Kornimate/medical-research-clean huggingface dataset:
cerebrovascular autoregulation in sepsis, influence of renal replacement therapy

Conditions: Severe Sepsis; Septic Shock

Summary: the cerebrovascular autoregulation is impaired in patients with severe sepsis and septic shock. a continuous veno-venous hemodialysis may improve impaired cerebrovascular autoregulation. hypothesis: continuous hemodialysis recovers impaired cerebrovascular autoregulation in patients with acute severe sepsis and septic shock.


Eligibility criteria:
inclusion criteria: * severe sepsis or septic shock * adult patients * possibility of transcranial doppler ultrasound exclusion criteria: * traumatic brain injury * known cerebrovascular diseases * infection of the brain * chronic renal failure * pregnancy

Keywords: sepsis cerebrovascular autoregulation delirium
systemic prevention and management for perioperative hypothermia and its effect on patients outcome

Conditions: Hypothermia; Anesthesia

Summary: this is a randomized, single-blinded, multi-center study clinical trial to determine both clinical and health outcomes of stratified warm strategy to prevent intraoperative hypothermia. participants enrolled into this trial will be from elective major surgery population in pumc hospital, beijing hospital and xuanwu hospital. investigators plan to enroll approximately 800 participants. hypothermia risk will be evaluated through predictor model in all participants. according to hypothermia risk level, these participants will be stratefied into high, moderate and low risk group. participants in each group will be randomly categorize into warm group and control group. active warm and fluid warm strategy, prewarm and fluid warm strategy and only prewarm strategy are used for high risk, moderate risk and low risk patients seperately. for controll group traditional passive warm was used.


Eligibility criteria:
inclusion criteria: age≥18 core temperature preoperation ≥36.0 ℃ and ≤37.5℃ asa i-iii informed consent exclusion criteria: * emergency operation * uncontrolled diebete mellitus with insulin treatment （preoperative blood glucose\>250mg/dl） * hyperthyroidism and hypothyroidism * raynaud's disease * patients with hematopathy and immune disease * anticoagulant and non-steroid anti-inflammatory drug intake with 14 days before operation * infectious fever within 4 weeks before operation * laboratory abnomality as follow * hemoglobin≤10.0g/l * platelet≤100,000/ml * white blood cell\ 14,000/dl * fibrinogen\<200mg/dl * thrombin time\>40 second * international normalized ratio\<70%

Keywords: hypothermia
chlorhexidine vaginal cleansing versus iodine prior to c-section and the rate of postoperative infection

Conditions: Vaginal Scrubbing

Summary: background: women undergoing cesarean delivery have 5 to 20 fold greater risk for infection and infectious morbidity compared with those undergoing vaginal birth. endometritis, febrile morbidity, and wound infection are the most frequent complications of post cesarean infections. endometritis accounts for 6-27% followed by clinically significant fever, which was reported about 5-24%,while the incidence of wound infection is about 2-9%.previous studies evaluated whether vaginal cleansing can reduce the incidence of postoperative infectious morbidity. in most of the studies, povidone iodine was used as intervention. objectives: the aim of this study is to test the hypothesis that preoperative vaginal cleansing with chlorhexidine would be superior to iodine for the prevention of maternal infectious morbidities including endometritis, fever and wound complications. methods: this prospective randomized single blinded controlled trial will be conducted at makassed general hospital between february 2018 and january 2019. total of 300 patients, 150 in each group, will be enrolled. group 1 patients will receive chlorhexidine vaginal cleansing while group 2 patients will receive iodine prior to c-section. adverse post infectious morbidities such as endometritis, febrile illness and wound infections will be observed within 30 days of c-section.

this prospective randomized single blinded controlled trial will be conducted at makassed general hospital between february 2018 and january 2019. all pregnant women who will undergo cesarean delivery and willing to sign the informed consent will be included. total of 300 patients, 150 in each group, will be enrolled. group 1 patients will receive chlorhexidine vaginal cleansing while group 2 patients will receive iodine prior to c-section. adverse post infectious morbidities such as endometritis, febrile illness and wound infections will be observed d within 30 days of c-section. vaginal cleansing will be performed in conjunction with the abdominal preparation with foam sponge that contains either chlorhexidine or iodine, sponge will be inserted into the vagina and rotated 360 degrees in the vaginal cavity for about 30 sec. all participants will receive a single body mass index (bmi) based antibiotic dose of cefazolin within 30 minutes prior to the incision.

