Kornimate/medical-research-clean huggingface dataset:
evaluation of cardiac function with cardio-respiratory synchronized mri

Conditions: Heart Disease

Summary: the purpose of this investigation is to evaluate newer methods of performing cardiovascular mri (cmr) that will provide new kinds of information related to the interplay between the cardiac and the respiratory cycles, such as the interaction between the left ventricle and the right ventricle during respiration . the primary statistical objective is to provide preliminary indications of the relative utility of the investigational imaging software in terms of image quality and suitability for routine clinical use. image quality will be expressed in terms of signal-to-noise ratios (snr), contrast-to-noise ratios (cnr) and subjective likert-type qualitative assessments independently provided by each of multiple blinded readers for each image. suitability for routine use will be assessed in terms of imaging time and a binary indicator of whether, in the opinion of the investigator, adverse procedural complications (not expected) were encountered during a given imaging session.


Eligibility criteria:
inclusion criteria: * subjects will be selected as they are scheduled for clinical mr examinations. * subjects will be selected on the basis of their willingness and ability to participate, on their comprehension of the informed consent document, on their likelihood of completing the study, and on the clinical appropriateness of the investigational technique for a given patient. exclusion criteria: * electrical implants such as cardiac pacemakers or perfusion pumps * ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants * ferromagnetic objects such as jewelry or metal clips in clothing * pre-existing medical conditions including a likelihood of developing seizures or claustrophobic reactions, and any greater than normal potential for cardiac arrest.

Keywords: magnetic resonance imaging (mri)
comparing two prophylactic antibiotic protocols in women with term prolonged pre-labor rupture of membrane and preterm labor

Conditions: Preterm Labor With Preterm Delivery; Premature Rupture of Membranes Prolonged

Summary: this randomized prospective trial aimed to compare 2 prophylactic antibiotic regiment (ampicillin alone versus ampicillin plus gentamycin) in term prolonged pre-labor rupture of membrane and in preterm deliveries and examine related obstetrical outcome and infectious morbidity

maternal peripartum fever is a common complication of pregnancy and postpartum period associated with potentially serious obstetrical outcomes and infectious morbidity. peripartum infections includes intrapartum intraamniotic infection (iai) and postpartum endometritis. both are caused by polymicrobial bacterial infection. increased latency period from rupture of membranes (rom) until delivery is a common risk factor. another risk factor is pre-term delivery. this randomized prospective trial aimed to compare 2 prophylactic antibiotic regiment (ampicillin alone versus ampicillin plus gentamycin) in term prolonged pre-labor rupture of membrane and in preterm deliveries and examine related obstetrical outcome and infectious morbidity. primary outcome-peripartum infections- chorioamnionitis, endometritis and surgical site infection secondary outcome- obstetrical outcome- mode of delivery, apgar score, cord blood ph, peripartum fever, maternal length of admission, postpartum maternal antibiotic treatment, surface swab cultures were obtained from the placenta, amnion and umbilical cord (birth cultures) and uterine swab cultures, maternal blood culture, placental histologic evaluation neonatal outcomes-nicu admission, length of admission, neonatal morbidity-ventilation support, early neonatal sepsis

Eligibility criteria:
inclusion criteria: maternal age \> 18 years singleton pregnancy vertex presentation prolonged \>18 h prom or preterm delivery - exclusion criteria: * gbs carrier * preterm premature rupture of membrane for conservative treatment * intra-uterine fetal death fetal major anomaly * drug allergy for the antibiotic in use in this study * women receiving antibiotic treatment for other infection such as urinary tract infection

Keywords: prolonged term prom pre-term labor prophylactic antibiotic peripartum infection bacterial distribution
tdcs to treat hemiplegic shoulder pain

Conditions: Stroke

Summary: the purpose of the study is to investigate the possibility of treating hemiplegic shoulder pain (hsp) using transcranial direct current stimulation (tdcs) in patients following stroke. the secondary aims are to see if this treatment affects motor function of the upper limb, to asses the different types of hsp and whether there is any correlation to the location and extent of the stroke.

