Kornimate/medical-research-clean huggingface dataset:
ampholipad real-world data in taiwan

Conditions: Aspergillus Infection; Febrile Neutropenia; Candida Infection; Fungal Infection; Cryptococcal Infections

Summary: a retrospective, post-marketing, multi-center chart review study includes patients who had been prescribed ampholipad.

a retrospective, post-marketing, multi-center chart review study includes patients who had been prescribed ampholipad in selected sentinel hospitals in taiwan. medical charts of approximately 100 treated patients will be reviewed by the investigators to collect the pre-specified data, including indication, underlying cancer type (only for cancer patients), demographics, and concomitant medications as well as all the laboratory examination data regarding renal function from 1 month prior to first dose of ampholipad up to 1 week after the last dose of the initial treatment course.

Eligibility criteria:
inclusion criteria: 1. male or female ≥ 2 years of age 2. patients who had received at least one dose of ampholipad treatment, with available baseline serum creatinine (scr) data within 1 month prior to first ampholipad use and at least one post baseline scr data during treatment period exclusion criteria: 1. patients whose medical chart cannot provide both the start and stop dates of ampholipad for a course of treatment (first course only) 2. patients who had documented hiv infection diagnosis 3. patients with potential end-stage renal disease (esrd) receiving regular dialysis within 1 month prior to first ampholipad use
assessment and management of pain, agitation, delirium and sleep deprivation (pads) in icu by pads protocol, thailand

Conditions: Pain; Agitation on Recovery From Sedation; Delirium

Summary: the investigators proposed that pain, agitation, delirium and sleep deprivation protocol (pads) will help improve the patients' outcomes (shortening icu length of stay, improving ventilator free days, increasing delirium free days) in critically ill patients, a university hospital, thailand.

pain is frequently reported in patients admitted to an icu, with an incidence of up to 50% in medical patients during admission, and increasing up to 80% during standard care procedures. agitation was also reported in 52% of the patients, typically within 4-9 days after admission. however, there were studies reporting inadequate pain, agitation and delirium assessment and management in real-world clinical practice. the clinical practice guideline for the management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the icu was recently published in 2018 and emphasized routinely monitoring pain, agitation and delirium during icu admissions. also, appropriate management of pain and agitation in critically ill patients resulted in reduction in icu length of stay, hospital length of stay, delirium and mortality. therefore, structural pain, agitation/sedation, delirium assessment and treatment in the icus, thailand might be necessary. since pain, agitation/sedation and delirium protocol has not yet been initiated in icus, thailand, this study is designed as a before-after study in order to assess outcomes by comparing between before and after protocol initiation. the objectives of the study were to document the impact of pain, agitation/sedation, delirium protocol on clinical outcomes of icu patients admitted to icus at ramathibodi hospital, a university hospital, thailand

Eligibility criteria:
inclusion criteria: * adults (18 years and older) * patients admitted to medical or surgical intensive care units exclusion criteria: * terminal ill patients, or patients unlikely to survive \> 24 hours

Keywords: pain agitation sedation delirium protocol
ridge preservation comparing an intrasocket graft alone to an intrasocket graft plus a facial overlay graft

Conditions: Clinical Efficacy

Summary: the purpose of this study is to compare two methods of ridge preservation in the maxillary anterior esthetic zone to determine the best method to establish adequate bone and soft tissue to accommodate implant placement. for the positive control group a mineralized cancellous allograft will be placed in the extraction socket. for the test group a mineralized cancellous allograft will be placed in the extraction socket plus an additional graft will be placed to overlay the facial surface of the socket that will be composed of bovine xenograft material. outcomes will be clinical horizontal and vertical dimensional change and histologic analysis of the graft material at 4 months post-placement.

