Kornimate/medical-research-clean huggingface dataset:
influence of adipocytokines in osteoarthritis

Conditions: Osteoarthritis, Knee; Endocrine System Diseases; Cardiovascular Risk Factors

Summary: adipocytokines play an important role in joint inflammation in patients with knee osteoarthritis as measured by ultrasound and high sensitivity protein-c reactive. adipocytokines could be the link between osteoarthritis and cardiovascular risk factors more prevalent in these patients.


Eligibility criteria:
inclusion criteria: * patients over 50 years old with symptomatic knee osteoarthritis. exclusion criteria: * patients with secondary osteoarthritis of the knee * any other rheumatologic condition.

Keywords: adipocytokines osteoarthritis cardiovascular risk
tolerance and acceptability evaluation aymes actagain

Conditions: Malnutrition

Summary: to evaluate tolerance and acceptability of 'aymes actagain' in patients requiring supplementary oral nutritional support compared with currently available alternatives.

to evaluate tolerance and acceptability of 'aymes actagain' in patients requiring supplementary oral nutritional support compared with currently available alternatives, measuring outcomes of gi effects, compliance, product preference, convenience etc. to obtain data to support an acbs submissions for 'aymes actagain' (to allow for prescription in the community at nhs expense).

Eligibility criteria:
inclusion criteria: * male and female patients. * ≥ 18 years of age. * patients of the intended target group (e.g. must score ≥ 1, with or at risk of disease related malnutrition) with an anticipated period of nutritional support ≥ 4 weeks. * patient is able and willing to provide written informed consent. exclusion criteria: * patients with medical or dietary contraindication to any feed ingredients. * patients requiring sole enteral tube feeding or parenteral nutrition. * patients with chronic renal disease requiring dialysis. * patients with liver failure. * patients for whom the investigator has concerns regarding the ability or willingness of the patient and or carer to comply with protocol requirements. * patients assessed by a speech and language therapist who require thickened fluids. * participation in any other studies that may interfere with this study.
long term follow up and outcome of left ventricular remodeling in st segment myocardial infarction patients after ppci

Conditions: Left Ventricle Remodeling

Summary: * to detect long-term effects of left ventricular remodeling in stemi patients undergoing ppci. * and to evaluate outcome.

acute myocardial infarction (ami) with its accompanying adverse sequelae remains one of the most common causes of morbidity and mortality in the world . reperfusion therapy is by far the most important therapy for the treatment of acute mi. reperfusion of the ischemic myocardium reduces the infarct size and improves left ventricular function, both of which contribute to an improved clinical outcome in patients with acute mi . using primary pci has reduced the mortality of patients with acute mi . however, the increased survival rate resulted in the increased incidence of cardio vascular events mainly due to lv remodeling and congestive heart failure . post-infarct ventricular remodeling develops in about 30% of patients with a history of myocardial infarction. ventricular remodeling is a predictor of heart failure and for this reason it assumes a negative prognostic value . left ventricular remodeling after st-segment elevation myocardial infarction (stemi) treated with primary percutaneous coronary intervention is a major determinant for the short-term and long-term clinical outcomes . adverse left ventricular remodeling refers to alterations in ventricular architecture involving both the infarcted and non-infarcted zones leading to progressive increase in systolic and diastolic left ventricular volumes. left ventricular remodeling following a st-segment elevated myocardial infarction (stemi) is an adaptive response to maintain the cardiac output despite myocardial tissue loss. limited studies have evaluated long term ventricular function after stemi. left ventricular remodeling, both positive and negative, is an ongoing process and continues at least up to 2 years after stemi, involving the infarct zone and remote zones. long-term left ventricular ejection fraction (lvef) deterioration is characterized by an increase in end-systolic volume and less wall thickening in the remote zones. patients with long-term lvef improvement exhibit an increase in left ventricular wall thickening both in the transmural infarct and remote zones. for elucidation of long term effects of left ventricular remodeling, the current study is conducted.

