Kornimate/medical-research-clean huggingface dataset:
evaluation of efficacy and accuracy of aquamantys device in general surgery

Conditions: Cancer, Hepatocellular; Pancreatectomy

Summary: the purpose of this study is to test the efficacy and accuracy of the aquamantys device.

the primary objective of this study is to assess the efficacy of placement and accuracy of the aquamantys device in 20 patients that require general surgery. high frequency electrosurgery is the application of frequency in the range of 300 khz up to several mhz in order to coagulate or destroy tissue. due to technological advancements, knowledge of how frequency and other physical modes interact with biological materials has become increasingly important in order for the surgeon to provide a safe and consistent surgery. the aquamantys system utilizes radiofrequency energy and saline irrigation for cutting tissue and stopping excessive bleeding. the aquamantys system features the following: 1. cone-shaped electrodes designed to aid blunt dissection; 2. large bipolar electrode configuration allowing for hemostatic sealing across broad planes of tissue; 3. bipolar electrodes alleviate the need for grounding pad; 4. transcollation technology allows for controlled depth of energy penetration. during surgery, the aquamantys device will be utilized in order to stop excessive bleeding and to cut vessels. the patient will be monitored by the surgeon and research nurse coordinator before surgery, intra-operatively and post-operatively until discharge from the hospital. the study participant will follow-up post-operatively with the surgeon per standard of care.

Eligibility criteria:
inclusion criteria: * indication for general surgery to include: liver resection and pancreatectomy * male or females age 18 years of age or older exclusion criteria: * indication for emergency surgery * suspected inability, e.g. language problems or the inability to comply with trial procedures * employee at the investigational center, sponsor or sponsor's representative, relative or spouse of the investigator * females who are pregnant or breastfeeding
randomized controlled trial targeting obesity-related behaviors

Conditions: Obesity

Summary: the intervention included biweekly access to group fitness classes, with (group 1) or without (group 2) weekly nutrition and physical activity education sessions. outcome measures were assessed at baseline and immediately post intervention and included bmi, waist circumference, blood pressure, physical activity and dietary behaviors, and psychosocial variables.

this 15-week randomized controlled pilot study consisted of two groups. all participants received access to two group fitness classes per week, which were offered free of charge at the caswell county parks and recreation building. zumba classes were offered one night a week, and the other evening was a 'potluck night' designed to increase participants exposure to a variety of other fitness classes such as floor aerobics, kickboxing, line dancing, and african dancing. participants in the intervention group (group 1) were enrolled in eat smart, move more, weigh less (esmmwl) where they received on hour weekly education classes on healthy eating and physical activity. the esmmwl curriculum is a 15-week weight-management program that is delivered by local educators. published research data were used to identify strategies that would lead to weight loss and/or weight maintenance. the program uses the theory of planned behavior, and as such informs, empowers, and motivates participants to live mindfully as they make choices about eating and physical activity. the program provides opportunities for participants to keep a journal of healthy eating and physical activity behaviors.

Eligibility criteria:
inclusion criteria: * \>18 years of age, * english-speaking, * no self-reported contraindications to exercise * eligible participants where scheduled an enrollment appointment. at this appointment, participants with blood pressure over 180/110 were directed to obtain immediate medical attention and were only eligible to enroll upon written consent from their physician exclusion criteria: * \<18 years of age * non-english-speaking * self-reported contraindications to exercise * blood pressure over 180/110 without medical clearance

Keywords: randomized controlled trial obesity community-based participatory research minority health rural health health promotion
stratagraft overlay of meshed autograft in full-thickness thermal burns

Conditions: Full Thickness Thermal Burn

Summary: autografting is a surgical procedure to transplant healthy skin (donor skin) from another part of the participant's own body (donor site) to the burned part. autografting is the usual treatment for full-thickness (ft) burns. it works to close the wound, but can cause other problems: * donor sites are painful, can become infected or scarred, or can even become ft wounds themselves * treatment problems can require more grafting * additional surgery increases risk of medical problems caused by the treatment stratatech is trying to find a safe and effective treatment option for severe burns that uses less donor skin. all participants in this study received meshed autograft on one part of their burn (ag tx). they received more widely meshed than ag tx site autograft with a stratagraft covering (soma tx) on a different part of their burn.


