Kornimate/medical-research-clean huggingface dataset:
effect of coffee consumption on the glycemic index of khalas dates tested in healthy and diabetic subjects

Conditions: Diabetes Mellitus

Summary: the aim of this study was to evaluate the composition of khalas, a very common type of dates used in the uae and to determine the effects of drinking arabic coffee on the results of gi tests in both healthy and diabetic subjects.

background:the consumption of dates along with coffee is a deeply rooted habit in many societies. this study was designed to determine the effect of coffee consumption on the glycemic index of a common variety of dates (khalas) tested in healthy subjects and individuals with type 2 diabetes mellitus. methods:composition analysis was carried out for khalas dates (tamer stage) and the weight of the dates flesh equivalent to 50 g of available carbohydrate was calculated. the study subjects were thirteen healthy volunteers with a mean (± sd) age of 40.2 ± 6.7 years and ten participants with type 2 diabetes mellitus (controlled on lifestyle measures and/or metformin) with a mean hba1c (± sd) of 6.6 ± (0.7 %) and a mean age (± sd) of 40.8 ± 5.7 years. each subject was tested on five separate days with 50 g of glucose (on 3 occasions) and 50 g equivalent of available carbohydrates from the dates without coffee (on one occasion) and with coffee (on another occasion). capillary glucose was measured in the healthy subjects at 0, 15, 30, 45, 60, 90 and 120 min and for the diabetics at 0, 30, 60, 90, 120, 150 and 180 min. the glycemic indices were determined as ratios of the incremental areas under the response curves for the dates alone/with coffee compared to glucose. statistical analyses were performed using student's t-tests.

Eligibility criteria:
inclusion criteria: * required that those in the healthy group were healthy and in the diabetes group that their diabetes was controlled (hba1c ≤8%) on diet with or without metformin exclusion criteria: * morbid obesity (bmi \> 40 kg/m2) * pre diabetes * pregnancy * presence of gastroenterological disorders * alimentary tract surgery * a history of gastroenteritis in the prior six months * any alcohol intake * smoking * taking any medications (except metformin) * poorly controlled diabetes (hba1c \> 8%) and the presence of acute or chronic diseases

Keywords: glycemic index dates diabetes coffee
laser therapy for the prevention of radiodermatitis in head and neck patients

Conditions: Head Cancer; Neck Cancer

Summary: up to 90% of the radiotherapy patients will develop a certain degree of skin reaction at the treated area, also known as radiodermatitis (rd). currently, there is a wide variety of strategies to manage rd, including creams, gels, ointments, wound dressings. however, up to now, there is still no comprehensive, evidence-based consensus for the treatment of rd. low-level laser therapy (lllt) is a promising, non-invasive technique for treating rd. in a recent study conducted in our research group, lllt prevented the aggravation of rd and provided symptomatic relief in patients undergoing radiotherapy for breast cancer after breast-sparing surgery. this was the first prospective study investigating the potential of lllt for rd. in the current study, we want to investigate the efficacy of lllt as a tool for the prevention of radiodermatitis in head and neck cancer patients.


Eligibility criteria:
inclusion criteria: * diagnosis of head and neck squamous cell carcinomas (hnscc) starting in the lip, salivary gland, oral cavity (mouth), nasal cavity (inside the nose), paranasal sinuses, pharynx, or larynx * scheduled for radiotherapy (\>60 gy), chemo-irradiation or bio-radiation either as primary or as post-operative treatment to the head and neck region * age ≥ 18 years * able to comply to the study protocol * able to sign written informed consent * signed written informed consent exclusion criteria: * previous irradiation to the head and/or neck region * metastatic disease * patients with pre-existing skin rash, ulceration or open wound in the treatment area * patients with known allergic and other systemic skin diseases even when not directly affecting irradiated fields * substance abuse patients or patients with medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results as judged by the investigator * any condition that is unstable or could affect the safety of the patient and their compliance in the study as judged by the investigator * patients using high doses of non-steroidal anti-inflammatory drugs
sevoflurane and intravenous anesthesia in hypospadias repair

Conditions: Emergence Delirium; Intravenous Anesthesia; Sevoflurane

Summary: emergence agitation (ea), a phenomenon observed at the time of recovery from general anesthesia (ga).the cause of ed appears to be multifactorial in origin. use of volatile anesthetics, prolonged duration and type of surgery, pain, and rapid emergence are some factors known to increase its incidence

the pathogenesis of postoperative ea is still undefined, but sevoflurane has intrinsic effects that may share in emergence agitation like its different electroencephalogram pattern from halothane, and its degradation to inorganic fluoride ions and compound a which may have a role in the occurrence of ea sevoflurane now is the inhalational anaesthetic agent of choice for pediatrics, as it is non-pungent, with minimal airway irritation characters, and its cardiac adverse effects are minimal like cardiac depression and dysrhythmias. total intravenous anesthesia (tiva) using propofol and fentanyl appears to have a smooth recovery profile

