Kornimate/medical-research-clean huggingface dataset:
user evaluation of a home-collection kit for people with diabetes

Conditions: Diabetes

Summary: type 1 and type 2 are the most common types of diabetes mellitus. although the cause of type 1 is different to type 2, they can both lead to high blood glucose levels as the patient is unable to store and use sugar. the disease is an epidemic of the 21st century which is increasing, having a current prevalence of approximately 8%. poor disease control is associated with a range of long-term health conditions which have a severe impact upon quality of life and are responsible for the increased morbidity and mortality associated with the disease. healthcare professionals use hba1c as the main marker to monitor diabetic control. patients with diabetes have regular review appointments to monitor their overall health and discuss their hba1c target and results. the purpose of monitoring patients with diabetes is to improve patient outcomes. it is known that poor control is associated with poor clinical outcomes and also that reduced monitoring is linked to suboptimal diabetic control. therefore, aiming for the correct monitoring frequency helps towards achieving the best control which can lead to the most favourable clinical outcomes. the inconvenience of attending for a blood test and follow-up appointment is a major factor affecting patient adherence to monitoring, locally approximately 50% of patients with diabetes have their hba1c level measured either too soon or too late. to address this issue and improve access to monitoring at the correct time interval we aim to produce a hba1c home testing kit which can be posted back to the laboratory at the convenience of the patient. the kit will be developed based on feedback from patients with diabetes and will use a dried blood spot sample to produce hba1c results comparable to the whole blood standard method.


Eligibility criteria:
inclusion criteria: * diagnosis of type i or type ii diabetes * aged 18 years or over * venous blood sample for hba1c collected within the two weeks prior to the clinic appointment * ability to provide fully informed consent exclusion criteria: * non-english speaking where translation of the study documents and procedures could limit fully informed consent * severe visual impairment which would leave the participant unable to complete the study procedures.
a study to evaluate the efficacy of ibi939 in combination with sintilimab in patients with advanced nsclc

Conditions: Advanced Lung Cancer

Summary: this study is an open-label, phase i clinical study to evaluate the efficacy, tolerability and safety of recombinant fully human anti-tigit antibody (ibi939) in combination with recombinant fully human anti-programmed cell death receptor 1 (pd-1) antibody (sintilimab) in subjects with advanced lung cancer.


Eligibility criteria:
inclusion criteria: 1. signed the informed consent form; 2. male or female ≥ 18 and≤75 years of age; 3. life expectancy ≥ 12 weeks; 4. eastern cooperative oncology group performance status (ecog ps) score is 0 or 1 5. have at least 1 lesion (not previously irradiated) with an accurately measured longest diameter ≥ 10 mm by computed tomography (ct) or magnetic resonance imaging (mri) (intravenous contrast agent is preferred) at baseline (except lymph nodes which must have short axis ≥ 15 mm) according to recist v1.1 and lesions amenable to repeated accurate measurements. 6. histologically or cytologically confirmednon-small cell lung cancer exclusion criteria: 1. previous exposure to immune-mediated therapy; previous use of antitumor vaccine; 2. received the last anti-tumor therapy within 4 weeks prior to the first dose of study drug; 3. received any investigational agent within 4 weeks prior to the first dose of study drug; 4. received systemic treatment with chinese herbal medicine indicated for cancer or drugs used for immunoregulation (including thymosin, interferon, interleukin, except for local use for pleural effusion) within 2 weeks before the first dose; 5. are participating in another interventional clinical study, or observational (non-interventional) clinical study or in the follow-up phase of an interventional study;
the effect of reiki on cesarean during hospitalization

Conditions: Cesarean Section Complications

Summary: to determine the effect of reiki applied to women who have been hospitalized by cesarean during the hospitalization process on anxiety, depression, comfort and breastfeeding method: the study will be completed in a randomized controlled manner with a total of 70 women, 35 in the experimental group and 35 in the control group. women in the experimental group reiki therapy will be applied to the participants for 30 minutes while they lie down with their eyes closed. research data will be collected with the comfort scale, hospital anxiety and depression scale and bristol breastfeeding points and will be recorded

design and settings: this randomized controlled experimental study will conducted in the post operative room of the, turkey between the dates of june 2024 and october 2024

Eligibility criteria:
inclusion criteria: * volunteering * be over 18 years old * not having a diagnosed psychiatric disease * no communication problems * no drug sensitivity or allergy * women who have had a cesarean section exclusion criteria: * having a diagnosed psychiatric illness * no communication problems * being under 18 years of age * not volunteering to participate in the research * drug sensitivity and allergy * women who gave birth normally
simplified algorithm for the prevention of postoperative nausea and vomiting in an oncological hospital

