Kornimate/medical-research-clean huggingface dataset:
the effect of dietary fiber-enriched cereals on glycemic control and secretion of gut hormones

Conditions: Diabetes Mellitus

Summary: the aim of this study is to assess whether dietary fiber-enriched cereals effect on postprandial glucose levels and plasma glucagon-like peptide 1 (glp-1) and/or glucose-dependent insulinotropic polypeptide (gip) concentration in patients with type 2 diabetes mellitus.

fifteen subjects with type 2 diabetes mellitus will be provided with study meals based on either dietary fiber-enriched cereals or conventional cereals upon two separate admissions in a cross-over fashion. the study meals will be provided at 6 p.m. and 10 p.m. on the day of admission, and 8 a.m. on the next day. a hamburger with coke as mixed meal will be given for lunch at noon on the second day. blood sampling will be done every 30 minutes from 8 a.m. to 4 p.m. on the second day. the plasma levels of glucose, glp-1, gip, insulin, glucagon, and free fatty acid will be measured.

Eligibility criteria:
inclusion criteria: * type 2 diabetes mellitus * hba1c 6.5\~8.5% * on life style modification or metformin monotherapy at the time of screening exclusion criteria: * on sulfonylurea or insulin therapy at the time of screening * allergy to wheat, flour, other cereals or nuts * lactose intolerance * pregnancy / lactation

Keywords: dietary fiber diabetes mellitus gut hormone
interferential current therapy after total knee arthroplasty

Conditions: Total Knee Arthroplasty

Summary: interferential current is widely used as a popular treatment in painful musculoskeletal disorders. and total knee arthroplasty patients present with extreme pain immediately after surgery. so this study is aimed to investigate the effectiveness of interferential current implementation following total knee arthroplasty surgery. in this study interferential current compared with sham interferential current . patients were assessed with pain, range of motion , edema and the amount of used paracetamol.

a total of 132 patients ranging in 60-85 years who were undergoing their first total knee arthroplasty due to knee oa were recruited into a randomized, double-blind, prospective and controlled study. participants were recruited at the orthopedics and traumatology inpatient clinic. the patients were seen postoperative first day and were assigned to receive either interferential current or sham interferential current by block randomization. after the procedure was explained to each subject, interferential current treatment was applied 2 times for 5 days, each treatment was continued approximately 30 minutes. four electrodes were used to deliver quadripolar interferential current subjects were told that in order to produce an effect, the intensity of the stimulator must be maintained at a "strong but comfortable level" at all times. the sham interferential current treatment consisted of the placement of the same pads for the same time but no electrical stimulation was applied to the probes. at the same time, all patients received standard postoperatively rehabilitation program. patients were assessed with pain, range of motion , edema and the amount of used paracetamol.

Eligibility criteria:
inclusion criteria: •patients who underwent total knee arthroplasty surgery exclusion criteria: * patients who had experienced of any electrotherapy prior to the tka to be sure blinding of therapy * patients who had history of any contraindication for electrotherapy * patients who had chronic pain rather than knee oa * patients who had experienced a known or suspected joint infection or a specific condition (ie, peripheral or central nervous system lesions, neoplasm, diabetes mellitus, osteonecrosis, recent trauma and pacemaker) * patients who had history of stroke, central nervous disease, mental impairment or poor general health status that would interfere with functional assessments during the study

Keywords: pain surgery interferential current total knee arthroplasty
hemoglobin and inr out of nose blood

Conditions: Epistaxis

Summary: nose bleeding (epistaxis) is a common emergency. it is often difficult to estimate blood loss and the current hemoglobin of patients. in patients with oral anticoagulation, it is important to measure the level of hemodilution. several situations with the importance of the fast determination of these parameters have been identified in previous studies \[1,2\]. the blood sampling from the venous punction is the standard in these investigations. however, this requires the corresponding painful puncture and also the time required at the laboratory. since many patients present themselves with active bleeding, it is obvious that this blood could be used for determining the following parameters: hemoglobin and inr/quick. the nose blood can be analyzed with commercial rapid test devices. if these devices could generate same or similar results and after further validation of the method, painful punctures could be waived.

