Kornimate/medical-research-clean huggingface dataset:
an open-label controlled trial: effectiveness of balneotherapy in palmoplantar psoriasis and contact dermatitis.

Conditions: Psoriasis; Contact Dermatitis of Hand

Summary: patients who had an indication for phototherapy were included in this study. the treatment was used as a monotherapy protocol. the standard protocol for bathing puva involved applying 0.01% bath psoralen for 15 minutes, while the tap water group only received a tap water bath for 15 minutes and the salt water group received 3% salted (nacl) water before uva treatment. main tools to assess the efficacy is disease activity scores and quaity of life scores.

patients who met the criteria for phototherapy were included in this study. the treatment was used as a standalone protocol, with only moisturizer permitted. in order to participate, patients needed to have completed their last systemic treatment at least 2 months prior to the study, and their last topical treatment at least 4 weeks prior. patients were randomized using a computer program and assessed at the beginning of therapy, as well as after 12, 24, and 36 sessions. the standard bath-puva protocol involved applying 0.01% bath psoralen for 15 minutes, while the tap water group only received a tap water bath for 15 minutes, and the salt water group received a 3% salt water bath before uva exposure. all patients were educated about their condition and current treatment options. patients who participated in this study either had contraindications to other therapies or had experienced side effects previously. the initial uva dosage was 0.25 j/cm2, gradually increasing to a maximum of 5 j/cm2. during each evaluation, patients were assessed using various scales and tools to measure the severity of their psoriasis and their quality of life, as well as photographs. following a pilot study involving 5 patients in each group, a two score reduction in the disease activity score revealed that g power analysis determined that a total of at least 13 patients was needed to achieve 80% power. ethical approval was obtained before commencing the study.

Eligibility criteria:
inclusion criteria: * individuals aged between 18 and 65 * clinical diagnosis of palmoplantar psoriasis or contact dermatitis exclusion criteria: * individuals under 18 or over 65 * pregnancy or breastfeeding * history of malignancy * diagnosis of photodermatosis * prescription or use of photoallergenic or phototoxic drugs

Keywords: bath puva uva psorolene phototherapy local uv a
the effect of a new antioxidant combination (asted) on moderate to severe thyroid eye disease

Conditions: Thyroid Eye Disease

Summary: asted (antioxidant supplements for ted) trial is an investigator-initiated, randomized, triple masked, clinical trial of a selected combination of vitamins and minerals versus placebo in patients with moderate to severe thyroid eye disease. the trial has a parallel-arm design.

primary aim: to investigate if asted or as compared with placebo could affect the course of ted either by enhancing improvement or preventing worsening in patients with moderate to severe ted thyroid eye disease (ted) based on: 1. total eye score (nospecs severity score) 1 total eye score is used to assess the severity of ted, which was calculated by multiplying each class of the nospecs system1 (except class 0) to its grade of severity (0-3), yielding a maximum total score of 63 and a minimum total score of 0 (the higher the number the worse the severity) the overall ophthalmic outcome is a composite score based on multiple items (soft tissue, retraction, proptosis, diplopia, and corneal involvement); the use of a composite score circumvents the problem arising from the presence of improvement in one item and simultaneous worsening in another item. the severity score in each of the classes 1, 2, 3, and 4 will also be separately compared to evaluate the effect of different treatments on each sign. 2. score of thyroid eye disease quality of life questionnaire (ted-qol) 2. secondary outcomes measures: to compare possible change in: 1. clinical activity score (cas score) 3 (7 items are scored in the beginning and 10 items are scored at 3 and 6 months) 2. serum thyroid auto-antibodies (anti-thyroid peroxidase (tpo), anti-thyroglobulin) at 0, 3 and 6 months. thyroid function test (free t4, t3, and tsh) will be measured in all 3 visits0 3. side effects

Eligibility criteria:
inclusion criteria: * moderate to severe ted of less than 18 months duration: * active state (clinical activity score of 3 and more). * no steroid and or any supplement treatment for the last 6 months. * euthyroidism * age 18-70 years. exclusion criteria: * sight-threatening ted * pregnancy * drug and/or alcohol abuse * severe concomitant illness * inability to comply with the study protocol * no informed consent * developing more severe ted (sight threatening ted) in the course of the trial. * contraindications of steroid treatment.

