Kornimate/medical-research-clean huggingface dataset:
study of longidaze in the prevention & treatment of pulmonary fibrosis, interstitial lung diseases caused by covid-19

Conditions: Fibroses, Pulmonary

Summary: a study is being conducted to evaluate the efficacy and safety of longidaze for the prevention and treatment of post-inflammatory pulmonary fibrosis and interstitial lung disease following covid-19.

the aim of the study is to compare the outcomes associated with postinflammatory pulmonary fibrosis and interstitial lung disease among a cohort of adult patients after complicated pulmonary manifestations of covid-19 in two groups: in a group of patients who were prescribed longidaze® for treatment or prevention as part of routine clinical practice, and in the group of patients who underwent dynamic observation.

Eligibility criteria:
inclusion criteria: 1. patients with residual lung changes after complicated covid-19 2. residual changes were detected no later than 2 months after the discharge after disease 3. treatment of covid-19 was in accordance with the standard of the then current temporary guidelines for the treatment of covid-19 4. age of patients over 18 years old 5. negative polymerase chain reaction (pcr) test covid-19 at least 2 times in respiratory samples or based on serology results in blood samples 6. patients in the framework of routine clinical practice, in accordance with the instructions for use before inclusion in the study, were prescribed intramuscular treatment with longidaze® at a dose of 3000 iu, 1 injection every 5 days for a total course of 15 injections or dynamic observation without the use of active therapy 7. the patient did not participate in other drug clinical trials within 1 month prior to visit 1. 8. the patient or patient's caregiver agrees to participate in the trial and sign an informed consent form 9. patient understands and agrees to follow the planned procedures. 10. women with fertile potential must agree to use at least one method of contraception before completing participation in the study. exclusion criteria: 1. women during pregnancy and lactation and women planning to become pregnant during the study period 2. severe background diseases, such as severe heart failure (class iv heart function), severe liver and kidney disease, severe bronchial asthma, severe chronic obstructive pulmonary disease, bronchiectasis, bullous emphysema and previously identified interstitial lung diseases, neurological diseases, tumors. 3. long-term bed rest, regardless of its cause 4. increased individual sensitivity to the components of the studied drug 5. pathological conditions that determine the impossibility of patient participation in the study (by the decision of the investigator) 6. medical history that, according to the investigator, does not allow the patient to be included in the study 7. a burdened allergic anamnesis, which, according to the investigator, does not allow the patient to be included in the study
effect of tele-consultation in addition with psychiatric follow-up during covid-19 in women who have medical history of post-partum depression

Conditions: Post Partum Depression

Summary: women who were able to benefit from psychiatric follow-up during the quarantine by tele-consultation have a lower risk of anxious and depressive symptoms than those who did not receive follow-up.

the pandemic of covid-19 (coronavirus desease 19) led to a strict quarantine from 15 march 2020 to 11 may 2020. maternal depression is a current pathology , especially in the post-partum (more than 15%). the quarantine could lead to anxious and/or depressive symptoms and difficulties in parents-children bonding. women who have experenced post-partum period have more chance to developp subsequent depression. among women who have experienced post-partum depression, those who were able to benefit from psychiatric follow-up during the quarantine by tele-consultation have a lower risk of anxious and depressive symptoms than those who did not receive follow-up.

Eligibility criteria:
inclusion criteria: women above 18 years old who have experienced a post-partum depression between 2013 and late of 2019 who have benefit a psychiatry post-partum follow-up (hospitalizations in psychiatry post-partum unity and/or medical consultation) by bicêtre psychiatry service who have a child less than 7 years old (preschool age) speaking and reading in french and their partner (above 18 years old) in the main analyze, only women with a indication of following psychiatric follow-up by tele-consultation (with a psychiatric follow-up at the begenning of the quarantine, who have not been follow-up by psychiatrist in hospitalization or in face to face consultation) will be analyzed exclusion criteria: people with chronic psychotic disorder (diagnostic and statistical manual of mental disorders:dsm-5 criteria) people with mental handicap people who are not able to give their consent people subject to protection measure people refusing to participate in the study

Keywords: post partum depression tele-consultation covid-19
comparison of rirs versus pcnl methods, according to postoperative pain and analgesic demand in 2 to 4 cm renal stones

Conditions: Kidney Stones

Summary: purpose: to investigate the postoperative outcomes of retrograde intrarenal surgery versus percutaneous nephrolithotomy in 2 to 4 cm kidney stones.


