Kornimate/medical-research-clean huggingface dataset:
a controlled comparison of pulsed radiofrequency vs physical therapy on treating chronic knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: it is estimated that nearly 27 million us adults have osteoarthritis (oa) and suffer from pain . pulsed radio frequency (prf) is one method that has been successfully used in treatment of various etiologies of pain. however there are limited studies and research that prove its effectiveness in treating articular pain. the proposed study's primary aim is determining if prf is an effective treatment for chronic osteoarthritic knee pain. this study hypothesizes that prf has analgesic properties immediately after treatment and at least 3 months afterwards compared to control treatment with physical therapy. additionally this research project addresses several other objectives including: 1. provide a controlled study to determine the effectiveness of prf for intra-articular pain 2. determine how effective prf is 1 month and 3 months after treatment for articular pain. 3. further scientific evidence on the overall effectiveness of prf 4. provide evidence that prf likely has other mechanism of action besides direct nerve stimulation of inhibitory pain pathways. 5. compare the effectiveness of prf vs physical therapy in treating chronic knee osteoarthritis.


Eligibility criteria:
inclusion criteria: * age greater than 18 * radiologic evidence of kellgren-lawrence knee arthritis between levels 1-3 * satisfy the american college of rheumatology criteria for knee osteoarthritis. exclusion criteria: * failure to satisfy inclusion criteria * existence of general contraindications against percutaneous knee intervention including (e.g. infection, hemorrhagic diathesis, anticoagulated patients) * patients with pacemaker or stimulator implants * metallic hardware located in the treatment knee of choice * high clinical suspicion for alternative diagnosis other than knee osteoarthritis * va defined vulnerable populations (e.g. adults with cognitive impairments, mentally retarded, non-english speaking, severe psychiatric disorders, prisoners, terminally ill patient, employees, homeless, pregnant). * any patient that would not be able to follow up at 1 and 3 months after intervention. * any patient unwilling to receive physical therapy

Keywords: focus: pulsed radiofrequency (e02.779.468.599)
qualitative study about psychedelics using in psychiatric disorders

Conditions: Psychiatric Disorder

Summary: this study is set up to better understand the current use of psychedelics in france in the general population. the present focus on individuals who have used any type of psychedelic drug in order to suppress or alleviate a psychiatric symptom in the context of a diagnosed pathology. the data are collected during a semi-structured interview and then studied in a thematic analysis.


Eligibility criteria:
inclusion criteria: * patients diagnosed with a psychiatric disorder by a psychiatrist or general practitioner * patients used psychedelic or related substances in order to treat psychiatric symptoms * patients have given their oral non-opposition * patients affiliated to a social security scheme exclusion criteria: * patients who don't speak or understand french * patients under protection, guardianship or curators

Keywords: psychiatric disorder psychedelics
hemodynamic impact on critical care patients with lung damage secondary to covid-19

Conditions: Covid19; Hemodynamic Instability; ARDS, Human

Summary: the aim of the present work is to describe the hemodynamic effects shown in patients with ards secondary to sars-cov-2 infection


Eligibility criteria:
inclusion criteria: * patients over 18 years old. * patients that are classified as a "confirmed case" according to criteria established by the spanish ministry of health in its technical document updated on march 31, 2020. this defines a "confirmed case" as a case that meets laboratory criteria (positive pcr test for any of the sars-cov-2 genes). * patients admitted to icu. * presence of kirby index (pafi) less than or equal to 300 mm hg, with peep or cpap greater than or equal to 5 cmh2o. * need for radial artery cannulation for hemodynamic monitoring and/or repeated monitoring of blood gases at the discretion of the responsible physician. * patients who agree (or a representative of the patient if sedated) to participate in study and who provide written informed consent. exclusion criteria: * patients being treated with veno-venous or veno-arterial ecmo * patient with therapeutic restrictions due to life support * patient who presents a complication that requires surgical intervention.

