Kornimate/medical-research-clean huggingface dataset:
effect of atracurium and rocuronium on the state and response entropy during isoflurane anesthesia

Conditions: Entropy Device and How Will Muscle Relaxants Affect it

Summary: many studies have explored the effects of inhalation anesthetics, intravenous anesthetics, and muscle relaxants on spectral entropy, but most did not monitor the degree of neuromuscular block. in addition, they do not explore the effects of different degrees of neuromuscular blockade on spectral entropy under different concentrations of isoflurane inhalation. therefore, the present study will evaluate different levels of mac to quantify the isoflurane concentration, as well as different degrees of neuromuscular blockade

the study will include 40 patients fulfilling the inclusion criteria. they will be randomized into 2 equal groups by a computer generated random numbers table, each consisting of 20 patients, namely group a and group r. * group a: patients will receive atracurium. * group r: patients will receive rocuronium. no premedication will be given. after the patients enter the operating room, a venous cannula will be inserted into a large peripheral vein. data from routine monitoring, including non-invasive arterial blood pressure, oxygen saturation, and end-tidal oxygen concentration (eto2) and end-tidal carbon dioxide concentration (etco2) will be collected. neuromuscular blockade will be continuously assessed by acceleromyography using the train-of-four-watch sx system (made in ireland), starting when the patients will be unconscious. re and se will be monitored using a datex ohmeda entropy module (m-entropy) and the entropy sensor system (made in finland). baseline re and se will be recorded. anesthesia will be induced by propofol (dose 2-3 mg/kg) and fentanyl as analgesia (dose 1-2 mg/kg). tracheal intubation will be facilitated with rocuronium (dose 0.6 mg/kg) /atracurium (dose 0.5 mg/kg) after an acceleromyography count of 0. anesthesia will be maintained with isoflurane in an air-o2 mixture (fio2 0.6, 2 l/min). mechanical ventilation will be maintained at a tidal volume of 5-7 ml/kg. ventilator frequency will be adjusted for maintenance of an etco2 of 35-40 mmhg. after equilibrium for 30 minutes se, re and the difference between them will be recorded at mac 0.8 and mac 1 at two levels of muscle relaxation assessed by tof value of 50% and 100%. rocuronium (dose 0.01-0.012 mg/kg/min ) /atracurium (dose 0.005-0.01 mg/kg/min) will be administered as a continuous iv infusion adjusted until 50% and 100% depression of t1 ( first twitch by acceleromyography) will be observed. the entire experiment ended before the start of surgery.

Eligibility criteria:
inclusion criteria: 1. patients american society of anesthesiologists physical status (asa) i to ii. 2. male patients (to avoid bias between gender). 3. age between 20-50 years exclusion criteria: * a. patients receiving any neuropsychiatric medications. b. patients undergoing neurosurgical operation. c. drug addiction. d. body mass index (bmi) more than or equal to 40.

Keywords: entropy, atracurium, rocuronium
wt1 peptid vaccination in carcinomas

Conditions: WT1 Expressing Carcinoma

Summary: in this trial hla-a2+ patients with wt1 expressing carcinomas are vaccinated with a peptide from the leukemia associated antigen wt1 together with immunological adjuvants klh as t-helper protein and gm-csf


Eligibility criteria:
inclusion criteria: * metastatic cancer, no standard treatment option * resected cancer with minimal residual disease, no standard treatment option * wt-1 expression * hla-a2 exclusion criteria: * concurrent chemotherapy
the safety and immune response to influenza vaccination in pregnant women

Conditions: Influenza

Summary: the purpose of this study is to evaluate the antibody response to the influenza vaccine (adimflu-s), as measured by hemagglutination inhibition (hai) at 4 weeks post immunization in pregnant women in compliance with the requirements of the current european union (eu) recommendations for the evaluation of the immunogenicity for a new formulation of a licensed flu vaccine (cpmp/bwp/214/96). besides, the vaccine safety will also be evaluated.


