Kornimate/medical-research-clean huggingface dataset:
surgical approach for primary hyperparathyroidism in the elderly

Conditions: Multigland Disease in Primary Hyperparathyroidism

Summary: following a personal observation and a retrospective analysis of the data, the investigators hypothesise that there is increased frequency of multiple gland disease in primary hyperparathyroidism in the elderly. this study will include patients over the age of 65, diagnosed with primary hyperaprathyroidism, referred for surgery and suspected to have a single adenoma according to preoperative imaging. surgery will begin with a focal parathyroid exploration as suspected followed by an exploration of the other gland at the same time. data will be analysed to determine the frequency of multigland disease in this population.


Eligibility criteria:
inclusion criteria: * patient with primary hyperparathyroidism. * patients with an indication for surgery. * suspected adenoma on preop images. * minimum age of 65. exclusion criteria: * patients younger than 65. * cases where imaging didn't locate any adenoma. * patients who did not consent to participate in the study.

Keywords: primary hyperparathyroidism multigland disease neck exploration elderly
clinical feasibility study of the bariton™ system in obese or overweight patients.

Conditions: Obesity

Summary: safety and efficacy evaluation of the bariton™, bariatek medical gastric restriction and biliodigestive diversion device.


Eligibility criteria:
inclusion criteria: 1. male and female subjects aged between 25 and 60 years inclusive 2. a bmi between 30.0 and 40.0 kg/m2 inclusive with a history of obesity for at least 2 years and a history of failure of supervised weight loss program 3. stable weight, i.e. \< 5% change in body weight for minimum of 3 months prior to enrolment 4. willing and able to provide written informed consent 5. willing and able to comply with the study procedures and follow-up schedule
ketamine pilot study

Conditions: Rattlesnake Envenomation

Summary: this is a pilot study to evaluate pain responses from two different approved medications (ketamine and fentanyl) in the treatment of pain after rattlesnake envenomation (rse). both medications are currently used in standard practice to treat both acute and chronic pain and are options for pain management after rse. multiple studies exist showing ketamine to be both safe and effective for the treatment of acute pain, and to be as good as or better than opioids for this indication. the specific comparison of ketamine to fentanyl, however, has never been studied for the treatment of acute pain after rattlesnake envenomation in the united states. the investigators plan to measure pain scores after a single dose of ketamine or fentanyl in patients shortly after being envenomated, followed by continued treatment of pain guided by the treating doctor. there will be no restrictions on additional pain medications given and no other changes to the treatment of these patients during their hospitalization. this research is important because pain after rse can be difficult to control and may require frequent, high doses of opioids for several days. an effective non-opioid medication would be helpful both to better-control pain and to reduce exposure to opioids in this patient population. this study will compare patient-reported pain scores after receiving a single dose of ketamine or fentanyl in patients with rattlesnake bites who have been admitted to the toxicology service at banner - university medical center phoenix (bumcp).

multiple studies have shown ketamine to be safe and effective agent for acute pain syndromes. rses classically result in severe pain that can be difficult to control, despite use of opioids, non-opioid analgesics, and positioning techniques, including splinting and elevation. furthermore, the ongoing opioid epidemic pushes clinicians to explore non-opioid agents to avoid unnecessary exposure of patients to these high-risk medications. at least one small study has shown ketamine to be safe in rattlesnake envenomated patients.

Eligibility criteria:
inclusion criteria: * ages ≥ 18 years. * able to speak and understand english. * rse requiring iv pain medication for nrs pain score \> 5. * no allergy to ketamine or fentanyl. * ability to provide informed consent. * ≤ 24 hours from envenomation. exclusion criteria: * pregnant or lactating. * prisoners. * refugees. * history of schizophrenia. * clinically intoxicated. * on buprenorphine therapy. * history of uncontrolled hypertension * increased intracranial pressure * systemic envenomation

Keywords: acute pain after rattlesnake bite rattlesnake envenomation low dose ketamine pain dose ketamine
virtual world health behavior counseling for patients with diabetes

Conditions: Type 2 Diabetes

Summary: comparison of 2 methods of delivery health education for african-american women with type 2 diabetes. the two methods are: face to face education in small groups, as compared to delivering the same curriculum in the virtual world, second life.

this study will provide health education to african-american women with type 2 diabetes either face to face, or using the internet. the study seeks to determine how feasible the internet method is for this type of health education, and how it compares to the face to face method. patients will be recruited from boston medical center. they will do baseline surveys and have blood drawn. they will then be randomized into receiving their diabetes education in a face to face group at bmc, or receiving it online while at home. the online group will receive a computer to access the internet program and internet access. both groups will participate in 8 diabetes education groups, and 4 individual counseling sessions. subjects will complete surveys before and after the study to measure changes in physical activity, diet, and use of medications, and will have blood tests drawn at bmc before and after the study to measure changes in diabetes control, cholesterol. they will also have blood pressure measured before and after the study period.