Eligibility criteria:
inclusion criteria: * all patients were treated successfully by primary pci more than 2 years ago within 12 hours of onset of chest pain or up to 24 hour of onset of chest pain if there was ongoing ischemia at assiut university cardiac hospital cath. lab. exclusion criteria: * patients with clinical manifestations of acute heart failure or cardiogenic shock at presentation. * significant mitral regurgitation or valve disease. * patients with permanent pacemaker insertion.
sleep quality after nasosinusal surgery in aerd patients

Conditions: Aspirin-exacerbated Respiratory Disease; Sleep

Summary: aspirin exacerbated respiratory disease presents as a triad composed by asthma, eosinophilic rinosinusitis and intolerance to aspirin and nsaids. in subjects with chronic rhinosinusitis sleep alterations have been found, with important improvement after surgery, but those alterations and improvements have not been studied in patients diagnosed with aerd who, due to their comorbidities, may present more severe pre surgical symptoms and a more important post-surgical improvement. the investigators aim to study patients with aerd sleep, quality of life and symptoms before surgery, and one, three and six months post-surgery.


Eligibility criteria:
inclusion criteria: * aerd patients. * cumbersome nasal polyposis with poor treatment response exclusion criteria: * previously diagnosed sleep disorder. * psychiatric disorder

Keywords: endoscopic sinus surgery
optimizing nutrition and milk (opti-num) project

Conditions: Very Low Birth Weight Baby; Early Nutrition and the Preterm Infant; Nutritional Requirements; Human Milk Fortification; Human Milk Microbiome; Human Milk Feeding; Human Milk Nutrition; Growth &Amp; Development

Summary: early nutrition critically influences growth, neurodevelopment and morbidity among infants born of very low birth weight (vlbw), but current one-size-fits-all feeding regimes do not optimally support these vulnerable infants. there is increasing interest in "precision nutrition" approaches, but it is unclear which human milk (hm) components require personalized adjustment of doses. previous efforts have focused on macronutrients, but hm also contains essential micronutrients as well as non-nutrient bioactive components that shape the gut microbiome. further, it is unclear if or how parental factors (e.g. body mass index, diet) and infant factors (e.g. genetics, gut microbiota, sex, acuity) influence relationships between early nutrition and growth, neurodevelopment and morbidity. understanding these complex relationships is paramount to developing effective personalized hm feeding strategies for vlbw infants. this is the overarching goal of the proposed optimizing nutrition and milk (opti-num) project. the opti-num project brings together two established research platforms with complementary expertise and resources: 1) the maximom program\* with its clinically embedded translational neonatal feeding trial network in toronto (dr. deborah o'connor, dr. sharon unger) and 2) the international milk composition (imic) consortium, a world-renowned multidisciplinary network of hm researchers and data scientists collaborating to understand how the myriad of hm components contribute "as a whole" to infant growth and development, using systems biology and machine learning approaches. members of the imic corsortium that will work with on this study are located at the university of manitoba (dr. meghan azad), university of california (dr. lars bode) and stanford (dr. nima aghaeepour).

observational study mode: the opti-num project is a retrospective secondary data/sample use study. time perspective: secondary use data and biospecimens accruing from the 2 completed studies domino and optimom (nct02137473) and 1 ongoing rct maximom (nct05308134) are included in this project. sampling method: this project is a secondary use of data/samples, from a cohort consisting of participants of the maximom platform rcts.

Eligibility criteria:
inclusion criteria: • secondary data and biospecimens from participants of the maximom platform rcts exclusion criteria: • data and biospecimens from infants who are not enrolled in the three trials are eligible for this project.