Eligibility criteria:
inclusion criteria: 1. pregnant female aged ≥ 18 years old. 2. subject is pregnant for at least 3 months, inclusive. 3. subject is willing and able to adhere to visit schedules and all study requirements. 4. subject has read and signed the study-specific informed consent. exclusion criteria: 1. subject with previous complicated pregnancy or preterm delivery, spontaneous or medical abortion; 2. subject with history or concurrent high risk of dangerous gestation such as gestational diabetes mellitus (gdm), pregnant induced hypertension, or preeclampsia; 3. subject received any influenza vaccine within the previous 6 months; 4. subject has a history of hypersensitivity to eggs or egg protein or similar pharmacological effects to study vaccine; 5. subject or her family has the history of guillain-barré syndrome; 6. subject has current upper respiratory illness (uri), including the common cold or nasal congestion within 72 hours; 7. subject with influenza-like illness as defined by the presence of fever (temperature over 38ºc) and at least two of the following four symptoms: headache, muscle/joint aches and pains (e.g. myalgia/arthralgia), sore throat and cough; 8. subject receive any treatment with an investigational drug or device, or participation in a clinical study, within 3 months before consent; 9. subject has immunodeficiency or is under immunosuppressive treatment. 10. subject received any vaccine within 1 week prior to study vaccination or expected to receive one within 1 week after study vaccination; 11. subject received any blood products, including immunoglobulin, in the past 3 months before consent; 12. subject has underlying condition in the investigators' opinion may interfere with evaluation of the vaccine;

Keywords: influenza vaccination vaccine pregnancy
visual perturbation training to reduce fall risk in people with parkinson's disease

Conditions: Parkinson Disease; Vestibular Disorder; Gait; Falling

Summary: falls during walking are common in people with parkinson's disease (pd). fall risk can be attributed in part to the loss of automaticity in walking and an increased reliance on sensory cues, such as the input from the balance organ. in this project the investigators want to assess the effectiveness of rehabilitation training aiming to improve this vestibular input. the effects of a visual perturbation training in a virtual reality environment will be compared to conventional treadmill training.

fifty participants (50-65 years) with idiopathic pd (hoehn \& yahr scale 2-3) will be randomly assigned to the intervention group receiving four weeks of vpt in a vr environment using the gait real-time analysis interactive lab system (grail) or a control group receiving four weeks of regular treadmill training. primary outcome measures are spatio-temporal outcome parameters of gait and dynamic stability (gait speed, stride time/length, cadence, step-to-step variability, step width variability and trunk sway), and self-reported falls, and will be recorded at all testing phases (pre-test, after baseline, after intervention and after detraining). secondary outcome measures will include assessments of central and peripheral vestibular function (cervical and ocular vestibular evoked myogenic potentials) for correlation with the primary outcome measures. the secondary outcomes will be recorded at pre-testing and directly after the intervention phase.

Eligibility criteria:
inclusion criteria: * idiopathic parkinson's disease * aged between 50-65 years * bilateral symptoms * able to walk unassisted for 20 minutes (hoehn \& yahr stage ii-iii) * stable medication dosage (if any) * no cognitive disablity exclusion criteria: * non-idiopathic parkinson's disease * strong variation in expressed symptoms * inability to walk unassisted for 20 minutes * underwent a medical procedure to treat parkinson symptoms (e.g. duodopa pump, deep brain stimulator) * cognitive disability (score \< 21 on the montreal cognitive assessment) * illness other than parkinson's disease (flu, covid-19) or disabilities that may affect gait or equilibrium * clogged ear(s) * regular fainting episodes * weight over 120 kg * participation in other clinical studies

Keywords: virtual reality
reeducation of chronic achilles tendinopathy by wearing shoes inclined versus reeducation by kinesitherapy

Conditions: Tendinopathy; Rupture of Achilles Tendon; Chronic Disease

Summary: the purpose of the study is to compare the treatment by wearing shoes inclined at kinesitherapy because it is the first treatment offered by primary care physicians in chronic achilles tendinopathy.


