Kornimate/medical-research-clean huggingface dataset:
biomarkerscreening in cervical cancer and its preinvasive lesions

Conditions: Evaluation of New Tissue Biomarkers for Cervical Cancer

Summary: the following trial is a multicenter and prospective research trial of the colposcopy unit of luebeck university and the national research center in borstel, germany. the study is to identify and evaluate new biomarkers in human papilloma virus (hpv) associated malignancies and its preinvasive lesions of the cervix uteri. fresh tissue samples being removed during conizations and/or hysterectomies are to be fixed in hope's solution and analyzed according to their transcriptomes and methylosome. the hereby found candidates are to be validated using immunohistochemistry and rt \[real-time\] -pcr \[polymerase chain reaction\]. the project is meant to be followed by continuous studies developing a new test describing the malignant potential of hpv associated genital lesions.


Eligibility criteria:
inclusion criteria: * positive informed consent * patients with suspected preinvasive genital lesion * patients with confirmed genital lesion (both preinvasive and invasive) * contact via dept. of obs/gyn of luebeck university * complete set of data exclusion criteria: * incomplete set of data * negative informed consent
evaluating changes of spino-pelvic radiological parameters during muslim prayer positions

Conditions: Spinopelvic Relatiohship; Spinopelvic Parameters Change During Praying Positions

Summary: this observational study aims to investigate the spinopelvic relationship parameters change during the five main positions during muslim prayers. the main questions the study is going to answer: what are the changes of the spinopelvic parameters during different muslim prayer positions?

the spinopelvic relationship refers to the intricate and dynamic interaction between the spine and the pelvis, which plays a crucial role in maintaining posture, balance, and overall musculoskeletal function. the alignment and movement of the spine and pelvis are interdependent, with changes in one structure often influencing the other. understanding this relationship is essential for diagnosing, managing, and treating various spinal and pelvic conditions; furthermore, these parameters profoundly affect acetabular cup positioning and could affect dislocation rate after total hip arthroplasty. evaluating the normal spinopelvic parameters for any particular population is the first step toward detecting abnormal relationships, these were evaluated in various populations, such as indian, brazilian, korean, and caucasians. besides the deficiency of such reports from our area (middle east), most of the published reports evaluated the change in spinopelvic relationship by evaluating the differences occurring from standing to 90 degrees sitting positions, which ignores most of the positions occurring during muslim prayer, which necessitates more flexion of the hips and spine during specific position such as prostration (sujud). activities that involve dynamic movements, such as muslim prayer positions, can influence spinopelvic parameters. the sequence of postures in muslim prayers, which includes standing, bowing, and kneeling, places unique demands on the spinopelvic alignment. understanding how these positions affect spinopelvic parameters is essential for providing insights into the potential implications for musculoskeletal health, particularly in populations that engage in these activities regularly; furthermore, the possibility of proceeding with prayers after tha surgery if the dislocation risk due to impingement is low. what are the changes of the spinopelvic parameters during different muslim prayer positions and if these changes are different between males and females and if these parameters are affected by participants' body habits, mainly the body mass index (bmi).

Eligibility criteria:
inclusion criteria: adult participants (18 to 55 years old) who are willing to volunteer to participate in the study, reporting performing prayer positions without difficulty, had no hip or spine surgeries or complaints (pain or stiffness) exclusion criteria: * participants refusing to volunteer. * participants who are not able to perform prayer positions comfortably. * those who had prior spine or hip surgeries.

Keywords: spinopelvic relationship pelvic incidence pelvic tilt sacral slope lumbar lordosis
comparison of the immune response to natural covid-19 infection and vaccination

Conditions: Covid19

Summary: the ongoing coronavirus disease 2019 (covid-19) pandemic has been intensified by no population-based immunity to the severe acute respiratory disease coronavirus 2 (sars-cov2) and initially lack of effective treatments or vaccines available to mitigate the pandemic. currently, two covid-19 vaccines are available for vaccination in europe through conditional marketing authorisation granted by the european medicines agency and further vaccine will be licensed. these vaccines have shown good vaccine efficacy in phase 3 vaccine trials. we will recruit subjects who will be prioritised for vaccination with the primary aim of comparing the immune responses after covid-19 vaccination and natural sars-cov-2 infection. in western norway we have recruited cohorts of health care workers and patients infected with sars-cov-2 and will extend to covid-19 vaccinees. demographic, clinical data and repeated blood samples will be collected to evaluate the complications and kinetics, duration and breadth of the immune responses comparing natural infection to vaccination.

the primary aim of this study is * to compare immune responses after natural sars-cov-2 infection and covid-19 vaccination the secondary aims are * to compare the duration and breadth of antibody responses between natural infection and vaccination. * to investigate the duration and breadth of b and t cellular responses between natural infection and vaccination. * to evaluate the short and long term complications after natural infection and vaccination. * to find out if previous infection skews the immune response after vaccination. * to study reinfection after natural infection and vaccination.

