Kornimate/medical-research-clean huggingface dataset:
the effects of radial and focused extracorporeal shock wave therapies on lateral epicondylitis

Conditions: Lateral Epicondylitis; Pain

Summary: to date, focused and radial types of extracorporeal shock wave therapy have been effectively used in lateral epicondylitis. however, studies directly addressing a comparison between radial and focused types of extracorporeal shock wave therapy in lateral epicondylitis have not been done. therefore, this study aims to evaluate comparative effects of radial and focused extracorporeal shock wave therapy options on lateral epicondylitis.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of lateral epicondylitis * be aged ≥18 at the time of diagnosis * be give informed consent exclusion criteria: * be have not completed the assessment process. * elbow deformity * psychological illness
comparative effects of neuromuscular training vs close chain exercises in athletes with post operative acl injury

Conditions: Sports Physical Therapy

Summary: the aim of this study is to determine the effects of close chain exercises and neuromuscular training on pain, range of motion, strength and endurance in athletes with post operative acl injury the study will be randomized control trial with the sample size of 36. subjects will be enrolled according to inclusion and exclusion criteria. patients will be divided into two groups, each with 18 patients. group a will receive neuromuscular training while group b will receive close chain exercises. the participants will receive treatment sessions over 6-week period. the treatment session will be of 60 minutes with a warm up and cool down period of 10 minutes. outcome measures in both groups will be assessed by international knee documentation committee evaluation form. score for function, numeric pain rating scale (nprs) for pain, goniometer to measure range of motion, single leg hop, squats, triple jump test, push ups for strength and endurance respectively.

objective of my study is to compare the effects of neuromuscular training vs close chain exercises on pain, range of motion, strength and endurance in athletes with post operative acl injury

Eligibility criteria:
inclusion criteria: * athletes aged 18 to 35 years * 6-9 months after acl reconstruction * athletes who sustained unilateral acl injury treated surgically * athletes returning to sports * minimal to no knee effusion * normal knee range of motion * willing to take post-operative exercise program exclusion criteria: * history of lower extremity fractures surgery or traumatic injuries * neuromuscular disease * systemic disease * patients who had history of prior knee surgery were excluded

Keywords: acl neuromuscular exercises close chain exercises pain range of motion strength endurance athletes post operative
air purifier to improve endothelial function and carotid intima thickness

Conditions: Endothelial Function; Cognitive Impairment

Summary: background: there is epidemiological evidence or link ambient air pollution exposure to the incidence of dementia. aims or hypotheses: it is hypothesized that reduction in indoor pollutants from air purification improves endothelial function and carotid intima thickness in older diabetic people with cognitive impairment. subjects and method: people with clinically diagnosis mild cognitive impairment or early dementia will be recruited. after obtaining written consent, the subjects will be assessed cognitive function and arterial health. after baseline measurements, the subjects are randomly assigned to have either filter or no filter installed in the air purifier. the air purifier will be placed in living room of the household of the subject for one year. at one year, the measurements will be repeated. statistical analysis: intention to treat analysis will be adopted.


Eligibility criteria:
inclusion criteria: * diabetic people * mild cognitive impairment or early dementia exclusion criteria: * current smoker * the presence of a smoker in the household * the absence of a reliable family caregiver * the lack of mental capacity to give informed consent
the effect of ablation of epidermal nerve fibers using capsaicin cream

Conditions: Pain

Summary: this is a study of epidermal (the outer most layer) nerve fibers (enfs) in the skin of the body; counts of which are used to determine a disease of nerves called "small nerve fiber neuropathy." capsaicin is approved by the food and drug administration (fda) for pain relief. since 0.1% capsaicin is known to cause ablation (removal) of enfs, this study will test whether such ablation results in relief of spontaneous pain, touch, or heat-pain.

