Kornimate/medical-research-clean huggingface dataset:
comapre effects of proprioceptive training and core instability strength training in knee osteoarthritis patients

Conditions: Knee Osteoarthritis

Summary: this study aims to determine the influence of core instability exercises in comparison to proprioceptive training in relieving pain, improving balance and physical function in general population of knee osteoarthritis. the objective is to achieve beneficial results of interventions which can be used in betterment of treatment plan.

a randomized control trial will be held at safi hospital faisalabad after the approval of the synopsis. the study will be double blinded clinical trial. simple lottery method will be practiced to allocate subjects into two groups. subjects are selected according to there explained inclusion exclusion criteria. the two groups are differentiated as control group and experimental group. both the groups will be given the baseline intervention including tens and infrared. along with baseline treatment control group will be given proprioceptive training and experimental group will be given core instability exercises. the evaluation is done before the research begin, after 6 weeks, after 12th week and follow up on 16th week at the end of therapy. the outcomes will be assessed through visual analog scale, western ontario and mcmaster universities arthritis index and fullerton advanced balance scale. the data will be recorded pre and post treatment and compared after 12th week. informed consent should be signed by each patient and analysis is done by statistical package of social sciences version 21.

Eligibility criteria:
inclusion criteria: * knee osteoarthritis disease * kellgren lawrence stage 1 to stage 4 * unilateral or bilateral knee osteoarthritis * patient who are willing to participate exclusion criteria: * history of any neurological condition e.g. parkinson or vertigo. * history of any past surgical procedure related to lower extremity. * history of any chronic disease (hepatic, cardiac or renal diseases) which can affect the exercise training. * history of severe orthopedic issues like fractures which may interfere in treatment sessions.

Keywords: proprioceptive training core instability strength training knee osteoarthritis randomized control trial balance physical functions
covid-19 convalescent plasma for mechanically ventilated population

Conditions: Covid-19

Summary: the purpose of this study is to see if this plasma can be safely used in humans with covid-19 and to see if it can improve patients' health when they are sick with covid-19.

this open-label, single arm, phase 1 trial will assess the safety and efficacy of convalescent plasma in severely ill, mechanically ventilated participants with pneumonia due to covid-19. this study will enroll adults 18 years old and older, including pregnant women. a total of 50 eligible participants will receive 2 units of convalescent plasma collected from abo-compatible donors who have recovered from covid-19. participants will receive convalescent plasma on study day 1 in addition to standard of care. participants will be assessed daily while hospitalized and then on study days 15, 22, 29, and 60. all participants will undergo a series of safety, efficacy, and laboratory assessments. blood samples will be collected on days 1 (prior to plasma administration), 3, 5, 8, 11, 15, 29, and 60. oropharyngeal or endotracheal samples will be collected on days 1 (prior to plasma administration), 3, 5, 8, 11, and 15.

Eligibility criteria:
inclusion criteria: 1. adult ≥18 years of age 2. laboratory-confirmed sars-cov-2 infection as determined by pcr or other authorized or approved assay in any specimen collected within 72 hours prior to enrollment. note - an exception must be requested to the sponsor if≥72 hours since positive test. 3. hospitalized, on invasive mechanical ventilation or ecmo, consistent with a clinical status assessment 8-point ordinal scale severity score of 7. 4. documentation of pneumonia with radiographic evidence of infiltrates by imaging (e.g., chest x-ray or ct scan). 5. patient or proxy is willing and able to provide written informed consent and comply with all protocol requirements. exclusion criteria: 1. contraindication to transfusion (e.g., severe volume overload, history of severe allergic reaction to blood products), as judged by the investigator. 2. clinical suspicion that the etiology of acute illness (acute decompensation) is primarily due to a condition other than covid-19 3. receipt of other investigational therapy as a part of another clinical trial. a. note: investigational therapies used as part of clinical care, (eg, remdesivir, hydroxychloroquine) are permissible.
comparison of antiplatelet effect of ticagrelor vs tirofiban in patients with non-st elevation acute coronary syndrome