Keywords: graves' ophthalmopathy antioxidant activity severity
kn026 in patients with her2 expressing breast cancer and gastric cancer

Conditions: Breast Cancer; Gastric/Gastroesophageal Junction Cancer

Summary: this is an open-label, phase 1 dose-escalation study of kn026 in subjects with her2 positive advanced breast and gastric cancer. the standard "3 + 3" design was used for dose escalation. there are 3 proposed dose levels which are 10, 15, and 20 mg/kg, but dosing interval may be adjusted during the study (such as qw, or q2w, or q3w) based on emerging data from this trial and/or from phase 1 trial of kn026 in other country. dose escalation will continue until the maximum tolerated dose (mtd) is reached or if mtd is not found, dose escalation will continue until the mad of 20 mg / kg is reached.


Eligibility criteria:
inclusion criteria: * male or female subject \>= 18 years * histologically/cytologically confirmed, locally advanced unresectable or metastatic breast cancer or gastric cancer. * ecog score 0 or 1 * life expectancy \>3 months * according to the definition of recist1.1, the patient has at least one measurable lesion * adequate organ function prior to start treatment with kn026 * able to understand, voluntarily participate and willing to sign the icf * subjects (women of child-bearing potential and males with fertile female partner) must be willing to use viable contraception method. exclusion criteria: * accepted any other anti-tumor drug therapies within 4 weeks before fist dose * accepted radiotherapy within 4 weeks before enrollment * an anthracyclines antibiotic treatment was received exceeding 300 mg/m² within 90 days before first kn026 dosing, or other equivalent dose antharcyclines * subjects are eligible with clinically controlled and stable neurologic function \>= 4 weeks, which is no evidence of cns disease progression; subjects with spinal cord compression and cancerous meningitis are not eligible * pregnant or nursing females；or intend pregnancy within this study period or within 6 monthes after the end of this study * history of immunodeficiency, including hiv positive or other acquired, congenital immunodeficiency disease, or a history of organ transplantation * severe chronic and active infection, need to system antibiosis/antiviral treatment * cavity effusion (pleural effusion, ascites, pericardial effusion, etc.) are not well controlled, and need locally treatment or repeated drainage
a clinical study of klh-2109 in patients with endometriosis

Conditions: Endometriosis

Summary: to verify the non-inferiority of klh-2109 to leuprorelin acetate in a double-blind manner in terms of efficacy in endometriosis patients with pelvic pain.


Eligibility criteria:
inclusion criteria: premenopausal women aged 18 years or older (at the time of consent) with endometriosis who meet any of the following inclusion criteria.: * a diagnosis of endometriosis by laparotomy or laparoscopy within 5 years before the start of the screening period; * ovarian chocolate cyst confirmed by mri performed within 1 year before the start of the screening period or ultrasonography (transvaginal, transabdominal, or transrectal) carried out at the start of the screening period; or * any of induration of the pouch of douglas, limitation of uterine mobility, and pelvic tenderness based on the result of pelvic/rectal examination at the start of the screening period and a diagnosis of clinical endometriosis exclusion criteria: 1. patients with undiagnosed abnormal genital bleeding 2. patients with abnormal uterine bleeding or anovulatory bleeding judged to be severe by the principal investigator or subinvestigator 3. patients with concomitant chronic abdominal pain not attributable to endometriosis (such as irritable bowel syndrome \[ibs\] and interstitial cystitis) 4. patients with concomitant pelvic inflammatory disease or a history of pelvic inflammatory disease within 8 weeks before obtaining informed consent
effectiveness of mind-body interventions for frequent attendees suffering from medically unexplained symptoms (mus)

Conditions: Neurasthenia; Chronic Pain; Chronic Headache

Summary: the purpose of this study is to check the medical efficacy and economic benefits of multidisciplinary care in patients with unexplained medical complaints and consume medical services frequently.

