Kornimate/medical-research-clean huggingface dataset:
a practice-nurse addressed intervention to improve type 2 diabetes care

Conditions: Type 2 Diabetes

Summary: a huge challenge in type 2-diabetes care is how to motivate patients towards health behaviour changes. in denmark, the tendency is that nurses in general practice provide a large part of type 2 diabetes care. observational studies support self-determination theory by finding autonomous motivation and perceived competence associated with improved hba1c-levels in patients with type 2 diabetes. hence, research is needed to develop and test interventions that are autonomy supportive. aim to develop a training course for practice-nurses in autonomy support in patients with type 2 diabetes, and to evaluate the effect on patient outcomes. methods the development of the intervention was based on literature research and expert meetings. the intervention is evaluated in a cluster randomised controlled trial with 40 danish general practices, * where nurses, before enrolment in the study, provided consultations to patients with type 2 diabetes, * and about 2500 patients with type 2 diabetes, identified in a diabetes database. the patients will be followed 15 months from nurse-participation in the course. data will be obtained from registers and patient-questionnaires. the hypothesis is that patients with type 2 diabetes regardless of education level, age, and gender will benefit from the intervention.


Eligibility criteria:
inclusion criteria: * the intervention-study comprises 40 general practices were: 1. more than 50% of the patients with type 2 diabetes, who had participated in diabetes-consultations during the last year from the invitation-date to the project, were seen by a nurse at least once, stated by the practice. the diabetes-consultation should not only include examinations (blood tests and blood pressure measurement), but should also include communication about living with type 2 diabetes ; 2. enrollment in the project before registration deadline (three weeks after invitation). patients with diabetes, alive and affiliated the practices by may 2011, were identified in a a validated diabetes database based on health registers; the national patient registry, the national health insurance service registry, the prescription database and the laboratory database in the county.

Keywords: motivation patients with type 2 diabetes practice nurses general practice self-determination theory
the efficacy of five anthelmintic regimes against trichuris trichiura infections in schoolchildren in jimma, ethiopia

Conditions: Infection by Trichuris Trichiura

Summary: the major soil-transmitted helminths (sths), ascaris lumbricoides (roundworm), trichuris trichiura (whipworm) and necator americanus/ancylostoma duodenal (hookworms) are amongst the most prevalent parasites worldwide. an estimated 4.5 billion individuals are at risk for sth and more than one billion individuals are thought to be infected, of which 450 million have significant morbidity attributable from their infection, school-aged children in particular. in this population infections cause stunting of the linear growth, anemia, reduce the cognitive function and contribute to the existing malnutrition. in jimma (ethiopia), sth are highly prevalent, affecting more than 60% of the children (data not published). current efforts to control sth infections involve periodic mass drug anthelmintic treatment of infected children in endemic areas and are likely to intensify as more attention is addressed to the importance of these neglected diseases. monitoring drug efficacy in these control programs has become indispensable in order to detect the emergence of resistance and/or identify confounding factors affecting the drug efficacy. recently a study has evaluated a single dose albendazole (alb) in school age children across 7 countries, including ethiopia, revealing that this regime is highly efficacious for the treatment of a. lumbricoides (99.5%) and hookworms (94.8%), but not for t. trichiura (50.8%). for this parasite a repeated dose regime of alb on consecutive days is likely to be more appropriate. alternative drugs are mebendazole (single dose 500mg) and pyrantel+oxantel (single dose 10mg/kg), of which the latter holds promise as it can also be administrated to children between 6 months and 2 years. the main objective of the present study, therefore, is to assess the efficacy of 5 different treatment regimes against t. trichiura in schoolchildren in jimma, ethiopia, including albendazole (1 x 400mg, 2 x 400mg), mebendazole (1 x 500mg, 2x 500mg) and pyrantel-oxantel (10mg/kg)+mebendazole (500mg).


Eligibility criteria:
inclusion criteria: * all school age children who are eligible to participate in the study exclusion criteria: * not willing to participate (no informed consent) * unable to give samples for follow up * severe intercurrent medical condition * diarrhea at first sampling * study subjects who had treatment for sth in the last 3 months
capsaicin to prevent delayed chemotherapy induced nausea and vomiting (capcin)

