Kornimate/medical-research-clean huggingface dataset:
novel listeria vectors secreting gut flora-altering agents to prevent colon cancer and treat colitis

Conditions: Colon Cancer; Colitis

Summary: this is a simple tissue collection study with no therapeutic intent. colon tissues will be taken from standard of care procedures. tissues will be tested for their functions, expression of immune co-signaling molecules and reactions to transduction with recombinant listeria vectors to assess effects on expression of b7-h1 and cytokines.


Eligibility criteria:
inclusion criteria: * able to provide informed consent (or have consent provided through a guardian) * no immune-modulating drug use during study or within 30 days prior to enrollment * having colon material collected as part of standard of care exclusion criteria: * unable to provide informed consent (or have consent provided through a guardian) * not having colon material collected as part of standard of care

Keywords: tissue collection colonoscopic surgical procedures
hip denervation and intra-articular hydration in damaged hip in axial spondyloarthritis patients

Conditions: Patients With Axial SpA According to ASAS Criteria; Patients With Unilateral or Bilater Hip Damage According to BASRI Score; Age > 18

Summary: background: the hip joint is frequently affected in axial spondyloarthritis (spa) of adults with destructive effects in untreated patients. about 35% of axial spa patients had either unilateral or bilateral hip arthritis. destruction is more common with early-onset, active disease, or enthesitis. objectives: the aim of this study is to evaluate the effect of hip denervation (hd) and intra-articular hydration (iah) on pain, function score, hip mobility scores in a cohort of axial spa patients with grade 3 and 4 hip basri scores.


Eligibility criteria:
inclusion criteria: * age 18 or more * axial; spa fulfilled asa criteria * basri score grade 3 or 4 for one hip at least exclusion criteria: * patients younger than 18 * axial; spa with normal hip or hip involvement less than 3 on basri score
thin film spectacle coatings to reduce light sensitivity and headaches in patients with migraine

Conditions: Migraine Disorders; Photophobia

Summary: approximately 9% of men and 18% of women suffer from migraine headaches. almost all migraine sufferers report light sensitivity during a headache. some people with migraine report that light can trigger their migraines and some people with migraine are light sensitive all of the time. the investigators have recently determined that certain colors of light are more likely to trigger migraines than other colors. in this study the investigators want to know if people who wear glasses that block these colors of light will have fewer migraine headaches.


Eligibility criteria:
inclusion criteria: 1. must be diagnosed with migraine with aura or migraine without aura 2. must have chronic daily migraine (at least 15 headache days per month) 3. age 18 or older exclusion criteria: 1. currently wearing a spectacle tint specifically prescribed for migraine or light sensitivity 2. pregnant 3. unwilling or unable in the judgment of the investigator to complete the study 4. unavailable for any of the study visits 5. light sensitive conditions: meningitis, iritis, blepharospasm 6. degenerative diseases of the retina or optic nerve: diabetic retinopathy, ischemic optic neuropathy 7. medications known to affect retinal or optic nerve function: hydroxychloroquine, chloroquine, ethambutol, amiodarone, erectile dysfunction drugs 8. best corrected visual acuity less than 20/40 in either eye

Keywords: migraine with aura migraine without aura photophobia chronic daily headache
supplement intake in infertile men;the effect on sperm parameters,fertilization rate and embryo quality

Conditions: Oligospermia

Summary: the vitamin,minerals and amino acid supplementation for 3 months will improve the semen parameters,fertilization rate and embryo quality in subfertile men undergoing ivf treatment

with the supplement intake containing amino acids, vitamins and minerals designed to improve sperm parameters, the couples undergoing ivf treatment will benefit as the change and improvement of sperm parameters will increase the fertilization rate and improve the embryo quality thus allowing shorter time for pregnancy achievement and less frustration with long duration of treatments

Eligibility criteria:
inclusion criteria: * healthy male age 20-50 * at least one ivf cycle without pregnancy * sperm parameters: * oligospermia 5-20\*106 * teratospermia 6-14% normal forms * asthenospermia \<30% motility exclusion criteria: * female factor infertility * age \> 50 or under 20 * testicular problem on physical examination * history of malignancy and /or chemotherapy * usage of antiandrogen/testosterone * history of drug abuse/alcohol * a known endocrinological problem * current std or genitourinary infection * retrograde ejaculation * y chromosome microdeletion * karyotype abnormalities
serotonin, anxiety and visceral sensation

Conditions: Healthy

Summary: the goal of this crossover study was to learn about the potential regulatory role of serotonin in interoceptive processing and its relationship to levels of state anxiety. this experiment directly compared the impact of a selective serotonin reuptake inhibitor (ssri) (20mg citalopram) to that of a placebo on the neural processing of ordinary interoceptive sensations and the relationship of these influences to anxious states. healthy young volunteers completed the visceral interoceptive attention task with each treatment condition (citalopram and placebo). the task involves focusing attention on heart, stomach, or visual sensation control while scanned with functional magnetic resonance imaging (fmri). the difference in haemodynamic response between interoceptive sensation(s) and visual sensation (i.e. the relative interoceptive response) is compared between treatment conditions. state anxiety is measured at each test period. it is used to test for a moderating effect of state anxiety on the influence of serotonin in interoceptive processing and used post-hoc to explore associations between changes in state anxiety and changes of interoceptive relative interoceptive response due to the ssri.


