Kornimate/medical-research-clean huggingface dataset:
intradialytic high-intensity interval training in hemodialysis patients

Conditions: End Stage Renal Disease; Exercise, Compulsive

Summary: chronic kidney disease (ckd) is defined as a chronic, progressive degeneration state in the regulation of the fluid-electrolyte balance of the kidney and metabolic-endocrine functions as a result of the glomerular filtration rate (gfr) falling below 60 ml/min/1.73 m², regardless of the etiology of the kidney disease. end stage renal failure (esrd) is the last stage of crf and is a life-threatening condition. although the majority of esrd patients survive on dialysis, their quality of life and functional capacity decrease due to uremic cardiomyopathy, cardiovascular diseases, anemia, diabetes mellitus, bone diseases, deconditioning, fatigue, weakness, inactivity and accompanying psychological problems. rehabilitation program including exercise in ckd patients; the program, which is performed under observation on non-dialysis days, can be applied in three ways: the (intradialytic) rehabilitation program performed during hemodialysis in the dialysis unit, and the home exercise program. intradialytic exercise (ide) is defined as exercise training performed during the hemodialysis session to increase the patient's strength and endurance and thus target various physiological and psychosocial parameters. three types of exercises are generally recommended in the exercise program for dialysis patients. these are aerobic exercise, strengthening exercise, and combined aerobic and resistance exercise program. aerobic exercise (both on dialysis and on non-dialysis days) is the most common type of exercise used in hemodialysis patients. it is stated that physical exercise improves the exercise capacity, muscle strength, functional capacity and quality of life of patients receiving dialysis treatment, provides blood pressure control, reduces the risk of diabetes development and cardiovascular disease, alleviates depression and anxiety symptoms, increases survival and dialysis efficiency. when the literature is examined, no study has been found that examines how the application of high-intensity intermittent exercise training, which has very important advantages, in the intradialytic process has an effect. therefore, the aim of our study is to compare the effects of intradialytic high-intensity intermittent exercise training and moderate-intensity exercise training on dialysis effectiveness, functional capacity and quality of life in hemodialysis patients.


Eligibility criteria:
inclusion criteria: * between the ages of 20-65 * having stage 5 (esrd) crf according to gfr * literate * cooperative * dialysis treatment for at least three months exclusion criteria: * history of myocardial ischemia in the last 6 months * uncontrollable diabetes mellitus, * uncontrollable hypertension * heart failure * malignant disease * mental retardation * illiteracy * uncooperative * neurological or orthopedic disability

Keywords: intradialytic exercise high-intensity interval training chronic kidney disease dialysis adequacy functional capacity
a study to evaluate the effects of once daily doses of aqw051 on cognition, in stable schizophrenia patients

Conditions: Schizophrenia

Summary: this is a study in chronic stable schizophrenia with the purpose to answer the question of whether agonism of the nicotinic alpha7 receptor is capable of enhancing cognition in a well defined chronic stable patient population treated with antipsychotics as standard of care, and thus to support the future development of aqw051 for the treatment of cognitive impairment associated with schizophrenia (cias).


Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia * symptomatically stable and currently treated with a stable regimen for at least 3 (three) months prior to dosing with one of the following second generation of antipsychotics: risperidone, paliperidone, quetiapine, ziprasidone, aripiprazole. * specific cognitive impairment * smokers and non-smokers exclusion criteria: * current treatment with an anticholinergic or other agent known to adversely interfere with the cholinergic system, and/ or treatment with cholinesterase inhibitor within the last three (3) months prior to dosing. * current treatment with conventional antipsychotics (e.g fluphenazine, haloperidol) or clozapine. * history of neuroleptic malignant syndrome. * diagnosis of substance abuse (other than nicotine) within the last month and alcohol or substance dependence (other than nicotine) within the last 6 months. * score 4 or 5 on the suicidal ideation item or any "yes" on the suicidal behavior item of the cssr-s that is related to suicidal behavior occurring during the last 2 years other protocol-defined inclusion/exclusion criteria may apply

Keywords: schizophrenia, chronic stable schizophrenia, cognition, memory, visual learning, cogstate
prevention of lateral incisional hernia after stomal closure using p4hb retro-muscular mesh

Conditions: Incisional LLQ Hernia

Summary: the aim of the study is to determine whether the use of the p4hb retro muscular mesh can prevent the lateral incisional hernia after stomal closure.


