Kornimate/medical-research-clean huggingface dataset:
concomitant high-resolution recording of haemodynamic and electrical activities of children with typical or atypical absence seizures

Conditions: Epilepsy

Summary: this study, conducted in children with typical or atypical "absence" epilepsy, will consist of noninvasive recording of the metabolic activity of the brain concomitantly with electroencephalographic recording during seizures without the need for any additional examination. this examination will be performed by combining near-infrared spectroscopy (nirs) optical imaging and electroencephalography (eeg) in a simultaneous high-resolution (hr) recording. surface electroencephalography (eeg) is a valuable tool to assess neuronal dysfunction from a functional point of view and is used in the routine follow-up of epileptic children. optical imaging is a recent and promising medical imaging technique, which uses near-infrared light. this rapid, noninvasive and harmless quantitative technique can be easily used at the child's bedside or in the ward and provides metabolic information on brain functioning.


Eligibility criteria:
inclusion criteria: * children aged 3 to 14 years * featuring absence epilepsy with typical or atypical seizures characterized by the presence of spontaneous spike-wave flashes with standard eeg exclusion criteria: * all children with severe congenital malformation * any refusal of a parent or child * any child with a serious deterioration in the general condition and vital functions * any child with dermatitis of the face or scalp * children under 3 years old or over 14 years

Keywords: spectroscopy, near-infrared electroencephalography children
cystadrops in pediatric cystinosis patients from six months to less than two years old (scob2)

Conditions: Cystinosis

Summary: cystadrops® is currently indicated in adults and children from 2 years of age diagnosed with cystinosis with corneal crystal accumulation observed. however administration of cystadrops® in patients below 2 years old could be of value for these patients and prevent the crystal deposit. it is the reason why as part of the cystadrops® pediatric investigational plan (pip), recordati rare diseases committed to conduct a clinical study to assess cystadrops® safety and efficacy in the pediatric population from 6 months to less than 2 years old.


Eligibility criteria:
inclusion criteria: 1. patient aged from 6 months to less than 2 years old 2. cystinosis diagnosed patients confirmed by the physician and with presence of corneal cystine crystal deposits assessed during ophthalmic examination 3. evidence of a signed and dated informed consent document indicating that parents/ legally acceptable representatives had been informed of all pertinent aspects of the study (if required by regulation) 4. parents/ legally acceptable representatives who are willing to comply with regular visits and ophthalmic exams exclusion criteria: 1. contraindications to any of the cystadrops® components 2. participation in another ophthalmic investigational study or intent to participate during the course of the study 3. any medical condition that would, in the opinion of the investigator, interfere with the evaluation of the study objectives
examining the impact of exercise training on vascular dysfunction in individuals with mental health disorders - study 1

Conditions: Peripheral Vascular Diseases

Summary: the purpose of this research study is to examine the role oxidants, substances produced in the blood that can damage blood vessel function, may play in blood vessel function in healthy individuals as well as individuals with mental health disorders (posttraumatic stress disorder (ptsd) and/or generalized anxiety disorder (gad)).

study #1 is made up of three sessions done on three separate days and the entire study can be completed in as little as two weeks. all testing sessions will take place at the exercise physiology research laboratory. volunteers will be asked to participate in one initial testing session (visit 1) lasting \< 1 hour that will help make them more familiar with the study equipment and procedures, determine body measures (height, weight, body fat), determine the maximum strength of their forearm and calf, and require one blood draw. the following two testing sessions (visits 2 and 3) with each session lasting between 2-3 hours that will involve multiple tests designed to determine the health of their blood vessels. for visit #2 they will be randomly given either antioxidant pills or placebo pills to determine the effect of oxidants on blood vessel health. for visit #3, they will be given whatever set of pills (antioxidant or placebo) that they did not receive during visit #2.

