Kornimate/medical-research-clean huggingface dataset:
wearable flexible sensors for spinal motion monitoring

Conditions: Spine Disease

Summary: with the deepening of societal aging, degenerative spinal diseases have become increasingly prevalent in china and are one of the leading causes of disability among middle-aged and elderly populations. current musculoskeletal assessment methods primarily focus on imaging rather than functional evaluation, and emphasize static over dynamic analysis, failing to capture the daily functional state of the musculoskeletal system. this limitation hinders a deeper understanding of functional patterns and their role in the progression of degenerative spinal diseases. therefore, there is an urgent need to develop precise and dynamic functional assessment methods that overcome the constraints of time and space in measurement. this project adopts a dynamic perspective of the musculoskeletal system, developing a wearable monitoring approach based on flexible sensors to assess limb and spinal motion. the method will be validated against traditional imaging techniques such as x-ray and ultrasound, laying the foundation for investigating the pathogenesis of degenerative spinal diseases. this research aligns with china's strategic initiatives and practical needs in addressing the challenges of an aging population.


Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of spinal cord injury 2. clinical diagnosis of cervical spondylotic myelopathy with impaired hand function 3. clinical diagnosis of kyphosis 4. clinical diagnosis of spinal imbalance 5. clinical diagnosis of scoliosis patients 6. clinical diagnosis of lumbar spondylolisthesis patients exclusion criteria: 1. obesity (bmi\>30) 2. inability to complete functional assessments due to physical condition or other reasons; 3. comorbid neuromuscular disorders

Keywords: flexible sensor spine disease
prediction frozen shoulder validation

Conditions: Frozen Shoulder

Summary: background: few studies have examined the predictors of the clinical course of subjects with frozen shoulder syndrome or explained the persistence of symptoms after appropriate therapy. altered shoulder kinematics may predispose subjects to subacromial impingement, rotator cuff tendonitis, altered shoulder joint forces, and possible degenerative changes. subsequently, a more difficult and chronic course of frozen shoulder syndrome may develop. objective: the purposes of this study are: (1) to develop a prediction method for determining altered shoulder kinematics and associated muscular activities which are associated with the chronicity of frozen shoulder dysfunction, and (2) to validate this prediction method and analyze the impact of the method on clinical behavior. design: for the first year, a prospective study will be conducted to develop a prediction method that will identify impaired shoulder kinematics associated with the degree of symptom-related functional disability in patients with frozen shoulder syndrome. for the second and third years, validation of the proposed prediction method will determine whether altered shoulder kinematics and associated muscular activities subject to intervention meet the prediction criteria and demonstrate improvement in their follow-up, which will be shown to improve decision making in clinical practice.


Eligibility criteria:
inclusion criteria: * 50% loss of passive movement of the shoulder joint relative to the nonaffected side, in 1 or more of 3 movement directions (i.e., forward flexion, abduction in the frontal plane, or external rotation in 0° of abduction); * 13-15 and duration of complaints of at least 3 months. exclusion criteria: * a history of stroke with residual upper-extremity involvement, * diabetes mellitus, * rheumatoid arthritis, * rotator cuff tear, * surgical stabilization of the shoulder, * osteoporosis, or * malignancies in the shoulder region. * subjects who had pain or disorders of the cervical spine, elbow, wrist, or hand, or who had pain radiating from the shoulder to the arm, were also excluded.
thoracic paravertebral block : effect on acute pain and chronic pain of hepatectomy with right j-shape subcostal incision

Conditions: Hepatectomy; Analgesia; Nerve Block

Summary: this prospective, randomized study,control study aims to compare the analgesic effect,opioids consumption,quality of recovery,length of hospital stay and incidence of chronic pain,et al. single-injection tpvb +continuous(pulsatile infusion) tpvb and intravenous patient-controlled analgesia (ipca) alone in patients undergoing hepatectomy with right j-shape subcostal incision.


Eligibility criteria:
inclusion criteria: * age 18-70 yrs * american society of anesthesiologists physical statusⅰ-ⅲ * undergo hepatectomy with j-shape subcostal incision * informed consent exclusion criteria: * a known allergy to the drugs being used * coagulopathy, on anticoagulants * analgesics intake, history of substance abuse * participating in the investigation of another experimental agent * inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)
effectiveness of dry cold application on pain and bruise at the subcutaneous injection site among patients admitted in icu

Conditions: Pain; Bruise

Summary: the study evaluate the effectiveness of dry cold application on pain intensity and bruise at the subcutaneous injection site among patients admitted in medical i.c.u. purposive sampling technique was used to select 60 hospitalized patients (30 in experimental and 30 in comparison group). dry cold was applied to the subcutaneous injection site using ice bag filled with crushed ice with half table spoon of salt for 20 minutes after the administration of injection and no intervention was given in comparison group.