Eligibility criteria:
inclusion criteria: - healthy volunteer exclusion criteria included: * the presence of significant ongoing medical condition; * pregnancy or breastfeeding; * currently taking any medication (excluding contraceptive pill); * first-degree family history of bipolar disorder; * an indication of current or historical mental health disorder, * mri scanner contraindications (e.g. metallic implants) * data that is unanalyzable due to movement * excessive side effects of the drug (e.g. nausea)

Keywords: serotonin interoception ssri anxiety
reverse shoulder replacement: age 60 or younger outcomes

Conditions: Shoulder Arthritis

Summary: the purpose of this study is to assess the early outcomes following reverse shoulder arthroplasty (rsa) in patients sixty years or younger for the purpose of characterizing these patients, evaluating their clinical outcomes and radiographic appearance.the investigators would like to know how quickly they are healing and returning to their baseline activities of daily living and ability to work. this will help when counseling patients prior to surgery as it will give us a better defined and study supported understanding of the post-operative recovery timeline in the younger population.

this study is looking at patients who are sixty years or younger at the time of they undergo a reverse total shoulder replacement. this is an important population to look at their functional and clinical outcomes as they are often still employed and have more physical demands upon their shoulder in everyday life than the older replacement population for which there are more outcome data available. the investigators would like to determine how the younger population is healing and returning to their baseline activities of daily living and ability to work. this will help when counseling patients prior to surgery as it will give us a study supported understanding of the post-operative recovery timeline in the younger population. the investigators will review x-rays to evaluate healing at two years. functional surveys are given pre and post operatively (1 \& 2 years) and these will be reviewed as well. a physical exam is also performed to determine range of motion pre and post operatively (1 \& 2 years).

Eligibility criteria:
inclusion criteria: * 60 years old or younger at the time of surgery * reverse shoulder arthroplasty with a single implant system by one of our four surgeons exclusion criteria: * minors * unable to complete imaging portion of the two-year follow-up due to health safety/exposure concerns * unwilling/unable to return for follow up * revision procedure

Keywords: reverse total shoulder arthroplasty 60 years old or younger outcomes
rna-loaded dendritic cell cancer vaccine

Conditions: Renal Cell Carcinoma

Summary: the purpose of this trial is to examine the safety, feasibility, immunological response, and clinical antitumor activity of administering a dendritic cell vaccine to patients with metastatic renal cell carcinoma.


Eligibility criteria:
inclusion criteria: * have a new diagnosis of metastatic renal cell carcinoma; * must be at least 18 years or older; * have a scheduled unilateral nephrectomy; * ecog of 0 or 1; * free of brain metastases by ct or mri; * normal renal function in contralateral kidney; * male or non-pregnant/non-lactating female on appropriate birth control methods while on study; * clinically acceptable screening results. * no immunosuppressive therapy not limited to corticosteroids (including topical steroids or steroid containing inhalers), azathioprine cyclosporine two months prior to study entry; * no active autoimmune disease

Keywords: kidney cancer renal cancer
hearing improvement after making a hole surgically in eardrum with or without ventilation tube in children with glue ears

Conditions: Otitis Media With Effusion in Children; Hearing Loss

Summary: the goal of this clinical trial is to compare the effectiveness of myringotomy with ventilation tube insertion to myringotomy alone in improving hearing in children with glue ear. the main question it aims to answer is: does adding a ventilation tube to myringotomy lead to greater improvement in hearing compared to myringotomy alone? researchers will compare these two surgical techniques to determine which offers better outcomes for children with otitis media with effusion. the participants will: 1. have their hearing evaluated before surgery 2. undergo either myringotomy with ventilation tube insertion or myringotomy alone 3. have their hearing evaluated at follow-up visits at 2 weeks, 1 month, and 3 months post-operatively


Eligibility criteria:
inclusion criteria: * cases of otitis media with effusion * more than 20 decibel (db) conductive hearing loss on pure tone audiometry * non-responder to medical treatment after three months of medical treatment exclusion criteria: * children having recurrent otitis media * discharging ears * history of bleeding disorder

Keywords: otitis media with effusion hearing loss children middle ear ventilation
examining engagement trends among participants in peripheral neuropathy clinical research

Conditions: Peripheral Neuropathy

Summary: this trial aims to uncover the factors driving patient decisions regarding enrollment, withdrawal, or re-engagement in peripheral neuropathy clinical trials. understanding these factors will significantly improve the relevance and effectiveness of future research endeavors. ultimately, this trial endeavors to deepen our understanding of the factors impacting peripheral neuropathy clinical trial participation. enhancing participation rates could accelerate the development of innovative treatments for this debilitating condition.


