Kornimate/medical-research-clean huggingface dataset:
ultrasound monitoring of muscle thickness in premature patients

Conditions: Prematurity

Summary: the goal of this interventional study is to investigate through musculoskeletal ultrasonography how the thickness and muscle trophism in infants aged 28 to 35 weeks undergoing infant massage compared with a group of infants with similar characteristics not subjected to treatment. the main questions it aims to answer are: * to assess by musculoskeletal ultrasound the impact of infant massage on muscle thickness muscle. specifically, changes in muscle thickness and trophism of the quadriceps femoris. * potential effects on spontaneous motility and stature-ponderal growth of infants. in addition, the discomfort and behavioral status of the infant before and after massage will be investigated infant. patients included in the study will be randomized according to a random sequence with a 1:1 ratio into theexperimental group (gs) or the control group (gc). patients in the gs will perform therapy with infant massage in addition to the usual rehabilitation therapies as specified by the program individual habilitative, to which patients in the control group will be subjected exclusively control. infant massage will be performed three times a day (10 minutes per session) until they reach the 35th week of post-conceptional age (35+6) by the two departmental physical therapists (adp and adv). ultrasound will be performed at the time of randomization (t0) and then 1 time per week until the 35th week by two operators (sn and va); at the same time, the circumference of the thigh subjected to ultrasound examination. a 12hz linear ultrasound probe will be used, applied perpendicular to the skin. the infant will be placed supine, with the thigh extended, in a neutral position; excessive compression will be avoided by applying a generous amount of gel. at the midpoint of the thigh, the thickness of the quadriceps muscle will be calculated by measuring the distance between the cortex of the femur and the most superficial muscle fascia. the average of at least 2 measurements will be then calculated. the heckmatt scale will be used to assess the echogenicity of muscle and bone. in addition, at time t0 and at week 35 the following data will be collected: weeks gestational age, weight at birth and at the end of treatment, rectal temperature, blood gas parameters if present.


Eligibility criteria:
inclusion criteria: * gestational age between 28and 35 weeks; * day of life ≥ 7 (to ensure passing the transition phase); * clinically stable infants, either in spontaneous breathing or ventilatory support invasive or noninvasive, with a good ability to regulate states and good stress management. exclusion criteria: * brain pathologies; * dysmorphisms; * clinically unstable patients requiring treatment with inotropes and/or nitric oxide nitric acid and/or drug therapy for closure of the ductus arteriosus of botallo.

Keywords: prematurity infant massage thigh ultrasound muscle ultrasound
frontoparietal priority maps as biomarkers for mtbi

Conditions: TBI (Traumatic Brain Injury); Ocular Motility Disorders

Summary: the purpose of this study is to determine whether there is a quantitative relationship between brain processes seen by a mri and visual deficits caused by mild to moderate traumatic brain injuries (mtbi).

participants with mtbi, as well as healthy control participants, will be invited to participate in up to two study visits. both visits will occur at the university of minnesota's center for magnetic resonance research (cmrr). the first study visit will entail (1) interviews to determine the presence of (and, if present, the severity of) oculomotor difficulties such as convergence insufficiency, and (2) behavioral measures (e.g., visually track a moving dot) to assess skill at allocating spatial attention. for participants who have not before participated in an mri study at the cmrr, a 15-minute scan to acquire research-quality anatomical images of the brain will be acquired at the end of the first visit. a subset of the approximately 88 participants who participate in visit 1 will be invited to participate in visit 2. visit 2 will be dominated by a 90-minute scanning session in the 7 tesla scanner, during which participants will perform a 10-minute spatial attention task and a 10-minute eye movement task, and high-resolution diffusion tensor imaging data will be acquired while participants enjoy the movie of their choice in the scanner.

Eligibility criteria:
inclusion criteria: * normal or corrected to normal visual acuity * no previously documented mtbi (target: 16 out of 88 participants invited for visit 1) * previously documented mtbi (target: 72 out of 88 participants invited for visit 1) * vision impairment (target: 48 out of 88 participants invited for visit 1; expected to be comorbid with mtbi, but non-tbi participants with oculomotor impairments will not be excluded) exclusion criteria: * current use of neuroactive drugs or medications * presence of neurological disorders (other than mtbi and mild ptsd) * contraindications for mri (metal in the body, claustrophobia, diabetes or other diseases or drugs that affect thermoregulation) * inability to comply with behavioral task instructions
endoscopic scoring system utilization in inflammatory bowel disease

Conditions: Inflammatory Bowel Diseases

Summary: inflammatory bowel diseases comprise two distinctive entities: crohn's disease and ulcerative colitis. during the last decade, endoscopic assessment of inflammation has become relevant since it is a prognostic factor. as a consequence, therapeutic targets now contemplate mucosal healing as part of the goals to be achieved. endoscopic scores for crohn's disease and ulcerative colitis have been developed to objectively assess the mucosal inflammatory activity. although they may have some limitations, these scores have been widely accepted in referral centers, especially since they have been adopted as standard evaluation in inflammatory bowel disease clinical trials . however, their use in the setting of endoscopic practice outside centers with a high volume or with less experience in clinical trials is not known.


