Kornimate/medical-research-clean huggingface dataset:
effects of vestibular rehabilitation therapy (vrt) on balance, speed and agility in post-concussion football players

Conditions: Concussion, Mild

Summary: traumatic brain injury (tbi) is one and utmost rampant attained neurological conditions which can happen in young adults. vestibular rehabilitation therapy can help them improve their balance, speed and agility.

total 40 sample size out of which were divided into control and experimental group. concussed football athletes with age ranging 15-25 year, those participating actively in the sports were included in the study in the region of kyber pukhtoonkhwa peshawar.

Eligibility criteria:
inclusion criteria: active male football player. age between 15-25 years. known cases of concussion were included in the study. those patients complaining mild vertigo \& participating in sports exclusion criteria: concussion other than sports. history of metabolic diseases. history of recent fractures.

Keywords: traumatic brain injury concussion vestibular rehabilitation therapy football balance
study evaluating rhil-11 in active crohn's disease

Conditions: Crohn Disease; Inflammatory Bowel Disease

Summary: the purpose of this study is to assess the activity of multiple doses of oral rhil-11 in patients with active crohn's disease (crohn's disease activity index \[cdai\] score from 220-400).


Eligibility criteria:
inclusion criteria: * documented, signed and dated informed consent to participate in this trial prior to any study related procedures being performed. * men and women age 16 years and over. * diagnosis of crohn's disease for at least 6 months that has been appropriately documented and confirmed by radiological studies, endoscopy (with histological examination preferred), or surgical pathology (patients with a diagnosis of crohn's disease for less than 6 months may be included if the diagnosis is confirmed by a biopsy characteristic of crohn's disease) exclusion criteria: use of the following medications within the specified time period prior to randomization: * nonsteroidal anti-inflammatory drugs (nsaids; including cyclooxygenase-2 \[cox-2\] inhibitors and \>500 mg/day acetylsalicylic acid) * codeine-containing compounds * corticosteroid enemas

Keywords: crohn's disease active crohns disease
visible light study

Conditions: Skin Disease; Pigment Disorders

Summary: the purpose of this study is to learn more about the potential effects of visible light on the skin. more specifically, this study will examine whether an incandescent lamp (light bulb) or led light bulb can cause skin to become darker. investigators will determine the minimum threshold dose required to achieve immediate pigmentation darkening (ipd), persistent pigmentation darkening (ppd), and delayed tanning (dt) for fitzpatrick skin types iv - vi utilizing two visible light sources.


Eligibility criteria:
inclusion criteria: * be a healthy volunteer with fitzpatrick skin types i-vi; * agree to abide by the investigator's guidelines regarding photosensitizing drugs and photoprotection; * be able to understand the requirements of the study, the risks involved, and be able to sign the informed consent form; * agree to follow and undergo all study-related procedures. exclusion criteria: * women who are lactating, pregnant, or planning to become pregnant; * patients with a recent history of vitiligo, melasma, and other disorders of pigmentation with the exception of post-inflammatory hyperpigmentation; * patients with a known history of photosensitivity disorders; * photosensitizing medications may be continued throughout of the study at the discretion of the investigator ; * patients with a known history of melanoma or non-melanoma skin cancers; * concomitant use of tanning beds; * sun exposure of the irradiated or control areas; * patients with serious systemic disease. * patients with a known history of hypersensitivity to adhesives including adhesive tape.

Keywords: fitzpatrick skin-type melanin ultraviolet light (uv)
gas supply, demand and middle ear gas balance: specific aim 2

Conditions: Upper Respiratory Infection

Summary: this study will test the hypothesis that constitutionally poorer eustachian tube function predisposes to middle-ear pathology during a viral upper respiratory infection.

