Kornimate/medical-research-clean huggingface dataset:
self-administered acupressure for depression

Conditions: Depressive Symptoms; Depressive Disorder; Depression

Summary: the goal of this clinical trial is to examine the effects of self-administered acupressure intervention for alleviating depressive symptoms among people with depression. it is hypothesized that the self-administered acupressure group would have a great improvement in depressive symptoms as measured by the patient health questionnaire compared with the mental health education group across the 12-week intervention period. the main questions it aims to answer are: * is the self-administered acupressure intervention more effective for alleviating depression and other related outcomes compared to the mental health education group among depressed individuals? * is the self-administered acupressure intervention acceptable and feasible for depressed individuals to alleviate depression? participants will be randomized into self-administered acupressure group or mental health education group based on the group allocation with a 1:1 ratio. participants will attend two weekly 120-min self-administered acupressure training or mental health education, respectively.


Eligibility criteria:
inclusion criteria: 1. hong kong residents aged 18 to 65 2. can communicate in cantonese and comprehend written chinese 3. have moderate or above-level depression as measured by the phq-9 with a score of 10 or above 4. willing to give informed consent and comply with the trial protocol. exclusion criteria: 1. have the phq score of 20 or above (referral information to community psychological services will be provided) 2. new onset or change of antidepressant medication or dosage in the last 3 months 3. previous or current diagnosis of schizophrenia, other psychotic disorders, or bipolar disorder as screened using the chinese version of the structured clinical interview for diagnostic and statistical manual of mental disorders. 4. have cognitive impairment diagnosed by the hong kong montreal cognitive assessment with a score \< 22 5. skin lesions or infections at the treatment sites 6. significant suicidal risk as rated by the hamilton depression rating scale item on suicide (score ≥3) 7. pregnant or childbearing potential but not using adequate contraception 8. with any major medical condition that causes depression based on the judgement of a psychiatrist.

Keywords: depression acupressure randomized controlled trial
development of an instrumental activities of daily living scale

Conditions: Spinal Cord Injury

Summary: this study is to develop an iadl scale for patients with sci (iadl-sci) and examine its psychometric properties in three years.

this study is to develop an iadl scale for patients with sci (iadl-sci) and examine its psychometric properties in three years. in the first year, we will devote ourselves to the development of iadl-sci - first version. about 150 patients will be recruited in this year. in the second year, the study will be focused on investigating the psychometric properties of iadl-sci in order to construct the formal version of iadl-sci in about 120 patients with stable condition. in the third year, we will be engaged in analyzing and comparing the psychometric properties of the three iadl scales (iadl-sci, frenchay activities index, and lawton iadl) to confirm that iadl-sci is the best among the three. about 50 inpatients receiving rehabilitation will be recruited in this year.

Eligibility criteria:
inclusion criteria: patients with spinal cord injury exclusion criteria: patients with other major diseases (e.g., cancer)

Keywords: psychometrics activities of daily living
clinical and psycho-social impact of covid-19 related confinement on patients with digestive tumors

Conditions: Chemeotherapy; Immunotherapy; Treatment Mofidied; Coronavirus; Quality of Life

Summary: to limit corona virus dissemination on its territory, france applied strict confinement from march 16th to may 11th. scientific societies recommended treatment modifications and remote consultations that were applied. this study evaluates the clinical impact of these care adaptation on patients under treatment for a digestive tumor. a special focus is made on quality of life and psycho-social impact of treatment modifications on patients diagnosed with metastatic colorectal cancer and metastatic pancreatic cancer.


