Kornimate/medical-research-clean huggingface dataset:
cardiovascular risk factors after single pancreas transplantation

Conditions: Diabetes Type 1; Endothelial Dysfunction

Summary: patients accepted for the waiting list for single pancreas transplantation suffer from severe glucose instability with hyperglycemia due to diabetes type 1, but do not have significant diabetes-related complications. pancreas transplantation restores normoglycemia in diabetes type 1 patients with unstable control of glycemia. both hypo- and hyperglycemic events are abolished, and 70-80 % of the patients obtain satisfactory hba1c levels (hba1c 5.0-6.0 %) without the need of exogenous insulin. endothelial dysfunction is considered as an early and potentially reversible stage in the atherosclerotic process. the endothelium is involved in homeostasis, leucocyte adhesion and vasomotor activity. reduced endothelium-dependent vasodilation is associated with increments in cardiovascular risk factors, and endothelial dysfunction is a predictor for future cardiovascular disease. it has also been hypothesized that endothelial dysfunction may be involved in the impaired glycemic control by reducing the availability of glucose in peripheral muscles.establishing normoglycemia by pancreas transplantation alone in previously diabetic type 1 patients has recently been shown to improve left ventricular ejection fraction, assessed by doppler echocardiographic examination. in diabetic patients receiving a new pancreas it is possible to assess the effect of changing blood glucose excursions on cardiovascular risk factors, including endothelial function, without the use of antidiabetic drugs (exclude pleiotropic effects). the primary objective of the present study is to assess if endothelial function (assessed by flow-mediated dilatation of arteria brachialis) is improved when hyperglycemia is reversed by single pancreas transplantation in patients with type 1 diabetes. secondary objectives are to investigate the changes in the following parameters by reversal of hyperglycemia by pancreas transplantation; peripheral arterial tonometry, serum/plasma concentrations of endothelial dysfunction markers, blood pressure, lipid and lipoprotein concentrations.


Eligibility criteria:
inclusion criteria: * patients with type 1 diabetes accepted for the waiting list for single pancreas transplantation * healthy volunteers (non-diabetic, non-transplanted) * over 18 years of age * signed informed consent exclusion criteria: * non-functioning pancreas graft (defined as hba1c ≥ 6.5 % with the need of insulin injections and fasting c-peptide concentration \< 300 pmol/l). * active infection * active autoimmune disease other than diabetes * severe liver disease

Keywords: diabetes type 1 endothelial dysfunction pancreas transplantation
biofeedback therapy versus botox injection in treatment of dyssynergic defecation.

Conditions: Obstructed Defaecation Syndrome

Summary: assessment the improvement symptoms of obstructed defecation after biofeedback training versus botulinum toxin injection

this is a randomized controlled trial including 78 patients diagnosed with obstructed defecation syndrome confirmed by detailed history talking, full clinical examination, anorectal manometry and defecography. included patients divided into two equal groups: first group ( biofeedback therapy group) patients recieved biofeedback therapy for six sessions over one month, the second group:( botulinum toxin group) received botulinum toxin injection 100 iu in buborectalis muscle. the primary outcome is improvement of symptoms after one year

Eligibility criteria:
inclusion criteria: * patients of both genders * age of 18 years or older * fulfillment of the rome 3 constipation criteria for the past 3 months, symptom onset as a maximum six months prior to diagnosis, patients suffer from prolonged, incomplete and challenging evacuation exclusion criteria: * anismus cases with secondary reason for constipation * patients who undergone anorectal surgery patients with colonic inertia * conditions that make biofeedback training impossible * cases with primary illness causing constipation as hypothyroidism
predictive value of serum uric acid to hdl cholesterol ratio for diabetic kidney injury in type 2 diabetes

