Kornimate/medical-research-clean huggingface dataset:
immediate effects of different rates of thoracic mobilization on pressure pain thresholds in asymptomatic individuals

Conditions: Spine Stiffness

Summary: passive mobilizations of the spine are widely used by physiotherapists in the management of neuromusculoskeletal disorders. there is a nascent body of work of the mechanical properties of joint mobilizations. treatment dose is characterized by the direction of force applied, magnitude of force applied, frequency of oscillation, amplitude of displacement, repetition and time. although the choice of better treatment dose is based on patient complaints and clinical reasoning, the comprehension of the effects of different parameters of joint mobilization will improve the decision making process. the optimal dose of treatment, however, is not already known. the primary aim of this study is to determine whether different rates of thoracic mobilization are capable to produces hypoalgesic effects, and secondarily investigate if such effects are local or widespread.

healthy volunteers will be recruited and randomized into 3 groups. a 2hz mobilisation group, a 0,5hz mobilisation group and a placebo group. the pressure pain threshold will be measured before, immediately after and 15 minutes after the intervention.

Eligibility criteria:
inclusion criteria: * healthy asymptomatic subjects * manual therapy naive exclusion criteria: * any kind of history of trauma or surgery to the spine * contraindications or precautions to manual therapy

Keywords: spinal mobilisation pressure pain threshold thoracic spine
auriculotherapy neuroimaging

Conditions: Low Back Pain; Chronic Low-back Pain; Back Pain, Low; Lumbar Disc Disease; Lumbar Discogenic Pain; Lumbar Pain Syndrome; Lumbar Post-Laminectomy Syndrome; Back Pain Lower Back Chronic; Back Pain Without Radiation; Pain;Back Low;Chronic

Summary: this is a clinical study of patients who have low back pain (for at least 6 months). the goal is to understand, with brain imaging, how auriculotherapy (an acupuncture-like stimulation of the ear) may work to relieve pain. there are 4 total study visits, divided into two pairs of visits that occur before and 5-7 days after receiving either a real or sham auriculotherapy treatment. the cryo-iq device will be used, to stimulate 7 small areas on both ears with a focused jet of cold as a small amount of compressed gas is released. this is generally not painful, and less invasive, compared to using needles for auriculotherapy.

this is a 1:1 randomized, double-blind, sham-controlled, within-subject crossover trial of cyro-auriculotherapy in patients with chronic low back pain. cryo-auriculotherapy is an effective alternative to needles, in which compressed gas provides focal (\~1 mm2) persistent stim of auricular points, with minimal pain. both before and 5-7 days after (time of peak effect) active vs. sham cryo-at, resting brain connectivity will be measured with functional mri and responses to a non-therapeutic experimental auricular stim paradigm (using von frey filaments) will be recorded with functional near infra-red spectroscopy. after a 2-month washout period, patients will return for the same data collection surrounding the crossover intervention.

Eligibility criteria:
inclusion criteria: 1. adult, at least 18 years old 2. episodes of chronic low back pain at least daily for at least 6 months, with an average pain score within the last week of 3/10. exclusion criteria: 1. active lesions, skin disruptions, or neuropathy of either ear; 2. recent (\<1 month) analgesic procedures or surgery; 3. recent (\<1 month) start of new analgesic or psychoactive medication (including marijuana, opioids, tramadol, methadone, gabapentinoids, anti-depressants, anti-epileptics, mood-stabilizers, anti-psychotics, or stimulants); 4. history of chronic pain in shoulder or thumb (to avoid confounding at control stimulation points); 5. recent (\< 3 months) illicit drug use; 6. prior substance misuse/abuse; 7. cold-activated diseases (including: agammaglobulinemia, cold urticaria, cold agglutinin disease, cryofibrinogenemia, cryoglobulinemia, immunosuppression, raynaud's disease, collagen or autoimmune diseases, multiple myeloma, platelet deficiency disorders, pyoderma gangrenosum.) - mri-specific exclusions additionally include: 8. pregnancy or active attempts at conception; 9. implanted metal or electronic device; 10. severe claustrophobia

