Kornimate/medical-research-clean huggingface dataset:
effect of bariatric surgery on blood pressure

Conditions: Obesity; Diabetes

Summary: bariatric surgery is generally recommended for obese people with a body mass index (bmi) of at least 40kg/m2, and for people with bmi 35 kg/m2 and serious coexisting medical conditions such as diabetes. a variety of studies showed that it cause significant weight loss, recovery from diabetes and improvement in cardiovascular risk factors, such as blood pressure. the recent guidelines suggest that patients with a bmi of more than 30 kg/m2 with co morbidities is a candidate for bariatric surgery. however, the patients with diabetes in chinese has lower bmi than that in west country. therefore, this research is designed to observe whether bariatric surgery reduce blood pressure in patients with diabetes and relatively lower bmi.


Eligibility criteria:
inclusion criteria: * adults aged between 18 and 60 years old. * type 2 diabetes diagnosis defined according to who 2006 guideline. * body mass index between 25.0 and 39.9 kg/m2. exclusion criteria: * hypertension ≥ 180/120 mmhg; * type 1 diabetes, other types of diabetes or gestational diabetes; * acute complications of diabetes; * cerebrovascular diseases in the last 6 months. * cardiovascular diseases (myocardial infarction, angina, cardiac failure) in the last 6 months. * baseline psychiatric disorders: schizophrenia, bipolar disorder, severe depression, psychosis. * renal diseases: diabetic nephropathy, creatinine clearance \< 30 ml/min. * advanced peripheral arterial disease * atrophic gastritis * alcoholism or use of illicit drugs * previous laparotomy * severe hepatic disorders * pregnancy or women not using effective contraceptive methods. * recent neoplasm (\< 5 years) * immunosuppressant drugs * unable to understanding and follow the study protocol orientations.

Keywords: obesity hypertension bariatric surgery diabetes
siteline 2 polyurethane

Conditions: Bradycardia

Summary: the siteline 2 polyurethane clinical investigation analyzed the safety and electrical performance of the siteline 2 polyurethane pacing lead.

this was a prospective, single-arm, multi-center u.s. clinical investigation, designed to demonstrate the safety and effectiveness of the siteline 2 polyurethane extendable, retractable pacing lead in humans

Eligibility criteria:
inclusion criteria: * patients indicated for dual chamber pulse generator implant, where the pulse generator is capable of meeting the requirements of this investigational protocol * patients selected must have the study lead as the initial implant of a permanent pacing lead in both the right atrium and the right ventricle * age 18 or above, or of legal age to give informed consent specific to state and national law * willing and capable of undergoing a device implant and participating in all testing associated with this clinical investigation * available for follow-up at an approved clinical investigational center, at the protocol-defined intervals * a life expectancy of more than 180 days exclusion criteria: * have or who are likely to receive a mechanical tricuspid valve during the course of the clinical investigation * have surgically uncorrected primary valvular heart disease * have an atrial tachyarrhythmia that is permanent (i.e., does not terminate spontaneously and cannot be terminated with medical intervention) or persistent (i.e., can be terminated with medical intervention, but does not terminate spontaneously) * requiring icd therapy * have a hypersensitivity to a nominal single dose of 1.0 mg (0.5 mg per electrode) of dexamethasone acetate drug * enrolled in any concurrent study, including drug investigation, without guidant written approval, that may confound the results of this study * women who are pregnant or plan to become pregnant

Keywords: pacemaker leads electrodes, implantable cardiac pacing, aritificial
pelvic floor muscles and stabilization integrated training improved pregnancy-related pelvic girdle pain

Conditions: Pelvic Girdle Pain

Summary: pregnancy-related pelvic girdle pain (ppgp) is a common musculoskeletal problem for women during pregnancy and after delivery. the main purpose of this study was to investigate the effects of integrated training for pelvic floor muscles (pfms) and stabilization with and without transabdominal ultrasonography (taus) imaging-guided biofeedback on pain, disability, and physical function, and muscle functions for the abdominal muscles and pfms in postpartum women with ppgp.

