Kornimate/medical-research-clean huggingface dataset:
sirolimus eluting stenting in acute myocardial infarction

Conditions: Myocardial Infarction

Summary: the incidence of stent restenosis in the setting of primary angioplasty is particularly high, reaching a rate of 27% in the last years the introduction of drug-eluting stents has drastically reduced the incidence of restenosis in patients not requiring urgent revascularization. whether drug-eluting stenting might constitute the new optimal therapy for patients with an acute myocardial infarction is unknown. to be able to answer this question, we designed a randomized trial in which patients with an acute myocardial infarction eligible for treatment with primary angioplasty and abciximab were randomized to receive either a rapamicine-eluting stent or a conventional bare stent.

the treatment of acute myocardial infarction has evolved dramatically in the last decade. coronary angioplasty with stent implantation in conjunction with an optimal antitrombotic therapy as abciximab is now considered current standard therapy however, the incidence of stent restenosis in the setting of primary angioplasty remains particularly high, reaching a rate of 27%. a high restenosis rate causes a high re-hospitalization rate for target vessel revascularization and an ensuing increase in cost.in the last years the introduction of drug-eluting stents has drastically reduced the incidence of restenosis in patients not requiring urgent revascularization. this reduced incidence of restenosis occurs without an increase in adverse clinical events over conventional stents and has a very low rate of stent subacute thrombosis. whether this combination of drug-eluting stents and abciximab might constitute the new optimal therapy for patients with an acute myocardial infarction is unknown. to be able to answer this question, we designed a one year coronary angiographic study in which patients with an acute myocardial infarction eligible for treatment with primary angioplasty and abciximab were randomized to receive either a rapamicine-eluting stent or a conventional bare stent.

Eligibility criteria:
inclusion criteria: inclusion criteria were an age of more than 18 years, the presence for at least 30 minutes but less than 12 hours of symptoms consistent with acute myocardial infarction, and the presence of st-segment elevation in at least two contiguous leads or left bundle-branch block. - exclusion criteria: patients were excluded if they were in cardiogenic shock (defined as systolic blood pressure of less than 80 mm hg for more than 30 minutes or the need for intravenous pressors or intraaortic-balloon counterpulsation); had a history of bleeding diathesis; had a history of leukopenia, thrombocytopenia, or severe hepatic or renal dysfunction; had a noncardiac illness associated with a life expectancy of less than one year; were participating in another study; or were unable to give informed consent owing to prolonged cardiopulmonary resuscitation. -

Keywords: myocardial infarction stents sirolimus abciximab
neuroplastic change in myelin of the brain

Conditions: Stroke

Summary: the main goal of this research is to advance understanding of how stroke changes both the structure and function of the brain. the investigators will determine which is the key driver of recovery of arm function after stroke: changes in the structure of the brain or changes in how brain regions interact with one another.

the main goal of this research is to advance understanding of how stroke changes both the structure and function of the brain. further, the investigators will determine which is the key driver of recovery of arm function after stroke: changes in the structure of the brain or changes in how brain regions interact with one another. together, these data will advance the investigators understanding of how neural systems support recovery from stroke. the investigators will use a mri technique that allows us to assess the health of a brain structure called myelin. this structure is important as it allows information to travel down nerves faster; the more myelin the quicker the signal can be conducted. the investigators aim is to test whether or not movement training can restore myelin in the brain. if movement training does restore myelin in the brain, the investigators will have identified an important new target for rehabilitation interventions.

Eligibility criteria:
inclusion criteria: * individuals aged 40-75 * movement-related deficits associated with a middle cerebral artery stroke * first time stroke affecting the corona radiata and/or internal capsule * fugl-meyer upper extremity motor score of at least 15 but not greater than 55. exclusion criteria: * outside the age range of 40-75 * show signs of dementia (score \< 24 on the montreal cognitive assessment) * have aphasia (score \< 13 on the frenchay aphasia screen) * history of head trauma, a major psychiatric diagnosis, neurodegenerative disorder or substance abuse; * taking any drugs (gabaergic, n-methyl-d-aspartate a-receptor (nmda) antagonist) known to influence neuroplasticity; * report contraindications to mri (see supporting documents)

Keywords: neuroplastic change myelin
a safety and efficacy study of liris® in females with interstitial cystitis/bladder pain syndrome

Conditions: Cystitis, Interstitial; Painful Bladder Syndrome

Summary: this is a safety and efficacy study of liris® in females with interstitial cystitis/bladder pain syndrome.


