Kornimate/medical-research-clean huggingface dataset:
should ranges of vitamin d be redefined to prevent or treat viral infections?

Conditions: COVID; Vitamin D Deficiency

Summary: blood vitamin d levels may be associated with severity of viral infections. to find out if there is a statistically significant relation between blood 25-hydroxy vitamin d (25(oh)d) levels and disease severity, patients with covid-19 viral infection were investigated.

purpose: vitamin d a steroid hormone has profound effects on human immunity. active vitamin d, 1,25(oh)2d acts as an immune system modulator, preventing excessive expression of inflammatory cytokines and increasing the 'oxidative burst' potential of macrophages. epidemiological data has linked vitamin d deficiency to increased susceptibility to acute viral respiratory infections. there is evidence that some patients with severe covid-19 experience a cytokine storm with production of large quantities of interleukins, specifically il-1 and il-6. moreover it was hipotiesied that the sufficient vitamin d levels may help to decrease il-6 levels like tocizulamab which is a potent blocking agent of the il-6 receptor. in this observational study, possible relation between the disease and vitamin d levels were investigated in covi̇d-19 patients. material and methods: to find out vitamin d levels and it's relation with the disease severity serum 25-hydroxy-vitamin d levels will be measured in nearly 1100 confirmed covi̇d-19 patients. same patients will also be evaluated for vital signs, laboratory and pulmoner ct findings. demographic and medical data will also be collected. statically significant positive or negative results and the comparison of these findings will be presented. presenting blood vitamin- d levels and it's possible assosiation with disease severity may inspire new perspectives for future trials spesifically focusing vitamin d levels.

Eligibility criteria:
to find out vitamin d levels and it's relation with the disease severity serum 25-hydroxy-vitamin d levels, 1100 confirmed covid-19 patients with available laboratory findings were included. exlucion criterias: using immunsuppresan medical treatment. using vitamin d or replacement history of vitamin d in last 3 months. patients with malnutrition, immun deficiency, chronic infections, chronic other diseases such as rheumatoid arthritis, ankylosing spondilitis, lupus, hemplegia, paraplegia etc.

Keywords: covid-19, infection, vitamin d, prevention
assess screening for diabetic retinopathy using retinal camera in family medicine clinic

Conditions: Diabetes Mellitus

Summary: the long-term goal for this study is to improve compliance of screening for diabetic retinopathy among subjects with diabetes. researchers are also doing this research to determine the ability of appropriately trained family physicians to screen for and identify diabetic retinopathy using a retinal camera in addition to determining an overall patient perspective of the convenience and cost-effectiveness of retinal imaging within a primary care setting.


Eligibility criteria:
inclusion criteria: * patient ≥ 18 years of age * diabetes mellitus type i or ii * patient is willing and able to provide informed written consent exclusion criteria: • known diabetic retinopathy
beta blockers in acute ischemic stroke

Conditions: Stroke

Summary: the objective of this trial is to assess the safety and efficacy of neuro- and cardioprotective effects of propranolol in acute ischemic stroke. furthermore, exploratory analyses of cardiologic-electrophysiologic and immunologic parameters will be performed.

the main objective of this trial is to assess the efficacy and safety of propranolol in middle cerebral artery stroke patients. the primary hypothesis is as follows: early administration of propranolol reduces the frequency of cardiovascular and/or neurological complications including vascular death in the first 30 days after acute ischemic stroke. secondary hypotheses are as follows: early administration of propranolol improves neurological and functional outcome of patients with acute ischemic stroke. early administration of propranolol reduces post-stroke immunodepression and therefore lowers the rate of pneumonia after acute ischemic stroke, without increasing the frequency of auto-aggressive, cns antigen-specific t cells. early administration of propranolol influences alterations in cardiologic, electrophysiologic phenomenons as a reaction to autonomic dysregulation after acute ischemic stroke. early administration of propranolol reduces growth of infarct as determined by mri examinations in the first 6 days.

Eligibility criteria:
inclusion criteria: * symptom onset within 18 hours * acute ischemic mca-territory stroke * patients with suspected stroke in mca-territory and a) nihss \> 3 or b) imaging evidence of mca-infarction exclusion criteria: * patients already receiving beta-blockers * anti-arrhythmic, antiinfectious, antiinflammatory or immunosuppressive therapy * patients with a major heart disease, hypotension, bradycardia or any contraindication to the use of propranolol

Keywords: stroke
health outcomes via positive engagement in schizophrenia

Conditions: Schizophrenia Spectrum Disorders

Summary: this is an observational study where digital, clinical and health utilization data are collected from individuals with schizophrenia spectrum disorders who have been recently discharged from a psychiatric hospitalization. the data will be used towards building a model/algorithm capable of monitoring mental health and predicting adverse clinical events, such as relapse and re-admissions.

