Kornimate/medical-research-clean huggingface dataset:
shock wave therapy on cervical pain following neck dissection surgery

Conditions: Pain; Cervical Pain

Summary: myofascial pain syndrome (mps) is a musculoskeletal disorder which is characterized by pain, muscle spasms and muscle tenderness, as well as a limited range of motion, weakness, and rarely, autonomous dysfunction.

the occurrences of morbidity of the neck after cancer therapy were considerable and consisted of neck pain, loss of sensation, and decreased range of motion. extracorporeal shock wave therapy (eswt) is one of the treatment options used for patients with myofascial pain syndrome through elimination of ischemia and modulation of vasoneuroactive substance (two major causes of trigger pathophysiology) and mechanical transduction as a cellular response to external stimulation. the aim of this study was to investigate efficacy of extracorporeal shock wave therapy (eswt) on cervical myofascial pain following neck dissection surgery.

Eligibility criteria:
inclusion criteria: 1. previous unilateral modified radical neck dissection. 2. patients with myofascial pain of upper trapezius for at least 3 months. 3. patients with palpable intramuscular taut band. 4. restriction in cervical rom of lateral flexion and rotation. 5. provocation of the clinical symptoms by compression of the active trigger point exclusion criteria: 1. patient who received medication or other therapies for mps within the previous 2 months. 2. patients with pacemaker, pregnancy 3. open wound at the treatment area. 4. cervical myelopathy or radiculopathy, cervical spine fracture or spondylolisthesis. 5. rheumatoid arthritis. 6. coagulopathy. 7. epilepsy or any psychological disorder.
isoflavones and peritoneal dialysis

Conditions: Peritoneal Dialysis

Summary: the aim of this double-blind randomized clinical trial is to determine the effects of isoflavones on serum concentrations of fructoseamine and advanced glycated end products in peritoneal dialysis patients. forty-four patients from shafa clinic will randomly assign to either isoflavone or placebo group. the patients in isoflavone group will receive 100 mg soy isoflavone (as 2 capsules) daily for 8 weeks, while the placebo group will receive identical placebo. at the baseline and the end of the study,7 ml blood will be collected from each patient after a 12-14-hours fasting and serum concentrations of fructoseamine, carboxymethyl lysine, pentosidine, glucose will be measured. furthermore, blood pressure measurements will be performed twice with a ten-minute interval between testing


Eligibility criteria:
inclusion criteria: continuous ambulatory peritoneal dialysis for 6 months or more body mass index below 35 exclusion criteria: infections inflammatory diseases liver diseases clinical diagnosis of cancer receiving glucocorticoid and anti-inflammatory drugs receiving isoflavone supplements constant consumption of soy or foods containing soy in the diet
the preemptive analgesic efficacy of nefopam

Conditions: Breast Neoplasm

Summary: nefopam is administered as a preemptive analgesic drug to the patient undergoing breast cancer surgery. it will be evaluated whether postoperative acute and chronic pain can be reduced.


Eligibility criteria:
inclusion criteria: * patients diagnosed with breast cancer * lumpectomy with axillary lymph node dissection or lumpectomy with sentinel lymph node biopsy * american society of anesthesiologists physical status i or ii exclusion criteria: * refusal * seizure * cardiac disease * monoamine oxidase inhibitor user * urologic disease * glucoma * preoperative analgesic drug medication * pregnancy * recurred breast cancer patient
single cell sequencing of tonsillar tissue in children with osa

Conditions: Obstructive Sleep Apnea of Child

Summary: obstructive sleep apnoea (osa) in children is a prevalent sleep disorder, and is characterised by repetitive complete or partial upper airway obstruction during sleep. it is an important disease as it is associated with a large spectrum of end-organ morbidities. adenotonsillar hypertrophy is the commonest cause of osa in children, however, the cause of the lymphoid tissue hypertrophy in some individuals but not the others remains unknown. to address the cellular heterogeneity and immune cell involvement in adenotonsillar hypertrophy, here, we propose to employ single-cell sequencing analysis to identify the cell-specific expression patterns associated with the disease, which will enhance our understanding of the pathogenesis of tonsillar hypertrophy in children with osa and may provide directions for development of novel therapy.


