Kornimate/medical-research-clean huggingface dataset:
multiparametric ultrasound for the diagnosis of clinically significant prostate cancer

Conditions: Prostate Carcinoma

Summary: this phase iii trial compares the use of contrast-enhanced multiparametric ultrasound (mp-us) to multiparametric magnetic resonance imaging (mp-mri) for the diagnosis of clinically significant prostate cancer (pca). a mp-us is a procedure in which a probe that sends out high-energy sound waves is inserted into the rectum. the sound waves are bounced off internal tissues or organs and make echoes. the echoes form a picture of body tissue called a sonogram. perflutren lipid michrosphere (definity) is a contrast agent that uses microbubbles to enhance ultrasound images of the prostate. doctors hope to learn if the definity-enhanced mp-us imaging technique can accurately direct targeted biopsy for the detection of clinically significant prostate cancer when compared to standard of care mp-mri.

primary objective: i. to demonstrate non-inferiority between the detection rate of clinically significant pca with 3-dimensional (3d) mp-us + systematic biopsy compared to the detection rate of mp-mri + systematic biopsy. ii. to compare the positive yield of targeted biopsy cores based on mp-us + systematic biopsy with targeted biopsy based on mp-mri + systematic biopsy, for detection of clinically significant pca. secondary objectives: i. to demonstrate non-inferiority of a biopsy approach utilizing targeted biopsy cores based on mp-us compared with targeted biopsy based on mp-mri, for detection of clinically significant pca. ii. to construct an optimal logistic regression model to predict the presence of clinically significant pca based on the mp-us elements as well as the prostate specific antigen (psa), psa velocity and any other biological variables (e.g., age). outline: patients undergo mp-mri, receive definity intravenously (iv), and undergo transrectal mp-us and prostate biopsies on study.

Eligibility criteria:
inclusion criteria: * subject must be scheduled for a prostate biopsy, based on an elevated psa (\> 3.0ng/ml) per most recent national comprehensive cancer network (nccn) guidelines, elevated psa velocity (\> 0.75ng/ml/year), or abnormal digital rectal examination * subject must be able and willing to give written informed consent for a contrast enhanced ultrasound study of the prostate including the additional study biopsies * subject must be a male at least 18 years of age when informed consent is obtained exclusion criteria: * participant in a clinical trial involving an investigational drug within the past 30 days * patients with known or suspected hypersensitivity to perflutren, polyethylene glycol (peg), or any other component of definity * previous treatment for prostate cancer, including hormone therapy * clinically unstable, severely ill, or moribund as per treating physician
abdominal muscles strengthening and pelvic floor muscle strengthening exercises in females with urinary incontinence

Conditions: Urinary Incontinence

Summary: urinary incontinence is common females., it badly affects their performance and result in psychosocial problems in addition to the barriers that already have been resulted from incontinence. this study combines simple regime of hip adductor a strengthening with pelvic floor muscles. the theme is to test if pelvic floor muscle training can be augmented by incorporating adductor muscle strengthening. if this comes out to be effective, this can be great contribution to gym doing females to improve their urinary incontinence related impairments. woman would be encouraged to continue regular exercise. this will be randomized clinical trial. there are two groups for the compression of adductors strengthening and pelvic floor muscle strengthening. the collected data will be entered in spss 20.0, descriptive and inferential statists will be applied. results and conclusion will be drawn.

urinary incontinence is common females., it badly affects their performance and result in psychosocial problems in addition to the barriers that already have been resulted from incontinence. this study combines simple regime of hip adductor a strengthening with pelvic floor muscles. the theme is to test if pelvic floor muscle training can be augmented by incorporating adductor muscle strengthening. if this comes out to be effective, this can be great contribution to gym doing females to improve their urinary incontinence related impairments. woman would be encouraged to continue regular exercise. this will be randomized clinical trial. there are two groups for the compression of adductors strengthening and pelvic floor muscle strengthening. group a: with pelvic floor muscle strengthening is strengthening. group b: abdominal muscles strengthening exercises. the collected data will be entered in spss 20.0, descriptive and inferential statists will be applied. results and conclusion will be drawn.

Eligibility criteria:
inclusion criteria: * women aged 25-45 years of age * females with abdominal muscles weakness * females with pelvic floor muscles weakness * females with urinary incontinence exclusion criteria: * pregnant females * females having any history of trauma * any neurological disorders affecting bowl bladder * any malignancy in lower abdominal area

Keywords: bladder neck mobility
alternative treatments in acute mountain sickness

Conditions: Acute Mountain Sickness

Summary: the purpose of this research is to support a hypothesis that osteopathic manual medicine (omm) and / or a 10 cmh2o end-expiratory pressure (peep) could be used in the prevention of acute mountain sickness (ams). during altitude exposure, an exaggerated hypoxemia and the increase of intracranial pressure are both known to be major physipathological ways of ams development. the goal of the osteopathic protocol is to release tension on the circulatory structures directly related to cranial circulation and drainage. the main hypothesis is that it could lead to lower intracranial pressure and help reducing ams signs. furthermore the investigators would like to define a osteopathic score for individual ams sensitivity, based on cranial bones mobility. several studies have shown that using peep at altitude (or hypoxia) increases spo2. as for osteopathy protocol, the investigators would like to apply this experimental condition during real altitude exposure in a randomized controlled protocol.


