Kornimate/medical-research-clean huggingface dataset:
feasibility of an individualized goals of care discussion guide for advanced breast cancer

Conditions: Breast Cancer

Summary: this research study is evaluating whether asking patients to fill out a brief survey about their goals and preferences for care and giving this survey to their clinician before the next visit helps improve communication and decision-making in breast cancer care.

the purpose of this study is to understand patient preferences for communication and decision-making for advanced breast cancer. the investigators want to better understand what topics the participant wants their doctors and nurses to address with the participant in clinic, and the investigators want to evaluate whether asking patients to fill out a brief survey about their goals and preferences for care and giving this survey to their clinician before the next visit is a good idea that helps to improve communication and decision-making in breast cancer care.

Eligibility criteria:
inclusion criteria: * age ≥ 18 * diagnosed with stage iv breast cancer within the past 3 years * receiving care at the mgh cancer center * verbal and written fluency in english * within 6 weeks of a new line of breast cancer therapy and/or progression on scans and/or a change in current breast cancer therapy regimen exclusion criteria: * unwilling or unable to participate in the study * is medically or otherwise unable to participate (as determined by a physician or study pi) * enrolled in hospice

Keywords: breast cancer
factors influencing occurrence of bile leaks in surgery

Conditions: Bile Leak; Anastomotic Leak Biliary; Biliary Tract Fistula

Summary: the objective of our study is to identify the factors influencing the occurrence of a biliary leak after performing surgery leading to the creation of a biliary anastomosis to any segment of the digestive tract.

the objective of our study is to identify the factors influencing the occurrence postoperative of biliary leaks, sex, age, bmi, bilirubin level, protein level, and surgical technique (and other factors)are analyzed to study their influence on occurrence of postoperative biliary leak.

Eligibility criteria:
inclusion criteria: * any patient who has undergone a surgical bilioenteric anastomosis for any etiology. exclusion criteria: * any patient who has undergone a nonsurgical (endoscopic / radiological) bilioenteric anastomosis. * subjects under the age of 18. years. * subjects who refused to participate in this study. * cases of biliary and pancreatic anastomoses performed during the same surgery.

Keywords: hepatobiliary surgery morbidity leak anastomosis
online education and counseling regarding gynecological examination

Conditions: Gynecological Disease

Summary: this research was carried out to determine the effect of online education and counseling on women's attitudes and anxiety levels regarding gynecological examination. the research is a pre-test-post-test, randomized controlled experimental study.

the research is a pre-test-post-test, randomized controlled experimental study. simple randomization method was used to assign the participants to the groups. the sample consisted of a total of 100 women (experimental group: 50 women and control group: 50 women). the study was carried out with women who applied to aydın adnan menderes university application and research hospital, gynecology clinic, gynecology outpatient clinic and met the study criteria.

Eligibility criteria:
inclusion criteria: * applying to aydın adnan menderes university application and research hospital, gynecology clinic, gynecology clinic, * coming to the examination within the first 3 months after the examination, * internet access, * having a whatsapp or e-mail address, * able to read and write, * able to speak and understand turkish, * women in the 18-50 age group are included. exclusion criteria: * having a communication (speech, hearing, etc.) disability, * having any psychological illness, * pregnant and postpartum, * diagnosed with cancer, * women who received infertility diagnosis and treatment were excluded.

Keywords: gynecological examination attitude anxiety online education counseling
control of colic in infants by dietary supplementation with the probiotic lactobacillus reuteri

Conditions: Colic

Summary: it is believed that probiotic lactobacillus reuteri will improve the symptoms of breast-fed infants with colic.


Eligibility criteria:
inclusion criteria: * ifants aged between 14 and 60 days * breast fed, exclusively during length of trial * diagnosis of infantile colic according to wessel's criteria i.e paroxysmal fussing in infancy for more than three hours per day, at least three days per week. * debut of colic symptoms 6+/-1 days before randomization * gestational age between 37 and 42 weeks * apgar score higher than 7 at 5 minutes * mothers willing to follow a cows mild-free diet (free from mild, yoghurt, cheese etc) during the study period * written informed consent from one or both parents * stated availability throughout the study period exclusion criteria: * major chronic disease * gastrointestinal disease but controlled gerd with or without medication is not an exclusion criteria * administration of anitbiotics the week before randomization * administration of probiotics the week before randomization * participation in other clinical trials

Keywords: colic colic in breast-fed infants
use of specifically designed drills for internal sinus lifting

