Kornimate/medical-research-clean huggingface dataset:
the efficiency of different exercise methods in adolescent idiopathic scoliosis

Conditions: Adolescent Idiopathic Scoliosis

Summary: the vertebral column is a structure that transfers the weight of the head and torso to the lower extremity, provides trunk movements and protects the spinal cord.a three dimensional deformity involving lateral flexion of the vertebrae in the frontal plane at 10 ° and above, including axial rotation and physiologic flexion (hypokyphosis) components in the sagittal plane, is defined as scoliosis. adolescent idiopathic scoliosis (ais) is a type of idiopathic scoliosis that occurs in the period from the onset of puberty (up to 10 years) until the closure of growth plates. scoliosis is caused by postural, balance and neuromotor disorders as a primary cause of impaired sensory integrity, proprioceptive feedback deficits, secondary lung problems, organ disorders and pain. in addition, the quality of life in these individuals is also seen to decrease. there are no studies in the literature examining the effects of schroth exercise training on trunk muscle strength, respiratory muscle strength, trunk muscle stiffness, balance and quality of life in children with adolescent idiopathic scoliosis. the aim of our study is to examine whether schroth exercise training has an effect on trunk muscle strength, trunk muscle stiffness, respiratory muscle strength, balance, quality of life and perception of cosmetic deformity in children with adolescent idiopathic scoliosis. it is thought that this study will fill the gap in the literature with the original information it will bring to the literature and will shed light on future studies.


Eligibility criteria:
inclusion criteria: * patients with ais scoliosis * individuals agreeing to participate in the study * patients between the ages of 10-20 * patients with ais whose cobb angle measured on x-ray is between 15-40 degrees exclusion criteria: * documented diagnosis any of cardiopulmonary, neurological, orthopedic or mental disorders which may affect the assessments results. * patients previously undertaken any of spinal surgeries. * patients involved in exercise training 3 or more days a week

Keywords: adolescent idiopathic scoliosis schroth exercises scoliosis specific exercises trunk muscle strength respiratory muscle strength muscle stiffness
safety and efficacy of milnacipran in pediatric patients with primary fibromyalgia

Conditions: Primary Fibromyalgia

Summary: the purpose of this study is to evaluate the safety, tolerability, efficacy, and pharmacokinetics of milnacipran in pediatric patients aged 13 to 17 years with primary fibromyalgia.

* 8 weeks open-label treatment period with milnacipran. * followed by randomization to 8-weeks double blind treatment period for eligible patients

Eligibility criteria:
inclusion criteria: * diagnosis of primary fibromyalgia * 13-17 years of age * to be eligible for screening, have average pain rating in the previous week of at least 3 but no more than 9 on an 11-point numeric rating scale * to be eligible to enter into the open-label treatment period, have a 1-week mean of daily pain ratings of at least 3 but no more than 9 (11-point numeric rating scale) in the week before baseline (visit 2) * to be eligible for randomization and entry into the double-blind treatment period, have a decrease of at least 50% in 1-week mean of daily pain ratings (11-point numeric rating scale) before randomization (visit 7) compared with the 1-week mean of daily pain ratings, in the week before baseline (visit 2) * unsatisfactory response to nonpharmacologic fibromyalgia treatment. exclusion criteria: * severe psychiatric illness * severe renal impairment * evidence of active liver disease * pregnant or breastfeeding * significant risk of suicidality * unable, unwilling or inadvisable to discontinue prohibited medications * history of alcohol abuse or drug abuse or dependence, within previous year * current systemic infection * autoimmune disease * history of seizure disorder (other than febrile seizures)

Keywords: fibromyalgia pediatric fibromyalgia adolescent fibromyalgia milnacipran savella loss of therapeutic response forest research institute pain fatigue serotonin norepinephrine reuptake inhibitors randomized withdrawal
covid-19 induced telogen effluvium

Conditions: Covid19; Telogen Effluvium; SARS-CoV Infection; Alopecia

Summary: this study inquires about the development of telogen effluvium following the sars-cov-2 infection

telogen effluvium (te) is one of the most common causes of non-scarring alopecia. during the covi̇d-19 pandemic, there is an increased number of telogen effluvium patients.this study inquires about the development of telogen effluvium following the sars-cov-2 infection and correlation between the severity of covid-19 and te.

