Kornimate/medical-research-clean huggingface dataset:
trunk stabilization exercises at lipoedema patients

Conditions: Lipedema

Summary: lipedema is a chronic, progressive adipose tissue disorder that is mostly seen as a symmetrical growth of the hips and legs, affecting women. the aim of this study is to investigate the effect of trunk stabilization exercises in addition to active range of motion exercises on body composition, pain, edema, trunk endurance, functional capacity and postural stability.

thirty female patients with upper and lower leg lipedemia were included in the study. subjects were divided into two groups as experimental (n = 15) and control (n = 15). the physiotherapy program of the control group will consist of active range of motion exercises and the physiotherapy program in the experimental group will include active range of motion exercises as well as trunk stabilization exercises. after recording demographic data of all subjects, limb volume (environmental measurement), body composition analysis, trunk endurance, pain (visual analogue scale), postural stability (biodex balance system®) and functional capacities (6-minute walk test) will be taken. after the six-week treatment program, all evaluations will be repeated. spss (spss 21.0) program was used for statistical analysis of the data. significance level in all analyzes will be accepted as p \<0.05.

Eligibility criteria:
inclusion criteria: * diagnosed with lower or upper type lipedema * to be able to understand turkish * being older than 18 years exclusion criteria: * diagnosed with vestibular disorders * having orthopedic or neurologic co morbidities

Keywords: lipedema postural stability trunk stabilization exercises
north american comfilcon a clinical study

Conditions: Astigmatism; Presbyopia; Ametropia

Summary: the main objective of this study is to demonstrate acceptable safety and effectiveness (performance) of comfilcon a sphere, toric, multifocal, toric multifocal and energys lenses, when used in the general population.

the main objective of this study is to demonstrate acceptable safety and effectiveness (performance) of comfilcon a sphere, toric, multifocal, toric multifocal and energys lenses, when used in the general population after 2 hours of wear.

Eligibility criteria:
inclusion criteria: 1. age 8 to 75 years (inclusive). 2. current wearer of the comfilcon a sphere, toric, multifocal, toric multifocal or energys contact lens for at least 12 months. 3. at least occasional overnight wear in the last 12 months. exclusion criteria: 1. current participation in a contact lens or contact lens care product clinical trial.
the detection of circulating tumor cells (ctcs) in patients with lung cancer undergoing cryosurgery combined with dc-cik treatment

Conditions: Neoplastic Cells, Circulating

Summary: circulating tumor cells (ctcs) have the potential to provide a surrogate for'real-time biopsy' of tumor biological activity. enumeration and molecular characterization of ctcs in lung cancer could play an important role in diagnosis, predicting the risk for tumor recurrence, and providing novel target therapy biomarkers. in view of these facts, the investigators wanted to demonstrate the value of multiparameter flow cytometry in detecting human tumor cells of lung cancer in normal peripheral blood after cryosurgery with or without dendritic cell(dc)-cytokine-induced killers(cik) treatment, and the investigators also compared the specificity with reverse transcriptase polymerase chain reaction (rt-pcr) method.

1 day before and 2 days after cryosurgery with or without dc-cik treatment，approximately 17-ml ethylene diamine tetraacetic acid(edta)-blood was drawn by vein puncture from patients with lung cancer and healthy volunteers. the blood of the healthy volunteers will be used to evaluate the sensitivity and specificity and as negative control cells. to avoid contamination with skin cells, 2 ml blood will be discarded before the study samples will be taken.briefly, the mononucleate cells will be separated from the blood over ficoll- paque for 20 min with 1800g at 4℃. the interface cells will be removed and washed, and the red blood cells(rbcs) will be removed using a lysis buffer followed by a repeated wash. the mononuclear cells will be counted and aliquot for rt-pcr and multiparameter flow cytometry on the basis of at least 2-3×106 cells for each methodology. the cell pellet will be resuspended in phosphate-buffered saline for multiparameter flow cytometry and in trizol reagent for rt-pcr. aim : identification of ctcs may lead to better diagnosis and prognosis and could help to choose an adequate therapy.

