Kornimate/medical-research-clean huggingface dataset:
a trial of 0.025 wire guided cannulation versus current practice 0.035 wire guided cannulation

Conditions: Abdominal Pain; Post-ERCP Acute Pancreatitis

Summary: the aim of this study is to determine whether using a smaller wire results in a higher success rate at endoscopic retrograde cholangiopancreatography (ercp), and lower incidence of adverse events

cannulation of the bile duct is a prerequisite to successful therapeutic biliary endoscopy. cannulation itself can carry substantial risk to the patient. acute pancreatitis following ercp can occur up to 5% of cases. the risk increases in patients with non dilated bile ducts, young age, known past history of pancreatitis and suspected sphincter of oddi dysfunction. during the procedure of ercp, the number of pancreatograms also correlates with incidence of post ercp pancreatitis. hydrostatic pressure by contrast injection into the pancreatic duct may be the principal cause of pancreatitis. we performed a meta-analysis of randomized controlled trials that compared the technique of contrast guided to wire guide cannulation in achieving bile duct cannulation during ercp and found that wire guide cannulation was better at the prevention of post ercp pancreatitis. the use of a guide wire obviates the need for contrast injection. the current standard is the use of a 0.035" guidewire with a hydrophilic tip. we now postulate that the use of a 0.025" further reduces post-ercp pancreatitis as a finer wire theoretically induces less trauma to the pancreatic orifice.

Eligibility criteria:
inclusion criteria: * all patients referred for ercp who have an intact naïve papilla are considered for inclusion exclusion criteria: * age \<18yrs * acute illness (hypotension: bp\<90mmhg, hypoxia: o2 \<95%, haemodynamic instability) * inability or refusal to give informed consent. * patients with previous sphincterotomy * pancreatic or ampullary cancer are excluded as post-ercp pancreatitis (pep) is very uncommon in these subgroups and tumour-related anatomical variation may alter cannulation technique. (consider substratify results for this subgroup, but exclude if duodenal stenosis precludes an attempt on the papilla) * patients with surgically altered anatomy (bilroth ii gastrectomy and roux en y anastomosis) are excluded as cannulation technique is fundamentally different from that in normal anatomy.
microendoscopic lumbar discectomy: a study of 100 cases

Conditions: Lumbar Disc Herniation

Summary: evaluate the outcome of micro endoscopic discectomy (med) by tubular retractors on safety and efficacy of the technique.

evaluate the outcome of micro endoscopic discectomy (med) by tubular retractors on safety and efficacy of the technique.patients who underwent surgery for herniated disc using the tubular retractors. the results were evaluated by using vas (visual analog scale 0-5) for back and leg pain and odi (oswestry disability index). patients were followed up at intervals of 1 week, 6 weeks, 3 months, 6 months, 12 months and 2 years after surgery.

Eligibility criteria:
inclusion criteria: * patients with at least 6 weeks of conservative treatment with positive nerve root tension signs, radicular pain * patients are diagnosed with lumbar disc herniation by mri * patients who underwent surgery for herniated disc using the tubular retractor exclusion criteria: * patients with large central disc herniation, chronic discogenic pain, discitis, multi-level disease, presence of instability or history of lumbar surgery

Keywords: lumbar disc herniation micro endoscopic discectomy
pegylated interferon and ribavirin in hepatitis c virus infection after liver transplantation.

Conditions: Hepatitis C

Summary: the purpose of this study was to evaluate the efficacy (and safety) of antiviral therapy in patients with chronic hepatitis c after liver transplantation. the only approved drugs for treatment of hepatitis c are pegylated interferon and ribavirin.

hepatitis c recurrence after liver transplantation remains the main cause of graft loss after liver transplantation. several strategies can be used to prevent or treat hepatitis c in the setting of liver transplantation. there are no controlled studies evaluating the efficacy and safety of antiviral treatment (using pegylated interferon and ribavirin) in liver transplant recipients. the main endpoint of this study was: 1) histological outcomes (effect of antiviral treatment on disease progression, i.e. liver fibrosis). the secondary endpoint were 1) sustained virological response (persistent hcv-rna clearance) and 2) safety of pegylated interferon and ribavirin

