Kornimate/medical-research-clean huggingface dataset:
self-administered acupressure for insomnia disorder

Conditions: Insomnia Chronic

Summary: the study is to evaluate the clinical effects of self-administered acupressure for treating insomnia disorder delivered by a training course. subjects will be offered either self-administered acupressure training or sleep hygiene education. their insomnia severity will be compared after 8 weeks.

objectives: to evaluate the clinical effects of self-administered acupressure for treating insomnia disorder delivered by a training course. hypothesis: subjects in the self-administered acupressure group will have greater improvement in insomnia symptoms and daytime impairment than those in the sleep hygiene education (she) group at 4 weeks and 8 weeks. design and subjects: a randomized controlled trial. 184 subjects with insomnia disorder recruited from the community will be randomized to self-administered acupressure or she groups in a 1: 1 ratio. study instrument: insomnia severity index (isi) will be used to assess insomnia symptoms and daytime impairment. interventions: subjects in the self-administered acupressure group will attend two training lessons (2-hour each) to learn self-administered acupressure and practice it every night for 4 weeks; subjects in the she group will receive sleep hygiene education with the schedule and duration that are same to the self-administered acupressure group. main outcome measures: the primary outcome measure is the isi score. other measures include sleep parameters by subjective sleep diary and objective actigraphy, hospital anxiety and depression scale, and sf-6d at 4 and 8 weeks. acceptability and compliance of self-administered acupressure will be evaluated. data analysis: differences in the questionnaire scores, subjective and objective sleep parameters will be examined using a mixed-effects model.

Eligibility criteria:
inclusion criteria: 1. chinese hong kong residents who are able to communicate in cantonese or putonghua; 2. aged 18-64 years; 3. a current clinical dsm-5 diagnosis of insomnia disorder according to the brief insomnia questionnaire (biq) 4. insomnia severity index total score of at least 10 indicating insomnia at the clinical level; and 5. willing to give informed consent and comply with the trial protocol. exclusion criteria: 1. receiving acupuncture or practitioner-delivered acupressure treatment in the past 6 months; 2. pregnancy; 3. cognitive impairment as indicated by a mini mental state examination ≤23; 4. at significant suicidal risk as rated by the hamilton depression rating scale item on suicide (score ≥3) ; 5. no comorbid sleep disorders primarily requiring other treatment, such as sleep apnea or narcolepsy; 6. taking herbal remedies, over-the-counter medication, or psychotropic drugs that target insomnia within the 2 weeks prior to baseline; and 7. shift-workers/
statin contrast induced nephropathy prevention

Conditions: Acute Coronary Syndrome

Summary: this open-label study, prospective, randomized trial evaluating the acute (in-hospital) pleiotropic and clinical effects of a hydrophilic statin (rosuvastatin) in patients with acute coronary syndrome

the primary purpose of this study is to determine whether, in patients with acute coronary syndromes not taking statins in chronic administration, high doses of a hydrophilic statin (rosuvastatin) administered before coronary angiography and/or angioplasty, may exert a renal-protective effect by reducing the incidence of contrast nephropathy. contrast induced nephropathy is defined as increased values of creatinine \>= 0.3 mg/dl from baseline values, within 72 hours after contrast medium exposure. secondary end points: 1) verify if short-term (\<48 hours)statin administration reduces the peak levels and the curve areas of markers of myocardial necrosis throughout the hospitalization period and if reduces the occurrence of periprocedural infarction. biochemical markers (quantitative creatine kinase-mb (ck-mb) mass and troponin i) are measured at admission and at 6, 12, and 24 hours during the first day then once daily, immediately before angiography, and 24 hours thereafter. in patients who underwent coronary angioplasty (pci), biochemical markers were measured at 12 and 24 hours after the procedure. data were fitted, peak values and curve areas calculated; the occurrence of periprocedural infarction was defined as a ck-mb mass elevation more than three times the upper limit of normal within 24 hours after pci. 2) determine the distribution of peripheral lymphocytic populations at the entry and at discharge using the flow cytometric analysis; 3) analyze the clinical composite outcome of death, myocardial infarction, urgent revascularization, dialysis and stroke at 30 days and 6 months.

Eligibility criteria:
inclusion criteria: are eligible for the study all patients admitted to ccu for acute coronary syndrome without st elevation (nstemi) candidates for early invasive strategy (coronary angiography within 48 hours from the admission) and without previous therapy with statins. exclusion criteria: 1. inability to provide consent 2. pregnancy or lactation 3. intolerance to statins 4. therapy with other lipid lowering drugs 5. acute or chronic liver disease 6. chronic muscle disease 7. acute renal failure or chronic renal failure stage iv 8. neoplastic 9. exposure to iodinated contrast medium in the previous 10 days

Keywords: statin cin periprocedural damage
effect of a low glycemic index diet on breast density

Conditions: Breast Cancer

Summary: this study is a pilot phase ii cancer intervention trial of a low glycemic index diet to reduce mammographic density in women at high risk for breast cancer.


