Kornimate/medical-research-clean huggingface dataset:
boston arch 4f intervention to reduce fall risk in people with hiv and alcohol use

Conditions: HIV Infection; Alcohol Consumption; Falls, Accidental; Falls

Summary: this study is being conducted to assess the acceptability and feasibility of a randomized trial of a 10 week virtual intervention to reduce fall risk in people with hiv who consume alcohol. the hypothesis is that this randomized trial of the fall prevention intervention will be found to be feasible and acceptable in this pilot stage. standardized assessments will be administered in-person at boston university medical campus to assess various domains including fall risk, fear of falling, physical performance measures (such as grip strength, balance, and gait speed), substance use, and other related measures. the intervention has 3 main components: home exercises, virtual group sessions and weekly phone check-ins. home exercise will be customized to match the current fitness level of participants. participants will be asked to complete assigned exercises 3 times per week. additionally, there will be a weekly virtual group session led by an occupational therapist trained in group facilitation via zoom. the virtual group sessions will be used to help answer any questions and lead a discussion around challenges related to falls. finally, a member of the research team will check-in with participants once per week to answer any remaining questions that participants have, provide individual feedback on exercises, and set up reminders for the upcoming week. reminders will be tailored to the individual participant's needs to remind the participant to complete the intervention's components.


Eligibility criteria:
inclusion criteria: * prior or current participant in the boston arch 4f cohort * any alcohol consumption in the last 30 days using addiction severity index * deemed a fall risk using the cdc steadi fall risk assessment form * has reliable access to a phone or computer with internet connection exclusion criteria: * requires wheelchair for mobility

Keywords: hiv infection alcohol consumption falls, accidental falls substance use intervention study
strongest families (formerly family help program): pediatric disruptive behaviour disorder

Conditions: Pediatric Disruptive Behaviour Disorder

Summary: the purpose of the strongest families (formerly family help program)is to evaluate the effectiveness of the strongest families distance intervention compared to usual or standard care that is typically provided to children with mild to moderate disruptive behaviour symptomology. this is a single-centre trial based at the iwk health centre. the primary outcome is change in diagnosis.

the purpose of the strongest families (formerly family help program): is to deliver, primary care mental health services to children and their families in the comfort and privacy of their own home. approximately 60 children (3-7 years of age)suffering from mild to moderate (but clinically significant) symptoms of pediatric behavior disorder will be randomized. the intervention is delivered from a distance, using educational materials (manuals, video-tapes, audio-tapes) and telephone consultation with a trained paraprofessional "coach" who is supervised by a licensed health care professional. the telephone coach delivers consistent care based on written protocols, with on-going evaluation by a professional team. fifty percent of the eligible participants will receive family help program telephone-based treatment and 50% will be referred back to their family physician to receive standard care as determined by that physician. those receiving standard care will be evaluated for outcome results and then compared to the strongest families treated participants. it is anticipated that strongest families treatment will be proven to be as or more effective than standard care.

Eligibility criteria:
inclusion criteria: * child 3 to 7 years of age * child had behavioural problems for 6 months or longer * access to a telephone in the home * speak and write english * mild to moderate disruptive behaviour symptomology exclusion criteria: * severe disruptive behaviour symptomology * received similar intervention within past 6 months * autism or schizophrenia * child has intellectual impairment
pulsed radiofrequency therapy for hand osteoarthritis pain

Conditions: Hand Osteoarthritis

Summary: different types of pain may be present in patients with hand osteoarthritis, including nociceptive pain and non-nociceptive pain. this makes adequate pain treatment difficult, and thus new treatment options are needed. to this end, this trial will evaluate the effect of transcutaneous pulsed radiofrequency for the treatment of hand osteoarthritis pain.

in this randomized clinical trial, patients with hand osteoarthritis, recruited from the leiden university medical center rheumatology outpatient clinic, aged 18-80 and fulfilling hand pain criteria will be randomized to undergo trancutaneous pulsed radiofrequency therapy of the hand or a sham. the effect will be measured in change in 10 point numeric rating scale for pain in the hand over 6 weeks. this rct will have little burdens and risk for the subjects. the proposed intervention, tprf, is well tolerated, with no known serious side effects.

