Kornimate/medical-research-clean huggingface dataset:
improving care of patients with heart failure

Conditions: Depression; Pain; Dyspnea; Quality of Life

Summary: heart failure (hf) affects more than 5 million americans and is a major source of morbidity and mortality. despite optimal management, over half of patients with hf suffer from pain, dyspnea, fatigue, and depression that diminish quality of life (qol). hf care also exacts a huge financial toll with yearly costs of $35 billion. although consensus guidelines call for providing palliative care (pc) to patients with hf to relieve suffering and improve qol, few receive it. the overall aim of this project is to conduct a randomized controlled trial (rct) to determine if an interdisciplinary pc intervention (symptom management service-hf \[sms-hf\]) provided concurrently with standard cardiology care improves symptoms, qol and satisfaction, and reduces resource utilization in outpatients with class ii-iv hf compared to standard cardiology care alone. subjects assigned to the sms-hf group will receive a 6-month interdisciplinary pc intervention based on the investigators successful sms model of outpatient pc for oncology patients and focused on assessment and management of physical, emotional, social, and spiritual distress and discussion of treatment preferences. innovations of this study are that it will rigorously assess the impact of the sms-hf on patient outcomes and on resource utilization, a key component to ensuring program sustainability. the investigators research team of pc and hf experts is recognized for its pc research and has a proven record of collaborating, conducting rcts of pc interventions, and studying outpatients with hf. the environment at ucsf is highly supportive of innovative research and of sustaining programs with demonstrated improvements in patient outcomes and operational effectiveness. the overall goal is to use the results from this study to support an application to the nih for a multi-center rct of the sms-hf and to study similar models of concurrent pc for patients with other serious illnesses.


Eligibility criteria:
* hf as primary dx or symptomatic/active hf * during index hospitalization or within the prior 6 months * age \> 18 * admit from: hospital, skilled nursing, home * medicine, cardiology, and heart failure services * co-morbidities can include end-stage renal disease, metastatic cancer, icu/ccu care patients if able to consent and complete survey * english speaking exclusion criteria: * non-english speaking * previous consult by palliative care service * pulmonary htn * right heart failure * lvad * pci or cabg patient within this admission * as with planned surgical intervention * pre/post heart transplant * pre/post organ transplant within this admission * dementia (unable to consent) * homeless * active drug user * hospice enrolled patient * geritracc patients * does not have a ucsf physician * lives outside of the sf bay area

Keywords: palliative care symptom management heart failure
the prefyx pps™ system eregistry

Conditions: Stress Urinary Incontinence

Summary: registry to gather information about the long term use of the prefyx pps system for the treatment of stress urinary incontinence (sui).

registry to gather information about the long term use of the prefyx pps system which utilizes a pre-pubic surgical approach (device is to be placed in front of the pubic bone) for the treatment of sui. no additional procedures are required beyond the physician's standard of care.

Eligibility criteria:
inclusion criteria: * patients presenting for treatment of female urinary stress incontinence (sui) exclusion criteria: * pregnant patients, patients with the potential for future growth or patients that are considering future pregnancies. * any patients with soft tissue pathology into which the implant is to be placed. * patients with any pathology which would compromise implant placement. * patients with any pathology, such as blood supply limitations or infections that would compromise healing.
impact of periodontal treatment on gastric helicobacter pylori eradication

Conditions: Helicobacter Pylori Infection

Summary: the efficacy of conventional systemic antibiotic therapy for eradication of gastric h. pylori has been seriously challenged by antibiotic resistance. identification of alternative therapeutic strategies might help to overcome the limitation. the investigators' aim was to examine the effect of adjunct periodontal therapy, on gastric h. pylori eradication rate.


