Kornimate/medical-research-clean huggingface dataset:
a register on the quality of ercp and training of endoscopists in italy

Conditions: Biliary Tract Diseases; Pancreatic Diseases

Summary: this is a prospective observational longitudinal study aim of the study is to collect information: * on the organization models of the endoscopic units performing ercp in italy * on the previous and/or ongoing training of the endoscopists performing ercp * on the clinical characteristics of patients undergoing ercp in italy as well as on the outcome

quality of ercp in italy has been object of various, mainly retrospective studies in italy, but it has never systematically and prospectively evaluated in a large prospective series. moreover, the study aim at collecting data on the organization models of the endoscopic units performing ercp in italy; on the previous and/or ongoing training of the endoscopists performing ercp; on the clinical characteristics of patients undergoing ercp in italy as well as on the outcome of the procedure the study consists of 3 phases: 1. collection of the information on the endoscopic unit and on the endoscopists who performed ercp in the center 2. collection of data regarding consecutive ercps performed in adult patients in each center including demographic, clinical and procedural information 3. definition of the the outcome of ercp assessed after 30 days from the procedure

Eligibility criteria:
inclusion criteria: * willingness to participate in the study exclusion criteria: * informed consent not subscribed

Keywords: ercp biliary diseases pancreatic diseases outcome quality training
the impact of a digital game-based learning activity on nursing students' understanding of surgical site infections

Conditions: Surgical Site Infections; Education

Summary: the aim of this randomized controlled trial was to evaluate the effect of a digital game-based learning activity on students' learning of interventions to prevent surgical site infections.this study will seek answers to the following questions: is digital game-based learning activity effective in students' learning process? is the traditional method of theoretical lecturing effective in the learning process? what is the effect of students' learning methods on their motivation? the researchers will compare the group with the theoretical lecture to see the effectiveness of the digital game-based learning activity. participants will be divided into 3 groups. in the first group, the level of learning interventions to prevent surgical site infections with digital game-based learning activity will be evaluated with pre-test and post-test in the second group, the level of learning the theoretical course and interventions to prevent surgical site infections will be evaluated with pre-test and post-test. the control group will be evaluated only with the pre-test post-test without any intervention.


Eligibility criteria:
inclusion criteria: * having a cell phone, computer or tablet device. * to have internet access on one of the cell phone, computer or tablet devices. * to have taken the surgical diseases nursing course. * to be a 4th year student of van yüzüncü yıl university faculty of health sciences, department of nursing * volunteering to participate in the research exclusion criteria: * - graduating from a health vocational high school or coming from a health-related department with vertical transfer * limited ability to read and write in turkish. * not having a software infrastructure suitable for opening digital game activities on mobile phones, computers or tablet devices
the effects of acupuncture against postoperative nausea and vomit after laparoscopic cholecystectomy

Conditions: Postoperative Nausea; Postoperative Vomiting; Laparoscopic Cholecystectomy; Acupuncture

Summary: postoperative nausea and vomiting (ponv), represents a common condition after surgery and anesthesia. acupuncture has been used for centuries for analgesia and quality of life improvement in addition to low cost. this study is a random control trial concerning the antiemetic efficacy of acupuncture associated with intravenous antiemetics in laparoscopic cholecystectomy, in comparison to patients under only antiemetic administration. one hundred patients were enrolled, regardless of their sex, age, and comorbidity and were randomly allocated in one of two groups. both anesthesia and antiemetic medication were personalized according to each patient's medical history. in the study group, after anesthesia induction and before pneumoperitoneum application, a sterile stainless steel 0,25 x 25mm acupuncture needle was inserted bilaterally at the pc6 for 20 minutes, rotated manually clockwise and then anticlockwise every 5 minutes and then removed. fisher's exact test was chosen for statistic evaluation. there were 8 ponv cases in the study group against 18 cases in the control group. fisher's exact test highlighted a p-value of p=0,03, marking the difference between the two groups as statistically significant. concluding, acupuncture presents a remarkable action against ponv after laparoscopic cholecystectomy (lpc). another remarkable trait of acupuncture is the safety that it offers during application without provoking severe adverse effects. furthermore, reduced medical costs thanks to decreased postoperative use of antiemetic medication, decreased patients' hospitalization, and reduced re-hospitalization possibility have to be noted. finally, it has to be mentioned that despite lpc is in general terms painless, the analgesic effects of acupuncture should not be disregarded


