Kornimate/medical-research-clean huggingface dataset:
combination of percutaneous screw fixation and cementoplasty for lytic bone metastases

Conditions: Interventional Radiology

Summary: in oncology, therapeutic progress has allowed a significant increase in life-expectancy: a growing number of cancer survivors live to more advanced metastatic stages. consequently, the prevalence of secondary bone lesions is increasing, which are frequent and disabling. they are responsible for pain and a high risk of pathological fractures. the average prevalence of pain in cancer represents 53% for all stages combined and 64% for metastatic stages. analgesics, radiotherapy and surgery are widely used in this context, but are not without side effects. cementoplasty is an interventional radiology procedure that has improved the palliative management of bone lesions. it consists of a percutaneous injection of polymethylmethacrylate-based cement, whose physical and chemical properties provide resistance to compressive stress during weight-bearing activities. however, one of the main disadvantages of cement is its low resistance to torsional stress, as evidenced notably in vitro tests. thus, cementoplasty alone is very effective at the spinal level (compressive forces) to reduce pain and risk of fracture, but much less effective at the level of other bones that are subjected to torsional stresses, notably the pelvis and femur (40% fracture rate at one year after cementoplasty alone of femoral metastasis). fixation using a combination of metal screws and cement provides resistance to torsional and compressive stress. in addition, it has been shown that there is a significant risk of secondary screw displacement if screws are not combined with cement in secondary bone lesions. combination of percutaneous screw fixation and cementoplasty is a mini-invasive procedure which allows limiting complications and the duration of treatment: early standing up, almost no blood loss, reduced risk of venous thromboembolism (vte), rapid healing.

the aim of this prospective study is to evaluate feasibility, safety, and efficacy of combination of percutaneous screw fixation and cementoplasty for lytic bone metastases.

Eligibility criteria:
inclusion criteria: * patients who received osteosynthesis/cementoplasty for lytic bone metastases exclusion criteria: * patient's refusal to participate

Keywords: screw fixation cementoplasty interventional radiology pain management
does concurrent hydrocortisone with venlafaxine xr speed antidepressant response?

Conditions: Depressive Disorder, Major

Summary: the primary purpose of this study is to examine whether iv hydrocortisone can speed up the time required for venlafaxine xr to work.

participants will be treated with venlafaxine xr for 6 weeks. the dose of venlafaxine xr will begin at 37.5 mg/day and be gradually increased to a maximum of 225 mg/day. the dose may be kept as low as 75 mg/day if necessary. study doctor will be assessing mood to determine if some patients respond more quickly than the several weeks often required for an antidepressant to begin working. on the first day of treatment with venlafaxine xr, participant will be randomly assigned (similar to a flip of a coin) to receive hydrocortisone 15 mg /day or placebo for two days. placebo is an inactive substance, like a sugar pill. this dose of hydrocortisone is less than a typical replacement dose for patients who are not producing cortisol (hydrocortisone) naturally. the hydrocortisone is administered intravenously (in a vein) over the course of 2 hours for two consecutive days. neither participant nor study doctor will know which treatment participant is receiving. however, this information is available to study doctor if it is needed.

Eligibility criteria:
inclusion criteria::- outpatients at least 18 years of age * current major depressive episode * hdrs greater than or equal to 21 * good physical health exclusion criteria:- history of sensitivity, intolerance, or non-response to venlafaxine * history of sensitivity to hydrocortisone * history of bipolar 1 illness * meets dsm-iv criteria for a current or past psychotic disorder * meets dsm-iv criteria for substance abuse or dependence in previous 6 months * significant imminent suicide risk * medical condition that would compromise participation in the study * woman of child bearing potential not using adequate birth control in the opinion of the investigator
phase ii, 2nd line melanoma - rand monotherapy

Conditions: Melanoma

Summary: the main purpose of this study is to estimate the proportion of patients with a type of skin cancer called melanoma who are progression free, (that is, the cancer has not gotten substantially worse), when treated with anti-cd137 (4-1bb) (bms-663513) at 0.1 mg/kg, 1 mg/kg or 5 mg/kg every 3 weeks or 1 mg/kg every 6 weeks