Conditions: Diabetic Kidney Injury

Summary: an prospective observetional study to asses the predictive value of serum uric acid to high density lipoprotein cholesterol ratio for diabetic kidney injury in type 2 diabetes

diabetic kidney injury (dki) is a serious microvascular complication of diabetes mellitus occuring in about 20 % to 50% of diabetic patients and is the single commonest cause of esrd.dki is asociated with arterial htn and increased cardiovascular morbidity and mortality. outcomes for both type 1 dm and type 2 dm who develop dki are significantly worse than who do not .serum uric acid was reported to be asociated with inflamatory and metabolic diseases such as metabolic syndrome , type 2 dm,thyroiditis and nafld while hdl-cholesterol decreased the odds of developing dki by 20%.it is generally accepted that hyperuricemia and low hdl-c were considered to be a risk factor of other indicators for development of dki.

Eligibility criteria:
inclusion criteria: * type 2 diabetic patients * willing and agreed to be included in the study exclusion criteria: * type 1 dm patients * patients with active urinary sediment * patients with glomerulonephritis * patients with diagnosis or clinical features that are suspicious for another systemic disease that commonly causes kidney disease * patients with evidence of alternative kidney disease * patients with history of kidney transplantation * patients with end stage renal disease * patients with family history of non diabetic forms of kidney disease * patients with active malignancy * patients with established hemolytic disease * ckd patients requiring dialysis * patients taking drugs that interfere with serum uric acid level * patients taking drugs that alter serum lipids level * pregnancy * refused to consent to this study

Keywords: dki
radiation therapy plus paclitaxel in treating patients with stage iib or stage iii breast cancer

Conditions: Breast Cancer

Summary: rationale: radiation therapy uses high-energy x-rays to damage tumor cells. drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. combining chemotherapy with radiation therapy may kill more tumor cells. purpose: phase ii trial to study the effectiveness of radiation therapy plus paclitaxel in treating patients with stage iib or stage iii breast cancer.

objectives: i. evaluate the safety and feasibility of twice a week paclitaxel and radiation therapy in patients with locally advanced breast cancer. ii. determine the pathological effects of paclitaxel and radiation in locally advanced breast cancer. outline: this is a nonrandomized, dual institution study. patients receive paclitaxel iv over 1 hour twice a week for a total of 8 weeks. this is started within 1 week of a tumor biopsy. patients receive radiotherapy 5 days/week for 5.0 weeks within 1 week of the first paclitaxel dose. operable patients who have progressive disease with the above therapy undergo a modified radical mastectomy (mrm), then receive 4 courses of doxorubicin iv and cyclophosphamide iv, administered once every 21 days. inoperable patients receive this same chemotherapy regimen, then are reevaluated for surgery. patients who have stable disease or who respond to the paclitaxel/radiation regimen undergo a mrm, then receive 4 courses of doxorubicin iv and paclitaxel iv (over 3 hours) once every 21 days. all patients with hormone receptor positive tumors receive tamoxifen for 5 years after all other therapy is completed. projected accrual: a total of 40 patients (20 patients per institution) will be accrued over 18- 24 months.

Eligibility criteria:
disease characteristics: histologically proven, untreated, locally advanced breast cancer; stage iib (t3 n0), iiia, or iiib measurable disease not inflammatory breast cancer or other stage iib (t2 n1) no distant metastases except for positive ipsilateral supraclavicular nodes patient characteristics: age: over 18 performance status: ecog 0-1 life expectancy: not specified hematopoietic: not specified hepatic: not specified renal: not specified other: not pregnant fertile patients must use effective contraception during and 6 months after treatment medically and psychologically stable prior concurrent therapy: no prior therapy of any type

Keywords: stage ii breast cancer stage iiia breast cancer stage iiib breast cancer
nitrosomonas eutropha on nitrolipids in the skin

Conditions: Inflammation

Summary: we are looking to see how the addition of nitrosomonas alters the presence of nitrolipids and inflammatory cytokines on the skin.

we are looking to see how the nitrosomonas alters nitrolipids in the skin and the inflammatory cytokines of the skin. we will be using healthy subjects over the course of 2 weeks. subjects will be using a neutral cleanser for one week prior to the study, skin microbiome,facial photography, lipid and cytokine measurements will be taken at baseline. subjects will then start using nitrosomonas spray twice daily for one week. there is a portion of the study where the subjects will have skin microbiome, facial photography, lipid measurements, blood pressure measurements and a bloow draw before and after using the nitrosomonas spray for one week.

