Kornimate/medical-research-clean huggingface dataset:
digital self-efficacy training to bridge waiting times for psychotherapy

Conditions: Psychiatric Disorder; Waiting for Psychotherapy

Summary: the main aim of this project is to improve waiting periods for specialised psychotherapy. we will apply a brief, smartphone-based self-efficacy training to patients with psychiatric disorders waiting for specialised psychotherapy. additionally, we will use ecological momentary assessment (ema) to assess mood, social contacts, and other parameters daily. we will investigate whether the training can improve self-efficacy and related constructs and if it can help reduce stress and waitlist drop-outs during waiting periods. additionally, we will investigate if the self-efficacy training has a positive effect on motivation and therapeutical relationship regarding the subsequent therapy. after a screening for eligibility, participants will be randomly assigned to intervention and control group. at baseline, participants attend a laboratory session where they are assessed for current psychiatric disorders and further relevant psychological variables. they will then either participate in the digital self-efficacy training combined with ema (intervention group) or in ema only (control group). both will be conducted via a smartphone app. subsequently, participants will be asked to fill in post questionnaires at three different time points: after having finished app usage, one month later, and after the beginning of the subsequent psychotherapy.


Eligibility criteria:
inclusion criteria: * psychiatric disorder * age 18-65 * waiting for psychiatric assessment/treatment (being on waitlist) * sufficient knowledge of the german language * smartphone user * internet access via smartphone * internet access at home (laptop, tablet, or computer) exclusion criteria: * current intense psychotherapy * acute suicidality * acute psychotic symptoms * substance addiction
synthetic generation of hematological data over federated computing frameworks: scd use case

Conditions: Sickle Cell Disease

Summary: haematological diseases (hds) are a large group of disorders resulting from quantitative or qualitative abnormalities of blood cells, lymphoid organs and coagulation factors. despite most of them (\~74%) are rare, the overall number of hd affected patients worldwide is important, placing a considerable economic burden on healthcare systems and societies. despite the existence of several collaborative research groups at national and eu level, current clinical approaches are often ineffective, particularly for rarest conditions, due to the relatively low number of patients per disease and the high number of unconnected clinical entities. synthema aims to establish a cross-border data hub where to develop and validate innovative ai-based techniques for clinical data anonymisation and synthetic data generation (sdg), to tackle the scarcity and fragmentation of data and widen the basis for gdpr-compliant research in rare hematological disorders (rhd). the project will focus on one representative rhd use case: sickle-cell disease (scd).

synthema will develop a federated learning (fl) infrastructure, equipped with secure multiparty computation (smpc) and differential privacy (df) protocols, connecting clinical centres bringing standardised, interoperable multimodal datasets and computing centres from academia and sme. this framework will be utilised to train the developed algorithms and perform smpc-based global model aggregation in a privacy-preserving fashion. the resulting data will be validated for their clinical value, statistical utility and residual privacy risks. the project will develop legal and ethical frameworks to guarantee privacy by-design in the collection and processing of health-related personal data and attain an ethics-wise algorithm co-creation. project outcomes, including pipelines, standards and data, will be made openly available to stakeholders in the healthcare, academia and industry field, and contribute to existing rare disease registries

Eligibility criteria:
inclusion criteria: * scd patients (any genotype). * older than 1 year old exclusion criteria: * younger than 1 year old * post hsct patients
machine learning prediction of multiple infections in elderly surgical patients

Conditions: Postoperative Infection; Geriatrics; Prediction

Summary: utilizing machine learning techniques, investigators developed the geriatric infection assessment model, leveraging domestic databases to predict multiple postoperative infections in elderly patients. the model addresses the current gap in predictive tools tailored for elderly surgical patients in china, offering insights into both overall and specific infection risks.