Eligibility criteria:
inclusion criteria: * are between 40 and 60 years of age * still menstruating with at least 10 menstrual cycles in the previous 12 months * not taking hormone replacement therapy * stable oral contraceptive use (no changes is use in past 12 months nor changes intended during interventional period) * have not been previously diagnosed with breast cancer, dcis,lobular carcinoma in situ, atypical lobular hyperplasia or atypical hyperplasia * no history of breast augmentation or reduction surgery * have no history of any other malignancy (excluding non-melanoma skin cancer) in the previous 5 years * have no history of diabetes or other metabolic diseases requiring dietary modification * have a study baseline mammographic density of at least 50% as estimated by mammographer * birads 1 or 2 mammogram if first ever mammogram, otherwise stable mammogram (no change since previous year) * have not followed a weight reduction or atkins typs diet in the past 6 months not pregnant or lactating in the past 12 months, nor intending pregnancy during the study period * successful completion of three baseline telephone-administered 24- hour dietary recalls
college students who self-harm

Conditions: Borderline Personality Disorder; Suicide

Summary: study aims/objectives: this projects' primary aim is development of a condensed dbt stepped care model tailored to the unique requirements of students meeting sub-clinical diagnostic criteria for bpd (borderline personality disorder) with its associated high rate of self-harm and suicide.

study aims/objectives: this projects' primary aim is development of a condensed dbt stepped care model tailored to the unique requirements of students meeting sub-clinical diagnostic criteria for bpd with its associated high rate of self-harm and suicide. the investigator previously implemented a 4-mth condensed-dbt regimen with success in an adult clinical population. this study will evaluate an intensive 8 week intervention formulated for students to reduce the high prevalence of self-harm and dysfunctional behavior in this population and reduce the need for extended treatment in later years. it will include rigorous screening for collateral disorders, including substance use disorders exacerbating bpd symptoms and suicide risk.

Eligibility criteria:
inclusion criteria: * age 18 to 27 * currently enrolled in college * meet at least 4 of 9 criteria of bpd (dsm-v) with one criterion being self-harm (e.g. cut, burn, or hit self) exclusion criteria: * have a current major psychiatric disorder diagnosis, or other gross cognitive impairment (as identified in the phone screen or the scid i measure) or * have undergone dbt or * are suicidal and require full dbt and/or hospitalization or * are currently in any other individual or group therapy * unable to attend weekly visits over 8 weeks, starting march 24, 2014

Keywords: self-harm self-mutilation cutting
effects on mindfulness meditation on patient's satisfaction during urodynamic study

Conditions: Personal Satisfaction

Summary: the purpose of this investigator-initiated study is to evaluate if mindfulness-based stress reduction (mbsr) will improve satisfaction and reduce anxiety during a urodynamic study (uds).

urodynamic studies (uds) are used to measure the functionality of the bladder and urethra to be able to evaluate lower urinary tract symptoms (luts). uds consists of catheterization, uroflow and cystometrogram. intravesical, vaginal or rectal transducer placements, and placement of perineal electrodes are part of the study protocol. during the study the bladder will be filled slowly with sterile fluid and the patient will be asked about sensation of filling. at the end of the study the patient will be asked to void. although beneficial for diagnosis of underlying luts, uds maybe associated with heightened patient anxiety and feeling of discomfort. in a recently published pilot study, it was shown that a mindfulness-based stress reduction (mbsr) protocol may help improve a patient's emotional health and perception of uds. to validate the findings from this previous study, the current study aims to implement a mbsr protocol in a randomized prospective study. patients scheduled for uds will be randomized into two groups. one group will listen to mindfulness meditation prior to the uds and the other group won't. all patients will complete validated questionnaires to assess their satisfaction, anxiety and pain level as well as lower urinary tract symptoms before and after intervention.

