Kornimate/medical-research-clean huggingface dataset:
breathing exercise for chronic pain management in breast cancer survivors

Conditions: Chronic Pain; Breast Neoplasms; Cancer Survivors

Summary: the study will follow the mrc framework to develop an evidence-based be intervention protocol to help breast cancer survivors with better management of cancer-related chronic pain.

cancer-related chronic pain remains as a big challenge for cancer survivors, which significantly affects the quality of life of cancer survivors. evidence suggests that pain is well managed through combination of pharmacological and non-pharmacological interventions. among all non-pharmacological interventions, breathing exercise (be) might have potential effect for chronic pain management in cancer survivors, but the evidence is sparse in current literature. therefore, this study will follow the medical research council framework for developing and evaluating complex intervention (the mrc framework) to develop an evidence-based be protocol to help with cancer-related chronic pain management in breast cancer survivors. the first two phases of the mrc framework will be included in this study. in the first phase, an evidence-based method will be utilized to develop the be intervention protocol. in the second phase, a pilot randomised controlled trial (rct) will be conducted to examine the feasibility of study and the acceptability of the be intervention by the participants as well as to preliminarily assess the effect of the be on chronic pain management in breast cancer survivors. semi-structured interviews will be conducted after the rct to explore participants' experiences of participating in the study and practicing the be.

Eligibility criteria:
inclusion criteria: 1. female breast cancer survivors ≥18 years age; 2. has a confirmed diagnosis of breast cancer at stage i, ii or iiia; 3. has been experiencing pain since cancer diagnosis constantly or intermittently for ≥3 months, with the average pain intensity in the last seven days on a numerical scale ≥4/10 ("0" indicates no pain and "10" indicates the worst pain); 4. has completed active anticancer treatment (such as chemotherapy, radiotherapy, surgery) for at least three months; 5. agrees to participate in the research and is willing to give informed consent; 6. can read and understand mandarin chinese. exclusion criteria: 1. extremely weak and unable to perform the breathing exercises; 2. mentally incapable (i.e., unable to follow the study instructions); 3. has scheduled pain management interventions, such as having a procedure or operation; 4. receiving other pain relief treatments, such as acupuncture, yoga, qigong, exercise program, etc.; 5. has any pre-existing chronic pain conditions before cancer diagnosis, such as arthritis, rheumatoid arthritis, chronic low back pain, migraines, trigeminal neuralgia, fibromyalgia, joint dysfunction, complex regional pain syndrome, endometriosis, etc.

Keywords: pain management chronic pain breast neoplasms cancer survivors breathing exercises
walnut shell glasses moxibustion for dry eye syndrome

Conditions: Dry Eye

Summary: this trial is designed to evaluate the efficacy of walnut shell glasses moxibustion for dry eye syndrome compared with sodium hyaluronate eye drops.


Eligibility criteria:
inclusion criteria: 1. eyes are in line with dry eye diagnostic criteria. 2. age 18 to 75 years, 3. signed informed consent, voluntary adherence to treatment for more than 1 month. exclusion criteria: 1. combined with other eye disease (such as conjunctiva, cornea and iris have significant lesions). 2. eye surgery within 3 months. 3. pregnant or lactating women. 4. oral the drugs which could inhibit lacrimal gland secretion. 5. severe meibomian gland dysfunction. 6. severe eye burns, chemical injury patients. 7. combined with cardiovascular and cerebrovascular, liver, kidney and hematopoietic system and other serious primary disease, mental patients. 8. patients with sjogren's syndrome. 9. patients who are participating in other drug clinical trials. 10. patients who are using other drugs or therapies for the treatment of dry eyes.

Keywords: walnut shell glasses moxibustion dry eye randomized controlled trial
copd exacerbation and pulmonary hypertension trial

Conditions: Acute Exacerbation of COPD

Summary: this trial will investigate whether patiens admitted with an acute exacerbation of chronic obstructive lung disease and pulmonary hypertension will benefit from a targeted pharmacological treatment.

during admittance due to acute exacerbation of chronic obstructive lung disease will patience have an echocardiography to examine their pulmonary pressure. if patient have a tricuspidal return gradient above 40 mmhg, they will receive treatment with a phosphordiesterase-5-inhibitor, sildenafil.

