Kornimate/medical-research-clean huggingface dataset:
investigation of immediate efficacy of kinesiology taping

Conditions: Postural; Defect

Summary: shoulder protraction is the forward tilt of the head with hyperextension of the cervical spine and is associated with lengthening of the sternocleidomastoid and scalene muscles. with the lengthening of the flexor muscles, the weakened and shortened trapezius, levator scapula, and serratus anterior muscles lead to extra flexor torque and sustained contraction.

weakness in the rotator cuff muscles, especially infraspinatus and supraspinatus muscles, has been observed in individuals with scapular dyskinesia and who frequently use overhead movements in their daily lives. the most important point to be considered in the treatment of scapular dyskinesia is the effective evaluation and treatment of primary and secondary symptoms and conditions. the preference of shoulder rehabilitation programs in which the scapula is also included in the treatment program will provide great benefits to physiotherapists in terms of treatment. effective treatment can be provided by taping, exercise and many other treatment methods.

Eligibility criteria:
inclusion criteria: * those with neck pain * being between 18-60 years old exclusion criteria: * hypertension * cardiopulmonary disease * pregnancy * malignancy * operation, injection, etc. for the neck in the last 3 months. those with a history of treatment * spine surgery * psychological discomfort * neurological and orthopedic deficits

Keywords: taping
detection and management of non-compressible hemorrhage by vena cava ultrasonography

Conditions: Trauma; Wounds and Injuries

Summary: this is a study of patients admitted with major traumatic injuries. such patients may develop inadequate circulation to the organs as a result of internal blood loss. early detection of internal blood loss can be difficult as physical examination alone may miss patients with significant blood loss. some patients with internal bleeding will arrive with low blood pressure; these patients are usually given 2 liters of intravenous fluid to determine if their blood pressure will recover. if the blood pressure does not rise or if it drops again later, the blood loss can be assumed to be severe, and the patient will likely need transfusions, surgery and other interventions. however, this fluid treatment method can lead to delays and complications as some patients may initially respond but then continue to bleed. the inferior vena cava (ivc) is the large vein draining blood from the lower body to the heart. the inferior vena cava is known to empty when the patient has had significant blood loss. the vena cava diameter can be seen using ultrasound. this study intends to perform ultrasound to examine the vena cava diameter on patients just after arriving with major trauma. the hypothesis of the proposed study is that an ultrasound assessment protocol of inferior vena cava diameter and collapsibility can detect and aid management of non-compressible hemorrhage in major trauma victims. after the patient has been given the 2 liter intravenous fluid treatment, the inferior vena cava diameter will be measured again. a third examination 8-24 hours after admission will determine if the inferior vena cava diameter has returned to normal. we propose that measuring the inferior vena cava in this manner can predict those patients who are likely to continue bleeding and require interventions such as surgery. early detection in these patients may avoid delays in treatment, complications and excess mortality. because this examination is done with handheld ultrasound machines, it could be done outside hospitals and in military combat casualty care.


Eligibility criteria:
inclusion criteria: * major trauma patients brought to level i trauma centers. * selected patients for the study will be those presenting with ivc collapsibility \> 50% on modified-fast at admission and/or * ivc diameter of \< 12mm on modified fast at admission and/or * a non-visualized ivc due to total collapse on modified fast at admission (not due to body habitus or inadequate ultrasonography technique) exclusion criteria: * pregnancy after 20 weeks gestation * those under 18 years of age * prisoners and others prohibited from participating in clinical trials * patients with severe traumatic brain injury who at admission are deemed by treating surgeons as having non-survivable brain injuries

Keywords: trauma ultrasound shock resuscitation
amyloid imaging and safety study of subcutaneous bapineuzumab in subjects with mild to moderate alzheimer's disease

Conditions: Alzheimer's Disease

Summary: this study in individuals with mild to moderate alzheimer's disease is designed to assess:(1) safety and tolerability (2) the capacity of subcutaneous bapineuzumab to reduce brain amyloid load as measured by positron emission tomography (pet) scans.


