Kornimate/medical-research-clean huggingface dataset:
investigational study to evaluate the dpp® syphilis screen & confirm antibody point-of-care test (poct) to diagnose infectious syphilis

Conditions: Syphilis

Summary: the goal of this observational study is to evaluate the sensitivity, specificity, and utility of the dpp® syphilis screen \& confirm antibody point-of-care test (poct) to diagnose infectious syphilis in participants attending the nine circles community health centre in winnipeg, manitoba. the main questions are: does the poct provide accurate results compared to conventional syphilis serology methods? and can the use of poct improve the timeline for diagnosis and treatment of syphilis? researchers will compare the poct results with conventional laboratory testing to assess if the rapid test can reliably diagnose syphilis during the initial clinic visit. participants will: provide a blood sample via fingerstick for poct testing and complete a feedback survey to evaluate the poct experience. key details: this study will involve approximately 600 participants aged 18 and older over the course of 12 months which includes both new and repeat visits


Eligibility criteria:
inclusion criteria: * individuals attending the clinic for routine sexual health care and requiring syphilis testing as part of this care * be able to provide informed consent and are a minimum 18 years of age are eligible for this study * those who had other stis in the past, or being suspected of having other stis, are not excluded as long as testing for syphilis is part of the care provided to them exclusion criteria: * those who, at the discretion of the hcp/research nurse, appear intoxicated and/or with extreme distress, or confused, will be excluded * those below the age of 18 years * if it has been less than 90 days since their last poct study visit and they are asymptomatic.

Keywords: syphilis point of care test serology
study of blood levels of ceftaroline fosamil in children who are receiving antibiotic therapy in the hospital

Conditions: Infections

Summary: the purpose of this study is to assess blood levels of ceftaroline fosamil in children.

to characterize single dose pharmacokinetics of ceftaroline fosamil in children.

Eligibility criteria:
inclusion criteria: subjects must meet the following inclusion criteria: * male or female children with ages from birth to younger than 12 years * hospitalized and receiving systemic antibiotic therapy for treatment of a suspected or confirmed infection * sufficient intravascular access * negative urine pregnancy test * written informed consent from parent(s)and verbal informed assent from subject exclusion criteria: subjects must not meet any of the following exclusion criteria: * history of any hypersensitivity or allergic reaction to any β-lactam antimicrobial * past or current history of epilepsy or seizure disorder * moderate or severe renal impairment * if female, currently pregnant or nursing * aspartate aminotransferase, alanine aminotransferase, or total bilirubin level \> 3 times upper limit of normal * any condition that would make the subject, in the opinion of the investigator, unsuitable for the study * use of probenecid within 3 days prior to dosing * receipt of a blood transfusion during the 24-hour period before enrollment

Keywords: confirmed or suspected infections
impact of ckd on children and their families

Conditions: CKD (Chronic Kidney Disease) Stage 5D

Summary: based on the available literatures, previous studies have investigated the impact of ckd and dialysis on patient's health among adult and elderly population. as far as we know, this is the first empirical study that investigates the impact of ckd on children functional capacity and their families qol.

the current study will be done to investigate the long term effect of the ckd itself on different dimensions of the child health to understand the unique characteristics of pediatric ckd. also, it will be beneficial for designing a comprehensive physical therapy protocol for prevention of different complications and to improve their wellbeing healthcare. additionally, it will be beneficial to determine the family and parental stresses and to build the rehabilitation plan for the child considering the possible family issues regarding the child condition.

Eligibility criteria:
inclusion criteria: * age from eight to twelve years. * both genders. * diagnosed with esrd (stage 5) based on the glomerular filtration rate (gfr \< 15 ml/minute/1.73 m2). * able to understand and follow instructions during assessment procedures. * willing to participate in the study and attend the assessment procedures. exclusion criteria: children of the following criteria will be excluded from the study: * cardiopulmonary disorders * uncontrolled hypertension * unstable angina * severe uncontrolled diabetes * neurological or cognitive disorders with functional deficits * significant cerebral or peripheral vascular disease.

