Kornimate/medical-research-clean huggingface dataset:
effect of probiotic strain lactobacillus paracasei ps23 on brain fog in people with long covid

Conditions: Long COVID; Brain Fog; Cognitive Change

Summary: the goal of this clinical trial is to test whether the intervention of probiotics supplement can improve symptoms of long covid syndrome. participants will be given probiotics or placebo capsules for two month. symptom questionnaires, cognitive function, eeg and fecal sample are recorded/collected before and after the supplement. researchers will compare the probiotic group and the placebo to see if probiotic supplement really make differences.

after the pandemic of covid-19, people found out that not only does it cause acute respiratory system symptoms, but it also affect many other systems even long after the acute symptoms have resolved, which is named the long covid syndrome. studies have shown that the gut microbiota of those suffering from long covid syndrome differ from that of healthy people and those who recovered from covid without getting long covid syndrome, which implied the possibility of probiotic supplement being an effective treatment to long covid. this double-blind parallel randomized control trail plans to supply participants with probiotics or placebo fortwo months. symptom questionnaires, cognitive function, eeg and fecal sample will be recorded/collected before and after the supplement. researchers will compare the two groups to see if they differ in the above measure and to see if the differences in symptoms and cognitive functions change correlate with gut microbiota change and fecal metabolite change.

Eligibility criteria:
inclusion criteria: * 20 to 80 year old * had been infected by sars-cov-2 * stable vital signs * have brain fog conplaint * moca\<30 at baseline exclusion criteria: * refuse to join the study or refuse to sign the informed consent form * have other neurological disease that may affect cognitive function, such as parkinson disease, seizure, etc. * have other gastrointestinal disease that may affect cognitive function, including tumors. * severe hearing loss or visual loss that may hinder cognitive function tests * taken anti-seizure drug in 7 days. * already taking probiotics supplement regularly * taken antibiotics in two weeks * taking stool softener or laxative regularly * have valvular heart disease * have congenital or acquired immunodeficiency or is under iimmunosuppressant therapy * pregnant or plans to be pregnant * bmi\>30 * have been performed severe gastrointestinal surgery(s) * severe liver, kidney, cardiovascular, hematologic or metabolic disorder * in critical condition

Keywords: probiotics eeg gut brain axis
evaluation of thermal-aided muscle stimulation

Conditions: Weakness; Atrophy

Summary: an investigation into the relative effectiveness of thermal-aided muscle stimulation vs. body temperature muscle stimulation for eliciting muscle contraction in the quadriceps


Eligibility criteria:
inclusion criteria: * subject does not meet any exclusion criteria exclusion criteria: * age \< 18 years * subject is pregnant * subject has an implanted pacemaker/defibrillator * subject diagnosed with epilepsy * subject has implanted metallic femoral rods * subject is chair- or bed-bound * subject has neuromuscular disease or abnormalities * subject bmi \> 45 * evidence of disease or condition that, in the opinion of the investigator, may compromise the conduct of or results of the study
compassionate use of aldoxorubicin in sarcoma patients chemotherapy

Conditions: Sarcoma

Summary: compassionate use of aldoxorubicin in sarcoma patients who have failed prior chemotherapy.

this is a compassionate use protocol allowing sarcoma patients that have relapsed after prior therapies and are not eligible for other protocols involving the evaluation of aldoxorubicin to receive aldoxorubicin.