Eligibility criteria:
inclusion criteria: * diagnosis of interstitial cystitis or bladder pain syndrome exclusion criteria: * diagnosis of interstitial cystitis with hunner's lesions/ulcers * previous treatment with liris®
earlobe creases predict prognosis in chinese patients with acute myocardial infarction

Conditions: Ear Abnormalities; Prognosis

Summary: to investigate the feasibility of the earlobe crease as an early prognostic predictor for acute myocardial infarction(ami) in chinese population.

primary objective : 1 year primary composite end point (including the whole death, recurrent myocardial infarction, stroke, target vessel revascularization, stent thrombosis) in ami patients with different types of earlobe crease. secondary objective: 1. the incidence of complications during hospitalization 2. the rate of rehospitalization due to cardiovascular disease 3. the incidence of revascularization at 1 year after ami

Eligibility criteria:
inclusion criteria: 1. initial acute myocardial infarction(ami) 2. detection of a rise and/or fall of cardiac biomarker values (preferably cardiac troponin (ctn) with at least one value above the 99th percentile upper reference limit (url)) and with at least one of the following: * symptoms of ischemia * development of pathologic q waves in the electrocardiogram (ecg) * new or presumed new significant st-segment-t wave (st-t) changes or new left bundle branch block (lbbb). * identification of an intracoronary thrombus by angiography or autopsy * imaging evidence of new loss of viable myocardium or a new regional wall motion abnormality. 3. type 1 (spontaneous myocardial infarction(mi)) in the third universal definition of mi: mi consequent to a pathologic process in the wall of the coronary artery (eg, plaque erosion/rupture, fissuring, or dissection), resulting in intraluminal thrombus. 4. infarct related artery (ira) showed that acute thrombus formation, ira occlusion or stenosis ≥95%、≥90%～95%、≤90%，thrombolysis in myocardial infarction (timi)0-3 flow. 5. pci(percutaneous coronary intervention)intervention（pci for stemi within 12 hours after symptom onset）. 6. signed informed consent. exclusion criteria: 1. combined valvular heart disease, cardiomyopathy, blood diseases, skin diseases, rheumatic diseases, ischemic cerebrovascular disease, tumor, etc. 2. previous myocardial infarction. 3. previous pci and coronary artery bypass graft(cabg). 4. chronic total occlusion(cto)lesions. 5. ear malformation. 6. ocular diseases. 7. participating in a clinical study.

Keywords: earlobe crease acute myocardial infarction
the role of octa in patients affected by beta thalassemia

Conditions: Thalassemia

Summary: to investigate, using optical coherence tomography angiography (octa), the retinal and choriocapillaris vascular features in patients affected by beta thalassemia. moreover we analyzed the structural retinal parameters (ganglion cell complex and retinal nerve fiber layer), using optical coherence tomography (oct) in these patients

beta thalassemia is one of the most common genetic hemoglobinopathy characterized by a defective β globulin chain synthesis leading to hemolysis and ineffective erythropoiesis. the study investigated the changes in retinal and choriocapillaris vascular features using optical coherence tomography angiography, a novel and noninvasive diagnostic technique that allows a detailed analysis of retinal and choriocapillaris blood flow.

Eligibility criteria:
inclusion criteria: * age older than 35 years * diagnosis of beta thalassemia * absence of previous ocular surgery, congenital eye disease, high myopia (\>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases. * absence of significant lens opacities, low-quality oct and oct-a images. exclusion criteria: * age older than 50 years * absence of diagnosis of beta thalassemia * presence of previous ocular surgery, congenital eye disease, high myopia (\>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases. * presence of significant lens opacities, low-quality oct and oct-a images.
efficacy of synthetic bone graft for treatment of peri-implantitis

Conditions: Peri-Implantitis

Summary: single arm study to evaluate the effectiveness of treatment approach using a new moldable beta-tricalcium phosphate(tcp) bone graft material and polylactide membrane in peri-implantitis.


