Kornimate/medical-research-clean huggingface dataset:
early assessment of ovarian cancer aggressiveness by metabolic imaging

Conditions: Ovarian Cancer

Summary: to learn if an mrsi can be performed on a 3t scanner using an investigational contrast drug called hyperpolarized 13-c pyruvate. 3t refers to the "strength" of the mri machine.

primary objective: 1. to assess if increased lactate production measured by hp 13c mri occurs in suspected ovarian cancer patients who will undergo surgery 2. to evaluate the proportion of increased lactate production in the ovaries measured by hp 13c mri in low/high ovarian cancer risk patients. secondary objectives: 1. correlate hp-mr findings to metabolomics, immune profiles, and blood biomarkers of patients undergoing surgical resection. 2. demonstrate the feasibility and utility of metabolic imaging with hp 13c pyruvate mr in patients with suspected ovarian cancer 3. correlating imaging findings such as enhancement pattern, adc values, and advanced image analytics such as texture with pathology and genetic analysis for patients who will undergo surgical resection.

Eligibility criteria:
inclusion criteria: for the first cohort, the following selection criteria will be applied who are undergoing a screening exam at md anderson: 1. patients with a first degree relative (mother, sister, or daughter) with ovarian cancer or 2. a personal history of breast cancer before age 40 or 3. a personal history of breast cancer diagnosed before age 50, and one or more close relatives diagnosed with breast or ovarian cancer at any age. two or more close relatives diagnosed with breast cancer before age 50 or with ovarian cancer diagnosed at any age or 4. ashkenazi jewish heritage and a personal history of breast cancer before age 50 or 5. ashkenazi jewish heritage and a first- or second-degree relative diagnosed with breast cancer before age 50 or with ovarian cancer at any age or 6. presence of a brca1 or brca2 mutation or 7. presence of a mismatch repair gene mutation associated with a hereditary cancer syndrome known as hereditary non-polyposis colon cancer (hnpcc)/lynch syndrome. for the second cohort- 10 patients will be enrolled who present to md anderson for a pelvic ultrasound or have an outside ultrasound or imaging study without a mass or have an adnexal mass (benign) on outside imaging and do not have a high risk for ovarian cancer. for the third cohort of patients: 10 patients who have suspicion of ovarian malignancy on conventional imaging and will be undergoing surgical resection will be included. exclusion criteria: (all cohorts) 1. children, pregnant women, cognitively impaired adults, or prisoners will be excluded from participation.
ai-aided optical coherence tomography for the detection of basal cell carcinoma

Conditions: Basal Cell Carcinoma; Optical Coherence Tomography

Summary: basal cell carcinoma (bcc) is the most common form of cancer among the caucasian population. a bcc diagnosis is commonly establish by means of an invasive punch biopsy (golden standard). optical coherence tomography (oct) is a safe non-invasive diagnostic modality which may replace biopsy if an oct assessor is able to establish a high confidence bcc diagnosis. hence, for clinical implementation of oct, diagnostic certainty should be as high as possible. artificial intelligence in the form of a clinical decision support system (cdss) may improve the diagnostic certainty of newly trained oct assessors by highlighting suspicious areas on oct scans and by providing diagnostic suggestions (classification). this study will evaluate the effect of a cdss on the diagnostic certainty and accuracy of oct assessors.

in this diagnostic case control design, oct assessors will retrospectively evaluate oct scans of equivocal bcc lesions twice (once with, and once without the help of the cdss). a total of 124 scans (62 bcc/62 non-bcc) will be included in the study. cases will be shuffled to prevent recall bias. ai-aided oct scans and unaided oct scans will be presented in alternating order. the assessors will express their certainty level on a 5-point confidence scale. the diagnostic certainty and diagnostic accuracy of oct assessment with cdss and without cdss will be compared. research questions: 1. does ai-aided oct assessment result in an increase in high-confidence diagnoses compared to unaided oct assessment? 2. does ai-aided oct assessment result in a significant increase in sensitivity for bcc detection without compromising specificity compared to unaided oct assessment? 3. does ai-aided oct assessment result in more accurate bcc subtyping compared to unaided oct assessment (explorative)

