Kornimate/medical-research-clean huggingface dataset:
evaluation of self-reported walking impairment in predominantly illiterate patients

Conditions: Diabetes

Summary: the purpose of this study is to test the routine feasibility of an image tool adapted from the welch questionnaire ( walking estimated limitation calculated by history) to estimate walking impairment (the welsh questionnaire: walking estimated limitation stated by history) in patients investigated for walking impairment. secondary aims correlation with the maximal walking distance.

the welsh is self completed by the patients and scored by the physician after self-completion. patients perform a 6 minutes walking test on a 30m corridor

Eligibility criteria:
inclusion criteria: * •signed consent for the data treatment as a database exclusion criteria: * rebuttal to participate

Keywords: walking impairment disability diabetes mellitus
magnesium balance of citrate-based continuous venovenous hemofiltration, effect of citrate dose.

Conditions: Critically Ill; Acute Kidney Injury

Summary: rationale: a higher citrate dose during continuous venovenous hemofiltration provides better anticoagulation but possibly a higher risk of citrate accumulation in case of metabolic limitations. a higher citrate dose also increases magnesium loss in ultrafiltrate, while a negative magnesium balance is unwanted. objective: aim of this study is to determine the magnesium balance of citrate-based continuous veno-venous hemofiltration (cvvh) and to determine whether and to which extent the magnesium balance depends on citrate dose. study design and methods: a prospective randomized study conducted in critically ill patients with acute kidney injury (aki), treated with cvvh, with either low dose citrate (2.5 mmol/l blood flow in the filter) or high dose citrate (4.5 mmol/l blood flow in the filter) as anti-coagulant, targeting a postfilter ionized calcium (ica) of resp. 1.3-1.6 mg/dl (0.325-0.4 mmol/l) and 0.8-1.1 mg/dl (0.2-0.275 mmol/l). post-filter blood as well as effluent aliquots and bloodconcentrations in the patient are tested for the following variables: (0 , 2 , 4, 6, 12 and 24 hrs): total magnesium (tmg) and total calcium (tca), ionized ca (ica)(bloodgas analyzer). in addition, hematocrit, albumin, total protein, ureum and creatinine and parathormone (pth) are determined in arterial blood at 0 and 24 hrs or at the time of protocol exit and citrate concentrations in postfilter and arterial blood at 1 and 24 hrs or at protocol exit. sample sites: arterial line, postfilter port (after postdilution and calcium compensation), effluent sample. all flow rates to be noted. study population: twenty patients admitted to intensive care, requiring continuous renal replacement therapy (crrt) for aki. intervention: anti-coagulation with either low dose citraat (2.5 mmol/l blood flow) or high dose citraat (4.5 mmol/l blood flow) targeting postfilter ica of resp. 1.3-1.6 and 0.8-1.1 mg/dl. both regimens are within standard protocolled cvvh treatment in the intensive care department.


Eligibility criteria:
inclusion criteria: * critically ill patients requiring crrt for aki (rifle criteria) * written informed consent from the patient or legal representative exclusion criteria: * pre-existing chronic renal insufficiency requiring dialysis * chronic immunosuppression * liver cirrhosis child-pugh c * severe or shock-related hepatitis * pregnancy
mantle irradiation for hodgkin's disease

Conditions: Hodgkin's Disease

Summary: the purpose of this study it to evaluate the effectiveness of radiation therapy limited to above the diaphragm in patients with pathological stage ia-iia hodgkin's disease.

* eligble patients will receive a course of radiation therapy directed to above the diaphragm only. * patients would have bloodwork and chest x-rays performed 4 times per year for the first two years, 3 times per year for the third year, and 2 times per year for the fourth and fifth years. after five years, yearly check-ups are performed. * in addition to the above follow-up, patients will receive, once or twice a year for the first 5 years, an abdominal-pelvic ct scan and/or gallium scan.