Eligibility criteria:
inclusion criteria: * sars-cov-2 infection in the past year exclusion criteria: * other common causes of telogen effluvium ( such as anemia, iron deficiency, thyroid dysfunction)

Keywords: telogen effluvium covid-19 alopecia
retrospective tms therapy for adults with mdd

Conditions: Major Depressive Disorder (MDD)

Summary: examine change in the magnitude of antidepressant effects as a function of number of tms sessions and to determine whether extended treatment courses, beyond 30 and beyond 36 tms sessions, result in improved efficacy.

the efficacy of tms in major depressive disorder (mdd) has markedly improved since the pivotal sham-controlled trials. while this enhanced efficacy has been attributed to use of longer treatment courses, the impact of number of treatment sessions on efficacy has not been adequately evaluated. the study device is the neuronetics, inc. neurostar® tms therapy system (k160703, k201158).the study is a retrospective analysis of real-world data from commercial centers. the data will be gathered from the neuronetics database called trakstar which collects records of each patient's treatment. the data will be used only as applicable to the objectives of this study.

Eligibility criteria:
inclusion criteria: 1. male or female. 2. at least 18 years of age. 3. treatment with neurostar tms therapy. 4. treatment date of november 01, 2008 or later. 5. patient received at least one treatment with neurostar tms therapy according to standardized neurostar tms therapy treatment protocols. 6. primary diagnosis of major depressive disorder (mdd) with no comorbid diagnosis. 7. phq-9 scores available at baseline (pre-treatment). 8. moderate or greater depression prior to the initial treatment course with neurostar tms therapy, defined as baseline score on the physician health questionnaire-9 (phq- 9) ≥ 10.
anal fistulae internal opening closure by otsc clip after video assisted tract fulguration

Conditions: Anal Fistula

Summary: this study is expected to recruit 20-25 cases treated with video assisted anal fistula treatment. additionally the internal opening of the fistulae will be closed by an otsc clip.

sphincter damage after anal fistulae surgery is the most important cause of incontinence in adults. surgeons are gradually gradually getting more reluctant for creating any damage to sphincter for this reason. anteriorly located, high and trans-sphincteric fistulae are at more risk. ablating the fistula tract by laser or diathermy has been in use for a long time. recently a rigid thin camera to visualize all side tracts and branches for ablating them under direct vision has also been in use especially in europe. recently, closing the internal opening after ablating the fistula tract was reported to offer higher success rates for healing with less recurrence. the success rate was higher when the opening was closed by a stapler device. our aim in this study is to use o novel technique by using otsc clip for water tight closure of the internal fistula opening after diathermy ablation of the tract under direct vision and compare the healing and recurrence rates with other methods.

Eligibility criteria:
inclusion criteria: patients with trans-sphincteric and inter-sphincteric perianal fistulae - exclusion criteria: * presence of acute abscess, inflammatory bowel disease, myeloproliferative disease, established incontinence, recto-vaginal fistula

Keywords: vaaft otsc diathermy ablation of fistula tract
intrapleural instillation of the nivolumab in cancer patients with pleural effusion.