Eligibility criteria:
inclusion criteria: 1. age:18-75 2. karnofsky performance status \>60 3. diagnosis of lung cancer based on histology or the current accepted radiological measures. 4. classification tumor,nodes,metastasis-classification(tnm) stage: ⅱ,ⅲ,ⅳ 5. will receive cryosurgery and/or dc-cik treatment 6. life expectancy: greater than 3 months 7. patients' routine blood test, liver function and kidney function have no obvious abnormalities 8. ability to understand the study protocol and a willingness to sign a written informed consent document exclusion criteria: 1. patients with other primary tumor except lung cancer 2. history of coagulation disorders or anemia

Keywords: lung neoplasms circulating tumor cells
examining the effectiveness of a group cognitive-behavioural treatment program for persistent genital arousal disorder

Conditions: Persistent Genital Arousal Disorder

Summary: this study seeks to provide information regarding the effectiveness of a virtual, synchronous cognitive behavioural therapy (cbt) group program for women with persistent genital arousal disorder/genitopelvic dysesthesia (pgad/gpd). the program consists of 8 weekly sessions of two hours each, which focus on education and understanding, and learning skills and strategies to manage pgad/gpd symptoms, and related mental health and lifestyle impacts, as well as structured opportunities for discussion and shared reflection. the group therapy program involves elements based in cognitive behavioural therapy (cbt), acceptance and commitment therapy (act), and dialectical behaviour therapy (dbt). participants in the present study will provide responses to online surveys (before, during, and immediately after treatment, also 3 and 6 months after treatment) regarding their pgad/gpd symptoms, mental health symptoms, and sexual wellness (sexual pleasure and distress).


Eligibility criteria:
inclusion criteria: * at least 18 years of age * fluent in english * have a physician-based diagnosis of pgad/gpd * reside in ontario, canada * be comfortable answering questions about their health (mental and physical) and sexuality in online surveys * be comfortable discussing their mental and physical health and pgad/gpd symptoms in group online therapy sessions with video on exclusion criteria: * under the age of 18 years * nonfluent in english * lack of physician based diagnosis of pgad/gpd * not comfortable with answering questions about mental, physical, sexual health * not comfortable with discussing mental and physical health and pgad/gpd symptoms in group online therapy sessions with video on * mental or physical health conditions that preclude involvement in group therapy

Keywords: persistent genital arousal disorder intervention
a study to examine the efficacy and safety of meridia® (sibutramine hydrochloride) in binge-eating disorder

Conditions: Binge Eating Disorder; Obesity

Summary: the purpose of this study is to examine the safety and efficacy of sibutramine in preventing binge eating episodes. additionally the study aim is to evaluate the safety and efficacy of sibutramine in reducing body weight in subjects with binge-eating disorder.


Eligibility criteria:
inclusion criteria: * participants were men and women * between the ages of 18 and 65 * with body mass index (bmi) \<45 kg/m2 * who met dsm-iv criteria for bed exclusion criteria: * participants were excluded * for blood pressure \>140/90 mm hg * with pulse \>95 beats/min * history of stroke, narrow angle glaucoma, cardiac disease, seizures, renal or hepatic dysfunction * use of insulin, medications known to affect body weight, or certain psychoactive medications (monoamine oxidase inhibitors, lithium, ssris, opioids) * current participation in a weight loss program * surgical treatment for obesity * bulimia nervosa or purging in the past 6 months * alcohol or drug abuse in the past 12 months * current psychiatric condition being treated with a psychoactive agent * current major depressive disorder * history of anorexia nervosa, psychosis, bipolar disorder, or suicide attempts * psychotherapy within the previous 2 months * women were excluded if they were pregnant, lactating, or if fertile, not practicing adequate contraceptive precautions
long term study to evaluate the safety, tolerability and efficacy of fesoterodine for overactive bladder.

Conditions: Overactive Bladder

Summary: to assess the long term safety, tolerability and efficacy of fesoterodine in patients with oab.


Eligibility criteria:
inclusion criteria: * adult oab patients who present with oab symptoms, including micturitions \>= 8 per day and urinary urgency episodes \>=1 per day. exclusion criteria: * patient has known hypersensitivity to the active substance (fesoterodine fumarate) or to peanut or soya or any of the excipients. * patient has a known neurological disease influencing bladder function. * patient has a complication of lower urinary tract pathology potentially responsible for urgency or incontinence, clinically relevant bladder outlet obstruction or pelvic organ prolapse.
a double blind crossover study on the effect of mph on decision-making ability of adults with bpd compared to adults with adhd and healthy adults

Conditions: Borderline Personality Disorder

Summary: the study assesses the effect of ritalin on working memory,attention,and decision-making measures in adults with bpd and compares it to its effect on healthy adults and adults with bpd (using data form study sha 01-10), in a double-blind crossover design. the investigators hypothesize that ritalin will result in better performance in all measures.

participants will be required to arrive at the cognitive laboratory in "shalvata" for two visits: the first visit will include obtaining informed consent, screening (as detailed below), and performing a battery of computerized tasks. the second visit will include performing of the same battery of tasks, and payment. in one of the visits, participants will receive a capsule containing methylphenidate or placebo (mph; ritalin) (dosage: 10 mg in case weight\ 90 kg; otherwise 20 mg -( the pills will be 10mg each, and the number of pills will be administered according to the dosage stated; 1-3 pills, according to weight). prior to performing the tasks, and in the other visit they will receive a capsule containing placebo.

