Kornimate/medical-research-clean huggingface dataset:
inf108f in infants with food protein induced proctocolitis

Conditions: Infant Development; Gut Microbiome; Food Protein Induced Allergic Proctocolitis

Summary: single-center, randomized, double-blind, placebo-controlled trail evaluating inf108f in breastfed infants with fpiap

this is a single-center, randomized, double-blind, placebo-controlled trial with two arms evaluating ibf108f in breastfed infants with fpiap. assessments will be conducted over a 4-week study period with assessment of blood in stool, infant stooling, sleep, feeding, and growth. safety will be evaluated through collection adverse events.

Eligibility criteria:
inclusion criteria: * infants, male or female, of all ethnic/racial groups, with a gestational period of 37 to 42 weeks * infants aged 1 - 90 days old with a documented fpiap with either gross blood or microscopic blood in without other possible causes * infants must be exclusively breastfed or at least half of oral intake is from breast feeding or from expressed breast milk * a willing parent or legal guardian will sign the consent form either electronically or with a wet ink signature exclusion criteria: * infants born earlier than 37 weeks of gestation * infants who are exclusively formula-fed or less than half of oral intake is from breastfeeding or from expressed breast milk at the time of enrollment * infants born with medical complications (i.e., neurological, cerebral palsy, confirmed food allergies) * diagnosis of other severe or complicating medical problems, including autoimmune or chronic immune inflammatory conditions, gastrointestinal inflammatory conditions, or renal insufficiency * history of abdominal surgery or congenital abnormalities of the gi track, the cardiovascular system, the pulmonary system or the renal system * antibiotic use (oral or systemic) within 7 days prior to enrollment * mother's intent to feed non-study probiotics or solid food to their infant at any time during the study * mothers with substance use disorder (sud) or on nicotine replacement therapy (nrt) * infants who have consumed any b. infantis-containing probiotics since birth
osteoarthritis: weakness from inflammation

Conditions: Osteoarthritis

Summary: the purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.

through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. we hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure. this study requires 1 four-hour visit to harbor hospital. the visit involves a physical exam, a dexa bone density scan, blood and urine testing, knee x-rays, strength testing and a surface electromyography (emg). samples of muscle, joint fluid and joint tissue will be collected during your planned surgery. participation in this study is entirely voluntary.

Eligibility criteria:
inclusion criteria: * 50 years of age or older * normal body weight (a body mass index (bmi) of 30 or less) * osteoarthritis of the knee (prior to knee surgery) * planning to have knee surgery at a medstar hospital exclusion criteria: * history of a stroke * history of muscle weakness or paralysis * history of rheumatoid arthritis or * inflammatory joint disease * history of a bleeding disorder * history of gout * diabetes for which you take insulin * polymyalgia rheumatica (total body muscle aching/stiffness)

Keywords: knee osteoarthritis muscle cytokine mobility function
professional quality of life in german psychologists

Conditions: Mental Disorder; Burnout, Caregiver; Burnout, Professional

Summary: the purpose of this study is to assess professional quality of life in german psychologists working with patients with mental disorders.

the purpose of this study is to assess professional quality of life, which includes compassion satisfaction, burnout and secondary traumatization in clinical psychologists, working with patients with mental disorders, in germany.

Eligibility criteria:
inclusion criteria: * clinical psychologist * currently working with patients with mental disorders * at least 18 years old * sufficient german skills for answering the questionnaire exclusion criteria: none

Keywords: professional quality of life compassion satisfaction burnout psychologists mental disorders mental health
physical activity behavior of rheumatoid arthritis patients and healthy controls

Conditions: Rheumatoid Arthritis

Summary: the purpose of the study is to compare physical activity behaviour of rheumatoid arthritis patients with healthy matched controls.


