Kornimate/medical-research-clean huggingface dataset:
effects of dexmedetomidine on patients with coronary heart disease after percutaneous coronary intervention

Conditions: Heart Injuries

Summary: coronary heart disease has a high incidence and high death rate. percutaneous coronary intervention (pci) is an important method for the treatment of coronary heart disease (chd). however, pci may cause myocardial cell injury and myocardial infarction 4 type(mi4a, type 4 a myocardial infarction related to pci). dexmedetomidine(dex) is the only anesthetic which has sedative and analgesic effects. dex currently has been widely used in perioperative management of various surgical.this study intends to verify the effect of heart protection of dex in perioperative.

participants will be randomly assigned, in a 1:1 ratio, to receive dexmedetomidine or control (0.9 %sodium chloride solution,0.9%nacl). the randomization sequence will be computer-generated, and randomization will be performed in blocks and will be stratified according to participating center. dexmedetomidine and 0.9 % nacl solution will be transfused when the operation began, ending 24 hours after the surgery. troponin i level(but are not limited to these data) at pre-operation and 3h, 6h,12h, 24h, 48h after pci will be recorded. at the same time, other dates will be recorded.the participation of each patient is scheduled for 12 months.

Eligibility criteria:
inclusion criteria: * the patients were coincided to chd combined with depression and anxiety according to diagnostic standard of world health organization(who)who need receive selective pci in the first affiliated hospital of xi'an jiaotong university; * people aged over 18; * patients who will undergo pci with hamilton anxiety scale of 14 points or more. exclusion criteria: * severe comorbidity history; * coronary stenosis less than 70%; * severe cardiac dysfunction; * central nervous system disease; * troponin i levels have rised before entering the hospital; * pregnant woman； * history of mental disorders; * alcoholic and long-term use of sedatives and opioids history; * drug allergy history.
exercise effects on the neurobiology underlying stress-related eating behaviors in veterans

Conditions: Overweight/Obesity; Stress

Summary: the purpose of this study is to learn more about how common lifestyle interventions, such as exercise, affect how our brains respond to performing thinking tasks and to viewing pictures of foods and various other objects. the investigators are also interested in how changes in hormones that might be different in men and women could affect how lifestyle interventions change these brain responses.

the purpose of this study is to learn more about how common lifestyle interventions, such as exercise, affect how our brains respond to performing thinking tasks and to viewing pictures of foods and various other objects. the investigators are also interested in how changes in hormones that might be different in men and women could affect how lifestyle interventions change these brain responses. this will help us to better understand how different lifestyle interventions affect the brain and how this might relate to various behaviors. eligible participants will be asked to complete 2 study days before and again after a 12-week intervention period, during which they will either continue with usual activities or be asked to complete exercise sessions four times per week. they will be randomly assigned to one of these conditions (exercise or not) and will not be able to choose their group assignment.

Eligibility criteria:
inclusion criteria: * veterans 18-75 years old * bmi of 25 or greater * physically inactive * able to attend study visits in person in aurora, co exclusion criteria: * currently pregnant * history of bariatric surgery * contraindication to mri (weight \> 500 lbs; claustrophobia; metal or electronic devices in the body) * unable to exercise due to cardiac, pulmonary, neurologic, or orthopedic reasons * unable to pass screening graded exercise treadmill test

Keywords: overweight obesity stress eating
the effect of circadian rhythms on norctrend index in anesthesia

Conditions: Patients Needed Surgery and Anesthesia; Except on the Head or Facial Surgery

Summary: the purpose of this study is to determine whether the circadian rhythms effects on the norctrend index in anesthesia.

it has been reported that circadian rhythm has many aspects of influence on human body. but little is knew about the circadian rhythm affect on narcotrend index (made in germany) in total intravenous anesthesia .the investigators' study is to find the relationship between them.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists（asa） ⅰ - ⅱ; * ability to compliance the research plan; * volunteered and signed for the study ; * receive surgery and general anesthesia exclusion criteria: * asa\>ⅱ; * head or facial surgery * can't collaborate;
effect of elemental diet on adult patients with eosinophilic gastroenteritis

