Kornimate/medical-research-clean huggingface dataset:
conversion rate of (tst) tuberculin skin test and quantiferon-tb gold in tube assay in health care workers

Conditions: Tuberculosis

Summary: the purpose of this study is to access conversion rate of tst (tuberculin skin test) and quantiferon-tb gold in tube assay in health care workers.


Eligibility criteria:
inclusion criteria: * age 20-75, men and women * participant who was enrolled in the study of latent tuberculosis in health care worker (irb no.4-2009-0187) * high risk or low risk health care worker who was performed tst or quantiferon-tb gold in tube assay before exclusion criteria: * age \< 20 * person who don't agree with enrollment * illiterate * person who is diagnosed as active tuberculosis now * person who has history of hypersensitivity on ppd (tuberculin purified protein derivative) * pregnant woman * person who is treated as active tuberculosis

Keywords: latent tuberculosis in health care workers
preparing for kidney transplant by attaining a healthy weight

Conditions: Kidney Transplant

Summary: the purpose of this study is to determine if an assigned physical fitness program will result in weight loss to prepare patients for kidney transplant.

the goal of this study is to prepare subjects for kidney transplant. patients who are in need of a kidney transplant but are unable to be place on the wait list due to weight will be enrolled in a six month workout program. the workout program will consist of counseling from a registered dietician, personal training from certified trainers and constant health monitoring.

Eligibility criteria:
inclusion criteria: * adult patients over 18 years of age and older but less than 65 * all patients who are currently listed as "inactive" on the university of chicago kidney transplant wait list * those with a body mass index of 40-44 * those with access to the internet * have transportation to the fitness center (formula fitness center at union station location) exclusion criteria: * those patients who are listed "inactive" on the wait-list due to co-morbid conditions other than obesity * those who are unwilling to attend fitness center appointments * those who do not have adequate transportation to the fitness center * those who do not have access to the internet * those who are not comfortable navigating and using the internet
evaluation of innovative 3d printed space maintainer versus conventional one

Conditions: Missing Teeth

Summary: the primary aim of this study is to introduce a new effective and efficient 3d printed design of an intra-oral space maintainer. the secondary aim of the study is to: evaluate the clinical performance of 3d printed space maintainer versus conventional metal band and loop over a period of 6 months regarding their functional , biological aspects and patient satisfaction.

and will be conducted as follows: * in-vivo evaluation of the clinical performance of 3d printed space maintainer versus metal band and loop concerning oral hygiene, retention and patient satisfaction. * a total of thirty healthy subjects will be selected from the pediatric dentistry and dental public health outpatient clinic, faculty of dentistry, ain shams university. they will be divided using simple randomization in two groups: group 1: children with 3d printed space maintainer (n=15) group 2: children with conventional band and loop(n=15)

Eligibility criteria:
inclusion criteria: * aged 6-9years' old * premature loss of primary molar or molars in one or more quadrant. * absence of abnormal dental conditions such as cross bite. * sound and healthy buccal and lingual surfaces of abutment teeth. exclusion criteria: * bad oral hygiene * medically compromised patients. * presence of periapical pathology radiographically. * carious buccal and lingual surfaces of abutment teeth.

Keywords: space maintainer 3d printing
the efficacy, safety, and tolerability of probiotics on the mood and cognition of depressed patients

Conditions: Major Depressive Disorder; Depression; Depressive Symptoms

Summary: this study will be an 8-week open-label pilot study examining subjective and objective changes in mood, anxiety, cognition, and sleep before and after the introduction of a probiotic supplement containing lactobacillus helveticus and bifidobacterium longum in 10 treatment-naïve participants diagnosed with major depressive disorder (mdd). in order to examine the full composition of the micro biome, the investigators will also be collecting and analyzing fecal samples as well as blood samples to examine changes in plasma levels of inflammatory markers, 5-ht, and tryptophan in order to look at possible underlying mechanisms of any changes seen.


