Kornimate/medical-research-clean huggingface dataset:
immunogenicity/safety of measles-mumps-rubella-varicella vaccine (memuru-oka): using two different administration routes

Conditions: Measles; Mumps; Rubella; Varicella

Summary: this study will compare the immunogenicity and safety of the memuru-oka vaccine administered subcutaneously or using an alternative administration route.


Eligibility criteria:
inclusion criteria: * children must be healthy and have a birth weight \> 2000 g to participate exclusion criteria: * confirmed or suspected tuberculosis, immunosuppressive (including hiv) conditions, neurological disorders, history of allergic disease or reaction, major congenital defects, chronical administration of salicylates, and fever (axillary temperature ³ 37.5°c at the time of vaccination) are excluding factors. * children from pregnant mothers who have a negative history of chickenpox are also excluded from the study. * children must have received one dose (but not more) of mmr and of varicella at least 6 weeks before entering the study. they must not receive or have received other non-registered drug or vaccine within 30 days prior to study start, or immunosuppressants for more than 14 days. * immunoglobulins or any blood products are prohibited during the 6 months before and during the study, as well as vaccine other than that foreseen by the protocol within 30 days before vaccination. * children must not have had measles, mumps, rubella or varicella/zoster, or have been exposed to those diseases within 30 days prior to study start. * new-born infants (\< 5 weeks of age), pregnant women without previous exposure to chickenpox, and immunodeficient persons cannot live in the same household as the vaccinated child
chronic pain after video-assisted thoracoscopic surgery (vats) surgery for pneumothorax

Conditions: Pneumothorax

Summary: the study will investigate characteristics of chronic pain after vats surgery with two different sizes of videoscopic equipment.


Eligibility criteria:
inclusion criteria: * psp * able to understand and give consent * can read * residing in denmark exclusion criteria: * unable to understand the written information in danish * abuse (medicine, drugs, alcohol) * severe psychiatric illness * conflicting neurological disease * conversion to open surgery * use of neuroaxial analgesia * use of electric cauterizer necessitated * additional thoracic surgery in the investigation period

Keywords: persistent pain neuropathic pain chronic pain vats primary spontaneous pneumothorax patients
post-extubation dysphagia

Conditions: Post-extubation Dysphagia

Summary: mechanical ventilation is a widely used treatment on the intensive care unit (icu). swallowing dysfunction (dysphagia) after extubation may cause aspiration, and is associated with poor outcomes: pneumonia, reintubation, a prolonged length of hospital stay and increased mortality. the exact underlying pathophysiology of post-extubation dysphagia (ped) is unknown. this exploratory pilot study is the first step that aims to fill this knowledge gap to ultimately improve current treatment and prevention of post-extubation dysphagia. using fees (flexible endoscopic evaluation of swallowing), hrim (high resolution impedance manometry) and emg (electromyography) simultaneously, 5 healthy subjects and 25 patients within 24 hours after extubation will be studied.

observational study model: the group of healthy subjects will be recruited using posters at the local university and the internet. the healthy subjects will be studied before the group of patients to assess the feasibility and possible interactions of simultaneously recording fees, hrim and emg. then, the group of patients will be studied. they will be recruited from the intensive care unit. see in- and exclusion criteria for details.

Eligibility criteria:
inclusion criteria (patients): * age \> 18 years * informed consent * extubated after endotracheal intubation for more than 5 days * richmond agitation-sedation scale (rass) between -2 and 2 * able to sit right up * no respiratory insufficiency/failure (for this study defined as oxygen saturation (spo2) \< 92% with a minimum of 3 l nasal oxygen) inclusion criteria (healthy subjects): * age \> 18 years * informed consent exclusion criteria (both patients and healthy subjects): * pre-existing dysphagia (according to medical record and screening) * tracheostomy or previous tracheostomy * history of prior intubation \< 3 months ago * head/neck surgery, head/neck radiation or head/neck disease * pre-existent esophageal disorder * coagulopathy (thrombocytes \ 1.5 times the reference value, or fibrinogen \< 1000 mg/l, or use of therapeutic anticoagulant drugs) * allergy for xylometazoline (only in case its use is indicated) * known pregnancy * known g6pd deficiency

