Kornimate/medical-research-clean huggingface dataset:
factors related to the progression of chronic kidney disease

Conditions: Chronic Kidney Disease

Summary: chronic kidney disease is a progressive disorder that has been influenced with many factors. most of the patients has altered ca p metabolism and these dis orders are the contributing factors of the disease progression. it has been recently documented that fgf23 and klotho are the key factors of pth secretion ca-p metabolism. this study aimed to evaluate the impact of klotho and fgf23 on the progression of stage 3-4 chronic kidney disease.


Eligibility criteria:
inclusion criteria: * non-diabetic chronic kidney disease exclusion criteria: * presence of dm * actively using calcium based phosphorus binder of vitamin d

Keywords: chronic kidney disease progression fgf 23 klotho
study evaluating the effect of food on the pharmacokinetics of palovarotene and the effect of palovarotene on the pharmacokinetics of the cyp3a4 substrate midazolam in two cohorts of healthy adult subjects

Conditions: Fibrodysplasia Ossificans Progressiva

Summary: study to evaluate the effect of food and the effect of swallowing capsule whole versus sprinkling on apple sauce on the pharmacokinetics (pk)/bioavailability of palovarotene, and evaluate the effect of palovarotene on the pk of the cyp3a4 substrate midazolam.


Eligibility criteria:
key inclusion criteria: * generally healthy male or female aged 18 to 55 years, inclusive; body mass index (bmi) of 18 to 30 kg/m2 and a body weight of \>50 kg; resting pulse of \>45 bpm and \<100 bpm; systolic and diastolic blood pressure of \<140/90 mmhg key exclusion criteria: * a history or current evidence of a clinically significant or uncontrolled disease, disease or condition known to interfere with the absorption, distribution, metabolism, or excretion of drugs * exposure to synthetic oral retinoids or creams containing retinoids in the past 30 days prior to the signature of the informed consent. * history or presence of silent infections, including positive tests for human immunodeficiency virus type 1 (hiv-1), human immunodeficiency virus type 2 (hiv-2), hepatitis b virus (hbv), or hepatitis c virus (hcv) * history of allergy or hypersensitivity to retinoids, gelatin, or lactose * for the ddi component only, the subject had a history of allergy or hypersensitivity to benzodiazepines, midazolam, cherries, or midazolam formulation excipients
identifying risks of covid-19 outbreaks in work settings and the implications for control measures

Conditions: Intention to Get SARS-CoV-2 Vaccination; Intention to Get SARS-CoV-2 Antibody Test

Summary: objectives: to identify core and cross-time workplace hazards and worker's exposure prevention profile towards outbreaks in three non-healthcare work settings; to evaluate effectiveness of a theory-based educational programme on improving attitude to vaccination and virus testing in workplace; to longitudinally compare attitude of willingness to vaccination, testing of sars-cov-2 and changes of risk profile toward outbreaks among workers. design: a 5-year study comprising a randomized controlled trial (rct) and 3 parallel longitudinal studies with baseline and follow-up repeated measurements. setting: non-office, mobile and office work settings. participants: part i is a rct, 294 workers will be randomised to an intervention group (a theory-based education programme) and a control group with measurements repeated at 3rd, 6th and 9th month. part ii is a longitudinal quantitative study (i.e., prospective cohort study) involving 1,495 workers recruited at the baseline and followed up for 2 years. part iii is a longitudinal qualitative study involving 26 management and frontline workers. part iv is a longitudinal workplace hygiene study involving 6 workplaces enrolled at the baseline and followed up to conduct ventilation investigation. intervention: theory-based education intervention to build positive attitude of control measures towards sars-cov-2 outbreak. main outcome measure: workplace hygiene data (airflow, air volume, etc.); willingness to vaccination and virus tests; actual uptake of sars-cov-2 antibody testing. data analyses: multivariate regression logistic model and thematically analysed will be performed for quantitative and qualitative analysis. intention-to-treat analysis will be employed for rct. expected results: large dataset of longitudinal measurement of willingness to vaccination/testing and actual uptake will be documented to inform policy. educational intervention will be developed to mitigate risks of outbreaks in workplace.