backgrounds: postoperative infections are a leading cause of adverse perioperative outcomes, particularly for elderly patients. given the varied diagnostic presentations of infection, there is a significant gap in the use of predictive tools to identify those at high risk of developing such complications. objective: investigators aimed at developing machine learning models to predict various postoperative infection risks in elderly patients, facilitating early detection and intervention. methods: a retrospective analysis was conducted on 42,540 elderly patients who underwent non-cardiac surgery at the first medical center of the chinese pla general hospital between january 2012 and august 2018, forming the training set. from this, a 30% subset was randomly designated as the test set. the models incorporated 51 variables including key infection-related factors. three machine learning techniques-logistic regression (lr), random forest (rf), and gradient boosting machines (gbm)-were utilized to develop predictive models for overall and specific postoperative infections, categorized according to the european perioperative clinical outcome (epco) definitions. model performance was gauged by metrics such as the area under the receiver operating characteristic (roc) curve (auc), accuracy, and precision. to enhance model interpretability, investigators employed the rf model's variable importance (vimp) and shapley additive explanations (shap) algorithm. for a demonstrable prediction of specific infection types, data of randomly selected 5 patients were fed into the model with the resulting probabilities depicted in a radar chart.

Eligibility criteria:
inclusion criteria: 1. age ≥ 65 years; 2. patients undergoing surgeries not involving local anesthesia. exclusion criteria: 1. patients undergoing neurosurgery or cardiac surgery; 2. patients with preoperative infections (including pneumonia, ssis, utis, and bloodstream infections).

Keywords: the elderly postoperative infection machine learning risk model
non invasive neuromodulation for patients with motor control disorders

Conditions: Parkinson Disease

Summary: movement disorders are neurological syndromes leading to excessive movements or to limited control of voluntary and automatic movements. many of these disorders are not life-threatening but represent serious difficulties in carrying out the activities of daily living and reduce patient's independence and quality of life. this project neuromod (neuromodulation for patients with disorders of motor control) proposes the development of a neuromodulation-based platform for the rehabilitation and restoration of motor and cognitive functions of patients suffering from parkinson's disease (pd). our project will focus on the application of a novel neurorehabilitation strategy, its functional and clinical validation, and on the evaluation of the impact of the use of the technologies involved in the musculoskeletal and the nervous system as well as user behavior. parkinson's disease was selected as target pathology since it represents a paradigm of motor disorder diseases. parkinson's disease affects adults and has a very high prevalence and a very high functional impact. in order to achieve this objective, we have defined the following research areas: subproject 1. neuromod: development of a neuromodulation platform composed by a tms system, and an emg (electromyography) and eeg (electroencephalography) system in combination with a system of virtual reality based on immersive glasses. subproject 2. neuromod-pd: development of therapies and evaluation of clinical evidence and motor and cognitive impact of neuromod in the rehabilitation of patients suffering from parkinson's disease impact. subproject 3. neuromod-image: development of neuroimaging techniques to investigate the brain areas affected by the proposed therapies and temporary terms that neural plasticity is induced and evolves in parkinson´s disease.


Eligibility criteria:
inclusion criteria: * idiopathic parkinsons disease * hoehn yahr scale i-iii * no drug changes in the last 90 days * no exclusion criteria exclusion criteria: * dementia (minimental scale score \<25) * dependency (modified rankin scale \> 3) * pregnancy or pregnancy plans * pacemaker * implanted metal devices * cochlear implants * claustrophobia * drug infusion pumps * epilepsy / epileptiform anomalies in electroencephalography (eeg) * known structural alterations in magnetic resonance imaging (mri) * atypical parkinsonism * previous repetitive transcranial magnetic stimulation (rtms) * severe comorbidity (cancer, severe debilitating diseases, etc.)

