Kornimate/medical-research-clean huggingface dataset:
an evaluation of the biodistribution and imaging characteristics of abt-806i (111in-abt-806) in subjects with advanced solid tumor types

Conditions: Advanced Solid Tumors

Summary: this is an open label study designed to evaluate the biodistribution and imaging characteristics of abt-806i (111in-abt-806) in subjects with advanced solid tumor types.


Eligibility criteria:
inclusion criteria: * subject has a solid tumor of a type likely or known to either overexpress wild-type epidermal growth factor receptor (egfr) or to express variant iii mutant egfr (e.g., head and neck squamous cell carcinoma, non-small cell lung carcinoma (nsclc), and colorectal carcinoma). * subject must have disease that is not amenable to surgical resection or other approved therapeutic options with curative intent. * subject cannot tolerate or must not be eligible for other approved therapeutic options with known survival advantage. * subject has an eastern cooperative oncology group (ecog) performance status of 0 to 2. * subject must have measurable disease as defined by response evaluation criteria in solid tumors (recist) version 1.1 with at least 1 extrahepatic 2 cm lesion. exclusion criteria: * subject has received anticancer therapy including chemotherapy, immunotherapy, radiotherapy, hormonal, biologic, or any investigational therapy within a period of 14 days prior to the first dose of abt-806i. * subject has received a prior egfr-directed monoclonal antibody within a period of 4 weeks prior to the first dose of abt-806i. * subject has unresolved clinically significant toxicities from prior anticancer therapy, defined as any common terminology criteria for adverse events (ctcae) grade 2 or higher. * subject has had major surgery within 21 days prior to the first dose of abt-806i. * subject has a clinically significant uncontrolled condition(s) including but not limited to the following: * active uncontrolled infection * symptomatic congestive heart failure * unstable angina pectoris or cardiac arrhythmia * psychiatric illness/social situation that would limit compliance with the study requirements
developing a discrimination model to diagnose als

Conditions: Amyotrophic Lateral Sclerosis

Summary: to combine several brain imaging techniques to develop a new diagnostic test to help with earlier diagnosis of amyotrophic lateral sclerosis.

early diagnosis and lack of understanding of the pathophysiology of als remain a significant obstacle to making a timely intervention to help patients suffering from this fatal disease. we envision a future in which neuroimaging techniques will be a critical tool in the diagnostic work-up of als. advanced neuroimaging techniques offer great potential in identifying central nervous system metabolite and cellular alterations in als. we propose an innovative approach to combine complementary advanced mri techniques to interrogate brain chemistry (mrs), brain microstructure (dti) and brain function (fcmri) and develop a clinically relevant discriminatory disease model.

Eligibility criteria:
inclusion criteria: 1. 18 years of age or older 2. subjects with als (amyotrophic lateral sclerosis) 3. healthy subjects - exclusion criteria: 1. active substance abuse 2. has co-morbid psychiatric disease 3. has opportunistic cns (central nervous system) infection 4. has a history of head injury 5. has a contraindication for mri (e.g. cardiac pacemaker, ferromagnetic or metallic implants) 6. pregnant
effect of enhanced recovery after surgery(eras) after liver resection for primary liver cancer

Conditions: Carcinoma, Hepatocellular

Summary: the purpose of this study is to evaluate enhanced recovery after surgery(eras) protocol versus conventional treatment on patients who underwent liver resection for hepatocellular carcinoma(hcc).

212 patients are randomly recruited from inpatients of shanghai zhongshan hospital, eastern hepatobiliary surgery hospital, renji hospital, anhui provincial hospital, subei people's hospital of jiangsu province and affiliated tumor hospital of nantong university from february 2016 to july 2016. randomly assigned about half of the patients to receive enhanced recovery after surgery(eras) protocol and the other half to receive conventional treatment. evaluate the safety and efficacy of the eras protocol.