Eligibility criteria:
inclusion criteria: * histologically proven digestive tumor * ongoing treatment from march,1st and april 30th exclusion criteria: * patient refusal for enrollment in the study * patient not recognised legally competent
single incision laparoscopic cholecystectomy using a flexible endoscope and ethicon manually articulating devices (mad)

Conditions: Cholelithiasis; Pain

Summary: the aim of this study is to improve the technique of laparoscopic cholecystectomy by using a flexible endoscope passed through a single umbilical skin incision, as previously reported, now with the use of manually articulating devices (ethicon endo-surgery, inc.) through the endoscope.

single incision laparoscopic surgeries (sils) have taken a step further the field of minimally invasive surgery with reports of a variety of laparoscopic procedures performed through a single incision. however the technique is challenging due to the proximity of the instruments passed through the single umbilical skin incision. several improvisions were made to accommodate this technical restriction by making flexible umbilical ports that accommodate several trocars, or usage of different length instruments to strategically place the surgeons, minimizing collision and improving ergonomics. the flexibility of the endoscope will allow improved freedom of movement within the abdominal cavity and ease of gallbladder dissection. the investigators believe that this technique will take advantage of the flexible nature of the endoscope while avoiding the risks of transluminal surgery inherent in natural orifice surgery. flexible endoscope offers an excellent solution to sils, with its flexible optics and ability to pass working instruments through it. the flexible endoscope to be used ia a 12mm dual channel karl storz or olympus gastroscope.ethicon instruments are essentially like traditional endoscopic instruments with an extra joint at the working end, mimicking a wrist joint. these instruments are fda listed/cleared pursuant to 510(k) provisions of the food, drug and cosmetic act with general indications for use in endoscopic or laparoscopic procedures. we will be using an articulating grasper, articulating biopsy forcepts, and an articulating needle knife. we will measure pain with pain scales.

Eligibility criteria:
inclusion criteria: * uncomplicated biliary colic * asa i or ii exclusion criteria: * pregnant women * children * institutionalized mentally disabled * prisoners

Keywords: cholelithiasis single incision flexible endoscope ethicon manually articulating device pain
the bicuspid aortic stenosis following transcatheter aortic valve replacement registry

Conditions: Aortic Valve Stenosis; Cardiovascular Diseases; Heart Valve Diseases; Bicuspid

Summary: the purpose of this study is to evaluate the clinical outcomes of transcatheter aortic valve replacement (tavr) in patients with bicuspid aortic valve stenosis.

this registry is a subgroup of asian tavr registry(nct02308150) and asian tavr registry changes to tp-tavr registry(nct03826264). some subjects moved to tp-tavr registry and continue to 10-year follow-up.

Eligibility criteria:
inclusion criteria: * patients with bicuspid aortic valve stenosis who are not candidates for surgical aortic valve replacement because of coexisting illnesses. * the patient or guardian agrees to the study protocol and the schedule of clinical follow-up, and provides informed, written consent, as approved by the appropriate institutional review board/ethics committee of the respective clinical site.

Keywords: transcatheter aortic valve replacement
a deep learning method to predict difficult laryngoscopy using cervical spine x-ray image

Conditions: Thyroid; Surgery; Intubation; Difficult or Failed

Summary: an unanticipated difficult laryngoscopy is associated with serious airway-related complications. the investigators developed a deep learning-based model that predicts a difficult laryngoscopy (cormack-lehane grade 3-4) from a cervical spine lateral x-ray using data from 14,135 patients undergoing thyroid surgery. this model showed excellent predictive performance, which was higher than that of other deep learning architectures. in this study, the investigators prospectively validate the model for predicting a difficult laryngoscopy and compare predictive power with clinical airway evaluation.

predicting a difficulty of a laryngoscopy is important for patient safety, as an unanticipated difficult laryngoscopy is associated with serious airway-related complications, such as brain damage, cardiopulmonary arrest, or death. although clinical predictors, such as the modified mallampati classification, thyromental distance, inter-incisor gap, and the upper lip bite test, are used for airway evaluation in clinical practice, these indicators have low sensitivity and large inter-assessor variability and require patient cooperation. the investigators developed a deep learning-based model that predicts a difficult laryngoscopy from a cervical spine lateral x-ray using data from 14,135 patients undergoing thyroid surgery. and this study is under submission. this deep learning model showed the highest performance in predicting difficult laryngoscopy compared to other deep learning models (vgg-net, resnet, xception, resnext, densenet, and senet) with a sensitivity of 95.6%, a specificity of 91.2%, and an area under roc curve (auroc) of 0.972. however, as the model was a retrospective design using existing medical records, the presence or absence of cricoid pressure to obtain the optimal laryngoscopy was not evaluated, and not compared with airway evaluations. in this study, the investigators prospectively validate the model for predicting a difficult laryngoscopy and compare predictive power with clinical airway evaluation. if this study prospective confirm our results, this approach can be helpful in improving patient safety and preventing airway-related complications through objective and accurate airway evaluation.

