Kornimate/medical-research-clean huggingface dataset:
l-thyroxine supplementation for preterm newborns less than 32 weeks of gestation with hypothyroxinemia

Conditions: Hypothyroxinemia

Summary: transient hypothyroxinemia of prematurity (thop) is associated with neurodevelopmental impairment in preterm newborns \< 32 weeks of gestation (wg). it is not known whether l-thyroxine supplementation for preterm newborns \<32 wg with thop is beneficial. the purpose of this study is to compare l-thyroxine treatment vs. placebo in newborn less than 32 wg with thop. the primary endpoint is the neurodevelopmental outcome at two years of life, assessed by the brunet-lézine score. the secondary endpoints are: death, bronchopulmonary dysplasia (oxygen therapy at 28 days of life and at 36 weeks of postnatal age), patent ductus arteriosus, shock requiring fluid loading or vasoactive treatments, enterocolitis, intraventricular hemorrhage, retinopathy of prematurity, deafness.

preterm newborns \<32 weeks of gestation (wg) are screened for thop between day 5 and day 7 of life. thop is defined by thyroid-stimulating hormone (tsh) \< 20 miu/l and ft4 \< 0.80 ng/dl. after obtaining written consent from the parents, preterm newborns \<32 wg with thop will be included. randomization is stratified by center and 2 age-groups (24-28 wg and 29-32 wg). one arm will receive l-thyroxine treatment and the other arm will receive placebo. treatment will be started within one week after diagnosis and will last 6 weeks. tsh and ft4 will be assayed 2 weeks after stopping treatment. the primary endpoint is the neurodevelopmental outcome at two years of life, assessed by the brunet-lézine score.

Eligibility criteria:
inclusion criteria: * gestational age \< 32 wg * ft4 (5, 6 or 7 days of life) ≤ 0.8 ng/dl * tsh (5, 6 or 7 days of life) \< 20 miu/l * written consent from the parents exclusion criteria: * maternal thyroid disease * ft4 (5, 6 or 7 days of life) \> 0.8 ng/dl * tsh (5, 6 or 7 days of life) \> 20 miu/l * grade iii or iv intracerebral hemorrhage

Keywords: infant, newborn infant, preterm thyroid outcome newborns less than 32 weeks of gestation tsh < 20 miu/l and a ft4 < 0.80 ng/dl
clinical prognosis of patients with atrial fibrillation during radiofrequency ablation

Conditions: Atrial Fibrillation

Summary: this study is an ancillary study to isochrone-af. the investigators hypothesize that patients eligible but non-included in the primary study (patients classified as non-reducible or non-inducible) will have different prognosis and electro-physiclogical characteristics to the patients included and randomized into the isochrone af study.


Eligibility criteria:
inclusion criteria: * the patient must have given their free and informed consent and signed the consent form * the patient must be a member or beneficiary of a health insurance plan * the patient is at least 18 years old * the patient is available for 18 month follow-up * the patient has paroxysmal or persistent atrial fibrillation exclusion criteria: * the subject is participating in a category 1 interventional study, or is in a period of exclusion determined by a previous study * the subject refuses to sign the consent * it is impossible to give the subject informed information * the patient is under safeguard of justice or state guardianship * the patient is pregnant or breastfeeding early study exit criteria: patient does not have paroxysmal or persistent af at the time of inclusion
hand hygiene randomized cluster intervention to reduce infections

Conditions: Respiratory Tract Infections; Gastrointestinal Infections

Summary: the purpose of this study is to determine if a simple intervention to improve hand hygiene, consisting of a 3-4 minute training video, on-site posters, and hand hygiene supplies, can reduce respiratory and gi illness among employees.

the purpose of this study is to determine if a simple random cluster intervention trial to improve hand hygiene, consisting of a 3-4 minute training video, on-site posters, and hand hygiene supplies, can reduce respiratory and gi illness among those in the intervention group compared to the control group. the intervention was performed among employees in a midwestern public government setting. employees in the treatment group received a 3-4 minute training video online that was embedded in the baseline survey. motivational posters from the usdhhs encouraging proper hand hygiene were installed in the workplace, along with hand hygiene supplies. the control group received a program called "ask me 3" developed by the national patient safety foundation; the intervention consisted of a 3-4 minute training video to encourage clear communication with their health care providers, a brochure discussing the ask me 3 principles of clear communication with health care providers, and a key-ring with the ask me 3 communication principles to promote more effective communication with health care providers at visits out side of work. the groups were followed monthly through surveys over the internet for an average of three months after baseline to determine if a relative reduction in self-reported respiratory / gi infections occurred in the intervention group compared to the control group.

