Kornimate/medical-research-clean huggingface dataset:
contemporary modalities in treatment of heart failure

Conditions: Heart Failure

Summary: the contemporary modalities in treatment of heart failure registry (commit-hf) is an observational study on an all-comer systolic heart failure population hospitalized in a highly specialized cardiovascular center. the aim of the study is to assess the clinical characteristics, treatment modalities and prognosis in this population.

the contemporary modalities in treatment of heart failure registry (commit-hf) is a single-center observational study that is underway in the 3rd chair and department of cardiology of silesian center for heart diseases in zabrze, poland. data collection is patient-based (not event-based). the main objective of the commit-hf registry is to clarify the overall clinical characteristics of systolic heart failure patients, their demographics and clinical profile, current management, in-hospital outcomes and long-term follow-up, with regard to the administered treatment. the study population is formed by all-comer patients hospitalized in cardiology wards and intensive cardiac care units with a diagnosis of systolic heart failure. for the purpose of this study heart failure is defined as a set of symptoms resulting from myocardial systolic function impairment, confirmed in resting transthoracic echocardiography with left ventricular ejection fraction (lvef) ≤35%. patients with acute coronary syndromes are excluded from the analysis. complete patient demographics; medical history, complete hospitalization data (diagnostic and therapeutic) and in-hospital results are collected in an electronic form by the attending physician. the patients are under constant follow-up for all cause mortality and major adverse events.

Eligibility criteria:
inclusion criteria: * symptom based diagnosis of heart failure * echocardiographically confirmed impaired left ventricular ejection fraction ≤35%. exclusion criteria: * acute coronary syndrome on admission * ≥ 18 years old

Keywords: heart failure prognosis clinical characteristics
glistenings and pco evaluation for the envista mx60

Conditions: Cataract

Summary: posterior capsule opacification (pco) and glistenings development is among the primary reasons for sub-optimal visual capacity following cataract extraction surgery. primary objective of this study is to evaluate the incidence of pco and glistenings of the popular envista mx-60 intraocular lens (bausch + lomb) in a random sample of cataract patients who underwent phacoemulsification at least 1 year prior to their enrollment at the study


Eligibility criteria:
inclusion criteria: diagnosis of senile cataract with stage 3 nuclear opalescence according to the lens opacities classification system iii (locs-3) grading scale exclusion criteria: endothelial cell count less than 1900, glaucoma, iop-lowering medications, former incisional surgery, former diagnosis of corneal disease, diabetes or autoimmune diseases

Keywords: cataract; intraocular lens; posterior capsule opacification; glistening; envista
nutritional therapy on underweight critically ill patients: an observational study

Conditions: Underweight; Critical Illness

Summary: critically ill patients with body mass index (bmi) inferior to 20 kg/m2 have worse outcomes compared to normal and overweight patients. the impact nutrition therapy in this population is not yet stablished. there is a concern that too low caloric intake might worse their malnutrition; on the other hand, overfeeding is always a risk with serious consequences. the hypothesis of this study is that nutritional support, especially caloric and protein intake, can influence the outcome of underweight critically ill patients.


Eligibility criteria:
inclusion criteria: * ages eligible for study: 18 years and older * gender eligible: both * nutrition therapy: enteral, parenteral feeding, nothing by mouth exclusion criteria: * palliative care * exclusively oral nutrition * pregnancy * life expectancy inferior 24 hours * icu readmission
zero echo time mr for the assessment of maxillary sinus and dental regions

Conditions: Edentulous Alveolar Ridge

Summary: the aim of this study is to evaluate the efficacy of zero echo time magnetic resonance imaging (zte mri) as an ionizing radiation-free diagnostic method to evaluate both hard and soft tissues and maxillary sinus region before dental implants in the posterior maxillary region.

