Kornimate/medical-research-clean huggingface dataset:
melatonin and adiponectin in hypertensive kidney transplant

Conditions: Hypertension; Kidney Transplant

Summary: recently we have shown that melatonin secretion is impaired in rats with metabolic syndrome. we have also demonstrated that exogenic melatonin supplementation can improve blood pressure profile in nondipper patients. the aim of this study is to find whether there is a difference between melatonin secretion in hypertensive kidney recipients versus "normal" hypertensive patients. secondly, to ask if there is any correlation between melatonin secretion and adiponectin levels.


Eligibility criteria:
inclusion criteria: * hypertension * kidney transplantation ( group 1) * good renal function exclusion criteria: * diabetes mellitus * cancer * renal failure

Keywords: hypertension kidney transplant melatonin adiponectin
the brain and lung interaction (bali) study

Conditions: Intracranial Pressure; Mechanical Ventilation; Brain Injuries

Summary: the purpose of this study is to understand the relationship between intracranial pressure and airway pressures during mechanical ventilation. this study is a single-center, prospective cohort study to be conducted at beth israel deaconess medical center. the investigators will recruit patients with severe brain injury (gcs 8 or less) who receive intracranial pressure monitoring and mechanical ventilation as part of their routine medical care. the primary endpoint is the change in intracranial pressure as a function of positive end-expiratory pressure. there is only one study encounter with safety monitoring for up to 24 hours after. no additional follow up is required.


Eligibility criteria:
inclusion criteria: - patients with severe brain injury (gcs 8 or less) who receive both mechanical ventilation and intracranial pressure monitoring as part of their standard medical care will be considered eligible. exclusion criteria: * patients with esophageal varices * patients with esophageal trauma * patients with recent esophageal surgery * patients with coagulopathy (platelets \ 2 ) * other contraindication for esophageal manometry * patients who are receiving peep greater than 15 cmh2o within 24 hours prior to enrollment * intracranial hypertension (defined as icp greater than 20 mmhg) within 48 hours prior to enrollment * decompressive hemi-craniectomy cessation criteria: study related ventilator adjustments and measurements will be stopped at any point during the intervention and ventilator settings will be returned to the pre-intervention settings under the following conditions: * if icp increases above 20mmhg, regardless of the duration of the event. * if systolic blood pressure decreases below 90mmhg, regardless of the duration of the event. * if systolic blood pressure increases above 180mmhg, regardless of the duration of the event.
protocol in reeducation occupational therapist in coronary patients

Conditions: Myocardial Infarction; Coronary Artery Disease

Summary: the quality of life, linked to physical, social and mental performance in people with coronary heart disease represents the primary goals in terms of rehabilitation. this is often developed to meet the expected performance standard in order to give the person effective autonomy. however, is the occupational balance always evaluated? and this management adapted? does occupational therapist, expert in autonomy and independence in multiple illnesses and disabilities, has a major role to play in cardiac rehabilitation? this area of expertise and the application of occupational therapy to coronary patients seems appropriate, if not necessary. however, there are few scientific studies on the need to include occupational therapy within cardiac rehabilitation protocols.

the occupational therapy goals are in line with the theoretical objectives of coronary rehabilitation. at present, there is a lack of data on the benefits of coronary occupational therapy rehabilitation. goals : evaluation of the quality of life of coronary heart patients who have benefited from cardiac rehabilitation optimized by secondary occupational therapy sessions: evaluation of aerobic and anaerobic performance of coronary heart patients who have benefited from cardiac rehabilitation optimized by occupational therapy sessions. evaluation of aerobic and anaerobic performance of coronary heart patients who have benefited from cardiac rehabilitation optimized by occupational therapy sessions.

Eligibility criteria:
inclusion criteria: * coronary artery disease * included in the cardiac rehabilitation protocol in saint etienne university hospital exclusion criteria: * patients who not perform all sessions of the cardiac rehabilitation protocol

Keywords: occupational therapy quality of life
home-based exercise in chronic kidney disease

Conditions: Chronic Kidney Disease; End-stage Renal Disease

Summary: a home-based exercise program will be implemented in three different groups of participants: advanced chronic kidney disease, end-stage renal disease in substitutive treatment hemodialysis or peritoneal dialysis. participants will be evaluated before the program, after 3 months and after 6 months from the starting of the program. during the first 3 months the researcher will phone them weekly to reinforce the exercise habit, and during the last three months, there will be no reinforcement. assessment will include strength, functional capacity, health-related quality of life and depressive symptoms.

