Kornimate/medical-research-clean huggingface dataset:
comparative study between pulse therapy with oral itraconazole versus continuous oral terbinafine therapy for treatment of onychomycosis

Conditions: Onychomycosis

Summary: nail fungus, often known as onychomycosis (om), can attack either the toenails or the fingernails. onychomycosis can affect the matrix, the nail bed, or the nail plate. though not fatal, onychomycosis is a significant condition that can impede a person's mobility and ability to work. onychomycosis's wide-ranging emotional and social impacts can have a serious negative impact on patients' well-being. white superficial onychomycosis (wso), proximal subungual onychomycosis (pso), endonyx onychomycosis (eo), and candidal onychomycosis are the most common subtypes of onychomycosis. a patient may exhibit characteristics from more than one of these categories. a severe case of onychomycosis, regardless of its subtype, is called total dystrophic onychomycosis. different types of onychomycosis have different pathophysiology. the most frequent type of onychomycosis, known as distal lateral subungual onychomycosis, occurs when a fungus travels from the plantar skin to the nail bed through the hyponychium. these sections of the nail apparatus become inflamed, leading to the outward manifestations of distal lateral subungual onychomycosis. white superficial onychomycosis, on the other hand, is a less common presentation produced by invasion of the nail plate's surface. fungi colonise the deep section of the proximal nail plate in the rare condition known as proximal subungual onychomycosis. when the fungi infect the nail through the skin and penetrate the nail plate, the result is known as endonyx onychomycosis, a subtype of distal lateral onychomycosis. over and over again, terbinafine has been shown to be more effective than other antifungal medicines in clinical trials. mycological cure rates for onychomycosis were 76% with terbinafine, 63% with pulse itraconazole, and 48% with fluconazole, according to a meta-analysis of 18 studies. the aim of this study is to determine the aim of this study is to compare pulse therapy with oral itraconazole versus continuous oral terbinafine for treatment of onychomycosis


Eligibility criteria:
inclusion criteria: * patients age between 18 and 60 years * patients positive for fungus via direct microscopy due to identification of hyphae or blastospores on the toe nails * patients having positive fungal culture * patients who had not applied any topical agent to the target toe nail for the last one month exclusion criteria: * pregnant patients * lactating women * patients with poor adherence * patients previously allergic to oral itraconazole or terbinafine * patients with elevated baseline lfts such as alt ,ast , alkaline phosphatase and total bilirubin twice the upper limit of normal * history of renal disease * patients unresponsive to systemic antifungal therapy with in the past year * history of using systemic immunosuppressants * immunocompromised patients * pateints with ventricular dysfunction and history of congestive heart failure
kin keepersm: reducing disparities through cancer literacy and screening

Conditions: Breast Cancer; Cervical Cancer

Summary: 1) to determine if the kin keepersm cancer prevention intervention increases first time and appropriately timed breast cancer screening rates among black, latina and arab women; 2) to determine if the kin keepersm cancer prevention intervention increase first time and appropriately time cervical cancer screening rates among black, latina and arab women; 3) to measure functional cancer literacy over time at the individual and familial level and 4) assess rates of healthcare utilization cost among women in the kin keepersm intervention and control-comparison groups.


Eligibility criteria:
inclusion criteria: * participants:self-identified as black latina and arab women ho can recruit at least two bloodline female family members (mother daughter sister, etc.; can accommodate two in-home visits by a community health worker; and 21-70 years of age. exclusion criteria: * are not self-identified as black, latina, or arab; do not have direct bloodline relatives; and are younger than 21 or older than 70 years of age.

Keywords: breast & cervical cancer prevention & screening
compassionate use of the incraft® aaa stent graft system

Conditions: Abdominal Aortic Aneurysm

Summary: to treat patients with abdominal aortic aneurysms requiring endovascular repair outside of the clinical protocol through compassionate use.

in the us, abdominal aortic aneurysms (aaa) are found in 4-8% of older men and 0.5-1.5% of older women, resulting in 30,000-40,000 elective procedures and 1,400 peri-operative deaths. the most significant complication of aaa is an aneurysm sac rupture from which more than 15,000 patients die annually and is the 15th leading cause of death in elderly between 60 to 85 years of age . in japan, it is estimated that approximately 14,000 endovascular aneurysm repair (evar) and open surgical repair cases were performed in the year 2010 . abdominal aortic aneurysms can be treated three ways: (1) medical management; (2) open surgical repair; and (3) endovascular aneurysm repair (evar). evar has emerged as an alternative treatment of aaa for most patients. it is less invasive than open repair and carries lower rates of early mortality and morbidity . it has also extended treatment options to patients who cannot undergo conventional surgical procedures due to a high operative risk. as evar technology evolves, it allows treatment of aaa with increasing complexity of the aortic neck and access vessels. the incraft ®aaa stent graft system is designed for endovascular repair of infrarenal aaas with complex aortic anatomies. this stent-graft system utilizes nitinol stent and polyester graft technology in an ultra-low profile delivery system, which assists the physician in deploying the device in a controlled, consistent, and precise manner within the aortic neck and iliac arteries. by isolating the aneurysmal sac, the system provides an alternative blood flow path to relieve pressure on the arterial vessel walls and minimize aneurysm growth and the potential for aneurysm sac rupture.

