Kornimate/medical-research-clean huggingface dataset:
prevention of renal failure in people followed for type 2 diabetes in general practice

Conditions: Renal Insufficiency and Diabetes Mellitus

Summary: this work will make it possible to identify the nephron loss of type 2 diabetic patients in the western region and to better define in general practice the impact of the elements put in place to reduce this loss and to raise awareness of the importance of these measures through training in comparison with a control group.


Eligibility criteria:
inclusion criteria: * patient consulting his or her investigating general practitioner * 50 years old or more * type 2 diabetic for more than 5 years, with a gfr lower than 90 ml/mn and higher than 45 ml/mn (stage 2 and 3a of renal failure) and a nephron loss calculated on the average of the two previous years, higher than 3 ml/mn/year * a microalbuminuria \> 30 mg/gr of creatinuria. * having declared the investigator as the treating physician exclusion criteria: * patient under 50 years of age patients who do not agree to the use of their data (refusal of consent) or are unable to give consent (dementia, other) patients with other types of diabetes patients with renal failure other than diabetic or hypertensive glomerulopathy patients unable to give consent patients who do not understand the french language patients with less than 3 months of planned follow-up patients with a barrier to follow-up patients undergoing dialysis, transplantation

Keywords: diabetes mellitus, type 2 kidney diseases primary care prevention early diagnosis
effect of chronic statin and viagra therapy in persons with endothelial cell dysfunction

Conditions: Endothelial Dysfunction

Summary: to determine if 6 weeks of daily treatment with atorvastatin 40 mg alters the immediate effect of sildenafil citrate (viagra, pfizer inc, new york, ny) on endothelial function (activity of the artery) as measured by noninvasive peripheral arterial tonography in men and women. also, to determine if 6 weeks of daily treatment with atorvastatin 40 mg affects erectile function in men


Eligibility criteria:
inclusion criteria: * patients undergoing coronary angiography * no previous statin use * age \> 18 years old * no pde5-1 use in the past 6 months exclusion criteria: * patients with an acute coronary syndrome * patients with cardiogenic shock * patients \> 30% coronary stenosis * patients with unexplained muscle pain * patients with acute liver disease * patients receiving immunosuppressant therapy, azoles, macrolide antibiotics, niacin, l-arginine * patients with serum creatinine \> 2.0 * patients with total cholesterol \> 200 mmol/l * patients on current statin therapy or clinically indicated to be on statin therapy

Keywords: testing for endothelial dysfunction and coronary angiography
imaging pulmonary aspergillosis using gallium-68-deferoxamine

Conditions: Pulmonary Aspergillosis; Chronic Pulmonary Aspergillosis; Allergic Bronchopulmonary Aspergillosis

Summary: this is a single center open-label feasibility trial involving a single study visit for participants. the purpose of the study is to demonstrate the feasibility of \[68ga\]ga-dfo-b pet/ct (gallium-68-deferoxamine) for the visualization of pulmonary aspergillus infection. the incidence of fungal infections is on the rise and are associated with significant mortality. diagnosis pulmonary aspergillosis can be can be challenging, often requiring invasive tests such as bronchoscopy and lung tissue biopsies. molecular imaging, specifically using radiolabeled siderophores like \[68ga\]ga-dfo-b, offers a non-invasive and location-specific approach to visualize and evaluate infections. siderophores, critical for pathogenic microbes like aspergillus fumigatus, play a role in iron acquisition. preclinical studies with radiolabeled deferoxamine (dfo-b) demonstrated distinct accumulation at infection sites. additionally, \[68ga\]ga-dfo-b pet/ct may differentiate between aspergillus infection and cancer, making it a promising non-invasive diagnostic tool for pulmonary aspergillosis.


