Kornimate/medical-research-clean huggingface dataset:
pilot study : freestyle libre pro flash continuous glucose monitoring system in subjects with diabetes on hemodialsis

Conditions: Kidney Failure; Diabetes

Summary: continuous monitoring of glucose with a freestyle libre pro sensor in diabetic and dialysis patients


Eligibility criteria:
inclusion criteria: * diabetes without any change in treatment in the last 3 months * hemodialysis for \> 3 months * recent laboratory hba1c (\< 15 days) exclusion criteria: * patient does not show non-opposition * skin allergy to the sensor * sepsis / acute anaemia

Keywords: glycemia diabetes kidney failure dialysis glucose sensor
improving the management of acute coronary syndromes in the emergency department

Conditions: Acute Coronary Syndrome

Summary: by using a rapid cardiac evaluation (race) pathway in the emergency department (ed), the investigators can effectively reduce ed wait times and ed length of stay by decreasing overall hospital admissions and telemetry admissions. in addition, the investigators hypothesize a decrease in mortality of those patients admitted for cardiac evaluation by increasing the patient to health care provider ratio.


Eligibility criteria:
inclusion criteria: * chief complaint of chest pain * 35 years old or greater exclusion criteria: * st elevation mi * new left bundle branch block * admission regardless of test result * leaving ed against medical advice

Keywords: acute coronary syndrome cardiac biomarkers point of care testing
the effect of holistic corrective exercise program

Conditions: Kyphosis Thoracic

Summary: this study was planned to investigate the effect of holistic approach corrective exercise program on the degree of kyphosis, balance and quality of life in kyphotic adolescents. a holistic approach corrective exercise program including corrective exercises and postural perception training was applied to one group. thoracic region focused exercise program was applied to the other group. the programs of the exercise groups were applied three days a week, for 12 weeks. the kyphosis angle of all individuals participating in the study was evaluated using the flexible ruler, the romberg index measured with balance pedobarography, and the quality of life using the scoliosis research society-22 questionnaire (srs-22). in our study, a decrease in the degree of kyphosis was detected in the holistic approach corrective exercise and thoracic region-focused exercise group after 12 weeks of exercise training (p\ 0.05). balance improved after exercise training in the holistic corrective exercise group (p=0.006). the quality of life increased in the holistic approach corrective exercise and thoracic region focused exercise groups after the training (p\<0.001). the use of postural perception training together with corrective exercise programs in applications for thoracic kyphosis reveals a holistic approach and may increase the effect of the intervention.


Eligibility criteria:
inclusion criteria: * male individual between the ages of 10-18, * kyphosis degree ≥50°, exclusion criteria: * rrigid thoracic kyphosis * scoliosis with a cobb angle \>10° * congenital spine problem, * shoulder, pelvis and other spinal injuries
the use of tocilizumab in the management of patients who have severe covid-19 with suspected pulmonary hyperinflammation

Conditions: Covid19 Pneumonia

Summary: title: the use of tocilizumab in the management of patients who have severe covid-19 with suspected pulmonary hyperinflammation. this is a study designed to assess the therapeutic value of intravenous tocilizumab administered as single 8mg/kg dose in patients affected by sars-cov2 infection with a pulmonary manifestation causing hypoxia. aim of the study is to test the hypothesis that anti-il6 treatment can be effective in reducing the virus-induced cytokine storm, blocking deterioration of lung function or even promoting a rapid improvement of clinical conditions, preventing tracheal intubation and/or death. this drug will be administered to those patients entering the icu with severe acute respiratory failure covid-19 disease. the endpoints are death and duration of hospitalization. the patients will be assessed with surrogate markers determining the level of the cytokine storm.

study design this is a multicenter, two arms, 2:1 (treatment: control) open-label randomized control study with a drug approved for another indication in israel. all the patients enrolled will be treated with tocilizumab or not. one-month mortality rate is the primary endpoint. one arm will be the study drug anti-il6r (tocilizumab (actmera)) 8 mg/kg given iv during one hour once. the placebo will be a 100 ml saline iv infusion administered along one hour.