Eligibility criteria:
inclusion criteria: * those aged 18 and over * healthy subjects with clear skin exclusion criteria: * adults unable to consent * individuals who are not yet adults (infants, children, teenagers) * pregnant women * prisoners * those with acne, eczema, seborrheic dermatitis, rosacea or polycystic ovarian syndrome * those who have started new oral medication in the last four weeks * those who have used systemic antibiotics in the last month * those who have used isotretinoin in the last 6 weeks * those who have used topical antibiotics or retinoid in the last two weeks. * those who have autoimmune or metabolic diseases * those who have changed brands of oral contraceptive within the last four weeks * those who have chronic medical disorders * those whose with active skin infections * concomitant use of nitrates * concomitant use of anti-hypertensive agents * those with syncopal episodes

Keywords: nitrolipid microbiome inflammation cytokine
feasibility of a smart device application for home-based prehabilitation

Conditions: Cancer; Prehabilitation

Summary: to investigate the feasibility of a home-based exercise training program using a smartphone application in patients planning for cancer surgery, and to determine the effectiveness of this application on functional capacity.


Eligibility criteria:
inclusion criteria: * adult patients (19-70) who are scheduled for elective cancer surgery * american society of anesthesiologists (asa) physical status classification i or ii * patients who can use a smartphone application * patients who can perform an exercise program for at least 3 weeks from the first visit to the preoperative clinic to elective surgery exclusion criteria: * patients who are unable to communicate * patients under the age of 19 and over 70 * patients who have a major medical or psychiatric disorder that is expected to affect exercise * patients with contraindications to the general rehabilitation program

Keywords: cancer patient cancer surgery prehabilitation
role of self-focused attention in depression

Conditions: Depression

Summary: using a task measuring the tracking of eye movements, the aim of this study is to demonstrate that individuals suffering from depression focus their attention more on their reflection in the screen after recalling a failure (and this all the more so as their depressive symptomatology is strong) .


Eligibility criteria:
inclusion criteria: * patients with depressive disorders according to the diagnostic and statistical manual of mental disorders (dsm-v) criteria * men or women, aged 18 to 60 * patients without mental impairment * patients without neurological impairment (epilepsy, encephalopathy, head trauma) * patients with a sufficient command of french * free patients, without guardianship or curators or subordination * patients benefiting from coverage by a social security scheme or benefiting from it through a third party in accordance with the french law on biomedical research * obtaining oral non-objection by the patient after clear and honest information about the study * patient with normal or corrected vision without rigid contact lenses exclusion criteria: * patients with an intelligence quotient \< 70 * patients aged \ 60 years * patients with mental impairment * patients with neurological impairment (epilepsy, encephalopathy, head trauma) * patients who do not speak french well enough * patients hospitalized under duress * patients without social security * patient wearing rigid contact lenses
magnetic anchoring guided endoscopic submucosal dissection for early gastric caner

Conditions: Gastric Cancer

Summary: this study uses magnetic anchored guidance system to treat early gastric cancer by endoscopic mucosal dissection to test the advantages of magnetically anchored guidance system for surgical field exposure during endoscopic mucosal dissection.

