Kornimate/medical-research-clean huggingface dataset:
neuromuscular electrical stimulation and septic shock

Conditions: Shock, Septic

Summary: the study will investigate the effects of neuromuscular electrical stimulation (nmes) in patients with septic shock. the objective of this study will be investigate the effects of neuromuscular electrical stimulation (nmes) in patients with septic shock.

the study will investigate the effects of neuromuscular electrical stimulation (nmes) in patients with septic shock. it will be a randomised crossover clinical trial. thirty-one patients will enrolled.the study will be divided in two phases, the first will be held in the first 72 hours of septic shock and the second after three days of first assessment. patients will be selected, randomly, to the intervention protocol (nmes) and control (positioning). after this procedure the patients will be allocated in group 1 (nmes and control) or group 2 (control and nmes), with a wash-out period of 4 to 6 hours in between . the main outcome will be the study of mobilization of endothelial progenitor cells (epcs). the secondary outcome will be the metabolic and hemodynamic data. linear mixed model will be used for analysis of dependent variables and estimated values of the mean of the differences of each effect. the results of this study will allow better understanding of the effects of nmes in patients with septic shock.

Eligibility criteria:
inclusion criteria:the patients admitted to the intensive care unit will be considered eligible if: * they present in the first 72 hours the diagnosis of septic shock according to the international consensus definition of septic shock, and * stable hemodynamics through fluid resuscitation, and * vasoactive drugs and mechanical ventilation. exclusion criteria:the exclusion criteria will be patients aged less than 18 years and greater than 65 years, pregnant women, brain death, neuromuscular diseases, use of pre-existing neuromuscular blocker in the last 24 hours, prior to the study protocol. * contraindications for the use of nmes: fractures, burns and skin lesions, systemic vascular impairment diseases such as systemic lupus erythematosus, thromboembolic disease, deep vein thrombosis (which was not therapeutically anticoagulated for a time greater than 36 hours), lower limb amputations, cardiac pacemaker, thrombocytopenia less than 20,000/mm3, bmi greater than 35 kg/m2, important lower extremity oedema, agitation and/or signs of pain during the electrical stimulation. * contraindications to begin or continue nmes procedure: mean arterial blood pressure less than 65 mmhg, use of vasopressor \>50% of the maximum dose (dopamine \>12.5 µg/kg per minute; vasopressin \>0.02u/min and norepinephrine \>1 µg/kg per minute), heart rate \ 140 bpm, arrhythmias with hemodynamic consequences, myocardial ischemia, temperature \ 39oc, intracranial pressure \>20 cmh2o, decrease in 10% of spo2 baseline value or \<88% for more than one minute.

Keywords: electric stimulation therapy; endothelial progenitor cells.
biomarkers in the nose, throat, and lung tissue of smokers and non-smokers

Conditions: Lung Cancer; Precancerous Condition

Summary: rationale: studying samples of tissue from smokers and non-smokers in the laboratory may help doctors identify and learn more about biomarkers related to cancer. purpose: this phase ii study is looking at biomarkers in the nose, throat, and lung tissue of smokers and non-smokers.

objectives: primary * define the molecular and biochemical profiles of airway epithelium of smokers with no disease, smokers with airflow obstruction and abnormal sputum cytology, and non-smokers. secondary * assess the occurrence of abnormalities in non-smokers, smokers with no disease, smokers with various grades of dysplasia, and smokers with lung cancer. outline: patients are stratified according to smoking status (smoker vs non-smoker) and disease (no disease vs airflow obstruction and abnormal sputum cytology vs various grades of dysplasia vs lung cancer). biological samples are collected and analyzed for future research studies. projected accrual: a total of 78 patients will be accrued for this study.