Eligibility criteria:
inclusion criteria: * chronic hepatitis c defined by liver biopsy and presence of hcv-rna * more than 6 months from liver transplantation * written inform consent exclusion criteria: * severe hepatitis c recurrence (f3-f4 fibrosis stage, cholestatic hepatitis) * double liver-kidney transplantation * leucopenia (2000) or thrombocytopenia (40.000) * anemia (hemoglobin lower than 10 g/dl) * renal failure (creatinine \> 2 mg/dl) * autoimmune disease * all contraindications for interferon and ribavirin therapy

Keywords: liver fibrosis portal pressure antiviral therapy
effect of stellate ganglion block on pharyngeal dysphagia after cerebralvascular accident

Conditions: Dysphagia

Summary: this was a multicenter randomized controlled study. 66 post-stroke patients with pharyngeal dysphagia were randomly allocated to the observation group (n=33) or the control group (n=33). both groups were provided with comprehensive rehabilitation including routine rehabilitation and swallowing function training. besides, the observation group additionally underwent the stellate ganglion block (sgb). at admission and after 20-day treatment, kubota water swallowing test, video fluoroscopic swallowing study (vfss), and rosenbek penetration-aspiration scale (pas) were used to assess swallowing function.

dysphagia is a frequent and potentially serious complication of stroke. however, there is no effective measure for the treatment of pharyngeal dysphagia in stroke patients. this study aims to explore the efficacy of stellate ganglion block in post-stroke pharyngeal dysphagic patients who received comprehensive rehabilitation. this was a multicenter randomized controlled study. 66 post-stroke patients with pharyngeal dysphagia were randomly allocated to the observation group (n=33) or the control group (n=33). both groups were provided with comprehensive rehabilitation including routine rehabilitation and swallowing function training. besides, the observation group additionally underwent the stellate ganglion block (sgb). at admission and after 20-day treatment, kubota water swallowing test, video fluoroscopic swallowing study (vfss), and rosenbek penetration-aspiration scale (pas) were used to assess swallowing function.

Eligibility criteria:
inclusion criteria: * age between 30 and 80 years; * new-onset stroke; * the course of disease between 1 to 6 months; * with pharyngeal dysphagia; * stable vital signs; * voluntary participation in the study. exclusion criteria: * allergy to lidocaine injection or vitamin b12 injection; * severe cognitive impairment; * coagulation disorders; * severe dysfunction of organs including heart, lungs, kidney, liver, etc.; * complicated with other neurological diseases; * dysphagia caused by other diseases or reasons.
gingival irritation due to bleaching tray design in an at-home bleaching treatment

Conditions: Gingival Inflammation

Summary: the primary aim of this study is to assess whether the design of the bleaching tray used in at-home bleaching treatment is directly correlated with the risk of gingival irritation. additionally, it aims to investigate whether the design influences the likelihood of dental sensitivity and its impact on the degree of tooth whitening.

visit 1: study information and delivery of informed consent. recording of the patient's medical history, general examination, and prophylaxis. alginate impressions will be taken of the upper and lower arches for all patients who meet the inclusion criteria. the impressions will be poured into plaster, and individualized bleaching trays will be made for each patient according to the predetermined assignment ( 1mm extended or 3 mm extended bleaching tray). a positioning guide tray will be fabricated for color measurement. visit 2: initial color measurement with a spectrophotometer and the positioning guide. each patient will receive their individualized trays. additionally, they will be given 3 syringes of bleaching agent (opalescence 16%, ultradent products). each patient will be provided with an instruction sheet and recording sheets to fill out daily during the 3-week study period. they will record if they had gingival irritation and the degree of dental sensitivity. visit 3: first-week bleaching review. data collection (gingival irritation + color + sensitivity). visit 4: second-week bleaching review. data collection (gingival irritation + color + sensitivity). visit 5: third-week bleaching review and end of the study. data collection (gingival irritation + color + sensitivity).