Eligibility criteria:
inclusion criteria (ra patients): * rheumatoid arthritis * functional classes i, ii and iii * age 40 to 80 years * stable disease activity * stable dmards last 3 months exclusion criteria (ra patients): * functional classes iv * inflammatory flare

Keywords: rheumatoid arthritis, physical activity
prevention and screening towards elimination of cervical cancer

Conditions: HPV Infection; Cervix Cancer; Cervical Dysplasia

Summary: the research project applies the protocol of the world health organisation for screening of cervical cancer, with testing of hrhpv as first screening, followed by visual inspection of the cervix with acetic acid for hrhpv-positive women and for women with minor lesions thermo-ablation of affected areas. this procedure is applied in uganda, india and bangladesh. in slovakia hrhpv-positive women are offered pap-smear and for women with pap iv lis excision.

the project performs community sensitisation and mobilisation in dedicated geographical areas and populations, to inform women and relatives about the importance of screening for cervical cancer. to eligible women self-tests for hrhpv are offered, which can be applied at home and investigated in dedicated field-laboratories. women who are hrhpv positive are invited for further diagnosis. in uganda, india and bangladesh visual inspection of the cervix with acetic acid is performed. in slovakia pap-smear. in case dysplasia is found, further treatment is performed with cryotherapy or thermo-ablation. cases of suspect invasive cervical cancer are referred to hospitals for diagnosis and treatment.

Eligibility criteria:
inclusion criteria: * female in eligible age group * ability to give informed consent and participate in study exclusion criteria: * clinical signs of cervical carcinoma * menstruation or other vaginal blood loss

Keywords: hrhpv test screening cervical cancer visual inspection cervix acetic acid thermo-ablation cryotherapy
effect of topical anesthesia on patient's pain discomfort and radial artery spasm in transradial catheterization

Conditions: Radial Artery Spasm

Summary: this study evaluate topical anaesthesia application for 30 minutes before tranradial catheterization during cardiac catheterization can reduce pain and decrease radial artery spasm

the incidence of radial artery spasm (ras) has varied from 5-30% ras refers to friction between the artery and wires or guide catheters accompanied by a subjective feeling of pain. emla anesthetic ointment (ao-astra zeneca) is an emulsion of lidocaine 2.5% and prilocaine 2.5% in a ratio of 1:1 by weight previous study showed that emla cream can increase the success rate of femoral cannulation in children.

Eligibility criteria:
inclusion criteria: * patients age \>18 years. * patients who was schedule to performed coronary angiogram exclusion criteria: previous ipsilateral transradial approach raynaud's syndrome esrd history of sensitivity to local anesthetics non-palpable redial pulse abnormal barbeau's test local site infection patient's refusal
irinotecan, gemcitabine and radiation therapy for pancreatic cancer

Conditions: Pancreatic Cancer

Summary: the study hypothesis is that chemoradiation based on 2 drugs will improve local control and long-term survival in patients with locally advanced pancreatic cancer. that is why gemcitabine and irinotecan are combined in an induction phase of 2 months and then this irinogem combination is given for 3 more cycles, in reduced doses,concurently with irradiation.


Eligibility criteria:
inclusion criteria: * locally advanced pancreatic cancer * performance status 0-2 * normal blood count and chemistry * no previous chemotherapy or radiotherapy exclusion criteria: * serious concurrent systemic disease

Keywords: carcinoma pancreas chemotherapy radiotherapy
alteration of the immune microenvironment in basal cell carcinoma following photodynamic therapy

Conditions: Basal Cell Carcinoma

Summary: the purpose of this study is to better understand the immune response to basal cell carcinoma (bcc) treated with photodynamic therapy (pdt) in order to develop new methods of treating bcc. previous research suggests that pdt alters the immune response, possibly in a way that could promote better tumor clearance when combined with other treatments. overall, participation in this study will help the study team better understand the anti-tumor immune response when bcc is treated with pdt.