hemiplegic shoulder pain (hsp) is a common entity following stroke. it's prevalence varies between studies, probably because it includes many etiologies and there is no one way of diagnosis. hsp delays rehabilitation, elongates hospitalization time and reduces quality of life. currently there is no one reccomended treatment for hsp. weak transcranial direct current stimulation (tdcs) induces persisting excitability changes in the human motor cortex. this effect depends on the stimulation polarity and is specific to the site of stimulation. interacting with cortical activity, by means of cortical stimulation, can improve the rehabilitation potential of neurologic patients. in this respect, preliminary evidence suggests that cortical stimulation may play a role in treating aphasia, unilateral neglect, and chronic pain disorders. in this tdcs study the investigator uses one anode and one cathode electrode placed over the scalp to modulate a particular area of the central nervous system (cns). the stimulation is administered via the neuroconn dc.stimulator. the dc-stimulator is a micro-processor-controlled constant current source. the dcstimulator is a ce-certified medical device for conducting non-invasive transcranial direct current stimulation (tdcs) on people.electrode positioning is determined according to the international eeg 10-20 system.

Eligibility criteria:
inclusion criteria: * patients hospitalized in the department of neurologic rehabilitation of loewenstein rehabilitation center after first clinical stroke. * able to understand and comply with basic instructions * signed an informed consent form * hebrew speaking exclusion criteria: * shoulder pain predating the stroke * epilepsy

Keywords: hemiplegic shoulder pain transcranial direct current stimulation stroke
compartmental inflammation in mechanically ventilated patients with covid-19

Conditions: COVID-19; Respiratory Failure

Summary: the aim of the present study is to examine the inflammatory response in the pulmonary compartment and blood of critically ill patients admitted to the icu with covid-19.

the mechanisms of the ards-like respiratory failure observed in patients with covid-19 are currently unknown, but may be related to a distinct local immune response within the lung. in the present study, we will examine the cellular and humoral pulmonary immune response in mechanically ventilated patients admitted to the icu with covid-19 by examining immune cell profiles, cytokine patterns, and the complement pathway in bronchoalveolar lavage fluid, and relate it to the concomitant systemic inflammatory response. we will examine the patients on day 1-3 and 7-9 after icu admission.

Eligibility criteria:
inclusion criteria: * age \> 18y * mechanical ventilation * verified covid-19 (throat swab or tracheal aspirate positive for sars-cov-2) * ards according to the berlin definition exclusion criteria: * untreated malignant tachycardia or bradycardia * suspected or verified intracranial hypertension (icp \> 15 mmhg) * unilateral lung ventilation * severe non-correctable coagulopathy
telmisartan tab hypertension

Conditions: Hypertension

Summary: to assess the efficacy of telmisartan in hypertensive patients with high cardiovascular risk

study design:

Eligibility criteria:
inclusion criteria: hypertensive patients with bp. 140/90mmhgand high and very high cardiovascular risk according to the esh/esc guidelines 2007 and in whom the prescriber has taken the decision to start treatment with telmisartan 40 or 80 mg, with or without hctz 12.5 mg or 25 mg, in the usual way and in line with the smpc and reimbursement criteria exclusion criteria: contra-indications as in the summary of product characteristics
rce with fmt in the treatment of childhood constipation

Conditions: Fecal Microbiota Transplantation; Constipation - Functional

Summary: constipation is the most common complaint in childhood gastrointestinal disease, affecting an estimated 20% of the global children.the treatment strategies consist of diet control, behavioral intervention and oral and sometimes rectal laxatives. given higher success rate and fewer side effects, the laxative peg3350 has been considered the first choice in childhood constipation.however, effectiveness of peg 3350 laxative is not lasting, and the use of peg increases the risk of fecal incontinence. additional treatment interventions are still necessary.enema can act directly on the rectum and distal colon to quickly relieve symptoms of fecal impaction which is considered one of main source of intractable constipation. children with fecal impaction who received enema had fewer fecal incontinence and diarrhea than children who received peg. there have been lots of evidence that enema is effective in fecal impaction in children with functional constipation.but there are still cases of recurrences noted after enema. fecal bacteria transplantation (fmt) is a new treatment method emerging in recent years, which is widely used in the treatment of functional gastrointestinal diseases. fmt has been proved to play a very prominent role in correcting intestinal flora disorders. by transplanting exogenous flora into the intestinal tract of patients, fmt can inhibit bacterial reproduction, regulate intestinal environment and cascade the body immunity, so as to achieve the therapeutic effect of disease. retrograde colonic enema with fmt, an new method, provides the possibility for the treatment of childhood constipation. however, there is still a lack of evidence-based support for the treatment of childhood constipation by retrograde colonic enema with fmt. therefore, we designed a randomized, controlled, double-blind clinical trial to confirm the efficacy and safety of retrograde colonic enema with fmt in the treatment of childhood constipation.