Eligibility criteria:
inclusion criteria: * age: 18-75 years * disease: chronic achilles tendinopathy de novo or recurrent confirmed by ultrasound * patients having signed the informed consent for the study participation * patients covered by medical insurance * patients having no behavioral disorders exclusion criteria: * history of rupture of the achilles tendon (= stage 4) * antibiotic treatment tendinotoxique (quinolones, ...) * inability to walk more than 30 minutes per day. * haglund syndrome * treatment of tendinopathy or being older than six months * minors * major trust
somatic comorbidities in psychiatric patients

Conditions: Schizophrenia; Major Depression Disorder; Bipolar Affective Disorder

Summary: prevalence of somatic comorbidities in psychiatric patients hospitalized in psychiatric hospital or treated ambulatory or in daily hospital. comparison of prevalence of somatic comorbidities in psychiatric patients population and the general croatian population.


Eligibility criteria:
inclusion criteria: * treatment in psychiatric hospital exclusion criteria: * acute suicidality * dementia * mental retardation * acute psychosis * intoxication * inability to answer the questionnaire by themselves
a long term follow-up study for subjects who have received q-cells

Conditions: Transverse Myelitis

Summary: this study is an observational study designed to obtain information on the long-term safety, tolerability, and continued activity of q-cells®. the study will follow the participants who previously received q-cells® for 10 years. the goal of this observational study is to learn about the long term effects of q-cells® in people with transverse myelitis. the main objectives the study is to evaluate the safety of patients who have received q-cells®. the secondary goal of the study is to get data about the long-term activity of q-cells® over a period of 10 years. patients will complete exams, lab tests, imaging, and questionnaires to monitor their safety.


Eligibility criteria:
inclusion criteria: 1. subjects must have been administered q-cells® as part of protocol qtm-101 or other treatment protocol. 2. subjects must have the ability to understand the purpose and risks of the study and provide signed and dated informed consent and authorization to collect and use protected health information (phi) in accordance with national and local subject privacy regulations. exclusion criteria: 1. the study is intended to follow all subjects who have received q-cells® without exception.
rct of ef family training for p adhd

Conditions: ADHD

Summary: to explore the effect of executive function family training for preschool children with adhd, providing early social psychological intervention for aiming the core impairments of adhd.

100 preschool children with adhd will be randomly divided into the intervention group and the waiting group. the waiting group received regular clinical intervention, while the intervention group received 12-week training. the intervention program includes executive function training for adhd children and parenting guidance for parents by two therapists respectively, which were carried out in two meeting rooms in xinhua hospital. therapists are psychiatrists with a background in child psychiatry and psychotherapists with training in adhd area. after 12 weeks, the improvement of adhd core symptoms and executive function was compared.

Eligibility criteria:
inclusion criteria: * meet the diagnostic criteria for preschool adhd, based on the the dsm-5 criteria by the attending physician or above; * age 4 months 0 to 5 years 11 months; * total iq is above 80 assessed by wppsi. exclusion criteria: * attention deficit disorders resulting from organic neurological diseases, extensive developmental disorders, mental retardation, childhood schizophrenia, mood disorders, epilepsy, and other organic diseases or other primary mental disorders; * parent or guardian with a serious mental illness, such as schizophrenia, mood disorder (onset), etc., and educational level is lower than junior middle school; * participants who failed to attend more than 80% of the intervention sessions (at least 9 sessions).

Keywords: adhd executive function preschool intervention rct
plyometric work together with the use of ballast weight in lower limbs in the improvement of performance in jumpers

