Kornimate/medical-research-clean huggingface dataset:
impact of slowly digestible carbohydrates on the gut-brain axis

Conditions: Appetitive Behavior; Obesity; Diabetes Mellitus, Type 2

Summary: our laboratory is investigating the physiological outcomes and health benefits of the consumption of high-quality carbohydrates. one important aspect of the high-quality carbohydrate characteristics is a slow and sustained digestion and glucose release to the blood. in the proposed study, the investigators will evaluate the consumption of different types of slowly digestible carbohydrates (sdcs) and their beneficial effects including moderation of the glycemic response profile (postprandial glycemic response, ppgr) and stimulation of the gut-brain axis, which controls appetite and food intake. this stimulation will be evaluated in terms of second-meal food intake and the circulatory level of appetite-suppressing gut hormones (such as glucagon-like peptide-1).


Eligibility criteria:
inclusion criteria: * bmi 18.5 - 25 kg/m2 * stable weight for the past 3 months (i.e. +/- 2..5 kg) exclusion criteria: * pregnant or nursing women * diabetic * individuals with history of gastrointestinal disease
aldosterone for prediction of post-operative atrial fibrillation

Conditions: Atrial Fibrillation

Summary: post-operative atrial fibrillation (poaf) is a major and frequent complication occurring after cardiac surgery, contributing to prolonged intensive care and hospital stays and is associated with several cardiovascular complications. the exact mechanisms and signaling pathways involved in the development of poaf seem to be multifactorial and remain to date incompletely understood. β-blockers and amiodarone are the first line preventive drugs but are partially effective and near 30% of poaf resist to these strategies. in this context, there is some evidence indicating that renin-angiotensin-aldosterone system and galectin-3 (gal-3) share signaling pathways in the development of cardiac fibrosis and therefore could be very useful predictive biomarkers of poaf and potentially interesting therapeutic target to prevent poaf occurrence. the investigators hypothesis is that preoperative plasma aldosterone levels and galectin-3 (gal-3) expression (in plasma, right atrial appendage or epicardial fat) could be predictive of poaf in patients undergoing elective cabg surgery with preserved lvef.


Eligibility criteria:
inclusion criteria: * patients hospitalized for planned surgical coronary revascularization +/- aortic replacement valve * aged 18 years at least * clinically stable (see criteria for non-inclusion) * with left ventricular ejection fraction preserved (\>50%) exclusion criteria: * patient having already af history * patient with primary hyperaldosteronism * unstable patient defined as any cardiovascular event occurred in the previous 30 days these events are: * hospitalisation for cardiovascular causes * appearance or worsening of symptoms consistent with cardiac failure * appearance or worsening symptoms of coronary * patient refusing participation in the study * patient unable to provide follow-up visits * need for concomitant mitral surgery * emergency cabg * left ventricular ejection fraction (lvef) \< 50% * previous heart surgery * off pump cabg.

Keywords: aldosterone cardiac surgery atrial fibrillation galectin-3 mitochondria ngal acute kidney failure epicardial fat right atrial sample
potential prognostic markers of recovery in post-stroke rehabilitation

Conditions: Ischemic Stroke

Summary: despite increasingly effective early treatment strategies for ischemic stroke, post-stroke recovery is often incomplete and depend on spontaneous and therapeutic-induced processes related to neuroplasticity, angiogenesis and reperfusion. these processes are regulated by growth factors, neurotrophines, neurotransmitters, hormones and other factors. this study aims to search biomarkers that prognose brain repair ability and consequently estimate an outcome of stroke patients. the prognostic value of proteins vegf, igf-1 and mmp-9 and expression of genes vegf, igf-1, mmp-9 is evaluated in association with clinical scales including cognitive assessment scales and depression scales. blood sample collection as well as scales recording are taken at baseline and 3 weeks later after rehabilitation.

despite increasingly effective early treatment strategies for ischemic stroke, post-stroke recovery is often incomplete and depend on spontaneous and therapeutic-induced processes related to neuroplasticity, angiogenesis and reperfusion. these processes are regulated by growth factors, neurotrophines, neurotransmitters, hormones and other factors. recovery activity can be reflected both in the clinical assessment of the patient (based on the nihss or mrs scale for example) as well as on the biochemical and molecular level. this study aims to search biomarkers that prognose brain repair ability and consequently estimate an outcome of stroke patients. the prognostic value of proteins vegf, igf-1 and mmp-9 and expression of genes vegf, igf-1, mmp-9 is evaluated in association with clinical scales including cognitive assessment scales and depression scales. furthermore, the collected data will be analyzed in relation to demographics and vascular risk factors. blood sample collection as well as scales recording are taken at baseline and 3 weeks later after rehabilitation. the study group patients will undergo standard post-stroke rehabilitation programme provided by physiotherapist, every day for a period of 3 weeks with weekend gaps.

