Kornimate/medical-research-clean huggingface dataset:
evaluation of naats for detection of c. trachomatis and n. gonorrhoeae from pharynx, rectum, glans & urethra of msm

Conditions: Sexually Transmitted Diseases; Chlamydia; Gonorrhea

Summary: julius schachter, phd, from the department of laboratory medicine at ucsf, and jeffrey klausner, md, from the department of public health, are conducting a study to evaluate a type of test (nucleic acid amplification test) for the detection of two sexually transmitted diseases, chlamydia trachomatis and neisseria gonorrhoeae, in men who have sex with men (msm), using urine samples and swabs taken from the throat (pharynx), tip of penis (glans), and rectum. the use of nucleic acid amplification tests on these swabs is experimental, which means that the use of the tests for this purpose have not been approved by the food \& drug administration.

for all subjects enrolled in the study, the following clinical data information will be obtained: 1) reason for exam, 2) subject's signs and symptoms and 3) clinical assessment. for each subject enrolled in the study, three clinician-collected pharyngeal, four rectal swabs (three clinician-collected, 1 self-collected) specimens, one glans swab (self-collected) and a first catch urine specimen (approximately 25 ml) will be obtained. the collection order of the clinician collected swabs will be randomized. three pharyngeal swabs will be tested for: 1) ct/ng naat (tma) at dph, 2) ng culture at dph and 3) naats for ct/ng (tma, sda) and ct culture at ucsf. four rectal swabs will be tested for: 1) ct/ng naat (tma) at dph, 2) ng culture at dph and 3) naats for ct/ng on clinician- and self-collected rectal swab (tma, sda) and ct culture at ucsf. self-collected glans swab and the fcu will be tested by naats for ct/ng (tma, sda) at ucsf. all naat specimens collected in a universal naat transport medium. after specimen processing, samples will be frozen at -70 c for discrepant analysis.

Eligibility criteria:
inclusion criteria: * a subject must be a man who has sex with men (msm). subjects must provide verbal consent, must be able to submit all required specimens and must not have urinated within 1 hr prior to providing a study urine specimen. exclusion criteria: * subjects are excluded if they do not have sex with men, refuse to give verbal consent, are unable to provide all required specimens and minimum specimen volume, have been on antibiotic therapy within the last 21 days, have urinated within 1 hr prior to submitting study specimens, and have already been evaluated as part of this trial. subjects will be excluded if specimens are mishandled or inappropriately stored.

Keywords: sexually transmitted diseases chlamydia trachomatis neisseria gonorrhoeae
metabolomics of roux-en-y gastric bypass (rygb) with gastrostomy

Conditions: Type II Diabetes Mellitus; Obesity

Summary: this study is an investigation of the "metabolomics of rygb with gastrostomy."

the rapid and durable remission of type ii diabetes mellitis following the gastric bypass operation challenges the current concepts about the etiology of the disease. the surgery, which excludes food from the stomach, duodenum, and proximal jejunum, is quickly followed by a durable drop in glucose and insulin levels. as a result, 4 out of 5 diabetic, morbidly obese individuals who undergo the operation return to a long-term euglycemia with a prolongation of life and a reduction of health care costs. the investigators at east carolina university and those at johnson and johnson propose to further complete the profile of the upper gut by extending their observation to three additional human models. the investigators will study patients having the gastric band procedure, the gastric sleeve procedure, and those who have a gastric bypass but have a peg tube inserted later.

Eligibility criteria:
inclusion criteria: * female * 18-60 years of age * bmi of 35-65 * willing to comply with study requirements and long term follow-up * capable of understanding the requirements and consequences of surgery and the study * is scheduled to have bariatric surgery performed * has a negative pregnancy test exclusion criteria: * repeat gastric bypass procedure * patients who are unable to hold their insulin coverage for 48 hours prior to research visits * patients taking tzds
comparison of technology-assisted and face-to-face assessment in patients with low back pain

Conditions: Low Back Pain

Summary: although the concepts of telemedicine and tele-rehabilitation have been frequently emphasized in recent years, the evaluation part remains inadequate. there is no study investigating remote technology-based balance, mobility and strength assessments in patients with low back pain. therefore, the aim of the study is; it is the examination of face-to-face and technology-based remote balance, mobility and strength assessment in patients with low back pain.


