Kornimate/medical-research-clean huggingface dataset:
effect of a new interactive device on the motor and functional abilities of children with bilateral cerebral palsy

Conditions: Cerebral Palsy

Summary: recent research has shown that interventions with assistive technologies lead to an improvement in the motor and functional abilities of children with cerebral palsy (cp). reatouch® is a new interactive interface based on motor skill learning principles. its efficiency during intensive motor skill learning interventions has never been tested in children with bilateral cerebral palsy. therefore, the study aims to investigate the efficiency of using a virtual reality tool to provide a motor skill learning intervention in a randomized trial.

recent research has shown that interventions with assistive technologies could lead to an improvement in the motor and functional abilities of children with cerebral palsy (cp). however they usually miss the functional motor skill learning qualities to match the changes observed in high intensity motor skill learning based interventions.reatouch® is a new interactive interface based on motor skill learning principles that could be implemented in intensive interventions. therefore, the study aims to investigate the effects of intensive interventions with or without the interface on the motor and functional abilities of children with bilateral cp.

Eligibility criteria:
inclusion criteria: * diagnosed bilateral cerebral palsy, * macs levels from i to iii, * gmfcs levels from i to iii, * ability to follow instructions and complete testing. exclusion criteria: * orthopedic surgery, botulinum toxin injections or another unusual intervention less than 6 months before or within the study period. * unstable seizure * severe visual or cognitive impairments likely to interfere with intervention or testing session completion

Keywords: motor skill learning intensive therapy selective voluntary motor control cerebral palsy assistive technology therapeutic device
the effects of intra-articular injection of mesenchymal stem cells in knee joint osteoarthritis

Conditions: Osteoarthritis

Summary: osteoarthritis of the knee is one of the most common causes of disability among elderly. as the disease progresses the cartilage become frustrated, surrounding bone react to become thicker and inflammation occurs in subchondral bone seen in t2-weighted mri as increase in signal density. patients are treated initially by pain management. in patients who don't response to first line treatment invasive treatment like total knee replacement is done. the investigators designed this clinical study with the aim of evaluating therapeutic effects of intra-articular injection of bone marrow mesenchymal stem cells (bm-mscs) in patients with severe knee osteoarthritis.

this is single center, randomized, triple blind phase ii clinical study. patients will be divided into two groups of case and control. all subjects will undergo bone marrow aspiration. mesenchymal stem cells will be isolated from bone marrow, cultured and transplanted back to the knee joint. patients of case group will receive cell injection 1 and 4 months after bone marrow aspiration. placebo will be administered in this group 6 months after the first injection. patients of control group will receive placebo 1 and 4 months after bone marrow aspiration. they all receive cell injection 6 months after first placebo injection. follow up visit will occur at 2 and 6 weeks, and 3 and 6 months after the first injection. radiological exams will be performed before and 6 months after the first injection by mri. clinical quantitative assessment will measure joint function by the womac index and pain by the visual analogue scale.

Eligibility criteria:
inclusion criteria: * osteoarthritis diagnosed by mri exclusion criteria: * pregnancy or lactating * positive tests for hiv, hcv, hbv * active neurologic disorder * end organ damage * uncontrolled endocrine disorder

Keywords: knee joint osteoarthritis mesenchymal stem cell
early detection of fabry disease

Conditions: Fabry Disease

Summary: the main aim of this study is early detection of fd using real-world data for the development of advanced natural language processing methods and to develop a predictive algorithm and to measure the performance of the algorithm in identifying participants with fd. this study is about using data from hospital electronic health record database from the last 10 years to describe the ranking of participants with fd using multilevel likelihood ratios and to validate the algorithm using positive controls. no investigational medicinal product or device will be tested in this study. hospital electronic health record data will be analyzed for a period of up to 6 months.


Eligibility criteria:
inclusion criteria: * in-patient or out-patient datasets of the participating hospital in the last 10 years * participants at any age positive controls: a subset of all participant hospital records that includes the participants with confirmed fd.
a study to investigate the pharmacokinetics, safety and tolerability of an intravenous and oral form of a compound in subjects with varying degrees of renal impairment and normal renal function

Conditions: Pneumonia

Summary: this study will evaluate what effect renal dysfunction has on a drug that has an intravenous (cp-70,429) and an oral form (pf-03709270).

to evaluate the pharmacokinetics and safety.