Eligibility criteria:
inclusion criteria: * diagnosed with hcc with indications for surgery * without any surgical contraindications * under went open liver resection * operation ranges less than 4 hepatic segments * informed consent exclusion criteria: * not suitable for surgery * benign lesions or other lesions proved by pathology * surgical procedure changed during operation or combined evisceration * refused to participate or drop out

Keywords: enhanced recovery after surgery hepatocellular carcinoma
determination of longus colli muscle thickness by ultrasonography

Conditions: Pain Syndrome; Pain, Intractable; Complex Regional Pain Syndromes; Hyperhidrosis

Summary: this study aims to assess the longus colli muscle thickness by ultrasonography in order to guide stellate ganglion blocks

stellate ganglion block is an interventional pain management procedure that is often performed for diagnostic and therapeutic purposes. it has long been performed with the guidance of fluoroscopy, and despite the increasing use of ultrasonography in recent years, fluoroscopy is still the gold standard method. in traditional fluoroscopic method, the needle is directed to the transverse process of the c6 vertebra, after touching the anterior tubercle (chassaignac's tubercule) the needle is slightly withdrawn and following a negative aspiration, injection is performed. the ideal placement of the needle should be anterolateral to the longus colli muscle and deep to the prevertebral fascia. further placement may cause intramuscular spread and superficial placement may cause injection in the carotid sheath or vascular structures. these are the most important reasons for clinical ineffectiveness. how far should the needle be withdrawn? data is inconsistent in the literature. the primary aim of this study is to determine the distance from transverse process to longus colli muscles anterior border and from transverse process to carotid sheath's posterior border. secondary aim is to investigate the relationship between longus colli muscle thickness and age, gender, height, weight, bmi and neck circumference.

Eligibility criteria:
inclusion criteria: * age between 18 - 65 years, * giving informed consent for examination, ultrasonographic evaluation and study participation exclusion criteria: * having a chronic neck pain for more than 6 months, * having any neurological or musculoskeletal conditions that may affect the anatomy of cervical region (cervical disc herniation, torticollis, severe scoliosis, vertebral malformation, spinal stenosis, myopathies, etc.) * having a history of surgery or radiation therapy in the cervical region

Keywords: stellate ganglion longus colli muscle ultrasound
interest of immersive virtual reality on stress during botulinum toxin injections in spasticity (rvtox)

Conditions: Central Neurogical Impairment

Summary: the main objective of the study is to investigate the effect of exposure to a virtual reality session during botulinum toxin injections on injection-induced stress. the secondary objectives are to study the effect of exposure to a virtual reality session during botulinum toxin injections, on the pain induced by the injection. and study the evolution of the effects of virtual reality with the repetition of the sessions.

botulinum toxin injections is very frequently used in the treatment of spasticity after central neurological damage (stroke, multiple sclerosis, spinal cord injury, head trauma). the injections may be painful and the tolerance of the injections varies from one patient to another. the pain felt during the injection causes in most patients great stress during the injection. virtual reality is a video technique with 360 ° vision simulating the physical presence of the patient in an "existing" environment outside the hospital setting. this technique has been used in painful procedures but only one publication, in pediatrics, has shown a decrease in pain and agitation during botulinum toxin injections. the hypothesis of this research is that an immersive virtual reality system can, in adults, reduce stress and the painful experience of botulinum toxin injections.

Eligibility criteria:
inclusion criteria: * adult patient, male or female, suffering from spasticity of neurological origin (multiple sclerosis, stroke, head trauma, etc.) and eligible for treatment by botulinum toxin injection * able to give an informed consent to participate in research * affiliation to social security. exclusion criteria: * contraindication to virtual reality (epilepsy, schizophrenia, strabismus, amblyopia, anisometropia, local contraindication to wearing a helmet (lesion of the face or the skull) * major cognitive disorders * any medical condition deemed by the investigator to be incompatible with the research. * indication of sedation by meopa during botulinum toxin injection sessions. * patients who have already experienced virtual reality * drug treatment or medical condition that may affect heart rate variability * pregnant or breastfeeding women * patients under safeguard of justice * refusal of participation.

