Kornimate/medical-research-clean huggingface dataset:
a clinical study to investigate the effect of oral neflamapimod on motor recovery after acute ischaemic stroke

Conditions: Moderate to Severe Acute Ischaemic Stroke; Ischaemic Stroke

Summary: the purpose of this interventional study is to determine whether neflamapimod can improve residual physical disability and/or cognitive dysfunction after moderate to severe acute ischaemic stroke.


Eligibility criteria:
inclusion criteria: * male or female participants must be aged 50 years or over at the time of signing the informed consent. * confirmed acute ischaemic stroke in the anterior circulation (middle or anterior cerebral artery) with onset of symptoms between 2 and 7 days prior to screening and evaluation. * national institutes of health stroke scale (nihss) score between 5 and 20 (inclusive) and exhibiting unilateral motor deficit (i.e. motor nihss ≥ 5 on affected side of the body). * fugl-meyer assessment of motor recovery after ischaemic stroke (fmms) total motor components score of 80 or below. * normal or corrected eyesight and auditory abilities, sufficient to perform all aspects of the cognitive and functional assessments. * no history of learning difficulties that may interfere with their ability to complete the cognitive tests. exclusion criteria: * evidence of progressive or unstable stroke or intra-cerebral haemorrhage in the opinion of the investigator * participants needing carotid surgery within 3 months * ongoing major and active psychiatric disorder and/or other concurrent medical condition that, in the opinion of the investigator, might compromise safety and/or compliance with study requirements. * history of alcohol or drug abuse within the previous 2 years. * poorly controlled clinically significant medical illness, such as hypertension (blood pressure \>180 mmhg systolic or 100 mmhg diastolic); myocardial infarction within 6 months; uncompensated congestive heart failure or other significant cardiovascular, pulmonary, renal, liver, infectious disease, immune disorder, or metabolic/endocrine disorders or other disease that would interfere with assessment of drug safety in the opinion of the investigator. * abnormal laboratory tests that, in the investigator's assessment, mean that a participant is not appropriate for participation in this study, including, but not limited to: 1. aspartate aminotransferase (ast) or alanine aminotransferase (alt) \>2.0 × the upper limit of normal (uln), 2. total bilirubin \>1.5 × uln, and/or 3. international normalised ratio (inr) \>1.5 note: participants with gilbert's syndrome can be included with total bilirubin \>1.5 x uln as long as direct bilirubin is ≤ 1.5 x uln)
retrospective analysis of lymphomas and cancers synchronous occurrence in picardy from 2007 to 2012

Conditions: Lymphoma; Cancer

Summary: cancer is the leading cause of death in man and the second leading cause in women with 85,000 and 63,000 deaths, respectively, in 2012. a working group led by holly l. howe, phd, in 2002 defined primary neoplasia such as the occurrence and diagnosis of two or more independent neoplasms of different histology in the same patient. the occurrence of a new cancer has become more frequent in recent years: the prevalence of multiple primary neoplasia (npm) is estimated between 0.73% and 11.7%. according to the french data, the risk of second cancer in people who have already had a first cancer is increased by 36% compared to the general population. several studies have reported an increase in the risk of cancer after treatment of lymphoma but there are currently no studies on the occurrence of lymphoma and cancer of synchronous occurrence. in our department, 19 patients presented cancer and lymphoma synchronously, that is to say 6 months between 2007 and 2012. the main objective is to show that there is an increase in the incidence of cancers in patients diagnosed for lymphoma synchronously. secondary objectives are to describe the clinical and biological characteristics of the patients concerned and to formulate hypotheses on the physiopathological mechanisms involved: peri-tumoral b-cell lymphoproliferation, alteration of the immune system or rearrangement of the bcr. in a second step, the investigator could propose a multicenter epidemiological study using data from the different cancer registries. if results are confirmed in a larger cohort, recommendations could be made.


Eligibility criteria:
inclusion criteria: * being older than 18 * have been diagnosed for hodgkin's or non-hodgkin's lymphoma from 1 january 2007 to 31 december 2012 * diagnostic confirmation either in anatomopathology or in cytology * delay of 6 months maximum between the two neoplasms (synchronic / metachronous distinction) exclusion criteria: * hemopathy other than lymphoma (cll and lymphocytic lymphoma excluded) * diagnosis of lymphoma outside the inclusion period metastases and recurrences were not considered as secondary cancers, but as relapses of the first neoplasia * cutaneous squamous cell carcinomas were not considered secondary cancer because of the absence of available incidence data (francim network)
continuous rhythm monitoring in patients after acute myocardial infarction andpreserved lef ventricle ejection fraction (arrest)

Conditions: Myocardial Infarction

Summary: the trial will inform whether detection of ventricular arrhythmias by means of implantable loop recorder (ilr) can help to predict scd in the large population of survivors of a myocardial infarction with preserved left ventricular function, ef\>40%. this may improve risk stratification in these patients, and can inform on the clinical use of subcutaneous monitors to identify post-infarction populations in need for an intervention to prevent sudden death.