Eligibility criteria:
inclusion criteria: * the patients who have 2 to 4 cm kidney stones * asa score within 1 to 3 exclusion criteria: * previous surgical treatment including swl * congenital abnormalities

Keywords: stone rirs pcnl pain
assessment of the mutation of pig-a gene as biomarker of genotoxic exposure in humans

Conditions: Patient With Breast Cancer

Summary: the evaluation of the impact of environment on the incidence of cancer is a major public health issue. increased knowledge in this area is necessary for the implementation of primary prevention means with appropriate preventive measures but also to the implementation of secondary prevention measures with targeted screening actions. among the environmental exposures that may lead to cancer, mutagenic environments are of major importance, and the causal link between environmental genotoxicity and cancer has been established for a long time. it is also well established that susceptibility to mutation is highly variable among individuals. this is explained by genetic polymorphisms of genes involved in metabolism and in genome stability. the identification of biomarkers of exposure to mutagenic environments is necessary for assessing the impact of an environment in humans. some studies in animals have shown that the pig-a gene may be a biomarker of exposure to a mutagenic environment. in particular, a significant increase in erythrocyte pig-a mutants has been demonstrated in rats after a genotoxic exposure to cisplatin, but it has so far not been evaluated in humans. one study of healthy volunteers shows that the frequency of pig-a mutated cells in humans can be estimated efficiently and reliably. the pig-a gene meets all the necessary criteria for a sentinel gene for tracking of spontaneous somatic mutation frequency or induced a mutagenic environment: ubiquitous expression, phenotypic change linked to a mono-allelic mutation viability of mutated cells , spectrum off inactivating mutations (deletions, substitutions, chromosomal rearrangements). finally, the detection of the disappearance of glycosylphosphatidylinositol on the plasma membrane is easily achievable by flow cytometry.


Eligibility criteria:
inclusion criteria: * major patients, * the patients achieving a breast cancer * patients who have benefited from a breast surgery * patients to have an external adjuvant radiotherapy. * patients being able to read and understand french. * patients beneficiaries of a social security scheme. * pregnant women can not participate in this study. a pregnancy test should only be prescribed when clinically indicated, regardless of the course of the study. * patients who received information and signed informed consent exclusion criteria: patients who received chemotherapy before radiation therapy. * minor patients * patients who do not speak french and / or unable to read and understand french. * patients who have had radiotherapy history * patients who have had a history of chemotherapy * patients who have not received the information and had not signed informed consent for participation
the effect of music therapy intervention on pain and anxiety in adult patients undergoing total shoulder arthroplasty

Conditions: Arthritis

Summary: the purpose of this study is to determine if music therapy interventions as adjunct to standard surgical care reduces pre- and post-operative pain and anxiety in patients undergoing total shoulder arthroplasty as compared with patients who receive standard of care without music therapy.

this is a prospective, randomized, non-blinded clinical trial. the primary objective is to measure differences in pain and anxiety scores before and after music therapy interventions as compared to patients who do not receive music therapy.

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years of age * body mass: 50-125 kg (inclusive ) * elective total or reverse total shoulder arthroplasty surgery by the study investigator * gender: male or female (non-pregnant) * american society of anesthesiologists physical classification scale 1-3 * fluent in written and spoken english * patients capable of giving informed consent exclusion criteria: * age less than 18 years of age * non-elective surgery by the study investigator * pregnancy * american society of anesthesiologists physical classification scale 4-5 * non-english speaking persons * diagnosis of cognitive disorder or musicogenic epilepsy * pre-existing hearing problems, defined as inability to independently hear speech or music at average volume * diagnosis of cognitive disorder including psychosis and dementia and/or musicogenic epilepsy * anatomical abnormalities of the shoulder such as cancerous lesions or congenital defects

Keywords: total shoulder arthroplasty total shoulder replacement adult reverse shoulder arthroplasty
pharmacokinetics of 10 mg teduglutide in subjects with renal impairment compared to healthy subjects with normal renal function

Conditions: Renal Impairment

Summary: to evaluate the effect of renal impairment on the pharmacokinetics (pk) of teduglutide following subcutaneous (sc) administration of 10 mg teduglutide. secondary objectives are to assess the safety and tolerability of 10 mg teduglutide. a further objective is the description of the pk of teduglutide following sc administration of 10 mg teduglutide in elderly (≥ 65 years) healthy subjects compared to non elderly healthy subjects.

pharmacokinetic study.

Eligibility criteria:
inclusion criteria: * subjects with moderate, severe and end stage renal failure and matched healthy controls.