Conditions: Non-ST Segment Elevation Acute Coronary Syndrome

Summary: this is a single-center, open-label prospective randomized pharmacodynamic investigation of two anti platelet regimens in patients who are planned to undergo pci for non-st segment elevation acute coronary syndrome(nste-acs) for 24 hours 1. ticagrelor : loading dose(180mg) followed by maintenance dose(90mg bid) 2. tirofiban : 0.4ug/kg/min for 30min followed by 0.1ug/kg/min * both agents will be given on top of aspirin

in combination with aspirin, p2y12 receptor antagonist or glycoprotein iib/iiia inhibitor(gpi) is now a recommended drug as the standard dual antiplatelet regimen in patients with acute coronary syndrome(1). ticagrelor is a newly developed oral p2y12 receptor inhibitor. it shows faster, greater and more consistent platelet inhibition as compared with previous p2y12 receptor antagonist clopidogrel(2) and it also shows better clinical outcome and similar risk for bleeding as compared with clopidogrel(3).interestingly, pharmacodynamic data of some studies showed excellent effect of ticagrelor in terms of inhibiting platelet activation apparently as high as that of gpi(2,4). primary hypothesis: ticagrelor have a comparable efficacy in platelet inhibition to gpi in patients with non-st segment elevation acute coronary syndrome. statistical design : non-inferiority test

Eligibility criteria:
inclusion criteria: * patients with recent or current ischemic symptoms at the time of randomization will be eligible if 2 of the following criteria are met: st-t change indicating ischemia; a positive test of biomarker indication myocardial necrosis; or one of several risk factors(age ≥60 years * previous myocardial infarction or coronary artery bypass grafting \[cabg\] * coronary artery disease with stenosis of ≥50% in at least two vessels * previous ischemic stroke, transient ischemic attack, carotid stenosis of at least 50%, or cerebral revascularization * diabetes mellitus * peripheral arterial disease; or chronic renal dysfunction, defined as a creatinine clearance of \<60 ml per minute per 1.73 m2 of body surface area) exclusion criteria: 1. administration of fibrinolytic or any gp iib/iiia inhibitors for the treatment of current ami 2. major surgery or trauma within 30 days 3. active bleeding 4. previous stroke in the last six months 5. oral anticoagulant therapy 6. pre-existing thrombocytopenia 7. vasculitis 8. hypertensive retinopathy 9. severe hepatic failure 10. severe renal failure requiring hemodialysis 11. documented allergy/intolerance or contraindication to tirofiban or p2y12 inhibitor 12. uncontrolled hypertension (systolic or diastolic arterial pressure \>180 mmhg or 120, respectively, despite medical therapy) 13. limited life expectancy, e.g. neoplasms, others 14. inability to obtain informed consent

Keywords: ticagrelor tirofiban glycoprotein iia/iiia inhibitors p2y12 blockers acute coronary syndrome
hydrosorb® versus control in the management of radio-induced skin toxicity: multicentre controlled phase iii randomized trial

Conditions: Breast Cancer; Radiation Dermatitis

Summary: the primary objective consisted of avoiding deterioration and/or restoring the integrity of the skin of patients treated by radiotherapy, right from the first signs of grade 1 or 2 radiation dermatitis.


Eligibility criteria:
inclusion criteria: * women treated by normo fractionated radiotherapy for breast cancer * presenting grade 1 or 2 radiation dermatitis during the treatment and who provided their written informed consent were included in the study. exclusion criteria: * were male patients * radiation dermatitis already treated or caused by another treatment * subjects deprived of their freedom or under guardianship * subjects in whom medical follow-up was impossible * a cancer wound or skin flap on the irradiated zone * a history of allergic skin reaction * concomitant chemotherapy or concomitant bevacizumab therapy and bilateral irradiation.
validity of 1bpm for diagnosis of hypertension

Conditions: Hypertension

Summary: blood pressure measurement methods and conditions are determinants of hypertension diagnosis. the classical methods such as office blood pressure measurement (obpm) and home blood pressure monitoring (hbpm) have significant limitations. a recent british guideline recommends systematic 24-hour ambulatory blood pressure monitoring (abpm). however, these devices are not available at all health centers and they can only be used by one patient per day. the aim this study is to validate a new method, 1-hour blood pressure monitoring (1bpm), to diagnose the hypertension. participants with suspected hypertension will be recruited from a population of patients seen at three primary health centers in an urban area. according to the sample size estimation, a minimum sample size of 214 participants would be needed for the study. four diagnostic tests will be performed: obpm at three visits, hbpm, ampm and 1bpm. the test order for the 24-hour monitoring, and 1-hour monitoring, will be set randomly. daytime records of abpm will be compared to all other monitoring methods using the correlation coefficients and bland altman plots. the kappa index will be used to calculate degree of agreement. the sensitivity and specificity of the methods will also be calculated.


