Kornimate/medical-research-clean huggingface dataset:
efficacy of manual therapy and sacroiliac joint injection in sacroiliac joint dysfunction

Conditions: Sacroiliac Joint Somatic Dysfunction

Summary: the purpose of this study is to compare the efficacy of manual therapy and sacroiliac joint injections in patients with sacroiliac joint dysfunction


Eligibility criteria:
inclusion criteria: * low back and/or gluteal pain and/or groin pain without radicular extension below the l4 level for more than 3 months * pain score greater than 3 according to nrs * unresponsiveness to conservative treatment (such as exercise, nsaid) * at least 3 of the five sacroiliac provocation tests (faber (patrick), thigh thrust, gaenslen, sacroiliac compression, and sacroiliac distraction tests) are positive exclusion criteria: * refusing to participate in the study * pregnancy * history of inflammatory disease (ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, etc.) * infective sacroiliitis * malignancy * osteoporosis * mechanical lumbosacral pathologies (spondylolisthesis, scoliosis, stenosis, etc.) * neurological finding in the lower extremity * pain spreading below the knee * history of spinal surgery * history of allergy to drugs to be injected (local anesthetic, contrast material, steroid allergy)

Keywords: sacroiliac joint dysfunction manuel therapy sacroiliac joint injection
maternal immunization: giving immunity for tomorrow

Conditions: Pregnancy; Influenza

Summary: study objectives are to compare * influenza antibody levels in infant sera and maternal colostrum or breast milk at delivery, 2, and 6 months women who receive influenza immunization in early pregnancy, late pregnancy, or no influenza immunization during pregnancy and their infants study hypotheses are that infants born to pregnant women who receive influenza immunization in late pregnancy will have * higher levels and a longer serum influenza antibody duration in sera (hemagglutination inhibition (hai) titers) and colostrum/breast milk (influenza-specific iga and igg by enzyme-linked immunosorbent assay (elisa) than infants of women immunized in early pregnancy or not immunized


Eligibility criteria:
inclusion criteria: pregnant women 18-45 years of age from 8-36 weeks gestation in good health as determined by medical history and recent physical exam who * receive prenatal care at the uuhs obstetrics and gynecology clinics and their infants * plan to seek care for their infant at the uuhs affiliated pediatric clinics (uuhs or smc pediatric clinics) * plan for their infant to receive influenza immunization at 6 and 7 months of age exclusion criteria: * maternal history of either a congenital or acquired immunodeficiency including infection (e.g. hiv), chronic steroid use, or malignancy * serious underlying neurological, cardiac, renal, or pulmonary disease in either the mother or infant * multiple gestation * antenatal or postnatal detection at delivery of any major birth defect in the infant * delivery of the infant before 37 weeks

Keywords: maternal immunization infant immunization influenza vaccine passive transfer of immunity
6-year follow-up of dysphagia in patients with parkinson's disease

Conditions: Parkinson Disease; Dysphagia

Summary: we recruited 116 patients with idiopathic pd who were from the neurology clinic of the second affiliated hospital of zhejiang university, school of medicine from january 2014 to november 2014. perform videofluroscopic swallowing study and psychiatric and neurological evaluations and followed up after 6 years.

in baseline, 116 patients with idiopathic pd were recruited from the neurology clinic of the second affiliated hospital of zhejiang university school of medicine according to the united kingdom pd society brain bank clinical diagnostic criteria. they were admitted from january 2014 to november 2014, and were followed up after 6 years. perform psychiatric and neurological evaluations. and use videofluoroscopic swallowing study (vfss) to assess the swallowing function of pd patients. added 200mg of barium sulfate to 286ml water to achieve a concentration of 60%. add a thickener (ourdiet swallow, ourdiet biotech co. ltd, guangzhou, china) to prepare juice and pudding viscosities, no thickener was added to the liquid viscosity. the patients were advised to have boluses of 3, 5 and 10 ml of the liquid, juice, pudding viscosities in sequence according to the clinician's instructions under x-ray fluoroscopy. the patients ware sitting or standing, the lateral view of the patients' swallow was recorded by a camera (30 frames per second). the radiologist, the clinician, and the rehabilitation therapist completed this examination. two person analyzed the video in slow motion and frame - by - frame, and record abnormal results. the vfss inspection parameters are penetration/aspiration score and residue score. in order to reduce the influence of drugs on dysphagia, all patients were in the off - period. the patients stopped taking anti-parkinson's disease drugs from 9 o'clock the night before the examination, and were tested in the morning (free of medicine for more than 12 hours). the patients had completed the above tests in 2014 and were asked to perform the above assessments again.

