Kornimate/medical-research-clean huggingface dataset:
evaluate the role of soleus muscle exercise in glycaemic control in diabetic kidney disease patients

Conditions: Diabetic Kidney Disease

Summary: evaluate the role of soleus muscle exercise in management diabetic kidney disease

management of diabetic kidney disease. to enhance their glycemic control, diabetic patients are advised to perform 150 minutes per week of moderate-to-vigorous aerobic activity diabetic patients with regular physical activity have reduced daily insulin dose with more glycemic control. in addition to glycemic control, it has also been postulated that the addition of brief intervals of high intensity, sprint -type exercise to aerobic exercise can decrease the risk of late nocturnal hypoglycemic episodes marc t. hamilton et al., 2022, reported that the human soleus muscle could raise local oxidative metabolism to high levels for hours without fatigue, during a type of soleus-dominant activity while sitting (soleus push up exercise), even in unfit volunteers. they reported that soleus push up exercise can improve systemic vldl-triglyceride and glucose homeostasis by a large magnitude, e.g., 52% less postprandial glucose excursion (∼50 mg/dl less between ∼1 and 2 h) with 60% less hyperinsulinemia. muscle biopsies revealed there was minimal glycogen use. this can be explained that the soleus doesn't rely completely on intramuscular glycogen, instead, it uses a mixture of fuels from glucose and lipoproteins.

Eligibility criteria:
inclusion criteria: * patients age 18-60 yrs., * patients with diabetic kidney disease, not on dialysis * with stabilized diabetic treatment regimen for 3 months before participating in the study exclusion criteria: * advanced osteoarthritis of lower limb joints * advanced poly neuropathic patients * ckd type v on dialysis * diabetic foot * hemophilia * bleeding tendency * aki * other causes of chronic kidney disease * patients refuse to participate in the study
a study to compare subject comfort during and after injections with the study products and the safety of the non-fda approved product for the correction of nasolabial folds (nlfs)

Conditions: Facial Wrinkles

Summary: the purpose of this research study is to compare subject comfort during and after injection with nadgl and captique® injectable gel, in the nasolabial folds. captique® is an fda-approved product without lidocaine and is manufactured by genzyme biosurgery (ridgefield, nj). nadgl is a new product (not fda approved) with lidocaine and is also manufactured by genzyme biosurgery. we do not know which of these treatments results in less pain during and after injection. the safety of nadgl is also being studied.

45 subjects are planned; a portion of these subjects will have skin of color

Eligibility criteria:
inclusion criteria: * bilateral nasolabial folds with severity score of 3 or 4 on the 6 point scale. exclusion criteria: * pregnant/lactating women * subjects who have an allergy to lidocaine or other amide-type anesthetics
a multi-center, observational safety registry of subjects with idiopathic parkinson's disease previously treated with intraputaminal infusion of liatermin

Conditions: Idiopathic Parkinson's Disease

Summary: the primary purpose of this study is to evaluate clinical and serologic outcomes after the discontinuation of liatermin therapy as assessed by development of new clinical conditions beyond those expected in patients with advancing parkinson's disease. in addition, the development or resolution of anti-r-methugdnf binding and neutralizing antibodies will be monitored.


Eligibility criteria:
inclusion criteria: - subjects must have a diagnosis of bilateral, idiopathic parkinson's disease who have been enrolled and treated with intraputaminal infusion of liatermin in a previous amgen/medtronic-sponsored trial (protocols 20010109 or 20030160) or the bristol open-label study - at time of implant (study 20030168), subjects need to have been 35 to 70 years of age
physical therapy students: well-being

Conditions: Anxiety State; Motivation; Life Stress; Sleep, Inadequate

Summary: this study aims to explore various psychosocial aspects and the potential benefits of respiratory techniques for physical therapy students.

understanding the psychosocial state of academic students has become a primary concern in contemporary educational research and practice. as students go through the challenges of higher education, factors such as motivation, life satisfaction, and happiness play crucial roles in shaping their academic experiences and outcomes. therefore, researchers have increasingly turned their attention to studying these elements in order to gain insight into the overall state of students and inform strategies designed to create positive educational outcomes. the implications of studying motivation, life satisfaction, and happiness among academic students are far-reaching. by gaining a deeper understanding of these psychosocial elements, educators and policymakers can develop interventions and programs designed to cultivate positive learning environments that support students' psychological well-being and academic success. for example, strategies that enhance intrinsic motivation, such as promoting autonomy and providing meaningful learning opportunities, can lead to improved engagement and academic achievement. similarly, initiatives that promote a sense of belonging and social support can improve students' overall life satisfaction and happiness. thus, this study aims to explore various psychosocial aspects and the potential benefits of respiratory techniques for physical therapy students.