many women have pregnancy-related pelvic girdle pain (ppgp), and about 30% with ppgp women still complain of pain after 1-year postpartum. both physical and mental functions of ppgp women are impaired. pelvic stabilization exercise with pelvic floor muscle training is believed to be effective for reducing pain and improved pelvic stability. however, intervention studies on ppgp women is limited and current evidence are controversial. incorrect pelvic floor muscle activations may be partly contributed to these results. one previous study has showed about 60% of women cannot activate pelvic floor muscles correctly. transabdominal sonography-guided biofeedback by observing bladder movements is no-invasive and benefit learning correct muscle contraction. therefore, the main purposes for this study are to investigate the effects of pelvic stabilization training using transabdominal sonography-guided biofeedback in postpartum women with ppgp. a total of 50 postpartum ppgp women will be randomized into one of the two groups: (1) biofeedback group, (2) exercise group, (3) control group, and (4) health group. subjects in the biofeedback group and exercise group will perform the same exercise training for 8 weeks except the subjects in the biofeedback group will receive transabdominal sonography-guided biofeedback of bladder movement for the first 4 weeks. the outcome assessment will include the muscle thickness of abdominal muscle and pelvic floor muscle control, functional performance of aslr fatigue task, timed up and go and fast walking, pelvic girdle questionnaire (pgq), and numeric rating scale (nrs). it is anticipated that the biofeedback group will have more improvements that the exercise group.

Eligibility criteria:
inclusion criteria: * postpartum : ≥ 3 months * pregnancy-related pelvic pain * pain location is located between posterior iliac crest and gluteal fold * clinical screening test for pelvic pain: aslr : positive and si joint ≥ 2 (+ symphysis ≥ 1) exclusion criteria: * lumbar or pelvic surgery * lother causes of pelvic pain (such as fractures) * lradiculopathy * lother health problems, such as cancer, cardiovascular disease, rheumatism , etc * ldaily activities limited , unable to complete the experiment * lcommunication disorders * lmental disorder * lpregnancy * lhave been trained in stable muscle strength in the past.

Keywords: pregnancy-related pelvic girdle pain postpartum women pelvic stabilization exercise pelvic floor muscles ultrasonography imaging biofeedback
functional decline and qol in people aging with hiv in asia

Conditions: Frailty; Disability Physical; HIV/AIDS

Summary: this is a multi-center prospective cross-sectional study to determine the burden of decline in intrinsic capacity and functional ability, and the prevalence of geriatric syndromes, such as frailty, and disability in adult people living with hiv (plwh) in asia.

this research project is expected to have the following clinical impact 1. to understand the impact of impaired functional status in plwh in asia would be important to determine the long-term health burden needs in this aging population in this part of the world. 2. the identification of risk factors associated with impaired functional status would be important to guide clinical decisions in patient management, such as the choice of anti-retroviral regimen, and screening of and early intervention for modifiable risk factors. these are of paramount importance in the promotion of healthy aging in this population. 3. this proposed cross-sectional study lays the foundation for the establishment of a longitudinal cohort for long-term follow up of people aging with hiv in asia, with the objectives of evaluating the long-term impact of aging on clinical outcomes and functional status in plwh in this region.

Eligibility criteria:
inclusion criteria: * hiv antibody positive * age 35 years or above * asian ethnicity, including but not limited to chinese, malay and indian exclusion criteria: * inability or refusal to consent * active infections requiring in-hospital treatment
reliability and validity of thai calgary depression scale of schizophrenia (cdss)

Conditions: Depression

Summary: depression in patients with schizophrenia is common. several factors was found to be associated with depression including medical illness, quality of life, positive symptoms, and typical antipsychotics. the calgary depression scale of schizophrenia (cdss) is commonly used for screening depression in schizophrenia,however; the thai version of cdss has not been validated. this study aims to a.) test the reliability and validity of the thai version of calgary depression scale of schizophrenia (cdss) and b.) identify the prevalence and factors associated with depression in patients with schizophrenia including quality of life, type of antipsychotic drugs, and severity of schizophrenia in 60 patients with schizophrenia at the faculty of medicine, chiang mai university, thailand.

measurements: the thai version of calgary depression scale of schizophrenia (cdss), positive and negative syndrome scale (panss), hamilton rating scale for depression-17 (ham-d 17), montgomery-asberg depression rating scale (madrs), the thai abbreviated version of world health organization quality of life (whoqol-bref-thai).

