Kornimate/medical-research-clean huggingface dataset:
spinal cord stimulation pioneering analgesia for resilient recovery in post intra-thoracic surgery pain

Conditions: Pain, Postoperative; Neuropathic Pain

Summary: this study aims to determine the effectiveness of spinal cord stimulation in patients with post intra-thoracic surgery pain syndrome in a placebo-controlled, crossover, randomized clinical trial.

post intra-thoracic surgery pain syndrome (ptps) is a debilitating condition marked by persistent neuropathic pain in the surgical incision area for at least 2 months after the initial procedure. proper pain control is instrumental in allowing patients to ambulate and breathe normally, without the need for splinting, and to take deep breaths necessary for effective coughing. the most common surgeries leading to ptps are video-assisted thoracoscopic surgery (vats) and (open) thoracotomy. the prevalence of ptps has been reported between 5-70%, underscoring the high risk of severe chronic postoperative pain associated with thoracic surgery. spinal cord stimulation (scs), known for its efficacy in neuropathic pain of any origin, emerges as a potential solution. scs can be regarded as an effective, safe, well-tolerated, and reversible treatment for severe drug-refractory neuropathic pain. while chronic pain guidelines strongly recommend scs for certain conditions, such as persistent pain following spinal surgery, it is not typically listed as an option for ptps. scs appears promising for treating ptps, particularly when a patient is resistant to other treatments and driven by neuropathic mechanisms. the potential for sustained pain relief, improved quality of life, and the prospect of reducing or discontinuing medication suggest that scs may significantly impact the daily lives of individuals suffering from ptps. this study aims to determine the effectiveness of scs, which involves the placement of an implantable pulse generator connected to electrodes with leads that stimulate the spinal cord, in patients with ptps. the hypothesis is that scs leads to a reduction from baseline in the severity of pain in the numeric rating scale (nrs) score, as well as an improvement in quality of life.

Eligibility criteria:
inclusion criteria: * diagnosis of post intra-thoracic surgery pain syndrome * medically fit for neurosurgery * informed consent exclusion criteria: * previous spinal cord stimulation * uncontrolled psychiatric comorbidities and substance abuse * electrical or other devices that preclude implantation of a spinal cord stimulator device * lack of informed consent

Keywords: spinal cord stimulation post intra-thoracic surgery pain syndrome
a retrospective, observational chart review of biologics in monotherapy versus the combination biologic plus methotrexate in patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: this cross-sectional, non-interventional, retrospective chart review will compare the efficacy and safety of biologic monotherapy and biologic and methotrexate combination therapy in patients with rheumatoid arthritis who have had an inadequate response to prior treatment with disease-modifying anti-rheumatic drugs including methotrexate. data will be collected from patients who have been on first-line biologic treatment for at least 6 months.


Eligibility criteria:
inclusion criteria: * adult patients, \>/= 18 years of age * diagnosis of rheumatoid arthritis by a rheumatologist * patients who have responded inadequately to methotrexate or disease-modifying anti-rheumatic drugs (dmards) and are being prescribed a biologic in monotherapy or in combination with methotrexate and other classical dmards as per nice guidelines exclusion criteria: * primary diagnosis of a condition other than rheumatoid arthritis * current treatment with a biologic in combination without methotrexate * prior treatment with an experimental agent for rheumatoid arthritis
a study of dvs sr in treatment of children and adolescent outpatients with mdd

Conditions: Major Depressive Disorder

Summary: this is a double-blind study evaluating desvenlafaxine succinate (dvs sr) sustained release vs placebo in the treatment of children and adolescent outpatients with major depressive disorder (mdd).


