Kornimate/medical-research-clean huggingface dataset:
long-term effects of combined balance and brisk walking in parkinson's disease

Conditions: Parkinson Disease

Summary: parkinson's disease (pd) is a progressive neurodegenerative disease characterized with both clinical motor and non-motor features, as well as decrease in balance performance and walking endurance. the non-motor symptoms such as depression, anxiety, sleep disturbance and fatigue wound impose negative impacts on the quality of life of the individuals with pd. aerobic endurance training can improve physical capacity and reduce those non-motor symptoms such as mood and sleep disorders. based on the results of our recent pilot study, brisk walking is a safe and moderate-level aerobic walking exercise for improving walking capacity in the pd population up to 6 week after treatment ended. community-based balance training could also enhance balance performance and dual-task gait performance up to 12-month follow-up for people with pd. the primary purpose of this proposed study is to investigate the short- and long-term effects of a 6-month balance and brisk walking programme in alleviating non-motor and motor symptoms in people with pd. the secondary objective is to examine the short- and long-term effects of a 6-month balance and brisk walking program on enhancing walking capacity, balance performance, and quality of life.


Eligibility criteria:
inclusion criteria: * parkinson disease diagnosed by neurologist with hoehn \& yahr stage 2 or 3 * having a 30-meter walking ability exclusion criteria: * significant neurological condition (other than parkinson's disease) * musculoskeletal conditions affecting gait, balance or functions * had received deep brain stimulation surgery * cognitive impairment with montreal cognitive assessment score \<24 * present with on-off motor fluctuations.

Keywords: rehabilitation aerobic exercise postural balance
effects of group-based and digitally delivered cbt-i in youth

Conditions: Insomnia

Summary: adolescence is a critical transitional stage characterised by a cascade of developmental changes in biological, cognitive, and psychological functioning. sleep problems, particularly insomnia, are prevalent in adolescents, with a prevalence rate as high as 36%. insomnia symptoms, presented as the problems initiating sleep or maintaining sleep, have often been reported in association with adverse outcomes in adolescents, including an increased risk of developing depression, anxiety, interpersonal problems, somatic health problems, self-harm and suicidal ideation. this study tests the efficacy of cognitive behavioural therapy for insomnia (cbt-i) in reducing insomnia severity in youth with insomnia.


Eligibility criteria:
inclusion criteria: * (1) chinese aged 12-20 years old (an age range that was similarly adopted in the previous studies to cover a wider developmental span in adolescence); * (2) written informed consent of participation into the study is given by the participant and his/her parent or guardian (for those aged under 18); * (3) willing to comply with the study protocol; * (4) meeting the diagnostic and statistical manual of mental disorders (dsm-5) diagnostic criteria of insomnia disorder and with a score on insomnia severity index (isi) - 9 (suggested cut-off for adolescents) exclusion criteria: * (1) a current diagnosis of substance abuse or dependence; a current or past history of manic or hypomanic episode, schizophrenia spectrum disorders, neurodevelopmental disorders, organic mental disorders, or intellectual disabilities; * (2) having a prominent medical condition known to interfere with sleep continuity and quality (e.g. eczema, gastro-oesophageal reflux disease); * (3) having a clinically diagnosed sleep disorder that may potentially contribute to a disruption in sleep continuity and quality, such as narcolepsy, sleep-disordered breathing, and restless leg syndrome, as ascertained by the structured interview for sleep patterns and disorders (disp), a validated structured diagnostic interview to assess major sleep disorders according to the international classification of sleep disorder (icsd) criteria; * (4) concurrent, regular use of medications(s) known to affect sleep continuity and quality including both western medications (e.g. hypnotics, steroids) and over-the-counter (otc) medications (e.g. melatonin, traditional chinese medicine, tcm); * (5) having been enrolled in any other clinical trial investigational products within one month at the entry of the study; * (6) in the opinion of the research clinician, having a clinically significant suicidality (presence of suicidal ideation with a plan or an attempt) as assessed by mini-international neuropsychiatric interview (mini); * (7) currently receiving any structured psychotherapy; * (8) with hearing or speech deficit; (9) night shift worker.

