Kornimate/medical-research-clean huggingface dataset:
the hypoalgesic effects of low load blood flow restriction training (bfrt)

Conditions: Healthy

Summary: a randomized controlled trial comparing the immediate effects of upper limb low-load blood flow restriction training (bfrt) with high load sham-bfrt on hypoalgesia and perceptual response in healthy adults

healthy individuals will be randomized to one of two groups. a target of 40 patients for enrollment has been set for 80% power, p\<0.05 (effect size= 1). a single intervention will be used (40 minutes). intervention group: a single exercise of elbow flexion with blood flow restriction (30-15-15-15 reps) using 30% of 1 repetition maximum. control group: a single exercise of elbow flexion with sham blood flow restriction (4x10 reps) using 65% of 1 repetition maximum. primary outcome: pressure pain thresholds on quadriceps, biceps, lateral epicondyle and upper trapezius (bilateral). secondary outcomes: difference in perceptual response (exertion), change in blood pressure

Eligibility criteria:
inclusion criteria: * bmi\< 30 * able to perform full elbow flexion and extension exclusion criteria: * shoulder tendinopathy, * cervical radiculopathy, * rheumatoid arthritis, * neurological deficit, * serious cardiovascular diseases, * venous deficiency, * history of heart surgery, * cancer history, * breast surgery, * orthopaedic surgeries during the last 6 months, * thrombosis, * diabetes, * body mass index ≥ 30, * crohn syndrome, * family or personal history of pulmonary embolism

Keywords: blood flow restriction pressure pain threshold exercise training
tau opioid use outcomes following discharge from detoxification and short term residential programs affiliated with ctn-0051

Conditions: Opioid Use Disorder

Summary: this is an observational, "ancillary study" intended to describe opioid use among opioid use disorder patients following their discharge into the community from inpatient detoxification and/or short-term residential treatment programs affiliated with parent study ctn-0051, which assessed the comparative effectiveness of extended release injectable naltrexone (xr-ntx, vivitrol®), an opioid antagonist recently approved and indicated for the prevention of relapse to opioid dependence, versus buprenorphine-naloxone (bup-nx, suboxone®), a high affinity partial agonist indicated for maintenance treatment of opioid dependence, as pharmacotherapeutic aids to recovery.

participant recruitment will begin after recruitment for ctn-0051 has been completed. opioid use disorder patients will be recruited prior to leaving detoxification and/or short-term residential programs. screening and baseline data (focused on demographics, diagnosis and service utilization) will be collected prior to discharge, and follow-up data (focused on opioid use) will be collected at weeks 1, 4 and 8 following discharge.

Eligibility criteria:
inclusion criteria: * 18 years or older; * meet dsm-5 criteria for opioid-use disorder (heroin or prescription opioids); * have used opioids other than as specifically prescribed within thirty days prior to consent * seeking treatment for opioid dependence; * able to provide written informed consent; * able to speak english sufficiently to understand the study procedures. exclusion criteria: * serious medical, psychiatric or substance use disorder that, in the opinion of the site pi, would make participation hazardous to the participant, compromise study findings or prevent the participant from completing the study; * suicidal or homicidal ideation that requires immediate attention; * maintenance on methadone at doses of 30mg or greater at the time of signing consent; * presence of pain of sufficient severity as to require ongoing pain management with opioids; * pending legal action or other reasons that might prevent an individual from completing the study; * if female, currently pregnant or breastfeeding or planning on conception; * prior participation in parent trial ctn-0051
investigation of u1-a uterine anomalies implantation markers from the lateral walls of the endometrium

Conditions: T-Shaped Uterus; Infertility, Female; Genital Tract Anomalies

Summary: various types and classes of uterine malformations have been identified and the eshre / esge classification system has recently been published on female genital system anomalies. postoperative positive pregnancy results were obtained in studies conducted in patients with infertility, recurrent implantation failure, and recurrent pregnancy loss, which were not previously described in t-shaped uterine anomalies. considering the increase in endometrial gland and vascularity after the surgical procedure performed in these patients, our primary goal in our study is to compare the number of implantation markers (αvβ3 integrin) and subepithelial glands in the specimen biopsies taken from the lateral walls of the endometrium before and after hysteroscopic surgery in patients with class u1a anomalies.


