Kornimate/medical-research-clean huggingface dataset:
sleep and circadian contributions to nighttime blood pressure

Conditions: Sleep; Circadian Rhythm; Blood Pressure; Hypertension

Summary: broadly, this study (scn-bp) seeks to examine sleep and circadian factors that contribute to blood pressure levels at night.

scn-bp is imbedded in a parent grant titled "improving the detection of hypertension (idh-mega)" and examines a variety of sleep (e.g., sleep duration, timing, and the presence of sleep disorder) and circadian factors in aims 1 and 2. in aim 3, the investigators will conduct a 30-hour constant routine protocol to directly examine endogenous circadian and blood pressure rhythms.

Eligibility criteria:
inclusion criteria: * participant in the parent grant (idh-mega) exclusion criteria: -

Keywords: sleep circadian rhythm circadian misalignment nocturnal hypertension non-dipping blood pressure
glycemic responses and sensory characteristics of whole yellow pea flour added to novel functional foods

Conditions: Diabetes

Summary: the objective of this study was to determine if whole yellow pea flour reduces post-prandial glycemic responses of novel food products. the second objective was to determine if whole yellow pea flour produces food products with favorable sensory characteristics including appearance, taste, smell, texture and overall acceptability, compared to corresponding food products made with whole wheat flour.

pulses, including yellow peas, are readily available and low-cost commodities that are gaining considerable momentum as functional ingredients possessing health benefits, as these food materials are high in fiber, protein, antioxidants, and low in fat. as incidence rates of type ii diabetes continue to climb, new novel ingredients that produce low-glycemic food products are in demand. consumption of whole pulses have been shown to lower post-prandial glycemic responses (jenkins and others 1983), however, their addition to foods often produces unfavorable sensory characteristics. to date, few studies have examined the feasibility of producing food products containing pulse-derived ingredients that reduce post-prandial glycemic responses, lower glycemic indexes (gi) and at the same time possess sensory qualities that appeal to consumers. since yellow peas are readily available and relatively inexpensive, they are a promising candidate for use as novel ingredients for the development of low-glycemic, consumer-friendly functional foods. the objective of the present study was to first determine the post-prandial glycemic response and gi of novel foods containing whole yellow pea flour (wypf) as a functional ingredient. the second objective was to determine the acceptability of sensory characteristics for each wypf food product.

Eligibility criteria:
inclusion criteria: * healthy men * non-lactating women * bmi's between 18 and 31 kg/m2 exclusion criteria: * heart disease * diabetes * thyroid disease * celiac disease * gluten intolerance * taking corticosteroid medications * smokers * chronic alcohol usage (\> 2 drinks/d)

Keywords: pea flour glycemic response diabetes sensory functional food diabetes control and prevention
ankle fracture vs ankle fracture-dislocation

Conditions: Ankle Fractures

Summary: the purpose of this study is to compare outcomes of patients with an ankle fracture to those with ankle fracture-dislocations. we hypothesize that long-term clinical outcomes for patients sustaining ankle fracture dislocations are poorer than those without dislocation.

orthopaedic literature has very limited data regarding outcomes following ankle fracture dislocations. increased knowledge of the long-term consequences of these injuries could usher in changes to treatment paradigms, potentially resulting in improved outcomes. thirty patients will be enrolled into two arms of this prospective study: isolated ankle fractures and ankle fracture dislocations. patients will be followed through their operative and postoperative course and clinical and radiographic assessments will be analyzed. we plan to compare the clinical, radiographic, and functional outcomes of patients with ankle fractures to those with ankle fracture-dislocations. we also plan to identify factors that contribute to or predict poor clinical, functional, and/or radiographic outcomes in patients with ankle fractures and fracture-dislocations.

Eligibility criteria:
inclusion criteria: * patients who sustain an isolated bi-malleolar or trimalleolar ankle fracture or an ankle fracture-dislocation requiring open reduction internal fixation * patients ages 18 and over * the subject is psychosocially, mentally, and physically able to understand and comply with the requirements of the study * open and closed fractures (excluding gustilo grade 3) * english must be patient's primary language exclusion criteria: * previous injury or significant osteoarthritis to the affected ankle * current ipsilateral or contralateral lower extremity injury with the exception of a contralateral ankle fracture or fracture-dislocation * retained hardware from a previous injury at or around the tibia-talar joint of the affected extremity * patients under the age of 18 * history of inflammatory arthropathy * traumatic brain injury or spinal cord injury preventing weightbearing on the lower extremities * the subject has another concurrent physical or mental condition that is likely to affect compliance with the study requirements * patients with gustilo grade 3b and 3c open fractures

Keywords: ankle fracture ankle fracture-dislocation prospective observational
humanity neurotech device clinical trial in adults with long covid cognitive dysfunction