Eligibility criteria:
inclusion criteria: * copd verified by specialist and spirometry * admitted with the diagnosis "acute exacerbation of copd" * tr-gradient ≥40 mmhg verified by specialist and echocardiography * informed consent exclusion criteria: * known pulmonal hypertension * known heart disease which affects the pump function of the heart * men \<40 years * women \<55 years * not-menopauseal women \<55 years (menopause is defined as no menstruation within 12 months.) * severe mental illness which significantly complicates cooperation * severe language difficulties which significantly complicates cooperation * known allergy to sildenafil * sildenafil consumption ≥50 mg / week due to other indications

Keywords: copd chronic obstructive lung disease increased pulmonary pressure acute exacerbation aecopd
randomized and controlled clinical trial to evaluate bacterial adhesion on multi-im® transepithelial components

Conditions: Biofilm Formation

Summary: this study evaluates the efficacy of mutli-im® transepithelial components in the inhibition of bacterial adhesion. the control group will be the multi-im® transepithelial component with the conventional surface (multi-im® machined) and the experimental group will be the multi-im transepithelial components with the ti-golden® surface (multi-im golden) or with the nanogolden surface (multi-im® nanogolden). periodontal indices and biofilformation will be assessed during 2 months after implant loading. metagenomic analysis and pcr technique will be implemented to assess the biofilm formation.


Eligibility criteria:
inclusion criteria: * indication of having to place at least three dental implants. * plate index ≤ 20% and absence of evidence of active periodontal disease. * bleeding index of adjacent teeth ≤ 30%. * probing depth in adjacent teeth \<4 mm. * not having used systemic antibiotics during the last 6 months. * non smoker. * possibility for observation during the treatment period. * having signed the informed consent. exclusion criteria: * suffering any alteration or serious hematologic disease. * being undergoing or having received in the 30 days prior to inclusion: radiotherapy, chemotherapy or immunosuppressive treatments, systemic corticosteroids and/or anticoagulants. * presence of malignant tumors, hemangiomas or angiomas in the area of implant placement. * patients undergoing treatment with bisphosphonate drugs, both orally and intravenously. * metabolic bone disease. * diseases that affect the oral mucosa. * diabetic patients. * severe parafunctional habits and/or temporomandibular joint disorders. * pregnant or lactating women. * physical or mental inability to maintain a good oral hygiene. * being participating in another study. * in general, any inability to participate in the study.

Keywords: biofilm peri-implantitis metagenomic analysis abutment
ramipril, endothelial function and endothelial progenitor cells in patients with systemic lupus erythematosus

Conditions: Systemic Lupus Erythematosus

Summary: the aim of this study was to evaluate the effect of ramipril on the endothelial function and on the number of endothelial progenitor cells (epcs) in systemic lupus erythematosus (sle) patients.

the early detection of additional risk factor for cardiovascular diseases (cvd) such as endothelial dysfunction and low number of epc in sle patients, and an intervention proven effective could reduce the cardiovascular morbidity and mortality. no study assessed the effect of ramipril on endothelial function and epcs in sle patients.

Eligibility criteria:
inclusion criteria: * sle according 1997 modified american college rheumatology criteria * age older than 18 years * stable treatment for lupus for at least 3 months exclusion criteria: * previous coronary artery disease * hypertension * dyslipidemia (ldl\>149 mg/dl) * renal insufficiency (creatinine ≥1.4 mg/dl) * diabetes * smoking * obesity (bmi≥30) * pregnancy * menopause * patients taking statins or angiotensin convertor enzyme inhibitor within the last 6 months

Keywords: systemic lupus erythematosus endothelium ramipril
home air quality impact for adults with asthma

Conditions: Asthma; Environmental Exposure; Home Environment Related Disease

Summary: the purposes of this study are to determine the practicality of using home indoor air quality monitoring and a smartphone app to identify home air quality changes and how these changes affect adults with asthma.

