Kornimate/medical-research-clean huggingface dataset:
ultra-brief psychological treatments for emotional symptoms and disorders

Conditions: Depression - Major Depressive Disorder; Generalized Anxiety Disorder; Generalized Anxiety; Anxiety; Somatoform Disorders; Somatic Symptom Disorder (DSM-5); Somatization; Emotional Disorders

Summary: the main objective of this randomized clinical trial is to study if various modalities of brief (eight sessions) and ultra-brief (four sessions) transdiagnostic cognitive-behavioral treatment work for decrease emotional symptoms and disorders, as well as to find out which variables of cognition and of the intervention process itself are involved in the therapeutic improvement. the investigators will compare the interventions of four groups: brief group treatment (1), ultra-brief group treatment (2), ultra-brief individual treatment (3) with the ultra-brief relaxation (control) group. the main questions the study aims to answer are: * will the brief and ultra-brief treatment formats works better than the relaxation-based control group? * will results obtained between the brief group therapy group and the ultra-brief group therapy group be similar? * will the individual ultra brief therapy be more effective than the two group therapies because of common factors, such as the therapeutic alliance? * will group therapies be more beneficial for cost and in terms of capability to reduce emocional symptoms than individual therapy? participants will be randomly assigned to each of the groups and will receive the corresponding treatment, with different number of sessions. they will answer a series of questionnaires at the beginning and at the end of the intervention, as well as 3 months and 6 months after the end of the treatment.


Eligibility criteria:
inclusion criteria: - patients presenting negative emotional symptomatology (anxiety, depression or somatizations), mild or moderate. specifically, they will be included in the study if they present a score ≥ 5 on the phq-9, the gad-7 or the phq-15. exclusion criteria: * bipolar disorder, personality disorder, psychosis or substance abuse, indicated by scid-5-cv * recent suicide attempt. * severe emotional symptoms (phq-15 or gad-7 ≥ 15; or phq-9 ≥ 20).

Keywords: ultra-brief therapy brief therapy transdiagnostic therapy cognitive-behavioral therapy randomized controled trial
improvement of the diagnosis and medico-legal management of psychological trauma in patients involved in the terrorist attack in nice on the 14th july 2016

Conditions: Registration of a Complaint Following the Terrorist Attack of 14 July 2016

Summary: psychological trauma is a major public health concern that affects numerous patients who have experienced traumatic events. the objective of our research was to improve the diagnosis and management of persons experiencing such events. we will seek to determine factors brought into play in the construction of psychological trauma and the best way to identify them so as to implement the optimal management of patients and ensure recognition of this condition. in addition, in the context of our activity as expert witnesses, we will study the methods used to assess and quantify psychological trauma. in this respect, a medical appointment will be made by a nurse of the forensic medicine department of dijon chu. during this consultation, a self-report questionnaire will be completed by the patient alone to evaluate the level of acute stress followed by a psychiatric consultation and completion of the ies-r questionnaire with the doctor to identify symptoms of psychological trauma.


Eligibility criteria:
inclusion criteria: - patients who have registered a complaint leading to the involvement of the forensic medicine department of dijon chu to evaluate requests for temporary sick leave for psychological reasons following the event in nice on the 14 july 2016. exclusion criteria: * refusal of the patient to attend the consultation proposed by the forensic medicine department of dijon chu, * refusal of the patient to take part in a clinical study. * verbal information about the clinical study when the appointment was made by the forensic medicine nurse, * reiteration of the verbal information during the consultation, * a letter and an official information document given to each patient by the dijon chu research unit stating the objectives and methods of the clinical study, * contact details of the forensic medicine department given to patients if they have any questions about the study.
evoked potential recording during dbs surgery

Conditions: Movement Disorders in Children

Summary: deep brain stimulation (dbs) has been approved for treatment of dystonia by the fda under a humanitarian device exemption (hde) status. dbs has been shown to be very effective in the treatment of a variety of diseases such as parkinson's disease and essential tremor. it has been widely used for the treatment of primary and secondary dystonia as well. surgery involves the placement of the dbs electrode in one or two of the deep nuclei constituting the basal ganglia. a subcutaneous thoracic or abdominal implantable pulse generator is placed and connected to the intracranial electrode. pulsatile stimulation of the deep brain nuclei has been shown to result in significant improvement in many patients, including restoration of the ability to walk or make voluntary arm movements. a major difficulty with dbs is the accurate placement of the electrode. adult patients are usually awakened during surgery and micro electrode recordings are used to determine the optimal electrode effectiveness and monitor for side effects. this requires the patient to be awake and cooperate, while on the operating table. when dbs is performed in children, such testing is often not possible because the children are scared or not cooperative when awakened during surgery, the procedure is most often done for dystonia, which does not respond immediately, and dystonia may cause involuntary movements that could be dangerous in the operating room while the child's brain is exposed. as part of the routine clinical evaluation of target location in the operating room or neuromodulation unit, stimulation is performed using the deep brain or depth electrodes, typically at frequencies between 60hz and 185hz. for this research study, stimulation will occur at much lower frequencies, between 9hz and 20hz in order to be able to measure how electrical activity from the deep electrodes spreads to other electrodes or the scalp. as part of the research, peripheral nerves will also be stimulated at the wrist and knee at frequencies of 20hz to 150hz in order to measure the transmission of peripheral nerve stimulation to these areas of the brain. the investigators hope these additional studies will allow discovery for mechanisms that lead to movement disorders including dystonia, and that knowledge of these mechanisms will allow the investigators to develop new, safer, and more effective treatments in the future.


