplant cutaneous warts in immune suppressed, kidney transplant patients
a study of ribavirin in combination with pegasys (peginterferon alfa-2a (40kd))in patients with chronic hepatitis c

Conditions: Hepatitis C, Chronic

Summary: this single arm study will evaluate the safety and tolerability of ribavirin in combination with pegasys in patients with chronic hepatitis c. patients will receive ribavirin 800mg, or 1000-1200mg po daily, according to hcv genotype and body weight (\ 75kg)in combination with pegasys 180micrograms sc weekly. the anticipated time on study treatment is 3-12 months, and the target sample size is \>500 individuals.


Eligibility criteria:
inclusion criteria: * adult patients, \>=18 years of age; * serological evidence of chronic hepatitis c; * detectable serum hcv-rna; * liver biopsy findings consistent with a diagnosis of chronic hepatitis c. exclusion criteria: * history or other evidence of a medical condition associated with chronic liver disease other than hcv; * co-infection with active hepatitis a or b; * hepatocellular carcinoma; * patients with severe cardiovascular disease whose condition may worsen due to acute anemia.
randomized clinical trial of 8 weeks pulmonary rehabilitation in advanced stage lung cancer patients with copd during cytotoxic chemotherapy

Conditions: COPD; Lung Cancer

Summary: pulmonary rehabilitation might be benificial in advanced lung cancer patients with copd who undergo cytotoxic chemotherapy. we will compare two groups, 8 week pulmonary rehabilitation group and usual care group.


Eligibility criteria:
inclusion criteria: * pathologically proven lung cancer * chronic obstructive pulmonary disease * age \> 20 * ecog 0-1 * cytotoxic chemotherapy exclusion criteria: * other history of cancer within 5 years * other major disease associated with heart, lung, neurology, mental and metabolic disorders * osteolytic bone metastatis to weight bearing site * uncontrolled infection
pdri rates among capd patients at a tertiary university hospital: a 5-year retrospective study

Conditions: Peritoneal Dialysis-related Infection

Summary: peritoneal dialysis-related infection is a complication that leads to peritoneal dialysis catheter removal or patient death. the present study aimed to investigate peritoneal dialysis-related infection rates, causative pathogens, appropriation of antibiotic use, treatment outcomes and trend in antimicrobial resistance of causative pathogens.


Eligibility criteria:
inclusion criteria: 1. patients who were at least 18 years old. 2. patients who were diagnosed with stage 5 chronic kidney disease (egfr \< 15 ml/min/1.73m\^2). 3. patients who were undergoing continuous ambulatory peritoneal dialysis (capd) at capd clinic, phramongkutklao hospital during january 1, 2016 to december 31, 2020. exclusion criteria: 1. patients with incomplete data records that invalid to include in the process of data analysis 2. patients who were not treated and started their first capd at capd clinic, phramongkutklao hospital.

Keywords: peritoneal dialysis-related infection infectious peritonitis exit-site infection tunnel infection infection rate
effectiveness of neck stabilization training program with conventional therapy in management of text neck syndrome

Conditions: Neck Syndrome

Summary: 1. to compare the effectiveness of neck stabilization training program with conventional physical therapy in management of neck pain and disability in individuals with text neck syndrome. 2. to compare the effectiveness of neck stabilization training program with conventional physical therapy in improving muscle strength and range of motion of cervical spine in individuals with text neck syndrome.

the text neck syndrome was described as a compilation of signs and symptoms due to the repetitive load, stress and pain in the body regions including; neck, shoulder joints, shoulder muscles, and thoracic region initiated by the excessive usage of smartphones for the prolonged time. the text neck syndrome is also called as 'turtle neck neck syndrome' or 'anterior head syndrome. neck flexion in forward direction for using any smart phone could directly affects the cervical and upper thoracic spine. it is stated that increased tilt of the head forward to fifteen degrees exaggerate about 13 kgs of mechanical force on the cervical spine. likewise it progresses to 18 kgs at 30 degrees, 23 kgs at 45 degrees and 28 kgs at 60 degrees of forward neck flexion. the pathological consequences caused by incase of not managing the text neck could be alike to occupational overuse disease or repetitive stress and strain pathology.

