Kornimate/medical-research-clean huggingface dataset:
prevalence av bppv among elderly in primary care

Conditions: Benign Paroxysmal Positional Vertigo (BPPV)

Summary: this study aims to investigate whether positional tests should be routinely performed on all elderly patients (65 years and older) presenting to primary care with symptoms of acute, episodic, or chronic dizziness or vertigo, unsteadiness, imbalance, and/or an increased tendency to fall in the past 12 months. study aims to investigate whether diagnostic maneuvers should be performed regardless of the presence of conventional positional vertigo presentation associated with classical cases of benign paroxysmal positional vertigo (bppv). specifically, the study aims to identify "hidden" cases of bppv and assess the potential benefits of clinical screening and initial treatment of bppv in primary care setting thus improving the bppv-related quality of life and reducing the risk of falls in the elderly population.


Eligibility criteria:
inclusion criteria: patients aged 65 years or older and present to the primary care clinic with one or several of the following: 1. acute, episodic, or chronic sensation of dizziness/vertigo. 2. subjective or objective imbalance during stance or movements. 3. presented with increased tendency of falls by exhibiting unintentional loss of balance resulting in a fall one or more times in the past 12 months. exclusion criteria: 1. patients not meeting the above epidemiological and medical criteria described under "inclusion criteria". 2. patients presenting with pathologies in which head and neck movements/manipulations are contraindicated, including (but not limited to): cervical instability, acute head and neck trauma, known cervical disk prolapse, arnold-chiari malformation, vascular pathologies such as carotid sinus syncope, vascular dissection and vertebrobasilarinsufficiency, including patients with paralysis as well as those with reduced mobility, in whom diagnostic maneuvers cannot be correctly performed.
the physical and mental health of people with type ii diabetes mellitus.

Conditions: Adult ALL; Diabete Type 2

Summary: to analyze the effects of a pilates exercise program on physical and mental health in people with type ii diabetes mellitus.

this is a randomized clinical trial of single-blind with 2 arms (control group and experimental group), in which a pre-treatment-postest design has been used. the study will define two groups: * a control group (cg) that will not be submitted to treatment, which will be evaluated in the pre and post phase of the study. participants assigned to this group will receive general advice on the positive effects of regular physical activity and will be given a guide to recommendations for promoting physical activity. * an experimental group (ge) that after an initial evaluation will undergo a physical training program based on pilates exercises. once the intervention is finished, it will be submitted to a final evaluation to see if there is a difference or not with the results obtained at the beginning.

Eligibility criteria:
inclusion criteria: * diagnosis of type 2 diabetes mellitus * not participating in an exercise program * that they were able to carry out the different selected questionnaires. exclusion criteria: * contraindications for performing physical tests * illnesses that limit static and dynamic balance and physical activity * central or peripheral vestibular or nervous disorders.
investigator-initiated clinical trial (phase ii) of cancer vaccine "dainippon sumitomo phama(dsp)-7888" for acute myeloid leukemia patients.

Conditions: Acute Myeloid Leukemia in Remission

Summary: this study is an investigator-initiated clinical trial (phase ii) using dsp-7888 for acute myeloid leukemia patients with 1st hematological complete remission (cr). dsp-7888 is a novel cocktail peptide vaccine designed to induce cytotoxic t lymphocytes that recognize wilms tumor gene 1 (wt1) peptides.

this study is an investigator-initiated clinical trial (phase ii) using dsp-7888 for acute myeloid leukemia patients with 1st hematological cr. dsp-7888 is a novel cocktail peptide vaccine designed to induce cytotoxic t lymphocytes that recognize wt1 peptides. primary endpoint is relapse-free survival, and 2nd endpoint is hematological relapse-free survival, overall survival and adverse event.