Eligibility criteria:
inclusion criteria: * all pregnant women who will undergo cesarean delivery * and willing to sign the informed consent. exclusion criteria: * known allergy to the antiseptics used * infection diagnosis on admission * age ≤ 17 years
attentional bias modification in patients with posttraumatic stress disorder

Conditions: Posttraumatic Stress Disorder

Summary: randomized, placebo-controlled trial of 9 sessions of computerized attentional bias training on attentional bias and on symptoms of posttraumatic stress disorder.


Eligibility criteria:
inclusion criteria: * diagnosis of posttraumatic stress disorder exclusion criteria: * diagnosis of psychosis, drug- or alcohol dependency/abuse; * unable to fill in questionnaires in dutch; * color blindness (stroop test).
diaphragmatic function as a biomarker

Conditions: Dyspnea; Asthmatic; COPD; Fibrosis; Pulmonary Hypertension; Asthma; Dyspnea

Summary: dyspnea is among the most common symptoms in patients with respiratory diseases such as asthma, chronic obstructive pulmonary disease (copd), fibrosis, and pulmonary hypertension. however, the pathophysiology and underlying mechanisms of dyspnea in patients with respiratory diseases are still poorly understood. diaphragm dysfunction might be highly prevalent in patients with dyspnea and respiratory diseases. the association of diaphragm function and potential prognostic significance in patients with respiratory diseases has not yet been investigated.

the aim of the present project is to comprehensively measure respiratory muscle function and strength in patients with respiratory diseases. the investigators attempt to recruit 800 patients across four disease groups (asthma, copd, fibrosis, and pulmonary hypertension) and the investigators intend to measure diaphragm and accessory respiratory muscle function and strength, lung function, and exercise tolerance, as well as the participants' symptom burden during one day at baseline in the investigators' lab. thereafter, the investigators will follow up on patients by phone 3 months, 6 months, 12 months and 18 months after the investigators have seen them in the investigators' lab. based on these results, not only the association between dyspnea exercise tolerance and diaphragm function in patients with respiratory diseases can be assessed, but also the prognostic significance of diaphragm dysfunction in these patients can be determined. as such, hospitalization and exacerbation requiring the intake of steroids will be assessed and followed up on by phone, and therefore the prognostic significance of diaphragm dysfunction in predicting hospitalization and the intake of steroids can be determined.

Eligibility criteria:
inclusion criteria: * patient has one of the following lung diseases: copd, bronchial asthma, pulmonary fibrosis, pulmonary hypertension * is 18 years or older * is mentally and physically able to understand the study and to follow instructions * are legally competent * signed declaration of consent exclusion criteria: * bmi \> 35 * current or treatments or diseases in the past which could influence the evaluation of the study * expected lack of willingness to actively participate in study-related measures * alcohol or drug abuse * disc herniation/prolapse * epilepsy * wheelchair bound * in custody due to an official or court order * in a dependent relationship or employment relationship with investigating physician or one of their deputy * emergency inpatient hospital stay within 4 weeks before study-specific examinations

Keywords: dyspnea copd asthma fibrosis pulmonary hypertension pneumology
assisting in decisions in emergency departments: (ed-aid) study

Conditions: Suicide; Emergencies

Summary: this study will test a patient decision aid about safe firearm storage during suicidal crisis. the investigators hypothesize that participants with higher quality decisions after the decision aid will be more likely to change their firearm storage to reduce access during the time of crisis.

