Kornimate/medical-research-clean huggingface dataset:
acute myocardial dysfunction and chest trauma - the strainy trauma study

Conditions: Chest Trauma

Summary: this study aims to investigate whether the identification of acute myocardial dysfunction by 2d-strain transthoracic sonography in the first week following trauma would allow to better diagnose occult and severe patterns of myocardial contusion, in order to identify a subpopulation at higher risk of complications. the measurement of myocardial strain (2d-strain) by transthoracic sonography is a robust tool to assess the myocardial function. the investigators strongly suppose that the 2d-strain would allow to better identify subclinical mc in chest trauma, as well as the severe patterns that are associated with more organs dysfunctions and a worst outcome.

thoracic trauma is the cause of significant morbidity and accounts for 25% of trauma-related deaths. the myocardial contusion (mc) is a distinct injury, which has a prevalence increasing with the severity of the trauma. the diagnostic tool is a major factor to vary the prevalence of mc (i.e. clinical exam, biology, electrocardiogram), with the highest values for autopsy series, until 24% of patients. it does not exist therefore of gold standard for the diagnosis of mc in clinical practice leading to a modest knowledge of this nosological entity. in clinical practice, troponin plasma level determines the diagnostic. otherwise, the measurement of myocardial strain (2d-strain) by transthoracic echocardiography (tte) is a robust tool to assess the myocardial function. this ultrasound analysis allows an objective and topographical quantification of an acute myocardial dysfunction, be it global or segmental. 2d-strain has been thus has been validated for the diagnosis of myocardial dysfunction in medical setting. its use in trauma setting has never been reported.

Eligibility criteria:
inclusion criteria: * severe trauma patients with blunt chest trauma * (ais thorax score ≥ 1) * admitted in our trauma intensive care unit * and included within the 24 first hours following trauma exclusion criteria: * imminent death * recovered cardiocirculatory arrest following trauma * critical patient : ais score ≥5 on 1 lesion, requiring ecls (extracorporeal life support) or reboa (resuscitative endovascular balloon occlusion of the aorta) * refractory hypovolaemia * arrhythmia, atrial fibrillation * congenital heart disease, ischemic cardiomyopathy, moderate or severe pre-existing valvular heart disease, pulmonary arterial hypertension (pah) * valve prosthesis or pacemaker * insufficient quality of ultrasound image to allow correct assessment of 2d-strain * pregnant woman and underage patients

Keywords: severe trauma chest trauma
the effect of a mobile application on enhancing pulmonary rehabilitation after lung cancer surgery

Conditions: Pulmonary Rehabilitation; Telerehabilitation; Lung Cancer

Summary: the goal of this clinical trial is to investigate the effect of a mobile application intervention on postoperative lung rehabilitation. the main purposes of this study are: 1. to understand the effectiveness of the pulmonary rehabilitation mobile application in improving lung function. 2. to assess the feasibility of the pulmonary rehabilitation mobile application in post-surgery rehabilitation care. researchers will compare the intervention group (using the pulmonary rehabilitation mobile application) to the usual care group to determine if the mobile application is effective in lung surgery rehabilitation. participants will join the study immediately after providing informed consent and will continue for up to 7 weeks post-surgery. participants will be randomly allocated to either the intervention group or the control group. both groups will receive regular pulmonary rehabilitation during their hospital stay (1 day before surgery and 2 to 3 days after surgery). researchers will guide participants in the intervention group to use the mobile application for pulmonary rehabilitation exercises throughout the study period. participants in the usual care group will receive health education and an exercise guide before discharge. participants will undergo three study assessments: at baseline (within 1 week after enrollment), post-surgery (week 5), and at follow-up (week 8).