Eligibility criteria:
inclusion criteria: subjects must meet one of the following renal function categories: * normal renal function (clcr \>80 ml/min). * mild renal impairment (clcr \>50 and \<80 ml/min). * moderate renal impairment (clcr \>30 and \<50 ml/min). * severe renal impairment (clcr \<30 ml/min). exclusion criteria: women who are pregnant or nursing or women who are of childbearing potential. history of clinically significant allergies, including seasonal allergies, and especially drug hypersensitivity including known allergies to components of the study drug formulation, penicillin, carbapenems and/or cephalosporin antibiotics (eg, amoxicillin, amoxicillin/clavulanate, ampicillin, cefadroxil, cephalexin, cefaclor and cefixime). subjects should not have evidence of a history of the following: * normal renal function: clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurological or allergic disease. * renal impairment: any clinically significant (hepatic, cardiac or pulmonary or subjects with acute nephritic syndrome) diseases (except diabetes). stable co-morbid disease where it is unlikely that the disease and medication will alter the outcome of the study will be allowed.
the effects of therapeutic recreation activities on aberrant behaviours of individuals with intellectual disabilities

Conditions: Therapeutic Recreation; Intellectual Disability; Recreational Activities; Aberrant Behaviors

Summary: the aim of this study was to determine the effect of therapeutic recreation activities on aberrant behavior of adolescents with intellectual disabilities. the research was carried out at meram melike hatun special education vocational school in konya. the study took place between may 2019 and june 2019. the parents of the participants who participated in the study consisted of the experimental group (n = 16) and the remaining parents (n = 16) formed the control group and the sample group (n = 32). the personal information form which measures demographic characteristics developed by the researchers according to the literature, and the aberrant behavior checklist scale were used. data were analyzed in spss statistics 23 program. according to shapiro wilk test, sample group was not normal. for this reason, non-parametric tests were performed. in descriptive data, the mean, number, percentage will be used; comparative statistics were made according to the assumptions of non-parametric test (wilcoxon test, mann whitney u test). therapeutic recreation activities was applied as total of 16 sessions, consisting of two sessions per week and each session lasting about 1 hour. the program was implemented by researcher.


Eligibility criteria:
inclusion criteria: - exclusion criteria: having a physical disability, having down syndrome
prospective evaluation of the biomechanical properties of the thoracic aorta coupling magnetic resonance imaging and in-vitro elasticity tests in patients with ascending aortic aneurysm

Conditions: Patient with Ascending Aortic Aneurysm with Surgical Indication for Replacement

Summary: the biomechanical properties of the aorta are currently poorly understood. a better understanding would optimize surgical indications and monitoring techniques for patients with thoracic aortic aneurysms.


Eligibility criteria:
inclusion criteria: * person who has given oral consent * patient with ascending aortic aneurysm with surgical indication for replacement * age \> 18 years old * scheduled surgery exclusion criteria: * person not affiliated to the national health insurance system * protected adult * pregnant or breastfeeding woman * mri contraindication * emergency surgical procedure
the study of microglia/macrophages involved dynamic evolution of glioma microenvironment and the function and visualization of targeted molecules of glioma

Conditions: Glioma

Summary: establishment of glioma microenvironment cell dynamic evolution database reveal the mechanism of gim promoting malignant transformation of glioma cells reveal the dynamic regulation process of immune cells in the process of glioma evolution

to collect tissue samples from different stages of glioma evolution and establish a high-quality high-throughput sequencing database of immune microenvironment cells, so as to lay a data foundation for later mining the dialogue mechanism and key targets between immune cells and tumor cells in glioma microenvironment. based on the analysis results of the above database, the key role of key target molecules in the dialogue between gim and glioma cells and the regulation ability of immune cells in the immune microenvironment were confirmed through cell and mouse animal experiments, which laid the foundation for later targeted drug research and development. combined with fluorescence imaging technology, through in vivo imaging of mice, it can provide more intuitive and effective visual verification for the dynamic infiltration process of gim and other immune microenvironment cells in the process of glioma evolution, and provide a new theoretical basis for the visualization research of dynamic regulation of glioma immune microenvironment cells.

Eligibility criteria:
inclusion criteria: * the patients with glioma in the department of neurosurgery of huashan hospital affiliated to fudan university who meet the following three conditions can be enrolled 1. they were 18-80 years old, male and female; 2. the pathological results of frozen section during operation were gliomas (20 cases of who grade ii, ii and iv, respectively); 3. tissue (6 mm \* 6 mm) can be used for cell sorting on the basis of not affecting clinical routine diagnosis; 4. sign informed consent. exclusion criteria: * patients who meet any of the following criteria will not be included in this study: 1. participants in other clinical trials; 2. pregnant women.
product evaluation for the effectiveness of the clearguard™ hd end cap

Conditions: End Stage Renal Disease (ESRD)

Summary: to assess positive blood cultures (pbcs) in hemodialysis central venous catheter (cvc) patients using two fda cleared devices: clearguard hd end caps compared to conventional end caps.


