Kornimate/medical-research-clean huggingface dataset:
influence of the composition of temporary restorative material in vital teeth

Conditions: MTA; Dental Restoration, Temporary

Summary: the aim of this study is through a randomized clinical trial, double blind, splithmouth, evaluate the success rate (retation rate and dental sensibility) of temporary direct restorations in vital teeth. the composition of the temporary direct restoration (based on zinc-oxide with eugenol; and mineral trioxide aggregate). data will be collected, tabulated and submitted to statistical analysis.

the confection of temporary direct restoration is still verry commom in dental clinic routine, either by the time required or by biological requirements.the temporary restorations must have sufficient retention and solubility between the consultation intervals to avoid displacement and infiltration; besides being biocompatible to avoid sensitivity. the aim of this study is through a randomized clinical trial, double blind, splithmouth, evaluate the success rate (retention rate and dental sensibility) of temporary direct restoration on vital teeth. the composition of the temporary material (based on zinc-oxide with eugenol; and based on mineral trioxide aggregate) will be evaluated. twenty-five participants with at least two vital teeth with the need to confection of direct restoration (each participant) will be selected. the teeth will be randomly divided into 2 different groups according to the temporary material composition (based on zinc-oxide with eugenol; and based on mineral trioxide aggregate). data will be collected, tabulated and submitted to statistical analysis.

Eligibility criteria:
inclusion criteria: * healthy volunteers; both genres; presence of at least two teeth with indication of direct restoration; good oral hygiene. exclusion criteria: * dentures or orthodontics; presence of periodontal disease and,or parafunctional habits; systemic disease and, or severe psychological; constant use of analgesic and, or anti-inflammatory or allergic response to dental products.
the effect of a low glycemic index diet on blood sugar control in pregnant women at risk for gestational diabetes

Conditions: Diabetes, Gestational

Summary: gestational diabetes mellitus (gdm) is a condition in which high blood sugar levels occur during pregnancy. gdm increases the risk of medical complications during pregnancy which may harm the mother and her baby. since treating gdm to reduce blood sugar reduces the risk of harm, all pregnant women are screened for gdm using a glucose challenge test (gct). we think that a diet containing low glycemic index foods could help keep blood sugar levels normal during pregnancy and therefore prevent gdm. thus, the purpose of this study is to see if a diet containing low glycemic index foods will reduced blood sugar after the gct and reduce the prevalence of gdm in women at high risk for the development of gdm.


Eligibility criteria:
inclusion criteria: * attending mt. sinai maternal fetal medicine unit * any one of: body mass index \>=25 kg/m\^2 * or age \>=35 years * or high risk ethnicity (asian, south asian, hispanic, african, aboriginal) exclusion criteria: * have pre-existing diabetes (type 1 or type 2) before becoming pregnant * acute or chronic illness which may affect carbohydrate metabolism * language/literacy barriers which cannot be overcome via available resources * \>16 weeks gestation

Keywords: randomized clinical trial gestational diabetes carbohydrates glycemic index
cerebral oxygen saturation measurement during cardioversion because of atrial fibrillation

Conditions: Electrical Cardioversion of Atrial Fibrillation; Pharmacological Cardioversion of Atrial Fibrillation

Summary: near infrared spectroscopy (nirs) is a technique that measures regional cerebral oxygenation in a non-invasive manner. through the use of near infrared light, the difference between oxygenated and deoxygenated hemoglobin can be measured. by applying the lambert-beer law, a numeric result can be calculated. since atrial fibrillation (af) has been linked with an increased risk for the development of neurocognitive deficits, a longer period of af might be associated with a higher risk for neurocognitive deficits. it is hypothesized that there is an increase in the regional cerebral oxygen saturation (rso2) of patients with paroxysmal or persistent af after successful cardioversion.

written informed consent by the patient is asked before cardioversion and participation in the study. patient anamnesis is assessed by standardized questionnaire. patients perform several standardised neurocognitive tests to obtain a general view on the neurocognitive status (auditory verbal learning test, mini-mental state examination, trail making a and b, digit-symbol coding and rand 36 health survey). cerebral oxygenation is observed during cardioversion by means of the sensmart model x-100 (nonin). additional parameters (pulse oximetry, cardiac output, arterial blood pressure, 6-lead electrocardiography (ecg), left ventricular ejection fraction) are recorded. all measurements are performed non-invasively. patients receive standard treatment following the clinical guidelines.

