Kornimate/medical-research-clean huggingface dataset:
evaluation of airway pressure release ventilation in covid-19 ards

Conditions: ARDS; COVID19

Summary: the 2020 pandemic of the coronavirus (sars-cov2) has lead to an increase in ards cases requiring invasive mechanical ventilation in the icu (intensive care unit). the investigators hypothesize that airway pressure release ventilation (aprv) could be beneficial in patients with ards secondary to sars-cov2 viral pneumonia.

lung protective mechanical ventilation is the cornerstone of ards management, reducing the work of respiratory muscles and optimizing gas exchange. however, it can be the source of deleterious effects, grouped under the terms of ventilator induced lung injury (vili) and ventilator induced diaphragm dysfunction. the protective ventilatory strategy has led to a significant improvement in the prognosis of ards patients, by reducing the volume of the air and oxygen mixture (lower tidal volume) delivered to the lungs and thus reducing the pulmonary stress and strain. however, this protective ventilation usually requires deep sedation and neuromuscular blockade to avoid deleterious patient-ventilator asynchrony. airway pressure release ventilation (aprv) has been proposed to reduce patient-ventilator asynchrony and reduce the vili. the operating principles of aprv are based on the presence of two pressure levels that are kept constant. spontaneous breathing is possible at any time at both pressure levels if the patient is not deeply sedated or under neuromuscular blockade. the investigators hypothesize that aprv mode could be beneficial on oxygenation and respiratory work in patients with ards secondary to sars-cov2 viral pneumonia.

Eligibility criteria:
inclusion criteria: * patients treated in nancy university hospital between 01/04/2020 and 31/06/2020 for covid-19 ards, requiring invasive ventilation * trial of airway pressure release ventilation during the icu stay exclusion criteria: * patients requiring veno-venous ecmo * patients unable to complete the 6-hour aprv trial due to poor tolerance : spo2 decrease \ 35), hypercapnia (ph \ 60mmhg)

Keywords: airway pressure release ventilation intensive care unit sars-cov-2 aprv acute respiratory failure
effect of lanconone in weight-bearing joint pain

Conditions: Osteo Arthritis Knee

Summary: the current study has been designed to primarily assess the effect of lanconone® in comparison to placebo on pain in weight bearing joints.


Eligibility criteria:
inclusion criteria: 1. bmi ≥ 25 and ≤ 29.9 kg/m2. 2. with unilateral or bilateral oa of the knee for at least greater than 3 months, as presented by pain in the knee at least for last 3 months. 3. post-menopausal females (lmp at least 12 months prior to the screening). exclusion criteria: 1. history of osteoarthritis for more than 3 years. 2. systolic blood pressure ≥140 mm hg and diastolic blood pressure ≥ 90 mm hg 3. fbs\>140 mg/dl. 4. smokers or chronic alcoholics. 5. participants planning to travel in the next 56 days or engage in any non-routine activity that is likely to strain the knees.
yoga on posttraumatic growth and quality of life

Conditions: Posttraumatic Growth; Quality of Life

Summary: the objective of this study is to examine the effect of yoga on posttraumatic growth and quality of life. the birth action, which includes positive and negative experiences, can be an important opportunity to achieve posttraumatic growth and improve the quality of life. this is a experimental model with pretest-posttest control group study. two hundred and fifty-two women who met the criteria for inclusion in the study made up the research population. three instruments were used to obtain the research data: personal information form, posttraumatic growth inventory (ptgi) and sf-36 quality of life questionnaire (sf-36).

failure in modern medicine approaches or side effects of treatments and drugs, as well as the woman's anxiety to hurt herself and her baby direct her and her relatives to try complementary therapies. women should prefer natural ways in coping with these postpartum problems rather than seeking medical advice. when yoga and meditation, which are included in the group of mind-body-based complementary therapies, are performed in the postpartum period, they will help to relieve tensions and distresses that accumulate during birth, strengthen the pelvic floor, heal perineum, bring reproductive organs back to their prepregnancy condition healthily, provide the mother and the infant a sleep pattern, and have an easier transition to sleep.