subjects met the eligibility criteria if they were at least 18 years of age and had one nonmolar tooth requiring extraction that would be replaced by a dental implant. extraction sites were bordered by at least one tooth. exclusion criteria included: 1) debilitating systemic diseases, or diseases that have a clinically significant effect on the periodontium; 2) molar extraction sites; 3) presence of or history of osteonecrosis of the jaws; 4) history of iv bisphosphonate treatment; 5) history of oral bisphosphonate treatment for more than three years; 6) pregnancy or lactation; 7) known allergy to any material or medication used in the study; 8) required antibiotic prophylaxis; 9) previous head and neck radiation therapy; 10) history of chemotherapy in the last 12 months; 11) long term steroid or non-steroidal anti-inflammatory drug therapy; or 12) failure to sign an informed consent approved by the human studies committee. patients were excluded post-treatment if they developed infection or had an adverse reaction to any of the materials used in the study.

Eligibility criteria:
inclusion criteria: 1. have one non-molar tooth requiring extraction that will be replaced by a dental implant. the site must be bordered by at least one tooth. 2. healthy person that is at least 18 years old. 3. patients must sign an informed consent approved by the university of louisville human studies committee. exclusion criteria: 1. patients with debilitating systemic diseases, or diseases that have a clinically significant effect on the periodontium. 2. molar teeth. 3. presence of or history of osteonecrosis of the jaws. 4. patients who are currently taking iv bisphosphonates or who had iv treatment with bisphosphonates irrespective of the duration. 5. patients who have been treated with oral bisphosphonates for more than three years. 6. pregnant women due to the possibility of miscarriage. 7. patients with an allergy to any material or medication used in the study. 8. patients who need prophylactic antibiotics. 9. previous head and neck radiation therapy. 10. chemotherapy in the previous 12 months. 11. patients on long term nsaid or steroid therapy.

Keywords: graft placement bone resorption
effects of transcranial direct current stimulation (tdcs) on rotator cuff fatigue.

Conditions: Asymptomatic Condition

Summary: the aim of this study will be to determine the effects of active tdcs on rotator cuff fatigue. this study will be a randomized, double-blind, sham-controlled, cross-over clinical trial based on non-probabilistic sampling for convenience, comprising a sample of 20 active asymptomatic subjects of all genders and aged between 18 and 35 years old. subjects will be recruited via social networks, whatsapp and emails and must be currently engaged in moderate physical activity (assessed by the ipaq questionnaire) and asymptomatic at the time of assessment. in addition, participants will be asked not to perform any type of strenuous exercise and do not drink alcoholic or caffeinated beverages during the time the work is performed. the study will consist of three sessions, with an interval of 72 hours between them.


Eligibility criteria:
inclusion criteria: * age ranging between 18 to 35 years, all genders. * healthy subjects * moderate physical activity (evaluated by ipaq questionnaire) * do not perform any exhausting exercise and do not drink alcoholic or caffeinated beverages during the time the work is performed. exclusion criteria: * subjects with trauma in the last three weeks or previous surgeries on the upper extremity, patients with pre-existing neurological or rheumatic conditions, pregnancy, medical history of epilepsy the convulsive event, subjects under analgesic drug treatment or have ingested drugs with central action in the last 72 hours.

Keywords: brain stimulation tdcs fatigue rotator cuff
pulsed dye laser in treating patients with post radiation dysphonia

Conditions: Oral Complications of Radiation Therapy; Stage I Laryngeal Cancer; Stage II Laryngeal Cancer

Summary: this pilot trial studies pulsed dye laser in treating patients with post radiation dysphonia. dysphonia, or vocal cord scarring, can include trouble with the voice when trying to talk, such as hoarseness, change in voice pitch, and poor voice quality, and it commonly happens after radiation therapy for laryngeal cancer. pulsed dye laser may improve post radiation dysphonia.

primary objectives: i. to evaluate the use of pulsed dye laser in treatment of the dysphonia that commonly results after radiation therapy for laryngeal carcinoma. outline: patients undergo pulsed dye laser monthly for three months. after completion of study treatment, patients are followed up at 1, 3, and 6 months.

