Kornimate/medical-research-clean huggingface dataset:
intralesional vitamin d3 versus intralesional acyclovir in treatment of plantar warts

Conditions: Plantar Wart

Summary: to evaluate and compare the efficacy and safety of intralesional acyclovir versus intralesional vitamin d3 in the treatment of plantar warts

introduction warts are common epidermal growths caused by various strains of human papillomavirus (hpv) affecting all age groups. they have an unsightly appearance and are mostly asymptomatic but sometimes may be painful as in the case of palmoplantar warts . plantar warts is a clinical variant that occur on sole of the foot, most frequently over pressure points . it is estimated that 40% of population is infected with hpv, and in 7% to 12%, a wart develops . plantar warts exhibit an annual incidence of 14% in the general population . sixty-five percent to 78% of cutaneous warts have been shown to regress within 2 years . in persons older than 12 years, the rate of spontaneous regression significantly decreases . variable therapeutic options are available for treating warts, with none considered a gold standard. primary treatments include topical salicylic acid, topical imiquimod, topical 5-fluorouracil, cryotherapy, excision, electrocautry and laser vaporization . vitamin d is a fat-soluble steroid prohormone that has wide range of biological actions e.g. inhibition of cellular proliferation, induction of terminal differentiation, and inhibition of angiogenesis. it also stimulates macrophages and cathelicidin production . recently, several studies have demonstrated the efficacy of intralesional vitamin d in treatment of warts, as well as recalcitrant lesions, with clearance rates of 72.5%-90% . acyclovir is a synthetic purine nucleoside analogue with activity against some viruses as herpes simplex and varicella-zoster virus. acyclovir uses viral thymidine kinase to convert to its active form, acyclovir triphosphate. through this mechanism of utilizing viral thymidine kinase, acyclovir specifically targets viral dna preventing its replication in the host. previously, few studies and case reports documented the clearance of warts, some were unresponsive to prior treatment, with both topical and oral use of acyclovir . a recent study has evaluated the efficacy of intralesional acyclovir versus intralesional saline in treatment of warts and reported complete clearance rate of 52.6% and a partial response of 16.7% for acyclovir with a statistically significant difference from saline (0% complete clearance) .

Eligibility criteria:
inclusion criteria: * adult participants of both sex with plantar warts will be included in the study exclusion criteria: * - children \< 12 years. * pregnant and lactating women. * receiving any treatment for warts within 1 month before the study. * systemic antiviral medication. * previous history of vitamin d or acyclovir hypersensitivity. * vitamin d supplementation. * concurrent other skin disorders. * immunosuppressive disorders or receiving immunosuppressive drugs. * receiving drugs that may alter vitamin d level including prednisone, orlistat, phenytoin and thiazide diuretics.
planned parenthood teen council program study

Conditions: Adolescent Problem Behavior

Summary: this is a randomized controlled trial (rct) evaluation of the teen council program that was tested with high school students (grades 10-12) to assess whether it results in a reduction of teen pregnancy among other outcomes.

over the course of five years, we expected to have approximately 800 teens (400 program and 400 control) in the study. teens were randomly selected for the program (teen council) and control (no program) conditions. teens in both groups were surveyed in the late summer/early fall of their enrollment year and each spring thereafter. participation in the evaluation by control teens and unenrolled program teens was recognized with a small stipend. the pre-survey was administered during the summer retreat for incoming teen council members. the same survey was administered by philliber staff for the control youth via online, telephone, or mailed surveys during the late summer/fall. the post-surveys were administered at the end of the school year. again, the survey was administered by program facilitators for the teen council program group. philliber administered the post survey for the control group providing the same options for completion (online, telephone, or mail). to facilitate follow-up, complete contact information was collected at baseline. this included the telephone numbers, physical addresses, and email addresses of the student and telephone numbers of their parents/guardians. also requested was contact information for two relatives or adult friends who would likely know how to contact the teen. parents were asked on the consent form to provide permission to receive change of school information in the event that their teen transferred to a new school. philliber reached out to unenrolled teen council members and control group teens by telephone, email, text messaging, and/or u.s. mail for survey administration (via telephone, online, or hard copy).

