Kornimate/medical-research-clean huggingface dataset:
case management study to reduce health care utilization for frequent hospital care users

Conditions: Quality of Life

Summary: the purpose of this study is to identify persons with high risk of frequent hospital admissions and by counselling by one in depth interview followed by frequent telephone contacts improve their quality of life and reduce their healthcare utilization.

participants are identified by administrative data and a model predicting high risk of future healthcare utilization. participants are invited to the study by mail. after informed consent participants are randomized to either active treatment or control 3:1. active patients have an in depth interview with a specially trained nurse. further counselling by telephone weekly for 6-9 months. quality of life is measured by sf-36 every 3 months for one year both in active participants and in controls.

Eligibility criteria:
inclusion criteria: * patient \> 18 years * recent history of contact with hospital * anticipated sustained high visit frequency exclusion criteria: * dementia (icd10: f00-f03 or f051) * psychoses (icd10: f20-f29) * drug abuse (icd10: f10-f19) * metastases (icd10: c77-c80) * hearing impairment or language difficulties * life expectancy \< 1 year no telephone

Keywords: quality of life health care utilization
slow-release tb4 collagen and chitosan porous sponge scaffolds skin substitute treatment is difficult to heal wounds

Conditions: Wounds

Summary: evaluation of slow-release tb4 collagen and chitosan porous sponge scaffolds skin substitutes the effectiveness of clinical trials for the treatment of difficult to heal wounds and security.


Eligibility criteria:
inclusion criteria: 1. meet difficult had 1 month or more to heal the wound patients 2. who signed the informed consent of men or women older than 17 (pregnancy) 3. has the ability to care for, has the ability to self signed informed consent, 7 to 17 years old must be signed by the guardian informed consent 4. the process of mental stability, can finish the test exclusion criteria: 1. known allergic to bovine collagen or gao min physique 2. the wound is greater than the10cm×10cm 3. people with mental illness, drug abusers and or other items 4. pregnant women,prepare a pregnancy or breast feeding women 5.3 months participated in other similar experiment 6.serious infectious disease not controller 7.with surgery, such as severe trauma stress situation 8.can not meet the requirement of the long-term follow-up of patients

Keywords: tb4 difficult to heal
effect of phonophoresis on trigger points

Conditions: Trigger Point Pain, Myofascial

Summary: purpose of this study was to investigate the effects of phonophoresis with fastum gel versus reparil gel on pain intensity, pain threshold, and cervical rom of participant with trigger point of upper trapezius.

participants will be divided into 3 groups, 2 study groups and 1 control group.

Eligibility criteria:
inclusion criteria: * upper trapezius trigger point exclusion criteria: * cervical disc
perspective analysis of coronal imbalance in degenerative scoliosis

Conditions: Scoliosis

Summary: currently there is paucity of information on the prevalence of pre-operative coronal imbalance in patients with degenerative lumbar scoliosis (dls) and its influence on surgical outcomes. this study aims to investigate in dls, the prevalence of coronal imbalance, to propose a novel classification system and to investigate whether pre-operative coronal imbalance affects clinical outcomes following osteotomy. a total of 284 dls patients were recruited.

a total of 284 dls patients were recruited into this two-stage study, among which 69 patients were treated by posterior-only correction and the remaining 215 patients received conservative treatment. using pre-operative long-cassette x-ray films, all patients were classified based on coronal balance distance (cbd) defined as the horizontal distance between c7 plumb line and central sacral vertical line: type a, cbd \ 3cm and c7pl shifts to the concave side of curve; type c, cbd \> 3cm and c7pl shifts to the convex side of curve. the prevalence of pre-operative coronal imbalance was calculated for stage i study. post-operative cbd in patients who received surgery was measured to evaluate clinical outcomes for stage ii study.

