Kornimate/medical-research-clean huggingface dataset:
ex-vivo evaluation of the effect of 2 probiotic solutions (lactibiane atb and lactibiane enfant) and 5 classes of drugs on the intestinal microbiota

Conditions: Dysbiosis

Summary: the objective is to test ex-vivo the effects of two probiotic solutions (lactibiane atb and lactibiane enfant) and five classes of drugs (antibiotic, proton pump inhibitor, non-steroidal anti-inflammatory, anxiolytic and anti-depressant) on microbial microcosms derived from human stool samples (from adults and children) re-cultured under anaerobic conditions.


Eligibility criteria:
inclusion criteria: adult "mother" population: * women aged 25-40 years; * in good general health, i.e. no chronic pathology and not taking any medication at the time of inclusion and/or long-term treatment, * with a regular bowel movement frequency (at least once every 2 days) * bmi between 18.5 and 25 * able and willing to participate in the research by complying with the protocol procedures * not objecting to the collection and processing of their personal data child "daughter" population * girl between 1 and 2 years old * in good general health, i.e. no chronic pathology and not taking any medication at the time of inclusion and/or on a long-term basis, * with a regular stool frequency (at least once every 2 days) * whose mother does not object to the collection and processing of personal data exclusion criteria: adult "mother" population : * pregnant or breastfeeding women, * under antibiotic treatment, or having stopped it for less than a month. * under dietary supplementation (prebiotics or probiotics) or having stopped it less than one month before * on antidepressants and/or anxiolytics in the month before inclusion * taking a non-steroidal anti-inflammatory drug (nsaid) the month before inclusion. * on ppi, or having stopped it less than one month before. * persons under court protection, * person participating in another research study with an ongoing exclusion period, child "daughter" population: * outside the who normal growth charts (weight for height) for girls aged 0-2 years (below the 3rd percentile or above the 97th percentile) * undergoing antibiotic treatment, or having stopped it less than a month ago. * having taken a non-steroidal anti-inflammatory drug (nsaid) in the month prior to inclusion. * on dietary supplements (prebiotics or probiotics) or having stopped them within the last month * subjects participating in another research study with an ongoing exclusion period
optimized heart failure therapy through continuous monitoring

Conditions: Heart Failure

Summary: patients with heart failure have a high incidence of atrial fibrillation (af)and re-admission for heart failure. new methods have been developed to continuously monitor arrhythmia's and heart failure parameters. one such method is implantation of an implantable loop recorder. also home-monitoring is available for continuous monitoring and information sending to the treating physicians, with improving detection of atrial fibrillation (af) and/or other sever arrhythmia's we hope to improve patient care. objective of the study: to investigate the clinical efficacy in detecting clinically relevant arrhythmia's (especially af) of the reveal xt in patients with mild to moderate heart failure and elevated risk factor for stroke and transient ischemic attack (tia)(chads-score \>2), currently not treated with oral anticoagulation (oac). study design: in 50 stable sinus rhythm (no known af)patients with new york health association (nyha class) 2-3, a chads2-score\>2 and no indication for a implantable cardioverter-defibrillator (icd) or pacemaker (pm) or oac. patients are put on home-monitoring (carelink) and regular outward clinic visits. the number of relevant arrhythmia's detected will count for the primary endpoint. also the number of medication changes and institution of oac. study population: 50 stable patients, recruited from the outward clinic. nyha class 2-3. reveal xt implantation. chads2-score 2 or more. no indication for icd/pm or oac. no af known. primary study parameters/outcome of the study: primary endpoints * af burden and af episodes detected * detected other relevant arrhythmia's like svt's (not af) or ventricular tachycardias (vt's) or bradycardias * % patients on oac after 1 year follow-up * number of clinically relevant patient activated events * number of treatment policy changes based on the reveal xt secondary study parameters/outcome of the study * specificity of af detection algorithm by the reveal * predictive value of the cardiac compass data to predict worsening heart failure episodes.