Eligibility criteria:
1. obtain an independent assessment by an uninvolved physician. 2. obtain informed consent from the patient or legal representative. the consent form used should provide information pertinent to the patient's specific situation. (if appropriate, the study consent form may be used with an addendum to inform the patient of concerns specific to their situation.) 3. obtain clearance from the institution in accordance with their policies. 4. notify the institutional review board and comply with their procedures.

Keywords: abdominal aortic aneurysm
text message treatment for social anxiety

Conditions: Social Anxiety

Summary: this is an intervention study designed to evaluate a text message based safety behavior fading treatment for people with social anxiety disorder.

this study hopes to assess whether a month long text message based safety behavior fading protocol is effective in reducing safety behaviors and social anxiety symptoms. over the course of four consecutive weeks, text messages will be sent to participants the first day of the study and every other day for four weeks (14 texts in total). these text messages will remind participants to either avoid using their three most engaged in safety behaviors (assessed at pre-treatment) or to stay present-focused. the past week frequency of the participants' safety behaviors will be assessed at the beginning of pre-treatment, post-treatment, and four week follow up assessments participants will be asked to complete an additional online questionnaire for both a post-treatment and a 4-week post-treatment follow up assessment. we hypothesize that: 1) the safety behavior group will show a greater overall reduction in social anxiety symptoms, 2) that the safety behavior group will show a reduction in the frequency of safety behavior use, and 3) that the present-focused group will show an increase in mindfulness.

Eligibility criteria:
inclusion criteria: * social phobia inventory score \> 29 exclusion criteria: * receiving therapy * changes in the past 4 weeks with medication for emotional difficulties * psychotic symptoms
metformin as adjuvant to insulin therapy in insulin-resistant diabetes mellitus with pregnancy

Conditions: Diabetes Mellitus

Summary: adding metformin to insulin therapy in pregnant women with diabetes mellitus who show insulin resistance may be equivalently effective to further raising the insulin dose


Eligibility criteria:
inclusion criteria: * pregnant women with insulin-resistant diabetes mellitus exclusion criteria: * type-1 diabetes mellitus * secondary diabetes mellitus

Keywords: diabetes mellitus pregnancy insulin metformin
systemic inflammation response index and c-reactive protein to albumin ratio in acute lymphoblastic leukemia

Conditions: Acute Lymphoblastic Leukemia

Summary: the goal of this observational study is assesment of systemic inflammatory index (sii) , system inflammation response index (siri) and crp albumin ratio(car) as biomarkers for all prognosis.

acute lymphoblastic leukemia (all) results from a clonal expansion of abnormal, immature lymphoid progenitors of b cell or t cell origin that invade bone marrow (bm), peripheral blood, and extramedullary sites . the incidence of all is highest among children aged 1-4 years and declines with age rising slightly after the age of 50. several genetic alterations have been already found as drivers of all, uncovering the genetic heterogeneity of the disease. it is the most common leukemia in the pediatric population, according for up to 80% of cases in this group vs. 20% of cases in adults. treatment among adolscents and young adults is predominantly inspired by pediatric regimens with better survival rates . acute leukemia tends to present non-specifically, although the most common presenting features include fever, lethargy, and bleeding. hepatosplenomegaly, lymphadenopathy, and musculoskeletal symptoms (especially involving the spine and long bones) can also be clues to the diagnosis. adults may also have more prominent anemia-related symptoms, such as shortness of breath, or symptoms related to thrombocytopenia, such as excessive bruising or increased bleeding tendency.

Eligibility criteria:
inclusion criteria: newly diagnosed all patients that admitted to the south egypt cancer institute and not received any treatment. exclusion criteria: 1. presence of other hematological disorders( other than all) 2. history of other malignancies, or relapsed all. 2- patients under chemotherapy or radiotherapy. 3- signs of inflammation 5- evidence of autoimmune disease.
brain diseases on 7.0t magnetic resonance imaging

Conditions: Brain Tumor; MRI; Cerebrovascular Disease

Summary: this clinical trial studies the use of 7-tesla (7t)and 3t magnetic resonance imaging (mri) in detecting brain diseases. 7t mri has increased detection sensitivity, including more accurate lesion delineation, higher inter-rater agreement. diagnostic procedures such as 7t mri may help ultimately improved diagnostic and therapies confidence to inform decision making than standard 3t mri.