Eligibility criteria:
inclusion criteria: * subjects must have been previously treated with one line of systemic anti-cancer therapy (non-experimental or experimental) for metastatic disease, and relapsed, failed to respond (cr or pr) or did not tolerate that regimen. if the treatment has been administered as an adjuvant and/or neoadjuvant therapy, the subject must have documented disease progression from the last treatment and also received one additional line of systemic therapy for metastatic disease. * men and women, who are at least 18 years of age exclusion criteria: * ocular or mucosal melanoma * complete surgical resection of all identifiable sites of disease * symptomatic brain metastasis. subjects with signs or symptoms suggestive of brain metastasis are not eligible unless brain metastases are ruled out by computerized axial tomography (ct) scan or magnetic resonance imaging (mri). subjects with stable brain metastasis and those who were previously treated with radiotherapy or surgery must have no current evidence of symptomatic brain metastasis and are off steroid therapy for at least 4 weeks prior to randomization
spinal cord stimulation for spinal cord injury patients - regain walk and alleviate pain

Conditions: Spinal Cord Injury

Summary: the study aims to examine the plausible interventional mechanisms underlying the effects of epidural spinal cord stimulation.

the purpose of this study is for the treatment of spinal cord injury (sci) paralysis patients use the signal by electrophysiological analysis of epidural spinal cord stimulation (scs) settings that promote lower limb activity so that sci patients can restore the ability to stand and walk under multiple sensory stimuli and multimodal electrical stimulation rehabilitation. the investigators hope to establish an atresia nerve regulation strategy and observe that the original blocked neural circuits can improve nerve plasticity by scs. even can establish new connections through residual nerves and allow sci patients to rebuild neural circuits without scs to restore lower limb mobility and improve quality of life.

Eligibility criteria:
inclusion criteria: * sci asia: a, b, c,d * between 20 and 70 year of age * \>1 year post sci * complete or incomplete spinal cord injury. * expected will undergo spinal cord stimulation surgery. * continued rehabilitation after surgery for spinal cord injury. * able to comply with procedures and follow up. * stable medical condition without cardiopulmonary disease or dysautonomia that would contraindicate participation in lower extremity rehabilitation or testing activities exclusion criteria: * have significant cognitive impairment (mmse\<24). * had a mental illness within one year or been treated in the past. * have major depressive disorder. * active cancer diagnosis. * painful musculoskeletal dysfunction, unhealed fracture, contracture, pressure sore, or urinary tract infection that might interfere with stand or step training. * cardiovascular or musculoskeletal disease or injury that would prevent full participation in physical therapy intervention. * unable to read and/or comprehend the consent form. * have concerns about this trial and do not sign consent.
extinction learning in adults with tourette syndrome

Conditions: Tourette Syndrome; Habit Reversal Training; Tic Disorders; Tics; Comprehensive Behavioral Intervention for Tics

Summary: aversive sensory phenomena such as premonitory urges play a central role in the behavioral treatment model of tics. extinction learning and extinction recall are learning processes implicated within this model, but are still understudied for individuals with tourette syndrome (ts). this study examines extinction learning and extinction recall in adults with ts using an experimental task. this study will also explore the relationship between extinction processes (i.e., extinction learning and extinction recall) and treatment outcomes with behavior therapy. findings from this investigation will be used to update the behavioral treatment model, which serves as the basis for evidence-based behavioral interventions.


Eligibility criteria:
inclusion criteria: * at least 18 years old, * have moderate tic severity or greater as evidenced by a ygtss total tic score greater than 13 (\>9 for youth with motor or vocal tics only) * have not received more than 4 previous sessions of hrt * be fluent in english * medication free or on a stable dose of psychiatric medication for 8 weeks prior to enrollment. exclusion criteria: * an inability to complete rating scales * an inability to attend study visits

Keywords: extinction learning comprehensive behavioral intervention for tics behavior therapy habit reversal training tourette's disorder
study of urgent pc versus sham effectiveness in treatment of overactive bladder symptoms

Conditions: Overactive Bladder

Summary: the purpose of this study is to demonstrate superiority of percutaneous posterior tibial nerve stimulation (ptns) therapy compared to sham therapy for the treatment of patients with overall bladder (oab) symptoms.


