Kornimate/medical-research-clean huggingface dataset:
study of the effectiveness of mental contrasting and implementation intention in the management of apathy in schizophrenia

Conditions: Schizophrenia; Apathy

Summary: schizophrenia is a mental pathology that concerns 1% of the french population, characterized by heterogeneity of symptoms. one of them, apathy is defined as a multidimensional psychopathological state manifested by a decrease in motivation. this deficit is most common in schizophrenia and impacts the functional outcome of patients. to date, no treatment has shown a significant effect on this symptom. in other pathologies with a motivational deficit, the technique of mental contrasting and implementation intention (cm-ii) showed interesting effects in improving motivation, reducing the effort related to the action. the investigators aim to propose the cm-ii technique to individuals with schizophrenia to improve apathy. the investigators expected that the cm-ii technique will allow an improvement of apathy which will have beneficial effects on other psychological factors (e.g., depressive symptoms). in addition, the implementation of the cm-ii will provide help to global management.


Eligibility criteria:
inclusion criteria: * age ≥ 18 and \< 60 years old * diagnosis of schizophrenia according to dsm 5 criteria. * score greater than or equal to -18 on the lille apathy rating scale * ability to understand and speak french. * obligation to belong to or be a beneficiary of a social security scheme. * signature of the consent. if the participant has a representative, signature by the representative. exclusion criteria: * history of head injuries or neurological pathologies. * current treatment with sismotherapy or repetitive transcranial magnetic stimulation (rtms). * treatment targeted at and/or influencing negative symptoms (cbt, cognitive remediation), or therapeutic trial. * participant under safeguard of justice. * pregnant or breastfeeding woman.

Keywords: implementation intention mental contrasting apathy schizophrenia motivation
3d printed breast models in the surgical management of breast cancer

Conditions: Breast Cancer

Summary: to learn if providing a 3-d printed model of the breast can help breast cancer patients make decisions related to their care. during this study, some study participants will receive the 3-d printed model and some study participants will receive traditional breast imaging scans to learn if the 3-d printed model

primary objective: •the objective of this prospective study is to determine the impact of 3d printed breast models, compared to 2d imaging, on breast cancer patients' decisional conflict related to treatment decision-making. secondary objective: * to observe if patients will change their initial desired surgical option (mastectomy versus lumpectomy) after viewing the 3d printed models * to evaluate the quality of the communication between surgical providers and patients with and without the 3d printed models * to assess the surgical outcome including the margin status * to evaluate patient satisfaction and well-being post-surgery between the 3d printed model group and the control group as well as mastectomy versus lumpectomy subgroups * to assess surgical providers' response to the acceptability and utility of the model

Eligibility criteria:
inclusion criteria: * age 18 or older female * patient must have histologically confirmed breast malignancy * patient is a candidate for surgical management * patient has a surgeon at mdacc (main campus and/or houston area locations) * patient has a breast mri for extent of disease assessment at mdacc (main campus and/or houston area locations). * patient is able to speak, read or write english * patient is willing to be randomized to the control or 3d printed breast model groups and is willing to sign the consent form. exclusion criteria: * pregnant and breastfeeding patients * patients who had history of mastectomy, have recurrent malignancies on the mastectomy side * patients for whom it is not feasible to create a 3d printed breast model from breast mri
grade analysis of veins by mri and ct in post-thrombotic syndrome

Conditions: Lower Limb Venous Thrombosis

Summary: the aim is to improve the diagnosis of chronic lower limb venous thrombosis before a lower limb venous recanalization procedure. additionally, if the mri scores are comparable to those of the ct, mri would reduce radiation exposure and limit the need for foot vein punctures that accompany ct use.