setting was randomized by lottery method. subjects were selected by purposive sampling technique. self-introduction was given to the subjects. rapport was developed with subjects. nature and purpose of the study was explained to the subjects. subjects were assured about the confidentiality of their responses and informed written consent was taken prior to the data collection. subjects in the experimental and comparison group were administered low molecular weight heparin injection subcutaneously by the researcher itself. after administration of subcutaneous injection of low molecular weight heparin, dry cold application using ice bag (crushed ice was filled in ice bag with ½ table spoon of salt and then covered by clean linen to prevent moisture) was placed over the injection site for about 20 minutes in experimental group and no intervention was given in comparison group. pain was assessed using numerical pain rating scale after 20 minutes of subcutaneous injection in both the groups (experimental and comparison). at 12 hr, 48 hr and 72 hr after the subcutaneous injection, bruise was assessed in both the groups using bruise assessment scale.

Eligibility criteria:
inclusion criteria: admitted in medical intensive care unit between the age group of 18-75 yrs willing for participation in the study receiving subcutaneous injection exclusion criteria: having altered sensorium suffering from any skin disease at injection site

Keywords: dry cold application pain bruise subcutaneous injection
investigation on the middle size molecule elimination characteristics of the fxcordiax 100 in relation to the fx 100 and the polyflux 210 h dialyser

Conditions: Renal Failure Chronic Requiring Hemodialysis

Summary: the purpose of the study is to compare clearance and removal rates of phosphate, ß2-microglobulin (ß2-m) and leptin and albumin loss with different dialyser membranes during post-dilution online hemodiafiltration.


Eligibility criteria:
inclusion criteria: * hemodialysis patients 18 years and older * treated by post dilution on-line hemodiafiltration (hdf) for at least one month * who reached a dialysis dose (kt/v) of at least 1.2 at each of the last two monthly checks * who are on a stable anticoagulation and anemia management * whose hemoglobin is between 10.5 and 13.0 g/dl * who are clinically stable based on judgment of nephrologist * who are on a regular thrice weekly hdf schedule, e.g. monday-wednesday-friday or tuesday-thursday-saturday, * who have a good vascular access (fistula or graft) which enables easy insertion of the needles and suitable effective blood flow (\> 300 ml/min) * who are able to understand the nature and requirements of the clinical investigation and who have given written informed consent exclusion criteria: patients * with active hepatitis b, hepatitis c or hiv infection * who are severely malnourished as judged by the principal investigator * who are known or suspected to have allergy to the trial products or related products * with a central venous catheter based vascular access * who are abusing non-legal drugs or alcohol * who have currently active malignant disease * who are female of child-bearing age without effective measures of contraception, pregnant or breastfeeding * who participate simultaneously in another clinical investigation * who have participated in othe clinical investigations during the last month * who are uncooperative
severity: quantifying the severity of generalized tonic-clonic seizures (gtcs) with connected devices

Conditions: Epilepsy, Generalized

Summary: by bringing together the fields of seizure detection and that of sudden unexpected death in epilepsy (sudep), the current project aims at delineating which set of biosensors and related biomarkers would optimally characterize the severity of gtcs and the associated risk of sudep.

the main objective is to to evaluate which of the five biosignals considered, being, electrodermal activity (eda), heart rate (hr), accelerometry (ac), arm-measurement of skin electromyography (emg), and bed sensing of body movement (bm), or any of their combinations, offers the most accurate detection and quantification of our primary indicator of gtcs-severity, i.e. postictal eeg suppression (pges).

Eligibility criteria:
inclusion criteria: * male or female aged 12 years or older, suffering from epilepsy * patient undergoing video-eeg recording * patient at risk of presenting a gtcs during video-eeg monitoring according to one of the following criteria (i) known to suffer from gtcs, or (ii) considered for antiepileptic drugs (aed) tapering during video-eeg (gtcs often occur during video-eeg as a result of aed tapering for promoting the occurrence of seizures). * patient willing to participate in the study and signed informed consent, by patient or legal representative when required. exclusion criteria: * patients aged less than 12 years old * patient not willing to participate in the study, and where informed consent from the patient or the legal representative, when required, cannot be obtained - patient considered not at risk of presenting a gtcs during video-eeg because they are not known to suffer gtcs and not candidate to aed tapering during video-eeg.
litmus imaging study

Conditions: NAFLD; NASH; NASH - Nonalcoholic Steatohepatitis; Fibrosis, Liver; Steatosis of Liver

