Kornimate/medical-research-clean huggingface dataset:
comparison of culture media for in vitro embryo development

Conditions: Infertility

Summary: the purpose of this study is to collect development and outcome data on human embryos which are cultured in a 2nd generation continuous single culture medium (cscm2) with the objective to demonstrate its performance efficacy in comparison to existing commercially available single culture or continuous embryo culture media.

a multi-center (3 sites and 2 investigators), prospective trial with up to 300 patients. patients will be enrolled from participating sites from the united states. study sites will conduct this study under the oversight of sterling irb. each study site should enroll enough patients to achieve at least 50 evaluable patients that have undergone a treatment cycle using split case sibling embryos in which half of the embryos are cultured in cscm2 and the other half in current cscm (as control). the methods will consist of standard ovarian stimulation protocols at each facility to obtain a sufficient number of mature (mii) oocytes for fertilization by icsi. following fertilization, identified diploid (2pn) zygotes will be evenly divided and randomly allocated to the embryo culture treatment conditions of cscm2 or cscm and cultured according to standard laboratory procedure (incubated in 5-6% co2 in air or low o2 concentrations of 5-6%) to the blastocyst stage (day 5/6 or 7). top quality blastocyst(s) will be transferred and monitored for implantation, pregnancy and ongoing birth. embryo transfers will either occur in a fresh or frozen cycle. the procedures in this study are designed to follow the standard medical care at each study site for women having ivf treatment (the participant will sign a separate consent at your clinic for your ivf procedures). the participants study doctor will explain in detail the procedures participants will undergo at the clinic; this form is only meant to explain the details of the research study. this study does not involve randomization of patient participation or any sham procedures.

Eligibility criteria:
inclusion criteria: * at least 18 years of age in good general physical and mental health. * women undergoing fresh in vitro fertilization treatment using their own eggs which will be fertilized by icsi only * normal uterine cavity, as defined by the program. * normal bmi (\< 35). * normal endocrine workup (including pcos patients). * fresh or frozen blastocyst transfer * at least 4 diploid zygotes showing signs of normal (2pn) fertilisation * willing to have half of their 2pn embryos cultured in cscm and the other half of their 2pn embryos cultured in cscm 2nd generation * willing to comply with study protocol and procedures * willing to provide written informed consent exclusion criteria: * use of donor egg / gestational carrier * couples for whom the male partner requires surgically extracted sperm (testicular or epididymal retrieval) * history of complications related to tolerance to ocp's, gonadotropins, progesterone or estrogen. * a medical condition that is contraindicated to pregnancy or gonadotropin therapy (eg. allergies, immune deficiency, etc.) * history of cancer
magnetic reflexologic insoles for primary dysmenorrhea

Conditions: Primary Dysmenorrhea

Summary: in the study, easy-to-access and easy-to-use reflexologic magnetic insoles were used in women with primary dysmenorrhea who did not want to receive medical treatment; in addition to reducing symptoms such as pain, nausea, dizziness, fainting, vomiting, weakness, constipation/acute gastroenteritis, it is aimed to increase individuals' participation in daily life activities and increase their quality of life by increasing their emotional state.

60 women diagnosed with primary dysmenorrhea through examination by a gynecologist will be included in the study. 60 women will be randomly divided into 2 groups. these groups; reflexologic magnetic insoles sham group: they will use orthopedic insoles.

Eligibility criteria:
inclusion criteria: * having been diagnosed with primary dysmenorrhea * visual analogue scale (vas) value is 3 and above * the patient has cooperation * having regular menstruation exclusion criteria: * getting pregnant during treatment * using analgesic medication * visual analogue scale (vas) value should be between 0-3 * having pain in another part of the body

Keywords: dysmenorrhea reflexology pain foot orthoses
the effect of foot reflexology massage on neuropathic pain

Conditions: Type 2 Diabetes

Summary: this study is conducted to measure the effect of foot reflexology massage on neuropathic pain in diabetic patients.is reflexology foot massage applied to type 2 diabetic patients effective on neuropathic pain?

controlling pain in individuals with diabetes; it is important for the individual to relax, increase the quality of life, reduce complications and shorten the duration of hospital stay. for this reason, the importance of neuropathic pain and its treatment is increasing in terms of public health. in this study, the effect of foot reflexology massage applied to women with type 2 diabetes on neuropathic pain was measured.