Eligibility criteria:
inclusion criteria * informed consent signed * documented myocardial infarction in the 7days prior to enrolment * age \> 18 yrs * left ventricular ejection fraction \>=40% as assessed by echocardiography within 7 days window after mi. exclusion criteria * subject is unwilling or unable to comply with the study procedures * documented ventricular tachycardia or survived cardiac arrest outside of an acute coronary syndrome * subject has indications for active implanted cardiac medical device (ipg, icd, crt). * contraindications for implantation of a icm - planned cabg procedure
simulation based emergency brex birth management training

Conditions: Birth

Summary: the aim of this study is to determine the effect of simulation-based emergency brex birth management training impact on students' self-confidence and competence.

hypotheses h01; there was no difference between the students'self-confidence and competence of the simulation-based emergency brex birth management training group and students'self-confidence and competence score control group. the study will be carried out in two different groups. the practice will start with meeting the students who apply to the study. after the students are evaluated in terms of eligibility criteria for the research, the students who are eligible will be informed about the research and written informed consent will be obtained from the women who accept. the random distribution of women to the study groups will be carried out using the block randomization method. the following applications will be made to the groups. breech birth management training will be given by the responsible investigator, and then one of the groups separated by randomization will perform emergency breech birth on the second group model using high reality simulator. these trainings will first be in the form of the instructor responsible for the groups demonstrating the application, and then the students will apply it one by one.

Eligibility criteria:
inclusion criteria: - agreeing to participate in the research and obtaining written permission, exclusion criteria: -
rotator cuff tear severity and scapular and rotator cuff muscle activation patterns

Conditions: Rotator Cuff Tears; Rotator Cuff Injuries; Shoulder Pain

Summary: rotator cuff tears are common musculoskeletal injuries that can lead to altered scapular and rotator cuff muscle activation patterns and reduced function. this study aims to investigate the relationship between rotator cuff tear severity and scapular and rotator cuff muscle activation patterns. the primary objective of this study is to determine whether a relationship exists between the severity of rotator cuff tears and the activation patterns of scapular and rotator cuff muscles. secondary objectives include: 1. identifying differences in muscle activation patterns between varying tear sizes. 2. evaluating the potential of these activation patterns as an indicator for the severity of rotator cuff tears. 3. assessing the influence of muscle activation patterns on the functional capacity of the affected shoulder.


Eligibility criteria:
inclusion criteria: * age between 18 and 60 years. * diagnosis of rotator cuff tear confirmed by a qualified orthopedic surgeon. * mri scan showing the size of the tear (small, medium, large, or massive). * ability to provide informed consent and comply with the study protocol. exclusion criteria: * history of shoulder surgery or other shoulder disorders unrelated to rotator cuff tears. * presence of neurological, cardiovascular, or respiratory disorders that could influence muscle activation patterns. * contraindications for semg assessment, such as skin allergies or infections. * inability to perform the required functional tasks due to severe pain or disability.
preventable paediatric trauma - retrospective analysis

Conditions: Pediatric Trauma

Summary: purpose: a retrospective study of all paediatric patients who presented to ziv medical centre with injuries of all systems, major and minor, in order to determine the exact circumstances of the injury, whether this might have been preventable and design a haddon matrix of risk factors for injury to target prevention. hypothesis: injury prevention interventions can be targetted by finding out local causes of paediatric trauma

a trauma registry is already kept in the hospital. it is confidential and data is supplied to the government from this registry. the procedure is to be granted access to the database and access data stored on the mechanism and outcome of paeditric trauma. this data will be stored on the work computer of the principal investigator and will be password protected. methods: identify from the trauma database all patients assessed at ziv medical centre with trauma, consult their medical notes and document the exact injury, the mechanism of injury, the circumstances, whether the child was alone or supervised, the nature and complications of the injury, treatment required and short and long term progress and disability.

Eligibility criteria:
inclusion criteria: * all patients classified as paediatric according to israeli law (up to the age of 18 years). this includes pregnant women and patients presenting with multiple complaints as well as trauma, isolated injuries and polytrauma. exclusion criteria: * patients for whom no history is available.