Keywords: central neurological impairment (stroke, multiple sclerosis) virtual reality mask spasticity botulinum toxin injections stress pain
effect of an oral absorbent ast-120 in late-stage chronic kidney disease (ckd) patients.

Conditions: Chronic Kidney Disease; AST-120

Summary: recent research work has directed especial attention toward a distinct group of uremic retension molecules, called "protein-bound uremic toxins". the prototypes of this group of uremic toxins are indoxyl sulfate and p-cresol. these uremic toxins can promote production of free radical and impair antioxidant system and exerts direct toxicity on different cells and organs, including mesangial, tubular, endothelial cell and osteoblasts. accumulation of these protein bound uremic toxins results in glomerular sclerosis and interstitial fibrosis of kidneys of uremic rats and confer skeletal resistance to parthyroid hormone in uremic patients. in hemodialysis, high serum p-cresol level is associated with higher cardiovascular mortality. ast-120 (kremezin) is a carbonated oral absorbent extensively used in japan and korea. it has superior adsorption ability for certain small-molecular weight organic compounds known to accumulate in patients with ckd. in uremic rats and ckd patients, oral administration of ast-120 decreased the elevated pretreatment levels of serum indoxyl sulfate. in japan, it was reported that ast-120 suppressed the increase in serum creatinine levels, prevented proteinuria, improved uremic symptoms, and, consequently, led to the postponement of dialysis therapy. value of ast-120 on the outcome of late-stage ckd patients is still unknown. we hypothesized ast-120 through reduction of level of indoxyl sulfate and p-cresol can improved the morbidity- mortality of ckd patients. the principal aim of this prospective cohort study is to investigate the effectiveness of ast-120 in incidence of dialysis and mortality of late-stage ckd patients. determination of this relationship can help to establish new therapeutic strategy in the treatment of late-stage ckd patients.


Eligibility criteria:
inclusion criteria: * adults aged \> 18 year-old or \< 85 year-old * egfr or ccr \< 60 ml/min * hemoglobin \ 200 ng/dl and transferrin saturation \> 20%) * no spontaneous renal improvement or progression in past 3 months. exclusion criteria: * renal transplant recipients, liver cirrhosis, bone marrow disorder * blood pressure \> 170/80 mmhg in 3 occasions * recent cardiovascular disease (coronary artery disease, myocardial ischemia, cerebrovascular disease or peripheral artery disease) or gastrointestinal bleeding in past 3 months * acute tubular necrosis in the past 3 months * unwilling to participate in the trial
bioavailability of the fixed combination of amodiaquine and artesunate under fed & fasted conditions

Conditions: Malaria

Summary: * primary objective: to evaluate the interaction with food after a single oral dose of a fixed combination of amodiaquine (aq) and artesunate (as) (coarsucam™) in healthy male subjects * secondary objective: to assess the clinical and biological safety and tolerability of coarsucam™


Eligibility criteria:
inclusion criteria: * healthy caucasian subjects * weight between 50 kg and 90 kg. 18 ≤ body mass index ≤ 28 kg/m2. the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
study of treatment's echocardiographic mechanisms

Conditions: Sepsis

Summary: this ancillary study determines whether the crystalloid liberal or vasopressors early resuscitation in sepsis (clovers) \[clinicaltrials.gov identifier: nct03434028\] treatment arms (restrictive fluids strategy vs. liberal fluid strategy) for early sepsis-induced hypotension are associated with differences in cardiac structure and function based on an echocardiogram at 24 hours after randomization. secondarily, this ancillary study explores possible heterogeneity of treatment effect based on an echocardiogram performed shortly after randomization in clovers.