no additional description needed

Eligibility criteria:
inclusion criteria: * ef \> 35% * nyha 2-3 * no af documented * not on oac exclusion criteria: * use of oac * documented af \> 30 sec * planned or actual pm/icd * life-expectancy \< 1 year * no informed consent

Keywords: heart failure implantable loop recorder
phase i study to evaluate the safety and pharmacokinetics of oral doses of anvylic-3288 in healthy subjects

Conditions: Schizophrenia

Summary: this is a brief inpatient study to determine the safety of a new drug in healthy people.

avl-3288, a "first in class" small molecule, selective allosteric modulator of the α7 nachr, is implicated in the cognitive deficit in patients with neurologic and psychiatric disorders, including schizophrenia, alzheimer's disease and attention deficit hyperactivity disorder. the mechanism of action, the allosteric modulation of α7 nachr and improvement of cognitive and memory function both in relevant animal models and patients has been clearly described in recent literature. the effect of avl-3288 strongly supports the rationale for use in schizophrenia given the dose effect relationship, peaking at a low dose in rats (hed 3 mg), in rodent schizophrenia and memory models. phase i, single-center, inpatient, randomized, double-blind, placebo-controlled, dose escalating study to evaluate the safety, tolerability and pharmacokinetic profiles of single oral doses of avl-3288 in healthy subjects. subjects will be hospitalized in the university of colorado clinical research center (ctsa) for a 12 hour period after the single dose. then there will be an ambulatory 24 and 48 hour observation and washout period of 10. patients will receive an evoked potential measurement, the p50 sensory gating paradigm, and the repeatable battery for assessment of neuropsychological status.

Eligibility criteria:
inclusion criteria: * healthy volunteer exclusion criteria: * substance use. we do not accept inquiries by email.

Keywords: schizophrenia
clinical effectiveness of polymethoxy flavones solid dispersion as a dressing material for palatal grafts donor sites

Conditions: Soft Tissue Infections; Gingival Recession

Summary: free gingival grafting surgeries require palatal grafts harvesting from the patient own palates . the donor sites pain , infection and retarded healing by secondary intension are the complication .

after the preparation and characterization of the solid dispersion of hydroxylated methoxy flavones, free gingival grafting surgeries require palatal grafts harvesting from the patient own palates . the donor sites pain , infection and retarded healing by secondary intension are the complications ; the aim of the study is to assess the analgesic , anti inflammatory effects of hydroxylated methoxy flavones.

Eligibility criteria:
inclusion criteria: * insufficient zone of keratinized gingiva recession of the gingiva non smokers free from systemic disorders exclusion criteria: * smokers insufficient palatal donor sits un realistic expectations
computed tomography scan versus color duplex ultrasound for surveillance of endovascular repair of abdominal aortic aneurysm. a prospective multicenter study

Conditions: Endovascular Repair of Abdominal Aortic Aneurysm

Summary: cumulative radiation dose, cost, contrast induced nephrotoxicity and increased demand for computed tomography aortography (cta) suggest that duplex ultrasonoraphy (du) may be an alternative to cta-based surveillance. the investigators compared cta with du during endovascular aneurysm repair (evar) follow-up. patients undergoing evar have radiological follow-up data entered in a prospectively multicenter database. the gold standard test for endoleak detection was cta. du interpretation was performed independently of cta and vice versa.