today, cone beam computed tomography (cbct) is routinely used to evaluate the bone structure of the surgical area, to define the anatomical landmarks in the area, to detect variations, if any, and to evaluate the presence of pathologies before dental implant treatment. however, soft tissue evaluations, which are an important factor in treatment planning and the success of the treatment, cannot be performed adequately on cbct images, and in addition, there is a significant increase in the exposure of patients to ionizing radiation. using zero echo time magnetic resonance imaging (zte mri) as a diagnostic tool that does not involve ionizing radiation in dentistry may provide a solution to this situation. the aim of the present project is to evaluate the efficacy of zte mri as an ionizing radiation-free diagnostic method to evaluate both hard and soft tissues and the maxillary sinus region before dental implants in the posterior maxillary region. for this purpose, it is planned to examine cbct and zte mri images of patients planned for dental implant treatment, to perform digital measurements with an intraoral scanner and intraoral direct measurements during surgery and to compare the results of bone and soft tissue measurements obtained.

Eligibility criteria:
inclusion criteria: * missing teeth in the maxillary premolar and molar regions * cone-beam computed tomography images of the tooth-deficient area * do not have any systemic disease that may affect periodontal tissues (diabetes, rheumatoid arthritis, etc.) * over the age of 18 * individuals who approved the informed consent form exclusion criteria: * all maxillary teeth missing * with active periodontitis * under 18 years of age * individuals who did not approve the informed consent form.

Keywords: zte mri cbct intraoral scanner maxillary posterior zone dental implant
postoperative temperature monitoring in brain trauma

Conditions: Brain Injuries, Traumatic; Body Temperature Changes

Summary: this prospective observational study is designed to investigate the relationship between brain temperature, axillary temperature, rectal temperature, and bladder temperature of postoperative patients with brain trauma, and the relationship between brain temperature and prognosis. this study is conducted based on the following important assumptions. first, brain temperature of postoperative patients with brain trauma should be higher than the axillary temperature, rectal temperature and bladder temperature. second, the consistency of brain temperature and bladder temperature is better than the consistency of brain temperature and axillary temperature, as well as that of brain temperature and rectal temperature. third, brain temperature can help clinicians to predict the prognosis of patients with brain trauma. therefore, brain temperature monitoring is significant in postoperative intensive care and treatment of patients with brain trauma.


Eligibility criteria:
inclusion criteria: * clinical or radiological diagnosis is brain trauma; * the patient has surgical indications, and the patient or his/her family are willing to undergo operation including brain temperature monitoring probe implantation; * informed consent is obtained from the patient's family. exclusion criteria: * at the time of admission there are serious systemic diseases, including severe infections, immune system diseases, blood system diseases, infectious diseases, severe liver and kidney dysfunction, malignant tumors, etc; * pregnant or lactating women; * there are other brain tumors or cerebrovascular disease in the brain at the same time; * there is a history of drug or alcohol abuse; * within 3 months before admission, live vaccines were inoculated.
mutual interactions between absence epilepsy seizures and the integration of sensory stimuli

Conditions: Childhood or Juvenile Absence Epilepsy

Summary: epileptic seizures arise from neuronal defects that often alter the capacity of the brain to process sensory information. during absence seizures, a frequent epileptic syndrome in children, the normal conscious and perceptual processes are temporarily interrupted. this is the result of abnormal synchronized neural activities in the thalamo-cortical loops, leading to bilateral spike-and-wave discharges (swds) in the cortical electroencephalograms (eegs). the brain mechanisms underlying the lack of sensory experience during absence seizures are disputed. based on preliminary data, the investigators hypothesize that the alternation of 'spike' and 'wave' patterns during seizure could cause a time-to-time inconstancy in cortical responsiveness, preventing conscious perception. using a real-time closed-loop stimulation system, the investigators will research how the s- and w-patterns specifically alter the sensory-evoked responses in the eeg. during a standard eeg, visual stimulations will be applied between and during absence seizures to test the hypothesis that repeated sensory stimuli, applied with an appropriate timing relative to the seizure-related oscillatory cycle, could negatively interfere with the regenerative network mechanisms involved in the occurrence of swds. the completion of this project should permit to unveil a new neuronal mechanism supporting the lack of conscious experience during absences and pave the way for new clinical non-invasive strategies to interrupt ongoing seizure activity.