Eligibility criteria:
inclusion criteria: * patients \> 18 y.o. * stomal closure * elective surgery exclusion criteria: * patients \< 18 y.o. * emergency surgery

Keywords: lateral incisional hernia mesh augmentation prevention stomal closure
adenosine testing to determine the need for pacing therapy

Conditions: Syncope

Summary: the purpose of this study is to determine whether or not the intravenous adenosine test readily identifies patients with unexplained syncope who would benefit from permanent pacemaker implantation.

the investigation of syncope (transient loss of consciousness with loss of postural tone, collapse and spontaneous recovery) varies widely, is often lengthy and frequently expensive. the intravenous adenosine test has been used in the investigation of syncope and is cheap, safe and free of serious side effects. however, it is unclear what diagnosis the test unearths. there is some evidence that the test readily identifies bradycardia pacing indications. in this study we plan to perform the adenosine test and implant a pacemaker should the test be positive. in half of the patients we will turn the pacemaker "on" and in the other half the pacemaker "off". the groups will swap over after six months. during this time we will assess the number of syncopal episodes. also, in those who have a negative adenosine test we will implant a loop recorder to try to discover the cause of syncope.

Eligibility criteria:
inclusion criteria: * episode of syncope * patient has provided written informed consent for participation in the study prior to any study specific procedures * male or female * age \> 40 years * no cause of syncope clearly identified on clinical examination, lying and standing blood pressure measurements and standard 12 lead ecg. exclusion criteria: * asthma or chronic obstructive pulmonary disease * severe coronary disease (myocardial infarction within 3 months, known coronary stenosis \>70%, nyha heart failure or angina symptoms class iii or iv) * known severe cerebrovascular disease or known significant internal carotid artery stenosis (\>70%) * prolonged corrected qt interval * unablated accessory pathway * pregnancy or lactation * use of dipyridamole or any rate-limiting medication that cannot be safely discontinued * hypertrophic cardiomyopathy * cardiac transplantation * concurrent participation in another investigational study or trial * inability to give informed consent; carer/proxy assent will be allowed in this study * cause of syncope established from initial clinical history and examination, lying and standing blood pressure and ecg
echocardiographic standards and sub-saharian africans (ssa) migrants' in new aquitaine region

Conditions: Diagnosis

Summary: standards echocardiographic have been defined mainly on caucasian or asian populations. in the echonormal study the criteria for african populations were based solely on data from 198 subjects. this study suggests the presence of different standards depending on the ethnic origin of the subjects. the aims of this study is to describe the proportion of subjects reclassified (normal-pathological) according to the use of echocardiographic norm differences showed in tahes population (sub saharian africans) with those routinely used

sub-saharian africans populations seem to be more vulnerable in the field of health in general and in cardiovascular pathologies in particular. * the echocardiographic standards were mainly defined for caucasian or asian populations (echonormal col. 2014 and 2015). in the echonormal study, the criteria for the african populations were based on a reduced workforce (data from 198 subjects). * this study suggests the presence of different standards depending on the ethnic origin of the subjects. the authors noted that the establishment of references according to the ethnic origin of the subjects is necessary and highlighted the need for additional study for the underrepresented groups, in particular those including subjects of african origin. the need for different ecg standards in african subjects, was confirmed in a study in the general african population (tahes), represents 16% of immigrants in 2015 (insee according to reports from the health insurance funds, the migrant population,

Eligibility criteria:
inclusion criteria: - ssa major subjects (first generation or from or from first generation parents) admitted to the hospital for an echocardiography exclusion criteria: * participation refusal; * any acute heart disease (endocarditis, myocarditis, coronary syndrome); * valvulopathy justifying an intervention; * diseases of overload. * any acute heart disease (endocarditis, myocarditis, coronary syndrome); * valvulopathy justifying an intervention; * diseases of overload. * both participant and accompanying person unable to understand the information note written in french and in english

