Kornimate/medical-research-clean huggingface dataset:
early or delayed intervention of brain radiotherapy combined with almonertinib in egfr mutated nsclc with brain metastases

Conditions: Brain Metastases; Radiotherapy; EGFR Activating Mutation

Summary: this is a prospective, multicenter, randomized, controlled clinical study of nsclc patients with intracranial oligo-metastatic egfr-sensitive mutations treated with egfr-tki almonertinib , according to the implementation time of brain radiotherapy. patients were randomly divided into two groups, experimental group (early intervention group of brain radiotherapy) : the brain radiotherapy started within 1 month of tki treatment, the brain radiotherapy here specifically refers to stereotactic radiotherapy; control group (brain radiotherapy late intervention group) : brain radiotherapy was given within 3 months after brain progression during tki treatment. the differences in os,ipfs, pfs, iorr, safety, neurocognitive function and quality of life between the two groups were compared.


Eligibility criteria:
inclusion criteria: * patients with histologically or cytologically confirmed non-small cell lung cancer; * initial diagnosis of intracranial oligometastases (no treatment after brain metastases) was defined as brain parenchymal metastases confirmed by mri, the number of intracranial parenchymal metastases was less than 5, and the lesions were 3mm away from the optic nerve and brainstem; there must be at least one measurable lesion with a diameter of 5mm or more in the brain. * egfr sensitivity mutation (exon19del or exon21 l858r); * anti-egfr-targeting drugs and other tki drugs have not been used in the past; * age 18-75; inclusion criteria: * a history (past or concurrent) of malignancies in other sites, excluding curable non-melanoma skin cancer and cervical carcinoma in situ; * the subjects had received brain radiotherapy before enrollment; * patients whose lung lesions were surgically evaluated as resectable were not included if there was no metastasis in other parts of the body; * received egfr inhibitors (including small molecule or monoclonal antibody therapy) or systematic anti-tumor therapy before treatment; * prior patients with interstitial lung disease, drug-induced interstitial disease, radiation pneumonia requiring hormone therapy, or any clinically proven active interstitial lung disease with idiopathic pulmonary fibrosis found on ct scan at baseline; * pregnant and lactating patients; * mri contraindicated patients; * patients who cannot receive oral administration, need intravenous high-energy nutrition, have undergone previous surgery that interferes with absorption, or have active digestive tract ulcers; * the researchers judged that brain radiotherapy could not be received because of other head and facial diseases; * any unstable systemic disease (including active infection, poorly controlled hypertension, unstable angina, congestive heart failure, liver, kidney or metabolic disease).
absorptive clearance in the cystic fibrosis airway

Conditions: Cystic Fibrosis

Summary: the objective of this overall project is to develop a new aerosol-based technique for quantifying liquid absorption in the airways of subjects with cystic fibrosis(cf) that can be used to help develop new therapies. in cf, mutations in the cf gene result in dysfunction of the cystic fibrosis transmembrane conductance regulator (cftr) ion channel on the cells that line the airway epithelium, causing improper fluxes of ions such as sodium, chloride, and bicarbonate. the so called "low volume" hypothesis of cf pathogenesis contends that abnormal absorption of ions from the airways causes excessive absorption of liquid, resulting in an airway surface liquid layer that is dehydrated and difficult to clear. here we are measuring the absorption rate of a radiolabeled small molecule (dtpa) from the lungs of cystic fibrosis patients and healthy controls. we hypothesize that the molecule will absorb more quickly in cystic fibrosis patients. further studies will be performed to determine if dtpa absorption is related to liquid absorption in the airways.


Eligibility criteria:
inclusion criteria: * cystic fibrosis subjects and healthy controls * age ≥ 18 years * diagnosis of cystic fibrosis as determined by sweat test or genotype and clinical symptoms (cf subjects) * clinically stable as determined by the investigator (pulmonologist) exclusion criteria: * reactive airways disease * tobacco smokers (regular smoking within 6 months of enrollment) * positive urine pregnancy test on the day of testing * fev1p value of \< 50% * sao2 \< 92%, or if they require supplemental oxygen. * subjects performing other radioisotope studies within the last 2 weeks will be excluded. * healthy subjects with any history of lung disease will be excluded. * women currently breastfeeding * subjects not willing to stop treatments with inhaled hypertonic saline for 48 hours in advance of the study.