Eligibility criteria:
inclusion criteria: * ages 1 to 8 years * american society of anesthesiologists (asa) physical status i and ii, scheduled for hypospadias repair exclusion criteria: * children with a history of active airway disease, * sleep apnoea, developmental delay, * psychological, * neurological disorder, * cardiovascular abnormality or requirement of post-operative ventilation, * hepatic impairment, and renal insufficiency, with active upper respiratory tract infection
efficacy comparison of topical and intravenous tranexamic acid to reduce the number of blood transfusions in tka

Conditions: Blood Loss

Summary: the main objective is to evaluate the efficacy and safety of topical tranexamic acid (ta) to reduce the blood transfusion rate in total knee arthroplasty. the secondary endpoints are to estimate the visible blood loss at 24 hours after surgery, and invisible blood loss through serial counting of hb/htc. methodology. tranex1 is a phase iii, unicentric, controlled, randomized, double blind clinical trial that compare efficacy and safety of topical ta versus intravenous ta in a multimodal protocol, with no-inferiority criteria(n=79).

the groups will be compared by itt and pp. the non-inferiority would be estimated by comparing the confidence interval using the traditional test, and wilson test.

Eligibility criteria:
inclusion criteria: * adult patients (greater than 18 years old) * patients scheduled for primary unilateral knee arthroplasty * patients for la paz- cantoblanco hospital, madrid, spain exclusion criteria: * patients that refuse to sign the inform consent * allergy to tranexamic acid * major comorbidities: severe ischemic heart disease(class iii and iv of new york heart association); sleep apnea syndrome; severe epoc; renal dysfunction (plasma creatinine\>2mg/dl if mens and \>1.8mg/dl if woman); or hepatic disfunction. * coagulopathy (preoperative platelet count \ 1.4, prolonged ppt(\>1.4 x normal) * history of thromboembolic disease: cva, dvt, pe * blood dyscrasias * retinopathy (disturbances of color vision) * jehovah's witnesses * pregnancy * breastfeeding * been participating or been participated a year ago in another clinical trial

Keywords: total knee arthroplasty, tka, blood loss
motivational interviewing at intake vs intake as usual on client engagement in addiction treatment

Conditions: Substance-Related Disorders; Treatment Adherence

Summary: this k23 study is an effectiveness-implementation hybrid type i design to determine the effectiveness of motivational interviewing at intake (mii), relative to intake-as-usual on client engagement and mechanisms of engagement among adults seeking outpatient addiction treatment. we also will obtain personnel feedback on the feasibility of implementing mii into standard practice by having personnel from the addiction treatment study sites complete implementation climate measures before motivational interviewing (mi) training and post-clinical trial, as well as an individual interview on implementation feasibility post-trial.


Eligibility criteria:
inclusion criteria (client participants): * english-speaking adults seeking treatment for alcohol or other drug use at one of two outpatient addiction treatment programs * provision of signed and dated informed consent form * stated willingness to comply with all study procedures * physically withdrawn from alcohol or other drugs inclusion criteria (personnel participants): * english-speaking adults currently employed at one of the two outpatient addiction treatment programs * provision of electronic informed consent exclusion criteria (client participants): * experiencing severe withdrawal symptoms * actively psychotic, manic, and/or suicidal exclusion criteria (personnel participants): * current position: facility owner or clinical director
the influence of tidal volume to lung strain

Conditions: Critically Ill; Acute Respiratory Distress Syndrome

Summary: measure the lung strain in different tidal volume in adrs patients to find the relationship between tidal volume and lung strain and find the most suitable tidal volume for each patient.

purpose:find the relationship between tidal volume and lung strain in ards patients.then find the most suitable tidal volume for each patient according to the dividing value. methods:measure the lung strain in the tidal volume of 6ml/kg,8ml/kg,10ml/kg and 12ml/kg in each ards patient. hypothesis:with the increase of the tidal volume,the lung strain develops.in the patient with larger lung compliance,the strain of the group of conventional tidal volume is less than 0.27 and there is no obvious difference between the group of small tidal volume.

Eligibility criteria:
inclusion criteria: 1. age:18-85,gender is not limited 2. needing invasive ventilation 3. fit the definition of ards in 2012 "berlin definition" 4. sign the paper of informed consent exclusion criteria: 1. pregnancy and at the end stage of tumour 2. the copd patients 3. less than 24h of mechanical ventilation 4. more than 5 days of mechanical ventilation 5. fio2\>80% 6. presence of air leaks 7. organ dysfunction and hemodynamic instability 8. including in other research

Keywords: acute respiratory distress syndrome lung strain small tidal volume
the effect of the stress ball applied before colocystectomy surgery on patients; surgical fear, anxiety and comfort.