Eligibility criteria:
inclusion criteria: case: chinese children aged 6-11 years old with habitual snoring (≥3 nights per week) and polysomnography (psg) confirmed osa (obstructive apnoea hypopnoea index (oahi) of ≥1/hour), with adenotonsillar hypertrophy and clinical indications for adenotonsillectomy will be recruited as cases. control: non-osa subjects (with psg oahi \<1/hour) who undergo adenotonsillectomy for other reasons such as recurrent tonsillitis. exclusion criteria: previous upper airway surgery, genetic or syndromal disease, congenital or acquired neuromuscular disease, congenital or acquired immunodeficiency, known metabolic syndrome, craniofacial abnormalities.
comparison of hypoglycaemic response between nn1250 and insulin glargine in type 1 diabetics

Conditions: Diabetes; Diabetes Mellitus, Type 1

Summary: this trial iss conducted in europe. the aim of this clinical trial is to evaluate the hypoglycaemic response (the response to low blood sugar) to nn1250 (insulin degludec) in subjects with type 1 diabetes. the trial is designed as a two-period, crossover trial where the trial participant is randomised to one of two treatment periods.


Eligibility criteria:
inclusion criteria: * type 1 diabetes mellitus (as diagnosed clinically) for at least 12 months * body mass index 18.0-28.0 kg/m\^2 (both inclusive) exclusion criteria: * use of insulin glargine within 3 months prior to first dosing of investigational product in this trial * subject who has donated any blood or plasma in the past month or more than 500 ml within 3 months prior to screening * smoker * recurrent severe hypoglycaemia (more than 1 severe hypoglycaemic event during the last 12 months)
effectiveness of internet-based injury prevention program in enhancing mother's knowledge on child safety

Conditions: Child Safety; Injury Prevention; Internet-based Intervention; Anticipatory Guidance; Chinese Mothers

Summary: background: provision of anticipatory guidance to parents is recommended as an effective strategy to prevent injuries among young children. internet-based anticipatory guidance is suggested to reinforce the effectiveness of injury prevention, and improve parents' knowledge on child safety. parents receiving the guidance can reduce children's exposure to injury risk by adopting better childcare practices and using appropriate child safety devices at home. objective: this study will examine the effectiveness of internet-based injury prevention program with parental anticipatory guidance in enhancing mothers' knowledge on child safety. it aims at increasing mothers' knowledge and motivation of learning about domestic injury prevention through a new internet-based intervention model. it also targets to improve mothers' attitude and perceived behavioral control of domestic safety practice. methods: the study would adopt a randomized controlled trial design and recruit 934 mothers from the antenatal clinics and postnatal wards of two major public hospitals in hong kong. participating mothers will be randomized into the intervention or control group with equal likelihood. mothers in intervention group will be provided with free access to an internet-based injury prevention program with anticipatory guideline whereas those in the control group will receive relevant parenting booklet. results: it is hypothesized that mothers' general and age-appropriate knowledge on child safety and motivation of learning about domestic injury prevention as the primary outcome measures will be enhanced. conclusions: the internet is increasingly recognized as a practical and cost-effective platform for health education and safety information delivery. the goals of this study are to examine the effectiveness of a new internet-based intervention program for improving mothers' knowledge, and raising mothers' awareness about the importance and consequences caused by domestic injuries.


Eligibility criteria:
inclusion criteria: * mothers attending the antenatal clinics/staying in the postnatal wards at kwong wah hospital or queen mary hospital. exclusion criteria: * mothers unable to read chinese and those without access to internet.
effect of neurodynamic mobilization techniques in patients with diabetic neuropathy

Conditions: Diabetic Neuropathies

Summary: neurodynamic mobilization techniques and selected physical program used as a treatment for diabetic neuropathy patients and assessed by nerve condition study and function outcome.

neurodynamic mobilization techniques and selected physical program used as a treatment for diabetic neuropathy patients and assessed by nerve condition study and function outcome.