Eligibility criteria:
inclusion criteria: * no oral or systemic pathology * periodontally healthy * no cavities * tooth shade of the upper and lower canines a2 or darker exclusion criteria: * adhesive restorations or prostheses in the anterior region * enamel or dentin alterations * smoking * pregnant women * undergone prior bleaching treatment

Keywords: tooth bleaching vital bleaching at-home bleaching gingival irritation bleaching tray
pain sensitivity questionnaire applied in preoperative period in lumpectomy

Conditions: Pain Score; Pain Postoperative

Summary: objective: the pain sensitivity questionnaire (psq) is a clinically valuable tool that has been shown to correlate with various experimental pain sensitivity assessments in healthy individuals and patients with chronic pain. in this study, we aimed to investigate the effectiveness of the psq in predicting postoperative pain in patients undergoing breast-conserving surgery.

objective: the pain sensitivity questionnaire (psq) is a clinically valuable tool that has been shown to correlate with various experimental pain sensitivity assessments in healthy individuals and patients with chronic pain. in this study, we aimed to investigate the effectiveness of the psq in predicting postoperative pain in patients undergoing breast-conserving surgery. materials and methods: this study included 74 patients over the age of 18 with american society of anesthesiologists (asa) scores of i, ii, or iii, who were scheduled to undergo breast-conserving surgery. ethical approval from the local ethics committee and written informed consent from each patient were obtained. patient data, including age, asa score, and comorbidities, were collected, and contact details were recorded for postoperative follow-up. the psq was administered to all patients during the preoperative period to assess their pain sensitivity. anesthesia induction and maintenance followed a standardized protocol on the day of surgery. the intraoperative analgesic consumption and the duration of the surgery were documented. postoperative assessments were conducted 24 hours after the surgery in the general surgery ward, where analgesic use and short pain inventory scores were recorded. patients were followed up one month postoperatively, and their pain levels were assessed using the numeric rating scale (nrs).

Eligibility criteria:
inclusion criteria: having planned bcs with general anesthesia * being a female patient between the ages of 18-70 * being evaluated as american society of anesthesiologists (asa) i, ii, iii * having given written consent to participate in the study exclusion criteria: pregnancy * being assessed as asa iv * having advanced cardiac, pulmonary and cerebrovascular disease, advanced renal failure, liver failure, history of fentanyl/remifentanyl hypersensitivity, alzheimer's disease, mental retardation * being at a mental level that cannot comply with the evaluations within the scope of the study * not having given written consent for any reason

Keywords: breast surgery pain sensivity
emergence agitation of sevoflurane in pediatric

Conditions: Emergence Delirium

Summary: low dose nalbuphine versus dexmedetomidine on prevention of emergence agitation in children

the incidence of emergence agitation (ea) varies between 18% and 80. ea occurs most frequently in preschool children during the early stage of emergence from anaesthesia . it is considered a potentially serious postoperative complication that can result in physical harm and removal of intravenous catheters. as such, ea is a source of dissatisfaction for the parents of paediatric patients and their healthcare providers . sevoflurane is an inhalational anaesthetic used widely as a paediatric or outpatient anaesthesia due to its excellent hemodynamic stability and low blood solubility, which allows rapid induction and emergence from general anaesthesia, as well as control of the depth of anaesthesia. however, when sevoflurane is used alone it is associated with a higher incidence of emergence agitation in children. the rapid removal of residual anaesthetics due to low blood solubility of sevoflurane has been suggested to cause emergence agitation in some patients nalbuphine is a semi-synthetic, agonist antagonist opioid analgesic agent that acts as a partial agonist at kappa receptors and an antagonist at µ receptors, has minimal side effects, and exhibits a ceiling effect for respiratory depression . nalbuphine should effectively relieve postoperative pain and decrease the rate of ea in paediatric patients after sevoflurane anaesthesia. dexmedetomidine, a selective alpha 2 agonist, has been shown to reduce the incidence of postoperative agitation with sevoflurane anaesthesia . dexmedetomidine can affect the brain and spinal cord α 2-adrenergic receptor, inhibition of neural discharge to produce sedative, analgesic, and anxiolytic effects. the locus coeruleus is a verified key part of the brain responsible for the regulation of arousal and sleep. dexmedetomidine affects the brainstem locus coeruleus α 2-adrenergic receptors and produces sedative, hypnotic, and anxiolytic effects and it has also anesthetic-sparing effects without significant respiratory depression . this study will be conducted to evaluate the effect of intravenous nalbuphine iv 0.1 mg/kg versus dexmedetomidine iv 0.5 μg/kg on ea in paediatric patients undergoing ent surgeries under sevoflurane anaesthesia.