Eligibility criteria:
inclusion criteria * those over the age of 18 * people who can read and write * patients who have not undergone surgery * those whose body mass index is less than 30 m2/kg * volunteering to participate in the study exclusion criteria * patients who underwent surgery due to disc herniation * having any spinal pathology * having an uncontrolled neurological and metabolic disease * having a spinal deformity such as scoliosis or kyphosis * those with serious orthopedic, vascular, neurological or psychiatric problems that affect balance

Keywords: tele-evaluation low back pain face to face evaluation
sitagliptin in non-diabetic patients undergoing cardiac surgery

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to compare sitagliptin and placebo for the prevention of high blood glucose during surgery.

about 80% of patients develop high glucose after cardiac surgery. high glucose is linked to an increased risk of hospital complications. high glucose increases the risk of wound infection, kidney failure and death. patients with high glucose are treated with insulin given through an arm vein or by frequent insulin injections under the skin. this study will determine if sitagliptin can prevent the development of high glucose after heart surgery. sitagliptin is a diabetes pill approved by the food and drug administration (fda) to treat patients with diabetes.

Eligibility criteria:
inclusion criteria: * males or females between the ages of 18 and 80 years undergoing, cardiac surgery * no previous history of diabetes * no previous history of hyperglycemia exclusion criteria: * patients with hyperglycemia (blood glucose \> 125 mg/dl); or glycated hemoglobin (hba1c) \> 6.5%; or previous treatment with oral antidiabetic agents or insulin * severely impaired renal function (serum creatinine ≥3.0 mg/dl or gfr \< 30 ml/min) or clinically significant hepatic failure * moribund patients and those at imminent risk of death (brain death or cardiac standstill) * subjects with gastrointestinal (gi) obstruction or adynamic ileus or those expected to require gi suction * patients with clinically relevant pancreatic or gallbladder disease * treatment with oral or injectable corticosteroid * mental condition rendering the subject unable to understand the scope, and consequences of the study * female subjects who are pregnant or breast feeding at time of enrollment into the study

Keywords: non diabetic hyperglycemia
lung clearance index and lung allograft dysfunction

Conditions: Lung Transplantation; Chronic Lung Allograft Dysfunction; Rejection Lung Transplant

Summary: the aim of this project is to evaluate the ability of the lung clearance index (lci) to detect early chronic lung allograft failure (clad) in adult lung transplant recipients over a period of 3 years.

this single center study consists of three parts: 1. characterisation of the zurich lung transplant cohort regarding clad status and pulmonary function impairment (cross-sectional, study part i) 2. evaluation of test-retest reliability of lci in 20 clinically stable lung transplant recipients during three consecutive study visits (study part ii) 3. prospective cohort study to test the ability of lci to detect early clad in patients without prior clad (study part iii)

Eligibility criteria:
inclusion criteria: * male and female lung transplant recipients * written informed consent by the participant after information about the research project exclusion criteria: * any contraindication to perform pulmonary function tests (e.g., persistent pneumothorax) * acute airway infection * chronic infection due to burkholderia spp and nontuberculosis mykobacteria ntm
chronıc ankle instabılıty and assocıated factors

Conditions: Chronic Ankle Instability

Summary: the purpose of this study was to evaluate the prevalence of chronic ankle instability using the cumberland ankle instability tool (cait) and investigate the independent associated factors. the data was collected from adult volunteers by questionnaire including sociodemographic information, general medical condition, history of orthopedic surgery, pain intensity, and the number of painful areas of the foot.

chronic ankle instability (cai) is a common condition encountered with persistent symptoms of giving way, pain, and weakness and recurrent risk, which may lead to functional insufficiency. the purpose of this study was to evaluate the prevalence of chronic ankle instability using the cumberland ankle instability tool (cait) and investigate the independent associated factors. the data was collected from adult volunteers by questionnaire including sociodemographic information, general medical condition, history of orthopedic surgery, pain intensity, and the number of painful areas of the foot. 273 adult volunteers participated in the study, through face to face or online. subjects are classified as having cai with a cait score ≤27.