Conditions: Athletes

Summary: introduction. the high jump is a discipline that use the shortening-stretching cycle. plyometric exersices emply an eccentric load followed by concentric contraction. powerinstep is a tool training by means of weigthed weigth whose objective is improving performance in athletes. aim. evaluate efficacy of plyometric training with powerinstep® in lower limbs, in the performance improvement in professional height jumpers from 18 to 40 years old. study design. non-randomized clinical trial, single bind, with follow-up period. methods. 20 athletes will be recruited, that will be randomized to the two study groups: experimental (they carry out a plyometric training programme with powerinstep) and control (won't be made a intervention on the subjects included in this group). the intervention consists of 6 week, with 2 session for week of 15 minutes duration each. the dependent variables will be the height of the jump, the time of flight, the reaction speed and the impulse force, measures though a pressure platform (model t-plate), employing countermovement jump, abalakov and drop jump tests. we will make a descriptive statistical analysis. the shapiro-wilk statistical test will be used to calculate normality. trough t-student test of repeated measures and an anova of repeated measures will be calculated the difference between distinct assessment (preintervention, postintervention and follow-up) and the effect intra and inter subject, respectively. expected results. we want to observe the changes in performance improvement in height jumpers.


Eligibility criteria:
inclusion criteria: * height jumpers * age between 18 and 40 years * currently participate in the competitive field exclusion criteria: * present medical diagnosis of musculoskeletal pathology * who have not had musculoskeletal injuries in the last month * not signed the informed consent document.

Keywords: jump plyometrics training performance powerinstep non-randomized clinical trial
impact of anticipated regret incorporation into patient decision aids

Conditions: Regret

Summary: the purpose of this study is to investigate the impact of incorporating "anticipated regret " into standard patient decision aids. participants in the wharton behavioral lab will be administered a standard patient decision aid and an "anticipated regret" augmented decision aid. participants will complete a computerized survey about their experiences with each version, and their answers will be assessed for potential differences associated with the incorporation of "anticipated regret."

participants will be recruited through the wharton behavioral lab. upon arrival males will be provided with two decision aids focusing on prostate cancer, while females will be provided with two decision aids focusing on early breast cancer. one of these decision aids will be a standard version, and one of these will be the anticipated regret-augmented version. participants will be randomized to which version they receive first to minimize the effect of presentation order. after reviewing the materials, participants will immediately complete a computerized survey at their work stations that will ask them to answer questions based on the materials presented as well as how any hypothetical treatment decisions they would be asked to make would have been influenced by them. because these are healthy subjects participating in a hypothetical decision-making process for sole purpose of research, the intervention can neither be categorized as experimental or as the standard of care.

Eligibility criteria:
inclusion criteria: * healthy females ages 18 years or older exclusion criteria: * under age 18 years
deep brain stimulation (dbs) for the treatment of refractory obsessive-compulsive disorder (ocd)

Conditions: Obsessive-Compulsive Disorder

Summary: deep brain stimulation for treatment resistant deep brain stimulation

subjects will receive bilateral deep brain stimulation to the ventral capsule/ventral striatum. they will receive standard follow-up and device programming over the span of 52 weeks. after that, they will enter a 5 week double blinded crossover phase consisting of 2 weeks of on or off stimulation, separated by 1 week of 'washout', during which stimulation will be off.

Eligibility criteria:
inclusion criteria: 1. female or male patients between age 18-70 2. dsm-v diagnosis of obsessive compulsive disorder (ocd), at least 5-year illness history with a minimum score of 24 on the yale-brown obsessive compulsive scale (y-bocs). 3. sf-36\<40 4. medication-refractoriness as determined by an adequate dose and duration of psychiatric treatments (including psychotherapy and/or pharmacology) as determined by two psychiatrists associated with the study. including specifically: 1. failed adequate trial of two or more medications accepted as first line in the treatment of ocd 2. attempted augmentation, if tolerated, by at least 1 medications known to be first line treatments for ocd 5. an adequate trial of cognitive behavioural therapy 6. ability to provide informed consent and comply with all testing, follow-ups and study appointments and protocols exclusion criteria: 1. any past or current evidence of psychosis or mania (patients with co-morbid depression will not be excluded from the study) 2. active neurologic disease, such as epilepsy 3. alcohol or substance dependence or abuse in the last 6 months, excluding caffeine and nicotine 4. current suicidal ideation 5. any contraindication to mri scanning 6. no contraindication for dbs surgery 7. presence of significant cognitive impairment 8. likely to relocate or move out of the country during the study's duration 9. presence of clinical and/or neurological conditions that may significantly increase the risk of the surgical procedure. 10. currently pregnant (as determined by history and serum hcg) or lactating; for females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation
breast cancer and breast self-examination education