Eligibility criteria:
inclusion criteria : * age 2-20 years * childhood or juvenile absence epilepsy defined by international ligue against epilepsy (ilae) * electroencephalogram (eeg) indicated for clinical follow-up non inclusion criteria: * visual deficit * abnormal magnetic resonance imaging (mri) * medical history of photosensitive epileptic seizures
collection of serum samples in studying emotional stress in patients with prostate cancer

Conditions: Hormone-Resistant Prostate Cancer; Recurrent Prostate Carcinoma; Stage I Prostate Cancer; Stage II Prostate Cancer; Stage IIA Prostate Cancer; Stage IIB Prostate Cancer

Summary: this pilot research trial studies the collection of serum samples in studying emotional stress in patients with prostate cancer. studying serum samples from patients with prostate cancer in the laboratory may help doctors determine if levels of epinephrine and cortisol, substances the body makes when stressed, rise or fall with how patients are feeling and/or if those levels are related to clinical information related to prostate cancer.

primary objectives: i. to determine if serum epinephrine or cortisol levels in men with prostate cancer correlate with perceived stress or distress over time in two to five consecutive visits. secondary objectives: i. to determine the change in serum epinephrine levels in men with prostate cancer over time in two to five consecutive visits. ii. to determine the change in serum cortisol levels in men with prostate cancer over time in two to five consecutive visits. iii. to determine the change in levels of stress in men with prostate cancer over time in two to five consecutive visits iv. to determine the change in levels of distress in men with prostate cancer over time in two to five consecutive visits. tertiary objectives: i. to determine if serum epinephrine or cortisol levels in men with prostate cancer correlate with prostate cancer progression two to five visits. outline: patients undergo collection of serum samples for epinephrine and cortisol levels at baseline and 4 clinical visits. patients also receive the self-perceived stress questionnaire and the distress thermometer questionnaire to measure perceived stress.

Eligibility criteria:
inclusion criteria: * a confirmed diagnosis of prostate cancer * eastern cooperative oncology group (ecog) performance status of 0, 1, 2 * individuals able to understand and willing to sign an institutional review board (irb)-approved informed consent document exclusion criteria: * history of current or past medical or psychiatric illness that would make participation difficult or not feasible at the discretion of the principal investigator or co-investigators
bilateral versus monolateral repetitive transcranial stimulation in depression

Conditions: Major Depression

Summary: repetitive transcranial magnetic stimulation (rtms) has been recently fda approved for the treatment of resistant depression. no accordance exists on which are the involved mechanisms of action and on which stimulation parameters, frequency and side are optimal.

to compare these different procedures we study patients with unipolar recurrent resistant major depressive disorder in a double-blind, controlled trial randomized to either sequential bilaterally on the right and left dorsolateral prefrontal cortex (dlpfc) or monolaterally on the right dlpfc. patients will be randomized to receive sequentially low-frequency rtms at 1 hz to the right dlpfc and high-frequency rtms at 10 hz rtms to the left dlpfc, or to receive low-frequency rtms at 1 hz to the right dlpfc. significant antidepressant effect as expressed by a reduction of hamilton depression scale score will be recorded in both the groups of patients.

