Kornimate/medical-research-clean huggingface dataset:
clinical validation study of rtvue features

Conditions: Healthy; Glaucoma

Summary: to perform a clinical validation study of rtvue features in volunteers with various ocular pathology or no ocular pathology.

clinical validation study of rtvue features in volunteers with various ocular pathology or no ocular pathology. subjects to undergo a clinical exam and oct scanning.

Eligibility criteria:
inclusion criteria: * normal subjects will have normal results from the clinical exam and be free of ocular pathology. * glaucoma patients will have clinical exam results consistent with glaucoma; they will have visual field defects consistent with glaucoma and/or structural damage consistent with glaucoma. * retina patients will have clinical exam results consistent with retina pathology. exclusion criteria: * normal subjects will be free of any ocular pathology. * glaucoma patients will be free of any ocular pathology except glaucoma. * retina patients will be free of any ocular pathology except any type of retina pathology.

Keywords: retina pathology
premedical is a clinical investigation aiming to create a data basis that can be used to enrich information collected in the course of the classic patient journey. patients in the emergency department will be asked to answer patient-related and symptom-oriented questions. minimum age is 18 years

Conditions: Emergency Department Triage

Summary: the goal of this clinical investigation is to create a new type of data basis that can be used to enrich information collected in the course of the classic patient journey, such as medical history forms and discharge letters. therefore, it is planned to collect new, patient-related and symptom-oriented data on site and directly from patients in the emergency department (female/male; at least 18 years old). the main question it aims to answer is: - can a detailed medical history with additional enriched information from xund improve the quality of outpatient care? selected patients in the waiting area of the emergency department will record their symptoms on a tablet and answer the questions asked about their symptoms.


Eligibility criteria:
inclusion criteria: * a signed informed consent form; * signed consent and admission to the emergency department of the emergency medicine clinic * triage category 3, 4 or 5 based on the triage procedure according to the manchester triage system used in austria * the physical and mental ability to operate the tablet and answer the questions * 18 years of age or older; * knowledge of the german language. exclusion criteria: * not meeting all inclusion criteria

Keywords: xund emergency department symptom check patient journey
postoperative recovery and comfort in patients undergoing urologic robotic surgery

Conditions: Quality of Recovery; Urology; Pain; PONV; Postoperative Complications; Laparoscopic

Summary: previously published studies show that adding intrathecal morphine to general anesthesia can reduce the postoperative pain and length of stay (los) in varies types of surgery. a recent meta-analysis showed that the addition of intrathecal morphine at doses below 500µg did not increase the risk of respiratory depression compared with a control group receiving intravenous opioids. epidural analgesia is uncommonly used for robot-assisted laparoscopic procedures due to the limited surgical trauma. in addition, the risks associated with the epidural itself such as infection and spinal hematoma are thought to outweigh its possible benefits for these procedures. at linkoping university hospital a combination of general anesthesia and intrathecal morphine in robot-assisted laparoscopic radical prostatectomy and in robotic-assisted laparoscopic cystectomy is now routinely used in order to improve postoperative recovery. however whether this approach is beneficial in other types of robotic-assisted urological procedures is unknown. therefore the investigators aim to conduct a feasibility study for the use of intrathecal morphine combined with general anaesthesia in adult patients undergoing elective urologic laparoscopic robot-assisted surgery at linkoping university hospital. the investigators will include 30 patients in the study. the specific aims are to investigate the feasibility and sensitivity of quality of recovery 15 (qor15), as an outcome tool measuring postoperative well-being in this patient cohort. the investigators will also investigate the feasibility of other outcome measures such as postoperative pain, post-anesthesia care unit los, occurrence of pruritus and hospital los. for planning of the timeframe of the future interventional study the investigators will use this feasibility study to examine the inclusion rate of study patients.