gastric cancer is the second most common malignant tumor in china, with the highest mortality rate among all types of malignant tumors. surgical resection is still the most effective treatment for gastric cancer. minimally invasive surgery breaks the traditional surgical concept that the laparotomy must be performed by laparotomy. it can complete the operation that required a large incision with minimal incision trauma, and has the advantages of less trauma, faster recovery and fewer complications. at present, the application of gastroscopy and laparoscopy for early gastric cancer has reached consensus at home and abroad. endoscopic mucosal resection of early gastric cancer is suitable for patients with intramucosal cancer and no lymph node metastasis. however, the unclear exposure of the surgical field during the operation causes difficulty in operation or conversion to open surgery is a difficult problem facing this technique. the project designed a magnetic pulling unit that can be connected through an endoscope, including external abdominal magnets, internal abdominal magnets, connecting hooks, and micro surgical tweezers. using magnetic anchoring technology, the magnetic pulling unit is anchored to the abdominal wall, and micro surgical tweezers are used. the tumor tissue is pulled indirectly, so that the mucosa is lifted up, which is beneficial to the peeling of the submucosa. this method increases the operating space of the main hand of the endoscope, and at the same time, the magnetic clamp is used to connect the clamps so that they can move in all directions, so as to achieve the desired traction of the tumor tissue site, fully expose the surgical field, and facilitate surgical anatomy.

Eligibility criteria:
inclusion criteria: * patients are diagnosed as of gastric cancer by a preliminary endoscopy or biopsy sampling exclusion criteria: * patients with a cardiac pacemaker or severe cardiac and/or pulmonary diseases * patients without informed consent * patients with other malignant tumors

Keywords: magnetic anchored guidance early gastric cancer endoscopic submucosal dissection
a study to evaluate transplantation of astrocytes derived from human embryonic stem cells, in patients with amyotrophic lateral sclerosis (als)

Conditions: ALS (Amyotrophic Lateral Sclerosis)

Summary: this is a study of transplantation of astrocytes derived from human embryonic stem cells, in patients with amyotrophic lateral sclerosis (als). there will be no change in the routine als treatment of the patients enrolled into the study. treatment will be administered in addition to the appropriate standard of care treatment. the study hypothesis is that transplantation of astrocyte(astrorx) cells can compensate for the malfunctioning of patients' own astrocytes by restoring physiological capabilities like the reuptake of excessive glutamate, reducing oxidative stress, reducing other toxic compounds, as well as by secreting different neuroprotective factors


Eligibility criteria:
main inclusion criteria: 1. el escorial criteria for probable or definite als 2. males and and non pregnant females between 18 and 70 years of age 3. patients with an als-frs-r score of at least 30 with an als diagnosis of two years or less 4. no history of active psychiatric disorder. patients receiving antidepressants as a preventive treatment, with no history of active psychiatric disorder may be included. 5. patient has a good understanding of the study and nature of the procedure 6. patient provides written informed consent prior to any study procedure 7. patients should either be on a stable dose of riluzole and/or radicava® (if applicable) for at least 30 days, or not be treated with riluzole and/or radicava® 8. patient is medically able to tolerate immunosuppression regimen 9. presence of a willing and able caregiver who understands the need to attend all follow-up visits, even if mobility declines main exclusion criteria: 1. patient has a past infection or a positive test for hbv,hcv or hiv 2. patient is in need of respiratory support 3. patient has a lower than 10/12 in als-frs-r respiratory parameters or below 70% of predicted slow vital capacity (svc) 4. patient has renal failure 5. patient has impaired hepatic function 6. patient has a body mass index (bmi) of \ 30 7. patient suffers from significant cardiac disease, diabetes, autoimmune diseases, chronic severe infection, malignant disease or any other disease or condition that may risk the patient or interfere with the ability to interpret the study results 8. patient has systemic inflammation or active infections 9. patient has been treated previously with any stem cell therapy 10. current use of immunosuppressant medication or use of such medication within 6 weeks of screening visit (visit 0) 11. patient has participated in another clinical treatment trial or received other experimental medications outside of a clinical trial within 1 month prior to start of this study 12. any known immunodeficiency syndrome 13. any concomitant disease or condition limiting patient safety to participate
rct comparing non-operative vs operative treatment of suprasyndesmotic ankle fractures.