Eligibility criteria:
inclusion criteria: * healthy * experienced alpinist * no previous acclimatization exclusion criteria: * heart failure, respiratory failure, kidney failure * pregnant woman

Keywords: altitude acute mountain sickness osteopathy end expiratory pressure
clinical and radiographic outcomes of dental implant therapy

Conditions: Peri-Implantitis

Summary: 900 subjects having received dental implants 9-10 years ago are invited for a clinical and radiographic examination. the individuals were randomly selected from the national health insurance data register in sweden. the clinical and radiographic examination of the 900 selected subjects will include assessments of implant loss, loss of prosthesis and technical / biological complications. biological complications will be assessed from the findings in the clinical and radiographic examinations. thus, signs of pathology in peri-implant tissues, probing pocket depth (ppd) and bleeding/pus on probing (bop) will be recorded. marginal bone loss and other findings in radiographs will also be evaluated. the prevalence, extent and severity of peri-implantitis will hereby be determined. patient-centered outcomes will also be obtained.


Eligibility criteria:
a questionnaire was distributed to the 4716 identified subjects. 3827 questionnaires (81.15%) were returned and, hence, included in the analysis. from the sample of 3827 patients who responded to the questionnaire, 3107 (81.19%) gave their consent for access of patient files/records. patient files/records of 2780 individuals could be collected from the treating dentists (89.48%). out of the 2780, 900 individuals were selected by random sampling, stratifying only for the two age groups. inclusion criteria: * having received implants within the swedish insurance system in 2003/2004. * being in one of the two age groups in 2003: 65-75 years and 45 - 55 years. * having answered the initial questionnaire * treating dentist provided patient files/records exclusion criteria: - having died during the study period (collection of questionnaire and patient files/records)

Keywords: cross-sectional studies prevalence peri-implantitis
validation of the clad score ifor renal colic pain

Conditions: Renal Colic

Summary: renal colic is a frequent reason for recourse representing 1 to 2% of emergency room admissions. this study would validate the performance of the clad score in predicting the need for surgical management within 7 days of patients admitted to the emergency department for renal colic pain.

renal colic is a frequent reason for recourse representing 1 to 2% of emergency room admissions. it results clinically in a lumbo-abdominal pain syndrome radiating into the genitals. the origin of this pain is the tensioning of the urinary tract, most frequently by a lithiasis creating a transient obstruction toulouse medical team has developed the "complicated urolithiasis and alternative diagnosis" (clad) score, which predicts the risk of requiring surgery within 7 days of admission of patients to the emergency room for renal colic the aim of this study is to validate this clad-v score by collecting the elements of the clad score and the clinician's intuition is made available to practitioners in the emergency department. all patients presenting to the emergency room for renal colic pain are eligible. the doctor in charge of the patient will have to examine him and take care of him according to the service protocol. the doctor must then complete the questionnaire provided. a reminder of the patient on d7 is carried out to collect information on the need for surgery after the emergency or not. each center ensures inclusions and reminders on d7 and will only transmit the database

Eligibility criteria:
inclusion criteria: * adult patients admitted to the emergency room for suspected renal colic * patient not objecting to participation exclusion criteria: * patients unable to express their non-objection * pregnant women
12-week efficacy and safety of pregabalin in treating restless legs syndrome (rls) subjects

Conditions: Restless Legs Syndrome

Summary: the purpose of this study is to assess efficacy and safety of pregabalin in treating moderate to severe restless legs syndrome in comparison to placebo.


Eligibility criteria:
inclusion criteria: * idiopathic restless legs syndrome with the presence of all four clinical manifestations of rls: * rls symptoms occur predominantly in the evening * rls history at least 6 months * international restless legs study group rating scale (irls) greater than or equal to 15 at the beginning and the end of placebo run-in * have greater than or equal to 15 nights with rls symptoms in the month prior to screening exclusion criteria: * any secondary rls * current augmentation due to rls treatment * placebo responders identified during the placebo run-in

Keywords: rls
a study to evaluate safety and efficacy of pf-06826647 for moderate to severe plaque psoriasis

Conditions: Psoriasis

Summary: this multicenter study is being conducted to provide additional pf-06826647 safety and tolerability data, and to further explore the clinical efficacy of pf-06826647 in the treatment of moderate to severe plaque psoriasis. additionally, the study is intended to enable selection of oral dose and dosing regimen for the future clinical development of pf-06826647.