Eligibility criteria:
inclusion criteria: * age \>=7 and \<18 years of age * primary diagnosis of major depressive disorder (mdd) * cdrs-r score \>40 exclusion criteria: * history of suicidal behaviour, or requires precaution against suicide * not in generally healthy medical condition * history of psychosis or bipolar disorder * seizure disorder

Keywords: major depressive disorder mdd depression
efficacy and ventilatory responses to vhi in atelectasis patients

Conditions: Atelectasis

Summary: the purpose of this study include (1) to investigate the efficacy of ventilator hyperinflation technique to re-expand lung atelectasis on patients with critical trauma who intubated and mechanical ventilation in the intensive care unit, (2) to investigate the effectiveness of ventilator hyperinflation technique to improve airway clearance on patients with critical trauma in the intensive care unit, and (3) to explore the acute responses of ventilatory functions to ventilator hyperinflation technique on patients with critical trauma who intubated and mechanical ventilation in the intensive care unit.


Eligibility criteria:
inclusion criteria: * critical trauma patients with pulmonary complications who were intubated and mechanical ventilation and have a diagnosis of lobar atelectasis and/or plate-like atelectasis (atelectasis demonstrated on chest x-ray) will be considered for inclusion. for the sign of plate-like atelectasis will be persist on chest x-ray for 2 day * the injuries may occur alone or combination of these injuries: 1) head injury, 2) chest injuries, including broken ribs, with or without hemothorax, pneumothorax and hemopneumothorax with intercostal chest drainage (icd), 3) blunt abdominal, and 4) fracture of the limbs and/or spine. exclusion criteria: * acute respiratory distress syndrome (ards) * acute lung injury (ali) * pulmonary contusion * undrained pneumothorax, hemothorax, and hemopneumothorax * bronchospasm * pulmonary bullae/blebs * lung tumors * lung abscess * haemoptysis * mean arterial pressure (map) \<70 mmhg * positive end expiratory pressure (peep) \>6 cmh2o * heart rate (hr) \>140 beats/min * blood pressure (bp) \ 180/100 mmhg * restlessness * oxygen saturation (spo2) \<90% * spontaneous respiratory rate (rr) \>35 beats/min

Keywords: lung collapse ventilator hyper inflation hemodynamic responses ventilatory responses trauma patients
mechanisms of exacerbation of asthma

Conditions: Asthma

Summary: the purpose of this study is to identify the causes of asthma that were not previously suspected, to better understand the effects of inhaled steroids on asthma and to identify new way to treat asthma.

in this study, we will explore mechanisms of exacerbation in asthma by careful characterization studies in asthmatics presenting in acute severe exacerbation. specifically, we will determine the frequency of secretor status in these subjects by blood and saliva testing, and we will also perform a detailed cellular and biochemical analysis of their airway secretions. we will collect airway secretions using two methods. one method will be to have subjects cough sputum into a clean plastic container. the other method only applies to asthmatics with near-fatal asthma requiring intubation and mechanical ventilation. in these asthmatics, we will collect airway secretions by tracheal aspirate using methods normally applied in their clinical care.

Eligibility criteria:
inclusion criteria: 1. male and female subjects with a history of asthma between the ages of 18 to 75 years. 2. physician diagnosis of asthma. 3. currently experiencing an acute exacerbation of asthma. this exacerbation may be severe necessitating treatment in the emergency room, icu, or hospital ward. 4. ability to provide informed consent. exclusion criteria: 1. lung disease other than asthma. 2. females who are lactating or who are pregnant. 3. use of recreational drugs in the 1 month preceding the study.
resistance training on growth factors

Conditions: Cognitive Function

Summary: the goal of this clinial trial study is to explore the effect of high or low intensity resistance training (lirt) under similar training volume on change in serum levels of bdnf, igf-1, vegf, irisin, and plasma hcy in young adults.the main questions it aims to answer are: 1. whether high and low intensity will increase the serum levels of bdnf, igf-1, vegf, irisin, and reduce plasma hcy. 2. whether a greater magnitude of change would be suffer in low intensity group when compared to high intensity group, as an effect of greater physiological adaptation produced by more repetitions required to complete. participants will performe two different intensity resistance training (hirt, at 80%1rm with 12 repetitions and 4-5 sets and lirt, at 40%1rm with 24 repetitions and 4-5 sets). researchers will compare the training effects of two different training on these growth factors.