Eligibility criteria:
inclusion criteria: * diagnosis of probable ad * age from 50 to less than 89 * mini-mental status exam score of 18-26 inclusive * brain magnetic resonance imaging (mri) scan consistent with the diagnosis of ad * stable doses of medications (cholinesterase inhibitors and memantine allowed) * caregiver able to attend all clinic visits with patient * amyloid burden on screening pet scan consistent with diagnosis of ad exclusion criteria: * significant neurological disease other than ad * major psychiatric disorder * significant systemic illness * history of stroke or seizure, autoimmune disease, myocardial infarction within the last 2 years * smoking greater than 20 cigarettes per day * anticonvulsants, anti-parkinson's, anticoagulant, or narcotic medications * prior treatment experimental immunotherapeutics or vaccines for ad * women of childbearing potential * presence of pacemakers, csf shunts, or foreign metal objects in the eyes, skin or body
study of the association of nonalcoholic fatty liver disease with colorectal malignant neoplasm

Conditions: Colorectal Neoplasms; Nonalcoholic Fatty Liver Disease

Summary: the aim of this sudy is to investigate the prevalence of colorectal cancer (crc) in patients with nonalcoholic fatty liver disease (nafld) and evaluate whether nafld is a risk factor for crc.

as one of the most common cancer worldwide, colorectal cancer (crc) is a major cause of cancer death in asian countries. and during the past three decades, the incidence of crc has been increasing rapidly in china. many studies supported that cigarette smoking, obesity and insulin resistance were associated with crc. in recent years, metabolic syndrome (mets) - including glucose tolerance, dyslipidemia, obesity, hypertension and chronic inﬂammation - and its individual components have been proven to be the risk for colorectal neoplasm. colonoscopy is the most accurate technique for diagnosis, surveillance and exclusion of colorectal neoplasm for high-risk crc groups. therefore, improved risk stratiﬁcation knowledge of the target population is necessary to improve crc patients' prognosis. nonalcoholic fatty liver disease (nafld) is the most prevalent chronic liver disease worldwide and cause a wide spectrum of liver damage, such as steatohepatitis, cirrhosis, even end-stage liver disease and hepatocellular carcinoma. nafld has been found to be associated with obesity, insulin resistance, hypertension and dyslipidemia, and is considered as a liver manifestation of mets. although it has been also well established that mets and its individual components are risk factors for colorectal neoplasm, as above, there is paucity of research looking at the relation between nafld and crc. therefore, the investigators aimed to investigate the prevalence of crc in patients with nafld and evaluate whether nafld is an independent risk factor for crc.

Eligibility criteria:
inclusion criteria: * patients had colonoscopy and * patients had conventional inspections(blood routine, liver function test and abdomen b ultrasonography) exclusion criteria: * patients were excluded with history of colorectal cancers or polyps, other extraintestinal malignancies and contraindications to colonoscopy. * patients were excluded who had viral hepatitis, cirrhosis, liver cancer or other liver disease. * patients ere excluded who drank more than 20g alcohol per day.
safety and effectiveness of giving isotretinoin to hiv-infected women to treat cervical tumors

Conditions: HIV Infections; Cervix, Dysplasia

Summary: the purpose of this study is to see if it is safe and effective to give isotretinoin to hiv-infected women with cervical tumors to prevent these tumors from becoming cancerous. cervical tumors are found in both hiv-infected and hiv-negative women. however, hiv-infected women are at a greater risk, and often their tumors become cancerous more quickly than those in hiv-negative women. isotretinoin may be able to prevent this from happening. however, since these tumors tend to disappear over time, many doctors are hesitant to give their patients isotretinoin since this drug causes birth defects. this study looks at whether it is better to treat cervical tumors in hiv-infected women or to wait and see if they will disappear by themselves.

cervical neoplasia is frequently seen in hiv-infected women, apparently resulting from immunosuppression and common risk factors, including sexual behavior patterns. in hiv seronegative women, progression of preinvasive neoplasia is relatively slow, and up to 40 percent of low grade squamous intraepithelial lesions (grade i cin/hpv-associated changes) regress to a normal appearance over time. many clinicians have opted not to treat cin i/hpv-associated changes due to this high spontaneous regression rate. currently, retinoids, principally isotretinoin, are the most consistently effective medical therapy for cin/hpv-associated changes, but use of isotretinoin in hiv-infected patients has not been extensively documented. (as per amendment 6/10/97) patients are randomized to receive oral isotretinoin for 6 months or be observed only for 6 months, with 12 additional months of follow-up. \[as per amendment 7/23/99: follow-up time has been decreased to 9 months from the last patient enrolled.\]

