Kornimate/medical-research-clean huggingface dataset:
relationship: interstitial cystitis & vulvodynia-part 2

Conditions: Vulvodynia

Summary: the etiology of pain in women with ic is often difficult to identify resulting in unnecessary medical and surgical treatments (e.g. hysterectomies). the vulva may actually be the site of some of the reported pain in women with ic, not the urethra or bladder. ic and vulvodynia can impact one's sexual functioning and diminish one's quality of life. unfortunately, vulvodynia is often unrecognized since it is not part of the usual urological assessment with ic patients. vulvodynia is characterized by persistent generalized or localized vulvar pain of varying degrees often characterized as "burning," suggestive of a neuropathic pain response.

in a mailed survey (part 1 of this study), 127 women with a documented diagnosis of ic agreed to be contacted for an in-office examination. the mailed survey was internally developed specifically for this project and included items related to demographics, adolescent and adult history related to genital pain and current health. the last section allowed the subject to include contact information if they would also like to participate in part 2 (additional questionnaires and examination) of the study. the study coordinator will review those surveys containing contact information and all women at least 18 years of age will be invited to the wish program (beaumont women's initiative for pelvic pain and sexual health) to be examined by a certified nurse practitioner (np) who will be blinded to their survey responses. questionnaires will be completed by the subject. these questionnaires relate to one's history, pain symptoms, quality of life, bladder symptoms and sexual function and will be completed prior to the examination. the np will perform all the clinical evaluations. a vaginal ph and wet mount slide will be done first. testing for vulvodynia will be done utilizing an algesiometer q-tip followed by neurometer® surface cpt testing for pain threshold (not tolerance) to quantify pain levels in the distribution of the pudendal nerve on the perineum and vulva will be done. the neurometer® current perception threshold (cpt) is a device for evaluating and measuring sensation it is a battery-operated stimulator which delivers painless electrical stimulation via surface electrodes at frequencies of 5 hz, 250 hz, and 2000 hz and at a current of 0.01 to 99mamps.

Eligibility criteria:
inclusion criteria * women with interstitial cystitis and vulvar pain who agreed to be contacted in part 1 (hic #2007-183) of this study. * age 18 or older * capable of giving informed consent * capable and willing to follow all study procedures exclusion criteria: * pregnant women· vaginitis (may be treated, then tested later) * vulvar disease (other than vulvodynia)-lichen planus, lichen sclerosis, neoplasia * the subject is deemed unsuitable for enrollment by the investigators based on their history or physical examination. * neuropathy

Keywords: vulvar pain vulvodynia interstitial cystitis
economic evaluation of baroreceptor stimulation for the treatment of resistant hypertension

Conditions: Hypertension

Summary: medico-economics assessment (cost-effectiveness) of the unilateral carotid barostimulation with barostim neotm compared to usual care in patients with resistant hypertension (multicenter randomized, probe trial), followed-up for 12 months, with a lifetime-long modeling.


Eligibility criteria:
main inclusion criteria: * 18-85 years old men or women * resistant hypertension on 4 medications incl. thiazide or thiazide-like diuretics at appropriate doses + spironolactone (unless spironolactone intolerance) * essential hypertension documented (bilan \< 2 years old) * egfr ≥ 30 ml/min/1,73 m2 * no carotid condition associated with a contra-indication for barostim neotm use main exclusion criteria: * patients with documented secondary hypertension, besides obstructive sleep apnea * symptomatic orthostatic hypotension * patient with prior syncope or myocardial infarction, unstable angina pectoris, or cerebrovascular within 3 months before inclusion * patient with type 1 diabetes mellitus * patient with permanent atrial fibrillation * patient with brachial circumference of ≥ 46cm * patient with bmi\>45kg/m2 * pregnancy, breastfeeding or planning a pregnancy within 2 years * neotm implantation anatomic contra-indications

Keywords: hypertension baroreceptor stimulation hypertension resistant
prenatal education about infant immunization pain management

Conditions: Immunization

Summary: there are numerous pain management strategies available for the management of infant immunization pain. the majority of infants, however do not benefit from these interventions, which causes them to suffer pain unnecessarily. this study will assess the impact of educating parents about pain management strategies on their knowledge and behaviour regarding pain management during routine 2-month infant immunization injections.

there is ample literature outlining effective pain management strategies for immunization including psychological, physical and pharmacological interventions; however their use in clinical practice has been limited. teaching parents about these strategies in an enriching setting such as prenatal education classes has the potential to increase utilization of these strategies, and empower parents to take on a more active role in the management of their infant's pain during routine immunization. educating parents about pain-management for infant immunization has not been previously investigated in this setting. the aim of this cluster-randomized controlled trial is to evaluate the effectiveness of an immunization pain-management education module added to the prenatal education program at mount sinai hospital on parental knowledge and behaviour regarding pain management during routine 2-month infant immunization injections.