Eligibility criteria:
inclusion criteria: 1. - adults \> 45 years of age, to be age matched with a previously enrolled cohort of current and ex-smokers with airflow obstruction and moderate atypia on sputum cytology, to be included in the following groups. 2. - non-smoking (less than 100 cigarettes per lifetime) controls \>50 years of age, to be age matched with a previously enrolled cohort with airflow obstruction (fev1 \< 75% predicted and fev1/fvc \< 75%) and moderate atypia on sputum cytology. 3. - current smokers with \> 30 pack years, no airflow obstruction (fev1 \> 90% predicted) or lung cancer, \>50 years of age, to be age matched with a previously enrolled cohort with airflow obstruction and moderate atypia on sputum cytology . 4. - no prior history of a head and neck or bronchogenic carcinoma. 5. - patients must be fully informed of the investigational nature of this study and must sign an informed consent in accordance with institutional and fda guidelines. exclusion criteria: 1. - clinically apparent bleeding diathesis. 2. - cardiac dysrhythmia that is potentially life-threatening, such as ventricular tachycardia, multifocal premature ventricular contractions or supraventricular tachycardias with a rapid ventricular response. well-controlled atrial fibrillation or rare (\< 2/minute) premature ventricular contractions are not exclusionary. 3. - hypoxemia (less than 90% saturation with supplemental oxygen) during bronchoscopy. 4. - evidence of clinically active coronary artery disease, including myocardial infarction within 6 weeks, chest pain, or poorly controlled congestive heart failure, or any other serious medical condition which would preclude a patient from undergoing a bronchoscopy. 5. - acute bronchitis or pneumonia within 8 weeks. 6. - inability to give informed consent. 7. - current smokers with no airflow obstruction may not have a history of coughing more than two times /week.

Keywords: non-small cell lung cancer small cell lung cancer squamous lung dysplasia
to evaluate newly developed pictogram cards and their utility in improving inhaler techniques in asthmatic patients

Conditions: Asthma

Summary: to evaluate newly developed pictogram cards and their utility in improving inhaler techniques in asthmatic patients.

a prospective, open-label, randomized controlled clinical study. for this purpose, pictogram cards are designed for metered dose inhalers (mdi) and dry powder inhalers (dpi). the pictogram labels are designed and printed in colors with urdu language and then attached to the inhaler devices as cards. the demographic, clinical, and medical data are collected from the patients and their medical files. moreover, the different clinical measures are also evaluated in the recruited patients.

Eligibility criteria:
inclusion criteria: * asthmatic patients, should take inhalers regularly for at least 3 months and come personally for re-fill. exclusion criteria: * coexistence of other chronic respiratory conditions. * those who were difficult to communicate.

Keywords: pictograms mdi dpi inhaler pictogram cards asthma
cabotegravir plus rilpivirine long-acting regimen in the swiss hiv cohort study:uptake, outcome, and risk factors for treatment failures

Conditions: HIV Infections

Summary: this study aims to characterize swiss hiv cohort study participants initiating the cab+rpv la regimen, assess adherence to swiss label indications, and describe treatment outcomes in this large, multicentre, heterogeneous, high-income setting. moreover, the study aims to assess virological, immunological, demographic, clinical, and behavioural factors associated with viral failure under cab+rpv la regimen.


Eligibility criteria:
inclusion criteria: * participant in the shcs * all shcs participants initiating the cab+rpv la regimen * all shcs participants on soc oral regimen exclusion criteria: * not participating in the shcs
the palliative radiotherapy and inflammation study - prais

Conditions: Neoplasm Metastasis; Bone Neoplasms

Summary: radiation therapy (rt) is one of the primary treatments for bone cancer pain due to metastatic cancer disease. about 6 of 10 patients obtain pain relief from rt. there are no established predictors that can be used to select patients that respond to rt. this raises the need to identify potential clinical characteristics and biomarkers that may better select patients for rt. a similar argument can be stated for the development of cachexia; there are currently no predictors that can identify patients who will develop cachexia later in the cancer disease trajectory. cancer symptoms can be related to inflammation. both pain, cachexia and depression are associated with inflammation in experimental and preclinical studies . still, the clinical data on the relationship between inflammation and pain or cachexia are sparse. this is especially true for longitudinal follow-up studies. this study will include 1000 adult patients in a multicenter, multinational longitudinal observation study of patients who receive radiation therapy for bone cancer pain. demographic data, clinical variables, genetic biomarkers and inflammatory substances will be assessed before start of rt. the primary analysis in the study is to identify potential predictors for pain relief from rt. during follow up the study will also explore for predictors for development of cachexia and which inflammatory substances that are associated with changes in pain intensity, depression and development of cachexia.