Eligibility criteria:
inclusion criteria: * has 2% to 49% (inclusive) total body surface area (tbsa) thermal burn area, including areas of full thickness (ft) injury clinically indicated for surgical excision and autografting, appropriate for protocol-defined treatment areas * meets protocol-specified criteria for qualification and contraception * is willing and able to comply with all study procedures and requirements * voluntarily consents to participate and provides written informed consent prior to any protocol-specific procedures exclusion criteria: * is a prisoner, pregnant, or had previous autografting to treatment sites * is expected to survive less than 3 months * is participating in another interventional trial, or did within 30 days before enrollment * has anticipated treatment sites that are outside protocol-specified parameters * has concurrent clinically significant inhalation injury, inadequate fluid resuscitation, or burns of chemical or electrical (non-thermal) etiology * has other signs, symptoms or history of any condition that, per protocol or in the opinion of the investigator, might compromise: 1. the safety or well-being of the participant 2. the study objectives
neoadjuvant gemcitabine/oxaliplatin plus adjuvant gemcitabine in resectable pancreatic cancer

Conditions: Pancreas Cancer

Summary: the aim of this study is to test the additional value of neoadjuvant chemotherapy to the standard treatment for resectable pancreatic cancer (surgery + adjuvant chemotherapy). this study will be performed in compliance with the study protocol, gcp (good clinical practice) and the applicable regulatory requirements.


Eligibility criteria:
inclusion criteria: * resectable adenocarcinoma of the pancreatic head (requiring duodeno-pancreatectomy) * t1-3, nx, m0 (uicc 6th version, 2002) * infiltration of the portal vein (\<180°) is not an exclusion criterion * cytologic or histologic confirmation of adenocarcinoma * age \>18 years * written informed consent exclusion criteria: * contraindication for whipple procedure * an infiltration \>180° of the portal vein * abutment of the tumor to the superior mesenteric artery * infiltration of the superior mesenteric artery or the celiac trunk * chronic neuropathy \> grade 2 * who performance score \>2 * uncorrectable cholestasis (bilirubin \> 100mmol/l despite drainage attempts for more than four weeks prior to inclusion) * female patients in child bearing age not using adequate contraception (oral or subcutaneous contraceptives, intrauterine pessars (iup), condoms) * pregnant or lactating women * mental or organic disorders which could interfere with giving informed consent or receiving treatments * second malignancy diagnosed within the past 5 years, except non-melanomatous skin cancer or non-invasive cervical cancer * percutaneous biopsy of the primary tumor

Keywords: adenocarcinoma pancreatic head
comparison between effects of active release technique and post isometric relaxation on adductor strain in mixed martial arts fighters

Conditions: Adductor Strain

Summary: this study is a randomized controlled trial and the purpose of this study is to compare the effects between active release technique and post-isometric relaxation on adductor strain in mixed martial arts fighters.

the purpose of this study is to compare the effects between active release technique and post-isometric relaxation on adductor strain in mixed martial arts fighters on flexibility, pain, range of motion, and functionality, in adults (age: 20-35 years ) 1. numeric pain rating scale 2. goniometer 3. bent knee fall out test 4. lower extremity functional scale data will be collected before and after the intervention protocol for each participant. data collection procedure: participants of interest would be approached and explained about the research. informed written consent will be taken. pre and post-intervention scores will be recorded.

