Kornimate/medical-research-clean huggingface dataset:
a study on a blood-based dual-target test for crc detection

Conditions: Colorectal Cancer; Colorectal Adenoma

Summary: to evaluate the effectiveness and accuracy of the ctdna dual-target test kit in a large case-control cohort for the detection of colorectal cancer and advanced adenomas.

usually, colorectal cancers (crcs) diagnosed in their early stages are curable, especially precancerous lesions (adenomas, polyps) that can be removed during a colonoscopy.however, due to low patient compliance and limited resources, colonoscopy is not feasible for screening the average-risk population. gfobt/fit are limited by their low sensitivity and high false-positive rate. compared to colonoscopy and stool dna tests, blood-based methylation tests showed greater patient compliance and convenience. hypermethylated ntmt1 and map3k14-as1 were found in multiple cohorts of crc samples in our previous study. in this study, we aimed to evaluate the effectiveness and accuracy of the ctdna dual-target(ntmt1 and map3k14-as1) test kit in 5 tertiary hospitals around china for the detection of colorectal cancer and advanced adenomas. fecal immunochemical test (fit) will also privided to participants in the study. sanger sequencing would be performed to evalute the accuracy of the dual-target methylation detection test kit.

Eligibility criteria:
inclusion criteria: 1. inclusion criteria for crc group（≥30%） 1)patients with colorectal cancer 2)follow-up sample subjects: subjects who underwent resection of colorectal cancer lesions. 2. inclusion criteria for control group（≤70%） health volunteer, or subject with other diseases or physiological conditions other than colorectal cancer, including but not limited to gastritis, gastric cancer, esophagitis, rheumatoid arthritis, prostate cancer, microbes (inflammation patients), gastrointestinal bleeding, drugs (typical digestive tract medication) population), neuroendocrine cancer, squamous cell carcinoma (squamous squamous cell carcinoma, esophageal squamous cell carcinoma); exclusion criteria: 1. patients who had undergone radical resection of bowel cancer (except for postoperative follow-up) and those who had received anti-tumor therapy such as radiotherapy/chemotherapy； 2. colorectal cancer or colorectal adenoma with other malignancies； 3. postoperative follow-up patients of colorectal cance with distant metastasis; 4. the sample size collected did not meet the detection requirements; 5. other patients who are considered unsuitable for this study (such as pregnancy, high blood pressure, heart disease, etc., who are not suitable for colonoscopy due to physical condition).

Keywords: ctdna methylation diagnostic test
effects of slow-stroke back massage on crf

Conditions: Chemotherapy-releated Fatigue

Summary: chemotherapy-related fatigue (crf) is common in patients with breast cancer and it can be seen between 27% and 96% depending on the stage of cancer and treatment method. at the same time, crf is reported as the most important symptom that reduces the functional capacity of patients with breast cancer and impairs their quality of life. for this reason, there is a need for an intervention that could decrease or prevent of crf in breast cancer patients. in the literature, it is stated in the evidence-based guidelines that massage, which is one of the non-pharmacological methods, can be effective in crf management.

this an assessor-blinded,parallel group randomized controlled trial aimed that investigating the effect of slow-stroke back massage on crf in breast cancer patients.this trial was conducted in the chemotherapy outpatient clinic of university hospital located in turkey. all patients were women who received adriamycin-cyclophosphamide (ac)/ cyclophosphamide-adriamycin-5 fluoro-uracil (caf) regimens every 21 days.

Eligibility criteria:
inclusion criteria: * 18 years and older women, * stages ii or iii breast cancer patients who had received at least 1 cycle of chemotherapy and were scheduled to receive 3 more cycles, * receiving one of the adriamycin-cyclophosphamide/cyclophosphamide-adriamycin-5-fluorouracil (ac/caf) chemotherapy protocols, exclusion criteria: * with metastasis * having open wounds and edema on the upper limbs and back * using any complementary and alternative (cam) treatment method to prevent fatigue during administration

Keywords: chemotherapy-releated fatigue slow-stroke back massage nursing
short course radiation therapy in palliative treatment of esophageal cancer

