Kornimate/medical-research-clean huggingface dataset:
improving shared-decision making in the intensive care unit using patient-reported outcome information

Conditions: Intensive Care Unit Syndrome; Patient Engagement

Summary: the aim of this study is to evaluate the effect of incorporation of outcome information in the intensive care unit (icu) decision-making process on patient and family reported outcomes and experiences of patients, relatives and icu clinicians in a randomized clinical trial design in the jeroen bosch ziekenhuis and radboudumc in the netherlands.

background due to advances in critical care medicine, more patients survive their critical illness. however, many intensive care unit (icu) survivors suffer from physical, cognitive and/or mental problems impacting patients' quality of life (qol). because of a lack of long-term outcome information, icu physicians make decisions regarding icu treatment based on their clinical experience and intuition. moreover, patients and relatives are often not involved in the decision-making process. to improve the icu decision-making process and to make it more substantiated, the use of patient-reported outcome measures (proms) is of utmost importance. therefore, the radboudumc, in collaboration with six regional hospitals, including jeroen bosch ziekenhuis (jbz), set up a large-scale prospective cohort study, monitor-ic (www.monitor-ic.nl), to study long-term outcomes of icu survivors', their qol and their needs. this research sets out to evaluate the effect of incorporation of outcome information in the icu decision-making process on patient and family reported outcomes and experiences of patients, relatives and icu clinicians in a randomized clinical trial design in the jeroen bosch ziekenhuis and radboudumc in the netherlands. methods a prediction model for long-term qol was previously developed using physiological, pathological, drug and treatment data from patients' electronic health record combined with proms from one centre of the monitor-ic. it was externally validated with the data of six other centres and an e-health tool was developed, incorporating this prediction model. for this research, the e-health tool will be incorporated in family meetings.

Eligibility criteria:
inclusion criteria: * patients admitted to the icu for 12 hours or more * patients (or their legal representative) provide written informed consent exclusion criteria: * patients admitted to the icu due to a covid-19 infection * moribund patients

Keywords: share decision making intensive care unit quality of life
restoring normal sagittal thoracic posture improves management outcomes in patients with chronic nonspecific neck pain

Conditions: Rehabilitation

Summary: because changes in sagittal thoracic alignment have been reported to alter the mechanical loading of the cervical spine and decreased thoracic mobility has been identified as one of the predictors for neck and shoulder pain , it makes sense that thoracic articular treatment improves local kinematics and simultaneously neck pain improves. the purpose of this study is to investigate the effects of a multimodal program, with thoracic hyper kyphosis rehabilitation using the denneroll™ thoracic traction orthosis , applied to participants with chronic non-specific neck pain and thoracic hyper-kyphosis.

interventions directed at improving hyper-kyphosis of the thoracic spine may have therapeutic effects on the cervical spine; however, there is a lack of controlled studies evaluating this. the purpose of this study is to investigate the effect effects of a multimodal program, with thoracic hyper kyphosis rehabilitation using the denneroll™ thoracic traction orthosis , applied to participants with chronic non-specific neck pain and thoracic hyper-kyphosis. in this study, 80 participants, with chronic non-specific neck pain and thoracic hyper-kyphosis will be included. participants will be randomly assigned to the control or an intervention group. both groups will receive the multimodal program; additionally, the intervention group received the denneroll™ thoracic traction orthosis. outcome measures will include kyphotic angle (max.), neck pain and disability , sensorimotor control outcomes; head repositioning accuracy , smooth pursuit neck torsion test and overall stability index . measures will be assessed at three intervals: baseline, 10 weeks, and 6 months after cessation of treatment.

Eligibility criteria:
inclusion criteria: * neck pain for more than 3 months * thoracic angle measured more 55 degrees exclusion criteria: * any signs or symptoms of medical "red flags", * a history of previous spine surgery. * signs or symptoms of upper motor neuron disease. * vestibulobasilar insufficiency. * amyotrophic lateral sclerosis. * bilateral upper extremity radicular symptoms.

Keywords: randomized controlled trial posture kyphosis neck pain
tumor deposits in colorectal cancers

Conditions: Extranodal Extension

Summary: tumor deposits (tds) are emerging as an adverse prognostic factor in colorectal cancers (crcs), but they are quite ignored in the current staging system. previous proposals to incorporate tds in node stage or consider them distant metastases raised some doubt. the authors propose a new staging system to optimize treatments.

tumor deposits (tds) are emerging as an adverse prognostic factor in colorectal cancers (crcs).in the current staging system tds are somewhat neglected. it has been proposed to add td count to the number of metastatic lymph nodes or to consider tds as distant metastases, but the scientific basis of these proposals seems dubious and not supported by robust statistical analyses. the investigators supposed that splitting the three sub-stages of the stage iii crc according to absence or presence of tds could be an easy and useful method to avoid the loss of crucial information. the proposed study will include 243 stage iii crc patients undergoing radical surgery and adjuvant chemotherapy. each new substage, according to absence or presence of tumor deposits, will be analyzed with sophisticated statistical analysis (particularly the area-under-curve (auc), calculated by the time-dependent receiver-operating-characteristic (roc) curve for censored survival data) to individuate if this new staging does better the current one.