Eligibility criteria:
inclusion criteria: * currently being employed in hong kong exclusion criteria: * who have history of physician-diagnosed cancer and sever chronic diseases

Keywords: workplace hazards exposure prevention vaccination sars-cov-2 control measures willingness attitude antibody testing
a non-pharmacological method for enhancing sleep in ptsd

Conditions: PTSD; Sleep Problems

Summary: sleep disturbance is nearly ubiquitous among individuals suffering from ptsd and is a major problem among service members returning from combat deployments. the proposed study aims to test a novel, inexpensive, and easy to use approach to improving sleep among service members with ptsd. primary outcome measures will include not only ptsd symptom improvement but also include neuroimaging of brain structure, function, connectivity, and neurochemistry changes. the proposal is firmly grounded in the emerging scientific literature regarding sleep, light exposure, brain function, anxiety, and resilience. prior evidence suggests that bright light therapy is effective for improving mood and fatigue, and our pilot data further suggest that this treatment may be effective for improving daytime sleepiness and brain functioning in brain injured individuals. thus, this intervention, in our own research and in the work of others, has been shown to affect critical sleep regulatory systems. improving sleep may be a vital component of recovery in these service members. our approach would directly address this issue. our preliminary data have shown that this approach is extremely well tolerated and is effective for improving sleep, mood, cognitive performance, and brain function among individuals with brain injuries. finally, the potential impact of this study is high because of the capability of transitioning the research to direct clinical application almost immediately. if the bright light treatment is demonstrated as effective, this approach would be readily available for nearly immediate large-scale implementation, as the devices have been widely used for years in other contexts, are already safety tested, and commercially available from several manufacturers for a very low cost. thus, the impact of this research on treating ptsd would be high and immediate.


Eligibility criteria:
* having experienced a traumatic event within the past 10 years * right handedness * 18-50 years old * primary language is english * no metal in body further eligibility will be determined through a phone screening. please call (520) 626-8591 or go to uascanlab.com to check your eligibility for this study.

Keywords: ptsd stress sleep problems brain imaging fmri
a study of the safety and efficacy of nebivolol in hypertensive patients

Conditions: Hypertension

Summary: a study to determine the safety, efficacy and superiority of nebivolol to placebo for the treatment of elevated blood pressure in patients with mild to moderate hypertension.

this study was a multi-center, multi-national, randomized, double-blind, parallel group, placebo-controlled study of nebivolol over a range of doses in patients with mild to moderate hypertension. the study consisted of 2 phases: screening/washout/single-blind placebo run-in and 2) randomization/double-blind treatment. patients had 7 scheduled clinic visits during the study.

Eligibility criteria:
inclusion criteria: * an average sitting diastolic blood pressure of greater then or equal to 95 mmhg and less then or equal to 109 mmhg at baseline exclusion criteria: * recent myocardial infarction or stroke * secondary hypertension * contraindications to beta-blocker therapy or discontinuation of prior antihypertensive agents * pregnancy, nursing or women of childbearing age not using appropriate contraception

Keywords: nebivolol hypertension beta-blockers
preoporative bevacizumab, radiation therapy, and xelox chemotherapy for locally advanced nonmetastatic rectal cancer

Conditions: Rectal Cancer

Summary: we presumed that the addition of a monoclonal antibody bevacizumab into radiation therapy and combination chemotherapy could results in improved pathologic tumor regression grade (trg) in locally advanced nonmetastatic rectal cancer.

monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. giving bevacizumab together with radiation therapy and combination chemotherapy before surgery may achieve promising improvements in pcr rates, we designed this phase ii study in patients with t3/4 or n1/2 loco-regionally advanced rectum cancer, to examine the efficacy and safety of the addition of bevacizumab to a regimen of capecitabine and oxaliplatin in combination with pre-operative radiation.

