Kornimate/medical-research-clean huggingface dataset:
inflammatory genomics in human carotid artery disease

Conditions: Cardiovascular Diseases; Atherosclerosis; Carotid Artery Diseases; Inflammation

Summary: to investigate the relationship between genetic variation in genes for inflammation and carotid artery atherosclerosis.

background: atherosclerotic vascular disease is a major source of morbidity and mortality. inflammation plays an important role in atherosclerosis. the tools to systematically study the extent to which genetic variation determines risk of and progression of atherosclerosis are only now becoming available. design narrative: the study will evaluate the role of genetic variation in inflammatory pathway genes at 29 loci on the risk and progression of carotid artery atherosclerotic disease (caad). genes to be evaluated include those potentially involved in plaque initiation and progression. the investigators will evaluate single nucleotide polymorphisms (snps) informative for the common locus haplotypes. choice of informative polymorphisms for evaluation is based on the genes' evolutionary history. they will evaluate progression effects in subjects with caad followed longitudinally by noninvasive magnetic resonance (mr) techniques over 3 years. risk will be evaluated by case-control comparisons. in additions to evaluating genetic polymorphisms, they will evaluate the intervening phenotypes of protein level for fibrinogen, c-reactive protein, serum amyloid a, and interleukin-6. independence of genetic predictors from traditional cardiovascular risk factors will be evaluated. the major specific aims are: aim 1. test for inflammatory genetic effects and protein level in caad progression in 550 subjects with caad (275 with 15-49% and 275 with 50-79% baseline caad stenosis) evaluated by 3-year magnetic resonance image follow-up of percent lumen stenosis; aim 2. determine whether the variation in the inflammatory genes or protein levels predicts 810 case vs. 810 control status with a case distribution of 335 subject with 15-49%, 275 with 50-75% and 200 with \>80% carotid artery stenosis at baseline. age (onset of vascular disease for cases, current age for controls)-, sex-, race-, and hospital-matched controls will have less than 15% stenosis on carotid duplex ultrasound. genes that are implicated in disease may eventually allow targeted therapy.

Eligibility criteria:
no eligibility criteria
characterize the links between sleep, emotional dysregulation and learning in neurodevelopmental disorders.

Conditions: Attention Deficit Disorder With or Without Hyperactivity (ADHD); Autism Spectrum Disorder (ASD)

Summary: the aim of this protocol is to disentangle the links between symptoms of emotion dysregulation, sleep disorders and cognitive deficits by measuring the effects of an emotional induction task on childrens' sleep with autism spectrum disorders (asd) and attention deficit hyperactivity disorder (adhd).


Eligibility criteria:
inclusion criteria: * subjects aged 7 to 12 * able to receive clear, age-appropriate information and to participate fully in the study * whose legal representative(s) are able to understand the objectives and risks of the research and to give their dated and signed informed consent. * subjects benefiting from a social health insurance plan (beneficiary of the legal representative(s)) * with a diagnosis made prior to inclusion of autism spectrum disorder (asd) or attention deficit disorder with or without hyperactivity (adhd) as defined by diagnostic and statistical manual 5 (dsm-5). * with abbreviated intelligence quotient \> 80 measured by wechsler intelligence scale for children version iv (wisc-iv )no more than 6 months prior to research inclusion * no diagnosis of: fragile x syndrome, rett syndrome, trisomy 21, tuberous sclerosis of bourneville, von recklinghausen disease, cytomegalovirus encephalitis (cmv encephalitis), congenital rubella, phenylketonuria * no clinically significant abnormality which, in the investigator's opinion, could interfere with the implementation of the study. exclusion criteria: - current or past neurological problem(s) (e.g. stroke, epilepsy, meningitis, head trauma with loss of consciousness of more than 15 min, concussion, brain tumor, ...). tumor, ...) * transmeridian travel (\> 2 time zones) in the month prior to study inclusion * presence of a mood disorder (bipolar disorder or depression) according to dsm-5 criteria * social jet-lag \> 2 hours (mid-point of sleep differential during weekends vs. weekdays) * modification of psychotropic medication in the 2 months prior to inclusion * use of melatonin-based dietary supplement(s)/medication(s) in the 24 hours prior to study inclusion * use of psychostimulant(s) within 48 hours of study entry * extreme chronotype (morningness/eveningness questionnaire score \ 42) * cognitive-behavioral therapies (cbt) targeting sleep disorders * participation in research involving an experimental drug which may interfere with the protocol\*. * minor under guardianship * subject in a period of exclusion (determined by a previous or current study) * subject in emergency situation
patient satisfaction with initial phone call versus office visit following minimally invasive hysterectomy, a randomized controlled trial.