Eligibility criteria:
inclusion criteria: 1. those diagnosed with type 2 diabetes, 2. being 18 years or older 3. individuals who do not have any fractures in the extremities, skin diseases, past wound history, open wounds and unilateral or bilateral amputation, tendonitis in the ankle, active foot ulcer and infection. 4. those who volunteer to participate in the study, 5. those who do not have problems with verbal communication, 6. those who have not been diagnosed with any psychiatric disease. 7. those with neuropathic pain of 12 points and above according to the lans score 8. patients receiving duloxetine drug therapy 9. those who are not pregnant 10. patients without peripheral artery disease, deep vein thrombosis and gonatosis will be included in the study. - exclusion criteria: 1. those who did not agree to participate in the study 2. those under 18 years of age 3. individuals with no fractures in the extremities, skin diseases, past wound history, open wounds and unilateral or bilateral amputation, tendonitis in the ankle, active foot ulcers and infections. 4. those who have problems with verbal communication 5. those with neuropathic pain below 12 points according to the lans score 6. patients receiving treatment other than duloxetine drug therapy 7. those who are pregnant 8. those with any psychiatric disorder 9. patients with peripheral artery disease, deep vein thrombosis and gonatosis will not be included in the study.-

Keywords: foot massage reflexology neuropatic pain nursing neuropathy
brief intervention to reduce drinking and intimate partner violence in women

Conditions: Intimate Partner Violence; Substance Use

Summary: the purpose of this study is to examine whether adding a brief alcohol treatment to standard violence intervention programs for women will result in reduced drinking, reduced partner violence perpetration, and reduced partner violence victimization. we hypothesize that, relative to standard care, women receiving the additional brief alcohol intervention will have better alcohol use and partner violence outcomes.


Eligibility criteria:
inclusion criteria: * hazardous drinking * participation in a batterer intervention program

Keywords: intimate partner violence alcohol use substance use
quality of care in relationship to aborted cancer surgery

Conditions: Cancer; Gastrointestinal Cancer

Summary: surgery is often a central curative treatment for gastrointestinal tumors. surgical treatment of diagnosed cancer tumors is decided after a comprehensive assessment of the patient's physical status, radiological assessments and after careful evaluation at the multidisciplinary conference. despite the careful preoperative assessment of patients for curative surgery, the planned operation may unexpectedly need to be canceled. of the patients who were planned for curative resection for pancreatic cancer in 2021 in sweden, 90% received the intended surgery, and 10% of planned surgery was canceled. the reason for this was disseminated cancer or locally advanced disease in which radical resection is considered impossible to carry out. a systematic review of knowledge reveals a significant lack of evidence regarding patient-centered research and aborted cancer surgery. the studies in the project have different study designs and methods, and include focus group interviews with staff, translation and validation of a questionnaire to measure care needs, estimation of supportive care needs and patient experiences. an improved understanding and knowledge of patients' preferences and needs is needed to design interventions that can improve health-related quality of life. this project is dedicated to studying patients undergoing aborted cancer surgery, with the aim of improving the quality of care and meeting patients' care needs.

the overall objective of this research project is to: * describe the patients experiences and assess supportive care needs following aborted cancer gastrointestinal surgery * increase knowledge of the healthcare professionals' experiences of aborted cancer surgery from a multi-professional and continuum of cancer care perspective * increase our clinical knowledge of patient preferences and healthcare professionals' perspective to develop tailored patient-centered interventions with the goal to improve quality of cancer care

Eligibility criteria:
inclusion criteria: * \>18 years * cancer patients with different gastrointestinal cancer diagnosis exclusion criteria: - not able to answer the questionnarie scns-sf34 in swedish.

