Kornimate/medical-research-clean huggingface dataset:
the influence of reducing diets on changes in thyroid parameters in obese women with hashimoto's disease

Conditions: Hashimoto Disease; Obesity

Summary: hashimoto's disease is listed among the most common endocrine causes of obesity. as treatment of obesity in women with hashimoto's disease is frequently unsuccessful, the aim of this study was to evaluate the effectiveness of two different reducing diets and their influence on changes in thyroid parameters in the female patients. a six-month observational/interventional study was performed on 100 women aged 18-65 years, previously diagnosed with hashimoto's disease and obesity and receiving l-thyroxine. the women were randomly assigned to the test group (group a, n=50) following elimination/reducing diets, and the control group (group b, n=50) following reducing diets with the same caloric content (without elimination). anthropometric and thyroid parameters were evaluated at the beginning, after 3 months and after 6 months of treatment.


Eligibility criteria:
inclusion criteria: * diagnosed with hashimoto's disease * bmi over 30 kg/m2 * taking the l-thyroxine, 200 mcg of 1-selenomethionine/day, and 30 mg of zinc gluconate/day throughout the study period exclusion criteria: ---

Keywords: hashimoto obesity elimination diet thyroid gland adults
evaluation of pilot online binge eating disorder group (beg) in under 18s.

Conditions: Binge Eating Disorder

Summary: the national institute for clinical excellence recommends a cognitive behavioural therapy (cbt) group intervention for binge eating disorder in under-18s. however, there is limited current research in this population. the present study sought to evaluate a cbt group intervention for binge eating disorder in under-18s.

background and study aims: the national institute for clinical excellence recommends a cognitive behavioural therapy (cbt) group intervention for binge eating disorder in under-18s. however, there is limited current research in this population. the present study sought to evaluate a cbt group intervention for binge eating disorder in under-18s. who can participate? participants were recruited from the coventry warwickshire partnership trust's children and young people eating disorders team (n=2). what does the study involve: participating in a group intervention and completing questionnaires (eating disorder examination - questionnaire (ede-q), revised children's anxiety and depression scale (rcads) child and rcads parent) before the group, at the end of the group and a follow-up appointment, as well as a feedback form at the end of the group intervention. what are the possible benefits and risks of participating: * benefits: working towards recovering from binge eating disorder * risks: as with all therapy, there is a risk of distress due to the topics discussed. there is no more risk than any other group online therapy. where is the study run from: online intervention for participants who are eligible and who are under the care of the rise eating disorders team within coventry and warwickshire nhs partnership trust. when is the study starting and how long is it expected to run for: the study commenced on on 23rd may 2023. the group intervention ran from 20th june 2023 to 26th september 2023.

Eligibility criteria:
inclusion criteria: * diagnosed with binge eating disorder * under 18 prior to the group commencing * spoke english fluently exclusion criteria: * if they were underweight. this was measured by percentage median body mass index (%mbmi) as recommended by the medical emergencies in eating disorders guidelines (royal college of psychiatrists, 2022) for under 18s. as such, individuals were excluded if %mbmi was less than 95% * if they had any physical illness serious enough to prevent the participant from engaging fully in the group and completing the in-between session work * if they were pregnant * if they had an eating disorder-induced physical health state requiring regular medical intervention by the nursing team * if they presented a mental health state requiring stabilisation prior to participating in the group intervention according the assessment team * if they regularly used alcohol and/or drugs * if they repeatedly self-harmed to the point of requiring additional interventions * if they had a living situation not conducive to the start of an intervention (ongoing or upcoming changes).

Keywords: group adolescent
efficacy and safety of lanthanum carbonate in reducing serum phosphorus levels in subjects with stage 3 and 4 chronic kidney disease

Conditions: Kidney Diseases

Summary: chronic kidney disease (ckd) can result in a loss of ability to filter and excrete phosphate. the body's attempt to adjust to an increased level of phosphate in the blood can result in elevated levels of hormones and minerals resulting in serious clinical consequences. this study is being conducted to evaluate the safety and efficacy of lanthanum carbonate in lowering high levels of phosphorus in the blood in subjects with ckd stages 3 and 4 compared to placebo.