Eligibility criteria:
inclusion criteria: * being volunteer * volunteers above 18 years old exclusion criteria: * history of acute ankle sprain * acute ankle fracture * receiving/having received physiotherapy and rehabilitation programs for foot and ankle problems * within the last 6 months,history of foot, ankle, and/or knee surgery * neuromuscular disorders * disorders affecting balance * diabetes mellitus complications

Keywords: chronic ankle instability cumberland ankle instability tool pain
neoamr observational study in neonatal sepsis

Conditions: Neonatal SEPSIS

Summary: prospective, multinational, multicentre, observational cohort study of neonatal sepsis in partner institutions. the cohort study will be designed to evaluate health care utilization and current clinical practice and to assess risk factors for and outcomes of babies with neonatal sepsis (culture-negative and culture-positive).

1. neosepsis: consecutive hospitalized babies with neonatal sepsis will be recruited and followed up until discharge from hospital or death (for a maximum of 28 days). a minimal neonatal sepsis dataset will determine (i) clinical presentations, associated features and risk factors (for example prematurity, sga (small for gestational age)), (ii) rates of culture-positivity among babies with sepsis, (iii) current empirical treatment approaches (antimicrobials selected, dose, etc) (iv) outcomes of sepsis, including death, need for intensive care interventions and recurrence of sepsis during the follow-up period. microbiological samples will be taken from sterile sites, blood and csf, as clinically indicated and will be processed locally. 2. neobsi: consecutive babies with positive blood/csf cultures and sepsis will be recruited. patient inclusion will be based on identification of relevant specified bacteria from blood / csf cultures. in addition to the data collected for neosepsis, information will be collected on the isolates and their antimicrobial susceptibility patterns.

Eligibility criteria:
inclusion criteria: * in-patient in the hospital (nnu (neonatal unit) or paediatric ward) of one of the partner institutions * age \<60 days of age * clinical suspicion of a new episode of sepsis (as defined below)\*\* together with planned treatment with iv antibiotics or new episode of confirmed bacterial meningitis\^ or new episode of infection in which a carbapenem-resistant organism (cro) is isolated from blood culture or new episode of infection in which a candida species is isolated from blood culture * informed consent from parent / guardian * willingness to provide location information and to be contacted at 28 days from start of antibiotic treatment exclusion criteria: * • previously enrolled in this study, unless readmitted and re-started on antibiotics before the 28 day follow-up limit is reached * enrollment in any interventional trial * a serious, non-infective co-morbidity (other than prematurity), anticipated to cause death within 72 hours
the effect of beverages varying in protein quantity on appetite and energy intake

Conditions: Obesity

Summary: over the last decades, changes in the diet and lifestyle have led to overall energy imbalance becoming commonplace and the emergence of an obesity epidemic with more than 1.6 billion adults being overweight. consumption of foods that can affect appetite by increasing satiety could regulate the total energy intake and thus body weight. there is data suggesting that the macronutrient composition of the foods and especially protein content may have a potent role on satiety. however, it is difficult to pinpoint the optimum quantity needed to observe significant effects of protein on satiety. the research project is dedicated to identify which food components \[proteins, carbohydrates (cho), fats\] and the optimized protein quantity needed to accelerate satiation, suppress appetite and extend satiety until hunger appears again. it is hypothesized that the consumption of protein-enriched meals will induce a reduction in hunger through the impact on gut hormones and peptides that are closely related to the short-term regulation of food intake.