Conditions: Post-Acute COVID-19 Syndrome; Cognitive Dysfunction

Summary: the purpose of this study is to assess the feasibility of an at-home mmt treatment in patients with cognitive dysfunction related to pasc, and to collect data on safety and efficacy to inform the design of larger clinical studies. a prospective randomized controlled study of 30 participants with pasc and moderate to severe cognitive dysfunction. total study duration will be 8 weeks, including 4 weeks of treatment and 4 weeks of untreated follow up.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * english speaking * sars cov-2 infection as documented by laboratory nucleic acid amplification test or antibody test ≥ 6 months from screening or signed attestation of positive test result * experiencing pasc symptoms ≥ 6 months * objective cognitive impairment on neuropsychological measures (as defined by a z-score ≥1 standard deviation below the normative mean) in executive functioning * individuals of childbearing age agreeing to use a highly effective form of birth control exclusion criteria: * history of cognitive dysfunction present prior to sars cov-2 infection * febrile (\> 99 f) at the time of the enrollment visit * enrollment in another interventional clinical trial in the last 90 days or during the study period * recent sars cov-2 reinfection in the last 30 days or during the study period * recent sars cov-2 vaccination in the last 30 days or plans to be vaccinated during the 8 week study period * currently taking immunomodulatory medication on an ongoing basis (nsaids, corticosteroids, cytokine antagonists, ivig) * history of bipolar disorder, psychotic disorder, substance use disorder * change in anti-depressant or other psychoactive medication or dose in the last 90 days * cranially implanted devices or metal * any serious unstable medical or neurologic condition * history of severe head injury (as defined by loss of consciousness for ≥30 minutes) or stroke in the past 12 months * pregnant or plan to become pregnant during the study as indicated by positive pregnancy test * serious immune/autoimmune diagnoses prior to sars-cov-2 infection * me/cfs diagnosis prior to first sars-cov-2 infection * existing diagnosis of post-treatment lyme disease syndrome * inability to achieve appropriate positioning of the study device on the head
development and validation for taiwan version id pain questionnaire (id pain-t) and dn4 questionnaire.

Conditions: Neuralgia; Nerve Pain; Neuropathic Pain

Summary: this prospective cohort and multi-site study aims to develop taiwan version (id pain-t) based on the original versions of id pain and also dn4, and validate both id pain-t and dn4 applied in taiwanese subjects at the clinical setting.


Eligibility criteria:
inclusion criteria: * subjects without headache pain over 30 days and at least 18 years old who will visit the clinic, inclusive of male and female. * subjects who are able to complete the id pain-t questionnaire. exclusion criteria: * subjects who are illiterate or unable to complete questionnaire. * subjects who are currently participating in another study or have participated in another pain study within one month of study entry. * subjects with low back pain are unable to participate in this study; as the sciatica caused by the piriformis (exclusive of the other types of sciatic pain), lumbago, unclear identification in nerve injury (e.g. complex regional pain syndrome type i) or mixed origin (e.g. cancer pain).
bioavailability of aliskiren and valsartan combined as a single tablet vs. the same medications given separately to healthy subjects.

Conditions: Healthy

Summary: this study will assess the bioavailability of aliskiren and valsartan as a single tablet compared to the same doses of the two drugs given as two separate tablets in healthy subjects.


Eligibility criteria:
inclusion criteria: * healthy female subjects age 18 to 45 years (inclusive) in good health as determined by past medical history, physical examination, vital signs assessments, electrocardiogram, and laboratory tests at screening and baseline.. * female subjects of child bearing potential must be using a double-barrier local contraception i.e. intra-uterine device plus condom, or spermicidal gel plus condom for at least 3 months prior to study start or postmenopausal females must have had no regular menstrual bleeding for at least 1 year prior to inclusion (menopause will be confirmed by a plasma fsh level of \>40 iu/l) or female subjects must have been surgically sterilized at least 6 months prior to screening with supportive clinical documentation. and all female subjects must have negative pregnancy results at screening and each baseline (regardless of reported reproductive status). * body mass index (bmi) must be 18 - 30 kg/m2 (inclusive) and subjects must weigh at least 50 kg. * vital signs should be within the following ranges: oral body temperature between 35.0-37.5 °c, systolic blood pressure, 90-140 mm hg, diastolic blood pressure, 50-90 mm hg, pulse rate, 40 - 90 beats per minute (bpm) exclusion criteria: * smokers (use of tobacco products within the previous 3 months). smokers will be defined who reports tobacco use or has a urine cotinine value of ≥ 300 ng/ml. * use of any prescription drugs within 4 weeks prior dosing, or over-the-counter (otc) medication (vitamins, herbal supplements, dietary supplements) within 2 weeks prior to dosing. acetominophen is acceptable, with supportive clinical documentation.. * participation in any clinical investigation within a minimum of 4 weeks prior to dosing (or longer if local regulations apply). * significant illness within the 2 weeks prior to dosing. * lactating and breast feeding females. other protocol-defined inclusion/exclusion criteria may apply