Eligibility criteria:
inclusion criteria: * age between 18 to 30 years * no experiencing musculoskeletal disorders or sports injuries * had not participated any regular aerobic endurance or resistance training with in the previous half years * no smoking habit or intake alcohol and other medication (e.g., steroid hormone) * good general body condition without any chronic diseases (e.g., osteoarthritis, metabolic syndrome or arthritis) exclusion criteria: * experiencing musculoskeletal disorders or sports injuries in recent 1 month * had regular resistance training exercise * intake any supplementary(drug and hormone)

Keywords: neurotrophic growth factors igf-1 bdnf vegf irisin hcy
robot-assisted rehabilitation after hiv-associated stroke: botswana

Conditions: HIV/AIDS; Stroke

Summary: today, nearly 37 million people are living with hiv (plhiv) worldwide and 30 to 40% of them will have neurologic complications leading to disability. our long-term working hypothesis is that an effective solution for increasing rehabilitation access in botswana and improving functional outcomes of plhiv having experienced a stroke with or without hiv uses an affordable robot and mobile health technologies to create a cost-effective intervention strategy. for this project, we test the feasibility of affordable robot therapy.

we will test the feasibility of affordable robot therapy in three aims. in aim 1, we will optimize for the botswana context, an affordable technology-based robot system with four exercise stations. we will optimize a prototype of our provisionally patented robot gym system, rehab cares, for therapy. optimization will include increasing cost-effectiveness, utilizing more local resources and manufacturing, and using mobile health android platforms for games and data acquisition. in aim 2, the efficiency of the newly modified robot system compared to standard of care will be assessed using 30 patients who have experienced a stroke, with or without hiv, will be recruited from those who are being treated by princess marina hospital (pmh) and living in the surrounding community. they will receive therapy using the robot gym system and receive standard of care. we will assess functional outcomes including motor impairment, function, and quality of life. the study outcomes would then inform rehabilitation practices for plhiv with stroke, with or without hiv, and suggest that affordable technology-mediated rehabilitation can reduce their motor dysfunction and resulting long-term disability.

Eligibility criteria:
inclusion criteria: * diagnosis of stroke (at least 3 months post incident) with or without hiv, age over 18; * medically stable (able to tolerate therapy and given the determination as able to go through protocol by physician); * have neurological function between 5 and 24 as defined by the nih stroke scale (nihss); * have no less than moderate cognitive function as defined by the international hiv-dementia scale * able to give consent. exclusion criteria: * unable to give consent; * severely depressed (becks depression inventory-fast screener); * experiencing excessive pain (visual analog scale (vas) score greater than 4); * have severe spasticity ( than 3) in muscle tone in elbow/shoulder/wrist hip/knee/ankle using the ashworth scale; * have total paralysis or muscular contractures of upper or lower extremity; * have a history of psychiatric disorder or cardiac problems; * have a history of prior brain injury including lesions to the cerebella or brain stem; * have open lesions on the upper or lower limbs; * it is up to the physician to decide if a subject should be excluded due to severe drug and/or alcohol abuse or taking of medication that would impair cognitive ability.
assessment of international normalized ratio (inr) prolongation in patients treated simultaneously with warfarin and cephalosporins

Conditions: Venous Thrombosis; Pulmonary Embolism; Atrial Fibrillation

Summary: many drug interactions with warfarin are well documented in the literature, including interactions with a variety of antibiotics. however,in mamy cases it is difficult to predict when the interaction remains theoretical and when it becomes clinically significant and will be reflected in the individual patient. this study's aim is to identify and characterize related conditions (including comorbidities, laboratory test results and other parameters related to the patient)that might be predictors for drug interactions turning from theoretical to clinically significant.