Conditions: Renal Cell Cancer Metastatic; Non-small Cell Lung Cancer Metastatic; Pleural Effusion, Malignant

Summary: patients with advanced cancers who have pleural effusion, especially those requiring pleural evacuation, experienced poorer survival when treated with immunotherapy. the pleura also acts as a natural barrier that can limit the penetration of immune checkpoint inhibitors. in this multicenter phase 2 study, the preliminary efficacy and toxicity of intrapleural instillation of the nivolumab in patients with immune-sensitive metastatic cancers will be accessed.

patients ≥18 years old who have large volume of pleural effusion, required evacuation, and received systemic therapy with a checkpoint inhibitor (monotherapy or combination with another checkpoint inhibitor) for metastatic cancers (renal cell carcinoma (rcc) and non-small cell lung cancer (nsclc) will be eligible. drainage followed by nivolumab (40 mg, single intrapleural instillation) will be performed.

Eligibility criteria:
inclusion criteria: * patients ≥18 years old * large volume of pleural effusion (1 liter and more), required evacuation * systemic therapy with a checkpoint inhibitor (monotherapy or combination with another checkpoint inhibitor) * metastatic cancers (renal cell carcinoma (rcc) and non-small cell lung cancer (nsclc) exclusion criteria: * autoimmune disorders * previous treatment for

Keywords: nivolumab intrapleural irrigation pleural carcinomatosis
influence of trabeculectomy and phaco-trabeculectomy on corneal astigmatism

Conditions: Astigmatism; Glaucoma

Summary: this study investigates the effects of trabeculectomy and combined phacoemulsification plus trabeculectomy on corneal astigmatism.

prospectively, consecutive patients at the university hospital of zurich undergoing either trabeculectomy (trab) or phaco-trabeculectomy (phaco-trab) are included in this study between january and december 2017. the study interventions takes place 6 months after surgery and include examination of refraction, biometry and corneal topography in order to assess the patient's astigmatism. the values are compared to the preoperative baseline values, which are available from patient records.

Eligibility criteria:
inclusion criteria: * trabeculectomy or phaco-trabeculectomy between 01/2017 and 12/2017 * age ≥18 years exclusion criteria: * acute or chronic corneal diseases
3d printing guides in total knee arthroplasty

Conditions: Osteoarthritis of the Knee

Summary: this study aims to design a patient-specific instrumentation to be used in total knee arthroplasty and evaluate its accuracy of femoral component rotation and intramedullary guide so as to explore its clinical effects.

total knee arthroplasty (tka) is the most universal and effective means for treating terminal stage osteoarthritis (oa) of knee. with the development of three-dimensional printing (3dp) technology in the medical domain, the application of patient-specific instrumentation (psi) in arthroplasty has become more common. the aim of this study was to design a psi to achieve appropriate femoral resection and accurate component rotation for a successful tka, and to explore its clinical effects.

Eligibility criteria:
inclusion criteria: * patients with advanced oa of the knee, varus deformity of no more than 15 degrees, flexion-contracture deformity of no more than 10 degrees, without extra-articular deformity of the knee; * weight-bearing radiograph of the x-ray image showed the oa kellgren-lawrence classification grade ⅳ; * the treatment for the patient was tka, whether or not to use psi depends on the actual grouping. exclusion criteria: * patients with varus deformity of more than 15 degrees, flexion-contracture deformity of more than 10 degrees of the knee; * patients with traumatic arthritis and inflammatory arthritis; * patients with huge bone defects around the knee * patients who had active infection around the knee; * patients with knee valgus deformity; * patients with severe extra-articular deformity; * patients who had previous knee surgery; * patients who had periarticular soft tissue dysfunction and neuropathy; * patients who had poor physical condition and could not withstand the operation; * patients who refused to be followed.
study of the associations between subchondral insufficiency fractures of the knee and pre-existing health, lifestyle, and/or musculoskeletal conditions

Conditions: Subchondral Insufficiency Fracture

Summary: this prospective cohort study is designed to investigate possible association(s) between subchondral insufficiency fractures (sifks) of the knee and pre-existing health, lifestyle, and/or musculoskeletal conditions. in doing so, this research may shed light on the underlying cause(s) of sifks. it is hypothesized that sifks of the knee are related to osteoarthritis, weak bone, and/or metabolic issues, rather than trauma.