Eligibility criteria:
inclusion criteria: * histologically confirmed adenocarcinoma of the colon or rectum. * t3 or t4 adenocarcinoma or node positive colorectal tumours. * appropriate staging investigations of the primary tumour, either endorectal ultrasound or pelvic mri. * male or female aged 18 to 70. * have a performance status ecog of 0 or 1. * have a life expectancy greater than 6 months. * adequate organ function and coagulation parameters as measured by: wbc \> 4000/mm3, plt \> 100000/mm3, hb \> 10g/dl, alt \< 1.5x uln, ast \< 1.5x uln, bilirubin \< 1.5mg/dl serum creatinine \< 1.8mg/dl. * patient consent. exclusion criteria: * known to have clinical or radiological evidence of distant metastases. * evidence of intestinal obstruction (except for those after enterostomy). * patients with a past history of colorectal surgery (except for enterostomy), chemtherapy, radiation, biotherapy or targeted therapy. * pregnant woman or women of childbearing potential with a positive pregnancy test at baseline or lactating. * sexually active males and females (of childbearing potential) unwilling to practice contraception during the study. * patients with a past or current history (within last 5 years) of other malignancies, except for the indication under this study and curatively treated basal and squamous skin cancer or in-situ cancer of the cervix. * patients with mental disorder unable to complete the informed consent. * uncontrolled hypertension. * clinically significant (i.e. active) cardiovascular disease for example: cerebrovascular accidents (\<=6 months), myocardial infarction (\<= 6 months), unstable angina, new york heart association (nyha) grade ii or greater congestive heart failure, serious cardiac arrhythmia requiring medication. * moderate or serious proteinuria. * known hypersensitivity against experimental drugs.

Keywords: rectal cancer bevacizumab capecitabine oxaliplatin preoporative imrt
dual-task training in children with cerebral palsy

Conditions: Cerebral Palsy; Diplegia; Hemiplegic Cerebral Palsy; Physical Disability; Participation, Patient; Activity, Motor

Summary: there are studies investigating the dual-task effect in sitting, standing up without sitting and walking in children with spastic cp. some of these studies investigated motor-motor, some of them motor-cognitive dual-task states, and children with cp were compared to typically developing children. in all these studies, it is clearly seen that children with cp have more dual-task complexities than their typically developing peers. some of these studies draw attention to dual-task education in children with cp. however, other than a randomized controlled study and a case report in the literature, we did not find any studies investigating the effectiveness of dual-task training in children with cp. when the literature is examined in detail, there is no study that examines the effect of dual-task exercise programs on walking activities and children's participation in daily life in children with cp. this study has been planned based on this deficiency in the literature. based on icf, this study has been planned dual-task training for children with cp.


Eligibility criteria:
inclusion criteria: * being diagnosed with cerebral palsy, * having spastic type unilateral and bilateral involvement, * being between the ages of 7-18, * being gmfcss level i and level ii, * continuing normal education (not being a mainstreaming student), * not having any surgical operation involving the musculoskeletal system in the last 6 months, * not having botulinum toxin application in the last 6 months. exclusion criteria: * failing to accomplish the cognitive task (starting from a number between 0-100 and not counting back 1 each) * being a behavioral problem that makes it difficult to participate in the study, * inability to walk without support

Keywords: cerebral palsy dual-task training activity participation
evaluation of different continuous positive airway pressure (cpap) systems in patients with acute respiratory failure

Conditions: Acute Respiratory Failure

Summary: the aim of this study is to evaluate the performance, the tolerability and the efficacy on gas-exchange of different cpap (continuous positive airway pressure) systems.

three cpap systems are studied for each patient at the same level of peep: 1) continuous high-flow cpap with fixed value peep valve; 2) continuous high-flow cpap with boussignac peep valve; 3) demand flow cpap, supplied by a ventilator.

Eligibility criteria:
inclusion criteria: * intubated-tracheostomized subjects receiving cpap during the weaning from invasive mechanical ventilation exclusion criteria: * hemodynamic instability * barotrauma * severe myopathy

Keywords: cpap acute respiratory failure
laser outcomes associated with (holmium laser enucleation of the prostate) holep procedures

Conditions: Urologic Diseases; Prostate Obstruction

Summary: the primary aim is to assess the impact of laser setting frequency and wattage during holmium laser enucleation of the prostate. there is currently no gold-standard laser settings for holep procedures. in the investigator's current high-volume practice, the following settings for enucleation are: 2j 50hz. these settings are conventional settings, but there is no literature to prove optimal laser settings. the investigators hypothesizes that utilization of higher laser settings may be associated with a clinically significant (defined as \> 10%) decrease in procedural time without any detrimental postoperative outcomes, and a utilization of lower laser settings may be associated with a clinically significant (defined as \>10%) reduction in postoperative irritative voiding symptoms without any detrimental postoperative outcomes.