Keywords: very low birth weight infants early nutrition and the preterm infant human milk feeding
the effect of imagery exercises on attention and performance in olympic archers

Conditions: Performance Improvement in Beginner Archers

Summary: the goal of this clinical trial is to for beginners in archery in to examine the effects of imagination and breathing exercises given in addition to 8-week archery training on archery target score, postural sway, attention, hand grip, visualization and respiratory function parameters.. the main questions it aims to answer are: * do imagination and breathing exercises have an effect on archery target shooting score? * do breathing exercises positively affect shooting performance by reducing postural sway? * do archers' imagination skills positively affect their attention and performance? * do hand grip strength and reaction time positively affect shooting performance? participants will routine exercises used in archery training will be applied to all participants. researchers will compare control group, imagination group and meditation group to see if control group (cg); only routine exercise program will be applied. to the imagination group (ig); in addition to routine exercises, a 15-minute visualization session will be applied. respiratory group (sg); breathing exercises will be applied in addition to routine exercises.


Eligibility criteria:
inclusion criteria: * completing the study consent form, * successful in the the closed kinetic chain upper extremity stability test (ckcuest), * successful in the upper quarter y balance test (ybt), * those who do archery sports were included in the study. exclusion criteria: * having musculoskeletal system problems, * having a neurological disease, * having vestibular disease, * having pulmonary disease, * hearing loss, * those who have undergone orthopedic surgery will not be included in the study.

Keywords: breathing exercises imagination cognition exercise sports young adult
rct on the efficacy of dexamethasone versus methyl prednisolone in covid-19 infected patients with high oxygen flow

Conditions: COVID-19 Pandemic

Summary: this study aims to evaluate the therapeutic activity and side effects of 16 mg/day dexamethasone in comparison to equivalent dose of mp (1mg/kg/day)for the management of covid-19 infected patients.moreover, and according to the importance of the il-6/stat-3 in triggering the inflammatory cascade and as the mirnas are considered as prognostic markers, hence, the study aims also to study the impact of the used regimens on these biomarkers


Eligibility criteria:
inclusion criteria: 1. adult (≥18 years of age) at time of enrolment 2. present covid-19 (infection confirmed by rt-pcr or antigen testing) 3. postive pressure ventilation (non-invasive or invasive) or need supplemental oxygen with non-rebreather mask 4. admission to icu in the last 24 hours exclusion criteria: * 1- underlying disease requiring chronic corticosteroids 2- any dose of dexamethasone during the present hospital stay for covid-19 for ≥5 days before enrollment 3- systemic corticosteroids during present hospital stay for conditions other than covid-19 (e.g. septic shock) 4-any contraindication for corticosteroid administration 5-cardiac arrest before icu admission 6-pregnancy or breast feeding 7- immunocompromised patients as cancer (active) patients, patients on chemotherapy or radiotherapy, hiv, and transplant patients

Keywords: steroids
randomized study of maintenance therapy with mgn1703 in patients with sclc

Conditions: Small Cell Lung Cancer

Summary: evaluation of efficacy and safety of mgn1703 administered twice weekly subcutaneously (sc) as maintenance treatment in patients with extensive disease small cell lung cancer (sclc) who achieved at least a partial response (pr) following platinum-based first-line therapy.


Eligibility criteria:
1. male and female patients with extensive disease sclc ≥ 18 years of age receiving first line treatment; 2. histology of sclc or mixed histology of sclc if sclc histology is at least 80%; 3. completion of 4 cycles of first-line therapy with a platinum-based regimen and no other prior chemotherapy; 4. documented evidence of tumor response as assessed by investigators after the first 2 cycles of platinum-based chemotherapy followed by a confirmed pr or cr at the end of fourth cycle by ct or mri scan; 5. brain metastases are allowed only after cranial irradiation, if not requiring continuous treatment with steroids or anticonvulsants; 6. ecog performance status 0 or 1; 7. adequate organ function with total bilirubin, lactate dehydrogenase \[ldh\], alkaline phosphatase \[ap\], gamma glutamyltransferase \[ggt\], albumin, creatinine, urea, electrolytes, and coagulation parameters ≤ 1.5 × upper limit of normal (uln), and with aspartate aminotransferase \[ast\] and alt ≤ 2.5 × uln in the absence of liver metastases or ≤ 5.0 × uln in the presence of liver metastases; 8. adequate hematological parameters: absolute neutrophil count ≥ 1.5 × 109/l; platelet count ≥ 100 × 109/l; leukocyte count ≥ 3.0 × 109/l; lymphocytes ≥ 1.0 × 109/l; hemoglobin ≥ 9.0 g/dl or 5.59 mmol/l; 9. patients with reproductive potential agree to use effective contraceptive measures throughout the study; 10. negative pregnancy test in women of childbearing potential; 11. signed informed consent form (icf).