the most well supported immediate cause of otitis media (om) is a pre-existing or concurrent viral upper respiratory tract infection (vuri). however, not all vuri episodes cause om and a variety of predisposing factors has been suggested to explain this selectivity. based on our preliminary work using a model of experimental viral infections in adults, we hypothesize that the constitutional efficiency of the eustachian tube (et) to supply the middle ear (me) with gas and thereby stabilize me pressure at near ambient is a primary risk factor for om during vuri. here, we test the hypothesis that constitutionally poorer et function (f) predisposes to me pathology during a vuri. specifically, we will use etf testing protocols relevant to the pressure-chamber to evaluate constitutional etf in ≈ 160 susceptible, adult volunteers who will be exposed to rhinovirus as part of our funded study entitled "social and psychological risks for infectious disease" (pi: s. cohen, pi: chp subcontract: wj doyle) and document the etf and me responses to infection over a 5-day post-exposure, cloister period. also, using protocols relevant to the pressure-chamber, we will evaluate constitutional etf in 80 children who will be enrolled into our funded study entitled "role of virus and genetic susceptibility in otitis media" (pi: cm alper) and followed for vuri and om from october through april. from both data sets, we will extract measures of etf efficiency and determine using logistic regression with appropriate control variables (e.g. demographic data etc) if a single or combination of etf variables predicts an abnormal me response in rhinovirus infected adults or om during a rhinovirus cold in children.

Eligibility criteria:
inclusion criteria: * participating/participated in one of the two identified studies exclusion criteria: * no longer meet inclusion/exclusion criteria of parent studies

Keywords: otitis eustachian tube virus middle ear disease
clinical study of phage therapy for chronic constipation efficacy and safety

Conditions: Pib Specific Phage; Intractable Constipation

Summary: the overall aim was to evaluate the efficacy of pib-specific phages for the treatment of refractory constipation through clinical studies, primarily for the publication of scientific papers and to guide the development of phage therapies. the purpose of this study will be subdivided into three aspects from three aspects: target exposure level, target occupation, and functional effects after acting on the target, including:1) the distribution of pib phage in the intestine of patients with refractory constipation;2) the killing effect of pib phage on pib bacteria in refractory constipation patients;and 3) therapeutic effect of pib phage on patients with refractory constipation.


Eligibility criteria:
inclusion criteria: * patients of both sexes, aged 18-70 years, with confirmed chronic constipation and positive fecal bacteria test for pib, agreed to participate in this experiment and signed an informed consent. exclusion criteria: * severe heart failure, hypertension, cerebrovascular disease (e.g. stroke, moyamoya disease, etc.); secondary constipation caused by psychotropic drug abuse; pregnant or lactating women.
a feasibility study of the regenercell™ autologous cell harvesting device for diabetic foot ulcers

Conditions: Diabetic Foot Ulcer

Summary: this prospective case series is to gain additional clinical experience in the treatment of diabetic foot ulcers, by documenting and relating patient history (including baseline wound characteristics) and clinical outcomes (incidence of healing, rate of healing, and patient and physician satisfaction) in a group of study participants for whom the regenercell™ autologous cell harvesting device (regenercell™) is used in combination with conventional therapy for the closure of diabetic foot ulcers (dfus). participants will receive regenercell™ treatment in addition to standard care (debridement, cleansing, dressings, offloading).