Eligibility criteria:
inclusion criteria: * all employees in respective departments participating in this study were included in the inclusion criteria exclusion criteria: * no employees were excluded if they worked in the participating departments in this study.

Keywords: hand hygiene communicable diseases respiratory tract infections primary prevention employees
retrospective review of gastrointestinal system endoscopy procedures

Conditions: Endoscopy; Colonoscopy; Gastroscopy; Colonic Polyps; Endoscopy, Digestive System; Gastrointestinal Neoplasms; Biopsy

Summary: the aim of the study is retrospectively evaluating all features of endoscopic and pathological diagnoses of cases who underwent upper and lower gastrointestinal endoscopy.

gastrointestinal system endoscopy has an important place in the diagnosis and treatment of many diseases related to this system and provides an alternative to current surgical methods with its ever-expanding field of application. upper and lower gastrointestinal endoscopy procedures are performed with many indications, such as new complaints in the gastrointestinal tract at the age of 50 and over, family history of gastrointestinal malignancy. in addition, the importance of endoscopy is gradually increasing as tissue and cell samples can be taken for histopathological studies and endoscopic treatment of some diseases. the aim of the study is to review patients' indications, distribution by age and gender, frequency of lesions diagnosed on endoscopy, prevalence, size, histology and location of polyps detected and excised, results of endoscopic and pathological diagnoses. the study population consists of the patients who were examined at the istanbul sultanbeyli state hospital endoscopy unit between 01.01.2016 and 01.01.2021. the patients' data will be scanned retrospectively by accessing their files from the computer database.

Eligibility criteria:
inclusion criteria: * adult patients (over 18 years old) * patients who have undergone the procedure in our endoscopy unit exclusion criteria: * under 18 years old * patients whose information cannot be accessed in the system records.
acoart iii / arterio-venous fistula in china

Conditions: Arteriovenous Fistula Stenosis

Summary: this trial is aimed to evaluate the safety and efficacy of dcb in treating avf stenosis in chinese population.

for years, first-line treatment of avfs stenoses has been percutaneous transluminal angioplasty. however, restenosis and reintervention rates remain incredibly high and occur, according to recent studies, in up to 60% and 70% of patients at 6 and 12 months, respectively. drug-coated balloons delivering paclitaxel at the angioplasty site have proved their superiority in the treatment of coronary and peripheral arterial stenoses. paclitaxel reduces neointimal hyperplasia and drug-coated balloons,therefore, it represents an attractive option for avf stenoses.

Eligibility criteria:
inclusion criteria: * age during 18-85 years old * arteriovenous fistula is matured and has undergone one or more hemodialysis sessions * venous stenosis of the av fistula * target lesion has stenosis ≥50% evidenced by angiography. and have at least one symptom of these：1,the venous pressure increased significantly during dialysis. 2,abnormal physical examination. 3,decrease in blood flow * the length of target lesion ≤100mm * patient able to give informed consent * residual stenosis ≤30% after predilation exclusion criteria: * women who are breastfeeding, pregnant or are intending to become pregnant * avf located at lower limbs * two or more than two stenosis at the target vessel. * obstruction of central venous return * isr * avf with acute thrombosis requiring lysis or thrombectomy in 30 days * vascular access has surgery in 30 days or intending to undergo a surgery * known hypersensitivity to aspirin, heparin, clopidogrel,paclitaxel, contrast medium, etc. * patients undergoing immunotherapy or suspected / confirmed vasculitis * patients with history of blood coagulation dysfunction and history of thrombocytopenic purpura * vascular access infection or systemic active infection * patients's life expectancy is less than 12 months * renal transplantation has been planned or converted to peritoneal dialysis * other medical conditions that lead to researchers who believe that patients may not be able to follow the trial program * involved in other drugs, biology, medical device research, or has been involved in other similar products clinical test