Keywords: extensive disease after first line therapy immuno therapy
individualized prevention strategy for high risk patients in cardiovascular disease: prospective cohort study (cardiovascular and metabolic disease etiology research center - high risk cohort) cmerc-hi

Conditions: High Risk Cardiovascular Disease Patients

Summary: set the prospective cohort (cmerc-hi) to study the known and novel etiologies and related factors for predicting clinical outcomes in korean patients with high risk cardiovascular disease.


Eligibility criteria:
inclusion criteria: * high risk hypertension patients a. egfr \> 60 with one of target organ damages b. egfr \<= 60 * diabetes mellitus with microalbumin ration (ac ratio \>= 30mg/g) * anuric esrd patients on dialysis * the relatives of acute myocardial infarction patients under 55 years old (men)/ 65 years old (women) * atherosclerotic cardiovascular disease (abdominal aorta diameter ≥3 cm or ankle-brachial index \ 30% stenosis in at least one major coronary artery) * rheumatoid arthritis patients aged \> 40 years on mtx and steroid therapy * atrial fibrillation patients with chads-vasc score ≥ 1 * kidney transplant recipient at \> 3 months after transplantation exclusion criteria: * acute myocardial infarction, acute coronary syndrome patients, symptomatic coronary artery disease or history of these diseases * symptomatic peripheral artery disease, heart failure and history of these diseases * desired life time under 6 months due to non-cardiovascular disease (e.g. cancer, sepsis) * women with pregnancy or on nursing * history of contrast allergy and related side effects * within the first three months after transplantation * acute renal allograft rejection

Keywords: cardiovascular disease metabolic disease high risk prospective cohort
sierrasil joint formula 14 as an ergogenic aid to performance in athletes

Conditions: Muscle Power; Muscle Fatigue

Summary: the purpose of this study is to examine whether supplementation with sierrasil can improve anaerobic power and reduce muscle fatigue in a group of well-trained athletes. a secondary purpose is to examine the effect of sierrasil on the severity of delayed onset muscle soreness.

this is a double blind, crossover, pilot study that will examine the effect of sierrasil supplementation on the determinants of human performance. anaerobic capacity, muscle fatigue, the severity of delayed onset muscle soreness (doms) and markers of inflammation will be measured before and after 3 weeks of supplementation with sierrasil or placebo. there will be a 3 week washout period prior to the crossover to ensure sierrasil supplementation has no residual effect.

Eligibility criteria:
inclusion criteria: * no contraindications to strenuous exercise exclusion criteria: * muscle or joint injury * taking any form of anti-inflammatory or pain medication * females due to the variability that might be introduced due to the phases of the menstrual cycle

Keywords: muscle power muscle fatigue sierrasil
safety and efficacy of mucinex and ir guaifenesin the treatment of symptoms of acute upper respiratory tract infections

Conditions: Acute Upper Respiratory Tract Infection

Summary: the study is designed to meet regulatory requirement outside the us. the dosing regimen and assessments timepoints were dictated by immediate release (ir) guaifenesin (gge) and do not match approved mucinex labeling in the u.s. the purpose of this study is to determine whether mucinex is effective and non-inferior as compared to placebo and immediate release guaifenesin in the treatment of symptoms of acute upper respiratory infections. this design was required based on eu regulatory guidance.


