Kornimate/medical-research-clean huggingface dataset:
assessing the efficacy of a serotonin and norepinephrine reuptake inhibitor for improving meniere's disease outcomes

Conditions: Meniere Disease

Summary: as of yet, the cause of meniere's disease is uncertain and there is no cure. given the lack of high level evidence for treatments, we seek to perform a randomized, placebo-controlled, double-blind, crossover, pilot trial of venlafaxine for treating meniere's disease. venlafaxine is a safe and well-tolerated medication. it has never been trialed in meniere's disease, but there is evidence that it could be effective in helping with vertigo attacks and other aspects of the disorder.


Eligibility criteria:
study subjects will be prospectively recruited from the population of patients presenting with dizziness to our tertiary, multidisciplinary, vestibular-focused, neurotology clinic. subjects must meet the following inclusion criteria: * be 18 years of age or older; * have definite md as defined by the barany society 2015 international consensus statement; * have active md with at least 2 vertigo episodes in the month prior to enrollment; and score at least 36 on the dizziness handicap inventory (dhi), representing at least moderate handicap. patients with the following will be excluded: * other concurrent vestibular or balance disorder (especially those with vestibular migraine-related vertigo episodes despite not meeting diagnostic criteria for vestibular migraine); * currently taking venlafaxine, ssris, or snris; * history of medical (e.g. gentamicin) or surgical (e.g. labyrinthectomy) vestibular ablative treatment; * history of otologic, lateral skull base, or brain surgery; * history of radiation to the head or neck; * known neurologic disorder affecting cognition; * currently taking another serotonin modulating medication; * seizures; * stroke; * myocardial infarction; * hepatic or renal impairment; * hyperlipidemia; * coagulopathy; * psychiatric disorder other than anxiety or depression; * glaucoma; * uncontrolled hypertension; * pregnancy or intention of pregnancy.
neurosensory abnormalities in symptomatic ocular surface patients (nasa)

Conditions: Dry Eye; Neuropathic Pain

Summary: this study is designed to measure how common nerve abnormalities are within a group of patients who feel discomfort within their eyes.


Eligibility criteria:
inclusion criteria: * presents with ocular surface discomfort or for dry eye care * best corrected visual acuity of 20/40 or better in each eye * subject reported duration of symptoms of at least 3 months * 100 subjects will be required to be habitual contact lens wearers as defined by use of contact lenses at least 5 hours per day at least 5 days per week for the last year. exclusion criteria: * use of contact lenses on the day of the visit * pregnant or nursing * irregular corneas (e.g., ectatic disease, transplantation, or corneal dystrophies) * ocular surgery in the past 3 months * ocular infection in the past 3 months * active ocular allergies
evidence-based approach to empower asian american women in cervical cancer screening

Conditions: Uterine Cervical Neoplasms

Summary: this is a randomized trial to evaluate the effects of a community-based intervention on increasing cervical cancer screening rates in underserved asian american (korean, vietnamese, and chinese) women. all women will receive an educational program and navigation assistance. women in the intervention condition will also receive a self-sampling kit for self-collection of a cervical sample for hpv testing. the investigators will evaluate whether the inclusion of a self-sampling kit increases the proportion of asian american women who participate in cervical cancer screening.

aim 1: compare rates of providing a self-collected sample vs. obtaining clinic-based screening among 1100 asian american women. it is hypothesized that the proportion of women in the hpv self-sampling program who provide a self-collected sample will be higher than the proportion of women in the clinic-based program who obtain clinic-based screening. aim 2: examine mediators of participation. the investigators will examine both individual- and social/environmental-level factors associated with participation across both programs. it is hypothesized that higher levels of perceived self-efficacy, lower levels of embarrassment, and fewer barriers will be associated with higher rates of participation in both conditions. further, it is hypothesized that women in the hpv self-sampling program will report greater self-efficacy, less embarrassment, and fewer barriers compared to women in the clinic-based program. aim 3: assess the relative cost-effectiveness of hpv self-sampling vs. clinic-based screening. the investigators will conduct an incremental cost-effectiveness analysis from a societal perspective incorporating trial-based direct medical and participant-borne costs associated with hpv self-sampling vs. clinic-based screening. it is hypothesized that the self-sampling program will be less costly to implement and achieve a higher participation rate.

