Kornimate/medical-research-clean huggingface dataset:
can cytokines be used as an activation marker

Conditions: Rheumatoid Arthritis

Summary: ra is a chronic, autoimmune, inflammatory disease that involves small joints in the form of symmetrical polyarthritis and progresses with exacerbations and remissions. pain, swelling, tenderness and morning stiffness are typical of the joints involved. although it is approached as a primary joint disease, a wide variety of extra-articular involvements may also occur. in this cross sectional study sedimentation rate (esr), c- reactive protein (crp), tumor necrosis factor (tnf)-α, soluble-tnf-α receptor (tnf-r), interleukin (il)-1b and il-10 were measured in three groups which were healthy volunteers, patients with ra in active period, and patients with ra in remission. tnf-r can be the main pathophysiological factor and a marker showing activation. tnf-r can be very important in revealing the effect of tnf on the disease and the value of this effect in the treatment and ensuring the follow-up of the disease with crp instead of esr in activation.

aims: the etiopathogenesis of rheumatoid arthritis (ra) is not clearly understood. however, role of the cytokines takes an important part of this mechanism. the investigators aimed to bring a new approach to the concept of 'remission' in patients with ra. background: ra is a chronic, autoimmune, inflammatory disease that involves small joints in the form of symmetrical polyarthritis and progresses with exacerbations and remissions. pain, swelling, tenderness and morning stiffness are typical of the joints involved. although it is approached as a primary joint disease, a wide variety of extra-articular involvements may also occur. it is an interesting pathophysiological process, the exact cause of which is still unknown, with many environmental, genetic and potentially undiscovered possible factors in a chaotic manner. objective: in this prospective study, sedimentation rate (esr), c- reactive protein (crp), tumor necrosis factor (tnf)-α, soluble-tnf-α receptor (tnf-r), interleukin (il)-1b and il-10 were measured in three groups which were healthy volunteers, patients with ra in active period, and patients with ra in remission. disease activity score-28 (das-28) was calculated in active ra and ra in remission. methods: this study included 20 healthy volunteers, 20 remission patients with ra and 20 active ra patients. venous blood samples were collected from patients in both healthy and ra groups.

Eligibility criteria:
inclusion criteria: healthy individuals and rheumatoid arthritis patients meeting american college of rheumatology (acr) ra remission criteria. exclusion criteria: smoking, using disease-modifying anti-rheumatic drugs (dmard) and/or anti-inflammatory drugs other than cortisol and methotrexate, receiving chemotherapy, being hypothyroid -

Keywords: c reactive protein erythrocyte sedimentation rate das-28 rheumatoid arthritis
clinical investigation and molecular forms of family disease of varicose

Conditions: Varicose Veins

Summary: the existence of a family factor in the genesis of varicose veins is certain, but few studies have addressed reliably instead of the genetic factor in clinical and molecular level. the investigator initiated an original study to identify one or more genetic abnormalities predisposing to varicose disease, based on a combined approach of genetic linkage and of exome sequencing. the clinical research phase is an essential prerequisite to the identification of genetic mutations; it is to identify large affected families and ensure an extremely rigorous and accurate phenotyping of individuals over several generations. a first clinical work has identified and / or phenotype 8 families with a genetically informative family suggesting autosomal dominant inheritance. linkage analysis suggested several candidate chromosomal regions without allowing the identification of a gene. this project aims to resume and expand the family clinical investigations and apply the techniques of genome analysis points, including exome sequencing on the most informative families to identify the genes and mechanisms responsible of this disease and improve the prevention and the treatment of varicose veins.


Eligibility criteria:
inclusion criteria: * any patient consultant the medicine vascular surgery for varicose veins of the lower limbs as part of a manifesto family context * varices presence in at least one family member * written consent exclusion criteria: * patients who are unable to sign or who refuse to sign an informed consent * subjects aged less than 25 years, due to the low penetrance of varicose disease that age. * secondary veins at a post-thrombotic disease (suspected by the examination and confirmed by doppler ultrasonography of the deep venous system) * venous angiodysplasia or secondary varicose arteriovenous fistulas.
treatment of acute lower limb ischaemia in sweden 1994-2014

Conditions: Acute Ischemia of Lower Limb

Summary: study of acute lower ischemia therapies based on data collected from the swedish vascular surgery registry between 1994 and 2014. primary endpoint is long term amputation-free survival and secondary end-points are 30 days and 1 year amputation-free survival as well as different revascularization techniques results and time trends.

the prospective swedish vascular registry (swedvasc) started in 1987 and since 1994 it has included more than 95 percent of the vascular surgical procedures performed nationwide. the registry has received extensive high internal and external validation. roughly 16000 open surgical and endovascular revascularisation procedures for acute limb ischemia have been performed during this period of time. the fact that every swedish citizen has a unique personal identification number makes it possible to obtain 100 percent accurate survival and amputation data. survival data were obtained through crosschecking the personal identification number with the national population registry in june 2016. this offers a unique opportunity to study a large population-based cohort of unselected patients.