Eligibility criteria:
inclusion criteria: * age \> 18 years * to visit routinely in the health centres where the study is carried out exclusion criteria: * severe physical or cognitive limitations * atrial fibrillation or other heart rhythm disorders that could interfere with readings * arm circumference \> 42cm * arm with arteriovenous fistula * mental disorders * intolerance to the method of measurement * hospitalization during the study period

Keywords: hypertension blood pressure monitoring
efficacy of a quadruple immunosuppressor regimen with mtor inhibitors in sensitized kidney transplant patients

Conditions: Disorder Related to Renal Transplantation

Summary: in this study, sensitized renal transplant recipients, who present an increased risk of acute rejection, will be evaluated for the benefit of quadruple immunosuppression, adding sirolimus to the traditional scheme with tacrolimus, mycophenolate, and prednisone.


Eligibility criteria:
inclusion criteria: * sensitezed renal transplant recipients with reactivity panel of antibodies (pra) greater than 30% who agree and sign the consent form. exclusion criteria: * obese patients (body mass index above 35 m2); * history of gesf or membranoproliferative glomerulonephritis (mpgn) as primary cause of renal failure; * proteinuria (protein/creatinine ratio) greater than 0.5 mg/dl at the time of initiation of sirolimus; * triglyceride levels greater than 300 mg/dl at enrollment; * active infection by hepatitis b virus, hepatitis c virus or hiv; * cmv nonreactive igg sorology at the time of transplantation.

Keywords: kidney transplantation, sensitized, immunosuppression
assessment of cytokine values in serum and by rt-pcr in hiv-1 individuals with and without haart

Conditions: HIV Infections

Summary: a cross-sectional study was performed on hiv-1 infected individuals with or without antiretroviral treatment. 73 hiv-1 infected individuals were divided into three groups: g1= 15 infected individuals with or without aids who never received arv; g2= 27 patients on haart, and plasma hiv-1 rna viral load (vl) equal or greater than 50 copies/ml and g3= 31 patients on haart with undetectable vl for at least the past 6 months and a fourth group g4= 20 individuals chosen between blood donors without any disease sign and with negative hiv serum tests (control group). serum cytokine levels pg/ml (elisa) and specific mrna expression by rt-pcr were performed on all four groups for tnf-a, il-2, inf-g, il-4 and il-10. all patients were submitted to vl determination and cd4+ and cd8+t lymphocyte counts. results analysis showed a significant comparison between groups for both methods and association between them (\>80% - r2\>0.80) with only one exception, in the individuals of control group, for il-2 by elisa determination. the cytokine profile for both methods and three patient groups was mature th-0. the behavior of il-2 and inf-g must be emphasized with the consequent expression on dominant th profile. both methods showed low il-2 and elevated mean inf-g values in the three patient groups.

a cross-sectional study was performed on hiv-1 infected individuals with or without antiretroviral treatment (arv) at the aids day-hospital, botucatu school of medicine, unesp. between august 2004 and october 2005, 73 hiv-1 infected individuals were divided into three groups: g1= 15 infected individuals with or without aids who never received arv; g2= 27 patients on haart, and plasma hiv-1 rna viral load (vl) equal or greater than 50 copies/ml and g3= 31 patients on haart with undetectable vl for at least the past 6 months and a fourth group g4= 20 individuals chosen between blood donors without any disease sign and with negative hiv serum tests (control group). serum cytokine levels pg/ml (elisa) and specific mrna expression by rt-pcr were performed on all four groups for tnf-a, il-2, inf-g, il-4 and il-10. all patients were submitted to vl determination and cd4+ and cd8+t lymphocyte counts. results analysis showed a significant comparison between groups for both methods and association between them (\>80% - r2\>0.80) with only one exception, in the individuals of control group, for il-2 by elisa determination. the cytokine profile for both methods and three patient groups was mature th-0. the behavior of il-2 and inf-g must be emphasized with the consequent expression on dominant th profile. both methods showed low il-2 and elevated mean inf-g values in the three patient groups. several authors have recently drawn attention to the substantial apoptosis of infected and non infected cd4+t cells, mainly during primary infection, persisting only in those with inf-g phenotype producer and not il-2.