Eligibility criteria:
inclusion criteria: 1. diagnosed with t2dm 2. hba1c level \>= 8.0 3. currently treated with diet, oral hypoglycemics or insulin. if currently on insulin, must have a history of prior therapy with diet alone or oral hypoglycemic agents 4. african-american origin 5. \>= 18 years old 6. telephone in home or easy access to one 7. able to understand and participate in the study protocol 8. functionally capable of meeting the activity goals 9. understands and can provide informed consent 10. physician approval to participate in the study. exclusion criteria: 1. history of diabetic ketoacidosis 2. gestational diabetes 3. unable or unwilling to provide informed consent 4. plans to move out of the area within the 12-month study period 5. required intermittent glucocorticoid therapy within the past 3 months 6. experienced an acute coronary event (myocardial infarction or unstable angina) within the previous 6 months 7. has a medical condition that precludes adherence to study dietary recommendations (e.g., crohn's disease, ulcerative colitis, end-stage renal disease) 8. has a medical or psychiatric illness (i.e., dementia, psychiatric hospitalization or suicidality within past 5 years or takes an neuroleptic medication). we will not exclude based on history of depression or anxiety or taking anti-depressants or anti-anxiety medications.

Keywords: diabetes mellitus, non-insulin dependent
immunopathologic profiles and blood biomarkers in patients with ipf

Conditions: Idiopathic Pulmonary Fibrosis

Summary: examination of expression of pd-l1, pd-l2, beta- catenin, b-cell follicles and tenascin- c in patients with ipf compared with other interstitial lung diseases. examination of anti hsp 70, p-anca, c-anca, cd4+/cd28- and cd8+/cd28- cells in patients with ipf compared with other interstitial lung diseases. compare the above mentioned findings with changes in pulmonary function tests, 6 minute walking test, exacerbation and mortality over a 2 year follow-up period.

examination of expression of pd-l1, pd-l2, beta- catenin, b-cell follicles and tenascin- c in cryobiopsies from the lungs inpatients with ipf compared with other interstitial lung diseases. examination of anti hsp 70, p-anca, c-anca, cd4+/cd28- and cd8+/cd28- cells in blood samples in patients with ipf compared with other interstitial lung diseases. compare the above mentioned findings with changes in pulmonary function tests, 6 minute walking test, exacerbation and mortality over a 2 year follow-up period.

Eligibility criteria:
inclusion criteria: * patients suspected of having an ild who are having cryobiopsies performed exclusion criteria: * bmi \> 35 * dlco \< 35% * fvc \< 45% * pulmonary hypertension * cardiac or other severe comorbidity that will increase the risk of complications
implementation of a new algorithm for hrr gene mutation testing in patients with mpc through liquid biopsy integration

Conditions: Metastatic Prostate Cancer (mPC)

Summary: implementation of a new algorithm for hrr gene mutation testing in patients with mpc through liquid biopsy integration

analysis of the current clinical landscape of mpc italy to identify gaps and opportunities for improvement. patient identification and enrollment blood sample collection and plasma purification ctdna extraction and ngs analysis of homologous recombination repair (hrr) genes. clinical real-world data (rwd) and molecular analysis data collection testing algorithm development based on collected data finalization and sharing of a best practice model for diagnostic procedures in mpc patients

Eligibility criteria:
inclusion criteria: * patients with metastatic prostate cancer whose tumor tissue is unavailable or inadequate for molecular testing. • written informed consent must be signed and dated by the patient and the investigator prior to inclusion. exclusion criteria: * unable to provide written informed consent

Keywords: hrr liquid biopsy
will lactobacillus increase cure rate after treatment of bacterial vaginosis and chronic vulvovaginal candida

Conditions: Bacterial Vaginosis

Summary: from the earlier studies the investigators have treated women with bacterial vaginosis and cronic vulvovaginal candida. the investigators have then treated them with laktobacilli 10 days for 2 month. the investigators will continue to follow them and investigate if treatment with lactobacilli every week for 6 month will increase cure rate.

clinical diagnosis of bacterial vaginosis using air dried smears combined with hay/ison classification. test of cure every month or every menstrual cycle using self taken smears. the cure will be if the woman are in group 1 according to hay/ison classification. this will also allow us to use molecular diagnosis of bv to test cure and compare this with hay/ison. test of cure for candida patiens are no visibel candida on wet smear and free of symtoms of candida.

