Kornimate/medical-research-clean huggingface dataset:
sleep quality among hcws

Conditions: Sleep Quality

Summary: the novel coronavirus has brought the world into uncharted waters. whole countries are on lockdown, the economy has ground to a halt, and many people are afraid for themselves and their loved ones. with such unprecedented changes coming on so quickly, it's understandable that the importance of sleep is flying under the radar. but as we adjust to stay-at-home orders and try to remain healthy in a time of covid-19, focusing on sleeping well offers tremendous benefits. millions of people suffered from insomnia before the coronavirus, and unfortunately, the pandemic creates a host of new challenges even for people who previously had no sleeping problems. the coronavirus pandemic doesn't affect everyone in the same way. of course, patients with the virus and front-line medical workers face the brunt of the direct impacts of the disease. social distancing, school closures, quarantines, working-from-home: all bring profound changes to normal routines for people of all ages and walks of life. the aim of the current work is to assess the sleep quality among health care workers in the front-line management of covid-19 in kuwaiti ministry of health hospitals and its relation on medical errors.


Eligibility criteria:
inclusion criteria: -health care workers at kuwait ministry of health hospitals during the period from may 2020 to july 2020 exclusion criteria: * care givers above 60 years * those who refuse to participate or requested to withdraw from the study at any time * hcws who were not on duty at the time of survey due to any leave or absence * replies with incomplete answers or duplicate answers
determination of perioperative acute kidney injury incidence

Conditions: Intensive Care Unit Syndrome

Summary: in the last few years, acute renal injury (aki) definition has been significantly changed. in the light of the data obtained from multicenter international studies, acute renal injury was redefined according to rifle, akin and kdigo criteria. the common criteria of all three criteria in acute renal failure is the increment of level of creatinine as 0.3 mg/dl or 50 % increment of respective basal value of serum creatinine. in the current study, older than 40 years patients with no specific gender, who will stay at least one night in hospital will be included and cardiovascular and urological surgery patients and patients with known renal insufficiency will be excluded. it was aimed to measure serum creatinine levels in all included patients at baseline and up to 24h after surgery and will be determined acute kidney injury incidence and risk factors according to new criteria.


Eligibility criteria:
inclusion criteria: * older than 40 years * no gender specified * patients who will stay at least one night in hospital * patient with normal renal function exclusion criteria: * patient with renal dysfunction and cardiovascular, urological surgery patients

Keywords: acute kidney injury surgery perioperative care
study to evaluate the safety, efficacy of tegoprazan for the prevention of pud in patients on treatment with nsaids

Conditions: Preventive Peptic Ulcer

Summary: this study is designed to confirm the non-inferiority of tegoprazan 25 mg, compared to lansoprazole 15 mg, to prevent gastroduodenal ulcers and verify the safety of tegoprazan following oral administration of tegoprazan 25 mg qd or lansoprazole 15 mg qd in patients on long-term treatment with nsaids.

this is a double-blind, randomized, active-controlled, phase 3 study. subjects will be randomly assigned to one of the two treatment groups (tegoprazan 25 mg, lansoprazole 15 mg).

Eligibility criteria:
inclusion criteria: * ≥60 years of age, or ≥20 years of age with a history of gastroduodenal ulcers (gastric and/or duodenal ulcers) at screening * requires continued treatment with nsaids for ≥24 weeks exclusion criteria: * has an active stage (a1, a2) or healing stage (h1, h2) of gastroduodenal ulcers per the sakita-miwa classification identified by upper gi endoscopy at screening * has uncontrolled severe hypertension * has severe heart failure, congestive heart failure (nyha ⅱ to ⅳ), ischemic heart disease (unstable angina, myocardial infarction), or peripheral artery disease, or has undergone coronary artery bypass graft (cabg) who is considered ineligible for treatment with nsaids * has a positive h. pylori test at screening
the inspire study: investigation of swiss physicians inner-life, resilience, and emotions

Conditions: Burnout, Professional; Emotional Exhaustion; Emotions; Wellness, Psychological; Satisfaction, Personal

