Kornimate/medical-research-clean huggingface dataset:
band ligation versus transjugular intrahepatic portosystemic stent shunt (tips) in cirrhotics with recurrent variceal bleeding non responding to medical therapy

Conditions: Gastrointestinal Hemorrhage; Variceal Bleeding; Cirrhosis; Encephalopathy

Summary: patients with liver cirrhoses and recent history of variceal bleeding, with hvpg documented non response to medical therapy with non selective beta blockers +/- mononitrates or variceal rebleeding during adequate medical therapy will be randomized to undergo either multi-session endoscopic multi-band ligation and continuation of medication or tips placement. best treatment for this group of cirrhotic patients is not known so far.

reduction of portal pressure are with oral intake of non selective beta blockers, often combined with mononitrates are the method of choice in secondary prophylaxis of esophageal variceal bleeding. however, studies have shown that this therapy is effective only in 20-50% of the patients, documented by a significant drop of the portal pressure with hepatic venous pressure (hvpg) measurements. the best method for secondary prevention in this high risk patient cohort is not known so far. in this randomized controlled study we hypothesise, that a group of 20 vs 20 patients is large enough to discriminate efficacy of prevention of rebleeding in patients receiving tips implantation or endoscopic band ligation in patients non responding to medical therapy as secondary prophylaxis of esophageal variceal bleeding.

Eligibility criteria:
inclusion criteria: * liver cirrhosis * bleeding from esophageal varices within the last 6 months * sufficient medical therapy (at least 80 mg propranolol per day) * signed written informed consent exclusion criteria: * bleeding of gastric varices * portal vein thrombosis * insufficient medical therapy (less than 80 mg propranolol per day) * exclusion criteria for tips/band ligation (anatomy, impaired coagulation parameters, severe encephalopathy, severe liver failure (bilirubin \> 10 mg/dl)) congestive heart failure, pulmonary hypertension, polycystic liver disease, presence or suspicion of active systemic, biliary or ascitic fluid infection, known cavernous portal vein occlusion * budd chiari syndrome

Keywords: variceal bleeding cirrhosis encephalopathy endoscopic band ligation tips
colonic duplication; two cases report and review of literature

Conditions: Colonic Diseases

Summary: duplicated colon appendix are infrequent detected during surgical exploration. for diagnosed cases, excision of the duplicated part is indispensable, due to risk of malignancy.

alimentary tract duplication represents(atd) 0.2% of all pediatric congenital malformations which affect all gastrointestinal tracts (git) from the mouth to the anus. atd more common in with no familial or racial predilection. the ileum is the most common site (30%-35%) and the colon is the least common site (7%-20%). the transverse colon is the most common site for colonic duplication. the duplicated part of git maybe in the mesenteric or anti-mesenteric side. it may has same vascular supply and mesentry or not(reported only in small bowel).. communication between the anomalous and actual enteric lumens may or may not be present. here in, two cases of colonic and anal duplication add to the knowledge with review of literature of duplicated colon in children.

Eligibility criteria:
inclusion criteria: 1. pediatric patients till age of 18 years old 2. all patients diagnosed with duplicated colon with or without symptoms 3. patients with duplicated colon and other associated colorectal anomalies exclusion criteria: 1. patients \> 18 years with duplicated colon 2. all patients with duplication cyst
effect of remifentanil on postoperative cognition function in patients undergoing major abdominal surgery

Conditions: Patients Undergoing Major Abdominal Surgery; Postoperative Confusion

Summary: the purpose of this study is to investigate the effects of two different analgesic methods (fentanyl vs remifentanil) during major abdominal surgery on postoperative cognitive status of patients.

the purpose of this study is to investigate the effects of two different analgesic methods (fentanyl vs remifentanil) during major abdominal surgery on postoperative cognitive status of patients. in particular, whether there is a correlation between type of anesthesia and the appearance of postoperative cognitive disorder (pocd), including type of anesthesia and levels of pro and anti inflammatory cytokines and investigate whether there is an association between presence or absence of pocd and cytokines levels

Eligibility criteria:
inclusion criteria: * age over 60 years * patients undergoing major abdominal surgery, in general anesthesia * asa class status i-iii exclusion criteria: * history of allergy to drugs used in the study * mini-mental state examination (mmse) value \< 26 * expected duration of anesthesia less than 1 hour and more than 4 hours * presence of a cognitive disorder severity of overt such as to prevent collaboration of the patient * presence of severe electrolyte disturbances or not controlled bool glucose levels * history of pain or cerebral vascular disease on the basis of significant carotid or cerebral artery stenosis, to be verified by scanning eco-color doppler * habitual use of tranquillizers or other drugs affecting the central nervous system * difficulties in the management of the airways, such as to make the necessary changes in anesthesia technique * severe hypotension or hypertension or other vascular disorders, particularly thrombotic events or bleeding during surgery or in the perioperative period * bleeding that requires blood transfusion * medication needs higher or lower than that indicated in the protocol to ensure the depth of hypnosis, indicated by values of bis targets * refusal by the patient