Eligibility criteria:
inclusion criteria: 1. diagnosis of major depressive disorder (mdd) by mini international neuropsychiatric interview (mini) 2. current depressive episode with a madrs score of ≥ 20 3. males and females between ages 18 and 65 4. able to understand and comply with the requirements of the study 5. provision of written informed consent exclusion criteria: 1. use of any antidepressant drug 2. use of any antibiotic drug in the past 4 weeks (may be eligible to participate after a 1-month washout period) 3. use of any sleep medication in the past 4 weeks (may be eligible to participate after a 1-month washout period) 4. milk, yeast, or soy allergy 5. history of alcohol or substance abuse in the past 6 months 6. daily use of probiotic product in the past 2 weeks (may be eligible to participate after a 2-week washout period) 7. use of any type of laxative 8. consumption of products fortified in probiotics 9. severely suicidal 10. experiencing psychosis or bipolar episode 11. history of epilepsy or uncontrolled seizures
ketamine vs hydromorphone

Conditions: Laparoscopic Gastric Bypass; Obesity; Pain, Postoperative

Summary: this study will help to determine if investigators can minimize narcotic use in laparoscopic gastric bypass patients while maintaining adequate pain control. this will allow investigators to minimize the negative side effects of narcotics which is a goal in this population.

the study will be a head to head observational study of patients who have undergone gastric bypass surgery. the methods of intraoperative anesthesiology will be ketamine or narcotic. both are fda approved methods of delivering anesthesia. the amount of narcotics a patient receives is part of the medical record post-operatively will be followed from post-anesthesia care unit (pacu) through to discharge. the amount of narcotics needed to control the patient's pain (converted to morphine equivalent units) and pain scores (a hospital standard measure) will be collected for 48 hours for the study, or until discharge, whichever occurs sooner. the conversion to a morphine equivalent unit allows investigators to compare different narcotics the patient may receive in a more standardized way. the results will be analyzed and compared between the two groups.

Eligibility criteria:
inclusion criteria: * obese patient presenting for laparoscopic gastric bypass between 18 and 65 years of age exclusion criteria: * hypersensitivity, allergy, or contraindications to fentanyl, propofol, or ketamine.
induced sputum versus bronchoscopy in smear negative pulmonary tuberculosis

Conditions: Pulmonary Tuberculosis

Summary: this is a randomised study that compares different diagnostic approaches for diagnosing pulmonary tuberculosis in patients suspected of pulmonary tuberculosis in whom the three classic (non-induced) sputum samples didn't show tuberculous bacillus on direct examination. the investigators compare the sensibility of induced sputum technique with an endoscopic approach (ct-scan followed by bal and fluoroscopy-guided transbronchial biopsies and eventually sputum collection immediately after the bronchoscopy). people in high risk population for tuberculosis undergoing screening by chest x-ray or symptomatic patients will be admitted to the hospital if their chest x-ray shows a suspicion of active tuberculosis. according good clinical practice: (non-induced) sputum samples will be taken at admission and every following morning. if direct examination and pcr of the first three classic sputum samples are negative: patients will be randomised in two groups with a different diagnostic approach (induced sputum versus endoscopic approach) the aim of our study is to proof that a thoroughgoing endoscopic approach has a higher sensibility than an induced sputum in the diagnosis of pulmonary tuberculosis in patients with a high suspicion of active tuberculosis on the chest x-ray but with a negative direct examination and/or pcr on three consecutive normal sputum samples. the investigators will include 154 patients (based on a statistical analysis for a hypothesis that the endoscopic approach has a sensibility that's twice the sensibility of the induced sputum). * first arm: 2 consecutive induced sputum using an ultrasonic nebulizer. * second arm: ct thorax to evaluate the exact anatomic localisation of the disease followed by fluoroscopy-guided bronchoscopy for bal (bronchoalveolar lavage) and transbronchial biopsies. a sputum sample immediately after the endoscopy will be collected if possible.