Eligibility criteria:
inclusion criteria: * idiopathic pd according to the united kingdom pd society brain bank clinical diagnostic criteria. exclusion criteria: * (1) parkinsonian syndromes;(2) with severe lung disease, severe liver insufficiency and cardiac insufficiency; (3) kubota water drinking test grade ≥3; (4) have had or combined other diseases that affect swallowing function; (5) nasal feeding, gastric reflux or gastrostomy; (6) mental disorders or patients with low intelligence and cognitive function, unable to understand and cooperate with the examination.

Keywords: parkinson's disease dysphagia
predicting the quality of response to specific treatments in patients with cgvhd, pqrst study

Conditions: Chronic Graft Versus Host Disease

Summary: this trial collects clinical data and blood samples to predict the quality of response to specific treatments in patients with chronic graft-versus-host disease (cgvhd) who are about to start a new therapy. collecting and analyzing clinical data and blood samples from patients with cgvhd before and after treatment initiation may help doctors identify changes that may predict treatment response.

outline: this is an observational study. patients complete questionnaires over 10 minutes about physical symptoms, activity level, and emotional well-being and have their medical records reviewed at baseline, 1, 3, and 6 months after starting index treatment, and at start of a new systemic treatment. patients also undergo collection of blood samples over 1-2 minutes at baseline and at 1 month after starting index treatment, or at a treatment change visit if new therapy has not started.

Eligibility criteria:
inclusion criteria: * adults age 18 or older * prior allogeneic stem cell transplant, with any graft source, donor type, and gvhd prophylaxis * no evidence of persistent or progressive malignancy at the time of enrollment * agrees to be evaluated at the transplant center before a new line of treatment is started (may be concurrent with the enrollment visit), and later between 2-6 weeks, 3 months and 6 months after index treatment is started or if an additional new therapy is started before 6 months * signed, informed consent exclusion criteria: * inability to comply with study procedures * uncontrolled psychiatric disorder * anticipated survival \< 6 months
observational study to evaluate the therapeutic effectiveness and safety of olomax tab

Conditions: Hypertension; Dyslipidemia

Summary: throughout this study, the efficacy and safety information of olomax tablets will be collected from 24 weeks to 48 weeks(+8 weeks) the data collection point is baseline, at more than 24 weeks, at more than 48 weeks(+8 weeks).

the study will start after investigator determines the administration of olomax tablets based on the investigator's judgement and obtaining informed consent from the subject during subject's daily visit. the dose of the olomax tablet for each subject will be determined based on efficacy and drug resistance according to the subject's previous drug administration. throughout this study, the efficacy and safety information of olomax tablets will be collected from 24 weeks to 48 weeks(+8 weeks) the data collection point is baseline, at more than 24 weeks, at more than 48 weeks(+8 weeks). efficacy of olomax tablets will be evaluated based on the data collected from more than 24 weeks to 48 weeks(+8 weeks) from the baseline visit. safety of olomax tablets will be evaluated based on the adverse events collected during the study peroid.

Eligibility criteria:
inclusion criteria: 1. adults over the age of 19 2. patients eligible for olomax tab. prescription in accordance with the approved product manual in korea 3. patients who are determined to prescribe olomax tab. at the discretion of the investigators. * antihypertensive agent: do not include more than 3 agents. * anti-abnormal lipidemia: do not include more than 2 agents. * subjects who are already administered beta blocker (bb) or diuretics due to other diseases such as angina, not for the purpose of treating hypertension may be included. 4. consent on the use of information by the patient exclusion criteria: 1. patients who have already administered olomax tablets. 2. subject who fall under ' do not administer to the following patients' in the precautions for use 3. a patient who does not meet the inclusion/exclusion criteria participates 4. the patient withdraws consent for the study 5. the administration of the study drug is discontinued 6. it is impossible to follow up during the observation period 7. the investigator determines that it is no longer feasible to continue the study
effects of different exercise programs for people with chronic whiplash associated disorders

Conditions: Whiplash

Summary: background: costs of health care consumption and sick leave 2006 in sweden for whiplash associated disorders (wad) was estimated to be 4 billion swedish crowns. despite tremendous costs and personal sufferings there are only a few prospective randomized studies (rct) in patients with chronic wad, and none of them evaluating return to work, or the role of neck specific exercises with or without a combination of a behavioral approach compared with prescribed physical activity. aim: the general aim of this rct is to examine what neck-specific training with or without a combination with behavioral approach adds to prescribed physical activity of persons with chronic wad with regard to pain intensity, physical and psychological function, health care consumption and return to work. another aim is to study predictive factors of importance for a good outcome of rehabilitation. method: after informed consent patients in age 18-63 years of age with wad ii-iii with more than 6 months duration will be randomized to one out of the three alternatives of physiotherapy, treatment with medical exercise therapy with neck specific exercises (a),treatment with a behavioral approach combined with neck specific exercises (b), prescribed physical activity (c). randomisation will be done by the central project leader. 200 patients will be included in the study. all physiotherapists engaged in the structured and well described treatment will be introduced in the program by the project leader. the measurements with good clinometric properties will be performed before treatment, after 12 weeks, 6, 12 and 24 months after inclusion into the study. clinical measurements will be performed by a blinded investigator. background data, disease-specific and generic data will be measured by self-evaluated answered questionnaires by the patients. days of sick-leave will be collected from the social insurance agency. main outcomes of the measurements are pain intensity, neck specific disability and return to work. cost-effectiveness will be calculated.