Keywords: major abdominal surgery analgesic method fentanyl remifentanyl postoperative cognitive disorder pro and anti inflammatory cytokines
comparison of two techniques in achieving corneal graft

Conditions: Fuch's Endothelial Dystrophy

Summary: the cornea is a transparent membrane, half a millimeter thick, embedded as a window in front of the eye. when the eye becomes opaque, the eye is not seeing and the only way to restore the visual acuity is to replace the cornea by performing a graft (4000 surgeries per year in france). in half the cases the opacification of the cornea is secondary to dysfunction of the endothelium, cell layer of 15 μm thickness, covering its posterior surface, in charge of regulating the moisture of the corneal thickness and therefore its transparency. while the total corneal transplantation has long been the only intervention for these diseases, it is now possible, from 4-5 years, to replace only the very thin: it is called endothelial transplant or graft lamellar later. this intervention is now experiencing significant success as it reduces very significantly the incidence of complications found after transplantation of total cornea and the visual recovery period. this type of transplant is still difficult to achieve and the best technique is not yet established. indeed, posterior lamellar transplantation of the cornea may be done manually or using an automated device. manual techniques allow the preparation of grafts extremely thin but are difficult to achieve while the automatic techniques, easier, prepare thicker grafts that may be less efficient in visual recovery. the aim of this project is to conduct a prospective study in order to compare these two techniques in terms of postoperative visual recovery and the vitality of the graft during the first year. to date, there is no such study. the department of ophthalmology in the university hospital of rouen is one of the most famous french teams in the field of cornea transplants and receives many patients from different french regions. the recruitment of 40 patients needed to study should be done without great difficulty over a period of 18 months.


Eligibility criteria:
inclusion criteria: * men and woman * 18 years old or more * patient having been informed about the study and having signed a non-opposition to the participation exclusion criteria: * patient presenting an associated eye pathology previously known and able to limit the visual recovery (age-related macular degeneration, diabetic retinopathy, ...) * pregnant women, parturient or breast feeding * refusal to participate in the study

Keywords: fuch's dystrophy corneal graft
health status of < 50 year old patients after surgically implanted biological and mechanical aortic valves: a population-based retrospective analysis (2010-2020)

Conditions: Aortic Valve Disease

Summary: the overall project aim is to study outcomes following aortic valve replacement with either mechanical valves or bioprostheses by retrieving data from the main social security carriers in austria for the years 2010-2020 in under 50 year old patients.

the purpose of this research project is to evaluate mortality (primary outcome) and incidence of heart attack, stroke, reoperation and first diagnosis of heart insufficiency, mace (secondary outcomes) after aortic valve replacement in under 50 year olds. we aim to compare those outcomes between mechanical valves and bioprostheses. data will be retrieved from the main social security carriers in austria (covering 98% of its population) from 2010-2020.

Eligibility criteria:
inclusion criteria: * isolated surgical aortic valve replacement in austria exclusion criteria: * below 18 years of age * above 50 years of age * concomitant heart surgery
diabetes and psoriasis

Conditions: Diabetes; Psoriasis

Summary: patients with psoriasis will be evaluated. the investigators will collect personal history, concomitant diseases and in particular the presence of type 2 diabetes mellitus, impaired fasting glucose and impaired glucose tollerance. the aim of the study will be to evaluate if there is a correlation among inflammation, insulin-resistance and psoriasis.


Eligibility criteria:
inclusion criteria: * patients with psoriasis exclusion criteria: * na

Keywords: diabetes psoriasis inflammation insulin-resistance
ribavirin to prevent rsv pneumonia in bone marrow transplant patients

Conditions: Respiratory Syncytial Virus Infections

Summary: the purpose of this study is to test the safety and effectiveness of ribavirin, administered as an aerosol, in preventing progression of upper respiratory tract rsv infection to rsv pneumonia in bone marrow and peripheral blood transplant recipients.

the study enrolls 90 transplant recipients with positive nasal/throat culture specimens for respiratory syncytial virus (rsv) infection. patients are randomized into one of two groups: investigational treatment or standard treatment.

Eligibility criteria:
inclusion criteria: * 2 years of age or older. * are not pregnant or breast-feeding and agree to use a reliable birth control method for the duration of the study. * are a blood or bone marrow transplant recipient. * have evidence of upper respiratory tract infection. * have nasopharyngeal-throat samples positive for rsv. exclusion criteria: * are known to be hiv positive. * have pneumonia. * require a ventilator to breathe. * are pregnant. * are breast-feeding and are unwilling to stop breast-feeding. * are receiving treatment with certain other drugs for rsv.