Eligibility criteria:
inclusion criteria: 1. the patient is at least 18 years old on the day of inclusion. 2. the patient has suspected chronic pulmonary aspergillosis or abpa. 3. there is no significant interference with standard care and follow-up. exclusion criteria: 1. the patient is pregnant or planning on becoming pregnant. 2. the patient has severe kidney dysfunction with egfr \< 30 ml/min/kg and/or receives dialysis. 3. the patient has (chronic) iron overload. 4. the patient has been receiving antifungal treatment for more than 48 hours prior to the study day. 5. the patient is not able to lie still in the scanner.
preoperative anxiety on postoperative outcome and sleep quality in patients undergoing laparoscopic hysterectomy

Conditions: General Anesthesia; Postoperative Pain; Postoperative Sleep Quality; Preoperative Anxiety

Summary: sleep is a naturally occurring state of decreased arousal that is crucial for normal immune and cognitive function. although surgery and anesthesia techniques have improved in recent years, sleep function and sleep cycles may still be altered perioperatively by surgery and other interventions under general anesthesia.postoperative sleep fragmentation and poor sleep quality not only lead to hyperalgesia and delayed postoperative recovery, but can increase the risk of potential adverse effects, such as cognitive impairment, chronic pain and emotional disturbances, metabolic disorders, and pro-inflammatory changes. general anesthesia is a medically induced state of hyporesponsiveness that resembles natural sleep. studies have shown that general anesthesia can lead to circadian rhythm time structure dyssynchrony, resulting in postoperative sleep disturbance, characterized by decreases in rapid eye movement (rem) and slow wave sleep (sws). previous studies have also reported that age, preoperative comorbidities, and severity of surgical trauma are independent factors associated with postoperative sleep disturbance. in addition, anxiety is an unpleasant sensation that compromises patients' comfort and well-being. a study by ruis et al. estimated that 25-80% of patients admitted for surgery experienced preoperative anxiety, including fear of surgery and anesthesia-related fears. furthermore, preoperative anxiety was recognized as a potential and preventable risk factor for severe postoperative pain and postoperative complications such as increased postoperative morbidity and mortality. given that several prior studies have reported that preoperative anxiety has an effect on postoperative sleep quality in patients undergoing gynecological surgery, this study aimed to investigate the effect of preoperative anxiety on postoperative outcomes and sleep quality in patients undergoing gynecological surgery. studying these results could enable us to better manage patients during the perioperative period to promote their postoperative recovery.


Eligibility criteria:
the inclusion criteria were: 1. age between 18 and 75 years, 2. american society of anesthesiologists (asa) medical status i or ii, 3. laparoscopic hysterectomy, elective operation and surgery lasting 1-3 h. the exclusion criteria included 1. cardiovascular disease, 2. chronic use of analgesics, 3. chronic use of antidepressants, 4. use of sleep-promoting drugs, 5. sleep disorders, 6. sleep apnea syndrome, 7. history of abnormal surgery or recovery from anesthesia, 8. psychosis, 9. patients with impaired verbal communication, 10. unwillingness to provide informed consent.
intranasal fentanyl in treatment of labour pain

Conditions: Labor Pain

Summary: physiological changes during pregnancy are known to affect the pharmacokinetics of many drugs. intranasal fentanyl is an interesting option for obstetric analgesia, but its use in pregnant patients has not been established. the investigators studied pharmacokinetics of intranasal fentanyl in labouring women and to subsequently evaluate the maternal and fetal safety after administration.


Eligibility criteria:
inclusion criteria: * healthy parturients with uncomplicated, single gestation pregnancies, full term (38-42 weeks of gestation) pregnancy, agreed to participate exclusion criteria: * a disease that might affect hepatic or renal function, contraindications to opioid analgesics, fetal growth retardation, signs of fetal asphyxia by cardiotocography, meconium stained amniotic fluid or placental insufficiency. the subjects should not have received fentanyl during the previous 14 days. not agreed to participate

Keywords: labor pain fentanyl transmucosal
effects of psychoeducation of relatives to patients with serious mental illness

Conditions: Mental Disorder; Depressive Disorder; Schizophrenia

Summary: the purpose of this study is to determine the effects of psychoeducation for relatives to patients with serious mental illness.

the main aim of the study is to compare the effects of group psychoeducation for relatives to patients with serious mental illness with a waiting list control group. the main hypothesis is whether psychoeducation in groups has effects on the stress experience and coping style in the relatives. the relatives will receive group education in 6 weekly sessions. we will measure stress experience, coping style and the relatives' health condition before the sessions, after the sessions and at one year follow-up.