patients with active epistaxis are verbally elucidated about the study and the verbal consent is obtained. according to the agreement a few drops of nose blood are preserved. subsequently the standard therapy is performed. this blood sample is promptly analyzed with the rapid test devices. we successfully applied the exception to the analysis of blood samples prior to obtaining the written consent due to following reasons: analysis with the rapid test devices needs to be immediate and without delay in order to satisfy quality standards prescribed by the manufacturers. in addition, patient's treatment should not be delayed. simultaneously, a venous blood sample for the corresponding values is carried out according to medical indications. after the treatment of the acute emergency and thus after the greatest stress situation, we ask the patient again whether he agrees to the study conditions. the written consent is obtained in the end of the acute treatment. both inception and termination of the research project will be reported within 90 days of the ethics committee.

Eligibility criteria:
inclusion criteria: * patients with active nose bleeding * indication for routine blood sampling * aged 18 to 99 years * verbal informed consent before implementation takes place * written consent of the participating person after investigation and completion of treatment exclusion criteria: * no active bleeding * routine blood sampling for medical reasons not indicated * lack of understanding of the study or investigation
a study to evaluate the abuse potential of single oral doses of dimebon (latrepirdine) in healthy recreational polydrug users

Conditions: Alzheimer's Disease; Huntington's Disease

Summary: dimebon will not exhibit abuse potential when compared to placebo or a positive control (alprazolam).

the main purpose for this study is to determine whether dimebon exhibits abuse potential.

Eligibility criteria:
inclusion criteria: * healthy male and/or female subjects between the ages of 18 and 55 years. * recreational polydrug user with a history of cns depressant use. exclusion criteria: * history of clinically significant neurologic condition(s), such as seizures, convulsions, epilepsy, or significant head injury, as judged by the investigator or designee. * a known history of hypersensitivity or previous intolerance to dimebon or other antihistamines. * self-reported history of drug or alcohol dependence (except nicotine or caffeine) in the 2 years prior to screening, or drug or alcohol dependence as defined by the (dsm-iv-tr) in 12 months prior to screening, including subjects who have ever been in a substance rehabilitation program (other than treatment for smoking cessation). * history of clinically significant psychiatric disorder(s), as judged by the investigator or qualified designee.

Keywords: oral single-dose 6-way crossover recreational drug users abuse potential pharmacodynamics safety
objective assessment of behavioural disorders in pd

Conditions: Parkinson's Disease; Non-motor Symptoms

Summary: the aim of this project is to measure behavioural disorders in parkinson's disease (pd) patients in a more objective way, in order to facilitate the detection of those symptoms and improve the treatment of non-motor symptoms in parkinson's disease.

apathy and impulse control disorders (icds) are frequent non-motor symptoms of pd and negatively affect the quality of life of patients. although healthcare professionals have begun to understand the extent of the problem faced by those suffering apathy or icds, accurate diagnosis is still difficult, as behavioural symptoms are often multidimensional, develop gradually over the course of months and clinical staff have to rely on the self-report of the patient or the report of a family member to assess them. to overcome this issue, the investigators aim to use information and communication technologies to measure apathy and hyperdopaminergic behaviours in pd patients with stn-dbs in an objective way, with the ultimate goal of improving the management of pd patients with stn-dbs. to do so, the investigators will use three computer-based tasks that measure effort-based decision making and emotion processing in pd patients, and assess motor, cognitive and neuropsychiatric symptoms in parallel with scales and tests. in some select patients, motor symptoms and activity patterns will be monitored with an in-home sensor system before and after deep brain stimulation stn-dbs, and the above mentioned procedures will be repeated 4 months after stn-dbs.