Eligibility criteria:
inclusion criteria: * adult male patients undergoing laparoscopic cholecystectomy regardless of other comorbidities. * adult female patients undergoing laparoscopic cholecystectomy regardless of other comorbidities. * to be able to communicate with personnel. exclusion criteria: * patients under 18 years old. * inflammation of acupuncture site (pc6). * inaccessible acupuncture site (eg. arm amputees, trauma). * patients unable to communicate with personnel.

Keywords: acupuncture postoperative nausea postoperative vomiting laparoscopic cholecystectomy
characterization of breast masses incidentally detected on chest ct

Conditions: Breast Cancer

Summary: although computed tomography (ct) is not routinely used to evaluate beast masses, it is common to discover incidental breast lesions on chest ct. the goal of this study is to investigate the incidence and appearance of incidentally discovered breast masses on chest ct.


Eligibility criteria:
inclusion criteria: * woman with incidentally discovered breast masses on chest ct exclusion criteria: * male gender * known breast cancer
right ventricle morphology and hemodynamics in brs

Conditions: Brugada Syndrome

Summary: the study purpose is to evaluate the morphological, functional and electrophysiological characteristics of the right ventricle before and after ajmaline in patients diagnosed with brugada syndrome as well as to correlate cmr findings and substrate size.

all consecutive patients with either spontaneous or ajmaline-induced brs-ecg pattern will be screened. a total of 30 brs patients and 30 normal age, sex and bsa matched normal controls will be selected and enrolled. patients will perform cardiac magnetic resonance imaging to evaluate and compare morphological and functional characteristics of the 2 groups before and after ajmaline. brs patients will also perform a standardized programmed ventricular stimulation protocol and electroanatomical mapping to determine the substrate size.

Eligibility criteria:
inclusion criteria: * brugada syndrome with either spontaneous or ajmaline- induced type 1 ecg pattern * indication to ajmaline testing and programmed ventricular stimulation * age \> or equal to 18 years * written informed consent exclusion criteria: * pregnancy * contraindication to cmri or to ajmaline * live espectance \< 12 months
osteopathic manipulation for female interstitial cystitis patients with sacroiliac joint dysfunction

Conditions: Interstitial Cystitis; Sacroiliac Joint Somatic Dysfunction

Summary: the proposed study will evaluate the effectiveness of osteopathic manipulation of the sacro-iliac joint (sij) and the lumbar spine in symptomatic female interstitial cystitis (ic) patients with sacro-iliac joint dysfunction. it is predicted that osteopathic manipulation for a period of 12 weeks will result in subjective indices of increased comfort and objective indices of lower o'leary-sant questionnaire, pelvic floor impact questionnaire (pifq-7), female sexual function index (fsfi) and sf-12 scores, lower visual analog scores for pain and urgency, decreased frequency on voiding diary and greater variation in resting/contraction perineometry scores.

patients will be evaluated and examined by an osteopathic physician. this examination will consist of full osteopathic structural exam, and a focused examination of the sacroiliac joint and the surrounding musculature. subjects will then be treated based on the objective findings of the examination. since the structural exam includes the whole body, other structural abnormalities will likely be identified and possible require treatment to aid in treatment of sijd. subjects will also be taught stretching routines in order to aid in treatment of the dysfunction. our control group will receive the same structural exam, and focused examination. their treatment will involve massage, in an area not associated with the musculature of the sij. this will serve to identify a possible placebo effect, associated with simply providing a healing touch without focused treatment. all of the subjects will be evaluated with standardized ic questionnaires at time of initial visit and subsequently re-evaluated with the same questionnaire in 4 week intervals. the patients will be followed for up to 6 months after treatment and evaluated at this time.