Eligibility criteria:
inclusion criteria: * having a baby between 2 and 6 months * first time mom * no tissue deformity in extremities exclusion criteria: * any gynecological disease * any psychiatric illness * using any psychiatric medication
inulin-type fructans-rich vegetables, obesity, gut microbiota

Conditions: Obesity

Summary: the purpose of the study was to evaluate the effect of a diet based on itf-rich vegetables in combination with purified itf supplementation on weight management, metabolic alteration and gut microbiota composition. obese patients were treated for 3 months and several parameters were measured before and after the study period.


Eligibility criteria:
inclusion criteria: * body mass index \> 30 kg/m² * caucasian * presence of at least one of the following comorbidity : prediabetes, diabetes, dyslipidemia, hypertension, steatosis. exclusion criteria: * psychiatric problems or use of antipsychotic * consumption of antibiotics, pro/prebiotics, fibre dietary supplement, or any molecules that modifies the intestinal transit (\<6 weeks) * pregnancy in progress or planified within 6 months * specific dietary practise (vegetarian, vegan,...) * specific dietary treatment (\<6 weeks) (e.g. high protein diet) * type 1 diabetes * excessive alcohol consumption (\>3 glasses/day) * inconclusive acceptability test (regarding the protocol of the intervention and the vegetables used in the protocol)
polycolistin e sodium mesylate combined with intravenous atomization for carbapenem resistant gram-negative bacteria in pulmonary infection

Conditions: Lung Infection Bacterial

Summary: pulmonary infection is a kind of infectious disease that seriously damages human health. it usually starts quickly and progresses rapidly in clinical manifestations, and is often accompanied by upper respiratory tract infection symptoms. with the increasing use of broad-spectrum antibiotics in clinical practice, the failure of anti-infection caused by drug-resistant bacteria is more and more common. once a patient develops carbapenem-resistant gram-negative bacteria (cro) infection, there are limited drug options. therefore, hap, as a serious and common complication, has a high incidence and mortality for icu patients. in this study, patients who met the diagnostic criteria for pulmonary infection caused by cro that was clearly or strongly suspected to be resistant to carbapenems but sensitive to cms were selected, and the combined treatment regimen of cms intravenous atomization was adopted. to explore the therapeutic effect of cms combined with intravenous atomization in patients with carbapenem resistant gram-negative bacteria in lung infection. to evaluate the safety and tolerability of the combination regimen in patients with pulmonary infections caused by cro. the purpose of this study was to explore the efficacy and safety of cms combined with intravenous atomization in the treatment of patients with cro induced pulmonary infection, and to provide a basis for its clinical rational application.


Eligibility criteria:
inclusion criteria: 1. voluntarily participate in the study and sign the informed consent; 2. inpatients aged 18-80 years old, regardless of gender; 3. patients who met the diagnostic criteria for pulmonary infection in the guidelines for the diagnosis and treatment of hospital-acquired pneumonia and ventilator-associated pneumonia for adults in china (2018 edition); 4. infections caused by gram-negative bacteria (cro) that are known or strongly suspected to be resistant to carbapenems but sensitive to cms. exclusion criteria: 1. age \> 80 years old; 2. the patient had a history of severe allergy or hypersensitivity to polymyxins; 3. patients with serious dysfunction of heart, liver, kidney and other important organs; 4. patients with serious diseases such as malignant tumors and blood system diseases; 5. patients with low immune function and risk of opportunistic pathogen infection; 6. patients who used excessive colistin intravenous or atomized inhalation therapy within 72h before enrollment; 7. have participated in other clinical trials within three months; 8. pregnant or breastfeeding women; 9. there are other circumstances that the researcher believes are not suitable for inclusion.
diagnostic test for endometrial receptivity 24 hours before embryo transfer

Conditions: Infertility

Summary: this clinical validation study is being carried out to validate the efficacy of a test measuring the clinical application of prostaglandins present in the endometrial fluid in patients, 24 hours before the embryonic transfer. this test is capable of predicting endometrial receptivity without the need of performing a biopsy.


