Kornimate/medical-research-clean huggingface dataset:
ehealth for screening health risks in home-based older adults: a prospective study

Conditions: Frail Elderly Syndrome; Older

Summary: introduction: due to the worldwide ageing population and the increasing prevalence of chronic illnesses and cognitive deficits, appropriate instruments for frailty early screening and assessment of geriatric syndromes are required. digital tools based on artificial intelligence can help improve the evaluation and screening of health risks in the older adults. objectives: this study aims to evaluate the effectiveness of the presage care questionnaire in screening geriatric syndromes among older adults and to assess its correlation with standardized test scores of the comprehensive geriatric assessment (cga). methods: a monocentric prospective observational study will be conducted between october 2023 and july 2024, on seniors who are in the day hospitalization service of charles-foix hospital in france. during the consultation with older adults, the investigators will ask the patient's home caregiver to use the presage care application to fill in the presage care questionnaire. once the questionnaire will be completed on the application, the presage platform will automatically recorde specific risks for each senior. subsequently, the investigators will retrieve the data from standardized tests conduct on the same day and enter the results for each patient into the platform. the primary outcome will be the correlation between standardized test scores and the risks computed by the presage care system for the risk of depression, the risk of undernutrition, the risk of cognitive impairment and the risk of loss of autonomy in activities of daily living. secondary outcome will be the comparison of the area under the median curve (auc), and the sensitivity, specificity and positive predictive values of artificial intelligence (ai)-based models on the présage care questionnaire.

during the consultation and the assessment of the older adult by the physicians and the nurses at the day hospitalization service of the hospital, patient's relative fill out presage care questionnaire. then, the investigators retrieved the data from the standardized tests completed the same day by the health professionals and filled in the test results for each patient on the platform.

Eligibility criteria:
* inclusion criteria : 1. family members of individuals aged 65 and above, 2. who are present within the day hospitalization service of charles-foix hospital 3. and able to provide informed consent. * non inclusion criteria 1. refuse to give their consent to participate in the study, 2. or have cognitive impairments 3. or are occasional caregivers.

Keywords: screening tool prevention artificial intelligence geriatric syndromes
high dose versus routine dose icotinib in advanced non-small cell lung cancer patients with stable disease

Conditions: Non-small Cell Lung Cancer

Summary: we hypothesize that higher dose icotinib is related with better efficacy. the primary objective is to compare the progression-free survival of higher dose and routine dose of icotinib in treating pretreated advanced non-small cell lung cancer patients with stable disease after 8-week routine dose icotinib treatment.


Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed stage iiib/iv lung cancer(exclude patients confirmed by sputum cytology); * pretreated with at least 1 platinum-based chemotherapy; * no previous targeted treatment such as gefitinib, erlotinib; * with a measurable disease(longest diameters \>=10mm with spiral computed tomography (ct)and \>=20mm with conventional ct) according to recist criteria; * who performance status(ps)\<= 2; * adequate organ functions; * signed and dated informed consent before the start of specific protocol procedures. exclusion criteria: * allergic to icotinib; * patients with metastatic brain tumors with symptoms; * experience of anti-egfr(the epidermal growth factor receptor) monoclonal antibody or small molecular compounds therapy such as gefitinib, erlotinib or cetuximab; * severe systemic disease out of control such as unstable or uncompensated respiratory,cardiac,liver,renal diseases.
financial toxicity and patient-reported outcomes in gep-nen during treatment

Conditions: Neuroendocrine Tumors

Summary: the aim of this study is to evaluate the financial toxicity reported by italian patients affected by gep-nen during the first year of treatment after diagnosis and its correlations with patient-reported outcomes (pros) and quality of life (qol).