endovascular management of post-thrombotic syndrome (pts) has created new opportunities for patients and interventional radiologists. pts is the most chronic complication of deep vein thrombosis (dvt), occurring in 20% to 40% of patients despite optimal anticoagulant therapy within the first 1 to 2 years after a lower limb dvt. pts is characterized by various symptoms lasting more than 6 months after a dvt, including mild pain or swelling, venous claudication, heaviness/fatigue, chronic pain or cramps, venous ulcers, edema, skin discoloration, and venous ectasia. severe pts negatively impacts quality of life. several clinical tools or scales, such as the villalta scale and civiq-20, are used to diagnose and define pts. endovascular treatment of symptomatic chronic iliofemoral vein occlusions has shown good technical and clinical efficacy, with significant clinical benefits and improvements in the villalta and civiq scores. proper planning of the recanalization procedure is essential, using ct and mri imaging to analyze the venous anatomy in the pelvis, abdomen, and lower limbs. the ct is the reference examination for chronic lower limb thrombosis, performed using the baldt technique to opacify the deep venous network and detect endoluminal adhesions. however, there are risks such as failure to puncture the veins on the back of the foot, pain during puncture, and flow artifacts. mri is less commonly used due to its availability and long examination times, but its results are promising. the literature on chronic lower limb thrombosis is limited, with no consensus on lesion descriptions, highlighting the need for a descriptive lesion score

Eligibility criteria:
inclusion criteria: * men and women aged more than 18 years old, * patient's oral consent, * affiliated or beneficiary of health insurance exclusion criteria: * inability of the patient to understand the nature or risks or significance and implications of the clinical investigation, * patient under legal protection

Keywords: post-thrombotic syndrome ct veins mri severity score multicenter study
effect of nutritional indices on the prognosis of hcc patients

Conditions: Hepatocellular Carcinoma

Summary: primary liver cancer has recently ranked among the leading causes of cancer death, with hepatocellular carcinoma (hcc) accounting for 75%-85% of these cases. in recent years, immune checkpoint inhibitors (icis) combined with tyrosine kinase inhibitors (tkis) have achieved good results in the treatment of advanced hcc patients. so far, there is a lack of studies exploring the relationship between nutritional index and the prognosis of hcc patients treated with icis combined with tkis, and there are few studies on the prognostic value of nutritional index in hcc patients treated with transarterial chemoembolization (tace). this retrospective study aims to analyze the prognostic value of prognostic nutritional index(pni)，body mass index (bmi), psoas muscle index（pmi）and geriatric nutritional risk index (gnri) in hcc patients who received icis combined with tkis or tace, and to provide reference for the selection of nutritional intervention programs for hcc patients.

patients who confirmed hcc in the second affiliated hospital of chongqing medical university were enrolled in the retrospective study. the subjects were divided into two cohorts, both of which met the inclusion and exclusion criteria.the data needed to be collected included age, gender, height and weight at initial treatment and regular follow-up. blood routine, liver function, kidney function, coagulation function, electrolytes, pivka-ii, afp, hbv-dna, ct, mri information, china liver cancer staging (cnlc), complications, treatment plan, etc. follow-up time after initiation of treatment and time of death or significant disease progression. the survival was estimated by the kaplan-meier method and curves were compared by the log-rank test.logistic regression was used to univariate and multivariate analyze the effect of variables on the outcome. variables with p\<0.05 on a univariate analysis were subjected to a multivariate analysis.

Eligibility criteria:
inclusion criteria: cohort 1:hcc patients received icis combined with tkis regularly and periodically. cohort 2:hcc patients who underwent tace as initial treatment. exclusion criteria: 1. patients with systemic malignant tumors other than hcc. 2. patients with severe hypertension, diabetes, coronary heart disease, systemic infection and other serious diseases. 3. patients with immunodeficiency or autoimmune diseases. 4. patients with severe malnutrition. 5. not adhering to regular and periodic treatment. 6. patients without regular follow-up or with missing data to be collected.