Eligibility criteria:
inclusion criteria: * subacute ischeamic stroke, * age over 18, * informed consent obtained exclusion criteria: * intracerebral haemorrhage, * chronic or significant acute inflammatory factors, * neurological illness other than ischeamic stroke, * severe cardio-vascular disease like myocardial infarction less than 30 days, unstable angina pectoris, * decompensated metabolic or endocrine diseases

Keywords: stroke recovery biomarker rehabilitation vegf igf-1 mmp-9
study to investigate an immunomodulatory therapy in adult patients with perennial allergic rhinoconjunctivitis

Conditions: Perennial Allergy to House Dust Mite and/or Cat

Summary: the purpose of the study is to test the efficacy of a vaccine against house dust mite and/or cat allergy compared to placebo in adult patients.


Eligibility criteria:
inclusion criteria: * mild to moderate perennial allergic rhinoconjunctivitis due to hypersensitization towards house dust mite and/or cat allergens exclusion criteria: * clinical relevant other allergies (perennial or seasonal) that could potentially interfere with the patient's study treatment schedule or assessments. * use of any concomitant medication that could affect the patient's study treatment response or assessment results. * any clinically relevant concomitant disease as judged by the investigator. * pregnancy or female planning to become pregnant during the study.
assessment of plaque vulnerability using a novel technique: multi-spectral photoacoustic imaging.

Conditions: Neurology

Summary: identification of intraplaque haemorrhage using mri is technically demanding and sometimes uncomfortable. photoacoustic imaging is a new non-invasive technique combining multi-wavelength infrared laser light and ultrasound imaging, able to discriminate blood and other components in the tissues. the measurement by the multi-spectral photoacoustic imaging is likely to be more acceptable and therefore could replace mri.

a total of 60 patients with stenosis grade of \> 70% and considered for endarterectomy will be recruited for additional imaging. pre-operative pa/us and 3d mr imaging will be conducted. two patient groups are designed to allow performance assessment with respect to anatomy, i.e., penetration depth; one with favourable anatomy (i.e. superficial carotids, proximal plaques and low bifurcation), the other with no anatomical considerations. for in-vivo verification of the morphology and mechanical properties obtained with pa/us imaging, the pre-operative data will be compared to the mr data (imaging-imaging verification). since the patient is operated on, endarterectomy specimens are available for histo-pathological examination and in-vitro testing for verification purposes: the excised tissue will be (snap freeze with liquid nitrogen) transported to tue in eindhoven for in-vitro validation (imaging-histology verification). paris patients will undergo surgery and tissues will be transferred to eindhoven for in vitro mechanical testing. because of the transfer (-80 °c), the rate of success for in vitro testing is expected to be smaller, around 40% (i.e. 12 subjects). nevertheless, the power of the global analysis will be increased.

Eligibility criteria:
inclusion criteria: * presence of at least one carotid plaque with a degree of stenosis 70% (nascet), indication to surgery (endarterectomy), * patients with favourable anatomy criteria : x cranio-caudal length of normal or long neck x cervical adiposity weak or absent x carotid bifurcation in usual situation (at the level of the mandibular angle or lower) x normal genicity of subcutaneous tissues x calcification of arterial moderate or absent * patients affiliated to the social health security system. exclusion criteria: * refusal to participate, * any concomitant chronic condition hampering the realization of ultrasound scanner or mri (allergy to gel, intolerance or contraindication to gadolinium). * unstable patients with plaque claudication inducing procedure acceleration. * patients with unfavourable anatomy criteria : x cranio-caudal length of the neck very short x significant cervical adiposity x carotid bifurcation higher than the mandibular angle x high echogenic subcutaneous tissue x calcification marked arterialh2020-ict-29-2016 no. 731771 ethics requirements x patients with fat necks, presence of extensive calcifications at the site of the stenosis. * patients unable to consent. * pregnant woman or breastfeeding woman

Keywords: carotid stenosis photoacoustic imaging laser diode
pharmacokinetics of sildenafil following administration of an chewable tablet of sildenafil relative to viagra® conventional oral tablet in healthy volunteers

Conditions: Erectile Dysfunction

Summary: this is a single dose open-label comparative pharmacokinetic study to assess the pharmacokinetic characteristics of sildenafil between hip0908 (chewable tablet) and viagra (tablet) in healthy male subjects.


Eligibility criteria:
inclusion criteria: * age between 20 and 45 * weight : over 55kg and 18.5 \< bmi, 25.0 * have to give their consent to participating clinical trial by oneself exclusion criteria: * has a medical history of hypersensitivity to drug including pde5 inhibitor and qtc \> 430ms or uncontrolled arrhythmia

Keywords: anti erectile dysfunction agent
palbociclib in real world practice

Conditions: Advanced Breast Cancer; Metastatic Breast Cancer

Summary: this non-interventional study will describe and analyze the clinical use of palbociclib in routine clinical practice in the treatment of advanced breast cancer.


