Kornimate/medical-research-clean huggingface dataset:
spi-1005 treatment in severe covid-19 patients

Conditions: Covid19; Coronavirus; Coronavirus Infection; Corona Virus Infection

Summary: the study is a randomized, double-blind, placebo-controlled, dose escalation, multi-center clinical trial (rct) of spi-1005 in adult subjects with positive pcr test for novel sars-cov-2 (ncov2) and severe symptoms of covid-19 disease.


Eligibility criteria:
inclusion criteria: * adults ≥18 years of age * positive ncov2 pcr test by nasopharyngeal, oral, saliva, or respiratory sample * clinical signs, symptoms, and respiratory status consistent with severe covid-19 * score of 5-7 on the who ordinal scale * onset of severe covid-19 symptoms ≤7 days of study enrollment * subject is in-patient at time of randomization to study treatment * subject or legally authorized representative is willing and able to provide informed consent, and agrees for subject to comply with planned study procedures including reproductive requirements exclusion criteria: * female patients who are pregnant or breastfeeding. * participation in another interventional investigational drug or device study concurrently or within 30 days prior to study consent. * patients with impaired hepatic or renal function. * subject has any other illness or condition that, in the opinion of the investigator, would prohibit the subject from participating.

Keywords: ebselen spi-1005 covid-19 covid sars-cov-2 mpro main protease plpro papain-like protease
ondansetron for postspinal anesthesia hypotension

Conditions: Adverse Effect

Summary: the purpose of this study is to investigate the effectiveness of ondansetron for postspinal anesthesia hypotension in patients undergoing cesarean section.

post-spinal anesthesia hypotension is a frequent complication during spinal anesthesia for cesarean section. the incidence of post-spinal anesthesia hypotension is as high as 62.1-89.7% if prophylactic measures are not taken. ondansetron have been highly demonstrated for prevention and/or treatment of post-spinal anesthesia hypotension. however, whether ondansetron could further reduction the incidence of post-spinal anesthesia hypotension is still unknown. the purpose of this study is to investigate the effectiveness of ondansetron for postspinal anesthesia hypotension in patients undergoing cesarean section.

Eligibility criteria:
inclusion criteria: * 18-40 years * primipara or multipara * singleton pregnancy ≥ 37 weeks * american society of anesthesiologists physical status classification i to ii * scheduled for elective cesarean section under spinal anesthesia exclusion criteria: * body height \< 150 cm * body weight \> 100 kg or body mass index (bmi) ≥ 40 kg/m2 * eclampsia or chronic hypertension or baseline blood pressure ≥ 160mmhg * hemoglobin \< 7g/dl * fetal distress, or known fetal developmental anomaly

Keywords: ondansetron coload hypotension cesarean section
the efficacy of electrical version of patient reported outcome

Conditions: Spinal Disease

Summary: recently the importance of electrical pro system is increased for the accuracy, convenience, and efficiency for both patients and physicians. for the evaluation of quality of life, various self-reported questionnaires is filled-out by the patient, mostly in front of outpatient clinic, and doctor usually take times to calculate the score. if there is electrical pro which is available with mobile device, the efficacy of clinic would be improved. the investigators developed such a system and applied the system for patients with spinal disease. the investigators assessed the effectiveness of application of electrical-pro in outpatients' clinic for patients who had filled-up same questionnaire in paper version.

age, sex, education levels, use of smartphone, the number of applications.

Eligibility criteria:
inclusion criteria: * we assessed the effectiveness of application of electrical-pro in outpatients' clinic for patients who had filled-up same questionnaire in paper version exclusion criteria: * computer illiterate * uncooperative patient

Keywords: outcome assessment self-reported patient clinical outcome
neoadjuvant treatment based on gastric cancer molecular subtyping.

