Kornimate/medical-research-clean huggingface dataset:
kinetics of microparticles under chemotherapy in patients with gastric or pancreatic cancer

Conditions: Pancreatic Cancer; Gastric Cancer

Summary: microparticles have recently emerged as a thrombotic risk marker with a potential role in determining which patients are at greatest risk for developing thrombosis. available data show an increase in the level of microparticles in cancer patients who are undergoing chemotherapy for solid tumors with a possible link to their thrombogenic state. our study focuses on the kinetics of microparticles under chemotherapy in patients with pancreatic or gastric cancer by serial measurements of microparticles procoagulant activity. detailed description: the impact of chemotherapy on microparticles expression will be assessed by measuring their procoagulant activity on blood samples taken during the course of chemotherapy. the thrombotic risk will be evaluated by the score of khorana in parallel. microparticles expression in patients with thrombosis will be compared to that in other patients.


Eligibility criteria:
inclusion criteria: * first-line chemotherapy indicated and accepted by the patient for pancreatic cancer or gastric cancer * confirmed diagnosis of pancreatic cancer or gastric cancer * free subject, without guardianship or trusteeship or subordination * patient benefiting from a social security scheme or benefiting through a third party * consent given by the patient after clear and fair information about the study exclusion criteria: * age \< 18yo * life expectancy ≤10days * deep vein thrombosis ou pulmonary embolism ≤3months * patient unable to receive chemotherapy (sepsis, acute coronary syndrome, recent stroke, heparin-induced thrombocytopenia, disseminated intravascular coagulation) * person enjoying enhanced protection, namely minors, persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social institution, adults under legal protection, and finally patients in emergency situations * pregnant or lactating woman and woman of childbearing age lacking effective contraception

Keywords: microparticles pancreatic cancer gastric cancer chemotherapy venous thromboembolism
a trial of multi-convergent therapy for functional symptoms and stress in patients with inflammatory bowel disease

Conditions: Inflammatory Bowel Disease

Summary: the purpose of this study is to determine whether multi-convergent therapy is helpful to patients with inflammatory bowel disease who have functional abdominal symptoms or high perceived levels of psychological stress.


Eligibility criteria:
inclusion criteria: * diagnosis of inflammatory bowel disease * clinical remission of inflammatory bowel disease as defined by an adapted disease activity index and a crp \<10 * age 18 to 65 years * evidence of irritable bowel syndrome (rome iii criteria) or high perceived stress level (levenstein perceived stress score \> 0.44) exclusion criteria: * use of steroids within 1 month of entry to study * initiation or change in dose of medication within 1 month of entry to the study * presence of ileostomy or colostomy * diagnosis of dementia or cognitive impairment * current psychosis or substance misuse * change in psychotropic medication in 3 months prior to entry to study * previous psychological interventions * pregnancy

Keywords: multi-convergent therapy mindfulness meditation functional abdominal symptoms irritable bowel syndrome inflammatory bowel disease psychological stress
diagnostic accuracy of ultrasonography and computed tomography in the diagnosis of mild-moderate acute diverticulitis

Conditions: Acute Diverticulitis

Summary: acute diverticulitis (ad) is the most common complication of diverticulosis and is divided into mild-moderate and complicated. imaging methods are needed for its diagnosis, prognostic classification and therapeutic management. currently the "gold-standard" imaging technique is computed tomography (ct) and most guidelines recommend it to classify and identify those patients with risk of treatment failure. in this styudy, a prospective comparison of ct and abdominal ultrasound is proposed, with the aim of evaluating the diagnostic accuracy of ultrasound. an accurate ultrasound classification of ad would allow the differentiation of mild-moderate and complicated da, avoiding routine ct and, therefore, patient's x-ray exposure.

study design, setting and patients. pragmatic prospective cohort study comparing the diagnostic accuracy of us and ct scan. during a 17-month period patients referred to the imaging department with a clinical suspicion of acute lcd will be evaluated with us and ct. following the hospital care protocol, patients with suspected uncomplicated lcd will first undergo an abdominal us examination. immediately after us examination, patients will be evaluated with ct. in emergency cases in which complicated diverticulitis is suspected, the study will start with a ct, followed by ultrasound. the interval between both exploration test will be in all cases less than 1 hour and will be performed before the administration of any anti-inflammatory or antibiotic treatment. us and ct exams will be performed by three different radiologists with blinded results between them. all participating radiologists have more than five years of experience in abdominal radiology. us examinations will be performed with a scanner aplio 500 (canon, tokyo, japan) employing convex and lineal transducer. ct studies will be performed on 6-mdct scanner (somatom emotion siemens, germany) following the administration of 120ml of intravenous contrast.