Keywords: neuromodulation tms nfb
effectiveness of nursing care plans based in nursing diagnoses in metabolic control of type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus; Cardiovascular Risk Factors

Summary: background: nurses in clinical practice implement care to patients with type 2 diabetes mellitus (dm2) in order to maintain normal blood glucose readings, promote weight loss and provide nutrition counseling to improve metabolic and blood pressure control. because many disciplines contribute to patient's health outcomes, it is important to distinguish how nurses contribute to patient care and the achievement of health outcomes and the differences between the use or not the classification of nursing diagnoses, and the nursing interventions classification (nic) in clinical practice settings. methods: prospective observational study with 2-year follow-up to assess the effect of nursing care plans based on scientific methodology (ncpsm) on changing the control parameters in routine clinical practice conditions. settings: 31 primary care centers in northeastern urban area of madrid (spain). subjects: 24,124 dm2 patients (full universe).

the computerized clinical record system (ccr) form for primary care of the madrid health service was used as the data source. ncpsm was identified by clinical records of nanda and nic nursing taxonomies, and were defined as nursing care based on the following three criteria: criterion 1.- a patient's ccr must register valuation data based on marjory gordon "functional pattern" in at least the following areas: * health perception * nutritional-metabolic * activity-exercise. criterion 2.- the problems identified and the proper management of treatment will be described using coded diagnoses with nanda. criterion 3.- the nursing interventions carried out by standardized language will be registered according to the nic taxonomy. eligibility criteria for patients were: older than 30 years of age, with previously diagnosed diabetes (cardinal clinical, plus random blood glucose \>200 mg/dl or oral glucose of \>200 mg/dl at 2 h, twice, or plasma fasting glucose of \>126 mg/dl on two occasions or being diagnosed previously, received specific treatment for diabetes) and exclusion criteria were: gestational diabetes, patients involved in clinical trials, patients with life expectancy of less than one year (according to clinical judgment), homebound patients. the primary outcome was hba1c, lipid levels, blood pressure, and bmi after 24 and 48 months of follow-up.

Eligibility criteria:
inclusion criteria: * older than 30 years of age, * with previously diagnosed diabetes (cardinal clinical, plus random blood glucose \> 200 mg/dl or oral glucose of \>200 mg/dl at 2 h, twice, or plasma fasting glucose of \>126 mg/dl on two occasions or being diagnosed previously, received specific treatment for diabetes) exclusion criteria: * gestational diabetes, * patients involved in clinical trials, * patients with life expectancy of less than one year (according to clinical judgment), * homebound patients

Keywords: patient care planning type 2 diabetes mellitus cardiovascular risk factors primary health care spain
pediatric acute and critical care covid-19 registry of asia

Conditions: COVID; Pediatric Disorder

Summary: in december 2019, an outbreak of pneumonia of unknown aetiology was first reported in the city of wuhan, hubei province, people's republic of china. since then, a novel coronavirus, 2019 novel coronavirus (2019-ncov) has emerged as the most likely causative agent. to date, it has evolved into a pandemic involving over a million cases and thousands of deaths have been identified, including a high burden in countries like italy, spain, united kingdom and the united states. this study aims to investigate the clinical epidemiology of 2019-novel coronavirus (2019-ncov) pandemic in asia.

a retrospective/prospective outbreak study of all suspect cases admitted to hospital since the beginning of the pandemic (december 2019). clinical and epidemiological information will be extracted from medical databases for analysis.

Eligibility criteria:
inclusion criteria: * covid-19 suspected cases (by whatever definition) * covid-19 confirmed cases (based on pcr or serum specific igm and igg antibody of novel coronavirus; serum specific igg of novel coronavirus from negative to positive or 4 times higher in convalescence than in acute phase) * \</=21years of age exclusion criteria: * covid-19 suspected cases should not be sarscov-2
from intention to action:scoring your college goals