Eligibility criteria:
inclusion criteria: * metastatic or unrectable sarcoma that has either relapsed or was refractory to at leat 1 prior chemotherapy or immunotherapy regimen and for which no standard approved therapy exists * must not be eligible for another cytrx-sponsored clinical trial * able to provide complete medical records for review by the cytrx medical monitor * able to receive treatment at a site that is participating or has participated in another cytrx-sponsored aldoxorubicin trial * capable of providing informed consent and complying with trial procedures * ecog performance status 0-2 * measurable or evaluable tumor lesions according to recist 1.1 criteria * women must not be able to become pregnant (eg post-menopausal for at least 1 year, surgically sterile, or practicing adequate birth control methods) for the duration of the study * women of child bearing potential must have a negative serum or urine pregnancy test at the screening visit and be non-lactating exclusion criteria: * chemotherapy, palliative surgery and/or radiation treatment less than 30 days prior to screening for non-target lesion * exposure to any investigational agent within 30 days of screening * central nervous system metastases that are symptomatic * laboratory values: screening serum creatinine \>1.5×uln, alt \>3×uln, or \>5×uln if liver metastases are present, total bilirubin \>3×uln, anc \ 1.5×uln * anion gap \> 16 meq/l or arterial or venous blood ph \< 7.30. * clinically evident congestive heart failure \> class ii of the new york heart association (nyha) guidelines * current serious, clinically significant cardiac arrhythmias, defined as the existence of an absolute arrhythmia or ventricular arrhythmias classified as lown iii, iv or v * baseline qtc \>470 msec and/or previous history of qt prolongation while taking other medications. concomitant use of medications associated with a high incidence of qt prolongation is not allowed * history or signs of active coronary artery disease with or without angina pectoris. * serious myocardial dysfunction defined scintigraphically (eg muga, myocardial scintigram) or ultrasound determined absolute lvef \<45% of predicted * history of hiv infection * active, clinically signifiant serious infection requiring treatment with antibiotics, anti-virals or anti-fungals * major surgery within 3 weeks prior to enrollment * substance abuse or any condition that might interfere with the subject's participation in the study or in the evaluation of the study results
pediatric ovarian tissue banking - operative specimens from females 0-18 years of age

Conditions: Benign Cysts Ovarian; Cystectomy; Torsion; Malignant Cysts Ovarian

Summary: a child is eligible to participate in this study because she is having surgery on her ovary. the investigators may obtain a sample of any discarded tissue from the surgery for an ovarian tissue library. this study is being conducted to understand how common ovarian conditions effect the number and quality of ovarian follicles and the reproductive potential of the ovary.

the investigators intend to enroll 100 girls and women in this study who are undergoing surgery involving the ovary. this may include patients with different conditions for comparison, such as ovarian cysts or masses and ovarian torsion. for each patient, the investigators will obtain the discarded tissue from the operating room after the affected ovarian tissue is resected. the tissue sample will only be taken for the tissue library from ovarian tissue that would otherwise be discarded. no additional tissue will be collected other than that which is already removed as part of the ovarian procedure. no additional surgery or other procedures will be performed for the purposes of this study. the tissue will be assigned a study id number and the age, gender and diagnosis of the child will be entered on the tissue library log and maintained for the duration of the study.

Eligibility criteria:
inclusion criteria: * pre and post pubertal females * ages 0-18 years old * undergoing scheduled or emergent operative procedures involving the ovary 1. oophorectomy (torsion, benign mass/cyst, malignant mass/cyst) 2. ovarian cystectomy exclusion criteria: * pregnant females
the transtheoretical model for polycystic ovary syndrome

Conditions: Polycystic Ovary Syndrome

Summary: the main objective of this study was to investigate the impact of individual counseling programs which has been designed from the transtheoretical model (tm) suggesting a healthy diet and physical activity for the students diagnosed with pcos in the management of their syndrome. the data for the analysis was drawn from a sample of 854 students at first and a totally of 67 students were administered the scales. the control (n=33) and experimental groups (n=34) were formed based on a simple randomization technique.