Eligibility criteria:
inclusion criteria: * apparently healthy and free of overt cardiovascular, pulmonary, or metabolic disease * for ptsd group, a score of ≥ 33 on pcl-5 checklist * for gad group, a score of ≥ 10 on the gad-7 self-report scale and \< 33 on the pcl-5 checklist * for healthy control group, a score of ≤ 10 on the gad-7 self-report scale and \< 33 on the pcl-5 checklist exclusion criteria: * taking medications that could influence cardiovascular function * current smokers who have recently quit smoking * illicit drug use or excessive alcohol consumption * pregnant women * significant calorie restriction or vitamin/mineral deficiencies * limited english proficiency

Keywords: cardiovascular disease vascular function ptsd gad oxidant
a multicenter study of artificial intelligence model for fetal congenital heart disease

Conditions: Congenital Heart Disease (CHD); Artificial Intelligence (AI)

Summary: this study addresses congenital heart disease in fetuses, a specific birth defect, by collaborating with multicenter medical institutions across china. it prospectively collects echocardiographic screening, diagnostic images, and structured parameter data from both normal and abnormal fetuses. cases are followed up, and artificial intelligence (ai) models are developed to extract fetal heart echocardiographic image features and analyze the data. this process allows for the analysis of the ai models' accuracy, sensitivity, and specificity, and verifies the application value of ai models in fetal heart echocardiographic screening and diagnosis.


Eligibility criteria:
inclusion criteria: * single or multiple pregnancy; * gestational age 16-40 weeks; * fetal echocardiographic images are clear and complete; * clinical data are complete and detailed; * sign informed consent and be able to cooperate with follow-up exclusion criteria: * fetal echocardiographic images are incomplete or of poor quality that cannot be used for research; * refusal or loss of follow-up
interim pet/ct guided cycle numbers of r-chop in dlbcl

Conditions: Diffuse Large B-cell Lymphoma

Summary: the aim of this study is to optimize the number of cycles of r-chop in patients with diffuse large b-cell lymphoma based on the interim results of pet/ct.

r-chop is the standard regimen for patients with diffuse large b-cell lymphoma (dlbcl). however, the standard number of cycles is uncertain. recently, interim pet/ct was found to predict prognosis in dlbcl. the hypothesis of this study is to optimize the number of cycles based on the interim results of pet/ct in order to avoid treatment exposure.

Eligibility criteria:
inclusion criteria: * previously untreated diffuse large b-cell lymphoma * age range 18-80 years old * eastern cooperative oncology group performance status 0-2 * life expectancy of more than 3 months * adequate organ function exclusion criteria: * primary or secondary central nervous system involvement * previous serious cardiac disease * history of other malignancies except cured basal cell carcinoma of skin and carcinoma in-situ of uterine cervix * pregnant or lactating women * serious uncontrolled diseases and intercurrent infection

Keywords: dlbcl r-chop pet/ct
prehospital and emergency feasibility of macocha score assessment to predict difficult tracheal intubation

Conditions: Intubation, Intratracheal; Emergency Medicine

Summary: a seven-item simplified score (the macocha score) has been validated to predict difficult tracheal intubation in intensive care unit patients. in the prehospital or in the emergency department settings, no such validated predictive score is available yet. the aim of the present study is to assess the feasibility the quick calculation of the macocha score before emergent intubation, in the prehospital and emergency department contexts.

all patients who will have to undergo emergent tracheal intubation for any reason in the prehospital context or at the emergency department at a single 1100-bed regional and teaching hospital in france, will be included in this observational, prospective study, provided that neither the patient him/herself, if capable, or next-of-kin if present have declined participation. items of the macocha score will be recorded before intubation by investigators, who are all certified emergency physicians skilled with urgent tracheal intubation. for any intubation procedure, either in the out-of-hospital context or in the emergency department, one of these emergency physicians is always present. the feasibility the quick macocha score calculation before urgent intubation will be assessed by the number and percentages of patients for whom all the seven items of the score have been collected.