Eligibility criteria:
inclusion criteria: * age 18-80 * hand osteoarthritis according to the acr criteria * hand pain of at least 30mm on a 100mm vas * chronic hand pain exclusion criteria: * known inflammatory rheumatic diseases * psoriasis * seropositivity for rheumatoid factor of anti-ccp antibodies * no understanding of the dutch language * fibromyalgia (following the acr 2011 classification criteria) * neurological disorders interfering with pain perception and measurements * carpal tunnel syndrome interfering with pain perception and measurements * history of chemo- and/or radiotherapy * spinal surgery or spinal trauma with lasting complaints interfering with pain perception and measurements * cognitive impairment or psychiatric conditions interfering with pain perception and measurements * pregnancy or breast-feeding * eye surgery for glaucoma or keratoconus or other surgery of the cornea in the three preceding months * presence of an implantable cardioverter-defibrillator (icd), neurostimulator or pacemaker * metal implants in the hand, arm, shoulder or neck of the side that is to be treated
evaluation of clinical decision support in opioid tapering

Conditions: Medication Abuse; Harm Reduction; Opioid Use Disorder; Opioid Prescribing; Opioid Overdose; Prevention

Summary: the 2022 center for disease control and prevention (cdc) clinical practice guideline for prescribing opioids for pain recommends that when tapering a patient's opioid dose, doses should be decreased at a slow rate to reduce the risk of withdrawal symptoms, overdose, and to promote tolerance of the tapering. this project will evaluate a clinical decision support (cds) tool in the form of a clinical care pathway that gives providers information, recommendations, and educational material on strategies for opioid tapering. primary care providers will be randomized at the clinic location to a control arm or intervention arm. the control arm will have the clinical care pathway available, but will not be reminded of the pathway when tapering a patient. the intervention arm will receive a nudge when prescribing a tapering opioid strategy to a patient to use the clinical care pathway. the rate of opioid tapering in line with cdc guidelines will be examined as well as long-term patient outcomes of opioid overdose or poisoning using existing patient health records. the study period will be approximately 18 months.


Eligibility criteria:
inclusion criteria: primary care patients being tapered from an opioid. tapering patients: * have an active opioid prescription for more than 3 months and * prescribed more than 90 morphine milligram equivalents (mme) per day or * co-prescribed an opioid and benzodiazepine or * received a reduction in opioid dosage by more than 5% mme per day exclusion criteria: * patients \ 89 * patients with active cancer diagnosis in last 1 year * patients with hospice care/palliative care order * patients with sickle cell disease diagnosis
national survey of essential tremor plus in china

Conditions: Essential Tremor-plus

Summary: national survey of essential tremor plus in china（nsetp-china）is a multicenter cross-sectional study designed to investigate the clinical features of et-plus in mainland china.

essential tremor (et) is one of the most common adult-onset movement disorders, affecting 0.9% of the population across all ages worldwide. et is a chronic, progressive neurologic disease whose the most recognizable clinical feature is a 4\~12 hz kinetic tremor of the upper limbs, usually occurring during a variety of voluntary movements. the etiology and pathogenesis of et remain elusive. essential tremor-plus (et-plus) is a new term coined in 2018 mds consensus statement on tremor. et-plus is defined as tremor with the characteristics of essential tremor, with additional neurological signs of uncertain clinical significance, such as impaired tandem gait, questionable dystonic posturing, memory impairment, or other mild neurological signs of unknown clinical significance that do not suffice to make an additional syndrome classification or diagnosis. et-plus is a controversial new concept. we will use scales or questionnaires to investigate the common soft neurological signs of et-plus in mainland china. the details are as follows: (1) the tremor's impact on activities of daily living and clinical measurement of et severity are evaluated by the essential tremor rating assessment scale (tetras). (2) cognitive condition is assessed by mini mental state examination (mmse) and montreal cognitive assessment (moca). (3) the non-motor symptoms are evaluated by non-motor symptom scale (nmss). (4) clinical assessment of balance and gait in et-plus: we will use tandem walk, berg balance scale (bbs) and 10 meter walk timing test. (5) the unified dystonia rating scale (udrs) for evaluation of dystonia in et-plus. (6) the scale for the assessment and rating of ataxia (sara) is used to evaluate ataxia in et-plus.

Eligibility criteria:
inclusion criteria: patients diagnosed with et and/or et-plus by the consensus statement on the classification of tremors, from the task force on tremor of the international parkinson and movement disorder society. exclusion criteria: lack of capacity to consent to participate in the project
safety of combining modafinil and nicotine replacement therapy in treating nicotine dependent adolescents

Conditions: Tobacco Use Disorder

Summary: nicotine is one of the most widely abused substances in the united states. nicotine replacement therapy (nrt) is currently an effective treatment for nicotine dependence; however, even with nrt most people fail at quitting smoking after their first attempt. modafinil is a promising drug that may be useful in treating nicotine dependent individuals. the purpose of this study is to evaluate the safety of the combination of modafinil and nrt in treating nicotine dependent adolescent smokers.