Keywords: renal impairment renal impairment study
informing policy to implement pediatric family engagement in meaningful use stage 3

Conditions: Asthma

Summary: this study will enroll parents/guardians of children who receive treatment at one of the pediatric primary care practice settings in the pediatric research in office settings (pros) network or at the children's hospital of philadelphia's pediatric research consortium (perc) network. the study will use an evidence-based conceptual model to study determinants of implementation success, implementation outcomes, and health care outcomes resulting from implementing an already functional, electronic health record (ehr)-linked asthma portal, myasthma. the study will measure the portal's feasibility and determine the impact on providing asthma education and fostering patient engagement as well as the ability to collect patient-reported outcomes for children, evaluate medication use and side effects and track parents' preferences and goals.

this study uses a newly published, evidence-based conceptual model to study the determinants of implementation success, implementation outcomes, and health care outcomes resulting from implementing an asthma portal, myasthma, in the national, agency for health care research and quality(ahrq)-funded, center for pediatric practice research and learning. technically, the portal will be implemented with 2 innovative approaches that facilitate rapid cycle evaluation in multiple electronic health records (ehrs). although many patient portals are simple vehicles for transferring information about upcoming appointments, test results or laboratory findings, the asthma portal in this project extends this basic functionality to provide asthma education, collect patient-reported outcomes, evaluate medication use and side effects, and track parents' preferences and goals. because asthma is an ahrq priority condition which addresses three ahrq priority criteria (children, low income, and special health care needs), our study will use this population to focus on stage 3 meaningful use (mu3) objectives. it is the hope that by conducting this study, translational knowledge will be gained to make recommendations for practice implementation and actionable policy statements.

Eligibility criteria:
inclusion criteria for parents/guardians: 1. parent/guardian of a child who: * is between the ages of 6-12 years old * has a diagnosis of asthma on his/her problem list at the time of recruitment * has had an office visit with asthma as a diagnosis within the past 12 months 2. must be able to speak and read english exclusion criteria for parents/guardians: 1. child has not had an office visit for asthma with in the last 12 months 2. parent or guardian does not speak or read english

Keywords: asthma pediatrics health technology meaningful use stage-3 web portal
a feasibility study of a fecal incontinence management system for medical use

Conditions: Fecal Incontinence

Summary: the purpose of this feasibility study is to evaluate the performance and skin-friendliness of the barrier of the fecal incontinence management system. the investigator will complete a questionnaire for each of the tested products and the products will be evaluated as regards leakage, wear time, and skin-friendliness.

the purpose of this feasibility study is to evaluate the performance and skin-friendliness of the barrier of the fecal incontinence management system. the investigator will complete a questionnaire for each of the tested products and the products will be evaluated as regards leakage, wear time, and skin-friendliness

Eligibility criteria:
inclusion criteria: * the subject is at least 18 years of age * the subject has fecal incontinence exclusion criteria: * the subject is pregnant and/or breastfeeding * the subject has perianal fistulas and/or hemorrhoids * it's estimated that the subject's perianal skin makes it inappropriate for subject to participate in the study (i.e. in case of damaged skin, very sweaty skin or very sinuous and folded skin)
effect of manual therapy and inmediately application of plantar orthoses

Conditions: Ankle Injuries and Disorders

Summary: limitation of ankle dorsiflexion is directly related to pronated foot. for its treatment, plantar orthoses and manual therapy are used. there is a lack of evidence on their combination, as to when the cast should be taken after manipulation. our hypothesis proposes that it is more effective to cast immediately after manipulation.

the popularity of long-distance running has increased because it can be practised in many settings, the low cost and the links to prevention of health problems. in running between 19-79% of runners may suffer a running-related overuse injury each year. pronated feet have been identified as a risk factor for lower limb overuse injury, and several studies have found that ankle dorsiflexion limitation is related to pronated feet. there is a lack of evidence on their combination, as to when the cast should be taken after manipulation. our hypothesis proposes that it is more effective to cast immediately after manipulation. the main objective is to compare the effect of manipulation with motion (mwm) performed immediately prior to casting for plantar orthoses (po) with the effect of manipulation with motion performed one week prior to casting for plantar orthoses on ankle dorsiflexion (ankle df) and foot pronation in runners with hyper pronator feet secondary to a limited ankle df. this study's population will be composed by at least 16 individuals per group, both male and female, with ages among 18 and 45. they will be randomised into two groups; group a, which will undergo mwm and have the moulds taken in phenolic foam immediately after the manipulation. the other group will be group b, which will undergo the mwm, and the moulds will be taken one week after the manipulation.

Eligibility criteria:
inclusion criteria: * runners who run on asphalt. * individuals who run at least \>6 hours per week for 6 months prior to study participation. * participants with hyperpronated feet secondary to ankle rom limitation. * runners with an ankle df difference of \>1.5cm in both feet or an ankle df of less than 11.5cm according to the lunge test. exclusion criteria: * individuals who have suffered a major injury in the previous two months. * fpi less than 6. * runners wearing minimalist footwear into which po cannot be inserted. * individuals already undergoing treatment with plantar supports. * chronic widespread pain, including fibromyalgia. * systemic rheumatic pathologies. * history of recent trauma or surgery

Keywords: ankle plantar orthoses
evaluation of the benefits of ultrasound in improving the diagnosis and management of injuries the child's ankle

Conditions: Ankle Trauma

Summary: evaluate ankle's ultrasound contribution in the accuracy of ankle's diagnosis of traumatic injuries (objectivated by reference's examination : ankle's mri)