Eligibility criteria:
inclusion criteria: * female * at least 18 years of age * patients who have osteopathic dysfunction * patients with the diagnosis of ic and sacroiliac joint dysfunction * patients currently stable on or off of a treatment regimen for ic for the past one month * patients not currently undergoing physical therapy for pelvic floor dysfunction or si joint dysfunction * patients who have not used narcotics, skeletal muscle relaxants, or bladder instillations for the past month * willingness to participate in the trial by signing an informed consent exclusion criteria: * pregnancy * pelvic masses * patients with an interstim neuromodulator implant * patients requiring narcotics, bladder instillations, or skeletal muscle relaxants * history of vaginal or abdominal pelvic surgery within the last 3 months * having a bladder over-distention within the last 1 month * malignancy * known spinal arthropathies * hip replacements or other surgical stabilization * herniated disks * spinal stenosis

Keywords: osteopathic manipulation interstitial cystitis sacroiliac joint dysfunction
chronic aphasia - improved by intensive training and electrical brain stimulation

Conditions: Post-Stroke Chronic Aphasia; Anomia (Word-retrieval Impairment)

Summary: the purpose of this study is to determine if non-invasive electrical brain stimulation can enhance the out of intensive language therapy in chronic aphasia

stroke is the leading cause of death and disability worldwide. given the increasing average lifespan worldwide, the incidence and prevalence of patients with stroke will dramatically increase in the future. one of the most frequent and devastating conditions after stroke is aphasia, which affects language production and comprehension. high-frequent intensive speech-and-language therapy is currently the treatment of choice in chronic aphasia. however, despite its general effectiveness, treatment effect sizes are only low to moderate. thus, there is a pressing need to explore novel training-adjuvant therapies to enhance treatment efficacy. moreover, very little is known about the neurobiology of treatment-induced recovery in chronic aphasia. this is the prerequisite to improve existing and/or develop new treatment paradigms. thus, in the present project we aim to assess whether the outcome of intensive language training can be enhanced by adjuvant non-invasive brain stimulation. we will be using anodal transcranial direct current stimulation (atdcs) that has previously been shown to enhance (a) language and motor learning in healthy subjects and (b) motor recovery in stroke patients. specifically, in a longitudinal group comparison design, two matched groups of patients with chronic anomia will receive two weeks of intensive language training with or without atdcs. treatment effects will be assessed immediately after the two week intervention period and several months after the end of the training. we will also use functional and structural magnetic resonance imaging (mri) to elucidate language network changes in the two groups.

Eligibility criteria:
inclusion criteria: * right-handedness * single first time left-hemisphere stroke * fluent- or non-fluent chronic aphasia (more than six months post-stroke) * anomia (pr\>10 and pr\<60 aachen aphasia naming subtest) * native german speaker exclusion criteria: * more than one stroke * alcoholism, severe psychiatric conditions, other neurological conditions * other non-treated medical problems, severe microangiopathy * pregnancy

Keywords: intensive language therapy anomia magnetic resonance imaging
enhanced pain coping in cancer (epic): a study of managing treatment-related joint pain in breast cancer survivors

Conditions: Breast Cancer Survivor

Summary: the researchers are doing this study to compare two different types of group therapy and find out whether they are effective approaches for helping breast cancer survivors manage joint pain caused by aromatase inhibitors (ai). this type of joint pain is called ai-associated arthralgia, or aia, and it is common in people taking ais. aia and its associated symptoms can make some people decide to stop taking their medication. the study will look at the effects of two different types of group therapy on participants' cancer-related symptoms (such as pain, fatigue, and anxiety), their ability to continue taking ais on a regular schedule, and their quality of life. we will measure participants' quality of life by having them fill out questionnaires. both groups will have 2-hour group therapy sessions once a week, over the course of 8 weeks. during the sessions, you will be in a group of 6-10 participants, who may be a mixture of patients from both msk and university of california san diego (ucsd).