Eligibility criteria:
inclusion criteria: * diagnosed with t2dm for ≥10 years determined by electrophysiological measurements were enrolled. * the participants regularly took their diabetes medications during the assessment and treatment period. exclusion criteria: * uncontrolled t2dm and diagnosed with t2dm for \< 10 years. * patients with neural, muscular, and skeletal system deformities; radiculopathy; and psychiatric disorders.

Keywords: neurodynamic technique; sensory nerve conduction study; motor nerve conduction study; functional outcome; diabetic polyneuropathy.
implantation of olfactory ensheathing cells (oecs)

Conditions: Infarction, Middle Cerebral Artery; Ischemic Stroke,; Stroke With Hemiparesis,; Thromboembolic Stroke.

Summary: recruited patients should receive the endoscopic surgery for picking the olfactory mucosa 1 to 2 months before transplantation. the olfactory ensheathing cells (oecs) will be cultured and expanded under the rule of gtp. then, quality control of oecs should be done by immunohistochemical staining positive for gfap, s100, and p75. finally, the investigators will transplant the oecs (about 2 to 8 x 10´6 cells in saline) into the peri-infarcted area of the brain.

(1)recruited patients should receive the endoscopic surgery for picking the olfactory mucosa 1 to 2 months before transplantation. the oecs will be cultured and expanded under the rule of gtp. then, quality control of oecs should be done by immunohistochemical staining positive for gfap, s100, and p75. finally, the investigators will transplanted the oecs (about 2 to 8 x 10´6 cells in saline) into the peri-infarcted area of the brain. (2) combination with traditional drug therapy (such as used the anti-thrombosis reagent or anti-platelet aggregation reagent). (3) nih-stroke scale (nihss), european stroke scale (ess), european stroke motor subscale (ems), barthel index(bi) and mmse will be performed for each patient to evaluate the therapeutic effect as the primary end points. (4) in addition, mri(dti) \& tms(mep) will be also checked for each recruitment patient as the secondary end points.

Eligibility criteria:
inclusion criteria: * aged 35-70 year old chronic stroke adult patients, * with stroke history of more than 6 months, less than 60 months, * with stable hemiplegia condition, * nihss score is between 5\~15. exclusion criteria: * patients aged less than 35 or more than 70, * hemorrhage stroke or mri show the occlusion is not in the middle cerebral artery territory, * nihss is not in the range of 5\~15, * pregnant women, * impaired liver function, abnormal blood coagulation, aids carrier, tumors, other special conditions, etc.

Keywords: stroke, stem cell, olfactory ensheathing cells, intracerebral implantation of olfactory ensheathing cells.
3d echo evaluation of the ventricles in sclero associated severe pah

Conditions: Pulmonary Arterial Hypertension

Summary: the aim of the study is to document the left and right ventricular function in patients with sclerodermia associated pulmonal arterial hypertension via 3d echocardiography. the results of this study should help to generate hypothesis for further future studies. the primary hypothesis is that the increased use of modern image guided methods could provide essential aspects for the follow up.

the 3d echocardiography could provide early and detailed information about the changes in the left and right ventricle. the prediction of sclerodermia associated pulmonary arterial hypertension (pah) is rather adverse, so it makes sense to evaluate relevant changes of the left-ventricular longitudinal strain soon to adapt the pah specific therapy accordingly.

Eligibility criteria:
inclusion criteria: * age \>17 * pulmonary arterial hypertension (pah) associated with who group 1 who start a parenteral prostanoid-therapy * written informed consent * prostanoid naive * no change of the pah specific therapy within 3 weeks of the recruitment to the study exclusion criteria: * pregnancy and lactation period * women of child bearing potential who do not use an effective and secure method for birth control * severe chronic kidney insufficiency (glomerular filtration rate \<30), which will remain for more than 3 months * liver-insufficiency child c * life expectancy shorter than the course of the study (for example because of malignant disease
thermal insulation system in inadvertent hypothermia

Conditions: Perioperative Hypothermia

Summary: this study compares the effectiveness of a new layered thermal insulation system (sit-3c) versus the traditional thermal body protection (warmed forced air system) for patients under total knee arthroplasty, during the intra-operative phase.