Eligibility criteria:
inclusion criteria: * patients suffering from dysphonia after radiation therapy for glottic carcinoma will be included in the study * patients will be included if their initial stage was t1 n0 m0 or t2 n0 m0 exclusion criteria: * patients having previously undergone large surgical resections of the larynx or hypopharynx will be excluded * patients fewer than 1 year out from completion of radiation therapy will be excluded * patients with local disease recurrence would be excluded from the trial * patients in whom the transnasal endoscope is poorly tolerated or patients in whom transnasal endoscopic laryngoscopy is contraindicated will be excluded
in-home evaluation of a noninvasive open ventilation system in patients with severe respiratory insufficiency

Conditions: Pulmonary Disease, Chronic Obstructive; Airflow Obstruction, Chronic; Chronic Obstructive Airway Disease; Chronic Obstructive Lung Disease

Summary: the breathe niov™ system will reduce the work of breathing in subjects with chronic respiratory insufficiency who require long-term oxygen therapy (ltot). the breathe system will accomplish this by providing oxygen under pressure and augmenting the subject's spontaneous tidal volumes. the combination of efficient oxygen delivery, assisted ventilation, and a comfortable low-profile device, will result in a mean improvement in perceived well-being and ability to perform adls, as measured by patient-reported outcome (pro) instruments.

this will be a prospective, open-label, crossover study in up to 12 stable subjects with chronic respiratory insufficiency who require ltot. each subject's standard oxygen therapy will be used as the control treatment and compared to the test ventilator system during selected activities of daily living. subjects will participate in the study for up to 9 home visits, with visits 1 and 2 each lasting for approximately 4 hours, and visits 3-9 lasting approximately 1-2 hours each. subjects may discontinue study participation at any time.

Eligibility criteria:
inclusion criteria: * adult male and female subjects, 21-80 years of age * diagnosis of chronic respiratory insufficiency including copd and interstitial lung disease * requires use of continuous nasal oxygen of at least 2 lpm * reports limitation of activity due to fatigue or breathlessness * fluent in written and spoken english language * ability to be properly fitted with the breathe nasal mask * ability to tolerate and be appropriately titrated on the breathe ventilator * ability to communicate self-assessment of dyspnea, comfort, and fatigue * ability and willingness to participate in the study including walking and other activities of daily living * ability to provide written informed consent exclusion criteria: * recent history of frequent or severe epistaxis * symptoms of acute respiratory exacerbation within 48 hours of study day 1 * discharge from the hospital within 30 days of study enrollment * subjects, who in the opinion of the investigator, are not suitable candidates for enrollment or who are unlikely to be able to comply with trial requirements * subjects with conditions that, in the investigator's opinion, contraindicates study participation
type 2 diabetes and bone microarchitecture

Conditions: Type 2 Diabetes

Summary: type 2 diabetes is a major public health problem, associated with an increased risk of fractures. diabetes even appears to be the most important predictor of low kinetic fractures in men and women, and the risk of hip fracture in type 2 diabetics is increased by 40 to 50%, with often more serious consequences (post-operative complications, longer hospital stays, increased mortality rate). currently, the risk of fractures is estimated by the measure of areal bone mineral density (abmd) and t-score. however, in diabetics abmd is not decreased, and even paradoxically increased. indeed, abmd is 5-10% higher in type 2 diabetic patients compared to non-diabetic subjects, which suggests that the assessment of fracture risk in these patients is underestimated. the high resolution peripheral quantitative computed tomography (hr-pqct) 3d bone imaging technique has a resolution close to the size of the bone trabeculae. it is used to assess volumetric bone mineral density (vbmd) and bone microarchitecture at the tibia and distal radius, and enables a better estimation of the fracture risk compared to the measurement of abmd. our hypothesis is that bone microarchitecture is altered in type 2 diabetic patients, explaining the increased risk of fracture in this population compared to non-diabetics. we propose to set up a descriptive case control study, nestled in 3 cohorts of men and women (qualyor, ofely and strambo), to compare the bone micro-architecture measured by hr-pqct at the level of the tibia and distal radius, in type 2 diabetics compared to non-diabetic subjects from the same cohorts.