nrt is a critical part of treating nicotine withdrawal symptoms, such as cravings, sleeplessness, poor concentration, and anxiety. the addition of modafinil, a promising pharmacologic agent, may enhance the effectiveness of nrt by further reducing inattention and depressed mood. the purpose of this study is to examine the safety of using both modafinil and nrt in treating nicotine dependent adolescents. in addition, this study will examine the effects of modafinil and nrt, alone and in combination, on alleviating symptoms of inattention and depressed mood. participants in this 12-day dose escalation study will be tested under eight different dose conditions. modafinil and nrt will first be tested alone; participants will be exposed to low doses prior to higher doses of medication. various modafinil-nrt dose combinations will then be tested. modafinil will be administered at 5 p.m. each day, and nrt will be self-administered at the start of each day in which a participant must complete lab tests. the following measures will be obtained at study visits occurring before and after the various modafinil-nrt dose combinations: nicotine withdrawal symptoms, medication side effects, activity level, cardiovascular response, and profile of mood states (poms).

Eligibility criteria:
inclusion criteria: * smokes 10 or more cigarettes per day exclusion criteria: * current use of any medication for a psychiatric disorder * positive drug screen test * uses smokeless tobacco

Keywords: nicotine dependence nicotine use disorder tobacco dependence
efficacy of multi-disciplinary integrated post-acute care in patients admission for heart failure

Conditions: Hospitalization Rate; Mortality Rate; Functional Recovery; Left Ventricle Ejection Fraction; NT-pro BNP

Summary: background: clinical heart failure patients always suffering from (1) worsen symptoms such as decreased activity tolerance, end-to-end breathing and excessive body fluid volume; (2) high medical expenses results from hospitalization; (3) reduced quality of life . in 2018, following instruction from national health insurance administration (nhia), the national taiwan university hospital (ntuh) undertook national health insurance post-acute care program, pac in charge of heart failure patients by multi-disciplinary integrated to reduce acute exacerbations(ae), control symptoms, improve quality of life and increase survival rate.

objective: to evaluate the outcome of patients with heart failure who been taken are of multi-disciplinary integrated instructed by national health insurance administration (nhia) methods: use retrospective case contrl study. adopted the hospitalized patients diagnosed with heart failure in the ntuh as the research sample, and collected the retrospective data for analysis in a two-group study design. (1) the experimental group is a patient who was managed by the nhia 's acute post-care plan. provide interdisciplinary comprehensive care in accordance with the norms and conduct health education during hospitalization. hospitalized chinese pharmacists, dietitians, physiotherapists and case managers participate in health education and will continue to be interviewed and have heart consultations within six months of discharge. (2)the control group received traditional health education in general care and routine health care. time of review: from february 2, 2018, the implementation of the national health insurance agency's acute post-care plan day to december 31, 2019, and continuous tracking of effectiveness for one year. exclusion conditions: (1) age over20 years, (2) long-term dialysis, (3) unconsciousness, (4) complete bed rest without self-care ability, (5) those with ventilator dependence, (6) ventricular assist device (vad) has been implanted, (7) heart transplants , (8) refused to join the research. the monitoring indicators: hospitalization rate within 180 days, mortality rate within one year , functional recovery, left ventricle ejection fraction (lvef), nt-pro bnp, etc.

Eligibility criteria:
inclusion criteria: clinical diagnosis of heart failure * the experimental group is a patient who was managed by the nhia 's acute post-care plan. provide interdisciplinary comprehensive care in accordance with the norms and conduct health education during hospitalization. hospitalized chinese pharmacists, dietitians, physiotherapists and case managers participate in health education and will continue to be interviewed and have heart consultations within six months of discharge.

Keywords: national health insurance administration post-acute care program heart failure multi-disciplinary integrated
efficacy of preventive ketamine on postoperative pain

Conditions: Postoperative Pain

Summary: * although bariatric surgery is mainly performed laparoscopically, analgesic optimization is still essential to reduce complications and to improve the patients' comfort. in laparoscopic sleeve gastrectomy, the intraoperative peritoneal instillation of bupivacaine hydrochloride (30 ml, 0.25%) was known to be safe and effective in reducing postoperative pain, nausea, and vomiting. * furthermore, usage of ketamine both as a pre and post-operative pain management is well established. ketamine can be used solely or in combination with other co-adjuvant drugs, increasing their efficacy. many therapeutic properties of ketamine have been attributed to its antagonism mechanism to n-methyl-d-aspartate receptors.


Eligibility criteria:
inclusion criteria: * - body mass index \> 35 and \< 60 kg/m2 * either medically free or with well controlled hypertension and/or diabetes. exclusion criteria: * - patient's refusal to participate in the study * bmi \> 60 kg/m2. * age less than 21 years. * patients with severe systemic disease which is not life-threatening. * patients on antipsychotics, antidepressants and/or corticosteroids. * patients with history of obstructive sleep apnea. * allergic reaction to any of the study medications.
the effect of hormonal contraceptives on androgens and glucose metabolism

Conditions: Contraception

Summary: the impact of different administration routes of hormonal contraceptives on androgen secretion, glucose metabolism and inflammation. a prospective randomized trial. the investigators assume, that transdermal or transvaginal hormonal contraception would have less effects on androgen levels, glucose metabolism and inflammatory markers than oral contraceptives.