Eligibility criteria:
inclusion criteria: * older than 18 years and able to give informed consent * diagnosis of paroxysmal or persistent atrial fibrillation * scheduled for electrical cardioversion or atrial fibrillation development in the first days after cardiac surgery followed by pharmacological treatment with amiodarone * dutch speaking exclusion criteria: * younger than 18 years or not able to give informed consent * diagnosis of permanent atrial fibrillation * atrial fibrillation with thrombus in left atrial appendage * chronic obstructive pulmonary disease gold class 3 or 4 * airway manipulation during cardioversion * pregnant women * medical history of cerebrovascular accident or brain injury * medical history of cardiopulmonary resuscitation

Keywords: cardioversion atrial fibrillation
effects of acute long-acting bronchodilation on oxygenation and peripheral ventilation in copd

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: the goal of this clinical trial was to compare the action of long-acting ß2-agonists (laba-olodaterol) and muscarinic antagonists (lama-tiotropium) on tissue oxygenation in copd considering their impact on proximal and peripheral ventilation and, eventually, on lung capillary volume. the hypothesis was that laba would have a more peripheral effect than lama (due to the opposite gradient of their receptors) and better peripheral ventilation would result in a greater oxygenation. before and after laba (visit 1) and lama (visit 2) inhalation, copd participants were asked to perform single-breath washout and forced oscillation tests, double diffusion technique and spirometry, while transcutaneous oxygenation was continuously recorded.

slopes of he (she) and sf6 (ssf6) from single-breath washout test (sbwo) (assessing ventilation heterogeneities at the level of pre- and intra-acinar bronchioles, respectively) (quadruple model, lr6000 logan-sinclair, rochester, uk), respiratory system resistance (r5, r5-r19) and reactance (x5, ax, fres) from forced oscillation test (fot) (resmon pro, restech, italy), lung capillary volume (vc) from double diffusion of no and co (dlno/dlco) (hyp'air compact, medisoft, dinant, belgium), and fev1 from spirometry (zan®, oberthulba, germany) were evaluated before and after labd administered via a spacer device: during the first visit, before, 30 minutes and 2 hours after inhalation of 4 puffs of 2,5 µg of olodaterol (laba); during the second visit, before, 40 minutes and 2 hours after the administration of 4 puffs of 2,5 µg of tiotropium (lama). transcutaneous oximetry (perimed232©, järfälla, sweden) was monitored continuously during the 2 hours of each visit.

Eligibility criteria:
inclusion criteria: * copd diagnosis according to international criteria exclusion criteria: * inability to perform the tests or to maintain the washout period * an exacerbation within the previous 6 weeks * a diagnosis of asthma or another chronic respiratory disease that could influence the results of the study

Keywords: long-acting ß2-agonist long-acting muscarinic antagonist gas exchange oxygen small airways lung capillary volume
thunder: acute ischemic stroke study with the penumbra system® including thunderbolt™ aspiration tubing

Conditions: Acute Ischemic Stroke; Large Vessel Occlusion

Summary: the objective of this study is to demonstrate the safety and efficacy of the penumbra system including thunderbolt aspiration tubing (thunderbolt) in a population presenting with acute ischemic stroke (ais) secondary to intracranial large vessel occlusion (lvo) who are eligible for mechanical thrombectomy.