background: somatic or "medically unexplained" symptoms and syndromes are common and are seen by physicians across almost every medical specialty. in many instances, these phenomena can cause a great deal of pain and frustration, restrict function and reduce patients' quality of life. despite their frequency and severity, medical personnel often experience a great deal of difficulty in coping with such complaints and patients may be shuttled from specialist to specialist, often with little or no symptomatic relief and at a great deal of expense to the medical system. many researchers now believe that these seemingly unrelated and "unexplained" conditions in fact share common psycho-physiological mechanisms, such as being catalyzed as a result of trauma or excessive stress, being mediated by the limbic system and affecting inhibitory sensory pathways. purpose of the study: testing the efficacy and cost-efficiency of a holistic multidisciplinary treatment methodology for medically unexplained symptoms (mus). stages of the study: the study wil lbe conducted via two arms: 1. a reterospective study of patients attending the functional neurology clinic a soroka umc between the years 2014-2018 in which patient records will be obtained via the regional offices of clalit health services and analyzed in order to learn the effects of mind-body therapies on health care utilization. 2. a prospective study of new patients arriving at the "functional neurology" clinic at soroka umc. members of the second arm will be asked if they would be willing to participate in the study by their neurologist. participants who have agreed to join the study will fill out self-report measures at the beginning of their treatment, at the end of treatment (3 months) and 6 months after the start of treatment and 12 months after the start of treatment. expected results 1. a decrease in expense rates and use of medical services 2. an increase in patient satisfaction 3. an increase in patient-reported health and quality of life

Eligibility criteria:
inclusion criteria: * men or women * age 18 or higher * treated at the functional neurology clinic at soroka umc exclusion criteria: * patients with chronic illness such as cancer, dialysis patients, or any other severe identified illness * patients who do not speak hebrew * bedridden patients * schizophrenia, dementia and other severe mental illness

Keywords: cost-effective unexplained medical symptoms frequent attenders
inflammatory and metabolic outcomes after obese woman performed high intensity interval training

Conditions: Obesity and Metabolic Syndrome

Summary: the main purpose of this study is to compare the effects of high intensity interval training and moderate intensity continuous training on inflammatory profile and metabolic markers, after 8 weeks of intervention trial in obese women.


Eligibility criteria:
inclusion criteria: * body mass index between (30-40 kg/m²) * age between 25 and 41 years * to be sedentary exclusion criteria: * type 1 or type 2 diabetes * hypertension * pregnancy, lactation * having undergone bariatric surgery * psychological disorders, epilepsy, sever neurological disorders * participation in other moderate, vigorous exercise or nutrition intervention * acute or chronic cardiovascular disease * malignant disease * kidney disease * lung disease * hyperthyroidism or hypothyroidism * smoking any type of cigarette * joint limitations * electronic implants (defibrillator, pacemaker)

Keywords: high intensity interval training inflammation obesity adipokines
intermittent multifunctional nutrition tube in cerebral palsy and dysphagia

Conditions: Cerebral Palsy

Summary: this was a randomized controlled study including 80 infants with cerebral palsy and dysphagia. the participants were evenly divided into the observation group (with intermittent oro-esophageal tube feeding, n=40) and the control group (with persistent nasogastric tube feeding , n=40). nutritional status and physical development, condition of dysphagia, and pneumonia before and after 3-month treatment were compared.

in china, for nutrition support in the infants under one year of age with cerebral palsy and dysphagia, persistent nasogastric tube feeding is the mainstream choice. however, the efficacy of persistent nasogastric tube feeding is not sufficiently satisfactory, necessitating the exploration for a more effective and safe nutrition support approach. therefore, this study reports the clinical effect of intermittent oro-esophageal tube feeding compared to persistent nasogastric tube feeding in the infants with cerebral palsy and dysphagia who received systemic therapy. method this was a randomized controlled study including 80 infants with cerebral palsy and dysphagia. the participants were evenly divided into the observation group (with intermittent oro-esophageal tube feeding, n=40) and the control group (with persistent nasogastric tube feeding, n=40). nutritional status and physical development, condition of dysphagia, and pneumonia before and after 3-month treatment were compared.