the aims of this feasibility study are: 1) determine the feasibility and usability of: (a) ecological momentary assessment (ema) to assess self-report residential environmental exposures and asthma symptoms, (b) home monitoring of objective environmental exposures (total volatile organic compounds \[vocs\], particulates \[pm2.5\]), and lung function (home spirometry); 2a) assess the frequency and degree of residential environmental exposures (e.g., disinfectants/cleaners, second-hand smoke) via (a) self-reported data, and (b) home monitoring objective measures, 2b) assess the level of asthma control as indicated by self-reported asthma symptoms and lung function; and 3) explore associations of self-reported and objective measures of residential environmental exposures with self-reported and objective measures of asthma control. participants will receive an indoor air quality monitor and a home spirometer to measure vocs, pm2.5, and forced expiratory volume percent predicted, respectively. ema will be collected using a personal smartphone and ema software platform. participants' will be sent scheduled and random ema notifications to assess asthma symptoms, environmental exposures, lung function, and mitigation strategies. after the 14-day data collection period, participants will respond to survey items related acceptability, appropriateness, and feasibility.

Eligibility criteria:
inclusion criteria: * adults who previously participated in the online global covid-19 and asthma study, indicated willingness to be contacted for future research, and reported high use of disinfectant/cleaning products since covid-19 (≥5 per week). * current asthma control test (act) ≤19 * own a smartphone * have a wi-fi/wireless internet connection in their home. exclusion criteria: * non-us residents * non-english speaking

Keywords: volatile organic compounds particulate matter home air quality asthma control ecological momentary assessment home air quality monitoring smartphone technology home spirometry
vitamin a absorption from cassava in women

Conditions: Vitamin A Deficiency

Summary: the purpose of this study is to determine the vitamin a equivalents in high-carotenoid varieties of cassava.

we plan to conduct a single site intervention phase ii intervention study in healthy adult women. women will serve as their own controls, and will be fed three treatments in random order: a single meal of low-carotenoid cassava porridge with fat, a similar meal of bio-fortified cassava (that is high in vitamin a-forming carotenoids) with fat, and a similar meal of bio-fortified cassava without fat. carotenoids and vitamin a will be measured in the triacylglycerol-rich lipoprotein (trl) fraction of plasma by standard methods involving ultracentrifugation (to concentrate the trl fraction) followed by reversed-phase hplc using electrochemical detection. we plan to collect sufficient data to identify the times of the first appearance and peak concentrations in retinol, retinyl esters, alpha-carotene (ac), beta-carotene (bc), beta-carotene isomers (bci), and cryptoxanthin (cx) in trl: when a single meal containing moderately high amounts of carotenoids from bio-fortified cassava is fed to healthy adult women. we will use this data to determine the vitamin a equivalency of bio-fortified cassava in adult women, and the effect of fat on vitamin a equivalency of bio-fortified cassava.

Eligibility criteria:
inclusion criteria: * non-smoking * bmi between 18-30 * total cholesterol concentrations between 90 and 225 mg/dl * blood pressure under 140/90 mm hg * hemoglobin above 11.5 g/dl * blood chemistries within the normal range exclusion criteria: * must not be pregnant or trying to get pregnant * must not be taking fat, triacylglycerol, or cholesterol lowering medications) such as orlistat, gemfibrozil, niacin, lovastatin, simvastatin, colestipol, and ezetimibe) * must not taking medicines containing high doses of retinoids such as accutane or high vitamin a or carotenoid supplements * must not have blood chemistry or health history results consistent with acute cancer or heart disease * no obvious psychological or sociological problems such as alcoholism, drug abuse, or severe and acute mental illness that would influence their ability to sign an informed consent agreement or to participate in study duties and activities * must not be allergic to cassava, peanuts, or peanut oil

Keywords: vitamin a
alzheimer's and blood glucose levels

Conditions: Mild Cognitive Impairment; Alzheimer Disease

Summary: the alzheimer's and blood glucose levels study is researching the differences in blood glucose levels between people with and without mild cognitive impairment or alzheimer's disease with the aim of early detection of alzheimer's disease.

this study will collect continuous glucose monitor (cgm) data from participants already using cgms to better understand the relationship between alzheimer's disease and blood glucose levels. this study will use the " endobits companion " app for data collection. the endobits companion app is freely available for android and ios mobile devices, and was designed to keep track of patients diabetes management through a journal and relay this information with their cgm readings to their caring physician.