Keywords: cancer nursing, patient preferences patient-centered care
evaluation of the pravalence of rathke's cleft cyst of children under 15 years

Conditions: Rathke's Cleft Cyst

Summary: the goal of the study was to evaluate the pravalence of rathke's cleft cyst of children under 15 years of age and demonstrate that their prevalence is higher than for patients over 15 years of age, due to their embryonic origin. it is also aimed to describe their aspect on mri and evaluate the interobserver agreement in the detection of rathke's cleft cyst.

rathke's cleft cysts (rcc) are benign cystic lesions in the sellar region and correspond to embryonic remnants of the rathke's pouch. the prevalence of rcc in the literature is higher in adults than in children, but the data for children is limited and outdated. the hypothesis is that the frequency of rcc has been underestimated in children and that it actually decreases with age, especially in adults. the main objective of this descriptive study is to study the prevalence and signal of rcc in children under 15 years of age. 460 encephalic mris of children under 15 years of age comprising at least one sagittal sequence without t1-weighted injection and/or a t2 sagittal sequence adapted to the study of the pituitary gland, were analyzed retrospectively. examination analyses was performed blindly by two radiologists for serous rcc, hypersignal on t2-weighted and isosignal t1-weighted sequences, and mucosal rcc, hyposignal on t2-weighted sequences and hyper or isosignal on t1-weighted sequences. the results were consensually read in case of disagreement on the presence or absence of an rcc. of the 460 patients included, the prevalence of rcc was 3% (14/460). 21% of the rcc cases (3/14) were serous and 79% (11/14) were mucosal. of the 14 patients with rcc, a post-pituitary cyst was also found. the interobserver agreement was strong with a cohen kappa coefficient of 0.85. the prevalence of rcc in children under 15 years of age (3%) is higher than that described in the literature (1.2%) and is close to that of adults (3.9%). rccs are thus intra-sellar lesions of relatively frequent discovery in children, i.e. to identify in order to not erroneously lead to a differential diagnosis including tumors which would lead to a different prognosis, management, and follow-up.

Eligibility criteria:
inclusion criteria: * children aged 15 or under at the time that an mri was performed exploring the sellar region * mri with at least t1 spin echo (se) sagittal slices with a slice thickness of 2.5 or 3 mm with inter-slice spacing of 0.3 mm and t2 se with a slice thickness of 2 mm and inter-slice spacing of 0.2 mm. exclusion criteria: * patients with incomplete mri protocol * patients whose mri images had artifacts (patient movement, presence of dental material) * patients with suspected pituitary pathology due to endocrine symptomatology (growth retardation, puberty delay, diabetes insipidus) that could be attributed to an intrasellar injury were also excluded.
behavioral family therapy and type one diabetes

Conditions: Diabetes Mellitus, Type 1

Summary: behavioral family therapy, specifically focused on insuring support for the primary caregiver of a child with type one diabetes mellitus and healthy family dynamics, may improve the child's glycemic control as measured by hemoglobin a1c level (hba1c).

the success or failure of type 1 diabetes mellitus (t1d) management in children depends not only on access to care, diabetes technologies and diabetes education, but also on the abilities of the patient and his/her family to carry out complex demands. recent data show that family dynamics play a critical role in determining glycemic control in pediatric patients with t1d. the investigators prior work (loomba-albrecht and glaser, unpublished data) suggests that the strongest determinants of glycemic control are factors related to the primary caregiver's involvement in supportive relationships with others, either a spouse or other family members. this provides a potential therapeutic target to improve outcomes for children with t1d.

Eligibility criteria:
inclusion criteria: * age 2 to 17 years * newly diagnosed (within the past 12 weeks) with t1d * seeking care at uc davis exclusion criteria: - families will be excluded if the child has severe underlying psychiatric, behavioral or medical conditions which could independently affect parental marital stress
traditional islamically integrated psychotherapy for muslims with ocd in pakistan

Conditions: Obsessive-Compulsive Disorder

Summary: the current study aims to determine the effectiveness of the first culturally adapted traditional islamically integrated psychotherapy (tiip) for muslims with ocd in pakistan along with the module effectiveness in reducing ocd symptoms with comorbidities like anxiety, depression, stress, thought control, thought-action fusion, and enhancing the spiritual quality of life of participants.