Conditions: Abnormal Uterine Bleeding

Summary: patients will be randomized to clinic or telephone follow up after outpatient tlh. surveys will document patient satisfaction.

this is a randomized controlled trial looking at patient satisfaction with a 1-2 week postoperative visit versus phone call after minimally invasive hysterectomy. patients will be screened, enrolled, consented, and randomized during the preoperative office encounter, which usually takes place 30 days prior to their scheduled surgery. patients randomized to the study group (1-2 week postoperative phone call) will be given a time and date when to expect the postoperative phone call. patients randomized to the control arm will receive a standard postoperative visit appointment 7-21 days after surgery. patients in both arms will receive postoperative discharge instructions advising when to contact our office and when to present to the emergency room with certain complaints. the patients in the study arm will have instructions reinforcing that they will be contacted with a postoperative phone call instead of a visit initially; however, patients in both arms will have a postoperative visit 6-8 weeks following surgery. after surgery, patients randomized to the study arm will receive the phone call at 7-14 days post-op. the physician performing the phone call will be a minimally invasive gynecology fellow in our practice. the provider will use a script to review all of the typical review of systems and pertinent postoperative functioning questions typically reviewed and documented in our postoperative visit. they will also review the surgical pathology at this time. this conversation will be documented in our electronic medical record. patients randomized to the control arm will undergo typical office visit at 7-21 days postop. patients in both arms will have postoperative office visits at 6-8 weeks postop, and will complete a survey at that time. the survey is a modified version of the scahps survey to assess patient satisfaction with the surgical experience. there will also be some questions about the patients' attitudes towards the number and timing of postoperative visits.

Eligibility criteria:
inclusion criteria: * women undergoing minimally invasive hysterectomy exclusion criteria: * patients without adequate phone or transportation access * patients with concern for underlying malignancy

Keywords: patient satisfaction, hysterectomy, follow up
veterans living with hiv/aids: a pilot study examining risk factors associated with self-directed violence

Conditions: Human Immunodeficiency Virus Infection(HIV)/Acquired Immunodeficiency Syndrome (AIDS); Self-Directed Violence

Summary: the purpose of this project is to gather pilot data related to risk factors associated with suicide in veterans with human immunodeficiency virus (hiv)/ acquired immune deficiency syndrome (aids) and to develop an educational and interventional tool and instructional guide that can be utilized by local and national providers to increase understanding regarding suicide risk assessment. there are no hypotheses associated with this qualitative pilot study.

to achieve these goals, a semi-structured interview will be conducted to gather this qualitative information. specifically, this study aims to gather the following information from veterans with hiv/aids: a) information regarding disease acquisition; b) psychosocial stressors; c) social supports; d) protective factors; and e) previous suicidal ideation and behaviors. further, additional exploratory questions will be asked regarding proposed modifications to the suicide risk assessment guide pocket card, an existing va tool, so that it can be modified for use by local and national hiv/aids providers.

Eligibility criteria:
inclusion criteria: * between ages 18 to 90 * have a diagnosis of hiv/aids * currently receiving hiv/aids treatment * currently receiving or eligible to receive physical and/or mental health care through the va eastern colorado health care system exclusion criteria: * psychosis at time of interview as determined by observation and/or interview. * intoxication via alcohol or other illicit drugs at time of assessment as determined by observation and/or interview.

Keywords: veterans human immunodeficiency virus infection(hiv)/acquired immunodeficiency syndrome (aids) self-directed violence
implementation of cpt for ptsd in diverse communities

Conditions: Stress Disorders, Post-Traumatic

Summary: aim: to identify, assess, and address organizational context and provider-level barriers and facilitators of implementation of evidence-based treatments (ebts) using a mixed-methods approach in a diverse community mental health center (cmhc), massachusetts general hospital chelsea health clinic (mgh chelsea). hypothesis: anticipated barriers may include, but are not limited to, organizational climate, heavy case-loads, community mental health workers (cmhw) beliefs about ebts, and provider motivation to learn ebt.


Eligibility criteria:
inclusion criteria: * be over 18 years of age * speak english * be employed at least part time at mgh * willing to have focus group/interview audiotaped and transcribed for data analysis exclusion criteria: * inability to meet the above inclusion criteria

Keywords: ptsd ebt est community latino
serial measurement of serum antimullerian hormone in women undergoing laparoscopic cystectomy of endometrioma

Conditions: Endometriosis

Summary: the purpose of this trial is to study ovarian reserve after laparoscopic endometrioma cystectomy by measuring antimullerian hormone. the measurements were measured before the surgery and one week and three months after the surgery.

antimullerian hormone will be obtained in patients with ovarian endometrioma before laparoscopic cystectomy is done. the measurements were compared with antimullerian hormone after one week and three months after the surgery. forty three patients will be included in this study.