Eligibility criteria:
inclusion criteria: * verified cancer diagnosis (based on radiological, histological, cytological or operative evidence). those with hematological malignancies are also eligible. * bone metastasis verified either by bone x-ray, bone scan, computer tomography (ct) or magnetic resonance imaging (mri) * patients that are about to undergo radiotherapy with palliative intent for painful bone metastasis * radiotherapy should be administered within one week after baseline observations are obtained * age ≥18 years * patient is able to comply with trial procedures. exclusion criteria: * pathological fracture in long bones (e.g femora or humeral shaft fractures) * patients not consenting to participate in the study * on-going rt or rt administered within the last 4 weeks * patients who are not able to follow the trial procedures * previous participation in this study

Keywords: radiotherapy cachexia inflammation depression
accuracy of pulse oximeters with profound hypoxia at rest (niho18)

Conditions: Hypoxia

Summary: the aim of this study is to determine the accuracy of devices called pulse oximeters, which measure blood oxygen by shining light through fingers, ears or other skin, without requiring blood sampling. study will be used with patients at rest.

this study is intended to evaluate performance of a new design pulse oximeter (test device) manufactured by nihon kohden corporation sufficiently to support performance claims for an fda 510k submission or iso technical file. specifically, spo2 and pulse rate accuracy will be assessed for a nihon kohden olv-4202 pulse oximeter with adult patients under a controlled setting of varying levels of inhaled oxygen concentration levels for patients at rest.

Eligibility criteria:
inclusion criteria: * both male and female subjects who can give written informed consent * healthy subjects capable of undergoing controlled hypoxemia to the levels outlined in the desaturation profile * meeting the demographic requirements exclusion criteria: * age below 18 or over 50 * pregnant women * significant arrhythmia * blood pressure above 150 systolic or 90 diastolic * carboxyhemoglobin levels over 3% * subjects whom the investigator consider ineligible for the study
treatment rates and compliance to treatment in patients with familial hypercholesterolemia

Conditions: Familial Hypercholesterolemia

Summary: familial hypercholesterolemia is a genetic disease characterized by increased levels of low density lipoprotein cholesterol (ldl-c). it is underdiagnosed and undertreated despite relatively high prevalence and significant association with increased mortality.

patients older than 18 years old and have a serum low density ldl-c≥250 mg/dl were identified from the hospital database. a questionnaire was completed via phone. patients were classified as definite, probable and possible familial hypercholesterolemia according to dutch lipid clinical network criteria

Eligibility criteria:
inclusion criteria: * patients older than 18 years old and have a serum ldl-c≥250 mg/dl exclusion criteria: * patients who refuse dto interview * serum tsh≥10 miu/ml * glomerulonephritis or nephrotic syndrome * alt or ast higher than 3 times of normal limits * serum triglyceride \>400 mg/dl
exibit: oxaliplatin in biliary tract cancer

Conditions: Biliary Tract Neoplasms

Summary: the primary objective is to evaluate the efficacy of the gemox treatment as 1st line therapy in patients with advanced biliary tract cancer based on response rate measured by the recist unidimensional criteria. secondary objectives are : progression free survival, overall survival and safety.