Eligibility criteria:
inclusion criteria: * tested positive for h. pylori both in gastric biopsy specimens and dental plaque samples exclusion criteria: the patients who had treatment with following medications within 6 months before the clinical protocol: * had antibiotics * had proton pump inhibitor (ppi), * had h2 blockers, and * took bismuth derivatives * had previous eradication therapy, or * had previous periodontal therapy * edentulous patient * diabetic patients * pregnant patients

Keywords: periodontal treatment initial periodontal therapy h. pylori
effect of attention deficit hyperactivity disorder knowledge improvement program on male primary school teachers

Conditions: ADHD; Mental Disorder; Attention Deficit Hyperactivity Disorder

Summary: the study aims to assess the impact of implementing adhd knowledge improvement program on male primary school teachers' knowledge regarding adhd in abha city, saudi arabia.

primary school teachers play an essential role in early detection and proper treatment of school children suffering attention deficit hyperactivity disorder (adhd). there are indications that teachers may not have enough knowledge about this disorder. training programs can help to improve the knowledge of teachers about adhd.

Eligibility criteria:
inclusion criteria: * male teachers in governmental and private primary schools in abha city, saudi arabia. exclusion criteria: * those who have a similar training program before. * those who are not directly involved in the teaching process.

Keywords: saudi abha training adhd attention deficit hyperactivity disorder
the evaluation of free gingival graft operations around implant or teeth on quality of life

Conditions: Patient Reported Outcome

Summary: the purpose of this study is to evaluate the quality of life of patients who underwent fgg surgery around the natural tooth and as a second surgery after the implant operation, in comparison with general oral health assesment index(gohai).

thirty-two participants were included who were referred to the periodontology clinic suffering insufficient keratinized gingiva / mucosa deficiency around the implant and / or tooth/teeth. gohai-total and gohai psychological impact, functional limitation, pain and discomfort, behavioral impact subcategories were recorded at before and postoperative first week and 30th day. also, satisfaction questionnaires, number of painkillers and visual analog scale values were recorded.

Eligibility criteria:
inclusion criteria: * non-smoking * teeth and implants with keratinized gingiva width \<1 mm * a healthy periodontal and peri-implant condition * patients who didn't have ever experience periodontal surgery had first oral surgery experience with dental fgg operation for the first time * patients who underwent implant surgery for the first oral surgery experience * maximum two teeth/implants on recipient area exclusion criteria: * patients receiving any medication to disrupt wound healing * lactation or pregnancy * caries or defects on the tooth root surface * periapical lesion in the recipient area active periodontal disease * patients who have previously had periodontal or oral surgery experiences

Keywords: quality of life graft
a multi-centered trial evaluating the role of vitamin d metabolism in non-small cell lung cancer

Conditions: Non-Small Cell Lung Cancer

Summary: vitamin d exerts antiproliferative and differentiating effects in cancers, including non-small cell lung cancer (nsclc). the active form of vitamin d is 1,25, dihydroxycholecalciferol (calcitriol) which rapidly induces expression of cytochrome p450 24r-hydroxylase (cyp24a1). cyp24a1 initiates inactivation of calcitriol as a result of successive hydroxylation/oxidation reactions. this study seeks to prospectively determine the relationship between vitamin d gene expression and median survival as a primary outcome, and between the vitamin d receptor (vdr)/cyp24a1 gene expression and cancer stage, smoking status, serum 1,25 (oh)2d3 levels as well as cyp24a1 genotype.

this study seeks to prospectively determine the relationship between vitamin d gene expression and median survival as a primary outcome, and the relationships between the vitamin d receptor (vdr)/cyp24a1 gene expression and cancer stage, smoking status, serum 1,25 (oh)2d3 levels as well as cyp24a1 genotype. patients who are suspected to have lung cancer will be recruited to this study prior to their diagnostic biopsy. those who have consented to the study will give permission for blood and tissue from this biopsy to be analyzed for the study endpoints. statistical analysis on this data will seek to correlate cyp24a1 expression and medican survival of the participants. patients' data will be collected for smoking status and cancer stage. study enrollment to adequately power the study statistically is 80 patients. anticipated study duration is from 12 months to 18 months for sample collection and two years for follow-up for patient survival.

