Kornimate/medical-research-clean huggingface dataset:
effect of a calisthenic exercises on premenstrual symptoms

Conditions: Menstrual Pain

Summary: the aim of this study is to examine the effects of an eight-week calisthenic home exercise program on premenstrual symptoms, pain and sleep quality in young women.

the study was conducted on 30 volunteers who met the inclusion criteria among female students studying at haliç university faculty of health sciences. the "premenstrual syndrome scale (pmss)" was used to assess the individuals' premenstrual symptoms; the "visual analog scale (vas)" was used to assess pain for each of the abdominal, lumbar and general body pain; and the "pittsburgh sleep quality index (psqi)" was used to assess sleep quality. then, the participants were randomly divided into two groups as "group 1: control group (n=15)" and "group 2: - calisthenic home exercise group (n=15)". participants in the first group were not subjected to any intervention and were asked not to participate in any exercise program for eight weeks. participants in the second group were informed about calisthenic home exercise programs face to face and were asked to perform these exercises as home exercises for eight weeks. at the end of the treatment process, participants' pmss, vas and psqi scores were re-evaluated.statistical analysis will be performed with spss 24.0 program. if the data is parametric, paired sample t-test will be used for within-group evaluation; independent sample t-test will be used for between-group evaluation. if the data is non-parametric, wilson test will be used for within-group evaluation and mann whitney u test will be used for between-group evaluation.

Eligibility criteria:
inclusion criteria: * being a woman between the ages of 18-25 * studying at halic university faculty of health sciences * voluntarily participating in the study * having a normal menstrual cycle * not exercising * having a score above the mild level on the premenstrual syndrome scale exclusion criteria: * having a condition that prevents exercise * pregnancy * menopause * having a gynecological disease (endometriosis, ovarian cyst, pelvic infection, myoma/uterine tumor, etc.)
comparison of immunogenicity and safety of inactivated and live attenuated hepatitis a vaccines in young adults

Conditions: Hepatitis A

Summary: a phase iv, randomization, single center, controlled clinical trial to compare the safety, immunogenicity,three-year immune persistence of inactivated hepatitis a vaccine (hav) with one- or two-dose regimen and live attenuated hav with one-dose regimen in chinese young adults, and to evaluate the immunogenicity of a booster dose.

healthy undergraduate students aged 16 to 25 years with anti-hav negative were randomly divided into three groups. group a and b were administrated with one-dose inactivated and live attenuated hepatitis a vaccines respectively; group c was immunized with two doses of an inactivated vaccine with 6 months apart. blood samples were collected at month 1, and 12, 24 and 36 for anti-hav titers determination. safety observation in 30 minutes' duration after vaccinations and injection-site reactions and systemic reactions for three consecutive days were recorded to assess the safety of investigational vaccines. at month 36, subjects who received one dose of inactivated or live attenuated hav were administrated a booster dose and then were taken blood samples one month later for anti-hav titers determination.

Eligibility criteria:
inclusion criteria: * healthy undergraduate students aged 16 to 25 years * sign the informed consent * provide id exclusion criteria: * axillary temperature \> 37.0 centigrade at the time of dosing * subject that has a medical history of any of the following: allergic history, or allergic to any ingredient of vaccine * serious adverse reactions to vaccines such as anaphylaxis, hives, respiratory difficulty, angioedema, or abdominal pain * autoimmune disease or immunodeficiency * congenital malformation, developmental disorders or serious chronic diseases (such as down's syndrome, diabetes, sickle cell anemia or neurological disorders) * bleeding disorder diagnosed by a doctor (e.g. factor deficiency, coagulopathy, or platelet disorder requiring special precautions) or significant bruising or bleeding difficulties with im injections or blood draws * history or family history of convulsions, epilepsy, brain disease and psychiatric * history of any blood products within 3 months * administration of any other investigational research agents within 30 days * administration of any live attenuated vaccine within 30 days * administration of subunit or inactivated vaccines within 14 days * any medical, psychiatric, social condition, occupational reason or other responsibility that, in the judgment of the investigator, is a contraindication to protocol participation or impairs a volunteer's ability to give informed consent * anti-hbsag positive * anti-hav positive * pregnancy test result is positive

Keywords: inactivated hav vaccine; live attenuated hav vaccine; immunogenicity; safety
remote ischemic preconditioning and contrast induced - acute kidney injury in patients undergoing elective pci

Conditions: Remote Ischemic Preconditioning; Contrast Induced - Acute Kidney Injury

Summary: prospective, randomized, sham-controlled clinical study was conducted to assess whether ripc reduces the incidence of ci-aki measured standard way of using scr concentration but also with the use of serum ngal as a new potential biomarker of kidney injury. furthermore, the aim of investigation was to analyse the safety and clinical outcomes of ripc after elective coronary angiography (ca) followed by percutaneous coronary intervention (pci).

nowadays ci-aki is defined according to serum creatinine concentration (scr) as any of the following: (1) an absolute rise of ≥ 0.5 mg/dl (44 µmol/l) and/or (2) a relative increase of 25% in serum creatinine compared to baseline within 48 to 72 hours after contrast administration. in the last decades, several novel biomarkers of aki have been studied including neutrophil gelatinase-associated lipocalin (ngal). furthermore, remote ischemic preconditioning (ripc) turned out to be one of the most promising and intriguing non-pharmacological strategy. this simple procedure consisting of brief, non-lethal episodes of ischemia and reperfusion applied in one tissue or organ protects remote tissues or organs from subsequent injury.