Conditions: Eosinophilic Gastroenteritis

Summary: the purpose of this study is to investigate the effect of an elemental diet on adult patients with eosinophilic gastroenteritis

this prospective interventional study will investigate the effect of an exclusive, six week elemental diet in adult patients with eosinophilic gastroenteritis

Eligibility criteria:
inclusion criteria: 1. participant must be able to understand and provide informed consent 2. males and females ≥18 to 65 years of age; 3. have diagnosis of eg/ege 4. have histologically confirmed active disease \> 30 eosinophils/hpf 5. symptomatic (have experienced symptoms within the last one months prior to enrollment). 6. female subjects of childbearing potential must have a negative pregnancy test upon study entry 7. female (and male) subjects with reproductive potential, must agree to use fda approved methods of birth control for the duration of the study-specific methods may be listed, if applicable exclusion criteria: 1. inability or unwillingness of a participant to give written informed consent or comply with study protocol 2. secondary causes of gastrointestinal and peripheral eosinophilia 3. eosinophilic infiltration isolated to the esophagus. 4. pregnancy 5. immunodeficiency states 6. have been treated with topical swallowed steroids within the last 6 weeks or systemic steroids within the last 2 months unless repeat endoscopy is performed and shows active inflammation on these therapies in which case these medications will be allowed to be continued without dose escalation. 7. have taken immunosuppression medication or immunomodulators within 2 months of the study unless the recent/baseline endoscopy has active histologic inflammation while on these medications. in this case, these medications will be permitted to be continued as long as the dose is not escalated during the treatment phase. 8. have been on an elemental diet previously for six weeks with follow up endoscopy completed. 9. have participated in any investigative drug study within 6 weeks prior to study entry. 10. unable to complete study procedures including endoscopy. 11. past or current medical problems or findings from physical examination or laboratory testing that are not listed above, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.
efficacy of prophylactic epinephrine solution injection in prevention of delayed post-sphincterotomy

Conditions: Bleeding Hemorrhage

Summary: bleeding is the most frequently reported serious complication of endoscopic sphincterotomy, and severe bleeding has occurred in about 1% to 2% of patients. endoscopic injection of epinephrine is the most commonly used, effective, and least expensive method for the management of post- sphincterotomy bleeding. however, the efficacy of prophylactic saline-epinephrine solution injection to prevent delayed est bleeding when transient bleeding during ercp has not been established.

backgroud: bleeding is the most frequently reported serious complication of endoscopic sphincterotomy, and severe bleeding has occurred in about 1% to 2% of patients. endoscopic injection of epinephrine is the most commonly used, effective, and least expensive method for the management of post- sphincterotomy bleeding. however, the efficacy of prophylactic saline-epinephrine solution injection to prevent delayed est bleeding when transient bleeding during ercp has not been established. study rationale: the hypotheses of the study is the prophylactic saline-epinephrine solution injection affects incidence of delayed post-est bleeding. study design: a single blinded parallel group, multiple center, randomized controlled trial. the sample size is estimated 400 (200 in injection group and 200 in non-injection group), the primary outcome is the rate of delayed est bleeding within 30 days of ercp. study objectives: primary objective: the rate of post-est bleeding within 30 days of ercp secondary objectives: the rate of post-ercp advese effect, the increasing procedure time because of hemostasis, the need for angiographic/endoscopic hemostasis times.