pdt is a technique that works by combining a photosensitizing topical agent and an intense light to kill tumor cells. pdt is not currently approved for the treatment of bcc by the food and drug administration (fda), although it is approved for that purpose in many european countries. this is an internally (bilaterally) controlled trial that will enroll 24 participants with biopsy-proven bcc who are planning to undergo tumor removal via mohs surgery. within this cohort, one tumor will be pdt-treated and the other left as an untreated control. this study is also a cohort-controlled trial, because discarded tissue from fully de-identified mohs participants will be analyzed after routine mohs surgery, in order to establish the baseline variability in tumor-infiltrating immune cell parameters in non-pdt-treated participants. the objectives of this study are: to determine the time to maximum expression of immune checkpoint molecules in bcc tumors and peri-tumoral stroma after pdt, as compared to untreated tumors. to determine the ratio of cytotoxic t cells to regulatory t cells in bcc tumors and peri-tumoral stroma after pdt, as compared to untreated tumors. to determine whether circulating t-cells, collected from patients' peripheral blood, sampled before and after pdt treatment of a bcc tumor, show a higher proportion of tumor-activated cd8+ t-cells after pdt. the hypothesis is that pdt of the localized tumor will trigger a systemic anti-tumor immune effect. to determine the rate of protoporphyrin ix (ppix) accumulation and maximal ppix levels.in tumors to determine the rate of production and maximal levels of singlet oxygen (o2) produced during blue light exposure to assess change in the volume, color, and appearance of tumors at the mohs surgery visit compared to the pdt visit to assess for distant tumor (abscopal) effects after pdt

Eligibility criteria:
inclusion criteria: * adults scheduled to undergo mohs surgery within the dermatologic surgery unit of the department of dermatology, cleveland clinic * must have at least one bcc tumor eligible for removal by surgical excision * men and women of any ethnic group are eligible * must provide informed consent to participate exclusion criteria: * pregnant or breastfeeding * currently being treated for other cancers with medical or radiation therapy * known hypersensitivity to 5-aminolevulinic acid (ala) * history of a photosensitivity disease, e.g.,porphyria cutanea tarda
project asthma - aligning with schools to help manage asthma and decrease health inequities

Conditions: Asthma in Children; Directly Observed Therapy

Summary: children with asthma from communities that experience health inequities frequently do not receive guideline-based asthma care, and as a result, account for a disproportionate percentage of asthma exacerbations, emergency department visits, and hospitalizations. project asthma (aligning with schools to help manage asthma) tests the effectiveness of school-based health centers as a delivery model to improve health outcomes by providing children with guideline-based asthma assessments and preventive medication management, directly observed therapy of their preventive medication to support adherence, and self-management support. if successful, this multicomponent intervention will represent a cost effective and sustainable model to reduce asthma morbidity in historically marginalized communities, and has the potential to impact communities throughout the united states where over 2,500 school-based health centers operate.


Eligibility criteria:
inclusion criteria: * uncontrolled asthma exclusion criteria: * other chronic lung disease such as cystic fibrosis

Keywords: asthma children school-based health center nih guideline-based care controller medication directly observed therapy
intrathecal morphine for cesarean delivery

Conditions: Postoperative Pain

Summary: this is a randomized double blinded non-inferiority study comparing the duration of pain relief when patients receive one of three doses of spinal morphine. enrolled patients will be randomly assigned to receive either 50 mcg, 150 mcg, or 250 mcg. all patients will receive standardized postoperative care, including multimodal analgesia. the primary outcome will be the time until the patient requests additional opioid pain medications.