Eligibility criteria:
inclusion criteria: * patients who were followed after evar, whatever the trademark and the model of the stentgraft (bi-iliac or mono-iliac) * age \> 18 years old * patient with social insurance * signature of informed consent exclusion criteria: * patients who underwent evar with a fenestrated or branched stentgraft * obese patients (bmi \> 30) * patients with severe renal insufficiency (creatinine clearance \< 30 ml/mn) * patients who can't practice both an ct scan with iode injection and duplex ultrasound test over a period of one month
percutaneous versus open plate fixation of diaphyseal clavicle fractures

Conditions: Clavicle Fracture

Summary: this is a prospective, level ii evidence comparison between two cohorts. this study is designed to compare the percutaneous versus open approach for plate fixation of diaphyseal clavicle fractures. this study includes questionnaires and measurements that will collect data on incision-related numbness, union rates, overall outcomes, complication rates of the two methods, infection rates, and overall satisfaction. the surgical procedure, all radiographs and follow-up visits to a minimum of one year are the principle investigators (pi's) standard of care for this injury. measurements and questionnaires are related to the study.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * displaced (i.e., no cortical contact of fracture ends on two xray view) diaphyseal clavicle fracture * fracture pattern amenable to plate fixation * neurologic injury requiring open reduction * open clavicle fracture * clavicle nonunion (defined as an absence of radiographic bony union in the presence of neurologic, cosmetic, or functional complaints at six months duration * symptomatic malunion (defined as a healed, but shortened or angulated fracture in the presence of neurologic, cosmetic, or functional complaints) * clavicle fracture associated with a scapular of humeral fracture (floating shoulder) exclusion criteria: * a nondisplaced or minimally displaced closed, neurovascularly intact clavicle fracture * fracture of the medial or lateral end of the clavicle * pathological fracture * patient is unable to medically tolerate general anesthesia * patient is unable to provide informed consent or comply with completing questionnaires

Keywords: clavicle fractures numbness percutaneous plate fixation open plate fixation incision related numbness union rates subjective questionnaire based outcomes diaphyseal
the effectiveness of a brief motivational nursing intervention

Conditions: Behavior, Addictive

Summary: this was a two-staged study undertaken in entertainment-sector workers in spain: the first part was transversal and observational, and the second was semi-experimental. a short group-based motivational intervention session was implemented by nursing staff, and a before and after evaluation was completed. by reducing the patients' perception of their quality of life, this brief nursing intervention facilitated a favourable increase in the motivation for change among these workers and was effective in 12% of cases.

checking whether changes in the perception of the quality of life related to health, after the nursing intervention, influence these patients' motivation to change. this was a two-staged study undertaken in entertainment-sector workers in spain: the first part was transversal and observational, and the second was semi-experimental. first part undertook in 284 entertainmentsector workers, selected by non-probabilistic sampling, while second part undertook in 50 entertainment-business workers, selected by consecutive sampling from those who consumed substances. a short group-based motivational intervention session was implemented by nursing staff, and a before and after evaluation was completed. the euroqol-5d and test for the evaluation of the quality of life in addicts to psychoactive substances (tecvasp) were used. the patients' motivation to change was evaluated through the stages of change readiness and treatment eagerness scale.

Eligibility criteria:
inclusion criteria: * age between 18 and 65 years * working conditions that fulfilled the health and safety requirements * acceptance of the informed consent to participation. * drugs and alcohol users exclusion criteria: * younger than 18 or older than 65 * non drugs and alcohol users

Keywords: cannabis cocaine alcohol entertainment workers nursing interventions
prospective surveillance for respiratory virus infections in children undergoing hematopoietic stem cell transplantation

Conditions: Respiratory Virus Infections

Summary: the study aims to prospectively survey the incidence of respiratory virus infections using molecular methodologies, in children undergoing hematopoietic stem cell transplantation

samples will be collected with a nasopharyngeal wash and processed for direct fluorescent antibody, culture and polymerase chain reaction (pcr)

Eligibility criteria:
inclusion criteria: * age: birth to 18 years. * patients undergoing an allogeneic hsct for any disease. * parent or guardian willing to sign informed consent. exclusion criteria: * intra nasal lesion which precludes the performance of the nasopharyngeal wash. * patients on continuous positive airway pressure (cpap) or bilevel positive airway pressure (bipap).