Keywords: prognostic nutritional index psoas muscle index geriatric nutritional risk index prognosis
support for covid19 patients at home

Conditions: COVID19 Patients

Summary: the rapid spread and increase of acute respiratory infection cases caused by the novel sars-cov-2 coronavirus represent a major challenge for healthcare systems around the world. the shortage of facilities and medical personnel is a major problem in the face of a serious epidemic. the lombardy region, and in particular the territories of milan, bergamo and brescia, was the most affected due to the rapid increase in cases and limited medical resources during the initial phase of the epidemic. the collaboration between hospital and territory with integrated communication systems and the monitoring of patients with appropriate technological tools that include telemedicine, are fundamental to ensure the continuity of care and the sustainability of the health system, also significantly reducing the risk of contagion for health professionals.

the mirato project wants to test the remote health surveillance services and a telemonitoring program for patients discharged after a period of hospitalization for covid19 caused by the new coronavirus sars-cov-2 and their comorbidities if present. patients discharged from hospitals still present in many cases breathing difficulties, bed rest symptoms and other disabilities related to the acute event. in addition, some patients are seeing rekindling of symptoms such as fever, dry cough, difficulty respiratory and blood desaturation into oxygen. these problems underline the need for procedures that allow us to safely discharge patients to be able to better follow their convalescence but also to be able to intervene quickly in the event of symptoms returning. the purpose of the home health surveillance intervention will be: * monitor the evolution of the state of health with standardized tools based on scientific evidence * provide counselling support to help recovery * have certain and early identification of signs and symptoms related to a possible resumption of the covid19 pathology and or to comorbidities * compare outcome results with case-control design three months after hospital discharge

Eligibility criteria:
inclusion criteria: * hospitalisation for covid19 * patients discharged at home exclusion criteria: * patient refusal * patients discharged at a nursing home
multi-formula optimization of second eye refinement according to direction of the prediction error of the first eye

Conditions: Cataract

Summary: prediction errors for the first (pe1) and second eyes (pe2) were obtained in the intra-ocular lens power calculation for 4 formulae (hofferq, srk ii, srk/t and holladay 1). the optimal correction factor for each formula was determined as the one resulting in the lowest mean absolute error. a similar analysis was performed in the negative and positive pe1 subgroups.

retrospective case series study. a retrospective chart review was conducted, which included demographics (age and gender) and several parameters for both the first and second eyes: surgery date, axial length, keratometric corneal power in 2 meridians, predicted intra-ocular lens (iol) power recommended for plano target in each formulae (hofferq, srk ii, srk/t and holladay 1), implanted iol power, predicted post-operative refraction for the implanted iol for the 4 formulae, observed post-operative refraction in spherical equivalent and post-operative best corrected visual acuity. the prediction error was calculated for the first eye (pe1) as the difference between the observed post-operative refraction in spherical equivalent and the predicted post-operative refraction by the iol master for the implanted iol. this was obtained for the 4 formulae. the prediction error for the second eye (pe2) was obtained in a similar fashion. the optimal partial adjustment for second eye refinement was obtained subtracting a portion of the pe1 from the pe2 (pe2-xpe1, where 0≤x≤1) for the 4 formulae. the optimal correction factor was determined for all formulae by using an array of different proportions of pe1 that were applied to the second eye. the values ranged from 10% to 100%, with increments of 10% each.

Eligibility criteria:
inclusion criteria: * patients having performed bilateral cataract surgery between 1st october 2012 and 24th april 2014 in a single ophthalmological center (centro hospitalar baixo vouga, portugal) exclusion criteria: * inadequate follow-up * incomplete medical records * previous or combined ocular surgery * manual extracapsular cataract extraction and not phacoemulsification * corneal sutures * implantation of any other iol type different from abbott tecnis® 1-piece iol (abbott laboratories inc., illinois, usa), zcb00 * iol implanted in the sulcus * intra or postoperative complication * post-operative best corrected visual acuity worse than 5/10 * corneal astigmatism\>3.00 d
inflammation and protein restriction