Eligibility criteria:
* histologically proven, locally advanced or metastatic carcinoma of the biliary tract (gallbladder, intrahepatic bile ducts, extrahepatic bile ducts, ampula of vater) * for intrahepatic bile ducts, if the diagnosis of biliary tract origin is not evident by imaging or surgical exploration, and so equivalent to liver metastasis with unknown primary site, inclusion is possible if: * unknown primary after an exhaustive search for the primary site (chest radiography- , thoracic and abdomino pelvic ct scan, colonoscopy, oesogastroduodenal endoscopy, psa determination for men or mammography for women, and pet scan if possible). * histological examination compatible with adenocarcinoma of bile ducts with the immunostaining expression of cytokeratin : 7+, 20- and 19 +. (shimonishi, 2000 \^22) * no prior chemotherapy for advanced disease (first line) * no radiation therapy within 4 weeks prior to the first gemcitabine administration. * unidimensionally measurable disease. * for female patient of childbearing potential, neither pregnant nor breastfeeding, and under active contraception * no known allergy to one of the study drugs * no prior malignancy * no cns metastases * no peripheral neuropathy \> grade 2 * ecog ps \<=2 * anc \> 1.5 x 10\^9 /l * platelets \> 100 x 10\^9 /l * creatinine \< 1.5 x uln * sgpt (alt) \< 5 x uln * bilirubin \< 2.5 x uln (patients with jaundice or evidence of bile duct obstruction and in whom the biliary tree can be decompressed by endoscopic percutaneous endoprothesis, with subsequent reduction in bilirubin \< 2.5 x uln will be eligible for the study).
diaphragmatic breathing as an adjunctive therapy in the management of children with bladder and bowel disorders

Conditions: Bladder and Bowel Disorder, Pediatric

Summary: urination is a result of a complex neuro-muscular coordination which involves the action and arrangement of different parts of nervous systems as well as the muscular structure of the lower part of the urinary system. when there is an abnormal pattern in bladder and bowel habits without any known neuronal lesions, the condition is called bladder and bowel disorder (bbd). the symptoms can range from the feeling of rushing to the toilet, urinary accidents to urinating much less than expected during the day. the standard treatment for most cases of bbd starts with standard urotherapy (su) which is a beneficial basic and harmless form of treatment widely used for all children with bbd. su involves explaining of the problem to the children and their parents by the doctors and educating them on proper voiding mechanisms, sitting, and standing positions as well as how and when to void. the purpose of this study is to explore the possibility of testing the additive effectiveness of diaphragmatic breathing exercise (db) as an alternative and harmless additional treatment to su in children with bbd.


Eligibility criteria:
inclusion criteria: 1. children with bladder and bowel disorders (bbd) will be diagnosed by the attending pediatric urologists via a combination of thorough clinical history, physical examination, bbd questionnaire, uroflowmetric evaluation, and voiding and stool diary. exclusion criteria: 1. known anatomic or neurological lower urinary tract abnormalities such as posterior urethral valve, urethral obstruction or stricture, ectopic ureters, congenital abnormalities of the spinal cord, or any previous surgery of the lower urinary tract. 2. current use of medication or treatments which affects bladder or ans function. these include anti-cholinergics, anti-psychotics, anti-depressants, and neuromodulators. 3. any conditions or disorders that would affect the cardiovascular system or the activity of the ans. 4. serious pulmonary issues or diaphragmatic problems that would interfere with the practice of diaphragmatic breathing technique. 5. psychological/behavioral abnormalities severe enough to prevent the cooperation of the child with the study coordinator or the urologist. 6. inability to provide consent. 7. inability to speak and/or understand in english.

Keywords: diaphragmatic breathing (db) bladder and bowel disorders (bbd) autonomic nervous system (ans) heart rate variability (hrv) deep breathing randomized controlled trial (rct)
building blocks for healthy preschoolers

Conditions: Pediatric Obesity

Summary: pediatric obesity, a defining health problem of the century, leads to long-term health disparities. this application evaluates strategies to prevent health disparities early in life by developing environmental wellness-related interventions focused on child-care center staff and families. childcare centers provide an excellent opportunity to build healthy dietary and physical activity lifestyle habits and avoid the rapid weight gain that leads to health disparities. building on a statewide survey among childcare centers and a pilot evaluation of an environmental intervention, this 3-cell randomized trial evaluates the impact of a staff-led wellness intervention and a staff-led and family-focused intervention, against a control condition.

