Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of intravenous to oral 6-day tedizolid phosphate vs. intravenous to oral 10-day linezolid in patients with acute bacterial skin and skin structure infection (absssi)

Conditions: Bacterial Infections

Summary: this study is aimed to evaluate the efficacy and safety between tedizolid 200mg daily (intra venous) i.v. to oral for 6-day treatment compared with that of linezolid 600mg twice daily i.v. to oral for 10-day treatment acute bacterial skin and skin structure infection (absssi).this is a double-blind, randomized, active control, 7-10days treatment for all subjects.

number of participants with adverse evnets as a measure of safety and tolerability will be covered in adverse events section. absssi efficacy safety tedizolid phosphate linezolid

Eligibility criteria:
inclusion criteria: * males or females \>/=18 years old * adequate venous access for a minimum of 2 i.v. doses of study drug * acute bacterial skin and skin structure infection (absssi) meeting at least 1 of the clinical syndrome definitions listed below and requiring i.v. antibiotic therapy. local symptoms must have started within 7 days before the screening visit * cellulitis/erysipelas * major cutaneous abscess * wound infection * suspected or documented gram-positive infection from baseline gram stain or culture. exclusion criteria: * uncomplicated skin and skin structure infections such as furuncles, minor abscesses * infections associated with, or in close proximity to, a prosthetic device * severe sepsis or septic shock * known bacteremia at time of screening * absssi due to or associated with any of the following: * suspected or documented gram-negative pathogens in patients with cellulitis/erysipelas or major cutaneous abscess that require an antibiotic with specific gram-negative coverage. patients with wound infections where gram-negative adjunctive therapy is warranted may be enrolled if they meet the other eligibility criteria * diabetic foot infections, gangrene, or perianal abscess * concomitant infection at another site not including a secondary absssi lesion (eg, septic arthritis, endocarditis, osteomyelitis) * infected burns * decubitus or chronic skin ulcer, or ischemic ulcer due to peripheral vascular disease (arterial or venous) * any evolving necrotizing process (ie, necrotizing fasciitis) * use of antibiotics as follows: * systemic antibiotic with gram-positive cocci activity for the treatment of any infection within 24 hours before the first infusion of study drug * patients who failed prior therapy for the primary infection site are also excluded from enrollment * topical antibiotic on the primary lesion within 24 hours before the first infusion of study drug except for antibiotic/antiseptic-coated dressing applied to the clean postsurgical wound * administration of linezolid within 30 days before the first infusion of the study drug * recent history of opportunistic infections where the underlying cause of these infections is still active (eg, leukemia, transplant, acquired immunodeficiency syndrome \[aids\]) * previous exposure to tedizolid phosphate treatment
outcomes of partial versus complete tonsillectomy for obstructive sleep disordered breathing

Conditions: Obstructive Sleep Disordered Breathing

Summary: introduction: there is currently no long-term study, which compares the outcomes of partial tonsillectomy to conventional tonsillectomy. we hypothesize that there will be little significant tonsillar regrowth with partial tonsillectomy. background and significance: tonsillectomy is the most common major surgical procedure performed on children in the united states with nearly 300,000 procedures performed each year, primarily for the indication of obstructive sleep disordered breathing (osdb). conventional (total) tonsillectomy removes the tonsillar capsule, and partial tonsillectomy preserves the capsule by shaving away the tonsils using an endoscopic microdebrider. partial tonsillectomy results in less pain, fewer days to normal activity and diet, and fewer days of analgesics than total tonsillectomy. there are no significant differences between the techniques in blood loss or postoperative life improved historical evidence suggests that eventually there will be tonsillar regrowth with partial tonsillectomy. however, in a 2003 follow-up report of 243 children undergoing partial tonsillectomy and 107 undergoing complete tonsillectomy from 1998 through 2002 for osdb there was no evidence of significant tonsillar regrowth. (1) we will follow-up children undergoing partial or complete tonsillectomies at the cleveland clinic from 1998 through 2002. there will be standardized tonsillar examinations by two observers, with a third observer in cases of significant disagreement, and questionnaires evaluating sleep apnea and daytime sleepiness, and number of tonsillar infections. if there are a large number of children with recurrent tonsillar symptoms post partial tonsillectomy, the procedure should be abandoned. however, if follow-up reveals comparable tonsillar symptoms for partial and the total tonsillectomy, perhaps the partial procedure should replace the total tonsillectomy as the standard operation to relieve tonsillar osdb. this could eventually result in millions of less lost days of work and school in the united states.