the crystalloid liberal or vasopressors early resuscitation in sepsis: study of treatment's echocardiographic mechanisms (clovers-stem) study is an ancillary study to clovers, a parent multi-center, prospective, phase 3 randomized non-blinded interventional trial of fluid treatment strategies in the first 24 hours for patients with sepsis-induced hypotension. the clovers trial attempts to determine the impact of a restrictive fluids strategy (vasopressors first followed by rescue fluids) as compared to a liberal fluid strategy (fluids first followed by rescue vasopressors) on 90-day in-hospital mortality in patients with sepsis-induced hypotension. this ancillary study obtains echocardiograms among clovers-enrolled patients who consent to clovers-stem at baseline and 24 hours later (secondarily, this study also measures serum troponin levels at baseline and 24 hours) to pursue three aims: 1. evaluate for differences in left ventricular global longitudinal strain at 24 hours after randomization between treatment arms; 2. evaluate for differences in right ventricular end diastolic area to left ventricular end diastolic area ratio at 24 hours after randomization between treatment arms; 3. explore possible heterogeneity of treatment effect based on baseline echocardiogram.

Eligibility criteria:
inclusion criteria: * enrolled in the crystalloid liberal or vasopressors early resuscitation in sepsis (clovers) trial exclusion criteria: * lack of informed consent for this ancillary study * allergy to ultrasound-enhancing agents

Keywords: fluid management sepsis-induced hypotension vasopressors cardiac contractility
ns-089/ncnp-02-201 in boys with duchenne muscular dystrophy (dmd)

Conditions: Duchenne Muscular Dystrophy

Summary: this is a phase 2, open-label, multi-center, 2-part study of ns-089/ncnp-02 administered by weekly iv infusion to ambulant boys aged ≥4 to \<15 years with dmd due to mutations amenable to exon 44 skipping. participants will receive a selected dose of ns-089/ncnp-02 administered once weekly. the study consists of 2 parts: part 1 and part 2. six participants (cohort 1) will participate in both part 1 and part 2, and 14 participants (cohort 2) will be added for part 2.


Eligibility criteria:
inclusion criteria: * male ≥ 4 years and \<15 years of age * confirmed dmd mutation(s) in the dystrophin gene that is amenable to skipping of exon 44 to restore the dystrophin mrna reading frame * able to walk independently without assistive devices * ability to complete the ttstand without assistance in \<20 seconds * stable dose of glucocorticoid for at least 3 months and the dose is expected to remain on a stable dose for the duration of the study. * other inclusion criteria may apply. exclusion criteria: * has a body weight of \<20 kg at the time of informed consent (applies to participants screening for part 1 only) * evidence of symptomatic cardiomyopathy * current or previous treatment with anabolic steroids (e.g., oxandrolone) or products containing resveratrol or adenosine triphosphate within 3 months prior to first dose of study drug * current or previous treatment with any other investigational drug within 3 months prior to the first dose of study drug or within 5 times the half-life of a medication, whichever is longer * surgery within the 3 months prior to the first dose of study drug or planned during the study duration * previously treated in an interventional study of ns-089/ncnp-02 * having taken any gene therapy. * having received exon skipping oligonucleotide within 1 year prior to the first dose of ip or is expected to receive exon skipping oligonucleotide prior to completion of study. * other exclusion criteria may apply.
citizen action for sustainable dengue control in sub-saharan africa

Conditions: Dengue

Summary: this project focuses on addressing arboviral outbreaks in ivory coast by involving local communities in the sustainable control of aedes mosquitoes, utilizing scientific advice and environmental interventions. it will evaluate the impact of a participatory strategy on decreasing mosquito populations and the risk of virus transmission, aiming to provide insights for policy development on disease prevention.

this project targets the growing threat of aedes mosquito-borne diseases such as dengue in africa, focusing on the anono and gbagba communities in abidjan, ivory coast, by transitioning from traditional control approaches to a community-driven strategy. it focuses on educating and involving communities in the design of sustainable mosquito management measures, such as breeding site eradication and adult mosquito capturing, with scientific experts guiding the efforts. the approach will entail conducting sociocultural surveys and interactive workshops while also encouraging local participation and multi-sectoral collaboration. a randomized controlled trial (rct) will test this effectiveness of this novel integrated community-based participatory intervention approach in reducing the transmission of aedes mosquito and other arboviruses. this effort seeks to develop a scalable model for arboviral disease control, promote community resilience, and inform policy recommendations for better public health outcomes in resource-constrained urban settings.

