Kornimate/medical-research-clean huggingface dataset:
prospective, monocentric, interventional study on spontaneous vaginal clearance of mycoplasma genitalium

Conditions: Mycoplasma Genitalium Infection

Summary: it is a prospective, monocentric, interventional study on spontaneous vaginal clearance of mycoplasma genitalium. the main objective is to evaluate the spontaneous vaginal clearance of m. genitalium in patients coming to perform a voluntary termination of pregnancy at the university hospital of bordeaux at 9 weeks after a vaginal sample positive for m. genitalium

mycoplasma genitalium is a bacterium that colonizes female genital tract and can be responsible for sexually transmitted infection . m. genitalium can cause cervicitis and more rarely high genital infections. in the vast majority of cases, presence of m. genitalium is not accompanied by any symptoms and women do not develop disease. natural history of m. genitalium infection is not well documented. some studies have shown a natural clearance of infection in women. the published work mainly concerns patients at very high risk of sexually transmitted disease, but we do not have french data. we propose to study the natural clearance of m. genitalium infection in patients consulting at the orthogeny centre of the university hospital of bordeaux. results of this work will allow us to have a better knowledge of the natural history of m. genitalium infection.

Eligibility criteria:
inclusion criteria: * patient selected during the first consultation, pre-abortion, and having a vaginal swab positive to m. genitalium. * patient hospitalized for an abortion at the university hospital of bordeaux. * an affiliated patient or beneficiary of a social security system. * signing free and informed consent. exclusion criteria: * patient with vaginal co-infection with c. trachomatis. * patient with symptoms of high genital infection. * taking fluoroquinolones, macrolides or tetracyclines within 21 days of inclusion. * patient under legal protection.

Keywords: mycoplasma genitalium abortion clearance ist
pressure dependent tracheal obstruction in copd patients

Conditions: Tracheobronchomalacia

Summary: background. do pressure dependent tracheal obstructions (pdto) often seen during bronchoscopy in copd patients affect pulmonary function tests and breathing symptoms? method. model study. a garden hose was compressed from one side to simulate the posterior wall of the trachea bulging into the lumen. for two obstruction lengths - 3 cm and 12 cm, the hose was increasingly compressed in eight steps. resistance was measured at each step for airflows 1 l/s through 9 l/s, and digital photos of the luminal area were taken which were used by a computer to estimate the cross sectional area reduction and the corresponding distance between the bulging (posterior)and the opposite (anterior) wall (ap-distance). patient study. 104 stable copd patients studied by pulmonary function tests and bronchoscopy. the tracheal obstruction was observed during forced expiration and cough, and the cross sectional area reduction was estimated using the results from the model study.


Eligibility criteria:
inclusion criteria: * copd exclusion criteria: * clinical evidence of malignant disease * not able to be subjected to bronchoscopy

Keywords: copd airway obstruction tracheobronchomalacia
a multiple-dose safety study of fixed combination of acetaminophen/naproxen sodium in adolescents with orthodontic pain

Conditions: Orthodontic Pain

Summary: the purpose of this study is to evaluate the safety of a fixed combination of acetaminophen/naproxen sodium when administered as multiple doses over a period of up to 10 days in adolescents 12 to below 17 years of age with post-procedure orthodontic pain.