Eligibility criteria:
inclusion criteria: * both male and female genders * ages 20-35 years * professional mixed martial arts fighters involved in kicking, sprinting, jumping, hiking * grade 1 or 2 adductor strain * clinical adductor dysfunction (pain reproduced by palpation of the enthesis, passive stretching of the adductors, and active resisted adduction) * numeric pain rating scale (nprs) 1-8 * positive bent knee fall out (bkfo test) exclusion criteria: * any clinical or radiographic evidence of pathological involvement of the hip joint (femoroacetabular impingement: pincer and/or cam features, dysplasia) * grade 3 adductor strain * history of recent fracture
metabolic syndrome prevalence study

Conditions: Metabolic Syndrome

Summary: following the first study conducted to investigate the prevalence of metabolic syndrome and its components in turkey, it was aimed to demonstrate the change in general health condition of available patients after the period of time lapsed. this study will provide important information on the social and economic dimensions of metabolic syndrome and will contribute to development of preventive programs.

in the first metsar-i study conducted in 2003, metabolic syndrome screening was made by two different team. participants were visited at their addresses and informed about the research study and gave written consent. they were invited on an empty stomach for hospital visit on the day after. pre-trained nurses completed the forms of patients during that second visit. after 11 years, a questionnaire by telephone survey will be applied to patients who participated in the metsar-ii study. the main goal is to determine the changes of metabolic syndrome population during that period.

Eligibility criteria:
inclusion criteria: * volunteers who participated in the metsar-i study in 2003 * patients who accepted to participate will be included the second follow up phase. exclusion criteria: none
investigation of the effect of systemic steroids on treatment and prevention of recurrent tracheal stenosis in postoperative patients

Conditions: Tracheal Stenosis

Summary: tracheal stenosis is the result of abnormal wound-healing processes leading to hypertrophic scar formation and obstruction of the airway lumen by excess granulation tissue. this process is progressive so treatment and prevention is essential. resection-anastomosis of the trachea is becoming the standard of care in many centers and gives the most consistent results in both adult and pediatric patients. but recurrence stenosis, re-granulation and re-inflammation are probable. this study aimed to assess the efficacy of systemic prednisolone on prevention of recurrent tracheal stenosis after surgery.

tracheal stenosis affects 4-13% of adults and occurs in 1-8% of neonates after prolonged intubation in united states. the causes of adults' tracheal stenosis include trauma, chronic inflammatory diseases, benign neoplasm, malignant neoplasm and collagen vascular diseases. the most common cause of tracheal stenosis continues to be trauma, which can be internal (prolonged endotracheal intubation, tracheostomy, flame, burn injury) or external (neck trauma). approximately 90% of chronic subglottic stenosis in children and adults results from endotracheal intubation or tracheostomy and about 10% results from other causes. the resection anastomosis is the most effective treatment to cure this condition. the other treatments are mechanical dilation (dilators, rigid bronchoscopes), stents, laser co2, diode, and cold knife. but they are not as effective as resection anastomosis. rigid bronchoscopes or dilators may shear the mucosa leading to further damage. resection of all damaged segments of the airway, approximation and anastomosis of the two intact ends by means of fine synthetic absorbable sutures with minimum tension. steroids with anti-inflammatory effect widely use as first line therapy for this condition. patients who underwent resection anastomosis during 2014-2016 for treatment of post-intubation tracheal stenosis will be included in this study. systemic prednisolone will be used for treatment and prevention of recurrent tracheal stenosis in post-operative patients. post-operative patients will divide in two groups, one of them will receive prednisolone and the other will receive placebo for 30 days. the results will be compared by bronchoscopy (fob or rigid) after 30 days.

Eligibility criteria:
inclusion criteria: 1. post-operative resection anastomosis patients. 2. age more than 10 years old. 3. no severe tension in surgery by the opinion of surgeon. exclusion criteria: 1. pregnancy 2. history of significant medical condition not controlled by medicines. ex: cardiovascular diseases, endocrine impairments and etc. 3. weight is ≥200% ideal body weight 4. severe chronic liver disease 5. immunosuppression including hiv+ status, history of bone marrow or solid organ transplantation, current malignancy, neutropenia 6. fungal systemic infection
a study to evaluate a range of dose levels of an adenovirus serotype 26 (ad26.rsv.pref)-based vaccine in older adults

Conditions: Healthy

Summary: the purpose of this study is to explore the dose-response relationship of immune responses induced by different dose levels of an ad26.rsv.pref based vaccine (cohort 1) and to assess the safety and reactogenicity of different dose levels of the ad26.rsv.pref-based vaccine (cohorts 2 and 3).