Eligibility criteria:
inclusion criteria: * age 18-63 years * wad ii-iii * remaining problems (\>10mm on 100mm visual analogue scale (vas) or \>20% on neck disability index (ndi) or at least moderate pin on ndi) at least 6 months but no more than 3 years after whiplash trauma exclusion criteria: * myelopathy * earlier fracture or luxation of the cervical column, earlier neck injury * spinal tumour * spinal infection * surgery in the cervical column * malignity * systematic disease or another injury contraindicated to perform the treatment program or the measurements. * diagnosed severe psychiatric disorder * unconscious in connection to the trauma * known drug abuse * lack of familiarity with the swedish language

Keywords: whiplash rehabilitation physiotherapy exercises
ultrasound acute chest syndrome sickle cell disease

Conditions: Acute Chest Syndrome; Sickle Cell Disease

Summary: feasibility and reliability of ultrasound in the inpatient hematology setting.

acute chest syndrome (acs) is a complication of sickle cell disease where individuals have symptoms of fever, low oxygen levels or difficulty breathing in the setting of a new lung finding on chest x-ray. chest x-ray is a useful tool to identify it but has some side effects. the investigators think ultrasound will be an equally feasible, reliable tool and minimize some of the side effects associated with chest x-ray. ultrasound is a non-invasive was to obtain an image that does not require radiation.

Eligibility criteria:
inclusion criteria: 1. age: 0-25 years old 2. diagnosis: patients with a documented diagnosis of sickle cell disease (any genotype) 3. disposition: hospitalized for a scd-related complication (e.g. voc) exclusion criteria: 1. patient is considered hemodynamically unstable to undergo consent and study procedures 2. already has diagnosis of acs prior to admission to inpatient unit 3. pocus operator not available

Keywords: sickle cell disease sickle cell anemia acute chest syndrome pocus ultrasound
effects of home-based high-intensity inspiratory muscle training for stress urinary incontinence

Conditions: Stress Urinary Incontinence (SUI)

Summary: strengthening the diaphragm muscle, the roof of the pelvic floor muscles (pfm), may be an alternative intervention in patients suffering from stress urinary incontinence (sui). this study aims to investigate the effects of home-based telerehabilitation-assisted high-intensity inspiratory muscle training (imt) on pfm function and urinary symptoms in women with sui.

the imt protocol consisted of home-based high-intensity daily training - two cycles of 30 breaths with a 1-minute rest between sets, twice a day for 8 weeks using an imt threshold device (threshold imt philips® respironics, inc). the imt was performed twice a day, 7 days/week, for 8 weeks. the study group performed imt at 60% of their baseline mip and was adjusted weekly based on the modified borg scale from 4 to 6 regarding respiratory effort performed during the session, while the control group performed a sham-imt without applied resistance. patients are evaluated before the inspiratory muscle training and after 8 weeks of training.

Eligibility criteria:
inclusion criteria: * diagnosed with stress urinary incontinence by a specialized urologist * being female aged between 25 and 50 years * to have the ability to access and use technological devices required by the study * being able to read and write * volunteering to research exclusion criteria: * inability of the participant to understand or perform the procedures proposed during the evaluations or training program. * active urinary tract infection, * pelvic organ prolapse stage 2 and more according to the pelvic organ prolapse staging system (pelvic organ prolapse quantification system (pop-q)) * fecal incontinence, * any neurogenic dysfunction of the lower urinary tract * conservative or surgical treatment of urinary incontinence in the last 12 months * previous pelvic floor training * less than three months after pregnancy or postpartum * having undergone any pelvic floor surgery (hysterectomy, etc.) * radiotherapy treatment in the last 12 months * severe low back pain or pelvic pain * lower extremity orthopaedic problems that may affect the pelvic structure (such as lower extremity inequality, total hip arthroplasty) * having any chronic respiratory disease * having any neurological disease * being in menopause * latex allergy

