Kornimate/medical-research-clean huggingface dataset:
haplo-identical hematopoietic stem cell transplantation following reduced-intensity conditioning in children with neuroblastoma

Conditions: Neuroblastoma

Summary: to date, no curative option exists for patients with relapsed or refractory stage iv neuroblastoma after previous autologous stem cell transplantation. our preliminary results of ric allo-hsct (protocol rice) indicate the feasability and low toxicity of allograft in heavily pre-treated children. furthermore ric sct and immunomagnetic cd3/cd19 graft depletion may allow hhct with lower toxicity and faster engraftment. cd3/cd19 depleted grafts not only contain cd34+ stem cells but also graft-facilitating cells, cd34- progenitors, dendritic and natural killer cells which may allow stable engraftment and participate to gvt effect. after haploidentical stem cell transplantation anti tumour activity exerted by donor derived nk cells could be stimulated by nk cells injections. those effects may help to reduce the relapse rate and to impove the outcome of those patients. the investigators prospectively evaluated engraftment and immune reconstitution.

this rice nk protocol is a multicenter study of haplo- hsct using ric with fludarabine (180 mg/m2), busulfan iv (3,2 to 4,8 mg/kg/d), tbi 2 grays and cd3/cd19 graft depletion. a minimum of 8 106 cd34+ cells/kg were infused on day 0. no post grafting immunosuppression was applied if the graft contained \< 2.5 x 104 cd3+ cells/kg. at day 30 and 60 post-graft we perform an donor cd56+ cells injection. the investigators develop this strategy in an european collaboration working on haploidentical stem cell transplantation for childhood refractory and metastatic solid tumors.

Eligibility criteria:
inclusion criteria: * high risk neuroblastoma * hla haplo-identical family donor exclusion criteria: * patient with fast progressive neuroblastoma * lansky \< 60%

Keywords: neuroblastoma - haplo hsct - reduced intensity conditioning - immunotherapy nk
methohexital v propofol as general anesthetic in patients on aceis or arbs

Conditions: Hypotension; Anesthesia

Summary: patient undergoing general anesthesia in elective surgery will be assigned to receive either methohexital or propofol general anesthesia. hypotensive events during the first 15 minutes of induction will be compared between the groups to ascertain which drug is less likely to cause a hypotensive event.

patients taking angiotensin converting-enzyme inhibitors (aceis) or angiotensin receptor blockers (arbs) are susceptible to hypotensive events during general anesthesia. the purpose of this study is to determine if the use of either methohexital or propofol general anesthesias is more likely to result in hypotensive events in these patients during their induction. hemodynamic metrics like blood pressure, mean arterial pressure, and heart rate will be monitored during the induction process, under both drugs, for use as the main metrics, as well as the need for vasopressors in response to patient hypotension.

Eligibility criteria:
inclusion criteria: * treated for at least 6 weeks with aceis or arb * undergoing elective surgery under general endotracheal anesthesia * asa physical class i or ii exclusion criteria: * bmi \>45kg/m\^2 * taking both acei and arb * history of difficult intubation in the past * require rapid sequence induction and intubation * uncontrolled baseline blood pressure (sbp\>180mmhg or dbp \>110 mmhg) at anesthesia preoperative clinic visit * contraindication to the use of propofol or methohexital * significant coronary artery disease * history of systolic heart failure * history of renal failure (creatine level \>2 mg/dl)

Keywords: acei arb hypotension general anesthesia methohexital propofol
safety evaluation study for patients with polycythemia vera

Conditions: Polycythemia Vera

Summary: this is phasei dose-escalation study to evaluate the safety and pharmacokinetics of ppmx-t003 in polycythemia vera


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of pv according to either the 2008 or 2016 who classification criteria * pv patients being only treated with phlebotomy and the interval is 4-9 weeks exclusion criteria: * patients administrated drugs for pv treatment such as hydroxyurea or ruxolitinib (aspirin is excluded)

Keywords: myeloproliferative neoplasms
dynamic and static autoregulation after brain injury

Conditions: Acute Brain Injuries; TBI (Traumatic Brain Injury); Intracranial Hemorrhages

Summary: the aim of the study assesses static and dynamic cerebrovascular autoregulation daily over one week in patients with traumatic brain injury or intracranial hemorrhage to quantify the temporal profile of the autoregulatory status.