protecting patients from the cold in the operating room is a complex problem that has encouraged the search for better and more effective thermal protection systems. some disadvantages have been observed in the daily use of the recommended thermal protection system (forced warm air). this study intends to design and evaluate the effectiveness of a three-layer thermal insulation system, comparing its effect with the forced warm air system on temperature variation, shivering incidence and comfort perception, in patients undergoing total knee arthroplasty under neuro-axial anesthesia, during the intra-operative phase. participants are randomly assigned to the experimental group (eg) or control group (cg). the experimental group receives as a skin protection the three-layer thermal insulation system (sit-3c) and the control group receives the usual recommended system (forced warm air). both systems are placed at the entrance to the operating room and held on patients during the entire intra-operative phase.

Eligibility criteria:
inclusion criteria: * patients aged over 18 years, with the diagnosis of gonarthrosis, to undergo total elective knee arthroplasty, under neuroaxial anesthesia, who agreed to participate in the study. exclusion criteria: * with hypothermia or hyperthermia, scheduled for general anesthesia, pregnancy

Keywords: perioperative hypothermia thermal insulation perioperative comfort
mortality of patients undergoing fracture of the upper extremity u femur at the university hospital of amiens

Conditions: Femur Fracture; Morality

Summary: fractures of the upper femur (efsf) represent a major public health problem in the elderly. approximately 1.6 million patients are victims each year of an efsf and this number is increasing as a result of the aging of the population. in a recent amiens retrospective study the mortality was estimated to be 22.5% at 1 year of the fracture. in surviving patients, the impact on loss of autonomy and degradation of quality of life is considerable. the reduction of the incidence of post-operative complications includes the identification of risk factors. no prospective study in amiens has investigated the mortality and the study of the variables involved in the prognosis and long-term mortality of these patients.


Eligibility criteria:
inclusion criteria: * all the patients operated from a fracture of traumatic origin of the esf to the emergency block at the chu of amiens * patients transferred to the chu after being cared for in another structure will be included. * if a patient successively presents a fracture of each upper extremity of the femur outside of a surgical resumption, two inclusions will be realized exclusion criteria: * do not include non-traumatic fractures of the upper end of the femur (pathological fractures: cancer, for example) * fractures of the upper end of the femur associated with polytrauma will not be included.
antibiotic treatment duration (7 vs 14 days) comparison in blood stream infection causes by enterobacteriaceae

Conditions: Enterobacteriaceae Infections; Bloodstream Infection

Summary: the antimicrobial crisis is a real problem. infections produced by multiresistant bacteria are becoming more and more frequent, and available antimicrobial agents are usually scarce. reducing the duration of antimicrobial treatments is one of the most efficient measures to control the antibiotic pressure and to optimise the use of these agents. bloodstream infections produced by enterobacteria (eb) are very frequent, but the optimal duration of antibiotics to treat them is unknown, as long as no clinical trials have been specifically developed to answer this question. basing on expert opinions, the infectious diseases society pf america (idsa) recommends the bacteremia by eb secondary to vascular catheter infections to be treated for 7 to 14 days. this represents a variability of up to 100%. no recommendations have been published regarding the duration of treatment of bacteremia from other sources. the objective of this project is to prove that the 7-day course of treatment for eb bacteremia is more efficient and equally safe than the 14-day scheme.

to achieve theses objectives, we propose this randomized, multicentric clinical trial with a superiority design on the duration of antimicrobial treatment for eb bacteremia in adult patients.

Eligibility criteria:
inclusion criteria: * adults patients (equal or over 18 years old) * primary or secondary bloodstream infection produced by enterobacteriaceae * source of bacteremia properly controlled or expect to be properly controlled in the next 24 hours (i.e. bacteremia produced by infected vascular catheter, abscess, obstruction of the biliary or urinary tract). * patients able to understand the objectives of the clinical trial and informed consent signed. exclusion criteria: * pregnancy * post-chemotherapy neutropenia expected to persist more than 7 days. * source of bacteremia uncontrolled at inclusion period or in the following 24 hours. the source will be considered as uncontrolled if the bacteremia is secondary to a suppurative infection potentially removable, if no action has been taken to eradicate it, including: bacteremia by vascular not removed catheter, cholangitis secondary to not derived obstruction of the biliary tract, deep abscess not drained, pyohydronephrosis without derivation of the urinary tract. * bacteremia secondary to infective endocarditis, bone and joint infections, or neurosurgical infections, which may require prolonged antimicrobial therapy * bacteremia due to enterobacteriaceae resistant to carbapenemics. * polymicrobial bacteremia including microorganisms different to enterobacteriaceae. * patients with no expectations of survival in the next 48 hours of inclusion.