Keywords: ckd hemodialysis functional capacity qol
safety, effectiveness and patient acceptance of the treatment with mabcampath in chronic lymphocytic leukemia

Conditions: Chronic Lymphocytic Leukemia

Summary: this study will collect data on safety, effectiveness and patient acceptance of mabcampath treatment under daily life conditions.

as of 29 may 2009, the clinical trial sponsor is genzyme corporation. note: this study was originally posted by sponsor schering ag, germany, which was subsequently renamed to bayer schering pharma ag, germany.

Eligibility criteria:
inclusion criteria: in- and outpatients suffering from cll, who are treated with mab campath, and are routinely monitored with pcr (polymerase chain reaction) for cmv infection during mabcampath treatment and for at least 2 months following completion of treatment. exclusion criteria: in accordance with summaries of product characteristics (spc).

Keywords: cll alemtuzumab
effectiveness of a hybrid cardiac rehabilitation program

Conditions: Cardiovascular Diseases

Summary: the goal of this pragmatic randomized clinical trial is to compare the effectiveness of a hybrid model of cardiac rehabilitation with a centre-based program in people with cardiovascular disease. the main question it aims to answer is: • how effective is a hybrid model of cr for people with cardiovascular disease living in a francophone minority community compared to a centre-based model of cr in terms of leading to maintenance of gains (physical activity level, functional capacity, mental health, quality of life) six months after cr? participants will undergo a 12-week hybrid cardiac rehabilitation program. for the first six weeks, patients will be required to attend the hospital twice a week. after that, there will be a gradual increase in home sessions for the remaining six weeks. when a patient has a home session, health professionals will follow up with a weekly phone call. researchers will compare the centre-based cardiac rehabilitation program with the hybrid program to see if the hybrid program can better maintain the level of physical activity, mental health, functional capacity, and quality of life six months after the end of the program.


Eligibility criteria:
inclusion criteria: * be and adult (over 19 years old) * be eligible for vitalité health network cardiac rehabilitation program. exclusion criteria: * have a physical or cognitive condition that precludes participation in an exercise program. * have previously participated in a cr program.

Keywords: cardiac rehabilitation hybrid randomized controlled trial physical activity long term
become patients in the emergencies of uhc poitiers

Conditions: Emergencies

Summary: the number of consultations in the emergency services has continued to increase with 19.7 million passages in 2014, an increase of 4% compared to 2013. among these admissions, many patients come spontaneously to the emergency department and others are sent by the general practitioner who remains the first resort in the care of the patient. faced with this massive influx to emergency services, the investigator will see what is the future of these. are they more likely to be hospitalized than patients presenting to emergencies on their own?


Eligibility criteria:
inclusion criteria: * major patient * view by a general practitioner whether he is their doctor or a substitute * addressed with a mail * all types of pathologies are taken into account exclusion criteria: * minor patient
studying genes in samples from younger patients with relapsed acute lymphoblastic leukemia

Conditions: B-cell Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia

Summary: this laboratory study is looking into genes in samples from younger patients with relapsed acute lymphoblastic leukemia. studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in dna and identify biomarkers related to cancer. it may also help doctors find better ways to treat cancer.

objectives: i. to identify global changes in the epigenome and various underlying histone modifications that characterize relapsed acute lymphoblastic leukemia (all). ii. to identify specific transcription factor-binding sites associated with histone alterations. iii. to correlate gene expression changes of differentially regulated genes at relapse with underlying chromatin modifications. outline: archived bone marrow samples, collected at the time of diagnosis and relapse, are analyzed for gene expression and histone modifications by microarray, chromatin immunoprecipitation (chip) sequencing, and quantitative real-time polymerase chain reaction (qrt-pcr).

Eligibility criteria:
inclusion criteria: * diagnosis of b-cell acute lymphoblastic leukemia * paired diagnosis-relapse primary patient samples obtained from the children's oncology group (cog) cell bank
study of ptpn22 c1858t polymorphism in children and adolescents of greek origin with t1dm

Conditions: Type 1 Diabetes Mellitus

Summary: the protein tyrosine phosphatase non-receptor type 22 (ptpn22) gene encodes a lymphoid-specific phosphatase (lyp) which is an important downregulatory factor of t cell activation. a ptpn22 polymorphism, c1858t, was found associated with t1dm in different caucasian populations. in this observational case-control study, we aimed at confirming the role of ptpn22, c1858t polymorphism in t1dm predisposition in a greek population.