Conditions: Vertical Alveolar Bone Loss; Sinus Lifting; Implant Therapy

Summary: this study was conducted at ege university, school of dentistry, izmir, turkey. patients enrolled require implant placement to the atrophic posterior maxilla. patients were treated with either the specifically designed drills or the osteotomes. the outcome variables were primary stability, marginal bone loss, implant survival, and patient-reported outcomes. the investigators aimed to compare the treatment outcomes of two different techniques used in dental implant placement with internal sinus lifting.

this prospective, randomized clinical study was conducted at the ege university school of dentistry and department of oral and maxillofacial surgery. patients with atrophic maxillas and at least one tooth loss in this region were included. randomization was performed to assign the patients to study groups. patients treated with internal sinus lift using osteotome and implant surgery were assigned to group 1, and patients treated with internal sinus lift using specifically designed drills and implant surgery were assigned to group 2. at six months postoperatively, the healing cap was inserted during the second stage of surgery. all implants were assessed based on primary stability (using implant stability quotient and torque value), marginal bone loss (as millimeters), and implant survival (as a percentage). also, patient-reported outcomes were collected, including pain (using a visual analog scale), analgesic consumption (number of drugs taken during a week), and oral health impact profile survey).

Eligibility criteria:
inclusion criteria: * unilaterally or bilaterally missing teeth in the posterior maxilla, * residual bone height (4 mm to 6 mm), * completed periodontal and oral hygiene treatment, * american society of anesthesiologists (asa) score of i or ii, * \> 18 years old, * willingness to participate exclusion criteria: * infection or pathology related to maxillary sinus and surgical site, * tooth extraction within six months in the surgical site, * previous maxillary sinus surgery, * parafunction, * medical conditions associated with impaired or delayed wound healing, * smoking habit and alcohol or drug abuse, * pregnancy or nursing
the effects of a mobile health intervention and health coach text messaging on cardiovascular risk of older adults

Conditions: Cardiovascular Diseases; Cardiovascular Risk Factor

Summary: this study, "fitness intensive therapy (get fit) to promote healthy living in older adults", will test a mobile-health based intervention which includes use of a fitbit activity tracker for 3 months, a smartphone application that tracks daily food intake, and one 45 minute counseling session to create personal goals and provide patient education by a health coach; versus get fit+ (the same items) plus personalized text messages focusing on participant's activity and nutrition progress as monitored in the app, from the health coach for 3 months. the investigators will measure the impact on participant's diet, physical activity, clinical outcomes, psychosocial well-being, and engagement.

this study, "fitness intensive therapy (get fit) to promote healthy living in older adults", will test 2 behavioral interventions in community-dwelling older adults (age ≥ 60 years) at intermediate and high risk of cardiovascular disease. 1. get fit: use of a fitbit activity tracker, smartphone application to track daily food intake, one 45 minute counseling session to create personal goals and provide patient education by a health coach; vs. 2. get fit+: use of a fitbit activity tracker, smartphone application to track daily food intake, one 45 minute counseling session to create personal goals and provide patient education by a health coach, and personalized push-only text messages from the health coach based on participant's progress as monitored electronically in the application. each intervention lasts 3 months, with outcomes measured at baseline, 3 months, and 6 months.

Eligibility criteria:
inclusion criteria: * aged 60 or greater * at intermediate (10-20%) or high risk (\>20%) of developing cardiovascular disease (as measured by framingham risk assessment tool) * poor eating behaviors (as measured by block fruit/vegetable/fiber screener) * reduced physical activity (as measured by block adult physical activity screener) exclusion criteria: * cognitive impairment (as measured by mini-cog) that impairs ability to understand consent process, surveys, or use of mobile health devices * chronic drug use * end stage renal, liver, or pulmonary disease * current active cancer (i.e., undergoing active treatment for cancer) * gastrointestinal disease which requires a special diet (e.g. crohn's, celiac, etc).
evaluation of protective pulmonary ventilation by pulmonary ultrasound

Conditions: Assessment

Summary: peri - operative ultrasonography was used to evaluate the effects of protective lung ventilation on the postoperative lungs of obese patients.the purpose of this study was to apply ultrasound lung ventilation area score to the monitoring of pulmonary complications in patients with postoperative obesity.to verify the reliability and practicability of perioperative lung ultrasound quantitative scoring.

ultrasound lung ventilation area score was applied to monitor the pulmonary complications of patients after obesity operation to verify the perioperative period. the reliability and practicability of quantitative lung ultrasound score to clarify the effect of protective lung ventilation under perioperative pulmonary ultrasound monitoring on obesity patients.to guide the management of mechanical ventilation under general anesthesia and the prevention and treatment of postoperative pulmonary complications

Eligibility criteria:
inclusion criteria: * enrollment of patients aged 18 years or above； * eligible adult patients had an american society of anesthesiologists (asa) physical status classification of i to iv * undergoing elective or expedited nonurgent, noncardiac surgery with general anesthesia exclusion criteria: * patient refusal; * morbid obesity (bmi \>40 kg/ m²); * american society of anesthesiologists (asa) physical status categories iv-v; * previous intrathoracic procedure; * severechronic obstructive pulmonary disease (forced expiratory volume in 1 s \<30% of the predicted value; * a contraindication to radial artery cannulation.