Eligibility criteria:
inclusion criteria: * age 20 years or older. * ability to give informed consent. * an naive major papilla. * transient bleeding after endoscopic sphincterotomy * bleeding less than 30 secs when end of procedure exclusion criteria: * prior endoscopic sphincterotomy. * thrombocytopenia (platelets \<50,000/mm3). * liver cirrhosis (child a-c) * ckd stage 4-5 and dialysis. * allergy to epinephrine * prolonged pt/aptt (inr\>1.5) * had exposure any antithrombotic or antiplatelet agent in recent 7 days and/or will take those agents in one month after est * ampulla vater tumor * active gi bleeding * pregnancy * limited visibility when immediate bleeding after sphincterotomy * still bleeding after 30 secs when end of procedure * recurrent bleeding during ercp

Keywords: sphincterotomy epinephrine solution
efficacy and safety of lanreotide autogel in tumour stabilization of patients with progressive neuroendocrine tumours

Conditions: Neuroendocrine Tumours

Summary: to evaluate, in patients with progressive neuroendocrine tumours who are not eligible to be treated with either surgery or chemotherapy at the moment of study inclusion, the efficacy of lanreotide autogel in tumour growth stabilization.


Eligibility criteria:
inclusion criteria: * patients with histopathologic diagnosis of well-differentiated neuroendocrine tumour or carcinoma according to who classification * patients who, according to recist criteria (response evaluation criteria in solid tumours) present measurable disease * patients with progressive disease in the previous 6 months before their inclusion in the study * patients with positive in111 octreotide scintigraphy exclusion criteria: * patients with surgically removable localised disease * patients with progressive disease in the first six months of being diagnosed * patients with intestinal obstruction due to a carcinoid tumour * patients who have received treatment with somatostatin analogues during the 6 months before being included in the study * patients who have received treatment with radiotherapy, chemotherapy or interferon 4 weeks before being included in the study, or planned to receive these during the study * patients who have received treatment with liver artery embolisation or radiopharmaceuticals (endoradiotherapy) 12 weeks before being included in the study, or planned during the study.
effectiveness of topical glycerine sulphate paste, hirudoid cream and nil application on superficial phlebitis

Conditions: Infection

Summary: the aim of the interventional study is to compare the different treatment modalities in reducing erythema size and rate of resolving phlebitis.


Eligibility criteria:
inclusion criteria: * patients admitted to the study institution between dec 2009 and feb 2010 and observed to develop redness associated with peripheral infusion cannula. exclusion criteria: * thrombosis, poor skin condition, and pus seen at the previous puncture.

Keywords: superficial phlebitis cannula-related vein inflammation glycerine magnesium sulphate hirudoid cream nursing
electronic algorithms based on host biomarkers to manage febrile children

Conditions: Acute Febrile Illness

Summary: health professionals in developing countries have limited ability to identify children at risk of dying and those in need of antibiotics. the main reasons are limited clinical skills and time, unavailability of diagnostic tests (laboratory or x-ray) and non-adherence to practice guidelines. child mortality is therefore higher than it should be. etiological diagnostic tests (detecting microorganisms) may not always help since the distinction between infection and disease and between mild or severe disease is not straightforward. overprescription of antibiotics is therefore widespread and leads to the development of drug resistance. to address these challenges, decision charts for the management of febrile illness will be developed and include i) few clinical parameters simple to assess, and ii) pocts results based on specific host markers that can discriminate between mild and severe disease, pneumonia and upper respiratory tract infections, and unspecific fevers of bacterial and of viral origin. this algorithm combining clinical and bedside laboratory tests will be built on an electronic support (android tablet). the first objective of the study is to assess the safety of new electronic decision trees that integrate simple clinical assessment and pocts results (oxygen saturation and a combination of specific biomarkers of inflammation) as a triage tool to decide on admitting febrile children; the second objective is to assess the usefulness and safety of new electronic decision trees that integrate simple clinical assessment and poct results (a combination of specific biomarkers of inflammation) as decision-making tool to prescribe antibiotics to non-severe febrile children. the development of such a tool will decrease mortality due to delayed admission, at the same time, it will decrease irrational use of antibiotics, and hence drug pressure and emergence of drug resistance, which represents one of the most important public health threat our world is facing today. this project has the potential of huge applicability since it is specifically designed for end-users with limited medical skills and low resources, as it is the case in most areas of developing countries.