Eligibility criteria:
inclusion criteria: * 4-14 years old; * roman iv criteria for childhood constipation; * after a course of peg and a course of chinese medicine treatment was ineffective; * barium enema showing fecal impaction. exclusion criteria: * congenital and/or acquired intestinal diseases, such as congenital megacolon, intestinal stenosis, polyps, crohn's disease, tuberculosis, inflammation, and tumors; * anorectal diseases, such as anal atresia, fistula, abscess, and tumor; * neurological diseases, such as brain and spinal cord diseases; * genetic metabolic diseases; * psychosocial and behavioral diseases; * other systemic diseases; * refused to participate in.
a study of telaprevir (vx-950), pegasys and copegus in hepatitis c (prove3)

Conditions: Hepatitis C

Summary: the prove3 trial is a partially double blinded, randomized, phase 2 research study of an investigational drug, telaprevir (vx-950) or placebo, with pegylated interferon alfa 2a (peg-ifn-alfa-2a, pegasys®), and ribavirin (rbv, copegus®) in people with genotype 1 hepatitis c who have not achieved a sustained viral response (svr) with a previous treatment of interferon therapy.


Eligibility criteria:
inclusion criteria: * males and females between 18 and 70 years old * detectable plasma hepatitis c virus (hcv) ribonucleic acid (rna) greater than or equal to (\>=) 10,000 international units per milliliter (iu/ml) * must have chronic hepatitis c (genotype 1) and have already received at least one prior course of pegylated interferon alfa 2a with ribavirin * cannot also be infected with human immunodeficiency virus or hepatitis b * must be judged to be in general good health and able to receive pegasys® and copegus® * no drug or alcohol abuse in the last year * must agree to use two effective methods of birth control during the study and for 6 months after you stop taking study medication. one of the methods needs to be a 'barrier' method (condom or diaphragm) * if you are a woman, you cannot be in this study if you are pregnant or nursing exclusion criteria: * participation in any clinical trial of a hcv protease inhibitor of any duration * prior response to therapy and failure to achieve svr which was due to treatment non-compliance * any other cause of significant liver disease in addition to hepatitis c; this may include but is not limited to, hepatitis b, drug or alcohol-related cirrhosis, autoimmune hepatitis, hemochromatosis, wilson's disease, nonalcoholic steatohepatitis, or primary biliary cirrhosis * diagnosed or suspected hepatocellular carcinoma * history of or current evidence of decompensated liver disease * participation in any clinical trial of an investigational drug within 90 days before drug administration or participation in more than 2 drug studies in the last 12 months (exclusive of the current study)

Keywords: genotype 1
abcb1/p-glycoprotein expression as biologic stratification factor for patients with non metastatic osteosarcoma

Conditions: Osteosarcoma

Summary: this is a phase ii multicentre, uncontrolled trial including patients ≤ 40 years with non-metastatic extremity high-grade osteosarcoma stratified according to p-glicoprotein expression

the main objective of the study is to evaluate the impact on event-free survival (efs) of a multi-drug chemotherapy approach and mifamurtide treatment in patients with non-metastatic osteosarcoma of the extremities according to the expression of abcb1/p-glycoprotein