Keywords: auriculotherapy auricular stimulation functional near-infrared spectroscopy functional magnetic resonance imaging functional connectivity cryo-auriculotherapy
treatment of acute tracheitis and laryngitis with essential oils of aromatic plants

Conditions: Viral Laryngitis; Viral Tracheitis

Summary: this randomized, double blind, parallel group study, compared the efficacy of spray containing aromatic essential oils of some herbal plants, against placebo in the treatment of patients with acute viral laryngitis or tracheitis. study objectives: primary to demonstrate a hoarseness or cough relief within 20 minutes after first administration of treatment with the spray. secondary to demonstrate a reduction of a defined symptoms sum score based on symptoms and signs comparing baseline therapy from the beginning to the end of 3 days treatment

this study compared the efficacy of spray containing aromatic essential oils of eucalyptus citriodora, eucalyptus globulus, mentha piperita, origanum syriacum, and rosmarinus officinalis, against placebo in the treatment of patients with acute viral laryngitis or tracheitis. in- vitro and clinical studies suggest therapeutic potential of aromatic herbs and trees oils in the treatment of laryngitis or tracheitis. the pharmacological and clinical activity of eucalyptus citriodora, eucalyptus globulus, mentha piperita, origanum syriacum, and rosmarinus officinalis, include anti-inflammatory, anti-bacterial and anti-viral activities. some of these herbs and trees oils have direct activity on the respiratory tract, the coughing reflex and the airflow in the nasal tract.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of acute viral laryngitis or viral tracheitis. * active disease less than 48 hours * patients agree to sign informed consent according to gcp and israel national regulations. exclusion criteria: * acute lower respiratory tract infection. * c.o.p.d.(chronic obstructive pulmonary disease) * under any antibiotically treatment. * asthma disease. * under coumadine therapy. * hyper sensitivity to aromatic essential oils. * any immuno-suppressive disease

Keywords: viral laryngitis; viral tracheitis; herbal medicine; traditional medicine; aromatic essential oils;
effect of short peripheral electrical stimulation (pes) on blood glucose

Conditions: Type 2 Diabetes Mellitus

Summary: the epidemic nature of type 2 diabetes mellitus, along with the downsides of current treatments, has raised the need for therapeutic alternatives. the aim of this study is to evaluate safety, tolerability, and the glucose-lowering effect of noninvasive peripheral electrical stimulation (pes) as an alternative treatment for diabetes.


Eligibility criteria:
inclusion criteria: * patients diagnosed with type ii diabetes, for at least one year prior to randomization * body mass index bmi \< 35 kg/m2 * stable glucose lowering drugs regimen for at least one month prior to randomization * capable of giving informed consent exclusion criteria: * pregnancy, or nursing * 10\< hba1c \< 6 * permanent pacemakers * metal prosthesis * resting blood pressure \> 160/ 100 mmhg * skin disease * treatment with steroids or beta-blockers treatment with psychiatric medications
improving cancer survival and reducing treatment variations with protocols for emergency care

Conditions: Cancer

Summary: significant challenges and gaps remain in navigating transitions between acute care and outpatient care for many cancer survivors. this study underscores 1) implementation of emergency department (ed) risk-stratified treatments protocols that standardize patient care and would allow for rapid re-assessment and access to specialist care with well-coordinated cancer care plans, and 2) the significant numbers of minority cancer survivors seeking episodic care in the ed that are at increased risk of not receiving recommended post cancer treatment surveillance.

the over-arching goal of this study is to develop a portable model for ed cancer treatment guidelines and management using evidence based protocols in a population at high risk for poor cancer -related outcomes by identifying \& overcoming specific barriers to enhanced survivorship. based on the demographics of ed population (currently, 70% racial/ethnic minorities), the majority of participants will be underrepresented (african-american and hispanic) and low-income individuals. the investigators propose a feasibility study of 150 patients in the ed over a 1 year period. the specific aims are: aim 1: evaluate the effectiveness of ed risk-stratified, evidence-based treatment protocols on the primary outcome of ed utilization rates and subsequent acute inpatient admissions at 6 -months post-intervention. aim 2: evaluate the effectiveness of an ed-based cancer patient navigator on the secondary outcomes of patient engagement and primary care engagement at 6 -months post-intervention. aim 3: examine barriers and facilitators to compliance for cancer survivorship recommendations that occur in an ed setting at 6-months post intervention.