Eligibility criteria:
inclusion criteria: * age ≥ 5 years and \< 18 years * isolated's trauma from one or both ankles * first-line consultation for pediatrics emergencies at the university hospital of lille * informed and written consent of the holders of parental authority exclusion criteria: * age \< 5 years and ≥ 18 years * history of trauma of the same ankle dating from less than 3 month * history of surgery of this same ankle * constitutional or acquired bone disease * associated trauma affecting another anatomical region than the ankle or midfoot * polytrauma (presence of several traumas including at least one endangers vital functions) * associated wound requiring surgical exploration * initial management of this trauma in another center * non affiliation to a social security scheme

Keywords: ankle diagnostic ankle's ultrasound traumatic lesion
pattern of genitourinary fistula in upper egypt

Conditions: Data Collection

Summary: the pattern of genitourinary fistula in upper egypt

a genitourinary fistula is defined as an abnormal communication between the urinary (ureters, bladder, urethra) and the genital (uterus, cervix, vagina) systems. the true incidence of genitourinary fistula is unknown. uro-genital fistulas are a great challenge for women in developing countries. the new classification of genitourinary fistula divides genitourinary fistulae into four main types, depending on the distance of the distal edge of the fistula from the external urinary meatus. these four types are further subclassified by the size of the fistula, extent of associated scarring, vaginal length or special considerations: type 1: distal edge of fistula \> 3.5 cm from external urinary meatus type 2: distal edge of fistula 2.5-3.5 cm from external urinary meatus type 3: distal edge of fistula 1.5 - \< 2.5 cm from external urinary meatus

Eligibility criteria:
inclusion criteria: - any female with genitourinary fistula exclusion criteria: * no
effects of terlipressin on renal perfusion in patients with septic shock

Conditions: Septic Shock

Summary: this open-label, randomized controlled trial aimed to investigate the effect of a fixed dose of terlipressin added to usual care vs. usual care alone on renal perfusion in patients with septic shock.

terlipressin is a synthetic vasopressin analog with great affinity to the v1 receptor (vasoconstrictive effect), and could selectively contract efferent arterioles, increase glomerular filtration pressure and renal perfusion. the investigators conducted this open-label, randomized controlled trial to observe the effects of a fixed dose of terlipressin added to usual care vs. usual care alone on renal perfusion in patients with septic shock. renal perfusion was monitored by renal contrast-enhanced ultrasound. the primary outcome was peak intensity (renal perfusion parameter) at 24 hours after enrollment.

Eligibility criteria:
inclusion criteria: 1. adult septic shock patients (age≥18 years old) 2. norepinephrine dose was more than or equal to 15μg/min exclusion criteria: 1. age older than 85 years 2. serum creatinine more than 177 μmol/l 3. acute myocardial ischemia 4. acute mesenteric artery ischemia 5. pregnancy 6. expected death within 24 hours.

Keywords: septic shock terlipressin renal perfusion acute kidney injury
combined pulsed dye laser and topical ranibizumab for treatment of port wine stain birthmarks

Conditions: Port-Wine Stain

Summary: the purpose of this study is to improve port wine stain therapeutic outcome in response to laser therapy. the researcher want to determine whether the combined use of pulsed dye laser therapy and topical ranibizumab will improve port wine stain therapeutic outcome.

combined use of pulsed dye laser to induce port wine stain blood vessel injury, and ranibizumab to prevent port wine stain blood vessel angiogenesis and recanalization after laser therapy, will improve port wine stain lesion blanching. after pulsed dye laser treatment of the entire port wine stain, topical ranibizumab will be applied to two of the test sites for two weeks following pulsed dye laser therapy. the degree of port wine stain blanching which will be quantified objectively using visible reflectance spectroscopy measurements. port wine stain test site blanching responses following the combined use of pulsed dye laser and topical ranibizumab will be compared with pulsed dye laser only and with the baseline controls.

Eligibility criteria:
inclusion criteria: * port wine stain suitable for comparison testing * age \> 18 years of age exclusion criteria: * history of photodermatoses or skin cancer * use of known photosensitizing drugs * use of immunosuppressive drugs or systemic steroids * pregnancy

Keywords: port wine stain birthmarks
biomechanical analysis of scapula and humerus with different shoulder slings

Conditions: Shoulder Injuries; Surgery

Summary: participants will be measured with motion monitor system while using 6 different slings. measurement order will be randomized, and 5 minutes resting period will be given prior measurement. scapula, humerus and thorax positions will be recorded in resting position and then with slings.


Eligibility criteria:
inclusion criteria: - exclusion criteria: * having a shoulder surgery * having scapular dyskinesis, * having shoulder pain, * having any disease that could affect posture and/or shoulder (such as scoliosis)

Keywords: rehabilitation shoulder surgery postoperative