gastroenteropancreatic neuroendocrine neoplasms (gep-nen) are rare tumours whose incidence has increased during the years. however, referral centers specialized in diagnosis and treatment of these diseases are few. so, patients may be forced to travel long distances in order to reach a disease specialized center (enets certification) to plan the correct management and receive the better treatment. on the other hand, patients could research different clinical consulting by several medical specialists without clear indication. moreover, today also advanced disease allows the patients a good prognosis with long survival. the resulting emotional and psychological burden may contribute to the worse quality of life. therefore, patients with gep-nen have a deal with the financial consequences related to the diagnosis and treatment of their disease including out of pocket costs, loss of income and caregiver burden. financial toxicity, defined as subjective financial concerns of cancer and objective financial consequences, has been investigated in this study in italian patients affected by gep-nen

Eligibility criteria:
inclusion criteria: * ≥18 years of age * new diagnosis of gastroenteropancreatic neuroendocrine neoplasms (gep-nen) * patients who are candidates for surgical and/or medical treatment \[including somatostatin analogues (saa), peptide recector radionuclide therapy (prrt), target therapies (everolimus or sunitinib) and chemotherapy\]; * signed informed consent exclusion criteria: * age \< 18 years * patients diagnosed with gep-nen who are candidates for a surveillance management. * patients diagnosed with gep-nen who are candidates for best supportive care and/or have a life expectancy \< 6 months.

Keywords: gep-nen financial toxicity quality of life costs
outcomes of phacoemulsification with torsional ultrasound

Conditions: Cataract

Summary: to determine the differences in intra-operative complications, surgical duration, fluid usage, corneal thickness and endothelium cell density in eyes undergoing microcoaxial phacoemulsification (mcp) either with torsional or longitudinal ultrasound during the surgery and at post-operative day 1, 1 month and 3 months.

introduced in mid 2006, torsional ultrasound (ozil, infiniti vision system, alcon laboratories, texas, usa) uses rotational oscillations at ultrasonic frequencies to emulsify cataractous lens material in a seamless cutting motion from a tip that oscillates laterally. the side-to-side movement of the phaco tip produces minimal repulsion of lens material from the phaco tip resulting in improved followability. clinically this translates into more effective lens removal with torsional phaco in comparison to the conventional ultrasound mode.to test this in a clinical scenario we undertook this study.

Eligibility criteria:
inclusion criteria: * patients 55 years and older with a senile cataract grades 1 to 5 nuclear sclerosis based on emery's classification, * endothelial cell density \> 1500 cells/mm2, * anterior chamber depth \> 2.4 mm, and * a dilated pupil \> 7 mm. exclusion criteria: * eyes with pseudoexfoliation, * mature, traumatic, or complicated cataracts, * history of previous intra-ocular surgery, glaucoma, uveitis, and * patients who were unable to comply with follow-up examinations.

Keywords: pachymetry cell loss safety efficacy phacoemulsification intraoperative complications clock time fluid used corneal thickness endothelium cell loss
effects of postural balance exercises in patients with heart failure

Conditions: Heart Failure; Systolic Heart Failure; Diastolic Heart Failure

Summary: in this study, the effects of core stabilization and computerized wobble board exercise training programs on postural balance and functional exercise capacity in patients over 60 years of age with heart failure will be investigated.

this study will consist of core stabilization group (csg), wobble board group (wbg) and control group. in csg, exercises that focus basically on the abdominal, pelvic floor, trunk extensor and diaphragm muscles and comply with core stabilization criteria will be applied. in wbg, balance exercises which focus primarily lower limb and trunk muscles, will be performed on computerized wobble board with visual feed-back provided by computerized wobble board. in control group, no exercise will be performed, only the evaluation procedure will be applied at the beginning and 8 weeks later. it was planned to include in total of 36 patients and will be randomized them into three groups with 12 patients. following the initial assessment, each patient will participate in a one-session patient education program. after that, patients in csg and wbg will participate in their exercise training program which supervised by physiotherapist, 3 days a week for 8 weeks.when the exercise training programs for 8 weeks were completed, initial evaluations will be re-applied. collected data will be analyzed with spss 22.0 (ibm corp., armonk, ny, usa) program. the differences between pre- and post-treatment evaluations will be analyzed with "paired t test" and/ or " wilcoxon test".the differences between three groups will be analyzed with one-way analysis of variance and/ or kruskal-wallis test.