Keywords: youth sleep insomnia cbt-i
value of intense phenotyping in heart failure with preserved ejection fraction

Conditions: Heart Failure, Diastolic

Summary: heart failure (hf) with a left ventricular ejection fraction (lvef) \>0.40 is a large medical problem, for which no drug or device has a recommendation in current hf guidelines. the prevalence of mortality and hf hospitalizations in hf with lvef \>0.40 is high, but the identification of predictors for increased risk of mortality and hf hospitalizations in this patient category remains difficult. the hypothesis of this study is that the risk of all-cause mortality and hf hospitalizations can be measured by clinical factors, imaging parameters and circulating biomarkers, and that these factors can be used in a risk profile

objective: to assess the risk profile associated with the combined endpoint of all-cause mortality and hf hospitalizations in hf patients with lvef \>0.40. study design: single-center, prospective, study. study population: we aim 200 patients with symptomatic heart failure (nyha class ii-iii), and a recent hf hospitalization, emergency room visit or symptom relief with diuretics who have a left ventricular ejection fraction \>0.40, echocardiographic evidence of left atrial enlargement or left ventricular hypertrophy, and elevated concentrations of bnp or nt-probnp. study procedures: all patients will undergo echocardiography, cardiac magnetic resonance (cmr) imaging, holter recording and blood sampling at inclusion. the 99mtc-hdp scan is optional.there is no control group. total follow up: up to five years. main study endpoint: incidence of the combined endpoint of all-cause mortality and hf hospitalizations.

Eligibility criteria:
inclusion criteria: clinical criteria: 1. age \>18 years 2. written informed consent 3. hf with moderate to severe symptoms nyha ii or iii 4. hospitalization or emergency room visit for hf or symptom relief with diuretics 5. sinus rhythm or af echocardiographic criteria: 1. lvef \>0.40 2. left atrial size (volume ≥29 ml/m2 or la parasternal diameter ≥45), or left ventricular hypertrophy (septal thickness or posterior wall thickness ≥11 mm) or lv diastolic dysfunction (e/e' ≥13 or mean e' septal and lateral wall \<9 cm/s). biomarker criteria: 1. bnp \>31ng/l or nt-pro-bnp\>125ng/l if sinus rhythm 2. bnp \>75ng/l or nt-pro-bnp\>300ng/l if atrial fibrillation exclusion criteria: 1. patients unwilling or unable to sign informed consent 2. patients with a pacemaker or icd 3. indication for icd therapy according to the esc guidelines 4. life expectancy of less than one year 5. significant coronary artery disease or myocardial infarction \< 3 months 6. complex congenital heart disease 7. pregnancy

Keywords: heart failure with preserved ejection fraction hfpef cardiac mri 99mtc-hdp scan
fostering optimal regulation of emotion for prevention of secondary trauma (forest)

Conditions: Burnout; Burnout, Professional; Positive Affect; Depression; Anxiety; Compassion Fatigue; Job Stress

Summary: forest is a positive emotion skills program designed to target mental health and coping needs for frontline violence prevention workers at ucan. ten skills are taught over a period of nine months during existing meetings and wellness activities, as well as in online modules in ucan's learning management system (lms). through infusing the forest skills throughout ucan, we hope to inspire organizational culture change that will emphasize the importance of wellbeing and enhance resilience, therefore reducing burnout and turnover.