Conditions: Advanced Gastric Cancer; Neoadjuvant Therapy; Multi-omics Analysis

Summary: extensive research employing diverse omics methodologies has unveiled a varied landscape of gastric cancer (gc). recent progress in next-generation sequencing and other genomic technologies has facilitated a more intricate exploration of gc at the molecular level. this study aimed to identify the most effective drug therapeutics for patients with the mesenchymal subtype of gastric cancer.based on rna-seq transcriptome, 234 patients were divided into four molecular subtypes: mesenchymal, immunogenic, metabolic, and classic.our analysis has revealed that, for neoadjuvant therapy in advanced gastric cancer (agc), the mesenchymal subtype stands out as the ideal patient population benefiting from apatinib, without a concurrent increase in postoperative complications.

the advent of immunotherapy and targeted therapies has recently provided new options for agc treatment. however, not all patients benefit from immunotherapy or targeted therapy, resulting in unsatisfactory overall treatment outcomes during the perioperative period. an ineffective treatment imposes significant financial burden, causes drug-related side effects that deteriorate their quality of life, and potentially delays subsequent treatment. evaluate the objective response rate (orr) of the combination of camrelizumb, apatinib, and neoadjuvant chemotherapy for the treatment of advanced gastric patient median survival time (os); disease free survival time (dfs);

Eligibility criteria:
inclusion criteria: * diagnosed with gastric adenocarcinoma and received neoadjuvant therapy exclusion criteria: * patients with distant metastases, gastric stump cancer, or missing neoadjuvant chemotherapy data were excluded from the study.
self-compassion and quality of life after dementia diagnosis

Conditions: Dementia

Summary: this study aims to investigate whether self-compassion is associated with older adult's quality of life after a diagnosis of dementia, and whether perceived threat posed by dementia mediates this relationship. self-compassion has been found to be positive in supporting individuals in times of difficulty, in adjustment processes and older adults' wellbeing. while different factors have begun to be identified which are associated with individuals' psychological wellbeing and adjustment following a dementia diagnosis, little is known about the influence of self-compassion. participants will be recruited via nhs memory clinics, join dementia research and from the community via third-sector organisations. individuals will be invited to attend a microsoft teams/telephone appointment in which informed consent and cognitive screening processes will take place at the start. eligible participants will then be invited to continue to complete measures administered by a researcher and an interview question. participants will be offered the opportunity to complete the measures in a second session (within 8 weeks) or using the online survey software, qualtrics, if preferred. a small pilot study (n = 5) will take place prior to the main study.


Eligibility criteria:
inclusion criteria: * an older adult aged ≥ 65 years * a confirmed diagnosis of dementia received within the past 12 months * they have knowledge of their diagnosis * they have english language proficiency * they have capacity to give informed consent to participation. exclusion criteria: * they are deemed to lack capacity to give informed consent to participate (as per the mental capacity act, 2005). * they have a diagnosis of early-onset dementia, defined as individuals who are aged \< 65 at diagnosis * a score on the moca blind (nasreddine, 2022b) screening measure of \<7 out of 22, which is calculated as equivalent to \<10 out of 30 on the moca (nasreddine et al., 2005).

Keywords: dementia self-compassion quality of life
middle and inner ear malformation in children with velocardiofacial syndrome

Conditions: Ear Malformations in the Velocardiofacial Syndrome

Summary: middle and inner ear malformations on two boys with velocardiofacial syndrome are discussed.special attention should be given to the presence of hearing loss due to middle and inner ear malformations, in addition to frequent conductive hearing loss regarding mastoid and middle ear inflammatory processes.

two boys with clinical signs of velocardiofacial syndrome, at ages of 4.7 and 6,7 years old are the subjects of this study.audiological evaluation, including pure tone audiometry, tympanometry, acoustical reflex, and computerized tomography of temporal bones, and analyses of dna sample with markers of 22q11 region were performed.

