Kornimate/medical-research-clean huggingface dataset:
multicenter trial for patients with acute crohn's disease

Conditions: Crohn's Disease

Summary: the purpose of this study is to see if etiprednol dicloacetate is safe and effective for the treatment of acute crohn's disease.


Eligibility criteria:
* must have active confirmed crohn's disease with cdai \> 220 and \< 400. * otherwise healthy.
randomized trial assessing quinagolide vaginal ring for endometriosis-related pain

Conditions: Endometriosis-related Pain

Summary: to evaluate the efficacy of three doses of quinagolide administered as an extended-release vaginal ring compared to placebo on reduction of moderate to severe endometriosis-related pain


Eligibility criteria:
inclusion criteria: * pre-menopausal females aged ≥18 years at time of signing informed consent(s) with regular menstrual cycles. * body mass index (bmi) of 18-42 kg/m2 (both inclusive) at screening. * initial confirmation of endometriosis by laparoscopy or laparotomy within the last 10 years before the run-in visit or visualization of persistent endometrioma by repeat ultrasound. * transvaginal ultrasound documenting a uterus with no clinically significant abnormalities and presence of at least one ovary with no clinically significant abnormalities (with the exception of endometrioma) at the run-in visit. * eligible participants experienced moderate to severe endometriosis-related pain, which was defined as at the run-in visit, the participant having an nrs score of ≥5 for the worst endometriosis related pain during the past menstrual cycle and at randomization, the participant having a mean daily nrs score of ≥4 for the worst endometriosis related pain during each run-in menstrual cycle. exclusion criteria: * history of no relief of endometriosis related pain after any medical therapy or surgery. however, history of partial pain relief, discontinuation due to side effects are not exclusionary. * known bone diseases (e.g. osteoporosis, paget's disease and osteomalacia) affecting bone resorption or bone formation markers. * any significant abnormal findings of heart examinations before randomization. * history of mental illness including occurrence of acute psychosis, bipolar disorders and schizophrenia (except for well-controlled anxiety and/or depression with no changes to interventions for 6 months prior to start of run-in) * history of impulse control disorders including pathological gambling, compulsive buying, hypersexuality, and binge eating or being identified with potential impulse control disorder by the questionnaire for impulsive-compulsive disorders (a score ≥2 for any sub-questions of question 3 or a score ≥1 for any sub-questions of question 4) prior to randomization. * history of orthostatic hypotension or recurrent syncope.
postoperative analgesia with local infiltration after periacetabular osteotomy

Conditions: Periacetabular Osteotomy; Pain

Summary: pain treatment after periacetabular osteotomy is traditionally based on systemic opioids wich have side effects. the purpose of this study is to evaluate the analgetic effect of wound infiltration with local anaesthesia after periacetabular osteotomy.


Eligibility criteria:
inclusion criteria: * periacetabular osteotomy due to traditional dysplasia or retroverted acetabulum * informed consent exclusion criteria: * intolerance of local anaesthesia * habitual use of opioids

Keywords: anesthetics local infiltration periacetabular osteotomy
bilateral ultrasound guided superficial cervical plexus block after thyroid surgery

Conditions: Bilateral Ultrasound Guided Superficial Cervical Plexus Block; Thyroid Surgery; Enhanced Recovery

Summary: evaluating ultrasound guided bilateral superficial cervical plexus block as a part of enhanced recovery after thyroid surgery using quality of recovery-15 scale as a method for assessment of quality of recovery.