Eligibility criteria:
inclusion criteria: 1. 18-45 age, 2. have no systemic disease, 3. esge u1-a having uterine anomaly, 4. primary infertile, recurrent implantation loss, recurrent pregnancy loss history, 5. not having previous uterine surgery. exclusion criteria: 1. patients over the age of 45 under the age of 18, 2. those with systemic disease (hypertension, heart disease, asthma, renal disease, liver disease, epilepsy), 3. having previous uterine surgery, 4. those who gave birth.

Keywords: t-shaped uterus infertility, female intregrin beta 3 genital tract anomalies
treatment patterns in metastatic prostate cancer

Conditions: Prostatic Neoplasm

Summary: this study will evaluate treatment patterns, mortality, healthcare resource utilization, and costs in patients with prostate cancer with bone metastases (primary objectives). additionally, this study will evaluate opioid/analgesic use among lines of therapy in this patient population (secondary objective). the study is descriptive in nature and is meant to provide a greater understanding of the patterns of therapy observed in real-world clinical practice (in the absence of clear guideline recommendations with regards to treatment sequencing), to contribute to a greater understanding of the major cost drivers (thus better-informing payers), and to examine real-world mortality in such patients.


Eligibility criteria:
inclusion criteria: - subjects with at least one claim with a primary diagnosis of prostate cancer (international classification of diseases(icd) clinical modification (cm)185.xx )and any of the below on same day or after the prostate cancer claim: * at least one inpatient claim with a primary or secondary diagnosis indicating bone metastases (icd 9 cm 198.5 or healthcare common procedure coding system (hcpcs) code for a treatment indicative of bone metastases or * at least two outpatient claims with a primary or secondary diagnosis indicating bone metastases (icd 9 cm 198.5 or hcpcs code for a treatment indicative of bone metastases, with a minimum of 30 days between claims. exclusion criteria: * subjects with a diagnosis of a cancer other than prostate cancer - defined as the presence of one inpatient or two outpatient claims with a primary or secondary diagnosis of malignant neoplasms (icd-9-cm 140.xx-171.xx, 174.xx-184.xx,186.xx-195.xx,200.xx-209.3x, 230.xx-239.xx) - in the 12-month pre-index period. * subjects with any claim for a primary or secondary diagnosis indicating bone metastases (icd-9-cm 198.5) or any treatment indicative of bone metastases in the 12-month pre-index period. * patients who had a sre in the 12-month pre-index period. * subjects without continuous enrollment for at least 12 months before the index date. * subjects without continuous eligibility for at least 6 months after the index date. * subjects that are female. * subjects that have negative costs. * subjects that are less than 45 years of age on the index date.
attention, teleconferencing and social anxiety

Conditions: Social Anxiety Disorder

Summary: this study involves completing some online assessments and an intervention for social anxiety that all involve interactions with other people on a teleconferencing call.


Eligibility criteria:
inclusion criteria: * age 18-75 * fluent in english because the data collection materials have not yet been standardized in other languages * having access to a computer with a webcam and ability to record audio * personal report of communication apprehension \> 80 * leibowitz social anxiety scale \> 30 * meets dsm-5 criteria for social anxiety disorder exclusion criteria: * significant visual impairment precluding the use of the eye tracking equipment * current, or history of bipolar disorder; current, or history of psychosis
integrated treatment for youth with mood disorders

Conditions: Mood Disorders in Children and Adolescents

Summary: in an effort to understand the effects of evidence-based interventions on children and adolescents, the aims of this study are to: 1. evaluate the feasibility of utilizing wearable devices to track health information (i.e., sleep, physical activity); 2. evaluate the effectiveness of evidence-based intervention components on mood and interpersonal functioning, family engagement, and sleep and physical activity level outcomes.