Eligibility criteria:
inclusion criteria: * subjects with velocardiofacial syndrome

Keywords: syndrome velocardiofacial middle ear inner ear malformation
performance of the variation in arterial lactatemia during a spontaneous breathing trial (sbt) in the prediction of extubation failure

Conditions: Extubation Failure

Summary: extubation failure (ef) is independently associated with excess mortality of critically ill patients. to avoid ef, critically ill patients being weaned from invasive mechanical ventilation (imv) perform spontaneous breathing trial (sbt), which is the litmus test for determining the ability to breathe without a ventilator. thus, the performance of the sbt during weaning from imv to predict successful extubation is crucial. the investigators hypothesize that patients with ef increase arterial lactate concentration during sbt due to increased work of breathing and hypoxia. the aim of this study is to evaluate the performance of variation in arterial lactate concentration before and after sbt in predicting successful extubation in critically ill patients.

extubation failure (ef) is defined as the need for reintubation within 48-72 hour. this complication is independently associated with a seven-fold increased risk of death in critically ill patients. to avoid ef, critically ill patients being weaned from invasive mechanical ventilation (imv) perform spontaneous breathing trial (sbt), which is the litmus test for determining the ability to breathe without a ventilator. however, ef occurs in 10 to 20% of patients despite having successful sbt. thus, the performance of the sbt during weaning from imv to predict successful extubation is crucial. previous studies of predictive markers of ef have been performed primarily to assess weaning failure from cardiac origin. the investigators hypothesize that critically ill patients who are going to have ef increase arterial lactate concentration during sbt due to increased work of breathing and hypoxia, regardless of the cause of failure. the aim of this study is to evaluate the performance of variation in arterial lactate concentration before and after sbt in predicting successful extubation in critically ill patients.

Eligibility criteria:
inclusion criteria: * adult ≥ 18 years old * intubation and ventilation \> 24 hours exclusion criteria: * patients under guardianship or curators * opposition to participation in the study by the patient or family member * patients with tracheotomy * pregnant or breast-feeding women

Keywords: extubation failure spontaneous breathing trial (sbt) lactatemia
eo footprint as a landmark during daa tha

Conditions: Coxarthrosis

Summary: one of the goals of total hip arthroplasty (tha) is to reconstruct leg length as adequately as possible. in order to achieve this one needs landmarks that are visible both on the templating x ray as well as during surgery. the classical posterior and lateral approaches often rely on the distance from the greater trochanter (gt) to the shoulder of the femoral stem or the distance from the lesser trochanter (lt) to the side of the neck osteotomy. if the surgeon finds out on the digital template that the distance from the gt to the shoulder of the implant should be x mm to achieve equal leg length, than the surgeon can try to reconstruct this during surgery. during the direct anterior approach (daa) these landmarks usually are not visible or require additional dissection injuring important soft tissue structures along the way. one anatomical structure that appears to be always visible during the daa is the external obturator tendon (eo). it was recently confirmed that the level of insertion of the eo onto the proximal femur can also always be determined on pre-operative x rays. it therefore represents one of the few landmarks that is visible both on the templating x ray as well as during daa tha. indeed, many hip surgeons, including ourselves, believe that if the shoulder of the femoral stem is near the insertion of the eo leg length cannot be far off. however, there is no clinical data to support this. the investigators would therefore like to the correlate the distance observed intra-operatively to the actual established distance on the post-operative x ray.


Eligibility criteria:
inclusion criteria: * all patient who underwent tha via daa by a single surgeon who routinely documents the distance from the shoulder of the stem to the upper border of the eo tendon exclusion criteria: * distance not noted * no radiographs available

Keywords: total hip arthroplasty leg length templating direct anterior approach external obturator footprint
safety and effectiveness of the jada system in treating primary postpartum hemorrhage

Conditions: Postpartum Hemorrhage

Summary: the purpose of this study is to evaluate the safety and effectiveness of the jada system in the control and reduction of primary postpartum hemorrhage.

this ide study is designed to evaluate the effectiveness and safety of the jada system to treat primary pph. the study is literature controlled.