Eligibility criteria:
inclusion criteria: * age over 20 years * primary diagnosis of lung cancer at any stage and type * referral to lung cancer resection by thoracotomy or videothoracoscopy * ability to understand and consent to the trial procedures * conscious and cognition intact exclusion criteria: * included adjuvant treatments (chemotherapy or radiotherapy) * previous history of thoracic surgery * neurological and/or musculoskeletal comorbidities * visual or hearing impairment * acute respiratory illness

Keywords: pulmonary rehabilitation mobile application telerehabilitation lung cancer
connective tissue of pectoralis major muscle: anatomical study

Conditions: Tendon Injury - Upper Limb

Summary: the delto-pectoral tendon (dpt) is a new tendon recently identified. it completes the insertion of the pectoralis major and perfectly explains the different injuries encountered. the objective of this observational study is to visualize this new tendon, the dpt, using ultrasound, to measure it, to characterize its role in the overall architecture of the pectoralis major muscle and to analyze its relationship with its main tendon and the anterior and posterior laminae.


Eligibility criteria:
inclusion criteria: * patient \> 18 years, * consultation for a musculoskeletal pathology of the upper limb exclusion criteria: * history of pathology of the pectoralis major or of the distal tendon of the pectoralis major * pregnant or breastfeeding women * patient under protection of the adults (guardianship, curators or safeguard of justice) * unable to understand * opposition by the patient

Keywords: anterior deltoid tendon anterior lamina pectoralis major posterior lamina pectoralis major pectoralis major tendon ultrasound deep fascia pectoralis major delto pectoral tendon
faster aspart on insulin-pump treated t1dm patients

Conditions: Type 1 Diabetes

Summary: observational retrospective study about effectiveness and safety of insulin faster aspart on continuous subcutaneous insulin infusion treated adult type 1 diabetes mellitus (t1dm) patients in routine clinical practice.

cross-sectional retrospective analysis about effectiveness and safety of insulin faster aspart on continuous subcutaneous insulin infusion treated adult type 1 diabetes mellitus (t1dm) patients in routine clinical practice. all clinical variables are gathered from two emr softwares (mambrino xxi and carelink pro®). data analysis is conducted using spss (chicago, il) statistics software. results are presented as mean ± sd values or percentages. a paired student's t-test or a wilcoxon signed-rank test were used for the analysis of differences. comparisons between proportions were analyzed using a chi-squared test. a p value \< 0.05 was considered statistically significant. the protocol was approved by the reference castilla-la mancha public health institute ethic committee. all participants provided written informed consent.

Eligibility criteria:
inclusion criteria: * ≥18 years of age. * diagnosed of type 1 diabetes mellitus. * be attended in ciudad real general university hospital. * current treated with csii (csii cohort) during ≥6 months. * current treated with insulin faster aspart during ≥3 months. exclusion criteria: * less than 18 years old. * other types of diabetes mellitus.

Keywords: insulin pump faster aspart insulin glycemic variability
enhancing ptsd treatment outcomes by improving patient-provider communication

Conditions: Stress Disorders, Post-Traumatic

Summary: the purpose of this clinical trial is to learn whether existing treatments for posttraumatic stress disorder (ptsd) can be improved. two treatments for ptsd, cognitive processing therapy (cpt) and prolonged exposure (pe) will be studied. cpt and pe are effective treatments that are widely available, but interventions are needed to improve patient outcomes in these treatments. the investigators have developed an adjunctive writing intervention for amplifying response and engagement (aware), which was designed using health communication strategies to enhance cpt and pe by improving communication between patients and therapists about patients' experiences in treatment. this research will investigate whether adding aware to cpt and pe will lead to better treatment outcomes compared to cpt and pe provided as usual without aware. aware includes a brief writing task asking patients about their experiences in treatment, as well as guided therapist responses to improve patient-therapist communication about patients' experiences in treatment. in the first phase of the study (case series phase), cpt or pe with aware will be provided to four adults with ptsd to pilot test adding aware to cpt and pe, seek patient and provider feedback, and refine aware. the first four participants who enroll will be part of the case series and will receive cpt or pe with aware. then, in the second phase of the study, the randomized controlled trial (rct) phase, the investigators will enroll 50 more adults with ptsd who will be randomly assigned (like flipping a coin) to receive cpt/pe as usual or cpt/pe with aware. it is expected that 25 participants will be randomized to cpt/pe with aware and 25 participants will be randomized to receive cpt/pe provided as usual. the goals of the rct phase are to study whether aware is acceptable to patients, whether it is feasible to add aware to cpt and pe, and whether adding aware to cpt and pe improves patient-therapist communication and treatment outcomes compared to cpt/pe as usual.