Eligibility criteria:
inclusion criteria: * children and adolescents between the ages of 10 and 18 years; * diagnosed with a primary depressive or bipolar disorder; * admitted to the child and adolescent integrated mood program (caimp) at mayo clinic. exclusion criteria: * individual's not eligible for admission to the child and adolescent integrated mood program (caimp)at mayo clinic.

Keywords: depression bipolar caregivers children adolescents treatment parents
effects of physical therapy in pain and posture of fibromyalgia patients

Conditions: Fibromyalgia

Summary: the aim of this study is to compare the effects of two physiotherapeutic treatments of fibromyalgia: global postural reeducation associated with cognitive behavioral therapy and segmental muscle stretching exercises associated with cognitive behavioral therapy.

fibromyalgia is characterized mainly by chronic widespread pain. segmental muscle stretching therapeutic exercises reduce the shortening of myofascial structures and recover the body flexibility. it is indicated for the treatment of chronic pain caused by osteo-myo-articular dysfunction. the pain behavior may be defined as the adoption of body postures and attitudes that a person communicates his/her pain. in this way, the global postural reeducation - a method of muscles chains stretching exercises - could be an important intervention. in addition, negative thoughts and dysfunctional beliefs are usual in situations of chronic pain, compromising the health recovery process. as part of a pain catastrophizing-related therapeutic approach, physiotherapist may help patients with chronic pain to develop positive, realistic and hope attitudes as based on the cognitive behavioral therapy model.

Eligibility criteria:
inclusion criteria: * patients with fibromyalgia according to the 2010 american college of rheumatology diagnostic criteria and the presence of at least 11 of 18 tender points. exclusion criteria: * presence of joint deformities * independent walking disability * making another physiotherapeutic treatment at the same time.
role of cryobiopsy in diagnosis of pleural effusion

Conditions: Pleural Effusion

Summary: the purpose of this study is to evaluate the feasibility, size and quality of the specimens obtained by cryoprobe in comparison to those specimens obtained by flexible forceps during medical thoracoscopy in diagnosis of pleural effusion.

* medical thoracoscopy with single-port-of-entry technique will be performed in the bronchoscopy unit under local anesthesia and conscious sedation using midazolam (2 mg) or pethidin. * vertical incision will be made with the scalpel (usually near the midaxillary line), through the skin and subcutaneous tissue, appropriate to the size of the trocar to be used, usually of approximately 10 mm, parallel with and in the middle of the selected intercostal space. * then the trocar will be inserted until the sudden release of resistance (after passing the costal pleura) is felt. * under direct vision with the thoracoscope, introduction of pneumothorax will be performed, and all pleural fluid will be removed, and the pleural cavity will be inspected. * suspicious areas will be biopsied through the working channel of the thoracoscope. * two to six biopsies of a suspicious pleural lesion will establish the diagnosis. technique of pleural biopsy using cryotechnique: * the probe (erbe elektromedizin gmbh( gesellschaft mit beschränkter haftung) , germany of 2.4mm) will be placed perpendicular to the surface of the parietal pleura with the tip of the probe extended well beyond the tip of the scope using the marking on the probe and with direct visualization. * the tip of the cryoprobe will be attached to suspicious part of parietal pleura and activated by footswitch. * carbon dioxide will be used as the cryogen gas for cryobiopsy * the frozen tissue is going to be extracted by gently pulling of the probe. * freezing will be carried out for 6 to 10 seconds depending on the visual assessment of pleural texture.