Eligibility criteria:
inclusion criteria: * female and male patients between ages 18 and 99 with clinical indication for uds ordered by treating physician exclusion criteria: * none english speakers will be recruited for this study. * pregnancy * prioners

Keywords: meditation, urodynamics, satisfaction, pain, anxiety
cutaneous and mucosal manifestations of neurofribromatosis type 2 in children under 15

Conditions: Neurofibromatosis 2; Dermatology/Skin - Other

Summary: .neurofibromatosis type 2 is an inherently autosomal dominant genetic disease, but cases of mosaicism or de novo mutation are not uncommon. the prevalence is estimated at 1 / 60,000. the clinical presentation is based on the appearance of tumors in the central and peripheral nervous system. the current average age of diagnosis is around 25 to 30 years depending on the studies. currently, the diagnostic criteria are based on the ent, neurological and opthalmological manifestations of the disease. cutaneous manifestations have been described in these patients. except now, mucocutaneous manifestations of the disease are not taken into account for depisatage or diagnosis. the purpose of this study would be to identify the different cutaneous and mucosal manifestations in a pediatric population under 15 years of age, and to analyze whether this might be of interest in early detection of the disease in association with other symptoms.


Eligibility criteria:
inclusion criteria: * age up to 15 years * diagnosis of neurofibromatosis type 2 exclusion criteria: * refusal to participate in the study * informed consent that can not be obtained because of a disability or difficulties with a - language barrier
exploratory study of mt-1303 in systemic lupus erythematosus patients

Conditions: Systemic Lupus Erythematosus

Summary: the purpose of this study is to evaluate the safety/tolerability and to explore the efficacy of mt-1303 in subjects with systemic lupus erythematosus


Eligibility criteria:
inclusion criteria: * diagnosis of sle based on the american college of rheumatology (acr) criteria * presence of at least one of the following items: positive anti ds-dna antibodies, low complement levels, and so on. * stable doses of corticosteroids exclusion criteria: * severe active lupus nephritis, neuropsychiatric sle

Keywords: systemic lupus erythematosus
non-interventional enhanced active surveillance study of adults vaccinated with azd1222

Conditions: Coronavirus Disease 2019 (COVID-19)

Summary: this is a phase iv real-world, observational, non-interventional, prospective cohort study of adults vaccinated with azd1222. the purpose of this study is to assess the safety and tolerability of azd1222 in adults vaccinated in real-world settings.

the study will use an innovative digital platform (study app and web portal) as well as a traditional call centre to collect participant responses to a series of health and well-being questionnaires over an 18-month period. research coordinators at vaccination sites will invite vaccinated adults to join the study. participants can enrol at the vaccination site with assistance from a research coordinator or can take home a study information brochure and enrol within 28 days after the first dose of azd1222. research coordinators and the study call centre will be available to assist with enrolment and informed consent, as needed. electronic consent using the study app will be an option where permitted. participants using the digital platform will set up a secure account, complete the enrolment questionnaires, and provide details of their vaccination to confirm eligibility. non-digital participants will complete the enrolment questionnaires and confirm eligibility at a vaccination site or by a telephone call to the call centre. after enrolment, participants will be contacted to complete follow-up questionnaires at timed intervals over an 18-month period after their first azd1222 dose. digital participants will receive push notifications or emails and non-digital participants will receive phone calls. participants can also submit unscheduled adverse event (ae) reports through the digital platform and call centre.

Eligibility criteria:
inclusion criteria: * aged 18 or older at the time of vaccination. * received azd1222 as the first dose of covid-19 vaccination in the prior 28 days. * the participant has provided sufficient details to validate the vaccination (vaccination card, batch/lot number, and/or regional vaccination register details). * provided informed consent to participate in the study, either personally or through a legal representative. * able and willing to provide responses to study notifications using the mobile device app, web portal, or call centre or have a proxy (a caregiver, family member, or other trusted individual) who can do so on their behalf. * able and willing to grant, personally or through a legal representative, permission to contact the participant's healthcare providers and to access the participant's medical records at the time of vaccination and during the post-vaccination follow-up period.

Keywords: active surveillance study non-interventional post-authorisation safety studies vaccine
effectiveness of modified diaphragmatic training for gastroesophageal reflux disease post covid-19

Conditions: GERD; Post COVID-19 Condition; Diaphragm Issues

Summary: the study titled "effectiveness of modified diaphragmatic training for improving gerd-q score, diaphragmatic excursion, maximum inspiratory pressure and lung function in adults with gastroesophageal reflux disease after covid-19: a single-blinded randomized control trial" is a clinical trial that aimed to investigate the effectiveness of 4 weeks modified diaphragmatic training (mdt) compare with standard diaphragmatic training for improving gerd-q score, diaphragmatic excursion, maximum inspiratory pressure, and lung function in adults with gastroesophageal reflux disease (gerd) after covid-19. the trial was single-blinded and randomized, and it included a total of 50 participants. the results of the study showed that mdt was effective in improving gerd-q score, diaphragmatic excursion, maximum inspiratory pressure, and lung function in adults with gerd after covid-19.