Conditions: Postoperative Nausea; Postoperative Vomiting

Summary: previous history of nausea and vomiting induced by prior chemotherapy still not included as predictive factor of postoperative nausea and vomiting, although has been demonstrated that has influence in postoperative outcome. the project aims to evaluate the efficacy of a simplified algorithm in prevention postoperative nausea and vomiting , with pacients with previous history of nausea and vomiting induced by prior chemotherapy, submitted to medium or large surgery.

quasi-experimental study, with evaluation after the application of a specific postoperative nausea and vomiting prevention algorithm for cancer patients. the study will be carried out in 2 phases: phase 1: team training. in this phase, a protocol was established for ponv prophylaxis, using two questions: 1. patient undergoing chemotherapy before surgery; 2. patient presented chemotherapy induced nausea and vomiting (cinv). if the answer is yes to both questions, the anesthetist administers 3 antiemetics (4mg dexametasone, 4mg ondansetron and 0,625mg droperidol). if the answer is no to one of the questions, the anesthetist administers 2 antiemetics (4mg dexametasone and 4mg ondansetron); in this phase, educational measures will be implemented by team meetings and individual approach of all anesthesiologists at icesp to present the study project and the algorithm. a summary of the the study will be sent daily through the social network whats app®. the number of patients was calculated taking into account adherence to the new prophylaxis protocol for post-operative nausea and vomiting. if we consider an alpha error of 5% and test power of 80%, to have a nvpo reduction of 41% (current overall incidence) to 25% (incidence after protocol adherence) in high-risk patients, we need to study 270 patients (135 each group adherence and non-adherence to the protocol). phase 2: post-training assessment. in the second phase of the study, after the end of the dissemination of the protocol among doctors, the patients will be evaluated on the first postoperative day. the following variables were analyzed: sex, race, age, body mass index, general state of american society of anesthesiologist, apfel scale, type of surgery and anesthesia, use and type of opioids, history of chemotherapy induced nausea and vomiting, type of antiemetics used in the operating room and in the first postoperative day, duration of anesthesia and surgery and nausea and vomiting in 6 and 24 hours after surgery.

Eligibility criteria:
inclusion criteria: * all patients who underwent medium to large surgery exclusion criteria: * patients who are unable to communicate (orotracheal intubation after the surgery, confusion or agitation) or understand the portuguese language; * insulin dependent patients * patients who underwent emergency surgery and neurosurgery * pacients who had an increased qt interval on the electrocardiogram * history of allergy to dexametasone, ondansetron or droperidol * refusal to participate

Keywords: nausea vomiting chemoterapy
evaluation study of spotme® skin cancer screenings

Conditions: Skin Cancer

Summary: this study evaluates the impact of the aad spotme® skin cancer screening events on attendees' skin cancer prevention and detection behaviors. this study will also evaluate whether an educational intervention will improve post-screening engagement of attendees with dermatologists.

despite tremendous growth in both the interest and volume of skin cancer screenings at the national level, the actual utility and impact of the aad spot me™ skin cancer screening programs have not been fully evaluated. this study will address this knowledge gap. early detection is vital in the fight against skin cancer, the most common cancer in the united states. while the effects of skin cancer can be devastating, this disease is highly treatable when detected early. this study evaluates the impact of the aad spotme® skin cancer screening events on attendees' skin cancer prevention and detection behaviors. this study will also evaluate whether an educational intervention will improve post-screening engagement of attendees with dermatologists.

Eligibility criteria:
inclusion criteria: * participated in the american academy of dermatology national screening program in 2016 or 2017 * have a presumptive diagnosis (screening, non-confirmed) of melanoma * have provided the aad with permission to be re-contacted * have provided the aad with an email address * aged 18 years or older * able to read english exclusion criteria: * none

Keywords: screening
my health coach study

Conditions: Health Behavior

Summary: the "my health coach study" seeks to determine if health coaching by a medical assistant can help patients have better sleep, a better diet, be more physically active or lose weight, according to the recommendation of their health care provider.

the aim of the study is to determine whether medical assistants (mas) can assist primary care providers to achieve healthier lifestyles via better sleep, food choices, weight loss and/or increased physical activity in their patients. the hypothesis driving this research is that health coaching can be done by existing medical support staff to facilitate healthy lifestyles in a primary care setting. coaching can maximize the health of the patient population in a cost-effective way if the coaching service is integrated into primary care clinics with minimal capital investment at the outset. a major focus will be on behaviors associated with weight management since this is the most common health issue in the u.s. today. this method, if successful, should be easily adaptable to other health behaviors and in most any medical practice that seeks to improve the health of its patient base in a cost-effective way. in order to achieve a change in health behaviors, and especially weight loss, regular follow-up contacts are needed. previous research has shown health coaching to be effective, but this has utilized programs that "add on" to the existing clinic structure. this type of coaching model is difficult to sustain. utilizing existing staff for health coaching is a method we propose to more fully integrate this service into primary care clinics.