Eligibility criteria:
inclusion criteria: * 20-40 years * ovarian endometrioma \> or = 3 cms * laparoscopic cystectomy treatment exclusion criteria: * previous ovarian surgery * other ovarian pathology * previous drugs or hormonal treatment for endometrioma

Keywords: endometriosis endometrioma antimullerian hormone cystectomy
multicentre retrospective study of treatment and outcomes in stemi patients in fujian province

Conditions: ST-segment Elevation Myocardial Infarction

Summary: this is a multicentre observational study planned to gather follow up data for a period of 1 year in order to understand the treatments and outcomes of st-segment elevation myocardial infarction(stemi) and improve medical care quality in fujian province for china. consecutive patients who were admitted and diagnosed with stemi between january 2014 december 2018 were conducted at five regional representative hospitals in fujian province, which included the fujian provincial hospital,longyan first hospital, the affiliated hospital of putian university,the second affiliated hospital of fujian medical university and mindong hospital of ningde city.


Eligibility criteria:
inclusion criteria: * stemi patients with symptom onset within 30 days exclusion criteria: -
study of pbk_l1704 for the treatment of moderate to severe acute pain after bunionectomy in south korea

Conditions: Acute Pain

Summary: the primary objective is to evaluate the analgesic efficacy of pbk_l1704 compared with placebo in patients with moderate to severe acute pain after bunionectomy.


Eligibility criteria:
inclusion criteria: * scheduled to undergo primary, unilateral, first metatarsal bunionectomy with osteotomy and internal fixation * able to understand and comply with the study procedures and requirements, and able to provide written informed consent before any study procedure. exclusion criteria: * participated in another oliceridine clinical study. * received any investigational drug, device or therapy within 35 days before surgery. * clinically significant medical, surgical, postsurgical, psychiatric or substance abuse condition or history of such condition that could confound the interpretation of efficacy, safety or tolerability data in the study. * american society of anesthesiologists (asa) physical status classification system classification iii or worse.
yspsl for prevention of delayed graft function part b

Conditions: Kidney Diseases

Summary: selectins have been implicated in the pathogenesis of ischemia/reperfusion (i/r)-induced kidney injury and resultant delayed graft function (dgf). psgl-1 is a ligand for p-, e-, and l-selectin. it has been reported that yspsl (rpsgl-ig) blocks p-selectin and, to a lesser degree, e- and l-selectin. both spsgl-1 and yspsl (rpsgl-ig) have been shown in animal models to reduce both cytokines and tissue damage associated with ischemia reperfusion and to improve renal function post-transplant. therefore, the current phase i/ii clinical study is designed to assess the safety and efficacy of yspsl (rpsgl-ig) in preventing dgf in patients undergoing cadaveric kidney transplants and to determine a dose for future pivotal studies.

this will be a multicenter, single-dose, dose-escalation study. the study will be in 2 parts: the first, part a, will be an open label evaluation of single doses of four dose cohorts; the second, part b will be a randomized, double-blind, placebo-controlled, single-dose study of two dose cohorts. patients who are undergoing cadaveric kidney transplantation and are at risk for development of dgf, based upon known risk factors, will be eligible to participate in the study. a maximum of 24 patients will be enrolled in part a. 60 patients will be enrolled in part b.

Eligibility criteria:
inclusion criteria: * patients undergoing primary cadaver renal transplants exclusion criteria: * patient has a planned transplant of a donor kidney from a non-heart beating donor * patient has a planned transplant of kidneys that are implanted en bloc (dual kidney transplant) or from donors \< 6 years of age * patient has a planned transplant of a kidney from a donor who has received investigational therapies designed to reduce the impact of ischemia/reperfusion (i/r) injury, dgf, or other donor-related immune events * patient is planned to receive a living donor kidney; or patient is planned to receive an abo-incompatible donor kidney

Keywords: delayed graft function
molecular mechanism of trophinin in cancer invasion and metastasis

Conditions: Lung Cancer

Summary: our study established a model combine the in silico biology and empirical methods to identify clinically useful biomarker from information of microarray gene expression profiles in public domain. through this method, we found trophinin as a novel prognostic marker for early stage lung cancer, which provide insight towards the process of cancer metastasis and the potential target for treatment.

this study was to combine the in silico biology and empirical methods to identify clinically useful biomarker of lung cancer from microarray gene expression profiles in public database. using the expression profile of a known metastasis suppressor, crmp-1, as a template to search for and compare transcriptome expressions in publicly accessible microarray datasets, trophinin (tro) was identified as the best correlated gene. the expression pattern of trophinin in a lung cancer cell lines of invasion model was investigated using quantitative rt-pcr. the role of trophinin in cancer metastasis was investigated by measuring the change of invasion activity in trophinin gene-transfected cell lines. the relationship of trophinin and the clinicopathological characteristics of lung cancer were further examined by immunohistochemical staining.