Eligibility criteria:
inclusion criteria: 1. any gender 2. age 18 and older 3. informed consent for participation in the study 4. virological diagnosis of sars-cov2 infection (pcr) 5. acute respiratory failure 6. radiographic pneumonia, defined as any/ changing new lung infiltrate 7. patient breathing spontaneously, required more than 50% oxygen and mews score \> 7. 8. if intubated, intubated less than 24 hours with pao2/fio2 ratio ≤ 200 and peep ≥ 5 cm h2o. exclusion criteria: 1. known hypersensitivity to tocilizumab or its excipients 2. patient with a life expectancy of less than 6 months. 3. known active infections or other clinical condition that contra-indicate tocilizumab and cannot be treated or solved according to the judgement of the clinician. 4. neutrophils \<500 / mmc 5. platelets \<40.000 / mmc

Keywords: sars-cov-2 cytokine storm il-6
prospective evaluation of the efficacy and safety of submucosal endoscopy

Conditions: Gastrointestinal Neoplasia; Hirschsprung's Disease; Esophageal Obstruction; Gastroparesis; Spastic Esophageal Disorders; Zenker's Diverticulum

Summary: to test the idea that submucosal endoscopy is effective and safe for endoscopic myotomy, endoscopic submucosal dissection, and access for tissue acquisition and resection. submucosal endoscopy is a recent innovative addition to gastrointestinal endoscopy. this involves endoscopic maneuvers in the gut wall, by dissection of the submucosal layer of gi tract, thereby allowing endoscopic myotomy (incision of the muscle), endoscopic access for tissue acquisition and therapy, and resection of precancerous and cancerous gastrointestinal tissue. this approach has been a dramatic game-changer for minimally invasive management of various gastrointestinal conditions such as zenker's diverticulum, achalasia, spastic esophageal disorders, gastroparesis, esophageal obstruction, hirschsprung's disease, and gastrointestinal neoplasia. the aim of the proposed study is to prospectively assess technical success, clinical success, and adverse events after submucosal endoscopy. technical success will be defined as ability to successfully complete the submucosal endoscopic procedure. clinical success will be defined as symptom relief and objective evaluation which will be assessed with radiologic imaging, repeat endoscopy, gastrointestinal motility studies, and pathology results routinely performed post-procedure for clinical care, as indicated. adverse events will be recorded per published asge criteria. a database/ registry of patients undergoing submucosal endoscopic procedures will be created to demonstrate this.


Eligibility criteria:
inclusion criteria: 1. patients who will undergo submucosal endoscopy 2. age \>18 years exclusion criteria: 1. age \<18 years 2. pregnancy 3. coagulopathy (platelets less than 50, inr more than 1.8)
developmental profile of ocular refraction in patients with congenital cataract

Conditions: Cataract

Summary: the purpose of prospective cohort study is to describe the developmental profile of refraction change in a large cohort of chinese cc patients. the decisive factors to the range of myopic shift in unilateral cc appeared to be different from that in bilateral cc, indicating dramatic differences in the etiopathogenesis and refractive prognosis between bilateral and unilateral cc.

the refractive status is crucial to visual function and may change throughout life. for patients with congenital cataract (cc), the developmental profile of refraction is complicated due to the potential influences of diverse clinical manifestations and various treatments, and has not yet been fully characterized. the investigator described the developmental profile of refraction change in a large cohort of chinese cc patients. the decisive factors to the range of myopic shift in unilateral cc appeared to be different from that in bilateral cc, indicating dramatic differences in the etiopathogenesis and refractive prognosis between bilateral and unilateral cc. the refraction data from cc patients provided in the study are of clinical significance to the guidelines for cc treatment, especially for iol calculation concerning the laterality of cc.

Eligibility criteria:
inclusion criteria: * children with uncomplicated surgeries * children with unilateral/bilateral cataract exclusion criteria: * corneal diseases * lens luxation * glaucoma * retinal diseases * nystagmus and nanophthalmos
factor v leiden mutation and implantation failure

Conditions: Infertility

Summary: the purpose of this study is to determine whether inherited thrombophilias (tendency toward blood clotting) increase the risk of failure of the embryo to implant in ivf. the specific condition to be studied is the presence or absence of the leiden mutation of the factor v gene.


Eligibility criteria:
inclusion criteria: * women undergoing in-vitro fertilization with successful ovarian hyperstimulation, oocyte retrieval, and fertilization * transfer of at least 2 fresh embryos of grade 2 (preembryo with blastomeres of equal size and \<=10% cytoplasmic fragmentation) or better exclusion criteria: * infertility due to uterine anatomic defect * current use of anticoagulant medication, such as heparin or aspirin * known presence of any other condition associated with increased risk of thrombosis

Keywords: infertility factor v leiden
combined compared to sequential cognitive and physical training in anterior cruciate ligament reconstructed individuals

Conditions: Anterior Cruciate Ligament Reconstruction Rehabilitation

Summary: the goal of this clinical trial is to investigate changes in cognitive and physical performance after 10 weeks of dual or single task training in anterior cruciate ligament (acl) reconstructed individuals. the main questions it aims to answer are: * does cognitive performance in acl reconstructed individuals change after multiple training sessions incorporating single versus dual-task? * does physical performance and intrinsic motivation for training change over the course of 10 weeks when performing single versus dual-task training sessions? * what movement patterns do acl reconstructed individuals show during a dual-task training in an immersive environment? researchers will compare a combined dual-task training (combined physical and cognitive training) to a single task training (physical and cognitive training separately) to see if there are changes on cognitive performance depending on the training type. participants will: * perform dual-task or single task training twice per week for 10 weeks * visit the clinic before and after the training period for tests * visit the movement laboratory once for analysis of movement patterns


