Kornimate/medical-research-clean huggingface dataset:
loss of parental workforce in paediatric fractures

Conditions: Pediatric Fractures; Lower Extremity Fractures; Upper Extremity Fractures

Summary: childhood fractures are frequently encountered in orthopaedic practice. 40-64% of boys and 25-40% of girls have at least one fracture by the age of 16. children, who are more fragile than adults, usually require additional care support during the treatment process. labour force statistics have determined that one third of the loss of labour force occurs after musculoskeletal injuries. when the literature is examined, there are many studies investigating loss of labour force after fractures. it was found that 20% of the patients never returned to work after distal radius fracture and the average loss of labour force was 9.2 weeks. in another study, while the return to work period was 60 days in minor hand injuries, it was reported that the return to work could increase to 360 days in major hand injuries. in another study, the average return to work time in patients aged \>50 years with fragility fractures was found to be 20.5 days. the rate of return to work after traumatic spinal fracture was found to be only 38.1%. in daily practice, the investigators observe that parents frequently do not go to work for child care after child fractures. however, there is no similar study investigating this loss of labour force after pediatric fractures in the literature. in this study, the investigators aimed to investigate the loss of parental labour force (lwl) in conservatively followed pediatric fractures


Eligibility criteria:
inclusion criteria: * patients \<18 years of age who underwent plaster splinting for any extremity fracture exclusion criteria: * parents of patients aged \>18 years * parents of patients undergoing surgical treatment * parents of patients whose initial diagnosis or follow-up was performed at an external centre * patients with one parent not working (patients with one working parent will be excluded) * parents of patients who did not want to participate in the study

Keywords: pediatric fracture parental workforce loss of workforce
polyetherketoneketone and metal framework for management of maxillectomy cases: across over study

Conditions: Patient Satisfaction

Summary: prosthetic rehabilitation of acquired maxillary defects represents a challenging mission for both the prosthodontist and psychologically traumatized patients. these defects may be due to trauma, pathological conditions, or surgical resection of oral tumors. the resulting main problem is oronasal communication leading to impairment in mastication, swallowing, speech, and facial esthetics

maxillary obturator prostheses are usually fabricated from polymethyl methacrylate (pmma) if the patient is completely edentulous, or from pmma and a cast frame-work if partially edentulous. as the size of the surgical resection increases, the weight of the prosthesis also increases. traditionally, the weight of the prosthesis has been minimized through the use of hollow bulb obturators and change of manufacturing material. polyetherketoneketone (pekk) has been widely tested in a number of dental applications, such as pekk dental implants, pekk obturators, and peek rpd frameworks. pekk has a relatively low young's modulus of 3 to 4 gpa, which is close to that of human bones, and its tensile properties are similar to those of bone, enamel, and dentin. these properties make it a suitable material for fixed and removable prostheses.(6-8) pekk is a lightweight material with excellent biocompatibility as it can be used in combination with computer-aided design/computer-assisted manufacturing (cad/cam) in fabrication of maxillofacial prostheses.(9) so the aim of this study will be, evaluation of patient satisfaction and oral healthy related quality of life of pekk and metal framework for management of maxillectomy cases. the null hypothesis is that, there would be no significant difference between both frameworks.

Eligibility criteria:
inclusion criteria: the patient will be selected according to the following criteria: * patient with unilateral total maxillectomy. * patients will have sufficient number of remaining teeth. * free from any signs of inflammation in defect area. * patient 3 years after receiving radiation. * the defect size is small or large. * patient with susceptibility of recurrence. exclusion criteria: * patient is still receiving radiation. * defect result from trauma.

Keywords: polyetherketoneketone, metal, obturator
a study investigating lu ag06474 in healthy young participants

Conditions: Healthy Participants

Summary: the purpose of this study is to investigate the safety of multiple oral doses of lu ag06474, how well the doses are tolerated, and what the body does to the drug after administering it to healthy young participants. this study also aims to compare how the body absorbs and uses lu ag06474 when it is given in capsule form versus when it is given as an oral solution.

the study has 2 parts: part a and part b. part a consists of up to 7 sequential cohorts (cohorts a1 to a7), with 8 participants per cohort randomized to receive multiple doses of either lu ag06474 or placebo: 6 will receive lu ag06474 oral solution and 2 will receive placebo. part b consists of 1 cohort (cohort b1), with 12 participants: all participants will receive 2 single doses of lu ag06474 (one as an oral solution and one in capsule form), taken 3 days apart.

