Kornimate/medical-research-clean huggingface dataset:
tryptase and coronary heart disease

Conditions: Acute Coronary Syndrome With ST Elevation on Electrocardiogram; Acute Coronary Syndrome Without ST Elevation on Electrocardiogram; Noncritical Coronary Artery Disease Coronary Stenosis Less Than 50 Per Cent; Aortic Aneurysms

Summary: the main aim of this study will evaluate differences in serum levels of tryptase in study population. will be selected a number of 350 patients hospitalized for coronary heart disease.

a series of scientific studies have evaluated the tryptase as a biomarker of coronary plaque instability, in the course of ischemic heart disease. among these, the most recent and 'outcome' is better defined by meixiang xiang study, which has been conducted in 2011 on 270 patients. this study evaluated and compared the levels of tryptase in four populations: 1. acute myocardial infarction (31 subjects) 2. unstable angina (108 subjects) 3. stable angina (36 subjects) 4. coronary artery disease with coronary stenosis \<50% (95 subjects). in this chinese population the final evaluations have led to define the tryptase as a marker independent of instability of the atheromatous plaque. in reference to the fact that there is still some correlation between tryptase and coronary plaque instability and clinical symptoms, we propose a verification study of the role of tryptase as a biomarker in acute coronary conditions by studying a large population of italian subjects in the acute phase of pathology and follow up. the work will be conducted on 4 patient population: 1. acute coronary syndrome with st elevation on electrocardiogram; 2. acute coronary syndrome without st elevation on electrocardiogram (acute myocardial infarction with st-segment depression on electrocardiogram and unstable angina) 3. noncritical coronary artery disease with coronary stenosis \<50%; 4. aortic aneurysms. secondary endpoints will evaluate the role of tryptase in the event of major cardiovascular events.

Eligibility criteria:
inclusion criteria: * male and female subjects aged 18 to 80 years * patients with clinical manifestations have been discovered and documented symptoms of coronary heart disease * all patients with these characteristics will necessarily have to sign the informed consent for inclusion in the study exclusion criteria: * patients with allergy symptoms in place (hives, uncontrolled asthma) autoimmune diseases, mastocytosis, hypereosinophilia, myelodysplastic syndrome, cancer, kidney failure * those who deny consent to participate

Keywords: tryptase coronary stemi nstemi
(easy)-improving adherence to clopidogrel trial (impact))

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to test the impact of a multidisciplinary approach to improve the adhesion and persistence to clopidogrel therapy. a simple and inexpensive therapy management involving a tighter monitoring of patients by nurses and pharmacists will improve the persistence and adhesion to clopidogrel and aspirin after the implantation of drug-eluting stents.

optimal treatment with clopidogrel and aspirin is critical for preventing complications after implantation of drug-eluting stents (des). the premature cessation of clopidogrel is a well recognized factor of thrombosis of stents, especially des. indeed, there remains a large portion of patients that prematurely stop clopidogrel. no study has demonstrated that a therapeutic management program could improve patient compliance to their antiplatelets. through an open-label clinical study, two groups of patients who just received their des will be compared: one with the usual protocol (consisting of seeing the cardiologist 6 weeks after the intervention) and one with the normal care supplemented by a simple and efficient follow-up (consisting of phone calls at 7 days, 1 month, 6 months and 9 months explaining the importance of antiplatelet therapy, evaluating the health of the patient and well received prescription from the pharmacy). patients in both groups will receive a prescription to clopidogrel and aspirin (for 1 month), with 11 renewals.