limiting access to a firearms during suicidal crisis can save lives. this study will test a patient decision aid about safe firearm storage during crisis. the investigators will enroll 60 adult emergency department patients being evaluated for suicidal risk and have at least one firearm at home. if available, the investigators will also enroll a family member or friend. participants will randomly receive one of two things: the decision aid or general suicide prevention information. a week later, the investigators will call participants to see how both groups choose to store their firearms. this trial tests the acceptability of the decision aid, effects on decision making, effect on home storage, effect on suicide outcomes, and feasibility of a larger trial. the investigators hypothesize that participants with higher quality decisions after the decision aid will be more likely to change their firearm storage to reduce access during the time of crisis; should the pilot demonstrate feasibility, in a subsequent larger trial this hypothesis would be tested directly.

Eligibility criteria:
inclusion criteria: * being evaluated in the emergency department for suicidal ideation/suicide attempt * deemed medically stable by ed physician * age greater than or equal to 18 years old * able and willing to have telephone follow up at 1 week * report at least one firearm in the home exclusion criteria: * unable to participate medically or cognitively (e.g. sustained altered level of consciousness, hostility, psychosis, sexual assault victim, severe vomiting or pain) * currently in legal custody * live in group home or other supervised custody * already enrolled

Keywords: firearm lethal means decision aid
safety, tolerability and pharmacokinetics of single rising inhaled doses of bi 11054 cl administered with the respimat® in healthy male volunteers

Conditions: Healthy

Summary: to investigate safety, tolerability, and pharmacokinetics of bi 11054


Eligibility criteria:
inclusion criteria: * healthy male based upon a complete medical history, including the physical examination, regarding vital signs (bp, pr), 12-lead ecg measurement, and clinical laboratory tests. there is no finding deviating from normal and of clinical relevance. there is no evidence of a clinically relevant concomitant disease. * age ≥21 and ≤50 years * body mass index (bmi) ≥18.5 and \<30 kg/m2 * signed and dated written informed consent prior to admission to the study in accordance with good clinical practice and the local legislation exclusion criteria: * any finding of the medical examination (including bp, pr, and ecg measurements) deviating from normal and of clinical relevance * evidence of a clinically relevant concomitant disease * gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders * diseases of the central nervous system (such as epilepsy) or psychiatric disorders or neurological disorders * history of relevant orthostatic hypotension, fainting spells or blackouts * chronic or relevant acute infections * history of relevant allergy/hypersensitivity (including allergy to the drug or its excipients) as judged clinically relevant by the investigator * intake of drugs with a long half-life (\>24 hours) within at least 1 month or less than 10 half-lives of the respective drug prior to randomisation * use of drugs which might reasonably influence the results of the trial based on the knowledge at the time of protocol preparation within 10 days prior to randomisation * participation in another trial with an investigational drug within 2 months prior to randomisation * smoker (\>10 cigarettes or \>3 cigars or \>3 pipes/day) * inability to refrain from smoking on trial days as judged by the investigator * alcohol abuse (more than 40 g alcohol a day) * drug abuse * blood donation (more than 100 ml blood within 4 weeks prior to randomisation or during the trial) * excessive physical activities within 1 week prior to randomisation or during the trial * any laboratory value outside the reference range that is of clinical relevance * inability to comply with dietary regimen of the study centre the following exclusion criteria are specific for this study due to the known class side effect profile of ß2-mimetics: * asthma or history of pulmonary hyperreactivity * hyperthyrosis * allergic rhinitis in need of treatment * clinically relevant cardiac arrhythmia * paroxysmal tachycardia (\>100 beats per minute)
extension to safety and efficacy of probuphine in the treatment of opioid dependence

Conditions: Opioid Dependence

Summary: buprenorphine (bpn) is an approved treatment for opioid dependence; however, in taking oral tablets, patients experience withdrawal and cravings when the variable bpn levels in the blood are low. probuphine (buprenorphine implant) is an implant placed just beneath the skin that contains bpn. it is designed to provide 6 months of stable bpn blood levels. this study will test the safety and efficacy of probuphine in the treatment of patient with opioid dependence. patients who have completed 24 weeks of treatment in the randomized, double-blind, placebo-controlled, multi-center study of probuphine in patients with opioid dependence, will be re-treated with probuphine over an additional 24 weeks.