Eligibility criteria:
inclusion criteria: * diagnosis of ptsd * stable on psychiatric medications for at least 4 weeks exclusion criteria: * current unstable bipolar disorder * current psychosis * current active suicidal or homicidal ideation with intent or plan * current severe substance use that warrants immediate medical attention * current trauma-focused treatment * significant cognitive impairment that would prevent engagement in assessments and therapy (e.g., advanced dementia, severe traumatic brain injury).

Keywords: posttraumatic stress disorder cognitive processing therapy prolonged exposure adjunctive writing for amplifying response and engagement health communication patient-provider communication
metabolic effects of morning 16/8 fasting

Conditions: Overweight and Obesity

Summary: a study to address the effects of early-day fasting on fat tissue mobilization in comparison to a typical isocaloric mediterranean and a low-carbohydrate breakfast.

the study design meets a cross-over pattern with 3 different morning visits of 6 hour duration each. after an informed consent is received from the participant, a crude medical history, physical examination and collection of somatometric data through bio-impendance analysis will take place. an intravenous catheter will be placed in the participants forearm. at zero time point, depending on study visit, participants will either (a) remain fasted (b) start consuming ta pre-prepared zero-carbohydrate 500 kcal test meal (c) start consuming ta pre-prepared 500 kcal test meal with a composition conforming to a standard mediterannean breakfast. participants will be given 10 minutes to consume the meal. blood samples will be drawn and visual analogue scales (vas) for hunger and satiety will be filled in at the following time points (min): -15, 0, 15, 30, 60, 90, 120, 180, 240, 300, 360.

Eligibility criteria:
inclusion criteria: * bmi 18-25 kg/m2 * willfulness to participate exclusion criteria: * overweight or obesity (bmi\>25 kg/m2) * type 1 or 2 diabetes mellitus * uncontrolled thyroid disorders
the effect of patient education on fatigue and quality of life in inflammatory bowel disease

Conditions: Inflammatory Bowel Diseases

Summary: introduction: fatigue is a serious symptom that is seen in a significant portion of ibd patients and negatively affects the patient's quality of life. the aim of this study is to evaluate the effect of patient education on the management of fatigue, which is common in inflammatory bowel diseases. material and methods: this study will be planned with nonrandomized control group, pretest-posttest design. it is planned that the sample group will consist of at least 84 patients, 42 of which are in the intervention group and 42 in the control group. the patients in the intervention group will be evaluated in terms of fatigue and factors that may affect it, and an individualized education program will be offered according to the needs of the patient.for the patients in the control group, only the scales used in data collection will be filled, and no education will be planned. one month after the first interviews, both groups will fill in the scales again.

the aim of this study is to evaluate the effect of patient education on the management of fatigue, which is common in inflammatory bowel diseases.this study will be conducted in ibd outpatient clinic in eskisehir osmangazi university hospital. this study will be planned with a nonrandomized control group, pretest-posttest design. patients who meet the criteria will be assigned to the intervention or control group. it is planned that the sample group will consist of at least 84 patients, 42 of which are in the intervention group and 42 in the control group. the patients in the intervention group will be evaluated in terms of fatigue and factors that may affect it, and an individualized education program will be offered according to the needs of the patient. all patients will be assessed at baseline by use of following tools: patient information form, crohn's disease harvey-bradshaw activity index (hbi), simple colitis clinical activity index (sccai), inflammatory bowel diseases fatigue (ibd-f) scale, inflammatory bowel diseases quality of life assessment questionnaire. patients in the intervention group will be applied one-session individualized patient education by the researcher. the control group will be applied usual care. two groups will be compared at baseline and at the 1st month after the intervention with the same scales

Eligibility criteria:
inclusion criteria: * disease in remission * diagnosis of inflammatory bowel disease with endoscopic procedures * being over 18 years old, * patient's volunteering to participate in the research exclusion criteria: * having a psychiatric illness, * having a diagnosis of chronic fatigue syndrome, * difficulty in communicating (speech, perception, understanding problem), * having an advanced chronic disease