three groups of participants (advanced chronic disease not yet in substitutive treatment, end-stage renal disease patients in hemodialysis and end-stage renal disease patients in peritoneal dialysis) will enter the study. the intervention will consist of a home-based exercise program. they will be provided with a booklet and the researcher will explain personally each of the exercises to the participants. progression will be encouraged so that the participants should find the sessions 'somewhat hard' according to the rate of perceived exertion. reinforcement will be high during the first 3 months (weekly phone calls, visits to the nephrology department) and none during the last 3 months. assessment will be undertaken at three-time points: baseline, after 3 months of high reinforcement and after 3 more months of no reinforcement at all. assessment will include strength, functional capacity, health-related quality of life, cognitive state and depressive symptoms. the aim of the study is to assess the effectiveness of home-based exercise to improve strength, physical function, health-related quality of life, cognitive state and depressive symptoms in advanced chronic kidney disease and end-stage renal disease (hemodialysis and peritoneal dialysis). we also aim at describing all these variables in the three different groups of patients. adherence and satisfaction with the exercise program will be recorded at the end of the study. additionally, interobserver reliability will be calculated, so as reliability intraobserver in different measurement conditions (dialysis vs non-dialysis days).

Eligibility criteria:
inclusion criteria: * at least 3 months in hemodialysis treatment * clinically stable exclusion criteria: * recent cardiac events (less than 3 months) * unable to exercise

Keywords: exercise health-related quality of life physical function hemodialysis peritoneal dialysis
non-invasive prediction of thermal strain in healthy male adults

Conditions: Heat Stress

Summary: this is primarily an experimental study investigating methods of temperature measurement / heat strain detection. in the calibration study, there are different skin temperature sensor types, and in the prediction study there are different methods for determining heat strain, including conventional methods (rectal, gastro-intestinal), the development of a prediction model, and an index based on heart rate variability.


Eligibility criteria:
inclusion criteria: * apparently healthy males * aged 18-45 y * regularly participate in sport, exercise, or equivalent physical activity on a weekly basis. exclusion criteria: * known injuries or illnesses that may affect safe participation. these include injuries or illnesses involving (but not limited to): * cardiovascular, renal, or gastrointestinal tract * heat or exercise intolerance * acute infections, * immunological diseases (including asthma) * psychiatric disorders. * participants must not be currently or previously on cardiovascular-related medication and must not be taking psychotropic medication (last 60 days).
first line therapy for high risk acute gvhd

Conditions: aGVHD; Stem Cell Transplant Complications

Summary: the purpose of this study is to determine the efficacy and safety of combined ruxolitinib with corticosteroids as first line therapy for the treatment of high risk agvhd(acute graft-versus-host disease )

acute graft-versus-host disease (agvhd) is treated with systemic corticosteroid immunosuppression as first line therapy. many patients with high risk agvhd do not respond to primary therapy, high-dose systemic corticosteroids; therefore, survival for those patients remains particularly poor. here we determine the efficacy and safety of combined ruxolitinib with corticosteroids as first line therapy for the treatment of high risk agvhd.

Eligibility criteria:
inclusion criteria: 1. diagnosed with hematological diseases. 2. have undergone first allogeneic hematopoietic stem cell transplantation (allo-hsct) from any donor source using bone marrow, peripheral blood stem cells, or cord blood for hematologic malignancies. 3. new onset of grade ii\~iv agvhd or intermediate or high risk agvhd (based on st2, reg3a, other experimental objects) within 100 days post-transplantation. exclusion criteria: 1. recipients of second allogeneic stem cell transplant. 2. acute gvhd induced by donor lymphocyte infusion, interferon. 3. received first line agvhd treatment before enrollment. 4. overlap gvhd syndrome. 5. pregnant or breast-feeding women. 6. absolute neutrophil count (anc) \<0.5×10e9/l or platelet count (plt) \< 20×10e9/l 7. serum creatinine \> 2.0 mg/dl or creatinine clearance \< 40 ml/min measured or calculated by cockroft-gault equation. 8. uncontrolled infection 9. human immunodeficiency virus infection 10. active hepatitis b virus, hepatitis c virus infection and need antivirus treatment. 11. subjects with evidence of relapsed primary disease, or subjects who have been treated for relapse after the allo-hsct was performed, or graft rejection. 12. allergic history to janus kinase inhibitors. 13. severe organ dysfunction unrelated to underlying gvhd, including: cholestatic disorders or unresolved veno-occlusive disease of the liver (defined as persistent bilirubin abnormalities not attributable to gvhd and ongoing organ dysfunction). clinically significant or uncontrolled cardiac disease including unstable angina, acute myocardial infarction within 6 months from day 1 of study drug administration, new york heart association class iii or iv congestive heart failure, circulatory collapse requiring vasopressor or inotropic support, or arrhythmia that requires therapy. clinically significant respiratory disease that requires mechanical ventilation support or 50% oxygen. 14. received janus kinase inhibitor therapy after allo-hsct for any indication. 15. any condition that would, in the investigator's judgment, interfere with full participation in the study, including administration of study drug and attending required study visits; pose a significant risk to the subject; or interfere with interpretation of study data.