Keywords: aliskiren , valsartan, bioavailability, hypertension healthy male and female subjects
comparison of longitudinal blood pressure and arterial stiffness in preeclamptic women after delivery

Conditions: Preeclampsia and Eclampsia; Stiffness, Aortic; Blood Pressure

Summary: the investigator measured the arterial stiffness using cardio-ankle vascular index (cavi) test in patient with preeclampsia and normal pregnant women to evaluate the longitudinal change of cavi and their predictors.

this study was a case control study and included 37 women with preeclampsia (pe group) and 36 normotensive women (control group) who gave birth to child at seoul national university bundang hospital. cario-ankle vasuclar index (cavi) was measured at one day, six months and one year after delivery in both group. the investigator also checked the body weight, blood pressure, lipid profile, serum creatinine, aspartate transaminase (ast) and alanine transaminase (alt) simultaneously with cavi. the relationship between the presence of preelampsia and longitudinal changes of cavi, blood pressure and metabolic indices were evaluated using generalized estimating equation (gee) method.

Eligibility criteria:
inclusion criteria: 1. case group : women who were diagnosed preeclampsia based on the criteria of the international society for the study of hypertension in pregnancy 2. control group : normotensive women who gave birth to child at seoul national university bundang hospital. exclusion criteria: * women who were hemodynamically compromised or had bleeding complication after delivery were excluded.

Keywords: preelampsia cardio-ankle vascular index (cavi) aortic stiffness blood pressure ldl-cholesterol
a single case study of hypermetabolism

Conditions: Hypermetabolism Due to Defect in Mitochondria; Luft Disease

Summary: in the metabolic disorder clinic at the hospital for sick children, the investigators identified a male, proband with possible luft's disease. the investigators hypothesize that luft's disease is caused by excess or dysregulation of brown/beige fat tissue. to address the hypothesis, the investigators would like to assess brown fat distribution and activity in this subject.

the subject will undergo a fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18f fdg pet/ct) at the diagnostic imaging unit of the hospital for sick children.

Eligibility criteria:
inclusion criteria: * diagnosis of hypermetabolism, possible luft's disease. exclusion criteria: * none
effect of korean red ginseng (krg) on dry mouth

Conditions: Xerostomia

Summary: the purpose of this study is to determine the effect of krg (korean red ginseng) on dry mouth (xerostomia).

korean red ginseng * worldwide use * a main herb of old oriental prescriptions for dry mouth * need for correct information by rct

Eligibility criteria:
inclusion criteria: * dry mouth patients exclusion criteria: * sjögren syndrome * irradiation related xerostomia * severe psychiatric diseases * pregnancy or breast feeding women

Keywords: xerostomia panax ginseng(korean red ginseng) visual analogue scale salivary flow rates
is a knee arthroscopy of any benefit for the middleaged patient with meniscal symptoms?

Conditions: Chronic Meniscus Injury

Summary: the purpose of this study is to determine whether a knee arthroscopy is effective in the treatment of middleaged patients with meniscal symptoms also receiving a standardised exercise program.

there are no studies proving a significant positive effect of a knee arthroscopy in middleaged patients with meniscal symptoms in excess of a structured rehabilitation program. in this study consecutive patients aged 45-64 years referred to the orthopaedic department at the university hospital linköping for a suspected meniscal injury will be randomised to a rehabilitation program or a knee arthroscopy + the same rehabilitation program. functional tests will be performed by a physiotherapist. there will be patient administrated questionaries sent out after 3 and 12 month.

Eligibility criteria:
inclusion criteria: * all (consecutive) patients referred to the orthopaedic department in linköping for a suspected meniscal injury * age:45-64 years old * no gonarthrosis (ahlbäck=0) on standing radiographs exclusion criteria: * rheumatic disease * patellofemoral arthrosis * fibromyalgia * a knee or hip replacement * a neurologic disorder including stroke * a contraindication for an operation * catching or locking for more than 2 seconds more than once a week * a permanent extension deficit * patients who cannot understand instructions in swedish

Keywords: meniscal injury knee arthroscopy middleaged functional outcome
ibuprofen in migraine patients

Conditions: Migraine Without Aura

Summary: in this study, the investigators planned to compare the effectiveness of an intravenous ibuprofen against an intravenous dexketoprofen among patients (18-65 years) who were admitted to the emergency department (ed) with acute migraine-related headaches and diagnosed migraine without aura. in this study, patients who presented with migraine-related headache to emergency departments will be included in this study. two different therapy option are created; first, 400mg intravenous ibuprofen with 10mg intravenous metoclopramide hcl , second, 50 mg intravenous dexketoprofen with 10mg intravenous metoclopramide hcl. patients's headache scores will be measured with visual analog score (vas) at the pretreatment and post-treatment periods (0. minutes, 30. minutes, and 60. minutes.) 60 minutes after treatment, as a rescue therapy, 100mg tramadol will be given to patients whose headache score does not decrease by more than 50% from pretreatment-vas score.