Summary: the litmus imaging study is a prospectively recruited, observational study of patients with histologically characterised non-alcoholic fatty liver disease (nafld). it aims to evaluate the diagnostic performance of imaging biomarkers (ultrasound elastography and magnetic resonance biomarkers) against nafld histological scores in a cross-sectional analysis and the natural history of nafld in a longitudinal study.

the litmus imaging study is a non-interventional, observational study conducted in parallel to the european nafld registry (nct04442334), collecting cross-sectional and longitudinal ultrasound elastography and magnetic resonance elastography and imaging data. the litmus imaging study recruits patients with nafld who are having a clinically indicated liver biopsy and are already participating in the european nafld registry. patients in the litmus imaging study have additional imaging assessments at baseline (within 100 days of baseline liver biopsy) and 2 years after baseline (no follow-up biopsy necessary). imaging assessments include point shear wave elastography, 2d shear wave elastography, mri scans (liver multiscan, demili, diffusion weighted imaging, proton density fat fraction, t1 mapping) and mr elastography. link-anonymised magnetic resonance data are uploaded to a central online portal and analysed centrally by 4 imaging core labs provided by perspectum (liver multiscan), antaros medical (mr elastography and dwi), resoundant (vendor specific pdff) and university of seville (demili).

Eligibility criteria:
inclusion criteria: 1. recruited to the european nafld registry 2. patient had a liver biopsy less than 3 months prior to enrolment into the study or is having a liver biopsy in less than 3 months' time for the assessment of nafld. 3. participant is willing and able to give informed consent for participation in the study. exclusion criteria: 1. patients that do not speak the language in which the patient information is written will be excluded. due to the nature of the study, being able to read the information about the study or access to a relevant interpreter is a necessary criterion for participant's safety in regards to mr scanning. 2. patients judged by the investigator to be unsuitable for inclusion in the study (e.g. where the investigator feels that the participant will not be able to comply with the study procedures) 3. any contra-indication to magnetic resonance imaging (mri) (e.g. ferrous metal implants/fragments, implantable cardiac defibrillator or permanent pacemaker, metal clips following neurosurgery, pregnancy, other condition that would make mr scanning unsafe in the opinion of the scanner operator)

Keywords: liver multisscan magnetic resonance elastography magnetiic resonance imaging demili diffusion weighted imaging proton density fat fraction pdff iron corrected t1 ct1 liver stiffness mri mre diagnostic study litmus
effect of food acceptability on appetite hormones' response in normal weight vs. obese male subjects

Conditions: Eating Behavior

Summary: male subjects with specific body characteristics were recruited for the study. subjects did an acceptability test on custard and completed a screening questionnaire. around 30 subjects (15 with a normal bmi and 15 obese) continued the study. at each test day, fasting blood samples were withdrawn by a registered nurse under sterile conditions. this procedure was followed by ingestion of one of the two meals within a period of 10-15 minutes. blood samples of 5 ml were collected at fasting and after ingestion of meals. at the end, subjects were given ad lib access to cheese pizza to assess energy intake after the custard preload. blood analysis for glp-1, ghrelin, insulin and glucose levels were performed.

male subjects were recruited for the study based on the following criteria: age between 18 and 50, body mass index normal or obese, non-smokers, non-alcoholic, and do not take medications. subjects did an acceptability test on custard and completed a screening questionnaire. around 30 subjects (15 with a normal bmi and 15 obese) continued the study. subjects were randomly assigned to one of two meals. each of the two meals was ingested after a 3-day adaptation period. the meals had similar macronutrient composition and provided energy equivalent to 30% of the subjects' resting energy expenditure. at each test day, fasting blood samples were withdrawn by a registered nurse under sterile conditions. this procedure was followed by ingestion of one of the two meals within a period of 10-15 minutes. blood samples of 5 ml were collected at fasting and after ingestion of meals at 15, 30, 60, 120, 180 and 240 minutes. at the end, subjects were given ad lib access to cheese pizza to assess energy intake after the custard preload. blood analysis for glp-1, ghrelin, insulin and glucose levels were performed.