Eligibility criteria:
inclusion criteria: * meeting the diagnostic criteria of cerebral palsy formulated by the 13th national conference on pediatric cerebral palsy rehabilitation; * age\<1 year; * diagnosed as dysphagia confirmed by dysphagia disorder survey or pediatric esophagoscopy; * with a nasogastric tube inserted at admission; * enteral nutrition support is required and feasible. exclusion criteria: * with dysphagia caused by other diseases or factors; * with progressive neurological disease or degenerative neurological disease; * with severe heart disease, liver or kidney dysfunction, hematological disorders, or other acute and severe symptoms; * with abnormalities in the oral cavity, pharynx, esophagus, or other parts of the digestive tract; * with poor compliance.
rsa-study of cemented hip prostheses with five different articulations

Conditions: Arthritis

Summary: the purpose of this study is to compare wear and migration of the following hip prostheses: 1. charnley monoblock 22.2mm caput and ogee polyethylene acetabular component 2. spectron ef stem with reflection polyethylene cup and 28 mm cocr caput 3. spectron ef stem with xlpe cup and 28 mm cocr caput 4. spectron ef stem with reflection polyethylene cup and 28 mm oxinium caput 5. spectron ef stem with xlpe cup and 28 mm oxinium caput

detailed description in: wear and migration of highly cross-linked and conventional cemented polyethylene cups with cobalt chrome or oxinium femoral heads: a randomized radiostereometric study of 150 patients. kadar t, hallan g, aamodt a, indrekvam k, badawy m, skredderstuen a, havelin li, stokke t, haugan k, espehaug b, furnes o. j orthop res. 2011 aug;29(8):1222-9. doi: 10.1002/jor.21389

Eligibility criteria:
inclusion criteria: * arthritis * dysplasia exclusion criteria: * obesitas * charcots * paget * malignancy

Keywords: rsa
image-guided navigation during robotic sentinel node removal

Conditions: Prostate Cancer

Summary: image-guided navigation based on pre-operative imaging can give the surgeon more insight into the location of the sentinel nodes in relation to other anatomical structures. the purpose of the study is to investigate the feasibility of image-guided navigation during robot-assisted surgery to treat cancer in the pelvic area.ultimately, the application of navigation during robot-assisted sentinel node dissection could potentially improve the outcome of surgery for the patient.

image-guided navigation surgery allows for full utilization of pre-operative imaging during surgery, and has the potential of reducing both irradical resections and morbidity. it has successfully been applied in the avl for open abdominal surgery, however more and more surgeries are being performed less invasive using robot surgery. rapid extension of robot-assisted surgery has increased the need for robot-compliant image-guided techniques. unfortunately, tactile feedback is lacking in these robotic surgeries, which increases the additional value of image-guided navigation. in this study, patients will undergo an abdominal sentinel node dissection in order to evaluate the actual technical benefit of robotic navigation. this is the first feasibility study towards clinical implementation of the navigation setup into robot-assisted image-guided navigation surgery. the results of this study will be the base for new studies, evaluating the clinical benefit of image-guided navigation for robot surgeries.

Eligibility criteria:
inclusion criteria: * scheduled for abdominal robotic sentinel node resection * ≥ 18 years old * provided written 'informed consent' * sentinel nodes should be fixed relative to retroperitoneal structures or major vessels. exclusion criteria: * metal hip implants / implants in the pelvic area * pacemaker, defibrillator
applied forces during neonatal intubation at different heights of the resuscitation table

Conditions: Neonatal Disease; Intubation

Summary: the study aims to compare the applied forces during intubation of a newborn manikin with direct and video laryngoscope at different heights of the resuscitation table. furthermore, the success at the first attempt, the intubation time and participants' opinion on the procedures were investigated. this is an unblinded, randomized, controlled, crossover trial on the applied forces during intubation of a newborn manikin with direct and video laryngoscope at different heights of the resuscitation table.