Eligibility criteria:
inclusion criteria: * age ≥18 years * english-proficient women with a history of stage i, ii, or iii breast cancer * free of oncologic disease by clinical examination and history; * receiving third-generation ai therapy (anastrozole, letrozole, or exemestane) for at least 28 days prior to consent with plan to continue for at least another 12 months; * worst joint pain rated at least 4 or greater on a 0-10 numeric rating scale in the preceding week prior to consent; * reporting at least 15 days with pain in the preceding 30 days prior to consent; * experiencing joint pain for at least one month; * pain attributed to ai therapy; * willing to adhere to all study-related procedures, including randomization to one of two treatment arms: mindfulness-oriented recovery enhancement (more) or supportive group psychotherapy (sg); * able to attend video-call sessions in a quiet/private location. exclusion criteria: * metastatic breast cancer (stage iv); * completed chemotherapy, surgery, or radiation therapy less than 4 weeks prior to enrollment; * pain attributed to inflammatory arthritis (i.e. rheumatoid arthritis, gout, pseudogout); * surgery or joint injection involving the affected joints within the last month or planned within the next six months; * active suicidality or psychosis as determined by the mini-international neuropsychiatric interview.

Keywords: enhanced pain coping in cancer mindfulness oriented recovery enhancement aromatase inhibitors arthralgia ache cancer pain cancer survivors
sleeve gastrectomy in adolescents with complicated morbid obesity and nafld

Conditions: Morbid Obesity; NAFLD

Summary: pediatric obesity has become a critical health problem worldwide, increasing the premature onset of obesity-related morbidities. this phenomenon has induce an increase in the incidence of serious health complications starting in childhood and adolescence. lifestyle interventions, including diet and regular physical activity, are the cornerstone of current medical management. unfortunately, these interventions are often ineffective in providing a meaningful and long-lasting weight loss necessary to change health outcomes. it has been demonstrated that an early intervention in obesity in children and adolescents, inducing weight loss by performing bariatric surgery in carefully selected patients, can dramatically reduce the risk of adulthood obesity and obesity-related diseases, including non-alcoholic fatty liver disease (nafld). recent evidence suggest that bariatric surgery can improve metabolic complications and liver involvement in patients affected by morbid obesity.


Eligibility criteria:
inclusion criteria: * bmi\>40 kg/m2 with severe comorbidities * type 2 diabetes mellitus * moderate-to-severe sleep apnea * pseudotumor cerebri * nash with advanced fibrosis (ishak score\>1) * bmi\>50 kg/m2 with mild comorbidities * hypertension * dyslipidemia * mild obstructive sleep apnea * chronic venous insufficiency * panniculitis * urinary incontinence * impairment in activities of daily living * nash * gastroesophageal reflux disease * severe psychological distress * arthropathies related to weight exclusion criteria: * documented substance abuse problem * medically correctable cause of obesity * disability that would impair adherence to postoperative treatment, present pregnancy, or breast-feeding the patients included in the present study were enrolled according to the recent indications for bariatric surgery in severly obese adolescents of hepatology committee of european society of pediatric gastroenterology, hepatology and nutrition (espghan) (jpgn 2015;60: 550-561)

Keywords: bariatric surgery sleeve gastrectomy
ed-treat (early detection and treatment to reduce events with agitation tool) compared to usual care

Conditions: Psychomotor Agitation; Behavioral Disorder

Summary: the purpose of this study is to conduct a a pilot trial that tests the acceptability, fidelity, and feasibility of ed-treat.