Summary: the goal of this clinical trial, nested within an observational cohort study, is to evaluate whether two positive psychology web-based interventions can reduce emotional exhaustion and improve overall well-being in practicing physicians in switzerland. the main questions it aims to answer are: does participation in positive psychology interventions reduce emotional exhaustion at three months post-intervention? how do these interventions impact physician wellness, job satisfaction, comfort with end-of-life communication and other aspects of physicians' emotional well-being? researchers will compare the effects of two intervention arms (general reflection vs. work-specific reflection) to a control group to determine whether focusing on work-specific aspects leads to greater improvements in emotional exhaustion and job-related outcomes. participants will: * complete an 8-day intervention consisting of positive psychology activities delivered online. * complete baseline and follow-up assessments over the study period

burnout, emotional exhaustion, and moral distress are widespread among physicians, negatively impacting patient care, job satisfaction, and physician retention in the workforce. while interventions targeting burnout exist, many require significant time commitments or institutional support, limiting accessibility. positive psychology interventions, which emphasize strengths-based approaches such as self-reflection, gratitude, and self-compassion, have shown promise in enhancing resilience and well-being. the inspire study is a randomized controlled trial (rct) nested within an observational cohort using a trial within cohort (twic) design. it evaluates two web-based positive psychology interventions aimed at reducing emotional exhaustion and improving physician well-being. a subset of cohort participants is randomized into one of three arms: a control group, a general life reflection intervention, or a work-focused reflection intervention. the interventions consist of an 8-day structured self-reflection program delivered online. the study employs automated randomization, triple masking (participants, investigators, and outcome assessors), and longitudinal assessments over one year. findings will inform the scalability of low-burden interventions for physician burnout prevention.

Eligibility criteria:
inclusion criteria: 1. be a practicing physician in switzerland 2. working at least 40% in a clinical capacity 3. be willing and able to provide informed consent 4. expecting to be professionally active until 2028 exclusion criteria: 1. retired physician or physician seeking retirement within 3 years from first participation in the study 2. physician unable to participate in one of the study languages: english, german, or french

Keywords: psychological resilience positive psychology
technology on the occurrence of muscoskeletal disorders in students

Conditions: Pain, Chronic; Posture Disorders in Children

Summary: to investgate the long use of electronic devices that forces the person to adopt an uncomfortable posture which leads to the appearance of musculoskeletal disorders such as neck pain, thoracic pain, back pain and tendonitis of the upper extremities due to writing messages and especially when the person uses only one hand.

due to the uncontrolled use of electronic devices, the purpose of this research is to initially prove that the long-term use of electronic devices is a factor in the occurrence of pain in the musculoskeletal system in students of a '\& b' of high school. a secondary question of the present study is the hypothesis that adopting the wrong posture while using smart devices plays an important role in the onset of symptoms in one or more parts of the body. finally, the third research question of the present study concerns whether long-term use of electronic devices is responsible for reducing physical activity in students. in order to prove the positive correlation between technology and musculoskeletal disorders but also to answer the above questions, a questionnaire was distributed online to one hundred and twenty students of a '\& b' lyceum from all over greece, which was promoted online. more specifically, the questionnaire included questions from two standard questionnaires, the internet addiction test (iat) and the nordic muscuskeletal questionnaire (nqs).in addition they completed a medical history and supplementary questions about their physical condition and the attitudes they adopt when using electronic devices.

Eligibility criteria:
inclusion criteria: * without psychiatric disorders * attended the a \& b high school exclusion criteria: * undergone surgery on the musculoskeletal system

Keywords: musculetical pain electronic device addiction posture
study of omalizumab in moderate to severe bronchial asthma

Conditions: Asthma

Summary: this study will evaluate the safety and efficacy of omalizumab up to 16 weeks in adult patients with moderate to severe bronchial asthma.