Eligibility criteria:
inclusion criteria: * percutaneous coronary intervention with implantation of drug-eluting stent * prescription for plavix and aspirin exclusion criteria: * patients frequenting more than one pharmacy

Keywords: drug eluting stent clopidogrel aspirin
clinical study on the use of massage to reconstruct the function of lumbar stabilizer muscles and improve the "muscle and bone imbalance" of lumbar disc herniation

Conditions: Lumbar Disc Herniation

Summary: 1. .characterization of stabilizing muscle dysfunction in ldh patients using advanced techniques such as high-density surface electromyography (hd-semg), this study will investigate the functional imbalance of lumbar stabilizing muscles in ldh patients by comparing their muscle function indicators to those of healthy controls. 2. .impact of spinal manipulation on lumbar stabilizing muscle function through serial semg evaluations, the study will assess changes in stabilizing muscle function in ldh patients before and after spinal manipulation. this includes a focus on endurance, motor control, and reaction time, providing evidence to inform the application of spinal manipulation in ldh treatment. 3. .exploration of mechanisms underlying spinal manipulation in improving "musculoskeletal imbalance" the study will examine correlations between improvements in stabilizing muscle function and clinical symptoms, such as pain relief and functional recovery. statistical analyses of semg data and clinical efficacy indicators will be conducted to uncover the therapeutic characteristics of spinal manipulation in ldh intervention, offering new theoretical bases and strategies for long-term treatment and recurrence prevention.


Eligibility criteria:
inclusion criteria: * 1.meet the diagnostic criteria for ldh as outlined in the ninth edition of "surgery," with confirmation via mri; * 2.age between 20 and 50; * 3.simple l4/5 disc herniation; vas score ≥30/100; * 4.lumbar odi index ≥20; * 5.no massage, acupuncture, or physical therapy within the past month; * 6.signed informed consent form. exclusion criteria: * 1: exclusion criteria: history of spinal surgery or severe spinal trauma; * 2: combined with bone tuberculosis, tumors, severe osteoporosis, etc; * 3: combined with serious internal diseases such as cardiovascular, hematological, digestive system diseases, or psychiatric disorders; * 4: pregnant or lactating women; * 5: combined with autoimmune diseases, allergic diseases, acute or chronic infectious diseases accompanied by pain and joint dysfunction; * 6: mri showing free nucleus pulposus or accompanied by cauda equina syndrome.
reducing alcohol use in depressed patients

Conditions: Depression; Alcohol Use

Summary: the purpose of this study is to determine whether a brief alcohol intervention reduces alcohol use and improves depression among depressed patients.

heavy alcohol consumption is common among patients seeking treatment for depression. heavy drinking is associated with a variety of medical and psychosocial problems. heavy drinking is particularly problematic among depressed patients, increasing the likelihood of poor depression treatment outcomes. while methods for reducing alcohol use in this population have been unexplored to date, brief interventions to reduce heavy alcohol use have been well-validated in numerous patient populations and offer the promise to reduce heavy drinking among depressed patients and to improve depression treatment outcomes. we hypothesize that adding a brief alcohol intervention to standard psychiatric care, relative to standard psychiatric care alone, will reduce overall drinking volume and heavy drinking days among heavy-drinking depressed patients. furthermore, we expect patients who receive the brief alcohol intervention to have better depression outcomes than patients receiving standard psychiatric care alone. we also expect that reduced alcohol consumption will mediate the effect of the brief alcohol intervention on depression outcomes. in addition, we will examine individual difference variables as predictors of change in alcohol use. the proposed study is a randomized, two-group design with repeated measures over time, comparing a brief, motivationally-focused alcohol intervention plus standard psychiatric care to standard psychiatric care alone. for this study, we will recruit a sample of 240 psychiatry clinic outpatients meeting structured diagnostic criteria for major depressive disorder who drink heavily but are not alcohol dependent. we expect that the results of this study will improve depression treatment outcomes for the significant subpopulation of depression patients who drink heavily and are likely to do poorly in depression treatment in the absence of a change in their drinking behavior. the intervention proposed in this study represents a novel approach to reducing heavy drinking among depressed patients that, if effective, can be readily integrated into depression treatment in a variety of treatment settings. in addition, this study will provide valuable information on the association between alcohol use and depression outcomes and on the mechanisms of change in alcohol use among heavy-drinking depressed patients.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * meet criteria for current major depressive disorder * have consumed more than 14 drinks per week or more than 5 drinks on one occasion in the past month for men or more than 7 drinks per week or more than 4 drinks on one occasion in the past month for females exclusion criteria: * meet criteria for current alcohol dependence or current psychoactive substance dependence (excluding nicotine) * currently psychotic