Eligibility criteria:
inclusion criteria: * patients (18+ years) * patient underwent oct scan and punch biopsy for an equivocal bcc lesion exclusion criteria: - patient unable to sign informed consent

Keywords: basal cell carcinoma bcc optical coherence tomography oct imaging artificial intelligence machine learning
a study to evaluate the effects of a single-dose and repeat-administration of intranasal esketamine on on-road driving in participants with major depressive disorder

Conditions: Depressive Disorder, Major

Summary: the primary purpose of this study is to evaluate the effect of a single 84-milligram (mg) dose of intranasal esketamine compared to placebo, on next day driving performance and repeated administration of 84 mg intranasal esketamine on same-day driving performance as assessed by the mean difference of standard deviation of lateral position (sdlp) from an on-road driving test.


Eligibility criteria:
inclusion criteria: * willing and able to adhere to the prohibitions and restrictions specified in this protocol * if a woman, must have a negative serum beta human chorionic gonadotropin pregnancy test at screening and a negative urine pregnancy test on day 1 of period 1 in part a and prior to study drug administration in part b * comfortable with self-administration of intranasal medication and able to follow instructions provided * normal visual acuity (corrected or uncorrected) * based on self-report, able to consume an amount of alcohol that typically produces a blood alcohol concentration (bac) of 0.05 percent (that is, 2 to 3 alcoholic drinks ingested within 2 hours on a single occasion) exclusion criteria: * current or prior diagnosis of psychosis/psychotic or bipolar disorder * primary sleep disorder, such as insomnia, requiring pharmacological intervention at screening * clinically significant abnormal values for hematology, clinical chemistry, or urinalysis at screening or day 1 of period 1 as deemed appropriate by the investigator * clinically significant abnormal physical examination, vital signs, or 12-lead electrocardiogram (ecg) at screening or day 1 of period 1 as deemed appropriate by the investigator * history of moderate or severe use disorder according to diagnostic and statistical manual of mental disorders (dsm-iv or dsm-5) criteria within 1 year before screening or positive test result(s) for alcohol and/or drugs of abuse (such as barbiturates, opiates, cocaine, cannabinoids, amphetamines, and benzodiazepines) at screening and day 1 of period 1
gefitinib 500mg versus 250mg in patients with nsclc with stable disease after a month treatment of gefitinib 250mg

Conditions: Non-small Cell Lung Cancer

Summary: this is a multi-center phase ii randomized controlled study to assess the efficacy of gefitinib 500mg in patients with iiib/iv staged non-small cell lung cancer(nsclc) with stable disease after a month treatment of 250mg gefitinib by dcr,also pfs and os.the side effect is evaluated as well.