Eligibility criteria:
inclusion criteria: * allergic asthma patients * inadequately controlled patients exclusion criteria: * - history of severe anaphylactoid or anaphylactic reactions * previous treatment with omalizumab * history of cancer or cancer other protocol-defined exclusion criteria may apply

Keywords: asthma, ige, omalizumab
group hydrotherapy treatment for athletes with lower back pain

Conditions: Low Back Pain

Summary: the effect of group hydrotherapy on chronic low back pain and function among athletes will be examined.

low back pain is a common issue in western society, especially among athletes who experience significant physical stress. one effective conservative treatment method is hydrotherapy, which involves exercising in water. this approach takes advantage of water's properties, such as buoyancy, weight reduction, and resistance. by using these properties, individuals can perform movements and exercises that may be painful or difficult to do on land. the purpose of the study is to examine the effect of group hydrotherapy on chronic low back pain and function among athletes. the study will involve participants with chronic back pain who will complete a 6-week intervention program led by a certified physiotherapist, including hydrotherapy treatment and guidance for independent exercises. the exercise will include reduced-weight activities at waist-to-neck depth, resistance exercises at varying depths, and the utilization of buoyancy and resistance devices. the evaluation indicators will be taken before and after the intervention period and will include: a demographic questionnaire, history of back pain and anthropometric details (height, weight), oswestry questionnaire to assess function following back pain, a visual analog scale to assess the maximum degree of pain during the day, hip range tests, a forward flexion distance test, and a back alignment test. at the end of the intervention, a global rating of scale questionnaire will also be taken to assess the effectiveness of the improvement.

Eligibility criteria:
inclusion criteria: * athletes who complain of low back pain for over 3 months, * vas\>3 * train more than 5 times a week. exclusion criteria: * acute back pain * neurological signs (decreased muscle strength, decreased reflexes, radiating to the leg).

Keywords: hydrotherapy, low back pain, group, athlete
effect of mannitol on recovery pattern after orthognathic surgery

Conditions: Orthognathic Surgery

Summary: the aim of this study is to test, whether mannitol infusion in different doses will affect recovery pattern? the investigators hypothesized that infusion of mannitol in doses of 0.5 gm/kg before recovery from anesthesia after orthognathic surgery shortens patients' recovery time, and improves recovery quality, as well as postoperative cognitive function better.

the aim of this study is to test, whether mannitol infusion in different doses will affect recovery pattern? the investigators hypothesized that infusion of mannitol in doses of 0.5 gm/kg before recovery from anesthesia after orthognathic surgery shortens patients' recovery time, and improves recovery quality, as well as postoperative cognitive function better methodology this prospective randomized double blinded study will be applied on patients scheduled for orthognathic surgeries as temporo-mandibular joint procedures, le forte ι 0r ii osteotomy, bimax or maxillectomy after ethical committee approval. the selected patients were randomly allocated into two groups each containing 30 patients: * group m: in which mannitol will be given in doses of 0.5 gm/kg 30 minutes before the end of the surgery * group c: similar volume of the infused mannitol but of lactated ringer will be given 30 minutes before the end of the surgery anaesthetic technique: for all patients, atropine sulphate 0.015 mg/kg intramuscular (im) as anti-sialgogue together with dexamethasone 8 mg. hydrocortisone 100 mg and ranitidine 50 mg, will be given iv as pre-medications 15-30 minutes before induction of anaesthesia patient will be transferred to the operating theatre where asa-basic monitors will be applied to the patient (pulse-oxymitery, non-invasive blood pressure, ecg 3-leads and capnography). induction of anesthesia: regular iv induction will be applied for patients with normal mouth opening where difficult intubation is not suspected: fentanyl 2 μg/kg iv, propofol 1 mg/kg iv, atracurium 0.5 mg/kg iv then nasotracheal intubation with armored tube of appropriate size. patients with difficult mouth opening will undergo awake fiberoptic intubation. anesthesia will be maintained by 100% o2 + 1-1.5 mac isoflurane thirty minutes before the end of surgery patients will receive an iv solution which is either mannitol 0.5 gm/kg or lactated ringer.