Eligibility criteria:
inclusion criteria: * 60 years and older * patients with heart failure who diagnosed by cardiologist * patients have stable drug therapy and to be clinically stable at least last three months * patients who signed the informed consent form exclusion criteria: * history of myocardial infarction in the last 6 months * acute coronary syndrome * un-controlled diabetes and/ or hypertension * severe valvular heart disease and/ or arrhythmia * having a pacemaker * severe cognitive disorder * severe orthopedic and/ or neurological problem * visual or auditory impairment * walking with device

Keywords: wobble board core stabilization balance training functionally capacity heart failure
breastfeeding duration and tongue-tie in neonates.

Conditions: Infant Nutrition Disorders

Summary: the goal of this observational study is to examine how performed frenotomy in term-born infants influences the breastfeeding duration. the main questions the study aims to answer are how a suspected tongue-tie, vacuum strength, and breastfeeding may be associated. families of infants with tongue-tie where frenotomy is suspected will be invited to participate. intra-oral vacuum measurements before and 5-10 days after frenotomy will be obtained and the breastfeeding status followed for 6 months.

exclusive breastfeeding is defined as feeding the infant with human breast milk only, except for vitamins, minerals supplements and medicine. it is an official recommendation that infants are exclusively breastfed for 6 months. approximately 60% and 15% of danish infants are exclusively breastfed for 4 and 6 months respectively. there are many factors that may interfere with the establishment and duration of breastfeeding. for the infant, breastfeeding depends on the infant´s ability to seal the oral cavity around the breast and integrate the muscular activities of cheeks, lips, jaw, and tongue. effectively nutritive sucking occurs due to the application of positive pressure when the tongue moves upwards to express milk, followed by an intra-oral vacuum (vacuum) when the tongue moves downwards and draws milk from the breast by suction. the strength of vacuum affects the effectiveness of milk removal from the breast and regulates the volume of milk. a weak vacuum may, therefore, lead to a shortage of milk transfer, diminished milk supply and early breastfeeding stop. conversely, was in a recently published study found an association between a high vacuum and infants who were exclusively breastfed for the recommended 6 months. difficulties in creating an appropriate vacuum may be related to ankyloglossia, tight frenulum also called tongue-tie, a condition in which the lingual frenulum has anterior attachment near the tip of the tongue and/or are unusually thick, tight, and/or short lingual frenulum. tongue-tie is often detected when the infant shows signs of difficulties during breastfeeding and/or there is maternal nipple pain. the possible consequence of tongue-tie is insufficient infant weight gain, neonatal dehydration, and shortened breastfeeding duration. in case of breastfeeding difficulties, it is recommended to evaluate the tongue-tie by the breastfed babies assessment tool score (tabby) and depending on this assessment frenotomy may be recommended. the value of both the tabby score and frenotomy is only poorly validated. hypothesis we hypothesise vacuum to increase after frenotomy and, thereby, affect breastfeeding duration positively.

Eligibility criteria:
inclusion criteria: infant of an adult mother delivery after 37 completed gestational weeks. singleton or twin infant of a mother who intends to breastfeed. at least one parents speak and write english, danish, norwegian, or swedish. exclusion criteria: congenital malformation. reduced lung function.

Keywords: ankyloglossia frenotomy infants intra-oral vacuum breastfeeding
using virtual reality (vr) technology in gynecological and obstetrics procedures

Conditions: Virtual Reality; Anxiety; Pain

Summary: a randomized control trial will be conducted in assuta ashdod hospital, in the department of obstetrics and gynecology. pregnant and non pregnant women, undergoing one of the procedures (external cephalic version,amniocentesis or hysteroscopy), will be approached. all willing patients meeting the criteria will sign an informed consent form will. after signing informed consent patients will be randomly allocated into three groups:1) control (no use of vr). 2) use of vr googles without positive psychology. 3) use of vr googles with positive psychology. before and after the procedure each group will answer pain and anxiety questionnaires. in addition, following, following each procedure, salivary cortisol levels will be measured.