Eligibility criteria:
inclusion criteria: * any ivf patient being treated for single or double embryo transfer * bmi: 20 - 30 * normal ovarian response (7 - 8 ovocitos) in ivf treatment with afc ≥ 8, (afc = antral follicle count) * elective embryo transfer * normal uterine cavity * age: ≤ 38 years old for patients with own oocytes; ≤ 50 years old for patients with donated oocytes. exclusion criteria: * patients with recurrent miscarriages ( ≥ 2 biochemical miscarriages; ≥ 2 clinical miscarriage) * patients with severe male factor ( ≥ 2\*106 espermatozoides/ml).
efficacy and safety of deep brain stimulation (dbs) of the pallidal (gpi) in patients with tardive dystonia

Conditions: Dystonia; Movement Disorder

Summary: the purpose of this randomized, double blind, multi-center study is to assess the efficacy and safety of bilateral pallidal deep brain stimulation in patients with tardive dystonia.

deep brain stimulation (dbs) has been established as a new reversible, neurosurgical therapeutic option for patients suffering from disabling neurological movement disorders such as essential tremor and parkinson´s disease. recently, deep brain stimulation has been successfully applied in patients with primary generalized and segmental dystonia. additionally, a number of case reports suggest that pallidal deep brain stimulation may also improve tardive dystonia, which may for instance result from the intake of neuroleptics and which is notoriously difficult to treat medically. the present study will investigate the effects of pallidal dbs using a double blind, randomized design (sham- versus verum-stimulation within a 3-months interval post implantation of the electrodes). initially 60 patients had been calculated in a power analysis to assess significant results based on an average improvement of dystonic symptoms of 30%. however, in a recent study (damier et al., archives of general psychiatry, 2007), 10 out of 10 showed a successful outcome of approximately 50% decrease on the extrapyramidal symptoms rating scale score. the exact one- sided lower 95% confidence limit would be 0.794 for this result. if such an approach is chosen for sample size estimation with 18 verum and 18 placebo patients one would obtain a power of 82% against a placebo effect of 30% success rate. for a placebo effect of 25% one needs 16+16 patients and for the placebo effect of 20% one needs 12+12 patients. we thus decided to reduce the sample size to 36- 32- 24 patients. it is expected that the continuous primary outcome measure will preserve even higher power than the binary one used in the study mentioned above. the local ethical committee has approved this.

Eligibility criteria:
inclusion criteria: * operational criteria for tardive dystonia for \> 18 months after cessation of neuroleptic exposure * 18-75 years * relevant functional impairment in daily living activities * bfmdrs \> 8 or aims \> 16 * informed written consent exclusion criteria: * panns \>60 (schizophrenia) * hamilton-score \> 18 (depression) * mattis-score \<120 (dementia) * preceding stereotactic neurosurgery * pronounced brain atrophy * increased bleeding risk * decreased immune status * botulinum toxin treatment within the last 3 months

Keywords: deep brain stimulation pallidum tardive dystonia randomized double blind multicenter
improving cancer foci detection in prostate cancer using multiparametric mri/mrs

Conditions: Prostate Cancer

Summary: the investigators' goal is to develop a non-selective and non-invasive procedure to identify aggressive tumors and simultaneously identify their exact location in prostate cancer patients undergoing radical prostatectomy by combining multiparametric mri and machine learning techniques. the combination of multi-parametric mri and machine learning (validated using histopathology) can lead to increased sensitivity and specificity of cancer foci in the prostate, and help in isolating aggressive from indolent tumors. this increased sensitivity and specificity may eventually lead to: a) a reduction in the number of patients that undergo unnecessary treatment, and b) enhance current treatment options by enabling the use of focused therapies. the investigators will recruit 15 patients with prostate cancer that are currently scheduled to undergo radical prostatectomy into the study. all patients will obtain an advanced mri study prior to the radical prostatectomy. mri scans will include a) high-resolution volumetric images using t1 and t2-weighted imaging, b) vascular images using dynamic contrast enhanced (dce) imaging, c) biophysical microstructure images using diffusion-weighted imaging, and d) biochemical images using mr spectroscopic imaging. following radical prostatectomy, a pathologist will grade the prostatectomy specimens based on standard of care (gleason grading system). correlations will be generated between the parameters obtained from scans and from clinical assessments.