Keywords: cystic fibrosis mucociliary clearance outcome measures
work-related musculoskeletal disorders among otorhinolarngologists

Conditions: Work-Related Musculoskeletal Disorders Among EGYPTIAN Otorhinolarngologists

Summary: work-related musculoskeletal disorders among otorhinolarngologists

musculoskeletal disorders(msd) are one of the most common causes of occupational injuries and disability in industrialized nations and developing countries .with substantial financial consequences due to workers' compensation and medical expenses otolaryngology (pronounced oh/toe/lair/in/goll/oh/jee) is the oldest medical specialty in the united states. otolaryngologists are physicians trained in the medical and surgical management and treatment of patients with diseases and disorders of the ear, nose, throat (ent), and related structures of the head and neck. they are commonly referred to as ent physicians. msd were identified as a significant issue for the profession and research has recognized that msd in otolaryngology contribute considerably to sick leave, reduced productivity and leaving the profession because there are few studies available about msd among egyptian otolaryngologists so, the purpose of this study is to investigate musculoskeletal disorders among egyptian otorhinlaryngologist and the relationship between the risk factors and the development of musculoskeletal disorders among egyptian otolaryngologists

Eligibility criteria:
inclusion criteria: - otorhinolaryngologist in cairo university hospitals ,cairo teaching hospitasl will participate in the study. 1. general and specialized otolaryngologists will be included in the study. 2. both genders will be included in the study. 3. 1-20 years of experience. exclusion criteria: * otorhinologist will be excluded if : 1. they had musculoskeletal abnormalities due to other causes not work related (i.e. congenital,traumatic,neurological). 2. they had any systemic diseases such as uncontrolled diabetes, which may influence the musculoskeletal system 3. otolaryngologists with previous operation involving locomotors system.
management of pediatric pancreatic calculi at a single center: a retrospective cohort study

Conditions: Pancreatic Duct Stenting; ERCP; Surgery in Early Childhood; Pediatric Surgery

Summary: the goal of this observational study is to evaluate the long-term effects of ercp and surgery in pediatric patients with pancreatic duct stones. the main objective is to determine the optimal treatment choice(ercp or surgery) for children with pancreatic duct stones and identify the appropriate timing for surgery in patients who have undergone multiple ercp procedures, in order to avoid adverse outcomes caused by repeated trauma to the duodenal papilla. last updated on january 24, 2025.


Eligibility criteria:
inclusion criteria: * patients aged 0 to 18 years * diagnosed with pancreatic duct stones by imaging (e.g., ultrasound, ct, mrcp) * treated and followed at pediatric surgery, west china hospital, between 2014 and 2025 * complete clinical data available for review exclusion criteria: * pancreatic duct stones secondary to previous pancreatic or biliary surgery * concurrent severe systemic diseases (e.g., advanced cardiac, renal, or hepatic disease) * incomplete or missing key clinical records

Keywords: pancreatic duct stones ercp frey surgery
efficacy and tolerability of xalatan in patients

Conditions: Glaucoma; Ocular Hypertension

Summary: efficacy data was not collected or analyzed. this study did assess safety and tolerability of xalatan.

* efficacy data not collected or analyzed * safety and tolerability of xalatan assessed na

Eligibility criteria:
inclusion criteria: * patient with ocular hypertension at least 22mg hg * patient must be over 18 years old exclusion criteria: * none listed in the protocol

Keywords: observational safety study
brain enhancement training towards elders resilience to aging, phase iib

Conditions: Age-related Cognitive Decline

Summary: this study aims to examine the longer-term benefits of a novel, neuroplasticity-based, computerized and web-deliverable training program (pacr-ct) five years from the initial 10 weeks of training from our phase ii study - protocol #: psc-0605-17 (aim 1) and test the interactive effect of previous training and 10 weeks of booster training (aim 2). both the study and the software being investigated meet the criteria of non-significant risk.

this study will employ a single arm, open label design with use of the pacr-ct with all participants who completed the phase ii study, as well as approximately 60 new participants (with a goal of 40 completers) who are age-matched and untrained older adults. after consent, only the new, untrained participants will complete the screening visit. then all participants will perform the pre-training visit (cognitive and functional assessments, mri/fmri and blood draw), followed by 10 weeks of training, and then followed by post-training visit (cognitive and functional assessments and mri/fmri).