Eligibility criteria:
inclusion criteria: * voluntarily provide written informed consent prior to conduct of any study-related procedures * completed 24 weeks of treatment in pro-805 * deemed appropriate for entry into this extension study by the investigator * females of childbearing potential and fertile males must use a reliable means of contraception exclusion criteria: * presence of aspartate aminotransferase (ast) levels ≥ 3 x upper limit of normal and/or alanine aminotransferase (alt) levels ≥ 3 x upper limit of normal and/or total bilirubin ≥ 1.5 x upper limit of normal and/or creatinine ≥ 1.5 x upper limit of normal * current diagnosis of chronic pain requiring opioids for treatment * pregnant or lactating females * current use of agents metabolized through cytochrome p450 3a4 (cyp 3a4) such as azole antifungals (e.g., ketoconazole), macrolide antibiotics (e.g., erythromycin), and protease inhibitors (e.g., ritonavir, indinavir, and saquinavir) * current anti-coagulant therapy (such as warfarin) or an inr \> 1.2 * current use of benzodiazepines other than physician prescribed use * significant medical or psychiatric symptoms, cognitive impairment, or other factors which in the opinion of the investigator, would preclude compliance with the protocol, patient safety, adequate cooperation in the study, or obtaining informed consent * concurrent medical conditions (such as severe respiratory insufficiency) that may prevent the patient from safely participating in study; and/or any pending legal action that could prohibit participation and/or compliance in study

Keywords: opioid dependence opioid addiction buprenorphine methadone heroin implant opioid withdrawal opioid pain medication suboxone
memory and scoliosis spinal exercises

Conditions: Adolescent Idiopathic Scoliosis

Summary: this is a behavioral observational study aimed at evaluating the impact that spinal exercises exert on memory of young people. it consists of a short self-administered questionnaire which will be given to adolescents with scoliosis to complete. relationships between young individuals' answers and health-related quality of life will be evaluated.

this is a behavioral observational study aimed at evaluating the impact that spinal exercises exert on memory of young people. literature found out that a memory-experience difference exists between pleasant and unpleasant situations and young people are expected to capture memories more accurately when these, as voiced for instance by outcome measures of health-related quality of life, are at their worst- rather than at their best-perceived level. in literature there are not studies which investigate the relationships between the memory of spinal exercises as for adolescents with idiopathic scoliosis and health-related quality of life. the study consists of a short self-administered questionnaire which will be given to young persons to complete. in more details, the survey is made of four questions collecting information on time to learn an exercise, time to perform an exercise, difficulty to do the exercise, commitment to perform the exercise. further, participants will have to complete a self-administered health-related quality of life questionnaire, and namely the scoliosis research society-22 patients questionnaire. descriptive statistics will be presented by taking into account the socio-demographic characteristics of the sample being investigated. statistical correlations between adolescents' answers and health-related quality of life questionnaire will be also evaluated. this study's usefulness relies on understanding which spinal exercises impact more on memory in order to increase a young persons' positive routines and improve their performance with rehabilitative programs, with the ultimate goal of growing their adherence to and satisfaction with treatment.