Eligibility criteria:
inclusion criteria: * relatives to patients having a psychotic or bipolar disorder * good norwegian language skills * consent to participate * the patients' consent for their relatives to participate

Keywords: family coping skills psychoeducation stress, psychological health education
pediatric tonsillectomy pain reduction study

Conditions: Postoperative Pain

Summary: tonsillectomy is associated with a significant decrease quality of life in children secondary to pain, which is worsened with swallowing. the objective of the current study is to conduct a prospective, double-blind, placebo-controlled, randomized clinical trial using a pre-tonsillectomy infiltration of the tonsillar fossa comparing three treatment regimens in reducing post-tonsillectomy morbidity (i.e. pain, poor oral intake): 1) placebo (saline injection) 2) bupivacaine (0.5%) + lidocaine (1%), 3) bupivacaine (0.5%) + lidocaine (1%) + clonidine (25 µg).

tonsillectomy is associated with a significant decrease quality of life in children secondary to pain, which is worsened with swallowing. previous studies in the pediatric population have demonstrated a significant decrease in post-operative pain/morbidity when administering pain reduction medications into the tonsillar fossa prior to removal. while these studies have shown great promise, no large randomized trial of the most promising medications has been conducted. because of this, many otolaryngologists do not administer intra-operative medications aimed at reducing post-operative pain. the objective of the current study is to conduct a prospective, double-blind, placebo-controlled, randomized clinical trial using a pre-tonsillectomy infiltration of the tonsillar fossa comparing three treatment regimens in reducing post-tonsillectomy morbidity (i.e. pain, poor oral intake): 1) placebo (saline injection) 2) bupivacaine (0.5%) + lidocaine (1%), 3) bupivacaine (0.5%) + lidocaine (1%) + clonidine (25 µg).

Eligibility criteria:
inclusion criteria: * age 3 - 17 years old * bmi \< 35 * negative pregnancy test in female patients age 10 and older * diagnosed with adenotonsillar hypertrophy, recurrent adenotonsillitis or upper airway obstruction and will be undergoing tonsillectomy alone or adenotonsillectomy exclusion criteria: * diagnosis of obstructive sleep apnea * patient with peritonsillar abscess * allergy to study medication * any major systemic illness, genetic disorder or diagnosed syndrome * bleeding disorder

Keywords: tonsillectomy postoperative pain clonidine anesthetics, local
dietary acid load during pregnancy and gestational diabetes mellitus

Conditions: Diabetes, Gestational; Dietary Habits

Summary: dietary habits resembling western style, rich in animal protein and poor in fruit and vegetables, increase the body acid load, a predictor of type 2 diabetes risk. recently, the studies related to relationships between dietary acid load and insulin resistance has become a growing interest but there are only a few study conducted with gestational diabetes mellitus (gdm). therefore, the aim of this study was to evaluate the potential relationship between dietary acid load in second trimester, blood lipid profiles and gdm.

this cross-sectional study conducted with 40 women with gdm diagnosed with two-step 100g oral glucose tolerance test and 40 healthy women, aged 21-41 years, between weeks of 14-28 of pregnancy, who attended the department of obstetrics and gynecology of gulhane training and research hospital. participants with polycystic ovary syndrome, chronic diseases, pre-gdm, or multiple pregnancies were excluded. sociodemographic information was recorded via questionnaire and anthropometrics of women were measured. blood samples were taken after an overnight fasting. dietary information was obtained by mean intakes of a 3-day food records (2 weekdays and 1 weekend day) and analyzed via nutrition analysis software. according to the data obtained from software analysis, animal protein (g/day) to potassium (g/day) ratio (ap/k), potential renal acid load (pral; meq/day) score and net endogenous acid production (neap; meq/day) were calculated from established algorithms to estimate dietary acid load. all nutrients were age and energy- adjusted before being introduced into the equation and tertiles of the scores were used for statistical analysis. anova, ancova and logistic regression test were used. the study plan was approved by the hospital\&#39;s ethics committee.