Conditions: Chemotherapy-induced Nausea and Vomiting

Summary: chemotherapy-induced nausea and vomiting (cinv) is one of the few most severe adverse effects of chemotherapy, which often panic patients undergoing cancer treatment. though acute episodes of cinv are well controlled with pharmacologic agents, delayed cinv continues to present a treatment challenge. significant progress has been made over the past many years in discovering the pathophysiology of cinv. primarily, three areas in the brain including central pattern generator (cpg), nucleus tractus solitarius (nts) and area postrema (ap) are implicated in generating emetic reflex in all types of cinv (anticipatory, acute and delayed). the latter two areas nts and ap are located at the caudal end of the fourth ventricle of brain which lies outside of the blood brain barrier and hence are stimulated by agents present in either blood and/or cerebrospinal fluid (csf). furthermore, nts and ap are rich in muscarinic, dopamine, serotonin, neurokinin (nk1) and histamine receptors which are particularly important in delayed cinv. clinical trials of antimuscarinic, antidopaminergic, antihistaminic drugs to prevent cinv have yielded inconclusive results except for olanzapine which is known to act on multiple receptors in nts/ap. only nk1 antagonists (e.g. aprepitant) which prevent substance p (sp) from binding to nk1 receptors have shown promising results and are clinically used to prevent delayed cinv. sp is a tachykinin peptide encoded by tac1 (tachykinin precursor 1) gene and is found abundant in both peripheral and cns. nk1 receptors in nts/ap upon binding with sp will generate emetic reflex which will trigger delayed cinv. though the topical analgesic drug capsaicin is reported to interfere with endogenous sp, its antiemetic potential in cinv has not been studied. this study intend to explore the antiemetic potential of capsaicin which is known to interfere with sp release in the git and cns.


Eligibility criteria:
inclusion criteria: 1. adult chemotherapy naïve patients of at least 18 years old 2. diagnosed with a malignant disease and scheduled for highly emetogenic chemotherapy (as defined by nccn guidelines v1.2019) 3. no concurrent radiotherapy or use of other antiemetic drugs except (dexamethasone, ondansetron/granisetron, and olanzapine) 4. normal renal and hepatic function exclusion criteria: 1. pregnant or breast feeding 2. contraindication for capsaicin or other medications in the study 3. has ongoing nausea and/or vomiting of other etiology 4. history of anticipatory nausea and/or vomiting or has vomited/nauseated within 24 hours prior to the start of scheduled chemotherapy 5. chronic alcoholism

Keywords: chemotherapy capsaicin nausea and vomiting
postoperative sleep disturbances role in cognitive test results after fast-track hip and knee arthroplasty

Conditions: Postoperative Cognitive Abilities

Summary: the purpose of this study is to evaluate sleep cycle before and after fast-track arthroplasty (3 days before and 10 days after) combined with cognitive testing preoperatively, on postoperative day 1,2,10.


Eligibility criteria:
inclusion criteria: * above 60 * asa classification i-iv exclusion criteria: * general anaesthesia within 90 days * daily use of sedatives, hypnotics og anxiolytics * alcohol abuse * insufficient written and verbal danish * severe hearing loss and poor sight * parkinsons disease or other functional neurological deficits * mini mental status \< 24 * shift work
music therapy during hypothermia in the nicu

Conditions: Music Therapy; Pain; Allodynia; Neonates; NICU; Hypothermia Neonatal

Summary: background: hypoxic-ischemic encephalopathy (hie) is a neurological condition caused by poor oxygenation during the peripartum period. the main strategy to mitigate neurological damage is hypothermic therapy (ht), whose effectiveness-among other factors-depends on adequate pain management. considering the prevalence of allodynia in this group of patients, routine nursing procedures can become sources of additional stress and pain. music therapy is used in this population to promote self-regulation and relaxation, and may therefore help reduce pain levels after routine nursing procedures. research question: what is the effect of an entrainment-based live music therapy intervention on pain levels in newborns with hypoxic-ischemic encephalopathy undergoing hypothermic therapy after routine nursing procedures? methodology: a randomized, crossover pilot and feasibility study. participants will be 22 newborns admitted to the neonatal intensive care unit (nicu) of the university hospital fundación santa fe de bogotá. participants will receive standard care plus a 15-minute live music therapy session after a routine nursing procedure, or standard care alone. the primary outcome is the premature infant pain profile-revised (pipp-r) scale, which will be assessed through video recordings. secondary outcomes are vital signs, heart rate variability, and electroencephalography (eeg) recordings. expected outcomes: through this study, the aim is to improve the comfort and well-being of patients with hie during th. in addition, the safety and feasibility of music therapy in this population will be evaluated, seeking to contribute to current knowledge about the mechanisms of music therapy.


