Kornimate/medical-research-clean huggingface dataset:
pain informed movement program in patients with post covid-19 condition

Conditions: Post COVID-19 Condition

Summary: patients who have undergone covid-19 infection often have long-term sequelae. one of the most prevalent sequelae is pain. the main objective of this research is to investigate the efficacy of pain informed movement program in patients with post covid-19 condition experiencing persistent pain. through the implementation of this program, the investigators seek to determine whether such intervention can offer significant improvements in reducing pain intensity and interference, catastrophizing, kinesiophobia, and functionality of affected patients.


Eligibility criteria:
inclusion criteria: * patients of both sexes. * agreed to participate. * post covid-19 condition patients meeting the who definition for this disease. * patients with moderate or severe pain were included, the cut-off point on the visual analogical scale (vas) being pain greater than or equal to 3.5 cm. exclusion criteria: * pulmonary, cardiac, neurological, vascular, or orthopaedic pathologies that could limit the execution of the evaluation and intervention. * cognitive impairment that prevented them from understanding and answering the questionnaires. * patients suffering from a reinfection with sars-cov-2. * patients with a history of severe or critical covid-19 disease severity. * patients who had pre-existing chronic pain according to the current iasp definition. * patients participating in other studies.
coached, coordinated, enhanced neonatal transition (ccent)

Conditions: Prematurity

Summary: this study will evaluate a new neonatal follow-up model that offers additional support and coping resources for parents during their child's nicu admission as well as during their transition home. the coached, coordinated, enhanced neonatal transition (ccent) model involves a key worker who will be the primary support for families during the first year of their child's life. the key worker's role involves 1) parental coaching using an acceptance and commitment therapy approach, 2) coordinating care across various levels of care as well as supporting families in system and resource navigation, and 3) provided proactive education targeting normal challenges in caring for a child who required intensive care support. the goal is to improve the psychosocial support and medical care coordination beyond the neonatal intensive care unit as many of the medical and social concerns do not end at the time of discharge. primary objective is parent stress at 12 months.


Eligibility criteria:
inclusion criteria (meets at least one of the following criteria): 1. infant born ≤ 26+6 weeks of gestational age (ga) 2. infant born between 27-29+6 weeks ga with ≥ 1 of the following risk factors: i)≥ grade iii intraventricular hemorrhage with post hemorrhagic hydrocephalus ii)retinopathy of prematurity requiring intraocular bevacizumab/ anti-vascular endothelial growth factor or laser surgery therapy iii)requires invasive (e.g., intubated) or non-invasive (e.g., cpap or bipap) at ≥ 34 weeks ga and/or supplemental oxygen at ≥ 37 weeks gestational age iv)requires surgery for management of necrotizing enterocolitis (nec)- stage 3 3. infant with ≥ 2 major congenital anomalies as defined by eurocat(13) (e.g., congenital heart disease, spina bifida, cleft palate, etc. not including minor congenital anomalies, e.g., dysmorphic facies), and length of stay in recruiting institution ≥ 14 days. 4. infant with hypoxic ischemic encephalopathy (hie) requiring therapeutic hypothermia and in the recruiting institution for ≥ 14 days. exclusion criteria: 1. families that do not speak english or french 2. parent will not be involved with child's care over the entirety of the study period (2 years) (e.g., adoption). 3. infant will be followed by an out-of-province neonatal follow-up program or lives a significant distance from the neonatal follow up program and therefore not routinely followed by the team. 4. infant that has previously been discharged home from the nicu/hospital. 5. decision/high likelihood of decision for act of withdrawal of care by clinical teams/families

Keywords: neonatal intensive care unit mindfulness care coordination anticipatory guidance parental support neonatal follow-up acceptance and commitment therapy
effect of colchicine on the incidence of atrial fibrillation in open heart surgery patients