Eligibility criteria:
inclusion criteria: * gender: male * age: 18-50 years * body mass index (bmi): 18.5-24.9 kg/m2 or 30-39.9 kg/m2 * stable body weight for at least three months before the study with the absence of any form of dieting, food restriction or other abnormal eating behaviors (to minimize the effect of weight change on ghrelin and glp-1 statuses) * agreement on the acceptability levels of the two versions (high and low acceptability) of custard exclusion criteria: * smoking * substance abuse such as alcohol or drugs * medical or psychological illness * previous gastrointestinal surgery * history of weight fluctuation (weight loss of greater than 5% within the past 3 months)

Keywords: food, acceptability, appetite, hormones, ghrelin, glp-1
hypoalgesic effect of neural mobilization versus ibuprofen pharmacologic treatment

Conditions: Cervicobrachial Neuralgia

Summary: the purpose of this study is to compare the effectivity of median nerve neural mobilization and oral ibuprofen in treating patients who suffer cervicobrachial pain

median nerve neural mobilization and ibuprofen both relieve cervicobrachial pain, but this happens through different mechanisms and with a different onset of side effects. median nerve neural mobilization is a physical therapy technique that achieves pain relief through mechanical stimulation of the median nerve and the brachial plexus. the proper mechanical stimulation of the nerve and its surrounding neural tissue induces a wide variety of physiologic responses that may reduce cervicobrachial pain including the activation of descending nervous system pain modulation mechanisms, all though the entire set of underlying reasons for this pain reduction is not completely understood. among the effects caused by the neural tissue mobilization that produce pain relief are: intraneural edema reduction, changes on the intraneural nerve pressure,dispersion of pro-inflammatory substances and an increase in nerve mobility ibuprofen is a nonsteroidal anti-inflammatory drug used worldwide to control pain, fever and inflammation.oral intake of ibuprofen produces a hypoalgesic effect due to biochemical inhibition of the cox enzymes, which convert arachidonic acid to prostaglandin h2 (pgh2). pgh2, which in turn, is converted by other enzymes to several types of prostaglandins and thromboxanes (which are mediators of pain and inflammation). side effects derived from the oral intake of ibuprofen are related to its systemic action and can be severe in some patients. this fact suggests that oral ibuprofen may not be suitable to use in all types of patients suffering from cervicobrachial pain, meanwhile the median nerve neural mobilization has little to no side effects known. this reveals a point of interest in determining comparative effectiveness between this two therapeutic options in the treatment of cervicobrachial pain.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of cervicobrachial pain confirmed by magnetic resonance imaging * presence of unilateral symptoms of arm pain, paresthesia or numbness in the upper extremity during at least 3 continuous months previous to the application of treatment. * positive results in all of the following tests: spurling, distraction, and upper limb exclusion criteria: * contraindication in the use of nonsteroidal anti inflammatory drugs (nsaids) * the use of any type of treatment, therapy, procedure or drug to relieve pain * patients who are under anticonvulsant, antidepressant or psychotropic medication * vertebral instability * vertebral osteoporosis * vertebral or spine infection. * neurologic diseases of genetic, infectious or neoplastic origin * cervical stenosis myelopathy * pregnancy * kinesiophobia * endocrine disorders and menopause * history of spine surgery * intellectual disability, severe mental illness, intoxication, severe sleep deprivation, alzheimer's disease.
the role of the muscle-nervous system interface in cancer cachexia

Conditions: Cachexia; Cancer; Sarcopenia

Summary: sarcopenia is an important component of cachexia associated with cancer, and their high incidence in cancer patients emphasizes the need for a better understanding of its mechanisms, which can result in better therapeutic interventions to reverse this situation and improve the prognosis. our hypothesis is that the plasma concentration of il-6 and c-terminal agrin is directly correlated with the loss of muscle mass and development of cachexia.

the agrin is a protein that acts on neuromuscular junctions (nmjs) promoting stabilization of same, which results in the maintenance and growth of muscle fibers, but the cleavage of agrin, a process by which is formed the agrin fragment c-terminus (caf), has been linked to the development of sarcopenia, because its presence is directly linked to the reduction in the number of muscle fibers, increasing the heterogeneity of fiber size, presence of central cores and increasing the proportion of type i fibers and consequently a greater degradation of lean body mass. studies in mice show that the greatest cleavage of agrin carries on development of sarcopenia and human studies report that individuals with higher serum levels of sarcopenia caf compared to individuals without sarcopenia. therefore, aiming at the complexity of cancer associated with the cachexia and the great importance of the maintenance of lean body mass to a better prognosis in disease, is of fundamental importance to elucidate the role of caf and the factors associated with sarcopenia, the possible use of these proteins for diagnosis and the contribution that this clarification could bring in clinical therapy.

Eligibility criteria:
inclusion criteria: * cancer diagnosis exclusion criteria: * continuously use of anti-inflammatory medications; * present renal and/or liver failure, * aids, * inflammatory bowel disease or chronic inflammatory processes not related to cachexia.

Keywords: agrin fragment c-terminus (caf)