prospective, randomized, double-blind, controlled trial, with a non-inferiority design. patients will be randomly assigned to receive either intrathecal morphine 50 mcg, 150 mcg, or 250 mcg based on a pre-assigned randomization sequence. this medication will be administered as part of their spinal anesthesia for cesarean delivery. the patient, clinician who administers the spinal anesthesia, and investigator who follows the patient will all be blinded to the dose of medication. all patients will receive standard of care for cesarean delivery and routine nursing care. this includes: preoperative intravenous catheter placement with preoperative iv fluid, standard american society of anesthesiologists monitoring, and neuraxial anesthesia placement (either spinal or combined spinal epidural) in sterile fashion. each patient will receive standard cesarean induction dose of intrathecal medication consisting of 1.5ml of 0.75% hyperbaric bupivacaine, fentanyl 25 mcg. at end of surgery, all patients will receive standard dose of ketorolac 30 mg iv and acetaminophen 1 gm iv and continue with redosing every 6 and 8 hours (respectively) for 24 hours. on arrival to pacu, all patients will receive standard nursing care with standard monitoring of side effects. on discharge from pacu, patients will be transferred to postpartum floor and receive standard nursing care and monitoring. over the following 24 hours, the patient will receive all standard post-cesarean care. for treatment of breakthrough pain, medications will provided be per standard care: oxycodone 5-10 mg po every four hours prn for pain. if the patient is not comfortable after receiving oral oxycodone they will be assessed by an anesthesia provider for either regional nerve block or additional opioids, as a one-time dose or by patient controlled analgesia (pca). for treatment for side effects, medications will provided be per standard care: ondansetron 4mg iv as first-line for nausea/vomiting, promethazine 6.25 mg iv or haloperidol 0.5-1mg iv for refractory nausea/vomiting. naloxone 0.04 mg iv for refractory pruritus.

Eligibility criteria:
inclusion criteria: * healthy women (asa 2) * between 18 and 45 years old * singleton term pregnancies * planned neuraxial anesthesia exclusion criteria: * refusal to participate * known allergy or contraindication to any medication used in the study * significant medical or obstetrical disease (asa ≥ 3) * opioid use disorder * chronic pain syndrome * daily or near daily opioid use within last 3 weeks. * patient receiving a monoamine oxidase inhibitors (moai)

Keywords: cesarean morphine multimodal analgesia
ghrelin regulation and structure: effect of diet composition on ghrelin

Conditions: Obesity

Summary: the purpose of this study is to learn more about how diet affects the hormone ghrelin. ghrelin is made in the stomach and causes appetite to increase. learning about ghrelin will help the investigators understand more about obesity.

control subjects will be provided 3 different diets for 2 weeks each. at the end of each diet period participants will be admitted to ohsu clinical translation research center (ctrc) for blood sampling every 30 minutes for 13.5 hours, to measure levels of hormones. participants will also have a dxa scan to measure body composition. pws subjects will have one admission after eating a standardized diet prepared by caregivers for 2 weeks.

Eligibility criteria:
inclusion criteria: * age 18 or older. * weight stable for at least 3 months. * at lifetime maximal body weight. exclusion criteria: * actively losing weight by diet or exercise. * smokers. * alcohol consumption \> 2 drinks per day. * exercise \> 30 minutes 3 times a week. * prescription drug use (except birth control pills, vitamins, or minerals). * type 2 diabetes. * heart disease, cancer, malabsorptive states, or chronic infections that would affect body weight. * weight \> 300 lbs (exceeds the weight limit of the dexa machine). * hemoglobin \< 12.0 g/dl for women, \< 13.5 g/dl for men
effect of aspirin pretreatment or slow dose titration on flushing and gastrointestinal events in healthy volunteers receiving delayed-release dimethyl fumarate

Conditions: Healthy

Summary: the primary objective of the study is to evaluate whether premedication with 325 mg microcoated aspirin (asa) tablet or a slow-titration dosing schedule of bg00012 reduces the incidence and severity of flushing and gi events following oral administration of bg00012 dosed at 240 mg twice a day (bid) in healthy volunteers. the secondary objective of this study is to evaluate the safety and tolerability of bg00012 when administered orally as a 240 mg bid dose regimen with and without 325 mg asa premedication or following a slow-titration dosing schedule in healthy volunteers.


Eligibility criteria:
key inclusion criteria: * must give written informed consent and any authorizations required by local law * must have a body mass index (bmi) of between 18.0 to 34.0 kg/m\^2,inclusive. * ability to complete the tolerability scales by accurately using the hand-held subject reporting device * subjects of childbearing potential must be willing to practice effective contraception key exclusion criteria: * history of clinically significant diseases * history of severe allergic or anaphylactic reactions * intolerance to aspirin or nonsteroidal anti-inflammatory drugs (nsaids) * diarrhea, constipation, abdominal pain, flushing or nausea within 28 days prior to day 1 note: other protocol defined inclusion/exclusion criteria may apply.