Eligibility criteria:
inclusion criteria: * ecv- single tone, breech presentation,gestional age 35-40,unknown drug allergy * amniocintesis -single tone,gestional age 16-24 week, * hysteroscopy-women age 18-60 , diagnostic procedure, exclusion criteria: * ecv-previous cesarian section, contruction,low known plt count ,premature rupture of membrane * amniocintesis- known fetal malformations, amnionitis * hysteroscopy-pregnancy, pid
effect of aging on bariatric surgery-induced changes in metabolism and cognition

Conditions: Insulin Resistance; Cognitive Impairment

Summary: the investigators hypothesize that the improvements in insulin sensitivity, beta (β)-cell function, and inflammation will be greater, and the improvement in sarcopenic obesity will be less, in younger versus older individuals after substantial weight loss induced by sleeve gastrectomy bariatric surgery.

with an aging population that is increasingly susceptible to obesity and obesity-related comorbidities including sarcopenia and diabetes, effective and safe treatment options tailored to the needs of older adults are imperative. while medication and lifestyle interventions generally fail to achieve sustained large-scale weight loss, bariatric surgery is the most effective long-term weight loss treatment for obese patients and improves many of the medical complications associated with obesity. sleeve gastrectomy (sg) results in substantial weight loss and may be more appropriate for older adults due to its low rate of complications and mortality. therefore, sg has been proposed as a reasonable primary treatment modality in older obese individuals, with a substantial recent increase in the number of interventions performed. despite the potential benefits, very little is known of the physiologic and metabolic effects of bariatric surgery, including sg, on glucose homeostasis and muscle physiology in older adults. a fundamental understanding of the effects of excess adiposity and weight loss interventions is of profound importance, especially with emerging evidence that earlier treatment of obesity may delay/prevent many comorbidities. an underlying inflammatory state has been implicated in the pathogenesis of sarcopenia and insulin resistance and may provide an important connection to the age-related declines seen in older obese patients. therefore, this study aims to evaluate the modifying effect of age and inflammation on the sg-induced changes in body composition, muscle physiology, and insulin sensitivity. this protocol will be conducted in two age cohorts (greater than 60 and less than 50 years old).

Eligibility criteria:
inclusion criteria: * age 21-80 yrs old * bmi ≥ 35 kg/m2 * undergoing laparoscopic sleeve gastrectomy (sg) exclusion criteria: * smokers * presence of diabetes mellitus * taking any medication that might affect metabolism * severe organ dysfunction * pregnant or breastfeeding * prior gastrointestinal surgery that might affect study results * unable or unwilling to follow the study protocol or any reason the research team believes the subject is not an appropriate candidate for this study * weight \>450 pounds (will be unable to fit on the dxa scanner)
effects of low-intensity strength training with concomitant blood flow restriction on pain perception in patients with anterior cruciate ligament surgery