Keywords: hematopoietic stem cell transplant
a study of ly2940094 in participants with alcohol dependency

Conditions: Alcoholism

Summary: the main purpose of this study is to evaluate a once daily (qd) 40-milligram (mg) oral dose of ly2940094 in participants with an alcohol dependency to evaluate if ly2940094 will reduce alcohol drinking in these participants. the study will last for 8 weeks.


Eligibility criteria:
inclusion criteria: * present with alcohol dependence (ad) defined by the diagnostic and statistical manual of mental disorders, fourth edition, text revision (dsm-iv-tr 303.9) * must have 3 to 6 heavy drinking days per week as assessed by the timeline follow back (tlfb) scale at screening and baseline (heavy drinking is defined as greater than 4 drinks per day for females and greater than 5 drinks per day for males) * have a body mass index (bmi) between 18 and 35 kilograms per square meter (kg/m\^2) exclusion criteria: * have had prior seizures or other condition that would place the participant at increased risk of seizures, and participants taking anticonvulsants for seizure control * have any other clinically significant medical condition or circumstance prior to randomization that, in the opinion of the investigator, could affect participant safety * meet diagnostic and statistical manual of mental disorders, fourth edition, (dsm-iv) axis i criteria for a lifetime diagnosis of schizophrenia, schizoaffective disorder, bipolar i disorder, or other psychoses
"clinical characteristics, comorbidities and outcome of critically sick patients with covid-19

Conditions: COVID-19 Pneumonia

Summary: covid-19, caused by severe acute respiratory syndrome corona virus 2 (sars-cov-2), is a multisystem disease which primarily involves the respiratory tract. the first case of covid-19 was identified in late 2019 in the province of wuhan, china which was followed by the rapid spread of the disease globally, becoming a present-day pandemic. objectives: the aim of this study was to describe the clinical characteristics, comorbidities and outcome of the critically sick patients with covid-19 pneumonia admitted in icu of a tertiary care hospital in lahore.

objectives: the aim of this study was to describe the clinical characteristics, comorbidities and outcome of the critically sick patients with covid-19 pneumonia admitted in icu of a tertiary care hospital in lahore. material \& methods: study design: retrospective study. study settings: study was conducted in fatima memorial hospital, lahore. study duration: study was conducted on covid-19 patients who were admitted from march 2021 to august 2021.

Eligibility criteria:
inclusion criteria: * critically sick patients with covid-19 pneumonia * all admitted icu patients with a diagnosis of covid-19 pneumonia * patients having positive reverse transcriptase pcr for covid-19 * patients with high-resolution computed tomography (hrct) chest findings suggestive of covid-related lung injury * all patients above 16 years of age with both genders( males and females) exclusion criteria: * all patients with pcr negative with mild symptoms * patients with no signs of covid-19 pneumonia on hrct chest

Keywords: comorbidities outcomes covid-19
breast cancer outreach among primary care patients

Conditions: Breast Cancer

Summary: this project aims to evaluate different approaches to increase breast cancer screening among primary care patients at penn medicine through a centralized screening outreach program. in a pragmatic trial, the investigators will evaluate different approaches to increase completion of screening among eligible patients, including ordering mammograms in bulk prior to outreach, sending personalized text reminders, and endorsing of the communication by the primary care provider.

while mammograms are recommended by guidelines for early detection of breast cancer, mammogram rates are significantly lower now than they were prior to the initial covid-19 pandemic surge in early 2020. in this project, the investigators will evaluate different ways of reaching out to eligible patients to encourage them to participate in breast cancer screening. through letters, texting, and the electronic health record portal (mypennmedicine (mpm)), the investigators will compare mammogram bulk orders, text messaging, and primary care provider endorsement to traditional outreach messaging with the goal of increasing breast cancer screening uptake.