Keywords: fall burn road traffic crash
family adaptation study following the diagnosis of hypoplastic left heart syndrome in a newborn

Conditions: Hypoplastic Left Heart Syndrome

Summary: survival for one of the most complex forms of congenital heart disease, hypoplastic left heart syndrome (hlhs), has improved dramatically. however, little is known about family stress, coping and outcomes following the diagnosis of hlhs. it is expected that families face emotional, social and financial stressors. health care professionals have a unique opportunity to positively influence how families interpret and adapt to these stressors. the specific aims of the study are to describe perceived stress, and coping skills utilized, in parents of children with hlhs and their impact on family outcomes measured as well-being, adaptation and caregiver/family quality of life, and to describe changes in stress, coping, and adaptation and differences in perceptions of mothers versus fathers of children with hlhs over the first 14 months of life. the resiliency model of family adjustment and adaptation (mccubbin, thompson, \& mccubbin, 1996) is the theoretical framework that guides this research. hypotheses: 1. family perception of stress, and coping skills utilized, will have an impact on family outcomes measured as well-being, adaptation, and caregiver/family quality of life. 2. variables influencing perception of stress and variables influencing family coping will be significant predictors of family adaptation outcomes. 3. perceptions of stress, coping skills utilized, and family adaptation outcomes will improve during the first 14 months of life with an infant with hlhs. 4. mothers and fathers will report different perceptions of stress, coping skills utilized, and family adaptation outcomes during the first 14 months of life with an infant with hlhs.


Eligibility criteria:
inclusion criteria: * parents of all patients diagnosed with complex congenital heart disease requiring hospitalization or intervention during the neonatal period exclusion criteria: * parents unable to speak or read english

Keywords: hypoplastic left heart syndrome family coping complex congenital heart disease
risk adapted therapy of hodgkin lymphoma in upper egypt

Conditions: Pediatric Hodgkin Lymphoma

Summary: determine if radiotherapy could be safely omitted for early hodgkin lymphoma responder patients without compromising outcome

hodgkin's lymphoma accounts for around 40% of all pediatric lymphomas and is the most prevalent cancer among adolescents and young adults. with combinations of chemotherapy and radiation, hodgkin's lymphoma is roughly 80% curable, placing it among the most treatable cancers . since the introduction of combination chemotherapy treatments 20 years ago, the prognosis for children with hodgkin's lymphoma has improved. the treatment is mostly influenced by the stage of the disease at diagnosis, histology, existence of "b"-symptoms, and the presence of bulky disease. nonetheless, 20% of patients do not achieve long-term remission, and around 20% experience treatment-related side effects such as secondary malignancies, infertility, cardiovascular disease, and organ malfunction following chemo-radiation .studies of long-term therapy side effects were made possible by the significant number of survivors. the goal of therapy optimization protocols for pediatric patients with hodgkin's lymphoma is to maintain excellent tumor control while limiting adverse effects and long-term consequences . it is critical to stratify patients based on reliable prognostic factors at presentation and according to the rapidity of response into low-risk (lr) patients who would benefit from less aggressive therapy, avoiding unnecessary toxic side effects, and high-risk (hr) patients who should be subjected to intensified therapy to reduce the rate of treatment failures and relapses .

Eligibility criteria:
inclusion criteria: * previously untreated patients younger than 18 years old with classical hodgkin lymphoma exclusion criteria: * patients aged more than 18 years old. * patients who died early at presentation before starting chemotherapy * diagnosis of nodular lymphocytic predominant hodgkin lymphoma * previous chemotherapy or radiotherapy other (simultaneous) malignancies * severe concomitant diseases (eg, immune deficiency syndrome); or known hiv positive.
a study of the safety of rituxan in patients with rheumatoid arthritis after an inadequate response to previous anti-tnf therapy (sunstone)

Conditions: Rheumatoid Arthritis

Summary: this is an observational study designed to follow patients with ra who have had an inadequate response to one or more anti-tnf therapies and who will receive rituxan. approximately 1000 patients in the united states with ra who have had an inadequate response to anti-tnf therapies and who will receive rituxan therapy will be recruited. there is no protocol mandated treatment assignment in this study. patients will be evaluated and treated according to their physician's standard practice and discretion.