Eligibility criteria:
inclusion criteria: * - subjects 5 years of age and/or older (including adults, ages 18+) * has chronic, intractable (drug refractory), generalized dystonia * dbs surgery must be clinically indicated exclusion criteria: * contraindication to neurosurgery and or a potentially reversible cause of dystonia that does not include surgery.
effects of cervical spine retraction exercise with and without diaphragmatic breathing in forward head posture.

Conditions: Forward Head Posture

Summary: this study aims to determine the effect of combining diaphragmatic exercises with cervical retraction exercise on pain, disability, active range of motions of cervical spine and craniovertebral angle in individuals with forward head posture.

forward head posture altering breathing pattern is one of the most common musculoskeletal deformity. diaphragmatic exercises can reduce pain and disability levels, and correct forward head posture (fhp) in patients with neck discomfort. in this randomized clinical trial, fifty two participants displaying forward head posture (fhp) will be randomly assigned to one of the two intervention groups: the diaphragmatic exercises and cervical retraction exercise combined group or the cervical retraction exercise alone group. randomization will be performed using a convenient random sampling method via sealed opaque envelopes. each participant will receive a total of twelve treatment sessions over a four-week period. the efficacy of the interventions will be assessed at the beginning (first session), conclusion (twelfth session), and two weeks after completing the sessions. outcome measures, including pain intensity, disability levels, cervical range of motion, and craniovertebral angle (cva), will be evaluated using the numeric pain rating scale (nprs), neck disability index (ndi), universal goniometer and image j software, respectively. data will be analyzed using statistical package for the social sciences (spss) software version 26. normality of data will be assessed using the kolmogorov-smirnov test. for within-group comparisons, either repeated measures anova or the friedman test will be used. to compare changes between the groups, the independent t-test or mann-whitney u test will be applied, depending on the data distribution. the analysis of these outcome measures will provide valuable insights into the impact of the interventions on participants' symptoms and postural alignment.

Eligibility criteria:
inclusion criteria: * primary complaint of neck pain (pain on the posterior part of the cervical spine to the beginning of the thoracic area with or without pain in the shoulder girdle) * age from 20 to 35 years * both gender * cva \<49° (16) exclusion criteria: * any serious pathology such as tumor * had history of whiplash injury within 3 months of the examination, * underwent prior surgery to the cervical spine * currently using muscle relaxation medication. * degenerative conditions * exhibited positive neurologic signs consistent with nerve root compression. * patients with a history of respiratory disease, such as repeated bronchitis, pneumonia, asthma, pulmonary lymph nodes, pleurisy, cured tuberculosis and others
evaluation of an internet based education and support program for patients awaiting kidney transplantation

Conditions: Chronic Kidney Diseases

Summary: the goal of this study is to test the feasibility study of an internet based education and support program for patients awaiting kidney transplantation. the study is designed as a national pilot randomized controlled trial with a waitlist control group, to test the feasibility, acceptability, and potential effects of the intervention on patients' physical and mental health.

persons 18 years and older with severe renal failure and accepted on waiting list for kidney transplant with deceased donor in sweden since at least 6 months will be recruited for participation. recruitment will be performed through sweden's four transplant centers. exclusion criteria will include not considering themselves able to spend 3-4 hours/week to work in the program. the study will be performed using a study platform which is previously well tested. the intervention group the intervention is a support an education program, consisting of 9 modules running over 9 weeks. first, an introductory module is given that involves goal setting, followed by two training modules with information; the first on kidney disease, treatment and self-care in severe renal failure and while waiting for kidney transplantation, the second on kidney transplant-specific areas such as drugs, potential complications, lifestyle advice and self-care before and after kidney transplantation. this is followed by three behavioral components spread over five modules/weeks: acceptance (one module), problem solving (one module) and behavioral activation (three modules), and finally a summation module that focuses on consolidating the knowledge learned during the program. each module consists of texts, illustrations, short films, reminders to practice physical activity and weekly homework for which the people receive feedback from a contact person. any participants who are transplanted while undergoing the program will be offered to continue the study with adapted modules. adaptations involve more relevant examples and information regarding drugs, complications and diet which become more relevant after the transplant. waitlist control group the control group will be followed with weekly check-ups for 9 weeks via the study platform regarding well-being, whether they have been transplanted or if something happened that affects their life situation. after the intervention period of 9 weeks, the control group will be offered the same program as the intervention group.