Eligibility criteria:
inclusion criteria: * colorectal cancers in stage iii tnm undergoing radical surgery and adjuvant chemotherapy exclusion criteria: * lynch syndrome * rectal cancer undergoing neoadjuvant (radio)chemotherapy * colorectal cancers without metastatic nodes * metastatic colorectal cancers * eligible patients refusing adjuvant chemotherapy

Keywords: tumor deposits colorectal cancers tnm staging system roc curve
falciformopexy for treatment perforated peptic ulcer.

Conditions: Perforated Peptic Ulcer

Summary: use the falciform ligament flap for the treatment of perforated peptic ulcer

peptic ulcer perforation (pup) is one in all the foremost common critical surgical emergencies. the omentum flap is usually wont to cover a pup. however, the omentum can not be utilized in cases of severe peritonitis or previous surgical removal. this is often the primary study conducted in vietnam that was designed to analyse the outcomes of patients with pups who were treated using the ligament. in the population, the prevalence of ulcer disease supported physician diagnosis ranges from 0.12% to 1.50%, and hospitalization rates range from 0.10% to 0.19%. ulceration perforation (pup) is one of the foremost common surgical emergencies worldwide, which is necessitate emergent surgical intervention. the death rate of pups is between 1.3% and 20%, and mortality thanks to a perforation of a gastric ulcer is over mortality because of a perforation of a duodenal ulcer (40% vs 10%) . some studies have shown that having comorbidities, being over 70 years old, undergoing surgical procedure after 36 h, pup diameter greater than 1 cm2 and postoperative com- plications are associated with mortality. the technique of using the omental patch for repair pup is commonest now thanks to mobility and vascularity but is also using the falciform ligament in some cases due to highly vascularity. the technique of using the falciform ligament for the treatment of pups was reported in 1978 by fry . the purpose of the study was to explain the technique and therefore the results of using the falciform ligament for the treat- ment of pups during a large volume surgical centre in assuit university hospital found the falciform patch to be a successful technique in repair pup and is assumed to be as effective as omental patch but more advantage because of highly vascular.

Eligibility criteria:
inclusion criteria: - any cases presented with ppu within age from 18 till 70 years. exclusion criteria: * malignancy. * previous git and liver surgery. * nonoperative treatment.
prevalence of wound healing disturbances in geriatric inpatients (wonder study)

Conditions: Wound Healing Disorder; Malnutrition

Summary: in geriatric patients, there is a plethora of nutritional and illness-related parameters, resulting in a complex situation which hampers identification of risk factors.in the planned prospective study, the point and period prevalence of wound healing disorders (whd) is examined at admission and at discharge in a cohort of 517 male and female geriatric patients. as the investigators are also interested to study the occurrence of whd in patients with malnutrition (and other geriatric phenomena) compared to the prevalence of whd in patients with a good nutritional status.

the investigators will determine the prevalence of impaired wound healing upon admission to the hospital as well as the incidence of new wound healing disorders during hospital stay with specific focus on malnutrition and other important nutritional parameters in geriatric patients. therefore the investigators intend to study consecutively admitted patients both at admission and at discharge and monitor them during hospital stay. the investigators will investigate the associations between the individual nutritional status and body composition parameters (such as sarcopenia) and whd in geriatric patients, taking both medical variables and the frailty syndrome into account.

Eligibility criteria:
inclusion criteria: * age ≥ 60 years * informed written consent * normal cognitive status according to mini-mental state examination (mmse ≥ 24 points) * life expectancy of \> 3 months according to treating doctor * proficient in german exclusion criteria: * lack or incapacity of informed consent * mmse \< 24 * life expectancy \< 3 months according to assessment by the attending physician * short term patients (\< 3 days of hospital stay) * lack of german language

Keywords: geriatrics frailty
tai chi in spondyloarthritis

Conditions: Spondyloarthritis

Summary: our hypothesis is that tai chi sessions would increase physical activity of patients with spondyloarthitis. the main objective is to study the effect of tai chi sessions (16 vs.0) on global physical activity of spondyloarthitis patients, compared to a control group without tai chi.

selection and inclusion of patients will be done by principal investigator of rheumatology department. after verification of inclusion and non-inclusion criteria by principal investigator and signature of consent, patients will be randomized by 1: 1 randomization (centralized randomization by statistician into 2 groups at m0). they will participate in sessions in a deferred manner due to two per week for each group: * interventional "a" group: 32 sessions (on average 2/week) performed from m0 to m4 in 15 patients. * control "b" group: 16 sessions (on average 2/week) performed from m2 to m4 in 15 patients. patients of "b" group will be not performing sessions with "a" group patients. sessions lasting about 45 minutes will be proposed from monday to friday in a room planned from this activity within the chu. exercises will be adapted and personalized according to each one. evaluations will be carried out at m0, m2 and at the end of the protocol at m4. assessment of pain and stress will be done before and after each session. final assessment will be done at 4 months after randomization. fitness assessment and tai chi sessions will be conducted by apa student.