Eligibility criteria:
inclusion criteria: * patients who underwent surgery for non-small-cell lung cancer at the national taiwan university hospital from 1991 to 2000 with available stored tissue blocks were included as potential subjects in this study. exclusion criteria: -

Keywords: metastasis, survival, malignancy, female, trophinin
clinical study of lung-benefiting moxibustion reduce exacerbations of asthma

Conditions: Asthma

Summary: for patients with poor asthma control, on the basis of treatment guided by gina guidelines, lung-benefiting moxibustion treatment will be given, and it will be applied 10 days before "early onset", once every 10 days, and the follow-up was 45 weeks, 1 cycle per year, for 2 consecutive cycles (2 years). the annual number of flare-up of asthma patients will be used as the main outcome index to evaluate the clinical effect of lung-benefiting moxibustion on reducing exacerbations of asthma. by observing immunoglobulin, t cell subsets and other indicators, the advantage population and mechanism of moxibustion in treating patients with poor asthma control will be clarified.


Eligibility criteria:
inclusion criteria: * patients who meet the diagnosis of asthma (remission); * patients with poor clinical control; * age 18-80 years old; * voluntarily undergo treatment and sign an informed consent form; exclusion criteria: * patients combined with pulmonary abscess, pulmonary fibrosis, active pulmonary tuberculosis, bronchiectasis or other lung diseases; * patients with severe cardiovascular and cerebrovascular diseases (malignant arrhythmia, unstable angina pectoris, acute myocardial infarction, cardiac functional classification≥iii, stroke, cerebral hemorrhage, etc.)； * patients with severe liver diseases (liver cirrhosis, portal hypertension, bleeding due to esophageal and gastric varices, etc.) or severe kidney diseases (renal dialysis, kidney transplantation, etc.)； * patients with confusion, various mental disorders, etc., who are unable to communicate normally; * pregnant and lactating women; * patients with heat phlegm pattern through tcm pattern differentiation； * patients participating in other clinical trials within 1 month prior to enrollment; * received tcm external treatment such as lung-benefiting moxibustion for 1 year; * patients allergic to moxibustion drugs, smoke, etc.

Keywords: asthma out of control lung-benefiting moxibustion treating winter diseases in summer rct
nutritious fruits and veggies to improve health: a culinary medicine intervention

Conditions: Cancer, Nos

Summary: this study includes a 12-week culinary medicine intervention integrated within the existing ymca suncoast survivorship and wellness program powered by moffitt. members of the john geigle ymca will be assigned to the nourish intervention, which includes biweekly provision of fruit and vegetable bundles, recipe cards, and nutritional education handouts plus 30-minute culinary medicine demonstrations with skill-building training (six total demonstrations focused on fruit and vegetable recipes).


Eligibility criteria:
inclusion criteria: * diagnosed with cancer. * able to speak and read english. * without documented or observable psychiatric or neurologic diagnoses that could interfere with participation (e.g., dementia, active psychosis). * able to provide informed consent. exclusion criteria: * not meeting all of the above inclusion criteria.
using affectionate communication as a response to acute stress

Conditions: Stress

Summary: this study will examine the effects of tending to significant social relationships on managing and reducing stress.

stress is a large part of daily modern life; however, it can cause a number of long-term problems for mental and physical health. recent research has confirmed that there are definite mental and physical health benefits of maintaining significant positive social bonds. many of these benefits appear to be associated with the ability to regulate stress that is caused by environmental challenges. drawing on close relationships and expressing affection may help people to recover from stress more effectively. this study will evaluate the tend-and-befriend theory, which suggests that engaging in behaviors aimed at maintaining and strengthening significant social bonds can act as an adaptive response to acute stress. all participants in this study will undergo a series of standard laboratory stressors designed to elevate cortisol levels. cortisol, also known as the "stress hormone," is activated and secreted within the body in response to stress. current research suggests that displaying signs of affection toward a loved one can lower cortisol levels, causing the body to relax and recover from a stressful situation more quickly. after lab tests have been completed, participants will be randomly assigned to an experimental or control group. participants assigned to the experimental group will spend 20 minutes writing an affectionate letter to a loved one. participants assigned to the control group will spend 20 minutes writing about meaningless topics. levels of cortisol will be measured using saliva samples from each participant during the writing session. levels of oxytocin, a hormone known to transmit signals within the brain and often associated with bonding and building trusting relationships, will be measured from blood samples taken during the writing session as well. participants will also provide a self-report of their current stress level at the end of the study. participation in this study will last approximately 2 hours. by examining associations between the communication of affection and responses to acute stress, this study may eventually lead to the development of new and better treatment options for people with constant acute stress.

Eligibility criteria:
inclusion criteria: * english-speaking * weigh at least 110 pounds * moderate to no anxiety about having blood drawn exclusion criteria: * hypertension or diabetes * current or recent pregnancy * colorblindness * history of cancer * current use of alpha blockers, beta blockers, or steroids

Keywords: emotion oxytocin cortisol