Keywords: covid hemodynamic monitoring ards
morbidity related to secondary hyperparathyroidism after renal transplantation

Conditions: Secondary Hyperparathyroidism; Disorder Related to Renal Transplantation

Summary: the purpose of the study is to evaluate the long term vascular morbidity and mortality in kidney transplant recipients based on one year post transplant levels of intact parathyroid hormone.

secondary hyperparathyroidism (shpt) is a well known complication to chronic renal failure. with impaired renal function the phosphate excretion from the kidney is reduced. together with low levels of 25- and 1,25-vitamin d3 and hypocalcemia this uremic mineral milieu drives the release of parathyroid hormone (pth) and the development of shpt. pth has many functions but acts mainly to release calcium from the skeleton, to enhance calcium uptake from the intestines (by actions on vitamin d) and to lower serum phosphate by inducing phosphaturia. shpt has been shown to cause vascular morbidity and fractures in the chronic kidney disease (ckd) patient. after successful renal transplantation (rt) the mineral disturbances are mostly recovered and stabilized at one year post rt, but in recent years it has been shown that shpt persists in the major part of rt-recipients even after long term follow up. this has been associated with high risk of fractures and vascular related morbidity in the post transplant period. it has also been shown that low levels of ipth in the post-transplant period might be associated with a high risk of fractures. because of insufficient data on pth levels and associated morbidity there is no specific recommendations of target pth levels in the rt-patient. this indicates that there is need for further observational studies to describe the shpt-associated morbidity in a post transplant cohort based on stabilized levels of post transplant ipth.

Eligibility criteria:
inclusion criteria: * between 18-85 years at date of transplantation * signed informed consent or deceased at time of data collection exclusion criteria:

Keywords: secondary hyperparathyroidism renal transplantation myocardial infarction fracture graft failure
exploring the genome-wide association study of the population with clinical cure advantage in the treatment of chronic hepatitis b with long-acting interferon

Conditions: Chronic Hepatitis B

Summary: this study is a real-world case-control study conducted, with 120 chb patients who received continuous treatment with peg-ifn-α for more than 24 weeks as study subjects. among them, the clinical cure group obtained through peg-ifn-α treatment is the case group; the group that did not achieve clinical cure after peg-ifn-α treatment was used as the control group, and the case group and control group were allocated cases in a 2:1 ratio. collect blood samples from subjects as sequencing samples for candidate genes, use high-throughput sequencing technology to detect the whole genome of subjects, identify relevant genetic polymorphism that have predictive value for clinical cure of chronic hepatitis b treated with peg-ifn-α, and establish a predictive model and calculation formula between gene polymorphism and the efficacy of peg-ifn-α antiviral therapy.

this study is a real-world case-control study conducted on 120 patients with chronic hepatitis b (chb) who were continuously treated with pegylated interferon-α (peg-ifn-α) for more than 24 weeks. among them, the clinical cure group obtained through peg-ifn-α treatment is the case group; the group that did not achieve clinical cure after peg-ifn-α treatment was used as the control group, and the case group and control group were allocated cases in a 2:1 ratio. collect blood samples as candidate gene sequencing samples, use high-throughput sequencing technology to detect the whole genome of the subjects, identify relevant genetic polymorphism that have predictive value for clinical cure of chronic hepatitis b with peg-ifn-α therapy, and establish a predictive model and calculation formula between gene polymorphism and the efficacy of peg-ifn-α antiviral therapy.