Eligibility criteria:
inclusion criteria: * subjects prioritized by national vaccination program exclusion criteria: * children * unable or unwilling to provide informed consent

Keywords: covid19 vaccine sars-cov-2 antibody
post- end- expiratory pressure affect the alveolar heterogeneity in moderate and sever ards patients

Conditions: Ards

Summary: this study try to use eit ( electronic impedance tomography ) to evaluate the alveolar heterogeneity and use trans-pulmonary pressure and stain to evaluate the lung injury . the study use these methods to figure out how peep impact the alveolar heterogeneity and vili.

ards(acute respiratory distress syndrome )is common in patients suffering sepsis, trauma, burning and other sever condition and characterized by diffuse alveolar damage and alveolar heterogeneity.ards patient need mv(mechanical ventilation )to maintain oxygenation and need unique mv tragedy to avoid vili(ventilator induced lung injury ).peep(post-end-expiratory pressure) is crucial to maintain oxygenation and avoid vili according to researches. but there are also some other research different voice. this study try to use eit ( electronic impedance tomography ) to evaluate the alveolar heterogeneity and use trans-pulmonary pressure and stain to evaluate the lung injury . the study use these methods to figure out how peep impact the alveolar heterogeneity and vili.

Eligibility criteria:
inclusion criteria: 1. age≥18 or\<80； 2. moderate or sever ards in 2012 \ ; 3. applied mechanical ventilation; 4. consent signed. exclusion criteria: 1. asthma or copd； 2. cardiogenic edema； 3. sever neutropenia(\<500/mm3)； 4. hemodynamic astatic: dopa or dobutamine \>15 µg/kg/ min; ne \> 15ug /min； 5. gcs coma score ≤12； 6. thoracic injury or surgery patients contradict eit ； 7. refuse to join in trail； 8. included in other clinical trail。

Keywords: ards（acute respiratory syndrome）; stress; strain; trans-pulmonary pressure; frc(functional residual capacity ) peep（post end-expiratory pressure）; eit（electronic impedance tomography）; rvd(region ventilation delay)
long-term follow-up of living liver donors: a single-center experience

Conditions: Liver Transplantation

Summary: data on the long-term consequences of living liver donation are scarce. this study examined clinical, laboratory, and radiological parameters and long-term health-related quality of life (hrqol) in 237 living liver donors and 239 matched controls during 48 to 168 months of postdonation follow-up.

data on the long-term consequences of living liver donation are scarce. this study examined clinical, laboratory, and radiological parameters and long-term health-related quality of life (hrqol) in 237 living liver donors and 239 matched controls during 48 to 168 months of postdonation follow-up. we used the 36-item short-form health survey (short form-36 health survey, version 1 \[sf-36\]). the scores for the 4 following subscales were higher in nondonors than in donors: physical functioning (p = 0.009), role limitations due to physical health (p = 0.002), energy/fatigue (p \< 0.001), and bodily pain (p \< 0.001). the scores on the 8 subscales of the sf-36 were higher in donors with living recipients than in donors whose recipients died (p \< 0.001). our results suggest that living donor right hepatectomy is safe and results in a postdonation hrqol similar to that of nondonors in those donors whose recipients are healthy, while donors whose recipients die have a lower hrqol that is significantly negatively correlated with the time since recipient death and improves over time.

Eligibility criteria:
inclusion criteria: * age 18-50 years * no comorbidities. * bmi less than 30 kg/m2. * compatible abo group. exclusion criteria: * older than 50 years. * associated comorbidities. * obesity. * noncompatible abo group.

Keywords: living-donor liver transplantation quality of life follow up
effect of celecoxib on transitional pain after outpatient surgery

Conditions: Pain

Summary: sixty adults having shoulder and forearm surgery will receive either placebo or celebrex started preoperatively and continued for 3 days. rescue medications required as well as pain scores will be assessed using a patient diary to evaluate the effect of celebrex in controlling transitional pain


Eligibility criteria:
inclusion criteria: * patients scheduled for elective ambulatory surgery of the shoulder * asa i - iii * able to read english * male or female exclusion criteria: * allergy to local anesthetic, cox2, sulpha drug, acetaminophen or oxycodone * women who are pregnant or lactating and women of childbearing age and not following acceptable contraceptive precautions * any major medical or psychiatric problem * those with a known history of narcotic dependence, abuse or chronic narcotic intake * patients with known history of peptic ulcer or gi bleeding in the past, ulcers, congestive heart failure, angina or previous heart attack, coagulation problems, venous thrombosis, kidney or liver disease or strokes

Keywords: shoulder surgery analgesia
preasthmacontrol (pac)