Eligibility criteria:
inclusion criteria: * the patient has stable diabetes mellitus according to investigators clinical judgement * diabetic foot ulcer * groups 1 and 2: ulcer surface area between 3 cm2 and 100 cm2 (inclusive) * group 1: 12-24 weeks in duration, no directly visible tendon or bone (university of texas ulcer grade 1a) * group 2: \>3 weeks in duration, university of texas ulcer grade 1b, 2a, 2b, 3a, 3b * no superficial skin infection (of the ulcer area) requiring intervention * adequate offloading and compliance must be achievable * the patient is 18 years of age or older * the patient is willing to complete all follow-up evaluations required by the study protocol * the patient is able to abstain from any other non-standard treatment of the ulcer for the duration of the study, unless medically necessary * the patient agrees to abstain from enrolment in any other interventional clinical trial for the duration of the study * the patient is able to read and understand instructions and give voluntary written informed consent * the patient is able and willing to follow the protocol exclusion criteria: * patients requiring intervention for peripheral arterial disease (pad) will be excluded from this study * severe peripheral arterial disease that is not reconstructible * pregnant/lactating females (self-reported or tested, per institutional requirements * use of non-inert dressings (silver, honey etc.) during the past 10 days * subjects who have evidence of connective tissue disorders (e.g. vasculitis or rheumatoid arthritis) under active treatment * the patient is known to have a pre-existing active condition that may interfere with wound healing, e.g. malignancy, autoimmune disease, immunocompromised blood borne diseases, the patient has aids, is hiv- or hepatitis-c positive, or currently has a severe dermatological disorder (e.g. severe psoriasis, epidermolysis bullosa, pyoderma gangrenosum). * the patient is taking, or has taken in the past 60 days, \>10mg of corticosteroids per day. * the patient has other concurrent conditions that in the opinion of the investigator may compromise patient safety or study objectives * the patient has a known hypersensitivity to trypsin or compound sodium lactate solution. * the patient is a vulnerable or protected adult * the patient is unable to follow the protocol * the patient is unable to provide consent
the prevalence of sympathetic overactivity in primary hypertensive patients.

Conditions: Essential Hypertension

Summary: the purpose of this nis is to assess the prevalence of sympathetic overactivity in patients with newly diagnosed essential hypertension.

mc md

Eligibility criteria:
inclusion criteria: * newly diagnosed essential hypertension patients will be eligible for the study. * average of two or more systolic bp readings ≥ 140mmhg or diastolic bp readings ≥ 90mmhg exclusion criteria: * history of coronary artery disease * history of diabetes

Keywords: the prevalence of sympathetic overactivity in hypertensive patients.
biomarkers for therapy response in drug-resistant tuberculosis

Conditions: Tuberculosis, Multidrug-resistant

Summary: multi-center, observational, prospective cohort study including patients with multidrug-resistant tuberculosis at different sites in germany. the aim the study is the identification of biomarkers for therapy response.

the increasing rates of multidrug-resistant (mdr) tuberculosis (tb) are causing great concern. the current study that will be conducted at different centers in germany. biomarkers for treatment response during the course of the tuberculosis therapy will be evaluated. the study will be conducted with funding of the german center for infection research (dzif).

Eligibility criteria:
inclusion criteria: * subjects with confirmed pulmonary mdr-tb * subject able and willing to give informed consent exclusion criteria: * hiv infection * physical or mental inability preventing study participation at the discretion of the investigator * member of a vulnerable or special population (prisoner, soldier, mentally ill, under guardianship) * age \<18 years.
theta burst stimulation to promote motor re-education in tetraplegia

Conditions: Quadriplegia/Tetraplegia

Summary: a repetitive, non-invasive brain stimulation technique referred to as theta burst stimulation can modulate corticomotor excitability and therefore has great rehabilitative potential for individuals with neurologic deficits, including individuals with spinal cord injury (sci). in particular, intermittent theta burst stimulation (itbs) can increase corticomotor excitability and may be a useful adjunct to physical rehabilitation to promote motor re-education after upper limb reconstruction in individuals with tetraplegia. upper limb reconstruction involves surgical transfer of a non-paralyzed tendon or nerve with a redundant or less important function to perform a more critical function. upper limb reconstruction is intended to help individuals achieve their goals related to activities of daily living and independence in the community. outcomes after reconstruction are variable and depend largely on the efficacy of motor re-education of the transferred muscle to perform a new function. the long-term goal of our research is to determine whether itbs combined with physical rehabilitation can improve motor re-education after reconstruction. as a first step, the purpose of this proposal is to determine the effect of itbs on corticomotor excitability of proximal muscles in nonimpaired individuals and two groups of individuals with tetraplegia: individuals with and without upper limb reconstruction.