Eligibility criteria:
inclusion criteria: * pathologically stage ia-iia hodgkin's disease * a negative staging laparotomy including splenectomy, biopsies of liver, paraortic nodal biopsies and palpitation of upper pelvic nodes * 18 years of age or older exclusion criteria: * patients with large mediastinal adenopathy * patients with ld histology * patients with "b" symptoms * positive laparotomy * subcarinal, hilar, or cardiac lymph node involvement

Keywords: hodgkin's disease stage ia-iia mantle irradiation
tap block , intrathecal morphine or their combination for post operative analgesia following tah

Conditions: Post-operative Pain Management

Summary: this randomized controlled clinical trial designed to evaluate the efficacy of transversus abdominis plane (tap) block, intrathecal morphine, or their combination in postoperative pain relief, as assessed by time to first analgesic request, pain scores, total postoperative analgesic consumption, time of ambulation, complications and hemodynamics following total abdominal hysterectomy.


Eligibility criteria:
inclusion criteria: * female patients aged 30 to 70 years. * elective total abdominal hysterectomy. * asa physical status i or ii. * willingness to provide informed consent. exclusion criteria: * refusal of the block. * allergy to study medications. * preexisting coagulation disorders. * local infection at the site of needle insertion. * uncontrolled respiratory or cardiac disorders. * impaired kidney or liver function.
delaying alzheimer disease symptoms with anti-inflammatory drugs

Conditions: Alzheimer Disease; Dementia

Summary: the purpose of this study is to determine whether the anti-inflammatory drug celecoxib can delay the onset of alzheimer disease (ad) in people with age associated memory impairment (aami). this study will also evaluate genetic risk and brain structure as potential predictors of mental decline.

ad is one of the most common mental disorders of late life. preliminary studies indicate that anti-inflammatory drugs may attenuate or prevent ad symptoms, but efficacy trials are needed. participants in this study will be randomly assigned to receive either celecoxib or placebo for 18 months. participants will undergo positron emission tomography (pet) and magnetic resonance imaging (mri) scans of the brain. routine laboratory blood tests, cognitive tests, and an electrocardiogram (ecg) will be performed. participants will also be screened for parkinson disease. follow-up testing will be conducted at specific intervals following the study.

Eligibility criteria:
inclusion criteria: * nimh diagnostic criteria for age associated memory impairment (aami) * mini-mental state examination (mmse) score between 26 and 30 (unless \< 8 years of educational achievement) * no significant cerebrovascular disease * estrogen replacement therapy and thyroid replacement therapy (if the participant is euthyroid) are permitted if the therapies are stable for \> 1 month * memory and verbal fluency cut-off scores that increase the probability of incipient dementia (buschke-fuld: 34; verbal fluency: 46 for letters, 7 for categories; benton visual retention: 5) * adequate visual and auditory acuity to allow neuropsychological testing * normal screening laboratory tests and electrocardiogram (ecg) exclusion criteria: * possible or probable alzheimer disease (ad) or other dementia * neurologic or other physical illness that could produce cognitive deterioration * history of transient ischemic attacks (tias), carotid bruits, or lacunes on an mri scan * history of myocardial infarction within the previous year or unstable cardiac disease * uncontrolled hypertension (systolic bp \> 170 or diastolic bp \> 100) * history of significant liver disease, pulmonary disease, diabetes, or cancer * dsm-iv criteria for major psychiatric disorders within the previous 2 years * past or present history of alcoholism or drug dependence * untreated depression as determined by a hamilton depression rating scale (ham-d) score of 12 or more * drugs that may significantly affect psychometric test results * centrally active beta-blockers, narcotics, clonidine, anti-parkinsonian medications, antipsychotics, benzodiazepines, systemic corticosteroids, medications with significant cholinergic or anticholinergic effects, anti-convulsants, warfarin, vitamins other than the standard multivitamin supplement, ginkgo biloba, and any nutraceuticals. occasional chloral hydrate use will be allowed, but discouraged, for insomnia. * investigational drugs within the previous month or longer, depending on drug half-life * contraindication for mri scan (e.g., metal in body, claustrophobia)
clinical observation of long-term efficacy and safety of glycyrrhizic acid preparation in the therapy of autoimmune liver disease

Conditions: Autoimmune Liver Disease

Summary: this study was a retrospective clinical observation cohort study. all patients with autoimmune liver disease treated with glycyrrhizic acid preparations in the department of liver diseases, department of liver diseases, beijing ditan hospital, capital medical university, were enrolled. clinical follow-up data including demographics, hematuria, and liver and kidney were collected. functional, electrolyte blood glucose, pta, erythrocyte sedimentation rate, serum afp and other clinical biochemical indicators and autoantibodies, special proteins and liver imaging (liver ultrasound) examination. the clinical effect of glycyrrhizic acid preparation for the treatment of autoimmune liver disease for 144 weeks and the safety during treatment were analyzed.