Eligibility criteria:
inclusion criteria: * hiv infection exclusion criteria: * no hiv infection
analgesic effect of acupuncture for patients with rib fractures

Conditions: Rib Fractures; Acute Pain; Analgesia

Summary: traumatic rib fractures are common, resulting from significant forces impacting on the chest, and are associated with significant morbidity and mortality. acute pain management in inpatients with traumatic rib fractures has been highly emphasized by practitioners. inappropriate analgesia may cause respiratory complications, including pneumonia, atelectasis, acute respiratory distress syndrome, and prolonged hospital stay. these may be prevented or reduced by good analgesic therapy. this study is aimed to investigate the analgesic effect of acupuncture on traumatic rib fractures.

this open-label, randomized controlled trial will involve 150 patients who have traumatic rib fractures. subjects are randomly assigned to acupuncture group, laser acupuncture group or sham laser acupuncture group with a 1:1:1 ratio. the intervention will be performed on the consecutive three day after allocation. bilateral li4 (hegu), sj6 (zhigou), st36 (zusanli) and gb34 (yanglingquan) are used for each group. the traditional acupuncture group will be performed by inserting needles to a depth of 15-35 mm and last for 15 min. the laser acupuncture will be performed with the gallium aluminum arsenide laserpen, which delivered 0.375 j of energy at each of the acupoints. subjects in the control group underwent sham laser acupuncture treatment without any laser output. the acupuncture points, application duration, and total number of treatments were similar to those in the laser acupuncture group.

Eligibility criteria:
inclusion criteria * chest trauma * presence of one or more, unilateral or bilateral rib fractures diagnosed with chest x-ray * maximal rib pain score of more than 5 obtained using the numerical rating scale (nrs: 0-10) * ability to describe the sites of pain and evaluate the pain intensity accurately exclusion criteria: * unable to describe the sites of pain and evaluate the pain intensity accurately * there are open wounds on the sites of acupuncture points * severe multiple trauma or any poorly controlled diseases such as atelectasis, pneumonia, or other infectious diseases, immune system dysfunction, bleeding tendency, psychiatric disorders, and skin problems * receive surgical management of rib fractures

Keywords: traumatic rib fractures acupuncture analgesia
reducing influenza among university students, university of california at berkeley

Conditions: Influenza-like Illness; Influenza

Summary: we will be testing the hypothesis whether online education for uc berkeley students on respiratory hygiene, cough etiquette, hand hygiene/awareness, as well as face mask use (while ill) will reduce the acquisition and transmission of influenza-like illness. the study will be conducted during the flu seasons 2006-7 and 2007-8.


Eligibility criteria:
inclusion criteria: * registered students * attending uc berkeley at least half-time during the study period exclusion criteria: * enrolled but studying remotely or abroad for all or part of the study period * persons less than 17 years of age
plain magnetic resonance (mr) in the assessment of patients with acute abdomen

Conditions: Acute Abdomen

Summary: at present, ct is the gold standard in the assessment of patients with acute abdomen. yet, one ct of the abdomen exposes patients to a radiation dose equivalent to several years of background radiation. mr can be expected to yield the same information without ionizing radiation, but tends to be more time consuming. in this study, patients with nontraumatic acute abdominal pain referred to ct of the abdomen by the department of surgery will also have performed an additional mr scan covering the entire abdomen with few fast imaging sequences in approximately 15min. ct is the diagnostic test. the mr scan is only used for scientific purposes. it will be evaluated by a radiologist blinded for the results of the ct scan. fourteen days after admission, a final diagnosis is established based on clinical, peroperative, pathological and lab. findings. the performance of ct and mr will then be compared. the investigators hypothesize that mr can provide a diagnostic accuracy comparable to ct.