Keywords: ribavirin rsv
the effect of kristeller maneuver on maternal and neonatal outcome

Conditions: Secons Stage of Labor

Summary: the use of fundal pressure in management of the second stage of labor is controversial. the aim of this study is both to evaluate the effectiveness of fundal pressure in shortening the second stage of labor and to examine the related neonatal and maternal outcomes.

patients will be randomly allocated to two groups by using a computer-generated random number chart: kristeller maneuver intervention (study) group (n=140) and control group (n=140). umbilical artery blood gas will obtained to assess the newborn's acid-base status. the umbilical artery levels of creatinine kinase, creatinine kinase with myocardial specific isoform, aspartate amino transferase, alanine amino transferase, lactate dehydrogenase and lactic acid will be measured. length of episiotomy and length of vagina will be measured at 45 degrees from the midline. each patient's vaginal laceration, cervical laceration, length of episiotomy and vagina before and after delivery and duration of the second stage of labor in minutes will be recorded. neonatal information will include: infant birth weight, apgar scores, babies requiring pediatric help, and admission of neonatal intensive care units.

Eligibility criteria:
inclusion criteria: * pregnants who were administered for delivery and signed informed consent form were included into the study. exclusion criteria: * pregnant who required oxytocin augmentation, multiple gestations, pregnant with medical problems (such as asthma, thyroid, cardiac, liver, kidney disease, preeclampsia and diabetes), pregnant with previous caesarean and pregnant whose estimated fetal weight \ 4000gr were not included into the study.

Keywords: kristeller maneuver; second stage of labor; perineal laceration; obstetrical outcome; neonatal outcome
an open-study to investigate the safety and efficacy of replenine®-vf in haemophilia b subjects undergoing surgery

Conditions: Haemophilia B

Summary: the main objectives of this study were to investigate the safety and efficacy of replenine®-vf administered in appropriate dosage by bolus infusion to prevent bleeding and achieve haemostasis in subjects with haemophilia b undergoing surgery.


Eligibility criteria:
inclusion criteria: * subjects with moderate to severe haemophilia b undergoing major surgery requiring an in-patient stay of generally 5 to 10 days. exclusion criteria: -
efficacity of a rigid ankle foot orthosis for persons with ankle osteoarthritis

Conditions: Ankle Osteoarthritis

Summary: ankle osteoarthritis (aoa) is a typical long-term complication of an ankle injury. pain during walking is the main symptom that limits walking distance. non-surgical treatments could be used to decrease pain. the gold standard treatment for end-stage oa is definitive surgical ankle arthrodesis. the purpose of this study was to assess the effectiveness of a rigid ankle-foot orthosis (r-afo) for walking pain in a population suffering from aoa.

this study used the sced introduction/withdrawal methodology to assess the efficacy of r-afo on pain and walking distance in the 2-minute walk test (2mwt). each patient is his or her own comparator. during phase a, considered as the baseline, the patient performs the 2mwt without r-afo. during phases b, considered as the introduction phases, the patient performs the tests with r-afo. these tests are performed repeatedly and at regular intervals. the time of transition between phases has been randomized to have a minimum of 3 trials per phase. at the end of each test, an visual analogue scale for the pain and the walking distance travelled during the 2mwt were recorded.

Eligibility criteria:
inclusion criteria: * primary or post-traumatic one-sided ankle osteoarthritis (aoa) * able to walk at least two minutes exclusion criteria: * cardiovascular diseases * respiratory diseases that prevent subjects from performing the walking tests * neurologic or orthopaedic diseases which could affect their gait (excluding aoa) * inability to understand study instructions

Keywords: ankle osteoarthritis ankle foot orthosis ankle arthrodesis single case experimental design
effects of task-oriented station training on cognitive levels and hand functions in geriatric residents of nursing homes

Conditions: Cognitive Decline; Motor Function Disorders; Geriatric Health

Summary: this study explores the impact of task-oriented station training on the cognitive levels and hand functions of elderly residents in nursing homes. utilizing methods like tele-rehabilitation, face-to-face sessions, and home-based programs, this research aims to determine the most effective approach for improving the cognitive and manual skills of this population. the hypothesis driving this study is that targeted task-oriented training can significantly improve the cognitive functions and hand dexterity of elderly individuals living in nursing homes, potentially enhancing their quality of life and independence. participants receive different types of interventions-tele-rehabilitation, direct face-to-face training, and guided home programs-to evaluate which modality most effectively supports cognitive and hand function improvements. the study's design is randomized and assesses the outcomes through various established psychological and physical tests. with an aging global population, such strategies are crucial for maintaining the independence and quality of life of our elderly, potentially reducing the need for intensive care solutions and allowing for longer periods of self-sufficiency and well-being. this summary presents the study in a straightforward manner, explaining the purpose, hypothesis, methods, and significance of the research to make it accessible to non-specialist readers.