Eligibility criteria:
inclusion criteria: * elective thyroid surgery under general anesthesia exclusion criteria: * age \< 18 years * no c-spine lateral x-ray image obtained within 3 months before surgery * patient who safety is not guaranteed when using a direct laryngoscope. (poor dental condition, risk of neck extension) * patients who not cooperate with the physical examination for airway evaluation

Keywords: deep learning cervical spine x-ray difficult laryngoscopy
diagnostic properties of aldosterone-renin ratio in primary aldosteronism among hypertensives.

Conditions: Hyperaldosteronism; Hypertension

Summary: this study aims to evaluate the diagnostic value of the aldosterone-renin ratio (arr)as a screening test for primary aldosteronism among hypertensives. the test characteristics will be studied. furthermore, the effect of eplerenone, a selective aldosterone-receptor antagonist will be studied.

although primary aldosteronism (pa) was formerly seen as a rare cause of hypertension, this condition is now thought to be the commonest cause of secondary hypertension, with the prevalence ranging up to 10-15 % of all hypertensives. identification of patients with pa allows for specific treatment, for instance unilateral adrenalectomy in case of an aldosterone-producing adenoma or the administration of an aldosterone-receptor antagonist in case of bilateral adrenal hyperplasia. since the introduction of the aldosterone-renin ratio (arr) as a screening tool for pa in 1981, there has been considerable debate about the diagnostic value. the values for aldosterone and renin are highly dependent on many factors, including posture, time of day and medication. also, the cut-off values for the identification of pa remain controversial. this study aims to evaluate the test characteristics of the arr in a population of patients with therapy-resistant hypertension, the dependence of the arr on medication type and the predictive value on the response on eplerenone, a selective aldosterone-receptor antagonist.

Eligibility criteria:
inclusion criteria: * age 18-65 years * blood pressure above 140 mmhg systolic and above 90 mmhg diastolic * use of at least 2 antihypertensive drugs exclusion criteria: * known cause of hypertension, including white-coat hypertension * severe renal failure (kreat \> 200 umol/l) * bmi above 32 kg/m2 * poorly regulated diabetes mellitus (hba1c \> 8.0 %) * heart failure * stroke or myocardial infarction within 6 months before inclusion * angina pectoris * pregnancy * neoplastic disease, within 5 years before inclusion * alcohol abuse

Keywords: primary aldosteronism hypertension aldosteron-renin ratio eplerenone aldosteron-receptor antagonist screening
culturally tailored nurse coaching study for cancer symptom management

Conditions: Dehydration; Symptom Cluster; Quality of Life; Self Efficacy; Chemotherapy Effect

Summary: the purpose of the study is to see whether or not a telephone/ text message intervention, delivered by a registered nurse, is helpful in managing symptoms and can also prevent dehydration caused by chemotherapy treatment when given together for patients with metastatic breast, colon, lung or prostate cancer.


Eligibility criteria:
inclusion criteria: 1. eligible for chemotherapy for the first time (previous \& ongoing hormonal only treatment allowed or neoadjuvant \& adjuvant chemotherapy regimens with 2+ drugs allowed) 2. \> 18 years old 3. eastern cooperative oncology group (ecog) performance status 0-2. 4. there are no life expectancy restrictions 5. women of child-bearing potential are allowed in the study as long as they are eligible for the chemotherapy treatment. 6. ability to understand and the willingness to sign a written informed consent document. exclusion criteria: 1. patients on immunotherapy only will be excluded 2. previous chemotherapy 3. under 18 years old 4. medically diagnosed with a cognitive impairment. rationale for excluding people with cognitive impairment is that they would not be able to fully participate in the self-management care aspects of the intervention via the telephone, nor provide informed consent. 5. no access to a telephone 6. blind or deaf; if subject is hearing-impaired or illiterate, then the subject may have a family member participate as a telecommunication surrogate with them in the study