Eligibility criteria:
inclusion criteria: * aged ≥ 18 years old * diagnosis of peripheral neuropathy * able to comprehend the investigational nature of the protocol and provide informed consent exclusion criteria: * female patients who are currently pregnant or nursing * inability to perform regular electronic reporting * has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial

Keywords: peripheral neuropathy
online psychoeducation for intolerance of uncertainty

Conditions: Intolerance of Uncertainty; Anxiety

Summary: randomized control trial examining the efficacy of an online intolerance of uncertainty focused psychoeducation intervention.

randomized control trial examining the efficacy of an online intolerance of uncertainty (iu) focused psychoeducation intervention among females elevated in iu.

Eligibility criteria:
inclusion criteria: * elevated intolerance of uncertainty at baseline exclusion criteria: * patients would be excluded if they endorsed suicidal ideation/intent that required hospitalization.

Keywords: intolerance of uncertainty anxiety
comprehensive monitoring of men with prostate cancer cared for by "active surveillance

Conditions: Prostate Cancer

Summary: prostate cancer is the most commonly diagnosed cancer in men. however, there is a wide range in prognosis determined by a host of factors. this study will evaluate the feasibility of guiding therapeutic intervention electronically facilitated symptom and disease monitoring in patients being followed on active surveillance. additionally, we will develop a tissue and data resource to support discovery and hypothesis generation to evaluate germline and/or somatic alterations in relation to cancer-specific and overall outcomes..

primary objectives: 1. monitor cancer-specific outcomes of men who meet consensus criteria for active surveillance under one of three categories: 1) low or very low-risk prostate cancer, 2) intermediate risk with patient consent, or 3) severe medical comorbidities and high-risk localized prostate cancer or patient desire, despite recommendation secondary objectives: 1. screen for a relationship between cancer-specific and clinical outcomes related to selected comorbidities. 2. determine the feasibility of electronically facilitated symptoms and disease monitoring to guide therapeutic intervention and prompt therapeutic course correction. 3. develop a tissue and data resource to support discovery and hypothesis generation focused on germline alterations, somatic alterations, and/or the interaction between the two in determining cancer-specific and overall outcomes

Eligibility criteria:
inclusion criteria: 1. patients will have histologic diagnosis of adenocarcinoma of the prostate within 24 months of study entry. 2. patient must meet at least one of the following clinical indications for as: national comprehensive cancer network (nccn) very low risk or low risk prostate cancer meeting consensus guidelines for as; nccn intermediate-risk prostate cancer requesting as (per patient and clinician shared decision making); or have severe medical comorbidities (defined as cci estimated 10-year survival \< 50% and agreed by treating clinician) with high- or very high-risk localized prostate cancer. 3. patients must agree to comply with the surveillance schedule. 4. patients must be over 18 years of age 5. written informed consent 6. patients must be fluent in the english language to participate in the patient report outcome and symptoms monitoring portion of the trial. exclusion criteria: 1. patients are ineligible if they choose not to share their medical data for research purposes. 2. prior radiation therapy for treatment of the primary tumor. 3. planned concomitant hormonal therapy, chemotherapy, or radiation therapy while on protocol
efficacy and safety of oral bosentan on healing/prevention of digital (finger) ulcers in patients with scleroderma

Conditions: Digital Ulcers; Systemic Sclerosis

Summary: in an earlier clinical trial, rapids-1, conducted in scleroderma patients with or without digital ulcers at baseline, bosentan significantly reduced the number of new digital ulcers versus placebo. the purpose of the present trial (rapids-2) is to evaluate the prevention and healing effects of bosentan versus placebo on digital ulcers over a 24-week treatment period.


Eligibility criteria:
main inclusion criteria: * systemic sclerosis (ssc), diffuse or limited. * ssc patients with at least one digital ulcer at baseline qualifying as a cardinal ulcer. main exclusion criteria: * digital ulcers due to conditions other than ssc. * severe pulmonary arterial hypertension (pah) (who class iii and iv). * malabsorption or any severe organ failure (e.g., lung, kidney, liver) or any life-threatening condition. * treatment with parenteral prostanoids (prostaglandin e, epoprostenol, or prostacyclin analogs) during the past 3 months prior to randomization. * treatment with inhaled or oral prostanoids one month prior to randomization. * previous treatment with bosentan.