45 patients are recruited in the study. each study group will consist of 15 women (aged 20-35 years) receiving oral, transdermal or transvaginal hormonal contraception continuously for 9 weeks. the subjects should have at least 2 months wash out period from all hormonal medication prior to the study. the measurements for serum sampling and ogtt will be performed before and after 9 weeks of medication.

Eligibility criteria:
inclusion criteria: * healthy women aged from 20 to 35 years * regular menstruation * no use of hormonal contraception or two months wash-out period * no contraindications for using hormonal contraception exclusion criteria: * irregular menstruation * smoking * alcohol addiction * pregnancy or nursing * hypersensitivity to any components of the products * headaches with focal neurological symptoms * serious or multiple risk factors for artery disease * undiagnosed abnormal genital bleeding * impaired glucose tolerance or dm-t2

Keywords: oral glucose tolerance test hormonal contraception androgens crp
wound healing abnormalities in major abdominal surgery

Conditions: Impaired Wound Healing; Factor XIII Deficiency

Summary: this clinical observational study investigates the incidence of wound healing abnormalities in patients undergoing major abdominal surgery. second aim of the study is, if wound healing deficits may be accompanied by abnormalities in blood coagulation parameters.


Eligibility criteria:
inclusion criteria: * age \>= 18 years * male or female * informed consent * major abdominal surgery exclusion criteria: * pre-existing coagulation abnormalities * pre-existing severe renal or liver failure * chemo- or radiochemotherapy

Keywords: major abdominal surgery coagulation extracellular matrix proteins wound healing after major abdominal surgery
pillow brace assessment on sleep quality of patients undergoing arthroscopic rotator cuff surgery

Conditions: Rotator Cuff Injury

Summary: rotator cuff surgery is an increasingly popular procedure in france. it is a common procedure for patients with shoulder tendon injuries, aimed at restoring mobility and reducing pain. although arthroscopic techniques have improved functional outcomes, managing postoperative pain, particularly at night, and its consequences remains a major challenge. studies highlight that postoperative nighttime pain can significantly affect sleep quality, delaying functional recovery and patient satisfaction. however, standard splints used for postoperative immobilization do not offer an optimal solution to this problem, leaving a significant gap in the care of these patients. given this observation, a splint incorporating a support cushion system could meet the specific needs expressed by patients who have undergone rotator cuff surgery, namely improving sleep quality by minimizing nighttime pain. this splint, called the "pillow brace," was developed internally at the jouvenet clinic. it therefore does not have ce marking. nevertheless, this study is based on the hypothesis that the use of a "pillow brace" could significantly improve sleep quality compared to standard splints, thus making a significant contribution to orthopedic medicine, postoperative rehabilitation, and patient quality of life.


Eligibility criteria:
inclusion criteria: * patient undergoing arthroscopic rotator cuff repair surgery confirmed by clinical diagnosis and preoperative imaging tests. * patient able to understand the instructions for using the brace. * patient able to perform activities of daily living with or without a brace, ensuring proper use of the brace. * patient affiliated with or beneficiary of a social security system * french speaking patient, having signed an informed consent form exclusion criteria: * patient with an uncertain diagnosis * patient undergoing rotator cuff revision surgery. * patient with complex or surgical fractures of the shoulder, humerus, or ribs * patient with multiple fractures, open fractures, or those with pinning * patient who has undergone multiple surgeries in the last 6 months. * patient with shoulder pathologies unrelated to the rotator cuff, such as severe arthritis or capsulitis. * patient on long-term morphine treatment * patient with known allergies to splint materials * protected patient: adult under guardianship, curatorship, or other legal protection, deprived of liberty by judicial or administrative order * pregnant woman * patient hospitalized without consent * patient already enrolled and participating in another clinical study
'single hand used intubating laryngoscope evaluation' study

Conditions: Respiratory Failure; Cardiac Arrest; Difficult Intubation; Anesthesia Intubation Complication

Summary: this is a study to compare the new shuttlescope with the standard macintosh laryngoscope

following a 5 minutes workshop with an instructor structured demonstration and practice with both devices, the participants attempt intubation in a normal airway scenario with the macintosh laryngoscope and the novel shuttlescope®, in a manikin model.

Eligibility criteria:
inclusion criteria: * medecine students from the basque country university (upv/ehu) exclusion criteria: * other operators different from the ones described above * previous experience with shuttlescope videolaryngoscope * informed consent non available

Keywords: airway management videolaryngoscope mannequin endotracheal intubation