Eligibility criteria:
inclusion criteria: * participant must be 70 years of age or older * participant must be a fluent english speaker * participant must have adequate sensorimotor capacity to perform the program, including visual capacity adequate to read from a computer screen at a normal viewing distance, auditory capacity adequate to understand normal speech, and motor capacity adequate to control a computer mouse * participant must not have evidence of dementia as indicated by the montreal cognitive assessment (moca) exclusion criteria: * participant with any medical illnesses, injuries or conditions predisposing to imminent functional and/or cognitive decline * participant requiring caregiver assistance in dressing/personal hygiene * participant with severe visual deficits (including visual neglect, partial field cuts, anopias) and/or severe hearing deficit that would prevent use of the computerized treatment program * participant with recent participation of computer-delivered cognitive training within 2 years of consent * participant with claustrophobia or any other contraindication to mri scanning * participant with inability to complete a 1-hour mri * pregnant women * participant with any implanted devices above the waist (e.g., cardiac pacemaker or auto-defibrillators, neural pacemaker, aneurysm clips, cochlear implant, metallic bodies in the eye or central nervous system, any form of wires or metal devices that may concentrate radio frequency fields) * participants with active suicidal ideation with specific plan and intent or suicide-related behaviors within 2 months of consent as measured by the columbia-suicide severity rating scale (c-ssrs)
exercise intervention on cardiorespiratory function in hf with dm.

Conditions: Heart Failure

Summary: investigate the effects of exercise training on the cardiopulmonary function and exercise capacity in diabetes mellitus with heart failure.

this research intends to explore the effects of exercise training on the cardiopulmonary function and exercise tolerance of heart failure patients with diabetes mellitus. in addition to the impaired cardiac function, the clinical manifestations of patients with heart failure also shown the inefficiency of pulmonary function, peripheral vascular function, and musculoskeletal system. due to low exercise tolerance, functional activities and quality of life are impaired. with the high hospitalization rate and high mortality rate, the clinical treatment of heart failure is challenging. at present, exercise has been listed in the guidelines for the treatment of heart failure, and is recommended that patients with heart failure should take regular aerobic exercise training to maintain functional activity and reduce symptoms. past studies have also suggested that exercise training can help reduce the risk factors of cardiovascular disease and improve part of the cardiovascular function. furthermore, exercise can improve the quality of life and reduce the hospitalization rate. although diabetes is a common comorbidity of heart failure, and is a poor prognostic factor that increases the overall risk of heart failure and cardiovascular death, there are few studies in the past to further explore the benefits of exercise training for diabetes with heart failure, although current studies have confirmed that regular exercise can effectively control diabetes. however, the cardiopulmonary function and exercise tolerance of exercise training for diabetes with heart failure still need to be clarified. therefore, this study aims to investigated the effect of cardiopulmonary function and exercise tolerance in patients with heart failure. the study participants were divided into two groups: usual care group and exercise group. exercise training involved last for twelve weeks, and then follow up until the sixth week after exercise training. the results of the study are expected to be applied to clinical heart failure rehabilitation. it is expected that through active cardiopulmonary rehabilitation combined with precise and personalized exercise prescriptions, it will prevent deterioration of heart failure and may help improve the clinical practice of heart failure.