Eligibility criteria:
inclusion criteria: * diagnosed with parkinson's disease. * (planned) stn-dbs. * able to understand instructions and provide informed consent. * native speaking or proficient french or german * montreal cognitive assessment (moca) with score ≥ 22 * ability to manipulate handheld dynamometers exclusion criteria: * disease affecting the brain other than parkinson's disease * suffering from or diagnosed with ongoing psychiatric illnesses * severe somatic illnesses leading to reduced life expectancy * severe physical disability leading to impairment in basic functional activities * participation in a pharmacological study * inability to provide informed consent (legal guardianship)

Keywords: parkinson's disease non-motor symptoms assessment of non-motor symptoms sensor monitoring behavioural disorders deep brain stimulation apathy impulse control disorder
physical exercise and diet management in vitamin d deficient females

Conditions: Vitamin D Deficiency

Summary: the purpose of this study was to determine if home based physical exercises protocol and diet management has an effect on functional performance and depression level related to vitamin d deficiency in females.

this is a randomized controlled trial to study the effect of home based physical exercises in comparison to diet management, sun exposure and vitamin d supplements on functional performance and depression level in females with vitamin d deficiency.

Eligibility criteria:
inclusion criteria: * subjects whose age ranged from 19-25 years. * all participants have pre laboratory results with vitamin d deficiency less than 25 nmol/l and have been lasted for 6 months * all participated subjects were female studying at al-jouf university, al- qurrayyat-female branch. exclusion criteria: * chronic illness, liver, renal endocrine or autoimmune diseases. * patients who suffered from any cardiopulmonary diseases. * history of fractures or any neuro-musculoskeletal disorders.
diagnosis of macrophage coronary plaque by optical tomographic imaging

Conditions: Atherosclerotic Plaque

Summary: this study evaluated optimal macrophage diagnosis algorithm through comparative analysis between coronary artery, oct image, and ivus, and improve a diagnosis rate of vulnerable coronary plaque accompanied with macrophage infiltration.


Eligibility criteria:
inclusion criteria: * age 18 and above * patients who are to receive heart transplantation * patients or their legal representatives who gave a prior written consent exclusion criteria: * impossible to oct and ivus analysis due to severe coronary stenosis

Keywords: macrophage vulnerable coronary plaque
pulsed electromagnetic fields for multiple chemical sensitivity

Conditions: Multiple Chemical Sensitivity

Summary: the purpose of this study is to determine whether pulsed electromagnetic fields(pemf) is effective in the treatment of multiple chemical sensitivity in terms of life impact, symptoms, psychological distress, markers of central sensitization and the immune system, and quality of life.


Eligibility criteria:
inclusion criteria: * lacour's criteria for multiple chemical sensitivity * lifestyle or functional impairments that score ≥ 35 on the life impact scale of the quick environmental exposure and sensitivity inventory * signed informed consent exclusion criteria: * previous pemf therapy * psychosis or a comparable disorder * epilepsy * cerebral tumours * leukaemia or malignancies in the head or neck region * having a pacemaker or other active implants * pregnancy or nursing * unreliable contraception * drug or alcohol abuse * a pending application or intentions to apply for early retirement * initiation of pharmacological treatment which have not steadied * participation in another research study

Keywords: multiple chemical sensitivity, re5 therapy, pulsed electromagnetic fields
promoting weight-loss in african american cancer survivors in the deep south

Conditions: Weight Loss; Cancer

Summary: this study tests evidence-based strategies for weight loss among overweight and obesity cancer survivors and family members in rural alabama.

this is a 3-arm cluster randomized controlled study that compares a trained lay provided weight loss program vs. the same program plus community-based weight management strategies vs. general cancer prevention education on weight loss and other clinical outcomes (primary outcomes) and healthy behaviors, and psychosocial functioning (secondary outcomes).