Eligibility criteria:
inclusion criteria: 1. has developed cold symptoms within 3 days prior to dosing on day 1. exclusion criteria: 1. chronic illnesses. 2. febrile illness \> 101 f within 7 days prior to day 1, 3. pregnant. 4. known current malignancy.
validity and reliability of the turkish version of atrial fibrillation impact questionnaire (afimpact)

Conditions: Atrial Fibrillation

Summary: validity and reliability of the turkish version of 'atrial fibrillation impact questionnaire (afimpact)' will be evaluated in the study.

atrial fibrillation (af) is the most common sustained arrhythmia with a reported incidence of 2.1% in turkish population aged 60 and above. although a minority of patients have minimal or no symptoms, palpitations, dyspnea and fatigue are frequently reported by af patients. it is well documented that af patients, including those with no symptoms, have poorer quality of life (qol) compared to healthy population. worrying about their condition, side effects of treatments and worsening health are the other factors that have an impact on qol, beside symptoms. management of qol is a key therapeutic goal in af treatment and guidelines recommend that qol in these patients should be measured regularly. there is a concern in the literature that generic qol measures may not be sufficiently sensitive or specific to measure af related qol, thus using disease specific qol measures are recommended for af patients. an af-specific quality of life measure is lacking in turkish language, thus our aim in this study is to validate the turkish version of 'atrial fibrillation impact questionnaire (afimpact)' in turkish af patients.

Eligibility criteria:
inclusion criteria: * diagnosis of paroxysmal, persistant or permanent atrial fibrillation * to be able to read and understand turkish exclusion criteria: * diagnosis of heart failure or any chronic lung diseases * recent coronary bypass surgery * previous heart valve surgery * rheumatic valvular heart disease * recent acute myocardial infarction * having a pacemaker

Keywords: atrial fibrillation quality of life
the impact of a novel coaching program on medical errors and well-being of physicians

Conditions: Burnout; Adverse Event; Medical Education

Summary: this is a randomized controlled trial with a mixed method design to determine the impact of coaching on self-perceived medical errors, burnout, and resilience. the study team developed a novel coaching curriculum based in principles of positive psychology and self-reflection with the hypothesis that the coaching intervention will lead to decreased medical errors, decreased burnout, and increased resilience in trainee and faculty participants. resident and fellow trainees as well as faculty members were recruited across departments and randomized to coaching or control. faculty in the coaching arm were trained in coaching techniques and paired with a trainee coachee. survey results as well as focus groups will be used to analyze the impact of the coaching program as compared to standard mentorship (control).


Eligibility criteria:
inclusion criteria: * residents and fellows in a training program at beth israel deaconess medical center (bidmc) * faculty members at bidmc

Keywords: coaching burnout wellness medical errors
a study of vpriv in participants with gaucher disease previously treated with other enzyme replacement therapies or substrate reduction therapies

Conditions: Gaucher Disease

Summary: the main aim of this study is to describe the safety profile of velaglucerase alfa (vpriv) in participants with gaucher disease type 1. participants will be transitioning from other enzyme replacement therapies or substrate reduction therapies to vpriv. some participants may have already transitioned to treatment with vpriv before this study started. in this study, data on vpriv will be collected from the medical records of participants who already transitioned to vpriv before this study started. other participants will join this study when they transition to vpriv. all participants will be followed to allow for 12 months of observation from time of transition to vpriv. the study sponsor will not be involved in how participants are treated but will provide instructions on how the clinics will record what happens during the study.


Eligibility criteria:
inclusion criteria: * participant with gd1 currently being treated with an ert/srt other than vpriv for at least 6 months before baseline enrolment; or participant previously treated with another ert/ srt for at least 6 months prior to transitioning to vpriv.. * participant or legally authorized representative has provided written informed consent. exclusion criteria: * in the opinion of the investigator, participant is at high risk of non-compliance. * in the opinion of the investigator, participant is unsuitable in any other way to participate in this study. * participant is pregnant.