Keywords: symptom self-management symptom severity emotional support
a study of bms-986218 or bms-986218 plus nivolumab in combination with docetaxel in participants with metastatic castration-resistant prostate cancer

Conditions: Prostatic Neoplasms, Castration-Resistant

Summary: the purpose of this study is to assess the safety, efficacy, tolerability, and toxicity of docetaxel alone, in combination with bms-986218, or in combination with nivolumab plus bms-986218 in men who have metastatic castration-resistant prostate cancer (mcrpc) that progressed after novel antiandrogen therapy and have not received chemotherapy for mcrpc.


Eligibility criteria:
inclusion criteria: * histologic confirmation of carcinoma of the prostate without small cell features * documented prostate cancer progression by prostate cancer working group 3 (pcwg3) criteria while castrate * evidence of metastatic disease documented by either bone lesions on radionuclide bone scan and/or soft tissue lesions on computed tomography (ct)/magnetic resonance imaging (mri) * eastern cooperative oncology group (ecog) performance status 0 to 1 * ongoing androgen deprivation therapy (adt) with a gonadotropin-releasing hormone (gnrh) agonist/antagonist or bilateral orchiectomy (i.e., surgical or medical castration) confirmed by testosterone level ≤ 1.73 nmol/l (50 ng/dl) at the screening visit * chemotherapy-naive for metastatic castration-resistant prostate cancer (mcrpc) and have received at least one novel antiandrogen therapy (nat) exclusion criteria: * concurrent malignancy (present during screening) requiring treatment or history of prior malignancy active within 2 years prior to treatment assignment in part 1 or randomization in part 2 * untreated central nervous system (cns) metastases * leptomeningeal metastases * active, known or suspected autoimmune disease other protocol-defined inclusion/exclusion criteria apply

Keywords: bms-986218 bms-936558 docetaxel metastatic mdx1106 nivolumab ono-4538 taxotere
adding vortexing to the maki technique provides no benefit for the diagnosis of catheter-related bacteremia

Conditions: Catheter-related Bloodstream Infection

Summary: the investigators wanted to determine whether the combined use of vortexing and maki techniques provides profitability versus the maki technique for the diagnosis of catheter tip colonization and catheter-related bloodstream infection

background a previous study compared vortexing and maki techniques for the diagnosis of catheter-related bloodstream infection (crbsi), and concluded that vortexing was not superior to maki method. aim to determine whether the combined use of vortexing and maki techniques provides profitability versus the maki technique for the diagnosis of catheter tip colonization (ctc) and crbsi. methods observational and prospective study carried out in an intensive care unit. patients with suspected catheter-related infection (cri) and with one central venous catheter for at least 7 days were included. the area under the curve (auc) of the maki technique, the vortexing technique and the combination of both techniques for the diagnosis of ctc and crbsi were compared.

Eligibility criteria:
inclusion criteria: * patients with suspicion of catheter-related infection (cri) and with long term cvc (at least 7 days) exclusion criteria: * none
online survey on psychological impact of covid-19 epidemic on school-age children

Conditions: Investigating Psychological Impact; Confinement Measures; Coronavirus Outbreak; School-age Children

Summary: the coronavirus outbreak is a stressful event for the whole population. confinement measures are protective against the risk of dissemination of the virus, but they can also lead to several psychological symptoms. in children, a study in china has reported about 20% of depressive or anxious troubles in school-age children after a 4-week period of confinement. in france, confinement lasted about 8 weeks. school resumed on may 11th for primary school children and on june 2nd for secondary school children. in this survey, we aim at exploring the psychological status of these children and the impact on their schooling, for better understanding, support and prevention. through this online questionnaire, we also aim at giving some psycho-education advices. finally, we could identify some subgroups of children particularly vulnerable, and organise some specific support for them in coming months.