Eligibility criteria:
inclusion criteria: 1. adult female, 18 years of age or older at time of consent. 2. able to understand and provide informed consent to participate in the study. 3. diagnosis of pph with suspected atony within 24 hours after vaginal or c-section delivery. 4. ebl, to be determined when investigator is ready to have jada peel pack opened: a) vaginal delivery: 500 - 1500 ml ebl or b) c-section delivery: 1000 - 1500 ml ebl. 5. failed first-line intervention of uterotonics and uterine massage/bimanual compression to stop bleeding. note: uterotonic administration may continue concomitant with and post jada use. exclusion criteria: 1. ebl \> 1500 ml, to be determined when investigator is ready to have the jada peel pack opened. 2. delivery at a gestational age \< 34 weeks. 3. for c-sections: cervix \< 3 cm dilated before jada use. 4. pph that the investigator determines to require more aggressive treatment, including any of the following: a) hysterectomy, b) b-lynch suture, c) uterine artery embolization or ligation, d) hypogastric ligation. 5. known uterine anomaly. 6. ongoing intrauterine pregnancy. 7. placenta abnormality including any of the following: a) known placenta accreta, b) retained placenta with known risk factors for placenta accreta (e.g. history of prior uterine surgery, including prior c-section and placenta previa), c) retained placenta without easy manual removal. 8. known uterine rupture. 9. unresolved uterine inversion. 10. subject has undergone intrauterine balloon therapy or uterine packing for tamponade treatment of this pph prior to use of the jada. 11. current cervical cancer. 12. current purulent infection of the vagina, cervix, uterus. 13. diagnosis of coagulopathy.

Keywords: postpartum hemorrhage
a comparison of microrna samples in patients with nasal polyps and aspirin exacerbated respiratory disease and those with nasal polyps only

Conditions: Aspirin-exacerbated Respiratory Disease; Nasal Polyp

Summary: we hypothesize that the mirna expression in subjects with nasal polyps and aspirin-exacerbated respiratory disease (aerd) differs from the mirna expressed in subjects with nasal polyps but without aspirin-exacerbated respiratory disease (aerd).

nasal epithelial tissue will be collected from the inferior nasal turbinates of ten subjects with nasal polyps and aerd disease and from the inferior turbinates of ten subjects with nasal polyps but without aerd. a rhinoprobe™ will be used to collect this epithelial tissue. these samples will be analyzed by mirna assay to determine if there is a difference in mircrorna expression between the two subject groups.

Eligibility criteria:
inclusion criteria: * ages eligible for study: 18 to 70 years * genders eligible for study: male and female * signed and dated written informed consent is obtained prior to study * subjects have a physician diagnosis of nasal polyps without aerd or physician diagnosis of nasal polyps with aerd. the diagnosis of aspirin sensitive asthma must be present for a minimum of three months. if the medical history is indeterminate either an aspirin challenge will be required to confirm or rule out the diagnosis. an aspirin challenge is a protocol that can safely be performed as an out patient procedure with close supervision. exclusion criteria: * pregnant and/or lactating females. * current tobacco use. * severe psychiatric illness. * current illicit substance use or dependence and/or abuse of alcohol. * primary or secondary immunodeficiency. * any clinically significant uncontrolled medical condition that would put the patient at risk.

Keywords: aspirin-exacerbated respiratory disease nasal polyp
rehabilitation status of children with cerebral palsy and anxiety of their caregivers during the covid19 pandemic

Conditions: Cerebral Palsy; Covid19; Anxiety

Summary: rehabilitation status of children with cerebral palsy (cp) and anxiety of their caregivers during the covid19 pandemic were explored. 206 caregivers who voluntarily accepted to participate were administered the state-trait anxiety inventory and evaluated about the rehabilitation status of their children.the anxiety levels of all caregivers were found high and the rehabilitation programmes of the children were interrupted.

investigators aimed to explore the rehabilitation status of children with cp and anxiety of their caregivers during the covid19 pandemic. caregivers of children with cp who were under follow up in the outpatient cp clinic were called up during pandemic period. 206 caregivers who voluntarily accepted to participate were administered the state-trait anxiety inventory and evaluated about the rehabilitation status of their children. demographic data, associated problems of children, gross motor function classification system (gmfcs) and manual ability classification system (macs) levels were recorded from their files. for the statistical analysis, ibm spss statistics 22 (spss ibm, turkey) programs were used. while evaluating the study data, the suitability of the parameters to the normal distribution was evaluated with the shapiro wilks test. significance was evaluated at the p \<0.05 level.