Eligibility criteria:
inclusion criteria: age \> 50 years, diagnosis of dls based on radiographies and previous medical history and cobb angle \>25°. exclusion criteria: -
mainz register of patients with sleep disorders

Conditions: Sleep Disorder; Sleep Disorder Parasomnia; Narcolepsy; Sleep Apnea; Insomnia; Somnambulism; Idiopathic Hypersomnia; Restless Legs Syndrome; REM Behavior Disorder

Summary: prospective longitudinal observational registry study of all patients with sleep disorders treated in the mainz comprehensive epilepsy and sleep medicine center with the focus on the course of the disease and quality of life.

clinical parameters of patients, such as onset of the disease, prior medication, disease severity, which are important for the data analysis also collected retrospectively before the initiation of the registry. data on the quality of life is collected only prospectively

Eligibility criteria:
inclusion criteria: * patients with narcolepsy * patients with other neurological sleep disorders exclusion criteria: * patients aged \<18 years * patients who cannot provide informed consent and don't have a legal guardian
simple cognitive task after trauma ekut rct

Conditions: Post Traumatic Stress Disorder

Summary: this research study is designed to investigate the effects of a simple cognitive task (a memory cue following by playing the computer game "tetris") on intrusive memories ("flashbacks") and other symptoms after a traumatic event. patients presenting to a hospital emergency department soon after a traumatic event will be randomly allocated to either the simple cognitive task intervention or control. participants will be followed up at one week and one month, and where possible 3 and 6 months. it is predicted that participants given the simple cognitive task intervention will develop fewer intrusive memories and less severe related clinical symptoms than those who are not. this will inform the future development of a simple technique to prevent distressing psychological symptoms after a traumatic event. implementation and training aspects in a hospital context will also be explored. patients use their smartphone for part of the intervention in the study.

this is a randomised controlled trial informed by prior feasibility and pilot work (clinicaltrials.gov id: nct03509792). the primary outcome is the number of intrusive memories of the traumatic event (week 5). the intervention is delivered in emergency departments of swedish hospitals.

Eligibility criteria:
inclusion criteria: * aged 18 or over * experienced or witnessed a traumatic event resulting in admission to the emergency department * met the diagnostic and statistical manual of mental disorders, 5th edition (dsm5) criterion a for posttraumatic stress disorder (ptsd) in that ("the person was exposed to actual or threatened death, serious injury, or sexual violence" by "directly experiencing the traumatic event(s)" or "witnessing, in person, the event(s) as it occurred to others") * can be seen in the emergency department ca. 6 hours after the traumatic event (day 1) * report memory of the accident * fluent in spoken and written swedish * alert and orientated * have sufficient physical mobility to use their smartphone * willing and able to provide informed consent and complete study procedures * willing and able to be contacted following discharge to complete follow-up assessments * have access to an internet enabled smartphone exclusion criteria: * loss of consciousness of \> 5 minutes * current intoxication * report a history of severe mental illness * current substance abuse or neurological condition * currently suicidal * other medical reasons (on advice by medical staff)
real-life clinical outcomes of direct oral anticoagulants (macacod)

Conditions: Atrial Fibrillation; Recurrent Venous Thromboembolism

Summary: macacod is a clinical record in the usual clinical practice of direct oral anticoagulants (dabigatran, rivaroxaban, apixaban and edoxaban). design: single-center, observational, prospective, uncontrolled study of anticoagulated patients with any direct oral anticoagulant (doac) with atrial fibrillation or venous thromboembolism to determine the incidence of serious complications (thromboembolic or hemorrhagic) in real life

population: patients over 18 years of age, with recurrent atrial fibrillation or venous thromboembolism, already anticoagulated with any doac or patients who initiate therapy with doac and who give their consent. upon entering the study, demographic data, previous anticoagulant treatments, previous serious complications, comorbidities and baseline analytical results are recorded. the risk scores cha2ds2-vasc, has-bled and charlson comorbidity index (cci) are calculated. the type of health education received in relation to anticoagulant therapy is also recorded. during the follow-up, complications and clinical changes and the analytical results of coagulation, renal and hepatic function will be recorded. the risk scores will be updated at each visit. in case of serious complications, the associated costs will be estimated.