Eligibility criteria:
inclusion criteria: * cancer survivor (has had cancer in their lifetime, and is currently disease-free) * verbal fluency in english or spanish * age 18-75 years exclusion criteria: * unable to verbalize comprehension of study or impaired decision making (e.g., dementia) * plans to move from chicago area within the next year
relationship between footwear consumer behaviour and lower extremity injuries

Conditions: Risk Factor; Sports Injury; Footwear

Summary: a prospective cohort study was set-up in leisure-time walkers and runners. potential risk factors in consumer behaviour were obtained by means of a baseline questionnaire related to the acquisition of current walking or running shoes. information on injuries sustained during a 24 week period after the baseline questionnaire was obtained in 104 runners and 104 walkers using a 2-weekly questionnaire.


Eligibility criteria:
inclusion criteria: * walk or run at least 10 kilometres per week * maintain a minimal distance of ten kilometres per week, for a period of 24 weeks * wear one and the same pair of shoes during walking/running activities during this period exclusion criteria: * systemic disease, cardiac problems or diabetes * complaints at the lower extremities in the last two weeks, * surgery at the lower extremities in the last three years
valsartan in cardiovascular disease with renal dysfunction (the v-card) study

Conditions: Hypertension

Summary: the purpose of this study is to investigate if an angiotensin ii receptor blocker, valsartan 160 mg/day is more effective to reduce the incidence of cardiovascular events as compared to 40 mg/day in patients with moderate renal dysfunction.

it is well known that patients with renal dysfunction have a poor prognosis concerning cardiovascular diseases. that is called "cardiorenal syndrome". it was reported that valsartan was effective in reducing the urine albumin extraction rate in patients with hyper- or normotension. we hypothesized that valsartan was more effective to prevent cardiovascular events by the intermediary of improving renal function. the primary endpoints are: * cardiovascular events (cardiac death, non-fatal myocardial infarction, unstable angina requiring rehospitalization, congestive heart failure requiring rehospitalization, revascularization procedures including coronary angioplasty or coronary artery bypass grafting;stroke or transient ischaemic attack, dissociation aneurysm of the aorta needing hospitalisation;lower limbs artery obstruction needing hospitalisation . * end-stage renal dysfunction (introduction of hemodialysis or kidney transplantation) * 50% reduction of creatinine clearance the secondary endpoints are: * systolic and diastolic function of the left ventricle estimated by echocardiography (% fs and e/a ratio) * specific biochemical markers for cardiac or renal function (urine microalbumin, plasma b-type natriuretic peptide, plasma type 1 plasminogen activator inhibitor, plasma cystatin c) * % changes of creatinine clearance between start and end of the study period * transition of 1/(serum cr) in patients whose u-prot/u-cr is equal to or more than 1.0 * transition of serum k * hba1c * new onset atrial fibrillation * new onset diabetes

Eligibility criteria:
inclusion criteria (all required): * systolic blood pressure (sbp) \>/= 140 and/or diastolic blood pressure (dbp) \>/= 90 (untreated hypertension cases); or sbp\>/=130 and/or dbp\>/=80 (treated hypertension cases) * patients with coronary artery disease (more than 50% stenosis on coronary angiography \[cag\], coronary computed tomography \[ct\] or coronary magnetic resonance angiography \[mra\]; coronary spasm; or history of percutaneous coronary intervention \[pci\]);unstable angina patient * creatinine clearance between 30.0 and 89.9 ml/min exclusion criteria (at least one of following): * reduced left ventricular (lv) function (ejection fraction \[ef\] equal to or less than 40%) * hyperpotassemia (serum potassium equal to or more than 5.5 meq/l) * rapid progressive glomerular nephritis * nephrotic syndrome * renal artery stenosis * uncontrolled diabetes (hba1c equal to or more than 9.0%) * history of allergy to valsartan * pregnant women

Keywords: cardiorenal syndrome renal dysfunction cardiovascular events valsartan
efficacy and safety assessment of ire of localized prostate cancer