Eligibility criteria:
inclusion criteria: * age ≥2 months and \<60 months of age * written informed consent from the child's parent or caregiver * axillary temperature ≥37.5°c and/or tympanic temperature ≥38.0°c * history of fever for ≤7 days * first consultation for the current illness * live in the catchment area of the health facility exclusion criteria: * age 60 months or greater * age less than 2 months * weight less than 2.5kg * chief health problem is an injury, trauma or acute poisoning

Keywords: fever point-of-care tests clinical algorithms electronic support host biomarkers
a 8-month study on the use of intra-oral camera and text messages on gingivitis control

Conditions: Behavior and Behavior Mechanisms; Gingivitis

Summary: to investigate the effects of using an intra-oral camera (ioc) during supportive periodontal therapy, and oral hygiene mobile text messages (sms) between appointments on clinical, behavioral and psychological parameters of patients with gingivitis.

dental hygiene behaviours are of paramount importance for controlling gingival health. there is evidence on the use of ioc and of text messages in boosting motivation, sustainability and clinical efficacy of dental hygiene behaviors. orchestrating these two technologies is expected to create a coaction effect which could improve behavior change interventions, but the effectiveness of such strategy needs to be inspected.

Eligibility criteria:
inclusion criteria: gingivitis bomp \> 0.5 20 teeth (minimum 5 per quadrant) \> 18 years old exclusion criteria: periodontitis (pockets \>3), smoking, orthodontics, pregnancy removable partial dentures

Keywords: gingivitis sms text messages behavior change hapa dental hygiene
mixed nuts and brain vascular function

Conditions: Brain Vascular Function; Cerebral Blood Flow

Summary: impaired brain vascular function precedes the development of reduced cognitive performance, while brain insulin-resistance is also associated with cognitive decline. the mediterranean diet, which is rich in nuts, may protect against the development of impaired cognitive performance. the hypothesis is that long-term mixed nut consumption increases brain insulin-sensitivity thereby improving brain vascular function and cognitive performance. the primary objective is to evaluate in elderly men and women the effect of 16-week mixed nut consumption on cerebral blood flow, as quantified by the non-invasive gold standard magnetic resonance imaging (mri)-perfusion method arterial spin labelling (asl). cerebral blood flow is a robust and sensitive physiological marker of brain vascular function. secondary objectives are to investigate effects on the cerebral blood flow response to intranasal insulin delivery - a marker of insulin-sensitivity in the human brain - as quantified by asl, and cognitive functioning as assessed with a neuropsychological test battery.


Eligibility criteria:
inclusion criteria: * aged between 60-70 years * bmi between 25-35 kg/m2 * fasting plasma glucose \< 7.0 mmol/l * fasting serum total cholesterol \< 8.0 mmol/l * fasting serum triacylglycerol \< 4.5 mmol/l * systolic blood pressure \< 160 mmhg and diastolic blood pressure \< 100 mmhg * stable body weight (weight gain or loss \< 3 kg in the past three months) * willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study * no difficult venipuncture as evidenced during the screening visit exclusion criteria: * allergy or intolerance to nuts * left-handedness * current smoker, or smoking cessation \< 12 months * diabetic patients * familial hypercholesterolemia * abuse of drugs * more than 3 alcoholic consumptions per day * use of products or dietary supplements known to interfere with the main outcomes as judged by the principal investigators * use medication to treat blood pressure, lipid or glucose metabolism * use of an investigational product within another biomedical intervention trial within the previous 1-month * severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and rheumatoid arthritis * active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident * contra-indications for mri imaging (e.g. pacemaker, surgical clips/material in body, metal splinter in eye, claustrophobia)

Keywords: brain insulin sensitivity cognitive performance
intraductal meibomian gland probing trial