Eligibility criteria:
inclusion criteria: * 18 years old ≤ age ≤ 70 years old, han ethnicity, gender not limited; * according to the "guidelines for the prevention and treatment of chronic hepatitis b (2022)", patients with hbsag and/or hbv dna positivity for more than 6 months and chronic inflammatory liver disease caused by persistent hbv infection are diagnosed with chronic hepatitis b (chb); * the patient receives subcutaneous injections of peg-ifn-α for at least 24 consecutive weeks; * patients voluntarily sign an informed consent form before the start of the study. exclusion criteria: * patients with co infection of hcv, hdv, hiv, and treponema pallidum; * patients with evidence of alcohol abuse, decompensated cirrhosis, liver tumors (liver cancer or afp\>100 ng/ml), or autoimmune diseases. * patients who become pregnant during peg-ifn - α treatment; * other situations that the patient deems unsuitable for inclusion in this trial.

Keywords: chronic hepatitis b pegylated interferon-α clinical cure gene sequencing genetic polymorphism
acute kidney injury in critically ill patients

Conditions: Acute Renal Injury

Summary: acute kidney injury (aki) in critically ill trauma patients has been shown to significantly increase mortality, length of stay, and costs, however detection has proven difficult as markers like elevated creatinine and decreased urine output may take days to manifest and are late indicators of aki. the combination of two urinary biomarkers, tissue inhibitor of metalloproteinase 2 (timp-2) and insulin-like growth factor binding protein 7 (igfbp-7), has been shown to increase within 12 hours following renal insult, allowing assessment of risk for developing acute kidney injury. therefore, the investigators plan to assess if acute kidney injury in critically ill trauma patients can be determined earlier using urinary timp-2 and igfbp-7 via the nephrocheck testing system. these markers have not been specifically evaluated in trauma patients at risk of aki.


Eligibility criteria:
inclusion criteria: * trauma patients with multiple injuries; * abdominal injuries; * crush injuries; * those who present in shock (systolic blood pressure \<90 or mean arterial pressure \<65); * require blood transfusions, vasopressors or mechanical ventilation exclusion criteria: * known pregnancy; * patients under 21 years of age; * known moderate to severe aki prior to enrollment and end stage renal disease. known moderate to severe aki prior to enrollment and end stage renal disease
evaluation of intraoperative dexmedetomidine use in patients undergoing surgical aortic valve replacement

Conditions: Systemic Inflammatory Response; Aortic Valve Stenosis

Summary: aim of this randomized prospective study is to investigate the immunomodulatory effects of dexmedetomidine on outcomes in patients with isolated aortic stenosis after surgical aortic valve replacement.

study will investigate effects of two different doses of dexmedetomidine on concentrations of tumor necrosis factor-α and interleukin-6, on inflammatory parameters (c reactive protein and procalcitonin) and inflammatory complications, renal function, postoperative delirium, anaesthetic and analgetic consumption and compare it to control group. it should provide a better understanding of dexmedetomidine effect on decrease of inflammatory response in patients undergoing cardiac surgery. short-term infusion of dexmedetomidine could reduce inflammatory postoperative complications, contribute to improvement of perioperative renal function and occurrence of postoperative delirium, supporting recovery and shortening hospital stay.

Eligibility criteria:
inclusion criteria: * isolated aortic stenosis adult patients with written consent exclusion criteria: * bmi \<30kg/m2 * 1st, 2nd and 3rd degree av block * bradycardia hr\<50/min upon arrival to operating theatre * neurological disorders (parkinson's disease, myasthenia gravis, multiple sclerosis, brain tumors in anamnesis) * recent use of psychoactive drugs * alcohol and illicit drug addiction * diabetes type i with complications * patients who develop hypotension after initiation of dexmedetomidine infusion requiring vasoconstriction therapy * patients receiving corticosteroids in perioperative period * patients with known allergy to dexmedetomidine

Keywords: dexmedetomidine
cognitive reserve on pain catastrophizing and cognitive function in geriatric patients with chronic pain

Conditions: Chronic Pain

Summary: to investigate the association between cognitive reserve, pain catastrophizing, and cognitive function in geriatric patients with chronic pain, and to explore whether cognitive reserve moderates the relationship between pain catastrophizing and cognitive function.