Eligibility criteria:
inclusion criteria 1. age ≥18 years or older. 2. diagnosis of adenocarcinoma of the breast with evidence of metastatic disease or advanced disease not amenable to treatment with curative intent. 3. documented hr+ (er+ and/or pr+) tumor based on local standards. 4. documented her2- tumor based on local standards. 5. physician has determined that treatment with palbociclib is indicated. 6. evidence of a personally signed and dated informed consent document indicating that the patient has been informed of all pertinent aspects of the study. 7. patients who in the opinion of the investigator are willing and able to comply with regular clinic visits as per standard of care practice at the site. exclusion criteria: 1. patients with a life expectancy of less than 3 months at the time of abc diagnosis, per the investigator's judgment. 2. patients participating in any interventional clinical trial that includes investigational or marketed products at the time of enrollment. (patients participating in other investigator initiated research or nis can be included as long as their standard of care is not altered by the study). 3. patients on active treatment for malignancies other than abc at the time of enrollment. 4. patients who are unable to understand the nature of the study and are unwilling to sign an informed consent. -
post-stroke upper limb rehabilitation using telerehabilitation interactive virtual reality system in the patient's home

Conditions: Stroke

Summary: stroke is a leading cause of death and long-term disability worldwide and its incidence is on the rise. importantly, loss of arm function occurs in up to 85% of stroke survivors, with a significant long-term impact on activities of daily living, leisure activities and work. the capacity for recovery following a stroke depends on several factors, including the extent of the initial neurological damage, spontaneous recovery and rehabilitation, with possible recovery even years after the stroke. unfortunately, accessibility of much needed rehabilitation services poststroke often remains limited, both in terms of intensity and duration, as reported in a recent report on post-stroke rehabilitation services in quebec (richard, 2013) recent evidence suggests that homebased telerehabilitation (tr) is a viable approach for upper limb training post-stroke when rehabilitation services are not available. similarly, the canadian best practice recommendations for stroke care update for 2013 recommends home-based patient monitoring be used when frequent monitoring is needed and face-to-face visits are not available. hence, the investigators have developed and propose to examine the use of a tr system that allows upper limb rehabilitation with ongoing off-line monitoring, to be used after usual poststroke rehabilitation is completed and services are no longer offered.

more specifically, the objective of the proposed study is to assess the impact, in terms of motor recovery, function,quality of life, compliance, safety and cost, of a novel, patient-centered home-based tailored tr program using an affordable virtual reality system for upper-limb rehabilitation post-stroke. such a system, combined with remote off-line monitoring could allow patients to take charge and pursue their rehabilitation beyond current services, maximizing their potential for recovery. a single-blind two-arm randomized clinical trial (rct) is proposed for this study with participants who have had a stroke randomly allocated to: (1) 4-week training with home-based tele-rehabilitation (tr) system (see intervention below).i.e. treatment group or (2) 4-week written home exercise program provided by a clinician, i.e. exercise control group.

Eligibility criteria:
inclusion criteria: * ischemic or hemorrhagic stroke (does not have to be a first time stroke); * mild to moderate upper limb impairment (score 3-6 chedoke-mcmaster arm component or ability to perform vr tasks at least at the lowest setting according to clinician); * at least 6 months post stroke; * no longer receiving rehabilitation services; and (5) living in an area where high speed internet access is available. exclusion criteria: * being medically unstable; * severe cognitive or communication deficits; * visual impairments; * severe balance deficits limiting sitting safely independently; * shoulder pain; * previous upper limb impairment limiting potential recovery.

Keywords: virtual reality telerehabilitation stroke rehabilitation
sleep and cerebral responses to high altitude

Conditions: Acute Mountain Sickness; High Altitude Pulmonary Edema; High Altitude Cerebral Edema

Summary: mechanisms underlying high-altitude intolerance as well as exercise performance limitation in hypoxia still remain to be fully understood. recent data suggest that sleep disturbances on one hand and cerebral perturbations on teh other hand may be key mechanisms. the investigators evaluated 12 healthy subjects at sea level and at 4400 m of altitude for 7 days in order to better describe sleep and cerebral responses. the investigators hypothesized that sleep and cerebral disturbances play a critical role for the developement of acute mountain sickness and for exercise performance limitation during acute high-altitude exposure.