Conditions: Esophageal Cancer; Radiotherapy; Palliative Care

Summary: aim of the study is to assess efficacy of a short course radiation treatment in patients with symptomatic esophageal malignant lesions

standard treatment for esophageal lesions (3000 cgy in 10 daily fractions of 300 cgy each) is compared with experimental treatment (2000 cgy in 4 fractions of 500 cgy twice a day) to demonstrate non-inferiority of this scheme

Eligibility criteria:
inclusion criteria: * symptomatic esophageal malignant lesions (primary solid tumors or metastases from solid tumor); * age\>18 years; * ecog performance status 0-3 * no changes in supportive care in the week before radiotherapy exclusion criteria: * pregnancy * previous irradiation of the same region

Keywords: short course radiotherapy symptomatic esophageal lesions
urinary calculi after bladder augmentation in children

Conditions: Calculi, Urinary; Neurogenic Bladder Disorder; Spina Bifida; Child, Only

Summary: the goal of this observational study is to analyse the occurence of urinary calculi after bladder augmentation in children: * location of the calculi (kidney or bladder) * type of bladder augmentation with higher rate of urinary calculi and why * find risk factors of urinary calculi in bladder augmentation (age, sex, other bladder procedures..)

study the data of patients younger than 18 years old, who underwent a bladder augmentation, complicated by urinary calculi.

Eligibility criteria:
inclusion criteria: * patients younger than 18 years old, with urinary calculi, after bladder augmentation exclusion criteria: * patients older than 18 years old, with urinary calculi, after bladder augmentation

Keywords: urinary calculus bladder augmentation child retrospective study
nasogastric tube vs. orogastric feeding tube in preterm infants: which is best?

Conditions: Infant, Premature

Summary: the purpose of this study is to find out which method (nasogastric vs. orogastric) of feeding tube for premature infants results in earlier only oral feeding.

preterm infants, even as young as 23 weeks gestational age, can be fed enterally at the first week of life. coordination of sucking and swallowing, and coordination of both and breathing is necessary for efficient and safe oral feeding, and is not well established before the 35th week gestational age. that is why tube feeding is essential for preterm infants younger than that age. there is no consensus regarding the best way for the feeding tube, i.e. oral vs. nasal, and whether placing the tube should be continuous or intermittently. nasogastric tube has been associated with vagal responses. both tubes may cause gastric perforation. development and function of oral feeding has been described. it is known that non-nutritive sucking and early introduction of oral feeding accelerate the transition from tube feeding to oral feeding. it is suggested that the preterm infant may experience a maturational lag in vagal function related to ingestive needs, which may contribute to continued feeding difficulties and may be a measurable marker of subtle neurodevelopmental problems. both oral and nasal feeding tube may interfere with establishment of efficient oral feeding. the purpose of this study is to see whether there is a difference between oral and nasal tube feeding, regarding the institution of oral feeding.

Eligibility criteria:
inclusion criteria: * all preterm infants, born during one year, who required tube feeding, and later discharged from neonatal intensive care unit. exclusion criteria: * infants who died during hospitalization * infants with severe neurologic deficit (e.g. after sarnat ii-iii asphyxia, or as a part of a syndrome * infants with gastrostomy * infants who were transferred to another hospital for any reason (e.g. heart surgery)

Keywords: infant, premature tube feeding
motor imagery for reach-to-grasp rehabilitation after tetraplegia

Conditions: Tetraplegia C5-C6; Tetraplegia C6-C7

Summary: single center, pilot study, to evaluate the influence of motor imagery (mi) on functional rehabilitation and cerebral plasticity through the qualitative and quantitative mental practice approach. for this, the investigators will use magnetoencephalography (meg) but also physiological and behavioral indicators developed by the laboratoire de la performance motrice, mentale et du matériel (p3m) of université claude bernard lyon 1 and its partners.


Eligibility criteria:
inclusion criteria: * 18-55 years old, * quadriplegia elicited by spinal cord injury (sci) at the c5, c5-c6, c6, or c6-c7 level, * complete infra-lesional motor deficit according to the asia impairment scale with finger and forearm flexor muscles paralysis, * post-traumatic period \>6 months (since a motor recovery plateau is usually reached at 6-month post-sci exclusion criteria: * non-stabilized hypertension or pathological autonomic nervous system dysfunction (e.g., orthostatic hypotension), * cerebral damage and/or cognitive deficit, * elbow or shoulder joint amplitude restriction, upper limb para-osteoarthropathy, * participation to another study * presence of metallic objects within the body incompatible with meg or functional magnetic resonance imaging (fmri) recordings.