Eligibility criteria:
inclusion criteria: * male or female between the ages of 18 and 75 years. * participants with a diagnosis of plaque psoriasis (psoriasis vulgaris) for at least 6 months. * have a pasi score of 12 or greater and a physician global assessment score of 3 (moderate) or 4 (severe). * have plaque-type psoriasis covering at least 10 % of total body surface area (bsa). exclusion criteria: * have non-plaque forms of psoriasis. * drug-induced psoriasis. * current active infection. * infected with mycobacterium tuberculosis (tb). * have any history of malignancies. * require treatment with prohibited concomitant medications(s). * positive for hepatitis b or c, or human immunodeficiency virus (hiv).
the effect of sound stimulation on hearing ability

Conditions: Sensorineural Hearing Loss

Summary: in the late 1990s, researchers discovered that acoustic stimuli slow progressive sensorineural hearing loss and exposure to a moderately augmented acoustic environment can delay the loss of auditory function. in addition, prolonged exposure to an augmented acoustic environment could improve age-related auditory changes. these ameliorative effects were shown in several types of mouse strains, as long as the acoustic environment was provided prior to the occurrence of severe hearing loss. in addition to delaying progressive hearing loss, acoustic stimuli could also protect hearing ability against damage by traumatic noise. in particular, a method called forward sound conditioning (i.e., prior exposure to moderate levels of sound) has been shown to reduce noise-induced hearing impairment in a number of mammalian species, including humans. interestingly, recent report has suggested that low-level sound conditioning also reduces free radical-induced damage to hair cells, increases antioxidant enzyme activity, and reduces cox-2 expression in cochlea, and can enhance cochlear sensitivity. specifically, increased cochlear sensitivity was observed when distortion product otoacoustic emissions (dpoaes) and compound action potentials (caps) were measured. in addition to forward sound conditioning, backward sound conditioning (i.e., the use of acoustic stimuli after exposure to a traumatic noise) has been shown to protect hearing ability against acoustic trauma and to prevent the cortical map reorganization induced by traumatic noise. in this study, the investigators examine the effect of sound stimulation on hearing ability in human subjects.


Eligibility criteria:
inclusion criteria: * male and female * age between 20 and 70 years * subjects should be able to use an mp3 player exclusion criteria: * hearing loss more than 70 db hl at any frequency * more than 10 db of air-bone gaps at more than 3 frequencies in pure-tone audiometry * ear infections, chronic middle ear disease or any abnormality of the ear canal or ear drum * temporary hearing loss * hearing aid user * pregnant females
qol and gi outcomes in malignancies

Conditions: Psychological Adaptation; Psychological Adjustment; Stress, Emotional

Summary: the purpose of this research is to evaluate a new, web-based program among patients with pancreatic cancer aimed at reducing psychosocial stress.


Eligibility criteria:
inclusion criteria: 1. greater than 18 years of age 2. spanish or english speaker with ability to read one of these languages 3. diagnosis of pancreatic cancer . 4. willingness to be assessed at diagnosis, during neoadjuvant chemotherapy (if applicable), preoperatively (if applicable - unless time of diagnosis is preoperative visit), and postoperatively for up to two years following surgery. exclusion criteria: 1. patients unable to read spanish or english, as they will be unable to complete surveys. 2. history of previous invasive cancer or treatment with chemotherapy, as they may have a different baseline functional status, quality of life, and gastrointestinal function compared to the normal healthy population, per principal investigator discretion, based on a case-by-case review. 3. prior inpatient psychiatric treatment for severe mental illness or overt signs of severe psychopathology (e.g., psychosis) within the past six months as these conditions can interfere with adequate participation in assessments, per principal investigator discretion, based on a case-by-case review. 4. have any condition that, in the opinion of the investigator, would compromise the well-being of the patient or the study or prevent the patient from meeting or performing study requirements.

Keywords: psychosocial symptom management ehealth intervention
to determine the efficacy of neurokinin 1 receptor antagonist as a therapeutic tool against cytokine storm and respiratory failure in covid-19 patients

Conditions: Neurokinin 1 Receptor, Substance P, Respiratory Illness, Inflammation, Covid-19, Coronavirus