Eligibility criteria:
inclusion criteria: 1. patient age 18 - 80 years 2. treatment within 8 hours of symptom onset 3. pre-stroke mrs 0-2 4. patient experiencing acute ischemic stroke secondary to intracranial large vessel occlusion in the internal carotid, middle cerebral (m1 or m2), basilar, or vertebral artery 5. if patient is eligible for thrombolytic therapy, it was administered as soon as possible, and no later than 3 hours from stroke symptom onset 6. planned frontline treatment with penumbra system including thunderbolt modulated aspiration 7. informed consent obtained per institution review board/ethics committee requirements exclusion criteria: 1. stenosis, excessive tortuosity, or any occlusion in a proximal vessel requiring treatment or preventing access to the thrombus 2. alberta stroke program early ct score (aspects) ≤6 or core infarct volume \>50 ml on mri or ct-based imaging (for anterior circulation strokes) 3. pregnant patient 4. life expectancy \< 90 days due to comorbidities 5. current participation in an interventional drug or device study that may confound the results of this study. studies requiring extended follow-up for products that were investigational but have since become commercially available are not considered investigational studies 6. other medical, behavioral, or psychological conditions that in the opinion of the investigator could limit the patient's ability to participate in the study, including compliance with follow-up requirements, or that could impact the scientific integrity of the study

Keywords: acute ischemic stroke ais large vessel occlusion lvo mechanical thrombectomy penumbra system thunderbolt aspiration tubing a direct aspiration first pass technique adapt
effect of neuromuscular electrical stimulation combined with blood flow restriction on muscular and cardiovascular function

Conditions: Muscle Weakness; Muscle Atrophy

Summary: neuromuscular electrical stimulation (nmes) has recently been combined with blood flow restriction (bfr) in controlled trials and has shown increased muscular strength and size compared with nmes and bfr on their own. however, none have used bfr pressures previously recommended. the first study of my ph.d. found 40% and 80% bfr pressures to induce acute fatigue and muscle swelling. however, 80% caused higher ratings of pain and perceived exertion. the present study will determine whether nmes combined with either 40% or 80% bfr causes greater structural muscular adaptations and is perceptually easier after 6 weeks of training.

laboratory testing will take place on 28 separate occasions, 2 familiarisation, 8 testing and 18 intervention sessions. the first session (fam 1) will serve as a familiarisation trial to the nmes protocol, bfr stimulus and strength testing. it will be conducted 10-14 days prior to the intervention period. the second session (fam 2) will serve as a second familiarisation trial to the nmes protocol, bfr stimulus and strength testing. this session will take place 7 days prior to the beginning of the intervention period and will serve as a standardised control period prior to the main testing. the third session (pre) will take place 1 day prior the start of the intervention period and all future sessions will consist of strength, muscle and cardiovascular function outcome measures. the fourth session (mid) will take place the morning following 3 weeks of training. the fifth session (post1) will take place 48 hours following 6 weeks of training. there will also be post testing sessions after three days (post2), one week (post3) and two weeks post intervention (post4) to assess detraining. participants will be provided with protein supplementation after every training session. all strength, muscle and hemodynamic measurements will be conducted at st marys university by paul head. supplements should be avoided for 72 hours prior to experimental measures and throughout the intervention period. all repeated measures will be performed at a similar time of day (± 1 h).

Eligibility criteria:
inclusion criteria: * healthy adults aged between 18 and 45 years old exclusion criteria: * history of lower extremity surgery, traumatic injuries to the ankle, knee, hip, pelvis and lower back * current musculoskeletal condition * high blood pressure * cardiovascular pathology
treatment of acne scarring with a novel procedure combination

Conditions: Acne Scarring

Summary: the primary objective of this study is to look at the efficacy of subdermal manipulation and filler injection in the improvement of acne scar appearance.

the primary objective of this study is to determine whether the use of subcision in conjunction with calcium hydroxylapatite injections will improve the appearance of rolling acne scars better than subcision alone.