this study will be a pilot rct that compares ed-treat to usual care. the scientific premise of the proposed project is that an innovative ehr-embedded clinical decision support (cds) tool can overcome the challenges to risk assessment and suggest pre-emptive use of behavioral techniques in the emergency setting. this would help clinicians appropriately invest resources to improve the quality of care for at-risk patients regardless of ultimate medical or psychiatric diagnoses and prevent agitation from occurring. this pilot trial will (1) test the integrity of the study protocol in preparation for a future full-scale rct, (2) evaluate randomization protocols, (3) estimate rates of recruitment and retention, (4) assess acceptability and fidelity of the intervention, and (5) determine if the proposed effect size is reasonable. this registered study is actually the third aim of a larger study where the tool will be developed and assessed using observational data and input from a steering committee in aims 1 and 2 prior to pilot testing.

Eligibility criteria:
inclusion criteria: 1. adult (age≥18) patients presenting to the ynhh ed during the pilot trial period 2. deemed to have a mild-moderate or high risk of agitation as determined by ed-treat 3. do not require physical restraint orders \<30 minutes of arrival 4. with a score of "4" (quiet and awake; normal level of activity) on the behavioral activity rating scale 5. have comfort with conversational english 6. able to provide verbal consent. exclusion criteria: 1. presence of a restraint order \<30 minutes of arrival and presence of a non-violent physical restraint order where indications are not due to agitation (e.g., for protecting intubation or life-preserving equipment)
monitoring of pediatric inflammatory bowel diseases using multispectral optoacoustic tomography

Conditions: Crohn Disease; Ulcerative Colitis; Inflammatory Bowel Diseases

Summary: in this clinical trial, the intestinal wall of pediatric patients with crohns disease and ulcerative colitis will be assessed with multispectral optoacoustic tomography (msot) to characterize the optoacoustic signal of the intestinal wall and to monitor disease activity. the goal of this clinical trial is to compare the optoacoustic signal in the intestinal wall of children with inflammatory bowel diseases. the main questions it aims to answer are: * how does the optoacoustic signal in children with inflammatory bowel diseases change over time? * how does the optoacoustic signal in children with inflammatory bowel diseases change when they receive therapy? participants will be examined with multispectral optoacoustic tomography.

in this study, the disease activity of children and adolescents with inflammatory bowel disease (ibd) will be assessed non-invasively by multispectral optoacoustic tomography (msot). ibds play an important role in pediatric and adolescent medicine. the most common entities in the ibs group are crohn's disease (cd) and ulcerative colitis (uc). patients with cd develop chronic intermittent transmural inflammation of the gastrointestinal (gi) tract. symptoms include diarrhea, hematochezia, abdominal pain, and malnutrition. complications of the disease include fistula formation, perforations, and bleeding.the basis for many clinical decisions is the detection of disease activity.there are limitations to previous imaging methods for routine monitoring that are particularly relevant in pediatric and adolescent medicine.the use of contrast media, sedation, and invasive procedures are a burden for pediatric patients\*.multispectral optoacoustic tomography (msot) offers a radiation-free and noninvasive alternative for detecting disease activity. quantitative assessment of hemoglobin signal in the bowel wall of patients with cd could previously be correlated with endoscopically detected disease activity. the aim of this study is to evaluate whether msot also allows monitoring of chronic inflammatory diseases in children. for this purpose, children in different stages of disease who regularly receive intravenous therapeutic administrations of biologics (e.g. infliximab) in our hospital will be examined. the investigators think that by means of msot different stages and courses of the diseases could be measured non-invasively and thus invasive measures in children could be reduced.

Eligibility criteria:
inclusion criteria: * existing diagnosis of cd or uc, or suspected cd or uc at initial diagnosis. * age 2 - 18 years * written declaration of consent from parents / legal guardians exclusion criteria: * pregnancy * nursing mothers * cardiopulmonary unstable patients\*: need for continuous cardiopulmonary monitoring * tattoo in the area of the examination field * subcutaneous fat \> 3 cm

Keywords: msot optoacoustics photoacoustics