Conditions: Protein Restriction; Diet; Inflammation

Summary: there is strong scientific data that supports that short-term protein restrictive diets reduce surgical stress responses. the investigators are hoping to use the information collected from the blood serum and muscle tissue of healthy subjects to help understand the baseline and early changes in muscle energetic and cell-mediated inflammation. the study team hopes to use the data collected in this pilot study to compare with patients undergoing open abdominal aortic aneurysm (aaa) repair in a future study

modulation of a patient's diet, specifically via short-term dietary protein restriction, can impact changes in cell energetics and dampen the normal subclinical inflammatory state. these changes can provide benchmarks for future research focused on using nutritional interventions aimed at improving the probability of a successful outcome following open aortic aneurysm surgery. the investigators will conduct a short term dietary restriction protocol to characterize these changes in a normal control cohort to be compared to patients which undergo surgery, to identify the optimal time points for sampling in the surgical population. these changes will be characterized by looking at inflammatory cells in the blood, proteins excreted in the urine, changes in microbiome signature identified by stool sample and oral swab, as well as changes in muscle energetics in small muscle biopsies.

Eligibility criteria:
inclusion criteria: * healthy volunteers between 18 and 70 years of age exclusion criteria: * age less than 18 years. * the presence of any significant medical condition that might significantly confound the collection of biological data in the study including cancer, diabetes, inflammatory bowel disease (ibd), advanced renal disease, nut allergy * unwilling to follow protocol * participation in another interventional clinical trial. * prisoners, pregnancy, or direct employees of the investigative team
prophylactic tricuspid annuloplasty during mitral valve surgery

Conditions: Tricuspid Valve Insufficiency

Summary: single center randomized study to test whether a prophylactic tricuspid annuloplasty at the time of mitral valve procedure can improve clinical and echocardiographical outcomes.

the optimal management of functional tricuspid regurgitation (ftr) in the setting of mitral valve operations remains controversial. the current practice is both center- and surgeon-specific with guidelines based on non-randomized data. a prospective randomized trial was performed to evaluate the worth of less-than-severe ftr repair during mitral valve procedures. a single center randomized study was designed to allocate patients with less-than-severe ftr undergoing mitral valve surgery to be prophylactically treated + tricuspid valve annuloplasty (tvp- or tvp+). these patients were analysed using longitudinal cardiopulmonary exercise capacity, echocardiographic follow-up, and cardiac magnetic resonance (cmr). the primary outcome was more than mild tricuspid regurgitation (tr) recurrence with vena contracta \>3mm. secondary outcomes were maximal oxygen uptake (vo2 max) and right ventricular (rv) dimension and function.

Eligibility criteria:
inclusion criteria: * patients undergoing mitral valve surgery with less than sever tricuspid insufficiency exclusion criteria: * presence of pacemaker lead through the tricuspid valve * acute endocarditis * minimally invasive approach * functional mitral valve insufficiency
vildagliptin 100 mg once daily vs. placebo as add-on therapy in patients with type 2 diabetes inadequately controlled with metformin

Conditions: Diabetes Mellitus, Type 2

Summary: this study will investigate efficacy and safety of vildagliptin in patients with low baseline levels starting at an hba1c level of 6.5% to support convenient early intervention with combination therapies. in parallel, morning and evening dosing will be evaluated in this patient population for the first time.


Eligibility criteria:
inclusion criteria: * male, non-fertile female or female of childbearing potential using a medically approved birth control method * patients who have received metformin for at least three months prior to visit 1 and have been on a stable dose for a minimum of 8 weeks prior to visit 1 * agreement to maintain the same dose of metformin throughout the study * age in the range of 18-85 years inclusive. * hba1c in the range of 6.5 - 8.0% (inclusive) at visit 1 * agreement to maintain prior diet and exercise habits during the full course of the study * ability to comply with all study requirements and signed informed consent to participate in the study. exclusion criteria: * pregnant or lactating female a history of: * type 1 diabetes, diabetes that is a result of pancreatic injury, or secondary forms of diabetes, e.g. cushing's syndrome and acromegaly. * acute metabolic diabetic complications such as ketoacidosis or hyperosmolar state (coma) within the past 6 months. any of the following significant laboratory abnormalities: * alt, ast greater than 2 times the upper limit of the normal range at visit 1. * direct bilirubin greater than the upper limit of the normal range at visit 1. * serum creatinine levels equal to or greater than 1.5 mg/dl (132 umol/l) males, equal to or greater than 1.4 mg/dl (123 umol/l) females, or a history of abnormal creatinine clearance at visit 1. * clinically significant tsh values outside of normal range at visit 1. * clinically significant laboratory abnormalities, confirmed by repeat measurement, other than hyperglycemia, hyperinsulinemia, and glycosuria at visit 1 treatment with any oral anti-diabetic other than metformin within 3 months prior to visit 1 other protocol-defined inclusion/exclusion criteria may apply

