Kornimate/medical-research-clean huggingface dataset:
same-day restart of b/f/taf in hiv patients after nnrti discontinuation

Conditions: HIV Infection; HIV

Summary: in china, free first-line art regimens typically consist of two nucleoside reverse transcriptase inhibitors (nrtis) and a non-nucleoside reverse transcriptase inhibitor (nnrti). as of the end of 2022, approximately 1.135 million individuals were receiving art, achieving a coverage rate of 92.8%, largely due to participation in free treatment programs. however, around 36,000 patients have discontinued treatment, primarily due to side effects associated with efavirenz (efv), a common nnrti. the challenges posed by side effects and resistance profiles of existing nnrtis highlight the need for effective re-initiation of art to improve overall treatment coverage. instis, particularly b/f/taf (bictegravir/emtricitabine/tenofovir alafenamide), demonstrates effective viral suppression and a higher barrier to resistance than nnrtis. b/f/taf has shown efficacy in patients with resistance mutations, making it a strong candidate for same-day art re-initiation, especially in resource-limited areas where genotypic resistance testing may be unavailable. this study aims to evaluate the feasibility and effectiveness of rapidly restarting b/f/taf in patients with treatment interruptions from previous nnrti regimens.


Eligibility criteria:
inclusion criteria: * patients with 18 years old or above. * discontinuation of previous nnrti based regimen for more than 90 days. * no known crcl\< 30ml/min or severe hepatic impairment. * no known or suspected resistance to bic. * no known pregnancy exclusion criteria: ••patients who are pregnant. * patients who have abnormal liver and kidney function indicators(child-pugh class c, crcl\< 30).hepatitis virus co-infection does not serve as an exclusion criterion. * patients who have historic resistance test indicating drug resistant to bic or baseline resistance test indicating resistance to bic. * patients who are psychiatric illness or active tuberculosis co-infection.

Keywords: hiv hiv infection
thrombus composition in ischemic stroke: analysis of the correlation with plasma biomarkers, efficacy of treatment, etiology and prognosis

Conditions: Stroke, Acute; Biological Specimen Banks; Biomarkers; Etiology; Prognosis

Summary: the recent validation of thrombectomy in addition to thrombolysis with intravenous administration of alteplase suggests a major revolution in the management of acute strokes. this treatment option also opens up a new field of research, making possible the analysis of the clot responsible for intracranial occlusion. indeed, in about 30% of the cases, the thrombectomy procedure makes it possible to retrieve either partially or completely the clot. previous studies have analyzed the correlation between the composition of the thrombus and the etiology of stroke. their discordant results do not yet make it possible to distinguish a particular profile of thrombus according to etiology. other studies have shown a correlation between the proportion of red blood cells in a thrombus and the likelihood that it is visible in mri or cerebral scanning. more recently, one study has demonstrated a correlation between the presence of lymphocytes in the thrombus and an atheromatous etiology. the main limitations of these studies are the small number of patients included, the high variability of conservation protocols and the absence of plasma data, which does not allow for research on the correlation between clot composition and plasma biomarkers.


Eligibility criteria:
inclusion criteria: * patient aged 18 years and older; having a cerebral infarction following arterial occlusion; treated by thrombectomy; patient in whom a thrombus could be collected. exclusion criteria: * patient benefiting from a legal protection measure; pregnant or breastfeeding woman
improving the diagnostic of tuberculosis

Conditions: Tuberculosis

Summary: the presence of m. tuberculosis in non-invasive throat swabs of patients withdrawn for suspected tuberculosis. hypothesis 10% of patients infected by m. tuberculosis are carrier of m. tuberculosis pharyngeal. secondary 1. measure the time to diagnosis of pulmonary tb by comparing the sample versus noninvasive pharyngeal samples taken routinely. 2. evaluation of the direct cost of the diagnosis of m. tuberculosis by comparing the sample versus noninvasive pharyngeal samples taken routinely. 3. beijing genotype prevalence among patients with pulmonary tuberculosis.