Eligibility criteria:
inclusion criteria: 1. women ages 40-74 2. followed by primary care with a penn medicine pcp listed and at least one visit in the last 2 years 3. health maintenance due (default biannual screening starting at age 50 or edit modifier based on input by clinician) exclusion criteria: 1. currently scheduled for a mammogram 2. history of bilateral mastectomy

Keywords: mammography preventive screening population health
long-term paired associative stimulation as a treatment for incomplete spinal cord injury of non-traumatic origin

Conditions: Spinal Cord Diseases; Spinal Cord Injuries

Summary: the investigators have recently shown in incomplete sci patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles (1). in this study, the investigators will administer long-term paired associative stimulation to patients with incomplete sci of non-traumatic origin.


Eligibility criteria:
inclusion criteria: * incomplete sci of non-traumatic origin exclusion criteria: * epilepsy * metal inclusion in the head area * pacemaker * hearing device * high intracranial pressure
a study of tocilizumab with or without methotrexate in patients with rheumatoid arthritis.

Conditions: Rheumatoid Arthritis

Summary: this open-label, single-arm, non-randomized study will evaluate the adherence and persistence to tocilizumab therapy in patients with moderate to severe active rheumatoid arthritis, who have an inadequate clinical response to non-biologic dmards. patients will receive tocilizumab 8 mg/kg as intravenous infusion once every 4 weeks in combination with methotrexate or in case of intolerance to methotrexate as monotherapy. the anticipated time of study treatment is 6 months. the target sample size is 20-50 patients.


Eligibility criteria:
inclusion criteria: * adult patients \>/= 18 years of age * moderate to severe active rheumatoid arthritis * inadequate response, or intolerance to previous therapy with one or more traditional dmards * das \>3.6 * pneumology examination (including chest x-ray and quantiferon) exclusion criteria: * \< 18 years of age * active infection * active tuberculosis * uncontrolled hyperlipoproteinaemia * demyelinating disorders * concomitant anti-tnf drugs * history of intestinal ulceration and diverticulitis
pembrolizumab alone and in combination with acalabrutinib (acp-196) in subjects with advanced non-small cell lung cancer

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: pembrolizumab alone and in combination with acalabrutinib in subjects with advanced non-small cell lung cancer.


Eligibility criteria:
inclusion criteria: * men and women ≥ 18 years of age * ecog performance status of 0 or 1 * histologically confirmed recurrent or metastatic nsclc (adenocarcinoma, large cell, squamous cell, or not otherwise specified) that has either progressed during or after platinum-based chemotherapy * received at least 1 platinum-based chemotherapy regimen. note: subjects with egfr mutations or alk translocations are required to have received prior therapy with appropriate tki; prior platinum-based chemotherapy is not required for this specific patient population exclusion criteria: * prior malignancy (other than lung cancer), except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or other cancer from which the subject has been disease free for ≥ 2 years or which will not limit survival to \< 2 years * known central nervous system metastases and/or carcinomatous meningitis * significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias, congestive heart failure, or myocardial infarction within 6 months of screening * malabsorption syndrome, disease significantly affecting gastrointestinal function, or resection of the stomach or small bowel, symptomatic inflammatory bowel disease, partial or complete bowel obstruction, or gastric restrictions and bariatric surgery, such as gastric bypass * breastfeeding or pregnant
analysis of intraoperative bleeding characteristics in laparoscopic pancreaticoduodenectomy

Conditions: Laparoscopic Pancreaticoduodenectomy

Summary: in this study, we analyze the common bleeding characteristics in laparoscopic pancreaticoduodenectomy by reviewing and annotating bleeding information from previous surgical videos as well as surgical operation osats technique scores. from there, we reflect on the correlation between surgical operating technique and intraoperative bleeding, as well as on the correlation between intraoperative bleeding and short-term postoperative outcomes.


Eligibility criteria:
inclusion criteria: * the surgical video is complete including the resection and reconstruction phases exclusion criteria: * the surgical video is not complete * the cases combined with resection and reconstruction of mesentericoportal vein

Keywords: laparoscopic pancreaticoduodenectomy intraoperative bleeding osats scores short-time outcomes