Eligibility criteria:
inclusion criteria: * aged 18 years or over * diagnosis of schizophrenia according to dsm-iv-tr exclusion criteria: * having organic brain syndrome * not fluent in thai

Keywords: depression schizophrenia
fluid balance neutralization during crrt (continuous renal replacement therapy)

Conditions: Fluid Overload

Summary: fluid overload is associated with increased mortality in critically ill patients with acute kidney injury. fluid balance controlled is associated with improved outcome in observational studies, and is deemed safe in interventional trials. the objective of the study is to keep fluid balance neutral by matching the net ultrafiltration rate to fluid inputs in patients with vasoplegia, and treated with continuous renal replacement therapy (crrt), while insuring its security using advanced hemodynamic monitoring with continuous cardiac output monitoring.


Eligibility criteria:
inclusion criteria: * patient 18 yo or more, affiliated to a social security system * treated with vasopressors for acute circulatory failure * with kdigo stage 3 acute kidney injury * treated with continuous renal replacement therapy for less than 24 jours * monitored with a calibrated continuous cardiac output device exclusion criteria: * treatment by ecmo (extracorporeal membrane oxygenation) * active hemorrhage necessitating transfusion * maintenance dialysis or renal graft recipient * switch to intermittent hemodialysis is scheduled in the next 72 hours * acute cerebral stroke complicated by coma and under mechanical ventilation * acute fulminant hepatitis * postural maneuver (passive leg raising or trendelenburg) cannot be performed (amputation, inferior vena cava obstruction) * pregnancy or lactating * withdrawal or limitation of care * moribund patient * patient under protective measures/wardship * inclusion in another trial whose main outcome is cumulative fluid balance, or whose intervention targets hemodynamic physiology, fluid balance or net ultrafiltration. * patient previously enrolled in the same study

Keywords: fluid overload fluid balance continuous renal replacement therapy net ultrafiltration acute kidney injury hemodynamic monitoring preload dependence hemodynamic instability acute circulatory failure shock deresuscitation
pain relief in the emergency department waiting room: a prevalence study

Conditions: Acute Pain

Summary: pain in the emergency room is under documented and pain relief suboptimal. data on nurse driven analgesia in emergency department waiting rooms is lacking. the primary objective of this study is to determine the proportion of patients in pain receiving pain therapy administered by the triage nurse (prevalence study). the secondary objectives are to 1) describe nursing practices in analgesia and adherence to the dedicated protocol; 2) to determine the factors associated with the non administration of painkillers and for these factors, to estimate the strength of the association


Eligibility criteria:
inclusion criteria: * documented pain score on arrival by the triage nurse and * patients having to wait in the er waiting room exclusion criteria: * patients directly admitted to the consultation room * patients for whom pain was not recorded
the global angelman syndrome registry

Conditions: Angelman Syndrome

Summary: the global angelman syndrome registry is an online patient organisation driven registry to collect information about the natural history of children and adults with angelman syndrome. the registry will facilitate 1) recruitment for clinical trials into therapies and interventions to benefit participants with angelman syndrome and their families, and 2) advancement of research and best standards of care for angelman syndrome. the registry is currently available in english, spanish, traditional chinese, italian, polish, hindi, and brazilian portuguese.