Keywords: flexible endoscopic evaluation of swallowing high resolution impedance manometry electromyography intensive care unit
effect of dry needling on quality of life in patients with trigger fingers

Conditions: Trigger Finger Disorder

Summary: this study will be conducted to investigate the effect of dry needling on quality of life in patients with trigger finger

trigger finger (tf) is one of the most prevalent causes of hand disability and is a common cause of referral to orthopedic clinics. trigger finger is tenosynovitis of the flexor sheaths that typically occurs in the 4th finger and thumb as a result of repetitive use. the incidence of tf is 28:100,000 per year or lifetime risk of 2.6% in the general population. it has the highest incidence being between 52 and 62 years more in women (75%). thumb and fourth digit (ring finger) are the most commonly affected fingers. dry needling (dn) is a relatively new technique used by physical therapists to treat myofascial trigger points (mtrps) and various pain syndromes. dry needling is defined as a "skilled intervention using a thin filiform needle to penetrate the skin that stimulates myofascial trps, muscles, and connective tissue for the treatment of musculoskeletal pain disorders. dn has analgesic and anti-inflammatory effects, it is commonly used to relieve pain and reduce inflammation.

Eligibility criteria:
inclusion criteria: * 40 patients all have trigger fingers lasting at least 4 weeks. * both gender will be included * age of patients will be 45-75 years old * pain and tenderness at the position of a1 pulley. * nodule palpation, pain, and discomfort when flexing and extending the finger, presence of a clicking sound at the time of flexion or extension of the finger, snapping or locking of the finger. * willing and able to complete study procedures. exclusion criteria: * participants with diabetes mellitus. * history of trauma, and rheumatoid arthritis. * dialysis treatment. * fingers with a history of local gouty/pyogenic disease. * major hand trauma and fear of needles. * any contraindication for deep dry needling such as anticoagulants, infections, bleeding, or psychotic conditions tumors, calcium deposits, or severe osteoarthritis.
role of montelukast in preventing relapse in childhood idiopathic nephrotic syndrome

Conditions: Nephrotic Syndrome

Summary: the investigators planned this research to elucidate if there is any efficacy of montelukast, a leukotriene receptor antagonist, in steroid sensitive childhood onset ns to help prevent relapses. this study was done to know the role of leukotriene receptor antagonist (ltra) montelukast in preventing relapses in idiopathic childhood nephrotic syndrome (ns)

a quasi-experimental study, done at department of pediatric nephrology at the children's hospital \& the institute of child health, multan. a total of 96 patients aged 1-10 years with steroid sensitive idiopathic ns were assigned into two groups (48 patients in each group). the case group received montelukast 5mg daily at bed time while the control group was not given montelukast. steroid treatment protocol was the same for the two groups as per institutional guidelines. patients were monitored and followed for the response to treatment and evidence of relapse over the study period (minimum 12 months).

Eligibility criteria:
inclusion criteria:a total of 106 children aged 1-10 years with idiopathic nephrotic syndrome were enrolled - exclusion criteria: - patients having steroid resistant nephrotic syndrome (srns) or those having nephrotic syndrome with atypical features or secondary cause were excluded.

Keywords: leukotriene antagonists nephrotic syndrome steroid
gaucher disease outcome survey (gos)

Conditions: Gaucher Disease

Summary: the gaucher outcomes survey (gos) is an ongoing observational, international, multi-center, long-term registry of patients with gaucher disease irrespective of their treatment status or type of treatment received. no experimental intervention is involved. patients undergo clinical assessments and receive care as determined by the patients' treating physician. the objectives of the registry include to evaluate the safety and long-term effectiveness of velaglucerase alfa, to characterize patients receiving velaglucerase alfa or other gaucher disease-specific treatments, to gain a better understanding of the natural history of gd and to serve as a database for evidence-based management of gaucher disease over time in real-life clinical practice.