Eligibility criteria:
inclusion criteria: * no prior use of rituxan (except if received within 8 weeks of screening) * signed informed consent form * age ≥ 18 years * diagnosis of ra * inadequate response to one or more anti-tnf therapies exclusion criteria: * have known hypersensitivity to any component of a humanized or murine monoclonal antibody

Keywords: rituximab ra sunstone anti-tnf rituxan
substitution of the normal levels of iron and hemoglobin in pregnant women with iron supplement

Conditions: Prevention of Anemia

Summary: the purpose of the study is to investigate the effectiveness of iron in the treatment of iron deficiency in pregnant 2nd and 3rd quarter. every 30 days the investigators measure the hemoglobin, hematocrit and iron in serum and assess the course of treatment.

the purpose of the study is to investigate the effectiveness of iron in the treatment of iron deficiency in pregnant 2nd and 3rd quarter. every 30 days the investigators measure the hemoglobin, hematocrit and iron in serum and assess the course of treatment

Eligibility criteria:
inclusion criteria: 1. age more or equal of 18 years 2. registration consent 3. have complete 12h week of pregnancy 4. hemoglobin levels \<10,5 ptl 5. hematocrit \< 32 % exclusion criteria: 1. age \<18 years 2. absent registration consent 3. step of pregnancy less than 12 weeks 4. coadministration formulations iron oral or parenterally 5. background of liver kirrosis 6. background of aimosidirosis 7. background acquired or chronic aimatochromatosis 8. aplastic , hemolytic anemia and chronic diseases 9. chronic pancreatitis 10. subjective renal or/and liver disease 11. hypothyroidism or yperthyreoeidismos
project voices: vocal optimization in children elevating the spectrum

Conditions: Autism

Summary: thirty percent of children with autism barely talk or do not talk at all despite years of intervention. this study aims to address this important and long-standing challenge by developing a novel intervention to increase the quantity and quality of vocalizations (i.e., sounds children make before words) and expressive language in young children with autism (aged 2 to 5 years) with minimal verbal skills. the intervention includes contingent responses to the child's vocalizations and vocal elicitation strategies. we also collect social validity information from parents about how they perceive the novel intervention.


Eligibility criteria:
child participants * inclusion criteria * diagnosed with autism spectrum disorder * aged 2 to 5 years old * use no more than 20 words (spoken, signed, or via augmentative and alternative communication) per parent report * use of \< 5 different words during a 15-min communication sample * use of at least one consonant (observed or reported) * primary language of english * exclusion criteria * uncorrected visual or hearing impairment * evidence of severe motor impairment caregiver participants • inclusion criteria * have a child enrolled in the study (one caregiver per child participant is enrolled.) * sufficient english skills to complete surveys

Keywords: autism language vocalizations children
use of wii fit (tm) to increase compliance with home exercises in treating patellofemoral syndrome

Conditions: Patellofemoral Syndrome; Patellofemoral Pain Syndrome; Anterior Knee Pain Syndrome

Summary: to determine the utility of the wii fit tm interactive video game program in patellofemoral symptom resolution, development of increased muscle strength and flexibility as a result of increased compliance with home exercises in adolescent females with patellofemoral syndrome.

patellofemoral syndrome (pfs) is a very common diagnosis amongst adolescents and young adults. symptoms can be chronic in nature and interfere with sporting activity and activities of daily living. current treatment consists of home exercises to increase muscular strength and flexibility. adolescents are known to have poor compliance with treatments for chronic illnesses. there is a paucity of published literature surrounding the wii tm interactive video game. there has been one published report of the use of wii fit tm in rehabilitation where participants used the wii fit tm to train proprioception after ankle injury. individuals that participated in the wii fit tm group found improvement in their balance on objective measures as well as increased enjoyment with their treatment plan. one anecdotal report used the wii tm video game in physiotherapy treatments of a college athlete and found a dramatic increase in attendance compliance after introduction of the video game. this randomized controlled study will determine if using the wii fit tm for home exercise completion will increase compliance and subsequently improve symptoms related to patellofemoral syndrome in adolescent females.

Eligibility criteria:
inclusion criteria: * female between ages of 11 and 17 years of age * a diagnosis of patellofemoral syndrome with one or more of the following symptoms: anterior knee pain, positive theater sign, stairs provoking knee pain. * no physiotherapy or regular, structured home exercise program is being followed * parental/guardian consent to participate * patient assent to participate exclusion criteria: * patients participating in physiotherapy at the time of initial assessment or have had physiotherapy in the last 6 months for patellofemoral syndrome * patients performing regular home exercise program prescribed by physician, physiotherapist, or other allied health professional for patellofemoral syndrome at time of initial assessment * patients who have additional knee pathology (e.g. acute patellar dislocation; acute internal knee derangement (i.e. meniscal, ligament injury); osteochondritis dissecans; severe apophysitis or tendinitis) that could interfere with rehabilitation exercises due to pain or instability from these conditions * individuals with history of knee surgery * individuals that have a wii fit tm video game at home * individuals for whom consent and assent is not obtained

Keywords: anterior knee pain adolescents female interactive video games patellofemoral syndrome treatment compliance home exercises