Eligibility criteria:
inclusion criteria: * under a physician's care for ckd for \> 2 months and are not expected to begin dialysis for 4 months * screening estimated gfr of 15-59 ml/1.73 m2 * serum phosphorus \>= 4.7 mg/d following washout exclusion criteria: * requiring treatment with cinacalcet hci or compounds containing phosphate, aluminum, calcium or magnesium * rapidly progressing glomerulonephritis * cirrhosis or other clinically significant liver diseases * past or present uncontrolled peptic ulcer, crohn's disease, malignancy or recent gi bleed
the relationship between drainage fluid and anastomotic leakage after colorectal cancer surgery

Conditions: Anastomotic Leakage

Summary: a prospective and analytical study on the detection of early anastomotic leakage by abdominal drainage fluid after colorectal cancer surgery. pay attention to indicators including bilirubin


Eligibility criteria:
inclusion criteria: 1) preoperative pathologically confirmed colorectal adenocarcinoma; 2) patients undergoing minimally invasive (robot or laparoscopic) tumor resection + bowel anastomosis; 3) age: 18 to 80 years old; 4) preoperative tnm staging (whole abdomen) enhanced ct or mri, laparoscopic exploration): ct1-3bn0-2m0; 5) preoperative asa score: ≤ⅲ; 6) no history of malignant tumors and no other malignant tumors by preoperative examination; 7) not accepted before surgery deterministic treatment, such as radiotherapy, chemotherapy or immunotherapy; 8) no pre-existing ascites was found before and during the operation; 9) informed consent signed by the patient or his agent performance status (ecog) 0\~1 exclusion criteria: 1) patients with obstructive jaundice or other congenital disorders of bile acid synthesis and metabolism; 2) severe abdominal cavity infection and other infections; 3) a large amount of abdominal effusion was found before and during the operation; 4) tumor was confirmed during the operation for t4b or intraoperative detection of other tumors, joint resection or distant metastasis is required; 5) intraoperative conversion to laparotomy; 6) intraoperative change of surgical method to perform miles or hartmann surgery; 7) intraoperative and postoperative abdominal cavity hyperthermic perfusion chemotherapy.
advanced pelvic surgical oncology database - prospective observational study

Conditions: Rectal Cancer; Pelvic Cancer; Gynecologic Cancer; Colon Cancer

Summary: retrospective and prospective observational study of patients undergoing advanced pelvic oncological resection for maligancy including multi visceral resection, beyond tme resection and sacrectomy/flap reconstruction/urinary reconstruction at glasgow royal infirmary. goal is to study and report outcomes for patients to characterise and understand major complications, natural history of resectional patients and identify areas for future interventional study.

retrospective and prospective observational study of patients undergoing advanced pelvic oncological resection for maligancy including multi visceral resection, beyond tme resection and sacrectomy/flap reconstruction/urinary reconstruction at glasgow royal infirmary. goal is to study and report outcomes for patients to characterise and understand major complications, natural history of resectional patients and identify areas for future interventional study..

Eligibility criteria:
inclusion criteria: * advanced pelvic oncological resection defined as more than 1 pelvic organ resected exclusion criteria: -

Keywords: pelvic exenteration abdominoperineal resection reconstructive flap rectal cancer
new imaging procedures and therapeutic approach in basal cell carcinoma management

Conditions: Basal Cell Carcinoma

Summary: the aim of this study is to show that the nd:yag laser could be a promising alternative treatment option in the management of low-risk basal cell carcinomas with similar high efficacy rates to surgery, and low recurrence rates evaluated over a time period of one year. reflectance confocal microscopy, optical coherence tomography and clinical examination are used prior to confirm the clinical diagnosis of the basal cell carcinoma and for premargination of the tumor. the optical coherence tomography will also be used post treatment to confirm clearance of the basal cell carcinoma and to monitor treatment response.