Conditions: Depression; Anxiety

Summary: the current study aims to prevent the developmental of mental health symptoms in first-year college students through providing a workshop aimed at preparing students for the academic, social, and personal challenges associated with typical college experiences. specifically, the study hypothesizes that first-year student students who participate in a workshop on college readiness will report fewer symptoms of depression and anxiety, higher levels of self-esteem, and better academic performance compared to a similar group of students who do not receive the intervention (the control group). students in the intervention group will participate in a one-time, two-hour workshop that discusses expectations about college, setting goals that are aligned with one's values, predicting barriers to achieving these goals, and how to overcome these obstacles. the workshop will provide students with external resources (both on and off campus) for obtaining additional support to address barriers that arise during their college experiences. students will complete questionnaires about symptoms of depression, anxiety, and their ability to cope with stress before the workshop, after the workshop, and at the end of their first semester. at the end of the fall 2021 semester, students will be asked to share information about their grade point average (gpa) and academic status. the investigators predict that at the end of the semester, those students who participated in the workshop will report lower levels of depression, anxiety and stress, higher levels of self-esteem, and a higher gpa compared to students who did not receive the intervention. students who participated in the workshop will also be more likely to continue (enrolled in the spring 2022 semester) compared to controls.


Eligibility criteria:
inclusion criteria: * first-year, first semester freshman enrolled in psychology 100 courses at cuny college of staten island. exclusion criteria: * under 18 years old * violation of inclusion criteria

Keywords: depression anxiety college mental health mental health prevention
a study to evaluate the photoallergic potential of pep005 (ingenol mebutate) gel, 0.01% in healthy volunteers

Conditions: Actinic Keratosis

Summary: this phase 1 study is designed to determine the photoallergic potential of pep005 gel, 0.01% and it's vehicle on normal skin.


Eligibility criteria:
inclusion criteria: * are healthy males or females; * in the case of females of childbearing potential, are using an acceptable form of birth control and provide a negative urine pregnancy test; * read, understand and provide signed informed consent. exclusion criteria: * are not willing to refrain from using topical/systemic analgesics within 72 hours prior to and during the study; * are using systemic/locally-acting medications during the study and within 2 weeks prior to the beginning of the study; * are using systemic/locally-acting anti-inflammatories during the study and within 72 hours prior to the beginning of the study; * have participated in any clinical testing of an investigational drug within 28 days or any clinical patch application within 14 days prior to enrollment or are currently participating in any clinical testing.

Keywords: peplin pep005
systematic search for primary immunodeficiency in adults with infections

Conditions: Complement Deficiency; Antibody Deficiency; Chronic Sinus Infection; Meningitis, Bacterial; Pneumonia, Bacterial; Otitis Media; Streptococcal Infection; Neisseria Infections; Haemophilus Influenza; Pneumococcal Infections

Summary: antibody deficiencies and complement deficiencies are the most frequent primary immunodeficiencies (pids) in adults, and are associated with greatly increased susceptibility to recurrent and/or severe bacterial infections - especially upper and lower respiratory tract infections and meningitis. the literature data suggest that pids are under-diagnosed in adults. the current european and us guidelines advocate screening adults for pids if they present recurrent benign especially upper and lower respiratory tract infections, or if they have experienced at least two severe bacterial infections and/or have a recurrent need for intravenous antibiotics. the objective of the demonstrate the interest of pids screening in adult patients who present such recurrent infections and/or after the first severe bacterial infection, especially when the patients do not present with known, etiologically relevant comorbidities.


Eligibility criteria:
inclusion criteria: * 18-65 yrs old patients * ≥ 2 bacterial upper or lower respiratory tract infections/years, for at least 2 years, or * ≥ 1 severe bacterial upper or lower respiratory tract infection requiring hospitalization and iv antibiotics, or * ≥ 1 invasive infection (meningitis, bacteriemia, arthritis) due to streptococcus pneumoniae, group a streptococcus, haemophilus influenzae, neisseria meningitidis or neisseria gonorrhoeae exclusion criteria: * concomitant, systemic comorbidity that predisposes to infection (solid or hematological cancer, diabetes mellitus, severe alcohol or intravenous drug abuse, chronic liver or kidney failure, human immunodeficiency virus infection, anatomic or functional asplenia, drug-induced 1 neutropenia, or solid organ or hematopoietic stem cell transplantation). * the presence of a local predisposing factor: cigarette smoking (\> 5 pack-year and/or 5 cigarettes/day), underlying infection (tuberculosis, influenza...), chronic obstructive pulmonary disease, cystic fibrosis or bronchiectasis for pulmonary infections; cerebrospinal leak or preceding upper respiratory tract (urt) infections for non-meningococcal meningitis; oral, dental or skin condition for gas infections * use of corticosteroids, non-steroidal anti-inflammatory drugs, immunosuppressants or cytotoxic chemotherapeutics * pid diagnosed before the infectious episode in question. * current or recent pregnancy * hospital-acquired infection (including infections of prostheses).
osteoporosis and haemophilia