Eligibility criteria:
inclusion criteria: * 18-40 years old * at least 6 months after acl injury * surgically reconstructed acl * at least 2 hours of sports participation before the injury * written consent of the attending surgeon to perform intensified training methods including one-legged jumps at 6 months after surgery after the first visit * ability to give informed consent as documented by signature * ability to understand instructions in german or english * bmi \< 28 kg/m\^2 * availability to take part in at least 70% of all training sessions exclusion criteria: * surgery on the contralateral leg during the last 12 months * acute or chronic musculoskeletal, neurological, or cardiopulmonary disorders * unadjusted vision problems * concussion during the last 6 months * pregnancy * breastfeeding * amputation * inflammatory pain or swelling during exercising

Keywords: motor-cognitive training dual-task training anterior cruciate ligament injury return to competition
a lithium-containing mouthwash prevention and treatment of oral mucositis and dysgeusia in patients undergoing radiotherapy

Conditions: Head and Neck Squamous Cell Carcinoma; Malignant Head and Neck Tumors

Summary: to evaluate the efficacy and safety of lithium-containing mouthwash for prevention and treatment of oral mucositis and dysgeusia in patients undergoing radiotherapy for malignant head and neck tumors.

the goal of this clinical trial is to evaluate the efficacy and safety of lithium-containing mouthwash in reducing the incidence, duration, and severity of severe oral mucositis (som) , and the incidence of dysgeusia. the main questions it aims to answer are whether lithium-containing mouthwash can effectively prevent and treat radiation-induced oral mucositis and dysgeusia, and whether it will cause adverse events in patients undergoing radiotherapy. participants will be instructed to use lithium-containing mouthwash or placebo mouthwash three times daily from the beginning to the end of rt. researchers will compare lithium-containing mouthwash group and placebo group to see if lithium-containing mouthwash are beneficial in preventing and treating oral mucositis and dysgeusia in patients undergoing radiotherapy.

Eligibility criteria:
inclusion criteria: patients pathologically diagnosed with non-metastatic head and neck malignant tumors; aged 18-80 years; eastern cooperative oncology group performance status of ≤2; planning to receive definitive rt or postoperative adjuvant rt; normal liver, kidney and bone marrow function; sign informed consent. exclusion criteria: known to be allergic to lithium or other components of mouthwash or severe allergic constitution; poor oral hygiene and/or severe periodontal diseases; any previous rt to the head and neck region, severe kidney disease, severe cardiovascular disease, myasthenia gravis, parkinson's disease or epilepsy; recent use or current use of diuretics or other drugs known to interact with lithium; deemed unsuitable for the study by the investigators (concomitant with any other severe diseases).

Keywords: head and neck squamous cell carcinoma nasopharyngeal carcinoma malignant head and neck tumors oral mucositis lithium-containing mouthwash
effect of branched-chain amino acid supplementation and exercise on muscle quantity and quality in cirrhosis

Conditions: Muscle Atrophy

Summary: introduction: ultrasound can be used to monitor muscle mass during interventional approaches in patients with liver cirrhosis. the aim: to investigate the effect of branched-chain amino acid (bcaa) supplementation and/or muscle exercise on ultrasound-measured quadriceps muscle thickness and echo intensity, as well as on muscle strength, performance, and nutritional assessment in patients with cirrhosis. patients \& methods: this is a randomized controlled study that included 220 liver cirrhosis patients with child-pugh b \& c classes. they were randomized into a control group comprising 55 patients who received only the standard care, and interventional groups comprising 165 patients equally distributed into three groups, they received in addition to standard care, bcaa, programmed exercise, or bcaa and programmed exercise respectively. at baseline and after 28 days, all participants were subjected to ultrasound-measured quadriceps muscle thickness and echo intensity, in addition to handgrip strength, short physical performance battery (sppb), anthropometric measures, hematological and biochemical assessment, meld score measurement, nutritional assessment using 7- subjective global assessment score (sga).