Eligibility criteria:
inclusion criteria: * signed informed consent form * age \> 18 years old * nontraumatic acute abdomen * weight \< 120kg * can keep apnoea for 15s * surgeon in charge considers patient fit for participation in study exclusion criteria: * contraindications of mri * suspicion of acute vascular disease * severe cardial or pulmonal insufficiency * pregnancy * untreated psychiatric illness

Keywords: acute abdomen ct mri fast imaging
between the belly and the brain: distorted gut-brain crosstalk in early-life adversity

Conditions: Early Life Adversity; Microbiome, Human; Anxiety Symptoms; Depressive Symptoms; Posttraumatic Stress Symptoms

Summary: the goal of this observational study is to learn about the effects of early-life adversity (ela) on the composition of children's microbiome and on their psychosocial functioning. the main questions it aims to answer are: * do children who have experienced ela have lower gut microbial diversity and/or an altered gut microbial composition? * do these microbiome alterations correlate with adverse neurodevelopmental outcomes, including increased levels of stress, social and/or affective problems?


Eligibility criteria:
inclusion criteria: * primary school-aged children (6 to 13 years of age) who have experienced at least one early-life traumatic event, based on the childhood trust events survey (ctes) questionnaire * the child and at least one of his/her parents (or guardian) speak dutch sufficiently well to complete all of the questionnaires and the semi-structured child psychiatric interview (scid-5-junior) exclusion criteria: * any chronic disorders or diseases known to affect the gut micobiome * inablity to complete questionnaires and/or semi-structured interview because of linguistic and/or cognitive barrier * congenital or acquired immunodeficiencies * use of medication(s) that affect gastrointestinal function (e.g., antibiotics) within the last 6 weeks, or laxatives within the last 4 weeks, or probiotic or prebiotic supplements within the last 4 weeks * current involvement in another clinical or food study

Keywords: early life adversity gut microbiome anxiety symptoms depressive symptoms posttraumatic stress symptoms
effects of adding chickpeas to the american diet (long term study)

Conditions: Inflammation

Summary: this prospective study will assess the effects of adding legumes, especially chick peas, to the diet of healthy adults on the commensal bacteria from feces of human subjects and resulting self-reported gi symptoms as well as markers of immune function.

long-term observational study: subjects enrolled will participate in an observational setting for three months. during this time period, individuals will be encouraged, to maintain increased legume intake and explore new recipes that allow them to maintain a diverse menu of legume based foods. fecal samples for microbiota analysis will be collected every month. participants will record a weekly online questionnaire about legume intake and gi health as well as other health status updates. while participants will be encouraged to maintain regular intake of chickpeas throughout the long-term study, consumption of other legumes will be encouraged.

Eligibility criteria:
inclusion criteria: * good health * no systemic antibiotics during the preceding two months * no medication suppressing immune function * willingness to provide basic demographic as well as medical history data exclusion criteria: * gastric ulcers * inflammatory bowel disease (ibd) or irritable bowel syndrome (ibs) * chronic constipation/diarrhea * body mass index (bmi) \> 30 * dietary restrictions that prevent legume intake * currently on any medication that can affect gi transit time * consumption of \>3 servings/week of chickpeas or \>6 servings/week of legumes before study begins

Keywords: gut microbiota
doppler ultrasonography evaluation of tibial fracture site vascularity

Conditions: Tibial Fracture

Summary: the purpose of this study is to evaluate the blood supply to patients that are suffering from fracture in the tibia by ultrasound doppler.


Eligibility criteria:
inclusion criteria: * above 16 years old exclusion criteria: * pregnancy
dual-task training during curved walking in stroke patients

Conditions: Stroke Rehabilitation

Summary: the purpose of this study is to explore the effects of curved walking training under dual-task conditions on the cognitive function and walking ability of stroke patients.


Eligibility criteria:
inclusion criteria: 1. first-time unilateral stroke 2. age between 40 and 80 years 3. able to walk 10 meters continuously with or without the use of assistive devices 4. capable of following instructions and performing simple arithmetic 5. brunnstrom stage 3 or higher exclusion criteria: 1. other neurological disease or unstable medical conditions 2. visual field defect 3. mini-mental state examination (mmse) \<24 points 4. pusher syndrome 5. half-sided neglect 6. expressive aphasia 7. poorly controlled hypertension or cardiovascular disease