Eligibility criteria:
inclusion criteria: * aged over 18 years * patients with stable angina pectoris * patients admitted to intensive cardiac therapy clinic medical university of lodz with intention of elective ca with follow-up pci. exclusion criteria: * history of severe injuries up to 2 months before intervention * history of surgeries up to 2 months before intervention * history of cancer, * acute inflammation during hospitalization * chronic autoimmunologic diseases * patients needing hemodialysis * chronic kidney disease in stage 4 or 5 (egfr\<30 ml/min/1,73m2) * peripheral vascular disease affecting upper limbs.

Keywords: remote ischemic preconditioning contrast induced-acute kidney injury neutrophil gelatinase-associated lipocalin percutaneous coronary intervention
pelvic floor function after obstetric injury to the anal sphincter

Conditions: Obstetric Anal Sphincter Injury; Anal Incontinence; Urinary Incontinence; Sexual Dysfunction

Summary: the goal of this observational study is to learn more about the effect a pregnancy and delivery has on the function of the anal musculature.we will compare women who had a new delivery after suffering a severe tear in the anal musculature in their first pregnancy, with women who had two or more vaginal deliveries, but did not suffer such an injury. the main questions we want to answer is: * can the burden of a new pregnancy and delivery weaken the function of the repaired musculature in a way that might cause symptoms of anal incontinence later in life? * can a tear in the anal musculature increase the risk of developing urinary incontinence and long term sexual dysfunction? * should we recommend these women to have a caesarian section instead of a new vaginal delivery? participants will be asked to complete an electronic questionnaire with information regarding their pregnancies, deliveries and potential symptoms from anal incontinence, urinary incontinence and sexual dysfunction. researchers will compare these two groups to find out if a new vaginal delivery has a negative effect on the function of the anal musculature.


Eligibility criteria:
inclusion criteria: * sphincter group: previous obstetric anal sphincter injury during vaginal childbirth in 2002-2018 and having a subsequent vaginal delivery without such injury * control group: two or more vaginal deliveries without obstetric anal sphincter injury exclusion criteria: * under 18 years * consent incompetency * obstetric anal sphincter injury in subsequent pregnancies * caesarian section in subsequent pregnancy
preservation of ovarian function after hematopoietic cell transplant

Conditions: Multiple Myeloma; Non-Hodgkin Lymphoma; Hodgkin Disease; Acute Myeloid Leukemia; Myeloproliferative Disorders

Summary: women undergoing myeloablative allogeneic hematopoietic cell transplant (ma hct) will receive gnrh agonist leuprolide. women undergoing reduced intensity allogeneic (ric) hct will be observed.

this study is to use gonadotropin releasing hormone (gnrh) agonist leuprolide prior myeloablative hematopoietic cell transplantation to prevent ovarian dysfunction in post-menarchal women. the primary objective is to determine the effect of gnrh agonists on the incidence of ovarian failure. the secondary objectives are * to determine how effective gnrh agonists are at suppressing menses during * to determine the incidence and timing of resumption of menstrual cycles after hct * to determine the incidence and timing of resumption of normal fsh and lh levels after hct * to determine the incidence of normal amh levels after hct * to determine the effect of gnrh agonists on immune reconstitution after hct * to assess the safety and tolerability of gnrh agonists in the context of hct a total of 47 patients will be accrued in this study.

Eligibility criteria:
inclusion criteria: * interventional arm: * eligible for myeloablative allogenic or autologous hematopoietic cell transplant (hct) * post-menarchal female \< or = 50 years of age * normal antimullerian hormone (amh) level and/or follicle stimulating hormone (fsh)/leuprolide (lh) levels for age/stage of puberty * those women who have an fsh \> 40 iu/l and whose diagnosis of malignancy and whose chemotherapy treatment was within 12 weeks of enrollment are still eligible if they had normal menstrual cycles pre-diagnosis. * observational arm: * eligible for reduced intensity allogeneic hct * post-menarchal female ≤ 50 years of age * normal amh level and/or fsh/lh for age/stage of puberty * those women who an fsh \>40 iu/l and whose diagnosis of malignancy and chemotherapy treatment was within 12 weeks of enrollment are still eligible if they had normal menstrual cycles pre-diagnosis. exclusion criteria: * all arms: * history of ovarian cancer * surgical resection of one or both ovaries. prior hysterectomy is allowed as long as the ovaries are intact. * use of gnrh agonist in last 12 months will exclude patients if lab results are not available to demonstrate adequate ovarian function prior to initiation of gnrh therapy.