on the first day, two areas of the skin of the subject's right abdomen will be marked and identified as sites a and b. each day for one week the subject will be asked to grade her degree of discomfort or pain from 1 to 10 at sites marked a and b every two hours beginning at 8 a.m. and ending at 10 p.m. each day except for saturday and sunday touch-pressure sensation will be evaluated using monofilaments and heat pain sensation at sites a and b. also evaluated will be touch pressure pain at each of these sites. on thursday of the first week 3 mm punch biopsies of the skin will be obtained from sites a and b and another 3 mm punch biopsy will be obtained on thursday of the following week from sites a and b. following the first biopsy, the experimental creams will be applied to sites a and b. one of the experimental creams contains 0.1% capsaisin in a bland cream. the second cream contains no capsaisin. 0.1% capsaisin is known to destroy the small fibers, especially pain fibers in the skin. both the investigators applying the cream and the subject will not know which experimental cream contains the capsaisin. the creams will be applied on thursday of the first week but only after all testing and skin biopsies have been done. the creams will be left in place except when testing is being done, and they will not be applied after the second set of skin biopsies has been obtained. the creams will be applied by the investigators and by the subject, care being taken so that the tube marked a is applied to the site marked a, and the tube marked b is applied to the site marked b. between application to the two sites, investigators and the subject will use different gloves and applicators, carefully washing their hands with soap and water between and after applications. the subject will be asked not to shower or to immerse herself in water but to use sponge baths, avoiding the tested areas, so that the cream does not move to other areas.

Eligibility criteria:
inclusion criteria: * pain syndrome * must be able to be in study for one week exclusion criteria: - not able to be in study for one week
current clinical practice in the management of atrial fibrillation in greece: the manage-af study

Conditions: Atrial Fibrillation

Summary: this is a multicenter, 1-year prospective, observational study of atrial fibrillation (af) in greece, designed to provide real world data regarding the characteristics of af patients in greece, as well as current clinical practices and adherence to the 2010 esc guidelines.


Eligibility criteria:
inclusion criteria: 1. patients aged ≥ 18 years with any type of af(first diagnosed, paroxysmal, persistent, long-standing persistent and permanent) according to the classification described in the recent esc guidelines. 2. all patients should give written informed consent to participate in the study. exclusion criteria: 1. patients anticipated life expectancy less than 1 year due to a severe concomitant disease. 2. participation in an another clinical trial, with the exception of epidemiology trials (observational) that do not influence af management. 3. patients with mental disability unable to comply with follow - up visits and these who are unable to provide, in written, their informed consent or patients with anticipated inability to adhere to scheduled follow up visits.

Keywords: atrial fibrillation af
optimal blood pressure treatment thresholds postpartum

Conditions: Hypertensive Disorder of Pregnancy; Pre-Eclampsia; Hypertension; Eclampsia; Gestational Hypertension; Cardiovascular Diseases; Toxemia; Pregnancy Complications; Vascular Diseases; Hypertension, Pregnancy Induced; Hypertension;Pre-Eclamptic

Summary: the objective of this research project is to conduct a single-site pilot trial within our institution's clinical remote blood pressures (bp) management program to assess the feasibility and effect of tight blood pressure control versus usual care in the immediate postpartum period after a hypertensive disorder of pregnancy (hdp). the investigators' central hypothesis is that tight blood pressure control will be feasible and acceptable to postpartum individuals and will result in lower bp at six months postpartum and a reduction in postpartum hospital readmissions. subjects will undergo 3 study visits (1 in-person and 2 remote) involving bp measurements, blood draws, and/or questionnaires. up to 60 adult subjects will be enrolled at magee-women's hospital.

the investigators will determine the feasibility of conducting a randomized controlled trial of tight blood pressure control (\<135/85 mmhg on home bp monitoring) vs. standard of care (\<150/100 mmhg on home bp monitoring) in postpartum individuals following a hdp with assessment of individuals who are eligible, enrolled, and remain in the study until six weeks postpartum. individuals who are retained in the study for 6 months postpartum. lastly, investigators will analyze effect outcomes to inform the sample size for a subsequent large-scale randomized trial. this will be done through analysis of mean arterial pressure (map), systolic blood pressure, and diastolic blood pressure of participants at 6 weeks and at 6 months postpartum. the study will be conducted on the postpartum unit of magee-womens hospital. participants will be enrolled at the time of postpartum hospitalization with study visit #1 occurring in the hospital. at this study visit, participants will be administered questionnaires, will provide a blood sample, and bp will be measured. study visit #2 will be a remote study visit conducted via telemedicine or a telephone call at 6 weeks postpartum. at this visit, participants will provide questionnaires and blood pressure data. study visit #3 will be a remote study visit conducted via telemedicine or a telephone call at 6 months postpartum. at this visit, participants will again provide questionnaires and blood pressure data.