Eligibility criteria:
inclusion criteria: applicants had to be: 1. entering 10th, 11th, or 12th grades; 2. able to attend an annual mandatory overnight retreat; 3. interested in providing accurate sexual health information to peers; 4. able to commit to weekly meetings; 5. able to miss school occasionally for presentations (one day per month); 6. responsible for budgeting their time and keeping up with their academic work. exclusion criteria: any interested participant who did not meet all of the inclusion criteria: 1. was not entering 10th, 11th, or 12th grades; 2. was not able to attend an annual mandatory overnight retreat; 3. was not interested in providing accurate sexual health information to peers; 4. was not able to commit to weekly meetings; 5. was not able to miss school occasionally for presentations (one day per month); (6) was not responsible for budgeting their time and keeping up with their academic work.

Keywords: adolescent pregnancy prevention youth development
crd007 for the treatment of duchenne muscular dystrophy, becker muscular dystrophy and symptomatic carriers

Conditions: Duchenne Muscular Dystrophy; Becker Muscular Dystrophy

Summary: this is an investigation of the efficacy and safety of crd007 in duchenne muscular dystrophy (dmd), becker muscular dystrophy (bmd) and symptomatic carriers.


Eligibility criteria:
inclusion criteria: * documented diagnosis of dystrophinopathy exclusion criteria: * severe functional impairment

Keywords: dmd bmd symptomatic carriers
mobile intervention - physical activity in cancer treatment

Conditions: Carcinoma, Renal Cell

Summary: aim 1. determine the feasibility and acceptability of the proposed mobile technology intervention to increase physical activity patients receiving treatment for renal cell carcinoma. aim 2. evaluate the effect of the proposed intervention components (affective framing, intention planning, and goal-setting) on changes in physical activity.

recent analyses have indicated that physical activity reduces mortality risk among patients with rcc.1. physical activity also provides additional benefits for patients undergoing treatment for cancer such as improved quality of life and sleep, and reduced treatment-related fatigue. however, individuals receiving treatment for renal cell carcinoma (rcc) often fail to engage in sufficient physical activity. many cancer survivors experience a decrease in their physical activity after diagnosis2 and the majority of rcc survivors do not meet the recommended guidelines for physical activity.3 traditional physical activity interventions require significant resources and present substantial barriers for participants (travel, time commitments, etc.). in contrast, mobile technologies enable delivery of interventions with significantly fewer resources. these technologies also facilitate the delivery of just-in-time adaptive interventions (jitais) in which intervention support is provided at only at times when an opportunity for positive changes exists.4 the purpose of this support the development of a jitai in rcc patients. evaluation of the acceptability and efficacy of three intervention strategies (affective framing, intention planning, goal-setting, and savoring) will determine their inclusion in the jitai.

Eligibility criteria:
inclusion criteria: 1. ages 18 years or older 2. diagnosed with rcc 3. \< 150 minutes of weekly moderate-to-vigorous physical activity 4. own a smartphone (required for syncing the fitbit device). exclusion criteria: 1. medical condition contraindicating exercise participation 2. cognitively unable to give informed consent. 3. unable to read and communicate in english

Keywords: renal call carcinoma exercise physical activity mobile intervention just-in-time adaptive intervention affective framing intention planning
vitamine d dosage and constipation

Conditions: Vitamine d Dosage in Slow Transit Time Constipation

Summary: vitamine d dosage in important to define nutritional status and bone metabolism. for patients with intestinal disorders it is important to establish the intestinal absorptive function. it is important to establish the absorption of vitamin d which correlate with different biological activity and bone metabolism, immune function and the communication between the cells.

constipation is a disease that involves poor intestinal functioning. the reduced intestinal motility slows down intestinal function. up to make lower the dosage of vitamin d. vitamin d helps many cellular activities and enhances the action of tissue,its your dosage allows you to evaluate the efficacy of intestinal function and to better understand its severity.