the intervention trial will be conducted in 48-55 childcare centers throughout maryland, enrolling 864 children age 30-54 months from childcare centers serving low-income families. the aims are: 1. to examine the impact of the wellness intervention individually and combined with the family intervention versus control on bmi z-score, food preferences and knowledge, and physical activity among children 2. to examine the sustainability of the interventions 3. to examine whether changes in outcomes measures for children's bmi z-score, gross motor skills, food preferences and knowledge, and physical activity are mediated by changes in the childcare staff wellness-related attitudes and behaviors and/or parent wellness-related attitudes and behaviors (exploratory). findings from the trial will inform programs and policies in childcare centers to prevent obesity and reduce disparities, and will be disseminated locally, regionally, and nationally through conferences, information briefs, social media, and peer-reviewed journal articles. the overall objective is to promote statewide strategies that reduce pediatric obesity and the long-term health disparities.

Eligibility criteria:
inclusion criteria: * preschooler 30-54 months * caregiver and childcare staff must be at least 18 years old * childcare center staff members willing to participate * licensed childcare centers serving low-income communities * children attending participating childcare centers (at least 3 days per week) exclusion criteria: * caregivers and staff who do not speak or read english * childcare staff and preschoolers with health problems that would interfere with participation in physical activities

Keywords: overweight obesity prevention children childcare physical activity nutrition wellness environment intervention feeding
radiation treatment of lymph node recurrence from prostate cancer : is 11c-choline pet/ct predictive of survival outcomes?

Conditions: Prostate Cancer

Summary: the role of pet/ct with choline in the restaging of prostatic disease is now universally recognized, and its use has become routine in numerous centers in italy and abroad. the indication for the test is provided exclusively by an increase in psa. it was interesting to understand whether these prognostic factors have an influence on the probability of detecting disease by pet with choline to identify patients who have a greater probability of benefiting from the use of this method with the possibility of identifying the disease in earlier stages.


Eligibility criteria:
inclusion criteria: * patients operated with radical prostatectomy * patients that present biochemical recurrence of the disease; exclusion criteria: * patients \<18 years
home-based exercise training in older adults during the covid-19 pandemic

Conditions: Physical Inactivity; Aging; COVID-19 Pandemic

Summary: the physical fitness and functionality of older adults are affected during the covid-19 pandemic. regular exercise programs are effective in physical fitness and functioning in older adults. individualized and supervised exercise programs for older adults in a safe environment can improve physical fitness and functionality. this study aims to examine the effect of home-based and exercise training on physical fitness and functionality in sedentary older adults during the covid-19 pandemic.

purpose: this study aims to examine the effect of home-based supervised exercise programs on physical fitness and functionality in sedentary older adults during the covid-19 pandemic. methods: the older adults participating in the study are divided into two groups as exercise group and the control group. individual exercise training is applied to the exercise group for eight weeks, three days a week, and 45 minutes a day. this exercise training consists of a program that includes strengthening, flexibility, aerobic, and balance exercises. the control group is given only of stretching and breathing exercises. individuals are evaluated using the berg balance scale, timed up and go test, senior fitness test, and tinetti falling efficacy scale before starting the study and at the end of the eight weeks.

Eligibility criteria:
inclusion criteria: 1. individuals aged between 65-85 years 2. individuals have 24 points and above from the standardized mini-mental state examination 3. sedentary individuals whose physical activity levels are inactive or minimally active group according to the short form of international physical activity questionnaire (ipaq-sf). 4. individuals who can stand for at least 90 seconds without assistance 5. individuals who voluntarily agree to participate in the study 6. individuals who have not suffered from covid infection. exclusion criteria: 1. individuals who have malignancy 2. individuals who are ambulatory with assistance 3. individuals who have severe vision loss 4. individuals who have a neurological disease (stroke, parkinson, multiple sclerosis) 5. individuals who had surgery in the last six months 6. individuals who have congestive heart failure 7. individuals who have received exercise training in the last six months

Keywords: exercise physical fitness functionality older adults