Eligibility criteria:
inclusion criteria: 1. histologically or cytologically confirmed stage iiib/iv lung cancer(exclude patients confirmed by sputum cytology) 2. received at least one chemotherapy regimen 3. with stable disease after a month treatment of gefitinib(ct scan) 4. the radiotherapy focus is not the measurable disease within 4 weeks.the patients received palliative therapy can be included. 5. age \>18 years, either sex 6. with a measurable disease(longest diameters \>=10mm with spiral computed tomography (ct)and \>=20mm with conventional ct) at least according to recist criteria 7. who performance status(ps)\<= 2 ( patients whit ps=2 should not get worsen within 2 weeks before included) 8. n\>=1.5×109/l, plt\>=1.5×109/l,hb\>=10g/dl 9. alp\ =2.5uln, ast\&alt should \<1.5uln(without liver metastasis) or \<5uln(with liver metastasis).tbil\<=1.5uln，ast\&alt\<2.5uln(without liver metastasis) or \<5uln (with liver metastasis). 10. signed and dated informed consent before the start of specific protocol procedures. 11. recruiting and receiving treatment in 5 days after last ct scan 12. patients able to taken oral drug exclusion criteria: 1. life expectancy \<= 12 weeks.patients with metastatic brain tumors without symptoms or had been treated can be included. 2. experience of anti-egfr(the epidermal growth factor receptor) monoclonal antibody or small molecular compounds therapy such as erlotinib or cetuximab. 3. can not take drug orally, have active peptic ulcer,half upper gastrointestinal or have dyspepsia. 4. allergic to gefitinib 5. prior exposure to drugs without approval from this research or other study drugs within 21days before the 1st day taken gefitinib 500mg or 250mg. 6. pregnant or breast-feeding women 7. severe systemic disease out of control such as unstable or uncompensated respiratory,cardiac,liver,renal diseases. 8. previous or concurrent cancer that is distinct in primary site or histology from the cancer being evaluated in this study except of cervical carcinoma in situ,basal cell carcinoma within 5 years prior to study entry.
the effect of an inpatient home-work exercise program on leg function after stroke

Conditions: Cerebrovascular Accident (Stroke)

Summary: this study would focus on a new method of adding extra leg homework exercises to the usual therapy delivered in the hospital. we propose to design an exercise program for the affected leg that would be given to the client as homework and done in the client's hospital room or ward. the program would be designed and monitored by a therapist that works in the hospital.

in total 120 participants admitted for stroke rehabilitation in the province british columbia, canada will be randomly assigned to either the leg exercise group or leg management group. the extra leg exercise group (experimental group) will receive usual therapy plus 60 minutes per day of self-directed leg exercises. this program will last for 4 weeks while the participant is in the hospital. the leg exercise program will include exercises of range of motion, leg strengthening, weight-bearing, and walking. the family will be encouraged to participate in the program with the participant. the control group (leg management group) will receive usual therapy and stroke education.

Eligibility criteria:
inclusion criteria: * have been admitted to a hospital unit for stroke treatment * 19 years or older * are experiencing difficulty using legs * able to understand and follow instructions exclusion criteria: * have uncontrolled hypertension or unstable cardio-vascular condition * injuries to muscles, bones, or joints of the leg * unable to verbally speak or understand the investigators when asked questions

Keywords: exercise rehabilitation leg function in patient rct
effectiveness of two compression methods in the treatment of upper limb lymphedema

Conditions: Lymphedema

Summary: treatment of lymphedema is based on a combined program called complex decongestive therapy. the components of the complex decongestive therapy are skin care, kinesiotherapy, manual lymphatic drainage and compression. the compression with multilayer bandage has proved to be the most effective of these therapies when analyzed separately.the multilayer bandage produces a gradient compression on the limb where distal pressure is higher than proximal pressure. several materials are needed for the multilayer bandage, including tubular bandage lining, digit bandages, foam under-cast padding and multiple layers of short-stretch bandages to cover the entire limb. the precast adjustable compression wrap fits each patient through a velcro system. the aim is to compare the effectiveness of a precast adjustable compression wrap (circaid) with the multilayer compression bandages in the treatment of the upper limb lymphedema.

the gold standard of the treatment of lymphedema is based on a combined program called complex decongestive therapy. the components of the complex decongestive therapy are skin care, kinesiotherapy, manual lymphatic drainage and compression. the compression with multilayer bandage has proved to be the most effective of these therapies when analyzed separately. with the multilayer compression bandage the upper limb lymphedema volume decreased a 37.2%. the multilayer bandage produces a gradient compression on the limb where distal pressure is higher than proximal pressure. several materials are needed for the multilayer bandage, including tubular bandage lining, digit bandages, foam under-cast padding and multiple layers of short-stretch bandages to cover the entire limb. the precast adjustable compression wrap fits each patient through a velcro system. decreasing compression is achieved by controlling the tension applied to each velcro through a visual color guide. the precast adjustable compression wrap has proved to be safe and effective to treat lower limb lymphedema, but there is little information about its effectiveness in the treatment of the upper limb lymphedema. the aim is to compare the effectiveness of a precast adjustable compression wrap (circaid) with the multilayer compression bandages in the treatment of the upper limb lymphedema.