Eligibility criteria:
inclusion criteria: * scheduled for elective urologic robotic assisted laparoscopic surgery in linkoping university hospital exclusion criteria: * age \<18 * not expected to comprehend the written or verbal study information * patient planned for robotic assisted laparoscoic prostatectomy or robotic assisted laparoscopic cystectomy * acute surgery * asa class \>3 * major surgery on another organ planned at the same operation * patient planned for a neuraxial blockade in addition to general anaesthesia. * study personal not available
antioxidant supplements in cystic fibrosis children

Conditions: Cystic Fibrosis (CF)

Summary: this randomized controlled clinical trial included 60 pediatric patients with cystic fibrosis (cf) assigned randomly into two arms; arm 1(extra care arm):received a tailored dietary plan following mediterranean diet to cover macronutrients needs according to recommended daily allowance (rda) for age, with antioxidant supplements in specific doses in oral liquid form (200 mg vitamin e, 300 mg vitamin c, 90 μg se, 500 μg vitamin a, 30 mg zinc, 3 mg copper and 2000 iu vitamin d) for 6 months. arm 2: recieved tailored dietary plan following mediterranean diet as arm 1 with fat soluble vitamins supplementation (150 μg vitamin a, 2000 iu vitamin d, 100 mg vitamin e and 1000 μg vitamin k) for 6 months. this study aimed to evaluate the effect of antioxidants supplementation on the level of oxidative stress, as measured by 3-nitrotyrosine, bacterial colonization and diseases severity among cf children.


Eligibility criteria:
inclusion criteria: * patients with documented diagnosis of cystic fibrosis (cf) who were diagnosed according to cf foundation guidelines based upon positive sweat tests and/or the presence of a mutation in the homozygous state or two heterozygous mutations on the gene encoding the cystic fibrosis transmembrane conductance regulator (cftr) protein exclusion criteria: * patients with current pulmonary exacerbations. * patients with severe sepsis. * patients with comorbid systemic illnesses.
efficacy of narrow band spectrum endoscopy for the diagnosis of gastric antral vascular ectasia in patients with liver cirrhosis

Conditions: Gastric Antral Vascular Ectasia

Summary: the study aims to evaluate the role of similar technology of narrow band imaging vist video intelligent staining technology in the diagnosis of gastric antral vascular ectasia in cirrhotic patients

vist (video intelligent staining technology) is used to the diagnosis of gave as the form of ectatic vessels in the antrum in instead of erosions in the antrum by white light endoscopy which can mislead the diagnosis to portal hypertension gastropathy. targeted biopsies are taken and examined histopathologically in order to see if matching with vist view. in addition, cd61 is used to highlight the diagnosis for more confirmation. cd61 is an immunohistochemistry platelets marker.

Eligibility criteria:
inclusion criteria: * patients with mucosal vascular lesions at the gastric antrum suspicious of gave of a linear striped form or a diffuse punctate form upon conventional wle exclusion criteria: * connective tissue disorders like systemic sclerosis. * chronic kidney disease. * recent use of proton pump inhibitors in the last 14 days. * history of gastric surgery or gastric cancer. * pernicious anemia. * recent history of non-steroidal anti-inflammatory drugs intake

Keywords: narrow band
mri scan and intra-labyrinthine schwannoma

Conditions: Schwannoma

Summary: evaluate the interest of gadolinium for the positive and topographic diagnosis of intra-labyrinthine schwannoma, comparing t1 sequence acquired after gadolinium injection to a sequence of fast imaging type employing steady state acquisition (fiesta-c)


Eligibility criteria:
inclusion criteria: * age 18-80 years * have intra-labyrinthine schwannoma * have benefited from an mri with gadolinium injection on the mri 3t with interpretable sequences of good quality * subject giving their consent for their participation * subjects who benefited, between 2009 and 2016, from an mri of the external auditory canals, with gadolinous product injection and on the 3 tesla mri, in which a diagnosis of intra labyrinthine schwannoma was made exclusion criteria: - refusal to participate in the study

Keywords: intra labyrinthine schwannoma schwannoma magnetic resonance imaging (mri) gadolinium t2 weighted gradient echo
sils cholecystectomy: cholangiography of the biliary tract

Conditions: Cholecystolithiasis

Summary: single incision laparoscopic surgery (sils) can be performed for different standard operations such as appendectomy and cholecystectomy. during laparoscopic cholecystectomy sometimes a cholangiography (marking the biliary tract with contrast agent) is necessary to identify and preserve relevant structures. the investigators want to evaluate feasibility of performing cholangiography during sils cholecystectomy.