Eligibility criteria:
inclusion criteria for all subjects with tetraplegia: * injury to the lower cervical spinal cord at least one year prior to the date of participation * motor function classified according to the american spinal injury association international standards for neurological classification of spinal cord injury at levels ranging from c5-c8 inclusion criteria for the subjects with tetraplegia and upper limb reconstruction: • at least one year post-operative from tendon or nerve transfer surgery of the upper limb exclusion criteria for all subjects with tetraplegia: * presence of concurrent severe medical illness, including unhealed decubiti, use of baclofen pumps, existing infection, cardiovascular disease, significant osteoporosis, or a history of pulmonary complications. * metal implant near head or neck * risk of seizure of history of seizures
the preventive role of fractionated laser resurfacing against actinic neoplasia in an at-risk geriatric population

Conditions: Actinic Keratoses; Aging; Non-Melanoma Skin Cancer

Summary: the purpose of this study is to determine if the fractionated laser resurfacing (flr) procedure can protect one forearm/wrist from precancerous actinic keratosis (aks) as well as prevent skin cancer in older subjects with active aks. this study builds on a similar study ongoing at the dayton veterans administration dermatology clinic. this study is also testing if a photograph of the skin can be used to predict where the aks and an skin cancers will form.


Eligibility criteria:
inclusion criteria: * adult males and females aged 60 and older * have at least 5 aks on each forearm/wrist, but no more than 10 to allow for easy monitoring * skin type fair (fitzpatrick i-ii) * females must be post-menopausal and not be on systemic hormone replacement therapy * able to comprehend procedures and risks exclusion criteria: * more than 10 aks on an extremity * aks that are large (2-3+, hyperkeratotic grade 3 lesions) * aks that are very thick (\>3 mm) * medical history of diabetes * history of poor wound healing or scarring * large tattoos that can interfere with study * other serious health issues and other skin diseases that could interfere with the study * recent (within 1 year) field therapies such as efudex cream or pdt to forearms/wrists. * planning to leave region in next 5 years * subjects with allergies to xylocaine will be excluded if they need this topical anesthetic.
key factors of leadless pacemaker implantation with implantation site, complications and prognosis

Conditions: Complication of Surgical Procedure; Pacemaker Complication; Pacemaker Syndrome

Summary: to investigate the relationship between key variables in leadless pacemaker implantation with implantation site, intraoperative complications and prognosis.

in this study, we aim to include patients implated with leadless pacemakers, collect key variables and other clinical data during implantation of leadless pacemakers, and observe the final implantation site, intraoperative complications and prognosis information of patients. this study aims to clarify the relationship between key variables in leadless pacemaker implantation with implantation site, intraoperative complications and prognosis, and provide data support for the standardization of leadless pacemaker implantation process in china.

Eligibility criteria:
inclusion criteria: * patient received implantation of leadless pacemaker * patient agreed to join into this study and signed informed consent exclusion criteria: * age \< 18 years * ventricular septal defect * history of mechanical tricuspid valve replacement * history of inferior vena cava filter placement * pregnant or plan to be pregnant within 2 years * life expectancy \< 1 year * patient was included in other studies that could introduce bias into this study

Keywords: leadless pacemaker complication prognosis
sarizotan in participants with parkinson's disease suffering from treatment associated dyskinesia

Conditions: Parkinson's Disease; Dyskinesia

Summary: the purpose of this study is to test multiple doses of sarizotan to establish a dose with maximal safety and efficacy for treating treatment associated dyskinesia in parkinson's disease participants.


Eligibility criteria:
inclusion criteria: * the participant is an out-patient * the participant presents with a diagnosis of idiopathic parkinson's disease * prior therapy with all registered parkinsonian medication is allowed exclusion criteria: * (for female participants) the participant is pregnant or lactating * the participant is participating in another clinical study or has done so within the past 30 days * the participant has received neurosurgical intervention related to parkinson's disease * the participant has relevant renal impairment * the participant has relevant hepatic impairment * the participant is suffering from any dementia or psychiatric illness * the participant has a history of allergic asthma

Keywords: parkinson's disease dyskinesia dyskinesia associated with dopaminergic treatment
a computer-based parent/adolescent hiv communication intervention for latinos