Eligibility criteria:
inclusion criteria: * males 18-89 who are undergoing holep for the treatment of bothersome lower urinary tract symptoms, that are typically caused by enlarged prostates exclusion criteria: * prostates measurements over 200g * patients who lack decisional capacity * patients who are non-english speakers
12 week comparison of 5 mcg and 10 mcg of tiotropium / respimat, placebo and ipratropium mdi in copd

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: the primary objective was to compare the bronchodilator efficacy of two doses (5 mcg and 10 mcg) of tiotropium inhalation solution delivered by the respimat inhaler once daily to placebo and to ipratropium bromide mdi four times daily in patients with copd. the secondary objective was to compare the safety of tiotropium inhalation solution delivered by the respimat to placebo and ipratropium bromide mdi.


Eligibility criteria:
outpatients of either sex, aged \>/= 40 years with a diagnosis of copd (fev1 \</= 60% predicted \[eccs criteria\] and fev1/fvc \</= 70%)
a comparison between biological (veritas®) vs non biological mesh (tigr®) in immediate breast reconstruction

Conditions: Breast Cancer

Summary: this study compares the outcome using a biological mesh (veritas®) compared to a non biological mesh (tigr®) in immediate breast reconstruction.

the scientific evidence using different types of mesh in breast reconstruction is low at present with very few randomized controlled studies. this study aims to compare a biological mesh (veritas®) compared to a non biological mesh (tigr®) in patients with hereditary increased risk of developing breast cancer operated with bilateral immediate breast reconstruction regarding implant loss rate,infections,total complication rate,aesthetic outcome, hqol (health related quality of life) and economics. the patients will be enrolled to the study and sign an informed consent. at the operating theater the patient is randomized either to be reconstructed with veritas® in one breast and tigr® in the other breast.. the patients will be followed up according to a specified schedule until one year postoperatively as above.

Eligibility criteria:
inclusion criteria: * patients with a confirmed breast cancer gene mutation or a calculated increased risk \> 20% of developing a breast cancer during her lifetime. exclusion criteria: * all patients that don't fulfill criteria above * previous breast surgery
comparative study of pathophysiological mechanisms and bronchial response in occupational asthma to wheat flour and quaternary ammonium compounds during standardized bronchial provocation tests

Conditions: Occupational Asthma

Summary: occupational asthma (oa) caused by high molecular weight (hmw) substances have been shown to induce predominantly an eosinophilic inflammation. in contrast, oa caused by low molecular weight (lmw) substances results in a neutrophilic inflammation. in addition, data regarding phenotype of lymphocytes in oa caused by hmw and lmw substances are scarce. the use of a new equipment will allow the realization of specific standardized bronchial challenges (bc) to occupational agents. thus, we propose to study in more detail the cellular mechanisms involved during bc to hmw and lmw occupational agents in a double-blind placebo controlled study.


Eligibility criteria:
inclusion criteria: for patients with occupational asthma to wheat flour: * clinical history, * a positive skin test to wheat flour and / or specific ige to wheat flour for patients with occupational asthma to quaternary ammonium compounds: -clinical history, for two types of asthma: * patients must have a worsening of bronchial hyperreactivity during work compared to a rest period assessed by a metacholine challenge * fev before challenge (nonspecific and specific) must be\> 70%. exclusion criteria: asthmas: * no occupational asthma: * secondary to clinically relevant sensitization to an allergen domestic * aggravated at work.
a study in asymptomatic hiv infected patients to investigate pharmacodynamics, pharmacokinetics, safety and toleration of uk-453,061

Conditions: HIV-1

Summary: a phase 2a study to investigate the effects of 7-day monotherapy of uk-453,061 on viral load response in asymptomatic human immunodeficiency virus (hiv) infected subjects, to assess the dose-response relationship, and to assess the pharmacokinetics (pk), safety and tolerability of uk-453,061 in asymptomatic hiv infected subjects.