this is an open, 4-arm parallel, randomized controlled trial conducted on cirrhotic patients all eligible patients received instructions of standard care that includes standard diet and non-exercise activity thermogenesis (neat), then the patients were randomly assigned in an allocation ratio of approximately 1:1:1:1; group 1= control received the standard care only, and three intervention groups; group 2 received added 10 gm/day branched-chain amino acid (bcaa) (manufactured by dulex lab company). group 3 received added home-based exercise comprising both aerobic and resistance exercises, and finally, group 4 received added both bcaa and home-based exercise. all patients were subjected to the following at the baseline and after 28 days: 1. thorough medical history 2. complete clinical examination including bp, middle upper arm circumference (muc), and body mass index (bmi) using the dry weight. 3. the nutritional status assessment using the 7-point subjective global assessment (sga) score, 4. assessment of their physical fitness using the short physical performance battery test (sppb) score. 5. assessment of muscle strength using handgrip strength using a digital dynamometer (model: 12-0286). 6. routine labs including complete blood count (cbc), liver function, kidney function, and electrolytes, fbg 7. calculation of child-pugh \& meld scores. 8. ultrasound assessment of quadriceps muscle thickness and echogenicity

Eligibility criteria:
inclusion criteria: * cirrhotic patients with moderate and marked liver impairment exclusion criteria: * cirrhotic patients with child-pugh class a, patients with acute liver cell failure or malignancies, associated other end-organ failure, and vitally unstable patients.
cortisol in the treatment of phobias

Conditions: Phobia

Summary: the aim of this prospective, double-blind, placebo-controlled, randomized study is to investigate if glucocorticoid treatment, in combination with exposure therapy, helps to reduce phobic fear in patients with phobia.


Eligibility criteria:
inclusion criteria: - female and male patients with a specific phobia (fear of heights) according to dsm-iv criteria. exclusion criteria: * severe acute or chronic somatic diseases * psychiatric disorder other than specific phobia * topic glucocorticoid therapy (for large skin parts) * inhaled glucocorticoids * psychotropic medication * pregnancy

Keywords: phobia cortisol memory treatment
survival impact of internal mammary or supraclavicular lymphadenectomy

Conditions: Ovarian Cancer Stage IV; Lymph Node Metastases

Summary: to evaluate the survival impact of extensive lymphadenectomy as part of debulking surgery in stage ivb ovarian cancer with supradiaphragmatic lymph node metastasis.


Eligibility criteria:
inclusion criteria: * histologically diagnosed ovarian, fallopian tubal, primary peritoneal cancer * patients suspected of metastatic lymph nodes in the cardiophrenic, internal mammary, and/or supraclavicular lymph node by ct (size larger than 5mm) * patients clinically diagnosed figo stage ivb ovarian, fallopian tubal, primary peritoneal cancer * patients underwent debulking surgery (primary debulking surgery or interval debulking surgery) at seoul national university hospital from january 2010 to january 2020 * patients age 18-90 exclusion criteria: * borderline or benign ovarian disease * patient didn't undergo debulking surgery * non-epithelial ovarian cancer

Keywords: internal mammary lymph node supraclavicular lymph node cardiophrenic lymph node
preoperative sleep disorders and postoperative delirium in children undergoing congenital heart surgery

Conditions: Delirium - Postoperative; Sleep Problems; Congenital Heart Disease (CHD)

Summary: the investigators are going to conduct a prospective observational cohort study in pediatric patients aged 28 days to 14 years old scheduled for elective cardiac surgery with cardiopulmonary bypass. the primary purpose of this study is to explore the effect of preoperative sleep disturbance on the incidence of postoperative delirium. sleep status will be assessed using the brief infant sleep questionnaire(bisq) and children's sleep habits questionnaire (cshq), and postoperative delirium status will be evaluated by cornell assessment of pediatric delirium(capd). during the peri-operative period, children will wear actigraphs to record their sleep parameters.


Eligibility criteria:
inclusion criteria: * aged more than 28 days and less than 14 years old； * scheduled to undergo elective corrective surgery for congenital heart disease under cardiopulmonary bypass. exclusion criteria: * emergency surgery; * combined with severe hepatic and renal dysfunction (with a diagnosis of acute or chronic renal insufficiency or requiring renal replacement therapy; with a diagnosis of acute or chronic hepatic insufficiency or requiring artificial liver treatment); * combined with non-cardiac malformations (adenoidal hypertrophy, tracheobronchial stenosis and ocular disorders); * history of preoperative cerebral ischemia or haemorrhage; * refuse to sign the informed consent form or the child has poor compliance.
topical capsaicin for cyclical vomiting

Conditions: Cyclical Vomiting

Summary: this is a phase 2 randomized controlled trial testing the effect of topical capsaicin for the relieve of nausea and vomiting.


Eligibility criteria:
inclusion criteria: * suspected cyclical vomiting syndrome / cannabinoid hyperemesis * active severe nausea or vomiting in the emergency department exclusion criteria: * pregnant women, children \< 18 years, no prior history of similar symptoms, suspected surgical or infectious cause of symptoms, suspected hepatitis or pancreatitis, allergy to capsaicin or hot peppers, chronic use of prescription antiemetic in prior 24 hours, abdominal pain alone (without nausea or vomiting)