Keywords: lung ultrasound protective pulmonary ventilation postoperative pulmonary complications
targeted pharmacological and behavioral treatments for smoking in schizophrenia study 1

Conditions: Tobacco Dependence

Summary: schizophrenia is associated with high rates of cigarette smoking and associated morbidity and mortality. in this study, smokers with schizophrenia will complete a baseline session and then randomized to varenicline (var) or placebo (pla). after 1 week on medication, participants will complete a cigarette rating task session. participants will then undergo a 72-hr abstinence period in which they will come to the laboratory twice per day and receive high-value cash reinforcement contingent upon meeting a strict breath co abstinence criterion. at each visit, they will rate withdrawal symptoms, mood and craving. at the end of the abstinence period, they will repeat the cigarette rating task. participants will return to the lab to provide a co sample 24 hours later, and will text the lab with videos of their co samples for one week. date and time of smoking relapse will be measured from these samples.


Eligibility criteria:
inclusion criteria: 1. men and women 2. ages 18-65 3. have schizophrenia or schizoaffective disorder 4. would like to quit smoking within the next 6 months 5. have smoked at least 10 cigarettes per day in the past year 6. have breath co level \> 10 ppm 7. able to speak, read and comprehend english well enough to complete study procedures exclusion criteria: 1. pregnant, breast-feeding, or unwilling to use medically-approved contraception 2. currently using varenicline, bupropion or nicotine replacement therapy for smoking cessation 3. medical disease that would preclude participation 4. unstable psychiatric conditions 5. body mass index (bmi) \ 38 kg/m2 6. past-month suicidal intention, with or without a specific plan 7. positive urine drug screen or breath alcohol level \> 0.01% at screening
postoperative artificial nutrition after pancreaticoduodenectomy

Conditions: Pancreatic Disease

Summary: pancreaticoduodenectomy is a major surgery burdened by important morbidity and mortality partially related to the altered nutritional status of the patients. the perioperative malnutrition is a major risk factor of postoperative complications and worsens the prognosis of the patients. the perioperative artificial nutrition has for objectives to correct the preoperative malnutrition, and to maintain the nutritional status in the post-operative period. the current guidelines in surgery are in favour of a realisation of a perioperative artificial nutrition support that privilege the enteral nutrition. however, after pancreaticoduodenectomy, the total parenteral nutrition remains most usually used in the early postoperative period, although rare studies suggest a benefit of the enteral nutrition in term of reduction of the post-operative complications. indeed, no recommendation was formulated concerning early enteral nutrition after pancreaticoduodenectomy because few studies were realized on its profits. the data of the literature report rates of complications (essentially major) from 49 % to 59 % after major digestive surgery (not only pancreatic) on patients having received a total parenteral nutrition versus rates from 34 to 43.8 % in patients having received an early enteral nutrition. a preliminary prospective study realized in the investigators centre showed a rate of 74 % complication versus 44 %, respectively in the total parenteral nutrition and early enteral nutrition groups (50 patients in every group, with p \< 0.01. all the complications were listed prospectively). hypothesis : the early enteral nutrition will allow, after pancreaticoduodenectomy, a decrease of, at least, 19 % complications of any stage according to the classification of dindo-clavien (59 % versus 40 %).


Eligibility criteria:
inclusion criteria: * male or female patients more than 18 years of age. * pancreatic surgery by pancreaticoduodenectomy. * patient affiliated to a mode of the social security or receiving of such a mode. * having given written informed consent prior to any procedure related to the study exclusion criteria: * asa score ≥4 * pregnant women * patient who cannot give written informed consent. * concomitant participation in a biomedical study being able to interfere with this research * patient less than 18 years of age or more than 18 years of age, protected by the law, under guardianship

Keywords: postoperative artificial nutrition parenteral nutrition enteral nutrition postoperative complications cephalic pancreatoduodenectomy
evaluating the effectiveness of point-of-care diagnostic technologies in mch services in mozambique

Conditions: HIV; Syphilis; Anemia During Pregnancy

Summary: the general goal of the proposed study is to evaluate the cost-effectiveness of poc technologies for diagnosis of syphilis, quantitative analysis for hemoglobin and cd4 counting performed within mch services to improve maternal and infant health. a prospective, quasi-experimental study will be done in cabo delgado province, where health facilities will be randomized in an intervention or comparison arm. outcomes on maternal and infant health will be measured.