Conditions: Cholecystitis; Stress; Fear; Comfort

Summary: cholecystectomy is the most common major abdominal surgical procedure in western countries. patients may experience fear and anxiety before surgery. stress ball, one of the distraction methods, is an effective method in providing cognitive focus. it is seen that the stress ball method is used to reduce patients' anxiety and pain. squeezing the stress ball during the surgical procedure allows patients to have direct control over the object, increasing their sense of empowerment. in this way, it has a positive effect on anxiety and patient satisfaction without interfering with the surgical procedure. in this study, it is aimed to evaluate the effect of preoperative use of stress ball on patients' fear, stress and comfort in order to determine the effect of stress ball applied before cholecystectomy surgery on patients' surgical fear, stress and comfort. it is thought that the data obtained as a result of the research will provide evidence for the effect of the stress ball, which is a non-pharmacological method used before the procedure, on fear, stress and comfort.

this study was planned to examine the effect of a stress ball applied to patients before laparoscopic cholecystectomy on preoperative anxiety, surgical fear and comfort. patients were given a stress ball before the procedure, and the other group received routine care.

Eligibility criteria:
inclusion criteria: * patients hospitalised in surgical wards and undergoing cholecystectomy, * patients who voluntarily agree to participate in the study will be included. exclusion criteria: * mental retardation and any psychiatric disorder, * alcohol and drug addiction, * dementia, alzheimer's disease etc. affecting cognitive functions, * patients who will undergo other operations other than cholecystectomy surgery.
tonka versus legalon for lowering hepatic enzymes in liver function disorder patients.

Conditions: Liver Function Failure

Summary: the purpose of this study is to evaluate the efficacy tonka on the reduction of alt and ast in moderate to severe liver enzyme elevated patients; compared with silymarin (legalon) after 6 weeks of treatment.


Eligibility criteria:
inclusion criteria: * male and female more than 18 year old. * diagnosed as alcoholic liver disease (ald), or non alcoholic fatty liver disease (nafld), or liver function disorders due to drugs or chemicals. * alt at baseline is in between 150 u/l to 400 u/l * sign the informed consent form exclusion criteria: * hepatitis b or c. * pregnant or lactating women
effects of cocoa supplement in frail elderly subjects (cofre)

Conditions: Sarcopenia; Frail Elderly Syndrome

Summary: the study use a double blind, placebo-controlled design enrolling male and female subjects between 55-90 yo to evaluate the effect of daily consumption of a cocoa beverage on anthropometric, metabolic, oxidative stress, physical performance and quality of life.

the study use a double blind, placebo-controlled design enrolling male and female subjects between 55-90 yo randomly assigned to consumption of a flavonoid rich mixture (flavonoids; f), alkalinized cocoa which eliminates flavonoid content (no flavonoids; nf) or placebo. all beverages had similar physical characteristics and flavor. cocoa beverages were provided in individual sachets containing a dry powder that was reconstituted with water just before consumption. subjects were instructed as above to maintain their usual lifestyle, to limit intake of high caloric foods and flavonoid-containing foods and beverages, and to walk for 30 min/day. to determine the effect of flavonoids, study evaluates anthropometric measures, metabolic parameters as glycemia and a lipid profile (triglycerides, total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol). to evaluate oxidative stress damage as lipid oxidation is measured with the malondialdehyde (mda) assay. protein carbonylation is measured using an assay for detection of carbonyl groups that relies on 2,4-dinitrophenylhydrazine (dnph) as a substrate. the investigators also evaluate interleukin-6 and tumor necrosis factor levels. for physical performance is evaluated the handgrip strength, and mobility assesment with the following test: six-minute walk test, two-minute step, sit-up test and the up \& go test. the investigators also assessed quality of life using the health related qol (eq-5d) questionnaire.

Eligibility criteria:
inclusion criteria: * sex: both * age: 55-90 yo * waist circumference: women \> 80 cm, men \> 90 cm * hdl-c: women \< 50 mg/dl, men \< 40 mg/dl * triglycerides: ≥ 150 mg/dl * glycemia: ≈100 mg/dl * hand strength: women\< 20 kg, men \< 30 kg * up \& go test: \> 10 seconds non-inclusion criteria: * any active infections * malignancies * habitual consumers of antioxidant supplements and cocoa products * use of benzodiazepines or protein supplements

Keywords: flavonoids
intraoperative oct guidance of intraocular surgery ii

Conditions: Macular Holes; Epiretinal Membrane; Diabetic Retinopathy; Retinal Detachment; Retinal Disease; Preretinal Fibrosis; Cataract; Ocular Tumor; Strabismus; Healthy

Summary: the overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes. the investigators believe this technology will enable novel ophthalmic and other microsurgeries not possible due to current limitations in surgical visualization.