Eligibility criteria:
inclusion criteria: * adult patients who underwent colonoscopy for the evaluation of mucosal inflammatory activity * patients with an established diagnosis of either crohn's disease or ulcerative colitis exclusion criteria: * sigmoidoscopies performed in ulcerative colitis for the assessment of mucosal inflammatory activity
effects of ursodeoxycholic acid on graft recovery early after adult liver transplantation

Conditions: Liver Transplantation; Ischemia-reperfusion Injury; Cholestasis

Summary: this study is designed to investigate the possible beneficial effects of udca on liver graft recovery early after adult liver transplantation.


Eligibility criteria:
inclusion criteria: * all liver transplant patients in our center between may 2005 and april 2008 were potentially eligible for enrollment exclusion criteria: * age less than 18 years * treatment with udca within one month before operation * inability to provide written informed consent prior to study entry * non-liver organ(s) failure prior to entry
urine levels of metanephrin and normetanephrin in patients with frequent ventricular premature complex

Conditions: Premature Ventricular Contraction

Summary: enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. catecholamines may increase in patients with pvc. metabolites of catecholamines are metanephrine and normetanephrine. our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.

premature ventricular complex is a very frequent arrhythmia. suggested mechanisms for pvcs are reentry, triggered activity, and enhanced automaticity. enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. catecholamines may increase in patients with pvc. half-lives of catecholamines are very short and rather changeable. therefore, 24 hours urine levels of catecholamines are the more sensitive than plasma levels. metabolites of catecholamines are metanephrine and normetanephrine. our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.

Eligibility criteria:
inclusion criteria: * pvc's rate is more than % 5 in 24 hours rhythm recording exclusion criteria: * ischemic heart disease * hyperthyroidism * patients with low ejection fraction

Keywords: premature pvc
predictive factors of pelvic magnetic resonance in the response of arterial embolization of uterine leiomyoma

Conditions: Exposure to Magnetic Field; Uterine Leiomyoma

Summary: the purpose of this study is to determine predictive factors in the pelvic magnetic resonance in the response of arterial embolization of uterine leiomyoma.

this study followed symptomatic premenopausal women with uterine leiomyoma who underwent uterine artery embolization (uae). treatment was accompanied by magnetic resonance imaging of both the volume of the entire uterus and the leiomyomas one month before and six months after uae. this patients were treated at the uterine leiomyoma sector of the department of obstetrics and gynecology, medicine college of the university of são paulo. in this study, the investigators examined 179 leiomyomas in 50 patients.

Eligibility criteria:
inclusion criteria: * ultrasound diagnosis of uterine leiomyoma * presence of symptoms (menorrhalgia and/or pelvic pain) * indication for uae(the desire to keep the uterus and/or contraindications for surgery). exclusion criteria: * malignant genital neoplasms * pelvic inflammatory disease * allergy to iodinated contrast * coagulopathy, renal failure * vasculitis * pelvic irradiation * pregnancy * subserosal leiomyoma with a pedicle smaller than 50% of diameter of the fibroid.

Keywords: leiomyoma uterine artery embolization magnetic resonance imaging
does the hematopoietic stem cell govern residual inflammatory cardiovascular risk in type 2 diabetes

Conditions: Type 2 Diabetes

Summary: to study the effect of type 2 diabetes (t2d) on vascular wall inflammation and hematopoietic stem cell composition in vivo, and whether these changes can be reversed with glucagon like peptide 1 receptor (glp1r)-agonism.

we will use 68ga-dotatate pet/ct scans, bone marrow aspirations and peripheral blood analyses to determine the effect of type 2 diabetes on vascular wall inflammation, and hematopoietic stem cell composition, and whether these changes can be reversed using high dose semaglutide treatment, up to 2.0mg subcutaneously per week, for a period of six months.