in this research, participants will attend 6-weekly follow-up research visits (weeks 0, 6, 12, 18, 24) over 24 weeks where clinical symptoms, cognition, functioning and well-being will be assessed. passive digital data from smartphones and wrist wearable devices (e.g. sleep patterns, heart rate, location variance and entropy, phone usage frequency and duration, finger taps, ambient light, and physical activity) will be collected continuously during the 24 weeks. audio recorded follow-up phone calls will be made to participants who consented to the optional audio recorded component at weeks 3, 9, 15, 21. this study will also carry out an administrative follow-up at week 24/termination and week 52 to obtain healthcare utilization information (e.g. scheduled or unscheduled appointments, readmission, etc) since study enrollment. study findings will shed light on the relationship between digital biomarkers with clinical status and health utilization outcomes, as well as explore the feasibility and acceptability of digital sensors.

Eligibility criteria:
inclusion criteria: * adult male or female aged 21 to 65 years (inclusive) at time of informed consent * has capacity to give informed consent * able to understand and comply with instructions in english * diagnosis of schizophrenia spectrum disorders assessed using the structured clinical interview for dsm disorders (scid) * discharged patients from imh (within 8 weeks post-discharge from imh) exclusion criteria: * female who is currently pregnant or planning a pregnancy within 6 months * has any other clinically significant medical condition or circumstance that, in the opinion of the investigator, could affect participant safety, preclude evaluation of response, interfere with the ability to comply with study procedures, or prohibit completion of the study * has visual or physical motor impairment that could interfere with study tasks

Keywords: schizophrenia digital phenotyping relapse
evaluation of resection techniques for pancreatic tumors

Conditions: Surgery; Liver Tumor; Pancreas Tumor

Summary: the objective of this study is to compare open and minimally invasive pancreatic and liver resection techniques and analyze the different outcome variables from the clinical standpoint. the plan is to investigate patient survival, length of stay, complication rates, operative time, transfusion rate, 30 and 90-day readmission rate, and hospital charges.

the plan is to conduct a retrospective chart review of patients who have undergone pancreatic and liver resection by using meditech and epic. a non-identified database will be created after retrospectively reviewing each patient case involving pancreatic or liver resection at mdmc. the study period will start in january 2006 until december 2020. variables will include demographics, clinical disease diagnoses, and operative parameters as well as indirect charges from the hospitalizations.

Eligibility criteria:
inclusion criteria: * patients that have undergone pancreatic or liver resection surgeries from january 2006 until december 2020 at methodist dallas medical center (mdmc) * patients 18 years old or older exclusion criteria: * patients that have not undergone pancreatic resection surgeries * patients under 18 years of age
treatment strategies and survival outcome for non-small cell lung cancer with oncogenic mutation

Conditions: Non Small Cell Lung Cancer; EGFR Gene Mutation; ALK Gene Mutation; ROS1 Gene Mutation; MET Gene Mutation

Summary: the purpose of this study is to assess the treatment strategies and survival outcome for non-small cell lung cancer with oncogenic mutation.

the purpose of this study is to assess the treatment strategies and survival outcome for non-small cell lung cancer with oncogenic mutation. our study was set up with several group with egfr mutant, alk fusion, ros1 fusion, ret fusion, braf mutation, nrg1 fusion, met alteration, kras mutation, etc.

Eligibility criteria:
inclusion criteria: 1. understand the requirements and contents of the clinical trial, and provide a signed and dated informed consent form. 2. age ≥ 18 years. 3. histologically or cytologically confirmed, stage iv nsclc. 4. oncogenic mutations confirmed by an accredited local laboratory, including egfr, alk, ros1 etc. 5. ecog 0-1. 6. predicted survival ≥ 12 weeks. 7. adequate bone marrow hematopoiesis and organ function 8. presence of measurable lesions according to recist 1.1. exclusion criteria: the patient did not match from the inclusion criteria.
study the effect of electroacupuncture on prevention and treatment of hypotension after intraspinal anesthesia

Conditions: Hypotension

Summary: the purpose of this study is to assess the prevention and treatment effect of transcutaneous acupoint electrical stimulation on hypotension after intraspinal anesthesia.

after being informed about the study and potential risks, all patients giving written informed consent will undergo the doctors' and researchers' examination to determine eligibility for study entry. at beginning of the study, patients who meet the eligibility requirements will be randomized in a open manner（participant and electroacupuncture executor）in a 1:1 ratio to teas group (10 minutes before intraspinal anesthesia, bilateral neiguan points and zusanli points are given dense wave transcutaneous acupoint electrical stimulation with the frequency of 10/50hz. the intensity is based on the maximum tolerance of the participant, and the stimulation last until 30 minutes after subarachnoid administration) or control group (electrodes are connected at bilateral neiguan points and zusanli points 10 minutes before intraspinal anesthesia, but no transcutaneous acupoint electrical stimulation is given, the duration is the same as that of the teas group).