Summary: this is a randomized, randomized controlled trial to investigate the efficacy and safety of neurokinin-1 receptor (nk-1r) 80 mg orally given daily to treat cytokine storm causing inflammatory lung injury and respiratory failure associated with severe or critical covid-19 infection. nk-1r is the receptor of substance p (sp) and responsible for its functionality. here, we propose that sp via its tachykinin receptor, nk-1r may cause inflammation in covid-19 infection. it may initiate the cytokine storming via binding to its receptor nk-1 and many inflammatory mediators are released. if sp release is reduced by nk-1r antagonist, it may control the cytokine storming and hence the hyper-responsiveness of the respiratory tract through reduction in cytokine storming it may serve as the treatment strategy for covid-19 infected patients. patients fulfilling the inclusion criteria will be enrolled after giving consent. they wll be randomized to treatment with either nk-1r antagonist or placebo in addition to dexamethasone as a standard treatment given to both groups for covid-19 infection as per the protocol at the treating hospital. inflammatory lab markers as detailed should be collected once per day in the morning, preferably at the same time every morning. all enrolled participants will have whole blood collected for whole genome sequencing.

objective: to evaluate the clinical outcomes of neurokinin 1 receptor antagonist in covid-19 patients against the usual treatments as controls dosage aprepitant capsules may be given to patients from 3-5 days fosaprepitant dimeglumine (injection 115mg, prodrug form of aprepitant) may be substituted for oral drug in case of critical patients may be taken with or without food administration one capsule of aprepitant once a day for 3-5 days

Eligibility criteria:
inclusion criteria: * age \> 18 yrs * both genders * lab confirmed covid-19 infection by pcr or plasma positive of specific antibody against covid-19 * in hospital treatment ≥ 72 hours * admitted patients * severe disease (respiratory rate \>=30/min; or (b) rest spo2\<=90%; or (c) pao2/fio2\<=300 mmhg) or * critical phase (respiratory failure and needs mechanical ventilation; or shock occurs; or multiple organ failure and needs icu monitoring) exclusion criteria: * patients who are not willing to give consent * known hiv,hbv, hcv infection * pregnancy

Keywords: neurokinin 1 receptor substance p respiratory illness inflammation covid-19 coronavirus
nivo40-avd for advanced classic hodgkin lymphoma

Conditions: Hodgkin Lymphoma, Adult

Summary: the aim of the current trial is to evaluate the efficacy and safety of flat-dose nivolumab (40 mg) in combination with avd in the management of patients with newly diagnosed advanced classic hodgkin lymphoma

patients will receive 6 cycles of nivo40-avd with interim and eot pet/ct scan. interim pet/ct will not affect clinical decisions and is done as part of the study on response predictors after first line pd-1 inhibitor therapy. in patients achieving only partial metabolic response after 6 cycles (deauville score ≥ 4) radiation therapy is allowed.

Eligibility criteria:
inclusion criteria: 1. newly-diagnosed histologically verified advanced stage (iib-iv as per ghsg) classic hodgkin lymphoma 2. no past history of autoimmune disease 3. age \> 18 years 4. ejection fraction \> 50% 5. ecog 0-4 exclusion criteria: 1. organ failure (e.g. creatinine \> 2x uln; alt or ast \> 5x uln; bilirubin \> 2x uln; hemodynamic instability; respiratory failure \> grade 1) 2. uncontrolled infection 3. pregnancy 4. inability to sign informed consent
physical and work variables in professional musicians

Conditions: Musculoskeletal Pain

Summary: in professional musicians there are characteristic diseases. in this area there is no preventive culture and many musicians end their professional careers due to ailments and pathologies that cause the abandonment of the profession or they learn to live and play with pain. it is a very demanding profession that requires many hours of training without respecting the necessary rest, which undoubtedly produces fatigue and muscle overload, neurological disorders, etc. also, the demands to achieve perfection lead to serious work problems. given that it is a profession that suffers from pain and psychosomatic alterations and that is often accompanied by emotional alterations due to work demands, it is necessary to know this problem and to what extent it affects the musician to be able to act from different areas and improve his well-being. the objective is to know specifically the characteristics of professional musicians, their impact variables, both musculoskeletal and emotional, variables related to the workplace and to evaluate their quality of life.

material and methods subjects. professional orchestral and band musicians between the ages of 18 and 65. study design. descriptive study to be carried out at the university of valencia. to do this, a survey will be carried out through an online platform. all participants will sign the informed consent and the study will be carried out in compliance with the data confidentiality guidelines. to start the study, the approval of the ethics committee of the university of valencia will be necessary and it will be included in an international registry. evaluation. in the first place, the anthropometric data (age, sex, weight, height) and the characteristics of the sample will be taken through an interview designed for this study that will contain questions about the job and instruments they practice. subsequently, the subjects will fill in the assessment instruments that include the physical activity they perform, the musculoskeletal alterations, workplace harassment, professional burnout, quality of life and anxiety and depression. statistic analysis. the variables will be coded and analyzed using the spss v.26 program.

Eligibility criteria:
inclusion criteria: * active professional musicians exclusion criteria: * non-active or non-practicing professional musicians