Eligibility criteria:
inclusion criteria: * postpartum individuals ≥18 years old * preeclampsia or gestational hypertension diagnosis (complying acog criteria) * enrolled in remote bp management program. exclusion criteria: * pre-pregnancy hypertension * pre-pregnancy diabetes * maternal cardiac disease * chronic kidney disease

Keywords: hypertension
dulaglutide in diabetic patients, relationship between arterial stiffness, endothelial function, clinical and laboratory variables

Conditions: Diabetes Mellitus

Summary: the study aims to evaluate arterial stiffness and endothelial function indexes and their relationship with clinic and laboratory varible in a group of diabetic patients in treatment with dulaglutide

46 patients with type 2 diabetes mellitus were recruited at the internal medicine with stroke care ward of the university hospital of palermo "p. giaccone" from april 2017 to april 2018. for all patients treatment with dulaglutide was undertaken. as control group were recruited 46 patients from the same ward not affected by diabetes mellitus or affected by diabetes mellitus but not in treatment with dulaglutide. the study was carried out in accordance with the principles of the helsinki declaration revised in 2001 and all patients gave their written consent to take part in this research. each patient treated with dulaglutide was compared for age, sex and cardiovascular risk with control patients. the diagnosis of type 2 diabetes mellitus was based on the revised criteria of the american diabetes association (ada), and using a clinical algorithm that considered the age of onset of the disease, the symptoms and weight present, the family history and the therapy practiced. arterial hypertension was defined according to the 2017 esc-esh criteria. dyslipidemia was defined based on total cholesterol levels\> 200 mg/dl, triglycerides\> 150 mg/dl and hdl levels \<40 mg/dl regardless of the patient's gender. among the cases enrolled, 46 (100%) had type 2 diabetes mellitus, 37 (80.43%) had arterial hypertension and 26 (56.52%) hypercholesterolemia. clinical and anthropometric data were collected at the time of recruitment. blood samples were taken from each patient (cases and controls) to determine serum glucose, hba1c, total cholesterol, hdl and ldl cholesterol, triglycerides, creatinine, and a urine sample to assess the presence of microalbuminuria. these withdrawals were then repeated three months and nine months from the time of recruitment. the digital endothelial function was evaluated through the rhi-pat analysis using endo-pat2000. pulse wave velocity (pwv) carotid-femoral pulse was measured in the supine position using an automatic device (sphygmocor version 7.1) that evaluated the propagation time of the sphygmic wave between the carotid and femoral pulse.

Eligibility criteria:
inclusion criteria: * diabetes mellitus exclusion criteria: * cancer, severe ckd, end stage liver disease

Keywords: diabetes mellitus dulaglutide endothelial function
perception and prevalence of fungal infections in berlin - brandenburg

Conditions: Invasive Mycosis

Summary: this is a structured web-based survey in selected hospitals with intensive care units in berlin- brandenburg that will focus on the analysis of current knowledge in icus in the field of invasive mycoses.

intensive care patients with invasive mycosis require a special clinical expertise especially in light of a high lethality. early identification of patients at risk to develop a fungal infection is of utmost importance to start effective antifungal therapy. the implementation of current knowledge into clinical practice to fight fungal infection is not clear.

Eligibility criteria:
inclusion criteria: * intensive care units of hospitals in the inabbra alliance. * patients with invasive mycosis. exclusion criteria: * hospitals without intensive care unit.