Keywords: drug eluting balloon
a new translational tool for studying the role of breathing in meditation

Conditions: Hypertension

Summary: a recent national health interview survey reported that breathing exercises were the second most common complementary and alternative medicine practice in the united states, following only the use of "natural products." with such widespread interest in breathing exercises, alone or as a component of practices such as meditation, a need exists for research that examines not only its efficacy, but also investigates potential mechanisms of action. indeed, a recent national center for complementary and alternative medicine (nccam) meditation workshop recommended research to clarify biological pathways by which meditation practices, including breathing exercises, can impact health. to explore mechanisms underlying the health effects of breathing exercises, new translational tools are needed that can measure breathing patterns in both the clinic and natural environment. the primary objective of the present proposal is the application of a new technology to the investigation of pathways by which breathing exercises can affect health. for this project, the health-related outcome measure to be studied is a major cardiovascular risk factor, blood pressure.


Eligibility criteria:
inclusion criteria * mean 24-hr sbp: 130-139 mmhg * female * \> 50 years of age * post menopausal, defined as greater than or equal to one year without a menstrual cycle. * body mass index (bmi): 19-31 * english speaking (patients not able to read and speak english will be excluded as the behavioral group interventions are conducted in english) * has a personal physician exclusion criteria (individuals will be filtered in the kp osca database according to the following icd-9 codes): respiration: * 491.x chronic bronchitis incl copd * 492.x emphysema * 493.x asthma * 494-496; 500-519: all kinds of chronic pulmonary conditions cardiovascular: * 404.9 chronic ischemic heart disease * 425.x cardiomyopathies * 428.x heart failure * 430-438 cerebrovascular diseases kidney: * 582-583 chronic glomerulonephritis * 584-588 renal failure liver: - 571.x chronic liver disease and cirrhosis smoker: 305.1 psychiatric: * 290-299 dementia/schizophrenia/ psychoses... * 303, 304 alcohol or drug dependence * 317-319 mental retardation medications: * all blood pressure medications * all tranquilizers, benzodiazepins if prescribed regularly, e.g. every month * all narcotics if prescribed regularly, e.g. every month other: - plan to relocate residence outside recruitment area during the intervention or follow- period

Keywords: hypertension blood pressure breathing petco2 stress
6-0 fast absorbing gut versus 5-0 fast absorbing gut for linear wound closure

Conditions: Surgical Wound Cosmesis

Summary: traditionally, dermatologic surgeons close wounds with stitches. fast absorbing gut is a dissolvable stitch that is very commonly used. some surgeons believe that using a thinner size of this stitch causes less skin reaction and improves the cosmetic outcome of the scar. other surgeons believe that using a thicker size of this stitch reduces the tension on the scar and improves the cosmetic outcome of the scar in that manner. the investigator wishes to determine whether the thickness of the fast absorbing gut suture that is used makes a difference in the cosmetic outcome of the scar.

the purpose of this study is to determine whether the use of 6-0 fast absorbing gut during repair of linear cutaneous surgery wounds on the face or neck improves scar cosmesis compared to wound closure with 5-0 fast absorbing gut. the investigator will use a split wound model, where half of the wound is repaired with 6-0 fast absorbing gut and the other half is repaired with 5-0 fast absorbing gut. three-months post-surgery, the scar will be measured via the patient observer scar assessment scale, a validated scar instrument. the scar width, and adverse events will also be recorded. this study aims to investigate whether 5-0 versus 6-0 fast absorbing gut suture leads to better surgical wound cosmesis on the head and neck. the 5-0 fast absorbing gut suture has a large diameter, and therefore greater tensile strength. the greater tensile strength would provide better support of the healing scar during the first 5-7 days after surgery and for this reason, could potentially lead to improved scar cosmesis. however, the greater diameter could also lead to track marks that are larger and more visible. furthermore, fast absorbing gut has a high degree of tissue reactivity to begin with, and it is known that larger diameter sutures generate more tissue reactivity compared to smaller diameter sutures of the same material; therefore, it is also possible that the 6-0 fast absorbing gut suture would provide better scar cosmesis by virtue of its lower tissue reactivity3,4.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * able to give informed consent themselves * patient scheduled for cutaneous surgical procedure on the head and neck with predicted primary closure * willing to return for follow up visit. exclusion criteria: * mentally handicapped * unable to understand written and oral english * incarceration * under 18 years of age * pregnant women * wounds with predicted closure length less than 3 cm