Eligibility criteria:
inclusion criteria: * slow transit time constipation exclusion criteria: * drugs assumption comorbidity
hypoglossal nerve stimulation therapy in patients with obstructive sleep apnea: belgian registry

Conditions: Obstructive Sleep Apnea; Sleep Apnea; Apnea

Summary: hypoglossal nerve stimulation (hns) therapy (inspire system) is intended for the treatment of patients with moderate to severe obstructive sleep apnea (osa) who cannot be effectively treated with the first-line treatment options. recently, the request for reimbursement of the inspire system in belgium was approved. the aim is to create a multi-center registry of osa patients that are treated with hns (inspire system) within routine clinical care in belgium.

patients that are implanted with the inspire system in belgium will be invited to participate in the registry. data will be collected from different routine clinical care visits over a period of 5 years post-implantation. all assessments of the registry are part of the standard clinical care. data collection will include polysomnographic data, home sleep test data, therapy usage, device data and questionnaires (epworth sleepiness scale, functional outcomes of sleep questionnaire-30, visual analogue scale (vas) snoring. data will be collected from routine visits including: pre-implant, implant, activation, titration, follow-up (6, 12, 24, 36, 48 and 60 months post-implantation).

Eligibility criteria:
inclusion criteria: any patient implanted with or receiving the inspire hns system and who is able to give informed consent is eligible to participate in the registry. a patient is eligible for hns implantation if he/she meets the following criteria: * at least 18 years old at the time of implantation * the patient suffers from moderate to severe osa (15 events/h ≤ ahi ≤ 65 events/h) * the patient has failed, not tolerated or has a contraindication for continuous positive airway pressure (cpap) and/or mandibular advancement device (mad) therapy * absence of complete concentric collapse of the level of the soft palate during drug-induced sleep endoscopy (dise) exclusion criteria: * body mass index (bmi) \>32 kg/m². * combined mixed and central ahi is more than 25% of the total ahi * patients with complete concentric collapse at the level of the soft palate or any other anatomical deviation that could impede the proper functioning of hns * patients with severely impaired neurological control over the upper airway * pregnancy * surgery performed on the soft palate in the past three months before implantation.

Keywords: hypoglossal nerve stimulation registry routine clinical care
turkish validity and reliability study of the bipolar recovery questionnaire

Conditions: Bipolar Disorder, Recovery

Summary: in addition to objective criteria (no episode period for 6 months) for defining and monitoring recovery, evaluation of subjective criteria is also very important. various turkish scales related to recovery in progressive diseases have been developed or validity-reliability studies have been conducted. however, as far as we know, there is no scale that evaluates subjective improvement for a disorder such as bipolar disorder that progresses in episodes and has a heterogeneous appearance of loss of functionality. in this study, we aimed to conduct a validity and reliability study of the recovery questionnaire for bdd.


Eligibility criteria:
inclusion criteria: * being between 18-65 ages * be diagnosed with bipolar affective disorder * be at least primary school graduate exclusion criteria: * having a physical disability (blindness, etc.) that might prevent filling in the scales, * having an additional neurological disease that prevented filling out the scale items.
instruct-sci: independent observational study of cell transplantation in sci

Conditions: Spinal Cord Injuries

Summary: the investigation is a multi-year observational study following the completion of the open-label, single dose phase i/ii study involving transplantation of allogeneic hucns-sc cells into 12 subjects with thoracic spinal cord injury. subjects will be monitored at routine intervals for safety and preliminary efficacy for 5 years post-transplantation of the phase i/ii investigation cl-n02-sc.