Eligibility criteria:
inclusion criteria: * cholecystolithiasis exclusion criteria: * acute cholecystitis

Keywords: cholelithiasis
a family program for childhood overweight and obesity

Conditions: Overweight and Obesity

Summary: childhood overweight and obesity is a health problem with lifelong implications related to diabetes, hypertension, cardiovascular disease, psychological disorders as well as other chronic conditions.

in taiwan, the nationwide prevalence of overweight and obesity among school-age children aged 7 to 11 years has also increased over the past years. sleep and weight are intricately related. school-age children requires at least 10 hours of sleep per night but children in asian countries are on average obtaining shorter sleep than children in caucasian countries.

Eligibility criteria:
inclusion criteria: * children with overweight and obesity exclusion criteria: * children with any other chronic or acute medical conditions
study of 0417 ointment in the treatment of atopic dermatitis

Conditions: Atopic Dermatitis

Summary: the aim of this trial is to assess the efficacy of 0417 ointment in the treatment of atopic dermatitis. treatment medication will be administered as follows: apply a thin layer of ointment to affected skin areas twice daily and rub in gently and completely. study medication will be applied twice a day, approximately 12 hours apart, for approximately 4 weeks.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of atopic dermatitis * good health with the exception of atopic dermatitis * percent body surface area minimum requirements exclusion criteria: * subjects who are pregnant, nursing, or planning a pregnancy within the study participation period. * subjects who have any systemic or dermatological disorders with the exception of atopic dermatitis

Keywords: atopic dermatitis
measurments of bbb breakdown in the pathogenesis of psychiatric disorders

Conditions: Psychosis

Summary: bbb dysfunction has been indicated in some groups of schizophrenia patients by measuring increased albumin and immunoglobulin (igg) cerebrospinal fluid (csf) levels. most of the authors described a raised protein level in 5-20% of the schizophrenic patients (muller \& ackenheil, 1995). increased s100b levels were demonstrated in the serum of patients suffering from schizophrenia as well as depression, and this may reflect increased bbb permeability. furthermore, this increase remains in those patients who develop a residual state with relevant negative symptoms, whereas s100b levels normalize in recovering patients (shalev, serlin \& friedman, 2009). csf albumin and csf igg values correlate significantly with some of the sans (scale for the assessment of negative symptoms) subscales and the sans total score, this shows the correlation between bbb permeability and behavioral changes. it is important to say that although negative symptoms are often signs of chronicity of the disease, the abnormal csf findings in muller's experiment (1995) are not related to the duration of the disease, because the patients were quite young and the duration of the disease was less than 3 years. the investigators hypothesize that a primary vascular pathology, which leads to bbb breakdown, will result a leakage of serum-derived vascular components in to the brain tissue and may cause brain dysfunction such as disturbed thinking processes, mood and behavior, as we can see in psychiatric patients.


Eligibility criteria:
inclusion criteria: psychotic, affective disorders or anxiety disorders patients admitted to soroka medical center from the psychiatric hospital or self admissions to the psychiatric department. patients were evaluated by study psychiatrist. signed informed consent by the patient or his legal custodian. subjects age 16-65 years. - exclusion criteria:1. patients with neurological disease, including epilepsy, ischemic stroke, multiple sclerosis, parkinson's disease, etc. 2. drug or alcohol abuse. 3. patients that will need anesthesia in order to perform the mr study (not including patients who are already ventilated). 4. patients with metal foreign body, or other contraindication to mr (according to the mr regulations). 5. tourists or foreign residents that long terms follow up is not feasible for them. 6. patients with renal failure / any other kind of kidney problems. 7. pregnant women. 8. patient with brain-injury. 9. suicidal patients/patients with high risk for suicide/violent patients or patients that their condition might deteriorate due to participation in this study. -

Keywords: psychotic patients
post-op ketamine study

Conditions: Osteo Arthritis Knee

Summary: the purpose of this study is to establish the effect of sub-anesthetic dosing of ketamine with spinal anesthesia during total knee arthroplasty on post-operative pain and narcotic consumption. we hypothesize that sub-anesthetic ketamine will decrease post-operative pain and narcotic consumption and may secondarily lead to shorter lengths of stay, faster rehabilitation, improved postoperative outcomes and patient satisfaction.