Eligibility criteria:
inclusion criteria: - neonates diagnosed with neonatal hypoxic ischemic encephalopathy who have undergone hypothermic therapy as part of their medical treatment. exclusion criteria: * newborns with a gestational age of less than 35 weeks and a birth weight of less than 1800 grams. * newborns in palliative care or with congenital anomalies with a poor prognosis will also be excluded, as will those with preexisting neurological or genetic conditions. * furthermore, newborns with a history of serious medical complications that may influence participation in the study, such as pulmonary hypertension or secondary seizure syndrome, will be considered ineligible. * finally, patients with an n-pass score of less than -2 will be excluded.
reliability and feasibility of weefim instrument to measure functional independence in pediatric burns

Conditions: Burns

Summary: purpose: is to test the feasibility and the reliability of the arabic version of wee functional independence measure (weefim) in children with healed burns. background: since kids are the most influenced casualty of burn and they may have lasting disabilities because of this harm, consequently they should have care in evaluation and treatment procedure in exploration. there are two main instruments that can be utilized to evaluate the function of young kid's which are the functional independence measure for kids (weefim) instrument and the pediatric evaluation of disability inventory (pedi) instrument. therefore, the aim of this study was to investigate the reliability and feasibility of the arabic version of the weefim instrument in kids from 3 years to 16 years of age with healed burn. hypotheses: arabic version of weefim questionnaire will not be feasible and reliable to measure and report the functional outcome of kids with healed burns. research question: is the arabic version of weefim instrument feasible and reliable enough to measure and report the functional outcome of children with healed burns?

1. first the weefim will undergo forward arabic translation followed by english backward translation. 2. second the instrument will be adapted to egyptian accent. 3. third the process of filling of questionnaire will be applied. it will be either parent filled or child filled. and will be performed by interview for illiterate patients. 4. last, statistical analysis for feasibility and reliability will be performed.

Eligibility criteria:
inclusion criteria: * patients who had a healed burn with an age from 3 years to 16 years. * all participants or their parents had to be able to read, write, and speak arabic * they had passed two weeks post-burn. exclusion criteria: * children with a history of neurological impairment or orthopedic surgery to the limbs or spine. * those with severe burns (4th degree burns), extensive burn is \>60%. * infected burn wounds. * other medical conditions that might impair physical performance. * children with any medical illness present in the previous month.

Keywords: weefim instrument functional independence pediatric burns
study on the quantitative assessment of the risk of hepatocellular carcinoma in patients with chronic liver disease using multi-parameter magnetic resonance imaging

Conditions: Cirrhosis； Tumor

Summary: quantitative mri scanning parameters such as t1 mapping, t2 mapping, t1ρ, and elastography are used, combined with clinical and laboratory indicators, to predict the risk of liver cancer in patients with cirrhosis.

retrospectively and prospectively collect t1 mapping, t2 mapping, t2\* mapping, t1ρ, elastography and other multi-parameter mri sequence images and clinical and laboratory examination data from patients with liver cirrhosis, and conduct 5-year clinical follow-up and monitoring of all enrolled patients. whether patients develop hepatocellular carcinoma, patients are divided into liver cancer occurrence group and non-hepatocellular carcinoma group according to clinical follow-up results. cox proportional hazard analysis is used to compare the differences in clinical characteristics, laboratory tests, imaging characteristics, quantitative mri parameters and other variables between the two groups of patients. , and calculate the hazard ratio for each variable; assign a score to each covariate based on the proportion of the hazard ratio in the multivariable model, and develop a nomogram to predict hcc risk by the total score.

Eligibility criteria:
inclusion criteria: * 1. aged over 18 years old; 2. liver function child-pugh classification a or b; 3. patients with chronic liver disease who meet the diagnostic criteria for high-risk groups of liver cancer in the "guidelines for the diagnosis and treatment of primary liver cancer (2022 edition)"; 4. equipped with gd-eob-dtpa enhanced mri scan images, including t1 mapping, t2 mapping, t2\* mapping, t1ρ and other sequences; 5. with 5-year follow-up data. exclusion criteria: * 1. patients who are unable to undergo mri scanning due to claustrophobia, abnormal renal function, etc.; 2. patients who have undergone liver surgery in the past; 3. patients with major diseases such as heart failure and tumors.
phase iv eortc quality of life module for patients with chronic myeloid leukemia

Conditions: Chronic Myeloid Leukemia

Summary: the objective of this study is to test the scale structure, reliability, validity and responsiveness to change of the qlq-cml24 in conjuction with the qlq-c30 for patients diagnosed with cml, and to investigate longitudinal relationship between satisfaction with information provision and qol outcomes.


Eligibility criteria:
inclusion criteria: * above 18 years of age. * patient with confirmed diagnosis of philadelphia chromosome positive and/or bcr-abl positive chronic myeloid leukemia (cml). * written informed consent. * patients enrolled in investigational drug-trials or other type of clinical trials are also eligible. exclusion criteria: * patients with a psychiatric condition or major cognitive impairment (as evaluated by their treating physician) that would hinder completion of self-reported health-related qol questionnaires. * patients who are unable to speak and read the language of the questionnaire.