Eligibility criteria:
inclusion criteria: * patient ≥ 18 yrs * patient who have to undergo rapid sequence tracheal intubation as judged by the emergency physician exclusion criteria: * pregnancy * cardiac arrest of any cause as the indication for intubation * patient or next-of-kin declining participation

Keywords: predictive score difficult intubation
mortality in non-cystic fibrosis bronchiectasis

Conditions: Non-cystic Fibrosis Bronchiectasis

Summary: in this study we analyzed the overall survival for all newly diagnosed patients with non-cystic fibrosis bronchiectasis from june 2006 onwards. the investigators wanted to confirm the known risk factors such as age, gender, smoking history and pseudomonas aeruginosa and evaluate the impact on survival of etiology, number of different bacteriological species in retrospective and prospective sputa, azithromycin use and presence/development of pulmonary hypertension.


Eligibility criteria:
inclusion criteria: * patients with clinically significant and radiologically proven bronchiectasis * chest ct scan confirming the presence of bronchiectatic lesions and had symptoms of chronic productive cough * bronchiectasis was deemed to be present if there was one or more of the following criteria: a bronchoarterial ratio greater than 1, lack of tapering of the bronchi and visualization of bronchi within 1 cm of costal or paravertebral pleura or abutting the mediastinal pleura exclusion criteria: * diagnosis of cystic fibrosis * underlying tumoral problem causing the bronchiectatic lesions (postradiotherapy, secondary immunodeficiency due to chemotherapy or postinfectious due to tumoral obstruction) * patients with asymptomatic traction bronchiectasis caused by interstitial lung disease
online hiv prevention vignette evaluation

Conditions: HIV Infections

Summary: this is an evaluation of the effect that an online live action, dramatic vignette about four gay men, two hiv positive and two hiv negative, struggling with the responsibility for safer sex has on the sexual behavior and hiv testing intentions of the gay/bisexual men who watch the vignette and participate in the evaluation study. the primary hypothesis is that men will be more likely to: 1)express the intent to have an hiv test and 2) to express the intent to inform their sex partners of their hiv status after watching the vignette. the secondary hypothesis is that men will be more likely to follow through on these intentions in the three months following the intervention than they were in the three months before viewing the vignette. this is a one group pre-posttest intervention in which each man serves as his own control.

* men over 18 years of age will be recruited for the study through a banner posted on the exit page of manhunt.net an internet gay hook-up site. those clicking on the banner will go to the evaluation website (www.hivbigdeal.org) * asked to read the consent and click agreement. * asked to complete a relatively brief questionnaire about their sexual behavior, hiv testing and hiv disclosure in the preceding three months * watch the 8 minute dramatic vignette * complete a brief questionnaire that elicits their response to the video and their hiv testing and disclosure intentions. * if they agree to provide the study with their e-mail address, participants will be re-contacted in three months and asked to complete a second behavioral survey online that asks about sexual behavior, hiv testing and hiv disclosure in the three months since watching the vignette.behavior before and after watching the vignette will be compared. * the entire study will be conducted online.

Eligibility criteria:
inclusion criteria: * english-speaking * gay/bisexual men * age \> 18 exclusion criteria: * women * men under 18 * men who do not have sex with other men

Keywords: hiv testing hiv disclosure hiv seronegativity
pharmaceutical care of ambulatory elderly diabetes patients

Conditions: Diabetes Mellitus

Summary: this trial will try to perform pharmaceutical care on ambulatory elderly diabetes patients. to provide appropriate diabetes education administration, identify and resolve drug-related problems, assess the appropriateness of their medications, establish the mechanism of medication consultations. each patient will be assessed by the mmse(mini-mental state examination) and gds(geriatric depression scale). the effectiveness of pharmacist's intervention will be assessed by lab data and some questionnaires.


Eligibility criteria:
inclusion criteria: * age 65 years or older * a1c greater than or equal to 9.0 exclusion criteria: * not expected to live for the duration of the study * unwillingness to participate and attend pharmacist visits * unwillingness to participate the questionnaires(mmse, gds)

Keywords: pharmaceutical care diabetes mellitus
medication reconciliation in hospitalized ckd patients : a quasi-experimental study

Conditions: Chronic Kidney Disease(CKD)

Summary: this study aimed to evaluate the impact of combining medication reconciliation with medication review on reducing medication discrepancies at discharge and all-cause readmissions among ckd patients, in comparison to a retrospective control group that received usual care, which may or may not have included medication reconciliation.