Eligibility criteria:
inclusion criteria you may be eligible for this study if you: * are an hiv-positive female. * are at least 13 years old. (need consent of parent or guardian if under 18.) * have cervical tumors, as determined by a biopsy performed by a doctor. * agree to use both condoms and the pill during the study. exclusion criteria you will not be eligible for this study if you: * have received certain cancer therapies (such as chemotherapy) within the past 3 or 4 months. * have had a hysterectomy (uterus removed) within the past 4 months. * are taking tetracycline or vitamin a. * have taken certain medications. (approved anti-hiv drugs and medications to prevent aids-related opportunistic infections are okay.) * are pregnant.

Keywords: acquired immunodeficiency syndrome aids-related complex cervix dysplasia cervix diseases isotretinoin cervical intraepithelial neoplasia cervix neoplasms keratolytic agents
validation of multimodal evoked potentials (mmep) for predicting disease progression in multiple sclerosis

Conditions: Multiple Sclerosis

Summary: utility of multimodal evoked potentials (mmep) for monitoring disease course and prediction of progression at different stages of multiple sclerosis (ms) is investigated


Eligibility criteria:
inclusion criteria: * diagnosed with a clinically isolated syndrome (cis) or ms with a relapsing-remitting (rrms) or a primary progressive disease course (ppms): * cis: edss \<= 5.5 within six months of first clinical event * early rrms: edss: \<= 3.5 disease course of 5 up to 10 years * late rrms: edss: 2.0-5.5 inclusive disease course of 5 to 15 years * ppms: edss: 2.0-6.5 inclusive disease course up to 15 years * participation in the swiss multiple sclerosis cohort study (smsc) * mental ability to cooperate * written informed consent exclusion criteria: * alcohol or substance abuse * progressive disease other than multiple sclerosis * psychiatric disorder requiring a treatment by a psychiatrist * patients with movable metal implants, e.g. pace-maker, stents, deep brain stimulators etc.;(patients with jaw- or bone-fixed metal implants can be included)

Keywords: multimodal evoked potentials visual evoked potentials somato-sensory evoked potentials motor evoked potentials expanded disability status scale (edss)
virtual reality for neglect diagnostics

Conditions: Spatial Neglect; Stroke

Summary: compared to the classical "paper and pencil"-tests, testing patients in our virtual reality setup might have a higher sensitivity and specificity.


Eligibility criteria:
inclusion criteria for neglect patients: * age ≥18 and \<80 years * first stroke * neglect symptoms * no hemianopsia symptoms * consent given by the patient inclusion criteria for hemianopsia patients: * age ≥18 and \<80 years * first stroke * no neglect symptoms * hemianopsia symptoms * consent given by the patient inclusion criteria for controls: * age ≥18 and \<80 years * no neurological deficits * informed consent exclusion criteria (for all groups): * language comprehension deficits * motor deficits of the upper extremities * cognitive impairments (mmse \ 15 or demtec \>12) * depression * seizure disorders * claustrophobia

Keywords: stroke neglect hemianopsia virtual reality
multicentric risk evaluation of autologous fat grafting procedure

Conditions: Pain, Postoperative

Summary: autologous fat grafting, also known as lipofilling, is a surgical technique consisting in the processing and transfer of adipose tissue from one area in our organism (hips, thighs) to region which in need of reconstructive and aesthetic correction. the technique is frequently used after radical or conservative mammary surgery, aiming to achieve better aesthetic results, reduce pain induced by both surgery and radiotherapy. the scientific community was widely involved in the debate regarding the use of mesenchymal/stem cells in a patient with high risk of tumor progression due to their elevated proliferative profile. this study aims to retrospectively evaluate the oncological safety in the use of lipofilling in patients who underwent oncological and reconstructive treatment in our institute.