all frontline ucan staff will receive the forest program. each month for 9 months there will be a focus on one to two positive emotion skills. the skill(s) of the month will be taught to the staff during existing one-hour wellness meetings/activities, and will be co-facilitated by positive emotion ambassadors (peas; ucan staff members nominated to infuse the skills into ucan culture) and northwestern university. the skill sessions will include didactic content defining the skill and explaining the rationale for inclusion, as well as examples of existing research demonstrating the skills benefits. during the session the group will practice the skill together and discuss ways to use the skill in both work and personal situations. throughout the month, peas will implement the forest skill of the month in other existing meetings, check-ins, and team outings the monthly sessions will be observed by a member of the implementation resource team (irt) who will use a checklist to track that all core pieces of the skill training were delivered. once a month, the irt will meet with the peas for additional training and support. these sessions will be audio recorded for qualitative data on facilitators and barriers to the skill. each month a module in ucan's learning management system (lms) that covers that month's skill(s) will also become available. the lms modules will contain skill-related content similar to what is taught in the skill sessions, including a thorough definition of the skill, examples of ways to utilize the skill, a review or summary of the skill, and several knowledge questions to check for comprehension. the lms content may include text, audio, images, and video components. all ucan frontline cvi staff will be required to complete the lms forest skill module of the month. percentage of staff completing each lms training will be tracked. annual assessments to assess primary and secondary outcomes will be administered via redcap. annual interviews and focus groups will ask for feedback on implementation and content.

Eligibility criteria:
inclusion criteria: * age 18 and over * currently employed by ucan * has internet access * speaks and reads english exclusion criteria: * none

Keywords: burnout anxiety depression positive emotion coping job stress
high dose i-131 metaiodobenzylguanidine(mibg) for metastatic neuroendocrine tumors

Conditions: Neuroendocrine Tumors; Metastases, Neoplasm

Summary: the goal of this clinical research study is to learn if i-131 metaiodobenzylguanidine (mibg) can shrink or slow the growth of the tumor(s) in patients with metastatic neuroendocrine tumors. the safety of this treatment will also be studied.

mibg is used to visualize a group of specific cells in the body. it has been known to deliver the radioactive iodine to the tumor (cancer) cells selectively and result in their destruction. before treatment starts, patients will be evaluated with a tracer scan, using either i-131 mibg or i-123 mibg to locate the tumor site(s). if no mibg accumulation can be found within tumor sites, the patient will not be able to continue on this study. patients will also have ct scans and urine and blood tests. women able to have children will have a pregnancy test. if tumor sites are found and patients are fully eligible, they will receive a therapeutic (treatment) dose of i-131 mibg by vein over 120 minutes. some patients may have to receive a lower dose of mibg. patients will require hospitalization for treatment and will remain hospitalized for about 3-6 days.

Eligibility criteria:
inclusion criteria: * age: 2 years of age and older * sex: male or female; female patients with child bearing potential must have a negative serum hcg pregnancy test within 72 hours prior to treatment; * diagnostic criteria- patients must meet all of the following: 1. histologically documented neuroendocrine tumor. 2. labeled mibg concentration in the tumor site(s) on diagnostic scan. 3. good to excellent performance status. * a patient for whom written voluntary informed consent has been obtained prior to study and participation. * patients can have had prior chemotherapy, as long as hematological parameters meet specifications. * please refer to appendix d drugs and other interactions for list of medications patient needs to cease 2 weeks prior to therapy. patient should check with primary physician after therapy about resuming these medications. * patients with treatment refractory or relapsed advanced or disease not amendable to significant response (\>25% to available chemotherapy) or metastatic disease not amenable to standard therapy. exclusion criteria: * patients with inadequate hematopoietic bone marrow function: anc\<1000 cells/mm3, or platelets\<75k cells/mm3 or hemoglobin\<10g/dl. * patients with impaired renal function: creatinine\>1.5mg/dl. * patients with impaired hepatic function: ast or alt \> 3.0 x upper limit of normal or total bilirubin \> 2.0 mg/dl. * patients with dementia or altered mental status that would prohibit the giving and understanding of informed consent at time of study entry. * female patients who are breast-feeding. * children less than 2 years of age. * patients with previous total body irradiation.