Eligibility criteria:
inclusion criteria: * histology confirmed diagnosis of extremities high grade osteosarcoma * age ≤ 40 years * localized disease or presence of skip metastasis * hepatic, renal and bone marrow normal function * lvef \> 50% * no previous surgery and/ or chemotheraputic osteosarcoma treatments, * no more than 4 weeks interval between histological diagnosis and start of chemotherapy * informed consent to the study participation obtained. exclusion criteria: * presence of metastases other than skip metastases * periosteal osteosarcoma, parostal osteosarcoma, secondary osteosarcoma, * medical contra-indication to the drugs foreseen in the protocol, * subject is pregnant or breast feeding * mental or social conditions that can compromise a correct adherence to the protocol and its procedures

Keywords: non metastatic extremities high grade osteosarcoma
intra-arrest therapeutic hypothermia in prehospital cardiac arrest

Conditions: Cardiac Arrest

Summary: the aim is to precise the place of therapeutic hypothermia induced before return of spontaneous circulation (rosc) in pre hospital cardiac arrest. if we find a benefit in terms of biomarkers in inducing in early hypothermia compared to hypothermia induced only after arrival at the hospital, there will be arguments to develop a higher scale study, allowing to prove benefits in terms of survival and neurological status.

principal aim : prove the efficiency of early therapeutic hypothermia induced during ischemia in pre hospital cardiac arrest by a reduction of brain damage biomarkers. secondary aim: prove the efficiency of early therapeutic induced hypothermia in the reduction of pro-inflammatory cytokines secretion. determine the number of rosc, patients survival, neurological status 48 hours after cardiac arrest (gcs) and when leaving the hospital, impact following initial cardiac rhythm and the cooling rate of early therapeutic induced hypothermia.

Eligibility criteria:
inclusion criteria: * pre hospital cardiac arrest exclusion criteria: * under 18 years old * pregnancy or breastfeeding women * patient under guardianship. * not beneficing a social health care system. * cardiac arrest of traumatic origin * patients with an initial body temperature under 34° c * cardiac arrests for which resuscitation maneuvers seem unjustified (dnr criteria)

Keywords: hypothermia cardiac arrest biomarkers pre hospital cardiac arrest
emergency department triage of patients with acute chest pain based on the esc 0/1-hour algorithm (presc1se-mi)

Conditions: Acute Chest Pain; NSTEMI - Non-ST Segment Elevation MI

Summary: the presc1se-mi study compares two algorithms for triage of patients presenting with chest pain and symptoms of heart attack (myocardial infarction) to the emergency department. both algorithms are recommended by the european society of cardiology: the 0/3-hour algorithm and the 0/1-hour algorithm. currently, most emergency departments worldwide use the 0/3-hour troponin algorithm. cardiac troponin (ctn) is a heart-specific biomarker which indicates damage of the heart muscle and which increases after a heart attack. in the 0/3-hour algorithm, the amount of troponin in the bloodstream is measured with a high-sensitivity assay at admission and 3 hours thereafter. likewise, the 0/1-hour algorithm means that the blood sample in which the troponin is measured is collected at admission and 1 hour later. since recent clinical studies suggest that the 0/1-hour algorithm is superior to the 0/3-hour algorithm, many hospitals consider switching to the 0/1-hour algorithm. the aim of this study is to assess how feasible the time-saving 0/1-hour algorithm would be in reality and whether it provides the same accuracy and safety in the diagnosis of myocardial infarction as the current practice the 0/3-hour algorithm.


Eligibility criteria:
inclusion criteria: * patients aged 18 and above * presentation with acute non-traumatic acute chest pain to the emergency department * suspicion of acute myocardial infarction exclusion criteria: * terminal kidney failure requiring dialysis * cardiac arrest * cardiogenic shock

Keywords: esc 0/1-hour algorithm emergency department chest pain chest discomfort myocardial infarction mi acute myocardial infarction ami acute coronary syndrome acs nstemi non-st-segment elevation myocardial infarction nste-acs non-st-segment elevation acute coronary syndrome unstable angina damaged muscle of the heart cardiac biomarkers cardiac troponin t ctnt cardiac-specific troponin t cardiac troponin i ctni cardiac-specific troponin i amount of troponin in the bloodstream increased troponin level elevated troponin level high troponin level troponin assessment measurement of troponin levels high-sensitive troponin test high-sensitivity troponin t testing high-sensitive troponin t hstnt ctnt-hs high-sensitive troponin i hstni ctni-hs high-sensitivity cardiac troponin assays ed presentation ed admission ed work-up triage emergency department triage emergency room triage emergency hospital rapid rule-out of acute myocardial infarction shorter stay in the emergency department esc 0/3-hour algorithm esc guidelines european guidelines 0/1-hour algorithm 0/3-hour algorithm
effectiveness of different preventive regimens in cariogram parameters and dmf scores of high caries risk patients: a randomized control trial