Eligibility criteria:
inclusion criteria: * diagnosis of angelman syndrome exclusion criteria: -

Keywords: angelman syndrome registries observational study only
prevention of the minor digestive disorders by lactobacillus reuteri supplementation

Conditions: Minor Digestive Disorders

Summary: aim of the study. to evaluate if l. reuteri dsm 17938 supplementation since the first days of life can reduce the onset of gaseous colic in neonates and the onset of minor digestive disorders such as regurgitation and constipation. study design. double blind, randomized, controlled, multicenter study. 492 neonates of 37-42 gestational age, breast or formula fed, will receive l. reuteri 5 drops (1x108 cfu) daily or placebo for 28 days. after the inclusion, at baseline will be performed : * paediatric visit * antropometric valutation * number of the daily crying minutes, number of regurgitation and number of daily evacuation the patients will receive the probiotics/placebo every days for 28 days and the 29th will be repeated the following analyses: * paediatric visit * antropometric valutation * number of daily crying minutes * numbers of regurgitation * numbers of evacuations primary outcome : to define if lactobacillus reuteri supplementation can reduce the onset of gaseous colic, regurgitation and of constipation. inclusion criteria * neonates of 37-42 week gestational age and appropriate birth weight * recruitment age: until 7 days of life * informed consent signed exclusion criteria * presence of other gastrointestinal diseases. * use of fans, aspirin or other drugs * use of antibiotics and/or ppis e/o anti-h2 * participation to other clinical trials


Eligibility criteria:
inclusion criteria: * neonates of 37-42 week gestational age and appropriate birth weight * recruitment age: until 7 days of life * informed consent signed exclusion criteria: * presence of other gastrointestinal diseases. * use of fans, aspirin or other drugs * use of antibiotics and/or ppis e/o anti-h2 * participation to other clinical trials

Keywords: gaseous colic, regurgitation and of constipation
will radiation/chemotherapy treatment of cervical cancer work better with medication that may improve anemia?

Conditions: Anemia; Cervix Neoplasms

Summary: this is a clinical trial (a type of research study) designed to describe the efficacy (effectiveness) and toxicity (safety) of a new medical treatment, nesp (novel erythropoiesis stimulating protein). this study will be offered to patients with cervical cancer undergoing a combination of chemotherapy and radiation. this treatment may lower your red blood cells. the use of nesp may stimulate the body to produce more red blood cells. our hypothesis is that higher red blood cells will be beneficial to the patient during treatment for cervical cancer.


Eligibility criteria:
* consent form completed and signed * hemoglobin between 9-13 g/dl * life expectancy of at least 4 months * karnofsky performance status =/\> 70 * no evidence of hemolysis, gi bleeding, or bleeding due to recent surgery * adequate renal and liver function

Keywords: cervical cancer
transfusion-transmitted cytomegalovirus prevention in neonates

Conditions: Blood Transfusion; Cytomegalovirus Infections

Summary: to evaluate the capacity of intravenously administered cytomegalovirus (cmv)-immune globin (cmvig) to immunize high risk premature infants against cmv infections.

background: premature infants who require multiple blood transfusions have a 15-30 percent incidence of cytomegalovirus infections. many of these infections result in severe disease, with a mortality of about 20 percent. in theory, the infection could be avoided by using blood and blood products exclusively from cmv antibody negative donors. the use of such blood is impractical because it would require the rejection of approximately 40 percent of all blood donors. studies had suggested that passively acquired antibody could reduce the incidence of disease in exposed neonates. this provided the rationale for the use of passive immunization with hyperimmune globin in premature infants likely to require multiple transfusions. lots of high titer cmv immune globulin suitable for intravenous administration were prepared using a technique of screening outdated blood bank plasma for units with high levels of antibody to cmv. design narrative: randomized, double-blind. subjects received either prophylactic cmvig-intravenously or a placebo. infants were followed for up to 12 weeks after discharge. total sample size was expected to be 650. the study completion date listed in this record was inferred from last publication listed in the citations section of this study record.