Eligibility criteria:
inclusion criteria: * weigh 72 pounds or greater and have a body mass index (bmi)-for-age between the 5th and 95th percentile (inclusive) at screening * have undergone an orthodontic procedure within 4 hours prior to baseline (enrollment) visit * females of childbearing potential and males agree to the contraceptive requirements of study exclusion criteria: * are female and are pregnant, breastfeeding, or trying to become pregnant or male with a pregnant partner or a partner currently trying to become pregnant * have a positive urine drug test on screening or enrollment * are not able to swallow whole tablets or capsules * arrive at the site on the day of enrollment with motion sickness and/or have a history of frequent motion sickness (car sickness) in the past year, which in the judgement of the investigator is likely to confound assessment of adverse events * routinely use oral analgesics greater than or equal to (\>=) 5 times per week * have a known allergy or hypersensitivity to naproxen (or other nonsteroidal anti-inflammatory drugs including aspirin) or acetaminophen or have asthma * have presence or a history of major medical condition that in the investigator's opinion may jeopardize the participant's safety or wellbeing or the integrity of the study * have a history of chronic use of tranquilizers, alcohol, tobacco/vaping, or substance abuse, as judged by the investigator site staff, in the last year * have a history of endoscopically documented peptic ulcer disease or bleeding disorder in the last two years * have a diagnosis of gastroesophageal reflux disorder, or experienced frequent heartburn in the past year
venous function in cardiovascular disease patients

Conditions: Myocardial Infarction

Summary: the primary aim is to determine the acute effect of two different training interventions on venous plasticity in patients with myocardial infarction (mi), revascularization or coronary artery graft surgery compared to age-matched healthy subjects.

compare the effect of 4 x 4 minutes at 90 - 95 % of peak heart rate separated with 3 minutes at 70 % of peaks heart rate and moderate continuous exercise at 70 % of peak heart rate on venous function.

Eligibility criteria:
inclusion criteria: * myocardial infraction (mi) * revascularization (pci) * coronary artery bypass graft surgery (cabg) exclusion criteria: * unstable angina pectoris * uncontrolled hypertension * orthopedic and/or neurological limitations * participation in other studies * mi (closer than 4 weeks)

Keywords: coronary artery bypass exercise therapy revascularization (pci)
laughter yoga on blood glucose levels, disease perception and perceived stress level

Conditions: Diabetes Mellitus, Type 2

Summary: aim this study was conducted to evaluate the effect of laughter yoga on blood glucose level, disease perception and perceived stress level in patients with type 2 diabetes mellitus. method the study was conducted using a randomized controlled experimental design with a pre-test and post-test. the population of the study was followed up with the diagnosis of type 2 diabetes mellitus (t2dm) in the endocrine outpatient clinics of a hospital in the western region of turkey. the sample consisted of 100 patients (laughter yoga group=50, control group=50) determined by power analysis. participants were assigned to each group through a process of simple randomization. data collection was facilitated using a "patient identification form,", "the brief disease perception scale," and " the perceived stress scale".

during the research process, in the laughter yoga group participated in eight laughter yoga sessions. while the patients in the control group continued to receive routine care practices.

Eligibility criteria:
inclusion criteria: * diagnosed with t2dm for at least 6 months, * able to use computer and/or mobile applications, * at least primary education graduate, * using oral antidiabetic drugs, * no diagnosed psychiatric illness, * no communication problems, * patients who volunteered to participate in the study were included. exclusion criteria: * using parenteral insulin, * the one who doesn't attend all the yoga sessions, * patients with physical conditions that prevent them from participating in laughter yoga sessions (respiratory distress, persistent cough, veritgo, severe heart disease, hemeroid, hernia of any kind, severe back pain, urinary incontinence, epilepsy, bleeding tendency, thrombocytopenia and deformity visible on examination), * patients taking medication or other nonpharmacological methods to reduce stress, * patients who did not want to participate in the study were excluded.

Keywords: blood glucose diabetes mellitus laughter yoga nursing stress
evaluating intercostobrachial nerve block's effect on pain control after shoulder replacement

Conditions: Postoperative Pain, Acute; Shoulder Pain

Summary: interscalene blocks are frequently performed to decrease postoperative pain after shoulder surgeries and are considered the gold standard for pain control after this type of surgery. some patients report pain in the axilla (armpit) following shoulder replacement surgeries. sensation in the axilla is supplied by nerves not covered by the interscalene block. sensation in the axilla can be decreased by performing an intercostobrachial nerve block. this study aims to study whether adding an intercostobrachial nerve block to the interscalene block decreases recovery room stay time, opioid pain medication requirement, and postoperative pain scores.