Eligibility criteria:
inclusion criteria: * pediatric patients undergoing tonsillectomies at the cleveland clinic from 1998-2002

Keywords: partial tonsillectomy complete tonsillectomy tonsillectomy obstruction sleep disordered breathing osdb apnea
predictors of recurrence for high risk endometrial cancer patients

Conditions: High-risk Endometrial Cancer

Summary: this study will analyze whether there is any difference in recurrence and survival rates among the patients who received different adjuvant therapies.

the incidence of endometrial cancer is gradually increasing nowaday. the postoperative treatment of high-risk endometrial cancer is also inconsistent. besides, the recurrence of high-risk endometrial cancer is high.the investigators retrospective study will analyze the factors associated with recurrence of endometrial cancer, especially for different adjuvant therapies.

Eligibility criteria:
inclusion criteria: * all patients with high risk stage i endometrial cancer and all patients with stage ii and stage iii endometrial cancer and who underwent therapy in far eastern memorial hospital from 2009/01/01\~2019/09/17. exclusion criteria: * patients with stage i endometrial cancer do not have high risk factors.
safety study of azd5672 in renally impaired subjects

Conditions: Renal Impairment

Summary: the purpose of the study is to investigate the pharmacokinetics of a single dose of azd5672 in patients with renal impairment by comparing with healthy volunteers


Eligibility criteria:
inclusion criteria: * provision of signed written informed consent. * females should not be of childbearing potential * subjects classified as renally impaired should have been stable (in the investigator's opinion) for at least 3 months prior to visit 1. exclusion criteria: * patients taking prescription of medications: pgp substrates, inhibitors and /or inducers, medications that affect creatinine clearance(within 7 days of dosing), atorvastatin \>20mg once daily, medications that prolong qt/qtc interval * change in dose regimen of prescribed medication and nsaids within the 2 weeks before enrolment (renal patients only) * participation in another clinical study involving administration of an investigational product in the 3 months prior to treatment (or within 5 half-lives of the last dose of the investigational product, whichever is longer)

Keywords: azd5672
effects of a structured occupational therapy intervention in an acute geriatric unit

Conditions: Occupational Therapy

Summary: objectives: to compare the benefits of structured occupational therapy intervention by a single geriatric therapist with the benefits of the conventional treatment model in the functional recovery of patients admitted to an acute geriatric unit. design: non-pharmacological randomised clinical trial. setting: acute geriatric unit, albacete, spain. participants: the trial included 400 patients admitted consecutively over 6 months to an acute geriatric unit for acute illness or exacerbation of a chronic medical condition. participants were randomised to the occupational therapy intervention or conventional treatment model group; 198 patients received occupational therapy. all patients completed the study. the mean age was 83.5, and 56.8% were women. interventions: needs assessment, iatrogenic prevention, retraining in basic and instrumental activities of daily living, assessment of need for technical aids, instruction for primary caregiver in patient mobilisation techniques, and structured social and occupational motivation as per protocol in three groups of patients (cardiopulmonary disease, stroke, and other conditions) 5 days a week, 30 to 45 minutes a day over the entire hospital stay.