surgery of the thyroid gland is increasingly popular performed as ambulatory procedures in many countries. postoperative wound pain is a common complication, especially within 24 hr after thyroid surgery, which may delay discharge or even unplanned readmissions following day surgery. several strategies, including local and regional anesthesia, are now performed as core components of multimodal analgesia for postoperative pain. adequate postoperative pain relief is imperative to improve functional outcome, accelerate early ambulation and discharge from the hospital. ultrasound-guided superficial cervical plexus block was introduced by tran et al . the main advantages of ultrasound-guided superficial cervical plexus block include: provide real-time visualization of anatomical structures, reduced volumes of local anesthetics, and avoid inadvertent damage or accidental puncture of vessels. owing to its feasibility and efficacy, ultrasound-guided bilateral superficial cervical plexus block is a technique for providing adequate regional analgesia during thyroidectomy with improvement of patient recovery. quality of recovery after anesthesia is an important measure of the early postoperative health status of patients. based on extensive clinical and research experience with the 40-item quality of recovery-40, the strongest psychometrically performing items from each of the five dimensions of the quality of recovery-40 were selected to create a short-form version. the quality of recovery-15 provides a valid, extensive, and yet efficient evaluation of postoperative quality of recovery.

Eligibility criteria:
inclusion criteria: * patients aged 21 to 65 years * american society of anesthesiologists physical status i or ii. * scheduled for elective thyroid surgery. exclusion criteria: * patient refusal to participate. * patients with history of allergy to local anesthetics. * patients with history of chronic use of pain killers . * patients presented with mental dysfunction. * patients with coagulation disorders. * patients presented with skin or soft tissue infection at the proposed site of needle insertion. * patients with chronic obstructive pulmonary disease or body mass index more than 40.
safety and effectiveness of sustained release bupropion in treating individuals with schizophrenia who smoke

Conditions: Tobacco-Use Disorder; Schizophrenia; Psychotic Disorders

Summary: many individuals with schizophrenia smoke cigarettes. individuals in the schizophrenic population often find it difficult to quit smoking. the purpose of this trial is to determine the safety and effectiveness of bupropion in treating individuals with schizophrenia who smoke.

schizophrenia affects 1 % of the population. among individuals with schizophrenia, between 74 and 92 % smoke cigarettes regularly. heavy smoking represents a significant and neglected public health problem for people with schizophrenia; smoking cessation treatment is often overlooked as part of the psychiatric care for such individuals. the most effective treatment for smoking cessation described to date is sustained release (sr) bupropion. past research suggests that sr bupropion may be especially effective in individuals with depressive symptoms, including individuals with schizophrenia. the purpose of this trial is to evaluate the safety and efficacy of sr bupropion, when combined with cognitive behavioral therapy (cbt), in individuals with schizophrenia. this trial will last 12 weeks. participants will be randomly assigned to receive sr bupropion or placebo. all participants will receive weekly cbt. participants will be followed for 3 months following completion of the 12-week treatment session.

Eligibility criteria:
inclusion criteria: * meets dsm-iv criteria for schizophrenia or schizoaffective disorder * receiving a stable dose of antipsychotic medication for at least 1 month prior to study entry * smokes at least 10 cigarettes per day * wishes to stop smoking * attended last three scheduled clinic visits, prior to study entry exclusion criteria: * significant medical or neurologic illness * history of severe head injury with loss of consciousness * treated with monoamine oxidase inhibitors or carbamazepine in the 14 days prior to study entry * taking clozapine at doses greater than 500 mg/d without an anticonvulsant * currently undergoing an acute exacerbation of psychotic symptoms * current or history of bulimia or anorexia * current excessive water intake * recent history of mania * known allergy or hypersensitivity to bupropion * current substance abuse other than tobacco, nicotine replacement treatment, or smokeless tobacco * currently receiving treatment with bupropion * pregnant or breastfeeding

Keywords: bupropion zyban wellbutrin smoking cessation schizophrenia schizoaffective disorder cognitive behavioral therapy
effect of a modified 5:2 intermittent fasting diet on population with overweight or obesity in china

Conditions: Overweight or Obesity

Summary: this study aimed to investigate the effects of the modified 5:2 if dietary intervention on the chinese population with overweight or obesity based on a self-controlled clinical trial.

there are fewer studies on the influence of dietary interventions on the chinese populations with obesity, and the degree of obesity, body fat distribution, dietary pattern and structure, and metabolic status of populations with obesity are different between the chinese and european populations. the effects of a 5:2 if dietary intervention on the chinese population with overweight or obesity are unclear. therefore, this study aimed to investigate the effects of the modified 5:2 if dietary intervention on the chinese population with overweight or obesity based on a self-controlled clinical trial.