Eligibility criteria:
inclusion criteria: 1. healthy controls: healthy eyes without known disease: refractive error including myopia and non-significant cataract is allowed. for selected testing pseudophakia is allowed. 2. surgeons as research subjects: adult (≥18 years old) 3. surgical patients (vitreoretinal surgery): patients undergoing examination under anesthesia or surgery for vitreoretinal diseases 4. surgical patients (anterior segment surgery-glaucoma, ocular surface or strabismus requiring extraocular muscle surgery): include both adults and children. patient undergoing primary, elective minimally invasive glaucoma surgery, ocular surface surgery, or strabismus surgery. exclusion criteria: 1. healthy controls: any ocular disease that restricts the ability to perform oct scanning. conflict of interest with investigators/study personnel, e.g. a student in the lab of an investigator. 2. surgeons as research subjects: no specific exclusion criteria. 3. surgical patients (vitreoretinal surgery): neonates (\< 4 weeks of age) and patients with any ocular disease that restricts the ability to perform oct scanning. 4. surgical patients (anterior segment surgery-corneal and cataract diseases): pediatric patients: the cornea and cataract surgery studies will be restricted to adults (≥ 18 years). children do not have cataract surgery typically by residents and therefore would not fit our study design. similarly pediatric corneal transplants are very rare.

Keywords: microscope integrated optical coherence tomography mioct oct angiography octa
impact of methylation alterations in colon cancer: epidemiology and prognosis

Conditions: Colon Cancer

Summary: we conducted a preliminary study in 2010 using the innovative illumina goldengate (methylation assay) which has enabled us to characterize the level of methylation of 807 potential markers on a series of 200 adenocarcinomas of the colon (c18) and rectosigmoid junction (c19) resected between 1998 and 2001. the results, validated by pyrosequencing, allowed us to establish a panel of 12 markers to assess the level of methylation. the aim of this project is to validate the prognostic value of this panel in a second cohort of patients with adenocarcinomas (stage i to iv) resected between 2002 and 2006 in public and private hospitals (n=685). this study relies on an original collection of surgical specimens of colorectal cancers resected in public and private hospitals among patients resident in the département of côte-d'or and followed by the cancer registry of burgundy. samples obtained from each cancer and from adjacent normal mucosa are stored in liquid nitrogen in the ferdinand cabane biological resources centre(certified s 96900). annotations are collected by the cancer registry staff from multiple sources (pathologists, gastroenterologists, oncologists and radiotherapists). pyrosequencing will be used to quantify the level of methylation. the percentage of methylated allele for each marker on cancerous dna and the ratio of methylated markers to the number of markers analyzed will be determined. the molecular status of msi, braf, kras, and pi3k will be taken into consideration. to study the prognosis, relative and relapse free-survival will be calculated. a multivariate relative survival analysis will be performed to determine independent prognostic factors taking into account the characteristics of patients and tumours and epigenetic and molecular alterations. epigenetic alterations will be described according to age group, sex and subsite. the epigenetic phenotypes will be evaluated according to already known molecular status using logistic regression models.


Eligibility criteria:
inclusion criteria: * adenocarcinomas of the colon (c18) and rectosigmoid junction (c19) * resident in côte-d'or * treated by surgical resection exclusion criteria: * rectal cancer * cancer on crohn's disease and ulcerate colitis * hereditary colon cancer (hnpcc, familial polyposis)
diode laser versus topical corticosteroids in management of oral ulcers in behcet's disease

Conditions: Autoimmune; Behcet Syndrome

Summary: laser therapy is increasingly showing promising results in dental field including oral ulcers.this trial will assess the usefulness of diode laser compared to corticosteroid on oral ulcers of patients diagnosed with behcet's disease.

the enrolled patients will be divided randomly into two groups.one group will receive diode laser (power:100 milli watt,wavelength:980 mmm, delivery system:biostimulation probe) and other group will receive topical corticosteroids(kenacort a orabase: triamcinolone acetonide 0.1% 5 gram adhesive paste - dermaphor) four times daily.

Eligibility criteria:
inclusion criteria: * patients diagnosed with behcet's disease according to international criteria for bd. * patients with active oral ulcers. * patients free from any visible oral lesions other than the oral ulcers of bd. * patients who agreed to take the supplied interventions. * patients who will agree to participate in the study. * patients who will accept to sign the informed consent. exclusion criteria: * patients not physically able to participate in survey or clinical oral examination. * patients with organ or life-threatening disease. * patients with history of a severe or chronic medical condition including tuberculosis, hepatitis and human immunodeficiency virus. * patients under immunosuppressive drugs. * patients with organ transplantation.

Keywords: oral ulcers