Eligibility criteria:
inclusion criteria: * women and men \>18 years of age * a score of \> 4 on the oab-q short form for urgency (question 1) * average urinary frequency \> 10 times in one 24 hour day based on a 3-day voiding diary * self-reported bladder symptoms present \> 3 months * self-reported failed conservative care (i.e., dietary restriction, fluid restriction, bladder training, behavioral modification, pelvic muscle training, biofeedback, etc.) * off all antimuscarinics for at least 2 weeks prior to enrollment * capable of giving informed consent * ambulatory and able to use a toilet independently, without difficulty * capable and willing to follow all study-related procedures exclusion criteria: * pregnant as confirmed by urine pregnancy test, or plans to become pregnant during the study period * neurogenic bladder * botox use in bladder or pelvic floor muscles in the past year * pacemakers or implantable defibrillators * primary complaint of stress urinary incontinence * current urinary tract infection (uti) * current vaginal infection * current use of interstim * current use of bion * current use of tens in the pelvic region, back or legs * previously been treated with ptns * use of investigational drug/device therapy within the past 4 weeks * participating or have participated within the past 4 weeks in any clinical investigation involving or impacting gynecologic, urinary or renal function * deemed unsuitable for enrollment in study by the investigators based on subjects' history or physical examination (including bleeding disorders or anticoagulant medications, and peripheral neuropathy) * subjects with nerve damage that would impact either percutaneous tibial nerve or pelvic floor function

Keywords: overactive bladder
probiotics effects to initial periodontal treatment

Conditions: Chronic Periodontitis

Summary: the aim of this study is to evaluate the clinical and microbiological effects of bifidobacterium animalis subsp. lactis dn-173010 containing yoghurt as an adjunct to mechanical periodontal treatment.

the aim of this study is to evaluate the clinical and microbiological effects of bifidobacterium animalis subsp. lactis dn-173010 containing yoghurt as an adjunct to mechanical periodontal treatment. thirty chronic periodontitis patients were randomized into 2 groups. as adjunctive to mpt, group 1 consumed 2×108 cfu/day of bifidobacterium animalis subsp. lactis dn-173010 containing probiotic yoghurt while group 2 natural yoghurt once daily for 28 days. subgingival plaque samples were obtained from 2 periodontal sites with probing pocket depth (ppd) of 4≤ppd\<7 mm via paper-points at baseline, 28th day, 3rd month. samples were cultured to evaluate total viable count (tvc), the proportions of obligate anaerobes (oa) and bifidobacterium species (b) (tvc%). the full-mouth recorded clinical parameters were plaque index, gingival index, ppd, bleeding on probing, and clinical attachment level.

Eligibility criteria:
inclusion criteria: * chronic periodontitis patients with radiographically detected horizontal bone loss * the presence of at least 2 teeth with one approximal site with a probing pocket depth (ppd) of 4≤sd\<7 mm (5-7 mm) and a gi of ≥2 mm in each quadrant, * previously untreated periodontitis, systemically healthy exclusion criteria: * systemic diseases * antibiotics and anti-inflammatory drugs within 3 months before the study * untreated caries lesions or local retention factors * allergic reactions to lactose or fermented milk products * previous probiotic supplements in diet * smoking * pregnancy

Keywords: bifidobacterium chronic periodontitis dental scaling probiotic root planing
evaluation of the efficacy and safety of microwave ablation of uterine adenomyosis under improved ultrasound guidance

Conditions: Adenomyosis of Uterus

Summary: this study aims to compare the safety and efficacy of segmental power adjustment combined with uterine cavity hydro-isolation in microwave ablation of adenomyosis


Eligibility criteria:
inclusion criteria: 1. ufs or am diagnosed by pathology and ultrasound； 2. relevant symptoms such asabnormal uterine bleeding, secondary anemia, progressive dysmenorrhea and enlargement of the uterus； 3. voluntarily undergo mwa； 4. a confirmed available safe transabdominal puncture path； exclusion criteria: 1. pregnancy or malignancy； 2. severe and uncorrectable coagulation disorders； 3. severe cardiac, liver, and renal dysfunction； 4. anesthesia allergy.
weuskop6166: lamotrigine and aseptic meningitis

Conditions: Epilepsy

Summary: the objective of the study is to quantify the number of cases of aseptic meningitis among users of lamotrigine. this study is a cross-sectional study design using data on lamotrigine patients within the thomson reuters marketscan® commercial database (marketscan database). the marketscan database is a us-based insurance claims database representative of a us insured population and includes supplemental datao n medicare patients. this cross-sectional study will evaluate the number of cases of aseptic meningitis among lamotrigine users during the duration of lamotrigine therapy, with an extended exposure window of 30 days after completing therapy. the marketscan® database is an us insurance claims database that is held in-house at gsk, which can be interrogated to examine rates of prescribing and medical conditions that can be captured via icd-9 diagnoses codes. the marketscan database captures person-specific clinical utilization, expenditures, and enrollment across inpatient, outpatient, prescription drug, and carve-out services from a selection of large employers, health plans, and government and public organizations. the annual medical databases include private sector health data from approximately 100 payers. in 2011, there were approximately 35 million patients on the database. the commercial claims and encounters database represents the medical experience of insured employees and their dependents for active employees, early retirees, cobra continues, and their dependents insured by employer-sponsored plans (i.e., non-medicare eligibles). in addition, a linked medstat medicare database contains predominantly fee-for-service plan data in insurance plans where both the medicare-paid amounts and the employer-paid amounts were available and evident on the claims.the data are hipaa compliant thus all patients have been anonymized.