Eligibility criteria:
inclusion criteria: * mothers attending weekend prenatal classes * delivery of a healthy newborn \> 35 weeks gestational age * available for followup for infant's 2-month immunization exclusion criteria: * mothers who do not plan to immunize their infants * infant with major birth defect or hospitalized at time of immunization * mothers who need to attend the prenatal class at a separate time when education not offered

Keywords: parent education pain management immunization infant
effect of mixed on-line hemodiafiltration on circulating markers of inflammation and vascular dysfunction

Conditions: Chronic Kidney Failure; Dialysis Related Complication

Summary: on line haemodiafiltration (ol-hdf) has been shown to improve intra-dialytic hemodynamics and cardiovascular outcomes. several potential candidates of these beneficial effects have been explored. the aim of this study was to investigate the impact of mixed ol-hdf (mol-hdf) on different circulating mediators of vascular dysfunction.

this is an open label placebo-controlled randomized clinical trial to assess the effect of mixed ol-hdf (mol-hdf) on different circulating mediators of vascular dysfunction. inclusion criteria: age \> 18 yrs, hemodialytic treatment from at least 6 months (3 times for week), blood flow rate (qb) ≥ 250 ml/min using arterovenous fistula (avf) or permanent central venous catheter (cvc), blood creatinine clearance \<5 ml/min, urine output\<500 ml/die. exclusion criteria: neoplastic diseases, chronic autoimmune diseases, lack of consent, solid organ or bone marrow transplantation. safety assessment: the use of mol-hdf has been approved by the european medicines agency as routine hemodepurative technique for end stage renal disease patients. patients were evaluated for adverse reaction at each dialysis section; investigators recorded intra and extra-dialytic adverse events. study treatment, dosage, and route of administration: enrolled patients have been randomized in 2 groups: 15 patients continued high flux bicarbonate hemodialysis (bhd), whereas 15 patients switched to mixed on-line hemodiafiltration (mol-hdf using fx 1000 cordiax, fresenius medical care, bad homburg, germany) for 9 months. efficacy assessments: main outcome variable: changes in rna content of circulating exosome/microvesicles (at 9 months) secondary outcomes: changes in circulating inflammatory markers (c-reactive protein, neutrophil gelatinase associated lipocalin, interleukin-6, ferritin) at 3-6 and 9 months. changes in rna content of circulating microvesicles (at 3 and 6 months) study duration: 9 months statistical methods: data have been analyzed according to an intention-to-treat approach. statistical analysis was performed using the unpaired student t -test, anova, or kruskal-wallis test when appropriate. a two-sided value of p=0.05 was considered significant.

Eligibility criteria:
inclusion criteria: * hemodialytic treatment from at least 6 months (3 times for week), blood flow rate during dialysis session (qb) ≥250 ml/min using arterovenous fistula (avf) or permanent central venous catheter (cvc), blood creatinine clearance \<5 ml/min, urine output \<500 ml/die. exclusion criteria: * neoplastic diseases, autoimmune diseases, solid organ or bone marrow transplantation
bioarray for the serological assessment of immunity against vaccine-preventable infections

Conditions: Immunization; Infection

Summary: recent observations in germany revealed above-average high proportions of refugees affected by infectious diseases of public health significance. scrutiny of the vaccination status showed sizeable presence of seronegative subjects, with conspicuously higher prevalence among children and adolescents, thus indicating urgent necessity of i) rapid identification of carriers of vaccine-preventable diseases and ii) adjustment of protection against such infections to european standards. rapid immune status check needs comprehensive diagnostic tool permitting simultaneous assessment of seropositivity. validation of such tools requires comparisons of the immune status of subjects with known vaccination history with that of migrants with incomplete or missing health and vaccination records.

the current massive inflow of refugees and migrants poses urgent necessity of i) rapid identification of carriers of communicable diseases and ii) adjustment of protection against vaccine-preventable infections to european standards. while universal vaccination is supposed to ensure the intended degree of protection, targeted vaccination on the basis of previous assessment of the immune status (seropositivity) was repeatedly shown to be a cost-efficient alternative. currently, the broad use of immune status assessment prior to targeted vaccination is impeded by the necessity to apply separate seropositivity detection assays for each individual condition. this drawback can be overcome by the introduction of a comprehensive diagnostic tool permitting simultaneous assessment of seropositivity for several vaccine-preventable infections. the objective of the present study consists in compilation of an array of sera from * subjects with known history of immunization against vaccine-preventable infections for which vaccines are routinely available (measles, mumps, rubella, varicella, tetanus, pertussis, poliomyelitis, diphtheria, meningococcal infection) and * new migrants/refugees without reliable vaccination records and undefined immune status to be subsequently used for the validation of a multi-pronged diagnostic tool for seropositivity detection