Eligibility criteria:
inclusion criteria: * singleton pregnancy, * aged in 20-40 years, * gestational age 24-28 weeks, * non-history of acute or chronic diseases. exclusion criteria: * history of gdm, * type 1 and 2 diabetes mellitus, * preeclampsia, * polycystic ovary syndrome, * thyroid disease * parathyroid disease, * metabolic bone disease, * kidney disease, * abnormal liver function, * multiple pregnancy * extreme values of energy intake in their dietary records (\ 4000 kkal).

Keywords: gestational diabetes mellitus dietary acid load pregnancy
arch bars vs. imf (intermaxillary fixation) screws: cost effectiveness based on time duration of device placement.

Conditions: Mandible Fracture

Summary: determining the cost effectiveness, based on the time duration of application, of two methods of wiring the jaws together during surgery to repair mandible fractures. one technique is more expensive but faster in application, while the other is less expensive and takes more time to apply.

purpose: to identify which option of wiring the jaws together during treatment of mandible fractures is more cost effective to the patient, erich arch bars or imf (intermaxillary fixation) screws. patients who sustain mandible fractures that meet the inclusion criteria will be randomized to one of the two treatment types listed above. the overall treatment in both categories is consistent with the standard of care, the only difference being the method utilized to achieve intermaxillary fixation during the course of the surgery.

Eligibility criteria:
inclusion criteria: * patients aged 18-70 * patients with no greater than one (1) open fracture of the tooth-bearing mandible * mandibular angle fractures ± ramus or subcondylar fracture * body/symphysis ± subcondylar * isolated angle fracture * isolate subcondylar fractures * bilateral subcondylar fractures * any condylar head/neck fracture requiring treatment * patients who are candidates for treatment of their fractures in the operating room setting exclusion criteria: * patients younger than 18 or older than 70 * patients with developing tooth buds anterior to the second molars * patients with inadequate stability of occlusion * edentulism * unstable vertical and horizontal stops to the occlusion * patients with disorders affecting bone healing, metabolism and turnover * those patients on bisphosphonates, oral or iv * patients with evidence of intrabony pathology of the mandible or maxilla * the presence of any of the following: * greater than one (1) open fracture of the tooth-bearing mandible * bilateral angle fractures are exempt from this * comminuted fractures of the mandible * concomitant infection, or osteomyelitis of the mandible * mechanism of injury * pathologic fracture * gun-shot wounds
daily activity after corticosteroids injection among knee osteoarthritis patients

Conditions: Knee Osteoarthritis

Summary: the objective of this study was to objectively measure daily physical activity and spatiotemporal gait pattern, as well as improvements in self reported symptoms and quality of life, before and six weeks after an intra-articular corticosteroids injection in patients suffering from knee osteoarthritis. fourteen patients with unilateral knee osteoarthritis were recruited. the intra-articular corticosteroid injection was given at the end of the second week. physical activity was objectively measured by an accelerometer worn by the participants for eight weeks. in addition, the western ontario and mcmaster universities arthritis index (womac), the medical outcome study short form-36 (mos-sf36) and gait trials were completed every two weeks to assess symptoms, quality of life and spatiotemporal parameters of gait.


Eligibility criteria:
inclusion criteria: * 50 years old or more * medial knee osteoarthritis (kellgren \& lawrence grade i to iii) exclusion criteria: * intra-articular injection during the last six months * isolated femoro-patellar arthritis * rheumatoid arthritis * knee instability * spinal stenosis * lower limb fracture over the last year * lower limb surgery in the last three months
azd2423 safety and tolerability study in patients with moderate and severe chronic obstructive pulmonary disease(copd)

Conditions: Chronic Obstructive Pulmonary Disease; Lung Disease

Summary: the purpose of the study is to investigate the tolerability and safety of azd2423 in patients with chronic obstructive pulmonary disease.