Eligibility criteria:
inclusion criteria: * women who are of asian race and self-identify as korean, vietnamese, or chinese * are 30-65 years of age * are overdue for cervical cancer screening (e.g., no cytology-based screening within the past 3 years; no hrhpv testing either alone or in combination with cytology in the past 5 years) exclusion criteria: * have a prior diagnosis of cervical cancer or cervical abnormality (e.g., dysplasia) * had a hysterectomy with removal of the cervix * have a compromised immune system (e.g., known hiv) * unable to provide informed consent
nutritional therapy and education with multimedia application in patients with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: the purpose of this study is to evaluate the effectiveness of nutrition therapy in combination with education in diabetes using a multimedia application for improving indicators of metabolic control in patients with type 2 diabetes.

randomized clinical trial. subjects with type 2 diabetes from three family medicine units (primary care), with hba1c \>6.5% and \<13.0%, without advanced macro or microvascular complications of diabetes. two arms: the experimental group with nutrition therapy plus education in diabetes through a multimedia application. the application had seven modules: introduction, nutrition, physical exercise in diabetes, myths and truths on diabetes, metabolic control parameters, knowing diabetes, complications of diabetes. the control group received only usual nutrition therapy. a monthly follow up during the first 7 months and then bimonthly, until 21 months of total follow up, with reinforcement in each visit of nutrition and other non-pharmacological therapy, with control on weight and blood pressure. laboratory studies included hba1c, lipids profile, creatinine and albuminuria, performed at 7, 14 and 21 months. results were provided to both the patient and his family physician, so modification in drug treatment if needed, were performed.

Eligibility criteria:
inclusion criteria: * diagnosis of type 2 diabetes, following ada \& who criteria * without severe marco or microvascular complications of diabetes * hba1c \> 6.5% and \<13.0% exclusion criteria: * inability to or unwillnigness to access the multimedia or to follow dietary recommendations

Keywords: type 2 diabetes mellitus nutritional therapy health education self-management multimedia
comparison of suturing technique types on pubocervical fascia at colpographhy anterior for cystocele repair

Conditions: Pelvic Organ Prolapse

Summary: anterior colporrhaphy is the commonly performed surgery for pelvic organ prolapse. however the success rates of native tissue repair techniques for anterior vaginal prolapse range from %30-%70. according to a systematic review of the anterior colporrhaphy technique, there was no ideal procedure or guideline for gynecologists to perform. the investigators tried to compare pubocervical fascia suturing techniques with the ideal procedure type by determining step by step all parts of the surgery including the anesthesia type. the aim of the study will be to compare the pubocervical fascia reconstruction techniques in the management of anterior compartment defects (pop-q \>2) at 1 year and yearly up to 2 years.

primary and secondary endpoints: primary outcome measures will be the subjective cure of prolapse ("absence or presence of a bulge in the vagina"), objective success with anatomic absence of advanced prolapse at pop-q sites ba, c and bp defined as less than 1 cm individually and as a total. secondary outcome measures include all other parameters such as perioperative outcomes, patient satisfaction, quality of life outcomes, complications, scores on questionnaires, and reoperations. the study protocol will be submitted to the institutional review boards of every participating study site and written informed consent will be obtained from all participants on enrolment. project design: the investigators will perform an international singlecentre single-blind randomized controlled trial by participating in our tertiary referral hospital.