Eligibility criteria:
inclusion criteria: * age \>50 years old * diagnosed with type 2 diabetes * hba1c \>64mmol/mol exclusion criteria: 1. (history of) malignant diseases or any clinically significant medical condition that could interfere with the conduct of the study in the opinion of the investigator. 2. chronic or recent infections and/or clinical signs of infection and/or a plasma c-reactive protein above 10ng/ml 3. auto-immune diseases (including type 1 diabetes) 4. recent or chronic immunosuppressant or antibiotic usage 5. use of any glp1r-agonist at baseline or prior intolerance to use of glp1r-agonists. 6. inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study. 7. uncontrolled hypertension (systolic blood pressure \> 180mmhg, diastolic blood pressure \> 100mmhg) 8. uncontrolled chronic inflammatory conditions, including gout. 9. women of childbearing age who are not using effective contraceptives. 10. heart failure new york heart association (nyha) class iv at screening visit. 11. active liver disease or hepatic dysfunction, defined as aspartate aminotransferase (asat) or alanine aminotransferase (alat) ≥ 2 times the upper limit of normal (uln) at screening visit. 12. pancreatitis in medical history.

Keywords: diabetes mellitus dotatate bone marrow semaglutide vascular inflammation glp1
snuff use, smoking, periodontitis and mortality: 30-year cohort study from sweden

Conditions: Tobacco Use; Periodontitis

Summary: smoking and dual using associated with poor periodontal health.

aim: to investigate how snuff use, smoking and risk behaviour affect periodontal health and mortality in a swedish cohort, hypothesizing that they indeed have a poor impact and increase the risk of death. material and methods: study cohort of 1080 subjects aged 31 to 40 years (528 men and 552 women) from stockholm area was clinically examined in 1985 and followed for mortality until 2015. associations between periodontal health parameters, snuff use, smoking and age of death were analysed by classifying all subjects into four groups: "dual-users" (current snuffers and current smokers); "pure snuffers" (current non-smoking snuffers); "pure smokers" (current non-snuffing smokers) and "non-users" (non-snuffers, non-smokers). spss was used for analyses.

Eligibility criteria:
inclusion criteria: * in 1985-1986 a sample was selected from the registry file of all inhabitants of the stockholm area, of people born on the 20th of any month from 1945 to 1954.the sample comprised 3200 people. they were informed about the purpose of the study and called for clinical investigation. 1681 (52.5%) individuals, 840 men and 841 women, participated in the study. subjects had different socio-economic and health backgrounds. exclusion criteria: * other people. any disease was not an exclusion criteria.

Keywords: mortality oral hygiene periodontitis smokeless tobacco tobacco
children's bilateral cochlear implantation in finland

Conditions: Deafness; Hearing Loss

Summary: the purpose of this study is to evaluate short and long term outcomes (benefits and side-effects) of bilateral cochlear implantation and bilateral hearing aid rehabilitation in finnish children.


Eligibility criteria:
inclusion criteria: * congenital severe or profound bilateral hearing impairment * no functional benefit from conventional hearing aids (minimum 3 months trial) * radiologically (ct,mri) patent inner ears and normal central auditory pathways * family is motivated for rehabilitation programme and gives a written consent * finnish or swedish as the primary language in the home exclusion criteria: * a child has an additional anomaly or disability that may affect to his/her functional or neurological development * inner ear anomaly * mother's pregnancy duration less than 32 weeks

Keywords: cochlear implantation hearing aid
study of the effects of iron levels on the lungs at high altitude

Conditions: Pulmonary Hypertension; Mountain Sickness

Summary: the study hypothesis is that body iron levels are important in determining the increase in lung blood pressure that occurs in response to low oxygen levels. the purpose of this study is to determine whether this is true at high altitude, where oxygen levels are low.

pulmonary hypertensive disorders frequently complicate hypoxic lung disease and worsen patient survival. hypoxia-induced pulmonary hypertension is also a major cause of morbidity at high altitude. hypoxia causes pulmonary hypertension through hypoxic pulmonary vasoconstriction and vascular remodelling. these processes are thought to be regulated at least in part by the hypoxia-inducible factor (hif) family of transcription factors, which coordinate intracellular responses to hypoxia throughout the body. hif is regulated through a cellular degradation process that requires iron as an obligate cofactor. in cultured cells hif degradation is inhibited by reduction in iron (by chelation with desferrioxamine) and potentiated by iron supplementation. in humans, we have recently shown that, in laboratory experiments lasting 8 hours, acute iron supplementation blunts the pulmonary vascular response to hypoxia, while acute iron chelation with desferrioxamine enhances the response. this suggests that iron may also affect the pulmonary artery pressure response to hypoxia over longer time periods. the purpose of this study is to investigate this link between iron and the pulmonary artery pressure response to hypoxia, through a study conducted at high altitude allowing concurrent exposure of larger numbers of participants to environmental hypoxia. we wish to explore the extent and the time-course of the effect of iron on pulmonary artery pressure. cerro de pascu (4,340 m) in peru provides the unique ability to make rapid transitions from sea level to high altitude (6-8 hours by road), together with the requisite research facilities. also, one part of this study involves recruitment of patients with chronic mountain sickness, of whom there are many living in cerro de pasco.