Conditions: Anterior Cruciate Ligament Injury

Summary: after surgical treatment of a tear of the anterior cruciate ligament, physiotherapeutic exercises are done as standard therapy. this is to achieve a rapid improvement in pain and knee function. in this study, the investigators examine how low-intensity strength training with simultaneous restriction of blood flow works and whether it is effective and well tolerated. for this purpose, a pressure cuff is applied to the leg during training. participation in this study will last four weeks for each participant. the investigators will invite participants for 11 study visits. one appointment will last about 30 minutes. if a participant decides to take part in the study, they will be randomly assigned to one of two groups. the participants will belong to either an experimental group or the control group. in the experimental group, the participants will be treated with the intervention method. the intervention method involves 4 weeks of low-intensity strength training with an additional pressure cuff on the leg, which should lead to improved adaptations to the muscle as well as a reduction in pain. in the control group, the participants will receive the same strength training only without the additional pressure cuff. the benefit is that in addition to the participants actual rehabilitation program, each participant will receive free training to build their muscles. this could contribute to an accelerated rehabilitation process and a faster build-up of strength as well as an improvement in pain. it is additionally possible that the participants will help future patients with their participation. the intervention method for strength training with simultaneous restriction of blood flow (blood flow restriction training) has been studied for some time. there is good evidence of improved muscle, tendon and pain adaptations in both healthy individuals and patients with acl injury. whether this training method also has an effect on pain perception will be investigated in this study. participants may experience side effects if they are treated with the intervention method (low-intensity strength training with simultaneous restriction of blood flow). the investigators may not yet know all the risks and side effects of the intervention method. so far, the following risks and side effects are known: * temporay numbness * muscle soreness * pressure sensation


Eligibility criteria:
inclusion criteria: * it must be your first anterior cruciate ligament surgery * you must be between 18 and 60 years old * you must be able to successfully complete certain exercises * the injury must have occurred no longer than 6 months ago exclusion criteria: * injury in other ligaments in the knee and cartilage * thrombosis * infection * high blood pressure (which is not treated with medication)

Keywords: acl injury bfr blood flow restriction physiotherapy
clinical characteristics of aquagenic pruritus in patients with myeloproliferative neoplasms

Conditions: Myeloproliferative Disorder

Summary: description of the characteristics of aquagenic pruritus expressed by patients suffering from myeloproliferative neoplasms. prospective work based on the distribution of a dedicated questionnaire.

patients with myeloproliferative neoplasms identified and followed in our institution (brest university hospital). patients could be followed for polycythemia vera or essential thrombocythemia or myelofibrosis. distribution of the questionnaire to each patients with myeloproliferative neoplasms (treated or not) suffering from aquagenic pruritus. analyse of each characteristic of the aquagenic pruritus by a statistician and publication at the end.

Eligibility criteria:
inclusion criteria: * patients followed with myeloproliferative neoplasms * suffering from aquagenic pruritus exclusion criteria: * unable to fulfil the questionnaire * no written informed consent

Keywords: aquagenic pruritus
disease-modifying antirheumatic drugs cycle combination therapy research

Conditions: Rheumatoid Arthritis

Summary: this study was intended to assess the efficacy and safety of different disease-modifying antirheumatic drugs cycle combination regimen using the american college of rheumatology (acr) criteria of 20% improvement in symptoms (acr20) in managing active adult rheumatoid arthritis.


Eligibility criteria:
inclusion criteria: ra patients： * male and female patients aged 18 - 75 years (inclusive). * body weight between 50 and 100 kg (inclusive). * post menopausal or surgically sterile female patients are allowed. female patients of child-bearing potential may participate if they are already on a stable dose of methotrexate. additional birth control details to be provided at screening. male patients must use an effective contraception method during the study and at least for 2 months following the completion/discontinuation of the study. * diagnosis of ra, classified by american rheumatism association 1987 revised criteria. * active disease evaluation (das 28 \> 3.2). * patients who using steroids before enrollment, the dose should not be more than 30mg/d, and remain unchanged for more than 30days. * without use of other disease activity controlling drugs. * get the informed consent. exclusion criteria: * advanced patients with severe joints disability. * pregnant or breast- feeding female patients. * patients with severe primary disease or impairment of heart, brain, lung, liver (alt or ast \> 1.5 normal value), kidney (scr \> normal value), endocrine, and hematology system. * concomitant with other rheumatic disease. * alcohol taken or drug abusing patients. * patients with congestive heart failure, qt prolongation syndrome or poorly controlled diabetes mellitus. patients with a history of qtc prolongation will be excluded. * patients who have received intra-articular or systemic corticosteroid injections having been required for treatment of acute ra flare (not being part of a regular therapeutic regimen) within 4 weeks prior to randomization.

Keywords: ra leflunomide methotrexate