Eligibility criteria:
inclusion criteria: students: enrolled in the physical therapy study program (year i, ii and iii) age: \> 18 years ability to understand and follow instructions availability to provide informed consent. exclusion criteria: pre-existing medical conditions: uncontrolled medical conditions (cardiovascular disease, severe respiratory problems) use of psychotropic drugs: drugs that could significantly affect mood, anxiety level, or sleep quality. pregnancy: due to potential physiological changes that could influence the results of the study. inability to comply with study requirements: these could include completing questionnaires and participating in the respiratory techniques program (if part of the intervention group).

Keywords: students physical therapy anxiety motivation happiness breathing techniques
a mobile health intervention to reduce sweet beverage consumption in latino children

Conditions: Child Obesity; Child Development

Summary: sugar-sweetened beverage consumption is a major contributor to childhood obesity, caries, fatty liver disease, and type 2 diabetes. latino children are more likely to consume sugar-sweetened beverages (ssbs) and to suffer from all of the aforementioned conditions. reading out loud to children from birth through age 5 is critical for the promotion of language and early literacy skills. children whose parents read aloud to them are more likely to start school with the skills required for early reading success. this is important as reading proficiency in third grade is the best predictor of high school graduation and career success. latino children are less likely to be read to than non-hispanic white children and at higher risk of entering kindergarten without critical early literacy skills. thus, there is a pressing need for interventions to reduce ssb consumption among latino children as well as interventions that promote reading out loud. primary care is an optimal setting for such interventions. however, multiple demands on providers' time make it difficult to rely on in-person interventions. for this reason, it is critical to test intervention designs that do not rely directly on health care providers and that can be delivered remotely if needed. the investigators have developed two m-health interventions for latino parents, one that promotes optimal beverage consumption patterns and one that promotes reading out loud to children. the purpose of this study is to test the impact of these interventions on child beverage intake patterns and the frequency with which parents read to children.


Eligibility criteria:
inclusion criteria: * parent identifies child as latino/a/x * child age 1 to 5 (12 to 59 months) * parent has a cell phone that can receive text messages * parent speak english or spanish exclusion criteria: • child does not feed by mouth
treatment of uterine fibroids with asoprisnil(j867)

Conditions: Leiomyoma; Menorrhagia; Metrorrhagia

Summary: the objective of this study is to determine the safety and effectiveness of asoprisnil in symptomatic women with abnormal uterine bleeding associated with uterine fibroids.

no medical therapy is currently available for the long-term treatment of abnormal uterine bleeding associated with uterine fibroids in women and many women must resort to surgery for relief. the objective of this study is to determine the safety and efficacy of asoprisnil 10 mg and 25 mg tablets, compared to placebo, administered daily for 12 months to women with abnormal uterine bleeding associated with uterine fibroids, by assessing whether asoprisnil administration prevents surgical and/or invasive intervention in the study population. women, who meet the predefined uterine bleeding criteria for surgical and/or invasive intervention (hysterectomy, myomectomy, uterine artery embolization) who are willing to undergo surgical and/or invasive intervention if the study medication fails, will be enrolled in this study.

