Kornimate/medical-research-clean huggingface dataset:
acupressure versus transcutaneous electrical nerve stimulation on pain and quality of life intradialysis

Conditions: Hemodialysis Complication

Summary: hemodialysis patients have a high prevalence of pain, mainly musculoskeletal and intra dialytic pain. a high prevalence of pain was also observed in the upper and lower limbs and the trunk. in addition, severe functional interference of pain in the ability to walk was associated with pain in the upper limb. these results indicate that pain in hemodialysis patients is limiting and disabling (dos santos et al., 2021). acupressure increases relaxation, relieves pain, and reduces anxiety and depression, especially in the elderly. it is relatively inexpensive, safe, non-invasive, and easy to use and is performed by hands, elbows. by applying pressure to specific areas of the body so muscle spasms are relieved, blood circulation and vital energy are improved (bastani et al.,2022). strong non-painful tens within or close to the site of pain produces clinically important reductions in the intensity of pain during or immediately after treatment. with no reports of serious adverse events. tens as an adjunct to core treatment or immediate short-term relief of pain, irrespective of diagnosis. patients should be advised to tailor tens treatment according to their individual needs (johnson et al., 2022).

sixty patients will be randomly assigned into two equal groups (n=30): 1. group a (30 patients) will receive acupressure three times per week for eight weeks. 2. group b (30 patients) will receive tens three times per week for eight weeks.

Eligibility criteria:
inclusion criteria: * • sixty patients with renal failure stage 5 undergoing hemodialysis sessions at least six months ago up to 2 years. * participants with lower limb pain and brief pain inventory (bpi) pain score between 7 and 10 points. * body mass index ranges from 25 to 29.9. * their ages range from 50-60 years old. * all patients will be under full medical control. * patients will be free from lower limb dialysis grafting. * hemoglobin level more than 10 mg\\dl. exclusion criteria: * skin disease such as dermatitis, stitches and wound. * active infection, autoimmune diseases and malignancy. * severe cardiac diseases. * severe chest diseases. * patients with cardiac pacemaker. * epilepsy. * using another integrative treatment method during the study. * uncontrolled diabetes. * deep vein thrombosis. * lumber disc prolapses affect lower limb.
augmented reality for orthognatic surgery patient education

Conditions: Malocclusion; Dentofacial Deformities; Patient Satisfaction; Informed Consent; Patient Education

Summary: to evaluate whether the use of augmented reality (ar) for visualizing 3d models can be a valuable addition to patient education regarding orthognathic procedures compared to using only 2d visualization (on a computer screen).


Eligibility criteria:
inclusion criteria: * patients planned for an orthognathic intake consult in the period of july to april 2024 at the umcu or umcg or uniklinik rtwh aachen; * patients with dentofacial deformity (dysgnathia) including: class ii malocclusion, class iii malocclusion, or open bite; * patients undergoing treatment using bsso (bilateral sagittal split osteotomy), le fort i, or bimax; * the planned treatment is either with or without a genioplasty procedures. * patients 16 years of age or older. exclusion criteria: * patients with craniofacial syndromes, such as cleft lip and palate * patient which require an osteotomy involving two or more segments

Keywords: orthognatic surgery augmented reality patient satisfaction informed consent patient education 3d bsso bimax
effect of nurse-led supportive care on caregiver burden and well-being

Conditions: Nurse-led Supportive Care

Summary: breast cancer is the most common type of cancer in women with a high mortality rate in the world. women may experience many different physiological and psychological symptoms (such as pain, nausea-vomiting, fatigue, stress, anger, and isolation) during diagnosis and treatment process. family members often become caregivers at the time of diagnosis, and treatment of breast cancer patients. therefore, family caregivers experience burden and poor health-related quality of life.

this a pragmatic, parallel group randomized controlled trial aimed that investigating the effect of nurse-led supportive care on caregiver burden and well-being among primary caregivers of women with breast cancer. this trial was conducted in the chemotherapy outpatient clinic of training and research hospital located in turkey. all primary caregivers were family members.