Eligibility criteria:
inclusion criteria: * patients diagnosed with sifk from ages ≥18 years old who seek treatment at the university of massachusetts for their musculoskeletal care. exclusion criteria: * patients with a history of associated conditions such as cancer, inflammatory arthritis, or chronic alcohol or tobacco dependence will be excluded. the following special populations will be excluded: * adults unable to consent and/or unable to follow two-step commands * individuals who are not yet adults (infants, children, teenagers) * pregnant women * prisoners * non-english-speaking patients

Keywords: exercise musculoskeletal diseases nutrition disorders pain
computed tomography perfusion colorectal cancer with tumor grade

Conditions: Colo-rectal Cancer

Summary: colorectal cancer is the third most commonly diagnosed cancer in the world. the 5-years survival rate depends on the tumor stage and grade at patient presentation. individual treatment strategy based on the tumor stage and grade should be applied to improve the prognosis, so the pre-operative diagnostic evaluation and grading of colorectal cancer are important.

diagnosis of cancer colon is usually based on colonoscopy which provides direct visualization of the lesions and allows for biopsies. however the pre-operative specimens from endoscopic biopsies sometimes fail to grade tumor because of the lack of sufficient tissue. recent improvements in computed tomography have allowed for minimally invasive evaluation of cancer colon. quantitative iodine density measurement can be used to differentiate low and high grade colorectal cancer. however, debate continues regarding the correlation between tumor grade and computed tomography perfusion parameters of colorectal cancer demonstrating the need for further investigation in this area of research.

Eligibility criteria:
inclusion criteria: * any patient with primary colorectal mass exclusion criteria: * colorectal mass pathologically proved to be benign female patient at child bearing period with suspected pregnancy raised renal chemistry hypersensitivity to contrast.
sarcopenia is an independent prognostic factor for overall survival in patients with pancreatic adenocarcinoma

Conditions: Pancreatic Neoplasms

Summary: the primary objective of this study was to validate total psoas area (tpa) measurement as an independent prognostic factor of overall survival in patients with pancreatic adenocarcinoma. secondary objective was to describe the evolution of the tpa during the follow-up.


Eligibility criteria:
inclusion criteria: * all patients consecutive enrolled from january 2009 to december 2015 who underwent at least one chemotherapy for pancreatic adenocarcinoma, whatever the stage exclusion criteria: * a patient record captured outside the time frame from january 2009 to december 2015
investigation of the effect of age and injury severity on short-term intra-hospital outcomes after surgical stabilized rib fractures

Conditions: Rib Fractures; Rib Trauma; Rib Fracture Multiple; Thorax; Fracture

Summary: the study aims to investigate the effect of surgical stabilisation of rib fractures (ssrf) on clinical outcomes measured during the hospital stay (mortality, days on a mechanical ventilator, intensive care unit and hospital length of stay, rate of complications). furthermore, the effect of the patients age and overall injury severity on the outcomes after ssrf will be investigated. we hypothesise that the combination of high age and high injury severity will lead to worse outcomes after ssrf.


Eligibility criteria:
inclusion criteria: * patients of the university hospital muenster * coded serial rib fractures (icd s22.4 and s22.5) * treatment for the rib fractures between 2019 and 2023 exclusion criteria: * pathological rib fractures (due to suspected malignancy)

Keywords: surgical stabilisation of rib fractures (ssrf)
physiological-based cord clamping in congenital diaphragmatic hernia

Conditions: Hernias, Diaphragmatic, Congenital; Hernia; Diaphragm Defect, Congenital; Pulmonary Hypertension

