Kornimate/medical-research-clean huggingface dataset:
ultrasound biomicroscopic analysis of cionni ring and in-the-bag iol implantation for subluxated lenses

Conditions: Lens Subluxation

Summary: to report the ultrasound biomicroscopic findings following cionni ring bag fixation and in-the-bag iol implantation. to assess the relationship of the bag and cionni ring positioning in relation to surrounding ocular structures, in pediatric eyes

cionni ring fixation of the capsular bag in conjunction with placement of an iol has been found to be safe and effective compared with other current alternatives, even given the exceptionally high difficulty levels and complexity of these cases, in both adult and pediatric eyes. one limitation of techniques requiring trans-scleral suturing is that the suture cannot always be passed under adequate visualization, and, once the knot is secured, the exact position of the cionni ring cannot always be accurately localized. analysis of cionni ring position with respect to the iol and iris is important, as faulty placement of the ring or iol can lead to complications which can threaten vision, especially in children with a high predisposition towards postoperative adverse events. unfortunately, pupillary dilatation and slit-lamp examination may not always be adequate to assess the cionni ring or the eyelet position, as it occupies the peripheral section of the capsular bag. ubm has been shown to be accurate and reproducible in examining the haptic position in relation to the sulcus and ciliary body, anterior chamber depth (acd), vitreous incarceration, focal iris abnormalities, angle anatomy, and relationship of the iris to the lens (straight or tilted). this study aims to provide information on ubm findings following cionni ring implantation in pediatric eyes for non-traumatic subluxation of the crystalline lens.

Eligibility criteria:
inclusion criteria: * children less than 18 years of age, * non-traumatic lens subluxation undergoing cionni ring bag fixation with in-the-bag iol implantation exclusion criteria: * traumatic lens subluxation * intraoperative inability to fixate the cionni ring

Keywords: cionni ring ultrasound biomicroscopy
use of brain oxygen tension level and cleaved-tau protein to detect vasospasm after sah

Conditions: Subarachnoid Hemorrhage; Cerebral Vasospasm

Summary: the purpose of this study is to investigate if brain oxygen levels, levels of a specific protein in the cerebrospinal fluid and blood (cleaved-tau protein), and brain blood flow can predict spasm of brain blood vessels after bleeding in the brain from a ruptured aneurysm.

rupture of a cerebral aneurysm causes subarachnoid hemorrhage (sah). blood in the subarachnoid space of the brain can cause irritation of the cerebral blood vessels, leading to constriction of these vessels, a phenomenon known.as vasospasm. cerebral vasospasm can cause stroke and possibly death. of all the patients with sah, approximately 20-40% will suffer from clinical vasospasm and more than 60% of those patients will never get back to their previous functional status. tools to identify early vasospasm and thus early treatment could greatly decrease the morbidity and mortality following sah. cleaved tau protein is a neuronal marker that has been detected in blood and csf of stroke patients early in its time course. since vasospasm can lead to stroke, the purpose of this project is to determine whether increase in cleaved tau protein in blood and/or csf can predict early stroke from vasospasm. changes in brain oxygen tension measured by a brain tissue oxygen monitor and cerebral blood flow measured by ct perfusion will be correlated with cleaved tau protein levels and clinical status. utilizing statistical analysis the levels of cleaved tau protein, brain oxygen and blood flow during hospitalization will be correlated with patient outcome. through this study we hope to identify increase in cleaved tau protein and decrease in cerebral blood flow and oxygenation as predictors of early vasospasm. early detection and treatment of vasospasm could decrease the stroke rate in sah patients and therefore be of great benefit to society.

Eligibility criteria:
inclusion criteria: * patients with subarachnoid hemorrhage * patients with external ventricular drains exclusion criteria: * patients in whom consent is not attainable

Keywords: subarachnoid hemorrhage cerebral vasospasm cleaved-tau protein brain oxygen tension level
study on the safety and tolerability, pharmacokinetics and pharmacodynamics of shr-2004 injection in adult patients with atrial fibrillation

Conditions: Atrial Fibrillation

Summary: this study is an open-label phase ib clinical study with the primary objective of evaluating the safety and tolerability of multiple subcutaneous injections of shr-2004 injection in patients with atrial fibrillation, and the secondary objective is to evaluate its pharmacokinetic (pk), pharmacodynamic (pd) and immunogenicity characteristics.