Keywords: fatigue quality of life
the role of isolated nocturnal hypertension pattern in nondialysis ckd

Conditions: Chronic Kidney Disease

Summary: isolated nocturnal hypertension (inh) has been studied among the general population and hypertensive patients. however, little insight is available on the prognostic effect of inh in patients with chronic kidney disease (ckd). this study investigated the prognostic effect of inh in a cohort of chinese patients with nondialysis ckd.

patients with or without isolated nocturnal hypertension will be enrolled in this study, and the patients with isolated nocturnal hypertension will be randomly divided into two groups and treated with bedtime or awakening doses of potassium losartan. any patients who had any antihypertension medication at bedtime would withdrawal the drugs for 2 weeks before abpm. patients with isolated nocturnal hypertension will be randomly divided into two groups and received a bedtime or awakening dose of potassium losartan.

Eligibility criteria:
inclusion criteria: * daytime bp \<135/85mmhg，nighttime bp≥120/70mmhg；； * presence of ckd; * estimated gfr (egfr)\ 30 ml⁄ min ⁄1.73 m2; * signed informed consent from participating patients. exclusion criteria: * pregnancy; * tumor; * infection; * renal replacement; * history of drug or alcohol abuse; * night- or shift-work employment; * treatment with steroids or hormonal therapy; * acute changes in egfr \>30% in the past 3 months; * presence of acquired immunodeficiency syndrome; * cv disorders (unstable angina pectoris, heart failure, life-threatening arrhythmia, atrial fibrillation, kidney failure,and grade iii or iv retinopathy); * intolerance to ambulatory bp monitoring (abpm); * inability to communicate and comply with all of the study requirements.

Keywords: ckd, bedtime dosing, isolated nocturnal hypertension
effects magnesium sulfate and labetalol infusion on peripheral perfusion and pain in nasal surgeries

Conditions: Peripheral Perfusion; Postoperative Pain

Summary: one of main risk of controlled hypotension during nasal surgeries is impaired perfusion. peripheral perfusion of non-vital organs usually impaired earlier than vital organs. so, evaluation of perfusion of non-vital organ is considered to be adequate measure of patient safety during surgery. many hypotensive agents such as dexmedetomidine, b blockers, magnesium sulfate and nitroglycerine had been used but we are in need to investigate its effects on peripheral perfusion. postoperative pain related to nasal surgeries due to surgical trauma itself which induces the release of inflammatory mediators from neuronal and immune cells resulting in peripheral and central sensitization significantly affects recovery of patients. magnesium sulfate and labetalol have analgesic actions besides their hypotensive effects but with different mechanisms.

to compare between the effects of magnesium sulfate and labetalol infusion during induced hypotension on peripheral perfusion and postoperative pain in nasal surgeries objectives: to measure peripheral perfusion index (ppi) as an indicator for peripheral perfusion to calculate the total postoperative rescue analgesic requirements. double -blind randomized comparative clinical study. all patients will be randomly allocated into two equal groups (group m and group l). using computer generated randomization table, each group will be 25 patients.

Eligibility criteria:
inclusion criteria: * written informed consent from the patient. * age: 21-45 years old. * sex: both sex (males or females). * physical status: asa 1\& ii. * bmi = (20-30 kg/m2). * type of operations: elective nasal surgeries such as septoplasty, endoscopic sinus surgery and polypectomy. * duration of surgery ≤ two hours. exclusion criteria: * altered mental state * patients on beta blocker or with known history of allergy to study drugs. * advanced hepatic, renal, cardiovascular or respiratory diseases. * diabetic patients. * patients receiving anticoagulants or on pain killers.
prevalence and clinical characteristics of patients with jackhammer esophagus and symptoms of gastroesophageal reflux disease

Conditions: Esophageal Motility Disorders

Summary: gastroesophageal reflux disease (gerd) is involved in the development of esophageal motility disorders like jackhammer esophagus (je), a novel hypercontractile condition that was associated with progression to achalasia and limited outcomes following surgical anti-reflux therapy. this trial was designed to assess the prevalence and characteristics of je in patients with typical symptoms of gerd and responsiveness to ppi therapy.

jackhammer esophagus is a novel hypercontractile esophageal disorder. the investigators assess the prevalence and clinical characteristics of patients diagnosed with this disorder out of a collective of patients that are referred with symptoms of gastroesphageal reflux disease and respond to ppi. this is an observational trial.