Eligibility criteria:
inclusion criteria: * all patients age 65 or older consecutively admitted to the acute geriatric unit at the complejo hospitalario universitario in albacete, spain, between november 2002 and june 2003 for an acute medical illness or exacerbation of a previous chronic condition exclusion criteria: * none

Keywords: occupational therapy randomised clinical trial aged patient care
the effects of cervical sensorimotor control challenges on gait patterns, cervical sensorimotor control during dynamic tasks

Conditions: Neck Pain; Sensorimotor; Gait

Summary: to investigate the influence of cervical smc challenges during gait-related dynamic tasks on all task performance and symptoms in patients with cnp.

the goal of this observational study is to learn about the immediate effects of cervical sensorimotor challenges during gait-related dynamic tasks on all task performance and symptoms in patients with cnp . the main question it aims to answer is: does adding sensorimotor challenges in chronic neck pain patient will affect balance and gait performance?

Eligibility criteria:
inclusion criteria: * healthy asymptomatic adults will not have any complaints of current pain and impairments of neuromusculoskeletal systems within the last 6 months. * for patients with cnp * pain was unilateral or bilateral between the superior nuchal line and 1st thoracic vertebra * neck pain persisting for 3 months and above * average pain intensity of last pain episode was between 2 and 8 based on the numeric rating scale (nrs). exclusion criteria: ◾for patients with cnp and healthy asymptomatic adults * acute or the first onset of neck pain * traumatic cause of pain * previous fracture or surgery of the spine * diagnosed cardiopulmonary diseases, for example, chronic obstructive pulmonary disease, pulmonary tuberculosis, asthma, chronic bronchitis, pulmonary emphysema * diagnosed gastrointestinal and abdominal conditions which may interfere daily activities within the past 6 months * medical conditions that may affect balance and study procedures (e.g. neurological diseases, vestibular disorders, malignant tumors) * metabolic diseases such as anemia and diabetes * smoking, plan to pregnant or in pregnancy * psychological disorders (affect questionnaire responses) * unable to walk independently * corrected visual abnormalities or individuals unable to wear contact lenses for vision correction due to the potential interference of wearing vr head-mounted display with glasses.

Keywords: sensorimotor control chronic neck pain oculomotor control gait balance
predictors and prognostic factors on the acute ischemic stroke

Conditions: Ischemic Stroke

Summary: through 5 years continuous observation of acute ischemic stroke patients in neurology department of tongji hospital, tongji medical college of huazhong university of science and technology, clinical data about emergency treatment (neurological score, examination and treatment), medical data after admission (neurological score, inspection, examination and treatment) and long-term prognosis (neurological score) was collected. the outcomes were set as the score scale, all blood test index and examination index of the research objects at specific period after illness. through statistical analysis and comparison of different in-hospital clinical data in predicting the outcome of the patients, our study will provide more evidence-based solutions for the treatment and prediction of acute ischemic stroke.

the research is designed as registrated, prospective, open-labeled, blind-endpoint, and the research objects are continuously recorded. the final subgroups are blind to neurological evaluators, data inputers and statisticians. the research is a continuous observational exploratory study. all patients with ischemic stroke admitted to tongji hospital, tongji medical college of huazhong university of science and technology from april 1, 2017 to december 31, 2021 will be included. according to the current situation, it is expected to enroll approximately 5000 of eligible patients for long-term follow-up observation. we'll use multiple linear regression analysis model to study factors and confounding factors and their interaction. and we will control the confounding factors, and make a quantitative description of the relationship between factors and outcome variables. missing cases will be treated as censored values, and the ratio of missing cases will be recorded. all samples will be analyzed by intent-to-treat (itt) analysis. in the analysis, if the results are statistically significant, the missing cases in the exposed group will be deleted, and the missing cases in non-exposure group be added. if the results are still statistically significant, then the missing cases are defined as not affecting the analysis results. if the heterogeneity of data is large, the objects will be analyzed in subgroups according to age or sex. if the missing rate is greater than 20%, it is necessary to analyze the sensitivity of the whole sample.