Eligibility criteria:
inclusion criteria: * 18 years and older * severe renal failure and accepted on waiting list for kidney transplant with deceased donor in sweden since at least 6 months exclusion criteria: * not considering themselves able to spend 3-4 hours/week to work in the program * another illness that permanently renders kidney transplantation impossible

Keywords: kidney transplantation psychosocial support patient education e-health
faecal microbiota transplantation in irritable bowel syndrome

Conditions: Irritable Bowel Syndrome With Diarrhea; Irritable Bowel Syndrome Mixed

Summary: irritable bowel syndrome (ibs) is the most common functional bowel disorder, being present in approximately 10% of adult europoid population. the etiology of ibs is elusive. literature indicates that modification of patients´colonic microbiota might ameliorate the condition. here we test an intervention by faecal microbiota transplantation of artificially inflated microbiome diversity, versus autoclaved placebo.

three-groups, double-blind, placebo-controlled, randomised, cross-over study in adult patients diagnosed with ibs (diarrhoeal or mixed form) according to rome iv criteria. each study subject will undergo two pairs of faecal microbiota transplantation (a total of four enemas for each patient), with the pairs of transfers being eight weeks apart. the active intervention substance is a mixed stool microbiota derived from healthy individuals, screened for infectious diseases according to european consensus conference on faecal microbiota transplantation guidelines, and who were preselected for high alpha diversity of their microbiome and distance in community ordination from ibs patients microbiota. placebo is the same mixture, inactivated by autoclaving.

Eligibility criteria:
inclusion criteria: * diarrhea predominant irritable bowel syndrome (ibs-d) or irritable bowel syndrome with mixed bowel habits (ibs-m) according to the rome iv criteria exclusion criteria: * the use of antibiotics within one month prior to faecal microbiota transplantation * the use of probiotics within one month prior to faecal microbiota transplantation * history of inflammatory bowel disease or gastrointestinal malignancy, systemic autoimmune diseases (ongoing or in history) * previous abdominal surgery (other than appendectomy or cholecystectomy or hernioplasty or cesarean section) * hiv infection or other active infection * renal or hepatic disease (both defined by biochemistry workup) * diabetes mellitus, abnormal thyroid functions not controlled by thyroid medications * bipolar disorder or schizophrenia (ongoing or history thereof), moderately severe depression defined by patient health questionnaire-9 (phq-9) score \> 15 * anxiety defined by a generalised anxiety disorder 7 (gad7) score \> 10 * current pregnancy and lactation

Keywords: ibs - d, ibs - m
primary metastatic renal cell carcinoma treated with immunecheckpoint inhibitors and cytoreductive nephrectomy

Conditions: Renal Cell Carcinoma

Summary: the benefit of deferred cytoreductive nephrectomy (cn) has to be re-assessed in the context of io +io and io + tki systemic treatment. given the benefit of cn in the setting of first generation immunotherapy, it is conceivable that both trials underestimated the benefit of cn, in absence of immunotherapy.

in past years, much research has been done into the beneficial effects of cytoreductive nephrectomy in patients with metastatic renal cancer receiving systemic therapy with positive results. in the meantime systhemic therapy, and in particular immunotherapy, have changed. patients with metastatic renal cancer are increasingly treated with immunocheckpoint inhibitors, but the effect of adding cytoreductive nephrectomy in this group of patients has not yet been investigated. the aim of this study is to investigate whether performing a cytoreductive nephrectomy has a beneficial effect on overall survival in patients with metastatic renal cancer receiving systemic therapy using immunocheckpoint inhibitors. a randomized controlled trial. all eligible patients have already been enrolled in the pro-rcc registry, a registry that collects prospective observational data, and have also given consent to be included in other studies as a control cohort. this design is called a twic (trial within cohort). after randomization, patients who are randomized into the therapy arm will receive a patient information via their treating physician. upon participation, an informed consent will be signed and the patient will be scheduled for surgery.