Eligibility criteria:
inclusion criteria: * african american breast, colon, or prostate cancer survivor (index participant) * family member (support person) of african american breast, colon, or prostate cancer survivor (family member participant) * live, work, or attend school in target county * bmi \>= 25 kg/m2 exclusion criteria: * pregnant or planning to become pregnant in the next year * known major medical or psychological condition known to influence body weight * uncontrolled hypertension (bp \> 160 mmhg systolic or \>100 mmhg diastolic) * medicated or poorly controlled diabetes (glucose \> 126) cardiovascular event in the preceding 12 months * history of gastric bypass or bariatric surgery * history of psychiatric hospitalization in past 2 years * history of substance abuse or eating disorder * any other condition by which a medical professional has suggested diet modification, physical activity and/or weight reduction would be contraindicated
extension of analgesia by combined injection of dexamethasone and dexmedetomidine after arthroscopic shoulder surgery

Conditions: Analgesia

Summary: the main objective of the study is to demonstrate the efficacy of dexmedetomidine on the prolongation of analgesia obtained by interscalenic bloc of the brachial plexus and intravenous injection of dexamethasone (efficacy objective).

this is an interventional, comparative, randomized, controlled study versus reference treatment, in 2 parallel groups, double blind (patient and evaluator), multicenter, aiming to demonstrate the superiority of this is an interventional, comparative, randomized, controlled study versus reference treatment, in 2 parallel groups, double blind (patient and evaluator), multicenter, aiming to demonstrate the superiority of dexmedetomidine over the absence of dexmedetomidine, in adjuvantation of a loco regional anesthesia (interscalenic bloc of the brachial plexus + intravenous injection of dexamethasone), on the prolongation of the analgesia, following a surgery of the rotator cuff of the shoulder under arthroscopy. patients will be randomized into 2 groups according to the treatment received: * dexmedetomidine; * nothing (control arm). the investigator (anesthesiologist) who will perform the randomization will not be blinded to the treatment.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years; * patient undergoing arthroscopic shoulder surgery to repair the rotator cuff tendons; * patient capable of understanding the information related to the study, of reading the information leaflet and agreeing to sign the consent form. exclusion criteria: * patient on oral morphines before surgery; * contraindication to performing a general anesthesia associated with a shoulder loco regional anesthesia in a single injection; * contraindication to take oral morphines; * any non-arthroscopic repair (intraoperative conversion to "open sky" technique); * any other loco regional anesthesia than an interscalenic block (change of intraoperative strategy); * pregnant or lactating woman; * intolerance or allergy or contraindication to one of the treatments under study; * patient participating in another clinical trial, or in a period of exclusion from another clinical trial.
blood, hair and lung concentrations of metals and metalloids in patients with lung cancer or chronic obstructive pulmonary disease

Conditions: Lung Cancer; Chronic Obstructive Pulmonary Disease; Emphysema; Lung Surgery

Summary: prospective research to study the relationship between concentrations of metals/metalloids in blood, hair and lung tissue with the occurence of lung cancer or chronic obstructive pulmonary disease.


Eligibility criteria:
inclusion criteria: * patients of 18 to 75 years of age. * patients admitted for lung resection (either cancerous or non-cancerous) or lung transplant exclusion criteria: * patients with mental or physical conditions that prevent them giving their agreement for the study

Keywords: metals metalloids blood hair lung lung cancer chronic obstructive pulmonary disease
strengthening exercises versus proprioception and balance exercises in the treatment of knee osteoarthritis

Conditions: Osteo Arthritis Knee; Pain

Summary: the aim of the study is to investigate and compare the effect of balance and proprioception exercises with strengthening exercises on muscle strength, pain, proprioception, function and quality of life in knee osteoarthritis patients.

damage or loss of mechanoreceptors in osteoarthritis patients affects balance and proprioception. there are studies showing that proprioceptive deficit is associated with the onset and progression of knee osteoarthritis leading to pain and disability. because the proprioception provides a sense of power generation and allows the power output to be better regulated. when the literature is examined, studies investigating the effects of proprioception and balance exercises on muscle strength, function and pain are limited. in our study patients will be randomly divided into two groups: group i (proprioception and balance) and group ii (muscle strengthening exercises). while group i will be applied proprioception and balance training exercises, group ii will be applied closed and open kinetic strengthening exercises. two group will perform exercise 3 times a week during 8 weeks.

