Kornimate/medical-research-clean huggingface dataset:
preoperative strength training in patients with total knee arthroplasty

Conditions: Osteoarthritis, Knee

Summary: the purpose of this study is to investigate if preoperative strength training will result in faster recovery and higher level of function six weeks after total knee arthroplasty (tka).

reduced strength of the quadriceps muscle is a common clinical finding in patients with knee osteoarthritis and this seems to play a central role in the development of the disease. the strength of the quadriceps muscle have been shown to be reduced by 20-40% as compared to age-matched healthy controls and this decrease in muscle strength have been closely associated with a reduced level of function and increase of pain. furthermore, it has been demonstrated that the preoperative strength of the quadriceps muscle in patients undergoing tka, is associated with the level of function one year after surgery. compared to the level before the operation, an additional operation-induced reduction of the strength of the quadriceps muscle up to 60% as has been demonstrated. presumably, an optimizing of the strength of the quadriceps muscle could counteract the impact of the expected postoperative loss of muscle strength to such an extent that the loss will be of less clinical significance. it is hypothesized that an optimizing of the strength of the quadriceps muscle may have a favorable effect on the postoperative rehabilitation program and shorten the period of convalescence.

Eligibility criteria:
inclusion criteria: * planned tka at the aarhus university hospital or region hospital silkeborg, * living in aarhus municipality, * primary knee osteoarthritis or secondary osteoarthritis after meniscectomy or ligament injury exclusion criteria: * unstable blood pressure, * neuromuscular or neurodegenerative disease, * comprehension or dementia problems

Keywords: knee osteoarthritis total knee arthroplasty preoperative training strength training
algorithm guided dbs programming in parkinson's patients

Conditions: Parkinson Disease

Summary: patients undergoing deep brain stimulation for parkinson's disease will be subjected to standard of care programming and compared with the algorithm based programming (stimsearch). various parameters including the effectivity and efficiency of algorithm programming will be compared against the standard of care programming.

patients of parkinson's disease undergoing bilateral subthalamic nucleus stimulation (stn), we have already been adequately programmed and have achieved good outcome, will undergo an exploratory study to evaluate the effectiveness of algorithm based programming (phase 1). subsequently, patients undergoing stn dbs will be randomly allocated to algorithm based programming/ standard of care programming and after adequate stabilisation evaluated for motor improvement. they will be switched over to the alternative technique of programming and evaluated again after a similar period. data regarding the time consumed, effectivity and several secondary endpoints will be evaluated.

Eligibility criteria:
inclusion criteria: * have a confirmed diagnosis of bilateral idiopathic parkinson's disease * exhibit a updrs subset iii score of ≥ 25 while in the preoperative medication off state * demonstrate an improvement of parkinson's disease symptoms by ≥30% in the medication off state following a pre-operative levodopa challenge, as assessed by the updrs subset iii score * possess the ability to comprehend the study's demands, treatment protocols, and procedures, and provide written informed consent before undergoing any study-specific tests or procedures exclusion criteria: * patients with notable psychiatric conditions, including unrelated clinically substantial depression as assessed by the investigator, will be excluded from participation.

Keywords: deep brain stimulation programming parkinson disease
a study on the relationship between job satisfaction and retention intentions of emergency room nurses

Conditions: A Study on the Relationship Between Job Satisfaction and Retention Intentions of Emergency Room Nurses

Summary: based on a survey conducted by the nursing and health care bureau of the ministry of health and welfare in 2023, which investigated the recruitment and turnover rates of nursing personnel in 479 hospitals of different levels, the results revealed that the recruitment of nursing personnel was exceedingly challenging. the difficulty levels varied, with medical centers at 80%, regional hospitals at 67.9%, and district hospitals at 43.37%. additionally, the turnover rates of nursing personnel were notably high, with medical centers at 10.21%, regional hospitals at 11.17%, and district hospitals at 14.52%. these rates all exceeded 10%, which means that, on average, one out of every ten nursing personnel resigned (nursing and health care bureau, ministry of health and welfare, 2023). this study aims to investigate the relationship between job satisfaction and retention intention among emergency room nursing personnel in a regional teaching hospital in yunlin county. in the fiscal year 2023, the unit experienced an alarming turnover rate of approximately 82% among newly hired personnel. therefore, the study intends to conduct further research and exploration into the job satisfaction and retention intention of emergency room nursing personnel. the primary objectives of the research include examining the correlation between the demographic characteristics of emergency room nurses and their job satisfaction, the correlation between the demographic characteristics of emergency room nurses and their retention intention, and the correlation between job satisfaction and retention intention among emergency room nurses. the study's subjects are nurses or nursing staff employed in the emergency department. the research is conducted through the distribution of questionnaires, and all responses are collected anonymously. the questionnaire is structured into three main sections: the first section covers demographic characteristics, the second section addresses job satisfaction items, and the third section focuses on retention intention items. upon collecting and encoding the data, the information will be compiled, and statistical analysis will be performed using excel and spss version 25.0 statistical software to validate various research hypotheses. the expected outcome of the study is a positive relationship between job satisfaction and retention intention among emergency room nurses, indicating that job satisfaction influences retention intention.