Conditions: Osteoporosis; Haemophilia; Bone Mass

Summary: the aim of this study is to evaluate the prevalence of osteoporosis in adult patients with haemophilia.

the aim of this study is to evaluate the prevalence of osteoporosis in adult patients with haemophilia. subsequently, the ascertained prevalence of osteoporosis in patients with haemophilia will be compared to the latest published data of osteoporosis in germany. furthermore, the impact of severity of haemophilia, comorbidities as well as the role of both physical activity and individual joint condition as influencing factors on the presence of osteoporosis will be analysed by this study.

Eligibility criteria:
inclusion criteria: * adult patients (≥ 18 years of age) suffering from mild (fviii or ix \>5 %), moderate (fviii or ix 1-5 %) or severe (fviii or ix \<1 %) haemophilia a or b * submitted written consent to participate in the study exclusion criteria: * patients suffering from other bleeding diseases * pwh without written consent * pwh \< 18 years of age * secondary osteoporosis
electrophysiologic study of perioperative monitoring of the recurrent laryngeal nerve: impaired vocal cord movement after thyroidectomy

Conditions: Recurrent Laryngeal Nerve

Summary: paralysis of the recurrent (or inferior) laryngeal nerve (rln or iln) is one of the most common and most serious complications of thyroid surgery. neuromonitoring of the inferior laryngeal nerve (iln or recurrent) is a technique currently used during thyroidectomy to locate iln during dissection. detector electrodes are placed in contact with vocal muscle which is stimulated electrically at the location of iln, producing an acoustic and visual signal. this is a basic electromyographic technique whose diagnostic and prognostic potential for the entire neuromuscular system has not yet been fully explored. the study of action potentials generated by the stimulation-detection of nerves iln and vagal nerves at the beginning and end of dissection, notably the decrease in amplitude, could allow a diagnosis during the course of surgery making it possible to diagnose lesions of the nerve and guide the surgeon in his surgical decisions, thus avoiding the risk of bilateral recurrent paralysis. it could also enable the surgeon to give a prognosis for functional recovery.


Eligibility criteria:
inclusion criteria: * patients undergoing a total thyroidectomy or a thyroid lobectomy exclusion criteria: * history of mobility disorder of the vocal cords

Keywords: thyroidectomy electrophysiologic vocal cord movement
correlation between vitamin d and b regulatory cell in pregnancy

Conditions: Labor, Premature

Summary: during pregnancy , the maternal immune system is always confronted with fetal alloantigens. the immunological mechanisms that prevent the rejection of the fetus are still not under understood.

during pregnancy , the maternal immune system is always confronted with fetal alloantigens. the immunological mechanisms that prevent the rejection of the fetus are still not under understood.the fetus is normally accepted by the maternal immune system despite despite the expression of paternal alloantigens. normally, the fetus grows and develops very well with ongoing pregnancy. b regulatory cells are increased in pregnant women compared to non-pregnant women.

Eligibility criteria:
inclusion criteria: * healthy female according to the required groups exclusion criteria: * patient with infectious disease , tuberculosis ,tumor ,hematologic disease,metabolic bone disease or any other connective tissue diseases were excluded. * patient with viral hepatitis. * serological evidence of hiv infection.