Conditions: Prostate Cancer; Prostate Adenocarcinoma

Summary: the purpose of this study is to evaluate safety and short-term oncological efficacy of the nanoknife irreversible electroporation system for localised prostate cancer. irreversible electroporation (ire) is the method of focal treatment for prostate cancer, which is already proven by fda as method of the surgical ablation of soft tissue. it has not received clearance for the therapy or treatment of any specific disease or condition.

detailed description: irreversible electroporation is a newly developed non-thermal tissue ablation technique in which short duration electrical fields are used to form permanent nanoscale defects in the cell membrane which leads to cell apoptosis. thus, ire is a non-thermal technique, which means that changes associated with tissue freezing or heating are not relevant. moreover, animal studies of ire in the canine prostate have demonstrated that structures such as ejaculatory ducts, neurovascular bundles, blood vessels, and the urethra heal normally after ablation. the reason is that collagen matrix during treatment with ire is not destroyed thus allowing for a large structures (blood vessels, nerves, etc.) to heal normally. this study is a prospective and non-randomized with one group of 12 patients eligible for focal therapy of prostate cancer with ire (eligibility defined by this protocol). before the surgery all patients will underwent transperineal mri-fusion biopsy to localize the prostate cancer foci. objectives of the study: to asses safety of ire in patients with localized pca, to asses short-term oncologic efficacy of ire in patients with localized pca, to asses functional outcomes after ire. all patients will be followed up for 1 year (each 3 months).

Eligibility criteria:
inclusion criteria: * verified with mr-fusion biopsy localized pca * psa \< 20 ng/ml * gleason score 3+3=6; 3+4=7 or grade group 1 and 2 * life expectancy \> 10 years * no post-void residual urine or infravesical obstruction exclusion criteria: * patients with artificial cardiac pacemaker * patients not eligible for general anesthesia * patients after primary pca treatment * hormonal therapy six months before the study * radiotherapy of pelvic organs * urinary infection * extracapsular pca * patients with metastatic lesions

Keywords: prostate irreversible electroporation prostate cancer
efficacy of hydroxycinnamates and beta-glucans as a dietary tool against obesity_pilot study (obhealth_ps)

Conditions: Overweight and Obesity

Summary: randomized, double blind, parallel study to assess the effect of a dietary supplement combining polyphenols (hydroxycinnamates from green coffee) and a soluble dietary fiber (oat beta-glucans) in obese/overweight subjects.

this pilot study intends to select the best combination of beta-glucan and a green coffee bean phenolic extract. four different supplements were formulated, containing 3 or 5 g of two types of beta-glucan, with 35% and 70% b-glucan content, together with 600 mg of the green coffee bean extract. blind sachets were prepared containing half the daily dose of the supplement. 60 overweight/obese male and female volunteers (bmi 25-35 kg/m2, 18-60 y old) were recruited and randomly assigned to one of the four intervention groups. volunteers were instructed to consume one sachet half an hour before lunch and dinner dissolved in 250 ml water daily during 6 weeks. at the beginning and at the end of the study, volunteers came to the human nutrition unit at the research center after an overnight fast. urine and blood samples were obtained, blood pressure was measured and anthropometric measurements were performed. dietary and physical activity records were collected.

Eligibility criteria:
inclusion criteria: * overweight/obese subjects (bmi 25-35 kg/m2) exclusion criteria: * smokers * pregnant women * medication/consumption of vitamins, dietary supplements, etc.

Keywords: hydroxycinnamates beta-glucan green coffee bean extract dietary supplement
natural history and nonoperative management of penetrating cerebrovascular injury

Conditions: Cerebrovascular Trauma

Summary: the goal of this study is to evaluate a series of cases of penetrating cerebrovascular injury managed without upfront operation. investigators focus on patient characteristics, injury details, treatment modalities, serial imaging studies, patient outcomes, and complications. investigators will compare this patient population to patients managed with upfront operation for context.

penetrating cerebrovascular injuries (pcvis) are uncommon, with little data to guide management when emergent operative repair is not performed. investigators hypothesized that pcvis may be managed with antithrombotic therapy and directed use of endovascular interventions, but that pcvis may require enhanced surveillance due to a risk of delayed complications. to perform this study, investigators will review patients with penetrating carotid and vertebral artery injuries managed at an urban level i trauma center from 2016 to 2022. patients will be included if they underwent initial nonoperative management (nom). patient characteristics, injury details, treatments, serial imaging, outcomes, and complications will be assessed in a retrospective manner using chart abstraction. investigators will briefly compare these patients to those managed with upfront operations for context.