the study aims to investigate the effectiveness of modified diaphragmatic training compared with standard diaphragmatic training in adults with gastroesophageal reflux disease after covid-19. the design is a single-center in a national respiratory referral center in indonesia, single-blinded randomized control trial. a central randomization center used computer-generated tables to allocate treatments. the study will involve a randomized controlled trial with a sample size of 50 adult patients with gerd after covid-19. participants will be randomly assigned to either a modified diaphragmatic training group or a control group. four weeks of training with diaphragmatic training followed by modified diaphragmatic training (mdt) or standard diaphragmatic training. follow-up 30 days

Eligibility criteria:
inclusion criteria: * male and female after recover from moderate covid-19. * six month post covid-19 * age 18 to 60 years old * gerd-q score more than 7 * agree to participate in the study * well understanding of the study procedure. exclusion criteria: * history of ventilator used while covid * history of uncontrolled cardiac problems and chronic pulmonary * pregnancy or lactation * history of surgery in the abdomen of the thoracic area * severe scoliosis or kyphotic * hiv/ aids, autoimmune * prolonged use of dyslipidemia drug more than 1 year * prolonged use of prokinetic gastric drug more than 4 weeks

Keywords: diaphragmatic training gerd-q score diaphragmatic excursion maximal inspiratory pressure lung function gerd after covid-19
short messaging service program to help quit smoking during perioperative period.

Conditions: Tobacco Use Cessation; Perioperative/Postoperative Complications; Tobacco Smoking

Summary: smoking can increase the risk of complications around the time of surgery. researchers are trying to see if a text messaging program can help smokers stay off cigarettes around the time of surgery.

the long-term goal of the project is to increase the reach and effectiveness of tobacco use interventions in healthcare settings. the main objective of this project is to determine whether an innovative tobacco use intervention targeting abstinence from the morning of surgery until one week after surgery ("quit for a bit") can increase sustained engagement of surgical patients in treatment compared with a standard tobacco use intervention that specifically targets long-term abstinence ("quit for good").

Eligibility criteria:
inclusion criteria: * age 18 years or older * greater than 100 cigarettes lifetime consumption and history of smoking cigarettes every day or most days within the week prior to enrollment * willingness to either "quit for a bit" or "quit for good" in the perioperative period, and; * owning a device with access to sms with an unlimited text plan exclusion criteria: * surgery on the day of poe evaluation * any active psychiatric condition

Keywords: tobacco cigarettes surgery text message sms
cerebellar tms and satiety in prader-willi syndrome

Conditions: Prader-Willi Syndrome

Summary: this study uses a noninvasive technique called transcranial magnetic stimulation (tms) to study hyperphagia and satiety in prader-willi syndrome. tms is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. the magnetic field is produced by a coil that is held next to the scalp. in this study, the investigators will be stimulating the brain to learn more about how tms might improve hyperphagia in prader-willi syndrome.


Eligibility criteria:
inclusion criteria: * diagnosis of prader-willi syndrome exclusion criteria: * contraindications for tms or mri including : * history of neurological disorder * history of head trauma resulting in loss of consciousness * history of seizures or diagnosis of epilepsy or first degree relative family history of epilepsy * metal in brain or skull * implanted devices such as a pacemaker, medication pump, nerve stimulator or ventriculoperitoneal shunt claustrophobic in mri
non-invasive left-sided cervical vagus nerve stimulation for atrioventricular reentrant tachycardia

Conditions: Atrioventricular Reentrant Tachycardia

Summary: the goal of this interventional clinical trials in atrioventricular reentrant tachycardia patients. the main question it aims to answer whether non-invasive vagus nerve stimulation could be effective in restoring rhythm. patients will receive non-invasive vagus nerve electrical stimulation under catheter evoked and cardiac monitoring to observe their heart rhythm changes.

participants will be treated with non-invasive electrical stimulation of the left vagus nerve in the neck. after routine induction of atrioventricular reentrant tachycardia prior to radiofrequency ablation, the electrode patch was placed on the patient's left cervical vagal body surface localization, i.e., between the sternocleidomastoid muscle and the trachea where the left common carotid artery pulsation could be palpated, and resuscitation was performed using non-invasive electrical stimulation.

Eligibility criteria:
inclusion criteria: 1. the relevant diagnostic criteria in the guidelines for the diagnosis and treatment of supraventricular tachycardia (svt) need to be met. 2. all need to be free of psychiatric abnormalities, verbal communication disorders, and have good compliance. 3. the patients and their families gave informed consent and signed the informed consent form. exclusion criteria: 1. does not meet the relevant diagnostic criteria in the guidelines for the diagnosis and treatment of supraventricular tachycardia (svt). 2. mental anomalies, verbal communication disorders, poor adherence 3. those who do not consent to participate in this clinical trial

Keywords: non-invasive vagus nerve stimulation rapid return rhythm