Eligibility criteria:
inclusion criteria: 1. understand the study procedures and methods, voluntarily participate in this trial, and sign the informed consent form in writing; 2. male or female ≥ 40 years and \< 80 years old； 3. history of atrial fibrillation or atrial flutter, or newly diagnosed atrial fibrillation or atrial flutter during the screening period, as documented by holter ecg or 12-lead ecg at the time of screening or within 12 months prior to screening. exclusion criteria: 1. patients with a mechanical heart valve; 2. rheumatic mitral stenosis or moderate to severe non-rheumatic mitral stenosis; 3. atrial fibrillation or atrial flutter is caused by reversible causes, or successful ablation has been converted to sinus rhythm, or cardioversion or ablation surgery is planned during the study; 4. concomitant poorly controlled hypertension (systolic blood pressure ≥160 mmhg and/or diastolic blood pressure ≥100mmhg) at screening; 5. those who are allergic to the trial drug or any component of the trial drug; 6. unstable or severe liver, renal, cardiovascular, psychiatric, neurological, endocrine, hematological and other diseases at the time of screening, and the investigator judges that it is not suitable to participate in the study; 7. females who are pregnant or lactating.
measurement of cerebral and peripheric tissue oxygenation in anemic preterm infants who underwent blood transfusion

Conditions: Anemic Preterms, Cerebral Oxygenation,Somatic Oxygenation,Blood Transfusion

Summary: near infrared spectroscopy offers the possibility of noninvasive and continuous bedside investigation of cerebral oxygenation in newborn infants. using this technique we investigated the relationship between changes in cerebral oxygenation and hemodynamics, and changes in some physiological variables during blood transfusion in anaemic preterm infants.


Eligibility criteria:
inclusion criteria: \ 30th day preterm infants - exclusion criteria:sepsis,shock,severe intracranial hemorrhage,nec,abdominal and cranial surgery -

Keywords: anemic preterms, cerebral oxygenation,somatic oxygenation, blood transfusion
using yoga to reduce chaos and improve preschooler sleep

Conditions: Sleep, Inadequate; Sleep

Summary: the goal of this intervention study is to learn if a yoga-based bedtime routine is feasible for families to follow and to learn if the routine is effective at improving preschooler sleep. the main question it aims to answer is: will families be able to follow the routine regularly during the study period? will following the yoga routine improve household chaos and preschooler sleep? researchers will compare the yoga group to a control group to see if implementing the yoga routine works better than simple advice to read a bedtime story. participants will be asked to visit the lab 4 times. at the first visit, we will measure body size of parents and children, ask parents to complete some surveys, and fit each of them with an activity monitor. one week later, they will return for the second visit. at this visit, we will collect the activity monitor and assign the participants to either the intervention (yoga) or control (bedtime story) group. families in the intervention group will learn about the intervention and be asked to follow it for the next four weeks. families in the control group will receive a book and advice about reading stories at bedtime. after four weeks, families will return to the lab for a third visit and we will repeat the measurements from visit 1. then, families in the intervention group will be asked to follow the yoga routine as much as they would like to for the next 4 weeks. families in the control group will \&#34;cross over\&#34; to the intervention group and will follow the yoga intervention for 4 weeks. then, families will return to the lab for a 4th visit, where we will repeat all of the measures from the first visit and the study will be complete.