Eligibility criteria:
\*\*inclusion criteria:\*\* * age 65 years and older. * residency in a nursing home. * able to provide informed consent, either directly or through a legal guardian. * sufficient cognitive function to participate in the intervention, as indicated by a mini-mental state examination (mmse) score of 18 or higher. * physically able to participate in task-oriented activities, with or without assistive devices. * stable medical condition, with no hospitalizations due to acute illness in the last three months prior to the study commencement. \*\*exclusion criteria:\*\* * diagnosed with severe dementia or any cognitive impairment severe enough as per the healthcare provider to interfere with participation in the study. * any medical condition that significantly limits physical activity or requires intensive medical care during the study period, such as unstable cardiovascular disease, severe osteoarthritis, or recent fractures. * participation in any other experimental rehabilitation or drug trials concurrently. * severe sensory deficits that would prevent participation in the tasks (e.g., severe vision or hearing loss not correctable with aids). * life expectancy less than 6 months as estimated by a physician. * significant psychiatric disorders that might impair the ability to comply with study protocols.

Keywords: task-oriented station training cognitive function hand function tele-rehabilitation face-to-face intervention
study to understand efficacy and safety of investigational agent (pf-04937319) compared to approved agent (glimepiride) in patients with diabetes on metformin

Conditions: Diabetes Mellitus, Type 2

Summary: this is a study to understand efficacy and safety of investigational agent (pf-04937319) compared to approved agent (glimepiride) in patients with diabetes on metformin


Eligibility criteria:
inclusion criteria: * age 18-70 yrs, male and females, with t2dm, on metformin alone or in combination with 1 other oral agent exclusion criteria: * subjects with recent cardiovascular events, those with evidence of diabetic complications

Keywords: t2dm pf-04937319 phase 2
title: povidone-soaked sutures versus ordinary sutures for reducing surgical site infection

Conditions: Efficacy Povidone Soaked Suture in Reducing Surgical Site Infection

Summary: to determine efficacy of using 3 minutes povidone-soaked suture in reducing surgical site infection during wound closure in elective surgery.

participant recruitment and randomisation based on eligibility based on consort. patient will get either package a or b which determine whether they are getting povidone-soaked suture or ordinary suture during wound closure. postoperative, follow up on d10 and d30 of patient well being and signs and symptoms of surgical site infection

Eligibility criteria:
inclusion criteria: * age more than 12 years old * clean surgery or clean- contaminated surgery * elective surgery exclusion criteria: * age less than 12 years old * contaminated wound * dirty wound * allergy to povidone-iodine * pregnant * laparoscopic * emergency surgery

Keywords: suture povidone surgical site infection
improving self regulation in children with fetal alcohol syndrome spectrum disorders: a neuroplastic intervention

Conditions: Fetal Alcohol Spectrum Disorders

Summary: this study on children with fetal alcohol spectrum disorder (fasd) aims to (i) characterize their self-regulation deficits, a process important for controlling emotions and behavior, (ii) describe brain structure and function underlying self-regulation, and (iii) determine whether training to improve self-regulation abilities changes brain and behavior. individuals with fasd have a high risk of cognitive and social deficits, which reflect their difficulties in self-regulation and may lead to mental health concerns in adulthood. importantly, early intervention improves long-term outcome. however the full extent of self-regulation problems in fasds is unknown and the underlying neuroanatomy has not been fully described. furthermore, information on how to best treat children with fasds is lacking. thus, the investigators propose three studies with a sample of 8-12 year old children, 40 with fasds and 20 typically developing controls. in study 1, the participants will be evaluated on cognitive and social self-regulation abilities using clinical and experimental tests. in study 2, the participants will undergo a 1-hour mri scanning session to obtain measures of their brain structure and function. in study 3, fasds will be randomly assigned to an immediate or delayed treatment group. the immediate group will undergo 12-weeks of therapy with the alert program for self regulation®. on conclusion of training, all will repeat studies 1 and 2 and following this retest, the delayed treatment group will undergo training. the investigators will evaluate change in cognitive and social behavior and in brain structure and function by comparing performance and neuroimaging findings before and after the intervention. the investigators expect alert training to significantly improve behavior and alter brain regions important for self-regulation. the findings will yield important information for improving self-regulation in fasds and mitigating the development of mental health challenges.


Eligibility criteria:
inclusion criteria: * fasd: diagnosis of fas/pfas or arnd or * healthy child exclusion criteria: * head injury or other neurological abnormality * debilitating or chronic medical condition affecting the nervous system * mri contraindication, such as braces * inability to read * non-english speaking * iq below 80 (typically developing controls only)

Keywords: self-regulation training neuroimaging response inhibition behavioral regulation emotional regulation