Eligibility criteria:
inclusion criteria: for the patients * diagnosis of t1dm according to american diabetes association (ada) criteria as well as according to international society for pediatric and adolescent diabetes (ispad) guidelines * unrelated male and female subjects * 1-20 years of age * come from greece (at least 3 grandparents are greek) * at least one year post onset of t1dm * sign written informed consent inclusion criteria: for the controls * unrelated nondiabetic male and female subjects with no family history of t1dm * equal to or greater than 18 years of age * come from greece (at least 3 grandparents are greek) * be screened by a questionnaire to ensure the absence of any diagnostic evidence of autoimmune diseases or family history (first- or second-degree relatives) of t1dm * sign written informed consent exclusion criteria: for the patients •subjects who do not meet the criteria above exclusion criteria: for the controls •subjects who do not meet the criteria above
tongue edema caused by intubation tube in intensive care unit patients

Conditions: Tongue Edema; Tongue Enlarged; Mechanical Ventilation Complication; Intubation Complication

Summary: tongue edema (te) is an enlargement of the tongue that can be noticed with the naked eye and protrudes from the mouth. endotracheal intubation tube, which can exert high pressure on the tongue for a long time, may cause te. this study was aimed to detect te, which may develop due to long-term pressure application of the intubation tube to the tongue, in patients hospitalized in the intensive care unit (icu) who underwent endotracheal intubation by submental ultrasonography (usg) method.

tongue edema (te) is an enlargement of the tongue that can be noticed with the naked eye and protrudes from the mouth. endotracheal intubation tube, which can exert high pressure on the tongue for a long time, may cause te. this study was aimed to detect te, which may develop due to long-term pressure application of the intubation tube to the tongue, in patients hospitalized in the intensive care unit (icu) who underwent endotracheal intubation by submental ultrasonography (usg) method.

Eligibility criteria:
inclusion criteria: patients aged between 18-65 years patients who underwent endotracheal intubation and were admitted to the intensive care unit on the 0th day of intubation and patients who underwent endotracheal intubation during follow-up in the intensive care unit and were followed up on a mechanical ventilator - exclusion criteria: patients under the age of 18 and over the age of 65 patients who had a history of maxillofacial trauma, tongue surgery, head and neck malignancy, radiotherapy to the head and neck region, congenital anomalies of the tongue base and floor of the mouth patients who were admitted to the intensive care unit due to allergy-anaphylaxis -

Keywords: ultrasonography endotracheal intubation tube complication drugs tongue edema
ab interno gelatin stent with mitomycin c using targeted supra-tenon's placement

Conditions: Glaucoma

Summary: the xen-45 gelatin microstent is a novel, bleb-forming microinvasive glaucoma surgery (migs). despite demonstrating similar efficacy and safety to trabeculectomy (traditional surgery), the xen-45 gelatin microstent continues to suffer from occasional surgical failure due to fibrosis of the filtering bleb, and obstruction of the stent. during surgery, placement in a surgery known as supra-tenon's space is believed to maximize aqueous outflow, while preventing obstruction, limiting fibrosis of the bleb, and promoting long-term patency. despite the theoretical merits, long-term data of outcomes after targeted supra-tenon's placement is needed to fully assess its potential in improving xen-45 microstent outcomes.