Keywords: post-menarchal
flexibility, range of motion and strength among patients with differing response to the scapular and humeral assistance tests

Conditions: Shoulder Pain

Summary: shoulder pain may result from abnormal arm or shoulder blade (scapular) movement. these abnormal movements may result from a variety of flexibilty, motion or strength impairments. therefore identifying any abnormal arm or scapular movement, as well as any impairments that are associated with them can help clinicians plan a proper management strategy for patients presenting with shoulder disorders. our hypothesis is that specific impairments will be associated with abnormal arm movement, while other impairments will be associated with abnormal scapular movement among patients with shoulder pain.


Eligibility criteria:
inclusion criteria: * age 18 years or older, main complaint of shoulder pain, ability to elevate arm in the scapular plane to at least 135 degrees, pain during scapular plane elevation, can read hebrew. exclusion criteria: * signs or symptoms suggesting cervical spine origin, previous fracture around shoulder complex, traumatic onset of shoulder pain, fibromyalgia, rheumatiod arthritis, previous shoulder surgery, loss of 50% or more of passive range of motion in 2 or more planes of motion, positive lag signs, positive apprehension test, pregnancy.

Keywords: shoulder pain, scapular dyskinesia, physical examination
continuous hemofiltration during cardiopulmonary bypass and its effect on lactatemia

Conditions: Cardiovascular Diseases

Summary: this study aims to analyze the impact of using polysulfone membranes on continuous ultrafiltration with volume replacement in patients undergoing cardiac surgery. in this type of surgery, techniques such as conventional ultrafiltration (cuf) and modified ultrafiltration (muf) are known for controlling the patient's fluid balance during the procedure. however, there is no scientific evidence on the benefits of continuous haemofiltration with volume replacement and its effect on lactatemia. method and design: a single center randomized controlled trial, parallel treatment design with patient-blinded to compare outcomes in terms of the lactate clearance rates (quantity/unit of time) of the assigned therapy groups. participants will be randomly assigned to receive the type of surgery, in order to ensure an unbiased assessment of treatments, randomisation will be performed in eight blocks of five patients. the study groups will be equivalent in all aspects except the procedures they undergo. participants will be assigned to the first control group without haemofiltration (cg or 1) or one group with haemofiltration using a polysulfone filter (pg or 2). data will be collected by a blinded evaluator.

to determine whether continuous ultrafiltration with volume replacement using a polysulfone membrane during cardiopulmonary bypass (cpb) in patients undergoing cardiac surgery decreases intraoperative lactatemia.

Eligibility criteria:
inclusion criteria: * patients who signed informed consent * patients not undergoing emergency surgery. * surgical procedures performed under normothermic conditions. * patients with a minimum time of 40 minutes before decannulation (after the end of myocardial reperfusion, unclamping of the aorta and the end of cpb). exclusion criteria: * emergency medical condition in which it is not possible to collect study data. * heart condition requiring the use of hypothermia or hyperthermia during cpb. * patients without a minimum time of 40 minutes before decannulation (after the end of myocardial reperfusion, unclamping of the aorta and the end of cpb). * patients who cannot manage their fluid balance on their own through diuresis prior to cpb. * patients who are unable to manage excess volume during the surgical procedure by means of spontaneous or forced diuresis with diuretics (positive cumulative balance despite intravenous bolus of diuretics after 75% of the anticipated duration of cpb according to the course of the surgery).
high versus low target mean arterial pressure in septic shock in critically ill cirrhotics

Conditions: Cirrhosis

Summary: study design: * a randomized controlled study. * the study will be conducted on patients admitted to department of hepatology from april 2017 to october 2017 at ilbs, new delhi * study group will comprise of patients critically ill cirrhotics with septic shock all included patients would be randomised to low target map group (60-65mm hg) or high target group (80-85 mm of hg). patients older than 18 years of age will be enrolled if they have septic shock that is refractory to fluid resuscitation and if they required vasopressors (norepinephrine or epinephrine or terlipressin) at a minimum infusion rate of 0.1 μg per kilogram per minute. standard criteria will be considered to define refractoriness to fluids. the target map would be maintained for a max. of 5 days or until recovery or shock and or aki. in the high-target group, a reduction in vasopressor doses to maintain a mean arterial pressure of 65 to 70 mm hg will be done in case of any of the prespecified serious adverse events that could potentially be related to an increased rate of vasopressor infusion occurred. these events could be: clinically relevant bleeding (i.e., transfusion requirements of at least 2 units of packed red cells), myocardial infarction (defined as typical electrocardiographic changes, with a concomitant increase in troponin, and segmental echocardiographic hypokinesia or akinesia, with the infarction confirmed, when possible, by means of coronary angiography), major ventricular arrhythmia, poorly tolerated supraventricular arrhythmia, mesenteric ischemia, and distal-limb ischemia. • septic shock would be defined as clinical construct of sepsis with persisting hypotension requiring vasopressors to maintain map\>=65 mm of hg and having a serum lactate \>2 mmol/l despite adequate volume resuscitation