Eligibility criteria:
inclusion criteria: 1. participants aged 18 to 60 years 2. participants with a body mass index (bmi) ≥ 24 kg/m2 3. participants engaged in light physical labor and their weight was relatively stable. exclusion criteria: 1. participants taking any medication with an effect on body weight in the three months prior to enrollment; 2. participants with liver or kidney dysfunction (liver enzymes ≥ 2 times normal; blood creatinine \> the upper limit of normal); 3. participants with a history of cardiovascular disease (e.g., coronary heart disease, stroke); 4. participants with malignant tumors; 5. women during pregnancy or breastfeeding; 6. participants deemed unsuitable by the investigator to participate in this trial.
mechanically optimizing cardiac preload in heart failure patients

Conditions: Heart Failure

Summary: the purpose of the current study is to determine if partial balloon occlusion of the inferior vena cava can optimize cardiac pre-load and subsequently pulmonary pressures and cardiac output as a novel method to unload pulmonary edema and other symptoms of decompensated congestive heart failure. all products in this study are fda approved and adhere to the specifications of the intended use.


Eligibility criteria:
inclusion criteria: 1. subjects scheduled to undergo a right heart catheterization at saint thomas hospital. 2. new york heart association (nyha) ii or iii. 3. subjects must be last least 18 years of age. 4. a left ventricular ejection fraction \>= 20%. 5. pulmonary artery occlusion pressure, or pulmonary wedge pressure \>20 mmhg. exclusion criteria: 1. subjects without sinus rhythm. 2. evidence of right heart failure. 3. patients with primary pulmonary hypertension 4. pulmonary wedge pressure \<15mmhg. 5. significant lung disease, such as prior diagnosis of copd. 6. resting or dynamic outflow tract gradient 7. patients with left bundle branch block

Keywords: pulmonary edema, preload
the effect of the virtual escape room method on pediatric drug administration knowledge, self-efficacy, clinical comfort, and anxiety in nursing students: a randomized controlled study

Conditions: Pediatric Medication

Summary: children are particularly vulnerable to injuries resulting from medication errors due to the severity of the illness, the need for high-risk drugs with a narrow therapeutic range, and the frequent use of intravenous infusions. despite recent advances in pharmacological research in the pediatric population, the issue of availability of medications suitable for children has not yet been resolved. therefore, in the pediatric group, it is necessary to calculate the correct dosage of medications, prepare them with appropriate methods, and dilute them with suitable diluents. the literature indicates that dosage calculation errors are the most common medication errors in neonatal and pediatric patients. it is unclear whether nursing students are adequately prepared to provide pharmaceutical care in practice. nursing students and new nursing graduates often lack the competence to administer medications safely. therefore, training should be planned to enhance students' competencies and knowledge levels. the inclusion of newer methods in educational techniques has become essential as technology and social media increasingly engage nursing students. today's nursing students need alternative, innovative ways to be involved in the learning process. among these methods, gaming is used in nursing education to support the development of critical thinking and practical skills in students. game-based learning has the potential to engage students and enhance learning, offering numerous advantages alongside innovation and excitement. in light of these advantages, the aim of this study is to evaluate the effects of a virtual escape room application on nursing students' knowledge level, self-efficacy, clinical comfort, and anxiety in pediatric medication management.


Eligibility criteria:
inclusion criteria: * being a 3rd year nursing student, * having a computer or smart phone, * volunteering to participate in the study exclusion criteria: * students who repeated a grade, * students who suspended their nursing education, * students who cancelled their registration

Keywords: virtual escape room, nursing, paediatric drug administration, self-efficacy, anxiety, clinical comfort
remote ischemia pre-conditioning in patients undergoing partial nephrectomy

Conditions: Renal Cell Carcinoma

Summary: partial nephrectomy has become the standard treatment in patients with tumours \<7cm (t1). even though this is a nephron sparing surgery, there is still potential for acute kidney injury, due to ischemia during the surgery. remote ischemia preconditioning may prevent acute kidney injury and in turn chronic kidney disease. remote ischemia pre-conditioning involves applying a blood pressure cuff and inflating and deflating several times immediately prior to surgery.