20 may 2020: the temporary enrollment stop of new patients into this study due to the covid-10 pandemic has been lifted in one or more countries/sites, and the study is now again enrolling new patients. however, some countries/sites may still have paused the enrollment of new patients due to the pandemic. 24 april 2020: enrollment of new patients into this study has been paused due to the covid-19 situation. the duration of this pause is dependent on the leveling and control of the covid-19 pandemic.

Eligibility criteria:
inclusion criteria: * patients of any age or gender with confirmed diagnosis (biochemical and/or genetic) of gaucher disease * signed and dated written informed consent from the patient or, for patients aged \<18 years (\<16 years in the united kingdom \[uk\]), their parent and/or legally authorized representatives (lar), and assent of the minor where applicable. legally authorized representatives are also applicable for cognitively impaired patients. exclusion criteria: - patients currently enrolled in ongoing blinded clinical trials (drugs or devices; includes all blinded trials)
dysfunctional breathing, exercise capacity, and balance in hypertension

Conditions: Dysfunctional Breathing; Arterial Hypertension; Exercise Capacity; Balance

Summary: this prospective cross-sectional study aims to investigate the relationship between dysfunctional breathing (db), exercise capacity, and balance in patients with arterial hypertension (ht). db is characterized by abnormal breathing patterns and is associated with symptoms such as dyspnea and inefficient ventilation, regardless of the presence of organic respiratory disease. hypertension may further exacerbate these symptoms and contribute to impaired exercise performance and postural balance. the study will assess db using the nijmegen questionnaire, along with anthropometric measurements, balance tests, and functional exercise capacity evaluations. findings may contribute to better understanding of respiratory dysfunctions in hypertensive individuals and their impact on physical performance.


Eligibility criteria:
inclusion criteria: * aged between 18 and 70 years * diagnosed with hypertension and under follow-up for at least 6 months * willing to participate in the study voluntarily * nijmegen questionnaire score of 23 or above exclusion criteria: * medication change within the last month prior to study enrollment * presence of unstable metabolic disease
next day growth hormone predicting pituitary function after adenomectomy

Conditions: Hypopituitarism

Summary: this study tried to highlight the predictive value of the morning postoperative cortisol levels, which can act as the prognosis value of the postoperative pituitary function, providing future medication advices for improving patients' safety of drugs.

transsphenoidal adenomectomy usually accompanied by the failure or recovery of the pituitary gland, which usually causing further hypopituitarism and hormone recovery. in order to prevent the potential applications of adrenal cortical malfunction after the surgery, many medical centers will use glucocorticoid supplements during the perioperative period care. however, this treatment might expose the normal hypothalamic-pituitary-adrenal (hpa) axis function patients into potential threats after the treatment of glucocorticoid supplements, such as bone loss, hypertension, emotional distress, and weight gain. to avoid unnecessary supply of glucocorticoids, the key question is to monitor the pituitary function. thus, in this study we try to predict the morning postoperative cortisol levels, for further prediction of the postoperative pituitary function. to do so, we will review the retrospective charts of transsphenoidal adenomectomied patients from january, 2013 to april, 2018 in the ntuh taipei. use statistical methods analyzing all sorts of medical reports, including perioperative hormone thresholds.this study tried to highlight the predictive value of the morning postoperative cortisol levels, which can act as the prognosis value of the postoperative pituitary function, providing future medication advices for improving patients' safety of drugs.

Eligibility criteria:
inclusion: patients who had been treated with tsa were enrolled. exclusion: 1. hypopituitarism preoperatively. 2. acromegaly 3. multiple operations 4. incomplete hormone data or loss of follow-up

Keywords: hypopituitarism,pituitary function
stem cell derived exome for treatment of diabetic foot

Conditions: Diabetic Foot; Stem Cell

Summary: this trial is designed to investigate the safety and efficacy of patients with diabetic foot by using stem cell derived exome.