Eligibility criteria:
inclusion criteria: * clinical suspicion of acute diverticulitis exclusion criteria: * hemodynamic instability that prevents a diagnostic delay * pregnant patients * previous history of allergy to iodinated contrast

Keywords: ultrasonography computed tomography accuracy sensitivity and specifity
active screening of arterial hypertension by community outreach workers in the cayenne metropolitan area to reduce the incidence of cardiovascular disease

Conditions: High Blood Pressure

Summary: the main objective is to implement of a community-based primary care intervention against high blood pressure. we want to show that this intervention decreases the incidence of stroke in the community of agglomerations of the central coast of french guiana, with a rapid effectiveness of about -30% at 2 years.

the hypothesis of the research is that, thanks to a strategy of early detection of hypertension based on "outreach" by community relays, it will be possible to increase the effectiveness of primary prevention among the precarious population (early treatment, access to healthcare, improvement of therapeutic follow-up, reduction of renunciations and interruptions of treatment). this strategy, adapted to the guianese context, would make it possible to reduce the incidence and mortality of cardiovascular diseases among the most vulnerable people, particularly stroke. such data would be a prerequisite for a more ambitious strategy, aiming to implement policies on a sufficient scale policies on a scale and intensity sufficient to have an impact on the problem of social inequalities in health other than those related to high blood pressure. the quasi-experimental before-and-after methodology makes it possible to compare, on a population basis, a quantitative endpoint - in this case the number of strokes - between before and after the implementation of a public health intervention. for reasons of acceptance by the partners, statistical power, and potential bias, a before-and-after design seems more interesting. it will be a pre-screening of hypertension, a possible referral for medical care or opening of health care rights and health education through hygienic and dietary advice and health prevention focused on hypertension.

Eligibility criteria:
inclusion criteria: * adults of at least 18 years old * residents of the agglomeration community of the central coast of french guiana. exclusion criteria: * person who has objected to participating in the study * person under guardianship or curatorship, persons under protective supervision

Keywords: high blood pressure precarity community outreach workers cardiovascular disease health care
evaluation of the safety and performance of centaflow

Conditions: Fetal Growth Restriction

Summary: the aim of this study is to evaluate the safety and performance of an acoustic approach based on skin-contact microphones as a routine assessment of placental vascular function as predictor of fetal growth restriction.

evaluation of the safety and performance of centaflow as routine antenatal assessment of placental vascular function as predictor of fetal growth restriction is performed by randomizing singleton pregnant women with ultrasound-based gestations for either standard care (sc) or sc and centaflow (cf). the subjects will be randomized in ratio 1:1 in both groups and examined in pregnancy weeks 27-29, 34-36 and 37-39.

Eligibility criteria:
inclusion criteria * female subjects over the age of 18 years. * subejct is pregnant, carries only one fetus and has been pregnancy dated by ultrasound scan (hadlock reference). exclusion criteria * fetal abnormality known to affect growth, diagnosed in-utero or through 12 days postnatally.
atacicept in subjects with optic neuritis

Conditions: Optic Neuritis

Summary: this study was intended to evaluate the efficacy, safety and tolerability of atacicept compared to placebo and to explore the neuroprotective effect of atacicept as assessed by oct in subjects with on as cis. the study was randomized. study medication was administered via subcutaneous (under the skin) injections.


Eligibility criteria:
inclusion criteria: * diagnosis of unilateral symptomatic optic neuritis as first clinical manifestation within 28 days between onset of symptoms and study day 1 * other protocol defined inclusion criteria could apply exclusion criteria: * pre treatment with immunosuppressants and immunomodulating drugs * relevant cardiac, hepatic and renal diseases * clinical significant abnormalities in blood cell counts and immunoglobulin levels * clinical significant acute or chronic infections * other protocol defined exclusion criteria could apply

Keywords: atacicept neuritis
the effect of a liquid protein modular on growth and outcomes in the nicu

Conditions: Problem With Growth of an Infant

Summary: the investigators hypothesis that premature infants receiving a commercially available liquid protein modular will have improved growth when compared with premature infants receiving a commercially available powder protein modular.


Eligibility criteria:
inclusion criteria: * infants less than 2000 gms at birth, receiving maternal breast milk exclusion criteria: * infants receiving formula

Keywords: premature infant feeding protein
spo2 accuracy validation of pulse oximetry systems during motion and non-motion conditions

Conditions: Hypoxia

Summary: study to evaluate the %spo2 accuracy performance of the nonin medical pulse oximetry systems.

study to evaluate the %spo2 accuracy performance of the nonin medical pulse oximetry systems during motion and non-motion.