Eligibility criteria:
inclusion criteria: 1. all male patients that have opted for radical prostatectomy 2. subjects must be capable of giving informed consent. 3. subjects must not be claustrophobic. exclusion criteria: 1. subjects with pacemakers. 2. subjects who have metallic ferromagnetic implants or pumps. 3. all females are excluded from this study. 4. subjects with kidney disease of any severity or on hemodialysis. 5. subjects with known allergies to gadolinium-based contrast agents. 6. subjects incapable of lying on their backs for up to an hour at a time.

Keywords: prostate cancer mri/mrs
evaluating alcohol use in alcoholic liver disease

Conditions: Alcoholic Liver Disease

Summary: this prospective, analytic observational study will investigate alcohol recidivism in patients with alcoholic liver disease. all adult subjects presenting with alcoholic liver disease are considered for inclusion. subjects able to give consent are included.

this is a longitudinal observational study. subjects with a diagnosis of alcoholic liver disease (acute alcoholic hepatitis or alcoholic cirrhosis) who present to weill cornell medical center or columbia university medical center new york presbyterian hospital or the gastroenterology and hepatology clinic will be invited to join this study, which entails a survey at baseline and follow-up at 3, 6, 9, 12, 15, and 18 months and then at 2, 5, and 10 years. follow-up will consist of a chart review, a phone or in person interview, and most recent clinic visit interview for alcohol recidivism. the clinical providers will be blinded to the survey results.

Eligibility criteria:
inclusion criteria: * alcoholic liver disease able to consent exclusion criteria: * without alcoholic liver disease unable to consent
out-of-hospital cardiopulmonary resuscitation and aed feedback

Conditions: Cardiac Arrest; Resuscitation

Summary: the purpose of this study is to determine whether an online automatic feedback improved cpr quality (no-flow time, compression depth, short-term survival and one year follow up) in this prospective randomised study of out-of-hospital cardiac arrest


Eligibility criteria:
inclusion criteria: * cardiac arrest exclusion criteria: * age under 18 years

Keywords: aed (automated external defibrillation) feedback out of hospital resuscitation
comparison study on hair apposition technique performed between nurses and doctors in emergency department.

Conditions: Scalp Laceration

Summary: the purpose of this study is to compare the effectiveness, complications and benefits of hair apposition technique(hat)performed by nurses or doctors.

hair apposition technique (hat) is a relatively new technique for treating certain scalp lacerations. it has been shown to be equally acceptable as compared to the standard toilet and suture. this procedure has been the technique of choice for suitable scalp lacerations in department of emergency medicine, singapore general hospital (dem, sgh) and emergency medicine department, national university hospital (emd, nuh). currently hat is being performed by doctors in the respective hospitals. nurses, on the other hand, are routinely using tissue adhesives for minor wound closure. however, nurses in kandang kerbau women and children hospital (kkwch) have been routinely using hat for 1 year now. studies had been also been done by nurses in treating of minor wounds using various tissue adhesives as well as hair knotting technique.the trend of nurses handling minor wounds with tissue adhesives, hair knotting technique as well as hat suggested the possibility of nurses performing hat to a degree as competent as a doctor. this study aims to compare the effectiveness, complications and benefits hat performed between nurses and doctors in the emergency department.

Eligibility criteria:
inclusion criteria: * all age group * linear lacerations of scalp * lacerations less than 10cm in length * hair at least 3cm in length exclusion criteria: * severely contaminated wounds * actively bleeding wounds * patients with unstable vital signs or altered mental state

Keywords: scalp laceration tissue adhesive wound care cost effectiveness
transhepatic arterial chemotherapy (tac) versus transcatheter arterial chemoembolization (tace) plus folfox4 as the treatment of unresectable liver metastasis of colorectal cancer

Conditions: Liver Metastasis; Colorectal Cancer

Summary: the purpose of this study is to investigate whether tac plus folfox4 or tace plus folfox4 are able to improve resection rate and overall survival in patients receiving primary colorectal tumor resection than given folfox4 only.

we administered three cycles folfox4 plus tac(oxaliplatin,fudr and mmc) or folfox4 plus tace(oxaliplatin,fudr,mmc and embolision) to primary colorectal tumor resected patients with unresected liver metastasis. the study endpoints were resection rate of liver metastasis, progression-free survival, overall survival as evaluated by intent-to-treat analysis.