Eligibility criteria:
inclusion criteria: * upper limb lymphedema after axillary lymph node dissection for breast cancer. * lymphedema must affect at least the arm or the forearm. * the lymphedema volume excess must be at least 10% * the lymphedema must have not been previously treated or have been at least 1 year without treatment. exclusion criteria: * bilateral upper limb lymphedema * cognitive or sensorial impairments which could interfere collaboration * plexopathy post radiotherapy * breast cancer in progression pregnancy or lactation

Keywords: upper limb lymphedema
comparison of rabeprazole and esomperazole for the eradication of h. pylori

Conditions: H. Pylori Infection

Summary: patients infected with h. pylori are treated with rabeprazole 10 mg bid, ampc 750 mg bid and cam 200 mg bid or esomeprazole 20 mg bid, ampc 750 mg bid and cam 200 mg bid. eradication rates are compared. patients who have ever failed in eradication by cam-based regimen are treated with rabeprazole 10 mg bid, ampc 750 mg bid and mnz 250 mg bid or esomeprazole 20 mg bid, ampc 750 mg bid and mnz 250 mg bid.

patients infected with h. pylori are treated with rabeprazole 10 mg bid, ampc 750 mg bid and cam 200 mg bid or esomeprazole 20 mg bid, ampc 750 mg bid and cam 200 mg bid. eradication rates are compared. patients who have ever failed in eradication by cam-based regimen are treated with rabeprazole 10 mg bid, ampc 750 mg bid and mnz 250 mg bid or esomeprazole 20 mg bid, ampc 750 mg bid and mnz 250 mg bid. cyp2c19 genotypes and susceptibility to cam are genetically measured. other factors are also analyzed with reference to eradication rates.

Eligibility criteria:
inclusion criteria: * patients infected with h. pylori who can undergo the eradication therapy exclusion criteria: * patients with severe other disorders, cannot undergo eradication therapy, refuses to participate to the study.

Keywords: eradication rates rabeprazole esomeprazole
evaluation of effectiveness for connected network for ems comprehensive technical-support using artificial intelligence (connect-ai) system by community intervention

Conditions: Emergency Patient Transported by Ambulance

Summary: this study aims to verify the effectiveness of the connected network for ems comprehensive technical-support using artificial intelligence (connect-ai) system through demonstration in the local community. the study was designed as a prospective non-random cross-intervention study design in two preselected communities. the subjects of the study are patients transferred to the local emergency department(ed) through an ambulance of a fire department in the selected community. if the storage and transmission of information collected by an ambulance fails or the information of the transferred patient cannot be verified in the transferred ed, it is excluded from the study. in this study, the developed connect-ai system was installed in all emergency vehicles and eds in two regional cohorts, and the effectiveness was measured by operating an intersection for the same period. the primary outcome is the transfer time spent in the pre-hospital stage, and the secondary outcome is whether the optimal transfer hospital is selected.


Eligibility criteria:
inclusion criteria: * patients transferred to the local emergency department(ed) through an ambulance of a fire department in the selected community. exclusion criteria: * if the storage and transmission of information collected by an ambulance fails or the information of the transferred patient cannot be verified in the transferred ed
conventional and molecular diagnostic method for patients with suspected uti

Conditions: Urinary Tract Infections-UTI

Summary: in this protocol, the investigators are examining the use of a novel pathogen testing technology and method of identification of antibiotic susceptibility against the conventional c \& s testing for patients with both complicated and uncomplicated utis. the investigators will examine the two modes in terms of objective patient related outcomes, i.e. 1) diagnostic accuracy and degree of detail of final analysis; 2) time to resolution of symptoms; 3) quality of life as defined by particularly symptomology and "bothersomeness" of the symptoms; and 4) overall cost.