Eligibility criteria:
inclusion criteria: * school-age children in the academy of lyon * parental consent exclusion criteria: -

Keywords: coronavirus epidemic children schooling
a long term study of spp100 in patients with essential hypertension (trial is not recruiting in the us)

Conditions: Hypertension

Summary: this study will evaluate the safety and efficacy of long term treatment of spp100 in patients with essential hypertension. (trial is not recruiting in the us)


Eligibility criteria:
inclusion criteria: * diagnosed as essential hypertension - exclusion criteria: * patients with secondary hypertension or suspected of having secondary hypertension. * patients suspected of having malignant hypertension * patients with any serious diseases or symptoms

Keywords: hypertension angiotensin renin aliskiren
better weight-better sleep (bwbs) trial

Conditions: Overweight; Obesity

Summary: the hypothesis of this study is that overweight and obese patients exposed to sleep focused counseling and standard dietary and exercise counseling will have better outcomes than similar patients exposed to standard dietary and exercise counseling only.

objective: to explore the feasibility of integrating sleep management interventions with dietary and exercise interventions for obesity in a 12-week randomized trial. methods: we randomized 49 overweight or obese adult patients either to a better weight (bw) cognitive behavioral intervention, or to a combination of the bw intervention and a better sleep intervention, better weight-better sleep (bwbs). results: the bwbs group lost weight faster (p=.04), and coping self-efficacy accelerated (p=.01). conclusions: these preliminary results merit replication in a larger primary care-based trial with a longer continuous intervention and followup period. key words: obesity, sleep, weight loss, primary care, health behavior e logue et al. am j health behav. 2012;36(3):319-334 doi: http://dx.doi.org/10.5993/ajhb.36.3.4

Eligibility criteria:
inclusion criteria: * bmi 25 to 39.9 * ages 18 to 84 * pcp permission * patient in family medicine center with an encounter in the last six months exclusion criteria: * various obesity and sleep related disorders

Keywords: obesity primary care
immunosuppression and diet: the role of inflammation in the adipose tissue remodeling

Conditions: Obesity; Liver Transplantation

Summary: the main goal of this project is to evaluate the effect of immunosuppression in the weight loss and in the metabolic status of patients after liver transplantation. it is also the purpose of this project to investigate why patients become overweight and obese after liver transplantation.

overweight and obese post-liver transplantation patients will receive a diet to promote weight loss during 6 months. the control group (overweight and obese subjects) will be submitted to the same protocol: the participants will be interviewed at baseline and after 30, 60, 90 and 180 days from baseline. the following measures will be assessed: body composition (fat body% and free fat body%), anthropometric measures (height, weight, body mass index, waist circumference and abdominal circumference), blood pressure, basal metabolic rate, behavioral symptoms and peripheral biomarkers in the serum. behavioral symptoms will be assessed using the following self-reported questionnaires: beck depression inventory (depression symptoms), beck anxiety inventory (anxiety symptoms), medical outcomes study 36 - item short - form health survey (quality of life) and perceived stress scale (stress). enrolled participants will receive a restrictive diet calculated based on individual requirements aiming the loss of around 5%-10% of weight/ 6 months of intervention.

Eligibility criteria:
inclusion criteria: * control group: women/men aged 18-60 years old; body mass index 25-40 kg/m2. * immunossuppressed patients: women/men aged 18-60 years old; body mass index 25-40 kg/m2; liver transplantation between 1-3 years from the time of recruitment. exclusion criteria: * control group: pregnant or lactating womenbuse of alcohol or drugs * endocrine disease * use of hormones which interferes in the weight * use of insulin or anti-inflammatory, and antidepressants drugs * use of drugs to loss weight * immunosuppressed patients * subjects in another weight loss program * subjects submitted to bariatric surgery * immunossuppressed patients: pregnant or lactating women * abuse of alcohol or drugs * endocrine disease * use of hormones which interferes in the weight * use of insulin or antidepressants drugs * use of drugs to loss weight * subjects in another weight loss program * subjects submitted to bariatric surgery, re-transplanted patients, hepatic insufficiency.

Keywords: obesity liver transplantation weight loss diet immunosuppression