Eligibility criteria:
inclusion criteria: * patient taken for microbiological examinations "kit mycobacterium" * patient major (\> 18 years). * patient who freely signed the informed written consent. * patient affiliated to a system of social security. exclusion criteria * patient minor (\<18 years). * patient pregnant or nursing. * major patient under guardianship. * private patient liberty or under court order. * patient refusing to sign the informed consent form.
development and evaluation of functional probiotic powder in human trials

Conditions: Exercise Fatigue

Summary: purpose: to optimize the preparation process of probiotic powder and assess its impact on healthy athletes, providing a scientific basis for functional foods. procedures: probiotic powder preparation: using vacuum freeze-drying to improve bacterial survival rates. human trials: recruiting healthy athletes aged 20-30, divided into placebo and probiotic powder groups for an 8-week trial. testing and analysis: conducting running exhaustion tests and blood biochemical analysis to evaluate the effects of probiotic powder. importance: understanding the effects of probiotics on athletes helps develop better health products.


Eligibility criteria:
inclusion criteria: * age range: individuals aged 20 to 30 years old. * health status: healthy, without chronic illnesses or disabilities. * athletic background: well-trained athletes with a history of regular physical activity. * lifestyle: no history of smoking or excessive alcohol consumption. * compliance and consent: capable of understanding and adhering to study protocols and willing to provide informed consent. exclusion criteria: * chronic illnesses: individuals with unmanaged chronic diseases * substance use: current smokers or individuals with a history of substance abuse. * allergies and supplements: history of food allergies or long-term use of nutritional supplements and medications. * probiotic and antibiotic use: use of probiotics, fermented products, or antibiotics during the study period. * other conditions: pregnant or breastfeeding women, individuals with severe mental health conditions, or those participating in other clinical studies.
kogenate fs regulatory post-marketing surveillance

Conditions: Hemophilia A

Summary: to obtain data on safety, efficacy, and tolerability of kogenate fs under real-life conditions in its registered indications. the observation period for each patient is up to 6 months.


Eligibility criteria:
inclusion criteria: * patients with diagnosis of hemophilia a * treated with kogenate fs as their only source of fviii, decision taken by the investigator to administer kogenate fs * signed the informed consent form to participate in this study. * for pretreated patients with more than 100 exposure days an inhibitor assessment within three months prior to enrollment should be available * for pretreated patients with less than 100 exposure days an inhibitor assessment at baseline should be available * for patients with no available inhibitor status, it should be checked as per the recommendation of kfda * patients are defined as included in the study if there is a documented prescription of kogenate fs by the physician. exclusion criteria: * patients with hypersensitivity to any ingredient of kogenate fs or to the protein of mouse or hamster will be excluded.

Keywords: kogenate fs hemophilia a
non-surgical treatment of peri-implantitis with and without erythritol air-polishing

Conditions: Peri-Implantitis

Summary: erythritol is a natural sugar alcohol (a four-carbon polyol) produced by the reduction of erythrose. it is considered safe as food additive and has many of the functional properties that are important for subgingival debridement. current evidence includes no prospective studies comparing the outcomes of a low abrasive erythritol air-polishing as an adjunctive therapy to conventional titanium and ultrasonic debridement of patients in a maintenance program with peri-implantitis. thus, the main purpose of this randomized, single-masked controlled trial (rct) is to assess whether low abrasive erythritol air-polishing has an adjunct effect to conventional non-surgical treatment of peri-implantitis.

this rct will enroll subjects among patients in need for non-surgical treatment of peri-implantitis at a private dental clinic in stavanger, norway. forty patients diagnosed with peri-implantitis on at least one implant will be randomly allocated by tossing a coin into test or control group. patients with cement-retained and screw-retained supraconstructions will be included. treatment of peri-implantitis will be performed by one operator (as) at baseline, 3-, 6-, 9- and 12-month follow-up visits. local anesthesia will be used when needed. in the test group, implants will be treated with titanium curette, ultrasonic device and a specially designed nozzle mounted on a hand piece (perio-flow) connected to an airflow unit. in the control group, implant with peri-implantitis will be debrided with titanium curette and ultrasonic device only. test and control debridement will be performed without time limit. the treatment will continue until the operator is judging the implant surface to be free for supra- and subgingival deposits.