Keywords: depression alcohol use motivational interviewing
spine quantitative computed tomography (qct)

Conditions: Juvenile Idiopathic Arthritis

Summary: the purpose of this study is to compare healthy children to children who have a chronic illness called juvenile idiopathic arthritis (jia). jia is a childhood disease that causes swollen joints that are often stiff and painful. jia affects about 1 in 1,000 children age 16 and younger.

children with chronic illnesses are at risk for bone fragility due to inflammation, glucocorticoid therapy, physical activity limitation, malnutrition, and pubertal delay. the impact of low bone mass during childhood may be immediate, resulting in childhood fractures, or delayed, due to suboptimal peak bone mass attainment.

Eligibility criteria:
inclusion criteria: * for jia patients: subjects age 5-21 drawn from dr. burnham's prospective cohort study of bone health in 101 children with arthritis. * for control patients: subjects age 5-21 controls will be a 50% male/female exclusion criteria: * for jia patients: subjects with jia will be excluded if they have conditions or drug exposure unrelated to jia and known to impact growth or bone health. * for control patients: chronic disease or syndrome known to affect growth or bone health, prematurity (\<37 weeks gestation), or use of any medication known to affect growth.

Keywords: juvenile idiopathic arthritis jia arthritis osteoporosis osteoporosis in children
stress response in opioid use disorder

Conditions: Opioid-use Disorder

Summary: opioid use disorder is a major public health problem. although there are effective treatments for this disorder, many people still relapse and thus there is a need for new treatments to improve outcomes. people who have a strong emotional and physical response to stress are at a higher risk of relapse. the goal of this project is to test the effect of strategies to reduce response to stress in people diagnosed with opioid use disorder. men and women diagnosed with opioid use disorder will be recruited for a one-session study. participants will be randomly assigned to one of three brief instructional conditions followed by a brief laboratory stress test. investigators hypothesize that, compared to education about stress, brief strategies to help people cope with negative emotions will reduce responses to stress and increase tolerance of stress. if this hypothesis is supported, it will inform the development of new treatments to improve outcome in opioid use disorder.


Eligibility criteria:
inclusion criteria: * 18 years or older * primary diagnosis of opioid use disorder * ability to read and provide informed consent exclusion criteria: * major psychiatric or medical condition that would interfere with the ability to complete study procedures * current opioid withdrawal * presence of another current substance use disorder at a severity requiring acute treatment * endocrine disease or current steroid prescription * opioid-positive urine drug screen or breath alcohol test on the data or enrollment (not including prescribed medications)
breastfeeding rates at the department of neonatology of university hospital cologne

Conditions: Newborn

Summary: the objective of this study is to measure the breastfeeding success for all preterm and term newborns in our department of neonatology during the hospital stay and at the age of six months.

a score was established which combines information on breastfeeding rate and breastmilk feeding rate, and used to monitor daily breastfeeding success.

Eligibility criteria:
inclusion criteria: * inborn or referred to our department of neonatology in the first week of life * informed consent of both parents or legal guardian exclusion criteria: * no informed consent of parent or legal guardian.

Keywords: breastfeeding rate preterm infant neonatal intensive care unit
evaluation of the cad-det system, a novel non-invasive acoustic diagnostic for the diagnosis of coronary artery disease

Conditions: Coronary Artery Disease; Cardiovascular Disease

Summary: the primary purpose of this multi-center study is to collect and study the acoustic and electrical signals created by the heart during the cardiac cycle as a result of stenosis or plaque associated with coronary artery disease (cad).

this research intends to evaluate acoustic and electrical cardiovascular signals in patients with known or suspected cad and establish the ability of the cad-det system to accurately and reliably detect them utilizing coronary computed tomography (ccta) and invasive coronary angiography (ica) as reference standards. in addition, this study will collect clinical and acoustic data of other cardiac pathologies to better understand their impact on the acoustic signatures associated with cad.