Eligibility criteria:
inclusion criteria: * patients with symptoms of gastroesophageal reflux disease and diagnosis of jackhammer esophagus exclusion criteria: * patients not willing to participate data or undergo screening for gastroesophageal reflux disease

Keywords: esophagus motility
quality of life and fertility of patient with deep surgical endometriosis: a prospective cohort

Conditions: Deep Infiltrating Endometriosis

Summary: endometriosis is a common gynaecologic disease affecting 5 to 15% women of reproductive age and up to 40% of infertile women. it is characterized by the presence of active endometrial tissue outside the uterine cavity, potentially causing invalidating chronic pelvic pain and infertility. it is therefore crucial to limit the progression and/or recurrence of the disease, and to improve the quality of life of affected women. deep infiltrating endometriosis (die), an advanced form of the disease, is defined by the invasion of an anatomical structure and organ close to the uterus (i.e. uterosacral ligament, rectovaginal space, recto-sigmoidal colon or bladder), or by a peritoneal invasion greater than 5mm. the management of die is unfortunately not yet based on high-level evidence data; it mainly depends on the localization of the disease, the extend of the invasion and the severity of the symptoms. in the absence of clear guidelines based on empirical data, the choice between surgical or medical treatment remains difficult and controversial. to improve optimal die management, the investigators aim to create a prospective database reporting on die surgically treated in a teaching hospital in lyon/france (centre hospitalier universitaire lyon sud) data on known risks factors, symptoms (pain), quality of life, infertility history and disease management will be obtained using self-questionnaires, clinic, paraclinic, surgical and histological records as follow. 1. each patient will be asked to fill in electronics protected on-line forms: the first one before surgery, followed by three follow-up forms at 1, 2 and 5 years after surgery. 2. the surgeon will be asked to fill in two electronic protected on-line forms: the first one at the time of surgery and the second one during a post-operative consultation (one month after surgery). the questionnaires used in this study are similar to those used for the endometriosis database "cirendo" (explain briefly what it is), which will ultimately allow us to pool the data from the 2 databases. this french prospective study will advance the scientific knowledge on die surgical treatment and, by helping evaluate the impact of the surgery on the quality of life and fertility of affected women, will guide future recommendations for an optimal management of this invalidating disease.


Eligibility criteria:
inclusion criteria: * surgically management for deep endometriosis exclusion criteria: * no surgical management necessary * isolated adenomyosis
status asthmaticus on the picu; intravenous salbutamol

Conditions: Childhood Asthma With Status Asthmaticus

Summary: although iv salbutamol is frequently used in children in a wide range, pharmacodynamic data are scarce. to date, there is an insufficient evidence base to guide initial and subsequent dosing recommendation for its iv use in children. especially the need for a loading dose needs to be addressed. therefore, pharmacodynamic and kinetic data are needed to guide initial dosing strategies of iv salbutamol in children. to assess the efficacy of a loading dose of intravenous salbutamol in children admitted to a picu for severe acute wheeze or severe acute asthma. efficacy is measured by the reduction in asthma score (qureshi) at 1 hour after administration of the loading dose, compared to placebo.


Eligibility criteria:
inclusion criteria: * between 2-18 years of age at moment of inclusion * admitted to picu for severe acute asthma or severe acute (viral) wheeze * requiring administration of iv salbutamol exclusion criteria: * patient is outside of specified age range * patient has already received a -loading dose- of iv salbutamol in the general hospital * lower airway infection with consolidation on a chest x ray -patient has down's syndrome * patient has a congenital/acquired heart defect that interferes with normal asthma treatment * patient has a primary/secondary immunodeficiency * patient has a pre-existing chronic pulmonary condition, known to mimic asthma: cystic fibrosis, bronchopulmonary dysplasia, bronchiolitis obliterans