Keywords: agvhd
protective ventilatory strategy in potential organ donors

Conditions: Mechanical Ventilation

Summary: the aim of the study is to verify if a "protective" ventilatory strategy (low tidal volume and high peep, application of cpap during the apnea test and recruitment maneuvers), improves lung function and increases the number of lungs eligible for transplantation.

lung transplantation reduces mortality in patients with severe pulmonary diseases. while 50-70% of kidney, liver and heart are eligible for transplantation, only 20% of the lungs fit the criteria for transplant. more than 30% of the lungs theoretically suitable for donation are not actually collected because following brain death they develop severe hypoxemia and abnormal chest x-ray. guidelines for critical care management of potential organ donors suggest that after the diagnosis of brain death, treatment priority can be shifted from cerebral protection to a strategy aimed at preserving solid organ perfusion and function. however the ventilatory strategy recommended for potential lung donors is similar to the one proposed for brain injured patients. this ventilatory strategy based on high vt and low peep may induce a further exacerbation of the pulmonary and systemic inflammatory response in patients with acute lung injury/acute respiratory distress syndrome. moreover, recent data suggest that this strategy may be harmful in "normal lungs" of mechanical ventilated patients. aim of the study is to verify if a "protective" ventilatory strategy (low tidal volume and high peep, application of cpap during the apnea test and recruitment maneuvers) improves lung function. primary end point of the study is to increase the number of lungs that meet the eligibility criteria for transplantation. secondary end point is to increase the number of lungs really transplanted.

Eligibility criteria:
inclusion criteria: * age: 18-65 years * chest x-ray: no infiltrates * duration of mechanical ventilation from the admission to icu to the clinical diagnosis of brain death \< 5 days * no history of smoking (1 pack/day for 20 years; 1/2 pack/day for 40 years; 2 packs/day for 10 years) * no history of asthma * no history of copd * no history of trauma * no history of thoracic surgery exclusion criteria: * evidence of aspiration (chest x-ray or bronchoscopy) or sepsis * purulent secretions (tracheal suction or bronchoscopy) * sputum gram stain with bacteria, fungus, significant number of wbc

Keywords: brain death lung transplantation organ donors potential organ donors
the hiv functional cure potential of ub-421 in art stabilized hiv-1 patients

Conditions: HIV-1 Infection

Summary: this study evaluate the safety of ub-421 in combination with standard antiretroviral therapy (art) and the efficacy of hiv reservoir reduction as compared with art alone in art stabilized hiv-1 patients


Eligibility criteria:
inclusion criteria: 1. hiv-1 sero-positive 2. male with body weight ≥ 50 kg or female with body weight ≥ 45 kg. 3. hiv-1 plasma rna level below 50 rna copies/ml . exclusion criteria: 1. subjects with active systemic infections, except for hiv-1, that the investigator feels the infections may confound evaluation and treatment for hiv-1. 2. current active hepatitis b carriers, ie, hepatitis b surface antigen positive. 3. current active hepatitis c carriers, ie, hepatitis c virus (hcv) antibody positive. 4. history of anaphylaxis to other mabs. 5. any vaccination within 8 weeks prior to the first dose of assigned drug. 6. use of immunomodulators, hiv vaccine, or systemic chemotherapy within 180 days prior to the first dose of assigned drug. 7. females who are pregnant, lactating, or breastfeeding, or who plan to become pregnant during the study.
recording "fast ripples" using microelectrodes during stereo-encephalography in patients with drug-resistant partial epilepsy

Conditions: Epilepsy

Summary: the main objective of this study is to evaluate the feasibility of recording fast-ripples, a potential new biomarker of epilepsy, using the new micro-macroelectrodes developed by dixi-medical.

partial epilepsies are refractory to medical treatment in 30% of the cases (refractory partial epilepsy or rpe). patients with rpe suffer from social and occupational disability, an increased risk associated with seizures (traumatic brain injury, accidents), but also a higher risk of sudden unexplained death (2 to 3 times higher) than the general population. moreover, the medical and social burden of these patients is heavy, representing a significant cost to society. in some cases, surgical treatment with resection of the epileptogenic zone (ez) can be proposed. the presurgical evaluation includes various investigations seeking to clarify the location of the ez; but this approach is sometimes insufficient and the definition of the ez then requires invasive exploration through intracerebral eeg recording (stereo-eeg, seeg). this latter technique is currently the preferred standard to define the ez. it involves implanting electrodes in the brain areas suspected to belong to the seizure network. 50 to 70% of patients investigated with this technique will have epilepsy surgery. in recent years, a series of studies in animals and humans have suggested that some oscillations, very short and at very high frequency (\> 250 hz), called "fast ripples" (frs) could be a good biomarker of the ez (for a review see zijlmans et al, 2012). the frs are more easily recorded from microelectrode (diameter: 20-40 microns). the purpose of this study is to evaluate a new medical device designed by diximedical to record frs, combining micro and regular clinical electrodes.