Eligibility criteria:
inclusion criteria: * healthy subjects aged 20 - 85 years who have received one or more dental implant(s) being in successful function for more than 12 months and restored with an optimal supraconstruction * diagnosed with peri-implantitis based on the following criteria: * bleeding and/or suppuration upon gentle probing * increased probing depths (pd) compared with previous examinations or pd of ≥ 4 mm in at least one site around the implant * crestal bone level (cbl) loss ≥2 mm compared with baseline registration exclusion criteria: * surgical treatment of peri-implantitis the last 6 months * supportive periodontal therapy within 3 months * use of systemic antibiotic within 6 months * a history of non-compliant behavior * inflammation around implant without evidence of bone loss * periapical peri-implantitis * subjects with implant fracture, ceramic implants, or detectable subgingival cement * any current medical condition affecting the use of the abrasive air-polishing device. * subjects with diabetes mellitus, cancer, hiv/aids, acute infections, liver or kidney dysfunction/failure, * current pregnancy or breastfeeding

Keywords: peri-implantitis air-polishing erythritol
effects of thermotherapy on chronic neck pain

Conditions: Neck Pain

Summary: chronic neck pain is a common worldwide problem. in the majority of cases, patients are treated by medication, referral to a physiotherapist or thermotherapy. thermotherapy - the therapeutic application of topical heat - provides an easy to apply self-help strategy in patients with chronic neck pain. however, despite the frequent use in clinical practice, there is no research regarding this topic yet. the aim of this study was to evaluate whether thermotherapy self-treatment for chronic neck pain induces changes in perceived pain intensity and in sensory processing.


Eligibility criteria:
inclusion criteria: * non-specific neck pain the last 3 months * mean pain intensity of at least 4 on a 10-level numerical rating scale with "0" meaning "no pain" and "10" meaning "worst pain imaginable" exclusion criteria: * radicular symptoms * congenital spine deformity * skin diseases in the painful area to be treated * pregnancy * insulin-dependent diabetes mellitus * rheumatic diseases * oncologic diseases * steroid medication * anticoagulation medication * recent invasive or surgical treatment of the spine

Keywords: hyperthermia, induced randomized controlled trial neck pain sensory thresholds pain measurements
effect of fully blocking type 1 angiotensin receptor on target organ damage of postmenopausal hypertensive women

Conditions: Hypertension

Summary: this study compared the improvements of blood pressure levels, left ventricular hypertrophy, left ventricular diastolic function, vascular function and cognitive function between postmenopausal hypertensive women and age-matched hypertensive male patients through the evaluation of the effects of fully blocked at1 receptor by valsartan. additionally, the differences of the above indexes between the patients who were fully blocked at1 receptor by valsartan and the patients who were treated with a single dose of valsartan treatment were assessed, so as to provide theory basis for clinical treatment of postmenopausal hypertensive women.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of hypertension * women are all postmenopausal * must provide written informed consent exclusion criteria: * secondary hypertension * coronary disease * heart failure * arterial fibrillation * previous myocardial infarction * previous stroke * malignant disease * kidney failure * liver failure * neoplastic disease * severe neurological diseases * severe metabolic or organic decompensation * refuse to sign the informed consent form

Keywords: hypertension left ventricular hypertrophy women
comparison of 4l polyethylene glycol and 2l polyethylene glycol with ascorbic acid in inactive uc patients

Conditions: Ulcerative Colitis

Summary: the purpose of this study is to compare preference of the patients, efficacy of preparation, and safety between 4 l polyethylene glycol and 2 l of polyethylene glycol with ascorbic acid in patients with inactive ulcerative colitis.