Eligibility criteria:
inclusion criteria: adult (18 years or older) admitted patients with ckd (stages 2-5 ), who were using at least three chronic medicines at home, and were hospitalized for at least 48 hours. exclusion criteria: patients with kidney transplantation . patients who have difficulties in responding to interviews and did not have family member or caregiver on behave, and those who refused to provide a written informed consent.
comparison of different physical therapy modalities in lateral epicondylitis

Conditions: Lateral Epicondylitis

Summary: comparison of the effects of kinesiotaping and high intensity laser therapy in patients with lateral epicondylitis: a randomized controlled study

in this study, it was aimed to compare the effects of exercise therapy, kinesiology taping and high-intensity laser therapy on pain, muscle strength and functional status in patients with le. patients who applied to the outpatient clinic of the sadi konuk training and research hospital physical medicine and rehabilitation clinic due to elbow pain and were diagnosed with unilateral le will be included. the study was planned as randomized, prospective and controlled. patients will be randomized using a random (randomized) numbers table and distributed equally to the groups. only exercise will be applied to the first group, high-intensity laser therapy and exercise to the second group, and kinesiology taping and exercise treatments to the third group. sixty people will be included in the study. patients will be evaluated before treatment, immediately after treatment, and at 4 weeks post-treatment. in the evaluation of the patients, the severity of pain during rest and activity measured with the visual analogue scale (vas), quick disability of the arm, shoulder and hand (quickdash), patient based lateral epicondylitis evaluation test - patient rated tennis elbow evaluation (prtee), jamar' hand grip strength will be evaluated with the hand dynamometer.

Eligibility criteria:
inclusion criteria: - volunteer patients diagnosed with unilateral lateral epicondylitis exclusion criteria: * those who have previously received treatment for lateral epicondylitis * current extremity fracture or surgical history * presence of congenital deformity in the upper extremity * cervical radiculopathy, myelopathy, plexopathy, entrapment neuropathies * presence of neurological disease such as stroke, parkinson's, multiple sclerosis, epilepsy and muscle disease * presence of skin lesion, infection and open wound on the affected extremity * presence of metal implant in the affected extremity * rheumatological disease * pregnancy * pacemaker presence * malignancy * cognitive dysfunction * presence of psychiatric illness

Keywords: lateral epicondylitis kinesiotaping high intensity laser
opioid agonist and antagonist effects on opioid dependence

Conditions: Opioid-Related Disorders

Summary: the purpose of this study is to examine the acute agonist and antagonist effects of a full opioid agonist medication, an opioid antagonist medication, and a partial opioid agonist medication in individuals who have different levels of physical opioid dependence.

the pharmacological effects of opioids in opioid dependent individuals can vary as a function of the characteristics of the opioid being studied (e.g., whether it is an agonist, partial agonist, or antagonist; the dose administered; and the route of administration). another important set of factors influencing the effects produced by opioids is the characteristics of the organism to which the opioid is being administered. one such characteristic is the level of physical dependence in individuals. participants in this study will be maintained on different dose levels of an opioid agonist (methadone). the participant will be challenged with a prototypic opioid agonist, antagonist, and a mixed agonist-antagonist with partial agonist features in order to determine the effects that each has on the human body.