Conditions: Arrhythmia

Summary: this study evaluates the role of colchicine in the prevention of atrial fibrillation in patients undergoing open heart surgery. half of participants will receive colchicine and the other half will not

atrial fibrillation (af) is the most common arrhythmia in patients undergoing cardiac surgery and is estimated to occur in 26% of all cardiac surgery patients. it can lead to increase morbidity, mainly due to hemodynamic instability and thromboembolic complications, and to increased hospital stay with its associated higher health care cost. previous studies have demonstrated that increased inflammation may precede af and, therefore, interventions that reduce the inflammatory process may help reduce the incidence of af. colchicine has potent anti-inflammatory properties and may therefore be capable of reducing the incidence of af. this study aims to determine whether the administration of colchicine starting the day before cardiac surgery and continuing until discharge may lead to reduction in post-operative af.

Eligibility criteria:
inclusion criteria: * all consecutive adult patients undergoing elective cardiac surgery exclusion criteria: * documented history of af or supraventricular arrhythmia or, absence of sinus rhythm on hospital admission * known severe liver disease or current transaminases \>1.5 times the upper normal limit * current serum creatinine \>2.5 mg/dl * known myopathy or elevated baseline preoperative creatine kinase * known blood dyscrasias * significant gastrointestinal disease * pregnant and lactating women * known hypersensitivity to colchicine * current treatment with colchicine for any indications * emergency surgery

Keywords: atrial fibrillation colchicine cardiac surgery
the effect of a non-operating room anesthesia (nora) safety video on clinician anxiety and perceived self-efficacy

Conditions: Anxiety; Self Efficacy

Summary: the purpose of this study is to assess the effect of a non-operating room anesthesia (nora) safety video on clinician anxiety and perceived self-efficacy.

50 anesthesia professionals will be recruited from the center for surgical innovation (csi) non-operating room anesthesia (nora) workforce. participants will be asked to: complete a five-minute pre-survey, watch a five-minute video, and then complete a five-minute post-survey.

Eligibility criteria:
inclusion criteria: * individuals employed at dartmouth-hitchcock medical center (dhmc) in the department of anesthesia who are eligible to work in the center for surgical innovation (csi). exclusion criteria: * individuals who are not employed at dartmouth-hitchcock medical center (dhmc) in the department of anesthesia and who are not eligible to work in the center for surgical innovation (csi).
comparison on efficacy and safety of three inpatient insulin therapy in type2 dm

Conditions: Diabetes Mellitus (DM)

Summary: purpose: to compare efficacy and safety of traditional sliding scale insulin (ssi) versus modified 70/30 insulin versus modified basal plus supplemental scale /bolus insulin regimens for glycemic control in hospitalized diabetic patients with diabetes. methods: in a prospective trial, patients with diabetes will be randomized to receive either traditional hospital ssi , or twice daily 70/30 insulin plus supplemental lunchtime insulin for bg ≥ 150 mg/dl or once every night glargine plus three times prandial glulisine for bg ≥ 150 mg/dl . 70/30 insulin and glargine will be started respectively at 0.4 and 0.2 u/kg/day for bg ≤ 200 mg/dl or 0.5 and 0.3 u/kg/day for bg above 200 mg/dl.


Eligibility criteria:
inclusion criteria: * known history of type 2 dm for longer than 3 months * age between 18-64 year old, * treatment with diet alone, any combination of oral antidiabetic agents and/or insulin before admission. exclusion criteria: * subjects with hyperglycemia without any known history of dm * presence of diabetic ketoacidosis (dka) * patients admitted to intensive care unit (icu) * subjects expected to undergo surgery during the hospitalization course * patients with clinically relevant hepatic disease impaired renal function (serum creatinine ≥ 3.0 mg/dl) systemic infections pregnancy patients on medications known to interfere with the blood glucose level (either increasing or decreasing

Keywords: type 2 d m sliding scale insulin 70/30 insulin basals insulin supplemental insulin
combined constraint therapy and bimanual therapy for children with unilateral brain injury