Eligibility criteria:
slr arm inclusion criteria: * sea level natives of lowland ancestry * generally in good health * detectable tricuspid regurgitation on echocardiography exclusion criteria: * any significant medical problem * known susceptibility to high altitude pulmonary or cerebral oedema * taking medications or iron supplements cms arm inclusion criteria: * diagnosis of chronic mountain sickness * no recent venesection therapy (within 1 year) * detectable tricuspid regurgitation on echocardiography exclusion criteria: * any other significant medical problem

Keywords: hypoxia iron hypoxia-inducible factor 1 chronic mountain sickness
teaching medical students how to suture: standard simulation vs in situ

Conditions: Sutured Laceration; Laceration

Summary: the purpose of this project is to compare in situ simulation with standard lab simulation. to do this, 30 pre-clinical medical students will be randomized into the lab or er and taught how to suture a simple laceration. to do this, a synthesized 'skin' will be placed over a volunteer's arm and will have an incision of a predetermined length.

for this study, 30 first and second year students will be equally randomized to either a standard simulation lab or the er department to learn the skill of suturing. these students will not have any knowledge of suturing prior to this study. each group will have 15 students. each student will be given access to the same suturing learning video. they will each attempt 15 sutures on a lab generated skin placed over a volunteer's arm. each incision length will be predetermined and of the same length. the student will have the opportunity to re-watch the video in between each suture attempt. the volunteer will record the student's number of attempts and whether or not they had to review the video. the idea behind this, is that students should began to plateau with their learning after about 8-9 attempts and most will no longer require the video beyond that.after the 15 attempts, the student will immediately practice 6 sutures on a second skin over the volunteer's arm, again of a predetermined incision length. at this point the students will only be allowed to practice the suturing skill and will not have access to the learning video. at this point, the student's hands will be video recorded to assess the accuracy of the skill.one week after the learning session, regardless of the environment they initially learned in, the student will be brought to the er and again allowed to practice 6 sutures on a simulated skin placed over a volunteer's arm. the incision will be the same length as the incision in the previous practice session. again, the student's hands will be video recorded while practicing the 6 sutures.afterward, the student will be given a questionnaire regarding which environment they practiced in and how prepared they felt to practice in the insitu environment without learning aids.

Eligibility criteria:
inclusion criteria: * pre clinical medical students (year one or two) exclusion criteria: * medical students not in first or second year training * extensive knowledge or background with suturing

Keywords: simulation medical students in situ simulation
assessment of in vivo skeletal muscle viscoelasticity (arfi imaging) with aging and cancer

Conditions: Sarcopenia

Summary: sarcopenia is known to be associated with loss in muscle mass that results from a reduced number of muscle fibres, an atrophy of remaining muscle fibres, and an increased infiltration of non-contractile tissue (collagen, fat). accentuated by cancer and treatments, sarcopenia impairs muscle function resulting in a higher risk of physical disability and death. the commonly used test for sarcopenia screening consists in a dexa (dual energy x-ray absorptiometry) scan. however, this test can't provide structural muscle information. in contrast, the mechanical properties of muscle tissue can be explored using an acoustic radiation force impulse (arfi). the question remains whether muscle sonoelastography using arfi imaging could be helpful for sarcopenia screening. for this, volunteers will be recruited in three groups: ≤ 30 years (gr a) and ≥ 70years, both without any serious chronic disease, and patients ≥ 70 years presenting curative cares for cancer (gr c). the volunteers belonging to the groups a and b will be followed during one day. the patients included in the group c will be followed during 6 months. for this latter group; the first visit (t0) will take place before treatment and the second visit will take place 6 months later (t6months) volunteers will have clinical examinations (weight, stature, bmi, performance status/ ecog) and will be evaluated on their nutritional status (mna-sf, 24h dietary recall) and physical capacities (ipaq, sppb, lower limb muscle strength, 6-min walk test, qlq-c30 items relative to the fatigue symptom).


Eligibility criteria:
inclusion criteria: * men or women 18 years old or more, * able to understand the protocol and to give their written consent, * health insurance. specific inclusion criteria: * group a: volunteers 18 to 30 yrs; without any pathology, * group b: volunteers ≥ 70 yrs; without any pathology, * group c: performance status (ecog) \< 4; patients included in capadoge study presenting curative cares for cancer by chemotherapy and/ or surgery and/or hormonotherapy and/or radiotherapy. exclusion criteria: * intense activity in 7 preceding days, * functional dependency, * under a legal protection. specific non-inclusion criteria: * groups a \& b: serious chronic disease, * group c: palliative care.

Keywords: sarcopenia arfi dexa cancer