Eligibility criteria:
inclusion criteria: * the client diagnosed with ocd according to dsm-5-tr. * the minimum score on y-bocs is 08 (i.e., indicating moderate level of symptoms) * the age range is from 18 to 40 years * the client has a minimum of eight years of formal education exclusion criteria: * the client is having a comorbid diagnosis of severe psychiatric illness (e.g., psychotic disorders, personality disorder, substance use disorder, neurocognitive disorder) * the client is having a comorbidity of chronic physical illness * the client refused to sign the informed consent form, * the client has experience undergoing manualized faith-based cbt
evaluation of block duration in type 2 diabetes patients

Conditions: Diabetes Type 2

Summary: diabete animal studies demonstrated a longer period recovery after local anesthetic injection (perineural administration). no clinical study demonstrated a prolonged nerve block duration in diabete type 2 patients after peripheral nerve block. the investigators hypothesized that block recovery is delayed in diabetic patients.

for diabetic patients, peripheral nerve block is an interesting alternative to general anesthesia because it provides effective analgesia and may decrease haemodynamic complication. the fear of nerve injury after regional anaesthesia in diabetic patients is a concern that has neither been confirmed nor refuted by current literature. as a matter of fact, diabetic patients with neuropathy may be considered at increased risk because of the possibility for double crush syndrome when a chronic axon lesion related to diabetes is associated with an unexpected distal nerve injury related to regional anaesthesia.

Eligibility criteria:
inclusion criteria: * age (50 80 yrs) with monofilament test 10 g (\> 4/8) exclusion criteria: * refusal of sciatic nerve block, * age \ 80 yr, * american society of anesthesiologists state \> iv, * presence of contraindications to local anaesthesia (known allergy to local anaesthetics, sepsis), * emergency surgery, * patients unlikely to be fully cooperative during the study, * psychiatric disorders, or * those abusing alcohol or drugs, and * participation in another study within the previous 30 days. moreover, patients with preoperative estimated values of creatinine clearance \ 8 % or with type 1 diabetes mellitus (insulin therapy)

Keywords: local anesthetic sciatic diabetes block duration
psychological impairment due to covid-19

Conditions: Psychological Distress; Quality of Life

Summary: hospital staff and emergency personnel are expected to suffer impaired psychological outcomes during a pandemic in terms of quality of life, anxiety, depression or other outcomes. the covid-19 pandemic is a threat for both somatic and psychological health, therefore the impact of the impairment of this event on psychological parameters has to be assessed.

hospital staff and emergency personell are confronted with severe and life-threatening situations, therefore this group is considered to be at risk for impaired psychological health. a pandemic such as the covid-19 endemic is suggested to severely impair the psychological state of this profession, amongst others quality of life, anxiety, depression and other parameters. therefore, it is crucial to assess the impact of impairment due to this global threat on the psychological health of health care providers. we therefore designed this study to evaluate baseline psychological characteristics and to re-assess those values in an interval of 60 days.

Eligibility criteria:
inclusion criteria: hospital staff (doctors and nurses) exclusion criteria: none

Keywords: quality of life psychological distress
autologous micro-fragmented adipose tissue in the treatment of minor amputations of diabetic foot

Conditions: Diabetic Foot

Summary: this is a randomized controlled monocentric study on 114 diabetic patients with the aim of evaluating the efficacy of the lipofilling with lipogems® system in diabetic patients that are candidates for a minor amputation in the foot. in particular, it will be evaluated whether the lipofilling will be able to shorten the healing times and to reduce the number of major amputations, with consequent positive impact on the quality of life. patients will be randomized to the treatment group with lipogems® (local injection of autologous micro-fractured adipose tissue) or to the control group, thus, treatment according to standard clinical practice.