Eligibility criteria:
inclusion criteria: 1. scheduled for diagnostic bronchoscopy for suspected advanced stage lung cancer by ct/pet scanning. 2. tumor or lymph node accessible by transbronchial needle aspiration. 3. age 18-80. 4. all patients must be informed of the investigational nature of this study and must give written informed consent in accordance with institutional and federal guidelines. exclusion criteria: 1. unstable cardiovascular disease or other systemic disease 2. mental incompetence/active psychiatric illness 3. medical contraindication for bronchoscopy
the safety and efficacy of opc-64005 in the treatment of adult attention-deficit/hyperactivity disorder

Conditions: Adult Attention Deficit Hyperactivity Disorder

Summary: a trial to assess the safety and efficacy of opc-64005 in the treatment of adult attention-deficit/hyperactivity disorder.

a multicenter, randomized, double-blind, active- and placebo-controlled, parallel-design trial.

Eligibility criteria:
inclusion criteria (screening): * male and female participants 18 to 55 years of age, inclusive, at the time of informed consent. * participants with a primary diagnostic and statistical manual of mental disorders, 5th edition (dsm-5) diagnosis of adhd (including predominantly inattentive presentation, hyperactive presentation, and combined presentations) as confirmed by the adult adhd clinical diagnostic scale (acds) v 1.2. * participants willing to discontinue all prohibited psychotropic medication starting from the time of signing the informed consent and up to the 30 (+ 2)-day follow-up period. exclusion criteria: * participants with a history of inadequate response or suboptimal tolerability to atomoxetine. * participants who report allergies (lifetime treatment history) to stimulant or nonstimulant adhd medications. * participants with other dsm-5 disorders including psychosis (current or lifetime), bipolar disorder (current or lifetime), current major depressive disorder, or current panic disorder; or another psychiatric diagnosis that the investigator believes is primary or that will confound efficacy or safety assessments of the trail or interfere with participation in the trial otherwise. * participants with a clinically significant current dsm-5 diagnosis of borderline, antisocial, paranoid, schizoid, schizotypal, histrionic, narcissistic, avoidant, obsessive compulsive, or dependent personality disorders. * participants who currently have clinically significant dermatological, neurological, hepatic, renal, metabolic, hematological, immunological, cardiovascular, pulmonary, or gastrointestinal disorders such as any history of myocardial infarction, congestive heart failure, hiv (human immunodeficiency virus) seropositive status/acquired immunodeficiency syndrome, or active or chronic hepatitis b or c. * participants with a history of obstructive sleep apnea.

Keywords: adhd add
the utility of bedside lung ultrasonography on diagnosis of covid-19

Conditions: COVID; Pneumonia, Viral

Summary: novel coronavirus 2019 disease (covid-19) mortality is highly associated with viral pneumonia and its complications. accurate and prompt diagnosis shown to be effective to improve outcome by providing early treatment strategies. while chest x-ray (cxr) and computerized tomography (ct) are defined as gold standard, given the advantage of being an ionized radiation free, practical technique point of care ultrasound (pocus) is also reported as a diagnostic tool for covid-19. there are limited studies regarding the importance of pocus in diagnosis and review of covid-19. therefore the aim of this study is to evaluate the utility of bedside lung ultrasound on diagnosis of covid-19 for patients admitted to emergency department .

novel coronavirus 2019 disease (covid-19) mortality is highly associated with viral pneumonia and its complications. accurate and prompt diagnosis shown to be effective to improve outcome by providing early treatment strategies. while chest x-ray (cxr) and computerized tomography (ct) are defined as gold standard, given the advantage of being an ionized radiation free, practical technique point of care ultrasound (pocus) is also reported as a diagnostic tool for covid-19. there are limited studies regarding the importance of pocus in diagnosis and review of covid-19. therefore the aim of this study is to evaluate the utility of bedside lung ultrasound on diagnosis of covid-19 for patients admitted to emergency department .