Eligibility criteria:
inclusion criteria: * patients aged 18 and over * patients treated with a combination of warfarin and cephalosporins * patients who were hospitalized in the department of internal medicine * patients who were treated with warfarin without cefalosporins exclusion criteria: * patients on warfarin who did not actually receive the drug during their hospitalization * patients whose medical records were not accessible or didn't contain full data
crestal vs lateral sinus lift augmentation

Conditions: Edentulous Alveolar Ridge; Bone Atrophy, Alveolar

Summary: the aim of this randomised controlled trial (rct) of split-mouth design was to compare patient preference and effectiveness of two different techniques for lifting the maxillary sinus: the crestal approach versus the lateral window approach.

each patient having bilateral edentulism in posterior maxillae was randomised to receive one partial fixed prosthesis supported by one to three implants placed either with a crestal or with lateral window sinus lift procedure. eligibility criteria for participants only healed implant sites were considered (at least 3 months after tooth extraction). the vertical bone height at the implant sites to be included had to be between 2 to 6 mm and bone thickness at least 6 mm as measured on cone-bean computed tomography (cbct) scans. patients were not admitted in the study if any of the following exclusion criteria was present: general contraindications to implant surgery subjected to irradiation in the head and neck area immunosuppressed or immunocompromised treated or under treatment with intravenous amino-bisphosphonates poor oral hygiene and motivation untreated periodontal disease uncontrolled diabetes pregnant or lactating substance abusers psychiatric problems unrealistic expectations lack of opposite occluding dentition/prosthesis in the area intended for implant placement acute or chronic infection/inflammation in the area intended for sinus augmentation/implant placement referred only for implant placement who cannot be rehabilitated and followed at the treatment centre unable to attend a 5-year post-loading follow-up. smokers were included and patients were categorised into three groups according to what declare: i) non-smokers; ìì) moderate smokers, if smoking up to 10 cigarettes/day; iii) heavy smokers if smoking more than 10 cigarettes/day. patients were recruited and treated in one private practice in tirana, albania by two operators: marco tallarico who performed all surgical interventions and erta xhanari who performed all prosthetic and maintenance procedures.

Eligibility criteria:
inclusion criteria: * partially edentulous patient * bilateral edentulism in posterior maxillae (premolars and molars) * 18 years or older * able to understand and sign an informed consent. * at least 3 months after tooth extraction * vertical bone height at the implant sites between 2 to 6 mm * bone thickness at least 6 mm as measured on cbct scan exclusion criteria: * general contraindications to implant surgery * subjected to irradiation in the head and neck area * immunosuppressed or immunocompromised * treated or under treatment with intravenous amino-bisphosphonates * poor oral hygiene and motivation * untreated periodontal disease * uncontrolled diabetes * pregnant or lactating * substance abusers * psychiatric problems * unrealistic expectations * lack of opposite occluding dentition/prosthesis * acute or chronic infection/inflammation * augmentation/implant placement * referred only for implant placement

Keywords: dental implants maxillary sinus augmentation crestal approach
prediction algorithms for the detection of early stage pancreatic cancer

Conditions: Pancreatic Cancer; Pancreatic Ductal Adenocarcinoma (PDAC)

Summary: conduct a prospective study to assess the accuracy of a pancreatic cancer risk prediction model.

the goal of this study is to establish a platform for development and implementation of a data-driven risk model for detection of early stage pancreatic cancer within an integrated health care setting. patients at increased risk for pancreatic cancer as identified by the risk model will be invited to participate in a prospective study to assess the accuracy of this approach for detection of early stage pancreatic cancer.

Eligibility criteria:
inclusion criteria: 1. patient must have 6 months of membership 2. patient has a measure for weight, hemoglobin a1c, and alanine transaminase (alt) within the past 6 months 3. patient must have an increased predicted 18-month risk of pancreatic cancer based on the pro-tect model 4. speaks english or spanish exclusion criteria: 1. previous or current history of pancreatic cancer 2. metastatic cancer 3. current active cancer or undergoing chemotherapy for cancer 4. currently pregnant or breastfeeding 5. class iv heart failure 6. cirrhosis with ascites and/or varices 7. currently in a skilled nursing facility or under hospice care 8. has metal parts or implanted devices in the body, such as a pacemaker, defibrillator, or shrapnel 9. end stage renal disease 10. cognitive impairment such that the person is unable to provide informed consent
intravenous versus oral iron therapy in hemodialysis patients