Eligibility criteria:
inclusion criteria: * adults in the age of 21-50 with diagnosed with borderline personality disorder (bpd) exclusion criteria: * people diagnosed with a clinical disorder other than bpd or add/adhd that may impair their performance in the tasks used in the study. * people for whom there is a contra-indication for consuming ritalin. * pregnant women and nursing women; women participants will be required to report whether they are pregnant, and in case they are, they will not participate.
ultrasound to prevent leg wound complications in heart bypass.

Conditions: Surgical Wound Infection; Coronary Artery Bypass

Summary: the long saphenous vein is traditionally harvested for use as a conduit in coronary artery bypass grafting surgery. currently, the long saphenous vein is not imaged prior to surgery. this study aims to evaluate preoperative ultrasound mapping of the long saphenous vein to to improve patient and clinical outcomes.

a vein from the leg is widely is widely harvested during coronary artery bypass grafting (cabg) surgery for bypass of diseased coronary arteries. this vein is called the long saphenous vein. currently, the long saphenous vein (lsv) is harvested blind by surgical practitioners with no imaging prior to surgery to decide on whether this vein is suitable for use in heart bypass surgery. this can result in fruitless incisions and result in additional unnecessary surgical wounds in the leg(s) to identify a suitable section of vein that can be used in the bypass operation. in these cases, excessive surgical trauma to the leg can increase the risk of a wound infection. there is some evidence that ultrasound imaging of the lsv improves leg wound outcomes in patients having cabg surgery. some studies have reported reductions in vein wound infection rates, vein harvest time, length of hospitalisation and length of wounds. the purpose of this study will be to investigate the potential benefit of ultrasound imaging as a randomised control trial. one group will have ultrasound imaging of the long saphenous vein prior to heart bypass surgery. a second group will not undergo ultrasound imaging which is current practice at the bristol heart institute. ultrasound imaging of the long saphenous vein will allow planning and selection of the most optimal segment of vein. this targeted approach will allow guidance of surgical incisions away from unsuitable segments and thus potentially improving leg wound outcomes. the primary endpoint for this study will be to assess leg wound infection between the two randomised groups. other endpoints that will be assessed are patient satisfaction, wound length, time taken to remove the vein, blood loss from the leg wound during surgery and the number of wounds in your leg.

Eligibility criteria:
inclusion criteria: * listed for cabg surgery with long saphenous vein harvesting. * aged over 18 years. * capable of providing informed consent. * five days or more to consider participation prior to surgery if an outpatient or 2 days if an inpatient referred by their consultant. * operative procedure to be undertaken at the bristol heart institute. exclusion criteria: * operation within 48h hours if an inpatient or 5 days if an outpatient. * aged below 18 years of age. * incapable of providing informed consent i.e. confirmed diagnosis of dementia or other mental health conditions or unconscious. * current participant in a different randomised control trial. * pregnancy * active cancer * immunosuppressed. * non-english speaker that requires a trust translator.

Keywords: surgical site infection long saphenous vein coronary artery bypass grafting
efficacy and safety study of diapep277 in newly diagnosed type 1 diabetes adults

Conditions: Type 1 Diabetes Mellitus

Summary: this study will look at the treatment effect of diapep277 on preservation of beta-cell function, as defined by meal-stimulated secretion of insulin. diapep277 is a peptide that changes the way the immune system behaves, stopping its attack on the beta-cells. adults (\>20 years) with newly diagnosed (\<6 months) type 1 diabetes will be treated with 10 injections of diapep277 or placebo over a 2-year treatment and follow-up period.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of type 1 diabetes within last 6 months * age 20-45 years * fasting basal c-peptide equal or greater than 0.22 nmol/l, lower than 0.8 nmol/l * bmi between 17 and 30 at screening exclusion criteria: * significant disease or condition other than type 1 diabetes * diabetes-related complications * ongoing treatment with immunosuppressive or immunomodulating agents including chronic corticosteroids

Keywords: beta-cells autoimmune diabetes immunomodulation
evaluation of nocturnal hypertension and correlation with target-organ damage

Conditions: Nocturnal Hypertension

Summary: the aim of this study is to evaluate nocturnal hypertension with 24-hour ambulatory blood pressure and home blood pressure (bp) measurements through a) comparison of mean bp and nocturnal dipping assessed with the two methods, b) correlation of those parameters with parameters of target-organ damage and c) comparison of the potential of the two methods to define non-dippers.