the xen-45 gelatin microstent (allergan, dublin, ireland) is a novel, bleb-forming microinvasive glaucoma surgery (migs). creation of a filtering bleb through the gel stent and under the conjunctiva lowers intraocular pressure (iop) by bypassing the natural outflow pathway of aqueous. a recent retrospective cohort study showed comparable safety and risk of failure to trabeculectomy. amongst the main advantages of this device is the ability to create a bleb without dissecting and disrupting tissue, thus decreasing the amount of wound healing and potentially limiting bleb failure. however, despite demonstrating similar efficacy and safety to trabeculectomy,2 the xen-45 gelatin microstent continues to suffer from occasional surgical failure due to fibrosis of the filtering bleb, and obstruction of the stent. although antimetabolites, such as mitomycin c, have decreased reactionary wound healing that can result following surgery, fibrosis may still occur, especially when the components of the xen-45 gelatin microstent are in close proximity to the fibroblastic structures of tenon's fascia.tenon's capsule resembles a sponge-like layer with multiple adhesions to the overlying conjunctiva and underlying episclera. implantation of the xen within this space creates a higher risk of obstruction and subsequent failure. to ensure the lowest potential for occlusion, bleb scarring, and failure, one must ensure careful placement of the device in the subconjunctival space, avoiding intra-tenon's placement. placement in the supra-tenon's space is believed to maximize aqueous outflow, while preventing obstruction, limiting fibrosis of the bleb, and promoting long-term patency. despite the theoretical merits, long-term data of outcomes after targeted supra-tenon's placement is needed to fully assess its potential in improving xen-45 microstent outcomes.

Eligibility criteria:
inclusion criteria: * patients aged 30-90 with primary or pigmentary/pseudoexfolliative open angle, primary closed angle, or combined mechanism glaucoma with iop of 18-40 mmhg on maximum tolerated medical therapy who received a gelatin stent with mmc at prism eye institute from june 2012 to august 2019. exclusion criteria: * other forms of glaucoma * prior incisional glaucoma surgery * cpc * prior corneal graft (pkp, dalk, dsaek, dmek).
the effect of shotblocker on pain and satisfaction during measles-rubella-mumps vaccination

Conditions: Pain

Summary: objective the aim of this study was to evaluate the effects of shotblocker administration during measles-mumps-rubella (mmr) vaccination on infants' pain level and mothers' satisfaction. method. the study was conducted in a family health center affiliated to the public health directorate of a province in eastern turkey between august and october 2024 using a randomized controlled experimental design. the study sample consisted of 60 infants who received mmr vaccination (shotblocker group: n = 30, control group: n = 30). infants in the shotblocker group received shotblocker before vaccine injection, while infants in the control group received only routine vaccine injection. infant information form, flacc pain scale and newcastle satisfaction with nursing care scale were used for data collection. ethical principles were followed throughout the study.


Eligibility criteria:
inclusion criteria: * he's 12 months old, * mmr vaccine will be administered, * growth-development is normal, * no analgesic medication was given during the day, * at least high school graduate * mothers who volunteered to participate in the study exclusion criteria: * neurological disease, * a chronic disease, * allergy (egg allergy) * infants with symptoms of hyperthermia
construction of a prediction model for metachronous colorectal adenoma

Conditions: Metachronous Colorectal Adenoma

Summary: the study aimed to explore the independent risk factors for the metachronous colorectal adenoma after endoscopic resection, and construct the prediction model of metachronous colorectal adenoma, in order to provide theoretical basis for postoperative follow-up time of patients, and allocate limited medical resources.

a large cohort of eligible patients were included in the analysis, and classified into derivation and validation cohorts at a ratio of 7:3. demographic and clinicopathological characteristics of participants were utilized to develop a prediction model for metachronous colorectal adenoma. in the derivation cohort, the lasso regression method was applied to filter variables and multivariate logistic regression analysis was used to identify important predictors.a prediction model was established based on the results of multivariate logistic regression analysis. the predictive performance of the model was evaluated with respect to its discrimination, calibration and clinical usefulness.