Keywords: echocardiography, diagnosis
management of soil-transmitted helminthiasis and strongyloidiasis

Conditions: Helminthiasis; Strongyloides Stercoralis Infection

Summary: the general purpose of the project is to analyse soil-transmitted helminthiases (sth) in a highly endemic area in northern argentina with a multidisciplinary approach. the specific objectives are to evaluate the local epidemiology of sth, validate a new diagnostic serology method for s. stercoralis and evaluate the efficacy and safety of a mass drug administration regimen with albendazole and ivermectin.


Eligibility criteria:
inclusion criteria: * all persons that are living in the working area at the time of the intervention and wish to participate in the study. exclusion criteria: 1. all persons that live within the study area but do not want to participate in the study. 2. pregnant women or women who are likely pregnant. 3. women during the first post-partum week if they are breastfeeding. 4. children who weigh less than 15 kg. 5. persons with a history of hypersensitivity or intolerance to ivermectin, albendazole or to the components that make up those drugs.

Keywords: sth soil-transmitted helminthiasis mass drug administration
a prospective, cohort study of hyperpolarized 3he mri in chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: the purpose of this study is to determine the mri characteristics of chronic obstructive pulmonary disease subjects both at baseline and yearly for a period of 5 years, and to correlate these biomarkers with pulmonary function tests, ct scan, 6 minute-walk tests, and respiratory questionnaires. the central hypothesis is that quantitative assessment of the lung through magnetic resonance imaging of hyperpolarized 3he can detect early alterations in structure and function which are precursors to clinically apparent copd and that these precursors can be used to predict progression of disease earlier and better than established clinical methods. novel assessments using 3he mri will lead to new information about copd and will be critical for characterizing disease response to therapy. a secondary hypothesis is that a variety of technical improvements in the techniques of hyperpolarized gas mri will accelerate the translation of this relatively new modality to clinical use.


Eligibility criteria:
inclusion criteria: * written informed consent was obtained and documented (after the investigator has given oral and written information about the study to the subject). * the subject was conscious, co-operative, and agreed to return for the scheduled visits and tests and any visits required to obtain additional safety information. * the subject's medical history, physical examination (including vital signs, pulse oximetry, pft's, and 12-lead electrocardiogram \[ecg\]), and clinical laboratory tests (hematology, serum chemistry) obtained at the screening visit were within acceptable limits for entry into the study, as judged by the investigator. exclusion criteria: * subject is \ 70 years old * subject known to be pregnant * subject with a baseline oxygen requirement \> 2 l/min via nasal cannula * any known contraindication to mri examination * inability to provide informed consent * a language, communication, cognitive or behavioral impairment that might interfere with fully informed consent * active drug or alcohol dependence * homelessness or other unstable living situation * active drug or alcohol dependence * significant co-morbidities such as heart disease, kidney disease, liver disease, hematologic or neurological disease that require continuing treatment.
yervoy® risk minimization tool effectiveness evaluation survey

Conditions: Advanced Melanoma

Summary: to evaluate the effectiveness of the yervoy® educational risk minimization (rm) tools in terms of awareness about these tools, their utilization, knowledge and comprehension of immune related adverse reaction (irar)s, and appropriate behavior by healthcare professional (hcp)s and patients

a total sample size of 160 to 200 hcps and 160 to 200 patients

Eligibility criteria:
for more information regarding bms clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * hcp experienced in the treatment of patients with the research compound and patients that have received at least one dose
a trial of hrs-1893 in patients with obstructive hypertrophic cardiomyopathy

Conditions: Obstructive Hypertrophic Cardiomyopathy

Summary: the study is being conducted to evaluate the efficacy, and safety of hrs-1893 for obstructive hypertrophic cardiomyopathy