this study was a retrospective clinical observation cohort study. all patients with autoimmune liver disease treated with glycyrrhizic acid preparations in the department of liver diseases, department of liver diseases, beijing ditan hospital, capital medical university, were enrolled. clinical follow-up data including demographics, hematuria, and liver and kidney were collected. functional, electrolyte blood glucose, pta, erythrocyte sedimentation rate, serum afp and other clinical biochemical indicators and autoantibodies, special proteins and liver imaging (liver ultrasound) examination. the clinical effect of glycyrrhizic acid preparation for the treatment of autoimmune liver disease for 144 weeks and the safety during treatment were analyzed.

Eligibility criteria:
inclusion criteria: * 1) patients with autoimmune liver disease: all enrolled autoimmune liver diseases meet the diagnostic criteria of china's consensus on diagnosis and treatment of autoimmune liver disease (2015); * 2) no hormones and / or immunosuppressants and other liver protection drugs; * 3) sign the written informed consent form. exclusion criteria: * 1) combine other hepatitis virus (hcv, hdv) infections; * 2) viral liver disease; * 3) hiv infection; * 4) long-term alcohol abuse and / or other liver damage drugs; * 5) mental illness; * 6) evidence of liver tumors (liver cancer or afp \> 100 ng/ml); * 7) decompensated cirrhosis; * 8) serious diseases such as heart, brain, lung, kidney, etc. can not participate in long-term follow-up; * 9) there are hormones and / or immunosuppressants and other liver protection drugs.

Keywords: autoimmune liver disease glycyrrhizic acid liver function
comparison of the treatment outcomes of the conventional stainless steel crown restorations and the hall technique in the treatment of carious primary molars

Conditions: Caries,Dental

Summary: stainless steel crowns have shown high success in restoring carious primary molars over a longer period of time than conventional restorations. this study aims to evaluate the treatment effectiveness of conventional sscs restoration and hall technique in treating carious primary molars


Eligibility criteria:
inclusion criteria: 1. agree and voluntarily participate in the research (with the patient's parent/guardian consent for participation) 2. children have a primary molar with at least 2 carious lesions corresponding to international caries detection and assessment system (icdas) scores 4 or at least 1 carious lesion corresponding to icdas scores 5 and 6. exclusion criteria: 1. children with systemic diseases such as immunodeficiency, cardiovascular disease, or bleeding disorders. 2. children are allergic to nickel and resin. 3. children unable to return for recall visits. 4. primary molar has signs of pulpal/periapical diseases (irreversible pulpitis, pulp necrosis, loosening, fistula, or abscess). 5. children are undergoing orthodontic treatment with fixed or removable appliances.

Keywords: dental caries primary molars stainless steel crowns
eus guided coil embolization for primary prophylaxis of gastric varices

Conditions: Gastric Varices Bleeding

Summary: the standard treatment of bleeding gastric varices is obliteration with placement of coil and glue. our study will evaluate the efficacy of eus guided coil as primary prophylaxis for high-risk gastric varices. all procedures will be performed with patient under deep sedation or general anaesthesia under the supervision of an anaesthesiologist.

in this study principal investigator recruiting patients with high-risk gastric varices for primary prophylaxis. gastric varices are dilated submucosal veins in the lining of the stomach, found in patients with portal hypertension or elevated pressure in the portal venous system. the standard treatment of bleeding gastric varices is obliteration with placement of coil and glue. our study will evaluate the efficacy of eus guided coil as primary prophylaxis for high-risk gastric varices. all procedures will be performed with patient under deep sedation or general anaesthesia under the supervision of an anaesthesiologist. after the procedure patients will be discharged to home unless there is any indication for admission, such as significant abdominal pain, bleeding or chest pain. for enrolment into the study, patient has to sign an informed consent form which is provided at the end. first, we will do baseline evaluation of the patient which includes detailed clinical examination, routine laboratory tests, upper gi endoscopy, triphasic ct abdomen. the duration of study is 6 months. only the routine tests necessary for the management of disease will be charged.