Eligibility criteria:
inclusion criteria: * patient age \> 18 years old with spondyloarthitis (asas criteria), with activity deemed stable by rheumatologist. * patient able to walk without help * patient able to complete a questionnaire * patient giving informed consent. * patient covered by social security exclusion criteria: * patient with disorder of higher mental function or psychiatric disorders. * patient who has previously contribute to a tai chi program. * patient with an absolute contraindication to physical activity. * protected populations: pregnant women, breastfeeding women, tutorship, trusteeship, deprived of liberty, safeguard of justice

Keywords: spondyloarthitis tai chi chuan physical activity
studying first line treatment of chronic myeloid leukemia (cml) in a real-world setting

Conditions: Chronic Myeloid Leukemia

Summary: the purpose of this study is to better understand the use of tyrosine kinase inhibitors (tki) in patients newly diagnosed with cml and their quality of life in a real-world setting.

time perspective : most patients are expected to be a mix of retrospective and prospective data collection. patients can be enrolled after their study index date (retrospective component) and have to be followed until 5 years from study index date are complete (time between enrollment and 5 year follow-up is the prospective component)

Eligibility criteria:
inclusion criteria: * newly-diagnosed chronic phase chronic myeloid leukemia (cp-cml) patients who started their first-line tyrosine kinase inhibitor (tki) treatment on imatinib, dasatinib or nilotinib in accordance with the timelines below * 18 years or older at time of of cp-cml diagnosis a) imatinib cohorts * patients who started their first-line imatinib treatment between january 2, 2008 and september 30, 2010.patients fitting this criterion are defined as retrospective imatinib patients * patients who started their first-line imatinib treatment on or after october 1, 2010 b) dasatinib cohort * patients who started their first-line dasatinib treatment after the drug was approved in this indication c) nilotinib cohort * patients who started their first-line nilotinib treatment after the drug was approved in this indication * patients are also eligible when they have already switched to a subsequent therapy (tki or other) at the time of enrollment, as long as their first-line and subsequent cml treatment information is available at site for data entry into the study electronic case report form (ecrf) * receiving treatment at medical practice (eg. community-based, office-based, hospital-based, academic setting, oncology center) exclusion criteria: * patients who are participating in an interventional trial which may influence the management of their cml disease will be excluded discontinuation criteria: * enrolled patients who join an interventional trial which may influence the management of their cml disease will be excluded at the time of entry into the interventional trial

Keywords: chronic phase - chronic myeloid leukemia
inadvertent hypothermia or hyperthermia in pediatric radiotherapy practices under anesthesia

Conditions: Hypothermia; Anesthesia; Hyperthermia, Anesthesia Related; Radiotherapy Side Effect; Childhood Cancer

Summary: in prospective, observational cohort study, changes in body temperature will be investigated before the procedure and during recovery in radiotherapy patients aged 0-18 years who need sedation due to childhood malignancies. the aims of this study were to measure the incidence and magnitude of changes in body temperature in children undergoing sedation or general anesthesia for radiotherapy, and to determine their effects on the recovery process.


Eligibility criteria:
inclusion criteria: * patients undergoing radiotherapy under anesthesia exclusion criteria: * family refusal to participate, * chronic nausea and vomiting complaints, * active infection, * apnea history, * cardiac disease, kidney and liver failure, * anomalies that may cause difficult airway, * metabolic diseases, * neurological or muscular diseases.

Keywords: hypothermia; anesthesia hyperthermia, anesthesia related radiotherapy side effect childhood cancer
phase iii randomized study of the effect of postmenopausal estrogen replacement therapy on alveolar bone loss

Conditions: Osteoporosis

Summary: objectives: i. quantify periodontal alveolar bone loss rates in postmenopausal women. ii. evaluate the effects of estrogen on alveolar bone loss rates in these patients. iii. determine whether changes in periodontal bone mass relate to bone mass changes in other skeletal sites in these patients.

protocol outline: this is a randomized, double-blind, placebo controlled study. patients are randomly assigned to receive placebo or conjugated estrogens and, if no prior hysterectomy, medroxyprogesterone. patients also receive calcium supplementation therapy daily for 3 years. participants in the placebo group may be removed from study if bone loss exceeds 5% per year. a study duration of 3 years is anticipated.