Conditions: Asthma

Summary: the purpose of this study is to investigate the ability of budesonide, given during episodes of troublesome lung symptoms to reduce further symptoms in infants and young children at risk of developing asthma


Eligibility criteria:
inclusion criteria: * children of asthmatic mothers form the copsac birth cohort study exclusion criteria: * children born more than 4 weeks preterm * children with other systemic illness that atopy/allergy * children requiring mechanical ventilation at any time since birth.
pharmacokinetic study of vancomycin, clindamycin and/or gentamicin administration during surgery using a microdialysis procedure

Conditions: Surgical Site Infection

Summary: the surgical site infection is one of the most important causes of postoperative morbidity. the appropriate antibiotic prophylaxis is one of the most effective way to prevent surgical site infections. the beta-lactam are the most frequent antibiotics recommended for surgical prophylaxis and patients known to be allergic to beta-lactam are more likely to presented surgical site infection, probably due to use of others antibiotic such as vancomycin or clindamycin. the main objective of the study is to describe the tissu and plasma pharmacokinetics of vancomycin, clindamycin and gentamicin using as surgical antibiotic prophylaxis in patients with beta-lactam hypersensivity and to predict the probability of target attainment for usual bacteria.


Eligibility criteria:
inclusion criteria: * adult patient between 18 and 80 years old * patient with history of beta-lactam hypersensitivity * patient who underwent abdominal or orthopedic surgery whose forseeable time exceeds 1 hour and requires a surgical antibiotic prophylaxis by vancomycin or clindamycin + gentamicin exclusion criteria: * morbid obesity (bmi \> 35 kg/m2) * mild to severe renal impairment (clearance creatinine \< 60 ml/min) * vancomycin, clindamycin or gentamicin hypersensitivity * pregnancy
clinical performance of different resin cements

Conditions: Restoration of Posterior Teeth

Summary: the clinical performance of different resin cements in adhesion of hybrid ceramic inlay and onlay restorations produced with cad/cam will be evaluated and compared. after obtaining a signed informed consent form from all the patients, all restorations will be placed by a single clinician. all hyrid ceramic restorations (cerasmart, gc, tokyo, japan) will be produced using the same cad/cam cerec omnicam (sirona dental, bensheim, germany) system. 70 restorations will be divided into 2 groups: a self adhesive resin cement (relyx u200 automix, 3m espe, seefeld, germany), and an adhesive cement (g-cem linkforce, gc, tokyo, japan) which is applied after surface treatment (etch\&rinse). all restorative procedures will be conducted according to manufacturers' instructions. restorations will be scored using modified united states public health service (usphs) criteria after baseline, 6,12, 18, 24, 36 and 48 months. descriptive statistics will be performed using friedman test and chi-square test.


Eligibility criteria:
inclusion criteria: * healthy individuals with or without systemic disease * patiens older than 18 years old * good oral health * patients who at least have1 large and deep carious lesion or broken restoration in a vital tooth * patients who agreed to participate in the study after being informed about this study exclusion criteria: * patient with periodontal disease * patients with partial dentures * patients with bruxism * patients with malooclusion * non vital or endodontically treated teeth * preparetions under the cemento-enamel junction

Keywords: cad/cam inlay onlay hybrid ceramic adhesive resin cement
parent specific depression education and motivation

Conditions: Depressive Symptoms

Summary: this project is an investigator-initiated, randomized-controlled trial of the effectiveness of written and verbal parent-specific depression education and motivational advice in increasing participants self-disclosed intention to seek follow-up care for possible depression symptoms. the control condition is written and verbal general depression education and advice. hypothesis: the office-based experimental intervention of written and verbal parent-specific depression and emotional health education and motivational advice increases intention to seek follow-up services for emotional health or depression, when compared to written and verbal general depression education and advice.

maternal depression is a common problem, debilitating for mothers and affecting parenting practices with negative effects on the behavior, development, and physical health of children. the value of identifying and treating maternal depression for child development and well-being is well documented. unfortunately, there are multiple barriers to the recognition and treatment of maternal depression. this is particularly problematic in younger women, as they are less often seen for health care. the overall objective of this project is to test whether the uptake of follow-up recommendations for potential depression by mothers identified by screening in clinical settings is improved by parent-specific targetting of depression education and motivational advice.