Eligibility criteria:
inclusion criteria: · patients older than 18 years. * with atrial fibrillation or recurrent venous thrombosis. * in chronic treatment with any doac type drug. * patients who sign the informed consent exclusion criteria: * patients who do not guarantee collaboration. * patients with advanced cognitive impairment and not supervised. * patients with alcoholism. * patients with psychiatric disorder and not supervised

Keywords: dabigatran rivaroxaban apixaban edoxaban
kinesio-taping in stroke patients with visuospatial neglect

Conditions: Stroke; Motor Disorder

Summary: stroke is the second leading cause of death worldwide and the third most common cause of disability. the effects of stroke are variable and may include impairments in motor and sensory systems, emotion and neuropsychological deficits such as a disorder of spatial awareness known as unilateral spatial neglect (usn). approaches to ameliorate usn could be categorized in interventions as involving either bottom-up or top-down processing. the specific mechanisms underlying these effects on a number of manifestations of the usn syndrome may include the restoration of defective representations of the side of space contralateral to the lesion (contralesional), and of the ability to orient spatial attention contralesionally, through complex patterns of activation of both the damaged right hemisphere, and the contralateral left hemisphere, with differences related to the specific stimulation delivered to the patient. in recent years, increasing cutaneous stimuli through neuromuscular kinesiotaping has been proposed to enhance somatosensory inputs (24) and such as method could have positive effects on usn. the aim of the present study was to assess the effect of ktm applied on the sternocleidomastoid muscle controlateral side of the lesions in improving usn deficits in individuals with stroke patient in sub-acute phase. the hypothesis is that the ktm application could improved cognitive tests for assessing usn, motor deficits and kinesthetic neck sensibility.


Eligibility criteria:
inclusion criteria: * patients affected by stroke from cerebral ischemia or hemorrhage that occurred ⩽ 30 days before; * presence of visuospatial neglect (star cancellation test' score \< 50) * able to actively rotate the head toward left side in closed eyes condition. exclusion criteria: * the presence of dementia (mini-mental state examination correct score lower than 23,80) * severe deficit of comprehension * psychiatric disorders * hemianopsia patients (diagnosed with perimetry) patients or their family members did not consent to this study.

Keywords: neglect, stroke, rehabilitation, range of motion
immunotherapy of cervical cancer with v3-cervix

Conditions: Cervical Cancer

Summary: the goal of this trial is to evaluate the efficacy of immunotherapy for cervical cancer based on a fundamentally new approach. we will test new tableted preparation, v3-cervix, obtained from hydrolyzed, inactivated blood and tumors of patients with cervical cancer. when administered orally, it should cause a specific anti-tumor immune response and an anti-inflammatory effect. trial is planned to last 3 months, recruit 20 volunteers, administer daily pill of vaccine and evaluate effect on tumor size and tumor markers.

cervical cancer (cc) is a malignant neoplasm that occurs in the cervix. histologically, there are two main types: adenocarcinoma and squamous cell carcinoma. cervical cancer is most common in middle-aged women (35-55 years of age), in 20% of cases it is found over the age of 65 years. cancer of the body and cervix are the most common type of malignant tumor of female genital organs. it is believed that human papillomavirus (hpv) is the main risk factor causing cervical cancer. cervical cancer combines surgical treatment, radiotherapy and chemotherapy. current immunotherapies did not show much success. the prognosis depends on the stage of the disease: 5-year survival rate at the first stage is 78.1%, at the second stage - 57%, at the third - 31%, at the fourth - 7.8%. there is no specific cervical cancer marker, usually a panel of markers is used including ca125, beta-hcg, cea, scc, ca19.9 and ca27.29. the goal of this trial is to evaluate the efficacy of immunotherapy for cervical cancer based on a fundamentally new approach. we will test new tableted preparation, v3-cervix, obtained from hydrolyzed, inactivated blood and tumors of patients with cervical cancer. when administered orally, it should cause a specific anti-tumor immune response and an anti-inflammatory effect. trial is planned to last 3 months, recruit 20 volunteers, administer daily pill of vaccine and evaluate effect on tumor size and tumor markers.