Eligibility criteria:
inclusion criteria: * being the primary caregiver of breast cancer patients * literate * able to understand and complete the questionnaires * willingness to participate in the study exclusion criteria: * having communication problems * having psychological diseases * receiving any supportive care

Keywords: breast cancer caregiver burden well-being nurse-led care
a phase 1 study of esg206 in adult subjects with b-cell lymphoid malignancies

Conditions: B-cell Lymphoid Malignancies

Summary: this is a phase i, multicenter, open label, sequential-cohort, dose escalation study of esg206. the purpose is to evaluate the clinical safety, tolerability, pk (pharmacokinetics), and preliminary efficacy and to establish the mtd (maximum tolerated dose), if any, and rp2d (recommended phaseii dose) of esg206 in adult subjects with b lymphoid malignancies.


Eligibility criteria:
inclusion criteria: * willing and able to provide written informed consent for the trial. * male or female and at least 18 years of age. * subjects must have a histologically confirmed (or documented), incurable b-cell hematologic malignancy that had progressed despite standard of care therapy and for which there was no alternative therapy of proven benefit or no effective standard therapy is available or tolerable. * measurable or evaluable disease. * eastern cooperative oncology group (ecog) performance status of 0 or 1. * subject must have adequate organ function. exclusion criteria: * has had prior chemotherapy, targeted therapy, immunotherapy or any other agents used as systemic treatment for cancer, within 14 days before first dosing. * had major surgery within 4 weeks before first dosing. * had undergone an autologous stem cell transplant within 100 days before first dosing. * evidence of severe or uncontrolled systemic diseases (e.g., unstable or uncompensated respiratory, hepatic, or renal disease). * known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to the investigational product or excipients. * pregnant or breastfeeding women. * unwillingness or inability to follow the procedures outlined in the protocol.
radiation with concomitant and then sequential temozolomide in malignant glioma

Conditions: Newly Diagnosed Supratentorial Malignant Glioma

Summary: to determine the safety and efficacy of gliadel 3.85% wafers plus surgery and radiation with temozolomide

a phase ii study of radiation with concomitant and then sequential temozolomide in patients with newly diagnosed supratentorial malignant glioma who have undergone surgery with gliadel wafer insertion. to determine the safety and efficacy of gliadel 3.85% wafers plus surgery and limited field radiation therapy with concomitant temozolomide followed by temozolomide alone in patients undergoing initial surgery for newly diagnosed unifocal moderate to high grade glioma.

Eligibility criteria:
inclusion criteria: * mri showing unilateral supratentorial cerebral tumor * surgical tx within 4 weeks of baseline mri * kps 60% or higher * moderate to high grade malignant glioma exclusion criteria: * prior cytoreductive surgery for moderate or high grade glioma * prior cns radiotherapy * prior chemo for this glioma * more than one focus of tumor or tumor crossing the midline per mri * life expectancy less than 12 months * sensitivity to temozolomide, nitrosoureas, or gliadel wafer

Keywords: glioma gliadel wafer
reduction of bacterial resistance with inhaled antibiotics in the intensive care unit

Conditions: Respiratory Infection; Bacterial Resistance; Respiratory Failure

Summary: the purpose of this study was : * to determine the effect of inhaled antibiotics on airway bacteria in ventilated patients * to determine the effect of inhaled antibiotics on respiratory infection

double-blind randomized placebo controlled study examining the effect of aerosolized antibiotics on respiratory infection signs and symptoms and on bacterial eradication and resistance. systemic antibiotics are administered by the responsible physician

Eligibility criteria:
inclusion criteria: * be on mechanical ventilation greater than 3 days * greater than or equal to 18 years and survival greater than 14 days * organisms on gram stain with increasing purulent secretions exclusion criteria: * pregnancy * allergy to drugs administered

Keywords: aerosolized antibiotic ventilator-associated pneumonia bacterial resistance ventilator -associated tracheobronchitis clinical pulmonary infection score
the effects of chiropractic care and children with subclinical spinal pain

Conditions: Subclinical Spinal Pain

Summary: there is growing evidence that chiropractic care positively impacts various aspects of central and autonomic nervous system function.this study aims to investigate short term and long-term effects of chiropractic care (cc) on neurological, behavioral, immunological functions and health-related quality of life in children with subclinical spinal pain.