Eligibility criteria:
inclusion criteria: * heart failure (nyha i-iii) with diabetes mellitus * aged 30-85 * mini-mental state examination score \> 25 exclusion criteria: * egfr \< 30ml/min/1.73m2 * exercise intervention contraindication of heart failure * pregnancy * uncontrolled disease

Keywords: heart failure diabetes mellitus exercise intervention cardiac rehabilitation
cervical repositioning error in chronic migraine

Conditions: Migraine; Chronic Migraine

Summary: this study examines cervical joint position sense in individuals with chronic migraine vs. healthy controls. the ability to reposition the cervical spine after active movement will be evaluated in different head positions. impaired proprioception and motor control is hypothesized in the migraine group.


Eligibility criteria:
inclusion criteria: * individuals aged 18-65 years old * diagnosis of chronic migraine (for the chronic migraine group) * no history of migraine (for the control group) exclusion criteria: * history of cervical spine pathology * neurological deficits unrelated to migraine * current pregnancy
prevention and treatment of reperfusion injury after mechanical thrombectomy in acute ischemic stroke

Conditions: Stroke Patients

Summary: ischemic stroke accounts for 80% of all strokes and there is a lack of effective treatment options.mechanical thrombectomy can significantly improve the vascular recanalization rate and reduce the disability rate of stroke, but the problem of reperfusion injury caused by vascular recanalization is more prominent than before. the most common manifestation of reperfusion injury is postoperative hemorrhage transformation in the infarct area, which is caused by the inability of blood vessels to tolerate normal perfusion pressure after endothelial cell injury.therefore, in addition to using necessary strategies to reduce the risk of bleeding before and during surgery, maintaining an appropriate and individualized perfusion pressure after surgery is also an important strategy to prevent and treat postoperative bleeding. lead a multicenter, randomized, controlled study looking at individuation lowers blood pressure.( drop systolic blood pressure to 90-110mmhg，blood pressure not lower than 90/60 mm hg，the reduced blood pressure was maintained for 48 hours). influence of the incidence of hemorrhage transformation caused by reperfusion injury after mechanical thrombectomy and prognosis (modified rankin scale (mrs) score and proportion of patients with mrs≤2) at 48hours, 14 and 90 days after surgery.thus, provide clinical evidence for blood pressure management strategy after mechanical thrombectomy.


Eligibility criteria:
inclusion criteria: * patients with acute cerebral infarction with large vessel occlusion within 24 hours of onset .(internal carotid artery, m1 or m2 segment of middle cerebral artery, a1 segment of anterior cerebral artery). * 18 years≤age≤85 years. * ct ruled out cerebral hemorrhage and subarachnoid hemorrhage. * informed consent signed by patient or legal representative. * successful vascular recanalization (defined as modified thrombolysis in cerebral infarction (mtici)≥2b/3 for cerebral infarction with anterior bleeding). * degree of disease: 6 points≤nihss ≤19 points. exclusion criteria: * preoperative or immediate postoperative ct showed active bleeding or was known to have significant bleeding tendency \[international normalized ratio(inr)\>3.0,platelet count \<30×10 9/l. * severe heart, liver and kidney insufficiency. * blood glucose \ 22.2mmol/l. * severe hyperemia beyond medication control (\>180/105mm hg). * patients with alberta early stroke grading ct scores (aspect)\<6. * patients with a life expectancy of less than 90 days. * blood pressure is below 90/60 mm hg. * mrs≥3 points . * pregnant women.

Keywords: ischemic stroke mechanical thrombectomy blood pressure symptomatic bleeding transformation
a study of anginera in patients undergoing coronary artery bypass graft (cabg) surgery

Conditions: Coronary Artery Disease

Summary: this is a first in man, phase i safety study of anginera in adults with left ventricular dysfunction (lvd) and reversible myocardial ischemia undergoing a cabg procedure.

a prospective, multicenter, open-label phase i safety study of anginera. adults with left ventricular dysfunction and reversible myocardial ischemia who are undergoing a cabg procedure, who have at least one graftable vessel and at least one coronary vessel not amenable to bypass or pci (percutaneous coronary intervention)will be recruited. three pieces of anginera will be placed on the area of the surface of the ventricle, including the area supplied by the vessel or vessels that cannot be bypassed, as well as surrounding myocardium. patients will be followed for 12 months after the surgery at which anginera is implanted. the primary objective is to determine safety. the secondary objectives are to determine regional myocardial perfusion and regional left ventricular performance and to investigate the utility of measures of patient perception of improvement.