Eligibility criteria:
inclusion criteria: * adult patients 18-80 years old * adult patient's bmi \<= 35 * individuals presenting for primary total shoulder arthroplasty or reverse total shoulder arthroplasty * anticipated discharge home same day of surgery * patient is able to provide informed consent to participate in the study. exclusion criteria: * patient presenting for revision shoulder surgery * allergy to amide local anesthetic, liposomal bupivacaine or other medication involving liposomal formulation * preexisting neurological deficits involving or potentially involving the ipsilateral brachial plexus * preexisting contralateral vocal fold paralysis or recurrent laryngeal paralysis * psychiatric or cognitive disorders that could interfere with perioperative evaluation including drug or alcohol abuse * chronic pain conditions * preoperative opioid use * moderate to severe pulmonary disease * moderate to severe sleep apnea * planned postoperative admission. * unplanned postoperative admission * any contraindication to interscalene or intercostobrachial nerve block including any local disorder of the skin where blockade is to be performed which would prevent safe performance of the block * any coagulation abnormality which would be a contraindication for block placement * preoperative chronic renal dysfunction requiring renal replacement therapy or crcl \< 60 * sulfa allergy (or other reason patient cannot receive celecoxib) * allergy or intolerance to any medication in the protocol * body mass index \>35 * pregnancy * incarceration * asa classification greater than 3 * inability to provide informed consent * refusal to participate in the study
the relationship between activity energy expenditure and body composition in school-age children

Conditions: Childhood Obesity

Summary: obesity is increasing rapidly all over the world not only in adults but also among children. as a modifiable component of total energy expenditure (tee) ,the amount of energy expended during physical activity plays an important role in preventing weight gain. decreased physical activity, coupled with an over-consumption of calories, lead to the change of body composition by storing energy as fat.although several studies have simultaneously examined body composition with energy expenditure the independent roles of body composition with activity energy expenditure (aee) are less firmly established. it's suspected shrewdly that energy expenditure is partly influenced by the body composition. the aim of the study is to examine the relation of aee with body composition in a population of school-age children.

body composition (ie. fat% and ffm) will be evaluated by means of bioelectrical impedance analysis (bia) with inbody 720 (biospace, seoul, south korea). anthropometric dimensions will be recorded for all participants according to standard procedures. height will be recorded to the nearest 1.0mm by using a field stadiometer (seca corporation, germany). fitmate metabolic system (cosmed, rome, italy) will be used to estimate aee. subjects will be tested in a 10-minute submaximal exercise test using the fitmate systems while taking cycling test at 50 watts on an electrically braked bicycle ergometer. each subject will be connected to a calibrated respiratory gas analyzer, a portable metabolic analyzer designed for measurement of oxygen consumption during exercise via a face mask. heart rate will be simultaneously measured with the use of a cosmed wireless hr monitor to track the participant's heart rate level.

Eligibility criteria:
inclusion criteria: * children in shanghai exclusion criteria: * cardiovascular disease * asthma * severe disease conditions such as cancer and renal failure * taking steroids (corticosteroids) or antidepressants

Keywords: activity energy expenditure body composition
changes in perioperative blood volume and fluid distribution in patients undergoing primary total hip replacement.

Conditions: Hip Arthroplasty Replacement

Summary: clinical assessment of bleeding and calculation of perioperative blood loss do not provide an accurate estimate of blood volume. this makes rational fluid management difficult, which is of high importance for patient-related outcomes. the availability of carbon monoxide(co)-rebreathing allows for simple, non-invasive and precise measurement of changes in blood volume. the purpose of the study is to investigate and describe changes in blood volume and fluid distribution perioperative in patients undergoing total hip arthroplasty. furthermore, to investigate the association between changes in blood volume and incidence of orthostatic insufficiency.