Eligibility criteria:
inclusion criteria: confirmed diagnosis of cervical cancer available baseline measurement of tumor size and burden presence of tumor markers associated with cervical cancer, i.e., ca125, beta-hcg, cea, scc, са19.9 and са27.29 - exclusion criteria: metastases to other sites hysterectomy -

Keywords: cervix uterus
the effect of breathing exercise on sleep and stress levels in women with breast cancer receiving chemotherapy treatment

Conditions: Women Receiving Chemotherapy; Poor Quality Sleep; Breast Cancer Stage II

Summary: women receiving chemotherapy have poor sleep quality and high stress levels. with a method such as breathing exercise, which can be applied at any time without side effects, positive improvements in women's sleep and stress levels can be recorded.

women receiving chemotherapy have poor sleep quality and high stress levels. with a method such as breathing exercise, which can be applied at any time without side effects, positive improvements in women's sleep and stress levels can be recorded.

Eligibility criteria:
inclusion criteria: * women receiving chemotherapy women with poor sleep quality 18 years of age and above women with high stress levels exclusion criteria: * who do not want to participate

Keywords: chemotherapy, sleep quality, breathing exercise
intraperitoneal aerosol chemotherapy in gastric cancer

Conditions: Gastric Cancer

Summary: a prospective series of patients with recurrent gastric cancer will be treated with three cycles of chemotherapy (doxorubicin and cisplatin) instilled into the abdominal cavity in the form of an aerosol under pressure via laparoscopy. the efficacy of this treatment will be assessed by computed tomography, tumor marker studies, and survival. also, the safety of the procedure will be assessed.

objectives: to evaluate the safety and efficacy in terms of the clinical benefit rate (cbr) of pipac in peritoneal carcinomatosis (pc) from gastric cancer (gc) study design: single center, open label, non-randomized, single-arm, repeated single dose study to explore the efficacy, safety, and cbr of doxorubicin and cisplatin when given as a pressurized intraperitoneal aerosol chemotherapy (pipac) to patients with advanced gastric cancer and peritoneal carcinomatosis. target subject population:patients with gc and pc with disease progression after at least one line of previous i.v. chemotherapy. investigational product, dosage and mode of administration doxorubicin 1.5 mg/m2 body surface in 50 ml nacl 0,9% and cisplatin 7.5 mg/m2 in 50 ml nacl 0,9% q 4-6 weeks, applied intraperitoneally as pipac. duration of treatment: 3 single doses in 6 weeks intervals, duration of treatment is 18 weeks outcome variables: 1.1 primary outcome variable • clinical benefit rate (cbr) according to response evaluation criteria in solid tumors (recist) criteria (version 1.1) after 3 cycles of pipac with cisplatin and doxorubicin. 1.2 secondary outcome variables * the observed survival (os) * the median time to progression (ttp) according to recist criteria after three cycles of pipac with cisplatin and doxorubicin * the peritoneal carcinomatosis index (pci) before and after therapy * the degree of histological regression assessed by pathological review * apoptosis as assessed by immunohistochemical analysis * the difference in ascites volume before and after the first, second, and third pipac application 1.3 patient reported outcomes (pros) * european organization for research and treatment of cancer (eortc) quality of life questionnaire (qlq-c30, german version ) 1.4 safety * safety and tolerability will be assessed by collection of adverse events, according to the common terminology criteria for adverse events (ctcae) including physical examination results, laboratory assessments (chemistry and hematology). 1.5 biological monitoring • basic research investigating expression of genes associated with drug resistance.

Eligibility criteria:
inclusion criteria: * age above 18 years * written, informed consent * presence of peritoneal carcinomatosis exclusion criteria: * language barrier * parenchymal metastases * unability to undergo laparoscopy

Keywords: gastric cancer chemotherapy intraperitoneal
influencing factors of cerebrovascular disease and cognition in hemodialysis patients

Conditions: Hemodialysis; Cognitive Impairment; Cerebrovascular Disorders

Summary: in this observational study, the investigators evaluate the influencing factors of cerebrovascular disease and cognition in hemodialysis patients.