primary objective of this study is the evaluation of the time of the healing of the lesions resulting from minor amputations (digital or forefoot) treated with lipogems® technique. secondary objectives are: 1) assessment of the safety of the lipofilling; 2) evaluation of the intensity of pain (vas); 3) assessment of the skin tropism; 4) calculation of the relapse rate (defined as the occurrence of local infections, dehiscence and suffering of skin flaps that lead to a revision of the amputation stump or amputation at a higher level); 5) evaluation of the time of hospitalization and quality of life (qol).

Eligibility criteria:
inclusion criteria: 1. patients with diabetes (diabetes mellitus type 1 and type 2) of both sexes over the age of 18 years. 2. presence of irreversible gangrene digital or localized at forefoot (with x-ray of the foot negative or positive for osteolytic lesions at phalanges and/or metatarsus). 3. patients with vascular problems absent or resolved (evaluated with eco color doppler and abi (ankle brachial index, that calculates the ratio of the systolic pressure measured at the ankle and the systolic pressure in the arm, both measured in supine position using wave continue doppler. if assessable, it has to be greater than/equal to 0.7) and pressure index finger/arm tbi (toe brachial index, if assessable, it has to be greater than/equal to 0.6) and/or by the determination of the transcutaneous oxygen pressure (tcpo2 that needs to be equal to or greater than 30mmhg). exclusion criteria: 1. oncological treatments ongoing or previous (past 5 years) and/or neoplastic lesions 2. patient under steroid therapy 3. active vascular issues

Keywords: lipogems adipose-derived mesenchymal stem cells lipofilling diabetic foot
the effect of low level laser therapy on neck and shoulder pain

Conditions: Musculoskeletal Pain

Summary: this study is to see if applying red and violet low level laser light to the neck and shoulders can help to reduce pain in the neck and shoulders.

it is the goal of the current study to demonstrate non-inferiority in efficacy of the erchonia® evrl when used in simultaneous dual diode mode (both the red (640 nano-meter (nm)) and violet (405 nm) diodes activated simultaneously) compared to its use with the red diode only activated, for adjunctive use in providing temporary relief of minor chronic neck and shoulder pain of musculoskeletal origin.

Eligibility criteria:
inclusion criteria: * subject presents with one or more of chronic neck or shoulder pain. * subject is diagnosed with of one or more of osteoarthritis, chronic muscle spasms or cervical and thoracic spine sprain strain. * pain is chronic, having persisted for longer than the past 30 days * self-reported pain rating on the 0-100 visual analog scale (vas) of 50 or greater. * willing and able to refrain from consuming any over-the-counter and/or prescription medication(s) and/or herbal supplements intended for the relief of pain and/or inflammation, including muscle relaxants throughout the course of study participation. * willing and able to refrain from engaging in any non-study procedure therapies throughout the course of study participation, including conventional therapies such as physical therapy, occupational therapy and hot or cold packs, as well as alternative therapies such as chiropractic care and acupuncture * 18 years of age or older exclusion criteria: * current active chronic pain disease: such as chronic fatigue syndrome and fibromyalgia * use of analgesics or muscle relaxants within 7 days prior to study procedure administration. * use of systemic corticosteroid therapy (inhaled and topical corticosteroids permitted), narcotics or botulinum toxin (botox®) injection in the neck/shoulder region within 30 days prior to study procedure administration. * active cancer or treatment for cancer within the last 6 months. * unstable cardiac disease, such as recent cardiac arrhythmia, congestive heart failure or myocardial infarction. * prior surgery to the neck/shoulder region. * known herniated disc injury. * active infection, would or other external trauma to the areas to be treated with the laser medical, physical or other contraindications for or sensitivity to light therapy. * serious known mental health illness such as dementia or schizophrenia; psychiatric hospitalization in the past two years. * pregnant or breast feeding. * participation in a research study within the past 30 days.