Kornimate/medical-research-clean huggingface dataset:
evaluation of the association of polymorphisms in the innate immune system with the risk for cryptococcus neoformans infection in patients not infected with hiv and complications associated with cryptococcus neoformans infection

Conditions: Cryptococcosis

Summary: innate immunity plays an important role for fungal recognition and initiation of fungicidal activity. we hypothesize that subtle differences in different molecules of innate immunity may contribute to either the predisposition or clinical course of infection with cryptococcus neoformans. to test this hypothesis, we propose to analyze the allelic frequencies of 15 different genes (mannose binding lectin, fc-gamma receptor iia and iib, fc-gamma receptors iiia and iiib, myeloperoxidase, tumor necrosis factor-alpha and -beta, interleukin 1a and 1b, interleukin-1 receptor antagonist, interleukin-10, nramp-1, chitotriosidase, and chemokine receptor 5) and their intragenic polymorphic forms and to compare this data to the incidence and severity of c neoformans infection. with this study we hope to identify a group of molecules of innate immunity which influence the risk and severity of invasive c neoformans infection.

innate immunity plays an important role for fungal recognition and initiation of fungicidal activity. we hypothesize that subtle differences in different molecules of innate immunity may contribute to either the predisposition or clinical course of infection with cryptococcus neoformans. to test this hypothesis, we propose to analyze the allelic frequencies of 15 different genes (mannose binding lectin, fc-gamma receptor iia and iib, fc-gamma receptors iiia and iiib, myeloperoxidase, tumor necrosis factor-alpha and -beta, interleukin 1a and 1b, interleukin-1 receptor antagonist, interleukin-10, nramp-1, chitotriosidase, and chemokine receptor 5) and their intragenic polymorphic forms and to compare this data to the incidence and severity of c neoformans infection. with this study we hope to identify a group of molecules of innate immunity which influence the risk and severity of invasive c neoformans infection.

Eligibility criteria:
* inclusion criteria: patients diagnosed with cryptococcus neoformans infection will be identified from a data base overseen by dr. peter pappas. only patients diagnosed and treated in the united states and canada will be included in this analysis. only patients who are not coinfected with hiv will be included in the study. patient samples will be collected and clinical data will be evaluated only after signed informed consent has been obtained.

Keywords: risk factor genetic variant alleles cancer transplantation
a combinatorial biomarker for infection diagnosis in children

Conditions: Respiratory Tract Infections; Fever

Summary: to describe the epidemiology, clinical presentation, diagnosis, therapy, and treatment outcomes of patients in whom the combination biomarker bv (combination of trail, ip-10, and crp) is used, and to compare them with control patients without bv measurement. secondary objectives: * qualitative evaluation of indication as well as adherence to the test result. * comparison of antimicrobial therapy, performed diagnostics, hospitalization, and outcomes between patients with high bv score (bacterial) and patients with low bv score (viral).


Eligibility criteria:
inclusion criteria: * suspicion of acute bacterial or viral infection * requirement of at least one bv test during medical presentation exclusion criteria: * lack of informed consent
prediction of pacu delirium using eeg - german validation study

Conditions: Delirium

Summary: aim of this observational study is to investigate whether frontal electroencephalogram analysis is able to predict increased risk for pacu delirium.

delirium in the postoperative anaesthesia care unit (pacu), a special of form of postoperative delirium, is associated with increased hospital stay and an elevated hospital re-admission rate. first studies investigating the patients' electroencephalogram (eeg) on emergence from anaesthesia were able to show that an abrupt change of predominant eeg-rhythm is associated with an increased rate of pacu delirium. therefore, it seems possible to use frontal eeg in order to identify patients being at elevated risk for pacu delirium. aim of this observational study is to validate the results of an international collaboration in a german population of patients undergoing general anaesthesia. eeg in these patients is recorded from start of anaesthesia until emergence. rate of pacu delirium is assessed using the cam-icu score 15 and 60 minutes after emergence in the recovery room. in a pilot study in 626 patients from 2013 to 2015 in 5 international study centres the rate of pacu delirium was 20%. as it is planned to investigate 5 co-factors using regression analysis 50 cases of delirium will be necessary for a sufficient analysis. therefore, in total 250 patients will be included. due to an additional study centre that included 50 patients enrolment of the german validation group was completed after 200 patients.