Eligibility criteria:
inclusion criteria: * premenopausal women * history of regular menstrual cycles (21-42 days) * diagnosis of uterine fibroid(s) * abnormal vaginal bleeding associated with uterine fibroids * otherwise in good health * agrees to undergo surgery (hysterectomy) or any other invasive procedure if the study medication fails * negative pregnancy test * agrees to double-barrier method of contraception * pap smear with no evidence of malignancy or pre-malignant changes * endometrial biopsy with no significant histological disorder exclusion criteria: * any abnormal lab or procedure result the study-doctor considers important * severe reaction(s) to or are currently using any hormone therapy * history of osteoporosis or other bone disease * previous myomectomy with 1 year and/or previous uterine artery embolization within 6 months * history of polycystic ovary syndrome or prolactinoma * mri shows significant gynecologic disorder * uterine size \> 25 weeks gestation * hemoglobin \< 8 g/dl at day -1

Keywords: symptomatic uterine fibroids excessive uterine bleeding uterine hemorrhage asoprisnil
chorioretinal vascularization and electrophysiological changes after carotid revascularization

Conditions: Carotid Stenosis

Summary: the aim of the study is to evaluate changes in retinal function by means of electro-functional examinations of the retina and to associate them with any changes in chorioretinal vascular density occurring in the ipsilateral eye after carotid revascularization surgery.


Eligibility criteria:
inclusion criteria: * age \>18 years old * carotid stenosis diagnosis with indication to perform carotid endarterectomy * informed consent form signing exclusion criteria: * age \<18 years old * recurrent intraocular inflammation * retinal disease * optic neuropathy, optic nerve drusen, opacity of the dioptric means in the pre- or post-operative period that prevents the acquisition of high-resolution images * unstable fixation * spheric refractive error \> +/- 6 d spheric and/or +/- 3 d cylinder * history of prior ocular surgery * refusal of signing informed consent form
monitoring minimal residual disease in gastric cancer by liquid biopsy study description

Conditions: Gastric Cancer; ctDNA

Summary: this study aims to evaluate the use of next generation sequencing (ngs) to detect circulating tumor dna in gastric cancer patients after gastrectomy

gastric cancer is the fourth most common cancer in vietnam with high mortality rate. patients at early stages undergo radical gastrectomy with curative intent, but the remaining tumor cells, termed as minimal residual disease (mrd), can later cause relapse. conventional methods to monitor mrd such as imaging and blood tests for biomarkers such as cea are not sensitive and specific enough. ctdna has recently emerged as a promising noninvasive marker with high accuracy to monitor mrd and detect relapse in many cancers such as breast and colorectal cancers. however, its application in gastric cancer has not been extensively evaluated. therefore, this study aims to use advanced ngs technologies to detect ctdna in liquid biopsy as a biomarker to monitor mrd after radical gastrectomy.

Eligibility criteria:
inclusion criteria: 1. male or female patients aged 18 years and older 2. histologically proven primary gastric adenocarcinoma before surgery 3. clinical stage is locally advanced ct2-4a any n and m0 4. in initial evaluation, patient can undergo radical gastrectomy and lymphadenectomy 5. no preoperative therapy, including chemotherapy and radiotherapy 6. no known cancer diagnosis within last five years 7. signed informed consent exclusion criteria: 1. gastrectomy cannot be achieved during operation due to metastasis 2. patient fails to follow-up and provide postoperative samples
celecoxib for primary prophylaxis of combat-related heterotopic ossification

Conditions: Ossification, Heterotopic

Summary: hypotheses: h1: celecoxib, when given less than five days after injury will result in a statistical decrease in the incidence and/or severity of radiographically apparent heterotopic ossification when compared to controls. h2a: a biomarker profile will accurately predict which patients in the treatment group will respond to celecoxib prophylaxis for heterotopic ossification. h2b: a biomarker profile will accurately predict which patients in the control group are at highest risk of developing heterotopic ossification

this study is a prospective, randomized, controlled clinical trial.