Eligibility criteria:
inclusion criteria: * patients aged ≥18 and ≤75 years old. patients with complete data on demography and clinicopathology. exclusion criteria: * patients with a history of inflammatory bowel disease, enterophthisis, familial adenomatous polyposis, p-j syndrome and intestinal lymphoma. patients with a previous history of colorectal neoplasm. patients with a history of severe systemic diseases. lack of complete clinical data for analysis.
effect of metallic nanoparticles on nosocomial bacteria

Conditions: Nosocomial Infections

Summary: this research aims to study the properties of metallic nanoparticles"mnps" (silver nanoparticles "agnps" and copper nanoparticles "cunps") on the 2 most common nosocomial bacteria which are highly resistant to antibiotics including staphylococcus aureus and pseudomonas aeruginosa, to evaluate the growth inhibiting properties of mnps on all bacterial isolates, to evaluate the biofilm inhibitory effect on biofilm forming bacterial isolates and the synergistic effect of these mnps in combination with antibiotics on the antibiotic resistant isolates.

there is a rapid increase in the number of health care associated infections (hais) due to multi-drug resistant (mdr) bacterial strains which have a worse prognosis being associated with significant morbidity and mortality, particularly in critically ill patients. the main problem with mdr strains is their limited treatment options, posing a major challenge for health care providers.the increasing utilization and immense studies of nanoparticles have brought new perspectives towards new antimicrobial material that could hinder the mdr bacteria pandemic currently faced. particularly, metallic nanoparticles exhibit strong biocidal properties on different bacterial species, including mdr bacteria. another important aspect of the antimicrobial properties of metallic nanoparticles is their potential to eradicate or inhibit microbial biofilm formation, which is an important virulence factor in many localized chronic infections.

Eligibility criteria:
inclusion criteria: * urinary tract infections (uti) * surgical site infections (ssi) * catheter related blood stream infection (crbsi) * infected burns * chest infection exclusion criteria: * patients less than 18 years. * community acquired infections

Keywords: staphylococcus aureus pseudomonas silver nanoparticles copper nanoparticles
a study of a novel precision medicine approach for obesity

Conditions: Obesity

Summary: this study is being done to assess the efficacy of a saliva- based biomarker to predict response to semaglutide for the treatment of obesity.

the purpose of this study is to test the effectiveness of semaglutide 2.4 mg sq weekly in patients with obesity with a positive myphenome test for abnormal postprandial satiety compared to patients with obesity with a negative myphenome test for abnormal postprandial satiety.

Eligibility criteria:
inclusion criteria: - obesity (bmi ≥30 kg/m2) without or with controlled chronic conditions (e.g., controlled hypertension). exclusion criteria: * weight changes greater than 3% in the previous 3 months * history of bariatric surgery including lap band and bariatric endoscopy * significant untreated psychiatric dysfunction based upon screening with the hospital anxiety and depression inventory (had), questionnaire on eating and weight patterns (binge eating disorders and bulimia) and columbia suicide severity rating scale (c-ssrs). if such a dysfunction is identified by an anxiety or depression score \>11 or difficulties with substance or eating disorders, the participant will be excluded and given a referral letter to his/her primary care doctor for further appraisal and follow-up. any suicidal ideation of type 4 or 5, any suicide attempt during the patient's lifetime, or any suicidal behavior in the last month. * current use of anti-obesity medications or glp1r agonists for type 2 diabetes * any contraindication to fda-approved glp1r agonists * a person who is pregnant or wanting to become pregnant * once the positive or negative cohort is filled at 2:1 ratio, some patients will be screen failed if their gene cohort is full. * a family member who is enrolled in this study. * principal investigator discretion
knee genicular nerve ablation by thermal radiofrequency vs thermal radiofrequency plus alcohol neurolysis

Conditions: Knee Osteoarthritis

Summary: the aim of our study is to compare effectiveness (satisfaction) and duration of pain relief between patients receiving the conventional thermal radiofrequency on the genicular nerves alone vs patients who will receive the conventional method plus alcohol neurolysis of the targeted nerves.


Eligibility criteria:
inclusion criteria: 1. both genders. 2. age between 60-70 years. 3. asa 1,2 \& 3 physical status. 4. x ray imaging confirming the osteoarthritis and unwell or not candidate for knee replacement surgery exclusion criteria: 1. neurological disorders.(previous cerebrovascular stroke , neuropathy , or weakness ) 2. coagulopathy ( plt \ 1.7 ) 3. infection at or near the injection site. 4. presence of pacemaker or defibrillator 5 - acute knee injury. 6- age \ 70 years