Conditions: Hemiplegia; Cerebral Palsy

Summary: to examine efficacy of combined unimanual and bimanual intensive therapy in children with unilateral brain injury. a key question in hemiplegia therapy is whether the affected hand should be trained alone or in tandem with the other hand. in constraint-induced movement therapy (cimt), a participant's less-affected upper extremity is restricted with a sling, cast, or mitt, while the participant actively uses the affected arm and hand in skill-based therapeutic activities. bimanual therapy, in contrast, engages both hands in therapeutic movement. since constraint and bimanual therapy target different aspects of hand use, they could have synergistic effects on hand function when given in combination.

children with hemiplegia will be given an intensive hand therapy protocol for six weeks (6 hrs/day, 5 days/week - total of 180 hours. therapy will be given in two blocks. in one block (3 weeks, 90 hours of therapy), children will receive constraint-induced movement therapy (cimt), also known as constraint therapy. during cimt, children wear a mitt over their less-affected hand, which restricts use of that hand. children engage in intensive therapy to improve active range of motion, strength, motor control and sensory awareness of the affected hand. activities are functional and play based. daily structure of therapy includes: morning gym, fine motor, gross motor, sensory motor, therapeutic feeding, sports and self care activities. during training, children perform play-based and functional activities with the affected hand. example activities include playing card and board games, arts and crafts, and activities that provide sensory stimulation to the affected hand, such as finger painting. activities also include stretching and strengthening exercises. in one block (3 weeks, 90 hours of therapy), children will receive bimanual therapy. during bimanual therapy, children do not wear a mitt over the less-affected hand. children will be provided individualized activities that facilitated active use of both hands. therapists will adapt and grade activities and guided children to problem solve for success. bimanual activities include self-care (tying shoes, zippering, cutting food), sports activities, and manipulation of classroom tools (cutting with scissors). before the intervention begins, children will be randomized to one of two arms. in arm 1, children will receive 3 weeks of cimt followed by 3 weeks of bimanual therapy. in arm 2, children will receive 3 weeks of bimanual therapy followed by 3 weeks of cimt.

Eligibility criteria:
inclusion criteria: * diagnosis of hemiplegia. * wrist range of motion of at least 10 degrees. * able to follow directions. * experience attending day programs without the child's home caregiver present (i.e. school, daycare). exclusion criteria: * uncorrected vision problems. * inability to communicate or follow directions.

Keywords: hemispherectomy brain hand function
merck carotid atherosclerosis trial (mk-0000-111)(completed)

Conditions: Carotid Atherosclerosis

Summary: this study will examine the effect of statin and niacin therapy on carotid plaque biomarkers


Eligibility criteria:
inclusion criteria: * patient is diagnosed with carotid stenosis and is scheduled to undergo carotid endarterectomy * female patients of reproductive potential must abstain from sex or use an acceptable method of birth control through out the study exclusion criteria: * patient must undergo cea less than 4 weeks after entering study * patient has recent history of acute coronary syndrome * patient has has coronary artery bypass graft surgery within 30 days of study start * patient has thyroid disease that has not been treated for more than 6 weeks * patient has donated blood within 8 weeks of study start * patient has poorly controlled diabetes mellitis * patient has human immunodeficiency virus (hiv) or hepatitis b or c * patient is taking warfarin or other anticoagulants * patient is taking hormone replacement therapy
18f-fdg pet/tc in tir3a e tir3b

Conditions: PET / CT; FDG PET/CT; Cytology; Thyroid Nodules

Summary: the primary objective of this study is to evaluate the diagnostic performance of 18f-fdg pet/ct performed by normal care pathway in the identification of malignancy of undetermined resulting thyroid lesions at cytology (tir3a and tir3b) comparing the 18f-fdg pet/ct result with histological data. the secondary objective is to identify possible pet/ultrasound/genetic/radiomics variables that can more accurately define the potential malignancy of undetermined nodules and create a predictive model of malignity fed by standard parameters (derived from the normal care path). the identification of the prognostic value of 18f-fdg pet/ct in such patients setting could, in fact, make the pet useful in the future in the selection of patients for surgery/ follow-up.