Eligibility criteria:
inclusion criteria: * subject has read and signed the institutional review board approved consent form before treatment. * subject must be age 21 or above. * subject must be willing and able to follow study procedures and instructions. * subject affected by moderate to severe peri-implant disease. * treated chronic periodontitis and proper periodontal maintenance care. * dental implant must meet the following criteria to be selected for the study: 1. implant presenting probing depth ≥ 6 mm 2. radiographic implant bone loss more than 25% of the implant length (apex of the implant to implant platform) . 3. peri implant bone defect being a buccal dehiscence and semicircular bone resorption to the middle of the implant body, buccal dehiscence and circular bone resorption with lingual bone plate intact or circular bone resorption with buccal and lingual bone plates intact 4. single tooth implant restoration or implant supported fixed partial denture. exclusion criteria: * subjects participating (currently or within 30 days prior to enrollment) in other clinical trials involving therapeutic intervention (either medical or dental). * subjects with poor oral hygiene as indicated by a score of greater than 50% on the o'leary plaque index. * subjects with a systemic condition, which would preclude periodontal treatment, including but not limited to uncontrolled diabetes. * subjects with acute infectious lesions in the areas intended for treatment. * subjects taking chronic (i.e., \> 2 weeks), therapeutic doses of medications known to affect bone metabolism such as nonsteroidal anti-inflammatory drugs or bisphosphonates. prophylactic aspirin (≤ 325 mg q.d.) for cardiovascular indications will be permitted in subjects. * female subjects who are pregnant or lactating, or sexually-active female subjects who are of childbearing potential and are not using hormonal or barrier methods of birth control. (except for when a result of pregnancy test is negative) * subjects who are on any chronic antibiotic or steroidal therapy. * smoker using more than 10 cigarettes or equivalent per day. * smoker using cigar, smokeless tobacco use or e-cigarette. * subjects diagnosed with drug induced gingival hyperplasia (e.g. calcium channel blockers). * subjects with radiographic evidence of pathology in other areas of the mouth besides implant area to be treated. * implant mobility. * subjects with parafunctional habits and not wearing bite guard.
polymer induced liquid precursor (pilp) in adults in with dentin caries

Conditions: Dental Caries

Summary: the goal of this clinical trial is to learn if polymer-induced liquid precursor (pilp) can be used safely to treat dentin caries (cavities) in adults. the main question it aims to answer is: is pilp (conditioner or liner) safe in adult teeth with dental caries? researchers will compare pilp to a placebo (a look-alike substance that contains no drug) to see if pilp safely treats cavities in teeth. participants will: 1) have pilp or placebo applied to their tooth prior to the placement of a filling in the tooth, 2) complete two telephone calls within three months of filling placement and 3) visit the clinic at three months and six months after the placement of the filling.

the proposed study is a first-in-human safety evaluation of polymer-induced liquid precursor (pilp)-releasing dental materials for the treatment of deep carious lesions in adult posterior teeth. the study will enroll adult patients diagnosed with carious lesions involving the dentin. participants will be randomly assigned to one of three intervention groups. the primary objective is to assess the safety of pilp application, with a hypothesis that pilp can be safely used without causing adverse events to the tooth or patient. participants will undergo a series of visits starting with a comprehensive screening and consent process, followed by the assigned dental procedure involving caries removal and restoration. follow-up evaluations will occur at 48 hours, 1 month, 3 months, and 6 months post-procedure to monitor for any symptoms or adverse outcomes.