Eligibility criteria:
inclusion criteria: * 18 - 85 years of age * asa i - iv * undergoing primary unilateral elective total knee arthroplasty with spinal anesthesia exclusion criteria: * bmi over 40\* * contraindication or allergy to opioid pain medication or ketamine\* * daily opioid use for pain control before surgery in excess of systemic morphine equivalent to 10 mg\* * ejection fraction (ef) less than 30% * creatinine clearance less than 30 ml/min\* * history of chronic liver failure * desire for nerve block or general anesthesia * any neurologic or psychiatric disorder (including bipolar disorder, post traumatic stress disorder, schizophrenia) * prior surgery on ipsilateral knee within the last 6 months * alcohol abuse
a community-based educational intervention to improve colorectal cancer screening

Conditions: Colorectal Carcinoma

Summary: this study investigates the facilitators and barriers to colorectal cancer screening in underserved populations with a focus on african american, latinx, and asian (chinese) in the sidney kimmel cancer center catchment area. learning what encourages people and what keeps people from getting colorectal cancer screening may help researchers develop an educational tool for colorectal cancer screening that addresses colorectal cancer knowledge, beliefs, and cultural factors in underserved populations.

primary objective: i. develop a culturally tailored colorectal cancer education intervention for underserved and under-represented populations with a focus on african american, latinx, and asian (chinese) in the sidney kimmel cancer center catchment area. outline: key contact interviews: participants participate an interviews over 60 minutes focusing on identifying facilitators and barriers to colorectal cancer screening, essential cultural factors to include in the educational intervention, and insights into the best use of the national cancer institute (nci)'s screen to save materials. focus groups: participants attend focus groups over 60-90 minutes to examine and define further facilitators and barriers to colorectal cancer, cancer knowledge and beliefs, essential cultural factors to include in the educational intervention, insights into the best use of the nci's screen to save materials, and identification of factors to consider for dissemination and sustainability. after completion of study, participants are followed up for up to 12 weeks.

Eligibility criteria:
inclusion criteria: * • focus groups may be facilitated in chinese (mandarin), english, or spanish depending on participant preference exclusion criteria: * • individuals who do not meet the inclusion criteria * individuals who have been diagnosed with colorectal cancer
a novel technique for the removal of pterygiums

Conditions: Pterygium

Summary: the aim of this study is to introduce a new surgical technique for the removal of pterygiums that entails the use of bipolar electrocautery to secure the graft, rather than sutures. with this, the objective is to evaluate the benefits of a new technique for pterygium surgery with respect to postoperative patient comfort, surgery time, cost and recurrence rate.


Eligibility criteria:
inclusion criteria: * patients with one or more pterygiums over age 18 exclusion criteria: * patients with glaucoma

Keywords: pterygium pterygiums pterygia graft autograft excision surgery eye electrocautery polyglactin
a post marketing surveillance study assessing the long-term efficacy and safety of aptivus co-administered with low-dose ritonavir in treatment experienced patients with hiv-1 infection in the daily clinical practice.

Conditions: HIV Infections

Summary: the aim of this trial is to evaluate the safety and virological and immunological efficacy of aptivus in treatment-experienced patients with advanced hiv-1 infection who had developed resistance to more than one protease inhibitor.


Eligibility criteria:
inclusion criteria: 1. hiv-1 infected patients who are treatment experienced and infected with hiv-1 strains resistant to more than one protease inhibitor and no other therapeutic options. 2. the inclusion criteria follow the same criteria which are describe in the newest spc exclusion criteria: the exclusion criteria follow the same criteria which are describe in the newest spc
miniinvasive corneal neurotization. a pilot study.