Eligibility criteria:
inclusion criteria: * emergency nurse * employed in an urgent care unit. * holds a nursing or registered nurse license. * currently engaged in nursing duties. * has a minimum of three months of nursing service in this hospital. exclusion criteria:

Keywords: emergency room nurses 、 job satisfaction 、retention intentions
ankle joint replacement outcomes study

Conditions: Osteoarthritis; Rheumatoid Arthritis; Post-Traumatic Arthritis; Septic Arthritis; Prior Ankle Fusion

Summary: this post market outcome study will look at the therapeutic results of the salto talaris anatomic ankle prosthesis. the study population will consist of patients who will undergo an ankle arthroplasty procedure with a salto talaris ankle implant. an analysis will be conducted of the results, complications and revisions of this prosthesis based on the etiology for which the ankle arthroplasty was performed.

this is a prospective, multi-center study that will capture the therapeutic results of the salto talaris anatomic ankle prosthesis in the treatment of various ankle afflictions.

Eligibility criteria:
inclusion criteria: * subjects that need an ankle joint replacement due to arthritis or failed prior fusion. * subjects who have failed standard conservative management of their ankle condition exclusion criteria: * class iv or higher anesthetic risk * subjects who are not able to comply with the study procedures * known contraindications to joint replacement such as active infection, complete talar necrosis, insufficient quality of bone stock, ligament laxity, severe osteopenia, charcot's arthropathy * unwilling to be followed for 5 years

Keywords: arthritis osteoarthritis arthroplasty
repeated methotrexate for proliferative vitreoretinopathy grade c

Conditions: Proliferative Vitreoretinopathy

Summary: this multicenter randomized clinical trial evaluates the effect of multiple intra-silicone oil injections of methotrexate (mtx) on rhegmatogenous retinal detachment (rrd) with grade c proliferative vitreoretinopathy (pvr). 74 eyes with the diagnosis of rrd with pvr grade c will be randomized into two groups: the intervention group and the control group. all eyes undergo pars plana vitrectomy(ppv) and intraocular injection of silicone oil (so). at the end of the surgical procedure, intra-so injection of 250 µg mtx will be performed in the intervention group. no intra-so injection will be done in the control group. in the intervention group, intra-so injection of mtx will be repeated at 3 and 6 weeks postoperatively. silicone oil removal will be done 3 months after surgery.spectral-domain optical coherence tomography (sd-oct) image of the macula will be acquired at months 3 and 6. the retinal reattachment rate at months 6 will be assessed as the main outcome measure of the study. best corrected visual acuity, retinal reproliferation rate and adverse events are the secondary outcome measures. comprehensive ocular examination will be performed at weeks 1, 3, 6 and at months 3, 4 and 6.


Eligibility criteria:
inclusion criteria: * rhegmatogenous retinal detachment with proliferative vitreoretinopathy grade c exclusion criteria: * age of under 18 years old * pregnancy * glaucoma * macular disorders * diabetic retinopathy * retinal vascular occlusion * history of penetrating ocular trauma * giant retinal tear * chronic uveitis * history of intraocular steroid injection
nutritional support during antiviral therapy for hepatitis c

Conditions: Hepatitis C; Weight Loss

Summary: standard antiviral treatment consists of weekly injections with peginterferon-α in combination with ribavirin. this treatment may lead to significant weight loss (7% within 24 weeks on average), with decreased quality of life. in this study the investigators will examine in 50 patients whether nutritional advise and support can prevent weight loss during antiviral therapy.

standard antiviral treatment consists of weekly injections with peginterferon-α in combination with ribavirin. this therapy, however, leads to weight loss of approximately 7% in the first 24 weeks of therapy possibly related to impaired postprandial gastric emptying. such rapid weight loss is a marker of deterioration of the nutritional status with increased risk of complications and reduced immunological barrier function. deterioration of the nutritional status also exacerbates side effects of the antiviral treatment like fatigue and depression. as a result, the quality of life of these patients may decrease. in the current controlled, prospective, multicenter, study we primarily aim to compare the effects of preventative versus on demand nutritional advice in combination with nutritional support on reduction of weight loss in patients receiving standard antiviral therapy with peg-interferon in combination with ribavirin. we will randomize patients for the preventative intervention with dietary consultation combined with dietary supplementation of a daily snack or the on demand dietary support group (only dietary follow up, no dietary advice or snack, standard care). in the on demand group, patients will be referred to the dietitian in case of weight loss of ≥ 5% or a bmi \< 20 during antiviral therapy. assuming that 60% reduction of weight loss during the first 24 weeks of treatment is clinically relevant, 2 x 25 patients need to be included (α=0.05, β=0.2: power=0.8 and a drop-out rate of 15%). primary aim is to assess whether the intervention can decrease the amount of weight loss during therapy.