Eligibility criteria:
inclusion criteria: 1. stated willingness to comply with all study procedures and availability for the duration of the study 2. male or female, aged 18 to sixty-four 3. in good general health as evidenced by medical history (asa 1 or 2) 4. with at least one posterior tooth with caries to dentin 1. the tooth must have a pulpal diagnosis of pulpal health (no irreversible pulpitis or periapical radiolucency) 2. the tooth should have no existing restorations 3. the caries should be a class i or class v single surface lesion 4. the tooth should be planned for restoration with intra-coronal restoration (composite or rmgi restoration) 5. the tooth should be deemed as needing a restoration based on icdas (international caries detection and assessment system) exclusion criteria: known allergic reactions to components of the study device
prospective registry of elderly esus with pfo

Conditions: Embolic Stroke of Undetermined Source

Summary: patent foramen ovale (pfo) is associated with an increased risk of stroke. pfo-closure was effective in preventing stroke in young stroke patients less than age 60 presented as an embolic stroke of undetermined source (esus). however, the benefit of pfo-closure in elderly esus patients is not clear. the investigators designed this prospective register-based observational study to verify the efficacy of pfo-closure in elderly esus patients with high-risk pfo, older than 60 years

the coach-elderly esus study is a multicenter, prospective, registry-based, observational study in elderly esus patients with high-risk pfo treated with pfo-closure + standard antiplatelet treatment or standard antiplatelet treatment only in 20 centers in korea. patients will receive an insertable loop recorder (ilr) to monitor paroxysmal atrial fibrillation. in cases, which are unavailable for ilr, recurrent ekg or holter monitoring will be done based on the clinician's decision. based on the attending physicians' decision with a multi-disciplinary approach, patients will receive pfo-closure with standard antiplatelet treatment or standard antiplatelet treatment only.

Eligibility criteria:
inclusion criteria: 1. patients older than 60 years-old 2. patients diagnosed as esus within 180 days from onset 3. pfo found from tte or tee, which attributed to the ischemic stroke 4. patients or their legal representative agreed to participate exclusion criteria: 1. patients with transient ischemic attack 2. patients with ischemic stroke at the vascular territory with significant stenosis 3. patients with high risk cardioembolic stroke detected from ekg, holter monitoring or echocardiography 4. patients with other causes which may cause stroke (i.e. vasculitis, dissection, vasospasm, drug related or moyamoya disease) 5. patients with active cancer 6. patients who need long term anticoagulation 7. patients who have side effect on antiplatelet treatment 8. patients with active internal bleeding 9. patients who refuse to participate

Keywords: insertable loop recorder patent foramen ovale patent foramen ovale closure elderly
treatment and control of atopic dermatitis with 0.1% tacrolimus ointment

Conditions: Dermatitis, Atopic

Summary: long-term tacrolimus ointment based regimen comprising of up to 6 weeks of initial twice daily treatment and subsequent twice weekly prophylactic application can effectively treat active lesions of atopic dermatitis and prevent delay \& reduce flares


Eligibility criteria:
inclusion criteria: * male or female patient of any ethnic group * patient was at least 16 years old and suffered from mild to severe atopic dermatitis (rajka/langeland score of at least 3) exclusion criteria: * patient had a genetic epidermal barrier defect such as netherton's syndrome or generalised erythroderma * patient had a clinically significant skin infection on the affected (and to be treated) area

Keywords: dermatitis, atopic tacrolimus adult treatment outcomes
evaluation of the efficiency of intermittent enteral nutrition on multi-organ failure from patients with mechanical ventilation in intensive care unit

Conditions: Intermittent Fasting; Septic Shock; Organ Failure, Multiple

Summary: this study aims to evaluate the efficiency of intermittent enteral nutrition versus continuous enteral nutrition to prevent from organ failures for patients at the acute phase of sepsis shock with mechanical ventilation in icu.

some pre-clinical and observational studies have suggested that intermittent fasting may have a positive impact on patients in icu by increasing protein synthesis, sensibility to insulin, cetogenesis, autophagy by respecting the circadian rhythm. this study aims to evaluate the impact on organ failures of an intermittent enteral nutrition versus continuous enteral nutrition in patients at the acute phase of sepsis shock with mechanical ventilation in the icu.