Conditions: HIV/AIDS; STD; Pregnancy

Summary: the purpose of this study is to examine the efficacy of a brief culturally appropriate and theory-based parental communication intervention designed to improve parent-adolescent sexual communication and reduce adolescent sexual risk behavior.

latino adolescents are at high risk for contracting hiv/aids. few individual and even fewer parent interventions have been developed to address this persistent problem. parent communication interventions provide an opportunity to enhance individual adolescent based approaches. however, there is a need for theory and culture based interventions focused on latino parents. the program implemented in this study was designed for parents, to indirectly help reduce the health risks of their adolescents, including unintended pregnancy and stds, including hiv/aids. the study has three aims regarding the examination of whether the computer based parental communication intervention is 1) associated with a greater increase in parents' comfort with, and quantity of communication; 2) associated with a greater increase in adolescents' intentions to abstain from sex and/or avoid unprotected intercourse and decreased self-reported intercourse and unprotected intercourse; and 3) feasible and acceptable to spanish dominant latino parents and their adolescent children.

Eligibility criteria:
inclusion criteria: * latino parents who have adolescents 14 to 17 years of age * spanish dominant or bilingual

Keywords: adolescents parents computer based latino sexual communication
acupressure in rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: the goal of this pilot trial is to better understand if acupressure is feasible and tolerable to people with rheumatoid arthritis.


Eligibility criteria:
inclusion criteria: - patient is being treated for rheumatoid arthritis (ra) at a rheumatology clinic at the university of michigan or another by rheumatologist and reports being prescribed at least one of the following medications: * methotrexate (trexall, rheumatrex) * hydroxychloroquine (plaquenil) * sulfasalazine (azulfadine) * leflunomide (arava) * tocilizumab (actemra) * tumor necrosis factor inhibitor (tnfi), including: adalimumab (humira) etanercept (enbrel) certolizumab pegol (cimzia) golimumab (simponi) infliximab (remicade) * abatacept (orencia) * tocilizumab (actemra) * janus kinase inhibitor (jaki), including: tofacitinib (xeljanz) baracitinib (olumiant) upadacitinib (rinvoq) o rituximab (rituxan) exclusion criteria: * visual or hearing difficulties that would preclude participation, * do not speak or read english * do not have access to smart phone with access to mobile applications * severe psychiatric disorders including history of substance abuse disorders, * individuals on high doses of opioids (over 100 oral morphine equivalents) * taking blood thinners, including warfarin (coumadin), dabigatran (pradaxa), rivaroxaban (xarelto), apixaban (eliquis), edoxaban (savaysa), or betrixaban (bevyxxa) * thrombocytopenia (low platelet count) * expecting to receive surgery within the next year for their ra * pregnancy or breast feeding, or anticipate pregnancy in next year, * actively applying for disability or compensation, or actively involved in litigation. * anything at the discretion of the principal investigator or study team

Keywords: acupressure acuwand metime
return to sport activities in patients surgically treated for flat foot in paeditric age

Conditions: Flat Feet; Surgery; Sports Physical Therapy

Summary: the surgery of arthrosis of the subtalar joint, carried out between 9 and 12 years of age, the aim is to restore and maintain the physiological alignment between the talus and the calcaneus during bone maturation. there are few articles in the literature that talk about the return to sport of pediatric patients after surgery. the aim of the study is to review patients operated on remotely kick heel and describe how they return in their sports (resilience, type of activities carried out, recovery times). the aim of this study is to evaluate the clinical and functional results of patients of age pediatric treated in the investigator's sc orthopedics pediatric traumatology department for flat feet with "calcaneostop" surgery. the study aims to describe the method of resuming sports activities, analyzing the timing and difficulties declared by patients after surgery, with the help of specific questionnaires.


Eligibility criteria:
inclusion criteria: * idiopathic flatfoot; * surgical treatment with arthrorisis of subtalar joint; * follow-up\> 48 months * completeness of the clinical-radiographic documentation. exclusion criteria: * diagnosis of secondary flat valgus foot; * flat foot treated with other techniques; * incomplete clinical documentation; * patients who refuse to undergo the study