it is estimated that about 150 million people are suffering diabetes mellitus, of whom more than 15% will develop foot ulcers or gangrene at some times, so called diabetic foot. the diabetic foot is very difficult to cure by traditional approaches. this phase i clinical trial is designed to assess the safety and theraputical benefit of the stem cell derived exome.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of diabetic foot. 2. signed informed consent before recruiting. 3. age above 18 years or less than 90 years. 4. ecog score \< 4 5. tolerable coagulation function or reversible coagulation disorders 6. laboratory examination test within 7 days prior to procedure: wbc≥3.0×10e9/l; hb≥90g/l； plt ≥50×10e9/l；inr \ 28 g/l；total bilirubin \< 51 μmol/l 7. willing and able to comply with scheduled visits, treatment plan and laboratory tests. exclusion criteria: 1. patients participated in clinical trials of equipment or drugs (signed informed consent) within 4 weeks; 2. patients accompany by ascites, hepatic encephalopathy and esophageal and gastric varices bleeding; 3. any serious accompanying disease, which is expected to have an unknown, impact on the prognosis, include heart disease, inadequately controlled diabetes and psychiatric disorders; 4. patients have poor compliance. 5. allergic to the skin drug; 6. any agents which could affect the absorption or pharmacokinetics of the study drugs 7. other conditions that investigator decides not suitable for the trial.

Keywords: diabetic foot stem cell exome skin drug
therapeutic education in parkinson's disease: what impact on drug representations of patients? (etpark-remed)

Conditions: Parkinson Disease

Summary: dopaminergic drug can have adverse effects leading to potential serious consequences. therapeutic patient education must promote the understanding of drugs to improve its management. this study tries to evaluate the effect of therapeutic education workshop on parkinson disease's drug (drug workshop) on the evolution of drug's representations in patients with parkinson's disease compared to a control group.

dopaminergic drug can have adverse effects leading to potential serious consequences. therapeutic patient education must promote the understanding of drugs to improve its management. the therapeutic educational program etpark includes individual's consults or workshop. the team frequently offer to patients to participate in workshop on parkinson disease's drug. this study tries to evaluate the effect of therapeutic education workshop on parkinson disease's drug (drug workshop) on the evolution of drug's representations in patients with parkinson's disease compared to a control group (speaking group) at 1 and 3 months.

Eligibility criteria:
inclusion criteria: * patients with parkinson's disease according to the united kingdom parkinson disease society brain bank (ukpdsbb) criteria, * patients who are already in therapeutic education program etpark, * patients who need and want to participate in therapeutic education workshop on parkinson disease drug, * patients with health insurance, * patients who have signed a written informed consent form. exclusion criteria: * patients suffering from another parkinsonian syndrome (multiple system atrophy, progressive supranuclear palsy etc.), * patients who has already done workshop on parkinson disease drug (program etpark) * patients already included in clinical trial during the study, * patients who have severe psychiatric disorders or dopaminergic psychosis, * patients with cognitive impairment, * patients unable to complete the various scales used in the study, * patients under juridical protection, * women pregnant or breastfeeding.

Keywords: therapeutic education parkinson disease socials representations
early sequential nephron blockade in acute heart failure patients: a randomised, controlled study

Conditions: Acute Heart Failure; Acute Kidney Injury

Summary: this study aims to demonstrate the efficacy of sequential nephron blockade by adding hydrochlorothiazide or spironolactone on intravenous furosemide compared to intravenous furosemide alone in the treatments of volume overload in patients with acute heart failure who have diuretic resistance from furosemide stress test.

this study is a randomised, double-blinded, double-dummy, placebo-controlled study to demonstrate the efficacy of oral hydrochlorothiazide or spironolactone in combination with intravenous furosemide compared to intravenous furosemide in combination with placebo. dosage of intravenous furosemide will be adjusted according to pre-defined protocol. the primary outcome is urine volume during 72 hours after randomisation.