Eligibility criteria:
inclusion criteria: * healthy males and females * age range 18-50 years * normal weight and overweight people as classified by bmi:22-27.9 kg/m2 (inclusive). * weight stable (within 3 kg) two months prior to study inclusion * understanding english well and feeling comfortable speaking it exclusion criteria: * dietary protein consumption \>25% energy from protein * had surgery in the previous 12 months * have suffered a myocardial infarction or stroke at any time * suffer from any blood-clotting disorder or prescription of any medication affecting blood clotting * suffer from any metabolic disorders (e.g. diabetes, metabolic syndrome or hypertension) * any requirement to take long-term medication, especially those active on the gastro-intestinal tract or for cardio-vascular disease * any dietary restrictions or recently/currently on a weight reducing diet * irregular eating patterns or not regularly consuming breakfast * food allergies (e.g. milk protein allergies) or intolerances (e.g. lactose) * use of medication which affects food intake or behaviour (e.g. anti-depressants) * use of medication likely to affect taste, smell or appetite * eating restraint based on the three factor eating questionnaire * use of any protein supplements * a history of alcohol or drug misuse (the average daily number of units of alcohol considered as acceptable is 2-3 units women; 3-4 units men * smoking * athletes in training (\>10 h exercise/week) * female that is breast-feeding, pregnant, or if of child-bearing potential and are not using effective contraceptive precautions * involvement in a study involving an experimental drug/medication within 3 months prior to entry of this study * blood pressure \> 160/90 mmhg * vegan or vegetarian * glucose \> 6 mmol/l * gamma glutamyl transferase \> 1.9 μkat / l * alanine transaminase \> 1.1 μkat / l * cholesterol \> 6.5 mmol/l * triglycerides \> 2.0 mmol/l

Keywords: appetite satiety hormones dietary protein
multiple myeloma yoga pilot study

Conditions: Multiple Myeloma

Summary: the purpose of this study is to evaluate the feasibility of implementing a weekly yoga intervention in patients with multiple myeloma on active therapy. this study aims to analyze the impact of yoga intervention on physical symptoms (e.g. pain, fatigue, sleep), psychological symptoms (e.g. anxiety, depression), and overall health-related quality of life (hrqol) in multiple myeloma patients on active treatment.


Eligibility criteria:
inclusion criteria: * any adult of age 18 and above * able to understand basic english * able to provide informed consent * diagnosis of multiple myeloma on active treatment as determined by investigators * good performance status as defined by european cooperative oncology group score 0-1 * able to utilize computer/laptop and smart phone * able and willing to travel to the yoga studio for weekly sessions * able to utilized a wearable device, such as apple watch or fitbit (optional) exclusion criteria: * poor performance status with european cooperative oncology group score 2-4 * actively participating in another clinical trial * poorly controlled mental health symptoms as determined by treating physician * reported fall or syncope in the last 2 months prior to enrollment * concurrent diagnosis of amyloidosis or other cancer requiring active treatment

Keywords: multiple myeloma yoga
international retrospective study of pipeline embolization device

Conditions: Brain Aneurysms

Summary: the primary objective of this retrospective study is to determine the incidence of important safety outcomes in patients who have undergone pipeline embolization device placement for intracranial aneurysms (ias). this study does not effect patient care, simply it is designed to observe and capture information from numerous hospitals. data collection will be initiated starting march 2012 and continue until approximately april 2017.


Eligibility criteria:
inclusion criteria: * a patient who was treated with the pipeline embolization device for treatment of a brain aneurysm

Keywords: brain aneurysm ped pipeline
sodium intake in ecuadorian population

Conditions: Dietary Habits; Risk Factor, Cardiovascular; Nutritional Disorder

Summary: this study is aim to determine the sodium intake in ecuadorian population that is an unknown information at present. for that, 24h urine samples will be collected from 130 subjects working either at tue usfq or hdlv to measure sodium excretion.