Keywords: cervical spinal cord injury motor imagery magnetoencephalography
yoga for young adults affected by cancer

Conditions: Young Adult Cancer; Young Adult Oncology

Summary: yoga may enhance physical and psychological outcomes among young adults affected by cancer. yet, yoga has rarely been studied in this population. we developed and piloted a yoga program, which is now ready for implementation and evaluation. this single-group, mixed-methods project will explore effectiveness and implementation of the yoga program.


Eligibility criteria:
inclusion criteria: 1. adult aged 18 years or older; 2. diagnosed with cancer between the ages of 18-39 years; 3. at any stage of their cancer experience (i.e., on- or off-treatment); 4. able to safely engage in yoga, as assessed by completing the get active questionnaire and obtaining medical clearance (if indicated). 5. willing and able to complete informed consent, questionnaires, physical assessments, and an interview in english. exclusion criteria: 1. previous enrolment in the study, to avoid contamination and/or ceiling effects.
efficacy and safety of cytokine adsorption and plasma exchange in patients with hbv-aclf and sepsis

Conditions: Acute-On-Chronic Liver Failure; Sepsis

Summary: this study aims to evaluate the efficacy and safety of the double plasma cytokine adsorption system with sequential low-dose plasma exchange (dpcas+lpe) in patients with hepatitis b-related acute-on-chronic liver failure (hbv-aclf) complicated by sepsis. the focus is on assessing the impact of the cytokine adsorption column(ca280,jafron biomedical co., ltd., zhuhai, china) on survival rates, inflammation markers, and organ function to determine its potential value in clinical practice. the primary research questions are: (1) does dpcas+lpe artificial liver therapy improve the 4-week mortality rate in hbv-aclf patients with sepsis? (2) does it improve the 12-week mortality rate in these patients? additionally, the study examines the effects of this therapy on apache ii scores, sofa scores, vasoactive-inotropic score, meld scores, and cossh-aclf ii scores, as well as the cytokine adsorption efficiency of the ca280. patients were randomly assigned to either the dpcas+lpe group or the plasma exchange(pe) group. all patients received artificial liver therapy every other day, for a total of two sessions. follow-up assessments were conducted before and after each therapy session, as well as at 1, 2, 3, 4, and 12 weeks.


Eligibility criteria:
inclusion criteria: 1. age between 18 and 65 years. 2. total bilirubin (tbil) \> 12 mg/dl, 3\>inr ≥ 1.5. 3. meets the diagnostic criteria for sepsis 3.0: confirmed or suspected infection with an increase in sofa score by ≥ 2 points. 4. high inflammatory state: il-6 \> 100 pg/ml. 5. persistent hbsag or hbv dna positivity for more than 6 months. 6. onset of sepsis within the past 72 hours. exclusion criteria: 1. presence of other causes of chronic liver disease, such as infection with other hepatotropic viruses, alcoholic liver disease, autoimmune liver disease, or genetic metabolic liver disease. 2. patients with liver malignancies or other concurrent cancers. 3. pregnancy or lactation. 4. patients with hiv infection or other immunodeficiency diseases. 5. patients with autoimmune diseases, recent cardiovascular events leading to unstable infarction, or a history of organ transplantation. 6. end-stage organ failure: end-stage chronic obstructive pulmonary disease, end-stage pulmonary heart disease, brain death, or persistent vegetative state, grade iv hepatic encephalopathy. end-stage renal disease or acute renal failure requiring crrt. inability to maintain a mean arterial pressure above 65 mmhg despite adequate fluid resuscitation, vasopressors, and steroid therapy. 7. platelet count \< 50×10⁹/l, severe coagulopathy, or active bleeding. 8. allergic reactions to extracorporeal circulation, hemoperfusion substances, or history of severe allergies. 9. inability to comply with study protocols or refusal to sign the informed consent form. 10. inability to attend regular follow-up visits according to the study schedule. 11. any other conditions that, in the investigator's judgment, make the patient unsuitable for inclusion in the study.
trial of etoricoxib (arcoxia) taken prophylactically to prevent ramadan headache