Eligibility criteria:
inclusion criteria: * patients scheduled for an elective total hip arthoplasty (tha) in a standardized fast track setting. * capable of participating in co-rebreathing measurement * age ≥ 18 years * able to speak and understand danish * has provided written informed consent. exclusion criteria: * intraoperative blood loss exceeding 750 ml. * perioperative need for a blood transfusion. * confirmed or suspected coagulopathies. * factors that make co-rebreathing measurement impossible. * known orthostatic intolerance. * american society of anesthesiologists physical status (asa) classification ≥ 4.

Keywords: blood loss blood volume
dextroamphetamine-cocaine behavioral intervention - 5

Conditions: Cocaine-Related Disorders

Summary: the purpose of this study is to examine dextroamphetamine-cocaine behavioral intervention in cocaine dependent patients.


Eligibility criteria:
please contact site for information.

Keywords: cocaine dependence
offering support and electronic resources for care partners of those with multiple sclerosis

Conditions: Multiple Sclerosis; Caregivers

Summary: this study is an enhancement of the fatigue management programs for people with ms study (nct03550170). the purpose of this randomized clinical trial is to test the effectiveness of two interventions delivered remotely to support unpaid caregivers (uc) of people with multiple sclerosis (ms). we hypothesize that a high resource intervention will be significantly better than a lower resource intervention in terms of the primary outcome (uc anxiety, depression, and stress) and secondary outcome (covid specific anxiety).

ucs are often caring for persons with chronic disabling conditions, who are at higher risk for severe covid-19 illness. this presents incredibly stressful situations for ucs, which can result in depression, anxiety, and worse health outcomes both for them and their care recipients. until a vaccine becomes available, these demands will force ucs to provide more support, whether in-person or remotely, for persons with ms. the aim of this study is to compare 2 modes of supporting ucs of people with ms. we will compare the effectiveness of a high resource highly tailored intervention that includes tele-coaching intervention (delivered via videoconference or phone) + web site information to a low-resource web-site only intervention. our primary outcomes are uc anxiety, depression, and stress (dass-42 scale) and a secondary outcome is covid specific anxiety (cas scale). these 2 interventions were selected because they will inform administrators and clinicians on whether a resource-intensive or a low-resource intervention is needed to yield meaningful outcomes. the comparison will also help uc decide how they should spend their limited time. these interventions are relevant to ucs of people with ms because of their need for tailored information provided in flexible ways to promote learning and support.

Eligibility criteria:
inclusion criteria: 1. an adult family member or friend (18 years of age or older) of a person with ms 2. self-identified as an unpaid caregiver for person with ms 3. access to internet 4. capable of providing informed consent in english exclusion criteria: 1. under age 18 2. cannot speak english 3. unable to provide consent 4. no access to the internet
does the understanding of placebo mechanisms compensate for the loss of efficacy associated with open label placebo

Conditions: Acute Pain

Summary: the investigators are investigating whether, when given detailed information about underlying placebo mechanisms and pain, subjects will have a response similar to that of those subjected to a procedure in which they receive a conventional placebo treatment (associated with deception). study design: this is a non-inferior parallel, controlled and randomized, single blind trial. population: the investigators will include in the study 126 subjects without known pathology. participants will then be divided into 2 groups on a randomized basis. methodology: each subject will undergo three sessions of cold pressure test (cpt), a cold pain stimulation method: calibration, condition of interest (conventional placebo or educated placebo) and control. the investigators' main judgment criterion is be the difference in pain intensity experienced on the visual analog scale between the cpt control and the cpt under the condition of interest. this study will allow the investigators to rule on the non-inferiority of an educated open label placebo compared to a conventional placebo in the context of an acute painful stimulation.


Eligibility criteria:
inclusion criteria: * person affiliated to social security * informed consent, written and signed by the subject. exclusion criteria: * persons referred to in articles l1121-5 to l1121-8 of the public health code (csp), which corresponds to all protected persons: pregnant women, parturient women, nursing mothers, persons deprived of their liberty by judicial or administrative decision, persons subject to a legal protection measure, cannot be included in clinical trials. * persons with a pathology against indicating the use of cpt experimentally induced pain : * any pathologies affecting the venous, arterial or lymphatic system * diabetes * cardiac disorders * asthma * frostbite * epilepsy * arthritis * lupus erythematosus * allergy to cremafluid® cream * person with concomitant treatment that modifies sensitivity to pain, chronic or acute at the time of the experiment, such as analgesics, psychotropic drugs or anti-inflammatories.