Eligibility criteria:
inclusion criteria: * 18 years ≤ age \< 55 years * asa classification i \~ ii * full term (37 weeks ≤ gestational weeks \< 42 weeks) * fchedule for elective single cesarean section under spinal anesthesia * no other clinical trial 3 months before the enrollment * volunteer to participate and sign the informed consent form exclusion criteria: * severe preeclampsia or hypertension * diabetes * cardiac insufficiency * mental abnormality or cognitive impairment or inability to communicate * acupuncture points skin breakage, infection, allergy * the researchers believe that there are any conditions that are not suitable for inclusion.
community-based group rehabilitation program for stroke patients with dysphagia

Conditions: Stroke

Summary: community-based exercise programs have demonstrated potential for implementation in older adults; however, it remains imperative to ascertain whether this strategy will yield comparable benefit in stroke patients with dysphagia.participants were randomly assigned to either the intervention group or the control group. patients in the intervention group received swallowing function training in community public spaces for 5 days every week for four-week period (60 minutes per day). patients in the control group received no intervention. penetration-aspiration scale and standardized swallowing assessment (ssa), depressive symptoms (geriatric depression scale-15), and meal duration were assessed before and after all the treatment.

stroke is complicated by oropharyngeal dysphagia in 29 to 81% of patients. up to 40% of these individuals continue to experience swallowing difficulty even after a year later, which is associated with an increased risk of consequences such as aspiration pneumonia, dehydration, and malnutrition. community-based exercise programs have demonstrated potential for implementation in older adults; however, it remains imperative to ascertain whether this strategy will yield comparable benefit in stroke patients with dysphagia.participants were randomly assigned to either the intervention group or the control group. patients in the intervention group received swallowing function training in community public spaces for 5 days every week for four-week period (60 minutes per day). patients in the control group received no intervention. penetration-aspiration scale and standardized swallowing assessment (ssa), depressive symptoms (geriatric depression scale-15), and meal duration were assessed before and after all the treatment.

Eligibility criteria:
inclusion criteria: * age over 65 years old. * no hospitalization within the past six months. * with clear consciousness and able to cooperate with questionnaires and training. * the elderly people who voluntarily participate and agree to adhere until the end of the study. * early dysphagia. exclusion criteria: * complicated with severe liver and kidney failure, tumors, or hematological disorders. * physical disability. * simultaneously receiving other therapies that might influence this study. * individuals with a gastrostomy. * abnormalities of the oral, pharyngeal, or esophageal structures.
research proposal of new technologies and standardization of physiotherapy stroke rehabilitation

Conditions: Stroke

Summary: one of the main goals of physiotherapy in stroke rehabilitation is to maximize walking ability of patients as soon as possible. traditionally, intervention selection and application of neuroplasticity to stroke patients depends on personal preference and experience of therapists. recent development of technologies may provide more accessible, efficient, objective, intensive and predictive methods compared to traditional practices in facilitating the process of recovery after brain injury and standardizing stroke rehabilitation programs. a clinical quality improvement program named accelerated stroke ambulation program (asap) was started in stroke rehabilitation program tai po hospital by physiotherapy department since 2019, pilot period from october 2019 to september 2020 and execute as standard practice afterward.

the goal of asap was to facilitate maximal walking ability of stroke patients by standardized application of modern technologies. asap features standardized functional assessment, standardized intensive early ambulation with modern technologies such as knee-ankle-foot orthoses, lower limb robotic-assisted gait training and video-guide training. in order to monitor the progress of each patient proactively, stroke registry and reference modified rivermead mobility index (mrmi) gain were developed. stroke registry was a longitudinal stroke rehabilitation database to monitor patients' functional outcome and therapists' intervention compliance. reference mrmi gain was a clinical prediction model based on big data concept to support goal-orientated approach of physiotherapists in stroke rehabilitation. stroke treatment library, a standardized exercise prescription in video format was also developed to facilitate standardized prescription of interventions to patients with different level of ability.

Eligibility criteria:
inclusion criteria: patients with principal diagnosis of cerebrovascular accident, stroke, or hemiplegia and had received has received physiotherapy gym session training in a hospital in hong kong between the periods from 1 october 2018 to 31 september 2019 and from 1 october 2020 to 31 september 2021. exclusion criteria: transfer out of the hospital, discharged against medical advice or died.