Eligibility criteria:
inclusion criteria: 1. iss ≥9 (a traumatic trans-tibial amputation is an iss of 9) 2. extremity wound ≥75cm2 requiring operative intervention 3. minimal age of 18 years exclusion criteria: the following co-morbidities will result in exclusion from study: 1. coronary artery disease, 2. diabetes mellitus (iddm or t2dm), 3. peripheral vascular disease, 4. age \>65, 5. connective tissue disorders, 6. immunosuppression, 7. clinically-evident peptic ulcer disease, 8. substantial renal dysfunction (as assessed by a serum creatinine \>1.5 or calculated creatinine clearance of \<50), 9. spine-injured patients who have recently received or are going to receive spinal fusion as determined by the evaluating neurosurgeon or orthopaedic spine surgeon at lrmc, 10. severe penetrating or hemorrhagic traumatic brain injury, 11. endoscopic gastrointestinal interventions, 12. pregnancy or women of childbearing who does not take a pregnancy test and effective method of birth control. 13. known hypersensitivity to celebrex, aspirin, other nsaids, or sulfonamides. 14. history od asthma, urticaria, or allergic-type reactions after taking aspirin or other nsaids. 15. hepatic impairment 16. warfarin 17. lithium 18. drugs known to inhibit cyp2c9 liver enzymes 19. subjects known or suspected to be poor cyp2c9 metabolizers 20. concomitant use with ace inhibitors and angiotension ii antagonists

Keywords: ossification heterotopic ossification
effect of mass deworming on child growth

Conditions: Low Weight for Age in Preschool Children

Summary: the purpose of the study was to determine whether periodical mass deworming improves growth in children below six years of age.

many children in developing countries get slowed growth because of heavy loads of intestinal helminths. quite often treatment is not sought because there may not be any obvious symptoms. slowed growth may manifest as low weight for age or low height for age. the objective of the study was to estimate the effectiveness of the delivery of an anthelmintic drug through a community child health program on the weight gain of preschool aged children. design: this was a cluster randomized controlled trial in 48 parishes in eastern uganda. all 48 parishes were participating in a new program for child health; 24 were randomly assigned to offer to children an additional service of anthelmintic treatment. the intervention was 400 mg of albendazole added to the standard services at child days over a 3 years period. all children were offered the drug and the main outcome measure was weight gain. results: a total of 27,995 children were recruited into the 2 arms of the study with 14,940 in the treatment arm and 13,055 in the control arm. the intervention arm got an increase in weight gain of about 10% (166 grams per child per year (ci: 16-316) above expected weight gain when treatment was taken twice a year and an increase of 5% when treatment was received approximately annually. conclusion: the inclusion of deworming in regularly scheduled health services appears practical and capable of increasing child growth.

Eligibility criteria:
inclusion criteria: * children 1-6 years exclusion criteria: -

Keywords: underweight preschool mass deworming
videoendoscopic drainage of infected pancreatic collections

Conditions: Pancreatitis, Acute Necrotizing

Summary: the vard (videoendoscopic assisted retroperitoneal drainage) approach as treatment for necrotizing pancreatitis proposes an alternative to standard complicated open abdomen treatment methods. this treatment involves making a small incision and looking inside the abdomen with a videoendoscope. a videoendoscope is an instrument with a small camera and light on the end. it also has an extension tool that the surgeon can use to clean out any dead and infected tissue in the abdomen. this approach may reveal a treatment opportunity with faster recovery potential and shorter hospitalizations for patients with necrotizing pancreatitis.


Eligibility criteria:
* pancreatic necrosis or peripancreatic fluid collection following acute pancreatitis noted on ct scan * infected pancreatic necrosis or pancreatic abscess and determined by + fna (gram stain or culture), as defined by the atlanta symposium * not neutropenic or pregnant * no prior necrosectomy * no pancreatic pseudocyst, either sterile or infected

Keywords: infected pancreatic necrosis
safety and efficacy of evolocumab in combination with statin therapy in adults with diabetes and hyperlipidemia or mixed dyslipidemia

Conditions: Diabetes, Hyperlipidemia, Mixed Dyslipidemia

Summary: the primary objective of this study was to evaluate the effect of 12 weeks of subcutaneous evolocumab (amg 145) in combination with statin therapy (atorvastatin) on percent change from baseline in low-density lipoprotein cholesterol (ldl-c) in diabetic adults with hyperlipidemia or mixed dyslipidemia.