Eligibility criteria:
inclusion criteria: * patient admitted in icu for less than 48h, with invasive mechanical ventilation predicted for at least 48h, that can undergo nasogastric feeding. * patient under vasopressive drugs * patient that signed collected * patient under healthcare system * age ≥ 18 years * affiliation to a social security scheme * patient who has read and understood the information letter and signed the consent form exclusion criteria: * oesophageal varices or occlusive syndrom * impossibility to start enteral feeding within 48h after admission in the icu * enteral nutrition started for more than one hour * parenteral nutrition * pregnant or parturient or breastfeeding woman or proven absence of contraception

Keywords: enteral nutrition mechanical ventilation intermittent fasting sepsis shock organ failure
effect of parecoxib on the change of shoulder pain threshold after gynecological laparoscopies

Conditions: Postoperative Pain Management, Pain Threshold, Shoulder Pain, Laparoscopies

Summary: this prospective, double blind, placebo-controlled, parallel group study will be conducted in the first affiliated hospital of sun yat-sen university in guangzhou, china. patients aged 18-65 (asa i-ii) undergoing elective gynecologic laparoscopic surgery with general anesthesia will be involved in this study. according to previous studies and our pilot trial, estimated 120 patients will be involved in this study. all eligible patients will be randomly assigned to two groups. in group p, patients will receive parecoxib 40mg intravenously 30min before intubation, 8h and 20h after the surgery,respectively. in group c, patients will receive normal saline at the same time points. the shoulder pressure pain thresholds will be measured with a pressure algometer by an independent doctor blinding to medication and grouping at the day before surgery, 24h and 48h after surgery. moreover, the intensity of shoulder pain and side effects will be evaluated by another independent doctor at 24h and 48h after surgery. at the end of the observation, the intensity of the maximal shoulder pain will be assessed.


Eligibility criteria:
inclusion criteria: * females age 18-65yr, * american society of anesthesiologists (asa)i-ii, * body mass index(bmi) 18-25kg/m2. exclusion criteria: * a history of severe cardiac, pulmonary, hepatic, renal disease, chronic drug or alcohol abuse; * the presence of preoperative shoulder pain or any chronic pain syndrome, long-term use of analgesics; allergy or contraindications to nonsteroidal anti-inflammatory drugs (allergy, peptic ulcer disease, gastroesophageal reflux disease, renal insufficiency, coagulopathy) and any other drugs used in the study; * patient's pain evaluation is judged unreliable; * patients with conversion to a laparotomy; * refuse to coordinate with the follow-up tests.

Keywords: nsaids hyperalgesia postlaparoscopic shoulder pain
cognitive behavioral therapy on adherence and depression (cbt-ad) among hiv/aids patients

Conditions: Depression; Medication Adherence

Summary: depression is highly comorbid with hiv/ aids and is associated with worse poor adherence to antiretroviral therapy (art), and potentially to long-term immune functioning. cognitive behavioral therapy may solve these problem.

depression is highly comorbid with hiv/ aids and is associated with worse poor adherence to antiretroviral therapy (art), and potentially to long-term immune functioning. poor adherence decreases the benefits of art as well as chances of prolonged survival. an intervention that integrates cbt for depression with a cognitive behavioral approach to adherence counseling (cognitive behavioral therapy intervention for adherence and depression (cbt-ad)) has been found to be effective in improving adherence and reducing depression in plwh.

Eligibility criteria:
inclusion criteria: * plwha who were 18 years old and above were included in the study exclusion criteria: * plwha who were previously took cbt and participants with acute physical or mental disturbances were excluded.
cgm dynamic index for predicting prediabetes in cystic fibrosis

Conditions: Prediabetes; Cystic Fibrosis (CF); Cystic Fibrosis-related Diabetes

Summary: the primary objective of this pilot study is to develop a cgm-based model to predict the progression from prediabetes to diabetes in individuals with cystic fibrosis.


Eligibility criteria:
inclusion criteria: * cf individuals aged 12-55 years. * cf without diabetes or with prediabetes (as defined by ogtt and hba1c). * willing to use a continuous glucose monitoring system with compatible smart phone for glucose data collection. a person with cfrd and already using cgm, we will just collect their personal cgm data, and they are not required to have ogtt or hba1c visit. exclusion criteria: * pregnancy. * history of transplant. * use of immunosuppressant drugs. * use of oral steroids or any medication known to interfere with glucose. * allergy to adhesives. * individuals with severe concurrent medical conditions that could confound glucose monitoring data (e.g., terminal illness, major organ failure). * conditions that may make unsafe for participants to do study or impair or confound the study at the discretion of the investigator