Keywords: cosmesis surgical wound fast absorbing gut linear cutaneous wound
smoking cessation in menthol flavored cigarette smokers

Conditions: Tobacco Use Disorder

Summary: the purpose of this study is to determine if in smokers of menthol cigarettes, switching to non-menthol cigarettes prior to a cessation attempt results in greater cessation success than attempting to quit without first switching


Eligibility criteria:
inclusion criteria: * self identify as african american * smoke primarily menthol cigarettes * be between the ages of 18 and 64 * smoke a minimum number of cigarettes per day * express an interest in quitting smoking exclusion criteria: * current unstable medical / psychiatric condition * regular use any form of nicotine or tobacco other than cigarettes * are pregnant or breast feeding the investigators will evaluate if there are other reasons why someone may not be eligible to participate
effectiveness of lyophilized growth factors for subacromial impingement

Conditions: Shoulder Impingement Syndrome

Summary: the aim of this study is to evaluate the efficacy of ultrasound-guided injection of platelet-derived lyophilized growth factors in treatment of subacromial impingement.

a new patented product named lyophilized growth factors has been developed. it is a novel advanced and refined form of conventional platelet-rich plasma. effectiveness of intra-articular lyophilized growth factors injection has been studied in thirty patients with symptomatic primary knee osteoarthritis and has shown encouraging results regarding improvement of pain, stiffness and function in addition to decreasing knee effusion. the lack of good quality evidence to support the efficacy of injecting platelet-derived lyophilized growth factors in treatment of subacromial impingement highlights the need for thorough evaluation of the outcome of this novel therapeutic option in patients with subacromial impingement.

Eligibility criteria:
inclusion criteria: * clinically: 1. anterolateral shoulder and/or lateral upper arm pain. 2. painful arc of motion between 70° and 120°. 3. positive impingement sign (neer's test or hawkins-kennedy test). * ultrasonographically: the elicitation of a transient arc of pain during shoulder abduction which coincides with passage of the supraspinatus insertion beneath the coraco-acromial arch. exclusion criteria: * history of shoulder surgery, fracture, dislocation or subluxation. * patients with full-thickness rotator cuff tear, weakness on arm elevation, or positive "drop arm sign". * patients who have been diagnosed with a frozen shoulder or degenerative arthropathy of the glenohumeral joint. * patients with disorders of the cervical spine or upper extremity that have a significant impact on the shoulder * patients with diabetes mellitus, rheumatoid arthritis, hypothyroidism or other painful or function limiting disorders of the shoulder. * significant cardiovascular, renal or hepatic disease. * active infection in the area to be treated.
pulmonary disease in a psychiatric inpatient population

Conditions: Chronic Obstructive Airway Disease

Summary: purpose: patients with mental health disorders have a reduced life expectancy, compared to the general population. the shorter life expectancy is caused by natural and unnatural death. in general, patients with a mental disorder tend to have a more unhealthy lifestyle, than the general population, characterized by e.g. lack of exercise and smoking. hypothesis chronic obstructive pulmonary disease (copd) is underdiagnosed in psychiatric inpatients there is a higher prevalence of copd in psychiatric inpatients compared to the general population screening of patients with one respiratory symptom and a smoking history, has the same sensitivity regarding to diagnosis of copd, as screening all patients with a smoking history method: 80 psychiatric inpatients will undergo spirometry with reversibility test and copd assessment test (catest). furthermore, patient history regarding respiratory symptoms and smoking will be taken into account.