Eligibility criteria:
inclusion criteria: * age 18 and over * have two acne scar areas * the subjects are in good health * the subject has the willingness and the ability to understand and provide informed consent for the use of their tissue and communicate with the investigator. exclusion criteria: * under 18 years of age * pregnancy or lactation * subjects who are unable to understand the protocol or to give informed consent * subjects with mental illness
effect of piezoelectric surgery onpostoperative complications in third molar surgery

Conditions: Oral Complication

Summary: the purpose of this study is to compare the effects of piezoelectric surgery on postoperative edema, trismus and other postoperative complications (wound healing, bleeding, infection, alveolitis, paresthesia) with conventional bur method applied in surgical extraction of impacted mandibular third molars. the main question it aims to answer is: is piezoelectric surgery effective on reducing the edema, trismus and other postoperative complications (wound healing, bleeding, infection, alveolitis, paresthesia) in impacted third molar surgery? postoperative edema measurements are determined at 24 hours, 48 hours, and 7 days using the flexible ruler method. trismus is determined by measuring the interincisal distance. statistical analyses are performed to compare the two surgical methods.


Eligibility criteria:
inclusion criteria: * patients with mesioangular, distoangular, vertical or horizontal, fully impacted and fully bone retained impacted lower wisdom teeth * patients without any systemic disease * patients who have been informed about the duration, purpose and requirements of the study and who have signed the informed consent form voluntarily. exclusion criteria: * patients with any systemic contraindication, infection in the area of the tooth to be extracted, anamnesis of sensitivity to paracetamol derivatives or aspirin, pregnant or breastfeeding patients, and patients using antibiotics or anti-inflammatory drugs in the last 3 weeks * in addition, smokers or alcohol addicts were not included in the study.
comparison of ocular changes by surgical menopause using optical coherence tomography (oct)

Conditions: Corneal Deformity; Macular Degeneration Advanced; Surgical Menopause

Summary: the aim of this study is to investigate the early changes in macular thickness, corneal thickness and intraocular pressure in young women undergoing surgical menopause. methods: eye findings of 30 surgical menopausal (postoperative 3-6 months) and 48 natural menopause and 22 healty women (control) were evaluated using oct. women with no known eye disease, no chronic disease (diabetes mellitus, cardiac disease any autoimmune disease) and no migraine in addition to non smokers were included in the study. women using any hormone and obese women ( bmi \>25 kg/m2) were excluded. macular and corneal thickness and intraocular pressure (iop) were measured in both eyes of the women

this prospective case control study was conducted in a tertiary gynecology and obstetrics clinic and eye clinic between 2020 and 2021 with ethics committee approval number 2020 250 ). informed consent form was obtained from all participants. all participants were outpatients who applied to obstetrics clinic in batman training and research hospital. the study started with 105 patient. based on the study exclusion criteria, 7 patients were excluded from the study. every patient in the surgical menopause group underwent a hysterectomy and bilateral salpingo-oophorectomy for benign uterine reasons. the patients included in the study were menstruating women with preoperative natural ovarian appearance and benign non ovarian indications, who had undergone hysterectomy and bilateral salpingo-oophorectomy and had no preoperative menopause complaints. patients younger than 52 years of age who have undergone oophorectomy are patients whose ovaries have been removed either because of patient anxiety due to a family history of cancer or because of adhesions.

Eligibility criteria:
inclusion criteria: * the patients included in the study were menstruating women with preoperative natural ovarian appearance and benign non ovarian indications, who had undergone hysterectomy and bilateral salpingo-oopherectomy, and had no preoperative menopause complaints. patients younger than 52 years of age who have undergone oophorectomy are patients whose ovaries have been removed either because of patient anxiety due to a family history of cancer or because of adhesions. * having a healthy child * have consented to participate in the study exclusion criteria: * chronic disease (such as diabetes, heart disease) * history of continuous drug use * unwillingness to participate in the study being between the ages of 18-30
clinical study of ta-650 in pediatric patients with ulcerative colitis

Conditions: Pediatric Ulcerative Colitis

Summary: the purpose of this study is to evaluate the the efficacy of ta-650 using clinical activity index (cai) score and other evaluation indicators in pediatric patients with moderate to severe ulcerative colitis after ta-650 administration of at a dose of 5 mg/kg at weeks 0, 2, and 6, and then every 8 weeks at weeks 14 and 22. the safety and pharmacokinetics are also evaluated.