Eligibility criteria:
inclusion criteria: 1. age ≥ 19 years; 2. suspected or known cad; 3. able and willing to comply with the study procedures; 4. referred to ica or ccta for cad characterization; 5. willingness and ability to sign the informed consent form. exclusion criteria: 1. unwillingness or inability to provide informed consent; 2. age less than 19 years; 3. pregnancy; 4. skin injury/diseases/lesions that would preclude safe application of the cad-det device.

Keywords: coronary artery disease cardiovascular disease atherosclerosis coronary occlusion non-invasive medical device cardiac diagnostics
exploring clinical trial experiences of people with leiomyosarcoma

Conditions: Leiomyosarcoma

Summary: clinical study participation has historically been heavily biased toward specific demographics. several people will be invited to enroll in this study so that it may collect a variety of data about leiomyosarcoma clinical trial experiences and identify barriers to participation as well as the causes of participants' failure or withdrawal. people with leiomyosarcoma who are invited to take part in medical research will benefit from the analysis of the data.


Eligibility criteria:
inclusion criteria: * patient has self-identified as planning to enroll in an interventional clinical trial * patient has been diagnosed with leiomyosarcoma * patient is a minimum of 18 years or older exclusion criteria: * patient does not understand, sign, and return consent form * inability to perform regular electronic reporting * patient is pregnant * ecog score of 4

Keywords: leiomyosarcoma
adult spinal muscular atrophy (sma) china registry

Conditions: Muscular Atrophy, Spinal

Summary: the primary objective of the study is to describe the natural history and utilization of disease modifying therapy (dmt) among adult chinese participants with sma linked to chromosome 5q (5q-sma).


Eligibility criteria:
key inclusion criteria: -genetically confirmed 5q-sma. key exclusion criteria: -other types of sma (non 5q-sma). note: other protocol defined inclusion/exclusion criteria may apply
surgical manipulation of the aorta and cerebral infarction

Conditions: Coronary Heart Disease; Stroke; Cerebral Infarction

Summary: the purpose of the study is to compare two surgical strategies for coronary artery bypass grafting with respect to the occurrence of cerebral infarctions made visible by magnetic resonance imaging

stroke is one of the most devastating complications following coronary artery bypass grafting (cabg) with an overall incidence ranging from 2.0 % to 3.2 %. the presumed etiology for the majority of strokes after cabg is atheroembolism from the diseased aorta ascendens caused by surgical manipulation. off-pump coronary artery bypass grafting (opcab) allows the construction of bypass grafts without surgical manipulation of the aorta. yet a trial comparing different surgical strategies with stroke as the primary end point would require several thousand patients to achieve an adequate statistical power. the number of patients can be substantially reduced, if cerebral damage is assessed by diffusion-weighted magnetic resonance imaging (dw-mri). using dw-mri we have recently demonstrated that 25% of a patient population undergoing cabg without an increased risk of stroke showed new cerebral infarctions. these new cerebral lesions all showed an embolic pattern, became visible at t2-weighted images and were clinically silent, e .g. did not cause a new focal neurologic deficit. given the much higher frequency of cerebral lesions assessed by dw-mri than clinically apparent stroke, dw-mri is an ideal surrogate parameter for the assessment of cerebral damage in patients undergoing cabg. the aim of the study is therefore, to investigate the influence of the surgical technique on the occurence of new ischemic cerebral lesions as assessed by dw-mri in patients undergoing cabg in a prospective randomized setting. we hypothesize that opcab, which enables sparing of aortic manipulation, will reduce cerebral infarctions in patients with an increased risk for perioperative stroke.

Eligibility criteria:
inclusion criteria: * age \> 72 * history of stroke * cerebrovascular artery disease with stenosis \> 50% * peripheral arterial disease. exclusion criteria: * urgent or emergency operation * unstable angina * reoperation * concomitant valvular disease requiring surgery * implanted pacemaker or other incorporated ferromagnetic material * claustrophobia.