Eligibility criteria:
inclusion criteria: * diagnosis of hepatitis c * indication for antiviral therapy * age \> 18 years * good understanding of dutch or english language * informed consent exclusion criteria: * co-infection with hepatitis b and/or hiv * significant non hepatic diseases * significant previous surgery of the gastro-intestinal tract * hepatocellular carcinoma or other current malignant disease * bmi \< 20

Keywords: hepatitis c antiviral therapy weight loss dietary support dietary advise
description of treatment patterns and population characteristics of pre-dialysis ckd patients in the czech republic

Conditions: Chronic Kidney Diseases

Summary: the decision making in the czech nephrology offices depends on the local common practice which is likely to be heterogenous. in other words, the same patient would be indicated to different therapy and regimen at different sites. to date, the practices and treatment paths have not been described. the aim of the present epidemiological research is to characterize the population of ckd patients at the point of treatment choice and to outline the motivation of nephrologist to initiate particular therapy.

this is epidemiological (observational) cross-sectional survey. data for the research will be obtained from clinical records and patient´s questionnaires and transcribed into electronic case report forms (ecrf) by physician anonymized using subject id. this observational research will not impose any additional procedures, assessments, or changes in addition to the routine management of subjects. the research does not aim to follow treatment with a single medicinal product. the management of patients will be described in general terms. names of active substances will be collected rather than the names of individual products.

Eligibility criteria:
inclusion criteria: * adult patient of 18 years and older * signed consent with processing of personal data as per the gdpr and the applicable national legal requirements * chronic kidney disease (ckd) category 4 to 5 characterized by gfr \< 30 ml/min/1.73m2 for at least 3 months exclusion criteria: * patients on chronic dialysis * patient waiting for kidney transplant * patient requiring indication of dialysis (e.g., life-threatening changes in fluid, electrolyte, and acid-base balance, serositis, pruritus, inability to control blood pressure, lethargy or other changes in mental status, symptoms of uraemia, gfr \< 10 ml/min/1.73 m2) * patient with altered mental state unable to fill patient questionnaires

Keywords: epidemiological survey renal failure decreased renal function dialysis low protein diet treatment alternatives clinical frailty scale mini nutritional assessment (mna) bansal score
effects of upper extremity immobilization and use of a steering wheel spinner knob following distal radius fracture

Conditions: Distal Radius Fracture

Summary: the aims of the study are to better understand how upper extremity injury and immobilization influences a patient's steering ability. patients with acute distal radius fractures treated with surgery will be recruited for study in a driving simulator. the results will hopefully assist physicians to better counsel patients with upper extremity injuries on when it is safe to return to driving.

the ability of an injured person to safely drive an automobile while immobilized in an upper extremity cast or splint is not well defined. the aims of the study are to better understand how upper extremity injury and immobilization influences a patient's steering ability. the secondary aim is to further evaluate the effectiveness of a steering wheel spinner-knob to assist with one-handed driving. a steering wheel spinner knob may be a surrogate to assist with one handed driving while immobilized.

Eligibility criteria:
inclusion criteria: * • acute distal radius fracture treated with surgery and initially immobilized in a cast or splint * valid driver's license with 1 years of driving experience and actively driving during the last three months * english speaking * ability to start testing within 10 days of surgery exclusion criteria: * • \<18 years of age * current use of steering wheel spinner knob or hand controls while driving * non-drivers * multi-trauma * open fractures * surgical repair with external fixation * concurrent distal radius/ulnar joint injury and repair * any other joint besides the wrist immobilized following surgery * contralateral upper extremity disability * previous ipsilateral upper extremity functional deficit * inability to participate for the full length of the study

Keywords: distal radius fracture steering steering wheel spinner knob
characteristic of play: comparison between children with development coordination disorder ( dcd) and children with typical development

Conditions: Development Coordination Disorder

Summary: there will be found differences in the issue of characteristic of play between children with development coordination disorder and children with typical development.