Eligibility criteria:
inclusion criteria: * all patients dialyzing with a central venous catheter exclusion criteria: * known allergy to chlorhexidine
confirm extension - long-term follow-up study of patients treated with agn1 loep

Conditions: Osteoporosis

Summary: the study is designed as a multi-center study within europe in up to 60 patients treated with the agn1 loep kit in confirm. this will be a non-randomized and non-blinded study. the study will collect long-term follow-up data on the safety and clinical performance of agn1 loep. to qualify, subjects must have previously consented, enrolled, and been treated with the agn1 loep kit in confirm (agnovos study pst-eu-101.1). follow-up evaluations will be conducted at 24, 36, 48 and 60 months from the date the subject originally received the agn1 loep treatment. subjects will receive dxa and x-ray imaging at the 24- and 60-month follow-up visits. the 36- and 48-month follow-up evaluations will be conducted by phone. all timepoints will include general health and medical record review.


Eligibility criteria:
inclusion criteria: * subject had previously enrolled in confirm and received agn1 loep treatment. * subject has willingness, ability, and commitment to participate in baseline and follow-up evaluations for the full length of the study. * subject is capable of giving written informed consent to participate in the study. exclusion criteria: * subject was withdrawn from confirm. * subject has severe comorbidity or poor general physical/mental health that, in the opinion of the investigator, will not allow the subject to be a good study candidate.

Keywords: local osteo-enhancement procedure hip fracture/prevention and control calcium phosphate calcium sulphate loep confirm extension
prevention of musculoskeletal injuries in slovenian armed forces

Conditions: Knee Injuries and Disorders; Ankle Injuries and Disorders; Low Back Pain

Summary: physical readiness of military personnel is a cornerstone of any army, as soldiers are expected to meet high physical demands on a daily basis, and soldiers must complete one hour of physical conditioning each day. participation in physical conditioning increases the risk of musculoskeletal injuries, and our 10-year retrospective analysis shows that 5% of soldiers sustain a sports injury during physical conditioning each year, and that ankle and knee injuries have the highest incidence rates of 25% and 20%, respectively. the primary objective of our study is to decrease the rate of ankle and knee injuries by implementing a preventive training program. the study is designed as a prospective randomized controlled trial with two arms (experimental and control).

members of slovenian armed forces - saf (age range 18-51 years) are expected to participate in the study. prior to recruitment the whole project will be explained to soldiers in a form of briefing during which they have the opportunity to ask and have answers to any questions concerning the nature of subsequent research. following that explanation each participant will sign a consent form to voluntarily participate. no compensation will be given or promised for participation in a study that was approved by the ethical board of the faculty of sport in ljubljana (no. 454/2017). at the time of testing all soldiers must be free of acute injuries and should not reported any pain in musculo-skeletal system. prior to the implementation of the preventive program all participants will underwent the set of functional testing that includes countermovement jump (cmj) testing, stork balance test, pull-ups, single leg hamstrings bridge test, and loaded prone plank test - manual. following initial testing a 15-week preventive training program will be implemented in experimental group, while control group will be training as usual. following the intervention final testing will be performed to check for effectiveness of the intervention. after that a follow-up period will start during which injuries will be registered in both groups and later compared between groups (control and experimental) and within (2016-2017 injuries) groups to see if incidence rate of ankle and knee injuries has fallen.

Eligibility criteria:
inclusion criteria: * no major injuries that would require more than 4 weeks to recover upon entry into the study * age \>18 y * finished initial army training
freeze-dried live attenuated measles/rubella combined vaccine (schwarz ff-8 strain/to-336 strain) specified drug-use survey of vaccinees after the second vaccination

Conditions: Measles/Rubella

Summary: the purpose of this survey is to assess the safety of freeze-dried live attenuated measles and rubella combined vaccine (schwarz ff-8 strain/to-336 strain) (freeze-dried live attenuated measles and rubella combined vaccine "takeda") in terms of the occurrence of unknown/known adverse drug reactions and factors that may influence the safety of vaccinees after the second vaccination.

this survey was designed to assess the safety of freeze-dried live attenuated measles and rubella combined vaccine (schwarz ff-8 strain/to-336strain) (freeze-dried live attenuated measles and rubella combined vaccine "takeda") in terms of the occurrence of unknown/known adverse drug reactions and factors that may influence safety after the second vaccination. freeze-dried live attenuated measles and rubella combined vaccine (schwarz ff-8 strain/to-336 strain) is dissolved in 0.7 ml of accompanying reconstitution fluid (water for injection \[japanese pharmacopoeia\]), wherein a 0.5-ml portion is typically administered subcutaneously as a single dose. in addition, freeze-dried live attenuated measles and rubella combined vaccine (schwarz ff-8 strain/to-336 strain) should be used in accordance with the "regulations for vaccination" and the "guidelines for routine vaccination."