Eligibility criteria:
inclusion criteria: * diagnostic and statistical manual-iv criteria for depressive major episode hamilton rating scale for depression -28 (ham-d)score ≥ 18 * failure to respond to a minimum of two courses of antidepressant medications for at least 6 weeks exclusion criteria: * any comorbid axis i disorder (except simple and social phobia) * any other significant medical, particularly neurologic, illnesses (seizures, head trauma and brain lesions)

Keywords: depression tms
hpv infection and vaginal microecology in immunosuppressed women

Conditions: HIV Infections; HPV Infection; Cervical Cancer; Anal Cancer

Summary: this study intends to establish a screening cohort for hpv infection and related tumors in areas with high incidence of hiv infection, explore the screening of cervical cancer and anal cancer and the prognosis management model of precancerous lesions in hiv-infected women, and provide a scientific basis for the formulation of malignant tumor screening policies for this population in my country. in addition, this study intends to characterize the cervical, vaginal, and intestinal microecological characteristics of women with different hiv/hpv infection status, so as to explore the impact of cervical, vaginal, and intestinal microecological characteristics on persistent hpv infection or cin/cancer progression.


Eligibility criteria:
inclusion criteria: * hiv positive female, ≥18 years old * hiv infection is sexually transmitted * have an intact cervix * have not received cervical cancer screening in the past 1 year * no previous treatment for cin/cervical cancer * no clinical pregnancy symptoms exclusion criteria: * women who have had a previous cervical resection * unable to complete all screening processes independently * unable or unwilling to accept follow-up * for subjects in vaginal microecology studies, women who used antibiotics within 2 weeks before collecting vaginal secretions, had sexual intercourse within 3 days, or used vaginal medication or vaginal douching within 48 hours need to be further excluded.
sperm dna damage to intracytoplasmic sperm injection outcome

Conditions: Infertility, Male

Summary: in the current era of assisted reproductive techniques where technology can help overcome defects in sperm function, the value of semen analysis has become even more inaccurate. initial reports of intracytoplasmic sperm injection revealed its ability to bypass the natural selection process and enable men with severely impaired semen parameters to achieve both clinical pregnancy and live birth


Eligibility criteria:
inclusion criteria: 1. infertile male patients with abnormal semen parameters. 2. normal female partner aged \<38 years. exclusion criteria: 1. female patients with obvious infertility factor. 2. male patients with azoospermia. 3. male patients with systemic diseases. 4. male patients receiving cytotoxic therapy. 5. male patients with genital pathology as cryptorchidism.
study to confirm the safety and efficacy of tegoprazan in patients with healed erosive reflux disease

Conditions: Erosive Reflux Disease

Summary: this study is designed to evaluate the efficacy and safety of tegoprazan 50mg, compared to lansoprazole 30mg in patients with healed erosive reflux disease confirmed by endoscopy following oral administration once daily(qd) of 2 weeks or 4 weeks.

this is a double blind, radomized, active-controlled, phase 4 study. subjects will be randomly assigned to one of the two treatment groups (tegoprazan 50mg, lansoprazole 30mg)

Eligibility criteria:
inclusion criteria: 1. erosive eshophagitis(la calssfication grades a to d) with in 30 days prior to randomization 2. those who have experienced heartburn symptoms within 7 days prior to visit 1(screening date) exclusion criteria: 1. unalbe to undergo upper gi endoscopy 2. h. pylori positive 3. those who cannot write a clinical trial subject diary 4. presence of esophageal stricture, ulcerated stricture, gastroesophageal varix, long segment barrett's esophagus with \>3cm length(lsbe), eosinophilic oesophagitis, active digestive ulcer or gastric bleeding on an upper gi endoscopy
a pilot study of probiotic saccharomyces boulardii use in chronic heart failure patients. estudo proica

Conditions: Heart Failure

Summary: the purpose of this study is to evaluate the feasibility, safety and effects in inflammatory response of the therapy with a probiotic agent, the yeast saccharomyces boulardii (sb), in chronic heart failure patients.

a cardiointestinal syndrome has been described in heart failure patients, with morphologic and functional intestinal disorders, increased enteropathogenic bacteria concentration, bacterial translocation and inflammatory activation, thus contributing for clinical worsening and progression of the disease. in clinical practice, probiotics has been used in several different conditions, as inflammatory bowel diseases, acute and antibiotic-associated diarrhea, food allergies, and cancer, showing benefits in inflammation and reducing bacterial translocation. however, the use of probiotics in heart failure has never been described.