Eligibility criteria:
inclusion criteria: * male or female of non-child bearing potential. only women of non-child bearing potential are included in the study i.e. women who are permanently or surgically sterilised or post menopausal. * between 40 and 80 years of age at visit 1 * clinical diagnosis of copd (gold stage 2 or 3) * fev1/fvc \<70% and fev1 between 30 and 80% of the predicted normal post-bronchodilator (gold stage 2 or 3) * current or ex-smokers exclusion criteria: * any clinically significant disease or disorder (including history of abnormal immune function) which, in the opinion of the investigator, may either put the subject at risk or influence the way the drug works * any lung disease other than copd, recent respiratory infections which have not resolved fully, active tuberculosis or at risk of reactivation of tuberculosis. * any abnormal findings in physical examination, blood or urine test results, vital signs or ecg at visit 1 that may put the subject at risk during the study, affect their ability to take part or influence the results of the study * immunisation with a live vaccine within 3 months or other vaccination within 30 days before planned start of treatment * worsening of copd symptoms within 4 weeks prior to start of study needing hospitalisation, oral steroids or antibiotics.

Keywords: respiratory disease chronic obstructive pulmonary disease
impact of high-fat meals varying in fatty acid composition on adipose and systemic metabolic-inflammatory responses

Conditions: Inflammation; Obesity; Inflammatory Response; Cardiovascular Diseases; Overweight

Summary: cardiometabolic disorders are a leading cause of death worldwide. replacing saturated fatty acids (sfa) with unsaturated fatty acids is recommended as a way of lowering cardiometabolic disease risk. consuming a diet rich in sfa may lead to a greater metabolic-inflammatory response in white adipose tissue during the fasting state, when compared to eating a diet rich in monounsaturated fatty acids (mufa). since individuals spend most of the day in the fed (or postprandial) state, it is important to see how different types of dietary fatty acids affect postprandial white adipose tissue and systemic metabolic-inflammatory responses. this study will investigate the effect of a sfa-rich meal on markers of white adipose tissue and systemic metabolic-inflammation, compared to a mufa-rich meal in overweight adults. in a randomised, single blind controlled, cross-over manner participants will consume either a sfa- or mufa-rich meal and sequential blood and white adipose tissue samples will be collected before and until 6 hours postprandially.


Eligibility criteria:
inclusion criteria: * 18-50 years * bmi = 25-40 kg/m2 * male or female * waist circumference \>94 cm (men) and \>80cm (women)\* * physically active (\> 3 x 30 min moderate intensity exercise per week) * systolic blood pressure \< 160 mmhg and diastolic blood pressure \< 100 mmhg * no cardiometabolic (e.g. heart disease, high blood pressure, type 2 diabetes) or inflammatory illness * note: if waist circumference falls below 94 cm for men or 80cm for women but bmi is \>25 kg/m2 volunteers may still be recruited at the pi's discretion. exclusion criteria: * smoker * previous diagnosis of anaemia * women who are pregnant or lactating * taking medication known to interfere with study outcomes (e.g. treatment for hyperlidaemia, hypertension, inflammation or hypercoagulation) or prescribed antibiotics within the last 3 months * taking nutritional supplements known to interfere with study outcomes (e.g. fish oil or evening primrose oil) * unstable weight history (\>3 kg loss or gain in the previous 3 months) * an allergy to lidocaine * those with known or suspected food intolerances, allergies or hypersensitivity to any components of the meal (e.g. lactose/wheat intolerance) * alcohol consumption \>28 units per week for a man or \>21 units per week for a woman * any other unusual medical history or diet and lifestyle habits or practices that would preclude volunteers from participating in a dietary intervention or metabolic study * parallel participation in another intervention study