Eligibility criteria:
inclusion criteria: - 1. unilateral moderate or massive exudative pleural effusion patients. 2. undiagnosed pleural effusion after simple pleural fluid aspiration, cytology or blind (closed) pleural biopsy using abram's needle. 3. age\>18 years old exclusion criteria: 1. transudative pleural effusion. 2. exudative pleural effusion less than one third of hemithorax. 3. presence of hemorrhagic diathesis (prothrombin concentration \<50% and platelet count \<80,000/mm 3). 4. poor performance state (ecog performance status \>4) as recommended in bts (british thoracic society) guidelines 2010. 5. sever uncontrollable cough, hypercapnia and sever respiratory distress. 6. fibrothorax, excessive pleural adhesion. -

Keywords: cryobiopsy
usefulness of wireless ph monitoring in gerd diagnosis

Conditions: Gastroesophageal Reflux

Summary: gastroesophageal reflux disease (gerd) is extremely common in our environment. its diagnosis is complex. the lyon consensus defined, based on 24-hour ph monitoring, that an acid exposure time greater than 6% is definitely abnormal, less than 4% is normal, and between 4 and 6% is a gray area. the objective of this study is to describe the change in therapeutic behavior based on the result of prolonged ph recording performed with a 96-hour wireless ph measurement capsule in patients with gerd symptoms and an acid exposure time measured by impedanciometry/ph of 24 hours in the gray area. also, describe the therapeutic outcomes.

thirty consecutive patients with gerd symptoms and an acid exposure time (aet) measured by impedance measurement/ph between 4 and 6% will be included. a 96-hour off ibp wireless ph monitoring capsule will be performed. the worst day, the average of the 4 days and the presence of 2 or more days with aet\>6% and the 4 days with aet\<4% will be recorded. patients will be categorized into gerd, reflux hypersensitivity, and functional heartburn. a treatment will be established based on these categories and the gerdq will be measured at 8 weeks of treatment.

Eligibility criteria:
inclusion criteria: * patients ≥ 18 years of age, with symptoms of gastroesophageal reflux, who have undergone a 24-hour impedance ph study without proton pump inhibitors (ppis), whose aet is between 4 and 6% will be included consecutively. . exclusion criteria: * patients with severe comorbidities: liver cirrhosis, oncological disease, autoimmune diseases, cognitive impairment, psychiatric diseases, bleeding diathesis or anticoagulation * pregnant women * patients with severe esophagitis, esophageal varices, esophageal strictures, barrett's esophagus, anti-reflux surgery * patients with history of pacemaker or defibrillator, since they can interfere with the signal. * patients with nickel allergy * patients that refuses to sign the informed consent.

Keywords: gastroesophageal reflux disease gray area wireless ph monitoring
open label immunotherapy of myoma

Conditions: Myoma;Uterus; Fibroid Uterus; Leiomyoma; Fibroma

Summary: myoma of the uterus or uterine fibroids are benign tumors that appears in the myometrium or the muscular layer of the uterus. it is one of the most common diseases in pre-climax women, reaching 12-25% of all gynecological diseases. there is an opinion that the true prevalence of myoma is much larger and reaches up to 80%, i.e., practically every second woman has it, often without knowing about. for the treatment of mm, surgical removal of the nodes or removal of the uterus is used. in addition, gnrh-agonist therapy is practiced, as well as embolization to block blood flow in the tumor. we propose to evaluate the immunotherapy approach in an open label phase ii study in 20 women with myoma, for whom no alternative therapy is available.

myoma or uterine fibroids are one of the most common gynecological diseases, which occurs in at least one third of women older than 35 years, and after 40 - in every second. we will test a new tablet preparation, v3-myoma, obtained from hydrolyzed, inactivated blood and tumor tissues of patients with uterine myoma. when administered orally, v3-myoma should cause a specific anti-tumor immune response and an anti-inflammatory effect. such an effect is due to the phenomenon known in immunology, called oral tolerance, leading to a reduction in tumor mass and a decrease in inflammation. an important advantage of our approach is the absence of any negative side effects. in the next three month, we will conduct phase ii open label clinical study of this intervention in 30 women with confirmed diagnosis of myoma.