there is growing evidence that chiropractic care positively impacts various aspects of central and autonomic nervous system function. a single chiropractic adjustment session has been shown to alter pre-frontal cortex (pfc) activity in adults, but there is a lack of robust research investigating any long-term benefits of such pfc changes in children. this study aims to investigate short term and long-term effects of chiropractic care (cc) on neurological, behavioral, immunological functions and health-related quality of life in children with subclinical spinal pain. in this parallel-group randomized controlled trial, participants aged 10-18 years with subclinical spinal pain will be randomly allocated to receive either 12 weeks of cc intervention or control intervention. primary outcomes include functional near-infrared spectroscopy, heart rate variability (hrv) and resting-state electroencephalography (eeg). the secondary outcomes include executive functions measured by cognitive testing, immune and inflammation status, and health-related quality of life. as data collected in the project is the combination of extrinsic (sociodemographic, clinical questionnaires etc.) and intrinsic physiological data (physiological measures like eeg, hrv etc.), we will utilize the advances in machine learning or artificial intelligence (ai) to help inform the development of optimal chiropractic care plans in future.

Eligibility criteria:
inclusion criteria: * aged between 10 and 18 years * have subclinical spinal pain exclusion criteria: * no evidence of spinal dysfunction is present * they are in current pain (above 3/10 on vas) * have sought previous treatment for their spinal issues * are unable to perform the assessment procedures due to contraindications or movement limitations * diagnosed immune dysfunction * utilizing a prescribed immunosuppressive medication * have uncontrolled asthma * nasal polyps * use of an intranasal steroid spray one month or less before the study * are hiv-positive * are participating in another research study at the time of data collection * have any diagnosed comorbidity or concomitant disease * have allergies to yeast or yeast-derived products * have chronic sinusitis or recent (within the last six weeks) episode of acute sinusitis.
eit assessment of overdistension in ards patients in prone position

Conditions: Acute Respiratory Distress Syndrome

Summary: mechanical ventilation in ards requires protective ventilation with low vt and peep. peep titration can improve lung recruitment in the dependent lung but with a risk of overdistension in the non-dependant lung. eit can measure the distribution of tidal ventilation and assess overdistension and collapse during a peep titration in any position (prone or not). this study aims to measure the best peep as a compromise between recruitment and overdistension during a peep trial with eit before and just after pp.


Eligibility criteria:
inclusion criteria: * patients hospitalized in the icu and who suffered moderate or severe ards (berlin criteria, pao2/fio2\<150), intubated sedated, under myorelaxant and equipped with eit * over the age of 18. exclusion criteria: * broncho-pleural leaks * pregnant or breastfeeding woman. * guardianship or curatorship * deprived of liberty * no health insurance * impossibility to correctly position the eit belt (e.g., dressings, chest drainage, etc.) * contra indications to eit (e.g., implantable cardiac defibrillator, pacemaker, instable spinal lesions)

Keywords: ventilation induced lung injury lung overdistension lung collapse electrical impedance tomography pressure volume curve prone position
a study of rapastinel as adjunctive therapy in major depressive disorder (rap-md-01)

Conditions: Depressive Disorder, Major

Summary: this study will evaluate the efficacy, safety, and tolerability of rapastinel 450 mg compared to placebo adjunctive to antidepressant therapy (adt) in patients with major depressive disorder (mdd) who have a partial response to adt.


Eligibility criteria:
inclusion criteria: * meet diagnostic and statistical manual of mental disorders, fifth edition (dsm-5) criteria for mdd * current major depressive episode of at least 8 weeks and not exceeding 18 months in duration at visit 1 * have no more than partial response (\< 50% improvement) to ongoing treatment with a protocol-allowed antidepressant * if female of childbearing potential, have a negative serum β-human chorionic gonadotropin (β-hcg) pregnancy test. exclusion criteria: * dsm-5-based diagnosis of any disorder other than mdd that was the primary focus of treatment within 6 months before visit 1 * lifetime history of meeting dsm-5 criteria for: 1. schizophrenia spectrum or other psychotic disorder 2. bipolar or related disorder 3. major neurocognitive disorder 4. neurodevelopmental disorder of greater than mild severity or of a severity that impacts the participant's ability to consent, follow study directions, or otherwise safely participate in the study 5. dissociative disorder 6. posttraumatic stess disorder 7. mdd with psychotic features * significant suicide risk, as judged by the investigator.
bilateral infant stimulation study