Eligibility criteria:
inclusion criteria: 1. geographical location: households must be located within the designated clusters in the two districts involved in the trial. 2. participation in cluster arms: households must belong to a cluster that is assigned to one of the four arms (1. control, 2. community-based larval source management, 3 enhanced aedes adults trapping (bg-gat), 4. enhanced aedes adults trapping (bg-gat) + community-based larval source management). 3. willingness to participate: households agreed to allow researchers to place mosquito traps and conduct larval and adult mosquito surveys. 4. socio-environmental data: households must agree and provide consent to participate to the socio-environmental questionnaire. exclusion criteria: 1. outside of trial clusters: households located outside the designated clusters in the two districts were excluded. 2. refusal to participate: households that do not consent to mosquito trap placement or surveys 3. inaccessibility: households that are not accessible for regular visits or data collection (e.g., due to relocation or difficult terrain).

Keywords: aedes aegypti vector control community based intervention participatory research dengue africa ivory coast
surveillance of rotavirus gastroenteritis

Conditions: Gastroenteritis

Summary: * epidemiological studies have shown the diversity of resistance genotypes and the evolution of their prevalence in the paediatric population. this large study conducted in a context of very low vaccination coverage will generate more precise data on the natural epidemiological evolution of rotavirus, notably the g9 genotype, which has appeared relatively recently. * this study will allow us to identify and document rare or unusual strains of human or animal origin. the complete genetic characterization of these strains will also make it possible to study their ability to recombine and to assess the risk of emergence. among these still rare strains, the investigators are particularly monitoring g12 rotavirus, whose ability to recombine raises the risk of emergence. * for at least one of the centres taking part in the study, the paediatric population studied will be given strong vaccination coverage. it will be extremely interesting to compare the results obtained in the vaccinated population with non-vaccinated children to assess the impact of this vaccination on the distribution of rotavirus genotypes


Eligibility criteria:
inclusion criteria: * children hospitalized or consulting in one of the participating centres since january 2007 for acute gastroenteritis (age). age is defined by at least 3 soft or liquid stools or at least 3 bouts of vomiting within 24 hours or one of the following signs - diarrhoea or vomiting accompanied by at least 2 additional symptoms among diarrhoea or vomistin, abdominal pain, fever. exclusion criteria: * children older than 5 years. * children presenting chronic diarrhoea (\> 2 weeks). * children presentant immune deficiency. * children presenting nosocomial gastroenteritis. the nosocomial nature will be determined by the onset of acute diarrhoea occuring after 48 hours following admission
evaluation of physical activity of patients admitted to addiction service

Conditions: Alcoholism

Summary: addiction is a public health issue that affects nearly 30% of french people according to insee. for several years now, the investigators have known that sport is a real help in the fight against addictions, with recent medical authorization to prescribe physical activities. a study from august 2016 claims that regular physical activity may offset the harmful effects of alcohol. (1) based on the answers given by 36,370 britons between 1994 and 2006, the researchers showed the existence of a link between the practice of 150 minutes of physical activity per week and the decrease in deaths linked to consumption. alcohol. these results, compared to 18 other studies (2), reveal the benefits of physical activity in the management of addictions. but what about current practice and addictions and sports practice in general ?


Eligibility criteria:
inclusion criteria: - any patient entering the addictology service for a reason related to addiction (withdrawal, vmi, etc.) at the chu de st eloi between january 01, 2020 and may 31, 2020 aged at least 18 years old exclusion criteria: * patient whose hospitalization is not related to addictology (accommodation, medical examination, etc.) * minor patient (age \<18 years)

Keywords: psychoactive substances consumption physical activity alcohol withdrawal dependence level drug users