Eligibility criteria:
inclusion criteria: * parent of a child between the ages of 2 days and 12 years who is a patient of the uc davis pediatric clinic. * primary, female caregiver * feeling down, depressed, or hopeless or little interest or pleasure in doing things. * not currently receiving care from a mental health practitioner. * comfortable speaking english without an interpreter. exclusion criteria: * parent of a child younger than 2 days or older than 12 years. * dad, foster parent, or other short term guardian. * currently in treatment with a mental health practitioner. * limited english proficiency

Keywords: depression treatment motivation to seek follow up
a long term study of the safety of tanezumab when administered by subcutaneous injections

Conditions: Osteoarthritis, Knee; Osteoarthritis, Hip

Summary: this study will investigate the safety of three fixed dose levels of tanezumab (2.5 mg, 5 mg, and 10 mg) administered at an 8-week interval by subcutaneous injection multiple (7) times during the study treatment period.

safety study of tanezumab in relief of osteoarthritis pain this study was terminated on 6 december 2010 following a us fda clinical hold for tanezumab osteoarthritis clinical studies which halted dosing and enrollment of patients on 23 june 2010 for potential safety issues.

Eligibility criteria:
inclusion criteria: * osteoarthritis of the knee or hip based on american college of rheumatology criteria with a radiographic (x ray) confirmation (a kellgren lawrence x-ray grade of ≥2); exclusion criteria: * body mass index (bmi) of \>39 kg/m2; * pregnancy or intent to become pregnant * planned surgical procedure during the duration of the study * history of clinically significant cardiovascular, central nervous system or psychiatric disease * previous exposure to exogenous ngf or to an anti ngf antibody; * use of biologics other than study medication, live or live-attenuated intranasal vaccines (eg, flumist), are allowable exceptions

Keywords: double-blind safety
premature infants in need of transfusion (pint)

Conditions: Anemia of Prematurity

Summary: hypothesis: that a high hemoglobin threshold for transfusion in extremely low birth weight (elbw) infants is associated with a lower rate of survival without severe morbidity (defined as one or more of retinopathy of prematurity, bronchopulmonary dysplasia, or periventricular leukomalacia/ventriculomegaly). primary objective: to determine whether either a liberal or more restrictive threshold of hemoglobin level for red cell transfusion in elbw infants is safer, by randomizing to either a high transfusion hemoglobin threshold or a low transfusion hemoglobin threshold. follow-up at a corrected age of 18 months represents a conventional age at which to first assess neurodevelopmental outcomes, and to predict long-term outcomes.


Eligibility criteria:
inclusion criteria: * birth weight \<1000g * postnatal age \<48 hours * no transfusion beyond first 6 hours of life * estimated gestational age of 30 completed weeks or less exclusion criteria: * infant considered non-viable by attending physician * infant has cyanotic congenital heart disease * infant's parents known to be opposed to blood transfusion * either parent has hemoglobinopathies or congenital anemias * infant has hemolytic disease * infant has severe acute hemorrhage, severe shock, severe sepsis with coagulopathy or requires peri-operative transfusion * prior treatment with or intention to treat with erythropoietin

Keywords: elbw premature infants neonatal transfusion bronchopulmonary dysplasia periventricular leukomalacia ventriculomegaly retinopathy of prematurity
a study to compare efficacy, safety, and immunogenicity of gme751 and eu-authorized keytruda in adult participants with untreated metastatic non-squamous non-small cell lung cancer (nsclc)

Conditions: Metastatic NSCLC

Summary: the purpose of this study is to investigate the efficacy, safety, and immunogenicity of gme751 compared with keytruda® (pembrolizumab) in participants with untreated metastatic non-squamous nsclc (irrespective of pd-l1 status), without sensitizing egfr or alk mutations.

eligible participants will be randomized in a 1:1 ratio to receive either gme751, or european union (eu)-authorized pembrolizumab (keytruda-eu) in combination with chemotherapy. the maximum study duration for a participant will be approximately 56 weeks including screening. treatment duration is 52 weeks (17 treatment cycles of study treatment gme751 or keytruda-eu in combination with chemotherapy, each cycle with a duration of 3 weeks). participants will discontinue study participation in case of disease progression, unacceptable toxicity or other reasons. participants who are benefiting from treatment with pembrolizumab without signs of progression or unacceptable toxicity will be eligible for continued pembrolizumab treatment via most suitable option based on the respective country regulations.

Eligibility criteria:
inclusion criteria: * at least 18 years of age * untreated metastatic nsclc * absence of tumor activating egfr mutations and absence of alk gene rearrangements * measurable disease according to recist 1.1 * adequate organ function * eastern cooperative oncology group (ecog) performance status score of 0 or 1 exclusion criteria: * squamous cell or mixed histology in nsclc * known history of hypersensitivity (grade ≥3) to pembrolizumab, chemotherapy or their excipients * active autoimmune disease that has required chronic systemic treatment in the past 2 years. * received live vaccine ≤30 days before the first study treatment * prior treatment with pembrolizumab or any other anti-pd-1, or anti-pd-l1 or anti-pd-l2, or anti-ctla-4 agent or any antibody targeting other immune-regulatory receptors or mechanisms for lung cancer. other protocol-defined inclusion/exclusion criteria apply.