Conditions: Parent-Child Relations; Preterm Birth; Stress Reaction; Hospitalism in Children

Summary: this study will investigate stress that parents of children admitted to the neonatal intensive care unit (nicu) experience. investigation of a novel intervention of using bilateral alternating stimulation to reduce parental stress and anxiety and increase bonding/attachment in nicu. evaluate parental stress and feelings of bonding using surveys before and after the intervention. intervention will be done at neonate's bedside while admitted to the nicu. vital sign data will be collected as a marker of parent and neonate's stress response during the intervention.

objectives: 1. examine the effect of a bilateral alternating stimulation (bas) nicu intervention on parental anxiety and psychological distress in the nicu using biological and self-report measurements. 2. examine the effect of a bilateral alternating stimulation nicu intervention on infants' physiological stress response after parental engagement in the bas intervention with the infant. this is a pilot study of bilateral alternating stimulation (bas) examining the effectiveness as a therapeutic intervention for parental and infant stress in the nicu. it is a single arm design. participants include parents and their infant that is currently admitted to the nicu. all participants will engage in parent-neonate intervention session, following this, infants will complete a delayed comparison arm (control session) with the interventionist. infants currently admitted to nicu will be screened for eligibility, and if eligible, the families will be approached for enrollment. families that enroll will be scheduled for one study session. during study session, parents will wear a heart rate monitor, complete psychologic scales of anxiety, stress, and feelings of closeness to thier infant, parents will be trained on the intervention and then engage in the intervention with their infant. continuous vital signs will be collected for infant throughout the study session. after the intervention, parents will complete psychologic scales and satisfaction scales. infants will then be scheduled for follow-up session where an interventionist will engage infant in intervention and vital signs will be collected throughout.

Eligibility criteria:
inclusion criteria: * admitted to the nicu at the time of study * greater than 34 weeks gestational age and less than 43 weeks gestational age * within 4 weeks of admission to nicu at time of initial contact * have parent or legal guardian willing and able to participate in the study exclusion criteria: * those who are less than 3 days postop from surgical procedures * current use of psychotropic medications or medications that affect the central nervous system (cns) * cns anomaly.

Keywords: neonates heart rate variability bilateral stimulation positive touch nicu
effects of electrical nervous stimulation transcutaneous in hypertensive patients

Conditions: Hypertension; Hypertension,Essential

Summary: systemic arterial hypertension is a disease characterized by high blood pressure levels. it has a high prevalence, is a precursor of cardiovascular diseases, resulting in high costs to the health system and increased mortality. transcutaneous electrical nerve stimulation (tens) is a low-frequency pulsed electrical current widely used for analgesia. recently, it has been proposed as a non-pharmacological strategy for blood pressure control. the aim of this study is to verify the effect of low-frequency tens when applied in different anatomical sites on blood pressure, autonomic control and endothelial function in hypertensive patients.

systemic arterial hypertension is a disease characterized by high blood pressure levels. it has a high prevalence, is a precursor of cardiovascular diseases, resulting in high costs to the health system and increased mortality. transcutaneous electrical nerve stimulation (tens) is a low-frequency pulsed electrical current widely used for analgesia. recently, it has been proposed as a non-pharmacological strategy for blood pressure control. the aim of this study is to verify the effect of low-frequency tens when applied in different anatomical sites on blood pressure, autonomic control and endothelial function in hypertensive patients. for this, patients will be randomized into 4 groups: group 1 (cervical stimulation), group 2 (plus cervical stimulation ), group 3 (renal stimulation), group 4 (control). group 1 will receive tens in the cervical paravertebral region; group 2 will receive stimulation in the cervical paravertebral region, ear lobe, wrist and ankle. group 3 will have the anatomical region of the kidneys stimulated. group 4 will not receive any intervention. all the treated patients will receive 30 minutes of stimulation per session, regardless of group allocation. ten applications will be carried out over the course of a month.