to better stratify the malignancy risk of the resulting undetermined cytological lesions (tir3a and tir3b), it is proposed to perform an 18f-fdg pet/tc survey in these patients by which semiquantitative parameters are derived (suvmax, suvmean, suvpeak, mtv, tlg) and perform radiomatic analysis. in the case where the above mentioned pet/ct survey has been recently performed, the survey will not be repeated but the images will be reviewed with visual and semi-quantitative analysis. the results will be compared with those derived from ultrasound and genetic analysis (currently proposed in cases of tir3a), with the subsequent histological examination derived from surgery (currently indicated by the normal care path in tir3b cases and in case of reconfirmation of tir3a cytology to a second needle aspiration on the nodule). it is expected that an algorithm with multiple parameters combined can be created to correctly point towards surgery or a conservative attitude of follow up.

Eligibility criteria:
inclusion criteria: * patients with undetermined cytology (tir3b and tir3a candidates for surgery) and 18f-fdg pet/ct; * obtaining informed consent for data collection and processing. * patient aged 18 years exclusion criteria: - pregnant/breastfeeding women

Keywords: pet/tc cytology 18f-fdg thyroid nodules
tolerance and effect on intraocular pressure after administration of syl040012

Conditions: Ocular Hypertension; Glaucoma

Summary: the purpose of this study is to determine whether syl040012 is safe for the treatment of ocular hypertension and glaucoma.


Eligibility criteria:
inclusion criteria: * healthy volunteers, any gender * 18 to 45 years of age, * subjects must provide signed informed consent prior to participation in any study-related procedures * body mass index between 19,5 and 29 kg/m2 * iop \</= 21 mmhg in both eyes * have a bcva (best corrected visual acuity) of \>/= 0.8 (20/25) (snellen scale), or \</= 0.1 (logmar units)in both eyes * normal fluorescein clearance test in both eyes * normal funduscopy in both eyes exclusion criteria: * pregnant or breastfeeding females or those with a positive pregnancy test. females of childbearing potential who will not use a medically acceptable contraceptive method from selection and during the hole study. * current relevant disease, including respiratory disease, cardiovascular, endocrine, neurological, haematological, renal, neoplastic, hepatopathy, gastrointestinal distress, hypertension, or infectious acute processes * previous chronic processes or with rebound characteristics that could interfere with study according to the investigator's judgment. * volunteers who have received pharmacological treatment, including medicinal plants, during the four weeks previous to beginning the study. * having used anti-cholinergics, betablockers and corticoids sporadically in the last 30 days whichever the route of administration, or any med by ocular or nasal administration route. * case history of hypersensitivity to meds or any other allergic process * visual alterations: previous eye surgery, glaucoma, uveitis or ocular surface pathology (dry eye, blepharitis). * volunteers with visual alteration with more than 3 dioptres in either eye * use of contact lenses * volunteer who has participated in a clinical trial during the past four months before study entry. * blood or derivate transfusion during the six previous months to study entry * case history of drug or alcohol abuse or dependence. * positive result in test drug abuse during selection period * positive serology results to hepatitis b virus (hbsag), virus c or hiv * analytic alterations medically relevant, at investigator's judgement.

Keywords: ocular hypertension glaucoma beta-blocker
zonulo-hyaloido-vitrectomy for malignant glaucoma

Conditions: Malignant Glaucoma

Summary: the purpose of this study is to assess the zonulo-hyaloido-vitrectomy for malignant glaucoma through an anterior approach.