Keywords: metastatic neuroendocrine tumors
ultrasound and chemotherapy of breast cancer: relationship between early vascular changes of the tumor and late tumoral response

Conditions: Breast Cancer

Summary: this study intends to assess the ability of contrast-enhanced ultrasound to make the efficacy of chemotherapy in breast cancer precise. this real-time noninvasive and feasible imaging technique allows us, the investigators at university hospital tours, to evaluate early vascular changes of breast tumors during treatment. these vascular changes may precede long-term tumoral regression. imaging of primary breast lesions may be of value in the prediction of late treatment response. an ultrasound will be performed before the initiation, and after the second and the last dose of chemotherapy. to investigate the changes occurring in the vascularization of tumors, we will use an intravascular ultrasound contrast agent sonovue (sulphur hexafluoride microbubbles). this agent is a microbubbles preparation that is stable, resistant to pressure, and specifically designed to be used as a contrast agent for ultrasound imaging of angiogenesis.

the main objective of the study is to evaluate the early vascular changes of the tumor during neoadjuvant chemotherapy compared to the clinical or mri or histological response.

Eligibility criteria:
inclusion criteria: * breast tumor (size equal to or greater than 3 cm.). patients with diagnosis of benign breast tumor based on biopsy will be excluded from the study after the first ultrasound examination. * neoadjuvant chemotherapy is programmed when an epithelial carcinoma is diagnosed by histology. * performance status = 0, 1 or 2 * no previous surgery or local radiotherapy exclusion criteria: * psychiatric disorders * vital threat due to other disease * vital prognosis \< 3 months * biopsy of the lesion performed within 1 month before the ultrasonography * patient known to have a coronary syndrome * unstable angina and myocardial infarction * acute cardiac failure, class iii/iv cardiac failure * several arrhythmias * acute endocarditis * prosthetic valves

Keywords: contrast-enhanced ultrasound ultrasound contrast agents, microbubbles breast cancer chemotherapy vascularization
repeatability of positron emission tomography (tep) with fluorométhyl-(18f)-diméthyl-2-hydroxyéthyl-ammonium

Conditions: Prostate Cancer

Summary: monocentric study. objective : determination of the repeatability of fluorocholine pet/ct in prostate cancer

a second pet/ct with fluorocholine is performed within 2 weeks after a first examination performed in patient referred for an initial prostate cancer or a biological suspicion of relapse.

Eligibility criteria:
inclusion criteria : * biological suspicion of relapse of prostate cancer or initial staging of prostate cancer * positive pet/ct with fluororocholine exclusion criteria : -none

Keywords: repeatability positron emission tomography (pet) fluorocholine
prevalence of musculoskeletal disorders among monks and nuns in egypt

Conditions: Musculoskeletal Disorders; Prevalence

Summary: 1. sample size will be 400. 2. age starts from 24 years old and more. 3. body mass index ( bmi ) between 18.5 to 24.9 kg/m2 4. years of ordination * (1-3) years novice or probationary * (4-10) years of monasticism. * more than 10 years of monasticism. 5. samples will be selected from several monasteries in egypt. 6. all data collected by arabic version of nordic questionnaire.

study design: observation study - cross-sectional survey. participants: sample size of monks will be 400 subjects of both genders (monks and nuns) randomly selected from different monasteries, participants aged from 24 years old and above thought monastic years. as: * (1-3) years novice or probationary * (4-10) years of monasticism * more than 10 years of monasticism

Eligibility criteria:
inclusion criteria: 1. both genders will include in study. 2. monks and nuns work in different works administration. 3. age starts from 24 years old and more. 4. body mass index (bmi) between 18.5 to 24.9 kg/m2 exclusion criteria: 1. monk or nun had musculoskeletal abnormalities due to causes (congenital or traumatic). 2. monk or nun with previous operation involving locomotor system. 3. outside body mass index range.
online acceptance and commitment therapy for reducing anxiety

Conditions: Anxiety Disorder/Anxiety State

Summary: the main objective of this study is to test the effectiveness of an internet-delivered acceptance and commitment therapy (act) program in reducing anxiety symptoms.

the purpose of this study is to test the effectiveness and level of acceptability of an internet-delivered acceptance and commitment therapy (act) program in reducing symptoms of anxiety. the effectiveness of the intervention will be compared with a wait-list control group using a randomized control trial (rct) design. the participants with high / clinical levels of anxiety from the active treatment group will have the opportunity to read seven act modules and receive personalized feedback for their completed homework assignments. the intervention will be delivered online and participants will have seven weeks to complete the seven modules (we might add one extra week of treatment for all participants in the event they need to compensate the treatment delays accumulated during the previous seven weeks).