Eligibility criteria:
inclusion criteria: * patient suspected of pulmonary tuberculosis with 3 consecutive (non-induced) sputum samples negative on direct exam and pcr. exclusion criteria: * age \< 18 * pregnancy * actual asthma exacerbation * participation to study refused by patient

Keywords: pulmonary tuberculosis negative sputum exam induced sputum endoscopy
vitamin d and inflammatory markers of cardiovascular disease in african americans with type 2 diabetes

Conditions: Vitamin D Deficiency; Diabetes

Summary: recent clinical trials in non diabetics showed that vitamin d supplementation markedly reduced serum levels of c-reactive protein (crp), interleukin-6, and tissue matrix metallo-proteinases. our study objective is to evaluate if administration of vitamin d in african americans with hypovitaminosis d and dm type 2 decreases serum levels of inflammatory/thrombotic markers such as crp: highly sensitive c reactive protein.

other questions in our study: in diabetic african american patients, 1. prevalence of vitamin d deficiency? 2. correlation/relationship between vitamin d levels, calcium level, parathyroid hormone (pth) and inflammatory markers setting: all visits will take place at the fantus diabetes clinic.

Eligibility criteria:
inclusion criteria: * african americans * dm type 2 exclusion criteria: * symptomatic vitamin d deficiency * hypocalcemia * hypercalcemia * malabsorption * liver disease * patients with creatinine \> 1.5. (ckd \>/= 3) * pregnancy

Keywords: inflammatory markers
comparison of genicular nerve block and intraarticular injection for postoperative pain in knee arthroscopy

Conditions: Postoperative Pain

Summary: this prospective double-blinded randomized study will be conducted to compare ultrasound-guided intra-articular injection and ultrasound-guided genicular nerve block for postoperative analgesia after knee arthroscopy.

arthroscopic knee surgery has become increasingly popular in modern orthopedics. post-operative knee pain management has become a challenge to provide early relief and pain-free postoperative care to the patient. pain management has become a priority for management as a daycare procedure. patients operated as a daycare procedure should have minimal postoperative pain which influences the timing of discharge. pain is due to multifactorial causes such as irritation of free nerve endings of the joint capsule, synovial tissue, anterior fat pad. effective pain relief allows the patients to obtain early knee mobilization and optimal rehabilitation and thus improves patient satisfaction. postoperative pain after knee arthroscopy is commonly moderate to severe and can affect the patient's activity level and satisfaction. in an effort to provide safe, effective, and long-lasting post-arthroscopy pain relief, many drug regimens were injected intra-articularly including local anesthetics alone or with additive drugs to prolong and improve the quality of postoperative analgesia. genicular nerve block (gnb) and ablation have been used for managing chronic pain from knee osteoarthritis with good success.

Eligibility criteria:
inclusion criteria: * scheduled for unilateral knee arthroscopy surgery (ligament reconstruction, cartilage procedures, and diagnostic arthroscopic procedures) * aged between 18 and 50 years * of both genders, * have asa physical status i and ii. exclusion criteria: * revision knee arthroscopy, * previous surgery or trauma to the knee, * drug allergy, * regular narcotic use, * renal \&/ or hepatic impairments, * neuromuscular diseases * and coagulopathy disorders.
impact of roux-en-y pouch reconstruction compared with conventional roux-en-y reconstruction on quality of life in patients undergoing total gastrectomy

Conditions: Gastric Tumor

Summary: the purpose of this study is to find out more about differences of the quality of life in patients undergoing roux-en-y pouch reconstruction and conventional roux-en-y reconstruction. to find a better reconstruction for patients who received total gastrectomy.

total gastrectomy has been indicated mainly for advanced gastric cancer located from the upper to middle third of the stomach or multiple gastric cancers.the most common method of creating a way for food is called a "roux-en-y", in which one part of the intestines is connected with the end of the esophagus (the swallowing tube) in the abdomen, and another connection is made between the intestines ' lower down. patients with total gastrectomy suffer from poor food intake, anemia, and poor digestion because of loss of gastric reservoir or a lack of normal hormonal secretion for digestion. it often is associated with a limitation of postoperative quality of life (qol). to improve postoperative nutritional status and qol, surgeons have tried to establish ideal reconstruction after total gastrectomy and the optimum procedure for reconstruction has been discussed. this study will compare the postoperative quality of life (qol) of gastric pouch reconstruction with the usual reconstruction to see if the pouch makes patients feel better.