Eligibility criteria:
inclusion criteria: * age \>18 years old * ulcerative colitis patients without symptoms for at least 1 year * ulcerative colitis patients who undergo colonoscopy for surveillance exclusion criteria: * subjects who had abdominal surgery * pregnant or breast feeding

Keywords: ulcerative colitis bowel preparation
quetiapine in postpartum depression

Conditions: Postpartum Depressive Disorder

Summary: the purpose of the study is to evaluate the efficacy and tolerability of quetiapine in female patients with postpartum depressive disorder with psychotic symptoms


Eligibility criteria:
inclusion criteria: * provision of signed informed consent. * female patients with severe postpartum depressive disorders with psychotic symptoms and a minimum ham-d cut off score of 20 points exclusion criteria: * woman with pre-existing psychotic disorder * patients with alcohol or substance abuse or dependence * patients who pose an imminent risk of suicide or danger to self or others

Keywords: postpartum depression quetiapine psychotic symptoms
clinical study of dmt in healthy adults

Conditions: Healthy Volunteers

Summary: this study aims to evaluate the acute and subacute effects of an inhaled n, n-dimethyltryptamine in healthy individuals.

participants will receive n, n-dimethyltryptamine administered in two dosing sessions: an initial low-dose safety session and subsequent intermediate-dose treatment, in a fixed order and 2h apart.

Eligibility criteria:
inclusion criteria: * prior experience with n,n-dimethyltryptamine (dmt) * present proof of vaccination against covid-19 (coronavírus) exclusion criteria: * heart failure * liver failure * kidney failure * resistant hypertension * arrhythmia * valvular heart disease * chronic obstructive pulmonary disease * asthma * severe obesity * epilepsy * pregnancy * thyroid disorders * family diagnosis or suspicion of genetic monoamine oxidase deficiency * previous adverse response to psychedelic substances * present or past symptoms or family members with a psychotic disorder * dissociative identity disorder * bipolar disorder * prodromal symptoms of schizophrenia * abuse of alcohol or other psychoactive substances, except tobacco * acute or sub-acute risk of suicide * flu-like symptoms

Keywords: n,n-dmt dmt n,n-dimethyltryptamine healthy volunteers
drug use investigation of gabapentin

Conditions: Epilepsies, Partial

Summary: the objective of the this surveillance is to collect information about 1)adverse drug reactions not expected from the lpd (unknown adverse drug reactions), 2) the incidence of adverse drug reactions in this surveillance, and 3) factors considered to affect the safety and/or efficacy of this drug.

all the patients whom an investigator prescribes the first gabapentin should be registered consecutively until the number of subjects reaches target number in order to extract patients enrolled into the investigation at random.

Eligibility criteria:
inclusion criteria: patients need to be taking gabapentin in order to be enrolled in the surveillance exclusion criteria: patients not taking gabapentin

Keywords: post-marketing surveillance
skeletal muscles, myokines and glucose metabolism myoglu

Conditions: Hyperglycemia; Normoglycemia; Myokine

Summary: normal glucose uptake and metabolism in skeletal muscles are essential to keep blood glucose within normal range and hence, insulin resistance (possibly mediated by inflammatory processes) in skeletal muscle is a major pathogenic factor in type 2 diabetes. physical activity seems to be of essential importance in the prevention and treatment of type 2 diabetes. myokines are proteins secreted from skeletal muscle that can execute important biological functions locally in the muscle (paracrine) or in other organs like the brain, heart and pancreas (endocrine). evidence suggest that several interleukines and other cytokines are secreted by skeletal muscles. in the present project, the investigators will explore the relation between secreted myokines from muscle cells, insulin resistance and glucose metabolism before and after 12 weeks of exercise intervention. subjects with normal as well as impaired glucose metabolism will be included in the study.


Eligibility criteria:
inclusion criteria: * male * age 40-65 years * nordic ethnicity * non-smoker 1. either (participants with impaired glucose metabolism): body mass index (bmi) 27-32 kg/m2 and abnormal glucose metabolism, defined as: i. impaired fasting glucose (fpg ≥ 5.6 mmol/l) ii. impaired glucose tolerance (2 h pg ≥7.8 mmol/l) iii. type 2 diabetes (no medication, hba1c ≤7.5%) 2. or (controls): bmi 19-25 kg/m2 and normal glucose metabolism and no first degree relatives with type 2 diabetes. exclusion criteria: 1. subjects having type 1 diabetes or medically treated type 2 diabetes. 2. systolic blood pressure ≥ 160 mmhg or diastolic blood pressure ≥ 90 mmhg at screening 3. significant hematological or renal disease or chronic renal impairment, gfr\< 50 ml/min. 4. significant liver disease or alat \>3x unl. 5. chronic inflammatory disease in active phase or long-term use of corticosteroids last 3 months. 6. use of anti-diabetic agents, lipid lowering drugs, antihypertensive medication, asa or any other drug not deemed suitable by the study physician. 7. mental condition (psychiatric or organic cerebral disease), drug or alcohol abuse rendering the subject unable to understand the nature, scope and possible consequences of the study. 8. bmi outside inclusion criteria. 9. smoker 10. any medical or other condition that in the judgment of the investigator would jeopardize the subject's safety or evaluation of the intervention for efficacy and safety 11. exercising regularly (\>1 times pr week)