Eligibility criteria:
inclusion criteria: * asymptomatic hiv-1 infected male and patients aged 18-55 years inclusive. * patients with virus not containing nnrti resistant mutations as determined by the vircogen virtual phenotyping essay. exclusion criteria: * patients with a cd4 count less than 250 cells/mm3. * patients whose hiv infection has been diagnosed less than 3 months prior to screening, or for whom there is evidence of recent seroconversion. * patients with an hiv viral load less than 5000 copies/ml using rt-pcr(roche amplicor v1.5).
prevalence of intrauterine adhesions after abdominal myomectomy

Conditions: Myoma;Uterus

Summary: uterine fibroids are the most common benign tumors of the genital organs of women of childbearing age. literature data show that more than 75% of women have fibroids.symptomatic fibroids account for approximately over 200,000 hysterectomies and 50,000 myomectomies annually in the united states. fibroids have a major impact on fertility, with significant adverse effect on implantation rate and spontaneous abortion rates when compared with infertile women without fibroids. the definitive treatment for uterine fibroids in a fertile patient is surgical excision. although usually effective, myomectomy is not a risk-free operation, since the surgical procedure can cause mechanical infertility and can be associated with infection, injury to adjacent tissues, hemorrhage and need to convert to hysterectomy. a not often mentioned consequence of myomectomy is post-operative intrauterine adhesion formation. it has been reported that 50% of women undergoing open myomectomy are found to have intrauterine adhesions diagnosed by hysteroscopy performed 3 months after surgery. such a high prevalence of intrauterine adhesions after open myomectomy is unexpected, however only few studies have addressed this topic. it is accepted that injury to the endometrium is generally considered to be the primary causative factor for the development of intrauterine adhesions. the reason for such a high incidence of intrauterine adhesions after open myomectomy is unclear. it is speculated that infection or in adverted closure of the uterine cavity may play a role in intrauterine adhesion formation. the relationship between the number of fibroids removed and the risk of adhesions suggests a traumatic etiology. in the preservation of the uterus for the purpose of fertility, it is essential to also understand the impact of myomectomy on the endometrium. currently no guideline recommends in office hysteroscopy as follow-up after myomectomy. the purpose of the present study is to evaluate the frequency of uterine adhesions following myomectomy and the impact of number, size and location of the fibroids as well as intraoperative breach of the endometrial cavity at the time of the myomectomy.


Eligibility criteria:
inclusion criteria: * diagnosis of one or more uterine myomas * desire to preserve fertility/uterus * myomectomy (by laparotomy, laparoscopy or robotic approach). exclusion criteria: * adults unable to consent * pregnant women * prisoners * history of previous intrauterine procedures such as dilation and curettage * history of known intrauterine adhesions * history of documented pelvic inflammatory disease * history of endometritis (acute or chronic) * hysteroscopic myomectomy

Keywords: intrauterine adhesions abdominal myomectomy hysteroscopy
relapse and failure rates between cad/cam and conventional fixed retainers

Conditions: Relapse

Summary: the aim of this study was to compare the differences in relapse and failure rates in patients treated with fixed retainers (frs) using computer-aided design/computer-aided manufacturing technology, lab-based technique, and chairside method.


Eligibility criteria:
inclusion criteria: * completion of comprehensive orthodontic treatment * class i molar and canine relationships * indication for a fixed retainer on the mandibular anterior teeth. * no extractions done as part of their treatment. * treatment with preadjusted edgewise appliance. exclusion criteria: * refusal to participate * refusal to have fixed retainers * poor oral hygiene * non-compliance
study evaluating bifeprunox in bipolar depression

Conditions: Depression Bipolar

Summary: the purpose of the study is to investigate whether eight weeks of treatment with flexible doses of bifeprunox is superior to treatment with placebo in depressed patients with bipolar disorder.


Eligibility criteria:
inclusion criteria: * men and women 18 to 65 years of age, inclusive. * diagnosis of bipolar disorder and must be experiencing a depressive episode. exclusion criteria: * this is a follow on study to protocol 3168a2-304. only subjects who have participated in the previous study are eligible.