Kornimate/medical-research-clean huggingface dataset:
the relationship between salt restriction and taste sensitivity in patients with chronic kidney disease

Conditions: Renal Insufficiency, Chronic; Chronic Kidney Diseases

Summary: the compliance of salt restriction in patients with ckd may be associated with taste sensitivity.


Eligibility criteria:
inclusion criteria: * stage 3-5 ckd patients * clinical stable exclusion criteria: * renal replacement therapy * cancer * systemic infection * alzheimer's disease * acute cardiovascular events, active hepatitis * all other study-obstructive conditions

Keywords: taste threshold salt restriction
myocardial oedema in st segment elevation myocardial infarction myocardial

Conditions: ST Segment Elevation Myocardial Infarction; Myocardial Oedema

Summary: cardiac magnetic resonance imaging (cmr) is a non invasive technique used to obtain functional and anatomical information on the heart. several cmr parameters measured after primary percutaneous coronary intervention (ppci) have been shown to have prognostic value and are increasingly being used as surrogate endpoints in clinical trials. myocardial oedema is a prognostic indicator following myocardial infarction1. myocardial salvage is calculated as the myocardial oedema minus infarct size; this again is a prognostic indicator following stemi. however, myocardial oedema imaging is controversial. there are multiple sequences available, with no standardisation of sequences used to assess this surrogate endpoint. the investigators propose to conduct a study to measure the myocardial oedema by all available techniques to determine the agreement between these methods.


Eligibility criteria:
inclusion criteria: * stemi * providing written informed consent exclusion criteria: * contraindication to cmr, * atrial fibrillation, * claustrophobia, * egfr \< 30

Keywords: stemi myocardial edema cardiovascular magnetic resonance
elastography ultrasound in localized scleroderma (morphea) study

Conditions: Scleroderma

Summary: localized scleroderma (ls) is a skin disease that can cause complications such as disfigurement and limitation of mobility. treatment for ls should be initiated early in the disease, as late-stage scleroderma does not respond well to treatment. objective tools for diagnosis and follow-up of treatment for ls are not available clinically and are urgently needed. a new non-invasive ultrasound technique called "elastography" measures stiffness of tissues and holds potential for providing objective measures for follow-up of treatment of ls in children and adolescents. the team plans to conduct a multicenter study in north america to determine whether elastography ultrasound can show changes in skin stiffness for a period of 9 to 12 months after initiation of treatment for ls. this novel technology may add information to the existing imperfect clinical tools, thus improving the way therapy is offered to patients with ls.


Eligibility criteria:
inclusion criteria: * boys and girls 0-18 years of age at the time of disease onset with a new or existing diagnosis of localized scleroderma (ls) confirmed by a pediatric rheumatologist or dermatologist. * presents with one active or inactive lesion, using the contralateral site for comparison at each visit, as long as the same lesion is evaluated at each time point. or presents with more than one lesion as far as both lesions are active or inactive. * able to cooperate with clinical and us evaluation, and the parent or guardian is able to fill out interim patient history form. exclusion criteria: * patients with other co-morbidities (e.g. systemic sclerosis, juvenile idiopathic arthritis, other systemic diseases). * patients who present with one active and one inactive lesion. * patients with lesions located in the face or head.

Keywords: elastography ultrasound scleroderma quality of life pediatric
effects of a western-type diet on colorectal inflammation

Conditions: Colorectal Inflammation

Summary: this study will look at the inflammatory (changes usually associated with infection/injury to the body) and bowel permeability (bowel's ability to allow contents to enter the body) effects of a western-style diet (high fat and low in calcium) and a prudent-style diet (low fat and high in calcium) on the colon (large bowel). this study may provide information to prevent colorectal cancer in a high-risk population

hypothesis: compared to a prudent-style diet, does a western-style diet increase colorectal inflammation thereby increasing gut permeability and causing increased endotoxins and markers of systemic inflammation. this is a single blind crossover study. subjects will be randomized to begin on either a wd or a pd for 30 + 3 days. once that dietary intervention is complete, subjects will have a four (4) week wash-out period and then will be placed on the other dietary intervention for 30 + 3 days. the following study measures are performed during both the dietary intervention study periods. all the baseline tests will be repeated at the end of each dietary intervention period.