Eligibility criteria:
inclusion criteria: * critically ill cirrhotics with septic shock exclusion criteria: * patients with age less than 18 years * severe known cardiopulmonary disease (structural or valvular heart disease, coronary artery disease, copd) * pregnancy * chronic kidney disease on hemodialysis * extremely moribund patients with an expected life expectancy of less than 24 hours * failure to give informed consent from family members. * hemodynamic instability requiring very high dose of vasopressors
fourier transform of videokeratography data: clinical usefulness in moderate and frome fruste keratoconus

Conditions: Keratoconus

Summary: primary objective of this study was evaluate the diagnostic capacity of fourier analysis of keratometric data in differentiating moderate kc and ffk from healthy corneas. study participants were recruited from the cornea outpatient service in a consecutive if eligible basis. two study groups were formed: a)kc group included patients those were diagnosed and classified for moderate keratoconus according to the amsler-krumeich classification system, b) ffk group (ffkg) that included patients diagnosed with ffk, and c) control group (cg) was formed by refractive surgery candidates. pentacam (pentacam hr, oculus optikgerate gmbh, heidelberg, germany)measurements were performed by the same experienced operator in a consistent way.


Eligibility criteria:
inclusion criteria: * diagnosis of keratoconus kc in the fellow eye according to the amsler-krumleich criteria (ffkg) * kisa index between 60 and 100% in the ffk eye (ffkg) * lack of any kc-related findings / signs in the slit-lamp biomicroscopy (ffkg) * uneventful ophthalmologic history (cg) * no indications of corneal pathology in slit-lamp biomicroscopy and placido \*disk-based videokeratography (cg) * kisa index value less than 60% (cg) * diagnosed and classified for moderate keratoconus according to the amsler-krumeich classification system (kcg) exclusion criteria: * for all study groups: * previous incisional eye surgery * corneal scars and opacities * history of herpetic keratitis, severe eye dryness * pregnancy or nursing * current corneal infection * glaucoma * suspicion for glaucoma * iop lowering treatment * underlying autoimmune disease

Keywords: keratoconus, corneal crosslinking, fourier analysis of topographic data
efficacy of preoperative prehabilitation with a home-based supervised exercise program against an unsupervised exercise program for frail elderly patients undergoing major abdominal surgery

Conditions: Frail Elderly Syndrome; Frailty; Surgery

Summary: singapore's population is ageing, and more elderly people are undergoing elective major surgeries. frail elderly experience greater functional decline and slower recovery in physical function after surgery compared to non-frail elderly. preoperative prehabilitation aims to enhance both aerobic capacity and physical strength of elderly to attenuate the post-operative decline in physical function. singapore general hospital has a bespoke preoperative program - prehabilitation for elderly frail patients undergoing elective surgeries (prepare), where patients receive physiotherapy education and instructions for home-based unsupervised exercise program (usep). a hospital-based supervised exercise program had also been established but the take-up rate was low (7.6%) due to barriers such as cost and accessibility. perioperative supervised exercise training can effect greater gains in functional capacity and muscle strength compared to no supervision. for the elderly with limited transport options to the hospital, home-based supervised programmes may be more convenient compared to hospital-based supervised programmes, but the former is costlier too. home-interventions may also empower patients with the skills and confidence to maintain their physical fitness at home, which increases their likelihood of exercising after surgery. the investigators propose a prospective single-center randomized controlled trial to evaluate the efficacy of preoperative prehabilitation with a home-based supervised exercise program (sep) for frail elderly patients undergoing major abdominal surgery, compared to the mainstay of clinical practice, which is a home-based usep.


Eligibility criteria:
inclusion criteria: * 1. elective major abdominal surgery * 2. lead time \>= 14 days to surgery * 3. edmonton frail scale total score \>= 6 points or functional performance score (timed up and go(tug)) \>= 1 point exclusion criteria: * 1. inability to provide written informed consent due to cognitive impairment * 2. having comorbid medical conditions interfering with the ability to perform exercise at home or to complete the testing procedures. these include: i. unstable cardiac conditions ii. acute illnesses iii. patients who are completely unable to walk

Keywords: prehabilitation