Keywords: scleroderma finger ulcers digital ulcers systemic sclerosis
pain perception of children and youth receiving non-sedated botulinum toxin-a injections using the buzzy®

Conditions: Pain

Summary: the use of botulinum toxin injections (bont-a) has become a standard therapy for children and youth who suffer from stiffness of their muscles due to a neurological problem. these injections are given into each muscles which require treatment, which often means receiving multiple injections in one session. intramuscular injections are typically painful. treatment can be provided unsedated and then should incorporate distraction and relaxation techniques, or can be alternatively be provided with the use of sedation. to improve the pain experience the investigators want to assess the feasibility and impact on the pain perception when using a vibration device called the buzzy during bont-a injections. the buzzy creates a vibration that is applied over the injection site for 30 seconds before the injection and will be continued just above the injection site during the injection. the buzzy has been shown to help reduce pain in procedures such as i.v. insertions and immunizations, but has not been tested in children and youth receiving multiple bont-a injections.

children and youth who receive hypertonia treatment with non-sedated bont-a injection will be invited to participate in this clinical trial. the patients will be randomized to receiving the injection with the buzzy versus the control group without the buzzy. both groups will still receive their typical supports that will include their choice of local anesthetic cream, relaxation and distraction techniques. randomization will be stratified for the ability to self report. measures to capture the pain will include self report of pain, by using the face pain scale revised (fpsr) in all participants who are able to self report. in addition all participants will be evaluated by the use of the face, legs, activity, cry and consolability scale (flacc scale), an observational tool validated to capture pain responses. the investigators will also include measurement of heart rate at rest, during and after the intervention.

Eligibility criteria:
inclusion criteria: * any child and youth who receives non-sedated botulinum toxin-a injections and is interested and consenting to using the buzzy exclusion criteria: * patients receiving botulinum toxin-a injections under sedation * patients younger than 2 years or older than 18 years.

Keywords: pain, pediatrics, botulinum toxin injections, buzzy
validity and reliability of the turkish version of performance measure for activities of daily living-8

Conditions: Congestive Heart Failure

Summary: chronic heart failure (chf) is characterized by limited exercise performance, which is mainly determined by disease-specific factors, such as diminished cardiac output, abnormal ventilatory response, and low perfusion in skeletal muscles, which lead to skeletal muscle dysfunction.1 exercise intolerance and symptoms may lead to activity restriction and further functional deterioration with the progression of chf. there is some evidence that disease-specific self-report measures more quantify clinically relevant domains than measures of general health status and are generally more sensitive to clinical change. aim of the study is to investigate the validity and reliability of the pmadl-8 questionnaire in the turkish population.

chronic heart failure (chf) is characterized by limited exercise performance, which is mainly determined by disease-specifi factors, such as diminished cardiac output, abnormal ventilatory response, and low perfusion in skeletal muscles, which lead to skeletal muscle dysfunction.exercise intolerance and symptoms may lead to activity restriction and further functional deterioration with the progression of chf. there is some evidence that disease-specific self-report measures more quantify clinically relevant domains than measures of general health status and are generally more sensitive to clinical change. aim of the study is to investigate the validity and reliability of the pmadl-8 questionnaire in the turkish population.

Eligibility criteria:
inclusion criteria: * patients aged between 45-75 years, who are conscious, able to answer all questions, can communicate in turkish, diagnosed with chf, have nyha (new york heart association) heart failure functional classification ii and iii and agree to participate in the study will be included in the study. exclusion criteria: * chf patients with nyha functional class iv who were hospitalized, who are unable to cooperate, and not willing to participate.

Keywords: congestive heart failure functional limitation questionnaire
effect of omega-3 supplementation on serum level and gene expression of igf-1and igfbp-3 in men with cvd.

Conditions: Cardiovascular Disease

Summary: the aim of this study is the comparison between the effects of supplementation with omega 3 or placebo for 8 weeks in serum level of igf-1 and igfbp-3 and gene expression of igf-1 in patients with cardiovascular disease.


Eligibility criteria:
inclusion criteria: * cvd patients 45- 65 years old, patients with ≥ 50% stenosis in at least one coronary angiogram demonstrated, body mass index in the range 18.5- 35, avoidance of dietary supplements, vitamins and herbal products at least 3 months before and throughout the intervention, willingness to participation, exclusion criteria: * people who have used omega 3 supplements in last 3 months, having chronic renal disease , gi disease, hepatobiliary diseases, hematological disorders, hypo- or hyperthyroidism, smokers

Keywords: atherosclerotic igf-1 igfbp-3