Eligibility criteria:
inclusion criteria: * class i or ii (nyha)heart failure patients exclusion criteria: * corticosteroid use within 30 days * nsaid use within 30 days * antibiotic use within 30 days * acute infections * inflammatory diseases * autoimmune diseases * cancer * intestinal diseases * chronic renal failure

Keywords: heart failure probiotics saccharomyces boulardii cardio-intestinal syndrome gut inflammation
genetic risk assessment of defibrillator events

Conditions: Sudden Cardiac Death; Arrhythmias; Congestive Heart Failure; Cardiomyopathy

Summary: arrhythmias remain a major health problem, causing at least 250,000 deaths annually in the united states. pharmacological treatments often do more harm than good, and device therapies are limited by high cost and effects on quality of life. ion channel mutations cause rare inherited arrhythmopathies, but account for only a small fraction of patients with life- threatening arrhythmias and sudden death. most arrhythmias occur during myocardial ischemia, following myocardial infarction, and in patients with poor left ventricular (lv) function of any etiology. aside from ejection fraction (ef), few clinically useful indicators to stratify the risk of sudden death have been identified. the role of subtle difference in ion channel expression and/or structure in predisposing patients to arrhythmias and modulating the risk of sudden death is unknown. in this study, we are prospectively testing whether polymorphisms in ion channels and ion channel modifying genes are associated with arrhythmias in a population with internal cardioverter-defibrillators (icds) and poor lv function. we will test the hypothesis that functional polymorphisms in the coding sequences and promoter regions of cardiac genes (e.g. ion channels, beta-adrenergic receptors) predispose individuals to arrhythmias and /or heart failure progression. we hope to identify genetic predictors for the common forms of sudden cardiac death. this would allow the identification of a subpopulation of heart failure patients that would benefit most from icd placement.


Eligibility criteria:
inclusion criteria: * an icd placed during the last 5 years, or a planned icd within 1 month * age 18 or older * left ventricular ejection fraction \< or = 30% * ability to give informed consent exclusion criteria: * patient refuses or is unable to give consent * a life expectancy \<6 months from a non-cardiac life threatening disease * ongoing class iv heart failure symptoms despite treatment * history of cardiac transplant or left ventricular assist device

Keywords: sudden cardiac death arrhythmias congestive heart failure cardiomyopathy single nucleotide polymorphisms genomics
regadenoson and adenosine

Conditions: Coronary Artery Disease

Summary: the aim of the study is to test the accuracy of regadenoson to induce maximal and steady state hyperemia as compared to central venous infusion of adenosine for assessing fractional flow reserve. (adenosine is considered to be the gold standard)and to investigate the time intervals of maximum hyperemia induced by centrally and peripherally administered regadenoson.


Eligibility criteria:
inclusion criteria: * age 18-80 years * scheduled for invasive measurement of ffr for diagnostic and interventional purposes in proximal or mid segments of a coronary artery exclusion criteria: * severe aortic valve stenosis * history of severe copd * syncope or bradycardia (less than 50 beats/min) * known conduction disturbances (2nd-3rd degree heart-block, sick sinus without pacemaker or long qt-syndrome) * severe hypotension (rr \<90 mmhg) * patients in whom no access to the coronary circulation can be obtained by the femoral artery or in whom femoral access was problematic * coronary anatomy not suitable for ffr measurement (extremely tortuous or calcified coronary vessels) * previous coronary bypass surgery * recent st elevation myocardial infarction (\<5 days) * recent non-st elevation myocardial infarction (\ 1000 iu * inability to provide informed consent * pregnancy * use of methylxanthines (in the last 12 hours) * use of dipyridamol (in the last 48 hours)

Keywords: coronary artery disease regadenoson adenosine maximal hyperemia fractional flow reserve ffr