Eligibility criteria:
inclusion criteria: * patients have been referred for cabg * left ventricular ejection fraction (lvef) greater than 20% * patients have cad involving at least two (2) coronary arteries, with at least one or more vessel(s) having disease not amenable to bypass grafting or pci * there is a region of myocardium served by the vessel(s) defined above that has objective evidence of multi-distribution reversible ischemia based on a 17-segment assessment of reversible defects on spect/thallium. exclusion criteria: subjects meeting any of the following criteria will be excluded from the study: 1. patient undergoing valve replacement or valve modification 2. patient with significant or malignant ventricular arrhythmias, defined as a patient being treated for ventricular tachycardia and/or ventricular fibrillation with an implantable cardioverter/defibrillator (icd) or a patient being treated with amiodarone for these same tachyarrhythmias. (note: having an implantable cardioverter/defibrillator (icd) per se, in a patient who does not have significant or malignant ventricular arrhythmias, does not exclude the patient from this study.) 3. patient requires urgent coronary artery bypass surgery

Keywords: cabg anginera cad
sympathetic nerve activity and an implantable cardioverter defibrillator in heart failure patients

Conditions: Heart Failure; Death, Sudden, Cardiac

Summary: the aim of this study is to analyze whether the sympathetic tone, measured indirectly and directly by muscle sympathetic nerve activity recording, is elevated in patients with heart failure receiving an appropriate shock from their implantable cardiac defibrillator (icd) compared to heart failure patients not receiving a shock from their icd. all parameters measured in this study will be used to build a risk algorithm able to identify heart failure patients at high risk for sudden cardiac death who could receive an icd.

we plan to perform an extensive study of the sympathetic nervous system activity in heart failure patients with an icd. the sns activity will be measured directly by a recording of the muscle sympathetic nerve activity and indirectly by post processing of 24-hour holter recording, catecholamine levels assessment, and spontaneous baroreflex sensitivity. a global assessment of the patients status will also be realised. patients will be followed for one year. during follow up, this cohort will be divided into two groups according to the occurrence or not of an appropriate shock. we assume that an appropriate shock is a surrogate marker for sudden cardiac death. we plan to compare the autonomic nervous system activity in both groups of patients in order to identify a score able to detect heart failure patients at high risk for sudden cardiac death.

Eligibility criteria:
inclusion criteria: * heart failure patient with an icd exclusion criteria: * pregnant patient * acute coronary syndrome within the last 3 months * peripheral neuropathy.

Keywords: implantable cardioverter defibrillator heart failure sudden cardiac arrest appropriate shock defibrillators, implantable
imaging dopamine function and its impact on outcome after traumatic brain injury (tbi)

Conditions: Traumatic Brain Injury

Summary: this study will examine resting dopamine function as well as dopamine response in the brain as it interacts with medicines normally prescribed to subacute traumatic brain injury (tbi) patients.


Eligibility criteria:
inclusion criteria: * non-penetrating tbi * age between 18-50 years old * admitted to a north texas tbi model systems-affiliated rehabilitation facility within 16 weeks of injury * rated at rancho vi los amigos levels of cognitive functioning scale of less than or equal to stage v at the time of enrollment * disability rating scale total score \>/= 7 exclusion criteria: * central nervous system disorder resulting in functional disability predating tbi * documented diagnosis of disease processes impacted by the dopamine system (e.g., parkinson's disease, clinician diagnosed attention deficit hyperactivity disorder, substance abuse/dependence (excluding marijuana, alcohol, tobacco), or schizophrenia) * pre-injury use of dopaminergic pharmaceuticals (i.e., methylphenidate, amantadine, or dopamine receptor blockers such as olanzapine or quetiapine) * documented contraindication to use of methylphenidate including allergy * uncontrolled epilepsy * pregnant * medical condition not compatible with use of methylphenidate * recent diagnosis or therapeutic study using radiopharmaceuticals * contraindications to the use of ioflupane * allergic to iodine

Keywords: tbi