Eligibility criteria:
inclusion criteria: * adults age 21 and over * referred by primary care physician for health coaching * have telephone for follow-up * english speaking exclusion criteria: * pregnant or trying to become pregnant

Keywords: nutrition physical activity sleep weight loss
staccato loxapine pk in smokers and nonsmokers

Conditions: Smoking, Cigarette

Summary: the objective of this trial was to assess the pharmacokinetics of a single dose of 10 mg staccato loxapine administered to smokers compared to nonsmokers.

pharmacokinetics and sedation pharmacodynamics were studied using a visual analog scale were studied in male and female adult subjects (nonsmokers and smokers) following a single dose of 10 mg of inhaled loxapine. blood samples were drawn at predose, 30 seconds, 1, 2, 3, 10, 30, and 60 minutes, and 2, 6, 12, and 24 hours after dosing. loxapine and 8-oh-loxapine were analyzed using reverse-phase liquid chromatography coupled with a tandem mass spectrometer.

Eligibility criteria:
inclusion criteria: * normal spirometry at screening and in good general health as determined by a complete medical history, physical examination, 12-lead ecg, blood chemistry profile, hematology, and urinalysis, * smokers must have a history of smoking \> 15 cigarettes/day currently and for at least the last 2 years, * nonsmokers must have never smoked \> 5 cigarettes/day and not smoking at all for at least the last 2 years. exclusion criteria: * any acute illness in the 5 days, * use of a bronchodilator for the treatment of wheezing within 12 months, or * any other disease or condition, by history, physical examination, or laboratory abnormalities that would present undue risk to the subject, or may confound the interpretation of study results.

Keywords: staccato loxapine pharmacokinetics smokers non-smokers
pre-etching of dentin before restorations with high viscosity glass ionomer cement

Conditions: Dental Caries

Summary: the objective of this randomized clinical trial is to evaluate the survival of restoration with high viscosity glass ionomer cement (hvgic) with pre-etching with polyacrilic acid compared with no pre-etching in order to treat occlusoproximais caries lesion in primary molars, as well as the impact of those treatments in the caries lesion progression, the cost-efficacy of the procedures and the discomfort reported by the patient. children of 4 to 8 years will be selected in the pediatric dentistry clinic of universidade ibirapuera. 192 teeth will be randomized in 2 experimental groups: (1) hvgic restoration with pre-etching and (2) hvgic restoration with no pre-etching. will be considered as primary outcome the survival of the restoration evaluated after 6, 12, and 24 months by two trained examiners. the carious lesions progression will be evaluated after 24 months of follow-up. the time of the treatments and the cost of the materials will be considered to estimate the cost-efficacy of each treatment. the discomfort reported by the participant will be measured after each procedure following the wong-baker scale. for the primary outcome, kaplan-meier survival and the long-rank test will be used in order to compare the two groups. cox regression will be performed in order to evaluate thee influence of explanatory variables on the outcome.


Eligibility criteria:
inclusion criteria: * patients with carious lesion of occlusoproximais in primary molars exclusion criteria: * patients will be excluded with special needs, using orthodontics devices and/or systemic diseases which may affect the oral cavity. * also, teeth with pulp exposure, spontaneous pain, mobility, presence of abscess or fistula next to the tooth, teeth with restorations, sealants or enamel formation defects will also be excluded.
medical imaging screening for posterior-circulation ischemic stroke

Conditions: Endovascular Thrombectomy

Summary: patients with ischemic stroke in the posterior circulation continue to have high rates of mortality and disability, even with aggressive treatment. we wanted to evaluate preoperative imaging to screen patients with a good prognosis from mechanical embolization. we assess the degree of ischemia by defining the pons-midbrain-medulla index (pmmi) and correlate the preoperative pmmi with the clinical prognosis of postoperative patients to verify the validity of pmmi in predicting the clinical prognosis of patients with embolization.

* the endostroke registry (endovascular stroke t reatment registry), the use of mri before evt was associated with significantly better clinical outcomes as compared to ct. * the purpose of the study will sift patients with posterior circulation ischemia stroke who will get better outcome by mechanical thrombectomy by neuroimaging.specifically, the following assumption will be evaluated: the modified pons-midbrain index in magnetic resonance imaging can predict the clinical outcome of patients with basilar artery thrombosis 90 days after surgery, and can guide whether patients will undergo mechanical thrombectomy later. * pons-midbrain-medulla index (pmmi) : we divide pons-midbrain-medulla into the left and right sides by the median line of the brainstem,so we will evaluate ischemia of these six layers which are endowed different score according to the degree of ischemia. instead of the previous pons-midbrain index (pmi), we select the image layer that shows the largest infarct size among the six parts.then,we add up six scores that is patient's pmmi. scoring criteria: at the layer of displaying the maximum infarct size, 2 points are scored if the infarct size exceeds 50% of the total area, 1 point is scored if the infarct size is less than 50% of the total area, and 0 points are scored if there is no infarct.finally, pmmi values range from 0 to 12 points. * the investigators conduct a multicenter, prospective cohort study.preoperative images of patients are evaluated by different groups of imaging physicians to describe the association between preoperative pmmi and clinical prognosis in patients with posterior circulation stroke and to verify its validity.