Eligibility criteria:
inclusion criteria: * age \< 75 years with histologically proven adenocarcinoma of the colon or rectum * no severe major organ dysfunction * who performance status of 0 or 1 * no prior cancer therapy * with measurable unresectableliver metastasis * without other metastasis exclusion criteria: * age \>= 75 * severe major organ dysfunction * who performance status of \>1 * prior cancer therapy * with other metastasis

Keywords: liver metastasis colorectal cancer oxaliplatine transartery chemotherapy embolision unresectable liver metastasis of colorectal cancer
a study of the safety and effectiveness of jnj-39758979 in the treatment of adults with persistent asthma

Conditions: Asthma

Summary: the purpose of this study is to evaluate the safety and effectiveness of once daily oral administration of jnj-39758979 in the treatment of adults (18 to 65 years of age) with persistent asthma.

this is a multicenter, double-blind (neither physician nor participants knows the treatment that the participant receives), randomized (study medication is assigned by chance), placebo-controlled (an inactive substance is compared with a medication to test whether the medication has a real effect in a clinical study), parallel group (each group of participants will be treated at the same time), exploratory study (jnj-39758979 is introduced in participants with asthma for the first time). this study consists of 4 phases: screening phase (4 weeks prior to the start of the run-in period), placebo run-in phase (2 weeks prior to the start of treatment phase), double-blind treatment phase (12 weeks), and posttreatment phase (5 weeks). approximately 100 participants will be randomly allocated to 1 of 2 treatment groups: treatment a (participants will receive jnj-39758979 once daily) and treatment b (participants will receive placebo once daily). safety will be evaluated by assessment of adverse events, clinical laboratory tests, vital signs, physical examination, and 12-lead electrocardiogram. total study duration for each participant will be approximately 23 weeks.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of asthma for at least 6 months * short-acting beta-agonist use greater than or equal to 5 times in the 2 weeks prior to screening * healthy on the basis of physical examination, medical history, vital signs, and 12 lead ecg performed at screening * having adequate laboratory values * no history of/active or latent tuberculosis * agree to use protocol defined contraceptive methods exclusion criteria: * history of life-threatening asthma attack requiring hospitalization for asthma within 5 years of screening, or emergency department treatment of asthma within the last month * moderate or severe renal insufficiency * cigarette smoking within the last year - viral or bacterial vaccination within the last month (eg, flumist) * human immunodeficiency virus (hiv) or hepatitis b or c positive

Keywords: asthma persistent asthma adults with persistent asthma chronic asthma jnj-39758979 placebo
a randomised pilot study to assess differences in stimulation induced paresthesia between 2 spinal cord stimulation systems

Conditions: Chronic Pain

Summary: 12-smi-2014 is a post-market, randomised, pilot study to identify and rate differences in patient experiences with two different types of spinal cord stimulator devices which are routinely used to treat chronic pain.


Eligibility criteria:
inclusion criteria: 1. subject is appropriate for scs implantation according to standard criteria 2. subject is \>18 to \<75 years old 3. subject is able and willing to comply with the follow-up schedule and protocol 4. subject has chronic (\> 6 months) uni/bi-lateral neuropathic pain in the lower limb(s) (below the knee) with predominant foot pain 5. minimum baseline pain rating of 50 mm on the vas in the primary region of pain 6. subject is able to provide written informed consent exclusion criteria: 1. subject has no other exclusion criteria for scs implantation according to standard criteria 2. subject has had corticosteroid therapy at an intended site of stimulation within the past 30 days 3. subject has had radiofrequency treatment of an intended target drg within the past 3 months 4. subject has participated in another clinical study within 30 days 5. subject has been previously treated with and failed to respond to an implantable neuromodulation therapy