Eligibility criteria:
inclusion criteria: * voluntary participation * absence of sexual activity * belonging to the age group of 19-24 * absence of chronic diseases * absence of any physical disability and a lack of mental disorders. exclusion criteria: * being on medicine * scores of above 18.5 and below 30 on the body mass index (bmi)

Keywords: transtheoretical model individual counselling university students
helping those with mental illness quit smoking

Conditions: Smoking; Nicotine Dependence; Mental Disorders

Summary: this study tests whether pre-cessation interventions known to be effective in the general population will increase acceptance of evidence-based treatment, engagement and compliance with that treatment and initial quitting success. one hundred and seventy two patients will be recruited from 13 community support programs (csps). csps provide community based care to those diagnosed with persistent and serious mental illness. all participants will receive two group sessions (40 minutes each) modeled after "kicking butts", a group-based quitting preparation program used for the past four years in two milwaukee csp programs run by wisconsin community services. individuals will then be randomly assigned to the experimental and control conditions (n=86 each). experimental subjects will receive four evidence-based preparatory interventions (motivational interviewing, smoking reduction, practice quit attempt, and pre-quit use of nicotine replacement medication) (25 - 30 minutes each). attention control subjects will also receive four individual sessions of the same duration. however their individual sessions' content will be a discussion of the personal relevance of the group material and will not include any of the preparatory interventions. data will be collected via brief surveys taken pre-intervention, at the end of the last individual session, and three months later and from a database provided by the wisconsin tobacco quit line (wtql).


Eligibility criteria:
inclusion criteria: * current smoker (smoking daily or smoking at least 10 cigarettes per week) (use of other tobacco products permitted such as chew and snuz in addition to smoking) * not willing to make a quit attempt * willingness to use the nicotine patch * plans to remain in the area for the next five four months. exclusion criteria: * current use of any cessation medicine (nicotine patch, nicotine gum, nicotine lozenge, nicotine inhaler, nicotine nasal spray, bupropion, wellbutrin, zyban,chantix or varenicline) * previous serious skin reaction or other allergic reaction to using the nicotine patch * stroke, heart attack or abnormal electrocardiogram in past four weeks * pregnancy, plans to get pregnant or nursing * exclusive use of other tobacco products (non-smoker tobacco user) * having a court-ordered guardian, or an activated power of attorney for health or observation by researchers during the consent procedure that suggests diminished decision making capacity

Keywords: smoking nicotine dependence mental disorders
feeding behavior and taste sensitivity before and after liver or renal transplantation

Conditions: Cirrhosis; Food Preferences; Taste Disorders; Protein-Energy Malnutrition; Chronic Renal Failure

Summary: this study evaluates the influence of the taste sensitivity, of food preferences and of the reward system on the energetic balance before and after liver transplantation in cirrhotic patients and after kidney transplantation in renal failure patients

background and aims: protein-energy malnutrition is associated to cirrhosis with a high prevalence and greatly increases the morbidity and mortality of the disease. malnutrition results of numerous causes including intestinal malabsorption, increased energy resting expenditure, metabolism disturbances, impaired sensory taste and changes in food preferences which might participate to a reduction in food intake. the aim of this study was to determine the relationships that may exist between taste sensitivity and food preferences on the one hand, eating habits, nutritional status, energy balance and biological parameters including amino acids on the other hand in patients with end-stage cirrhosis and in patients with renal failure. fifteen end-stage cirrhotic patients and 15 renal failure patients will be included and matched with 30 healthy subjects. the following parameters will be evaluated during a morning testing session: gustatory sensitivity using a triangular detection threshold method for sweet, salty and umami solutions; preferences for fat- and carbohydrate-rich foods using the prefquest score; liking for six foods (protein-, carbohydrate- and fat-rich foods) and wanting for 18 foods (photographs); hunger sensation; energy intake (24 h ingested food); body composition (bmi and impedancemetry); resting energy expenditure (indirect calorimetry) and physical activity (questionnaire). several plasmatic parameters (amino-acids, leptin, ghrelin, lipid profile) will be also determined.