Eligibility criteria:
inclusion criteria: * age above 18 years * signed informed consent exclusion criteria: * acute infectious condition * glucocorticoid medication above 0.3 mg/kg prednisolone equivalent over the preceding 30 days * treatment with recognized t cell immunosuppressant or nucleoside analogues during the preceding 90 days
relationship between cetp deficiency and atherosclerosis in patients with hyperalphalipoproteinemia

Conditions: Low CETP Activity; CETP Deficiency; Hyperalphalipoproteinemia; Hyper-LDL-cholesterolemia; High Level of Remnant Cholesterol

Summary: the aim of this study is to determine whether high high density lipoprotein-cholesterol(hdl-c) level and low cholesteryl ester transfer protein(cetp) activity is atherogenic or not in subjects who received health checkups. we investigate the association between cetp activities and the severity of atherosclerosis assessed by intima-media thickness (imt) and compare the atherogenic change between in subjects with high hdl-c level, low hdl-c level, high cetp activities and low cetp activities by examining the morbidity rate of atherogenic diseases, the rate of ischemic electrocardiography(ecg) change, calc score of artery from chest x-ray, ankle brachial index/pulse wave velocity and various serum atherogenic markers. and we also examine the correlation between normal lipid profile and concentration, activity and function of surface lipoprotein in subjects with variety of lipoprotein levels, including patients with hyper-ldl-cholesterolemia, hyper-hdl-cholesterolemia with low or no cetp activity, patients with high level of remnant cholesterol or hyperlipoproteinemia of apolipoprotein(apo)b-48.


Eligibility criteria:
inclusion criteria: subjects who are at the age of 40 and above and undergo annual health check in omagari area including daisen city and yokote city and who provide written informed consent. exclusion criteria: 1. those who do not provide written informed consent. 2. those who are not able to take tests. 3. those who are regarded not adequate as subject of this study by their physicians.

Keywords: cetp, hdl, ldl, apob-100, apob-48, remnants
trial of ffp+hdmp+rituximab for ultra-high risk chronic lymphocytic leukemia

Conditions: Chronic Lymphocytic Leukemia

Summary: the purpose of this study is to investigate efficacy and safety of fresh frozen plasma(ffp), high dose methylprednisolone(hdmp) and rituximab for ultra-high risk chronic lymphocytic leukemia.

chronic lymphocytic leukemia remains incurable and particularly in ultra-high risk subgroup, and the prognosis of these patients is still dismal. this is a phase iii, multicenter perspective clinical trial of combination of fresh frozen plasma(ffp), high dose methylprednisolone(hdmp) and rituximab for ultra-high risk chronic lymphocytic leukemiathe. the main purpose of this study is to investigate efficacy and safety of this combinated regimen in subgroup of cll patients. all the enrolled patients will be followed during and after the treatment period up to one year. interim and final evaluation will be done after each cycle of treatment.

Eligibility criteria:
inclusion criteria: 1. aged 18-80 years old. 2. diagnosis of chronic lymphocytic leukemia. 3. active disease meeting at least one of the international workshop on chronic lymphocytic leukemia 2008 criteria for requiring treatment. 4. ultra-high risk cll(meets at least one of the following criteria) (1)ultra high-risk genetics (17p deletion and/or tp53 mutation) (2)short pfs(\<24 months)after intense immunochemotherapy treatment(i.e. fcr, fr, pcr, br etc) (3)fludarabine-refractory 5. understand and voluntarily sign an informed consent form, able to adhere to the study visit schedule and other protocol requirements exclusion criteria: 1. severe allergic constitution or asthma. 2. recent myocardial infarction or hypotension. 3. ecog performance status of ≤ 2 at study entry. 4. active hepatitis b(dna \>1×103/ml) 5. severe and uncontrolled diabetes mellitus. 6. severe and uncontrolled hypertension(bp\> 150/90 mmhg after treatment). 7. active and uncontrolled systematic infection which need treatment of antibiotics. 8. clinical symptoms of dysfunction of central nervous system. 9. unstable and severe gastrorrhagia and peptic ulcer. 10. major surgery within three weeks. 11. any potential drug abuse, medical, psychological or social conditions which may disturb this investigation and assessment. 12. in any conditions which investigator considered ineligible for this study

Keywords: chronic lymphocytic leukemia ultra-high risk fresh frozen plasma methylprednisolone rituximab
the effects of an exercise regimen following tmj arthrocentesis

Conditions: Temporomandibular Joint Disorders

Summary: the goal of this study is to evaluate the short- and long-term effects of a self-administered exercise program on pain levels, jaw movement range, and jaw function in patients with temporomandibular joint (tmj) disorders. the main question it aims to answer is: does adding a self-administered exercise program to arthrocentesis improve pain, mouth opening, and jaw function compared to arthrocentesis alone in patients with tmj disorders? participants with acute or chronic tmj pain lasting at least three months and limited mouth opening will undergo arthrocentesis, with one group also following an exercise regimen. outcomes will be assessed over a 6-month follow-up period.