Eligibility criteria:
inclusion criteria: * female * breast carcinoma (any histological type, carcinoma in situ included) treated with radical or conservative surgery * group treated with lipofilling and group which didnt receive lipofilling * timing: retrospective evaluation of cases form 2006 to 2016, with a minimum of two year follow up exclusion criteria: * neoplasie different from infiltrating and in sutu breast carcinoma * in situ lobular carcinoma * patients with breast carcinoma and metastasis * lipofilling procedure used before the oncological treatment for breast carcinoma

Keywords: autologous fat grafting lipofilling breast cancer breast reconstruction
the effect of fractional co2 laser either with tacrolimus, calcipotriol or nb-uvb in stable generalized vitiligo

Conditions: Vitiligo Vulgaris

Summary: vitiligo is an acquired disorder of the skin and mucous membranes characterized by well circumscribed depigmented macules and patches that occur secondary to selective destruction of melanocytes (zhang et al., 2009). generalized vitiligo is the most common clinical presentation and often involves the face and acral regions (alikhan et al., 2011).

combined vitiligo treatments have been found to be superior to monotherapies regarding efficacy, early response and safety (kandaswamy et al., 2013). fractionated lasers represent a new modality for skin resurfacing based on the theory of fractional photothermolysis introduced by manstein et al (2004). these lasers were shown to be efficient in treating facial photo aging changes as well as scars, and have an improved safety and recovery profile compared with traditional co2 laser resurfacing. fractionated lasers do not ablate the entire epidermis and thereafter leave intact skin between coagulated necrotic columns. this characteristic facilitates the skin healing process (bogdan et al., 2010)

Eligibility criteria:
inclusion criteria: * patients with stable vitiligo * nonsegmental vitiligo will be recruited * a patient reporting no new lesions, no progression of existing lesions, and absence of koebner phenomenon during the previous year exclusion criteria: 1. patients with active infection. 2. reported histories of koebnerization. 3. history of keloid formation or hypertrophic scars. 4. pregnant or lactating females. 5. bleeding tendency.
acute effects of static stretching on the knee joint position sense of soccer players

Conditions: Healthy

Summary: the aim of this study was to investigate the acute effects of static stretching on the knee joint-position sense of soccer players.

this crossover randomized controlled trial included male soccer players. all participants performed 3 conditions: two experimental conditions, of static stretching of the quadriceps and hamstrings muscles, for 30 or 90 seconds; and a control condition (rest). knee joint-position sense of the dominant limb was assessed before and immediately after the conditions for the range of 45º of knee flexion by active repositioning, using a video camera. absolute, relative and variable angular errors were calculated.

Eligibility criteria:
inclusion criteria: * male soccer players * aged between 18 and 30 years old * with normal knee range of motion * without history of lower limb injuries in the last 6 months exclusion criteria: * history of knee surgery * with cardiorespiratory, neurological or vestibular diseases * with positive knee integrity tests (anterior drawer, posterior drawer, lachman test and valgus and varus stress tests) * using drugs that could affect the central nervous system, balance, or motor control (sedatives, anxiolytics, analgesics, nsaids, muscle relaxants, or antibiotics).

Keywords: static stretching joint position sense proprioception knee soccer
prognosis and diagnosis of spasticity in acute-post stroke patients

Conditions: Stroke, Acute; Stroke, Ischemic; Stroke Hemorrhagic; Spasticity as Sequela of Stroke

Summary: spasticity, or greater muscle resistance, is a major disabling condition following stroke. recovery of lost motor function in patients with stroke may be affected by spasticity, which most commonly develops in elbow and ankle muscles. however, despite its clinical relevance, the natural development of spasticity over the first 3 months after stroke is not clearly understood. indeed, common clinical measures of spasticity such as the modified ashworth scale (mas) do not take into account the neurophysiological origin of spasticity and lack reliability and objectivity. the objective of this study is to examine the natural history of the development of spasticity among patients with stroke over the first 3 months using a new neurophysiological measure (tsrt, the tonic stretch reflex threshold angle) and its velocity sensitivity (mu) in comparison to mas and other common clinical tests. in addition, detailed brain imaging will be used to understand the relationship between damage to brain regions relevant to the development of spasticity and tsrt/mu values. it is hypothesized that 1) tsrt/mu will indicate the presence of spasticity earlier than mas/clinical tests; 2) tsrt/mu measures will be more closely related to motor impairments and activity limitations than mas; 3) the lesion severity (identified by imaging) will be related to the change in tsrt/mu values. outcomes will be measured in a pilot cohort of 12 patients hospitalized for first-ever stroke. measurements will be taken at the bedside within the 1st week of the patient's admission and will be done once per week for 12 weeks with a follow-up at week 16. brain imaging will be done around the 6th week post-stroke.