Conditions: Prevention of Dental Caries

Summary: 66 participants will be divided into three groups according to the tested regimen (a), where (a1) represents participants exposed to fluoride toothpaste, (a2) represents participants exposed to regimen including fluoride toothpaste and chlorhexidine mouthwash and (a3) represents participants exposed to regimen including fluoride toothpaste, chlorhexidine mouthwash and mi fluoride varnish. the study will be carried over a period of one year, assessment of cariogram will be done in two visits: first visit (baseline: t0) and second visit (after 3 months: t2). in addition assessment of dmf scores will be done in four visits: first visit (baseline: t0), second visit (after 3 months: t1), third visit (after 6 months: t2) and final visit (after 12 months: t3) to obtain the required data


Eligibility criteria:
inclusion criteria: * age range 20-50 years * high caries risk patients defined according to cariogram caries risk assessment model * on non-cariogenic diet * high plaque index * systematically healthy * no orthodontic or prosthodontic appliance exclusion criteria: * age range less than 20 or more than 50 years * low or moderate caries risk patients according to cariogram * patients with a compromised medical history * cariogenic diet patient * participants with a history of allergy to any of the drugs or chemicals used in the study * patients on any antibiotics during the past month
electrocoagulation employment during tapp inguinal hernia repair

Conditions: Inguinal Hernia

Summary: laparoscopic tapp (transabdominal preperitoneal) hernia repair presents a minimally invasive surgical procedure, which tends to be a gold standard in a wide range of inguinal hernia operations. postoperative neuralgia is a troublesome complication following tapp, which occurs in 0.2-7% of patients. the most common cause of nerve injury is an inappropriate use of electrocoagulation or dangerous tissue dissection during tapp. however, the association between electrocoagulation employment during tapp and postoperative neuralgia has not been investigated properly until now. the aim of the project is to compare postoperative pain (postoperative neuralgia) in patients undergoing tapp inguinal hernia repair with/without the use of electrocoagulation.

worldwide, more than 20 million patients undergo inguinal hernia repair annually. laparoscopic hernia repair presents a minimally invasive surgical procedure, which tends to be a gold standard for inguinal hernia repair. in comparison with open techniques of hernia repair, tapp approach requires a totally different anatomic point of view. the operating surgeon must understand the basic principles and technical key points of tapp in order to ensure satisfactory surgical outcomes and to prevent the occurrence of complications. postoperative neuralgia presents a troublesome complication following tapp, which occurs in 0.2-7% of patients. neuralgia is caused by intraoperative injury of genitofemoral, ilioinguinal, iliohypogastric or cutaneous femoris lateralis nerves (genitofemoral nerve being is the most often damaged). during tapp, the most frequent causes of neural injury include clip application, inappropriate use of electrocoagulation or dangerous tissue dissection. at present, the employment of modern self-gripping meshes and tissue glues leave the use of electrocoagulation the main risk factor for potential nerve injury. the aim of the proposed project is to evaluate postoperative pain (postoperative neuralgia) in patients undergoing tapp inguinal hernia repair with/without the use of electrocoagulation. the assessment of the pain in the groin region will be performed on the 2nd and 7th postoperative day by means of clinical examination and by fulfilling the visual scale of pain. in patients showing clinical signs of postoperative neuralgia on the 7th postoperative day, clinical examination by an experienced neurologist will be performed.

Eligibility criteria:
inclusion criteria: * age ≥18 years * unilateral inguinal hernia * no previous intraabdominal operations * no history of neurological diseases exclusion criteria: * recurrent inguinal hernia * bilateral inguinal hernia * history of chronic pain syndrome * preoperative asa classification iv-v

Keywords: inguinal hernia repair electrocoagulation postoperative pain thermal injury neuralgia