Eligibility criteria:
inclusion criteria: * age 4 - 10 years. * sex: male and female * patients with asa classification i and ii exclusion criteria: * refusal of the caregiver to give written informed consent. * history of allergy to the medications used in the study. * psychiatric disorder. * asa classification iii - iv. * fever, cough, asthma or upper respiratory tract infection. * surgery more than 2 hours * hearing defect that limits communication. * neurological disorder . * history of malignant hyperthermia. * surgeries more than 2 hours.

Keywords: emergence delirium
a comparative study of the safety and efficacy of face talc slurry and iodopovidone for pleurodesis

Conditions: Malignant Pleural Effusions; Recurrent Pleural Effusions; Primary Spontaneous Pneumothorax; Secondary Spontaneous Pneumothorax

Summary: pleurodesis is a technique used to fuse the two layers of the lining over the lung. this is done to get rid of collections of fluid or air in this space. a common reason would be cancer of the underlying lung or elsewhere causing fluid to collect in the pleural space. in this situation it is a palliative procedure to free the patient from symptoms like breathlessness.

pleurodesis is a technique used to fuse the two layers of the pleura. this is done to prevent reaccumulation of collections of fluid or air in this space. common indications are malignant pleural effusions, recurrent pneumothorax and even benign effusions which are otherwise difficult to eradicate.

Eligibility criteria:
inclusion criteria: * age over 12 years * symptomatic recurrent pleural effusion * pneumothorax needing pleurodesis exclusion criteria: * life expectancy \<1 month * unwilling to give consent * empyema * ictd drain output \>150 ml/d * presence of an airleak

Keywords: pleurodesis talc iodopovidone
tvto versus tvtffm for urinary stress incontinence

Conditions: Urinary Stress Incontinence Treated by TVT

Summary: women who had urinary stress incontinence and underwent one of two procedures: the classic tvto or the folke-flam method of surgical operation, will be evaluated and compared.

we will enroll women that underwent one of the two surgeries: tvto or the modification where the needle passes somewhat to the side to prevent the post operative pain, for urinary stress incontinence. data will be collected from the charts. telephone interviews will be carried out. physical examination will also be incorporated.

Eligibility criteria:
inclusion criteria: * women with urinary stress incontinence treated by tvt exclusion criteria: * women without with urinary stress incontinence or not treated by tvt
clinical evaluation of different bioactive restorative materials for cervical carious in high caries risk patients

Conditions: Class V Dental Caries; High Caries Risk Patients

Summary: the aim of the study is to clinically evaluate three different bioactive restorative material in cervical carious lesion in high caries risk patients. reducing the incidence of recurrent caries is the primary outcome

bioactive restorative materials are relatively new concept in dentistry combines between esthetics, strength and resilience of composites with bioactive properties, the development of therapeutic bio-interactive materials results in tissue re-mineralization, reduces the susceptibility to tooth mineral loss, and recovers its mechanical properties . patients, with high caries, have many risk factors like inadequate biofilm control, salivary flow deficiency, and altered host defense. conventional restorative materials expose the tooth structure to stress concentration. moreover, preserving the tooth restoration interface intact is great challenge to avoid recurrent caries, which may also result in restoration failures . this prospective study will be investigating and comparing the eighteen month clinical performance of a different bioactive restorative materials and a conventional pre-reacted glass ionomer restorative material in class v cavity preparation.