Eligibility criteria:
inclusion criteria: * aged 65 to 85 years * experiencing chronic pain (≥3 months) attributable to osteoarthritis or neuropathic conditions * able to read, write, and speak the language in which assessments are administered * willing and able to provide informed consent exclusion criteria: * diagnosed with a neurodegenerative disorder (e.g., alzheimer's disease, parkinson's disease) * history of significant head injury, stroke, or brain tumor * current substance abuse or dependence * severe psychiatric illness (e.g., schizophrenia, bipolar disorder) * significant sensory or motor impairments that may interfere with the ability to complete assessments
mpm medical comatryx surgical bovine collagen study

Conditions: Surgical Wound, Healed

Summary: the objective of this prospective enrollment study is to collect data confirming safety, performance and clinical benefits of the comatryx surgical collagen powder at a minimum 1-year follow-up and compare it to a historical control group who did not receive the product at the time of surgery. the primary objective is to confirm safety and clinical benefits of the product. this will be assessed by recording the rate of wound healing and incidence and frequency of wound care related complications. relationship of complications to the product should be specified.

the comatryx surgical collagen powder is a soft tissue repair product made of 100% type i bovine collagen. it is non-hydrolyzed and not cross-linked chemically. it is biocompatible, biodegradable and free of synthetics. the product does not have any specific storage requirements. the comatryx surgical collagen powder provides a physiologically favorable environment to promote healing at the wound site. when administered, the powder conforms to the wound site and forms a gelatinous occlusive barrier. along with providing 19 amino acids directly to the wound site it also occludes live nerve endings reducing pain. treating the wound with the comatryx surgical collagen powder provides the non-hydrolyzed collagen wound surface promoting autolytic debridement. the powder is effective in all phases of wound healing and can be delivered with antibiotics in areas where there may be a cavity. this product has fda 510(k) clearance for surgical wounds, full thickness wounds, traumatic wounds and skin tears.

Eligibility criteria:
inclusion criteria: * • subjects must be 18 years of age or older * subject must be willing and able to sign irb approved informed consent * subject must have a bmi of 35 or higher * surgical approach of only asi (anterior supine) * primary total hip arthroplasty * revision total hip arthroplasty exclusion criteria: * • subjects more than 85 years of age * subjects who will be or have undergone bilateral total hip replacements * subject is known to be pregnant or nursing * subject is an alcohol or drug abuser * subject has a psychiatric illness or cognitive deficit that will not allow for proper informed consent
kids 2 be & breathe: a study on the use of yoga and mindfulness in children with severe asthma (k2b2)

Conditions: Asthma

Summary: this proposed pilot study will examine the tolerability, feasibility, acceptability, and preliminary effects of a gentle yoga intervention "kids 2 be \& breathe" (k2b2; a manualized 30 minute gentle yoga and mindfulness session held one-on-one) in urban children aged 7-11 with severe asthma.

pre-intervention assessment: permission/assent from the child and consent of the parent/guardian will be obtained and initial data and measurements will be collected to ensure continued eligibility; baseline measures will be assessed. intervention: participants will engage in a one-time manualized, age appropriate, 1:1, 30-minute intervention involving gentle yoga and mindfulness techniques in a private room in the pediatric research unit at the children's hospital of richmond. the intervention will be taught by certified and experienced child yoga instructors who have been trained in the study protocol by the applicant. these yoga instructors collaborated with the interdisciplinary research team in the development of manualized age-appropriate yoga sequences. parents/guardians will be invited to observe the yoga session. intervention fidelity will be maintained through the use of a manualized intervention and the pi observing all sessions for manual consistency. the intervention will cease if the participant suffers from any asthma symptoms during the intervention, such as wheezing, coughing, retractions, accessory muscle use, chest tightness or shortness of breath, or experiences any other adverse events which precludes the his or her ability to actively participate in the intervention. post-intervention assessment: upon completion of the intervention, brief semi-structured interviews will be conducted with the child and parent/guardian separately in order to explore the acceptability of the intervention and the pi will again assess the child for any asthma symptoms or adverse events. post-intervention pulmonary function test and vital sign measurements will then be collected.