Eligibility criteria:
inclusion criteria: * acute stroke in middle cerebral artery area resulting in hemiparesis. * hemorrhagic or ischemic * medically stable * able to provide informed consent exclusion criteria: * severe cognitive disorders * ataxia

Keywords: stroke spasticity imaging prognosis diagnosis upper limb lower limb
collecting the results of multiple trauma patients and find the correlation of morality and mobility

Conditions: Multiple Trauma/Injuries

Summary: collect data about physiological examination values, blood test values and radiological examination results of patients admitted to the hospital for major trauma. there are different causes of mortality in multiple trauma patients. in this study, review the multiple symptoms and parameters of major trauma patients. we hope to understand and develop one feasible assessment model for emergency departments for enable rapid diagnosis and treatment evaluation about major trauma patients occurrence.

1. this is a retrospective study of patients admitted to the emergency department at a single center, focusing on reviewing their medical records and patient examination performance. 2. the parameters including hospital on-site records and patient examination result, physiological examination values, blood test values and radiological examination results.on the medical records of patients who visited emergency department are collected. 3. this study will explore how to improve the response and effectiveness of investigating patients when they are admitted to the hospital for major trauma. 4. evaluate the effectiveness and efficiency of this operative model to increase the possibility of receiving medical examination, timely correct diagnosis on major trauma patients when they sent to the emergency department, and improve the hospital's manpower deployment plan.

Eligibility criteria:
inclusion criteria:multiple trauma patients - exclusion criteria:expired patients at emergency room -

Keywords: trauma physical parameter radiologic examination
comparison of sample biopsy using scalpel or er:yag laser

Conditions: Laser Burn; Gingival Disease; Biopsy Wound

Summary: for certain changes in the oral mucosa a histopathological examination of the affected tissue is indicated to confirm the diagnosis. the gold standard is the biopsy by scalpel. the aim of this study is to compare the alternative method of tissue sampling using the erbium doped yttrium aluminium garnet (er:yag) laser with the gold standard.

various parameters are compared, such as the pain intensity during and after the biopsy, the evaluation of the tissue removed by the histopathologist, the occurrence of bleeding during and after the removal and the time required for both therapies. patients who agree to participate in the study will be randomized (randomly) to either therapy.

Eligibility criteria:
inclusion criteria: * indication for biopsy of the oral mucosa * male and female adult patients * written consent of the participating persons after clarification exclusion criteria: * pregnancy * taking blood thinners * known infectious diseases * untreated diabetes mellitus * taking immunosuppressants
study of the distractibility syndrome in patients with progressive supranuclear palsy

Conditions: Supranuclear Palsy, Progressive

Summary: the syndrome of distractibility is a behavioral disorder induced by a lesion or a dysfunction of the frontal lobe. this sign is frequent in patients with progressive supranuclear palsy (psp), a neurodegenerative disorder with severe neuronal loss in the prefrontal cortex and cholinergic systems, in particular in the meynert basalis nucleus. this could participate in the occurrence of the distractibility in these patients. the aim of this study is to evaluate the effect of the donepezil, an anticholinesterase, on the distractibility in psp patients, by using oculomotor and neuropsychological assessments.


Eligibility criteria:
inclusion criteria: * patients with psp * age \> 30 years old * disease duration \< 5 years * mini mental state (mms) \> 24 * antisaccades %: 40-80% exclusion criteria: * other parkinsonian syndromes * mms \< 24

Keywords: progressive supranuclear palsy frontal lobe oculomotor testing neuropsychological scores motor disability (updrs) distractibility