Eligibility criteria:
inclusion criteria: * inpatients in psykiatrien syd, region zealand, ward s1,s2,s3,s4,s5,s6 * admission time over 48 hours exclusion criteria: * patients who is not able to perform spirometry due to their psychiatric condition

Keywords: copd psychiatric inpatient smoking
feasibility of pci using a 7-fr thin-walled sheath via the dra

Conditions: Coronary Artery Disease; Distal Radial Artery; Complex Intervention

Summary: to evaluate the safety and effectiveness of percutaneous coronary intervention using a 7-french(fr) thin-walled sheath via the distal radial approach

recently, coronary angiography (cag) and percutaneous coronary intervention (pci) via the distal radial artery access (dra) have shown several advantages owing to fewer complications, such as radial artery occlusion, pseudoaneurysms, and arteriovenous(av) fistulas, and short hemostasis duration than the proximal radial access (pra). however, despite the potential advantages of the dra, there are still many cardiologists who prefer the femoral approach for complex pci including left main disease, bifurcation lesions, heavily calcified lesions, which need a strong backup and using several devices. the radial artery and the distal radial artery have a smaller diameter than the femoral artery, and interventional cardiologists are usually performed using the 6-fr sheath. the previously developed 7-fr sheath has a higher risk of vascular occlusion when use in a radial artery due to larger diameter compared to radial artery in 30% to 60% of patients. however, with the recent development of various technologies, the outer diameter of the sheath is gradually becoming thinner and recently a 7-fr thin-walled sheath which does not differ significantly from the outer diameter of the 6-fr sheath used in the previously pra demonstrated that feasibility and safety for radial artery intervention. despite the feasibility and potential benefits of the dra and 7-fr thin-walled sheath for radial artery, there is a lack of data regarding the safety and efficacy of a 7-fr thin-walled sheath during the dra.

Eligibility criteria:
inclusion criteria: * patients, ≥ 19 years of age, who were diagnosed with ischemic heart disease requiring percutaneous coronary intervention (pci) * patients who are palpable distal radial artery * the decision to participate voluntarily in this study and the written consent of the patient * patients who planned to perform pci using a 7-fr thin-walled sheath exclusion criteria: * patients who are not palpable distal radial artery * female of childbearing potential, who possibly plans to become pregnant any time after enrollment into this study * pregnancy * patients who are not appropriate for this study

Keywords: distal radial artery coronary artery disease percutaneous coronary intervention
oral health and wilson's disease: somawi

Conditions: Wilson Disease

Summary: patients with wilson disease have poorer dental and periodontal health and a have lower oral quality of life than control patients. patients with a neurological form would also more frequently present limitations in the function of the masticatory apparatus. systemic treatments for wilson disease are associated with lesions of the oral mucosa. analysis of copper level in saliva could testify to the effectiveness of copper depletion in treated patients the main objective is to compare the state of dental health between: patients with wilson disease in the hepatic form and patients with the neurological form, and a population of controls.

the comparaison between the three groups is based on evaluation criteria wich is caod index of caries severity (developed by klein and palmer in 1940) counting the number of permanent teeth with caries (evolving to include non-cavitary caries) (c), absent due to caries (a) and filled (o) in an individual. the maximum score is 28 (third molars are not taken into account). the index is obtained from clinical examination and panoramic dental imaging.

Eligibility criteria:
inclusion criteria: * express consent to participate in the study * member of or beneficiary of a social security scheme * for cases: affected by wilson's disease * for controls: benefiting from a first routine dental consultation with dental panoramic imaging, outside of an emergency context or treatment follow-up/maintenance exclusion criteria: * patient benefiting from a legal protection measure * pregnant or breastfeeding women * severe psychiatric disorders with behavioral disorders * for cases: * hepatic or neurological decompensation * liver transplant patient * for witnesses: * patient with hepatic or neurological disease * patient taking dietary supplements enriched with copper or zinc or zinc supplementation * patient wearing removable prostheses with zinc-enriched prosthetic adhesives (fixodent proplus®)