Eligibility criteria:
inclusion criteria: * patient age range from 25-45 year. * high risk caries. * patients required at least a couple of class v restorations. * the depth of lesion should be(1.5- 2 mm) . * the patient should have good general health exclusion criteria: * poor oral hygiene. * sever or chronic periodontal disease or bruxism. * severe tooth sensitivity. * non-vital or fracture or cracked teeth. * defective restorations, orthodontic treatment or bleaching procedures during the last 6 months. * pregnancy, and/or lactation, and allergy to the main components of the products to be used in the study

Keywords: bioactive restorative material dual cure bulk fill bio-active restoration pre-reacted glass ionomer (prg) giomer
observation of blood lipid outcomes in lipid clinic

Conditions: Dyslipidemias

Summary: taipei mackay memorial hospital will establish a lipid clinic for hyperlipidemic patients. in this lipid clinic, the physician will discuss with each individual patient and set an individualized ldl goal according to current guideline and regulation of national health insurance administration (nhia). the aim of this study is to observe blood lipid outcomes in patients who receive treatment in lipid clinic of taipei mackay memorial hospital.

hyperlipidemia is a major risk factor of atherosclerotic cardiovascular disease (ascvd), and therefore it is beneficial to prevent the risk of ascvd by controlling the prevalence of hyperlipidemia. according to cepheus pan-asia survey, the rate of ldl goal attainment in hyperlipidemic patients of taiwan was suboptimal, especially in high-risk patients. 2017 taiwan lipid guideline for high-risk patients has been published and clearly defined the treatment goal of blood ldl-c for high-risk patients. besides, taipei mackay memorial hospital will establish a lipid clinic for hyperlipidemic patients. in this lipid clinic, the physician will discuss with each individual patient and set an individualized ldl goal according to current guideline and regulation of national health insurance administration (nhia). the aim of this study is to observe blood lipid outcomes in patients who receive treatment in lipid clinic of taipei mackay memorial hospital.

Eligibility criteria:
inclusion criteria: * ≥20 years-old * abnormal lipid profiles according to 2017 taiwan lipid guideline for high-risk patients exclusion criteria * reject to participate in this study * pregnant women * prisoner * illiteracy * hiv patients * individuals who are mentally retarded, homeless, and handicapped
a study to investigate the ability to use 18fdg pet scanning to monitor the effectiveness of new drugs in copd patients

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: it is hypothesised that there is a difference between the uptake of a radioactive substance (\[18f\]fluorodeoxyglucose (fdg)) in the lungs of patients with chronic obstructive pulmonary disease (copd) and healthy volunteers.

single site, eligible subjects enrolled in order of presentation.

Eligibility criteria:
inclusion criteria: * copd patients: * subjects with a body mass index (bmi) between 18-32 kg/m2. * patients with a diagnosis, for at least 6 months, of moderate to severe (stage ii - iii) copd as defined by the nih/who global initiative for chronic obstructive lung disease (gold, 2005 revision), whose disease has been stable for 3 months, and have not had a respiratory tract infection for 6 weeks prior to screening. * ability to be maintained off inhaled corticosteroids and other anti-inflammatory medications (e.g., theophylline) as required by the protocol * healthy volunteers: * healthy volunteers should be age (+/- 5 years) and gender matched to the copd subjects * no history of asthma, copd or other lung disease (including, sarcoidosis, pneumoconiosis, tuberculosis, lung surgery or resection, lung cancer, bronchitis). * free from clinically significant disease. exclusion criteria: * exacerbation or hospitalisation for copd within 3 months of screening, or more than twice during the preceding year. * use of oral corticosteroids in the 6 weeks prior to screen. (patients who have been taking inhaled corticosteroids as maintenance copd therapy are eligible provided the dose has remained stable for the previous 6 weeks and it is considered that they could tolerate withdrawal of inhaled corticosteroid for the duration of the study). * a clearly documented history of adult asthma or other chronic respiratory disorders apart from copd (e.g. clinically significant bronchiectasis, pulmonary fibrosis, pneumoconiosis). * previous history of bronchial carcinoma, or previous history of lung surgery (including lung resection, pleurodesis, open lung biopsy, video-assisted lung biopsy) or invasive lung procedure (e.g., bronchoscopy (with or without biopsy), bronchoalveolar lavage). * patients with a history of prior radiation exposure within the past year such that participation this study would put them over 5 rem for annual radiation exposure for research subjects. * history or evidence, based upon a complete medical history, full physical examination, chest x-ray or clinical laboratory test results, of any other significant concomitant clinical disease that, in the opinion of the investigator, could interfere with the subject's safety or the conduct of this study.

Keywords: methodology study, pet imaging, copd patients