it is well known that blood pressure (bp) exhibits diurnal variation. nocturnal fall of bp normally exceeds 10%. subjects with such fall of bp during sleep are classified as "dippers" and those with a nocturnal fall of bp less than 10% are classified as "non-dippers". non-dippers are exposed to a greater cardiovascular risk. to date dipping status is defined with 24-hour ambulatory bp monitoring (abpm). many studies have shown that home bp monitoring (hbpm) can be an alternative to daytime ambulatory bp monitoring and it exhibits similar correlation to markers of hypertension target-organ-damage (tod). nocturnal hypertension shows closer correlation with tod, than daytime hypertension. in this study patients will be provided with a new-technology, reliable oscillometric device for hbpm, equipped with a modified algorithm, which allows scheduled automated bp measurements during sleep (microlife watchbp home nocturnal). duplicate morning and evening bp measurements with one-minute interval will be performed by the patient sitting during seven working days. afterwards a 24-hour abpm will be performed, using microlife watchbp o3 oscillometric device, with a 20-minute interval between measurements. this order may be reversed according to the wish of the patient and devices' availability. participants will visit site 3 times. office blood pressure will be measured during two visits. triplicate measurements with microlife watchbp home nocturnal will be performed at the sitting position. tod will be assessed with: * cardiac triplex (lvmi) * carotid triplex (ιμτ) * pulse wave velocity. * albumin/creatinine ratio measured in morning urine sample.

Eligibility criteria:
inclusion criteria: * mean 24-hour systolic bp (sbp) \>130 mmhg and/or mean 24-hour diastolic bp (dbp) \>80 mmhg. * patients physically and mentally capable of self-measuring bp at home. * written informed consent. exclusion criteria: * sustained arrhythmia. * pregnancy. * symptomatic cardiovascular disease. * any other serious illness (cardiac, renal, or malignancy).
clinical evaluation of the ravi-guide

Conditions: Retinal Diseases

Summary: hypothesis: the ravi-guide provides superior patient acceptability to the conventional lid speculum during intravitreal injections aims: to compare patient acceptance and procedural complication rates of the ravi-guide with those of the conventional lid speculum and caliper approach


Eligibility criteria:
inclusion criteria: * patients age 18 years or older who undergo intravitreal injection for clinical indications. exclusion criteria: * patients under the age of 18 years * patients unable to give informed consent * disorders that preclude the ability to judge pain or discomfort associated with intravitreal injection * disorders that preclude the ability to assess for complications of intravitreal injection * inability to assess the landmarks by which localization of intravitreal injection sites is determined, such as obscured corneal limbus * inability to communicate directly to the physician and immediately after the procedure the level of pain or discomfort
low intensity ultrasound in patients with carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: to investigate the influence of low intensity pulsed ultrasound on pain level, pinch grip strength, sensory distal latency of the median nerve, motor distal latency of the median nerve and hand function in patients with chronic carpal tunnel syndrome

carpal tunnel syndrome (cts) is an entrapment neuropathy caused by compression of the median nerve as it travels through the wrist's carpal tunnel. it is the most common nerve entrapment neuropathy, accounting for 90% of all neuropathies. early symptoms of carpal tunnel syndrome include pain, numbness, and paresthesia. these symptoms typically present, with some variability, in the thumb, index finger, middle finger, and the radial half (thumb side) of the ring finger. pain also can radiate up the affected arm. with further progression, hand weakness, decreased fine motor coordination, clumsiness, and thenar atrophy can occur. low-intensity ultrasound (liu) and low-intensity pulsed ultrasound (lipus) are known to have positive effects on dentin genesis, cell proliferation, protein synthesis, collagen synthesis, membrane permeability, and integrin expression and to increase cytosolic calcium levels.

Eligibility criteria:
inclusion criteria: 1. 26 male and 26 female patients have unilateral with mild to moderate cts in dominant hand diagnosed and referred by physician. 2. age will be ranged from 30-50 years 3. all patients have body mass index between 18.5 and 24.9 kg/m2 4. median nerve sensory distal latency \> 3.5 millisecond but not more than 4.5 millisecond, motor distal latency longer than 4.2 millisecond but not exceed 6.5 millisecond. 5. positive clinical manifestation (pain, paresthesia in the distribution of the median nerve for 6 months, positive tinel's and phalen's sign) exclusion criteria: 1. patients with diabetes mellitus ( type i or type ii), 2. patients with hypothyroidism 3. patients with rheumatoid disease 4. patients with renal disease 5. patients with polyneuropathy 6. patients with cervical radiculopathy 7. patients with wrist arthritis , wrist fracture and acute trauma 8. patients with carpal tunnel release surgery 9. patients with outlet syndrome 10. thenar muscle atrophy -