Eligibility criteria:
inclusion criteria: * patient must be a candidate for laparoscopic partial nephrectomy * ecog performance status of 0-1 exclusion criteria: * no diagnosis of any current cutaneous, vascular or neural disease in the right upper arm. * if the patient received isoflurane for any indication during the operation

Keywords: partial nephrectomy renal cell carcinoma renal function remote ischemia preconditioning
knowledge, attitude and practice in utilization of vital pulp therapy in permanent teeth by pediatric dentists in egypt

Conditions: Vital Pulp Therapy

Summary: conducting this questionnaire will help in collecting information about the extent of knowledge, attitude, and practice of utilization of vital pulp therapy in permanent teeth among pediatric dentists in egypt. this will aid in identifying the knowledge gap, interest, attitude, and practice challenges regarding vital pulp therapy.


Eligibility criteria:
inclusion criteria: * pediatric dentists who work in egypt. * dentists who finished any postgraduate study in pediatric dentistry. * the workplace should be anywhere in egypt exclusion criteria: * dentists who did not practice for the last 5 years. * responses with incomplete information

Keywords: vital pulp therapy permanent teeth pediatric dentists
effect of free fatty acids (ffa) on androgen precursors in women

Conditions: Hyperandrogenism; Glucocorticoid Metabolism

Summary: the purpose of this study is to determine whether free fatty acids modify the androgen levels in healthy young women.

free fatty acids (ffa) are known to play an important role by inducing insulin resistance and metabolic disturbances in obesity and type 2 diabetes. in addition, ffas seems to have a stimulatory effect on adrenal androgen precursors in men. however, the effect of ffas on androgen precursors and androgens in women is yet unknown. therefore the effect of increased ffas on adrenal androgens and androgen precursors should be investigated in a randomized controlled cross-over trial.

Eligibility criteria:
inclusion criteria: * healthy men and women exclusion criteria: * diabetes mellitus or impaired glucose tolerance * clinical signs of hyperandrogenism * polycystic ovary * hormonal therapy * bmi \> 30 kg/m2 * dysmenorrhoea

Keywords: androgens fatty acids
pet-mr imaging of coronary atherothrombosis

Conditions: Heart Diseases, Ischemic

Summary: heart attacks remain a common cause of death throughout the world. the most common initiating event is the formation of a blood clot within the coronary arteries occluding blood supply to the heart. however, we know that thrombus often occurs within the coronary arteries without causing any symptoms, and may be found in patients with stable angina. we wish to investigate whether blood clots within the coronary arteries can be detected in patients who have had a heart attack and in patients with stable angina using combined positron emission tomography and magnetic resonance (pet-mr) imaging. if possible, this may provide a safe and noninvasive means of identifying patients at higher risk of heart attacks. the study will be conducted in edinburgh heart centre and a total of 40 participants will be recruited from the cardiology wards, outpatient clinics and day case unit. participants will be asked to undergo a single pet-mri scan in addition to invasive angiography as part of standard care (non-research procedure). during the invasive angiogram procedure, an additional imaging test may be performed called optical coherence tomography to provide images from within the heart blood vessels.


Eligibility criteria:
inclusion criteria: * previously diagnosed coronary artery disease undergoing elective invasive angiography or * admitted with acute coronary syndrome diagnosed by two of the following criteria 1) elevation of cardiac biomarkers (high sensitivity cardiac troponin i greater than 34 ng/l in men and 16ng/l in women) 2) symptoms of myocardial ischaemia 3) ecg changes indicative of acute ischaemia exclusion criteria: * contraindication or inability to undergo mri scanning * renal failure (estimated glomerular filtration rate less than 30ml/min * undergoing primary pci * ongoing myocardial ischaemia or dynamic ecg changes * inability to provide informed consent * known allergy to gadolinium based contrast * women who are pregnant, breastfeeding or of child-bearing potential
the cultural sensitivity education program