Eligibility criteria:
inclusion criteria: * traumatic brain injury * intracranial hemorrhage exclusion criteria: * measurement of tcd were impossible * injury of the legs (if the both tigh cuffs for dynamic autoregulation could not be fixed)

Keywords: dynamic cerebrovascular autoregulation static cerebrovascular autoregulation acute brain injury transcranial doppler ultrasound critical care
fuchs' endothelial dystrophy: clinical characteristics, treatment outcome, and pathology

Conditions: Fuchs' Endothelial Corneal Dystrophy

Summary: background fuchs' endothelial dystrophy fuchs' endothelial dystrophy (fuchs' ed) is characterized by changes on the inside of the cornea, which leads to a substantial decline in visual acuity. the only effective treatment option for fuchs' ed is corneal transplantation. corneal transplantation corneal transplantation surgery has seen major advances in the last decade, and the descemet's stripping automated endothelial keratoplasty (dsaek) procedure has now become the preferred method. outcome there have been a substantial number of publications on outcome after dsaek surgery, and the procedure has several advantages over the former preferred method of transplantation, penetrating keratoplasty (pk). despite the apparent success of the dsaek procedure, visual acuity is seldom fully restored even in otherwise healthy eyes. several studies have tried to clarify this matter but so far results have been conflicting. hypotheses 1. the reduction in visual acuity and contrast sensitivity in patients with fuchs' endothelial dystrophy is correlated with corneal thickness, corneal light scatter, and the type and magnitude of optical disrupting guttae in descemet's membrane. 2. the subjective visual function after corneal transplantation with a posterior lamellar graft is correlated with the optical properties of the grafted cornea (thickness, light scatter, irregularities on the anterior, and posterior corneal surfaces) materials and methods in a controlled prospective trial of dsaek patients, we aim to register different morphological patterns, monitor visual performance and optical parameters. three sex and age-matched groups will be compared: group 1: 40 patients that undergo dsaek surgery group 2: 40 patients that undergo combined cataract and dsaek surgery. group 3: control group of 40 patients with normal corneas that undergo cataract surgery.

investigation outline: * presence of the following patterns will be registered for each patient: scattered guttae, confluent guttae, diffuse corneal oedema or confined corneal oedema * refractive properties: objective and subjective refraction * visual performance: visual acuity (etdrs), contrast sensitivity (fract method) * corneal characterization: corneal sensibility (cochet-bonnet), in vivo confocal microscopy, specular microscopy, anterior segment oct, olcr, pentacam with densitometry, and slit-lamp investigation will be performed. * catquest 9sf questionnaire

Eligibility criteria:
inclusion criteria: * fuchs' endothelial dystrophy * candidate for dsaek surgery exclusion criteria: * other ocular comorbidities that potentially limit vision or contrast vision

Keywords: endothelial keratoplasty descemet's stripping automated endothelial keratoplasty lamellar keratoplasty
effect of real-time continuous glucose monitoring system in overweight or obese adults with prediabetes

Conditions: Continuous Glucose Monitoring; Prediabetic State; Obesity

Summary: in korea, 5 million adults aged 30 years or older have diabetes. the development and expansion of korea's economy and society, has led to dramatic chances in people's lifestyle and diet habits, and an increase in life expectancy. however, changes in lifestyle and diet habits related to the improvements of socioeconomic status may contribute to an increased diabetes burden in korea. therefore, it is important to prevent diabetes. the purpose of this study was to evaluate the effects of real time-continuous glucose measurement (rt-cgm) system compared to only lifestyle modification group on blood glucose, lipid profile and diabetes prevention in prediabetic adults with overweight or obesity.

optimising patient adherence to prescribed lifestyle interventions to achieve improved blood glucose control remains a challenge. combined use of real-time continuous glucose monitoring (rt-cgm) systems may promote improved glycaemic control. thirty adult with overweight or obesity and pre-diabetes are randomised to using either rt-cgm or self monitoring of blood glucose (smbg) for 1 week with lifestyle intervention. after 3 month, outcomes were glycemic control (hba1c, fasting glucose), weight, and lipid profile assessed pre- and post-intervention.