Eligibility criteria:
inclusion criteria: * penetrating neck trauma * carotid or vertebral artery injury

Keywords: penetrating cerebrovascular injury nonoperative management penetrating neck trauma natural history antithrombotic therapy case series
combined peng and lfcn block for total hip arthroplasty

Conditions: Anesthesia, Conduction; Pain, Postoperative; Arthroplasty, Replacement, Hip

Summary: a clinical trial investigating the effect of a combined locoregional anesthesia technique on the postoperative analgesia outcomes after a total hip arthroplasty. a peng block will be used in combination with a lfcn block. the results will be compared to a control group that is solely treated with intravenous analgesia. this technique aims to provide improved pain scores after surgery without interference of revalidation.


Eligibility criteria:
inclusion criteria: * adult patients who underwent a primary total hip replacement under general anesthesia exclusion criteria: * insulin dependent diabetes mellitus * chronic pain * severe dementia or mental retardation * allergy to local anesthetics

Keywords: regional anesthesia postoperative pain total hip arthroplasty pericapsular nerve group block
follow-up study of small-intestinal mucosal injuries in chronic non-steroidal anti-inflammatory drugs (nsaids)-users

Conditions: Enteropathy

Summary: the purpose of this study is to evaluate the long-term clinical significance of small-intestinal mucosal injuries in chronic nsaids-users.


Eligibility criteria:
inclusion criteria: * written informed consent * 20 to 85 years of age * ra, oa, or low back pain * taking oral diclofenac sodium over 3 months * no change of drugs before 3 months * under 5 mg of corticosteroid use * crp \< 1mg/dl exclusion criteria: * known or suspected small-bowel disease, including crohn's disease and seronegative arthritis * prostaglandins, metronidazole or salazosulfapyridine * can not swallow * with pacemaker * after gastrointestinal operation * serious concomitant cardiovascular, endocrine, gastrointestinal(including symptoms of ileus), neurologic, psychiatric, renal, or respiratory disease. * any other conditions that the investigator feels would interfere with data interpretation or create under risk
telomeres and t-cell receptor excision circles (trecs) from peripheral blood in normal subjects over time

Conditions: Telomere Length in Healthy Controls

Summary: the investigators have established a cohort of patients with recent-onset inflammatory arthritis called early undifferentiated polyarthritis (eupa). this cohort was established to define novel biomarkers of poor outcomes. we want to study telomere length and t-cell receptor excision circles (trec) numbers in peripheral blood as new biomarkers. this cohort of normal controls was established to be able to define the stability over short periods of time of telomere length and trec numbers in normal individuals, in order to compare with arthritis patients.

it is difficult to establish early on the prognosis of patients with recent-onset polyarthritis. we want to know if we can use the length of telomeres in peripheral blood cells at baseline as a novel prognostic marker. in order to be able to interpret our observations in arthritis patients over time, we need to compare these results with those observed in normal human controls adjusted for gender and for age groups. these patients are first screened for the presence of acute or chronic severe diseases (cancer, cardiovascular, articular, et...). they then have genomic dna extracted from peripheral blood at baseline and at 3 months interval for a year than annually for a total duration of 5 years. a complete blood count is collected at each blood draw. at each blood draw, the appearance of acute or chronic diseases is noted.

Eligibility criteria:
inclusion criteria: healthy-for-age subjects, as defined by absence of acute infectious, traumatic or immunologic disease; absence of severe chronic diseases age and sex concordant with the stratification of patients from a longitudinal cohort of early inflammatory arthritis (eupa) exclusion criteria: history of cancer (except a single episode of non-melanocytic skin cancer) severe cardiovascular disease (i.e. difficult to control or requiring multiple drugs) chronic infection inflammatory arthritis severe high blood pressure or diabetes (i.e. difficult to control or requiring multiple drugs) any severe disease affecting function or difficult to control or requiring multiple drugs

Keywords: telomere length longitudinal observation