Eligibility criteria:
inclusion criteria: * women with symptomatic stage 2 or greater (point c -1 or more pelvic organ prolapse quantification pop-q) cystocele * women aged between 18-75 years of age exclusion criteria: * women not eligible for surgery for medical or anesthesiological reasons * inability to comprehend questionnaires * inability to give informed consent * inability to return for a review * prior anterior compartment repair with or without mesh * severe cardiovascular or respiratory disease * women who don't want anterior compartment repair * pregnancy * age \<18 years

Keywords: anterior colporrhaphy pubocervical fascia suturing technique cycstocele pelvic organ prolapse
role of bmp pathway in mds progression

Conditions: Myelodysplastic Syndromes; Acute Myelogenous Leukemia

Summary: myelodysplastic syndromes (mds) are hematological cancers that can progress to acute myelogenous leukemia (aml). the involvement of the microenvironment in the maintenance, resistance and evolution of mds is increasingly described. the bone morphogenetic protein (bmp) pathway is involved in numerous functions, including self-renewal of the hematopoietic stem cell compartment and the regulation of hematopoiesis, via interaction with bone marrow stromal cells. investigators have demonstrated its involvement in chronic myeloid leukemia (cml) and aml, in particular via the activation of twist1, δnp73, nanog; it is responsible for an increased state of quiescence of certain cancer stem cells and their resistance. preliminary results based on the analysis of large databases suggest that the bmp pathway is also altered early in mds. this study explores the alteration of this pathway in mds and its involvement in the transformation into aml. if appropriate, the bmp pathway could constitute a very promising therapeutic target to combat transformation into aml.


Eligibility criteria:
inclusion criteria: * adult patients with myelodysplastic syndrome or suspected myelodysplastic syndrome according to the criteria defined by the world health organization or * adult patient with suspicion of de novo acute myeloid leukemia at initial treatment exclusion criteria: * frontier mds/myeloproliferative syndromes including chronic myelomonocytic leukemia * mds and aml having already benefited from cytotoxic treatment including hydroxycarbamide, azacytidine, intensive chemotherapy * patients objecting to their inclusion in the study * pregnant or breastfeeding women * patients under legal protection measure

Keywords: bmp msc mds microenvironment
sexual dysfunction in patients with chronic liver disease

Conditions: Liver Diseases; Liver Cirrhosis

Summary: this project will determine the incidence of sexual dysfunction in patients with chronic liver disease, through questionnaires. the questionnaires have been designed to assess several facets of sexual health, e.g. libido, physical symptoms, depression, etc. 150 patients in our liver outpatient department, and 150 healthy volunteers will be asked to fill in the questionnaire in paper form. the results of this project will be used to produce patient resources, advice sheets and educational materials for patients with chronic liver disease. there is also scope to consider possible interventions in the future to improve sexual dysfunction in patients with chronic liver disease.


Eligibility criteria:
inclusion criteria: * diagnosis of a chronic liver disease (including those who have had liver transplantation) * aged 18-75 * able to give informed written consent exclusion criteria: * major psychiatric disease * patients who lack capacity * patient with no chronic liver disease * patients not proficient in english
dexmedetomidine versus hyalase treatment of carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome; Pain, Chronic

Summary: carpal tunnel syndrome (cts) is a common peripheral entrapment neuropathy, this study aims to investigate if, and to what extent hydro-dissection hyalase and saline versus dexmedetomidine upon the median nerve could offer symptoms and clinical improvement

carpal tunnel syndrome (cts) is the most common compression syndrome the upper extremities. its problem has a high prevalence ranged estimated prevalence of 3.8% in the general population, 3 and 7.8% in the working population. it occurs at any age, especially in individuals in their 40s to 60s, and the male: female ratio is reported to be 3:7. a lot of treatment modalities have been tried to improve the condition, starting from local anesthetic injection, steroid, and up to surgical decompression of the nerves.