Keywords: intensive care candidemia fungal infection
immune responses in prostate, lung, melanoma and breast cancer patients following stereotactic body radiotherapy (sbrt), intensity modulated radiotherapy (imrt) or brachytherapy

Conditions: Prostate Cancer; Breast Cancer; Lung Cancer; Melanoma

Summary: success of cancer immunotherapy is limited by the ability of solid tumors to evade local and systemic antitumoral immune responses. several mechanisms of tumor immune evasion have been identified, including low intratumor expression of antigens and elevated expression of inhibitory co-regulatory molecules. an effective immunotherapy is one which would induce necrotic cell death and accompanying proinflammatory cytokine induction. stereotactic body radiotherapy (sbrt) or intensity modulated radiotherapy (imrt) or brachytherapy, which is capable of delivering high, conformal radiation doses (\>8 gy) of tumor ablative radiation may be an effective means of conditioning a tumor bed to a state favorable to the initiation of robust antitumoral immune responses.


Eligibility criteria:
inclusion criteria: * hormone refractory, metastatic prostate cancer, lung cancer, and melanoma or breast cancer exclusion criteria: -life expectancy of less than 3 months
performance of multi-cancer early-detection based on various biomarkers in female breast cancers, perceive-breast

Conditions: Cancer

Summary: this study is a retrospective and prospective study aimed to develop and validate the performance of multi-omics assays for early detection of female breast cancer. the study will enroll approximately 496 participants including participants with breast cancers and participants with breast benign diseases.


Eligibility criteria:
inclusion criteria for all participants: * able to provide a written informed consent. * female, at least 18 years old. additional inclusion criteria for breast cancer participants: * pathologically confirmed breast cancer diagnosis or highly suspicious for breast cancer within 42 days prior to blood draw. * no prior cancer treatment before the blood draw. additional inclusion criteria for breast benign disease participants: * pathologically confirmed breast cancer diagnosis or highly suspicious of breast benign diseases within 90 days prior to blood draw. * no prior radical treatment before the blood draw. exclusion criteria for all participants: * during pregnancy or lactation. * recipient of organ transplant or prior non-autologous (allogeneic) bone marrow or stem cell transplant. * recipient of blood transfusion within 7 days prior to blood draw. * recipient of anti-tumor drugs to treat non-cancer diseases prior to blood draw, such as rheumatic drugs (methotrexate, cyclophosphamide, or azathioprine), or endocrine drugs (tamoxifen). additional exclusion criteria for breast cancer participants: * multiple primary tumors.

Keywords: cancer liquid biopsy early detection cell-free dna methylation
effects of gargling with green tea on oral health of stroke patients

Conditions: Oral Health

Summary: 1. compare the effects of gargling with green tea on the oral health of stroke patients? 2. compare whether gargling with green tea can reduce halitosis in stroke patients? 3. compare whether gargling with green tea can reduce plaque index in stroke patients?

before the intervention of green tea mouthwash, patients in the experimental group and the control group were tested for oral health status, bad breath and plaque degree, and received routine brushing guidelines. patients in the experimental group received green tea mouthwash intervention twice a day for 7 day

Eligibility criteria:
inclusion criteria: * hospitalized patients over 20 years of age with acute cerebral stroke admitted by medical institutions. * stroke patients diagnosed by medical institutions were treated with the national institute of health stroke scale; nihss) score is 5-15, which is a moderate degree of stroke * able to perform mouthwash. * those who have passed the three-stage swallowing function screening. * those with stable medical condition. exclusion criteria: * those who of medical institutes in the diagnosis of severe alzheimer.(icd-10 code： g30.9) * those who severe mental retardation. * those has a history of mental illness. * those has unable to clearly express their wishes. * those has full mouth teeth less than six. * those has in the past more than a month use mouthwash. * those has treatment of the patients with gingivitis and periodontal disease, oral antibiotics or anti-fungal drugs. * those has unable to cooperate or applicable except of assessment tools.