Conditions: Headache; Fasting; Fasting Headache; Ramadan Headache

Summary: the investigators intend to study whether the use of the pain medication etoricoxib (arcoxia) taken just before the ramadan fast will prevent or lessen headache that some people get while fasting. the investigators hypothesize that etoricoxib will reduce the number of people getting headache, more than placebo. the investigators will do this by giving participants in the study either real medication or placebo (sugar pill) and comparing the results. the investigators will study this over two weeks. the first week one group will get the medicine and the other the placebo. the second the groups will switch. neither the subjects nor the investigators will know who is in which group.


Eligibility criteria:
inclusion criteria: * age 18 -65. * patients will be enrolled if they declared that they intended to complete the dawn to dusk ramadan fast, and had demonstrated their commitment by doing so for the previous three years (unless medically prevented.) * patient states that he/she typically suffered from headache during fasting in the past. exclusion criteria: * patients with a history of severe cardiovascular disease, diabetes, asthma, copd, hypertension, or a history of bleeding, particularly in the gastrointestinal tract * patients who have experienced bronchospasm, acute rhinitis, nasal polyps, angioneurotic oedema, urticaria, or allergic-type reactions after taking acetylsalicylic acid or nsaids including cox-2 (cyclooxygenase-2) inhibitors * pregnant or lactating patients. sexually active women of childbearing age will be included only if using birth control * severe hepatic dysfunction * estimated renal creatinine clearance \<30 ml/min * history of peptic ulcer, erosive gastritis, esophagitis or inflammatory bowel disease * congestive heart failure * patients with hypertension whose blood pressure is persistently elevated above 140/90mmhg and has not been adequately controlled established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease * cancer or any other malignant disease * history of medication overuse. overuse of analgesics or antimigraine drugs according to the ihs criteria (chapter 8)

Keywords: headache fasting fasting headache ramadan ramadan headache yom kippur yom kippur headache
bilateral closed loop deep brain stimulation for freezing of gait using neural and kinematic feedback

Conditions: Parkinson Disease

Summary: deep brain stimulation of the subthalamic nucleus (stn) has become a standard of care, fda-approved treatment for parkinson's disease, with stimulation delivered at a constant amplitude and voltage, operating in an open-loop fashion that does not respond to a patient's current state. although gait deficits and freezing of gait may initially respond to continuous open-loop deep brain stimulation (oldbs) and medication, the symptoms often recur over time. the episodic and predictable nature of fog makes it well suited for adaptive dbs (adbs) and a device that overcomes the limitations of traditional high frequency oldbs and is capable of adapting therapy either in the frequency or intensity domain transiently to treat fog while also treating other pd signs such as tremor and bradykinesia. the purpose of this study is to determine the feasibility of an adaptive dbs system, that responds to patient-specific neural and kinematic variables with customized dbs parameters.


Eligibility criteria:
inclusion criteria: * clinically-established pd * meets criteria for stn dbs eligibility as part of patient's standard medical care or already implanted in the stn with percept(tm) pc * the presence of complications of medication such as wearing off signs, fluctuating responses and/or dyskinesias, and/or medication refractory tremor, and/or impairment in the quality of life on or off medication due to these factors. * ability and willingness to return for study visits, at the initial programming and after three, six and twelve months of dbs. * age \> 18 * freezing of gait questionnaire (fog-q) score ≥ 1 and/or gait sub-score (item 3.10) of mds- updrs iii ≥ 1 * greater than or equal to 1.2 microvp between 8-35 hz on either the lstn or rstn (percept (tm) pc cohort only) exclusion criteria: * dementia * untreated psychiatric disease * hoehn and yahr stage 5 on or off medication (non-ambulatory) * age \> 80 * major surgical morbidities such as severe hypertension, coagulopathy and certain metabolic conditions that might increase the risk of hemorrhage or other surgical complications * presence of a cardiac pacemaker/defibrillator * inability to understand/sign consent * requires rtms, ect, mri (summit(r) rc+s cohort only), or diathermy * are pregnant or lactating * has a cranial metallic implant * history of seizures or epilepsy
does skyla insertion timing impact bleeding?