Conditions: Meibomian Gland Dysfunction

Summary: in this research study, the investigators are looking at the effects of meibomian gland probing (mgp) versus a sham (fake) procedure in patients with refractory mgd who have already tried traditional management with no success in resolving their clinical signs (as seen by their ophthalmologist) or their symptoms. the investigators are also evaluating the effects of using two (2) post-procedural medication treatments: blephamide or genteal pm night-time to determine if treatment after the mgp procedure has an effect on its outcome.

dry eye disease is one of the most common conditions seen in ophthalmic practice and is associated with significant patient distress. meibomian gland dysfunction (mgd) is among the most prevalent causes of dry eye disease. this condition, which is often due to obstruction of the meibomian gland orifices, may result in significant ocular irritation. traditionally, management of mgd includes warm compress, lid hygiene, and anti-inflammatory medications. this randomized clinical trial is designed to evaluate the effects of meibomian gland probing versus sham procedure in cases with refractory mgd that do not respond to traditional treatments. moreover, the effects of postoperative regimen will also be investigated using two different regimens. in addition to symptoms, the changes will also be evaluated in terms of clinical signs as well as in vivo confocal microscopy (ivcm) which allows study at the cellular level.

Eligibility criteria:
inclusion criteria: * age 18-89 years * willing and able to provide written informed consent * willing and able to comply with study assessments for the full duration of the study * diagnosis of meibomian gland dysfunction (mgd) * symptoms of mgd such as foreign body sensation, burning, stinging, light sensitivity for at least 3 months * persistent symptoms despite at least 3 months of medical management including lid hygiene, warm compress, and use of topical and systemic therapy, or contraindication to systemic therapy * presence of lid tenderness on the upper lids in both eyes * tear break-up time (tbut) of \<10 seconds * in good stable overall health exclusion criteria: * active allergies to steroids, sulfacetamide, genteal pm night-time ointment, or lidocaine * intraocular surgery or ocular laser surgery within 1 month before enrollment * history of ocular infection within 1 month before enrollment. * history of increased intraocular pressure after using topical steroids (steroid responsive) * any condition (including language barrier) that precludes subject's ability to comply with study requirements including completion of study
analysis of radiographic and kinematic features in fai patients

Conditions: Femoro Acetabular Impingement

Summary: the goal of this observational study is to describe the radiographic and kinematic features in patients with femoroacetabular impingement syndrome (fai). the main questions it aims to answer are: * is structural knee abnormalities associated with knee pain symptoms in fai patients? * does fai patients with knee pain demonstrate unique kinematic characteristics？ participants will receive routine preoperative radiographic examinations, which include ipsilateral knee mri for the purpose of femoral version measurement. participants will also receive markerless motion capture analysis. researchers will compare preoperative radiographic and kinematic features based on knee pain status, which is routinely collected as part of clinical investigation procedures.

this observational study aims to study the association between preoperative subjective knee pain and baseline knee radiographic and kinematic characteristics. mri of the ipsilateral knee is screened for structural abnormalities, including cartilage defects, meniscal tears and ligament injuries. markerless motion capture data are evaluated for transverse plane kinematic features, with a primary focus on foot progression angles during normal gait.

Eligibility criteria:
inclusion criteria: * (1) diagnosed with fai based on clinical and radiographical findings; * (2) failed conservative treatment for at least 6 months and indicated for surgical treatment; * (3) received routine preoperative hip and ipsilateral knee mri. exclusion criteria: * (1) history of fracture or surgery of hip and knee; * (2) avascular necrosis; * (3) legg-calve-perthes disease; * (4) ehlers-danlos syndrome; * (5) pigmented villonodular synovitis (pvns); * (6) osteoid osteoma (oo); * (7) synovial chondromatosis; * (8) severe hip osteoarthritis (oa) with tönnis grade \> 1; * (9) developmental dysplasia of hip (ddh)