Eligibility criteria:
inclusion criteria: * none exclusion criteria: * unable to provide informed consent * unable to provide 24-hr urine excretion sample * those with a known history of heart or kidney failure, stroke, and liver disease * those using diuretics, multivitamins, nsads, or prostaglandins during the last two weeks * pregnant women

Keywords: sodium intake urinary sodium excretion
covera in branch registry

Conditions: Aneurysm

Summary: the purpose of the registry is to evaluate the peri-operative and short-, mid- and long-term outcomes of the bard covera plus (tempe, arizona, usa) for the treatment of atherosclerotic aorto-iliac aneurysm in combination with a multibranched endograft


Eligibility criteria:
inclusion criteria: * adult patients ≥18 years * patients who underwent/will undergo a complex aortic procedure with the use of a covera plus covered stent graft as a bridging stent, in the centres involved in this registry * subject has consented for study participation and signed the approved informed consent exclusion criteria: * bleeding diathesis or coagulopathy * patients with active systemic or cutaneous infection or inflammation * patients who are pregnant or lactating * patient younger than 18 years of age * patients who did not receive treatment using a covera plus covered stent graft.
steroid eyedrop adherence after trabeculectomy

Conditions: Glaucoma; Adherence, Patient

Summary: the study will monitor how often persons use eye drops that are prescribed after glaucoma surgery and will compare the adherence with drop use to the success rate of the surgery.

trabeculectomy is the most common operation performed for all forms of glaucoma. the procedure depends upon appropriately modulated healing of the conjunctiva and sclera, a major component of which is delivery of frequent topical corticosteroid eye drops (prednisolone acetate 1%) by the patient, initially every 2 hours when awake for 1-2 weeks, then in tapering frequency over the 6 weeks after surgery. while the initial success of trabeculectomy at one year varies from 55-80% depending upon the criteria chosen to measure outcome, improvements in success would benefit hundreds of thousands of patients in the usa yearly. there is reasonable evidence that steroid drops benefit success, but there is essentially no data on how successfully patients remember to take the drops. in previous research, investigators have shown that glaucoma patients take only half to two-thirds of prescribed drops. an electronic monitoring device is now available that can fit the eye drop bottle used in steroid drops, accurately measuring the time and date of each drop taken. the investigators can further assess the accuracy with which each patient can deliver a drop from the bottle being monitored in a clinic session directly onto the eye's surface by observing their performance. the proposal's hypothesis is that the one year success rate of the procedure will be related to the adherence to steroid drop taking by patients. the outcome will have two important benefits. first, if adherence is less than ideal (which is very likely), then those with greater adherence will have more successful surgery, confirming that steroid treatment is effective. this has only been measured once, 30 years ago, at a time when trabeculectomy was being performed quite differently. if steroid treatment is not related to success, a change in preferred practice patterns is in order. if steroid treatment is related to success and adherence is variable, the investigation will have proven means to increase adherence through reminder systems, which have shown in past randomized clinical trial to be effective.

Eligibility criteria:
inclusion criteria: * persons having glaucoma surgery exclusion criteria: * persons not eligible for glaucoma surgery, including pregnant females persons allergic to standard postoperative eye drops

Keywords: eye drop
older adult training study with creatine and cla

Conditions: Sarcopenia

Summary: we examined whether creatine monohydrate (crm) and conjugated linoleic acid (cla) could enhance strength gains and improve body composition (i.e., increase fat-free mass (ffm); decrease body fat) following resistance exercise training in older adults (\> 65 y). our study hypothesized that administering crm and cla would yield greater strength and body composition benefits than the placebo group over the six months of resistance exercise

men (n=19) and women (n=20) completed six months of resistance exercise training with creatine monohydrate (5g/d) + conjugated linoleic acid (6g/d) or placebo with randomized, double-blind, allocation.outcomes included; strength and muscular endurance, functional tasks, body composition (dexa scan), blood tests (lipids, liver function, ck, glucose, systemic inflammation markers (il-6, c-reactive protein)), urinary markers of compliance (creatine/creatinine), oxidative stress (8-oh-2dg, 8-isop) and bone resorption (ν-telopeptides).

Eligibility criteria:
inclusion criteria: * healthy, * ambulatory, * recreationally active, * community dwelling exclusion criteria: * evidence of coronary heart disease; * congestive heart disease; * uncontrolled hypertension; * chronic obstructive pulmonary disease; * diabetes mellitus; * renal failure; * major orthopedic disability; and * smoking