Eligibility criteria:
inclusion criteria: * healthy male or post-menopausal ( 2 years after menopause or stopping hrt)healthy female subjects * age between 50 and 72 years * at increased risk for colorectal cancer (this includes those have had a colorectal adenoma excised, or have a first or second degree relative with colorectal neoplasia). exclusion criteria: * personal history of cancer other than non-melanoma skin cancer within the past 10 years * history of hereditary non-polyposis colon cancer * intestinal malabsorption, inflammatory bowel disease * prior gastrointestinal surgery other than appendectomy or surgery of the esophagus * any excess bleeding or coagulation disorders * subjects taking anti-coagulants, sterol-binding resins, nsaids other than aspirin, \< 600mg per day, other study medications, or other multiple medications that might, in the view of the study physicians, alter colonic function or inflammation * total cholesterol greater than 240mg/dl, triglycerides \> 600mg, ldl-c \> 175 * subjects with a history of coronary artery disease * hiv positive subjects * subjects taking antibiotics, anti-diabetes, hormone replacement therapy, oral, transplanted or injected contraceptives (thyroid hormone therapy is permitted as long as the subject is euthyroid) * currently participating in other clinical studies or completed participation in other clinical studies within the last 30 days
"the impact of immunonutrition on gut microbiota-related aspects in colorectal cancer and gastric cancer patients"

Conditions: Gastric Cancer; Colorectal Cancer

Summary: enteral immunomodulating nutrition modifies the gastrointestinal microbiota as well as improves the intestinal barrier integrity in patients with gastric and colorectal cancer in the perioperative period. as a consequence, it contributes to the reduction of the incidence of postoperative complications and diarrhea, which is a side effect of anti-cancer treatment often used preoperatively in this group of cancers.


Eligibility criteria:
inclusion criteria: * age \>18 y.o. * patients with gastric or colorectal cancer * patients treated in department of surgical oncology, medical university of gdańsk * patients' agreement to take part in this study exclusion criteria: * age \<18 y.o. * other types of cancer than gastric/colorectal cancer * the presence of inflammatory bowel disease * pregnancy

Keywords: gut microbiota gut barrier integrity enteral immunonutrition gastric cancer colorectal cancer
neoadjuvant chemotherapy for locally advanced squamous cell cancer of the head and neck (scchn)

Conditions: Hypopharyngeal Cancer

Summary: the investigators will examine whether 2-cycles of dfp chemotherapy before definitive concurrent chemoradiation therapy (ccrt) can improve progression-free survival in locally advanced (stage iii \& ivm0) hypopharyngeal and base of tongue carcinoma compared to definitive ccrt alone.


Eligibility criteria:
inclusion criteria: * histologically/cytologically proven stage iii/ivm0 hypopharyngeal or base of tongue cancer * one or more evaluable or measurable lesion * no prior chemotherapy, radiation, or surgery * ecog 0-2 exclusion criteria: * distant metastasis * other malignancy

Keywords: neoadjuvant chemotherapy definitive chemoradiation therapy head and neck cancer base of tongue locally advanced
withings ecg-app study

Conditions: Atrial Fibrillation

Summary: the aim of the study is to evaluate the performance of withings hwa10 with embedded withings ecg-app in the automatic detection of atrial fibrillation


Eligibility criteria:
inclusion criteria: * male or female who are 22 years of age or older * subject able to read, understand, and provide written informed consent * subject willing and able to participate in the study procedures as described in the consent form * subject able to communicate effectively with and willing to follow instructions from the study staff * have a wrist circumference between 140 mm and 210 mm (measured at "band center" on the preferred wrist, 1cm from the bone. this location is determined by asking the volunteer to put on a normal wrist-watch and marking the skin with a pen/marker to outline the edges of the band.) exclusion criteria: * vulnerable subject with regard to regulations in force * subject who is deprived of liberty by judicial, medical or administrative decision, * underage subject, * legally protected subject, or subject who is unable, linguistic or psychic incapacity, to sign the written informed consent form, * subject within several of the above categories, * subject who refused to participate in the study, * subject mentally impaired resulting in limited ability to cooperate * subject in physical incapacity to wear a watch on one wrist and place the other hand on top of the watch * subject with electrical stimulation by pacemaker * patient with pathologic disorder that may affect motricity resulting in significant tremor that prevents subject from being able to hold still (e.g parkinson disease) * acute myocardial infarction (mi) within 90 days of screening or other cardiovascular disease that, in the opinion of the investigator, may increase the risk to the subject or renders data uninterpretable (e.g., recent or ongoing unstable angina, decompensated heart failure, active myocarditis or pericarditis) * acute pulmonary embolism or pulmonary infarction, within 90 days of screening * stroke or transient ischemic attack within 90 days of screening * active life-threatening rhythms as determined by the investigator (ventricular tachycardia, ventricular fibrillation, 3 rd -degree heart block). * history of abnormal life-threatening rhythms (ventricular tachycardia, ventricular fibrillation, 3 rd -degree heart block) * symptomatic (or active) allergic skin reactions such as eczema, rosacea, impetigo, dermatomyositis or allergic contact dermatitis on both wrists or over electrode attachment sites * known sensitivity to medical adhesives, isopropyl alcohol, watch bands, or electrocardiogram (ecg) electrodes including known allergy or sensitivity to fluoroelastomer bands primarily used in wrist worn fitness devices

Keywords: mhealth atrial fibrillation
national survey on asthma

Conditions: Asthma

Summary: to evaluate the concordance of the most frequently used words by the patients and the physicians to express asthma symptoms, according to the patient's level of asthma control.