Eligibility criteria:
inclusion criteria: * diagnosis of bacterial vaginosis according to hay/ison or with candida diagnosed with wet smear. exclusion criteria: * women with chlamydia infection, pregnancy, herpes
inspiratory muscle training in pulmonary hypertension

Conditions: Pulmonary Hypertension

Summary: the purpose of this study is evaluate the effect the inspiratory muscle training on the functional capacity of patients with pulmonary hypertension.

pulmonary hypertension (ph) is a syndrome, in the case of hemodynamic alteration of a number of diseases and processes, such as the progressive increase in pulmonary vascular resistance, right heart failure and early death. frequently patients with ph have reduced functional capacity, quality of life and survival. it was demonstrated recently that patients with hp also have inspiratory muscle weakness, possibly further increase the fatigue and dyspnea during exercise. to meet this need, inspiratory muscle training can lead to significant improvement in respiratory muscle strength, exercise tolerance and dyspnea, thus resulting in reduction of discomfort during activities of daily living, increase in exercise capacity and improved quality of life in different situations.

Eligibility criteria:
inclusion criteria: * clinical diagnosis pulmonary hypertension * world health organization (who) functional class ii to iv * inspiratory muscle weakness exclusion criteria: * obesity * chronic obstructive pulmonary disease * orthopedic and neurological disease

Keywords: pulmonary hypertension inspiratory muscle training inspiratory muscle weakness pulmonary functional functional capacity quality of life
post operative continuous active combination sex steroids for the prevention of recurrent endometrioma formation

Conditions: Endometrioma

Summary: the aim of this study is to determine whether or not continuous combined oral contraceptive pills (cocp's) decrease the risk of recurrent endometrioma formation. the investigators' hypothesis is that patients who have endometriomas surgically removed and then are started on cocp's will have a decreased incidence of recurrent endometrioma formation. the investigators' research protocol is designed to show a statistically significant decreased incidence of endometrioma formation in the hopes that physicians will use cocp's in patients they have removed an endometrioma in who do not desire immediate fertility. long term, the investigators hope to establish a standard of care that cocp's be used postoperatively in appropriate candidates to decrease the chance of recurrent endometrioma formation.

we plan to identify patients planning to undergo conservative surgery for endometrioma at the university of oklahoma private practice ob/gyn clinic and at the university of oklahoma resident women's clinic. after clear and appropriate consent and discussion regarding options, we plan to randomize patients to monophasic ocps vs. placebo following surgery. we plan to enroll 35 patients in each arm and follow them for 24 months following the surgery. surveillance with pelvic exam and transvaginal ultrasonography will occur at 2, 6 and 12 months. the patients surgery will be done prior to enrolling in our study. we will use information from their surgery only to confirm the diagnosis of endometrioma. the only procedure the subjects will undergo during the protocol are periodic transvaginal ultrasonography.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of ovarian endometriotic cyst that has been surgically excited. exclusion criteria: * current desire to achieve pregnancy or other contraindication to combined oral contraceptive pills.
oxygenated gel therapy in the management of oral aphthous ulcers

Conditions: Aphthus Ulcer

Summary: interventions of both groups: oxygenated gel group: 15 patients who used oxygenated gel (blue®m, wijhe, netherlands) were trained by the co-investigator (a.h) through real demonstration for topical application of the gel on aphthous ulcers, which entails the application of 1-2 ml of oxygenated gel directly to the ulcer two times per day and this was repeated for 7 days. triamcinolone acetonide group: 15 patients were treated with kenalog in orabase (triamcinolone acetonide 0.1% oral paste 5g), four times (i.e., at 8 am, 12 noon, 4 pm, and 8 pm) a day for 7 days at intervention group. patients in both groups were reexamined after treatment at different intervals (day 3, day 5, day 7, and day 10).


Eligibility criteria:
inclusion criteria: * clinically diagnosed patients with chronic aphthous stomatitis measuring ≤6 mm in size in the oral cavity and who gave written consent for participation. * only single ulcers were considered for the study. * systemically healthy patients. exclusion criteria: * the study excluded patients with a history of associated systemic disease. * cases of chronic aphthous stomatitis (major), lesions of herpetic form, numerous aphthae, and smoking. * patients with a history of hypersensitivity to the used agents. * pregnancy and lactation
familial and environmental factors behind migraine

Conditions: Migraine

Summary: migraine is a chronic neurological disease characterized by recurrent moderate to severe headaches often in association with a number of autonomic nervous system symptoms. migraines are believed to be due to a mixture of environmental and genetic factors. about two-thirds of cases run in families. changing hormone levels may also play a role, as migraines affect slightly more boys than girls before puberty, but about two to three times more women than men after puberty. the risk of migraines usually decreases during pregnancy. the exact mechanisms of migraine are not known. it is, however, believed to be a neurovascular disorder. the primary theory is related to increased excitability of the cerebral cortex and abnormal control of pain neurons in the trigeminal nucleus of the brainstem.

environmental influences play a role, but family studies suggest that defective genes may be primarily involved in disease causation. the mode of transmission of typical migraine in families is still unclear, but it is widely believed to be multifactorial although a role for a major susceptibility gene cannot be excluded. aim of study: we aim to study the familial risk for developed migraine and its relation to eeg changes.