Eligibility criteria:
inclusion criteria: * adult patients * complaining of carpal tunnel syndrome of 3 month duration or more * diagnosed axonal neuropathy using electrodiagnosis , nerve conduction study exclusion criteria: * • patient refusal infection at the site of intervention * local anesthetic allergy
serious game-based interventions in patients with mild cognitive impairment outside the clinic

Conditions: Mild Cognitive Impairment

Summary: this study will evaluate the therapeutic efficacy of neuro-world cognitive training games (woorisoft, s. korea) in patients with mild cognitive impairment.

this study will be a cross-over randomized controlled trial. fifty participants will be enrolled and randomly assigned to group a or group b. group a will self-administer neuro-world cognitive training games for 30 minutes a day, twice a week for 12 weeks in the home setting (i.e., intervention period). for the following 12 weeks, the participants will not engage in any therapist-supervised cognitive therapies (i.e., no-intervention period). group b will not engage in any therapist-supervised cognitive therapies (i.e., no-intervention period). for the following 12 weeks, the participants will self-administer neuro-world cognitive training games for 30 minutes a day, twice a week in the home setting (i.e., intervention period). all the participants in both groups will receive phone calls twice a week to 1) provide feedback on their adherence to neuro-world cognitive training (during the intervention period) and 2) learn any significant changes in the level of their daily activities (during the no-intervention period and the intervention period).

Eligibility criteria:
inclusion criteria: * seventeen points or greater and smaller than twenty-six points on the montreal cognitive assessment (moca) * fifty-five years old and above * minimal technological literacy (i.e. ability to use a tablet independently) * having a computer for online videoconferencing-based communication (necessary for online cognitive assessments) exclusion criteria: * confounding neurological and psychiatric disorders * history of traumatic brain injury * clinically known hearing or vision impairment * severe upper-limb motor impairments that could impact the use of mobile devices * clinical presentations suggestive of dementia with lewy bodies, progressive supranuclear palsy, multiple system atrophy, or vascular parkinsonism * diagnosis of dementia * major depression * any significant upper-limb impairment that could affect tablet use * participation in any other therapist-supervised cognitive training
endotracheal intubation during resuscitation

Conditions: Cardiac Arrest

Summary: we hypothesized that the bonfils is beneficial for intubation of manikins while performing cpr. in the current study we compared the performance of the bonfils and the macintosh laryngoscopes with respect to their effectiveness and time to successful eti during chest compression (cc) using an adult manikin.


Eligibility criteria:
inclusion criteria: * give voluntary consent to participate in the study * minimum 1 year of work experience in emergency medicine * experienced emergency medical personnel (paramedics, nurses, physicians) exclusion criteria: * not meet the above criteria * wrist or low back diseases

Keywords: intubation, endotracheal
mortality causes in rib surgery patients

Conditions: Flail Chest; Rib Fractures; Thoracic Injuries; Pulmonary Contusion; Blunt Trauma

Summary: this study retrospectively investigates the causes of mortality and morbidity in patients undergoing rib fracture surgery due to blunt trauma. the primary objective is to determine whether pulmonary contusion or associated extrathoracic trauma plays a more significant role in adverse outcomes. data collected includes patient demographics, trauma mechanisms, associated injuries, surgical timing, and clinical outcomes. the study aims to provide insights into improving management strategies for trauma patients and reducing complication rates through early identification and tailored interventions.

this retrospective study investigates the underlying causes of morbidity and mortality in patients who underwent rib stabilization surgery due to blunt trauma-induced rib fractures. the primary objective is to determine whether pulmonary contusion or associated extrathoracic trauma plays a more significant role in adverse outcomes such as pneumonia, prolonged air leaks, tracheostomy, wound infections, and mortality. the study includes patients diagnosed with flail chest who underwent rib stabilization surgery between january 1, 2014, and january 1, 2024, at a single tertiary care center. collected data encompasses patient demographics, trauma mechanisms, associated injuries (thoracic and extrathoracic), surgery timing (early vs. late stabilization), ventilator settings, extubation duration, intensive care unit (icu) and hospital length of stay, laboratory parameters, and clinical outcomes. key outcomes include the incidence of morbidity (e.g., pneumonia, prolonged air leak, wound infections) and mortality. statistical analyses will evaluate the relationship between these outcomes and factors such as the severity and timing of injuries, surgery timing, trauma mechanisms, and associated injuries. the study aims to provide valuable insights into optimizing the management of flail chest patients, emphasizing the importance of early rib stabilization and a multidisciplinary approach. these findings are expected to contribute to the development of standardized protocols for patient selection and intervention timing, potentially improving patient outcomes in multitrauma settings.