Conditions: Neurotrophic Keratitis

Summary: neurotrophic keratitis (nk) is a degenerative disease of the cornea due to the impairment of the nasociliary branch of the ophthalmic nerve. reduced corneal sensation lead to several corneal lesions including spontaneous ulcerations, delayed wound healing, corneal scarring, neovascularization, thinning, perforation or infection. an important and permanent visual loss of is frequently associated with the condition. nk can be congenital or acquired. its acquired forms can be due to traumatic, infectious (herpes, zoster), neoplastic or iatrogenic causes. there is currently no specific medical treatment. surgical reconstruction techniques of sensory neurotizations have recently been described in young patients suffering traumatic, congenital or neoplastic nk using supratrochlear nerves as the sensory donor nerves and sural nerve as healthy graft. a neurotization involves the transfer of a healthy donor nerve segment into a tissue to reestablish either motor or sensory innervation. the aim of the present study is to assess the outcomes of a novel sensory neurotization technique for the treatment of severe nk in adult patients (stages 2 and 3 of mackie classification). corneal neurotizations will be performed using either ipsilateral supraorbital nerve as donor nerve (direct neurotization) or contralateral supraorbital nerve as donor nerve and a segment of the lateral antebrachial cutaneous nerve as graft. small-size skin incisions (less than 3 centimeters) will be made in one or both eyebrow and an endoscopic device will help the surgeons to localize and dissect the supraorbital nerve. donor nerves or graft will be sutured to the neurotrophic corneas. adult patients with unilateral nk due to infectious, traumatic or iatrogenic causes will be included.


Eligibility criteria:
inclusion criteria: * patient older than 18. * nk stages 2 and 3 (mackie's classification). * non-response to maximal medical treatment (lachrymal substitution, autologous serum). * postherpetic or post-zoster nk (group 1). * postoperative nk (neurosurgery and trigeminal thermocoagulation) (group 2). * posttraumatic nk (orbital trauma, ocular burn) (group 3). * no ocular hypertony in both eyes. * visual acuity \> 20/40 on the contralateral eye. * written consent of the patient. * patient benefiting from national health coverage (either as a direct user or beneficiary). exclusion criteria: * impossibility of general anesthesia. * herpetic or zoster recurrence in the 6 months prior surgery. * length of nk evolution \> 5 years. * congenital nk. * bilateral nk. * other causes of nk: diabeta mellitus, amylosis, sarcoidosis, multiple sclerosis, vitamin a or b12 deficiency, sjögren syndrome, gvh disease, topical nsaid, topical beta-blockers, history of refractive surgery. * mental illness. * adult with legal guardian or guardianship. * pregnancy. * breast-feeding. * patient's unable to understand informations.
bone-sparing chemoradiotherapy for anal cancer - dacg-ii

Conditions: Anal Cancer; Radiotherapy Side Effect

Summary: this study proposal includes a prospective clinical trial of bone sparing treatment planning in anal cancer patients. the trial aim to lower the risk of bone damage, while adhering with the constrains to the bowel, bladder and other conventional organs at risk, and finally to describe the fraction of pelvic insufficiency fractures in patients treated with optimized radiotherapy.

patients will receive standard (chemo)-radiotherapy according to national danish anal cancer group (dacg) guidelines, but the bone-sparing focus will be added to the algorithm for dose-constrains and planning objectives. a bone specific magnetic resonance scan will be performed at 1 year post treatment. additional substudies include collection of blood samples for translational research purposes.

Eligibility criteria:
inclusion criteria: * patients with biopsy verified localized squamous cell anal cancer * indication for standard (chemo)-radiotherapy with curative intend for anal cancer as per multidisciplinary team decision * clinical eligible for standard (chemo)-radiotherapy as per physicians' decision * written and oral consent * age at least 18 years exclusion criteria: * previous pelvic radiotherapy * previous systemic therapy with severe bone marrow suppression or hematological diseases * hip-replacements * contraindications to mri-scan