Eligibility criteria:
inclusion criteria: * all the patients aged 18-65 years who had been admitted to the ed for headaches and diagnosed acute migraine-related headache according to the international classification of headache disorders-2018 edition * patients whose pre-treatment vas scores are more than 40 point. * patients who give written and verbal consent to include study. exclusion criteria: * patients had taken any analgesic drugs or drugs for migraine prophylaxis in the last 6 hours * patients had a history of allergy to any of the drugs used in this study * patients used any anticoagulant-agents, * patients had bleeding diathesis * patients were pregnant, * patients were breastfeeding mothers * patients who had chronic heart disease, chronic liver disease, and chronic kidney disease * patients had peptic ulcer * patients had a history of acute akathisia or acute dystonia to metoclopramide hcl

Keywords: migraine without migraine intravenous ibuprofen intravenous dexketoprofen
epidemiological features of emergent highly resistant bacteria in tunisian intensive care units

Conditions: Cross Infection; Carbapenem Resistant Bacterial Infection; Vancomycin-Resistant Enterococcal Infection; Critical Illness

Summary: investigate the epidemiology, risk factors and impact on clinical practice of healthcare-associated infections with emergent highly drug-resistant (ehdr) pathogens, particularly carbapenem resistant enterobacteriaceae and glycopeptides-resistant enterococcus.

in 2022, a previous one-day point-prevalence multicenter study (nosorea2, nct05547646) showed that most prevalent pathogens causing healthcare-associated infections were carbapenem resistant enterobacteriaceae. in 2017, (nosorea1, la tunisie medicale - 2018 ; vol 96 (10/11)), most prevalent pathogens were non-fermenting pathogens. faced with this major epidemiological change within tunisian icus, we decided to launch a 3rd survey under the aegis of the 'association tunisienne de réanimation'. we aimed to investigate the epidemiology, risk factors and impact on clinical practice of healthcare-associated infections with emergent highly drug-resistant (ehdr) pathogens, particularly carbapenem resistant enterobacteriaceae and glycopeptides-resistant enterococcus. so we conducted a multicenter prospective collection that will take place over 2 months.

Eligibility criteria:
inclusion criteria: * adult icu patients admitted during the study period exclusion criteria: * none

Keywords: critical care healthcare associated infections drug resistance
eagle - multicenter study of the european assessment group for lysis in the eye

Conditions: Retinal Artery Occlusion; Fibrinolysis; Visual Acuity; Stroke; Hemodilution

Summary: the aim of the eagle study is to compare the efficacy of conservative medical treatment and local intraarterial fibrinolysis in patients with central retinal artery occlusion and to evaluate benefit and risk for the patient of both therapies.


Eligibility criteria:
inclusion criteria: * subtotal central retinal artery occlusion or central retinal artery occlusion with choroidal hypoperfusion not lasting longer than 20h * patients aged from 18 years to 75 years (in case of pre-existing blindness of other eye also older than 75 years) * informed consent of the patient exclusion criteria: * central retinal artery occlusion lasting longer than 20h * eye diseases, namely branch retinal artery occlusion, cilioretinal arteries supplying the macula, combined arterial-venous occlusion, proliferative diabetic retinopathy and elevated intraocular pressure (over 30 mmhg) * systemic diseases, namely severe general diseases, systemic arterial hypertension (systolic pressure \> 200 mmhg), despite medical therapy, acute systemic inflammation (erythrocyte sedimentation rate \> 30 mm within the first hour/ c-reactive protein \> 1,0 mg/dl), antithrombin-iii deficiency in case of thrombocytopenia (\< 100000 per ml): pathologic clotting time, acute pancreatitis with elevated pancreas enzymes * medical history: heart attack within the last 6 weeks, intracerebral bleeding or neurosurgical operation within the last 4 weeks, therapy with marcumar/warfarin, allergic reaction to contrast agent, haemorrhagic diathesis, aneurysms, inflammatory vascular diseases (e.g., giant cell arteritis, wegener´s granulomatosis), endocarditis, gastric ulcer * patient participation in other studies during the prior 4 weeks * no willingness and ability of the patient to participate in all follow-up examinations * pregnancy * written consent not given * patient is not mobile (bedridden) * other conditions/ circumstances likely to lead to poor treatment adherence (e.g., history of poor compliance, alcohol or drug dependency, no fixed abode)