Eligibility criteria:
inclusion criteria: * patients who underwent the zonulo-hyaloido-vitrectomy for malignant glaucoma through an anterior approach exclusion criteria: * systemic disease or inflammation

Keywords: malignant glaucoma zonulo-hyaloido-vitrectomy
an efficacy trial of electroacupuncture at points of bilateral bl33 for mild and moderate benign prostatic hyperplasia

Conditions: Benign Prostatic Hyperplasia (BPH)

Summary: to evaluate efficacy of bl33 for mild and moderate benign prostatic hyperplasia(bph).there are trials showing that electroacupuncture on bl33 for mild and moderate bph is more effective than terazosin. it could reduce the international prostate syndrome score (ipss) by 6.68±2.84(39.79%),lower urinary symptoms bother of score(bs) and bladder residual urine, and increase maximum urinary flow rate.but the efficacy of bl33 has not been studied. the objective of this study is to evaluate efficacy of bl32 for mild and moderate bph by comparison with non-acupoint group.

efficacy here means specific effect(or active ingredient) of the point bl33.

Eligibility criteria:
inclusion criteria: * 50-70 years old * mild to moderate bph evaluated by i-pss * patients having urinary dysfunction more than 3 months * patients with stable life signs * no use of α1 receptor blocker, 5α-reductase inhibitor or traditional chinese medicine for over 1 week * volunteer to join this research and sign the written informed consent prior to receiving treatment exclusion criteria: * urinary dysfunction caused by gonorrhea or urinary tract infection * oliguria and anuria caused by urinary calculi, prostate cancer, bladder tumor and acute/chronic renal failure * urinary dysfunction caused by neurogenic bladder, bladder neck fibrotic and urethral stricture * failure of invasive therapy for prostatic obstruction * injured local organs, muscle and nerve caused by pelvic operation or historical trauma * upper urinary obstruction and hydrocele combined with damaged renal function due to bph diagnosed by b-ultrasound * patients who can't stick to treatment because of economic reason, far distance between home and the hospital or difficult walking etc.

Keywords: acupuncture mild and moderate bph
serum ferritin concentration and fetal mca doppler as predictors for preterm delivery

Conditions: Preterm Delivery

Summary: pregnant women with iron deficiency anemia during third trimester will be assessed for serum ferritin and peak systolic value for fetal middle cerebral artery to find out their correlation with preterm delivery.

preterm delivery, defined as delivery before 37 weeks of completed gestation (259 days), is a major cause of neonatal morbidity and mortality. despite extensive research, preterm birth still accounts for 5-10% of all deliveries in developed countries and rates are on the increase, including in the uk. while mortality associated with preterm delivery has declined due to use of antenatal steroids and improvements in neonatal intensive care, preterm babies still remain at risk of major complications. these include respiratory distress syndrome, necrotising enterocolitis, retinopathy of prematurity, sepsis, intraventricular haemorrhage, periventricular leucomalacia and long-term cognitive and sensory impairment. two major determinants for the mortality and morbidity of babies born preterm are gestation at delivery and birthweight. prematurity therefore carries significant cost implications to both healthcare services and society in general. high hemoglobin along with anemia was examined in an observational study. at entry to care, which ranged between 6 and 8.4 wk gestation, women with hemoglobin levels exceeding 130g/l had a greater than twofold increase in risk of preterm delivery and infant low birth weight. neither risk was statistically significant, however, because of the small numbers with high hemoglobin. similarly, a concentration of the iron storage protein, ferritin, that is high for the third trimester of pregnancy is also associated with an increased risk for preterm and very preterm delivery. over the last twenty years, interest has been shown in using ultrasound parameters or doppler studies of fetal blood to assess fetal anaemia. middle cerebral artery doppler has taken over and has replaced amniocentesis as a screening test for fetal anaemia in high risk pregnancies.

Eligibility criteria:
inclusion criteria: * pregnant female from 24 weeks till 37 weeks gestation. * patients diagnosed as iron deficiency anemia. exclusion criteria: * medical disorders as hypertension or diabetes. * kidney and liver diseases. * any other causes of anemia as haemoglobinopathies.

Keywords: ptd