Conditions: Vaginal Bleeding

Summary: women presenting for contraception will be offered the ius skyla and study participation. daily bleeding will be collected for a total of 90 days and correlated with insertion timing and baseline endometrial thickness.


Eligibility criteria:
inclusion criteria: * women aged 18-45 * parous or nulliparous * desire skyla for contraception * regular menstrual cycles (21-35 days) * working mobile phone and willing to accept text messages and report daily bleeding data for 90 days exclusion criteria: * vaginal or cesarean delivery in the past 12 weeks * abortion in the past 6 weeks * uterine anomaly distorting the uterus * acute pelvic inflammatory disease * uterine bleeding of unknown etiology * acute liver disease or tumor * history of progestin-sensitive cancer * abnormal pap smear awaiting diagnostic or therapeutic intervention

Keywords: intrauterine device bleeding
effect of therapeutic touch on sleep quality and anxiety in individuals with chronic obstructive pulmonary disease

Conditions: COPD; Anxiety; Sleep

Summary: purpose: the purpose is to determine the effect of therapeutic touch on the sleep quality and anxiety of individuals with chronic obstructive pulmonary disease. material and methods: this study was conducted between march 2018 and march 2019 as a randomized controlled experimental study conducted with pre-test post-test model. in addition to the routine nursing care, therapeutic touch (tt) and study scales were applied to the experimental group for a total of three sessions, once a day and 10 minutes each, for three consecutive days and only study scales were applied to the control group. the data was collected using personal information form, richard-campbell sleep questionnaire and state anxiety inventory.


Eligibility criteria:
inclusion criteria: * over the age of 18 * literate * oriented, open to communication and cooperation * those who are hospitalized in the clinic for at least four days * patients who volunteered to participate in the study were included. exclusion criteria: * have any diagnosed psychiatric disorder * using antidepressants, antihistamines, benzodiazepines, hypnotic and narcotic drugs * persons using any other complementary and alternative treatment method during the therapeutic touch application were not included in the study.

Keywords: chronic obstructive pulmonary disease therapeutic touch sleep quality anxiety
air pollution and cardiovascular disease

Conditions: Metabolic Disorder

Summary: to determine the effects of ambient airpollution exposures on cardiovascular responses among healthy adults without cardiovascular disease.


Eligibility criteria:
inclusion criteria: * without cv disease or risk factors (e.g., hypertension, diabetes, or treated hyperlipidemia). subjects are non-smokers in non-smoking household. exclusion criteria: * screening visit bp\>140/90 mm hg, fasting glucose \>126 mg/dl, or positive urine pregnancy test (females). subjects cannot be taking any medications or over-the-counter drugs that affect cv function.
acupuncture combined with pulmonary rehabilitation: are there additional benefits?

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the hypothesis of this study was that acupuncture in conjunction with standard care of pulmonary rehabilitation improves outcome measures compared to pulmonary rehabilitation alone.

pulmonary rehabilitation is recognized as a pivotal component in international guidelines for the management of chronic obstructive pulmonary disease (copd). in patients with copd, clinical research using acupuncture has reported a significant reduction in the use of medications, decrease breathlessness and increased functional capacity. to our knowledge, this is the first time that these two treatments were combined to compare functional, physiological, biological and emotional/qol outcomes in this cohort of patients.

Eligibility criteria:
inclusion criteria: * a diagnosis of copd based on the gold staging of the disease * medical research council score of 3 or above * ability of mobilize independently * motivated to exercise independently exclusion criteria: * no evidence of copd on spirometry * acute exacerbation within 4-6 weeks * evidence of ischemic heat disease/acute changes on ecg * uncontrolled hypertension * insulin dependent diabetic * inability to exercise independently or musculoskeletal/neurological conditions which would prevent completion of the course * fear of needles * lung cancer * previous attendance at pulmonary rehabilitation

Keywords: acupuncture, pulmonary rehabilitation, inflammation, copd