Summary: pulmonary hypertension is a major determinant of postnatal survival in infants with a congenital diaphragmatic hernia (cdh). the current care during the perinatal stabilisation period in infants born with this rare birth defect might contribute to the development of pulmonary hypertension after birth - in particular umbilical cord clamping before lung aeration. an ovine model of diaphragmatic hernia demonstrated that cord clamping after lung aeration, called physiological-based cord clamping (pbcc), avoided the initial high pressures in the lung vasculature while maintaining adequate blood flow, thereby avoiding vascular remodelling and aggravation of pulmonary hypertension. the investigators aim to investigate if the implementation of pbcc in the perinatal stabilisation period of infants born with a cdh could reduce the incidence of pulmonary hypertension in the first 24 hours after birth. the investigators will perform a multicentre, randomised controlled trial in infants with an isolated cdh. before birth, infants will be randomised to either pbcc or immediate cord clamping, stratified by treatment centre and severity of pulmonary hypoplasia on antenatal ultrasound. for performing pbcc a purpose-designed resuscitation module (the concord birth trolley) will be used.


Eligibility criteria:
inclusion criteria: * left-sided cdh * isolated cdh: no associated structural or genetic abnormalities that are diagnosed before birth * gestational age at delivery ≥35.0 weeks * parental written informed consent exclusion criteria: * right-sided or bilateral cdh * gestational age at delivery \<35.0 weeks * maternal contraindications: anterior placenta praevia, placental abruption * high urgency caesarean section, with intended interval to delivery \<15 min * cases that have been treated during pregnancy with experimental drug therapy aiming to decrease the occurrence of pulmonary hypertension * twin pregnancies in which the infant diagnosed with a cdh is born first * multiple birth \>2 (triplets or higher order)

Keywords: congenital diaphragmatic hernia perinatal stabilisation resuscitation pulmonary hypertension birth defect physiological-based cord clamping
avoidant and restrictive food intake disorders (arfid) in adolescence: early oral development, psychopathological profile and sensory integration

Conditions: Avoidant and Restrictive Food Intake Disorders

Summary: the purpose of this study is to assess if adolescents affected with avoidant and restrictive food intake disorders (arfid) had more frequent precocious pediatric feeding disorders before 4 years old compared to healthy adolescents.

this research focuses on retrospective analysis of early pediatric feeding disorders seen for arfid in adolescence in two departments of the dmu mefado. this assessment will be implemented during a hospital visit by a questionnaire completed by the patient's parents covering the first years of the child's life in medical, behavioural and dietary terms. this questionnaire was created for this study and, therefore, is not validated for general population. the parents will also complete the montreal children feeding scale based on their memories. the montreal children feeding scale is a validated parental self-questionnaire, allowing the screening of feeding and eating disorders in children under 6 years old. since the study specific questionnaire is not validated, 60 non-arfid controls will be included in the study for questionnaires completion. the research also focuses on the psychopathological profile of these adolescents with arfid regarding their degree of anxiety, their degree of depression, their possible autistic traits and their sensory sensitivity. these aspects will be studied by validated self- and hetero-questionnaires standardized for these fields. the emotional expression of the parents will be assessed during a brief qualitative interview type "five-minute speech sample".

Eligibility criteria:
inclusion criteria: for all patients: * adolescent aged 12 to 18 (minors = 17 years 11 months) * no opposition from parents and adolescent for arfid patients: * consulting at mda or necker for an arfid diagnosed using dsm v criteria * whose first consultation for this disorder was less than 2 years ago for non-arfid patients: * consulting or hospitalized in orthopaedic surgery at necker hospital or robert debré hospital for an acute traumatic reason * not diagnosed with a chronic illness exclusion criteria: for all patients: - parents and adolescents who do not speak french well enough to understand the questions on the scales and questionnaires for arfid patients: - diagnosis of autism spectrum disorder already made at the time of the consultation for non-arfid patients: - presence of a chronic organic or psychological illness, to limit the risk of including non arfid patients at high risk of eating disorders

Keywords: avoidant and restrictive food intake disorders arfid eating disorder adolescent depression autism anxiety sensory sensitivity