Eligibility criteria:
inclusion criteria: * patients who have been diagnosed as ulcerative colitis at least 3 months prior to screening. * have active ulcerative colitis despite adequate conventional therapy. exclusion criteria: * patients who have severe pancolitis. * patients who have undergone surgery for ulcerative colitis within 8 weeks before enrollment or who were judged to require surgery for ulcerative colitis at enrollment. * patients who have a history of treatment with infliximab or other biologic products (anti-tnfα agents, anti-il-6 agents, etc.).

Keywords: infliximab remicade ta-650
safety and immunogenicity of typhax, a typhoid vaccine

Conditions: Typhoid Fever

Summary: this was a randomized, double-blind, ascending dose study conducted at a single clinical research center.

healthy adult subjects aged 18 to 55 years were assigned to 3 ascending dose cohorts of typhax (0.5, 2.5 or 10 mcg vi antigen). groups of 15 subjects in each dose cohort were randomized to receive typhax, typhim vi (25 mcg vi antigen) or placebo (saline) in a ratio of 3:1:1, respectively. typhax and placebo (saline) was administered as two dose regimen (days 0 and 28), and typhim vi was given as a single dose (day 0) with matching placebo on day 28. all doses were administered by a unblinded third-party as 0.5 ml by intramuscular (im) injection. safety and reactogenicity endpoints was assessed at 14 and 28 days after the first typhax vaccination and 14 days after the second vaccination. immunogenicity was assessed using an enzyme-linked immunosorbent assay (elisa) to measure anti-vi antibody serum titers on days 0, 14, 28, 42 and 180. a positive immune response (seroconversion) by elisa is defined as at least a 4-fold increase over baseline in the vi-specific elisa.

Eligibility criteria:
inclusion criteria: * healthy adult men or women who are not pregnant or planning to become pregnant during study duration aged 18 to 55 years. * clinical laboratory parameters within normal laboratory limits or not found to be clinically significant by the pi exclusion criteria: * relevant history of physical or psychiatric illness or medical disorder that required treatment. * known or suspected hypersensitivity to investigational product * immunocompromised subjects * previous typhoid vaccination or elevated anti-vi antibodies at screening * known history of typhoid infection in the previous 6 months * positive hiv, hbsag, or hcv screen * any other condition or abnormality that, in the opinion of the investigator, may compromise the safety of the patients
evaluation of the effect of the omt exercises education for pain in participants with cervical pain

Conditions: Neck Pain; Pain, Neck

Summary: the purpose of this randomized pragmatic clinical trial is to assess the effectiveness of the association of the osteopathic manipulative treatment in individuals with chronic non-specific neck pain who receive a exercice program and pain neurocience education.

the purpose of this study is to determine whether osteopathic manipulative treatment associated exercises and pain neurocience education improves pain and function in individuals with chronic non-specific neck pain design: a randomized single blind controlled pragmatic trial will be conducted trial. patients (n=40) with non-specific neck pain will be randomized to receive 1) osteopathic manipulative treatment and exercise and and pain neurocience education (n=20) or 2) exercise alone and pain neurocience education (n=20). participants will receive 8 treatments during 4 weeks. clinical outcomes will be obtained at 1 week, four weeks and 24 weeks after end of treatment. methods: the primary outcome will be pain measured by 11-point numerical pain rating scale. the secondary outcome will be disability measured by the neck disability index, range of motion measured by cervical range of motion device, pressure pain threshold measured by electronic algometer, global perceived effect, pain self-efficacy questionnaire and pain catastrophizing scale

Eligibility criteria:
inclusion criteria: * symptoms of chronic neck pain does not specify that persists for more than 3 months * pain at least 3 points on 0-10 numeric pain rating and at least 14% disability on neck disability index exclusion criteria: * individuals who report inflammatory previous surgery, spondylolisthesis, spinal stenosis, herniated disc, radiculopathy, fracture and musculoskeletal degenerative diseases. , cancer, neurological diseases, pregnancy. they will be excluded participants who received some form of manipulative treatment in the last three months.

Keywords: neck pain