Eligibility criteria:
inclusion criteria: * be fluent in romanian * be over 18 years of age * have high levels of anxiety * have access to an internet-connected computer exclusion criteria: * suicidal ideation * substance abuse * severe psychiatric disorders * a recent change in psychotropic medication (i.e., the dose has been changed within the last month)

Keywords: anxiety symptoms/disorders (ocd, ptsd, gad, sad, panic)
cardiac rehabilitation with motivational interview for acute myocardial infarction

Conditions: Myocardial Infarction, Acute

Summary: introduction: secondary prevention after acute myocardial infarction may include cardiac rehabilitation and lifestyle changes. cardiac rehabilitation has mainly taken place in hospitals without coordination with primary healthcare. motivational interviews have been shown to be effective as a means for change in patients after acute myocardial infarction. the objective of this study is to evaluate the effectiveness of a cardiac rehabilitation program with motivational interviews in patients discharged from hospital after acute myocardial infarction. methods: randomized clinical non-pharmacological trial. a minimum sample of 284 participants requiring cardiac rehabilitation after acute myocardial infarction in six primary healthcare centers. participants will be randomized to cardiac rehabilitation with motivational interviews or normal standard of care. all secondary results will be evaluated at 1,3 and 6 months.


Eligibility criteria:
inclusion criteria: * age \>18 years. * hospital admission for acute coronary syndrome (diagnostic codes icd-10: i20-i22). * post unscheduled cardiac revascularization surgery (procedure code icd-10: 021x). * discharge to home with the area of the 7 phcs. * indication of rc indication. * voluntary participation. exclusion criteria: * acute aortic disease, * severe pulmonary hypertension. * uncontrolled arrhythmias. * decompensated heart failure or significant valvular or congenital heart disease. * intervention in heart valves and/or interventricular septum. * diseases that prevent exercise. * osteoarticular disease that severely limits exercise. * severe mental disorder. * any severe psychiatric disorders. * cognitive disability. * verbal communication problems. * participation in hospital cardiac rehabilitation.

Keywords: myocardial infarction cardiac rehabilitation rehabilitation nursing primary health care motivational interviewing
clinical significance of whitnall ligament structure

Conditions: Congenital Ptosis

Summary: prospective clincal study to relate the structure of whitnall ligament in cases of congenital ptosis to the severety of ptosis and the postoperative results.

the study will be a prospective obsevational study. it will include patients (2-16 years old) who will undergo levator resection for simple congenital ptosis correction in ophthalmology department of menoufia university hospital. patients will be divided into 3 groups, 15 patients in each. group i for mild ptosis, group ii for moderate ptosis group 3 for severe ptosis. exclusion criteria included any patients with previous ptosis or any eyelid surgery and patients with a non congenital ptosis. patients included in the study well be informed about the research and the surgical maneuver which will be used with full discussion of all details regarding the postoperative follow up and the potential complications. a written consent in arabic will then be taken from the parents of the patients preoperative assessment will include complete ophthalmological examination including; margin to reflex distance 1 (mrd1), vertical fissure height (vfh), levator function (lf), and eyelid crease shape and position. intraoperative assessment will include whitnall ligament structure assessment including: * the level (the length from the insertion of the levator aponeurosis to whitnall's ligament) * shape (definite band-like, weak string, undifferentiated) * tightness. postoperative assessment will be on scheduled visits at first week, one month, 3 months and 6 months postoperatively and will include mrd1, vfh, lf, and lagophthalmos measurements results will be documented and tabulated and statistically managed.

Eligibility criteria:
inclusion criteria: * congenital ptosis exclusion criteria: * previous ptosis surgery * non congenital ptosis

Keywords: whitnall ligament congenital ptosis levator resection