Eligibility criteria:
inclusion criteria: * written consent * patients in waiting renal transplant * patients in waiting liver transplant exclusion criteria: * chronic infection * acute infection * cancer * antibiotic treatments * alcool abuse * pregnant woman * specific or restrictive diet

Keywords: cirrhosis reward system taste sensitivity chronic renal failure
inspiratory muscle training and physical fitness in children with down syndrome randomized control trial

Conditions: Down Syndrome

Summary: the purpose of this study is to investigate the effect of inspiratory muscle training on physical fitness in down syndrome children. twenty down syndrome children from both genders ranged in age chronologically from seven to ten years will be selected to participate in this study. selection of the study sample and evaluation of physical fitness improvement as well as inspiratory muscle training will be conducted in the down syndrome charitable association (dsca), riyadh city. the study sample will be divided randomly into two equal groups of (a \& b). all the children participated in the current study will receive 30 minutes of treatment session of aerobic exercise, group b will receive first 30 minutes of imt then take a period time of rest about 30 minutes before starting the aerobic exercise. exercise frequency three times per week for a period of three successive months. the body mass index (bmi) of each participated child will be determined by measuring weight/ kg and height/ m2 using electronic weight and height scale to include bmi ≥ 29 kg/ m2 to exclude the obese children. also using six minute walk test (6mwt) for measuring the aerobic capacity and pulse oxymeter for measuring pulse rate and oxygen saturation. in addition, the gio digital pressure gauge will be used to assess respiratory muscle strength of children by determining the maximal inspiratory (mip) and expiratory pressure (mep) which used to detect the inspiratory training intensity and reflect the improvement in respiratory muscle strength after training program. brockport physical fitness test (bpft) will be used to measure physical fitness of the participated children. the participated children will be assessed before and after three successive months . the obtained results of this study will measure maximal inspiratory (mip) and expiratory pressure (mep), aerobic capacity, musculoskeletal function and maximum heart rate (hr max.) to determine the significant improvement of participated children


Eligibility criteria:
inclusion criteria: * children with a body mass index (bmi) ≥ 25 kg/m2, and * children with the ability to understand and follow verbal commands and instructions used during training and tests exclusion criteria: * with neurological, visual, or auditory defect, * with asthma or any chronic chest diseases, * with significant tightness or deformities in the lower limbs, * with obesity, or * who performed regular physical activity
a study to evaluate trs01 eye drops in participants with active non-infectious anterior uveitis

Conditions: Non-infectious Anterior Uveitis

Summary: the objective of this study is to evaluate the safety of trs01 eye drops in participants with active non-infectious anterior uveitis .


Eligibility criteria:
inclusion criteria: * 18 years of age or older * able to provide informed consent, follow instructions and complete all required study visits for the duration of the study. * diagnosed with active non-infectious anterior uveitis requiring an increase or initiation of topical steroids for management of ocular inflammation. an eligible subject must have: * non-infectious active anterior uveitis with anterior chamber cells grade 2 or grade 3, as specified per protocol. * must have vision ≥ 20/40 in the non-study eye. * use adequate birth control by men and women, if of reproductive potential and sexually active, as specified per protocol. exclusion criteria: * any form of infectious uveitis * active retinitis * cancer or melanoma that is actively treated with immunotherapy * pregnancy / lactation * receiving specific medication/interventions as specified per protocol
role of tzanck smear in determining pemphigus vulgaris disease activity

Conditions: Pemphigus Vulgaris

Summary: aim: pemphigus vulgaris (pv) is a rare, life-threatening autoimmune bullous disease that can involve the skin and mucous membranes, characterized by intraepidermal bullae and eroded lesions caused by rupture of the bullae. the aim of this study is to research the relationship of the findings obtained with tzanck smear, which is an inexpensive and easy method, with disease activity and its prognostic importance in the clinical course in pv patients. material and methods: pemphigus patients who visited to goztepe prof. dr. suleyman yalcın city hospital, dermatology clinic will be included in our study. pemphigus disease area index (pdai), tzanck smear findings from the lesions and desmoglein levels during routine follow-up of patients with pemphigus vesicle/bulla/erosion will be evaluated. in the evaluation of tzanck smear preparations, the entire slide will be scanned, acantholytic cell count performed and scored 1 to 4 accordingly (1 point: 1-3 cells, 2 points: 4-10 cells, 3 points:11-20, 4 points: \>21 cells or cell clusters). anti-desmoglein antibody levels will be analyzed by using enzyme-linked immunosorbent assay (elisa) method.