Eligibility criteria:
inclusion criteria: 1. age 18-85 years old, gender unlimited; 2. the diagnosis was obstructive hypertrophic cardiomyopathy. 3. echocardiographic laboratory tests showed lvef≥60%; 4. no previous left ventricular systolic dysfunction at any time (lvef \< 45%); 5. understand the study procedure and sign the informed consent in person, willing to strictly follow the clinical study protocol to complete the study. exclusion criteria: 1. known or suspected invasive, genetic or storage diseases (e.g. noonan syndrome, fabre's disease, amyloidosis) that cause cardiac hypertrophy (similar to ohcm); 2. previous left ventricular systolic dysfunction at any time in the clinical course (lvef \< 45%); 3. previous history of aortic stenosis or subaortic fixed stenosis;
a postoperative sore throat after thyroidectomy

Conditions: Post Operative Sore Throat

Summary: this study was performed to compare the effect on of a postoperative sore throat between dexmedetomidine and remifentanil in patients undergoing thyroidectomy.


Eligibility criteria:
inclusion criteria: * patients who scheduled primary thyroidectomy were enrolled and their physical status was american society of anesthesiologists (asa) class 1 or 2 exclusion criteria: * patients with respiratory tract disease, previous head, and neck surgery, preexisting steroid or non-steroidal anti-inflammatory drug use, and known or suspected difficult airway

Keywords: postoperative sore throat dexmedetomidine remifentanil thyroidectomy
evaluation of root coverage by connective graft and different root conditioning adjunctive therapies

Conditions: Gingival Recession; Gingival Recession, Generalized

Summary: the aim of this study was to evaluate the effect of two different treatment agents used in conjunction with subepithelial connective graft technique on root coverage outcomes in multiple recession defects. half of patients will receive root treatment with antimicrobial photodynamic therapy and the other half will receive photobiomodulation therapy by laser on surgery site.

antimicrobial photodynamic therapy has been widely used in periodontics to obtain reduction of periodontopathogenic bacteria with absence of systemic side effects and minimal bacterial resistance. also, it has properties of root demineralization and exposure of collagen fibers. these properties may enhance root coverage in procedures of subepithelial connective graft. laser photobiomodulation has the potential to increase healing and repair, this can generate gains in the root coverage and dental hypersensitivity.

Eligibility criteria:
inclusion criteria: * multiple gingival recession - two or more miller's class i or ii (2 to 5 mm of height) * indication of root coverage by dentin hypersensitivity or esthetic. * minimum palate thickness (1,5mm) * visible enamel cement junction (jce) on the teeth to be treated and pulp vitality * patients without signs of periodontal disease activity and with plaque index and bleeding on probing throughout ≤20%; exclusion criteria: * use of drugs that affect periodontal tissues (eg: anticonvulsants, calcium channel blockers, cyclosporine, bisphosphonates, hormone-based contraceptives, steroids) * smokers * pregnancy * diabetics * history of head and neck radiotherapy * teeth with mobility * malpositioned teeth * history of periodontal surgery at the area on the last 12 months * patients with orthodontic therapy in progression
nivolumab for relapsed or residual haematological malignancies after allogeneic stem cell transplantation

Conditions: Haematological Malignancy

Summary: this is a prospective study of the safety and efficacy of nivolumab for the treatment of relapsed or residual haematological malignancies after allogeneic stem cell transplantation (allosct). eligible patients will receive nivolumab at a dose of 3mg/kg intravenously every 2 weeks. the primary objective is to evaluate the incidence, severity and treatment responsiveness of gvhd following nivolumab treatment post-allosct.