Eligibility criteria:
inclusion criteria: patients with one or more basal cell carcinoma(s) on head, trunk or extremities * diagnosed clinically, with a dermatoscope and through noninvasive imaging methods such as reflectance confocal microscopy and optical coherence tomography * h zone \<6mm, m zone \<10mm, l zone \<20mm * tumor thickness \<2mm * clearly visible margins exclusion criteria: * pregnancy * \<18 years of age * current or history of immunosuppression * prior-treatment of the basal cell carcinoma/ recurrent basal cell carcinomas * history of radiation in the area of basal cell carcinoma appearance
expression of altered glycosyltransferases, mucins, and rtks in human ovarian and endometrial cancers

Conditions: Carcinogenesis; Ovarian Cancer; Endometrial Cancer

Summary: to clarify the critical role of glycosyltransferases, altered mucins, and rtks in human ovarian and endometrial neoplasms, the study will examine the immunohistochemical expression profiles of glycosyltransferases, mucins and receptor tyrosin kinases (rtks) family in various stages and/or histologic subtypes of human ovarian and endometrial neoplasms and tissue microarrays.

glycosylation is a widely utilized chemical modification of proteins and lipids in mammalian cells during which saccharide units are covalently attached to the target structures and then sequentially elongated and branched - reactions facilitated by a large number of various glycosyltransferases. alterations in this process have been associated with malignant transformation. to clarify the critical role of glycosyltransferases, altered mucins (muc), and rtks in human ovarian and endometrial neoplasms, the study will examine the immunohistochemical expression profiles of glycosyltransferases (including β-1,4-galactosyltransferase 1 (b4galt1), β-1,4-galactosyltransferase 3 (b4galt3), β-1,4-n-acetyl-galactosaminyl transferase 3 (b4galnt3), polypeptide n-acetylgalactosaminyltransferase 2 (galnt2), polypeptide n-acetylgalactosaminyltransferase 6 (galnt6), β1,4-n-acetylglucosaminyltransferase iii (glcnact-iii), β1,4-n-acetylglucosaminyltransferase v (glcnact-v), and glycoprotein-n-acetylgalactosamine 3-beta-galactosyltransferase 1 (c1galt1), mucins (including muc1, muc3, muc15, and muc20) and receptor tyrosin kinases (rtks) family (including epidermal growth factor receptor (egfr), src, vegfr, and c-met) in various stages and/or histologic subtypes of human ovarian and endometrial neoplasms and tissue microarrays, and compare them with clinicopathologic factors including outcome of the patients.

Eligibility criteria:
inclusion criteria: * ovarian and endometrial cancer patients receiving operation in national taiwan university hospital exclusion criteria: * recurrence or non-operable patients

Keywords: glycosylation mucin receptor tyrosin kinases ovarian cancer endometrial cancer
a study with ro5095932 in patients with type 2 diabetes on stable metformin therapy.

Conditions: Diabetes Mellitus Type 2

Summary: this randomized, double-blind, placebo-controlled study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of ro5095932 in adult patients with type 2 diabetes mellitus. patients that are on stable metformin therapy are eligible to enter the study. there will be a 5-weeks exenatide run in period and a 5-weeks period when co-administered with the study drug. ro5095932 will be administered subcutaneously as a single dose or as escalating doses. patients will be randomized to receive either active drug or placebo in weeks 1 to 4. active drug or placebo will be administered once weekly for 4 weeks. patients who received active drug in weeks 1 to 4 will receive placebo in week 5. patients who received a single dose of placebo in weeks 1 to 4, will receive a single dose of active drug in week 5. the anticipated time of study treatment is \<6 months. the target sample size is \<100 patients.