Eligibility criteria:
inclusion criteria: * gender (both men and women) * age: 18-30 years * participants using smart phones, laptops and tablets with screen time \>3 hours daily, for \>6 months. * patient diagnosed with text neck syndrome * trigger points in cervical muscles (trapezius, levator scapulae and scalene muscles) exclusion criteria: * patient diagnosed with neck pain other than text neck syndrome
acute effects of inspiratory muscle training on peripheral muscle metabolism and autonomic response in copd patients

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: the study will evaluate the acute effects of inspiratory muscle training (imt) on peripheral muscle metabolism and autonomic response in patients with chronic obstructive pulmonary disease (copd). this is a randomized, crossover study, with blinding of the evaluator and the researcher responsible for the statistical analysis. participants will be divided into three groups at different times: tmi- strength (f), tmi to gain inspiratory muscle strength; imt- resistance (r), imt for improving inspiratory muscle resistance; and tmi sham. all participants randomized in the study will participate in the three groups, with a minimum interval of 48 hours between participation in each group. randomization will determine the sequence of participation in the three groups for all participants. for statistical analysis, an intention-to-treat approach will be used, and the groups will be compared using the student's t test for continuous variables or the chi-square test for categorical variables. a split-plot anova with repeated measures will be used for primary outcomes, and analysis of covariance will be conducted to identify differences between groups using baseline scores as covariates. effect sizes and confidence intervals will be calculated using eta squared. it is expected that imt applied at different loads can promote effects on vascular function, peripheral muscle metabolism and the response of the autonomic nervous system in patients with copd, which can greatly contribute to the understanding of the physiological effects of this therapy and support its prescription. as a therapeutic intervention in the rehabilitation of patients with pulmonary diseases.


Eligibility criteria:
inclusion criteria: * patients with copd according to the global initiative for copd (gold, 2023); * aged 40 years or older and under 75 years; * providing both oral and written informed consent. exclusion criteria: * inability to perform the imt protocol and/or functional tests; * presence of psychiatric disorders or cognitive impairments, progressive neurological disorders, cancer, or chronic pain; * cognitive impairment or inability to understand commands. * patients who have experienced any health issue or had a copd exacerbation in the previous month will also be excluded to ensure that the patient's symptoms are stable.

Keywords: copd exercise performance lung diseases.
blood transplantation for patients with hematologic malignancies or bone marrow failure states

Conditions: Leukemia; Non Hodgkin's Lymphoma; Aplastic Anemia

Summary: the purpose of this study is to assess early treatment failure within 100 days and to assess the effect of this regimen on engraftment, gvhd, immune recovery, relapse of malignancy and survival.


Eligibility criteria:
* patients with acute leukemia, lymphoma that failed to respond or relapsed after chemotherapy or cml beyond first chronic phase. * patients with aplastic anemia or myelodysplasia which failed to respond to primary therapy are eligible. * patients with low grade lymphoma or cll will only be eligible if they failed two chemotherapy regimens and have stage iv disease. * patients must be \<age 50 with a related haploidentical donor (phenotypically one, two or three hla a, b and dr antigen mismatched) donor. * patients should have adequate hepatic and renal function with a bilirubin of less than or equal to 1.5mg%, sgpt less than or equal to 3x the upper limits of normal, and creatine less than or equal to 1.5mg%. * patients with serious intercurrent medical illness are not eligible. * patients and their donors must provide written informed consent.

Keywords: lymphoma cml cll aml all mds aa
digital voice analysis in patients with schizophrenia

Conditions: Schizophrenia

Summary: there is a differences in voice frequency of schizophrenic patients compared to patients with other mental diseases and compared to mentally healthy people.


Eligibility criteria:
inclusion criteria: * schizophrenic patients * other mental disease patients * healthy people * people above age 18 exclusion criteria: * none