Eligibility criteria:
inclusion criteria: * must have undergone hucns-sc transplantation as a subject in the phase i/ii trial * must be able to provide written informed consent prior to any study related procedures * must agree to comply in good faith with all conditions of the study and to attend all required study visits * female subjects who are pregnant remain eligible for enrollment, but the mri examination will not be performed during the pregnancy. female subjects of child-bearing potential must have a negative urine pregnancy test prior to the mri examination exclusion criteria: * subjects have received or are receiving off-protocol immunosuppressive medications * subjects who after completion of cl-n02-sc have entered, or are about to enter any other interventional study
concurrent and non-concurrent chemo-radiotherapy or radiotherapy alone with intensity-modulated radiotherapy (imrt) for non small cell lung cancer (nsclc) to an individualised mean lung dose (mld)

Conditions: Stage I-III Non-small Cell Lung Cancer

Summary: our group has shown that increasing the radiation dose to pre-specified normal tissue dose constraints could lead to increased tcp with the same ntcp in patients with non-concurrent and concurrent chemo-radiation. here, the investigators want to investigate its efficacy in a prospective study in patients with stage i-iii nsclc, who are selected for high-dose radiotherapy with or without chemotherapy, but treated with imrt. the latter technique has become standard, but the patterns of recurrence and the possibility for dose-escalation in an individualised setting have never been investigated properly.

eligible patients (see below) will receive radiotherapy to the primary tumor and the initially involved mediastinal lymph nodes to an mld (mean lung dose) of 20 +/-1gy, irrespective of lung function. other dose-constraints: spinal cord max: 54gy, brachial plexus (dmax):66gy in concurrence with chemotherapy, radiotherapy will be delivered as follows: * first three weeks/30 fractions: twice-daily fractions of 1.5gy, with 8h to 10h as interfraction interval, 5 days per week. total dose: 45gy/30 fractions * thereafter: once daily fractions of 2.0gy, 5 days per week until the target dose has been reached. in sequential or radiotherapy alone schedules, twice-daily 1.8gy with an interfraction interval of at least 8h will be delivered. the radiation doses will be specified according to icru 50. lung density corrections will be applied, as well as all standard qa procedures. technical requirements are the same as in standard practice at maastro clinic chemotherapy schedules allowed: 1. 1-2 cycles induction chemotherapy: any third generation schedule is allowed. the type will be registered. 2. concurrent part: (day 1 = first day of radiotherapy) * cisplatin - vinorelbine * cisplatin - docetaxel * cisplatin - etoposide * cisplatin - pemetrexed in non-squamous histologies q 3 weeks; 3 cycles when the calculated creatinin clearance is less than 60ml/min, cisplatin may be substituted for carboplatin

Eligibility criteria:
inclusion criteria: * histological or cytological proven nsclc * iucc stage i-iii, or solitary metastases (\<6), which are amendable for radical local treatment. * performance status 0-2 * imrt technique exclusion criteria: * not nsclc or mixed nsclc and other histologies (e.g. small cell carcinoma) * stage iv, except for solitary (\<6) metastases * performance status 3 or more * no imrt technique

Keywords: radiotherapy nsclc
evaluation of the effectiveness of self management program on changes in physical activity level of knee osteoarthritis patients in spa therapy

Conditions: Knee Osteoarthritis; Physical Activity; Education; Self-management; Exercise

Summary: the primary purpose is to evaluate the benefit of an education action of exercise on the level of physical activity in patients with knee osteoarthritis with the waning of a spa treatment for three weeks, three months after the start of the cure.

the aim of this study is to prove the effectiveness of an educational intervention in thermal environment on physical activity level with knee osteoarthritis patients.

Eligibility criteria:
inclusion criteria: * patients, male or female, aged 50 to 75 years. * patients with knee osteoarthritis clinical criteria of the american college of rheumatology (acr) * patient affiliated to a social security scheme (beneficiary entitled) * patient registered spa * patient has given its consent in writing to exclusion criteria: -

Keywords: physical activity level knee osteoarthritis randomized controlled trials alternate month design study self-management self-care education and exercise in knee osteoarthritis education non pharmacological treatment
assessment of stuttering severity in adults and adolescences in conversational and narrative contexts

Conditions: Stuttering

Summary: the aim of this study is to assess stuttering severity in both narration and conversation in adults and adolescences in order to determine which situation is more stressful so that more reliable and accurate measures for diagnosis can be done. also this study will help in determining the best line of management of stuttering.