Eligibility criteria:
inclusion criteria: * patient with rpe in whom seeg is required to precisely localize the seizure focus exclusion criteria: patients with seeg contra-indication: * severe psychiatric disorders, * severe agitation during their crisis * contraindication for performing an mri: claustrophobia, a cardiac or neural stimulator, ferromagnetic surgical clips, cochlear implants, intraocular metallic foreign body or in the nervous system, * contraindication to intracerebral investigation (macro-electrodes): ongoing infection, severe associated pathology (cardiac, pulmonary, renal, hepatic), pregnant or nursing women, * anti thrombotic ongoing treatment.

Keywords: safety electrodes device stereoelectroencephalograph epileptogenic zone fast ripples
text message-based nudges prior to primary care visits to increase care gap closure

Conditions: Pneumonia, Pneumococcal; Diabetes Mellitus; Breast Cancer; Colorectal Cancer

Summary: primary care visits are a key aspect of clinical care focused on helping patients to close care gaps related to preventive care such as vaccination, diabetes testing, statin therapy and cancer screening. however, less than 50% of care gaps are closed during these visits and new approaches are needed to prime patients for a discussion during these visits. in this study, the study team will evaluate a health system initiative that uses text messaging to patients in days preceding a primary care visit to prime patients to be amenable to ordering of vaccination, diabetes testing, cancer screening, and statin prescribing.

the united states preventive services task force has recommended tests and treatments for vaccination, diabetes testing, statin therapy, and cancer screening. these preventive services have been demonstrated to reduce illness and improve quality of care. yet, more than 50% of open care gaps go unaddressed during primary care visits. nudges are subtle changes to the way information is framed or choices are offered that can have a significant impact on behavior. in a previous randomized clinical trial, text messages sent to patients prior to primary care visits increased vaccination by up to 11% relative to control. the most effective message told patients the influenza vaccine was "reserved for you," and sent two text messages to patients in the 3 days preceding a primary care appointment.

Eligibility criteria:
inclusion criteria: * age 18 or older * have documented consent to communicate electronically * have a visit scheduled with a primary care practice * have at least one open care gap among those in the intervention exclusion criteria: * no phone number on file to send text messages
acute episodes in chronic stable angina: assessment of the use of the coronary vasodilator propatyl nitrate.

Conditions: Chronic Stable Angina Pectoris

Summary: this is an open, self-paired study of 200 patients with heart failure who have a diagnosis of chronic stable angina pectoris, who will be treated for 30 days with propatyl nitrate (10mg) . treatment regimen is 3 sublingual tablets per day, at 8:00 am, 2:00 pm, and 8:00 pm. the study will include three visits the patient to the study center: pretreatment / assessment 1, assessment 2 after 15 days of treatment, and the assessment 3 after 30 days of treatment. at each visit, data will be collected on the medical history, physical examination and vital signs, and evaluation of episodes of angina pectoris, as well as the laboratory evaluation of adverse events and the use of concomitant medications.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of chronic stable angina pectoris * female subjects post-menopausal or not pregnant and using of contraceptives * signature of informed consent document exclusion criteria: * pregnant women or nursing patients , women of childbearing age * hypersensitivity or intolerance to any component of the study drug * angina pectoris class iv, according to the canadian society of cardiology * clinical diagnosis of severe anemia , glaucoma, head trauma , increased intracranial pressure, cerebral hemorrhage, acute myocardial infarction, congestive heart failure, aortic valve disease * recent infarction (within the last 3 months) * recent history (within the last 6 months)of angioplasty * use of these medicines within 7 days screening : sildenafil citrate and other inhibitors of phosphodiesterase-5 , adrenergic substances * significant alteration of any laboratory test (\> 20% above or below the normal range ) * gastric or intestinal ulcer or intestinal * asthma or chronic rhinitis * any other condition which in the opinion of the investigator, shall exclude the study of the patient.

Keywords: chronic stable angina pectoris propatyl nitrate seattle angina questionnaire