Eligibility criteria:
inclusion criteria: - vaccinees who meet both of the following conditions \[1\] and \[2\]: 1. vaccinees who have a prior history of receiving measles and/or rubella vaccination and who received freeze-dried live attenuated measles and rubella combined vaccine "takeda" as the second vaccination 2. vaccinees whose guardians are able to participate in a questionnaire survey on the health status of vaccinees after vaccination with freeze-dried live attenuated measles and rubella combined vaccine "takeda" exclusion criteria: * none

Keywords: pharmacological therapy
distress related to the feeling of loss of dignity in patients with rheumatic diseases

Conditions: Rheumatic Diseases; Dignity; Quality of Life; Distress, Emotional

Summary: rheumatic diseases (rd) are an important group of different clinical entities and specific diseases that affect a significant proportion of the world population. in mexico, the rd have a relevant representation in the adult population. dignity is a construct characterized by the representation of the self, of the self from others' point of view, and of the interaction of the individual with the environment and social context. living with a chronic illness can threaten experiences of dignity for the sick person and their families. various studies have demonstrated the direct impact of the disease on dignity in terms of physical and psychological symptoms and loss of function. some efforts have been made to operationalize the concept of perceived dignity in the context of chronic diseases the perceived dignity of patients and the distress related to the feeling of loss of dignity (drfld) are outcomes that the patient can report and that the doctors can evaluate to be incorporated into the considerations of comprehensive care. both outcomes are closely related, perceived dignity refers to a complex phenomenon, while distress related to the feeling of loss of dignity identifies those patients with a perceived dignity compromise of such magnitude that it generates anguish.

the patient dignity inventory (pdi) is an instrument originally written in english made up of 25 items integrated into 5 factors that include: symptoms, existential anguish, dependency, peace of mind and social support. has a likert-type response system with a 5-point scale, ranging from 1 ''not a problem'' to 5 ''very serious problem"; higher scores indicate greater dignity-related distress. the pdi has been translated and validated into different languages, including validation in spanish. the pdi instrument was validated in mexico by rodríguez-mayoral et al., in 290 cancer patients. it had very good reliability with an alpha of 0.95 and a 4-factor structure that explained 64% of the variance (loss of meaning in life, loss of autonomy, dependency, and social support). the primary objective of the study is the association between the presence of distress related to the feeling of loss of dignity and quality of life in patients with rd

Eligibility criteria:
inclusion criteria: * patients with a rheumatic disease diagnosis according to their primary rheumatologist who agree to participate exclusion criteria: * patients with a not confirmed rheumatic disease
effects of mollii suit in children with non-ambule cerebral palsy

Conditions: Mollii Suit; Cerebral Palsy

Summary: the aim of our study is to examine the effectiveness of the mollii suit application on gross motor function, spasticity, postural control, upper extremity skills, selective motor control, daily living activities, quality of life, pain, sleep, constipation and drooling problems in non-ambulatory individuals with cerebral palsy (cp).

our study includes children diagnosed with spastic type cerebral palsy at gmfcs level 4 or 5 who applied to the developmental physiotherapy and pediatric rehabilitation unit of gazi university faculty of health sciences, department of physiotherapy and rehabilitation. after the patients are separated according to the specified exclusion and inclusion criteria, they will be divided into two groups by simple randomization method. evaluations will be made before and after treatment. in addition to normal neurodevelopmental therapy (ngt) and mollii suit method will be applied 2 days a week. the total duration of treatment will take 8 weeks. groups; the first group will consist of children with cp who will receive neurodevelopmental treatment. the second group will consist of children who will receive the molli suit method in addition to neurodevelopmental treatment.

Eligibility criteria:
inclusion criteria: * gmfcs 4 or 5 with spastic cerebral palsy children * volunteering to participate in the study exclusion criteria: * botulinum toxina injection in the last 3 months * surgical intervention involving the musculoskeletal system in the last 6 months * having an invasive medical pump (baclofen, insulin, etc.)

Keywords: cerebral palsy mollii suit spasticity salivation constipation gross motor function quality of life
the effect of systane ultra lubricant eye drops (fid 112903) on visual performance

Conditions: Dry Eye

Summary: to evaluate the effect of 2 different lubricant eye drops on visual function of patients with dry eye


Eligibility criteria:
inclusion criteria: * documented diagnosis of dry eye * must not have worn contact lenses for 12 hours prior to day 1 exclusion criteria: * age related