Eligibility criteria:
inclusion criteria: * age: 18-65 years * asa status i and ii patient. * no contraindication to use of mannitol. exclusion criteria: * asa iii and iv status * extreme of age: paediatric and geriatric patients * severe cardio respiratory, rheumatological or endocrinal disorders * pregnancy and lactation * contraindications to the use of mannitol, e.g. serum osmolality \> 330, renal failure systemic hypertension, proved intra-cranial brain haemorrhage or sub-dural haematoma and hypotension.

Keywords: mannitol recovery orthognathic surgery mandiblular fracture maxillary protrusion
periodontal parameters in orthodontic patients with stainless steel and ceramic brackets.

Conditions: Periodontal Inflammation; Dental Malocclusion

Summary: the aim of this study is to assess if there are significant differences in periodontal conditions between patients undergoing fixed orthodontic treatment with stainless steel or ceramic brackets. for this study, patients will be enrolled and divided into two groups, according to the type of brackets (stainless steel or ceramic) used for orthodontic treatment. a professional supragingival and subgingival oral hygiene will be performed before the bonding of the orthodontic brackets together with a periodontal evaluation will be recording the following periodontal indices: ppd, bop, bs, gi, pi, bewe and schiff air index. indices will be recorded after 1, 3 and 6 months after the bonding, separately for both in maxillary and in mandibular dental arches and only for teeth with brackets bonded.

this clinical trial aims to investigate if there are significant differences in periodontal conditions between patients undergoing fixed orthodontic treatment with stainless steel or ceramic brackets. patients recruited for the study will be asked to sign the informed consent. parents will sign the consent for underage patients. a professional supragingival and subgingival oral hygiene will be performed before the bonding of the orthodontic brackets; a piezoelectric instrument and gracey curettes will be used. after that, patients will be divided into two groups: * group met: stainless steel brackets will be bonded on the vestibular surfaces of teeth. * group cer: ceramic brackets will be bonded on the vestibular surfaces of teeth. before the bonding on maxillary dental arch, a periodontal evaluation will be conducted recording the following periodontal indices: ppd, bop, bs, gi, pi, bewe and schiff air index. indices will be recorded after 1, 3 and 6 months after the bonding, separately for both in maxillary and in mandibular dental arches. only teeth with brackets bonded will be considered.

Eligibility criteria:
inclusion criteria: * patients willing to begin fixed multibracket therapy with metallic or ceramic brackets; * full permanent dentition; * all teeth from central incisors to second premolars. exclusion criteria: * patients suffering from systemic diseases; * patients taking medications that could alter periodontal conditions (nsaids, steroids, etc.); * patients with low compliance; * patients unable to give informed consent; * presence of congenital enamel defects; * extractions for orthodontic reasons; * oral/orthognathic surgery; * presence of dental implants on teeth from central incisors to second premolars.

Keywords: orthodontic brackets ceramic brackets stainless steel brackets orthodontic fixed treatment dental hygiene
general anesthesia and paravertebral blocks vs. general anesthesia only: influence inflammation factors and clinical outcomes in modified radical mastectomy

Conditions: Anesthesia, Local; Anesthesia; Inflammatory Response; Pain, Postoperative

Summary: regional anesthesia and analgesia may maintain immune function, reduce surgical stress, and also reduce volatile anesthetics and opioids requirements. local anesthetic drugs used in regional anesthesia and analgesia work to have anti-proliferative and cytotoxic effects on cancer cells. pro-inflammatory cytokines such as il-1, il-6, and tnf-alpha increase in levels in peripheral nerves, spinal cord, brain (brain stem, locus sereleus, thalamus, hippocampus, and prefrontal cortex) after peripheral nerves are injured. the anti-inflammatory cytokine il-10 is decreased in levels after peripheral nerve injury. the balance between pro-inflammatory and anti-inflammatory cytokines affects the severity of pain.