Eligibility criteria:
inclusion criteria: - each patient must meet all the following criteria to be enrolled in this study: 1. gastric fundal varices larger than 2.0 cm in total diameter 2. high risk gv (gov 2/igv 1) 3. primary prophylaxis 4. patients with known fundal varices 5. ability to give a signed informed consent exclusion criteria: - the exclusion criteria for these volunteers will be: 1. patients with a history of tips or any other portosystemic shunt procedure 2. oesophageal stricture 3. patient not fit for general anaesthesia 4. secondary prophylaxis 5. pediatric patients (\<18 years) 6. pregnant or lactating mother 7. not willing to participate
efficacy study of izn-6d4 gel for the treatment of diabetic foot ulcers

Conditions: Diabetic Foot Ulcer

Summary: the purpose of this study is to determine if topical application of a hydrogel that contains plant extracts will improve healing of diabetic foot ulcers when compared to treatment with a hydrogel alone.

this is a multi center, double-blind, randomized, placebo-controlled trial. a total of 80 patients will be randomized according to a 1: 1 randomization schedule. to participate in the trial, patients must have a current diabetic foot ulcer (dfu) for between 60 days to 2 years at the screening visit. in the 2-week period between screening and baseline visit, the patient's dfu must not have healed by 30% or more, in wound area, while being treated with swt twice a week during this screening period. during the treatment period of 4 weeks all patients will be examined on a weekly basis by the site staff. treatment with swt plus the study gel (izn-6d4 gel or placebo gel) (including any necessary debridement) will be administered at these weekly visits. in addition, the patient or caregiver will be trained to perform swt plus the study treatment at home once midweek between visits.

Eligibility criteria:
inclusion criteria: * current diagnosis of diabetes mellitus type 1 or 2 * foot ulcer wagner grade 1 or 2 * ulcer between 1 square cm and 8 square cm present for at least 60 days and not more than two years * hgba1c less than 10% * able to comply with all procedures exclusion criteria: * wound area decrease of greater than 30% between screening and baseline visits * gangrene on any part of the affected foot * pregnancy or lactation

Keywords: diabetes chronic wound
highly challenging balance program to reduce fall rate in pd

Conditions: Parkinson's Disease

Summary: this study will test the hypothesis that two highly challenging exercise programs, one based at the va medical center and the other conducted remotely, will both significantly reduce overall fall rates in patients with parkinson's disease.

background/rationale. parkinson's disease (pd) is the second most common neurodegenerative disease, affecting over one million americans. the cardinal clinical manifestations of pd include resting tremor, rigidity, bradykinesia, and postural instability/gait disturbance. in addition, people with pd fall frequently, with 60% falling annually and two-thirds of these falling recurrently. identifying interventions that successfully improve postural control and reduce fall rate is critical to reduce disability, improve quality of life, and potentially increase survival in patients with pd. recent randomized, controlled trials (rct) have examined the effects of exercise and physical therapy interventions on reducing falls in patients with pd; however, with mixed results. objectives. there is a limited availability of effective treatment options to reduce falls in pd. in this context, some studies suggest that highly challenging exercise approaches may lead to better outcomes. the investigators propose investigating the effects of two theoretically driven, progressive, highly challenging exercise programs: 1) a structured exercise program at the va and 2) a structured exercise program at home. there will also be a control group in which health education is provided. methods. the investigators propose to conduct an rct evaluating effects on fall rate. a total of 162 va patients with mild-to-moderate pd will be randomly assigned to one of the three 3-month interventions: in-person exercise at the va, remotely-delivered exercise, or health education. outcomes will be compared between each intervention group and the control group. fall rates will be compared between groups with the use of negative binomial regression models.