Eligibility criteria:
inclusion criteria: * patients with acute limb ischemia * surgical procedure performed between 1 january 1994 and 31 december 2014 in sweden and registered in the swedvasc registry * infrainguinal occlusions exclusion criteria: * acute limb ischemia secondary to trauma, bleedings, dissection or graft infections. * suprainguinal occlusions.

Keywords: acute limb ischaemia(ali) acute ischaemia of the lower extremity thrombosis emboli endovascular surgery surgery amputation free survival long time survival demographics
computer-based cognitive training for parkinson disease

Conditions: Parkinson Disease; Gait

Summary: parkinson's disease (pd) is a neurodegenerative, progressive illness. it is a multi-system disease that influences not only the motor but also the cognitive and autonomic systems. the main cognitive impairment in individuals with pd is found in executive function (ef). ef is defined as a set of cognitive skills necessary for planning, monitoring and executing sequences of complex activities. the primary study hypothesis is that computer-based training aimed at improving executive function will have a beneficial effect on gait functions.

parkinson disease (pd) is a neurodegenerative, progressive illness. it is a multi-system disease that influences not only the motor but also the cognitive and autonomic systems. the main cognitive impairment in individuals with pd is found in executive function (ef). ef is defined as a set of cognitive skills necessary for planning, monitoring and executing sequences of complex activities. previous studies have revealed some relation between cognitive states and physical functions in healthy adults. few studies have examined the effect of computer-based cognitive training on various populations. these studies showed a positive emotional-cognitive effect in those populations. this type of intervention plan was also applied to pd patients. however, there are no reports on the effect of intentional cognitive training on gait functions. the purpose of the study is to assess whether cognitive training, designed to improve ef ability, can also improve gait function in pd patients.

Eligibility criteria:
inclusion criteria: 1. idiopathic pd. 2. aged 50-80, living in north region of israel. 3. receive regular medications for pd. 4. not suffering from irregular cognitive disturbance or mmse\<25. 5. measured 1-3 on the hoehn \& yahr scale. 6. have access to a computer and the ability to operate it. exclusion criteria: 1. brain operation, including dbs transplant. 2. history of orthopedic problems that can impair gait (hip/knee fractures and back problems). 3. orthopedic operation on lower limbs performed no later than six months prior to the beginning of the study. 4. unbalanced general health: uncontrolled diabetes or blood pressure, etc. 5. inability to walk independently. 6. immunodeficiency diseases, active cancer, ischemic diseases. 7. vision impairment, partial/full blindness. 8. having participated in similar research or cognitive assessment during the previous year. 9. have received cognitive or gait training under physical therapy or other programs.

Keywords: computerized cognitive training quality of life gait function executive function
first-in-man trial of nnc0142-0002 in patients with rheumatoid arthritis

Conditions: Inflammation; Rheumatoid Arthritis

Summary: this trial is conducted in europe. the aim of this clinical trial is to investigate the safety, tolerability, pharmacokinetic (the effect of the body on the investigated drug) and signs of clinical efficacy of increasing single doses or four repeated doses of nnc 0142-0002 in patients with rheumatoid arthritis.


Eligibility criteria:
inclusion criteria: * active rheumatoid arthritis, characterized by a disease activity score (das28) above 3.2, and a diagnosis of at least three months duration * aged between 18 and 75 years (both inclusive) * subjects on stable doses of methotrexate for at least 4 weeks prior to dosing * use of highly effective contraception during the trial (both males and females) exclusion criteria: * a chronic inflammatory autoimmune or joint disease other than ra (rheumatoid arthritis) * an active or latent tuberculosis * any investigational or experimental therapy within 4 weeks or 5 half-lives (whichever is longer) prior to the screening visit * a known significant cardio-vascular disease * vaccination against live virus or bacteria within 4 weeks prior to randomization * the use of concomitant medications that are prohibited in the trial (e.g., certain dmards (antirheumatic therapies that are disease modifying), biologics (here: biotechnologically produced antibodies), intra-articular corticoid-injections, etc.) * a positive test result for human immunodeficiency virus (hiv) infection, hepatitis b and/or hepatitis c, or tuberculosis skin test * donation of greater than or equal to 400 ml of blood within 8 weeks prior to trial entry
evaluation of short enteral nutrition in the emergency room for bronchiolitis with main nutritional impairment