Conditions: Ankle Fractures

Summary: weight-bearing radiographs will be used to evaluate the stability of suprasyndesmotic ankle fractures. patients with stable fractures will be randomised to operative or non-operative treatment.

suprasyndesmotic fractures (weber type c) are historically treated operatively because of the assumption that the distal tibiofibular syndesmosis is ruptured, leading to joint instability (lauge-hansen 1950, boden 1989). however, the medial deltoid ligament may function as the main stabiliser of the ankle joint by preventing external rotation of the talus and therefore maintains the dynamic congruity (michelson 2007). due to the stabilising effect of the deltoid ligament, an increasing number of transsyndesmotic fractures (weber type b) are treated non-operatively with excellent results and without the burden of complications that accompany surgery (gougoulias 2017, mittal 2017, bauer 1985). the aims of the present study are to test the stability of suprasyndesmotic ankle fractures on weight-bearing radiographs and to evaluate the effect of non-operative versus operative treatment of stable suprasyndesmotic fractures. the patients will have a weight-bearing (at least 50% of body weight) standing radiograph for the evaluation of the stability of the fracture. patients with a congruent ankle mortise (i.e., stable fracture) on weight-bearing radiographs will be randomised to either operative (orif, reference treatment) or non-operative treatment (cast). patients in both groups are allowed full weight-bearing. patients with an incongruent ankle mortise (i.e., unstable fracture) will be treated operatively according to current clinical practice and included in a parallel observational cohort study. patients who are unwilling to participate in the intervention study are also invited to participate in the observational cohort study.

Eligibility criteria:
inclusion criteria: * patients who present with a closed, isolated fibular fracture classified as suprasyndesmotic (weber c) with a medial clear space of less than 7 mm in mortise view on primary radiographs. * presentation less than 14 days after the injury. exclusion criteria: * previous fractures or ligamentous injury to the injured ankle. * pathological fracture. * diabetic neuropathy or other neuropathies. * drug abuse. * inability to consent and/or comply. * inability to understand norwegian language. * inability to walk unaided prior to the fracture. * patients with a concomitant tibial fracture requiring surgical treatment are excluded, but patients with undisplaced concomitant tibial fractures can be included. * patients from outside the catchment area of the recruiting hospitals. however, they can be included if they are willing to undergo follow-up visits at one of the recruiting hospitals.

Keywords: ankle fractures surgical treatment conservative treatment weight-bearing
extension of tablo treatment duration registry

Conditions: End Stage Renal Disease (ESRD); End Stage Renal Disease on Dialysis; Acute Kidney Injury

Summary: observational, retrospective and prospective, multicenter, post-market study of the tablo hemodialysis system in hospitalized participants with end-stage kidney disease or acute kidney injury who are prescribed renal replacement therapy \> 12 hours.


Eligibility criteria:
inclusion criteria: * participant weighs ≥ 34kg. * participant is hospitalized and has dialysis dependent end-stage kidney disease or acute kidney injury and is prescribed renal replacement therapy \> 12 hours. exclusion criteria: * any documented condition that the physician feels would prevent the participant from successful inclusion in the study.

Keywords: tablo outset medical hemodialysis aki eskd
encouraging social inclusiveness as a means to improving academic performance

Conditions: ADHD

Summary: children's peer relationships in elementary school are important to promote their academic learning and their social-emotional development. many children with or at risk for attention-deficit/hyperactivity disorder (adhd) have difficulty being accepted and getting along with their classroom peers. this study tested a classroom intervention that aimed to help improve the peer relationships of elementary school age children, with a particular focus on children with or at risk for adhd.


Eligibility criteria:
inclusion criteria: -general education teachers of grades k-5 or children in these teachers' classrooms exclusion criteria: -none

Keywords: peer relationships