Eligibility criteria:
inclusion criteria: * the participant has a body mass index (bmi) ≥18.5 and ≤30 kilograms per meter squared (kg/m\^2) at the screening visit and at the baseline visit. * the participant has a resting supine pulse ≥50 and ≤100 beats per minute (bpm) at the screening visit and at the baseline visit. for physically/athletically well-trained participants, the lower limit is ≥45 bpm. * the participant has a resting supine systolic blood pressure ≥91 and ≤140 millimeters of mercury (mmhg) and a resting supine diastolic blood pressure ≥51 and ≤85 mmhg at the screening visit and at the baseline visit. exclusion criteria: * the participant has previously been dosed with lu ag06474. * the participant has participated in a clinical trial \<30 days prior to the screening visit. * the participant has taken any investigational medicinal product ≥30 days or \<5 half-lives of that product, whichever is longer, prior to the first dose of imp.
retrospective data analysis in crohn's disease

Conditions: Crohn's Disease

Summary: the purpose of this study is to identify prognostic parameters about efficacy of mesalazine in recently diagnosed patients with morbus crohn by retrospective data collection.


Eligibility criteria:
inclusion criteria: * therapeutic need according to spc * written informed consent
a comparison of mcgrath mac versus c-mac videolaryngoscopes in morbidly obese patients

Conditions: Difficult Intubation; Morbid Obesity; Videolaryngoscopy

Summary: along with the technological advances in medicine, videolaryngoscope is the most commonly preferred technique for intubation of expected difficult airway management such as morbidly obese patients. in this prospective controlled clinical study, the purpose is to compare c-mac videolaryngoscope and mcgrath mac videolaryngoscope in respect to duration of intubation, haemodynamic response, and complications related intubation of morbidly obese patients undergoing bariatric surgery.

it is very important for anesthesiologists to evaluate and make the airway safe in order to start and continue surgical operations. endotracheal intubation has many important reasons such as ensuring airway control safely during surgical procedure, increasing the depth of anesthesia, need interventions for surgical or anesthetic complications, reduction of dead space, reduction of respiratory effort and prevention of aspiration risk. mask ventilation and tracheal intubation in morbidly obese patients can be difficult with the anatomical changes caused by obesity. reduced functional residual capacity in morbidly obese patients makes it difficult to maintain peripheral oxygen saturation at normal limits. videolaryngoscope, developed in recent years and beginning to take place in the algorithms, facilitate difficult airway management and hence intubation. the use of videolaryngoscope in patients with difficult intubation such as morbid obesity, has been frequently reported in the literature. mcgrath videolaryngoscope has a high-resolution video camera, a length-adjustable angle blade, and a light source at the tip of the blade. at the same time, the c-mac videolaryngoscope is another advanced videolaryngoscope with a better quality video and camera system and improves the performance of videolaryngoscope with some technological changes. in this prospective controlled clinical study, the purpose is to compare c-mac videolaryngoscope and mcgrath mac videolaryngoscope in respect to duration of intubation, haemodynamic response, and adverse events associated with intubation of morbidly obese patients undergoing bariatric surgery.

Eligibility criteria:
inclusion criteria: * american society of anesthesiology score iii, * 18-65 years, * bmi\> 40 exclusion criteria: * american society of anesthesiology iv, * under 18 years, * over 65 years, * under bmi\<40 * obstetric patients, * uncontrolled cerebrovascular disease, * patients who refused written informed consent forms

Keywords: morbidly obese difficult airway management videolaryngoscopy
opinions of company representatives about neuromodulation

Conditions: Neuromodulation; Pain; Survey

Summary: the goal of this online survey is to gain further insight in the goals, expectations and definition of success for neuromodulation for pain, according to neuromodulation company representatives.


Eligibility criteria:
inclusion criteria: - male and female adults who are involved in the management of chronic pain and more specifically in neuromodulation for pain as company representatives will be eligible to complete the survey. exclusion criteria: - not a company representative.
biparametric mri in prostate cancer screening: a noninferior randomized controlled study

Conditions: Prostate Cancer

Summary: this is a single centre non-inferiority randomized controlled trial in comparison of the bpmri between the traditional pathway in prostate cancer screening


Eligibility criteria:
inclusion criteria: 1. age between 18 and 80 years old 2. life-expectancy at least 10 years 3. fully understand the clinical trial protocol and sign the informed consent; exclusion criteria: 1. already diagnosis with prostate cancer; 2. cannot tolerate prostate biopsy or has contraindication to biopsy; 3. cannot tolerate prostate biopsy or has contraindication to mri examination; 4. undergo biopsy within 1 year 5. patients judged by the investigator to be unsuitable to participate in the clinical trial;

Keywords: prostate cancer screen bpmri psa
a study of vorinostat and tamoxifen in newly diagnosed breast cancer

Conditions: Stage I Breast Cancer; Stage II Breast Cancer; Stage III Breast Cancer; Invasive Breast Cancer

Summary: this research study is designed to look at the effects of the combination of vorinostat (suberoylanilide hydroxamic acid or zolinza) and tamoxifen on breast cancer tissue. the investigators will do this by comparing tissues from the original breast biopsy to tissues obtained after taking vorinostat and tamoxifen for 2 weeks.

key eligibility criteria include: * newly diagnosed invasive breast cancer awaiting surgery or neoadjuvant (preoperative) treatment * no use of hormone contraceptives or replacement therapy within 30 days prior to the diagnostic breast cancer biopsy (unless willing to have an additional biopsy prior to starting the study) * no prior or current use of any therapy to treat the current breast cancer.