Eligibility criteria:
inclusion criteria: * ≥ bmi 23 kg/m2 * impaired fasting glucose (fasting glucose 100 to 125 mg/dl) or impaired glucose tolerance (2-h plasma glucose during oral glucose tolerance test (ogtt) 140 - 199 mg/dl) or hba1c 5.7% to 6.4% exclusion criteria: * type 1 diabetes or type 2 diabetes or undergoing treatment for diabetes * clinical history including malignancy * fast history of cardiovascular disease (e.g. myocardial infarction, stroke), surgery, and trauma which may affect blood glucose within last 6 months * taking medication (e.g. glucocorticoid, antipsychotics, anticholinergic drug etc.) which affect blood glucose * acute infection within last 1 month * pregnancy
evaluation of the new variant 501y.v2 of covid-19

Conditions: Covid19

Summary: in january 2021, the incidence of covid-19-and its mortality started rising for the third time in france. this rise may associate with three emerging variants, namely, v1, v2, and v3, which are the 20i/501y.v1 ("english"), 20h/501y.v2 ("south african"), and 20j/501y.v3 ("brazilian") variants, respectively. v1 was recently suggested to increase mortality in people in the united kingdom who tested positive for covid-19 on community screening. very little is known about v2 infection, including its outcomes relative to other strains. in early 2021, v2 spread to the grand-est region (northeastern france). here, the investigators aimed to report mortality data of patients admitted in icu between february and april 2021 in 3 hospitals in grand-est: metz, thionville and nancy.


Eligibility criteria:
inclusion criteria: * admission in icu in february, march or april 2021 * patient with a sars-cov-2 positive polymerase-chain reaction test * patient with 20i/501y.v1 ("english") or 20h/501y.v2 ("south african") sars-cov-2 variants exclusion criteria: * opposed to use data

Keywords: mortality sars-cov-2 variants intensive care unit 20i/501y.v1 20h/501y.v2
lu ag06466 in participants with post traumatic stress disorder (ptsd)

Conditions: PTSD

Summary: the purpose of this study is to investigate the effect of lu ag06466 after multiple doses of 30 milligrams (mg) in participants with ptsd.

the crossover study consists of two treatment periods of 15 days duration. on day -1 or day 1 of treatment period 1, eligible participants will be randomized (1:1) to a sequence of treatments (either lu ag06466-placebo or placebo-lu ag06466) with 15 participants are planned per sequence. each treatment period will be separated by a washout period of ≥7 and ≤14 days.

Eligibility criteria:
inclusion criteria: * the participant has ptsd, diagnosed according to diagnostic and statistical manual diploma in social medicine-5 (dsm-5), and confirmed by the mini international neuropsychiatric interview (mini). * the participant has a clinician-administered ptsd scale for dsm-5 (caps-5) total score ≥28 at screening and baseline. * the participant has alterations in arousal and reactivity, confirmed on caps-5. * the participant has ongoing sleep disturbances, confirmed on caps-5. * the participant is willing to discontinue all prohibited medications during the study and to complete a washout of psychotropic medication during the washout period. * the participant does not have any magnetic resonance imaging (mri) contraindications. exclusion criteria: * the index traumatic event that led to development of ptsd took place \>15 years or \<6 months before screening. other inclusion and exclusion criteria may apply.
continuous glucose monitoring for outpatient diabetes management after hospital discharge

Conditions: Type 2 Diabetes Mellitus (T2DM); Type 1 Diabetes Mellitus (T1DM); Hyperglycemia

Summary: this study aims to improve patient awareness of the utility of continuous glucose monitoring systems in blood glucose monitoring and to improve patient satisfaction regarding diabetes care, particularly in the matter of blood glucose monitoring, at the transitions of care from the inpatient setting to the ambulatory setting.