Eligibility criteria:
inclusion criteria: * in the investigator's clinical judgment, participants must be either in good or stable health. participants may have underlying illnesses such as hypertension, type 2 diabetes mellitus, hyperlipoproteinemia, or hypothyroidism, as long as their signs and symptoms are stable and medically controlled in the judgment of the investigator. participants will be included on the basis of medical history and of physical examination and vital signs performed at screening (all cohorts), and of physical examination and/or vital signs performed prevaccination on day 1 (cohorts 2 and 3) * a woman must be postmenopausal (defined as no menses for 12 months without an alternative medical cause) and not intending to conceive by any methods * agree to not donate blood from the time of vaccination until 3 months after vaccination * have a body mass index (bmi) less than (\<) 40 kilogram per meter square (kg/m\^2) * be willing to provide verifiable identification and have means to be contacted and to contact the investigator during the study exclusion criteria: * has a contraindication to intramuscular injection (im) injections and blood draws (example, bleeding disorders) * known allergy or history of anaphylaxis or other serious adverse reactions to vaccines or vaccine components (including any of the constituents of the study vaccine) * history of chronic urticaria (recurrent hives), eczema, or atopic dermatitis * has hepatitis b or c infection, including history of treated hepatitis c infection * received an active rsv vaccine in a previous rsv vaccine study or an ad26-vectored vaccine at any time prior to randomization
glaucoma, visual field loss, and their association with life space in older adults

Conditions: Primary Open Angle Glaucoma

Summary: mobility refers to a person's purposeful movement through the environment from one place to another and can be conceptualized as a continuum from bed bound (immobility) on one extreme to making excursions to distant locations on the other extreme. primary open-angle glaucoma (poag) is a chronic, progressive optic neuropathy that can lead to gradual loss of vision in the peripheral field and central vision. older adults with poag have an increased risk for motor vehicle collisions and falls. moreover, existing studies suggest that patients with poag exhibit more postural sway while standing as measured by a balance platform and also tend to walk more slowly than those who are normally sighted and free of ocular disease. while these disturbances likely influence mobility, there has been little research directly assessing the impact of poag on mobility. this study will assess the impact of poag on life space (one aspect of mobility) and will determine whether difficulties with life space are associated with difficulties experienced under conditions of dim lighting.

aim 1: to determine whether differences exist between people with healthy eyes and patients with poag in seeing under dim illumination (low luminance questionnaire) and to determine whether such differences are associated with life space. aim 2: to determine whether differences exist between people with healthy eyes and patients with poag in seeing under dim illumination (objective measures of visual function) and to determine whether such differences are associated with life space.

Eligibility criteria:
inclusion criteria (patients): * participants that are enrolled in the early detection of glaucoma progression using a novel individualized approach (irb-300000301) or in the african descent and glaucoma evaluation (adages) iv: alterations of the lamina cribrosa in progression (irb-161115004). exclusion criteria (patients): * not being enrolled in one of the following two nih-funded studies: 1. african descent and glaucoma evaluation (adages) iv: alterations of the lamina cribrosa in progression (ey026574) or 2. early detection of glaucoma progression using a novel individualized approach (ey025756) inclusion criteria (controls): * no diagnosis of eye disease exclusion criteria (controls): * cognitive impairment that would preclude ability to take the tests
structural and functional changes in supraspinatus tendinopathy thtough percutaneous electrolysis and neuromodulation combined therapy. a single-blinded randomized clínical trial.