Keywords: placebo experimental pain
a comparison of contact aspiration versus stent retriever for acute basilar artery occlusion

Conditions: Basilar Artery Occlusion; Endovascular Treatment

Summary: compare the effectiveness and safety of contact aspiration (ca) and stent retriever (sr) in acute ischemic stroke patients with basilar artery occlusion.


Eligibility criteria:
inclusion criteria: 1. age≥18 years; 2. acute basilar artery occlusion confirmed by cta/mra/dsa; 3. last known well to puncture time≤24 hours; 4. pc-aspects score≥6 points; 5. baseline nihss score≥10 points; 6. consent to endovascular treatment; 7. informed consent signed. clinical exclusion criteria: 1. baseline mrs≥3 points; 2. known or suspected severe basilar artery stenosis (\>70%) or chronic occlusion based on history, imaging, or clinical manifestations; 3. refractory hypertension that is difficult to be controlled by drugs (defined as persistent systolic blood pressure \>185 mmhg or diastolic blood pressure \>110 mmhg) 4. genetic or acquired hemorrhagic tendency, coagulation factor deficiency or on anticoagulant therapy and international normalized ratio (inr) \> 3.0; 5. laboratory tests: baseline blood glucose \ 400mg/dl (22.2mmol/l); baseline platelet count \<50×109/l; 6. known severe allergy (more severe than skin rash) to contrast agents uncontrolled by medications; 7. females who are pregnant, or those of childbearing, potential with positive urine or serum beta human chorionic gonadotropin test; 8. other circumstances that the investigator considers inappropriate for participation in the trial or that may pose significant risks to patients (such as inability to understand and/or follow the study procedures and/or follow up due to mental disorders, cognitive or emotional disorders). imaging exclusion criteria: 1. ct or mr evidence of acute intracranial hemorrhage (the presence of microbleeds on mri is allowed); 2. midline shift or herniation, mass effect with effacement of the ventricles; 3. complete cerebellar infarct on ct or mri with significant mass effect and compression of the 4-th ventricle; 4. complete bilateral thalamic infarction on ct or mri; 5. inability to endovascular treatment due to excessive tortuosity, variation, or dissection of the artery; 6. subjects with occlusions in both intracranial vertebral arteries; 7. subjects with occlusions in both anterior and posterior circulation; 8. evidence of intracranial tumor (except small meningioma).
the swedish birth seat trial

Conditions: Instrumental Vaginal Births; Oxytocin Augmentation for Labor; Maternal Blood Loss; Perineal Outcomes; Fetal Outcomes

Summary: the purpose of this study is to determine whether birth on a birthing seat will effect numbers of instrumentally assisted vaginal births, vaginal traumas, blood loss,use of artificial oxytocin for labour augmentation and fetal outcomes.


Eligibility criteria:
inclusion criteria: * nulliparous women who understood the swedish language sufficiently well to receive information and give informed consent * a normal pregnancy,singleton fetus in cephalic presentation * spontaneous onset of labor occurring between gestational weeks 37 + 0 and 41 + 6 * body mass index less (bmi) than thirty * gestational diabetes not requiring medical treatment * women who were planning a vaginal birth after a caesarean section (vbac) * women induced because of spontaneous rupture of membranes with no spontaneous contractions for longer than twenty-four hours exclusion criteria: * multiparous women * birth before gestational week 37 * breech presentation * maternal bmi more than 30 * multiple pregnancy * infectious disease * pre-eclampsia or other conditions requiring medical care

Keywords: birth seat childbirth instrumental delivery upright position