Eligibility criteria:
inclusion criteria: diagnosed myoma with single or multiple tumors presence of typical clinical symptoms associated with myoma - exclusion criteria: other gynecological diseases not related to myoma hysterectomy -
per-operative ultrasonographic assessement of the placement of the mesh in laparoscopic sacral colpo/hysteropexy

Conditions: LAPAROSCOPY; Sacrum; Anomaly

Summary: this study is conducted in order to determinate the faisability of an intraoperative ultrasound to mesure the positioning of prostheses during laparoscopic promontofixation.

genital prolapse is a very common functional pathology that affects 30% of women. the functional impact of prolapse is highly variable and may lead patients to consider surgery. surgery for laparoscopic genital prolapse (laparoscopy) is a common practice. the placement of prostheses on the anterior and posterior walls of the vagina is sort of "estimated", performed without any quality control . this technique is associated with a high rate of patient satisfaction (90% satisfaction), but a risk of anatomical recurrence in 20-30% of cases and a risk of reoperation for relapse in 3% of cases. it is likely that the lower the intervesico-vaginal prosthesis, the lower the risk of cystocele relapse is important.the postoperative ultrasound visualization of prostheses placed in promontofixation is possible: they appear hyperechoic. in particular, in anterior, where a prosthesis is placed between the vagina and the bladder, it is possible to verify that this prosthesis supports the entire bladder base.thus, it may be possible to check the correct position of the prostheses intraoperatively. if studies were conducted postoperatively, to the best of our knowledge, no study has been conducted on the value of an intraoperative ultrasound control.

Eligibility criteria:
inclusion criteria: * adult women (\>18 years-old) * patient who undergo laparoscopic sacral copopexy/hysteropexy * affiliation to a public health insurance system * written and informed consent given by the patient exclusion criteria: * pregnancy, breast-feading * woan involved in an interventional research * patient under tutorship or curatorship * pregnancy and breast feeding
laparoscopic burch colposuspension versus transobturatory tape for the treatment of female urinary stress incontinence

Conditions: Stress Urinary Incontinence

Summary: transobturatory tape (tot) procedure is a minimally invasive approach to urinary stress incontinence owing to the category of the sling-adopting procedures. its efficacy and safety, also in comparison with similar procedures have been demonstrated. the benefits of the sling- adopting procedures in comparison to laparoscopic burch colposuspension, which has been considered as the gold standard treatment, have been showed. but these comparisons did not included the tot procedure in the experimental arms. based on this considerations the aim of this trial will be to compare tot and laparoscopic burch colposuspension in women with urinary stress incontinence.

women with predominant and genuine stress urinary incontinence will be enrolled and randomized in two groups (groups a and b). patients of group a will be treated with laparoscopic burch colposuspension, whereas patients of group b will be treated with tot procedure. all patients eligible will undergo baseline assessment consisting of anthropometric, clinical, hormonal, urodynamic, and ultrasonographic evaluations. during the study, the surgical outcomes, the clinical subjective and objective efficacy data, and the adverse experiences will be evaluated in each patient. data will be analyzed using the intention-to-treat principle and a p value of 0.05 or less will be considered significant.

Eligibility criteria:
inclusion criteria: * predominant or genuine stress urinary incontinence by self report,examination and test * urethral hypermobility * eligible for both surgical procedures * ambulatory exclusion criteria: * pregnancy * \<12 months post-partum * systemic disease and/or drugs known to affect bladder function * current chemotherapy or radiation therapy * urethral diverticulum, augmentation cytoplasty, or artificial sphincter * recent pelvic surgery * severe genuine stress incontinence (loss of urine with minimal physical activity) with associated prolapse equal to or more than second degree * previous pelvic or anti-incontinence surgery * history of severe abdominopelvic infections * known extensive abdominopelvic adhesions * detrusor instability and/or intrinsic sphincter dysfunction * other gynaecologic pathologies (eg, fibroids, ovarian cysts) * bmi \>30

Keywords: laparoscopic burch colposuspension stress incontinence surgery tot treatment predominant or genuine stress urinary incontinence