Eligibility criteria:
inclusion criteria: * physician diagnosis of idiopathic pd * at least 2 of the 3 cardinal signs of pd (resting tremor, rigidity, bradykinesia) * response to dopaminergic medication exclusion criteria: * angina pectoris * history of myocardial infarction (mi) within 6 months * history of ventricular dysrhythmia requiring current therapy

Keywords: parkinson's disease exercise therapy accidental falls
laser closure of anal fistula (filac)

Conditions: Anal Fistula; Fistula in Ano; Sphincter Ani Incontinence

Summary: laser closure of the perianal fistula is the minimally invasive and low complication rate procedure which is a life-saving way for complex fistulas, preserving anal sphincter injury. unfortunately, wide range success rate reported before (30-80%), the investigators are searching to reach better rates. internal closure of the fistula orifice offered by some authors. the investigators are aimed to identify the efficiency of this.

despite the developments in the surgical field, the treatment of anal fistula is still a challenging problem, especially in complex, transsphincteric cases. the surgical treatment aims to avoid recurrences and also to preserve normal sphincter functions. the filac procedure was recently reported non-invasive technique in perianal fistulas for treatment and preserving anal sphincter function with a good success rate. in 2018, one of our colleagues published a 40% complete healing rate by using only filac technique in 103 consecutive perianal fistula patients (prof. cem terzi). some authors advocated that the closure of the internal orifice increasing the success rate. therefore, the investigators decided to modify the surgical technique focusing closure of the internal opening associated with the filac procedure.

Eligibility criteria:
inclusion criteria: * complex anal fistula * high anal fistulas * recurrent anal fistulas exclusion criteria: * superficial anal fistulas * multibranching anal fistulas

Keywords: sphincter injury anal abscess incontinence
validity of computed tomography versus magnetic resonance imaging in predicting muscular invasion of bladder cancer

Conditions: Bladder Cancer

Summary: the aim of this work is to compare validity between ct and mri in detecting muscular invasion in patients with bladder cancer.


Eligibility criteria:
inclusion criteria: * patients with urinary bladder mass exclusion criteria: * bleeding tendency ,patients had chemo , radiotherapy
mr-guided high intensity focused ultrasound for pain management of osteoid osteoma & benign bone tumors in children and adults

Conditions: Osteoid Osteoma; Benign Bone Tumor; Pain

Summary: the philips sonalleve hifu system is expected to be efficacious in reducing pain scores in patients with painful osteoid osteoma and other benign bone tumors, and in reducing their pain medication usage. no serious adverse effects are expected to result from this treatment.

the objective of this study is to determine if mr-guided high-intensity focused ultrasound (mr-hifu) is safe and effective technique for alleviating the pain associated with osteoid osteoma and other benign bone tumors in paediatric patients and adults(up to age 40 yrs). this technique meant to be an alternative to the standard-of-care, radiofrequency and laser-based percutaneous ablation. safety of the technique will be assessed through evaluating non-targeted heating using mri based temperature mapping. and inspecting patients post treatment for skin burns or other signs of serious adverse events. efficacy of the technique will be assessed by evaluating/recording patients observed pain, quality of life, and pain medication usage both before and up to 6 months following treatment.

Eligibility criteria:
inclusion criteria: * age 5-40 years. * able to give informed consent and have parent or guardian give informed consent if applicable. * weight \<140 kg (requirement to fit safely on top of the hifu table and inside the mri). * definitive radiographic \& clinical presentation of osteoid osteoma or other benign tumor lesion(avoiding need for biopsy). * pain specifically at the site of interest target lesion. * pain score for target lesion \>/= 4 (indicating at least moderate pain) or an age-appropriate pain scale. * target lesion is uncomplicated (i.e. no fracture/spinal cord compression/cauda equina syndrome/soft tissue component). * mr-hifu treatment date \>/= 2 weeks from most recent surgical treatment of lesion. exclusion criteria: * unable to characterize pain specifically at the site of interest (target lesion). * pregnant/nursing females. * target lesion is complicated (i.e. presence of one of fracture/spinal cord compression/cauda equina syndrome/soft tissue component). * target lesion \< 1cm from neurovascular bundles/bowel/hollow viscera or regions of cartilage/ bone growth). * target lesion located in skull, spine (excluding sacrum, which is allowed) or sternum. * scar along proposed hifu beam path. * orthopaedic implant along proposed hifu beam path or at site of target tissue. * serious cardiovascular, neurological, renal or haematological chronic disease. * active infection. * contraindication to general anaesthetic or gadolinium mri contrast agent. * requirement for general anesthesia for non-hifu related mri's.

Keywords: high intensity focused ultrasound