Conditions: Intercultural Sensitivity

Summary: the research was carried out with a randomized controlled experimental design in order to determine the effect of intercultural sensitivity training applied to nurses on intercultural sensitivity and compassion level. nurses working in a private hospital were included in the sample of the study. a total of 66 nurses, 32 of whom were in the intervention and control groups, were included in the study. "personal information form", "intercultural sensitivity scale" and "compassion scale" were used to collect data. "intercultural sensitivity training" consisting of four sessions was given to the intervention group.

within the scope of the research, an intercultural sensitivity training program for nurses was created. the training program was implemented and an evaluation was made after the implementation.

Eligibility criteria:
inclusion criteria: * being a nurse working under the nursing services directorate * volunteering to participate in research exclusion criteria: * having a disease that prevents participation in the study

Keywords: compassion intercultural sensivity nursing
optimization of ventilator setting for acute exacerbations of chronic obstructive pulmonary disease

Conditions: Acute Exacerbation of Chronic Obstructive Airways Disease

Summary: the analysis of flow and pressure curves generated by ventilators can be useful in the individuation of patient-ventilator asynchrony, notably in copd patients. to date, however, a real clinical benefit of this approach to optimize ventilator setting has not been proven. the aim of the present study was to compare: optimized ventilation, driven by the analysis of flow and pressure curves, and standard setting (same initial setting, same time at the bedside, same physician, while the ventilator screen was obscured with numerical data always available). the primary aim was the normalization of ph at two hours, whilst secondary aims were change in paco2, respiratory rate, patient's tolerance to ventilation (all parameter evaluated at baseline, 30, 120, 360 minutes and 24 hours after the beginning of ventilation). 70 patients (26 females, aged 78±9 years, paco2 74±15 mmhg, ph 7.28±0.05, mean±sd) have been enrolled, with no basal difference between the two groups.


Eligibility criteria:
inclusion criteria: * consecutive patients aged \> 40 years affected by copd exacerbation (defined as an acute change in a patient's baseline dyspnoea, cough and/or sputum beyond day-to-day variability sufficient to warrant a change in therapy), and respiratory acidosis (ph \< 7.35) that were treated by niv in addition to standard medical therapy exclusion criteria: * the needing of intubation * the lack of informed consent

Keywords: non invasive ventilation acute exacerbation of copd optimized ventilation
safety, tolerability, pharmacokinetics (pk) and pharmacodynamics (pd) assessment of lik066 in healthy subjects and in patients with type 2 diabetes mellitus (t2dm)

Conditions: Type 2 Diabetes Mellitus (T2DM)

Summary: this study will assess safety, tolerability, and effect of lik066 on blood glucose in healthy subjects and in patients with t2dm.


Eligibility criteria:
inclusion criteria: * parts i and iii: healthy male and female subjects age 18 to 55 years of age included, and in good health as determined by past medical history, physical examination, electrocardiogram, and laboratory tests at screening. * parts ii and iv: patients, age 18-65 years, must have been diagnosed with t2dm at least 8 weeks prior to screening with hba1c 6.5 to 10.0%, inclusive, at screening. * fasting plasma glucose ≤250mg/dl at screening and baseline. * if treated with metformin, patients must be on a stable dose for 12 weeks prior to randomization and maintain the dose until the end of the study. exclusion criteria; all parts: * patients with type 1 diabetes mellitus. * patients with history of acute diabetic complications within the 6 months prior to screening. * women of child-bearing potential. * patients with signs or symptoms of significant diabetic complications. * patients treated with certain blood pressure or lipid lowering medications unless patients have been on stable doses for the 12 weeks prior to dosing. * history of drug or alcohol abuse within the 12 months prior to dosing. * any surgical or medical condition, acute or unstable chronic disease which may, based on the investigator's opinion, jeopardize the patient in case of participation in the study. other protocol-defined inclusion/exclusion criteria may apply

Keywords: t2dm, blood glucose, ogtt, lik066