Eligibility criteria:
inclusion criteria: * age: 18 years or older * surgery in general anaesthesia exclusion criteria: * emergency surgery * general anaesthesia within 30 days before

Keywords: eeg pacu delirium
topical umbilical cord care for the prevention of colonization and invasive infections

Conditions: Colonization

Summary: umbilical catheters are necessary for many infants admitted to the newborn intensive care unit (nicu)and utilized when indicated for up to 7 to 14 days. bacterial colonization can occur at the umbilical stump and potentially lead to serious bloodstream infections (bsis). this study is a prospective, randomized controlled feasibility trial to evaluate three types of hygiene products on umbilical line stumps, on the effect of line colonization and subsequent infections. infants admitted to the nicu with an umbilical line(s) will be randomized into one of four study groups, three products against standard of care (no product). the three products that will be evaluated are currently being used in different capacities for skin care in the uva nicu. the study hypothesizes that daily topical application of 1 or more antiseptic to the top of the umbilical stump will decrease colonization of the umbilical stump while umbilical lines are in place.

umbilical catheter associated infections are higher (4.4 vs. 3.4 clabsis per 1000 line days) than other central lines such as piccs and surgically placed cvlin the nicu. (www.cdc.gov - nshn 2010 report). routine care of the skin entry site (e.g. central line dressing care) is standard for other central lines, but there is no standard for care of the umbilical stump while umbilical lines are in place. in a pilot study to evaluate the relationship of umbilical stump colonization with gestational age, the number of days the catheter was in place, and the type of organisms, colonization was detected in 78% of patients. there was a direct correlation with colonization and line days as well as an inverse relationship with lower gestational age. this pilot data supported the need for the study of interventions to reduce umbilical stump colonization, which may help decrease blood stream infections (bsis) associated with umbilical lines in the nicu. the proposed study will evaluate feasibility of once daily product application.

Eligibility criteria:
inclusion criteria: \*≤7 days of life \*umbilical line(s) in place (uac and/or uvc) exclusion criteria: \*not meeting inclusion criteria

Keywords: newborn intensive care unit neonatal intensive care unit colonization line colonization umbilical line umbilical cord care
effect of vascular inflow occlusion in open liver resection for hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma

Summary: bleeding is a major problem during liver resection. vascular inflow occlusion, also known as pringle maneuver, has been commonly employed to reduce blood loss during liver surgery. however, pringle maneuver might cause ischaemic insult to the remnant liver and lead to post-operative liver dysfunction. the investigators hypothesize that liver resection without the use of vascular inflow occlusion (pringle maneuver) is associated with lower postoperative complications rate. the aim of this study is to evaluate whether elective open liver resection without vascular inflow occlusion (pringle maneuvre) would lead to a reduction of post-operative surgical complications in patient with hepatocellular carcinoma. eligible patients undergoing liver resection in the prince of wales hospital will be recruited and randomized into 2 study arms comparing the effect of pringle maneuver.


Eligibility criteria:
inclusion criteria: * age \>18 * child's a or b cirrhosis exclusion criteria: * informed consent not available * presence of portal vein thrombosis, portal vein tumor thrombus, or previous portal vein embolisation * presence of hepatic artery thrombosis, previous transarterial therapy like tace, lipiodol-ethanol mixture injection or transarterial internal radiation * anticipation of portal vein resection * emergency hepatectomy * ruptured hcc * adhesion or anatomical variation that preclude safe and successful application of pringle maneuver * anticipation of concomitant bowel or bile duct resection

Keywords: hepatectomy vascular inflow occlusion
effect of cold air cooling on the incidence of post inflammatory hyperpigmentation following laser treatment

Conditions: Nevus; Hyperpigmentation

Summary: - to investigate the benefit of epidermal cooling on the incidence of post inflammatory hyperpigmentation after laser irradiation

* 70% incidence of post inflammatory hyperpigmentation has been reported following a q-switched nd:yag laser treatment of acquired bilateral nevus of ota-like macules. * we assumed that epidermal cooling may minimize the non-specific injury to the epidermis caused during laser irradiation, leading to the decreased incidence of post inflammatory hyperpigmentation.