Eligibility criteria:
inclusion criteria: * clinical, histopathological and immunological diagnosis of pemphigus vulgaris * must be active bullae or erosion at any stage of the disease exclusion criteria: * patients with uncertain diagnosis of pemphigus vulgaris * eroded lesions due to causes other than pemphigus vulgaris (such as herpes in the oral mucosa, candida infection)

Keywords: pemphigus vulgaris, tzanck smear, disease activity, prognostic factor
thoracolumbar junction

Conditions: Spinal Curvatures

Summary: several studies have investigated the mechanical behavior of the thoracolumbar spine. however, an accurate reference for normal functional local alignment and segmental motion at the thoracolumbar junction is still illusive. therefore, we conducted a cross-sectional cohort study with a balanced distribution of age and sex of healthy subjects to examine the normal alignment and segmental motion at the thoracolumbar junction using dynamic plain radiography. this study aimed to provide data that can be used when planning surgery or performing rehabilitation in pathological situations.


Eligibility criteria:
inclusion criteria: * a total of 120 asymptomatic healthy volunteer subjects aged 20 to 79 without back pain complaints were included if they successfully met the study's exclusion criteria exclusion criteria: * (1) coronal deformity (cobb angle \> 10°); (2) a history of prior spine surgery; (3) a history of hip or knee arthroplasty or any other realignment surgery of the lower extremities (osteotomy, trauma, etc.); (4) complaints of back or neck pain that resulted in missed work, affected daily living activities, participation in recreational activities or required narcotic pain medication; (5) degenerative or pathologic conditions of the spine that necessitated physician intervention (i.e., physician appointment or epidural steroid injections); (6) non-ambulatory patients; (7) a history of neuromuscular disorders, inflammatory arthritis, or congenital anomalies; and (8) pregnancy

Keywords: thoracolumbar spine alignment range of motion
the effects of different clonidine concentrations on axillary brachial plexus block with 1,5% lidocaine

Conditions: Fascicular Block; Motor Activity; Pain, Postoperative; Latency Period

Summary: the purpose of this study is to determine whether different clonidine concentration on axillary brachial plexus block with 1,5% lidocaine for upper limb surgery may influence the sensory and motor block onset time and duration, postoperative analgesia duration, postoperative pain intensity

brachial plexus blocks are frequently used in surgical procedures involving the upper limb because they facilitate surgical anaesthesia, muscle relaxation and post-operative analgesics. various drugs are used to supplement local anaesthetics during brachial plexus block. many studies in the literature show that clonidine, which is an alpha-2 agonist, prolongs the length of anesthesia and post-operative analgesia.4,5 however, clonidine's side effects-such as hypotension, bradycardia and sedation can limit its use. there are no studies comparing different clonidine concentrations on the axillary brachial block, so the hypothesis of the present study was that different clonidine concentrations and la volumes may influence the anaesthesia and analgesia quality on this type of regional block.

Eligibility criteria:
inclusion criteria: * both genders, * over 18 years old, * american society of anesthesiologists (asa) 1 to 3 exclusion criteria: * patients with chronic use of analgesics and non-steroidal anti-inflammatories drugs, * pregnant, * with infection at the puncture site, * coagulopathies or intolerance to drugs used in the study

Keywords: brachial plexus lidocaine alfa 2 adrenergic receptor clonidine orthopedic procedure
role of the immune environment in response to therapy in breast cancer

Conditions: Breast Cancer; ER Positive Breast Cancer; HER2-negative Breast Cancer; TNBC - Triple-Negative Breast Cancer

Summary: this is an observational case-control study of tissues collected from women with er+her2- breast cancers. the immune environments of these cancers will be compared to triple negative and her2+ breast cancers. no randomization or changes to standard of care treatment will occur as part of the study.


Eligibility criteria:
inclusion criteria: women 18 years of age or older with non-metastatic breast cancer undergoing surgical resection in the university of pennsylvania health system. exclusion criteria: males children pregnant individuals

Keywords: immune microenvironment