Eligibility criteria:
inclusion criteria: * children with proper( age expected) intelligence and iq level * study in regular education system * the dcd diagnosis must be confirmed by a pediatrician exclusion criteria: * score above 9 in the movement assessment battery test for children * score below 3.83 in children activity scale for parents * routinely take medication * any physical limitations * neurologic and/or muscle disease * any significant hearing and/ or vision limitations

Keywords: characteristic of play dcd children typical development whether there are any differences in the issue of characteristic of play between children with dcd and children with typical development
pk and food effect of pregabalin study after dosing in healthy male volunteers

Conditions: Peripheral Neuropathy Pain

Summary: this study is to assess the pharmacokinetics of pregabalin controlled release formulation after multiple dosing as compared to pregabalin immediate release formulation and the food effect of high fat diet after single dosing in healthy male volunteers.

cohort 1 study is to assess the pk of pregabalin controlled release formulation as compared to pregabalin immediate release formulation. cohort 1 subjects will be admitted to the clinic at day 1. all subjects will receive multiple dosing for three days of yhd1119 or pregabalin ir and will remain in the clinic until completion of all assessment on day 19 including collection of pk sample. the treatment periods were separated by a washout period (10-17 days). cohort 2 study is to assess the food effect of high fat diet after single dosing. cohort 2 subjects will be admitted to the clinic at day -1. all subjects will receive a single dose of yhd1119 and will remain in the clinic until completion of all assessment on day 9 including collection of pk sample. the treatment periods were separated by a washout period (7-14 days).

Eligibility criteria:
inclusion criteria: * healthy male with body mass index (bmi) between 18.5 and 28 kg/m2 * who has not suffered from clinically significant disease * provision of signed written informed consent exclusion criteria: * history of and clinically significant disease * a history of drug abuse or the presence of positive reactions to drugs that have abuse potential in urine screenings for drugs * administration of other investigational products within 3 months prior to the first dosing
effect of laser puncture versus ultraviolet radiation on women with polycystic ovarian syndrome

Conditions: Polycystic Ovary Syndrome

Summary: obese women with polycystic ovarian syndrome aged between 25 and 35 years old will be divided into three groups. for three months, group (a) will receive laser puncture (3 sessions per week), along with a metformin supplementation, group (b) will receive ultraviolet radiation (3 sessions per week), along with a metformin supplementation, while group (c) will receive only metformin supplementation. the follicular size will be measured using ultrasound, while, female sex hormones, and serum 25-hydroxyvitamin d levels will bel evaluated using blood analysis

obese women with polycystic ovarian syndrome aged between 25 and 35 years old will be divided into three groups. for three months, group (a) will receive laser puncture (3 sessions per week), along with a metformin supplementation, group (b) will receive ultraviolet radiation (3 sessions per week), along with a metformin supplementation, while group (c) will receive only metformin supplementation. the follicular size will be measured using ultrasound, while, female sex hormones, and serum 25-hydroxyvitamin d levels will bel evaluated using blood analysis

Eligibility criteria:
inclusion criteria: * obese nulli gravid pcos women * bmi 30-40 kg/m2 exclusion criteria: * hyperprolactinemia * bmi \> 40 kg/m2 endocrinological disorders such as thyroid disease, cushing's syndrome, coagulopathy * recent use of oral contraceptive pills * recent use of any photosensitizing medications, such as aspirin, tetracycline, chlorothiazide, or psoralen suspicious of neoplasms
effect of manual therapy on non specific neck pain

Conditions: Neck Pain

Summary: the aim of this study is to investigate the effects of mulligan concept reverse natural apophysial glide technique (rnags)technique applied to the thoracic region on pain, limitation of movement, and functionality in individuals with mechanical neck pain.

when we look at the studies investigating the effectiveness of different treatment modalities in non-specific neck pain (nsnp), there is no method accepted as the gold standard for the treatment of nsnp. one of the preferred treatment options for nsnp is physiotherapy and rehabilitation. physiotherapy and rehabilitation includes electrotherapy modalities, therapeutic exercises, joint mobilisation and manipulations, myofascial release. among these treatments, manual therapy, which targets the harmony of structure and function, is one of the most preferred treatment methods by physiotherapists. manual therapy provides improvement by orienting the body's biomechanics, circulation and body structure by directly affecting the joints, muscles and soft tissues. in the literature, there are studies on both cervical mobilisation and thoracic mobilisation for neck pain. cervical mobilisation and manipulation in neck pain are controversial because they carry certain risks. it has been reported that mobilisation of the thoracic spine decreases pain in the cervical region and increases mobilisation in this region. when the literature was examined, there was no study examining the effect of the mulligan concept natural apophyseal reversal technique applied to the thoracic region on nsnp. this study was planned to investigate the effect of natural apophyseal reversal on pain and mobility limitation in individuals diagnosed with nsnp.

Eligibility criteria:
inclusion criteria: * those between the ages of 18-65 * those with neck pain lasting at least 3 months * individuals diagnosed with mechanical neck pain by a specialist physician exclusion criteria: * those with a history of spinal surgery * those with a history of whiplash injury * those with a history of trauma in the cervical and thoracic region * pregnancy

Keywords: mechanical neck pain thoracic mobilization mulligan range of motion