Eligibility criteria:
inclusion criteria: * the subject is male or female * the subject is of any racial or ethnic group * the subject is \> 30 kg (\>66 pounds) in weight (self-reported) * the subject has at least one finger height of 0.2 - 1.0 inch (based on measurement) * the subject is between 18 years and 45 years of age (self=reported) * the subject shows no evidence of medical problems as indicated by satisfactory completion of the health assessment form * the subject has given written informed consent to participate in the study * the subject is both willing and able to comply with study procedures. exclusion criteria: * the subject has a bmi greater than 31 (based on weight and height) * the subject has had any relevant injury at the sensor location site (self-reported) * the subject has deformities or abnormalities that may prevent proper application of the device under test (based on examination) * the subject is current smoker (self-reported) * the subject has a known respiratory condition (self-reported) * the subject has a known heart or cardiovascular condition (self-reported) * the subject is currently pregnant (self-reported) * the subject is actively trying to get pregnant (self-reported) * the subject has a clotting disorder (self-reported) * the subject has raynaud's disease (self-reported) * the subject is known to have a hemoglobinopathy (self-reported) * the subject is on blood thinners or medication with aspirin (self-reported) * the subject has unacceptable collateral circulation from the ulnar artery (based on examination) * the subject is unwilling or unable to provide written informed consent to participate in the study * the subject is unwilling or unable to comply with the study procedures * the subject has another health condition which in the opinion of the principal investigator makes him/her unsuitable for testing.
treatment of poor ovarian responders with corifollitropin alfa followed by hphmg in a short gnrh agonist protocol

Conditions: Infertility; Poor Ovarian Response

Summary: the purpose of the present study is to examine the level of ovarian response and the pregnancy rates among poor ovarian responders treated with a novel treatment protocol with 150μg corifollitropin alfa followed by 300iu hmg in a short gnrh agonist protocol.

corifollitropin alfa reaches maximum concentrations (cmax), between 25 and 45 h after injection , a time interval which is significantly shorter as compared to treatment with rfsh. the investigators hypothesized that this rapid increase in the serum fsh concentration may result in a significantly higher exposure of the small antral follicles to constant high levels of fsh during the early follicular phase, securing not only the recruitment of the follicles, but also the continued growth. in the current study the investigators examine whether administration of corifollitropin followed by 300iu hmg in a short gnrh agonist protocol may result in acceptable pregnancy rates in poor ovarian responders fulfilling the "bologna criteria"

Eligibility criteria:
inclusion criteria: patients should fulfill the "bologna criteria" for poor ovarian response at least two of the following three features must be present: i. advanced maternal age (≥40 years) or any other risk factor for por (poor ovarian response); ii. a previous por (≤3 oocytes with a conventional stimulation protocol); iii. an abnormal ovarian reserve test (i.e. afc \<7 follicles or amh \<1.1 ng/ml). two episodes of por after maximal stimulation are sufficient to define a patient as poor responder in the absence of advanced maternal age or abnormal ort (ovarian reserve test). exclusion criteria: -

Keywords: poor ovarian response poor ovarian responders bologna criteria for poor ovarian response
intracranial hydatid cyst

Conditions: Intracranial Neoplasm

Summary: central nervous system (cns) hydatid cysts is a rare presentation of hydatid cyst, although may be the cause of intracranial space-occupying lesions in 4% in endemic countries. it affects mostly children. the diagnosis of cns hydatid is still problematic in spite of the advancements in imaging techniques (ct or mri). extirpation of the intact cyst is the treatment of choice, resulting in most cases to a complete recovery.

hydatid disease is a parasitic induced disease caused by either echinococcus granulosus or echinococcus multilocularis during the larval stage of these tapeworms. hydatid cysts are endemic in many countries, such as latin america (argentina, brazil, chile, peru, and uruguay); followed by europe (france, italy, and greece), the middle east (turkey, lebanon, syria, and jordan), southeast asia (china, iran, and india) and africa (tunisia and less commonly, egypt)

Eligibility criteria:
inclusion criteria: * intracranial hydatid cyst exclusion criteria: * arachnoid cysts * conservative treatment
using virtual reality (vr) models for robotic prostatectomy

Conditions: Prostate Cancer

Summary: a prospective, randomized, controlled study designed to assess whether digital virtual reality (vr) models, created from existing ct scans and mris, provide surgeons with an improved understanding of their patients' anatomy, resulting in more efficient operations (robotic prostatectomy) and improved patient care.


Eligibility criteria:
inclusion criteria: * patient is undergoing robotic prostatectomy being performed by participating surgeon * patient is willing to be randomized between intervention and control arms exclusion criteria: * patients with prior pelvic radiation * patients with prior androgen deprivation therapy * patients with prior localized ablative therapy * patients with prior turp or other surgical bph treatment
effects of tai chi chuan on psychobiological indicators of anxiety and sleep quality in young adults

Conditions: Anxiety

Summary: the purpose of this study is to determine the feasibility of a 10-week tai chi chuan intervention as a treatment for anxiety and sleep quality in young adults.