Keywords: bg00012 gastrointestinal events flushing events dose titration pre-medication aspirin
validation of drug assays in various biological matrices

Conditions: Infection

Summary: this study aims to ensure that assays that measure drug concentrations are accurate and precise in different matrices when quantified using high performance liquid chromatography -tandem mass spectrometry (hplc-ms/ms). the study involves collecting samples of various bodily fluids to quantify antimicrobials, antivirals, oral contraceptives and erectile dysfunction agents. samples will also be obtained from individuals not receiving these medications for quality control purposes.


Eligibility criteria:
inclusion criteria: * \> 18 years of age exclusion criteria: * unable to give informed consent
a comparative split-face study of the effects of a retinol alternative cream on improving facial skin aging

Conditions: Skin Aging

Summary: this study will evaluate the efficacy of the dime tbt cream in improving the appearance and hydration of aged skin in comparison to a retinol cream. this study will last for 60 days. the study will be conducted as a single-arm trial in which all participants will use both the test product and the positive control product (0.1% retinol clinical trial lotion). participants will be required to undertake questionnaires at baseline, day 30, and day 60. photos will be taken at baseline, day 30, and day 60, and expert skin grading will take place at baseline and day 60.


Eligibility criteria:
inclusion criteria: females aged 18-65. have one or more of the following: visible fine lines and wrinkles, dry skin, reduced skin elasticity, or generally unhealthy skin. must be willing to use two different skincare products, one on each side of their face for the duration of the trial. have a smartphone or camera to take before-and-after selfies. exclusion criteria: anyone not in good health. anyone who has any chronic health conditions such as oncological or psychiatric disorders. anyone who has any known serious allergic reactions that require the use of an epi-pen. anyone who is pregnant, breastfeeding, or wanting to become pregnant over the next three months. anyone who cannot/ will not commit to the study protocol. anyone with a history of substance abuse.
arterial doppler waveforms analysis in pad

Conditions: French Vascular Physicians

Summary: the main objective is to evaluate the differences of terminology used when describing arterial doppler waveforms. to assess the impact of an educational process

peripheral artery disease (pad) is a common pathology that affects more than 200 million people worldwide. the prevalence of this pathology is estimated in france at 11% in patients over 40 years old. the doppler arterial waveforms analysis is an important element to assess the hemodynamic state of a patient and contributes to the diagnosis of the pathology. a number of classifications have been proposed but their use varies from one university to another. we hypothesize that there is a great heterogeneity in the description of the arterial doppler flow analysis. in addition, a new classification (saint-bonnet) has recently been proposed and we will evaluate the effect of the use of this one. the main objective is to evaluate the differences of terminology used when describing arterial doppler waveforms. the secondary objectives are: to understand the variations observed and expected (initial, continuous training, place of exercise ...) and to study the effect of a new classification on the heterogeneity of responses.

Eligibility criteria:
inclusion criteria: * vascular physicians enrolled in the mailing list of french society of vascular medicine exclusion criteria: * no exclusion criteria

Keywords: vascular physicians peripheral artery disease classification doppler waveforms saint-bonnet
investigating reaction time among children who snore

Conditions: Snoring

Summary: the investigators feel that children who have osa or sleep-disordered breathing may have a different reaction time than normal variants. children who have osa are known to have behavioral and sleep patterns that are different. it makes sense their reaction time may be different than normal as well. we plan to measure reaction times via a 10 minute psychomotor vigilance test device in children who snore who are coming in for a sleep study or for adenotonsillectomy.


Eligibility criteria:
inclusion criteria: * ability to understand how to perform reaction time test and complete without assistance. exclusion criteria: * children who are unable to understand or perform test or parents refusal.