Eligibility criteria:
inclusion criteria: * subjects with acquired bilateral nevus of ota-like macules. * at least 18 years old * no previous treatment on the condition for a minimum period of 1 month. exclusion criteria: * subjects diagnosed of scleroderma, connective tissue disorders, hematologic disorders, hepatitis, infection, or uncontrolled dm * history of keloid and/or hypertrophic scar. * currently on anti-coagulant

Keywords: acquired bilateral nevus of ota-like macules postinflammatory hyperpigmentation cold air cooling
asan medical center ccta registry

Conditions: Coronary Artery Disease; Risk Factor; Computed Tomography

Summary: a total of 9269 adults who received ccta scans for coronary disease evaluation during a general medical checkup at the health screening and promotion center in asan medical center, seoul, korea between january 2007 and december 2011 were initially selected. all participants were provided with information about the potential benefits and risks of ccta and made the decision to undergo the procedure at their own expense. they were also informed that their clinical and radiological data would be used for this study and gave their consent. of these individuals, 7129 agreed to participate, and 6343 were enrolled in this ccta registry.


Eligibility criteria:
exclusion criteria: 1. a previous history of angina or myocardial infarction; 2. abnormal rest electrocardiographic results, i.e., pathological qwaves, ischemic st segments or t wave changes, or left bundle-branch blocks; 3. insufficient medical records; 4. structural heart diseases; 5. a prior history of open heart surgery or percutaneous coronary intervention; 6. a previous cardiac procedure; or 7. renal insufficiency (creatinine n1.5 mg/dl)
equivalence of new breath analyzercompared to currently breathid system in assessment of liver function

Conditions: Chronic Liver Disease (CLD); Healthy Volunteers

Summary: the aim of the study is to confirm that the new generation state of the art breath analyzer gives equivalent results to the previous model of the exalenz breath analyzer.

healthy and chronic liver disease subjects of all grades will be tested to see that the two devices give equivalent results in both devices. subjects will be connected to both devices at the same time and will be tested for one hour. the breath test includes automatic baseline breath collection, 13c-methacetin ingestion in solution and breath collection post ingestion.

Eligibility criteria:
inclusion criteria: 1. over 18 years of age 2. ability and willingness to sign the informed consent form for patient group: 3. a. known chronic liver disease (based on medical history) for healthy volunteers: 3.b. no known liver disease (based on medical history) exclusion criteria: 1. gastric bypass surgery or extensive small bowel resection 2. total parenteral nutrition 3. pregnant or breast feeding 4. allergy to acetaminophen and/or other related medications. 5. documented drug-related concurrent hepatotoxicity or drug-related silent steatosis or drug-related fibrosis (e.g. amiodarone, methotrexate and tamoxifen). 6. uncontrolled malabsorption or diarrhea 7. placement of a transjugular intrahepatic portosystemic shunt (tips) 8. subject should not have taken any of the following for at least 48 hours prior to the breath test: acyclovir, allopurinol, carbamazepine, cimetidine, ciprofloxacin, daidzein, (herbal) disulfiram, echinacea, enoxacin, famotidine, fluvoxamine, methoxsalen, mexiletine, montelukast, norfloxacin, phenylpropanolamine, phenytoin, propafenone, rifampin, terbinafine, ticlopidine, thiabendazole, verapamil, zileuton or oral contraceptives or any medication that might interfere with methacetin metabolism or might affect cyp 1a2 9. subject should not have taken amiodarone within the last 30 days prior to the breath test

Keywords: cld
transcorneal electrostimulation for therapy of retinitis pigmentosa