Eligibility criteria:
inclusion criteria: * for the case group: have been diagnosed with mci or ad within the past 5 years. * for the control group: have not been diagnosed with mci or ad or another major dementia disease * currently using a continuous glucose monitor (cgm). * willing and able to provide informed consent, and to have their data collected through the endobits companion app. if the participant themself is unable to provide informed consent, it will be sought from their primary caregiver. exclusion criteria: * patients younger than 50 years of age. * patients with a bmi lower than 18 or higher than 35. * patients with a major psychiatric illness (e.g., major depressive disorder, schizophrenia, bipolar disorder) * patients diagnosed with another major dementia disease, including vascular dementia, lewy body disease, huntington's disease, creutzfeldt-jakob disease, and parkinson's disease.
intermittent negative pressure to improve blood flow in patients with peripheral artery disease: effects after long-term treatment

Conditions: Peripheral Arterial Disease; Intermittent Claudication

Summary: studies have shown that intermittent negative pressure (inp) can induce short-term increase in blood flow in the extremity in patients with peripheral artery disease (pad). case reports also have indicated that inp treatment has beneficial hemodynamic and clinical effects in patients with lower limb ischemia and hard to heal leg ulcers. however, the clinical and physiological effects of long-term inp treatment are not well documented and needs further investigation.

a double-blinded randomized sham-controlled trial. otivio as is the developer of flowox, a noninvasive ce marked device to increase blood flow to the lower extremity. the device acts as a pressure chamber sealed around the patient's lower leg, applying pulses of intermittent negative pressure and atmospheric pressure. the pressure pulses are generated by a control unit, alternating between removing air from- and venting the pressure chamber. preliminary tests indicate a significant increase in blood flow to the extremity during inp treatment at -40 mmhg, but a similar increase in blood flow was not detected during treatment inp treatment at -10 mmhg. hence, treatment with -10 mmhg, may serve as a sham intervention, when evaluating the clinical and physiological effects of long-term inp treatment. all patients will receive best medical treatment including advice for smoking cessation, dietary advice, and advice for physical exercise, and pharmacological treatment with statins and platelet inhibitors. patients will be randomized into two groups, one group receiving inp treatment with a pressure of -10 mmhg, the other group receiving inp treatment with a pressure of -40 mmhg. treatment will be conducted by the patient him/herself at home, one hour in the morning and one hour in the evening for 12 weeks. pain-free- and maximal walking distance, ankle-brachial index, arterial blood flow during application of inp, maximal blood flow, and biomarkers of inflammation and endothelial dysfunction will be registered at baseline and after 12 weeks to evaluate the effects of long-term inp treatment.

Eligibility criteria:
inclusion criteria: * ankle-brachial index \< 0,9, and intermittent claudication exclusion criteria: * incapable to make an informed consent * inability to perform a treadmill test * inability to independently operate flowox * severe heart disease such as unstable angina pectoris, severe heart failure (nyha iv), severe valve failure * severe copd
diagnosing and treating low blood sugar levels

Conditions: Hypoglycemia; Insulinoma

Summary: hypoglycemia is the term used to refer to lower than normal levels of blood sugar. this study will continue to research the causes of hypoglycemia. patients involved in the study will be admitted to the clinical center of the national institutes of health and undergo tests for evaluating blood sugar. patients will be required to refrain from eating for a set period of time and will undergo blood tests for insulin levels and several other specific diagnostic tests related to insulin secretion. the patients will be under supervision and will be provided with appropriate medical and surgical attention as needed.

study description: the purpose of this study is to gain knowledge and experience in the diagnosis and therapy of patients with fasting hypoglycemia due to diverse etiologies, such as insulinomas. study subjects will be evaluated and treated for their particular condition according to standard care. objectives: 1. to understand the pathophysiology and various causes of hypoglycemia (e.g., insulinomas, men1, men2). 2. to identify new circulating biomarkers of insulinomas. 3. to create a repository of clinical data and samples for future research of insulinomas. endpoints: none

Eligibility criteria:
* inclusion criteria: in order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. male, females ages \>= 18. 2. patients with documented fasting blood glucose below 55 mg/dl. 4. patients with biochemical evidence for insulinoma or other pancreatic neuroendocrine tumors. exclusion criteria: an individual who meets any of the following criteria will be excluded from participation in this study: 1. patients with significant cardiac disease will be excluded. 2. subjects who are pregnant per self-report. 3. medically unstable per the assessment of the pi.