7t mri increased detection sensitivity, attain superior anatomic resolution, higher spatial and spectral specificity of advanced quantitative techniques, and shorter scan times than 3t mri. when applied clinically, these benefits translate to increased detection sensitivity, and ultimately improved diagnostic and therapies confidence to inform decision making. this study aim to detect the image characteristics and diagnostic accuracy of brain diseases on 7t mri.

Eligibility criteria:
inclusion criteria: * age≥18 and ≤80 * having brain diseases (eg: brain tumor, cerebrovascular diseases) * having no contraindications against mri or intravenous contrast agent administration * clinically stable exclusion criteria: * age\ 80 * pregnancy and other contraindication to mri scan * informed consent not obtained

Keywords: brain tumor cerebrovascular disease mri ultra high field
defining remission with etanercept in as in real life clinical practice

Conditions: Ankylosing Spondylitis

Summary: determine which remission criterion at month 6 predicts remission at month 12 the best.

the analysis of the primary endpoint will be based on a logistic regression defining the dependent variable as the remission at month 12 and the 6 independent variables as asas partial remission, asas 5/6, asas60, asas40, basdai50 and asdas inactive disease status. this analysis will be conducted in each arm of the study as well as after a pooling of both patient groups. in this context it seems reasonable to ensure the completion of the study by a total approximate number of 100 patients (approximately 50 patients per arm). in order to ensure 50 completers in each arm, 70 patients will be recruited at baseline, taking into account a drop-out rate of 30% over 1 year period.

Eligibility criteria:
inclusion criteria: 1. patients with as who start treatment with etanercept according to prevailing reimbursement criteria and dosing in line with smpc. 1. first cohort: etanercept is the first biological product prescribed 2. second cohort: etanercept is the second biological product prescribed 2. capable of understanding and willing to provide signed and dated written, voluntary informed consent before any protocol-specific procedures are performed. 3. 18 years of age or older at time of consent 4. evidence of a personally signed and dated informed consent document indicating that the patient (or a legally acceptable representative) has been informed of all pertinent aspects of the study. exclusion criteria: 1. history of or current psychiatric illness that would interfere with the subject's ability to comply with protocol requirements or to give informed consent.
use of melatonin for preventing pocd in transurethral prostate resection under spinal anesthesia

Conditions: Melatonin; Cognitive Dysfunction; Postoperative Complications; Prostate Hyperplasia

Summary: this study aims to evaluate the possible effect of melatonin on prevention of cognitive dysfunction in the postoperative period of elderly patients undergoing transurethral resection of the prostate (turp) under spinal anesthesia

turp is the most common surgical procedure performed on male patients over 60 years of age to treat benign prostatic hyperplasia. one of the concerns, since it compromises the quality of life, is postoperative cognitive dysfunction. it can be due to turp syndrome or to other causes, like changing the routine and circadian rhythm for patients with more susceptibility. the investigators postulate that melatonin premedication and use during the perioperative period could avoid cognitive impairment in patients undergoing turp surgery that didn't develop major complications, like turp syndrome. since anesthestic technic could also influence the outcome of pocd, only patients undergoing spinal anesthesia were included in the study,

Eligibility criteria:
inclusion criteria: patients over 60 years who underwent elective surgery for transurethral prostate ressection under spinal anesthesia. mme \> 18 (for those who had less than 4 years of formal education ) or mme \> 23 (for those with 4 or more years of formal education) exclusion criteria: mme \< 18 (for those who had less than 4 years of formal eduaction) or 23 (for those with 4 years or more of formal eduacation); history of cancer, brain disease, seizure, parkinson, dementia, hallucination or any disorder that affects cognition before the surgery. lack of proficiency in portuguese mild or severe hearing loss or blindness.

Keywords: melatonin cognitive dysfunction
an open-label extension trial of cannabidiol (gwp42003-p, cbd) for seizures in tuberous sclerosis complex (gwpcare6)

Conditions: Tuberous Sclerosis Complex; Seizures

Summary: this trial consists of 2 parts: a double-blinded phase and an open-label extension phase. the open-label extension phase only will be described in this record. all participants will receive the same dose of gwp42003-p. however, investigators may subsequently decrease or increase the participant's dose until the optimal dose is found.