Keywords: chronic myeloid leukemia; quality of life
infective endocarditis surgery using conventional prosthetic valves versus cryopreserved aortic homograft

Conditions: Infective Endocarditis; Heart Failure

Summary: : evidence suggested that autologous or allogeneic tissue is more suitable to synthetic material in an infected field. given the unwillingness of some surgeons to use artificial foreign materials, such as conventional mechanical or stent xenograft valve prostheses, cryopreserved aortic homografts (cah) have been recommended revealing favorable outcomes in aortic valve endocarditis (ave) surgery (1-5). this aspect is even more evident in cases involving prosthetic valve endocarditis (pve) and other complex and aggressive lesions involving the aortic root and intervalvular fibrosa with abscess formation. however, most of these reports are fixed on single-arm observational studies without comparing cah with conventional prostheses. the key question of this study is to establish the difference in treatment failure (death, recurrent aortic valve regurgitation and reoperation), all-cause and cause-specific (cardiac vs noncardiac) mortality, hospitalizations for heart failure during follow-up (structural/non structural valve deterioration, thromboembolism and recurrent endocarditis) in patients who received the cah vs conventional mechanical or stent xenograft valve prostheses for aortic valve replacement (avr) secondary to infective endocarditis (ie)

the target population enrolled in the study includes patients with aortic-valve endocarditis at risk of embolization, heart failure and uncontrolled infection undergoing avr with the use of cah or conventional mechanical or stent xenograft valve prostheses. individuals were adequately treated per applicable standards, including for the treatment of infection, lv dysfunction and heart failure. patients enrolled in the studies were nyha functional class ii, iii, or outpatient nyha iv. three groups of patients are included in the study. patients who were managed with cah, patients who received avr with conventional stented xenograft and recipients of avr undergoing surgery with the use of mechanical prostheses.

Eligibility criteria:
inclusion criteria: * duke criteria * uncontrolled infection local abscess large vegetation false aneurysm, fistula, dehiscence of pv * embolism large vegetation \>10mm, persistent infection * heart failure involvement of aortic root, intervalvular fibrosa, pulmonary edema, cardiogenic shock exclusion criteria : * pediatric * any echocardiographic evidence of absence of ie

Keywords: ie ; cah ; avrpl ; root replacement; intervalvular fibrosa
psychological impact of covid19 among women undergoing infertility treatment

Conditions: Infertility Treatment; Women

Summary: in france, one couple in eight encounters difficulties to conceive. the diagnosis of infertility frequently leads to symptoms of anxiety and depression. these symptoms appear to be higher than in the general population. some recent studies have looked at the relationship between anxiety and depression in art cares. results are controversial, but it appears that patients with lower levels of anxiety and depression have higher pregnancy rates. moreover, in couple, women seem to have more symptoms of anxiety and depression than men. first epidemiological studies related to the covid 19 pandemic have shown strong psychological impact on the general population with an anxiety rate estimated at more than 30%. with covid 19 pandemic and cessation of art, it is highly likely that psychic symptoms of anxiety or even depression may have appeared or worsened in women undergoing infertility treatment.


Eligibility criteria:
inclusion criteria: * consulting the center between 01/01/2020 to 12/31/2020 * email address in the medical records * all causes of infertility exclusion criteria: * women followed for: * preservation of fertility * oocyte donation * women who do not speak or read french

Keywords: psychological response infertility treatment lockdown period
an observational study of subcutaneous implantable cardioverter defibrillator in patients with hypertrophic cardiomyopathy at high risk of sudden cardiac death

Conditions: HCM - Hypertrophic Cardiomyopathy; S-ICD System (implantable Defibrillator)

Summary: 1. to observe the failure rate of s-icd screening in hcm patients at high risk of scd. 2. to observe the incidence of ias in hcm patients with s-icd implantation and explore the related factors of ias.

the study was a multicenter, prospective, observational study that prospectively included hcm patients assessed as meeting the icd implantation indication at fuwai hospital and national collaborative hospitals from july 1, 2024 to june 30, 2027, for pre-operation screening of s-icd, and follow-up of patients eventually implanted with s-icd.

Eligibility criteria:
inclusion criteria: * hcm patients assessed as meeting the icd implantation indication exclusion criteria: * combined with bradycardia with pacing indications; * frequent monomorphic ventricular tachycardia require atp therapy; * with indications of crt; * combined with other diseases, life expectancy is less than 1 year.

Keywords: hcm s-icd