Keywords: hypoglycemia insulinoma natural history
detection of left atrial appendage (laa) thrombus: comparison of cardiac magnetic resonance imaging and transesophageal echocardiogram

Conditions: Left Atrial Appendage Thrombi

Summary: the purpose of this study is to compare cardiac magnetic resonance (cmr) imaging with transesophageal echocardiography (tee) in detecting the presence of laa thrombi in men and women with atrial fibrillation presenting for cardioversion.

the identification of left atrial appendage (laa) thrombus prior to cardioversion for patients with atrial fibrillation is crucial. laa thrombus can be a frequent cause of cerebral stroke or peripheral embolism post cardioversion, and anticoagulation therapy is required in these instances to prevent cerebral events and avoid embolization. to date, tee has been considered the clinical reference in detection of laa thrombi with high diagnostic accuracy. however, diagnosis and size estimation of laa thrombi remains challenging due to the complex anatomy of the laa, and transesophageal echocardiography (tee) is considered a semi-invasive procedure. to date, there have been few comparative studies involving tee and cardiac magnetic resonance (cmr) imaging, and the results have been conflicting. with newer cmr imaging techniques now available, we hypothesize that comparable results will be achieved in detecting laa thrombus in subjects using a less invasive procedure.

Eligibility criteria:
inclusion criteria: * atrial fibrillation exclusion criteria: * icds * pacemakers * intracranial clips * intracranial stimulator devices * insulin pumps * intra ocular metal foreign bodies * cochlear implants * laa amputation as part of cabg and/or valve surgery * gfr \< 60 ml/min

Keywords: left atrial appendage thrombi transesophageal echocardiogram cardiac magnetic resonance imaging atrial fibrillation cardioversion
hypotension prediction index: correlations between invasive and non-invasive pressure points.

Conditions: Hypotension

Summary: to evaluate the clinical performance of the hypotension prediction index obtained from the continuous, non-invasive clear sight monitor.

to evaluate the clinical performance of the hypotension prediction index obtained from the continuous, non-invasive clearsight monitor.

Eligibility criteria:
inclusion criteria: * all patients 18 years or older undergoing surgery with the use of general anesthesia and with planned arterial catheter placement and use of the hpi monitor. exclusion criteria: * adults unable to consent * individuals who are not yet adults ( infants, children teenagers) * pregnant women * prisoners
a controlled pregabalin trial in fibromyalgia

Conditions: Fibromyalgia

Summary: to evaluate the efficacy and safety of pregabalin compared with placebo for the relief of pain associated with fibromyalgia and improvement of function of patients with fibromyalgia


Eligibility criteria:
inclusion criteria: * patients must meet the acr criteria for fibromyalgia (ie, widespread pain present for at least 3 months, and pain in at least 11 of 18 specific tender point sites. * patients must have a score of \>40 mm on the visual analog scale exclusion criteria: * patients with any widespread inflammatory musculoskeletal disorders, widespread rheumatic diseases other than fibromyalgia, active infections, or untreated endocrine disorders.
australian barrett's cohort with dysplasia and early cancer study

Conditions: Barrett's Esophagus

Summary: the purpose of this study is to collect prospective observational data regarding endoscopic management and outcomes of patients with barrett's oesophagus (bo) with high grade dysplasia and/or intramucosal carcinoma. to observe the natural history of patients with low grade dysplastic and non dysplastic barrett's oesophagus


Eligibility criteria:
inclusion criteria: * can give informed consent to trial participation * age greater than 18 * barrett's oesophagus exclusion criteria: * age less than 18 * pregnant patients