Keywords: myokine insulin sensitivity exercise skeletal muscle
leucine enriched essential amino acid mixture to reverse muscle loss in cirrhosis

Conditions: Cirrhosis, Liver

Summary: loss of skeletal muscle mass or sarcopenia is the most common and potentially reversible complication in cirrhosis that increases morbidity and mortality before, during and after liver transplantation. no proven treatments exist for the prevention or reversal of sarcopenia in cirrhosis, primarily because the mechanisms responsible for this are unknown. based on compelling preliminary studies and those of the co investigator, investigators hypothesize that the mechanism of reduced skeletal muscle mass in cirrhosis is due to a myostatin mediated impaired mtor (mechanistic target of rapamycin) signaling resulting in reduced protein synthesis and increased autophagy. investigators further postulate that leucine, a direct stimulant of mtor, will reverse the impaired mtor phosphorylation in the skeletal muscle of cirrhotics. the consequent increase in protein synthesis reduced autophagy will result in an increase in skeletal muscle mass. investigators will test these hypotheses by quantifying the response to acute and long term (3 month) administration of leucine enriched essential amino acid (eaa/leu) compared with an isonitrogenous isocaloric non-essential balanced amino acid mixture (does not stimulate protein synthesis) in cirrhotic patients. fractional protein synthesis rate (fsr) in skeletal muscle, responses of the molecular regulatory pathways of skeletal muscle protein synthesis, and autophagy flux will be quantified in the acute and long term protocols. tracer studies using l-\[d5\]-phenylalanine (phe) as a primed constant infusion (prime 2µmol.kg-1.hr-1; constant 0.05 µmol.kg-1.hr-1) with and l \[ring-d2\] tyrosine, forearm plethysmography, and sequential skeletal muscle biopsies (total of 3 per study subject) will be used to quantify these outcomes. anthropometric, clinical and body composition measures will be additional outcome measures for the long term intervention. expression of regulatory signaling proteins, myostatin, igf-1 (insulin like growth factor) , phospho-akt, phospho-ampk (activated protein kinase), phospho-mtor and phospho-p70s6k will be quantified by western immunoblots. autophagy flux will be measured by quantifying expression of the autophagosome proteins.


Eligibility criteria:
inclusion criteria: * cirrhotic patients: * cirrhosis diagnosed by liver biopsy and/or clinical, biochemical and imaging evidence of cirrhosis. * abstinence from alcohol and/or other recreational drugs for at least 6 months * child's pugh score 5-9 (inclusive). exclusion * cirrhotic patients: * child's score \>9 * pedal edema above the ankle * presence of concurrent illnesses (renal, cardiac, pulmonary, cerebrovascular, malignancy) or medication (anabolic steroids, corticosteroids) intake that affect skeletal muscle mass. * diabetes mellitus * active gastrointestinal bleeding * sepsis, encephalopathy * renal failure * hepatocellular carcinoma outside of milan criteria * unwilling to sign informed consent or follow research procedures * does not meet inclusion criteria
urogenital infections in women of reproductive age and the activity of 4-thiazolidinone derivatives against pathogens

Conditions: Bacterial Vaginosis

Summary: research concerning women pathogenic microflora during different conditions

study of microflora of different groups of women of reproductive age, determination of pathogens and their further study, samples of a newly synthesized compound on isolated pathogens

Eligibility criteria:
inclusion criteria: * urogenital infections, pregnancy exclusion criteria: * healthy microflora