Eligibility criteria:
inclusion criteria: 1. acute myeloid leukemia defined by world health organization (who) 2016 classification 2. favorable or intermediate risk based on european leukemia net (eln) 2017 risk classification 3. 1st hematological after chemotherapy 4. human leukocyte antigen (hla)-a\*02:01, 02:06, 24:02 5. 20-80 years old 6. eastern cooperative oncology group (ecog) performance status 0-2 7. within 35 days after white blood cell (wbc) and neutrophil recovers over 1500 and 500, respectively 8. sufficient organ function as below within 7 days (1) neutrophil : \>= 1000 (2) cr : \>= 3.0mg/dl (3) aspartate aminotransferase (ast), alanine transaminase (alt) : 5 x the upper limit of normal (uln) for the reference lab (4) percutaneous oxygen saturation (spo2): \>= 95% 9) patients who agree contraception until 6 months after the last injection 10) non-candidate for hematopoietic stem cell transplantation. 1. illegible for hematopoietic stem cell transplantation (hsct) 2. lack of appropriate donor 3. patients who don't select hsct at the 1st hematological complete remission (hcr) timing exclusion criteria: 1. multiple primary cancer 2. autoimmune disease 3. usage of investigational or unapproved drug within 28 days 4. severe organ failure 5. human immunodeficiency virus (hiv) antibody / hepatitis b surface (hbs) antigen / hepatitis c virus (hcv) antibody positive 6. pregnant woman 7. lactating woman 8. under treatment against active infection 9. difficult to enroll because of mental problem 10. other reasons which investigator judge appropriate for enrollment
threat-avoidance learning in anxiety patients

Conditions: Panic Disorder; Phobic Disorders; Stress Disorders, Traumatic

Summary: anxiety disorders are characterized by exaggerated levels of fear that are not proportional to the actual level of threat. more specifically, anxiety patients have marked deficits in the downregulation of fear reactions during situations of objective safety. pre-clinical research on pavlovian fear conditioning and extinction has discovered that fear downregulation stems from areas in the prefrontal cortex (the ventro-medial prefrontal cortex, vmpfc) that recruit intercalated cells in the amygdala to inhibit its central nucleus, which is responsible for a variety of behavioral expressions of fear (milad \& quirk, 2012). accordingly, functional magnetic resonance imaging studies (fmri) revealed reduced vmpfc activity coupled with increased fear reactions during situations of objective safety in anxiety patients (milad et al., 2009). another core symptom of anxiety disorders, though much less investigated, is the excessive avoidance of situations that trigger the fears. these 'safety behaviors' often interfere with daily life activities and valued goals in life, and they are thought to perpetuate the exaggerated levels of fear by precluding opportunities to learn that the feared situations are actually not dangerous. surprisingly, experimental research on avoidance behaviors in anxiety patients is virtually non-existent. this experiment modifies the pavlovian fear conditioning procedure to include avoidance, and explores the behavioral and neural processes of this type of fear regulation in anxiety patients (trans-diagnostically) and healthy individuals.


Eligibility criteria:
inclusion criteria: * 18-65 years of age. proficient in english. right-handed free of medication that affect cerebral metabolism. able to give informed consent. high stress level (defined as a score of \>= 3 on the 4-item perceived stress scale). exclusion criteria: history of neurologic or psychiatric disease (other than the specified anxiety disorder), substance abuse or dependence that is current or within the last year. major/chronic medical conditions. history of head injury resulting in prolonged loss of consciousness and/or neurological sequelae. history of seizures. history of stroke prior neurosurgical procedure. metal in the body, metal injury to the eyes. implanted pacemaker, medication pump, vagal stimulator, deep brain stimulator, tens unit, or ventriculo-peritoneal shunt. pregnancy; breastfeeding or nursing claustrophobia weight \> 350 lbs.

Keywords: anxiety fear avoidance
impact of postoperative pyuria on treatment outcomes after pvp

Conditions: Prostatic Hyperplasia; Pyuria

Summary: the aim of this study was to identify serial changes in the incidence of postoperative pyuria after the photoselective vaporization of the prostate (pvp), to determine whether the presence of postoperative pyuria could be correlated with surgical outcomes after surgery and to identify predicting factors that influence on persistent pyuria after the pvp.