Conditions: Bronchiolitis

Summary: the winter epidemic of bronchiolitis in infants poses insurmountable difficulties for the hospital system for the 2022-2023 season globally. these difficulties are linked to the combination of an unusual epidemic intensity and the loss of medical and paramedical caregivers in the hospital leading to the closure of beds since the covid-19 pandemic. bronchiolitis in youngest and most vulnerable infants can lead to severe clinical pictures requiring hospitalization. among them, some infants present exclusively with inability to eat and only require continuous enteral nutrition during their hospitalization. a service protocol has been put in place in the pediatric emergency room of the hôpital femme mère enfant for the 2022-2023 season to carry out short enteral nutrition and monitoring before returning home. this outpatient care would aim to reduce the effect of hospital saturation during the winter epidemic of bronchiolitis, increase the comfort and satisfaction of families by allowing less disruption of family life and prevent nosocomial infections. a retrospective evaluation of the feasibility and effectiveness of this protocol is necessary to rely on this first experience of outpatient management.


Eligibility criteria:
inclusion criteria: * children being treated according to our short-term enteral nutrition protocol exclusion criteria: * parents refusal

Keywords: infant bronchiolitis enteral feeding
screening, brief intervention, and referral to treatment for drug use

Conditions: Drug Abuse

Summary: screening, brief intervention, and referral to treatment (sbirt) is a comprehensive, integrated public health approach to identify and deliver a spectrum of early detection and intervention services for substance use in general medical care settings. these settings, such as emergency department visits, offer a potential "teachable moment" because patients may have perceptions of vulnerability about their health, and therefore be particularly receptive to screening and counseling. there is mounting scientific evidence suggesting sbirt is effective in reducing alcohol use at varying levels of severity in a myriad of health care settings including primary care, emergency departments, and trauma centers. although the sbirt approach has shown promise for alcohol, relatively little is known about its effectiveness for adult illicit drug use specifically. this will be among the first studies to rigorously test the sbirt approach for drug use. it will evaluate the effectiveness of sbirt for drug use and related factors for 700 multi-ethnic ed patients using a two-group randomized repeated-measures design in which biologically-validated drug use abstinence and related outcomes of an intervention group are compared to those of an attention-placebo control group. over a 14-month period, bilingual/bicultural health educators recruited participants who reported past 30-day illicit drug use in excess of risky alcohol use from the waiting areas of two large hospital's ed and trauma units. following consent procedures and standardized baseline assessments, health educators randomly assigned participants to one of the two conditions. the intervention group received "life shift," an sbirt drug use intervention matched to the participant's drug use risk level. the control group received the same type and quantity of intervention in an unrelated area-driving and traffic safety ("shift gears" program), also matched to their driving/traffic risk level. a 6-month face-to-face follow-up visit by trained measurement technicians blind to the participant's assigned condition collected standardized self-report past 30-day drug use measures (asi-lite)and hair samples for validating self-reported abstinence. additional outcome variables are changes in the frequency of drug use, functional status measures (i.e., medical problems, psychiatric problems, and alcohol use), and health care utilization.


Eligibility criteria:
inclusion criteria: * 18 or over * speak english or spanish * competent to give consent and interact * drug use risk higher than alcohol use risk exclusion criteria: * under 18 * non english or spanish speaker * no telephone where one can be reached * too injured/sick to participate * alcohol use risk higher than drug use risk

Keywords: drug use; emergency department; brief intervention
effect of aqw051 on cognitive function in patients with chronic stable schizophrenia

Conditions: Schizophrenia Disorders

Summary: this poc study is designed to assess the cognitive effects of doses of aqw051 in patients with chronic stable schizophrenia.


Eligibility criteria:
inclusion criteria: 1. diagnosis of schizophrenia 2. symptomatically stable and currently treated with a stable regimen for at least 3 (three) months prior to dosing with one of the following second generation of antipsychotics: risperidone, paliperidone, quetiapine, ziprasidone, aripiprazole. 3. specific cognitive impairment 4. smokers and non-smokers exclusion criteria: 1. current treatment with an anticholinergic or other agent known to adversely interfere with the cholinergic system, and/ or treatment with cholinesterase inhibitor within the last three (3) months prior to dosing. 2. current treatment with conventional antipsychotics (e.g fluphenazine, haloperidol) or clozapine. 3. history of neuroleptic malignant syndrome. 4. diagnosis of substance abuse (other than nicotine) within the last month and alcohol or substance dependence (other than nicotine) within the last 6 months. 5. any clinically significant suicidal ideation (type 4 or 5 on the columbia-suicide severity rating scale (c-ssrs) in the last month) or previous history of suicide behavior other protocol-defined inclusion/exclusion criteria may apply