Keywords: inspiratory muscle training stress urinary incontinence pelvic floor muscle telerehabilitation
normal and pathological values of postvoiding residual volume in early postpartum period and their predisposing factors

Conditions: Urinary Retention

Summary: aim of this study is to asses post voiding residual volume by ultrasound scan 3th day after delivery with consecutive scan after 6 weeks, and determination of data dispersion among the population of primiparas. in women with excessive retention (+2sd), risk factors such as duration of labour, use of epidural analgesia, instrumental delivery, maternal birth injury and weight of the newborn will be noted down.

pregnancy itself and vaginal delivery are well known risk factors for pelvic floor dysfunction. the rise in progesterone related to pregnancy has an inhibitory effect on bladder smooth muscle - decreased smooth muscle tonus in lower urinary tract. weight and pressure of pregnant uterus and loosening of some of the pelvic ligaments changes the statics of pelvic floor. in addition, delivery itself influence lower urinary tract; an overdistension of urinary bladder can occur easily, also as oedema of urethra or urethral hinge apparatus injury during "crowning" of the fetal head. all of these factors can affect consecutive function of lower urinary tract right after delivery. it is known that in 1,5% of women giving birth, symptomatic urinary retention develop in early postpartum period, with necessity of insertion of an indwelling catheter. discussed risk factors are: epidural analgesia, instrumental delivery and primiparity. the investigators can assume that every woman in early postpartum period has (to some extend) even in normal circumstances postvoiding residual volume. there is few evidence in a literature about this postpartum residual volume and its predisposing factors. postvoiding residual volume can be risk factor for postpartum urinary infection, which forms second largest part in infectious morbidity of women. by determination of risk factors (for increased post voiding residual volume) the investigators could narrow the group of women which necessitate increased attention in postpartal monitoring.

Eligibility criteria:
inclusion criteria: * the investigators involve every primipara giving birth at 2nd department of obstetrics and gynecology, university hospital bratislava and comenius university, bratislava, slovak republic in a period of two years exclusion criteria: * unwilling to participate * minors (under 18 years old) * foetus mortus or perinatal death of the newborn * admission of the newborn to the icu * unfamiliar with slovak language * multiple pregnancy

Keywords: postvoiding residual volume early postpartum period
ozone injection for shoulder impengement syndrome

Conditions: Research on the Effectiveness of a Corticosteroid, Single Dose and Three Doses of Ozone Injection in Shoulder Impingement Syndrome

Summary: ozone injection has lately been utilized as a safe alternative to corticosteroids in the management of musculoskeletal diseases with fewer side effects. this study aimed to compare the effectiveness of a corticosteroid, single dose and three doses of ozone injection in shoulder impingement syndrome (sis).

a hundred and eight sis patients were divided into three groups and underwent subacromial injections in this prospective study. group 1 received a single dose (n:36), group 2 (n:36) received three doses of ozone injection (n :36). group 3 (n:36) was treated with a corticosteroid injection. patients were evaluated using the visual analog scale (vas) and constant murley score (cms), pre-injection and at 4 weeks and 12 weeks.

Eligibility criteria:
inclusion criteria: patients older than 18 years with shoulder pain lasting for more than three months, pain severity more than 5/10 on visual analog scale (vas), and diagnosed with sis according to clinical examination and magnetic resonance imaging (mri), were enrolled in this randomized clinical study. - exclusion criteria: the exclusion criteria were as follows: existing pathological abnormalities such as full-thickness rotator cuff tears on mri, any cause of shoulder pain other than sis such as inflammatory joint diseases, shoulder osteoarthritis and adhesive capsulitis, restriction of shoulder range of motion, coagulation disorders or use of anticoagulants, previous history of shoulder trauma, surgery or fracture, history of any subacromial injection or physical therapy for the last year, contraindications for ozone injection such as known glucose 6 phosphate dehydrogenase deficiency, pregnancy, uncontrolled hyperthyroidism, and leukemia. -
sinus balloon dilation in pediatric patients

Conditions: Sinusitis

Summary: safety and effectiveness of sinus balloon dilation in patients 2-21 years old.


Eligibility criteria:
inclusion criteria: patients age ≥ 2 to ≤ 21 years old. diagnosed with chronic rhinosinusitis (crs). candidate for trans-nasal balloon sinus dilation. exclusion criteria: history of sinus surgery. recent nasal or head and neck surgery. fungal sinus disease. severe asthma. cystic fibrosis. immunodeficiency. craniofacial abnormalities. pregnancy (current)

Keywords: sinus infections sinusitis chronic sinusitis rhinosinusitis allergic sinusitis allergic rhinitis chronic rhinosinusitis sinus disease in children sinus balloon dilation balloon dilatation sinus disease pediatric