Eligibility criteria:
inclusion criteria: * all patients with an informed consent * admission to emergency department with symptoms or signs of covid-19 exclusion criteria: * absence of informed consent * patients under age of 18 * presence of acute coronary syndrome * presence of chronic lung disease * pregnancy * presence of trauma * patients with a diagnosis of malignancy
covid-19 health messaging efficacy and its impact on public perception, anxiety, and behavior

Conditions: Public Health; Demography; Pandemics; Corona Virus Infection; News; Global Health; Perception

Summary: effective communication is a critical component of managing pandemic outbreaks like covid-19. this study explores covid-19 related public knowledge, perceptions, belief in public health recommendations, intent to comply with public health recommendations, trust in information sources and preferred information sources. participants are invited to include detailed free-text answers to make sure their covid-19 experiences are heard.

the survey is available online in 23 languages. free-text responses in native languages are highly encouraged. a robust global response will not only provide invaluable information to inform clinicians, healthcare institutions and governments about how to optimize the content and venue of covid-19 messaging, but will help write a story of covid in the words and languages of people from all over the world.

Eligibility criteria:
inclusion criteria: * 18 years of age exclusion criteria: * below 18 years of age

Keywords: penn state chime covid-19 messaging study
evaluation of the french translation of gothenburg trismus questionnaire (gtq)

Conditions: Trismus

Summary: a monocentric study to evaluate the french translation of gothenburg trismus questionnaire (gtq).

trismus is defined as a limitation in the mouth/jaw-opening ability due to a reduced mandible mobility. trismus can occur from benign jaw related conditions, often referred to as temporomandibular disorders (tmd). it can also result from local or metastatic tumor growth of head and neck (h\&n) tumors, and more importantly, as a debilitating side-effect to h\&n oncology treatment, especially radiotherapy the gothenburg trismus questionnaire (gtq) is a patient reported outcome, validated in english, portuguese and sweden language. the aim of this study is to develop a new tool in french language and to evaluate the specific impact of trismus on quality of life .

Eligibility criteria:
* inclusion criteria: * patient treated for trismus * age ≥ 18 years old * read, write and understand the french language * exclusion criteria: * patient under guardianship, deprived of liberty, safeguard of justice * refusal to participate in research

Keywords: trismus patient reported outcomes u gothenburg trismus questionnaire
extracellular vesicles and dysregulated coagulation in the prediction of stroke

Conditions: Stroke, Ischemic; Transient Ischemic Attack; Coagulation Disorder

Summary: annually 100,000 strokes occur, placing stroke as the largest cause of disability in the uk. 90% of strokes are preventable, leading to national focus on programmes including "the national stroke programme" to act on preventing, treating, and improving post-stroke care. importantly, over 25% of ischaemic stroke sufferers have previously had a transient ischaemic attack (tia), which presents the biggest concern for tia patients. there are no measures which reliably identify tia patients most likely to suffer a stroke. novel biomarkers for predicting stroke are key to addressing this problem. the predict-ev study aims to screen 300 tia patients and follow them over 12-months. the investigators will determine if a novel biomarker we've identified to increase thrombotic risk (endothelial derived extracellular vesicles) and the resulting increased prothrombin time is associated with patients at highest risk of stroke.


Eligibility criteria:
the inclusion criteria for phase 1 (initial patient recruitment) will be: 1. patients with or without diagnosis of tia made by a physician working in stroke medicine, sufficiently so to start post-tia care or so that no further investigation is thought necessary to confirm or refute the diagnosis. 2. tia confirmed patient has been prescribed antiplatelet drugs or anticoagulants. 3. patients must be aged \> 18 years. 4. patients are taking an ordinary diet by mouth. the inclusion criteria for phase 2 (patient representing with stroke) will be: 1. radiological evidence, on ct and/or mr imaging of the brain of cerebral infarction, with or without secondary haemorrhage. 2. the underlying mechanism of cerebral infarction is embolic from a cardiac source (e.g. atrial fibrillation), atherothromboembolic (from aorta or other large vessels in the neck) or in-situ thrombosis. no further investigations are thought necessary to confirm or refute the diagnosis. 3. no further investigations are thought necessary to confirm or refute the diagnosis. 4. patients must be aged \>18 years. 5. patients must not be pregnant or breast feeding. 6. patients are taking an ordinary diet by mouth. exclusion criteria the exclusion criteria for phase 1 (initial patient recruitment) will be: 1. inability to give consent. 2. inability to feed by mouth. 3. short life expectancy. 4. pregnancy or breastfeeding. 5. symptoms are readily explained by medical problems not involving focal cerebral ischaemia. the exclusion criteria for phase 2 (patient representing with stroke) will be: 1. patients who have not previously given consent for follow up blood sampling. 2. patients who are unable to feed by mouth. 3. patients in whom life expectancy is short. 4. patient is pregnant or breast feeding.