Keywords: stroke rehabilitation physiotherapy
the utility of second generation colon capsule endoscopy in ulcerative colitis

Conditions: Colitis, Ulcerative

Summary: the purpose of this study is to investigate the accuracy of second generation colon capsule (c2) in evaluating colonic mucosal inflammation of ulcerative colitis patients, using conventional endoscopy as the gold standard.

consecutive patients with ulcerative colitis will be recruited. second generation colon capsule endoscopy (c2) and conventional colonoscopy will be performed one after another on the same day. colonic mucosal inflammation will be scaled by physicians who review c2 videos and those who perform conventional colonosocpies independently. physicians who review c2 videos and colonoscopists will be blinded to the findings of colonoscopies and c2 videos, respectively.the accuracy of c2 in evaluating mucosal inflammation will be evaluated, using conventional endoscopy as the gold standard.

Eligibility criteria:
inclusion criteria: * age 18-80 years * suspected or known uc * written informed consent exclusion criteria: * patients with severe uc according to truelove and witts' criteria * current pregnancy/lactating * patients with a pacemaker or other implanted electromedical device * the presence of dysphagia * patients at higher risk of capsule retention (including crohn's disease, small bowel tumor, radiation enteropathy, previous intestinal surgery, acute abdominal pain without regular defecation) * patients with a contraindication to bowel preparation (congestive heart failure, renal insufficiency, a life-threatening condition) * patients with an allergy to polyethylene glycol, sodium phosphate solution, metoclopramide or bisacodyl suppository

Keywords: capsule colonoscopy ulcerative colitis
physical therapy rehabilitation program combined with music on pediatric with lower limb burn

Conditions: Lower Limb Burn

Summary: the purpose of the current study was to evaluate the effect of physical therapy rehabilitation program combined with music therapy on pediatric with lower limb burn. methods. a twelve-week randomized controlled study including thirty lower limb pediatric burned patients who randomly divided into two groups, group(a) received physical therapy rehabilitation program combined with music therapy in addition to routine medical care while group (b) received physical therapy rehabilitation program without music therapy. pain was assessed by visual analogue scale (vas) and range of motion (rom) was assessed by goniometer, and gait assessed by gait rite. assessment was carried before and after treatment


Eligibility criteria:
inclusion criteria: * lower limb 2nd degree burn since 6 weeks * burn affect skin around ankle and knee joint, * both sex, age ranged between 10 to 15 years old * patients have sufficient cognition and education enough to understand the requirements of this study exclusion criteria: * all patients with age more than 15 years or less than 10 years * patients with hearing problems * acute viral diseases, acute tuberculosis, mental disorders * those with pace makers, diabetics, cardiac, renal patients * patients with genetic disease * 3rd degree burn and 1st degree bum
conservative management of dequervain's tendinopathy with an orthopaedic manual therapy approach emphasizing first cmc manipulation: a retrospective case series

Conditions: DeQuervain's Tendinopathy

Summary: this is a retrospective review of three patients with dequervain's tendinopathy (dqt) that had successful outcomes with a manual therapy focused approach provided by physical therapist management.

dequervain's tendinopathy (dqt) is a musculoskeletal disorder that limits hand function of affected individuals. management of dqt can include splinting, activity modification, medications, corticosteroid injections, physical therapy, and surgery. there is limited evidence to support the combination of manual therapy and exercise interventions within an orthopaedic manual physical therapy (ompt) approach when managing patients with dqt. three patients identified with dqt underwent a multi-modal treatment regimen including carpometacarpal (cmc) thrust and non-thrust manipulation, end range radiocarpal mobilization, mobilization with movement (mwm), strengthening exercises, and grip proprioception training. outcomes were assessed using the numeric pain rating scale (nprs), jamar hand dynamometer grip strength, and the quick disabilities of the arm, shoulder, and hand (quick dash) questionnaire. these measures were administered at baseline and discharge.

Eligibility criteria:
inclusion criteria: five or more items present on the dqt screening tool devised by batteson et al.: * pain over the radial styloid * tenderness over the dorsal thumb * pain with active thumb flexion * localized swelling over the thumb * positive finkelsteins test * thickening of the tendon sheath of the first dorsal extensor compartment * pain with resisted thumb extension. exclusion criteria: * cardiovascular disorders * non-musculoskeletal complaints * auto-immune disorders * patients who had received previous treatment for their condition

Keywords: dequervain's tendinopathy cmc manipulation physical therapy
physiological effects of expiration with the glottis open in lateral posture (eltgol) and flutter valve in patients with bronchiectasis

Conditions: Bronchiectasis

Summary: this study aimed to evaluate the acute physiological effects of expiration with the glottis open in lateral posture (eltgol) and flutter valve in dynamic and static lung volumes in patients with bronchiectasis and, secondarily, to study the effect of these techniques in sputum production.


Eligibility criteria:
inclusion criteria: patients with clinical and radiological criteria of bronchiectasis exclusion criteria: * heart failure * pneumonia * chest pain * inability to perform the procedures * asthma * cystic fibrosis