Eligibility criteria:
inclusion criteria: 1. maintenance hemodialysis patients who are younger than 85 years old and older than 50 years old, regardless of gender 2. dialysis vintage is greater than 3 months; exclusion criteria: 1. those with severe infection and anemia (hb \<60g / l); 2. those with severe mental illness, metabolic diseases and immune system diseases; 3. patients with abnormal liver function
efficacy of art intervention on decreasing pain and anxiety during intravenous cannulation

Conditions: Catheterization; Pain; Anxiety; Art; Children

Summary: peripheral intravenous cannulation (pivc), one of the most common therapeutic procedures in medical care, can be difficult even for experienced medical practitioners. the pain of intravenous cannulation is considered the major limitation in pediatric clinical care. reducing the pain of intravenous cannulation has been the motive for many investigations. intervention methods used to reduce the distress related to painful procedures are widely recommended. the management of pain and anxiety is more essential because it may modify children's memory for procedural pain and the subsequent acceptance of later health care painful interventions. distraction is the most studied psychological technique to relieve venipuncture-related pain and distress, with strong evidence supporting its efficacy in children. art therapy commonly used to reduce pain and anxiety of children's disease but was not used in reducing distress outcomes of painful procedures. we used a collection of the image need for coloring and tracing called trace image and coloring for kids-book (tick-b). the purpose of this study is to exam the effectiveness of tick-b in decreasing pain and anxiety during cannulation.

peripheral intravenous cannulation (pivc), one of the most common therapeutic procedures in medical care, can be difficult even for experienced medical practitioners. the pain of intravenous cannulation is considered the major limitation in pediatric clinical care. reducing the pain of intravenous cannulation has been the motive for many investigations. intervention methods used to reduce the distress related to painful procedures are widely recommended. the management of pain and anxiety is more essential because it may modify children's memory for procedural pain and the subsequent acceptance of later health care painful interventions. distraction is the most studied psychological technique to relieve venipuncture-related pain and distress, with strong evidence supporting its efficacy in children. art therapy commonly used to reduce pain and anxiety of children's disease but was not used in reducing distress outcomes of painful procedures. we used a collection of the image need for coloring and tracing called trace image and coloring for kids-book (tick-b). the purpose of this study is to exam the effectiveness of tick-b in decreasing pain and anxiety during cannulation.

Eligibility criteria:
inclusion criteria: * pediatric patients 6-12 years old, * pediatric who needed peripheral cannulation, exclusion criteria: * children with chronic conditions, * impairments physical, * disabilities with communicating difficulties, * those whose parent not participated, * neurodevelopmental delayed, can't verbal speak, hearing or visual impairments, * children with coma or drowsiness, * have to take analgesic medication for less than 6 hrs. * history of syncope.
a study to evaluate efficacy and safety of gsk3858279 in diabetic peripheral neuropathic pain

Conditions: Pain

Summary: this is a multicenter randomized, double-blind, placebo-controlled phase 2 study to evaluate efficacy, safety, tolerability, pharmacokinetics, and target engagement of gsk3858279 in adult participants with chronic diabetic peripheral neuropathic pain (dpnp). the primary objective of the study is to assess the efficacy of gsk3858279 in participants with dpnp who have been unable to sufficiently manage their pain.


Eligibility criteria:
inclusion criteria: * participant must be 18-75 years of age inclusive, at the time of signing the informed consent. * type i or type ii diabetes with painful, distal, symmetrical, sensory motor neuropathy attributed to diabetes, of at least 6 months duration. * a pain score ≥4 and less than or equal to (≤) 9 by the 11-point nrs (0-10) for average daily pain intensity over the past 24 hours at the screening visit. * body mass index (bmi) within the range 18-40 kilogram per meter square (kg/m\^2) (inclusive) * capable of giving signed informed consent. exclusion criteria: * history or presence of cardiovascular, renal, gastrointestinal, lymphatic disorders which in the opinion of the investigator would interfere with the study procedures and/or assessments. * participant has current painful peripheral neuropathy due to a cause other than diabetes (e.g. pernicious anemia, hypothyroidism, post-herpetic neuralgia). * history of significant allergies to monoclonal antibodies. * current enrolment or past participation in a clinical study of an investigational medicinal product intervention within the last 30 days or 5 half-lives (whichever is longer) of signing consent. * participants who are unlikely to comply with the protocol (e.g. uncooperative attitude, inability to return for subsequent visits, inability to complete the ediary daily etc.) and/or otherwise considered by the investigator to be unlikely to complete the study.

Keywords: diabetes neuropathic pain diabetic peripheral neuropathic pain (dpnp) 214221 gsk3858279 efficacy safety pharmacokinetics tolerability