Eligibility criteria:
inclusion criteria: * children between 2.0-5.9 years of age and their self-identified primary parent/guardian exclusion criteria: - parent currently pregnant child or parent unable to walk independently child or parent has an upper body mobility limitation that precludes completion of yoga routine

Keywords: sleep children preschool yoga parents household chaos
exploratory study of the relevance of a blood test in the management of patients in the context of colorectal cancer screening

Conditions: Colorectal Cancer

Summary: colorectal cancer (crc) is the third most common cancer in men and the second in women with an incidence of 43,350 new cases in 2018. this incidence is increasing every year. early detection is crucial in this pathology. in france, free screening is organized by health insurance for people aged 50 to 74 years. this screening is based on an immunological test (fit: fecal immunological test), which aims to detect the presence of blood in the stool. in fact, some polyps or cancers cause bleeding that is often minimal and therefore difficult or even impossible to detect with the naked eye. if this test is positive, a colonoscopy is done to check whether or not abnormalities are present in the colon or rectum. performed under anesthesia, this examination can detect the possible presence of polyps or cancer. recently, with the covid-19 epidemic, the investigators were faced with an extension of the delays for colonoscopies which led to delays in patient care. to prevent this, they propose to develop a blood test that would allow rapid identification of patients with colorectal cancer, requiring rapid management. this blood test will permit to have a parameter for stratifying the therapeutic care in the event of epidemia or situation that constrains the organisation of the health system.


Eligibility criteria:
inclusion criteria: * patients aged more than18 years * cohort a : patients with suspected colorectal cancer following a positive immunological test during screening (presence of blood detected in the stool) or with gross bleeding or cohort b : patients who have already performed colonoscopy (on symptoms, or because of family history, or other ...), for whom the diagnosis of adenocarcinoma was identified by pathology prior to surgery, candidates for surgery on their colorectal tumor * signed and dated informed consent * patient affiliated to or beneficiary of french social security system. exclusion criteria: * vulnerable persons according to the law (minors, adults under protection, persons deprived of liberty ...) * not ability to comply with the study protocol, in the investigator's judgment * pregnant woman * patient in the period of exclusion of another study

Keywords: blood test early detection
a cardiometabolic health program linked with clinical-community support and mobile health telemonitoring to reduce health disparities

Conditions: Hypertension; High Blood Pressure; Diabetes; Chronic Kidney Diseases

Summary: the linked- hearts program is a multi-level project that intervenes at the practice level by linking home blood pressure monitoring (hbpm) with a telemonitoring platform (sphygmo). the program incorporates team-based care by including community health workers (chws) and pharmacists to improve the outcomes of multiple chronic conditions (reduced blood pressure (bp), lower blood sugar, and improved kidney function). the linked-hearts program will recruit a total of 600 adults with uncontrolled hypertension (bp ≥ 140/90 mm hg) and either type 2 diabetes or chronic kidney disease (ckd) across 16 community health centers or primary care practices serving high-risk adults. this cluster-randomized trial consists of two arms: (1) enhanced "usual care arm," wherein patients will be provided with omron 10 series home bp monitors and will be managed by the patients' primary care clinicians as usual; and (2) the "intervention arm" which will integrate hbpm telemonitoring, a chw intervention and provider-level interventions into the usual clinical care to improve bp control and provide support for self-management of chronic conditions. the study pharmacist will conduct telehealth, use the sphygmo app and the pharmacist patient care process to collaborate with other providers to optimize pharmacologic therapy to improve hypertension outcomes and with payors to ensure consistent access to drug therapy.


Eligibility criteria:
inclusion criteria: 1. 18 years of age as of date of data extraction, 2. self-identify as non-hispanic white, non-hispanic black/african american and/or hispanic, 3. diagnosis of hypertension (htn) defined by international classification of diseases, tenth code (icd-10 code) and elevated systolic blood pressure (sbp) measure (≥140 mm hg) on their most recent clinic visit. 4. diagnosis of diabetes or chronic kidney disease (both defined by icd-10 code), in addition to htn 5. receives primary medical care at one of the participating health systems 6. have a maryland and d.c. home address exclusion criteria: 1. age \<18 years 2. diagnosis of end-stage renal disease (esrd) treated with dialysis 3. serious medical condition which either limits life expectancy or requires active management (e.g., cancer) 4. cognitive impairment or other condition preventing participation in the intervention 5. planning to leave the practice or move out of the geographic area in 24 months 6. no longer consider the practice site their location for primary care 7. unwillingness to provide informed consent
the effect of progressive relaxation exercises on fatigue and sleep quality in i̇ndividuals with epilepsy