Conditions: Retinitis Pigmentosa

Summary: the purpose of this study is to determine the long-term effects of transcorneal electrostimulation (tces) in patients with retinitis pigmentosa (rp). in a prior study (nct00804102) the results of short-term stimulation showed a positive effect on the visual field and other parameters. in this study, the patients will be stimulated with either 0%, 150% or 200% of the individually determined phosphene threshold.

the study was performed at the centre for ophthalmology, university of tübingen, germany. the protocol was approved by the local ethics committee. all procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the helsinki declaration of 1975, as revised in 2008. informed consent was obtained from all patients for being included in the study. the study was conducted according to the standards of gcp, the european union directive for medical devices, and the german medical product law. patients were seen at 14 visits over a period of 78 weeks: one baseline visit (screening), followed by 12 visits (in week 1-4 weekly, then in weeks 10, 16, 22, 28, 34, 40, 46 and 52; dates varied a maximum of ± 1 week) including application of tces for 52 weeks and one follow-up visit (in week 78, dates varied a maximum of ± 1 week). after inclusion patients were randomly assigned to tces with 0 ma (sham), 150% or 200% of their individual electrical phosphene threshold (ept) current at 20 hz. patients and technicians who performed kinetic perimetry, as well as full-field electrophysiology (erg), multifocal erg (mferg) and dark adaptation, were blinded to the treatment group for the entire study period. the physicians who performed all other examinations and tces were not blinded to study treatment because they were responsible for setting the stimulation parameters.

Eligibility criteria:
inclusion criteria: * adult subject with rp (rod-cone dystrophy) * bcva 0.02 to 0.9 * reliable visual field measurements * reliable erg measurements * skillful enough to use the device at home * able to give consent and take part during the whole study exclusion criteria: * diabetic retinopathy * neovascularisation of any origin * after arterial or venous occlusion * after retinal detachment * silicone oil tamponade * dry or exudative age-related macular degeneration * macular edema * all forms of glaucoma * any form of corneal degeneration that reduces visual acuity * systemic diseases that are difficult to control or manage, that could endanger the normal study schedule * patients in a permanently poor general condition, which could hinder the regular attendance at control examinations in the clinic * forms of mental illness related to the bipolar affective and schizoid-affective disorders, and all forms of dementia * simultaneous participation in another interventional study or history of interventions whose effect may still persist

Keywords: transcorneal electrostimulation tces tes
a first in human study for the versa device for tricuspid regurgitation

Conditions: Tricuspid Regurgitation

Summary: this study is prospective, non-randomized, single-arm,first in human study to evaluate the safety and feasibility of the versa vascular system for intervention in adults with severe tricuspid regurgitation who are not surgical candidates.


Eligibility criteria:
inclusion criteria: * tricuspid regurgitation (tr) associated symptoms despite optimal medical treatment. * tr ≥ 3 as determined by the assessment of a transthoracic echocardiogram or transesophageal echocardiogram. * the local multi-disciplinary heart team agrees that the participant is a poor candidate for surgery. * age ≥ 18 years at the time of consent. * ability and willingness to provide written informed consent prior to any study related procedure(s). exclusion criteria: * severe pulmonary hypertension. * severe uncontrolled hypertension systolic blood pressure (sbp) ≥ 180 mmhg and/or diastolic blood pressure (dbp) ≥ 110 mmhg. * any condition that would interfere with the versa procedure, such as prior tricuspid valve repair or tricuspid valve leaflet anatomy which may preclude successful device implantation, pacemaker or implantable cardioverter defibrillator (icd) leads that would prevent appropriate placement or visualization of versa implant, ebstein anomaly (normal annulus position, but valve leaflets attached to walls and septum of the right ventricle), tricuspid valve anatomy non-evaluable by echocardiography. * known allergy to antiplatelet therapy, heparin, or to device materials. * femoral venous mass or thrombus or vegetation. * tricuspid valve anatomy not compatible with the versa implant * undergone any heart valve surgery within prior 60 days. * tricuspid valve stenosis - defined as a tricuspid valve orifice of ≤ 4.0 cm2. * severe mitral regurgitation. * left ventricular ejection fraction (lvef) ≤ 20% * active endocarditis, other ongoing infection requiring antibiotic therapy. * myocardial infarction or percutaneous coronary intervention within prior 30 days. * cardiogenic shock or the need for inotropic support or hemodynamic support device (e.g., intra-aortic balloon pump). * cerebrovascular accident (cva) within prior 30 days * active gastrointestinal (gi) bleeding * life expectancy of less than 12 months independent of tricuspid valvular disease. * subject currently participating in another clinical study (not yet completed primary endpoint). * pregnant or nursing subjects or those who plan pregnancy during the study. * the presence of anatomic or comorbid conditions, or other medical, social, or psychological conditions that, in the eye of the investigator, limits the subject's ability to participate in the clinical investigation or comply with follow-up requirements. * absence of appropriate venous access. * unwillingness to complete the required follow-up visits.
analgesic effect of pregabalin in patients undergoing total abdominal hysterectomy