Eligibility criteria:
inclusion criteria: * • pathologically confirmed gastric malignant tumor at fuscc (biopsy may be performed at other institutions but slides must be confirmed at shca, as is routine care at our institution) , and the patients be assessed must be carried out total gastrectomy by three specialists. * patients 20-75 years old * normal organ function, able to tolerate surgery, no clear contraindication for surgery * no evidence of metastases of adjacent organs * be able to provide follow-up over 2 years * no specific treatment for gastric cancer before surgery * in line with the declaration of helsinki and the requirements of the hospital ethics committee. * the subjects were able to understand and comply with the trial protocol, and signed informed consent. exclusion criteria: * • synchronous or metachronous (less than five years) and with other malignancies. * cirrhosis and portal hypertension * associated with blood diseases * serious heart/ lung and kidney dysfunction or with metabolic diseases such as diabetes, hyperthyroidism. * suffering from a serious neurological diseases or psychological diseases affecting the life

Keywords: gastric malignant tumor total gastrectomy reconstruction
the application of transcriptomics in the treatment of ulcerative colitis with ustekinumab

Conditions: Ulcerative Colitis

Summary: the investigators hope that the present study will highlight new transcriptomic prognostic markers of response to ustekinumab with the ultimate goal of individualizing treatment and making a more targeted selection of uc patients who will benefit from this biological agent.

introduction: optimizing treatment with biological agents is an ideal goal for patients with ulcerative colitis (uc). at present, there are insufficient prognostic markers of response to each biological agent, which makes it difficult to individualize treatment. recent data suggest that mucosal inflammation patterns and serum cytokine profiles differ between patients who respond and those who do not. these studies mainly focused on anti-tnfα agents and vedolizumab, while there are no corresponding data for ustekinumab, which is a monoclonal antibody to interleukins 12 and 23 and has recently been approved for the treatment of patients with uc. aim of the study: to highlight prognostic markers of response (clinical and endoscopic) to ustekinumab, in patients with uc, utilizing information from their transcriptome before starting treatment. methods: this is a prospective, single-center cohort study that will evaluate transcriptomic markers of response to ustekinumab in patients with active uc. the diagnosis of the disease will be based on the established clinical, endoscopic and histological criteria. the patients' recruitment will begin in april 2022, while their consent will be required. the duration of follow-up of patients will be at least 6 months from the start of biological treatment. patients will undergo endoscopy (sigmoidoscopy or total colonoscopy) with a biopsy of the orthosigmoid before the start of biological treatment and a repeat endoscopy 6 months later. the rna profile of the patients will be recorded after isolation of the total rna from colon biopsies. then, using biostatistics, the transcriptomic profiles of patients who responded to ustekinumab and those who did not respond to 6 months of treatment, will be compared.

Eligibility criteria:
inclusion criteria: * active uc in accordance with applicable diagnostic criteria \[25\] • * aged 18 or above exclusion criteria: * prior surgical history for uc * toxic megacolon * infectious complications (cl. difficile, cmv infection) * patients who received any approved biologic agent (e.g. infliximab, adalimumab, vedolizumab, golimumab) within the previous 8 weeks or any investigational biologic or other agent in the last 35 days
a comfort survey of open-angle glaucoma or ocular hypertension patients treated with 2 drugs

Conditions: Open-angle Glaucoma; Ocular Hypertension

Summary: the objective of the study was to evaluate whether timolol hemihydrate is more comfortable upon instillation than timolol maleate in sorbate. this was an observational study. subjects with open-angle glaucoma or ocular hypertension were asked to complete a survey regarding their normal treatment. no treatment was prescribed.