Eligibility criteria:
inclusion criteria: * non-pregnant adults, ages greater than or equal to 18 years, admitted to vumc * able to give informed consent * hyperglycemia requiring insulin therapy including subcutaneous insulin injection or continuous subcutaneous insulin infusion (patient's own insulin pump) during hospitalization and at the time of discharge * poc glucose or venous glucose levels in the 24 hours prior to participation need to be 70-350 mg/dl * need glucose readings greater than or equal to one time per day * mental status and dexterity adequate to use libre 3 plus or dexcom g7 sensors with libre 3 or dexcom g7 application on patient's smartphone exclusion criteria: * currently using libre 3 plus or dexcom g7 cgms during hospitalization or have used libre 3 plus or dexcom g7 cgms in the past 3 months * does not have smartphone compatible with libre 3 app or dexcom g7 app * received chemotherapy during current hospitalization * planning on major surgery within 10-15 days * hemodialysis or peritoneal dialysis * requiring vasopressors, intubation, sedation, or admission to an intensive care unit * vitamin c use of more than 500 milligrams per day * hydroxyurea use * acetaminophen use of more than 4 grams per day or 1 gram every 6 hours * significant pitting edema (3+ or greater) i.e. cirrhosis with ascites, congestive heart failure with edema, nephrotic syndrome, or signs of poor perfusion * presentation in diabetic ketoacidosis or hyperosmotic nonketotic state * skin allergy to adhesives
effectiveness of audiovisual versus written postoperative instructions for patients undergoing minor hand procedures

Conditions: Carpal Tunnel Syndrome; Hand Cyst Ganglion; Trigger Finger

Summary: the utility and effectiveness of video-based instructions (vbi) versus standard written instructions was not previously investigated in hand surgery; thus, the objective of this study is to evaluate the effectiveness of audiovisual instruction as compared to regular verbal instructions given to patients undergoing common hand procedures, including instruction recall and compliance, patient education, patient satisfaction with the information given, patient satisfaction with operative experience.

outcomes of hand surgery are greatly dependent on factors outside the operating theater as well. these include patient compliance to preoperative instructions that consist of proper surgical site care, proper positioning, and following occupational therapy protocols. previous studies have shown that video-based information provide greater patient satisfaction than verbal instructions. visual information was also reported to decrease patient anxiety regarding the procedure and increases patient education in terms of procedure risks and benefits(1-5). the utility and effectiveness of video-based instructions (vbi) versus standard written instructions was not previously investigated in hand surgery; thus, the objective of this study is to evaluate the effectiveness of audiovisual instruction as compared to regular verbal instructions given to patients undergoing common hand procedures, including instruction recall and compliance, patient education, patient satisfaction with the information given, patient satisfaction with operative experience. the secondary objective is to evaluate if vbi result in better outcomes than standard written instructions.

Eligibility criteria:
inclusion criteria: please ensure that all items below are satisfied to be included in the study. * patient undergoing hand and/or upper extremity surgery with dr. thibaudeau * patient ≥ 18 years old * patient who comprehends instructions provided in english and/or french * patient who can navigate the internet to complete an online post-operative questionnaire exclusion criteria: please ensure that none of the following items are selected to be included in the study. * patient presenting with intra-articular, open, or pathological fractures * patient presenting with associated tendon or nerve injuries * patient receiving definitive surgery ≥21 days after injury * patient with previous surgeries/deformity in the hand * patient with pre-existing severe joint disease (rheumatoid arthritis, finger joint stiffness, or non-union) * patient with medical contraindications to surgery * patient who is unable to comply with rehabilitation * patient who is unwilling to be followed up * patient with dementia * patient with significant mental illness * patient who is unable to provide informed consent
respiratory resistance training on sleep quality in persons with spinal cord injury