Eligibility criteria:
inclusion criteria: * ≥18 years old, of either sex * confirmation by ct scan * willingness to participate in the study and comply with its procedures by signing a written informed consent exclusion criteria: * cerebral hemorrhagic infarction confirmed by ct scan * patients with severe systemic disease who are expected to survive for no more than three months * unwilling to participate in the study

Keywords: ischemic stroke cerebral infarction cerebrovascular disorders
study of effects of sildenafil on patients with fontan heart circulation

Conditions: Single Ventricle Heart Disease After Fontan Surgery

Summary: the study will investigate the cardiovascular effects of sildenafil on patients with fontan circulation. recent studies suggest that sildenafil may improve exercise in patients with fontan circulation. however, why this occurs is not known. the study will used specialized catheters to measure pressure and volume. the measure of pressure and volume leads to more detailed analysis of heart function. patients will receive either sugar pill or sildenafil prior to catheterization. it is believed that sildenafil will improve relaxation and contraction of the heart.

modifications to surgical procedures and medical treatment have led to a rapidly declining mortality rates in patients with single-ventricle heart disease (sv). however, sv patients still suffer from lower quality of life, decreased exercise capacity, worse neurodevelopmental outcomes and many other morbidities. while patients with sv circulation only make a small portion of all congenital heart diseases, 2-4 %, they require a great deal of resource utilization. standard medical treatments for adult heart failure have not had the same success in the sv population. phosphodiesterase 5 (pde5) inhibitors have recently become a frequently used medication class in patients with sv heart disease to treat pulmonary hypertension, heart failure, as well as "fontan" failure (i.e., plastic bronchitis and protein-losing enteropathy). while there have been findings of improved measures of exercise capacity and some reports of improved symptoms of heart failure, the physiologic mechanisms behind these findings are not completely understood. there have been reports, indicating that the phosphodiesterase five inhibitors improve ventricular function in biventricular circulation patients and animal models. the aim of our study was to investigate the effect of acute pde5 inhibition on ventricular function in sv patients after the final palliative surgery, the fontan procedure.

Eligibility criteria:
inclusion criteria: * presence of a congenital heart defect that leads to single ventricle physiology * previously performed fontan surgery exclusion criteria: * the use of phosphodiesterase type 5 (pde5) inhibitors at the time of catheterization of within 1 month of catheterization * unstable arrhythmia at the time of catheterization * history of unstable arrhythmia within 2 months of catheterization * venous, arterial or cardiac malformation that precludes the proper placement of a microconductance catheter * allergy to sildenafil or previous significant adverse reaction to sildenafil (e.g. hypotension)

Keywords: single ventricle fontan sildenafil pressure-volume loops
evaluation of circulating tumor cells (ctc) relevance in breast cancer follow-up using the screencell device

Conditions: Breast Cancer, Metastatic; Breast Cancer Invasive; Breast Cancer Early Stage Breast Cancer (Stage 1-3)

Summary: liquid biopsy is a noninvasive method for detecting and quantifying circulating tumor cells (ctcs). thanks to screencell technology, this study aims to evaluate the evolution of the number of ctcs during breast cancer follow-up. the identification and characterization of ctcs would make it possible to obtain information on the stage and molecular characteristics of cancer during follow-up


Eligibility criteria:
inclusion criteria for all participants : * age greater than or equal to 18 years for participants with metastatic breast cancer: - patient observed with metastatic breast cancer from the outset or metastatic fall from previously treated breast cancer with change of therapeutic line at the time of inclusion. for participants with non-metastatic invasive breast cancer: - patient observed with non-metastatic infiltrative breast cancer who had not received any treatment at the time of inclusion (naïve to any treatment) for healthy volunteers: * participant free of any cancer at the time of inclusion, confirmed using a mammogram whose results must be satisfactory, done at the latest one year before inclusion * participant with no history of cancer exclusion criteria for all participants: * age less than 18 years old * refusal to participate or withdrawal of consent * pregnant and/or breastfeeding women * discovery of a cancerous pathology (other than breast cancer for patients) during participant follow-up. for participants with breast cancer: - absence of ctc during screening for healthy volunteers: * history of cancer * detection of ctc (positive profile) during screening