Conditions: Hemodialysis Complication; Anemia; Iron Deficiency Anemia

Summary: this study is aim to compare the efficacy of intravenous versus oral iron therapy regarding the hemoglobin levels, iron status and erythropoietin dosage in maintenance hemodialysis patients

run-in phase: all eligible patients will enter run-in phase for 2 weeks. in this phase, all oral therapy that patients received before enrolment into the study will be discontinued. masking: opened label allocation: block of four randomization into 2 treatment arms: intravenous iron and oral iron safety criteria: study participants who meet the following criteria will be discontinued from the study. all patients data will be analyzed according to intention-to-treat principles. * hemoglobin levels \< 6.0 g/dl * packed red cells transfusion is required * serum ferritin \>1,000 md/dl

Eligibility criteria:
inclusion criteria: * age \>18 years * hemodialysis for at least 3 months * hemoglobin levels between 8 and 11.5 g/dl inclusive * transferrin saturation (tsat) \<50% and ferritin \<800 mg/dl * stable dose of epoetin of any types and iron therapy for at least 1 month exclusion criteria: * history of iron allergy * pregnant or lactating women * patients with known hematologic disorders other than anemia of renal disease and iron deficiency anemia * patients with hemoglobinopathy e.g., thalassemia * patients with iron overload or hemochromatosis * patients with gastrointestinal hemorrhage during 6 months before enrolment in to the study * patients with current severe infection * patients with any malignancies * patients with severe psychiatric illness * patients with any other medical condition which, in the investigator's judgment, may be associated with increased risk to the subject or may interfere with study assessments or outcomes * patients who currently receive medications that can altered gastrointestinal absorption of oral iron e.g., aluminum carbonate, aluminum hydroxide, chloramphenicol, dimercaprol

Keywords: iron therapy hemodialysis iron status epoetin dose intravenous iron oral iron
surgery versus endoscopic resection for incompletely removed early colon cancer

Conditions: Treatment Side Effects; Colorectal Cancer

Summary: randomized head-to-head comparison trial among patients who have undergone incomplete endoscopic resection of early colon cancer to evaluate the benefits, harms and burdens, as well as the ecological footprint and cost-effectiveness of endoscopic full thickness resection (eftr), a minimally invasive endoscopic treatment with a colonoscope, as compared to standard-of-care surgery. co-primary endpoints are * rate of severe adverse events classified as grade iii to v according to the clavien dindo classification within 30-days after study treatment * crc recurrence or sign of lymph nodes or distant metastases at 3 years after randomization comparing the two treatment groups (eftr versus surgery).


Eligibility criteria:
inclusion criteria: * men and women, age 40 years or older with endoscopic removal (snare or forceps polypectomy; endoscopic mucosal resection (emr) or endoscopic submucosal dissection (esd) with r1 (resection margin \<0.1mm23,40) or rx resection margins of colon cancer (location proximal to the rectum (12 cm or more from the anal verge)) * no contraindication for colon surgery as deemed by the multidisciplinary tumor board (mtb) at the participating centre * absence of the following histopathological tumor features: poor differentiation, lymphovascular invasion, tumor budding grade b2-b3. * no sign of disease beyond stage t1n0m0 on standard-of-care computed tomography imaging of the thorax, abdomen and pelvis41 and clinical evaluation * identifiable resection site with colonoscopy, either by visualizing a previously administered tattoo or by identification of a scar in the correct colon segment * no other tumors or polyps larger than 10 mm in diameter in the colorectum at time of randomization * complete colonoscopy with adequate quality of bowel preparation (boston bowel preparation scale score ≤2 in all colonic segments) and photo or video documentation of the appendiceal orifice or ileocecal valve. * no colonic strictures or severe diverticulosis. * no prior crc * no other malignant disease which is not deemed cured * no confirmed or suspected genetic cancer syndrome (10 or more adenomas/serrated lesions, adenomatous or serrated polyposis syndrome; lynch or lynch-like syndrome) * no inflammatory bowel disease * written informed consent provided by before enrolment exclusion criteria: * all who do not fulfill inclusion criteria