Eligibility criteria:
neonates at high risk for transfusion-transmitted cmv infection. the neonates were either premature, of low birth weight, or had respiratory distress requiring the presence of an umbilical catheter.
enhancement of neurocognitive functions by hippocampal sparing radiotherapy

Conditions: Radiation of Neurocranial Region

Summary: this randomized trial examines possible enhancements in live quality and neurocognitive functions in patients after radiotherapy of the neurocranial area with hippocampal sparing. although the hippocampus has a crucial role in regard to neurocognition and memory, hippocampal region has been relatively disregarded in radiotherapy of neurocranium so far. brain metastases in the hippocampal region are very rare and an infiltration of the hippocampus by meningioma or by pituitary adenoma just occurs when volume of the tumor is very high. this study aims to reduce the radiation dose in the hippocampal region to improve the quality of live and neurocognitive functions in patients without degrading prognosis or increasing probability of brain metastases in hippocampal region. primary endpoint of the trial is quality of live and neurocognitive functions in patients after radiation of neurocranial region with hippocampal sparing compared with conventional radiotherapy of the neurocranial region without hippocampal sparing. secondary endpoints are cerebral recurrence rate in hippocampal region and overall survival. it is planned to include a total number of 150 patients.


Eligibility criteria:
inclusion criteria: * minimum age 18 * diseases indicating a radiotherapy of neurocranial area (histologically or image-guided confirmed (skull base)meningioma,pituitary adenoma,brain metastases, sclc) * indication for a local radiotherapy in neurocranial area or for a radiation of whole neurocranium * karnofsky-state ≥ 50% * patient has understand content of study protocol * signed study-specific consent form prior to therapy exclusion criteria * pregnant or nursing women * fertile patients who refuse effective contraception during study treatment * persistent drug and/or alcohol abuse * prior radiotherapy of neurocranial region * patients not able or willing to behave according to study protocol * in the case of malignancy: more than 3 brain metastases * in the case of malignancy: brain metastases in hippocampal region or in the hippocampus avoidance zone * gtv in hippocampal region or in the hippocampus avoidance zone * patients in care * patients who are not able to speak german * conditions that preclude the application of mrt (e.g. magnetic implants, cardiac pacemaker) * on-treatment participation on other trials

Keywords: meningioma skull base meningioma pituitary adenoma brain metastases small cell lung carcinoma
effect of laughter yoga on surgical fear and anxiety in patients applied before ureteroscopy

Conditions: Ureteroscopy; Kidney Stones

Summary: surgical fear is a situation where a person experiences excessive fear of surgical procedures. this fear can negatively affect the person's normal life and is usually more intense in the pre-operative period. the causes of surgical fear include factors such as previous negative surgical experiences, lack of sufficient information, post-operative pain and complications. in addition, factors such as age, gender, and level of education can also affect fear. this fear can lead to physical and psychological problems along with stress; symptoms such as increased heart rate, dizziness, and muscle tension can be seen. methods such as cognitive-behavioral therapy, meditation, and hypnosis can be used in the treatment of surgical fear. in addition, anxiety can also arise from thinking about the surgical procedure, post-operative complications, fear of anesthesia, or pain. high-risk surgeries and past negative experiences can increase anxiety. high anxiety before surgery can lead to psychological and physical problems. nurses should offer anxiety-reducing techniques (breathing exercises, relaxation) by taking into account the needs of patients. in addition, having relatives with the patient can help relieve anxiety. laughter yoga is considered an effective complementary therapy to reduce surgical fear and anxiety. developed in india in 1995, this method involves simulating laughter with yoga breathing techniques. laughter yoga relaxes muscles, increases pain threshold, and improves overall psychological well-being. this study aims to evaluate the effects of laughter yoga on patients undergoing ureteroscopy.


Eligibility criteria:
inclusion criteria: it will be applied to patients who agree to participate in the study, are scheduled to undergo ureteroscopy in a urological surgery clinic, have no hearing or vision problems, are over the age of 18, understand and speak turkish, are literate, and can communicate. exclusion criteria: patients with mental retardation and any psychiatric disorder, alcohol or drug addiction, hypertension or heart disease, hernia, glaucoma will be excluded.