Conditions: Spinal Cord Injury

Summary: the purpose of this study is to determine if the use of a respiratory resistance trainer will increase respiratory muscle strength, improve sleep quality and improve quality of life in individuals with spinal cord injury. hypothesis: use of the respiratory resistance trainer will improve respiratory muscle strength, improve sleep quality, and improve quality of life among individuals with spinal cord injury.

individuals with spinal cord injury experience varying degrees of reduced muscle function. those individuals with high level spinal cord injury, cervical region, may experience reduced diaphragm function. this reduction in function may affect daytime activities as well as sleep quality. sleep quality in people with spinal cord injury is considered to be worse than sleep quality in the general population. the use of respiratory resistance training devices has been shown to increase muscle strength in people with spinal cord injury. there have been not studies to document potential improvements in sleep quality among individuals with spinal cord injury following respiratory resistance training.

Eligibility criteria:
inclusion criteria: * tetraplegia * quadriplegia exclusion criteria: * na

Keywords: spinal cord injury respiratory muscle training sleep quality
ctdna-based mrd assessment in local advanced esophageal carcinoma

Conditions: Esophageal Squamous Cell Carcinoma

Summary: to analyze the relationship between the dynamic changes of circulating tumor dna (ctdna) and tumor relapse of esophageal squamous cell carcinoma treated by concurrent chemoradiotherapy.


Eligibility criteria:
inclusion criteria: 1. 18-75 years old. 2. ecog 0-1. 3. esophageal squamous cell carcinoma confirmed by pathology. 4. no radiotherapy, chemotherapy, or other treatments prior to enrollment. 5. locally advanced esophageal squamous cell carcinoma (ii-iva, ivb with supraclavicular lymph node metastasis). 6. no severe abnormal hematopoietic, cardiac, pulmonary, renal, hepatic function, or immunodeficiency. 7. informed consent signed. exclusion criteria: 1. less than 50.4gy/28fx of radiotherapy dose. 2. without concurrent chemotherapy. 3. pregnant or breastfeeding women or fertile patients who refused to use contraceptives.
a study investigating the safety, recovery, and pharmacodynamics of multiple oral administrations of snipr001 in healthy subjects

Conditions: E.Coli Infections; Bloodstream Infection

Summary: this is a phase 1, randomized, double-blind, placebo-controlled, multiple dose, dose escalation study in healthy participants, investigating the safety, tolerability, recovery, and pd of multiple oral administrations of snipr001.

approximately 36 healthy male and female participants will be randomized to one of 3 active oral doses of snipr001 or matching placebo, administered twice a day (bid) for 7 days. subjects will be followed up until 6 months after receiving the last dose of snipr001.

Eligibility criteria:
inclusion criteria: * signed informed consent * male or female healthy subject defined as no known clinically relevant organ abnormality, or disease diagnosis, as per investigator discretion * no clinically significant abnormalities indicated by safety laboratory test results * age between 18 years and 65 years * e. coli present in feces sample * normal defecation pattern (at least once daily) * willing to participate in the study and provide fecal samples exclusion criteria: * treatment with antibiotics or any other prescription medication within the last 30 days prior to or during screening * use of probiotics (not including dairy products) within the last 30 days prior to or during screening * smoking (cigarettes, pipes, vaping products, etc.) within the last 3 months prior to or during screening * 6 months prior to or during screening, recent history of alcohol or drug abuse, or current regular alcohol consumption of more than 14 units per week (one unit of alcohol equals one beer (285 ml), one glass of wine (125 ml), or one glass of spirits (25 ml)) * positive alcohol or drugs of abuse test * pregnancy or lactating or intention of becoming pregnant (all females to agree to use highly effective contraception (defined as those, alone or in combination, that result in a low failure rate i.e., less than 1% per year) for the entire study duration * obesity as defined by who i.e., bmi\>32 kg/m2 * known to be hiv-positive * known active hepatitis b and/or hepatitis c infection * known congenital or acquired immunodeficiency * allergy to any component of the trial drug and ant-acid treatment * regular use of medications that affect gastrointestinal motility e.g., antidiarrheals, stool softeners and laxatives, glp-1 analogues