Keywords: hallucinations, psychotic, delusions, cognitive deficits
comparison of two endoscopically placed nasojejunal probes

Conditions: Investigation Time

Summary: a direct application of jejunal tube feeding is necessary especially in patients with gastroparesis due of existing diabetes mellitus, postoperative or severe underlying disease. since the jejunal tube feedings, the secretion of gastric juice can be increased, the use of probes that allow both: jejunal nutrition, as well as a gastric outflow of secretions are beneficial. while in a randomized trial of schwab et al. it could be shown that the use of freka-trilumina® compared to dobbhoff probe by so-called drag technique is significantly faster there are currently no comparative data to use the easy-in® probe subsequently developed , which is directly introduced through the working channel of the endoscope, and thus shortening the procedure time.

the use of probes nasojejunal has increasingly become important especially in critically ill patients because of the beneficial effect in patients e.g. with necrotizing pancreatitis, according trauma or major surgical procedures. a direct application of jejunal tube feeding is necessary especially in patients with gastroparesis due of existing diabetes mellitus, postoperative or severe underlying disease. since the jejunal tube feedings, the secretion of gastric juice can be increased, the use of probes that allow both: jejunal nutrition, as well as a gastric outflow of secretions are beneficial. while in a randomized trial of schwab et al. it could be shown that the use of freka-trilumina® compared to dobbhoff probe by so-called drag technique is significantly faster there are currently no comparative data to use the easy-in® probe subsequently developed , which is directly introduced through the working channel of the endoscope, and thus shortening the procedure time. in the presented study should be investigated to what extent the use of imported directly via the working channel easy-inn® probe, application time and thus the investigation period may be shortened compared to the usual nasojenunal probes.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * clinical indication for enteral feeding via naso-jejunal probe exclusion criteria: * lack of consent of the patient or their relatives (in intubated and mechanically ventilated patients in intensive care)
shoulder eccentric external rotator training for subacromial pain syndrome

Conditions: Subacromial Impingement Syndrome

Summary: the purpose of this study is to examine the effects of eccentric exercise to the shoulder muscles for people with shoulder pain. identifying specific exercise protocols for individuals with shoulder pain will provide evidence to help clinicians select the best interventions.

prior investigations for eccentric training of the shoulder have primarily utilized a pain provocation model for exercise progression. this method of progressing resistance training load and volume assumes that pain must be increased during the exercise movement for clinical benefit to occur. when the individual reports a reduction in pain, load is increased so that the provoking pain level returns. the contrast to this approach would be a performance based progression as utilized in the blume et al study for shoulder eccentric training. this method progresses a patient based on ability to perform a higher number of repetitions at a given load without increasing symptoms which could be favorable in many clinical settings. further investigation on the role of eccentric training, specifically to the shoulder external rotators, in patients with saps is warranted. thus, the aim of this investigation was to compare outcomes, for individuals diagnosed with saps, performing a six week protocol of eccentric training to the shoulder external rotators compared to a general exercise protocol.

Eligibility criteria:
inclusion criteria: * presence of non-acute shoulder pain (greater than 3 months duration) * 3 out of the 6 following tests positive, neer impingement, hawkins-kennedy impingement, empty can test, resisted external rotation test, palpable tenderness at the insertion of the supraspinatus or infraspinatus, and painful arc from 60° to 120° during active abduction. * age over 18 years old * sufficient ability to read english as required for completing questionnaires exclusion criteria: * red flags noted in the patient's medical screening questionnaire (msq) (ie. tumor, fracture, metabolic diseases, rheumatoid arthritis, osteoporosis, prolonged history of steroid use) * full thickness supraspinatus or infraspinatus tendon tear as determined by a positive drop arm test, lag sign or rent test. * shoulder adhesive capsulitis as evidenced by a limitation in passive motion for all shoulder planes of movement. * having an upper extremity amputation. * individuals having a history of surgery to the cervical spine or involved upper extremity for a musculoskeletal, neurological or dermatological condition for which they are at the time of data collection receiving post-operative care. * pending legal action regarding their shoulder pain * inability to comply with treatment and follow up schedule * insufficient english language skills to complete all questionnaires

Keywords: shoulder eccentric training subacromial impingement syndrome