Eligibility criteria:
inclusion criteria: - diagnosis of systemic arterial hypertension: systolic blood pressure (sbp) ≥ 130 mmhg and diastolic blood pressure (dbp) ≥ 80 mmhg diagnosed by ambulatory blood pressure monitoring (abpm). exclusion criteria: * congestive heart failure * patients with a cardiac pacemaker * previous heart surgery * patients with serum creatinine \>2.5 mg/dl * change in drug therapy in the two months prior to starting the study * active smoking
efficacy and antimicrobial activity of platelet rich plasma (prp) in acne vulgaris

Conditions: Platelet-Rich Plasma; Acne Vulgaris

Summary: efficacy and antimicrobial activity of platelet rich plasma (prp) in acne vulgaris : a randomized controlled trial

acne vulgaris is one of the most common chronic skin diseases worldwide. the condition usually starts in adolescence, peaks at the ages of 14 to 19 years and frequently resolves by mid-twenties. acne is characterized by seborrhea, formation of open and closed comedones, erythematous papules and pustules and in more severe cases present with nodules, deep pustules and pseudo cysts, in many cases a degree of scarring will ensue. its pathophysiology includes hyperseborrhoea, abnormal follicular keratinization and propionibacterium acnes proliferation in the pilosebaceous unit. acne is a significant clinical problem with sever social, psychological, and emotional implications. a mainly genetically determined host response pattern combined with bacterial ''triggering'' is generally accepted as being important for the apparently unbalanced inflammatory activity. acne is not an infectious disease, but three major organisms were isolated from the surface of the skin and the pilosebaceous duct of patients with acne including propionibacterium acne, staphylococcus epidermidis and malassezia furfur. platelet rich plasma is a good choice for the treatment of acne and atrophic scars reminiscent of the course of the disease. in addition, for being autologous, it reduces the possibility of side effects, such as skin dryness and rejection. it was demonstrated that prp accelerates the healing process, regulates inflammation and promotes healing by inhibiting the p. acnes bacteria, additionally restoring collagen). the prp's mechanism of action also involves the release of powerful antimicrobial peptides from the platelets' alpha granules. although there are few studies on the prp's effectiveness in acne, it emerges as a potential therapeutic option in dermatology and aesthetic medicine. due to development of resistance in microorganisms causing acne to common antibiotics and differences in species and strains of the microorganisms in different regions, this study will be undertaken to determine bacteria involve in acne vulgaris and the effect of prp on it.

Eligibility criteria:
inclusion criteria: * patients with active acne vulgaris lesions (inflammatory and non-inflammatory). * age range from 14 to 40 years. * patients with any topical and systemic treatments will undergo wash out period of one month. exclusion criteria: * patients with herpes labials, or bacterial infection; warts on the face, actinic keratosis, or skin cancer or allergy to medications. * systemic retinoids intake in the previous 6 months * history of keloidal scarring. * patients on anticoagulant therapy or aspirin or have a coagulation issue, * patients with hemoglobin less than 10g\\dl or platelet less than 105 micron\\l * pregnant women * immunocompromised patients * patients with medical diseases like diabetes mellitus, epilepsy or malignancy
one-step nucleic acid amplification for detecting lymph node metastasis of head and neck squamous cell carcinoma

Conditions: cN0 Oral Squamous Cell Carcinomas

Summary: the investigators main objective is to show that osna technique is as accurate as pathological analysis (frozen section / he staining and immunochemistry) to detect occult lymph node metastasis (micro and macrometastasis).


Eligibility criteria:
inclusion criteria: * patient \> 18 years old * head and neck squamous cell carcinoma diagnosed by biopsy * n0 classification (n0: no lymph node invasion on clinical and radiological examination). * neck dissection or sentinel lymph node biopsy required to treat the patient * ecog 1,2 or 3 * patient's consent exclusion criteria: * patient previously treated by radiotherapy or surgery for head and neck neoplasm. * contraindication or patient unwillingness to undergo surgical treatment * incapacitated adults