Conditions: Epilepsy; Sleep; Fatigue

Summary: aim: it was conducted to determine the effect of web-based animation supported progressive relaxation exercise on fatigue and sleep quality in individuals with epilepsy. material and methods: as a randomized controlled study with a pretest- posttest model, it was conducted with individuals with epilepsy who applied to giresun university faculty of medicine neurology outpatient clinic between february and december 2022.the sample of the study was determined as 60 epilepsy patients, 30 of which were in the control-30 experimental group, using power analysis. the data were collected by face-to-face interview technique using personal information form, pittsburg sleep quality index, fatigue severity scale.


Eligibility criteria:
inclusion criteria: * be over the age of 18 * having been diagnosed with epilepsy for at least 6 months * individuals with an average score of 4.1 or higher on the fatigue severity scale * individuals with a pittsburg sleep quality index total score above 5 * being able to use mobile phone (ios-android) * being able to speak turkish * up to 6 months before the study, techniques such as meditation, hypnosis, yoga not benefited, * having a neurological, systemic and psychiatric disease other than epilepsy not to be. exclusion criteria: * not using a mobile phone, * up to 6 months before the study, techniques such as meditation, hypnosis, yoga to have benefited, * having a neurological, systemic and psychiatric disease other than epilepsy be.
using dexamethasone after uvulopalatopharyngoplasty

Conditions: Pain

Summary: this study looks at lessening the pain after a uvulopalatopharyngoplasty (uppp) surgery by using dexamethasone (a corticosteroid).

the study was designed because patients have a lot of pain after they have a uppp. certain drugs called steroids may lessen the pain associated from this surgery. this study uses dexamethasone (a corticosteroid), to see if it will help reduce pain, decrease the amount of time until the patient can begin to eat or return to normal activity, or increase their satisfaction with pain management. in this study the patients will be randomized (computer chosen) to receive either the study drug (dexamethasone), or a placebo. the patient will start the day before surgery with a single pill. they will then receive the dexamethasone or a placebo twice daily for the next four days and then once daily for the next two days for a total of seven days. afterward, they will be asked to complete a questionnaire. the five questions ask patients to access the amount of pain they have, how much of their normal diet or activity they have returned to, and how much pain medication they have taken. at the next follow-up visit they will be asked to complete another questionaire (9 questions) about the patient's satisfaction with pain management.

Eligibility criteria:
inclusion criteria: * candidates scheduled for uppp surgery. * able to take steroids exclusion criteria: * those patients who unable to take steroids

Keywords: uppp dexamethasone uvulopalatopharyngoplasty pain management increasing pain management in patients that have undergone uppp surgery
efficacy of portion size measurement aids

Conditions: Nutrition Assessment; Obesity

Summary: portion size measurement aids (psmas) are tools that facilitate the estimation of food servings. the objectives of this study are to determine (a) if food portion size estimation accuracy differs when using a two dimensional (2d) psma (actual-size photos called portion size cards) compared to a 3d psma (portion size kit) and (b) whether differences exist in the short-term usefulness of and satisfaction with these psmas in a sample of parents of overweight children and youth. we hypothesize that the group that receives the 3d psmas will be more accurate in food portion size estimation and will be more satisfied with the tool compared to the group that receives the 2d psmas.

forty primary caregivers of overweight children and youth attending the pediatric centre for weight and health (edmonton, ab) will be recruited. participants will be randomly assigned to one of the two groups (2d psmas versus 3d psmas). after a brief explanation of the respective tool, participants will estimate the volumes of pre-measured rubber food portion models on a test plate. participants will then be given the 2d or 3d psmas to take home with them to use in the real-world. after 2-4 weeks, participants will be telephoned by the research team to complete a brief survey to evaluate their usefulness of and satisfaction with the 2d or 3d psmas at home.