background: endotracheal intubation is an important life-saving procedure for critically ill neonates. some procedure-related aspects may affect the quality of the intubation. optimizing the relative height between patient and operator may improve intubation procedures. objectives: to compare the applied forces during intubation of a newborn manikin with direct and video laryngoscope at different heights of the resuscitation table. furthermore, the success at the first attempt, the intubation time, and participants' opinions on the procedures were investigated. methods: this is an unblinded, randomized, controlled, crossover trial on the applied forces during intubation of a newborn manikin with direct and video laryngoscope at different heights of the resuscitation table. participants will be level iii nicu/picu consultants, and pediatric residents. randomization will be performed using a computer-generated random assignment list. the primary outcome measure will be the forces applied on the neonatal manikin during the intubation. the secondary outcome measures will be the success of the first attempt, the total time of intubation, and participants' opinions about the procedure.

Eligibility criteria:
inclusion criteria: * level iii nicu and picu consultants, and pediatric residents exclusion criteria: * refusal to participate

Keywords: neonate intubation direct laryngoscopy video laryngoscopy forces simulation
to evaluate the efficacy of z-338 in subjects with functional dyspepsia

Conditions: Functional Dyspepsia

Summary: to evaluate the efficacy of z-338 in subjects with functional dyspepsia, focusing on the assessment of subjective symptoms in order to further determine the optimal dosage and efficacy parameters for phaseiii clinical trials.


Eligibility criteria:
inclusion criteria: * postprandial fullness, upper abdominal bloating and/or early satiety should be at least moderate for 2 days or more at the 7 days at visit 1 * upper abdominal pain, upper abdominal discomfort, postprandial fullness, upper abdominal bloating, early satiety, nausea, vomit and belching should be at least moderate for at least 2 symptoms for 2 days or more at the 7 days at visit 1 exclusion criteria: * subjects taht heartburn should be the most bothersome symptom * subjects presenting with primary complaints relieved by stool movements (ibs) * subjects with diabetes by treatment * subjects taht heartburn should be more than moderate
investigation of pelvic floor muscle strength in low back pain

Conditions: Low Back Pain, Mechanical; Pelvic Floor Muscle Weakness; Non-specific Low Back Pain; Disability Physical; Pain

Summary: to evaluate the effect of pelvic floor muscle strength on women with non-specific low back pain


Eligibility criteria:
inclusion criteria: * being a woman * 18-50 years old * bmi≤30 for the nslbp group: * diagnosed with non-specific low back pain by a specialist physician, * have low back pain for at least 3 months, * have no pain radiating to the leg, * have low back pain 3 or higher on the visual analog scale (vas, 0-10 scale) exclusion criteria: * have a somatic or psychiatric disorder, * have signs and symptoms associated with other conditions such as nerve root compression (at least 2 of these symptoms: weakness, reflex changes or loss of sensation associated with the same spinal nerve), * have had previous spinal surgery or are scheduled for surgery, * pregnant * have neurological and pelvic inflammatory diseases

Keywords: non-specific low back pain perinometer pelvic floor muscle disability pain
atraumatic care practice from the child and parent perspective

Conditions: Nurse's Role

Summary: it is important for pediatric nurses to apply atraumatic care while providing care to children and their families. pediatric nurses should use methods appropriate for the child's age and developmental period within the scope of atraumatic care.

the use of atraumatic care approaches such as supporting the active participation of the family in the care of the child, using therapeutic communication techniques with parents and children during procedures, providing emotional support, reducing pain during painful procedures, using techniques to distract the child's attention during medical procedures, informing parents about the procedures to be performed on their children, and supporting parents and teaching techniques to cope with stress is recommended to be used by the nurses.

Eligibility criteria:
inclusion criteria: * being able to speak turkish * being between 5-10 years of age * having no visual, intellectual or neurological disabilities * having the phlebotomy procedure carried out with a single attempt * not having a disease that causes chronic pain * being accompanied by either mother or father during the procedure * not taking painkillers or sedating drugs before the phlebotomy procedure exclusion criteria: * being younger than 5 years or older than 10 years * having visual, audio, or speech impairments * having a disease that causes chronic pain * with a history of sedative and analgesic use within 24 h prior to admission * filling out the data collection forms incompletely

Keywords: child fear pain phlebotomy distraction methods atraumatic care