Eligibility criteria:
inclusion criteria: * males and females with type 2 diabetes (receiving pharmacologic treatment for at least 6 months or longer) with stable diabetes therapy * lipid-lowering therapy must be unchanged for at least 4 weeks or more * subjects receiving statin therapy at screening must have a fasting ldl-c of greater than or equal to 100 mg/dl * subjects not receiving statin therapy at screening must have a fasting ldl-c of greater than or equal to 130 mg/dl exclusion criteria: * new york heart association (nyha) class iii or iv heart failure * uncontrolled cardiac arrhythmia * uncontrolled hypertension * type 1 diabetes or poorly controlled type 2 diabetes * uncontrolled hypothyroidism or hyperthyroidism.
teicoplanin-based antimicrobial therapy in staphylococcus aureus bone and joint infection: tolerance, efficacy and experience with subcutaneous administration

Conditions: Teicoplanin-based Antimicrobial Therapy; Staphylococcus Aureus; Bone and Joint Infection

Summary: staphylococci represent the first etiologic agents of bone and joint infection (bji), leading glycopeptides use, especially in case of methicillin-resistance or betalactam intolerance. teicoplanin may represent an alternative to vancomycin because of its acceptable bone penetration and possible subcutaneous administration. various studies have shown that teicoplanin pharmacodynamic profile was superior compared to vancomycin regarding bone diffusion. few studies have investigated the use of teicoplanin in bji, particularly through subcutaneous administration. the aim of this study assesses the efficacy and tolerance of teicoplanin in s. aureus bji, especially focusing on subcutaneous use. this study is a retrospective single-center observational cohort study (2001 to 2011) including all consecutive patients managed at our institution receiving teicoplanin as part of s. aureus bji treatment.


Eligibility criteria:
inclusion criteria: - patients with bone and joint infection caused by s. aureus receiving teicoplanin (iv or sc) as part to treat the infection exclusion criteria: - patients with diabetic foot- and decubitus ulcer-related bji

Keywords: bone and joint infection staphylococcus aureus teicoplanin subcutaneous administration
screening for sleep hypoxemia in pulmonary arterial hypertension

Conditions: Sleep Disorders

Summary: in the investigators study, and regarding results of small cohorts in the literature, the investigators hypothesize that hypoxemia is frequent in ipah and cpeph. the investigators will explore these patients with a one night polysomnography and transcutaneous capnography, searching for hypoxemia and hypercapnia and by determining its physiopathologic mechanisms.

pulmonary hypertension (ph) is a rare and severe disease of young adults, characterized by a progressive increase in pulmonary vascular resistances leading to cardiac failure and death. patients with ph are categorized in two major groups: primary ph (pph) wich is idiopathic, and secondary ph associated with many conditions such as chronic pulmonary embolic diseases (cped).increase in vascular resistance in ph is secondary to vasoconstriction and to a proliferative remodeling process of the arterial wall leading to obliteration of the small arterioles. on the other hand, hypoxemia is known to cause similar changes in vascular architecture. also, some small cohorts study in the literature mentioned an increase of sleep hypoxemia prevalence accounting for almost 70% of cases. the mechanisms of this hypoxemia are completely unknown.our study is observational, prospective and transversal, searching for hypoxemic respiratory sleep disorders (hrsd) in pph and in cpeph. included patients will have one night polysomnography (cidelec) with a continuous measurement of transcutaneous pco2.the major objectives are to determine the prevalence of hrsd, their physiopathologic mechanisms and their possible causal factors according to ph history, clinical findings and hemodynamic severity.

Eligibility criteria:
inclusion criteria: * patient aged 18 to 75 years * patient with ipah ot cpeph stable for at least 3 months. stability is defined by the new york heart association classes for dyspnea and the six minutes walking test (6mwt). furthermore, no changes in medical therapy had occured during the last three months. * patients who signed informed consent exclusion criteria: * patients with secondary ph associated with other pathologies outside cpeph ( sclerodermia, systemic lupus erythematous, portal hypertension, chronic hiv infection...) * patients who had a functional and/or a hemodynamic degradation during the last 3 months or a change in pulmonary hypertension treatment * patients with obstructive or restrictive ventilatory disorder with a ventricular ejection fraction \<60% predicted * women without effective contraception * patients with a body mass index above 35 kg/m2 * patient not affiliated to a social security scheme

Keywords: pulmonary arterial hypertension chronic post embolic disease sleep hypoxemia polysomnography sleep apnea periodic respiration