Eligibility criteria:
inclusion criteria: * stage i-iii invasive breast cancer * awaiting surgery or neoadjuvant treatment * ecog performance status 0, 1 or 2 * adequate organ function * prior use of hormone contraception or replacement therapy must have been discontinued at least 30 days prior to diagnostic biopsy (unless participant is willing to undergo an additional biopsy for the study) exclusion criteria: * prior or current treatment of any kind for the current breast cancer * current use of any other investigational drugs * uncontrolled or active infection, congestive heart failure, cardiac arrythmia, or psychiatric illness

Keywords: preoperative neoadjuvant
the metabolic road to diastolic heart failure: diastolic heart failure study

Conditions: Diastolic Heart Failure

Summary: the main objective is to replicate the validation of omics biomarkers of left ventricular diastolic dysfunction in patients with metabolic syndrome. the aim was to recruit overall 750 patients in europe (100 for france). currently, 625 patients were enrolled in europe and 47 in france.


Eligibility criteria:
inclusion criteria: * patients 18 years of age or older * signs or symptoms of hf * able and willing to provide freely given written informed consent including analysis of genomics exclusion criteria: * patients with acute myocardial infarction * recent trauma or surgery (\< 3 months) * hemodynamically significant valvular disease * serious cerebrovascular disease or stroke in the last 3 months * chronic dialysis * chronic liver disease * chronic infectious (bacterial or viral) disease * any malignant concomitant diseases or a malignant disease in the last 5 years * systemic inflammatory diseases, such as autoimmune diseases, connective tissue diseases or collagenoses * pregnant women
the expert system voicediab in children with diabetes

Conditions: Type 1 Diabetes Mellitus With Hyperglycemia; Type 1 Diabetes Mellitus With Hypoglycaemia

Summary: the purpose of this study to conduct the preliminary investigation on the efficacy and safety in terms of postprandial glucose value and the rates of hypoglycaemia when expert voicediab system supports patient's decision on prandial insulin programming in insulin pump therapy.

in children with type 1 diabetes glucose deterioration occurred every day and night leading into low satisfaction with treatment. unstable glycemic profile resulting in high glycemic variability depends on the adjustment of insulin dosing to the current needs of the organism. the calculation of prandial insulin dosing is a complex process which involves such factors as preprandial blood glucose level, the amount of food taken, the glycemic index of carbohydrates, the insulin/carbohydrate exchange ratio, the active insulin level following the previous bolus. currently, in patients treated with continuous subcutaneous insulin infusion (csii) insulin pumps are equipped with bolus calculators which help to calculate prandial insulin dosing and thus contribute to improve post-prandial blood glucose levels. the aim of the study was to determine whether the patient's support expert voicediab system have stabilised diurnal glucose profile in children with type 1 diabetes treated with insulin pumps.

Eligibility criteria:
inclusion criteria: * diagnosed type 1 diabetes at least 12 month prior screening visit * current treatment with basal-bolus regime and insulin pump for at least 12 weeks prior screening visit. * hbac \< 11% * ability and willingness to adhere to the protocol including self-management and dealing with mobile device. exclusion criteria: * multiply daily injection modality, * treatment with regular insulin, * use of any anti-diabetic agent,

Keywords: bolus calculator insulin pump basal-bolus insulin therapy
genetics of prostate cancer in young patients

Conditions: Prostate Carcinoma

Summary: the aim of the study is to identify genetic variants in genes responsible or potentially responsible for the etiology of prostate cancer in a population of patients with early onset of the malignancy.

the data collected from the study will provide a preliminary picture of the prevalence and type of germline pathological variants in the context of early-onset prostate cancer in the italian population. in addition, alterations in dna repair genes other than brca1-2 and atm, including any genes yet undescribed as causative or predisposing, have yet to be explored in detail: in many cases the significance of variants is not well defined in terms of pathogenicity, prognostic value, and predictive indicator of response to different treatments. therefore, an extensive mutational analysis-even if performed on a limited number of patients-can generate a large number of variants for evaluation, bringing knowledge about the relationship between these variants and the onset of malignancy the information obtained, although merely exploratory, may indicate the desirability of conducting systematic genetic investigations in this particular patient population in the future, especially in view of the new therapeutic strategies available such as immunotherapy or parp inhibitors