Eligibility criteria:
inclusion criteria: * limited mouth opening (\<35mm) and joint pain complaints according to the dc/tmd examination form, * pain complaints for 3 months or longer, * able to understand turkish in spoken and written language, * patients who can read the written consent form and give signed consent will be included in the study. exclusion criteria: * those with serious neurological disorders, * those with autoimmune disorders involving muscles or joints, * those with a history of alcoholism, * patients diagnosed with malignancy, * patients who have previously undergone surgery or radiotherapy in the head and neck region, * those with other tmd diagnoses that do not cause restriction or pain in mouth opening, * those who have received other treatments for the neck or tmj regions in the last 3 months, * those with a history of surgical treatment for the temporomandibular joint, * those with a history of allergy to any of the agents used in the treatment process, * those who use drugs that affect the musculoskeletal system, and * pregnant patients will not be included in the study.

Keywords: temporomandibular joint disorders arthrocentesis temporomandibular joint exercise therapy
the benefits of individualized follow-up with a sport-health professional in the care of patients with chronic respiratory diseases

Conditions: Chronic Respiratory Disease

Summary: pulmonary rehabilitation is an integral part of care for patients with chronic respiratory diseases. it improves patients' physical capacities, quality of life and symptoms, at least in the short term. the hypothesis that patients receiving personalized support from a professional following pulmonary rehabilitation will maintain long-term benefits. this study concerns patients with a diagnosis of one or more chronic respiratory diseases. it is a multicenter, blinded, randomized controlled superiority trial in 2 parallel arms: * a group comparing follow-up and personalized support after a pulmonary rehabilitation program (experimental group) * a control group receiving only usual care

pulmonary rehabilitation is an integral part of care for patients with chronic respiratory diseases. it improves patients' physical capacities, quality of life and symptoms, at least in the short term. the hypothesis that patients receiving personalized support from a professional following pulmonary rehabilitation will maintain long-term benefits. this study concerns patients with a diagnosis of one or more chronic respiratory diseases. it is a multicenter, blinded, randomized controlled superiority trial in 2 parallel arms: * a group comparing follow-up and personalized support after a pulmonary rehabilitation program (experimental group) * a control group receiving only usual care each patient is followed up for 24 months with a visit every 6 months. a total of 352 subjects will be recruited

Eligibility criteria:
inclusion criteria: * diagnosis of one or more chronic respiratory diseases (asthma, chronic obstructive pulmonary disease, diffuse interstitial lung disease, bronchiectasis, obstructive sleep apnea syndrome, etc.). * participation in a respiratory pulmonary program * have given consent * patient of legal age * patient affiliated to social security exclusion criteria: * any medical contraindication to the practice of adapted physical activity in rehabilitation * patient refusal * patients under guardianship or curatorship * patients deprived of their liberty * minors * patients over 80 years of age at the time of inclusion.

Keywords: chronic respiratory disease pulmonary rehabilitation
fundus changes in the microphthalmy eyes

Conditions: Eye Diseases, Hereditary

Summary: the goal is to describe the fundamental aspects of fundoscopic eye in patients with microphthalmia

microphthalmos is a developmental ocular disorder defined as a small eyeball. the condition can be associated with abnormalities of anterior and posterior segments. the most common anterior characteristics include corneal opacities, angle-closure and a shallow anterior chamber and cataract. the main findings of posterior segment are uveal effusion, retinal folds, abnormalities of macular capillary vascularization, absence of foveal depression and peripheral retinoschisis. we performed on 3 patients with microphthalmos and their oct features of posterior segment.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of microphthalmia exclusion criteria: * eyes larger than 18mm

Keywords: retina fold fovea
transverse vs longitudinal incision in myomectomy

Conditions: Myoma;Uterus

Summary: the aim of the study is to compare between transverse and longitudinal uterine incision in abdominal myomectomy regarding intraoperative blood loss.


Eligibility criteria:
inclusion criteria: 1. inclusion criteria for myomectomy as; abnormal uterine, pressure related symptoms, infertility and recurrent pregnancy loss in patients between 18 and 45 years old 2. single myoma. 3. women with bmi between 18.5-29.9 kg/m2. exclusion criteria: 1. pregnancy. 2. patients with bleeding tendency 3. previous laparotomies. 4. patients with concomitant pelvic pathologies, such as ovarian cysts.