Eligibility criteria:
inclusion criteria: * men and women included in the 3 cohorts (qualyor, ofely, strambo) presenting type 2 diabetes * age- and sex-matched control patients from the same cohorts without type 2 diabetes ; two control were age- and sex-matched to one type 2 diabetes patient. exclusion criteria: -
effects of intensive locomotor treadmill training on gross motor function in young children with neuromotor impairment

Conditions: Cerebral Palsy

Summary: the purpose of this project is to examine if early exposure to intensive, short-term locomotor treadmill training (lt) in young children with neuromotor impairment will help develop walking skills earlier, decrease the amount of outside assistance needed (such as a walker or crutches) as compared to children with neuromotor impairment who receive traditional physical therapy intervention.


Eligibility criteria:
inclusion criteria: * a diagnosis of cp with gmfcs levels i and ii * ages 9 to 36 months * the ability to sit for at least 30 seconds unsupported in ring-sitting or w-sitting * the ability to take ten consecutive steps when held on hands exclusion criteria: * a diagnosis of a genetic syndrome * independent ambulation without an assistive device * previous or current use of treadmill intervention during physical therapy * a medical contraindication for standing or walking defined by the physician 5) uncontrolled seizures * a history of orthopedic surgery * use of medication to control spasticity in the past 6 months

Keywords: cerebral palsy treadmill training
comparison of in-lab psg to wp200 for assessing sleep parameters

Conditions: Sleep

Summary: the wp200 and/or wp200u will be compared with a psg system which is a digital physiological recorder system, cleared for use for clinical sleep studies. the manual scoring of the psg data, performed by a trained and authorized scorer, according to the aasm (american academy of sleep medicine) guidelines, serves as a "gold standard" for all determinations of efficacy.


Eligibility criteria:
inclusion criteria: * age between 12-17 * subjects with a legal guardian that is able to read understand and sign the informed consent form * willing to sleep with the wp200/wp200u and psg simultaneously in the sleep lab exclusion criteria: * permanent pacemaker: atrial pacing or vvi without sinus rhythm. * use of one of the following medications: alpha blockers, short acting nitrates (less than 3 hours before the study)

Keywords: diagnosing sleep
exercise intervention after lung cancer surgery

Conditions: Rehabilitation After Lung Cancer Surgery

Summary: a combination of supervised and un-supervised exercise in patients after lung cancer surgery is evaluated with regards to aerobic capacity, strength, physical activity and health-related quality of life.


Eligibility criteria:
inclusion criteria: * elective lung cancer surgery * ability to perform tests * able to communicate in swedish * willing to participate in supervised exercise exclusion criteria: -
effects of virtual reality exercise on promoting physical activity and health among college students

Conditions: Physical Activity Levels; Cardiovascular Fitness; Body Composition; Situational Motivation; Situational Interest; Mood States; Depressive Symptoms

Summary: the purpose of this research is to examine the effectiveness of a 4-week immersive-virtual reality (vr) exercise bike intervention on college students' physiological outcomes (physical activity levels, cardiovascular fitness, and body composition) and psychological outcomes (situational motivation, situational interest, mood states, and depressive symptoms).


Eligibility criteria:
inclusion criteria: * college students age from 18 to 35 years old who are currently enrolled in the university * college students without diagnosed physical and/or mental disabilities * must be willing to provide informed consent and compete the pa readiness questionnaire (par-q) * must be willing to be randomized into an intervention or control group * no self-reported motion sickness symptoms during immersive vr-based exercise exclusion criteria: * students under the age of 18 or over the age of 35 years old or not currently enrolled in the university * having self-reported physical and/or mental disabilities * contradictions to pa participation as determined by par-q responses * having motion sickness reaction when exercising under vr-based condition.

Keywords: exergaming physical activity virtual reality video games vr games physical activity levels cardiovascular fitness
wrx distal radius wrist fracture study

Conditions: Wrist Fracture

Summary: this research project is a multi-year proposal, with the goals of answering and evaluating the following: 1. does an intramedullary locking device applied in an extra-articular distal radius fracture improve post operative pain, diminish hospitalization, improve early return to activity and function compared to a volar locked plate? 2. does an intramedullary locking device applied in an extra-articular distal radius fracture improve patient related outcome measures compared to a volar locked plate?