Eligibility criteria:
inclusion criteria: * active opioid dependence * qualifies for opioid agonist treatment (e.g., methadone or buprenorphine) * fulfills dsm-iv diagnostic criteria for opioid dependence exclusion criteria: * significant medical problems, including insulin dependent diabetes mellitus * non-substance use psychiatric disorders (e.g., schizophrenia) * currently seeking treatment for substance abuse
transcutaneous pulsed radiofrequency in diabetic polyneuropathy

Conditions: Neuropathy;Peripheral

Summary: investigators want to investigate the efficacy of transcutaneous pulsed radiofrequency therapy in the treatment of diabetic peripheral neuropathy symptoms. for this purpose, investigators aimed to compare the results of two groups treated with sham electrode and active electrode.

peripheral neuropathic pain is common in diabetes mellitus. distal symmetrical polyneuropathy is the most common form. these patients have complaints such as burning, freezing, tingling and pain in their hands and feet. peripheral nerve blocks or sympathetic blocks are applied to patients who cannot be treated with medical agents. transcutaneous pulsed radiofrequency is a method used in the treatment of pain. the advantages of transcutaneous pulsed radiofrequency method are that it is not invasive, does not cause side effects, and does not interact with drugs. we want to investigate the efficacy of diabetic peripheral neuropathic pain treatment with this method. sixty diabetic polyneuropathy patients will be included in the study. transcutaneous pulsed radiofrequency therapy with active electrode will be applied to half of the patients. sham electrode will be used for the other half. patients will not know which group they belong to. two treatments will be applied with 7 days intervals. the duration of treatment will be 8 minutes.each patient will receive a leeds assessment of neuropathic symptoms and signs questionnaire (lanss). before the treatment, in the first month and third month after the treatment, the patients will be filled with a visual analog scale. the results between both groups will be statistically compared.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of diabetes mellitus * peripheric neuropathy with proved electroneuromyography exclusion criteria: * additional endocrinological disease, * pregnancy, malignancy, motor deficit in lower extremities

Keywords: neuropathic pain transcutaneous pulsed radiofrequency
acute effects of foam rolling on viscoelastic tissue properties and fascial sliding

Conditions: Fascia; Self-Myofascial-Release; Passive Stiffness; Fascial Sliding; Flexibility

Summary: treatment or training of fascial tissues has moved into the focus of medical research in the last decade. in this context, the use of foam rollers or roller massagers for self-myofascial-release (smr) techniques has become increasingly popular in health and fitness professionals. the primary objective of these techniques is to mimic manual massage or myofascial-release therapy with a self-usable tool. recent studies suggest that smr improves, inter alia, range of motion (rom) without a decrease in neuromuscular performance (cheatham et al. 2015). concurrent effects on the muscle and especially the surrounding connective tissue network have been proposed as underlying mechanisms for these observed changes in rom after smr. several authors assume a positive effect of smr on sliding properties of different independent fascial layers. also, changes in passive tissue stiffness is suggested. passive stiffness is thereby characterized by passive resistance in the tissues' (muscles') functional direction, the passive resistive torque (prt). in conclusion, for many of the proclaimed effects of smr, such as improvements of sliding of fascial layers or decreases of passive stiffness, there is a lack of evidence in the literature. therefore, the aim of the study is to evaluate acute effects of smr on the viscoelastic properties of the muscles on the anterior thigh and the corresponding fascia. in a cross over design, 16 subjects receive all of the following interventions after a familiarization session: a) 2x60 seconds of smr at the anterior thigh, b) 2x60 seconds of static stretching at the anterior thigh, c) no intervention in a balanced permutated randomization sequence. before and directly after each intervention, outcome parameters are collected. passive resistive torque is evaluated using a computerized isokinetic dynamometer. in passive mode, the lower leg is moved from full knee extension (0°) to the point of maximal knee flexion with a velocity of 5°/s. torque and angle are recorded at 100 hertz (hz). sliding of fascial layers is quantified with a frame-by-frame cross correlation algorithm of high-resolution ultrasound images (dilley et al. 2001). first stretch sensation is quantified using the passive mode in the isokinetic dynamometer. maximal rom is detected using a an ultrasonographic movement analysis system in a prone position.


Eligibility criteria:
inclusion criteria: * age between 20-40 years exclusion criteria: * history of orthopedic injuries in the lower extremity in the last 12 months * any history of psychiatric, cardiovascular, endocrine, neurological, or metabolic disorders * any current medication that might affect pain perception or proprioception * muscle soreness * pregnancy/nursing period * nonspecific musculoskeletal disorders