Eligibility criteria:
inclusion criteria: * fullfilled migraine chriteria exclusion criteria: * genereal neurologic disease
characterization of cardiovascular diseases and risk factors in patients with suspected sars-cov2/covid-19 infection

Conditions: Cardiovascular Diseases; Cardiovascular Risk Factor; SARS

Summary: the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infects host-cells via ace2-receptors, which leads to pneumonia (covid-19) but also can lead to myocarditis (acute myocardial injury) and chronic damage to the cardiovascular system. therefore, cardiovascular protection may be necessary when treating patients with covid-19 infection. this may especially be necessary in patients with cardiovascular diseases, risk factors, and co-medication.


Eligibility criteria:
inclusion criteria: * patients with suspected sars-cov2/covid-19 infection exclusion criteria: * unwillingness to participate
cab-axl-adc safety and efficacy study in adult and adolescent patients with sarcoma

Conditions: Undifferentiated Pleomorphic Sarcoma; Myxofibrosarcoma

Summary: the objective of this study is to assess the safety and efficacy of mecbotamab vedotin (ba3011) in solid tumors.

this is a multi-center, open-label, phase 1/2 study designed to evaluate the safety, tolerability, pk, immunogenicity, and antitumor activity of mecbotamab vedotin (ba3011), a conditionally active biologic (cab) axl-targeted antibody drug conjugate (cab-axl-adc) in patients with advanced solid tumors. phase 1 of this study will consist of a dose escalation phase (enrollment complete as of oct 2019) and a dose expansion phase (enrollment complete as of jan 2024). phase 2 will consist of two parts. part 1 is designed to evaluate mecbotamab vedotin alone and with nivolumab in patients with various types of advanced sarcomas (enrollment complete as of jan 2024). part 2 will evaluate the safety and efficacy of mecbotamab vedotin in patients with undifferentiated pleomorphic sarcoma (ups) and myxofibrosarcoma (mfs).

Eligibility criteria:
inclusion criteria: * patients must have measurable disease. * age ≥ 12 years (phase 2) * adequate renal function * adequate liver function * adequate hematological function * have an eastern cooperative oncology group (ecog) performance status of 0 or 1. * life expectancy of at least three months. exclusion criteria: * patients must not have clinically significant cardiac disease. * patients must not have known non-controlled cns metastasis. * patients must not have a history of ≥ grade 3 allergic reactions to mab therapy as well as known or suspected allergy or intolerance to any agent given during this study. * patients must not have had major surgery within 4 weeks before first ba3011 administration. * patients must not have had prior therapy with a conjugated or unconjugated auristatin derivative/vinca-binding site targeting payload. * patients must not have known human immunodeficiency virus (hiv) infection, active hepatitis b and/or hepatitis c. * patients must not be women who are pregnant or breast feeding.

Keywords: late stage stage 3 stage 4 cancer undifferentiated pleomorphic sarcoma myxofibrosarcoma
bed-side ultrasound in neutropenic enterocolitis

Conditions: Neutropenic Enterocolitis

Summary: neutropenic enterocolitis (nec) is a life-threatening complication of leukemic and solid tumors patients (pts) treated with chemotherapy (cht) with high mortality rate up to 50-100%. perforation occurs in 5%-10% of cases. early diagnosis is crucial to start conservative medical management (cmm), which appears the optimal strategy for most cases. nec should be always suspected in neutropenic pts with abdominal pain, fever and diarrhea. ultrasound (us) can be used to evaluate bowel-wall thickening (bwt). the objective of this study is to evaluate prospectively if us can detect early signs of nec and guide a prompt treatment (cmm or surgical) and thus reduce mortality.


Eligibility criteria:
inclusion criteria: all patients admitted in hematology ward university of pisa (italy) to receive chemotherapy who experienced neutropenia related to chemotherapy exclusion criteria: patients admitted in hematology ward university of pisa (italy) who did not receive chemotherapy

Keywords: nec, bed side ultrasound, diagnosis, treatment