Eligibility criteria:
inclusion criteria: * prior allogeneic stem cell transplant for a haematological malignancy * confirmed relapse of haematological malignancy or persistent disease post-allosct * immunosuppression cessation for minimum of 2 weeks * life expectancy \> 2 months * ecog performance status 0-2 * greater than or equal to 30% cd3+ donor chimerism * serum creatinine ≤ 1.5 times upper limit of normal or creatinine clearance ≥ 40ml/min * ast and alt ≤ 3 times upper limit of normal * total bilirubin ≤ 1.5 times upper limit of normal (except patients with gilbert syndrome) * signed written informed consent exclusion criteria: * current evidence of any grade of gvhd * prior history of grade 2 or higher acute gvhd * moderate chronic gvhd within the previous 6 months or any prior history of severe chronic gvhd * active, known or suspected autoimmune disease (excluding vitiligo, type 1 diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger) * positive hepatitis b virus surface antigen * positive hepatitis c virus antibody * known human immunodeficiency virus infection
left bundle branch area pacing using conventional stylet-driven pacemaker leads for cardiac resynchronization therapy

Conditions: Heart Failure with Reduced Ejection Fraction

Summary: the aim of this study proposal is to compare the effectiveness of two distinct pacing modalities for cardiac resynchronization therapy. our primary hypothesis is that left bundle branch area pacing (lbbap) using conventional stylet driven pacemaker leads is an effective resynchronization method that yield to at least similar clinical benefits and outcomes when compare to biventricular pacing.

recently some retrospective or uncontrolled studies were published that compared cardiac resynchronization therapy (crt) using left bundle branch area pacing (lbbap) and biventricular pacing (biv), although with a limited number of patients. moreover, only one of these studies compared lbbap + right ventricle stimulation to conventional biv stimulation prospectively. none of the studies used conventional stylet-driven pacemaker leads for lbbap. therefore, the present trial aims to fill-in the gap in the current literature regarding lbbap for crt and provide a first randomized head-to-head comparison against crt. the aim of this study proposal is to compare the effectiveness of two distinct pacing modalities for cardiac resynchronization therapy. our primary hypothesis is that left bundle branch area pacing (lbbap) using conventional stylet driven pacemaker leads is an effective resynchronization method that yields to at least similar clinical benefits and outcomes when compared to biventricular pacing. the study is a multicentre, randomized trial comparing lbbap against biventricular pacing. after characterization of the type device implanted (pacing or defibrillator), randomization will occur between both groups in a 1:1 ratio. the trial purpose is to demonstrate the efficacy of lbbap to treat clinical heart failure in-patient indicated to receive a crt.

Eligibility criteria:
inclusion criteria: * aged 18 or above * left ventricular ejection fraction (lvef) and nyha meeting one off the previous indications documented with transthoracic echocardiography (tte) no later than 3 months before randomization. * new york heart association (nyha) class ii-iv * baseline left bundle branch block and qrs \&amp;amp;gt;130ms or qrs \&amp;amp;gt;150ms of any morphology or a wide paced qrs duration. exclusion criteria: * younger than 18 years old * pregnancy * any unstable medical condition, life expectancy \&amp;amp;lt; 12 months * inability to provide consent or to undergo follow-up * narrow qrs duration (≤130ms) or prolonged qrs duration with typical right bundle branch block (rbbb) morphology on 12 lead ecg and sinus rhythm. * significant hypertrophic cardiomyopathy - any septum abnormality contra-indicating lbbap implantation (according to physician's evaluation) * patients who are unable to perform a 6 minute walk test (6mwt) note: patients should be able to perform a 6 minute walk test, but it is not a requirement to have the test performed before the procedure (e.g. due to inability of planning).
effect of virtual reality on pain, arterial blood gases and functional capacity in children after open heart surgery

Conditions: Children After Open Heart Surgery

Summary: this study will be conducted to investigate: * the effect of virtual reality on pain in children after open heart surgery, * the effect of virtual reality on arterial blood gases in children after open heart surgery, * the effect of virtual reality on functional capacity in children after open heart surgery.


Eligibility criteria:
inclusion criteria: * both genders will be included. * their age range from 6 to 12 years. * children after open heart surgery ( phase i cardiac rehabilitation). exclusion criteria: the children have one or more of the following will be excluded: * any child suffering from any other chronic congenital diseases. * severe visual or auditory problems. * neurological problems. * vertigo problems. * post surgical hemorrhage. * post surgical arrhythmia.

Keywords: virtual reality, heart surgery