Conditions: Pain

Summary: pregabalin will decrease the total amount of opioid required in patients undergoing total abdominal hysterectomy. in addition, pregabalin will decrease the incidence of opioid-related side effects in patients undergoing total abdominal hysterectomy.


Eligibility criteria:
inclusion criteria: * asa physical status 1-2 * age 18-64 * bmi 18-35 * scheduled for elective total abdominal hysterectomy (with or without bilateral salpingo-oophorectomy) * gender: female * consent: obtained exclusion criteria: * patient refusal * allergy to study medication(s) * preoperative use of gabapentinoids * preoperative use of anticonvulsants * daily use of analgesics * hepatic disease * renal insufficiency (cr \>2.0) * alcohol or drug abuse * pregnancy * language: non-english speaking * patient expected to remain intubated after procedure dropout: * patient request * surgeon request * allergic reaction to pregabalin * surgical procedure significantly altered from scheduled procedure

Keywords: hysterectomy pain pregabalin
pain pressure threshold algometry in lateral epicondylitis: intra- and inter-rater reliability

Conditions: Lateral Epicondylitis; Lateral Epicondylitis, Unspecified Elbow

Summary: this clinical trial aims to investigate the intra- and inter-rater reliability of pain pressure threshold algometry in lateral epicondylitis patients.

tennis elbow, also known as lateral epicondylitis (or epicondylosis) of the elbow, was first described at the end of the 19th century. the community prevalence is 1% to 3%,38 with an even sex distribution and a peak incidence between 35 and 55 years of age.16 there is consensus that the mechanism of injury involves repetitive loads at the wrist and elbow, including supination and extension of the wrist.15 people affected by tennis elbow commonly have pain over the lateral humeral epicondyle, with flexion at the elbow also usually limited by pain, especially if the wrist is pronated and extended against resistance. assessment of reliability is a necessary first step in the validation procedures of clinical tests. the reliability of the ppt measurement is susceptible to the influence of rater behavior and judgment, such as the instructions to the participant, rate of force application, and reaction time of the rater. we opted to investigate the intra- and inter-rater reliability of ppt in persons with lateral epicondylitis with three raters, rater blinding, and a pause of ≥20 seconds between each measurement. we hypothesized that clinicians with no former experience with the procedure can master it with good reliability after a single 30-min training session.

Eligibility criteria:
inclusion criteria: * must be between 18 and 90 years of age * clinical diagnosis of lateral epicondylitis (point tenderness over the lateral epicondyle and exacerbation of pain with chair pick-up test and maximal hand grip) exclusion criteria: * history of steroid injection for the treatment of lateral epicondylitis within six months * history of oral steroid use for the treatment of lateral epicondylitis within six months * history of elbow surgery * history of elbow fracture * history of elbow dislocation * cancer * rheumatoid arthritis * severe cognitive deficit * neurological deficits in the upper limb * inability to speak and understand english/turkish.