Eligibility criteria:
inclusion criteria: * age ≥18 years * diagnosis of acute heart failure which is defined by 2 of the 3 following features: ≥2+ leg edema, jugular venous pressure \>10 cm from physical examination or central venous pressure \>10 mmhg, and bilateral pulmonary edema or bilateral pleural effusion from chest radiography * patients consent to participate into the study exclusion criteria: * patients who receive furosemide ≥500 mg/day or hydrochlorothiazide ≥100 mg/day or spironolactone ≥100 mg/day or tolvaptan of any doses * patients who have systolic blood pressure \<100 mmhg or who need vasoactive drugs inotropic agents (except dobutamine) * patients with intravascular volume depletion from clinical evaluation * patients with chronic kidney disease stage 5 (estimated glomerular filtration rate \<15 ml/min/1.73 m2) or patients who receive maintenance dialysis * patients who require renal replacement therapy at the time of admission * patients whom diagnosed hypertrophic obstructive cardiomyopathy, severe valvular stenosis or complex congenital heart disease * patients with sepsis or systemic infection * pregnant women * patients who have history of furosemide, spironolactone or hydrochlorothiazide allergy

Keywords: acute heart failure diuretic resistance sequential nephron blockade diuretic combination
thyroid profiles in patients with acute illness

Conditions: Thyroid Dysfunction; Acute Illness

Summary: patients admitted to the hospital with acute illness may have a wide spectrum of thyroid function abnormalities. it is largely unknown whether such aberrations are temporary or persist for a long time, and whether they impact prognosis of such patients.

recently, there has been a growing body of evidence that subclinical thyroid dysfunction as a contributor to the increase of cardiovascular events. elevated serum thyroid-stimulating hormone (tsh) levels and normal free thyroxine (ft4) and free triiodothyronine (ft3) levels have been associated with worse heart failure and dyslipidemia. furthermore, higher risk of atrial fibrillation has been linked tp thyroid abnormalities in these patients. patients admitted to the hospital with acute illness may have a wide spectrum of thyroid function abnormalities. it is largely unknown whether such aberrations are temporary or persist for a long time, and whether they impact prognosis of such patients. this study aimed at evaluating the prevalence of thyroid function abnormalities in patients admitted to hospital with acute illness and their temporal changes and impact on mortality during hospitalization and at 1 year. serum level of thyroid stimulating hormone and free t4 and t3 measured on admission. clinical and laboratory profiles of patients with abnormal thyroid function (atf group) will be compared to those with normal thyroid function (ntf group). short and long term survival of both groups were compares as well.

Eligibility criteria:
inclusion criteria: * hospital admission * adults aged 18 years and above * willing to sign an informed consent * diagnosis on admission is acute illness that includes: heart failure, acute coronary syndrome, sepsis, acute stroke, hypotension, acute system-organ failure including renal and hepatic failure. exclusion criteria: * age less than 18 years. * refusal to sign consent. * admission for a reason not classified as acute illness.

Keywords: thyroid abnormalities acute illness prognosis middle east
pelvic neuromuscular facilitation and swiss ball exercises on trunk control in children with diaplegic cp

Conditions: Cerebral Palsy

Summary: cerebral palsy is an umbrella term that covers a group of non-progressive motor impairment syndromes that are associated with abnormalities in the brain particularly during the early stages of its development. cp usually involves a number of musculoskeletal and neurological problems they include spasticity, contractures, dystonia, abnormal growth, poor trunk control, and poor balance. poor trunk control leads to a disturbance in activities of daily living along with postural issues. pnf techniques and swiss ball exercises target the trunk muscles by stimulating the proprioceptors and by allowing maximum resistance to them respectively. the aim of the study is to do a comparison of pelvic neuromuscular facilitation techniques and swiss ball exercises in improving trunk control in children with diplegic cerebral palsy.

the studies conducted in the past were focused on finding out the effect of proprioceptive neuromuscular facilitation techniques on the lower extremities of children suffering from diplegic cerebral palsy. the effects of pnf on trunk control the children suffering from diplegic cp are nearly minimal. in addition to pnf, the literature shows that studies have been conducted to find the effects of swiss ball training exercise on trunk control of the post-stroke patients however there is very little research on the effects of swiss ball training in children suffering from diplegic cp. even if the studies are conducted the time duration of the studies are not enough to gain the maximum outcomes.

Eligibility criteria:
inclusion criteria: * patients with no trunk control * age between 5-12 years * patients with diplegia exclusion criteria: * patients with cognitive impairment * patients with comorbidities * patients who are unable to follow instructions

Keywords: cerebral palsy, trunk control training, proprioceptive neuromuscular facilitation approach, swiss ball, trunk control measurement scale.