Eligibility criteria:
inclusion criteria: * patients must be using lamotrigine for epilepsy or bipolar disorder. * patients must have at least 180 days history on the database prior to the index of lamotrigine use. * patients must have medical and pharmacy coverage throughout the study, with no gaps in eligibility. exclusion criteria: * none

Keywords: aseptic meningitis epidemiology bipolar disorder lamotrigine epilepsy
correlation between parameters and prognosis of cervical single open-door surgery

Conditions: Cervical Spinal Stenosis

Summary: the aim of study was evaluated the relationship between the relevant evaluation indexes of cervical spine open-door surgery, prognosis and complication rate, and provided theoretical basis for personalized surgical program through multi-center retrospective clinical study


Eligibility criteria:
inclusion criteria: * symptoms and signs of the patients were typical. mri showed single or multiple central herniation of c3-c7 intervertebral discs or spinal stenosis at corresponding levels, which confirmed cervical myeloid cervical spondylosis or cervical spinal stenosis. * conservative treatment for more than 3 months before surgery was ineffective. * the patients underwent cervical single open-door surgery. * informed consent was obtained from the patient and his family, informed consent was signed, and a complete follow-up was completed after surgery exclusion criteria: * cervical spondylotic radiculopathy. * cervical kyphosis or instability. * cervical spondylosis caused by trauma, tumor, tuberculosis and metabolic diseases. * revision surgery or combined anterior-posterior surgery is required. * the patients had severe neurological diseases affecting the evaluation of postoperative results. * psychopath. * mri or ct for contraindications.

Keywords: cervical single open-door surgery cervical spinal stenosis open angle
the impact of distraction on adenoma detection rate

Conditions: Adenoma

Summary: the investigators will review video-recordings of three randomized, controlled trials (nct01535326, 01699399, and 01894191) comparing air insufflation, water immersion and water exchange during colonoscopy. these studies were all conducted at buddhist dalin tzu chi hospital.

the investigators will review video-recordings of three randomized controlled trials (nct01535326, 01699399, and 01894191) comparing air insufflation, water immersion and water exchange. these studies were conducted at buddhist dalin tzu chi hospital. permission will be obtained from the local institutional review board (irb) to review, analyze and report de-identified findings. two experienced endoscopists (yhh and cwt) performed all the recorded colonoscopies. recordings will be selected for review if they are complete examinations; include clear identification of the appendiceal orifice and/or the ileocecal valve, indicating arrival at the cecum; available in the appropriate format for video editing; and contain no patient or endoscopist identifiers. patients with incomplete recordings and a history of bowel resection will be excluded from analysis. the included video recordings will be edited to remove the insertion phase to blind the study reviewer to the insertion techniques. one blinded reviewer uninvolved in the performance of the colonoscopies will be in charge of evaluating the selected videos, using the criteria described by yung et al

Eligibility criteria:
inclusion criteria: * if they are complete examinations; include clear identification of the appendiceal orifice and/or the ileocecal valve, indicating arrival at the cecum; available in the appropriate format for video editing; and contain no patient or endoscopist identifiers. exclusion criteria: * patients with incomplete recordings and a history of bowel resection will be excluded from analysis.

Keywords: colonoscopy water exchange adenoma detection rate distraction
dominican republic mission cost analysis

Conditions: Hernia; Hydrocele

Summary: expenditures on material supplies and medications constitute the greatest per capita costs for surgical missions. we hypothesized that supply acquisition at nonprofit organization cost would lead to significant cost-savings compared to supply acquisition at us academic institution costs from the provider perspective for hernia repairs and minor procedures during a surgical mission in the dominican republic.


Eligibility criteria:
inclusion criteria: * patients presenting to the institute of latin american concern center for surgical procedure, previously screened by local healthcare workers. * require hernia surgery, hydrocelectomy, excision of benign cutaneous mass. exclusion criteria: * did not require hernia surgery, hydrocelectomy, excision of benign cutaneous mass.

Keywords: hernia repair hydrocelectomy global health global disease burden surgical mission dominican republic cost-minimization procedural cost material cost item utilization excision of benign cutaneous mass minor procedure