Conditions: Breast Cancer; Breast Self-Examination

Summary: according to a news published by the world health organization (who); more than 2.3 million cases of breast cancer occur each year, making it the most common cancer among adults. in 95% of all countries, breast cancer is the first or second cause of female cancer death. in 2020, 2.3 million women worldwide were diagnosed with breast cancer and 685,000 deaths occurred. in turkey, breast cancer ranks first among the most common cancer types in women, and the number of breast cancer cases in women in 2020 was recorded as 74 638. as a result of this situation, who (2023) published the global breast cancer initiative framework to save 2.5 million lives from breast cancer by 2040. this published framework includes health promotion for early detection, timely diagnosis and comprehensive management of breast cancer. one of the most effective ways to reduce breast cancer mortality and morbidity rate is early diagnosis. it is important to determine early diagnosis and signs and symptoms of cancer before they appear. early diagnosis of breast cancer is possible with breast self-examination (bse), clinical breast examination and mammography. breast self-examination is an important examination method in terms of detecting changes in breast tissue and preventing subsequent complications. it is also an easy-to-apply, cheap and non-invasive method. in turkey, it is recommended that women regularly perform breast self-examination every month after the age of 20, women between the ages of 20 and 40 should have a clinical breast examination every two years, and women between the ages of 40 and 69 should have a clinical breast examination every year and have a mammogram every two years. there are studies showing that fear of breast cancer has a positive and negative impact on early diagnosis behaviors. champion et al. (2004) stated that women with moderate breast cancer fear had a high rate of early detection behavior, whereas low and high fear levels had a negative effect on behavior. in the study conducted by yavan et al. (2010) on 188 women, 2% of the women. they found that 3 of them had regular bse and 78.7% of them had never had a mammography. in addition, 85% of the women included in the study stated that they had a fear of breast cancer due to a family history of breast cancer, being diagnosed with breast cancer, and the presence of risk factors. study results show that fear of breast cancer affects screening results. therefore, aim in the study is; to determine the effect of breast cancer and bse training given to women on breast cancer fear and bse skills.


Eligibility criteria:
inclusion criteria: * able to read and write, * having no history of breast cancer, * no communication barriers, * not pregnant or lactating, * those who are willing and agree to participate in the research. exclusion criteria: * having a mental illness, * those who wish to withdraw from any part of the research.

Keywords: breast self examination breast cancer education fear
effects of different pressure garments on upper extremity sensorimotor functions and quality of life after stroke

Conditions: Cerebral Vascular Accident (CVA)/Stroke

Summary: the study aims to compare the effects of dorsal-double-layered 10% circumferential reduction (dd-10), single-layered 10% circumferential reduction (s-10), and single-layered no circumferential reduction (s-0) pressure garments on sensorimotor functions, including motor control, dexterity, muscle tone, pain, self-perceived upper extremity function, and quality of life among stroke patients during the 8 weeks of application (time 1: baseline, time 2: week 4, time 3: week 8).


Eligibility criteria:
inclusion criteria: * between 18 and 80 years of age * within 1-12 months of ischemic or hemorrhagic stroke * first onset resulting in hemiparesis of a limb with burnnstrom stage of 3, 4 or 5 * modified ashworth scale with scores of less than or equal 2 for elbow, wrist, and hand muscle tone in the affected upper extremity * able to understand instruction exclusion criteria: * serious cardiovascular or respiratory diseases * skin lesions, infections or other skin problems * serious circulatory problems such as deep vein thrombosis * allergies or significant discomfort to pressure garment materials * upper extremity fractures or severe joint problems * severe cognitive impairment with saint louis university mental status (slums) scores equal to or less than 27 (above high school level of education)/25 (below high school level of education)

Keywords: pressure garment quality of life stroke rehabilitation occupational therapy motor activity sensory feedback upper extremity paresis