Conditions: Supraspinatus Tendinitis

Summary: the supraspinatus muscle tendinopathy show a big impact, however, there is a lack of awareness about the options of the physiotherapist treatment. it is necessary to do studies about effectiveness of therapeutic percutaneous electrolysis and neuromodulation. this technique enables treatment of the tendinopathies. to analyze the effectiveness of therapeutic percutaneou electrolysis and neuromodulation in the treatment of supraspinatus muscle tendinopathy. single center randomized controlled trial, parallel treatment design. a specialist physician will be diagnosed the supraspinatus muscle tendinopathy. participants will be randomly assigned to receive treatmen for 4 weeks: percutaneou electrolysis and neuromodulation associated with eccentric exercises or conventional treatment of physiotherapy with the same eccentric exercises. both interventions were performed under ultrasound guidance with a portable ultrasound (general electric logice). data will be collected by a blinded evaluator.

eccentric exercises of the supraspinatus muscle were performed in 3 sets of 10 repetitions. participants were asked to perform the exercise program on an individual basis twice every day for 4 weeks. the eccentric program consisted of 3 exercises, focusing on the supraspinatus, infraspinatus, and scapular muscles. participants were asked to do a normal abduction (concentric phase) and a slow return to the initial position (eccentric phase) included first the concentric phase, and the eccentric phase was slowly conducted. the exercise program was taught by a physiotherapist in the first session and monitored in the subsequent sessions.

Eligibility criteria:
inclusion criteria: * patients diagnosed with supraspinatus tendinopathies that do not improve with conventional physiotherapy or pharmacological therapy protocols. * subjects who are in an active state of pain, who present painful symptoms in a sensitive and painful area of the tendon of insertion of the supraspinatus muscle in the humerus. exclusion criteria: * individuals who have received surgery intervention in the same shoulder, or have suffered fractures or dislocations in the same shoulder. * individuals have received the proposed treatment in one month´s period previously. * individuals who suffering from cervical radiculopathies, fibromialgia síndrome, cardiac patients with pacemakers, cancer, infectious processes, or generalized lymphedema. * pregnant women can not receive this treatment intervention.

Keywords: tendinopathy electrolysis exercise dry needling physiotherapy
melatonin level and postoperative analgesia consumption in bariatric surgery patients.

Conditions: Bariatric Surgery; Melatonin; POSTOPERATIVE PAIN

Summary: bariatric surgical procedures are associated with low short-term mortality and may be associated with long-term reductions in all-cause, cardiovascular, and cancer-related mortality. this surgeries are major surgeries include risk of mortality still. melatonin is a hormone secreted from the pineal gland. melatonin is an antioxidant, antinociceptive, hypnotic, anticonvulsant, neuroprotective, anxiolytic, sedative and analgesic. melatonin is neurohormone with the profile of a novel hypnotic-anesthetic agent. the purpose of this study is to investigate the preoperative, perioperative and postoperative melatonin levels in bariatric surgery under general anesthesia and to investigate the relationship between melatonin level and analgesia requirement.

bariatric surgical procedures are associated with low short-term mortality and may be associated with long-term reductions in all-cause, cardiovascular, and cancer-related mortality. this surgeries are major surgeries include risk of mortality still. melatonin is a hormone secreted from the pineal gland. melatonin is an antioxidant, antinociceptive, hypnotic, anticonvulsant, neuroprotective, anxiolytic, sedative and analgesic. irregularity of melatonin secretion causes a sleep irregularities, psychosis in intensive care unit and some behavioral disorder. the hypnotic, antinociceptive, and anticonvulsant properties of melatonin endow this neurohormone with the profile of a novel hypnotic-anesthetic agent. the purpose of this study is to investigate the preoperative, perioperative and postoperative melatonin levels in bariatric surgery under general anesthesia and to investigate the relationship between melatonin level and analgesia requirement.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) 3-4 status, aged between 18-65 years who are scheduled to undergo bariatric surgery. exclusion criteria: patients with cardiovascular and pulmonary disease, those with asa iii-iv and propofol, fentanyl, remifentanil and rocuronium allergy.