Keywords: green tea gargling oral health stroke patients
effect of proton pump inhibitors on gut microbiota and systemic inflammation in older adults

Conditions: Healthy Volunteers

Summary: the purpose of this study is to evaluate the effects of a common over-the-counter medication, omeprazole, on the normal gut bacteria and inflammation in the body in healthy older adults.

this study aims to enroll 25 healthy subjects from san antonio, texas and the surrounding area. study participants will be asked to provide a blood and stool sample at baseline, complete a 14-day course of omeprazole (prilosec®), and then complete a follow-up blood and stool sample.

Eligibility criteria:
inclusion criteria: * age 60 years or older exclusion criteria: * no prior major gastrointestinal surgery * no chronic daily use or any use within the past two months of the following medications: antibiotics, proton pump inhibitors, other acid reflux medications, probiotics, anti-inflammatory medications, anti-diarrhea medications, laxatives, anti-depressants, anti-anxiety medications, steroids, metformin, or biologic/immune modulating drugs
a randomized-controlled trial to investigate the effect of a novel music therapy application to reduce anxiety and stress

Conditions: Anxiety; Depression; Stress

Summary: this virtual, open-label, three-group, randomized-controlled trial will last six weeks. participants will be allocated into three groups; the intervention group, spotify group, and control group. all participants will complete a baseline questionnaire before completing their designated regime daily for six weeks. in addition, participants will complete study-specific surveys and validated questionnaires at the end of each week (week 1, 2, 3, 4, 5 \& 6). the study will include 75 \[participants in total, 25 per group, who all have self-reported concerns around anxiety, stress, or depression. questionnaires will be used to monitor sleep, cognitive ability, and changes in symptoms of anxiety, depression, and stress. both study-specific questionnaires and validated questionnaires will be utilized, including the generalized anxiety disorder assessment (gad-7), the 9-question patient health questionnaire (phq-9), perceived stress scale (pss), and the world health organisation- five well-being index (who-5). likert scale responses will be examined from baseline to each check-in. participant responses on product feedback will be presented as % scores.


Eligibility criteria:
inclusion criteria: * male or female * between 18-28 years of age * self-reported concerns around anxiety, stress, or depression * generally healthy - don't live with any uncontrolled chronic disease * must have headphones exclusion criteria: * any pre-existing chronic conditions that would prevent participants from adhering to the protocol, including oncological and psychiatric disorders * women who are pregnant, breastfeeding or attempting to become pregnant * unwilling to follow the study protocol * testing any other product for any other research studies at the same time * history of epilepsy or seizures
chemoprevention of esophageal squamous cell carcinoma (escc) with aspirin and tea polyphenols

Conditions: Carcinoma, Squamous Cell

Summary: evidence from laboratory studies suggests that aspirin and tea polyphenols may have an antineoplastic effect in esophageal squamous cell carcinoma (escc). to assess the safety and efficacy of aspirin and tea polyphenols for preventing escc, the investigators designed this double-blind, randomized controlled clinical trial. research project is planned to recruit 10,000 participants with the ages of 40-60 years in fengfeng city, hebei province, china, which has been known as a high incidence region of escc. all the participants receive endoscopic examination. lugol's chromoendoscopy is used to identify esophageal unstained lesions (usls). the location and size of each usl will be recorded followed by collecting biopsy samples from each usl. participants with usl are randomly assigned to receive 100 mg/d of aspirin (n=200), 100 mg/d of tea polyphenols (n=200), or placebo (n=200) for six months. follow-up consists of 2 endoscopic surveillance cycles (the first interval will be at six months and the second at 3 or 5 years later). the primary outcome measure was occurrence of high grade dysplasia and invasive escc. secondary outcome was the mortality of the participants and adverse events.


Eligibility criteria:
inclusion criteria: 1. age 40 to 60 years; 2. lugol's chromoendoscopy showing at least one usl 1 cm or larger containing mild to moderate dysplasia and chronic inflammation; 3. subject neither pregnant nor intending to become pregnant during the study. exclusion criteria: 1. current non-steroidal anti-inflammatory drugs (nsaid) therapy; 2. major intercurrent illness; 3. pregnancy; 4. invasive carcinoma; 5. any condition that could be worsened by aspirin or tea polyphenols.

Keywords: aspirin polyphenols chemoprevention