Eligibility criteria:
inclusion criteria: * men who underwent photoselective vaporization (pvp) using 80 watt potassium-titanyl-phosphate (ktp) laser or 120 watt high-power-system (hps) laser for benign prostatic hyperplasia refractory to medical treatment * sterile urine on urinalysis and urine culture before surgery * absence of indwelling urethral catheter before surgery exclusion criteria: * previous diagnosis of prostate carcinoma or bladder cancer * co-existence of urinary stone * any antibiotic treatment within 2-weeks before surgery
statins and arbs on rheumatoid activity

Conditions: Rheumatoid Arthritis

Summary: investigational and comparative study between the anti-inflammatory effectof both angiotensin reeptor blockers and statins on rheumatoid arthritis disease activity on egyptian patients

the study aims at ivestigating and comparing the anti-inflammatory effectof both angiotensin reeptor blockers and statins on rheumatoid arthritis disease activity on egyptian patients

Eligibility criteria:
inclusion criteria: * rheumatoid arthritis. exclusion criteria: * pregnant or lactating * hepatic or renal impairment.
effect of increased enteral protein on body composition of preterm infants

Conditions: Premature Infant

Summary: the study hypothesis is that, in human milk-fed extremely preterm infants, higher protein intake compared to usual protein intake reduces percent body fat (%bf) at 3 months of age.

qualifying participants will be randomly assigned to receive either standard protein supplementation (control group) or high protein supplementation (intervention group). intervention group: a fixed amount of commercially available hydrolyzed bovine protein will be added to fortified human milk after establishment of full enteral feeding. control group: hydrolyzed bovine protein will not be added to fortified human milk after establishment of full enteral feeding. if parent agrees, stool "dirty" diapers will be collected 2 times (at the time of hospital discharge and at 3 months of corrected age).

Eligibility criteria:
inclusion criteria: * gestational age between 25 and 28 weeks of gestation * feeding volumes of ≥120 ml/kg/day before or on postnatal day 14. exclusion criteria: * necrotizing enterocolitis (nec) stage 2 or greater. * gastrointestinal or neurologic malformations. * terminal illness needing to limit or withhold support will be exclusion criteria.

Keywords: protein supplementation human milk fortification
a study of the cataractogenic potential of seroquel and risperdal in the treatment of participants with schizophrenia or schizoaffective disorder

Conditions: Schizophrenia; Schizoaffective Disorder

Summary: this phase iv, randomized, parallel-group study is designed to evaluate the cataractogenic potential of quetiapine fumarate (seroquel) compared with that of a putative non-cataractogenic antipsychotic medication risperidone (risperdal). this study is being conducted to fulfill the seroquel phase iv commitment regarding evaluation of cataractogenic potential.


Eligibility criteria:
inclusion criteria: * men and women age 18 to 65 * both eyes present with lenses intact (no previous cataract extractions) * stable place of residency exclusion criteria: * history of corneal surgery * legal blindness (defined as best corrected visual acuity of 20/200 or worse in one or both eyes * previous participation in this study

Keywords: schizophrenia schizoaffective disorder
control of pain due to dentin hypersensitivity in individuals with molar-incisor hypomineralization

Conditions: Dentin Sensitivity; Molar Incisor Hypomineralization

Summary: background: dentin hypersensitivity (dh) is defined as high sensitivity of the vital dentin when exposed to thermal, chemical or tactile stimuli. two mechanisms are required for the occurrence of dh: 1) the dentin must be exposed and 2) the dentinal tubules must be open and connected to the pulp. molar-incisor hypomineralization (mih) is a qualitative abnormality of a genetic origin that affects tooth enamel and, in most cases, is accompanied by dh. the control of tooth sensitivity is fundamental to the successful treatment of mih. objective: the aim of the proposed randomized, controlled, clinical trial is to evaluate the effectiveness of different protocols for the control of dh in patients with teeth affected by mih. methods: one hundred forty patients who meet the inclusion criteria will be allocated to four groups. group 1 will be the control group (placebo). in group 2, sensitive teeth will be sealed with permaseal (ultradent). in group 3, sensitive teeth will receive low-level laser (lll) (asgaal) at a wavelength of 780 nm (laser xt therapy, dmc, são carlos, sp, brazil). in group 4, sensitive teeth will be treated with both lll and permaseal (ultradent). dh will be evaluated 15 min after the application of the treatments and the patients will be reevaluated one week, one month, three months and six months after the treatments. discussion: this study will enable the determination of differences in the effectiveness of the proposed treatments as well as differences among the evaluation times for each proposed treatment.