Eligibility criteria:
inclusion criteria: * adult patients, 18-65 years of age * diabetes mellitus, type 2 for at least 6 months before screening * on treatment with stable doses of metformin for at least 3 months before screening * bmi between \>/=25 and \</=39 exclusion criteria: * type 1 diabetes * pancreatitis * treatment with insulin for more than one week within 3 months prior to study start
a multi-level approach to heat-related illness prevention in agricultural workers

Conditions: Heat Stress Disorders

Summary: the project's primary aim is to evaluate the effectiveness of a multi-level heat prevention approach in reducing adverse heat health effects in outdoor agricultural workers the secondary aims are to: * test the effectiveness of an individual-level training component designed to reduce adverse heat health effects in outdoor agricultural workers * evaluate the effectiveness of a workplace supervisor-level heat awareness application intended to support supervisor decisions to reduce the risk of workers experiencing adverse heat health effects


Eligibility criteria:
inclusion criteria: * speak english or spanish, live in same dwelling and work at same farm for the season, farm where participant works must agree to collaborate exclusion criteria:
odevixibat pregnancy and lactation surveillance program: a study to evaluate the safety of odevixibat during pregnancy and/or lactation

Conditions: Pregnancy Related

Summary: the participants of this study will be of any age who are exposed to at least 1 dose of odevixibat at any time during pregnancy (from 1 day prior to conception to pregnancy outcome) and/or at any time during lactation (up to 12 months of infant age or weaning, whichever comes first. this study will collect data obtained via a variety of sources, including enrolled pregnant or lactating participants, the healthcare providers (hcp) involved in their care or the care of their infants, if applicable, and albireo pharmacovigilance. study start date is either start of data collection or first patient enrolled whatever occurs earlier. the surveillance program is strictly observational; the schedule of office visits and all treatment regimens are determined by hcps. only data that are routinely documented in patients' medical records as part of usual care will be collected. no additional laboratory tests or hcp assessments will be required as part of this surveillance program.


Eligibility criteria:
inclusion criteria: * exposure to at least 1 dose of odevixibat at any time during pregnancy (from 1 day prior to conception to pregnancy outcome) and/or at any time during lactation (up to 12 months of infant age or weaning, whichever comes first). * informed consent or irb-/ec-approved waiver of informed consent (not applicable if reported by albireo pv according to usual pharmacovigilance practices) exclusion criteria: * refusal to provide informed consent, if required

Keywords: rare disease pfic pregnancy lactation
open-label study of bbo-8520 in adult subjects with krasg12c non-small cell lung cancer

Conditions: Non-small Cell Lung Cancer; Metastatic Non-Small Cell Lung Cancer; NSCLC; KRAS G12C; Metastatic Lung Cancer; Advanced Lung Carcinoma

Summary: a first in human study to evaluate the safety and preliminary antitumor activity of bbo-8520, a kras g12c (on and off) inhibitor, as a single agent and in combination with pembrolizumab in subjects with locally advanced and unresectable or metastatic non-small cell lung cancer with a kras (kirsten rat sarcoma) g12c mutation.

this is an open-label, multi-center, phase 1 study designed to evaluate the safety, tolerability, pharmacokinetics, and efficacy of bbo-8520, a direct inhibitor of krasg12c (on and off), alone and in combination with the ici pembrolizumab in subjects with locally advanced and unresectable or metastatic non-small cell lung cancer with a kras (kirsten rat sarcoma) g12c mutation. the study includes dose escalation phase and dose expansion phase

Eligibility criteria:
inclusion criteria: * histologically documented locally advanced and unresectable or metastatic non-small cell lung cancer with a kras g12c mutation * measurable disease by recist v1.1 * eastern cooperative oncology group (ecog) performance status (ps) 0-1 exclusion criteria: * patients with malignancy within the last 2 years as specified in the protocol * patients with untreated brain metastases * patients with known hypersensitivity to bbo-8520 or its excipients * for cohorts 1b and 2b: * patients with a known hypersensitivity to pembrolizumab or its excipients * patients with active autoimmune disease of history of autoimmune disease that might recur * patients with a history of interstitial lung disease/pneumonitis that required steroids, or current interstitial lung disease/pneumonitis other inclusion/exclusion criteria may apply
the asian pacific tavr multicenter registry