Eligibility criteria:
protocol entry criteria: * women postmenopausal for at least 2 years * at least 10 teeth for which radiographic measurements can be obtained, i.e.: not severely tilted not so closely spaced that interproximal bone is thin not in positions of restricted access

Keywords: disease-related problem/condition osteoporosis rare disease
from clinic to community: an information and communication technology (ict) home-based exercise training system for translating clinical findings

Conditions: Multiple Sclerosis; Stroke

Summary: the specific aim of the study in our example is to conduct a feasibility translational home-based exercise trial established in the leaders (r2) project with the text-me tele-exercise training system for participants with neurologic disability. we hypothesize that participants in this home-based tele-exercise training program will achieve similar gains in health and function outcomes as the onsite exercise training program. further, there will be no difference in adverse side effects (safety) between the home-based and onsite exercise treatment groups.

text-me is a home-based tele-exercise study providing a novel exercise program to participants with neurologic disabilities. the exercise curriculum is a movement 2 music (m2m) program developed during phase 2 of the grant (clinicaltrials.gov identifier nct02533882). the exercise exercise classes are taught by trained dance instructors and are composed of a set of exercises tailored to the specific needs and capabilities of adults with neurologic disability. each set of exercises is performed to high and low tempo music based on the individual's baseline level of function, with adjustments made to increase or decrease intensity if needed. the class consists of several training components: a) warmup (10 min.) to increase range of motion; strength/balance (15-20 min), aerobics (25-30 min. with rest periods as necessary); cool down (5 min). the text-me training and monitoring system is a user-centered design (ucd) involving a tele-exercise coach (e.g., a trained research staff person) interacting remotely with a participant in their home using video conferencing programs. participants wear monitors to maintain safe levels of exercise and provide feedback regarding exercise intensity to the instructors. self-reported indicators of exercise intensity are also collected using rating of perceived exertion.

Eligibility criteria:
inclusion criteria: * diagnosed with stroke * ms - mild to moderate disability (patient determined disease steps score 0-6) * able to use arms or arm/legs for exercise * ambulatory or use manual wheelchair exclusion criteria: * cognitive impairment (mini-mental state exam score \< 24) * recent weight change (+/- 25 pounds in 1 year) * poorly controlled blood pressure * cardiovascular disease event within the past six months * severe pulmonary disease * renal failure * current tobacco user or quit within the last six months * current use of medications for psychosis * active pressure ulcers
case study: hagl-lesion (hagl:humeral avulsion glenohumeral ligament)

Conditions: Shoulder Injuries and Disorders

Summary: this study shows a new technique which has been implemented at the schulthess clinic to improve the outcome after an correction of an anterior instability in the shoulder joint due to a hagl lesion.

the aim of the study is to describe and document the results of a case serie after an arthroscopically intervention to correct the anterior instability in the shoulder joint with one primary parameter (wosi-score) and several secondary parameters, which are used in the daily clinical routine (e.g.clinical examination, several questionnaires). the results of these parameters will be used to document the mid-term results (\> 1 year after surgery).

Eligibility criteria:
inclusion criteria: * arthroscopically repair of the anterior instability of the shoulder due an hagl lesion (performed by dr. m. flury, dr. h.-k. schwyzer or dr. ph. frey at the schulthess klinik) * patients ≥18 years * written informed consent exclusion criteria: * additional surgeries at the affected side after the index surgery (arthroscopically repair of the anterior instability due an hagl lesion) * non-compliance * disorders which handicap or inhibit the patient to follow the orders of the clinical testers * request of the patient

Keywords: hagl shoulder instability
preoperative prediction model of pathological outcomes (mesorectum quality and positive circumferential resection margin) in patients with mid-low rectal cancer

Conditions: Rectal Cancer

Summary: elaboration of a preoperative prediction model of the quality of the mesorectum and the involvement of the circumferential margin in patients with mid-low rectal cancer who undergo laparoscopic anterior rectal resection. in a second phase the investigators will study the utility of the prediction model in classifying patients with high risk of suboptimal quality of mesorectum and/or positive circumferential margin. patients with high preoperative risk will undergo a transanal total mesorectal excision and patients with low risk a laparoscopic transabdominal mesorectal excision. the investigators finally will compare pathological outcomes ( quality of mesorectum and circumferential margin), survival and recurrence between the two groups.


Eligibility criteria:
inclusion criteria: * patients directed to laparoscopic anterior rectal resection through a transabdominal or a transanal approach. * age ≥ 18 years * histology of adenocarcinoma or adenoma * with or without neoadjuvant chemoradiotherapy * tnm classification: t2 or t3, any n stage or m stage * intention of resection r0 exclusion criteria: * tnm classification: t1 or t4. * complicated rectal cancer or emergency surgery. * previous major colorectal surgery