Eligibility criteria:
inclusion criteria: 1. male or female patients age ≥ 18 years 2. signed and written informed consent note: written and signed informed consent will be obtained before any study procedures, including study-specific-screening procedures, has been performed. 3. informed consent obtained for being offered future experimental interventions within the pro-rcc project. 4. histologically confirmed diagnosis of metastatic clear cell, papillary or chromophobe renal cell carcinoma of intermediate to poor risk, including sarcomatoid features, with 5. world health organization (who) performance status of 0-1. 6. surgical candidates based on surgeon and anesthetist assessment 7. treatment with an io combination (io+io or io+tki) as standard of care for metastatic rcc 8. absence of progression at metastatic sites at time of identification (6month after start of systemic first line treatment). 9) primary tumor in situ 10) participation in the pro-rcc prospective cohort. exclusion criteria: na

Keywords: cytoreductive nephrectomy immunotherapy tyrosine kinase inhibitor
clinical and social trajectory of children and adolescents with disruptive behavior

Conditions: Disruptive Behavior

Summary: conduct disorders are defined as "repetitive and persistent pattern of behavior in which the basic rights of others or major age-appropriate norms are violated". so defined, these disorders are at the crossroads of psychiatry, social field and justice. conduct disorder management is a public health issue and a societal question. conduct disorders affect 5 to 9% of 15-year old boys. care management of children and adolescents admitted for disruptive behaviors in emergency rooms is an issue. no consensus or official recommendation exists. however, use of emergency care in this context is increasing in most western countries and it exposes to several risks (inappropriate use of hospitalizations, social rupture, ignorance of comorbidities and suicide risk). the trajectories project is designed to describe children and adolescents with disruptive behaviors, their care management and to follow their life trajectory and psychiatric evolution after admission to emergency rooms. better understanding this population will improve their medical and social care management, thereby giving professionals the right tools. the main objective of this project is to implement a multidisciplinary and integrative research combining clinical considerations and social sciences to determine the "trajectory" of this population.


Eligibility criteria:
inclusion criteria: * children and adolescents admitted to emergency rooms for aggressiveness, violence, fugue or theft exclusion criteria: * children and adolescents admitted to emergency rooms for a reason not directly link with aggressiveness, violence, fugue or theft * opposition to the subject or the family to participate to this research

Keywords: trajectory emergency room conduct disorder care management
study of the efficacy of the treatment of sleep apnea syndrome by cpap in pharmacoresistant epilepsy

Conditions: Sleep Apnea Syndromes; Epilepsies, Partial

Summary: study of the efficacy of the treatment of sleep apnea syndrome by cpap in pharmacoresistant epilepsy. the primary goal is to evaluate the efficacity after 3 months of obstructive sleep apnea syndrome treatment by cpap on the epilepsy seizures frequency.


Eligibility criteria:
inclusion criteria: * male or female age ≥ 18. * patient suffering of pharmacoresistant epilepsy. * frequency of epilepsy crisis : minimum 4 per month. * antiepileptic drug on a stable dose for at least 2 months. * sa-sdq score ≥ 25. * written informed consent obtained. * patient affiliated with a social security regimen. exclusion criteria: * pregnant females (female subjects who are lactating are not excluded). * anterior cpap treatment. * central apnea \>20% during the initial polysomnography. * mental retardation or severe cognitive impairment. * presence of pseudo-crisis.

Keywords: cpap sleep apnea syndrome pharmacoresistant epilepsy apnea hypopnea-index
the role of expectations in the development of intrusive memories

Conditions: Posttraumatic Stress Disorder

Summary: in the experimental study, the well-established trauma film paradigm will be used to investigate the impact of expectations on the development of intrusive memories as a hallmark symptom of ptsd.

the study aims to examine the influence of different expectations on the development of intrusive memories by using a well-established experimental paradigm - the trauma film paradigm. in healthy volunteers, intrusion-like symptoms are to be induced with an analogue stressor, i.e., aversive film clip footage (trauma film). after viewing this so-called trauma film, the expectations of intrusions during the following week are manipulated by assigning participants randomly to three different groups. in the first group, negative expectations are induced (experimental group 1), the second group is exposed to positive expectations (experimental group 2) and a third group does not face any kind of manipulation of their expectations (control group). participants are asked to report occurring intrusions in a diary during the following week and are invited to a subsequent cued laboratory inquiry at follow-up.

Eligibility criteria:
inclusion criteria: * healthy volunteers * fluent in german language exclusion criteria: * history of traumatic experiences (lec-5) * presence of a mental disorder (scid-i according to dsm-iv) * cut-off in depression screening (phq-9) * current suicidal thoughts/behavior or non-suicidal self-injury behavior (c-ssrs) * medical history of heart disease or epilepsy * history of fainting * work experience in the medical field (e.g., nurses, paramedics, etc.) * visual impairment * students of psychology and medicine