Eligibility criteria:
inclusion criteria: * caregivers of children with cp who were under follow up in the outpatient cp clinic who voluntarily accepted to participate exclusion criteria: * caregivers of children with cp who were under follow up in the outpatient cp clinic who didn't accept to participate

Keywords: anxiety cerebral palsy covid19 rehabilitation
quality of life during different regimens of combined hormonal contraceptives in women of reproductive age

Conditions: Hormonal Contraception

Summary: the aim of the present study is to investigate the psychosexual effects of combined hormonal contraception regimens, comparing them in terms of estrogen type and dosage, hormonal combination regimen and different routes of administration, in women seeking a hormonal contraception method to prevent unwanted pregnancies. in particular, the study focuses on the incidence of mood disorders and sexual dysfunctions associated with distress in the entire study population using combined hormonal contraception. it will also examine the incidence of these conditions under the influence of specific combined hormonal contraceptives, as well as whether different types of progestins and the route of administration (oral, vaginal or transdermal) may affect the occurrence of mood disorders and sexual dysfunctions.


Eligibility criteria:
inclusion criteria: * women of childbearing age (aged 18-40) who seek advice for use of combined hormonal contraception (chc). * stable relationship

Keywords: combined hormonal contraception female sexual dysfunction mood disorders
sociable seniors optimizing community integration to advance better living with esrd

Conditions: ESRD; Social Behavior; Physical Disability

Summary: this research is being done to find out the best ways to help people with end stage kidney disease take care of their daily lives and improve their social functioning. investigators want to learn whether services in the community aging in place, advancing better living for elders (capable) study such as help with medications, muscle strengthening, balance training, pain management, changes to houses and improved social support can be tailored to fit the needs of older adults with kidney disease to help improve their ability to balance, walk, and take care of themselves. people aged 60 years and older who have end stage kidney disease and have been receiving dialyses for at least 6 months, may join.

questionnaires: participants will be asked to answer questions about: * social support and social functioning * pain and depression * physical function study intervention: participants will be randomly assigned (by chance, like the flip of a coin) to one of two groups: participant either will receive sociable (seniors optimizing community integration to advance better living with esrd) services now, or will receive the same services in six months from now. participants have a 50:50 chance of getting into each group sociable services involve receiving visits with a nurse interviewer. participants will decide how you want to improve your social function and social support. participants will also receive: * a group of services called capable which include home visits from a nurse (rn) and an occupational therapist (ot) and a handyman for repairs if you need them and * help with improving social support all participants will receive 10 home visits (6 ot, 4 rn) plus minor home repairs and assistive devices over a 4 month period of time.

Eligibility criteria:
inclusion criteria: * 60 years and older * end stage renal disease on in-center hemodialysis for at least 6 months * functional limitations (difficulty in at least one of the following: bathing, dressing, walking across a room, grooming, getting on or off the toilet, getting on or off the bed); * low socioeconomic status (less than high school education, or household income \<$25,000/year) * signed informed consent exclusion criteria: * inability to understand the informed consent process and give consent via signed written consent form
fitness and nutrition in glioma

Conditions: Malignant Glioma

Summary: this is a pilot study assessing the effects of combining a modified atkins diet with a physical fitness regimen in patients with malignant glioma. a sample size of 15 participants will be enrolled in a 15-week program consisting of two weekly supervised exercise sessions combined with an individualized home exercise program and a modified atkins diet.


Eligibility criteria:
inclusion criteria: * tissue confirmed diagnosis of high-grade glioma (world health organization grade iii or iv) * karnofsky performance status (kps) ≥ 70% * willing to follow the study intervention and follow-up * able to give full informed consent exclusion criteria: * currently undergoing initial concurrent radiation/chemotherapy * severe medical co-morbidities * any medical condition which prohibits moderate to vigorous physical activity (60-85% hrmax) * any medical condition which prohibits a restrictive diet * neurological deficit preventing participation in moderate to vigorous physical activity * severe psychiatric illness