Eligibility criteria:
inclusion criteria: * mild to severe symptoms of anxiety * interest in participating in an exercise intervention * willingness to accept randomization * provides informed consent * low or moderate risk for acute cardiovascular event exclusion criteria: * currently receiving psychotherapy or medication for psychological problems * current suicide or homicide risk * current or history of psychosis * current alcohol or substance dependence * high risk for an acute cardiovascular event * current use of prescription drugs with potential to influence the parasympathetic or sympathetic nervous system * current or previous extensive involvement in mind-body exercise * symptoms of severe depression

Keywords: anxiety sleep quality tai chi chuan young adults
pilot study of a geriatric intervention after colorectal and lung cancer surgery

Conditions: Colorectal Cancer

Summary: surgery for colorectal cancer is a major surgery. people above the age of 60 tend to have a higher risk of complications. some studies indicate that senior cancer patients might benefit from a home support after surgery by a geriatric nurse practitioner and a team, beside their usual post-operative care. the investigators team is planning a large study to assess whether this approach could help patients with colorectal cancer recover better from their surgery, get better cancer treatment after that (e.g. chemotherapy), and possibly live longer. this study you are asked to take part in is a pilot for this large study.

our key background data come from the randomized study conducted by mccorkle et al. after evaluation testing, patients will be randomly assigned (similarly to a coin toss) to one of two possible follow-up groups. one would be a regular post-surgery care group (control group), the other will have in addition a support by geriatric nurse practitioner (intervention group). patients who are assigned to the intervention group: once they arrive home, in addition to their normal post-surgery care, will receive a once a week home visit by a geriatric nurse practitioner (gnp). the gnp will also call the patient once a week in between. the gnp will check any problem patients may have during their recovery and provide or organize care for it. the gnp has a checklist of problems to address so that we can reliably reproduce our intervention in other patients. the gnp will work together with the patient's various doctors and caregivers, as well as a geriatric team. some of the visits or the telephone calls maybe tape-recorded so that the research team can evaluate the information provided to the patient. we will record any complication patients might have from surgery. no matter which treatment group the patient is assigned to, at the end of a 4 weeks period, we will repeat the tests we did at the beginning to see how they change.

Eligibility criteria:
inclusion criteria: * colorectal cancer, stage iii or iv, confirmed by histology * abdominal surgery by a university of south florida (usf) surgeon at moffitt cancer center or tampa general hospital (tgh) * age 60 years and older * informed consent * living within a one (1) hour radius of moffitt exclusion criteria: * discharge planned to a rehabilitation facility or a nursing home * unable to answer the questionnaires (e.g. because of cognitive impairment, blindness, deafness) * post-operative inpatient stay \>one (1) month

Keywords: colon geriatric mccorkle model questionnaire
the predictive performance of renal ultrasound on changes in renal clearance

Conditions: Acute Kidney Injury; Hypoperfusion; Fluid Overload

Summary: the study will examine the ability of renal ultrasound (doppler and contrast enhanced ultrasound (ceus)) in distinguishing icu patients who exhibit increases in glomerular filtration rate (gfr) in response to fluid loading, from those for whom fluid loading is without benefit of directly harmful.

the study will examine the ability of renal ultrasound (doppler and contrast enhanced ultrasound (ceus)) in distinguishing icu patients who exhibit increases in gfr in response to fluid loading, from those for whom fluid loading is without benefit of directly harmful. patients available for inclusion will receive a baseline administration of tc-99-dtpa for precise determination of gfr/renal function by blood and urine samples. baseline values of ultrasound measures will be obtained, including renal arterial, renal venous, portal venous and hepatic venous doppler measures and renal contrast enhanced ultrasound (ceus) will also be recorded. after two hours, baseline values of gfr are finished. the patient is then exposed to passive leg raising and ultrasound measures are repeated, including renal arterial, renal venous, portal venous and hepatic venous doppler measures. the participant then receives a standardised fluid bolus of 7 ml/kg (ideal body weight) once the fluid bolus administration is complete, renal ultrasound is repeated, including renal arterial, renal venous, portal venous, hepatic venous doppler measures and renal ceus. follow-up determination of gfr/renal function based on tc-99-dtpa after fluid therapy is repeated with blood and urine samples.

Eligibility criteria:
inclusion criteria: * patients ≥ 18 years admitted to the icu, aarhus university hospital. * patients who are assessed by their attending physician as having need for fluid therapy. exclusion criteria: * insufficient ultrasound imaging of the kidneys. * pregnancy. * intolerance to any ultrasound contrast agent or isotopes, including intolerance for human albumin. * prior enrolment in a conflicting research study. * known morphological kidney disease. * need for dialysis. * need for extracorporeal membrane oxygenation (ecmo). * prior participation. * severe pulmonary hypertension (systolic pulmonary pressure \> 90 mmhg)

Keywords: ultrasound renal perfusion fluid treatment venous congestion renal function