Keywords: type 2 diabetes vildagliptin metformin combination
the effect of erector spinae plane block on fentanyl consumption during abdominal hysterectomy

Conditions: Post Operative Pain

Summary: this study aims to evaluate the effects of erector spinae plane block on intraoperative fentanyl consumption in patients undergoing abdominal hysterectomy under general anesthesia. to our knowledge, no study in the literature demonstrates this effect.

this study will be performed in fayoum university hospital after approval of the institutional ethics committee and written informed consent. this study will be conducted as a prospective, randomized, double-blind, parallel-group clinical trial. inclusion criteria: * american society of anesthesiologists (asa) physical status i, ii patients who will be scheduled for elective abdominal hysterectomy. * age range above 18. exclusion criteria: * patient refusal. * significant renal, hepatic and cardiovascular diseases. * history of allergy to one of the study drugs. * any contraindication to regional anesthesia such as local infection or bleeding disorders. * chronic opioid use, history of chronic pain and cognitive disorders. the patients will be randomized into two groups: esp block group who will receive preoperative us-guided bilateral esp block with 20 ml of bupivacaine 0.25% on each side and control group who will undergo the same procedure but with an injection of 20 ml of saline on a 1:1 ratio using a computer-generated random table. the patient's assigned group information will be elicited from a sealed opaque envelope by the anesthesiologist who will perform the esp block and will not be involved in further data collection or patient care. the patients and both the surgical and anesthesia teams, who are responsible for patient care and data collection are blinded from the group assignments.

Eligibility criteria:
inclusion criteria: - inclusion criteria: * american society of anesthesiologists (asa) physical status i, ii patients who will be scheduled for elective abdominal hysterectomy. * age range 18-70 years exclusion criteria: * patient refusal. * significant renal, hepatic, and cardiovascular diseases. * history of allergy to one of the study drugs. * any contraindication to regional anesthesia such as local infection or bleeding disorders. * chronic opioid use, history of chronic pain and cognitive disorders.
the immediate effect of an osteopathic manual treatment on blood pressure in adults with hypertension - a pilot study.

Conditions: High Blood Pressure

Summary: the aim of this study was to determine if 4 manual osteopathic treatment techniques; spinal manipulation, stretch intrathoracic fascia, sternum recoil and cranial base release has an immediate effect on blood pressure (bp) in hypertensive adults.

30 hypertensive adults (age=50.76±8.66 years, height= 1.75±0.082 m, weight=89.5±19.08 kg), were randomly assigned into one of two equally sized groups; a non- intervention and an intervention group in which patients received 4 manual techniques. outcome measures included systolic- and diastolic bp pre-treatment and post-treatment 1-,5-, and 10-minutes. two-way mixed anova was used for statistical analysis.

Eligibility criteria:
inclusion criteria: * adults 18-60 years old. * primary hypertension. * hypertension not more than grade 2, defined as: systolic bp from 135-174 mmhg and diastolic bp from 85-104 mmhg. exclusion criteria: * hypertension grade 3, defined as: systolic bp from \>175 mmhg and diastolic bp \>105 mmhg, due to high risk of developing stroke, apoplexy and myocardial infarct. * positive hepato-jugular-reflux test, as a safety-test, to test pathological conditions of the heart. * history of liver, kidney or known heart diseases, diagnosed by family physician as these conditions can contribute to secondary hypertension. * presence of contraindications for manual treatment, such as (but not limited to); infections, neurological symptoms, inflammation, haemophilia, ankylosis, prosthesis, pregnancy, cancer, osteoporosis, trauma and the use of blood-thinning medicines or corticosteroids.

Keywords: hypertension manual techniques blood pressure osteopathy treatment