Eligibility criteria:
inclusion criteria: * patients who have a diagnosis of knee osteoarthritis according to the american society of rheumatology (acr) criteria, * between 45 to 75 years of age * can read and write in turkish language exclusion criteria: * active synovitis * taking any physical therapy section in the last 6 months * have a neurological problems that affect walking * have an arthritis problem in the ankle and hip joint * have a history of lower extremity surgery * intraarticular steroid injection in the last 6 months * use psychoactive drug * have a severe defect of vision and hearing, speech disorders * vestibular dysfunction

Keywords: rehabilitation pain functionality proprioception
cost effectiveness of sunitinib in central america and caribbean

Conditions: Metastatic Renal Cell Carcinoma

Summary: primary hypothesis: the therapy with sunitinib represents better cost-effectiveness than ifn-α in first-line treatment for metastatic renal cell carcinoma (mrcc) in central america and caribbean countries

this study was terminated on 03feb2011 due to the fact that the anticipated number of patients expected was not reached. the date of cessation of the drug was january 27, 2011. there was no intervention in the treatment or administration of the drug; the study only observed the treatment and collected data. as the study was dependent on the arrival of new patients with metastatic renal cancer, which was of a very low incidence, the study was terminated. efficacy, adverse events or other safety issues were not factors in terminating the study. lack of patients was the only reason.

Eligibility criteria:
inclusion criteria: * evidence of a personally signed (or legally acceptable representative) and dated informed consent document indicating that the subject (or a legally acceptable representative) has been informed of all pertinent aspects of the study. * adult (18 years old or older) men and women with confirmed diagnosis of mrcc treated with sutent, ifn-α or bevacizumab + ifn ; on the selected institutions. exclusion criteria: * adult men or women with rccm treated with any other medication that is not sutent, ifn-α or bevacizumab + ifn. * adult men or women with mrcc with palliative care. * adult men or women with rcc without metastasis.

Keywords: cost effectiveness sunitinib central america and caribbean metastatic renal cell carcinoma
effect of calcium supplement particle size and vitamin d supplement on calcium retention in adolescent girls

Conditions: Osteoporosis

Summary: this study has two research arms: the purpose of the 1st is to determine if a smaller particle size calcium carbonate supplement (than that which is now commercially available) improves calcium absorption and retention in adolescents girls. the purpose of the 2nd is to determine if vitamin d supplementation improves calcium absorption and retention in adolescents girls.

an important strategy to reducing the risk for osteoporosis and fracture in later life is to optimize the development of peak bone mass during adolescence. because calcium is the main mineral component of bone, maximizing calcium absorption and retention during adolescence is important to maximize peak bone mass. our two research arms address two different mechanisms by which calcium absorption and retention may be increased: 1. we hypothesize that a smaller particle size calcium carbonate supplement (than that which is now commercially available) may be better absorbed and lead to higher calcium retention in adolescents. 2. we hypothesize that vitamin d supplementation will increased calcium absorption and retention in adolescents. subjects will be assigned to one of the two research arms. 1)small and large particle size calcium supplements or placebo or 2) calcium supplements with or without vitamin d supplements will be given to subjects during two 3-week study periods in which subjects live on-site. calcium absorption will be measured by parathyroid hormone suppression after a calcium load and by stable calcium isotope in some subjects. calcium retention will be measured by calcium intake minus calcium excretion.

Eligibility criteria:
inclusion criteria: * 12-14 year old girls * generally healthy exclusion criteria: * history of alcohol, smoking, or non-prescription drug use * malabsorptive disorders, bone, liver, or kidney disease that may affect calcium metabolism * oral contraceptive use * pregnancy

Keywords: calcium vitamin d particle size adolescents bone osteoporosis