Eligibility criteria:
inclusion criteria: * on medium to high doses of steroids and/or leukotriene inhibitors * a child-asthma control test score \<21 exclusion criteria: * inability to speak english (child); inability to read/write english (parent/guardian) * child hospitalized in past two weeks for their asthma * current illness associated with oral temperature \>100.4 * pulse ox \<95% and/or any wheezing, retractions or accessory muscle use
the role of splinting in fingertip injuries

Conditions: Injury Distal to Flexor and Extensor Tendon Insertions

Summary: this study is attempting to understand whether or not splinting after a fingertip injury improves recovery.


Eligibility criteria:
inclusion criteria: * injury distal to flexor and extensor tendon insertions * crush, avulsion, amputation, or penetrating injury to the fingertip * isolated injury, within two weeks exclusion criteria: * operative fixation required * unable to participate in rehab
ultrasound vs palpation for radial artery cannulation

Conditions: Obese

Summary: the primary purpose of this study is to compare the palpation technique with ultrasound guidance for radial artery cannulation for bariatic surgery.


Eligibility criteria:
inclusion criteria: * american society of anesthesiologists 1, 2, 3 bmi ≥ 30 bariatic surgery exclusion criteria: * refusal infection or surgery history in wrist
adipose-derived mesenchymal stem cell for preventing biliary complications

Conditions: Liver Transplant; Complications; Liver Diseases

Summary: the purpose of this study is to assess the safety of autologous adipose-derived mesenchymal stem cell for use in end-stage liver disease patients undergoing the creation of a duct-to-duct anastomosis during living donor liver transplantation.


Eligibility criteria:
inclusion criteria * listed for liver transplantation * non-pediatric patients with a planned ldlt * ability to communicate with investigative staff * competence to give written informed consent * ability to comply with the entire study procedure * all sexes and genders will be eligible for the study exclusion criteria * planned deceased donor liver transplantation * uncontrolled / unresolved local or systemic infection * body mass index \> 40 * planned pancreaticoduodenectomy or sleeve gastrectomy * anticipation of 3 biliary anastomoses (we will include those anticipated to have 1 or 2 biliary anastomoses as detailed below) * pregnancy or breastfeeding * non-liver cancers (we will include certain patients with primary liver cancer as detailed below) * treatment with any investigational drug / device within 60 days prior to study entry * any other condition which in the judgment of the investigator would preclude adequate evaluation of the safety and efficacy of amscs * patients who are employees or relatives of the investigator
abdomen ct and open appendicectomy：new diagnostic and surgical procedures

Conditions: Wound Infection; Complication; Scar

Summary: the traditional open appendectomy in the clinical effect is not prefect, and for a long time there is no measurable improvement. the application of abdomen ct before surgery provides a new approach to the incision and new perception. in a randomized controlled trial of modified incision versus traditional incision. length of hospital day was the primary terminus, while operating time, postoperative complication, scar and time to resume normal activity and work as secondary terminus.

traditional open appendicectomy have many drawbacks, such as false-positive, cut infection, scar, extended cut, slower rehabilitation and return to work. in the past few years, in order to improve diagnostic accuracy, the abdomen ct is been general applied before appendicectomy, in addition to, a modified incision (mi) was designed based on it. using a mi compare traditional incision (ti) to the patient including cut extended, operating time, cut infection, false-positive rate, rehabilitation and return to work. it seems that mi would prove superior to ti in terms of hospital day (primary terminus), with operating time, postoperative complication, scar and time to resume normal activity and work as secondary terminus.

Eligibility criteria:
inclusion criteria: * patients with a clinical diagnosis of acute appendicitis exclusion criteria: * children under 14 are not included

Keywords: abdomen ct open appendicectomy