Conditions: Aortic Valve Stenosis

Summary: the purpose of this study is to evaluate the clinical outcomes of transcatheter aortic valve replacement (tavr) in the asian pacific population


Eligibility criteria:
inclusion criteria: * patients with symptomatic severe aortic stenosis who are not candidates for surgical aortic valve replacement because of coexisting illnesses. * the patient or guardian agrees to the study protocol and the schedule of clinical follow-up, and provides informed, written consent, as approved by the appropriate institutional review board/ethics committee of the respective clinical site.

Keywords: transcatheter aortic valve replacement
combination of cryosurgery and nk immunotherapy for advanced liver cancer

Conditions: Secondary Malignant Neoplasm of Liver

Summary: the aim of this study is the safety and efficacy of cryosurgery plus nk immunotherapy to advanced liver cancer.

by enrolling patients with liver cancer adapted to enrolled criteria, this study will document for the first time the safety and the short and long term efficacy of the combined therapy using cryosurgery and nature killer (nk) cells for advanced liver cancer. the safety will be evaluated by statistics of adverse reactions. the efficacy will be evaluated according to local relief degree, progress free survival (pfs) and overall survival (os).

Eligibility criteria:
inclusion criteria: * all standard therapies have failed according to nccn guidelines or the patient refuses standard therapies after cancer recurrence * body tumor 1-6, the maximum tumor length \< 5 cm * kps ≥ 70, lifespan \> 6 months * platelet count ≥ 80×109/l，white blood cell count ≥ 3×109/l, neutrophil count ≥ 2×109/l, hemoglobin ≥ 80 g/l exclusion criteria: * patients with cardiac pacemaker * patients with brain metastasis * patients with grade 3 hypertension or diabetic complication, severe cardiac and pulmonary dysfunction

Keywords: metastatic liver cancer cryosurgery nk immunotherapy
the influence of coronally knee alignment on the tibial tuberosity rotation

Conditions: Knee Osteoarthritis

Summary: the primary aim of this study is to find a possible correlation between tibial tuberosity rotation and coronal leg alignment. if correlation exists, a more individual tibial component rotation might be proposed during a total knee arthroplasty.

a malalignment of the tibial component is a possible source of pain after a total knee arthroplasty. currently, an internal rotation of the tibial component of 18 degrees is considered as a golden standard. the value was obtained as an average rotation in the osteoarthritic knees scheduled for a total knee arthroplasty. it is known that the femur internally rotates with the increasing valgus alignment. it would seem logical that also tibial rotation correlates with the coronal limb alignment (varus-valgus). the plan is to measure the native tibial rotation (angle between the transposed epicondylar line and the posterior cruciate-tibial tuberosity line). in order to get the necessary accuracy a ct of lower legs will be obtained in patients waiting for the knee replacement. if there is a correlation between the angles the adjustment of the tibial component rotation more to the patient's anatomy could be proposed. a secondary outcome measure is the possible correlation between the proximal femoral anteversion and the tibial tuberosity rotation. the hypothesis is that the extensor mechanism follows the proximal femoral orientation. with increasing femoral anteversion (increases with valgus angle) the femoral part of the knee rotates internally. in order to keep the extensor mechanism in the direction of walking, a more lateralized position of the tibial tuberosity is expected.

Eligibility criteria:
inclusion criteria: * patients requiring knee arthroplasty exclusion criteria: * women in reproductive age, patients with leg deformities and previous hip/knee surgery

Keywords: knee alignment knee arthroplasty tibial component rotation