Eligibility criteria:
inclusion criteria: * 18 to 50 yrs old * male exclusion criteria: * respiratory, cardiac, metabolic or neuromuscular diseases * history of severe acute mountain sickness

Keywords: hypoxia exercise sleep brain neuromuscular function heart
longitudinal innate immunity and aging study

Conditions: Healthy Older Adults Ages 60-89

Summary: this study plans to examine biological bases of cognitive aging. the goals of the study are to better understand how immune system markers, measured in the blood and in the spinal fluid, are related to clinical features of aging over time. the study also aims to better understand how different types of biomarkers may relate to immune health and the aging process. this research may ultimately help us better understand what puts individuals at risk for cognitive decline and for alzheimer's disease.


Eligibility criteria:
inclusion criteria: 1. between ages of 60-89 2. have a reliable study partner who has frequent contact with the subject (i.e., at least twice per month) and is able to provide information about functional abilities 3. mini mental state examination (mmse) \>23 4. clinical dementia rating (cdr) global score of 0 5. no informant report of significant cognitive decline in prior year 6. no evidence from the screening visit suggesting a neurodegenerative disorder (per team neurologist) 7. willingness to complete both baseline and 2-year follow-up procedures exclusion criteria: 1. major psychiatric disorder (e.g. schizophrenia, bipolar disorder, untreated major depression within past year) 2. neurological conditions affecting cognition (e.g. parkinson's disease, epilepsy (onset prior than 2 years ago), head trauma with loss of consciousness \>5 min within past two years, large vessel infarct, mild cognitive impairment, or dementia) 3. cns immune conditions and other conditions affecting cognition (e.g., multiple sclerosis, paraneoplastic encephalitides; hashimoto's encephalopathy; systematic lupus erythematosus) 4. systematic illness (e.g.,current cancer, renal failure, respiratory failure) 5. substance abuse/dependence (dsm-v criteria) 6. current medication use likely to affect cns (e.g., long-acting benzodiazepines, neuroleptics in the phenothiazine and haloperidol families) 7. current medication use that precludes lumbar punctures (e.g. anticoagulants, antiplatelets, heparin shots, or some other blood thinner medications: warfarin \[coumadin\], pradaxa \[dabigatran\], xarelto \[rivaroxaban\]. eliquis \[apixaban\], or plavix \[clopidogrel\]. 8. significant sensory or motor deficits that would interfere with cognitive testing 9. factors that preclude mr imaging (e.g., pacemaker) 10. factors that preclude lumbar puncture

Keywords: alzheimer's disease dementia older adult covid-19 sars-cov-2
viscosupplementation in the hip following hip arthroscopy

Conditions: Osteoarthritis

Summary: hip arthroscopy is a rapidly evolving procedure that has seen an exponential increase in the number of cases performed yearly. with hip arthroscopy still in its infancy in relation to knee and shoulder arthroscopy, there are still many questions yet to be answered. axioms that were once thought to be true regarding indications and treatment for hip arthroscopy are continually being revised. as with the knee and shoulder before it, the hip is now graduating into treatment avenues that were otherwise thought to only be possible through an open surgical procedure. viscosupplementation in patients post arthroscopy with known articular cartilage injury has been shown to be efficacious. the pathophysiology of hyaline degradation during the arthritic process within the knee has been studied, and with this understanding has grown the widespread usage of viscosupplementation. while questions still exist regarding the effectiveness of viscosupplementation in non-weightbearing joints, it appears the benefits seen in the weight bearing joints, such as the knee, are apparent


Eligibility criteria:
inclusion criteria: preoperative inclusion criteria will be made via x-ray and mri evaluation. these criteria shall include: 2 mm or greater joint space preservation of the hip on radiographs, absence of acetabular subcortical bone cysts, tonnis score less than 2 on radiographs, and patient age greater than 18.4 intra-operative evaluation of the cartilage will be performed by the surgeon on both the acetabular and femoral head sides. patients shall be included if the osteochondral defect meets outerbridge classification criteria of stage ii or greater. furthermore the lesion shall be greater than 1cm in size (and thus not amenable to other procedures such as microfracture). subjects must be willing to sign the irb-approved informed consent and be older than 18 years old. exclusion criteria: all patients 55 years of age and older. all patients with previous hip surgery on a concomitant side. patients who present a history of radiculopathy or regional pain syndrome. patients with a worker's compensation claim or pending litigation claim. patients with outerbridge grade iv changes on either acetabular or femoral articular cartilage.
efficacy of standardized-propolis extract (epp-af®) gel formulation as buccal antiseptic

Conditions: Candidiasis, Oral; Stomatitis, Denture

Summary: the purpose of this study is to evaluate the efficacy and safety of propolis on the treatment of oral candidiasis, more specifically denture stomatitis. half of participants will receive a standardized-propolis (epp-af®) gel formulation while the other half will receive miconazole gel, both for oral use.


Eligibility criteria:
inclusion criteria: * elderly patients with denture stomatitis exclusion criteria: * recent use of anti fungals or antibiotics(2 months or less), dementia

Keywords: propolis therapeutic miconazole denture stomatitis