Eligibility criteria:
inclusion criteria: * participants must be primary caregivers of children or youth attending a clinical appointment for weight management (clients must have a bmi greater or equal to the 85th percentile at this clinic) * participants must be literate and fluent in english exclusion criteria: * any participant who does not meet the above criteria * participants must not have had any previous education or resources on food portion sizes at this clinic

Keywords: nutrition obesity parent portion size estimation accuracy
prediction of the cobrra vte anticoagulant trial in healthcare claims data

Conditions: Venous Thromboembolism; Pulmonary Embolism; DVT

Summary: investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials. the investigators' goal is to understand for what types of clinical questions real world data analyses can be conducted with confidence and how to implement such studies.

this is a non-randomized, non-interventional study that is part of the rct duplicate initiative (www.rctduplicate.org) of the brigham and women's hospital, harvard medical school. it is intended to replicate, as closely as possible in healthcare insurance claims data, the trial listed below/above. although many features of the trial cannot be directly replicated in healthcare claims, key design features, including outcomes, exposures, and inclusion/exclusion criteria, were selected to proxy those features from the trial. randomization is also not replicable in healthcare claims data but was proxied through a statistical balancing of measured covariates through standard practice. investigators assume that the rct provides the reference standard treatment effect estimate and that failure to replicate rct findings is indicative of the inadequacy of the healthcare claims data for replication for a range of possible reasons and does not provide information on the validity of the original rct finding.

Eligibility criteria:
inclusion criteria: * hospitalization for pe or proximal dvt \[day -14, day 0\] * at least 18 years of age exclusion criteria: * prior use of a doac or warfarin \[day -180, day 0\] * stage 4 or 5 chronic kidney disease or end-stage renal disease \[day -180, day 0\] * dialysis or renal transplant \[day -180, day 0\] * recent major or clinically relevant non-major bleeding \[day -180, day 0\] * cancer \[day -180, day 0\] * bypass surgery, obesity, or the use of a weight loss or appetite suppressor \[day -180, day 0\] * significant liver disease and coagulopathy \[day -180, day 0\] * use of cyp3a4 or p-gp inhibitors or inducers \[day -180, day 0\] * other indications for anticoagulation (atrial fibrillation or prosthetic heart valve) \[day -180, day 0\] * pregnancy or breastfeeding \[day -180, day 0\] * use of an antiplatelet \[day -180, day 0\]
registry of the patient experience for carpal tunnel release

Conditions: Carpal Tunnel Syndrome; CTS

Summary: multi-center study to collect large scale, multidimensional real-world data on patients undergoing carpal tunnel release (ctr).

multicenter prospective registry of patients with symptomatic carpal tunnel syndrome (cts) treated (unilateral or simultaneous bilateral) by ultrasound guided ctr (ctr-us), endoscopic ctr (ectr), or open ctr (octr).

Eligibility criteria:
inclusion criteria 1. ≥18 years of age 2. clinical diagnosis of unilateral or bilateral cts 3. a clinical decision has been made to perform ctr on one or both hands 4. cts-6 score ≥12 in the target hand(s)\* 5. confirmatory diagnostic testing in the target hand(s)\*: 1. ctr-us: confirmatory diagnostic testing with ultrasound (median nerve cross-sectional area ≥10 mm2 in the proximal carpal tunnel region) 2. ectr or octr: confirmatory electrodiagnostic testing 6. prior failure of one or more nonsurgical treatment options (e.g., physical activity modification, bracing, splinting, corticosteroid injection) in the target hand(s) 7. patient agrees to complete follow-up questionnaires over a 24-month period 8. patient has a valid smart phone number and/or email address to receive and answer follow-up questionnaires note: an asterisk (\*) denotes that this criterion must be applied to the target hand for unilateral ctr procedures, or to both hands for simultaneous bilateral ctr procedures. exclusion criteria: 1. patient meets any of the contraindications per instruction for use (ifu) 2. patient has other medical, social, or psychological conditions that, in the opinion of the investigator, preclude them from completing all registry requirements.

Keywords: ultrasound guided carpal tunnel release ctr-us ectr octr