Eligibility criteria:
inclusion criteria: * willing to comply with investigator's and protocol's instructions * patients signature on the informed consent document * open-angle glaucoma or ocular hypertension * currently prescribed timolol hemihydrate (once a day (qd) or twice a day (bid))or timolol maleate in sorbate qd as monotherapy or as a part of 2-drug therapy in at least one eye exclusion criteria: * inability to understand the trial procedures * inability to give informed consent * inability to understand, read, or write english * best corrected visual acuity of 20/200 or worse in each eye * current moderate to severe infectious or inflammatory condition of the eye or eyelids including * current moderate to severe dry eye syndrome * current chronic use of ocular corticosteroids, ocular surgery or intraocular laser surgery to either eye in the prior 3 months * treated with 3 or more glaucoma medicines in both eye
impact of escitalopram on sperm dna fragmentation

Conditions: Sperm DNA Fragmentation; Infertility, Male

Summary: double-blind placebo-controlled randomized trial of daily escitalopram for 6 weeks in healthy men with normal semen analyses and no psychiatric history of depression, bipolar, mania or suicidal ideation. hormone profiles, semen analysis, sperm dna fragmentation, and sexual function will be measured at baseline, after 6 weeks of therapy, and 4 weeks after discontinuation of therapy (10 weeks into study).

ssri medications, specifically escitalopram is a very commonly prescribed medication among men of reproductive age. significant evidence exists that they may be harmful for paternal fertility potential in both animal and human studies. however, high quality data is lacking, particularly among commonly used ssri's such as escitalopram. as such, it is important to properly evaluate the potential effect of escitalopram in a randomized placebo controlled fashion. results will be important in guiding urologists, psychiatrists and family practitioners regarding discussion surrounding ssri use in their patients interested in fertility.

Eligibility criteria:
inclusion criteria: * normal semen analyses, or semen analyses with at least 5 million sperm * normal tunel value (\<7%) * willing to engage in at least weekly sexual activity, with a partner or alone for the duration of the 10-week study exclusion criteria: * azoospermia or severe oligospermia (\<5million sperm per semen analysis) * presently attempting to conceive pregnancy * sexual dysfunction preventing ability to provide semen analysis throughout study or engage in weekly sexual activity * current psychiatric disorder including: bipolar, mania, depression, generalized anxiety, social phobia, panic attacks, obsessive compulsive disorder, and schizophrenia. * family history of bipolar disorder, or suicide (including 2nd degree relatives) * present use of psychotropic agents (prescription or herbal) or anticonvulsants * use of sleeping pills * alcohol consumption greater that 2oz/day * use of illicit drugs * inability to read, follow instructions or complete questionnaires in english. * use of hormonal medications in past 3 months (androgens, androgen blockade, anabolic steroids, estrogens, herbal) * use of medications to enhance sexual function * history of chemotherapy or pelvic radiation * use of monoamine oxidase inhibitors (maoi's) or tricyclic antidepressants (tcas) within 14 days * liver disease
korean red ginseng rg3 extract on arterial stiffness and blood pressure

Conditions: Arterial Stiffness, Blood Pressure

Summary: the purpose of the study is to evaluate the acute effect of a standardized extract of krg (rg3-krg) consisting of 30% total ginsenosides, including 10% rg3 ginsenoside on arterial stiffness and blood pressure, as measured by the following parameters: aortic augmentation index, peripheral blood pressure, central blood pressure


Eligibility criteria:
inclusion criteria: * healthy * age 18-70 years * bmi \< 30 kg/m2 * brachial systolic blood pressure \< 140 mmhg * brachial diastolic blood pressure \< 90 mmhg main exclusion criteria: * bmi \>30kg/m2 * hypertensive (brachial systolic bp ≥140mmhg and/or diastolic bp ≥90mmhg) * pregnancy

Keywords: ginseng clinical trial vascular ginsenosides blood pressure