Eligibility criteria:
inclusion criteria: * patients with histologic or cytologic diagnosis of prostate cancer * age ≥18 years and ≤55 years at first diagnosis of prostate carcinoma * availability of clinical and instrumental data related to prostate cancer * patients who knowingly express willingness to participate in the study after signing written informed consent exclusion criteria: * none
the effect of computerized alcohol screening and brief intervention (casi) on alcohol consumption in adolescent patients in the emergency department

Conditions: Alcohol Consumption

Summary: the purpose of this research is to examine the effectiveness of the computerized alcohol screening and brief intervention (casi) in adolescent patients in the emergency department at the uc irvine medical center. this research study will evaluate the effectiveness of the brief intervention compared to standard of care (no intervention). brief interventions have a high potential impact in ed. computerized alcohol screening and brief intervention (casi) is a fast and easy to use tool for patients and healthcare providers. casi provides the alcohol use disorders identification test (audit-c)4, from the world health organization and crafft3, followed by a brief intervention and customized alcohol intake recommendations for the patient. this study will also determine the effectiveness of the brief intervention in reducing alcohol use/abuse in adolescents between 12-17 years of age. the overall goal of this study is to identify at risk alcohol use/abuse in adolescents and provide an intervention at an early stage. the current data to support alcohol and screening and brief intervention in adolescents is limited. the researchers hope that this research study will add to the overall body of knowledge in support of using the emergency department as a tool in public health, as it relates to the individual patients morbidity and mortality (pancreatitis, cirrhosis) and to the societal costs of alcohol use (lost days of work, motor vehicle collisions).


Eligibility criteria:
inclusion criteria: - ages 12-17 exclusion criteria: - intoxicated
clinical evaluation of the glyde dressing for post-surgical incision care

Conditions: Post Surgical Incisions From Abdominoplasty Procedures

Summary: this study will evaluate a new dressing to be used for post-incision care for abdominoplasty patients. the hypothesis is that this dressing will minimize scar formation.

this study will evaluate a new dressing in up to 30 patients who have undergone an abdominoplasty procedure. they will wear the dressing through 8 weeks post surgery and the scar will be evaluated at 3 months post surgery.

Eligibility criteria:
inclusion criteria: * subjects who have undergone an abdominoplasty 1 week prior to study participation exclusion criteria: * subjects with a history of collagen vascular disease or scleroderma * subjects with known adverse reactions to steri-strips, medical tapes or adhesives

Keywords: incision abdominoplasty
clinical significance of appendicoliths in elderly patients over 80 years old undergoing emergency appendectomy

Conditions: Appendicoliths in Elderly Patients

Summary: acute appendicitis with an appendicolith is one of the most common abdominal emergencies in elderly patients and is more likely to progress to gangrene and perforation. this study aimed to analyze the clinical data of patients over 80 years old who underwent emergency appendectomy for acute appendicitis, to explore the clinical significance of appendicoliths, and to improve treatment strategies.


Eligibility criteria:
inclusion criteria: * patients who aged 80 years or older, who received conservative treatment for less than 24 hours before surgery, who had no peri-appendiceal abscess larger than 2 cm in diameter on ct scan, who underwent emergency appendectomy, and who had postoperative pathological confirmation of acute appendicitis. exclusion criteria: * patients younger than 80 years, those with malignancies, and those with incomplete clinical or pathological records were excluded from the study.
baby smart (study of massage therapy, sleep and neurodevelopment)

Conditions: Sleep; Neurodevelopmental Disorders

Summary: it is well known that sleep is essential for brain development and learning. infants require extensive sleep for development of the hippocampus, pons, brainstem, and midbrain and for optimizing physical growth. it is also essential for brain plasticity; the genetically determined ability of the infant brain to change its structure and function in response to the environment. studies in young animals have shown that sleep deprivation leads to increased programmed cell death, smaller brain size, and loss of brain plasticity, all of which have negative long-term impact on behaviour and learning ability. infant massage, a form of systematic tactile stimulation by human hands, improves sleep hygiene. very little is known about how massage influences early brain development but it is certainly linked to the theory of environmental enrichment, which has been well established in animal models. the aim of this project is to optimise the infant's sensory experience through a multi-sensory enrichment programme, including massage (a massage utilising a scented lotion before sleep each day), to encourage more structured sleep and ultimately show improved developmental and cognitive outcomes.

see study protocol attached.

Eligibility criteria:
inclusion criteria: 1. infants born \> 37 weeks gestation 2. single births 3. not requiring admission to the neonatal unit 4. healthy infants without suspected congenital or metabolic anomalies exclusion criteria: 1. infants born \< 37 weeks gestation 2. multiple births 3. severe metabolic or genetic anomaly that would require ongoing specialist care in the infancy period.

Keywords: infant sleep baby massage neurodevelopmental disorders