stuttering is a speech disorder in which the flow of speech is disrupted by involuntary repetitions and prolongations of sounds, syllables, words or phrases as well as involuntary silent pauses or blocks. in the world, approximately 1% of the adult population suffer from stuttering. stuttering has severe impact on the overall quality of the person's life such as anxiety, stress, shame, low self-esteem and negative affectivity .it also affects his educational attainment, his attractiveness and work life as he avoids employment. stuttering varies in severity, frequency and duration from situation to situation. so its dynamics are best understood within discourse contexts that involve interactions with other people. clinicians typically rely on spontaneous conversational samples for analyzing speech disfluencies. they have good validity, but the use of a more structured form of speech may allow for more efficient, reliable elicitation of stuttering related behaviours and better understanding of the nature of stuttering. narration offers a more structured context than conversation because storytellers must weave together information about the characters, the circumstances and actions. also, narration often contains more complex language than conversation and put the whole responsibility on the speaker for planning and conveying the information to the listener, compared to conversation where two or more speakers co-construct the stream of topics and comments. thus, narration places more linguistic, cognitive and communicative demands on speakers than does conversation. a research was done on six adult participants and showed that some of them stuttered more during conversation and others stuttered more during narration.

Eligibility criteria:
inclusion criteria: 1. age :11-50 2. gender : both sex will be included in the study 3. iq \>85 4. no previous therapy exclusion criteria: * 1. presence of any other speech, language, physical or neuropsychatric disorders.
open-label extension to protocol 1042-0500

Conditions: Infantile Spasms

Summary: to allow open-label extension to patients who have completed protocol 1042-0500

patient should have completed all scheduled clinical study visits in the double blind, controlled trial (protocol 1042-0500) and have been deemed eligible (had a response to treatment) by the investigator. male or female, with a diagnosis of is with a video eeg (veeg) recording confirming the diagnosis. there will be a total of 14 visits over 99(+or-1)week. a 24-hr veeg is only required if the subject has been spasm-free for more than 24-hrs.

Eligibility criteria:
inclusion criteria: * have completed all scheduled clinical study visits in the previous protocol 1042 0500 and have been deemed eligible (no saes thought to be drug related and had a response to treatment) by the investigator. * be diagnosed with is regardless of etiology. diagnostic criteria: seizures consisting of single or repetitive short muscular contractions leading to flexion or extension. spasms may be characterized as tonic or myoclonic contractions, may occur singly or in clusters, and typically occur bilaterally and symmetrically. the eeg pattern must be consistent with the diagnosis of is (hypsarrhythmia, modified hypsarrhythmia, multifocal spike wave discharges, etc). * have a 24 hour veeg recording confirming the diagnosis of is. * have had a magnetic resonance imaging (mri) performed to determine any possible causes of is. * have been previously treated with 3 aeds or fewer. * have a parent/guardian who is properly informed of the nature and potential risks and benefits of the clinical study, is willing and capable of complying with all clinical study procedures, and has given informed consent in writing prior to entering the clinical study. exclusion criteria: * current treatment with more than 2 concomitant aeds. * have an active cns infection, demyelinating disease, degenerative neurological disease, or cns disease deemed progressive (with the exception of tuberous sclerosis) as evaluated by brain mri. * have any disease or condition (medical or surgical) at screening that might compromise the hematologic, cardiovascular, pulmonary, renal, gi, or hepatic systems; or other conditions that might interfere with the absorption, distribution, metabolism, or excretion of the investigational product, or would place the subject at increased risk. * aspartate transaminase (ast), alanine transaminase (alt), or total bilirubin greater than 4 times the upper limit of laboratory normal or any clinical laboratory value deemed clinically significant by the investigator. * history of recurrent status epilepticus. * have been exposed to any other investigational drug within 30 days prior to enrollment.

Keywords: infantile spasms anticonvulsant pediatric epilepsy west syndrome epileptic spasms