Eligibility criteria:
inclusion criteria: * a diagnosis of persistent asthma treated with an inhaled corticosteroid based maintenance treatment for more than 3 months * given his/her consent to participate to the study and who is able to answer the questionnaire in french by him/her-self. exclusion criteria: * patient with a cardiac disease (congestive heart failure, coronary artery disease) * patient with a respiratory disease other than asthma (copd, sleep apnea syndrome).

Keywords: asthma symptoms words used by patients and physicians express asthma symptoms
toothbrush wear and its effect on subgingival inflammation using two different brushing techniques

Conditions: Gingival Inflammation

Summary: toothbrush plaque removal, along with interproximal flossing, helps to maintain the oral cavity free from periodontal diseases and dental caries. although techniques such as the bass technique (bt), the modified bass technique (mbt) and the modified stillman technique (mst) are taught to dental students, dental hygiene students, and dental assistants, there is little evidence to discern which technique is more effective in reducing or preventing gingival inflammation. at tufts university school of dental medicine (tusdm), a modification of the bass intrasulcular technique is advocated to many students. we call this modification of the bass technique a stationary bristle technique (sbt), which is an intrasulcular technique that maintains the toothbrush bristle ends essentially stationary on the tooth cervically and in the gingival crevice. in this study, half of the participants were taught the stationary bristle technique group, while the other half were not be provided with instructions, but asked to brush as normal (non-interventional group) throughout the duration of the study.

this is a double-armed, randomized clinical trial. the primary aim of this study is to compare whether a stationary brushing technique (sbt) is more effective in the reduction of gingival inflammation than permitting people to brush the way they normally do without instruction (non-stationary brushing technique). gingival inflammation is evidenced by the percentage (%) sites with bleeding on probing (bop). the primary time-point will be at 4 weeks. the amount of toothbrush bristle deformation at 4 weeks, 12, and 16 weeks of brushing with a sbt and with a nsbt will also be evaluated. 3. the secondary evaluation of bop will be at the 12 and 16 week time-point.

Eligibility criteria:
inclusion criteria: * subjects must be at least 18 years of age * subjects must have at least 20 teeth * subjects must have had a professional dental prophylaxis done in the 3 months prior to the beginning of the study * subjects exhibiting 10% or greater bop at the baseline examination exclusion criteria: * subjects wearing fixed orthodontic appliances (including lingual retainers or invisalign®) * subjects who smoke (=more than 0 cigarettes a day) * subjects who received antibiotic treatment during the month prior to the beginning of the study * subjects who have cervical probing depth (pd) greater than 3mm * subjects diagnosed with periodontal disease at any site as defined bleeding on probing with cervical probing depths greater than 3 mm and loss of cervical attachment. * subjects who are currently pregnant (self-report).
study on the effects of periodontal treatment along with the use of antibiotics over high sensitive c-reactive protein. randomized controlled clinical trial.

Conditions: Chronic Periodontitis

Summary: human periodontitis is a group of highly prevalent oral inflammatory diseases and infections with relatively easy treatment and preventive features. the present study is aimed to determine if treating human individuals with chronic periodontitis, along with the use of antibiotics, reduces cardiovascular risk marker (hspcr) and also intends to identify if severity of periodontitis could be associated with a raise of systemic inflammatory biomarkers on baseline.


Eligibility criteria:
inclusion criteria: * must be of legal age (≥ 18 years old) * voluntary participation and signed information consent * confirmed systemically healthy individual * at least 15 teeth present in mouth exclusion criteria * pregnant women * smokers * antibiotic consumption 6 months before inclusion * hiv positive or aids * allergic reactions to macrolides and specifically to azithromycin * periodontal treatment 6 months before inclusion
treatment decisions for multi-vessel cad

Conditions: Coronary Artery Disease

Summary: this study is a multi-center randomized trial to evaluate the multi-vessel coronary artery disease option grid patient decision aid compared to usual care in patient reported decisional conflict, knowledge, and shared decision making.

multi-vessel coronary artery disease can be treated through percutaneous coronary intervention, coronary artery bypass grafting, or medical therapy. treatments have risk benefit tradeoffs, making patient preference integral to the treatment decision. the multi-vessel coronary artery disease option grid patient decision aid was developed to improve the decision making process for patients and clinicians. objectives: 1. evaluate the multi-vessel coronary artery disease option grid impact on patient treatment decisional conflict, knowledge, and shared decision making. the randomized controlled trial will compare validated and standardized measures of patient decisional conflict, shared decision making, and condition specific treatment knowledge between option grid and usual care patients. the investigators hypothesize option grid patients will have improvements in patient decisional conflict, shared decision making, and knowledge compared to usual care patients. baseline feasibility enrollment at each site prior to randomization will be used to identify current treatment patterns, and prepare intervention delivery and fidelity. registry data will be used to identify patient treatment received and compared between option grid and usual care arms. 2. examine the physician and patient process of and factors influencing multi-vessel coronary artery disease option grid use. semi-structured interviews and process evaluations will be used to describe option grid use and experience and identify factors that are associated with beneficial option grid use.