Eligibility criteria:
inclusion criteria: * patient with breast cancer (stadium ia, ib, iia, iib, iiia, iiib) undergoing mrm surgery * balinese race * asa physical status i, ii, iii exclusion criteria: * history of allergy to drugs used in anesthesia * history psychiatric disorder * history of perioperative transfusion * history of autoimmune disease * history of taking beta blockers or anti-platelet aggregation medications * previous breast surgery * spine deformity * coagulopathy * local infections in paravertebral block site * decreased renal function * neurological deficits * peptic ulcer
hetrombopag for pediatric patients with chronic immune thrombocytopenia

Conditions: Immune Thrombocytopenia

Summary: the purpose of this study is to investigate the efficacy, safety of hetrombopag in children with previously treated chronic immune thrombocytopenia who are between 6 and 17 years of age. this is a 2 part study. in part a, patients will receive hetrombopag for 8 weeks. in part b, all patients will receive hetrombopag for 24 weeks.

this is a two-part, double-blind, randomized, placebo-controlled, and open-label phase iii study to investigate the efficacy, safety of hetrombopag in pediatric patients with previously treated chronic itp. in part a, patients will receive hetrombopag for 8 weeks. after completing part a, patients will begin part b, in which they will be randomized to receive hetrombopag or placebo in a 12 week double-blind, placebo-controlled treatment period, following an open-label 12 week treatment period.

Eligibility criteria:
inclusion criteria: 1. age ≥ 6 years old and ≤ 17 years old,both sexes. 2. part a:confirmed diagnosis of itp ≥6months; part b: confirmed diagnosis of itp ≥12months;platelets \<30×10\^9/l twice in a row,and platelets \<30×10\^9/l before taking the medicine. 3. subjects who are refractory or have relapsed after at least one prior itp therapy. 4. birth control during and 28 days after the trial. 5. written informed consent must be obtained from the patient's guardian and accompanying informed assent from the patient (for children over 8 years old). exclusion criteria: 1. no evidence of other causes of thrombocytopenia. 2. diagnosis as evans or wiskott-aldrich comprehensive. 3. patients with any prior history of arterial or venous thrombosis, or diagnosis as thrombophilia. 4. suffering from serious, progressive, uncontrolled kidney, liver, gastrointestinal, endocrine, lung, heart, nervous system, brain, or mental illness. 5. alt, ast, or alp\> 1.5 x upper limit of normal (uln), dbli, or scr \> 1.2 x upper limit of normal (uln). 6. active hiv or hcv-ab positive,hbsag positive. 7. pt result exceeds normal by more than ±3s, aptt result exceeds normal by more than ±10s 8. participated in clinical trials of other drugs (received experimental drugs) within 3 months prior to medication. 9. the inestigators determined that other conditions were inappropriate for participation in this clinical trial.

Keywords: itp
a study of faricimab (ro6867461) in participants with center-involving diabetic macular edema

Conditions: Diabetic Macular Edema

Summary: this is a multiple-center, multiple-dose, randomized, active comparator-controlled, double-masked, three parallel group, 36-week study in participants with center-involving diabetic macular edema (dme). only one eye will be selected as the study eye. where both eyes meet all eligibility criteria, the eye with the worse best corrected visual acuity (bcva) will be defined as the study eye. the study will consist of a treatment period (20 weeks) and an observational period (up to 16 weeks). treatment naive participants will be randomized in a 1:1:1 ratio to one of the arms a, b and c, respectively. participants previously treated with intravitreal (ivt) anti-vascular endothelial growth factor (vegf) will be randomized in a 1:1 ratio to arms a and c.


Eligibility criteria:
inclusion criteria: * macular edema associated with diabetic retinopathy * decreased visual acuity attributable primarily to dme * diagnosis of diabetes mellitus exclusion criteria: * high risk proliferative diabetic retinopathy * cataract surgery within 3 months of baseline, or any other previous intraocular surgery * uncontrolled glaucoma * current or history of ocular disease in the study eye other than dme * major illness or major surgical procedure within 1 month prior to day 1 * uncontrolled blood pressure * glycosylated hemoglobin (hba1c) greater than (\>) 12 percent (%) at screening * untreated diabetes mellitus or initiation of oral anti-diabetic medication or insulin within 4 months prior to day 1