Eligibility criteria:
inclusion criteria: * age between 18 and 35 years; * good overall health; * at least one tooth with mih and dh reported in the cervical region with sensitivity equal to or greater than 4 on the vas. exclusion criteria: * active caries or defective restorations on the tooth to be analyzed; * sufficient dentin loss that requires restorative treatment or periodontal surgery; * having undergone any professional desensitizing treatment in the previous six months; * having used a desensitizing paste in the previous three months; * use of anti-inflammatory drugs or analgesics at the time of recruitment; * currently pregnant or nursing.
wii fit based exercises and proprioceptive exercises in diabetic neuropathy patients

Conditions: Diabetic Neuropathies

Summary: this project is a randomized clinical trial that will be conducted to check the effects of wii fit based exercises and proprioceptive training on balance and fall risk in patients with diabetic neuropathy, duration of study will be of 6months, convenient sampling will be used, subject following eligibility criteria from riphah rehabilitation centre, patients will be randomly allocated into two groups; group a will be treated with wii fit based exercises (40 mins session, 3 days/week, penguin slide, soccer heading, tilt table, tightrope walking) \& group b will be treated with proprioceptive training (40 min session, 3 days/week, toe walking, heel walking, cross-body leg swings right and left sides, partial squat, ). in both groups pre and post-test measurements of balance and fall of risk will be assessed through berg balance scale, star excursion, modified fall efficacy scale, and timed up and go (tug). evaluation will be done before the session start and at the end of 6th week.

diabetes mellitus is a disorder in which the body does not produce enough or respond normally to insulin, causing blood sugar (glucose) levels to be abnormally high. diabetic neuropathy is a serious diabetes complication that may affect as many as 50% of people with diabetes. the nerve damage associated with diabetic peripheral neuropathy (dpn) may reduce the proprioceptive inputs that contribute to decreased balance and an increased risk of falling. wii fit balance board improves balance in older adults through training. wii fit balance board showed significant improvement in balance and decrease the risk of fall. proprioceptive training is an intervention that targets the improvement of proprioceptive function in patients. the aim of the current study is to determine the effects of wii fit based exercises and proprioception training on balance and fall of risk in patients with diabetic neuropathy

Eligibility criteria:
inclusion criteria: * 40-80 years of age; * medical diagnoses of diabetes under regular medication control * dn4 score ≥ 4 * independent community ambulatory individuals; * intact cognition (minimental state examination score of \>24 exclusion criteria: * other neurological diseases such as dementia, parkinson's disease, spinal cord injury, or stroke; * severe visual impairment, musculoskeletal disorders, unhealed plantar ulceration, lower limb amputation, poor cardiopulmonary function, or other diseases affecting walking ability or any other disease due to which individuals were unable to walk without assistance * any other condition associated with a high risk of falling

Keywords: wii fit proprioceptive fall balance diabetic neuropathy
airway clearance and bronchoalveolar lavage for bronchiectasis patients with exacerbation

Conditions: Bronchiectasis Adult

Summary: no study have evaluated the efficacy and safety of airway clearance therapy (act) and bronchoalveolar lavage (bal) under bronchoscope for bronchiectasis. this study aimed to evaluate the clinical efficacy and safety of tran-bronchoscopy airway clearance and bronchoalveolar lavage in the treatment of moderate to severe bronchiectasis with acute exacerbation:a randomized, prospective cohort study.

the aim of this study was to evaluate the efficacy and safety of act combined with bal for bronchiectasis patients with acute exacerbation through the whole study process, which will provide a high quality of evidence-based strategies for the treatment, revision and optimization of international and domestic clinical guidelines for bronchiectasis. all the participants will be required to check the various efficacy and safety indicators.