Keywords: enterobacteriaceae bloodstream bacteremia recurrence reinfection
safety and feasibility of tele-supervised home-based transcranial direct current stimulation in parkinson's disease

Conditions: Parkinson Disease

Summary: the goal of this clinical trial is to learn whether home-based transcranial direct current stimulation (tdcs) is safe and practical for people aged 40 to 70 years with parkinson's disease. the study aims to find out if participants can use the tdcs device at home without serious side effects and whether it is easy for them to use on their own. participants will first attend an in-person visit to learn how to use the tdcs device. they will then use the device at home once a day for 20 minutes over seven consecutive days. video calls on days 2 and 3 will provide support and supervision. after each session, participants will complete brief online questionnaires about any side effects and how easy the device was to use. the study will also check if using tdcs at home improves motor symptoms in parkinson's disease by using a standard movement assessment.


Eligibility criteria:
inclusion criteria: * patients with the diagnosis of parkinson's disease, aged between 40 and 70, who provide verbal and written informed consent will be included. patients should have access to a computer system for video calls and completing the questionnaires, and they must be able to use it. exclusion criteria: * psychiatric symptoms such as moderate or severe depression * cranial metal implants * cardiac pacemaker * epilepsy, stroke * substance abuse * inability to adjust the neoprene cap with the electrodes independently due to movement disturbances

Keywords: brain stimulation parkinson movement disorder non-invasive brain stimulation
insights icd registry

Conditions: Ventricular Tachycardia; Ventricular Fibrillation

Summary: the purpose of the registry is to collect data on how implantable cardioverter defibrillator (icd) therapies and medications are being used by physicians to treat ventricular arrhythmias in order to better understand how to improve the clinical care of patients and effectiveness of icd therapies.


Eligibility criteria:
inclusion criteria: * patients 18 years of age or older. * patients or legal guardians who are willing and able to sign a permission for access to and use of health information in a registry form and, if required by an institution's irb, an informed consent. * new or replacement implants of medtronic market released single, dual or triple chamber icds including: gem vr, gem dr, gem iii at, marquis vr, marquis dr, maximo dr, maximo vr, insync icd, insync marquis icd and insync ii marquis icd. exclusion criteria: * patients enrolled in a device study which effects programming and or treatment.

Keywords: icd registry ventricular tachycardia ventricular fibrillation
the effectiveness of radial eswt on upper trapezius mtrps

Conditions: Myofascial Pain Syndrome; Myofascial Trigger Point Pain; Upper Trapezius Trigger Points

Summary: this study looked after the effectiveness of radial eswt on upper trapezius mtrps. there were three intervention groups which recieved either eswt or standard care. vas, ppt, neck rom and cervical functionality were the main outcomes.

this study was a randomized controlled trial consisted of three intervention groups. two of them recieved eswt with different parameters in each group, while the third one was standard care recieving ultrasound therapy, therapeutic massage and heat packs participants were divided randomly into the three groups. participants were blind to the group allocated and also the therapist and outcome investigator were blind. the participants recieved three weekly sessions. the evaluation took place before therapy, after each session and one month after last session. the outcome measures was the pain intensity with vas, the pain tolerance to pressure by an algometer device, the range of motion of neck measured by electronic goniometer and and functionality of neck measured by the northwick park neck pain

Eligibility criteria:
inclusion criteria: * pain between shoulder and neck on upper trapezius muscle * three out of five of travel and simons criteria for myofascial trigger points exclusion criteria: * fibromyalgia diagnosis * systemic diseases diagnosis, * pacemaker, under 18, * any kind of cervical disorder or surgery, * mental disorders

Keywords: myofascial trigger points upper trapezius myofascial pain syndrome mtrps