Eligibility criteria:
inclusion criteria: * a primary diagnosis of adolescent idiopathic scoliosis determined by expert clinicians * ability to read and understand the italian language exclusion criteria: * any diagnosable cause of scoliosis * leg-length discrepancy of \> 1 cm * lower limb deformities interfering with spinal posture, * cardiac and/or respiratory dysfunction * systemic illness * previous spinal surgery, * cognitive impairment * refusal to adhere to the study

Keywords: health-related quality of life adolescents memory scoliosis exercise
turkish validity and reliability of pain catastrophizing scale-child (pcs-c)

Conditions: Chronic Pain; Juvenile Idiopathic Arthritis

Summary: perception of chronic pain and related disability; occurs through the interaction of physiological and psychological processes. pain catastrophizing is a cognitive attribution style characterized by a negative mindset and magnification of pain. catastrophizing in children has been associated with poor functioning and higher levels of pain. catastrophizing during the transition to adulthood is defined as an important predictor of persistent pain and central sensitivity. the number of scales assessing pain and attitudes related to pain in children is quite low. in recent years, with the adaptation of the assessment scales used for adults to children or the development of new scales, the assessment of pain and pain-related attitudes in children has begun to be provided. pain catastrophizing scale (pcs), in 1995 sullivan et al. for the purpose of comprehensive assessment in adults experiencing pain-related disasters. in 2003, crombez et al. showed the validity and reliability of the scale in school-age children. for predictive validity, the scale was administered to children with chronic pain, and it was reported to predict the severity of pain and pain-related disability. pain catastrophizing scale-child (pcs-c) scale; it is a self-report measure adapted from the adult pain catastrophizing scale used to assess negative thinking associated with pain. it contains 13 items rated on a 5-point scale ranging from 0 = "not at all true" to 4 = "very true". substances; rumination (4 items, e.g. "when \[my child\] has pain, i can't get him out of my mind"), magnification (3 items, e.g. the child has pain\], thinking about other painful events"), and helplessness (6 items, e.g. "\[my child's\]\] when i have pain, i feel that i cannot continue"). items are aggregated across subscales to obtain a total score ranging from 0 to 52; higher scores are related to higher catastrophizing attitude. the pain catastrophizing scale was originally developed in german and later validity and reliability studies were conducted in different languages. the aim of this study is to question the turkish validity and reliability of the "pain catastrophizing scale-child (pcs-c)" scale.

now, the study is continuing. 50% of the participant were evaluated.

Eligibility criteria:
inclusion criteria: 1. 7-18 years old 2. agree to participate in the study 3. whose symptoms and medications are stable, 4. do not have a psychiatric disease that may affect cooperation, 5. patients with jia who do not have heart failure and lung pathology at a level that will affect their daily living activities will be included. exclusion criteria: participants who cannot understand and follow the instructions will be excluded from the study

Keywords: chronic pain juvenile idiopathic arthritis pain catastrophizing
transcutaneous posterior tibial nerve electrostimulation with low dose trospium chloride in oab in females

Conditions: Overactive Bladder

Summary: this study was done to verify whether the combination of transcutaneous posterior tibial nerve stimulation (tptns) with low dose trospium chloride in the treatment of females with overactive bladder (oab) would be more effective than tptns alone after failure of behavioral therapy.

the investigators randomized 30 women with oab, in two groups: g i (15 patients) received 30 minutes tptns, three times a week; gii (15 patients) received tptns plus low dose trospium chloride (20 mg once daily); all for 8 weeks. patients were evaluated using overactive bladder symptom score questionnaire (oabss), incontinence impact questionnaire-short form 7 (iiq-7), 3 day voiding diary and urodynamics at weeks 0 and 8.

Eligibility criteria:
inclusion criteria: * thirty adult female patients having oab symptoms (wet type) and proved to have detrusor overactivity by urodynamics exclusion criteria: 1. patients having urinary tract infection or bladder outlet obstruction. 2. patients having neurological diseases. 3. patients having gynecological problems as genital infection, pelvic organ prolapse or genital tumors. 4. patients with electronic implants such as heart pacemakers. 5. during pregnancy 6. patients subject to seizures

Keywords: ptns neuromodulation tptns trospium chloride