Eligibility criteria:
inclusion criteria: * • age greater than or equal to 18 and less than or equal to 89 years. * the pi suspects the patient has a complicated or uncomplicated uti that requires urine testing to confirm diagnosis * able to provide at least 8 ml urine total (urine for 2 pathology tests). * is willing to complete one follow up surveys and send back to fh. exclusion criteria: * • unable or unwilling to provide written informed consent. * unable to read and write english (surveys are not available or validated in any other language than english). * currently on any antibiotic for any clinical indication.
cognitive motor dual task versus task specific training on cognition and motor functioning in stroke patients

Conditions: Stroke

Summary: this study focuses on dual task training as daily living involves many dual task conditions, in which a person requires to do two or more tasks at same time. without the ability to carry out these types of dual movements. this study aims to improve the ability to do two tasks at same time, targeted to decrease the risk of fall in stroke patients. this study helps in understanding how multiple tasks simultaneously affects patients' abilities and creating effectiveness programs.

the world health organization (who) defines the stroke as a brain injury that causes rapid and noticeable changes in cerebral function, lasting 24 hours or longer, or resulting in death. strokes can be caused by vascular issues and include cerebral infarction, intracerebral hemorrhage, and subarachnoid hemorrhage. stroke is a syndrome characterized by acute neurological deficits caused by vascular injury in the central nervous system. it's a major cause of disability and mortality globally, resulting from various risk factors, diseases, and mechanisms. dual-task training refers to the ability to simultaneously perform multiple cognitive and motor activities while maintaining postural control. divided attention is the capacity to do more than one thing at the same time. dual-task training innovatively combines motor and cognitive rehabilitation in a comprehensive module. tst, or task-specific training, is a popular rehab approach that emphasizes function and is commonly used for stroke patients. it's all about targeting specific tasks to help with recovery. rct conducted on two groups, dual task training and task specific training. interventions applied with a frequency of three times a week for eight weeks protocol. participants will be divided into 2 groups. 1st group will receive dual task training for motor and cognition simultaneously. 2nd group will receive task specific training for motor and cognition functioning.

Eligibility criteria:
inclusion criteria: * patients with age ≥ 45 years' old both male and female. * patients with mild cognitive impairment with moca score of 18-25. * patients with sub-acute or chronic stage of stroke and are able to sit * independently for 30 secs. * patients with primary level education. exclusion criteria: * patients with dementia that had been diagnosed by a neurologist. * patients with neurological, psychiatric, or medical disorders. * patients with auditory or visual impairments.

Keywords: cognition, motor functioning, stroke
urdu version of lower extremity functional scale: reliability and validity study

Conditions: Musculoskeletal Disorder

Summary: the objective of the research is to translate and to culturally familiarize the lower extremity functional scale into the urdu language along the investigation if the lower extremity functional scale is reliable and validate in the pakistani population with lower extremity musculoskeletal disorders and to check the correlation with short form - 36.

the questionnaire will be translated into urdu and cross-culturally modified. internal consistency, test-retest reliability, conceptual validity, discriminative validity, responsiveness, and concurrent validity will be examined in 150 participants seeking treatment for lower extremity dysfunction using the urdu version of the lower extremity functional scale.

Eligibility criteria:
inclusion criteria: * from16 years old to 60 years old * presence of an lower extremity musculoskeletal disorders like soft tissue injuries, joints and muscles injuries * no intervention between the test-retest assessments exclusion criteria: * to complete the forms because of a psychological impairment. * illiteracy or lack of understanding of urdu language * the presence of any kind of bone fracture

Keywords: lower extremity functional scale musculoskeletal disorder cultural adaptation validity urdu version reliability lower extremity