Eligibility criteria:
inclusion criteria: * willing to join in and sign the informed consent form; * the diagnosis of bronchiectasis need reference to the definition of "european respiratory society guidelines for the management of adult bronchiectasis." published by the european respiratory journal in 2017, defined by the presence of both permanent bronchial dilatation on computed tomography (ct) scanning and the clinical syndrome of cough, sputum production and/or recurrent respiratory infections; * pulmonary exacerbation in patients with bronchiectasis was required to meet three or more of the following key symptoms for at least 48h: cough; sputum volume and/or consistency; sputum purulence; breathlessness and/or exercise tolerance; fatigue and/or malaise; haemoptysis, and a clinician determines that a change in bronchiectasis treatment is required; * according to the researchers, the subjects were willing and able to follow the protocol and were able to tolerate bronchoscopy; * patients with good compliance: the subject must be willing to follow the test plan requirements in the research center to complete all the assessment of the visit. exclusion criteria: * pregnant or lactating women; * hypogammaglobulinemia or other autoimmune diseases; * clinical diagnosis of abpa; * non tuberculosis mycobacteria positive 2 years before; * allergies or allergic to a variety of drugs; * poor compliance or can not cooperate judged by doctors; * participated in other clinical trials for nearly three months; * the researchers considered that the subject had other circumstances that were unfit to attend; * suffering from a significant disease or condition outside of bronchiectasis, as judged by the researchers, may lead to subjects at risk due to participate in the study,or the disease that have an impact on the research result and the ability of subjects to participate in this study; * bronchoscopy contraindication; * patients with heart, liver and kidney, nervous system, endocrine and other systemic diseases, may not be able to adhere to the completion of the study, or will affect the research process; * patients who refused to sign informed consent after targeted explanation.
vasospasm in pediatric traumatic brain injury

Conditions: Brain Injury

Summary: the purpose of this study is to assess for vasospasm using transcranial doppler (tcd) and brain injury biomarkers, and evaluate neurocognitive outcome data in pediatric traumatic brain injury (tbi) patients who have experienced a mild to severe head injury.


Eligibility criteria:
inclusion criteria: 1. admission to duke university children's hospital; 2. age 5 days to 15 years; 3. a diagnosis of a tbi with a gcs 3-15; 4. capable of adequate tcd ultrasound examination; 5. and presence of intravenous or arterial access (blood) and/or an evd for cerebrospinal fluid (csf) and/or foley catheter/ability to void unassisted (urine) biomarker collection unless they are excluded based on the exclusion criteria. exclusion criteria: * the presence of previously diagnosed significant neurodevelopmental delay, * a diagnosis of non-traumatic intracranial hemorrhage and * parents/legal guardians who do not speak or understand english.

Keywords: traumatic brain injury brain injury head injury vasospasm
database for clinical and anamnestic data in pulmonary hypertension

Conditions: Pulmonary Hypertension

Summary: pulmonary hypertension (ph) is defined as a pulmonary arterial mean pressure (meanpap) ≥ 25 mmhg measured in the right heart catheterization. there are different forms of ph defined in the classification of dana point 2008. ph is diagnosed with right heart catheterization but there are other non invasive methods which can be used for screening like the echocardiography, stress echocardiography and cardio pulmonary exercise testing. in the diagnosis process and in the follow up of ph patients biomarkers like ntprobnp are helpful. there are no specific biomarkers for the disease which can make the diagnosis process easier and predict prognosis. the systematic data collection in a data base provides better information about patients in daily routine and clinical studies as well as in the design of new studies.

in this study the investigators want to collect clinical data of ph patients and controls in a database as well as blood samples in a biobank. the combination of anamnestic and clinical data and biomarkers should provide a better characterization of our patients and should improve the analysis of the disease development of different ph forms and therapeutic aspects. after given informed consent patients' data are entered in a database at different time points. the database includes parameter of several invasive and non-invasive investigations like right heart catheterization (rhc), echocardiography, ecg, pulmonary function tests, cardiorespiratory exercise testing, 6-minute walk test, computed tomography, mri, polysomnography, blood gas analysis and laboratory data as well as demographic data of the patients. the blood samples are taken during routine punctuation and are stored in our biobank.

Eligibility criteria:
inclusion criteria: * patients with pulmonary hypertension * patients at risk for getting pulmonary hypertension * patients who have symptoms which my be due to pulmonary hypertension when we have their written informed consent. exclusion criteria: * patients without written informed consent

Keywords: pulmonary hypertension database biomarker