Eligibility criteria:
inclusion criteria the following criteria must be met to be enrolled: 1. have a closed extra-articular distal radius fracture or a minimally displaced intra-articular component 2. have a fracture classified as an ao type a or c1 with or without an ulnar styloid fracture 3. be a male or non-pregnant female at least 18 years of age. 4. understand the requirements of the study and able to provide a written informed consent and comply with the study protocol 5. have the ability to understand and provide written authorization for use and disclosure of personal health information 6. have a fracture that can be closed reduced to acceptable radiographic parameters (minimum of neutral volar tilt, greater than or equal to 15 degrees of radial inclination and at least 10 mm of radial height as compared to the opposite side) exclusion criteria subjects are excluded if: 1. have any of the following conditions 1. concomitant contralateral or ipsilateral upper extremity fractures 2. ipsilateral ulna (excluding styloid) fracture 3. open, multifragmentary fracture 4. unstable distal radioulnar joint after fracture fixation 5. artery or nerve injury secondary to fracture 2. previous ipsilateral distal radius fracture in the 2 years prior to enrollment with deformity 3. currently on chemotherapy or radiation therapy 4. history of a metabolic disorder affecting the skeletal system other than osteoarthritis or osteoporosis 5. history of uncontrolled diabetes 6. history of active rheumatologic disease with deformity 7. history of chronic pain issues, psychiatric disorder which precludes reliable follow-up 8. unable to provide consent for the study 9. unable to make the follow-up appointments required of the study

Keywords: wrist fracture
clinical validation of the intervenn ovarian cancer liquid biopsy

Conditions: Adnexal Mass; Ovarian Cancer; Pelvic Mass

Summary: venn biosciences corporation ("intervenn") has developed a liquid biopsy that is capable of distinguishing benign from malignant masses in women presenting with adnexal (pelvic) masses, through a simple blood test. the underlying technology combines mass spectrometry and artificial intelligence/machine learning to analyze tumor-associated changes in circulating glycoproteins. the purpose of this study is to prospectively collect de-identified biological samples and data from women with a known pelvic mass, in order to validate ovarian cancer specific glycoproteomic signatures in the blood based on histologically confirmed malignancy status of the mass.

this is a prospective, international, multi-center, observational study with a goal of collecting de-identified samples and data from 1,200 women with a known pelvic mass. participants will consent to baseline and follow-up data and biospecimen collections.

Eligibility criteria:
inclusion criteria: * women age 18 years or older * able to provide a written informed consent and who understand and agree to all study procedures required * a newly diagnosed adnexal mass as confirmed by imaging (computed tomography, ultrasonography, or magnetic resonance imaging) prior to enrollment * planned diagnostic procedure or surgery by the subject's physician to remove adnexal masses within 90 days of imaging. (note that diagnostic procedure typically includes biopsy (needle core or laparoscopic-directed), ascites cytology, pleural effusion cytology or fna) exclusion criteria: * had/has a diagnosis of invasive malignancy (exception: non-melanoma skin cancers) in the previous 5 years. * currently receiving or ever received any of the following prior cancer therapies in the previous 5 years. this includes curative surgical resection, local or systemic chemotherapy, targeted therapy, immunotherapy including cancer vaccines, hormone therapy, and/or radiation therapy. * pregnancy * current febrile illness * acute exacerbation or flare of an inflammatory condition requiring escalation in therapy * recipient of organ transplant * poor health status or unfit to tolerate blood draw in addition, this study will include a small subgroup of women with a newly diagnosed clinically benign adnexal mass(es) for whom surgery is not planned as determined by the treating physician. this subgroup will follow the same exclusion criteria as listed above.

Keywords: intervenn ovarian cancer liquid biopsy mass spectrometry adnexal mass/ pelvic mass venn biosciences vocal study