Keywords: stroke risk transient ischemic attack extracellular vesicles pro-thrombotic risk
gum arabic as immunomodulator in rheumatoid arthritis patients

Conditions: Rheumatoid Arthritis

Summary: gum arabic (ga) rich dietary fiber it is a water-soluble dietary fiber derived from the dried gummy exudates of the stems and branches of acacia senegal, ga found to have strong immuno modulator in vitro where it increased il10 production showing strong anti-inflammatory effects (19). the aim of this study is to determine the role of gum arabic in immunomodulation among patients with rheumatoid arthritis.

butyrate is short chain fatty acids representing the most important end product of colonic bacterial aerobic fermentation of gum arabic , it has a potent anti-inflammatory effect and can down regulates tnf a expression by modulating nf-kb-dna binding activity , in addition butyrate is known to act as histone deacetylase inhibitor in the cells.recently, in vitro and in vivo data indicates that hdac inhibitors may have anti-inflammatory effect due to their effects on cell death acting through acetylation of non-histone proteins. the possible anti-rheumatic mechanisms of hdac inhibitors, including growth arrest in rheumatoid arthritis synovial fibroblasts (rasfs), suppression of pro-inflammatory cytokines, suppressing angiogenesis as well as the protective effects on bone and cartilage against their destruction. the investigators expect regular intake of ga will raise serum butyrate level. the endogenous butyrate decreases the tnf level. the latter will decrease the number of relapsing episodes, arresting the destruction of joints and improve both survival and life quality of rheumatoid arthritis patients.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of rheumatoid arthritis 2. clinically stable as evidenced by medical history, complete physical examination 3. all medications and dosages are stable for 6 weeks before study entry, 4. non pregnant ladies. exclusion criteria: * 1- hepatic, cardiovascular, pulmonary, malignant, hematologic, neurologic, infectious, or inflammatory diseases unrelated to rheumatoid arthritis. 2-hospital admission within 4 weeks of start of the study. 3- uncontrolled hypertension 4- asthma or severe atopic disease;
the importance of physiotherapy after separation surgery in pygopagus conjoined twins

Conditions: Pygopagus Conjoined Twins; Separation Surgery; Pediatric Physiotherapy

Summary: motor function delays are observed in pygopagus conjoined twins due to limited movement experience and deficits in proprioceptive sense. this study aimed to evaluate the neuromotor development of conjoined twins who acquired independent bodies, lives, and movements as a result of separation surgery, and to examine the effect of postoperative physiotherapy intervention on gross motor function.

the study included two cases of pygopagus conjoined twins who applied for separation surgery at acıbadem altunizade hospital between 2021 and 2022. the twins were 9 months and 21 days old (a1-a2) and 23 months and 11 days old (b1-b2). after separation surgery, a conventional physiotherapy program was administered regularly for 3 months, 6 days a week, with two sessions per day, each lasting 45 minutes. the bayley-iii developmental screening test (dst) was used to evaluate neuromotor development, while the alberta infant motor scale (aims) and the gross motor function measure-88 (gmfm-88) were used to assess gross motor development. evaluations were performed preoperatively and at the 3rd postoperative month.

Eligibility criteria:
inclusion criteria: * having a diagnosis of pygopagus conjoined twins * having normal vital signs after separation surgery exclusion criteria: * having a diagnosis other than pygopagus conjoined twin * abnormal vital signs after separation surgery

Keywords: conjoined twins pygopagus physiotherapy gross motor development neurodevelopment