Keywords: coronary artery bypass off pump coronary artery bypass grafting (opcab)
postmastecomy internal mammary nodal irradiation for high-risk breast cancer patients

Conditions: Breast Cancer

Summary: the purpose of this study is to evaluate the impact of internal mammary nodal irradiation on disease-free survival in high-risk breast cancer patients treated with mastectomy.

eligible patients are randomized into 2 groups: chest wall and supraclavicular nodal +-axillary plus internal mammary nodal irradiation, and chest wall and supraclavicular nodal +-axillary nodal irradiation. the prescription dose is 50 gy in 25 fractions over 5 weeks or 43.5gy in 15 fractions over 3 weeks. during and after radiotherapy, the patients are followed and the efficacy and toxicities of radiotherapy are evaluated.

Eligibility criteria:
inclusion criteria: * eastern cooperative oncology group performance status scale 0-2 * histologically confirmed invasive breast cancer * underwent total mastectomy and axillary dissection(10 or more axillary lymph nodes detected) and negative margins * patients who had ≥4 positive axillary lymph nodes; or 1-3positive axillary lymph nodes and t3-4; or 1-3positive axillary lymph nodes and t1-2, and score≥3 based on the following high risk factors: age≤40 years(score 1), primary tumor in the inner quadrant (score 1), 2-3 positive axillary lymph nodes (score 1), positive vascular invasion (score 1), re-staged based on eighth cancer staging system staging system(ib-iia score 1， iib-iiia score 2); or ypn+ after neoadjuvant chemotherapy * no supraclavicular or internal mammary nodes metastases based on images before system therapy * no distant metastases * could tolerate radiotherapy * treated with chemotherapy (anthracycline and/or taxane-based combined chemotherapy, ≥6 cycles) * anticipated to receive endocrine therapy for 5 years if indicated * anticipated to receive anti-her2 therapy for 1 years if indicated * lvef≥50% based on echocardiogram * willing to follow up * written,informed consent exclusion criteria: * simultaneous bilateral breast cancer * sentinel lymph node biopsy only without axillary dissection * had received internal mammary node dissection * no imaging assessment of the internal mammary nodal before system therapy * one-stage breast reconstruction * severe cardiac insufficiency; myocardial infarction or uncorrected unstable arrhythmia or uncorrected unstable angina in the last 3 months; pericardial disease * had history of chest wall or supraclavicular radiotherapy * had simultaneous or previous secondary malignancies, except for non-malignant melanoma skin cancer, papillary thyroid / follicular carcinoma, cervical carcinoma in situ, contralateral non-invasive breast cancer

Keywords: breast neoplasm mastectomy radiotherapy internal mammary node
a user study of synus pain relief made by tivic health systems

Conditions: Sinus; Inflammation

Summary: demonstrate the ability of subjects suffering from sinus pain to self-treat with the synus pain relief device and to obtain pain relief compared to a sham/placebo device.

a prospective study of at least 58 recruited subjects suffering from sinus pain. at least 30 of the subjects will be randomly selected to use the synus pain relief device, a device that uses micro-currents to stimulate major nerve fibers passing from the sinus passages through various foramina to the facial skin. subjects will read manufacturer's provided instructions-for-use (ifu's) and without help from staff will proceed to self-perform the treatment. the other subjects will follow the same procedure but use a sham/placebo device with no stimulating current. subjects will be blinded as to the device they use. prior to and 10 minutes following the stimulation, subjects will score their pain level on a visual analogue scale.

Eligibility criteria:
inclusion criteria: * be 18 years of age and older * present with symptoms of sinus pain and pressure * have an initial sinus pain score of 4 or more on the visual analogue scale * be able to read and understand english * agree to participate in the study * be able and willing to provide informed consent exclusion criteria: * do not meet inclusion criteria * have currently a dental infection * have currently abnormal cranial nerve or other neurological findings or symptoms that would require prompt medical attention * be currently pregnant * have implanted electrostimulation devices including a pacemaker, a dbs or a cochlear implant