Eligibility criteria:
inclusion criteria: 1. patient admitted from jun. 1st 2019 to jan. 1st 2029; 2. patients with acute ischemic stroke recently； 3. symptoms persisted at admission, and mri (including dwi) confirmed acute ischemic vertebrobasilar artery occlusion in the posterior circulation:（single right or left intracranial branch of vertebral artery occlusion ; single basilar occlusion ; both two vertebral arterys and basilar artery）； exclusion criteria: 1.patiens can not meet the mri examination conditions(with absolute and relative contraindications).

Keywords: select patients endovascular thrombectomy magnetic resonance imaging diffusion weighted imaging vertebrobasilar artery
short-term effects of passiflora and meditation on blood pressure and heart rate

Conditions: Heart Rate Fast; Blood Pressure

Summary: this study is intended to study the effects of one-time acute dosing of a solid extract of passiflora incarnata, also known as passionflower, on blood pressure and heart rate in students. our hypothesis is that blood pressure levels and heart rates will decrease significantly in response to passiflora incarnata.


Eligibility criteria:
inclusion criteria: all university of bridgeport students are invited to participate exclusion criteria: 1. those taking hypertensive medication 2. those taking anti-anxiety medication, including maoi medication 3. those taking blood-thinning medication 4. those who are pregnant 5. those who could be pregnant 6. those who will have surgery 2 weeks before the research date 7. those who are scheduled to have surgery 2 weeks after the research date 8. those who have consumed caffeine, food/tyramine containing foods, stimulant medication, cold medicine, decongestant medicine, antihistamine medicine, cough suppressants, alcoholic beverages, or stimulant energy drinks within 2 hours before the study period.

Keywords: passionflower heart rate blood pressure
repetitive transcranial magnetic stimulation in central neuropathic pain

Conditions: Neuropathic Pain

Summary: the repetitive transcranial magnetic stimulation (rtms) is used in pain treatment for several years. the aim of the study is to assess, in a rigorous scientific protocol, analgesic effect of the neuronavigated rtms assisted by robotic arm on chronic neuropathic painful subjects. the crossover study is randomized, double blinded and controlled (sham rtms) and it includes a large homogeneous population suffering of central neuropathic pain.

the repetitive transcranial magnetic stimulation (rtms) is used in pain treatment for several years. the latest meta-analysis showed that rtms has not prove its scientific efficacy. it could be explained by several reasons: poor methodologic quality, stimulations parameters, technologic hardware, ... the aim of the study is to assess, in a rigorous scientific protocol, analgesic effect of the neuronavigated rtms assisted by robotic arm on chronic neuropathic painful subjects. the crossover study is randomized, double blinded and controlled (sham rtms) and it includes a large homogeneous population suffering of central neuropathic pain. the stimulated region is the primary motor cortex with high frequency (20hz). this study has two periods (real and sham) of 12 weeks with four sessions of stimulation per period and 8 weeks of washout between the two.

Eligibility criteria:
inclusion criteria: * central neuropathic pain * chronic pain with an average pain intensity is greater than or equal to 40/100 * pain presents a daily or almost daily (at least 4 days out of 7) * pain presents for more than 6 months * patients who signed informed consent, * patients whose pain medication is stable for 15 days before to inclusion, and will not need to be modified for the duration of the study, * patients can be monitored for the duration of the study (29 weeks) * patients affiliated to a health insurance plan or entitled, * patients with a cerebral mri t1. exclusion criteria: * labor dispute or accident, * contraindication to rtms (treatment with electroconvulsive therapy during the previous month, epilepsy and / or a history of epilepsy, history of head trauma, neurosurgical injury; intracranial hypertension metal clip; pacemaker pregnant or lactating women) * abuse of drugs or psychoactive substances * peripheral neuropathic pain, * neuropathic pain within the framework of a progressive disease (hiv, cancer, non-stabilized system disease) * intermittent pain, * pain in less than 6 months, * presence of other pain more severe than that justify inclusion, * lack of stability pain scores on two successive evaluations, defined as a change of more than 30% between the two assessments of the average pain between the first two visits (inclusion and first session) * patients unable to understand informed consent, under guardianship, * patients refusing to stop or can not stop the prohibited treatment during the study, * patients participating in another research protocol involving a drug within 30 days before inclusion.

Keywords: neuropathic pain repetitive transcranial magnetic stimulation (rtms)