Eligibility criteria:
key inclusion criteria: * completion of the gwep1521 blinded phase
pelvic floor muscle training in treating urinary incontinence in gynecologic cancer survivors

Conditions: Cervical Cancer; Endometrial Cancer; Ovarian Epithelial Cancer; Ovarian Germ Cell Tumor; Uterine Sarcoma; Vulvar Cancer

Summary: this randomized pilot clinical trial studies pelvic floor muscle training in treating urinary incontinence in gynecologic cancer survivors. pelvic floor muscle training may help control symptoms and improve physical function and quality of life in gynecologic cancer survivors.

primary objectives: i. to assess whether pelvic floor muscle training and behavioral therapy in gynecologic cancer survivors results in improvement in incontinence symptoms as measured by a validated questionnaire (patient global impression of improvement) at three month follow-up when compared to women who do not undergo pelvic floor muscle training. ii. to evaluate whether women who undergo pelvic floor muscle training and behavioral therapy report greater improvement in validated urinary incontinence symptom severity, pelvic floor distress and quality of life measures than women who do not undergo pelvic floor muscle training. iii. to evaluate the acceptability of pelvic floor muscle training (pfmt) among gynecological cancer survivors and to provide preliminary data to inform a power analysis for a larger randomized trial. outline: patients are randomized to 1 of 2 treatment arms. arm i: patients receive a handout describing behavioral management tips for urinary incontinence, including information and suggestions about optimal volume fluid intake, constipation management, measures to reduce urgency by spreading fluid intake, and avoiding caffeine and other bladder irritants that have proved effective in other intervention trials. patients undergo pfmt over 20-30 minutes teaching them to contract the pelvic floor muscles correctly and receive feedback to avoid the contraction of abdominal, gluteal or adductor muscles. patients are asked to perform 3 sets of 10 pelvic muscle contractions with a goal of holding the contraction for 5 seconds daily for 12 weeks and also receive a reminder phone call to address concerns and review the instructions at 4 weeks. arm ii: patients receive usual care for urinary incontinence, with an option to join the training program after completion of study. after completion of study treatment, patients are followed up at 3 months.

Eligibility criteria:
inclusion criteria: * history of uterine, cervical, ovarian or vulvar malignancy * treatment free interval of \>= one year and currently have no evidence of cancer * reports urinary incontinence based on screening questionnaire * must have a stable address for the three month period exclusion criteria: * current clinical evidence of urinary tract infection * within three months of failed surgery for urinary incontinence * planned surgery for urinary incontinence in the next three months * presence of neurologic condition that may impact bladder symptoms such as multiple sclerosis, stroke * pregnancy

Keywords: pelvic floor muscle training; incontinence; quality of life
rhbmp-2 in intrabony defects - a randomized controlled trial

Conditions: Periodontitis

Summary: this study evaluated the regenerative potential of rhbmp-2 gel in intrabony defects when compared to sticky bone (control).

it was done in 40 subjects who were evaluated for a period of 6 months. the results were evaluated clinically (cal, ppd) and radiographically (bone fill) and after 6 months.

Eligibility criteria:
inclusion criteria: * systemically healthy male and female patients age 20-55 years with intrabony defects and probing pocket depth of ≥5mm after initial therapy were included in the study. exclusion criteria: * medically compromised patients, subjects who underwent radiotherapy or chemotherapy and smokers were excluded.

Keywords: sticky bone intrabony defects regeneration
stability of the knee joint after single and double bundle anterior cruciate ligament reconstruction

Conditions: Rupture of Anterior Cruciate Ligament

Summary: the purpose of this prospective study is to evaluate the influence of both bundles on the knee stability - anterior-posterior translation, internal and external rotations after the double-bundle reconstruction of anterior cruciate ligament and to compare the stability after single-bundle and double-bundle reconstruction using a computer navigation system.

the purpose of this prospective study is to evaluate the influence of both bundles on the knee stability - anterior-posterior translation, internal and external rotations after the double-bundle reconstruction of anterior cruciate ligament (acl) and to compare the stability after single-bundle and double-bundle reconstruction using a computer navigation system. methods anterior-posterior translation, internal rotation, and external rotation were recorded in the deficient condition (without acl), in the anteromedial-reconstructed, posterolateral-reconstructed, and in the whole acl-reconstructed condition for double-bundle reconstructions and before and after the acl reconstruction in single-bundle group. kt-1000 was used to evaluate anterior-posterior translation.

Eligibility criteria:
inclusion criteria: * isolated acl lesion and primary acl replacement exclusion criteria: * replacement of acl with navigation system

Keywords: acl double-bundle navigation system