Eligibility criteria:
inclusion criteria: * stable multi-vessel coronary artery disease diagnosed by coronary angiography defined as left main disease (\>50% stenosis) or multi-vessel coronary artery disease (\>70% stenosis in two or more coronary arteries) * at relative equipoise for at least two potential treatment options, in which the treating cardiologist or surgeon has determined the treatments are anatomically feasible and safe. exclusion criteria: * prior coronary artery bypass grafting * unable to read or write english * not cognitively able to participate in the option grid as determined by clinician

Keywords: patient decision aid multi-vessel coronary artery disease
use of procalcitonin level for guidance of the treatment of suspected community acquired pneumonia

Conditions: Pneumonia; Radiographic Lung Infiltrates

Summary: the purpose of the study is to learn if a blood test is helpful to the doctors in deciding whether you need antibiotic therapy for possible pneumonia. the blood test is called a procalcitonin level and sometimes the test reflects infection with certain bacteria (germs). when the doctors learn the results of these blood tests, they may be able to stop some of the antibiotic medications that they may have given to the patients. the study is designed, so that on a randomized basis (50/50 chance) the results from measuring procalcitonin will be given to the patients' doctor. when the doctor receives these results, he/she may use this information, along with other information, to decide whether to continue antibiotic therapy.

to evaluate the usefulness of serum procalcitonin level measured to guide the antibiotic treatment of patients with radiographic lung infiltrates.the subjects involved in the study will be divided in two arms ,study arm where the caregivers will know the result of procalcitonin level and they can change /withheld the antibiotic for the subjects.in other arm only investigators will know the procalcitonin level. we expect to enroll 100 patients.

Eligibility criteria:
inclusion criteria: * adults * new radiographic findings consistent with the presence of infiltrates * antibiotic therapy exclusion criteria: * critically ill patients on admission

Keywords: pneumonia lung infiltrates antibiotic discontinuation de-escalation therapy
pwp1's expression in gastric cancer.

Conditions: Diagnosis; Gastric Cancer

Summary: background：gastric cancer is a globally important disease and the fifth most diagnosed malignant cancer in the world. because it is usually diagnosed at an advanced stage, gastric cancer has a high mortality rate, making it the third most common cause of cancer-related death. hot spots of gastric cancer incidence and mortality exist in east asia, eastern europe and south america. it is still an urgent problem to find new diagnostic and prognostic markers and better understand the molecular mechanism of gastric cancer. although radical resection and systemic chemotherapy have shown great improvement, the prognosis of gastric cancer (gc) patients is still depressing due to malignant proliferation and metastasis. therefore, it is urgent to clarify the potential molecular mechanism of gastric cancer progression, which will contribute to the development of targeted therapy. effective induction of tumor cell apoptosis is the most important feature of a new chemical agent for cancer treatment. there is increasing evidence that the cell cycle can act in concert with apoptosis to cause cell death under certain cellular stress conditions. a comprehensive understanding of the relationship between apoptosis and cell cycle is essential for developing effective cancer therapies. pwp1 is also known as endonuclein, which contains five wd40 repeated domains and belongs to the wd40-repeated superfamily. it is highly expressed in human pancreatic adenocarcinoma, where it functions as a cell-cycle regulator. however, the normal function of pwp1 is largely unknown. previous research data show that pwp1 plays a key role in regulating biological functions such as rna processing, signal transduction, gene expression, vesicle transport, cytoskeleton assembly and cell cycle progression. whether the high expression of pwp1 is ubiquitous in tumors, the relationship between the high expression and clinicopathological factors of tumors, and the mechanism of pwp1 in tumors are still unclear. further exploration of the molecular mechanism of pwp1 in gc may provide new ideas and therapeutic targets for gc treatment in the future, and benefit clinical patients.


Eligibility criteria:
inclusion criteria: * diagnosed as gastric cancer * performing gastric cancer resection surgery * informed consent signed prior to surgery. exclusion criteria: * emergency surgery * preoperative and intraoperative detection of distant organ metastases or extensive * no standard chemotherapy for tumor-node-metastasis (tnm) staging ii or iii after surgery * incomplete case data.

Keywords: gastric cancer pwp1 ihc expression