Eligibility criteria:
inclusion criteria: * first antenatal care visit * able to provide informed consent and signed consent form * minimum 18 years of age * diagnosed hiv positive at antenatal care visit * living in the catchment area of the health facility exclusion criteria: * age \<18 years * no consent form signed * being on art at time of first antenatal care visit

Keywords: pmtct hiv syphilis anemia during pregnancy point of care diagnostics
evaluation of swallowing impairment after tonsillectomy

Conditions: Swallowing Impairment After Tonsillectomy

Summary: the investigator will evaluate the swallowing pattern of the patients pre-operative and will follow them up at day 15 after tonsillectomy by using careful history taking and fiberoptic endoscopic evaluation of swallowing (fees).

all patients will be evaluated pre-operative by history taking using the arabic version of eating assessment tool (eat-10) questionnaire and will be examined by fiberoptic endoscopic evaluation of swallowing (fees). all patients will be operated by the same surgical technique. patients will be directed to return back on the 15th day post-operative after tonsillectomy and they will be subjected to history taking using the arabic version of eating assessment tool (eat-10) questionnaire and they will be examined by fiberoptic endoscopic evaluation of swallowing (fees). 1. careful history taking the history of the patients will be taken using the arabic version of the eating assessment tool (eat-10) questionnaire. the patient will rate the problem on a scale of 0 to 4 (0 means no problem; 4 means severe problem). a score of 3 or more on the eat-10 is considered dysphagia. 2. fiberoptic endoscopic evaluation of swallowing (fees). using flexible endoscopy (the flexible nasopharyngeal video-fiberscope henke-sass-wolf, 4.3mm in diameter connected to lemke video camera). the patient will be given a colored thin fluid to keep in their mouth and then swallow following the instructions of the examiner, then the examination will be repeated using semisolids (1 teaspoon of yogurt) and using solids (piece of bread). the evaluation of swallowing will involve four items: early spill of food (delayed triggering), aspiration, penetration, and retention (residue). and the results will be recorded.

Eligibility criteria:
inclusion criteria: 1. patients undergoing tonsillectomy. 2. age group (from 7-18 years). 3. patients of either gender. exclusion criteria: 1. patients younger than 7 years or older than 18 years. 2. patients with neurological diseases and genetic syndromes. 3. patients with history of swallowing disorders prior to tonsillectomy.
early reassessment of intravenous antiinfective therapy due to "antiinfective reminders" (air study)

Conditions: Infection as Complication of Medical Care

Summary: switching from intravenous application of antiinfective agents to oral therapy is often performed late including high costs and risk of complications. this study will investigate the impact of displayed reminders in the electronic patient chart after 60h of intravenous therapy with an antiinfective agent.

switching from intravenous application of antiinfective agents to oral therapy is often performed late including high costs, risk of complications as well as higher workload on nursing. this study will investigate the impact of displayed reminders in the electronic patient chart after 60h of intravenous therapy with an antiinfective agent.

Eligibility criteria:
inclusion criteria: * all in-patients in treatment with an intravenous antiinfective for \>60h, * hospitalized in a ward with computerized physician order entry (cpoe) exclusion criteria: * outpatients, * ward without cpoe, * no intravenous antiinfective treatment

Keywords: early reassessment of intravenous antiinfective therapy
study of lithium carbonate to treat niemann-pick type c1 disease

Conditions: Niemann-Pick Disease, Type C1

Summary: this study is planned to study whether lithium carbonate has protective effect on the brain of niemann-pick disease type c1.


Eligibility criteria:
inclusion criteria: 1. aged from 7 years to 40 years 2. onset of neurological symptoms prior to 15 years of age 3. confirmed diagnosis of npc1 determined by either two npc1 mutations or one npc1 mutation with elevated plasma 7-ketocholesterol 4. ability to walk either independently or with assistance 5. subject or parent/guardian able to communicate with investigator, understand and abide the rules of this clinical trial. 6. parent/guardian able to accompany the subjects to participate in the clinical trial 7. subject or parent/guardian must provide written informed consent exclusion criteria: 1. one npc clinical severity scale score reached 5 2. female in pregnancy or breastfeeding 3. the predicted life span less than 1 year 4. severe liver insufficiency (defined as hepatic laboratory parameters, ast and/or alt greater than three-times the upper limit of normal 5. renal insufficiency, with the serum creatine greater than 1.5 times the upper limit of normal 6. free with neurological symptoms 7. take antidiuretic hormone