Eligibility criteria:
inclusion criteria: * patients aged 18-80 years diagnosed with flail chest following blunt trauma who underwent rib stabilization surgery * those with complete clinical and laboratory data * those with at least 30 days of follow-up after surgery. exclusion criteria: * patients under 18 years of age * flail chest patients who did not require rib stabilization surgery * patients with incomplete clinical or laboratory data * those with penetrating thoracic trauma.

Keywords: flail chest rib fractures pulmonary contusion multiple trauma
treatment of pulmonary hypertension 1-us study

Conditions: Pulmonary Arterial Hypertension

Summary: the objective of this study is to assess the safety, performance and initial effectiveness of the tivus™ system when used for pulmonary artery denervation through subjective and objective change in clinical parameters and haemodynamic evaluation. this is a prospective, multi-center, non-randomized, open-label clinical trail. the study will be conducted in up to 4 centers and will recruit up to 15 patients diagnosed with pah, functional class iii who have stable pah on a stable drug regimen of two pulmonary arterial hypertension specific medications.


Eligibility criteria:
inclusion criteria: * patient with known pulmonary arterial hypertension (pah), diagnosed as idiopathic pah, connective tissue disease pah, anorexogen induced or heritable pah * pah diagnosis confirmed by hemodynamic evaluation performed prior to screening and showing all of the following: mean pulmonary artery pressure (mpap) ≥25 mmhg at rest; pulmonary capillary wedge pressure (pcwp) or left ventricular end diastolic pressure (lvedp) ≤15 mmhg; pulmonary vascular resistance (pvr) at rest \>3 wood units; not meeting the criteria for a positive vasodilator response (fall in mpap ≥ 10 mmhg to ≤ 40 mmhg). * patient with a current diagnosis of who functional class iii * patient taking two pulmonary arterial hypertension specific medications other than parenteral prostanoids * patient is adhering to a stable drug regimen (i.e., with no changes of dose or medication for a minimum of 3 months prior to enrollment) * patient with egfr levels of ≥ 30 ml/min/1.73m2or serum creatinine levels of ˂ 150µmol/l exclusion criteria: * patients who are treated with parenteral prostanoids * pregnant women or women planning a pregnancy within 12 months of study enrolment * patient with significant co-morbid condition(s) which, at the discretion of the pi, are deemed to prohibit study entry * patient with life expectancy of less than a year * concurrent enrollment in another device or drug trial except for observational studies (unless specifically approved by the sponsor) * patient with pulmonary artery anatomy that precludes treatment * patient with moderate to severe pulmonary artery stenosis * patient with any pulmonary artery aneurysm * patient who has experienced a myocardial infarction, unstable angina pectoris, or a cerebrovascular accident in the previous 6 months * patient who has implantable cardiac pacemakers, icds, neurostimulators, or drug infusion devices * patients who are unable to undergo an mri scan
bupivacaine vs oxybuprocaine topical anesthesia in ivi

Conditions: Pain, Acute

Summary: comparing two local anaesthetic agents, bupivacaine 0.5% versus oxybuprocaine used topically to provide surface anaesthesia before ivi procedures.

in preparation zone, we will cannulate the patients, connect them to the pulse oximetry and we will start providing appropriate surface anaesthesia for an adequate period of time before the patient administration of the injection, by applying the anaesthetic agents, 3 times with 5 minutes interval, for 15 minutes and then waitng the injection all patients are informed that they are going to receive topical anaesthetic agent before the ivi. pain is monitored during the injection by using the 11 points verbal numerical pain scaling as zero is for no pain and 10 is for severe unbearable pain.

Eligibility criteria:
inclusion criteria: * all patients between 30 to 70 years exclusion criteria: * uncooperative patients