Keywords: ctc circulating tumor cells detection breast cancer follow-up liquid biopsy blood test
diagnostic tools to establish the presence and severity of peripheral arterial disease in people with diabetes

Conditions: Diabetic Foot; Peripheral Arterial Disease; Diabetic Foot Ulcer; Peripheral Vascular Diseases; Peripheral Artery Disease; Critical Limb Ischemia; Critical Lower Limb Ischemia

Summary: in the uk there are over 7,000 leg amputations each year because of diabetes. the most important cause of this is poor circulation. the detection of poor circulation in patients with diabetes is difficult. a number of tests exist to detect poor circulation (known as peripheral arterial disease (pad)). however, there is confusion as to which is the gold standard. the dm pad study aims to determine the diagnostic performance of index tests (audible handheld doppler, visual handheld doppler, ankle brachial pressure index (abpi), exercise abpi and toe brachial pressure index (tbpi)) for the diagnosis of pad in patients with diabetes as determined by a reference test (cta or mra).


Eligibility criteria:
inclusion criteria: * aged ≥18 years * known history of diabetes exclusion criteria: * pad status known on imaging * known history of pad intervention * cta and mra contraindications- renal impairment, pregnancy, contrast medium hypersensitivity/allergy, non-compatible implants (mra only). * unable to provide appropriate informed consent.
integrated coping and awareness training

Conditions: Schizophrenia

Summary: integrated coping and awareness therapy is a novel therapeutic intervention combining strategies to improve stress reactivity and increase meaningful coping, as well as a range of possible proximal (e.g. immune indices of stress reactivity, symptom severity) and distal measures (e.g. relapse, quality of life).

schizophrenia is one of the most devastating disorders that often results in a lack of functional recovery. current treatments focused on remediating symptoms have shown only small successes in a return to functioning despite evidence of a dysregulated stress response. there is a fundamental gap in understanding the impact of allostatic overload in persons with schizophrenia that the investigators theorize is associated with deficits in functioning and with an increased vulnerability and relapse risk. the long-term goal is to test an intervention aimed at improving stress reactivity. the objective in this application is to develop and test the feasibility of a novel therapeutic intervention combining strategies to improve stress reactivity and increase meaningful coping. the central hypothesis is that an intervention that improves stress reactivity as measured proximally by endocrine, immune, and autonomic indices will result in improved adaptive capacity, better role functioning, reduced risk of relapse, and decreased likelihood of disability for people in the early stages of schizophrenia. the rationale for the proposed research is that stress reactivity may be a modifiable risk factor underlying functional deficits in schizophrenia. the intervention integrates two treatment approaches. the first is based on research showing that mindfulness meditation practice is associated with alterations in the neural processing of stressful events and targets adaptive responses to stress. the second focuses on providing a buffer against stress by using the self-generation of adaptive emotions with a positive psychology intervention, which is potentially associated with building protective social resources. these complimentary interventions provide a comprehensive synergistic approach for this population that could lead to more adaptive coping responses and create a buffer against stress.

Eligibility criteria:
inclusion criteria: * current or past diagnosis of a schizophrenia spectrum disorder. * has been receiving treatment for psychosis or taking medication for psychosis for less than 5 years. exclusion criteria: * has been hospitalized in the last 3 months. * currently practicing meditation * current dependence on alcohol or drugs. * history of significant neurological disorder. * history of serious head injury (i.e., loss of consciousness longer than 15 minutes, no neuropsychological sequelae, no cognitive rehabilitation treatment post head injury). * illiteracy. * sensory limitation including visual (e.g., blindness, glaucoma, vision uncorrectable to 20/40) or hearing (e.g. hearing loss) impairments.

Keywords: schizophrenia treatment meditation mindfulness stress reactivity first episode psychosis coping