Kornimate/medical-research-clean huggingface dataset:
investigating cytokine genes of stem cell donors

Conditions: Stem Cell Transplantation

Summary: this study seeks to investigate the factors that may account for the differences in the way a stem cell recipient s immune system works after a transplant. it will focus on cytokine genes, which give specific instructions to the genes and which may influence immune system response. more specifically, the purpose of the study is to find out how gene polymorphisms (gene variations among the population) affect the success or failure of a stem cell transplant. study participants will have donated blood for a stem cell transplant. they will be asked to give consent for nih personnel to run special tests on these blood samples, which will have been placed in storage. it is hoped that blood samples will be studied from 600 stem cell donors.

the nhlbi stem cell allotransplantation program is researching methods to improve allogeneic stem cell transplantation. we are particularly interested in identifying factors, which result in individual variability in outcomes. cytokines are biological modulators of the immune system known to influence various phases of the immune response. normal variations in the genetic material coding for cytokines (cytokine gene polymorphisms or cgps) are believed to account for some of the differences in the inflammatory response between individuals. in the future, we hope to tailor stem cell transplantation to take into account these immunological profiles. in order to characterize the effect of any such intervention, we first need to better understand the role cgps play in immune responses in normal, healthy persons. this involves testing for the presence or absence of a polymorphism in healthy individuals, and comparing with a validated in vitro assay. none of these polymorphisms are associated with known clinical disease to be classifiable as a 'genetic defect'. moreover, we will not correlate these polymorphisms with clinical studies to identify traits in the sample donors. we plan to utilize stored blood samples from stem cell transplant donors who have previously participated on a hematology branch protocol as well as consent future donors.

Eligibility criteria:
* inclusion criteria: participation as a stem cell donor on a hematology branch protocol. for adults: ability to comprehend the investigational nature of the study and provide informed consent. for minors: written informed consent from one parent or guardian. informed assent from minors: the process will be explained to the minor on a level of complexity appropriate for their age and ability to comprehend. age greater than or equal to 2 and less than or equal to 80. exclusion criteria: subjects unable to comprehend the investigational nature of the laboratory research.

Keywords: tumor necrosis factor alpha (tnf-alpha) interferon-gamma (ifn-gamma) interleukin-10 (il-10) interleukin-6 (il-6) interleukin-1 (il-1 ra) interleukin-1 receptor antagonist (il-1 ra) vitamin d receptor (vitd r)
waist circumference in cardiac surgery

Conditions: Obesity, Abdominal

Summary: metabolic syndrome including increased body mass index or waist circumference is known to be a risk factor of cardiovascular disease. however, the relationship between body mass index or waist circumference and clinical outcome after cardiac surgery has not been fully elucidated.

along with body mass index, which is determined with height and weight, waist circumference reflects abdominal obesity and may increase cardio-metabolic risk and all-cause morbidity/mortality. in this observational study, we will review the electronic medical records of patients underwent cardiac surgery and assess their waist circumference, measured on preoperative computed tomography, as well as body mass index. the relationship between body mass index or waist circumference and mortality after cardiac surgery will be analysed.

Eligibility criteria:
inclusion criteria: * patients undergoing cardiac surgery between 2004 and 2016 at seoul national university hospital exclusion criteria: * patients without information on height, weight, or waist circumference from abdominal computed tomography

Keywords: waist circumference body mass index cardiac surgery mortality
validation and turkish cross-cultural adaptation of stroke knowledge test

Conditions: Stroke; Hypertension

Summary: cerebrovascular diseases are the leading cause of disability, work loss, and quality of life reduction, the third leading cause of death globally, and significantly impact hospital admissions and expenses. this prevalence rises with an aging population and comorbidities. recognizing stroke symptoms quickly is crucial for timely treatment. miscommunication or misunderstanding among hypertensive patients, who are at the highest risk for stroke, increases stroke risk and complications. educating the public about stroke symptoms and responses is essential for prevention. therefore, a valid and reliable tool to assess hypertensive patients' stroke knowledge is important for improving long-term outcomes. this research aims to adapt the stroke knowledge test into turkish and evaluate its validity and reliability in hypertensive patients.

cerebrovascular diseases are the group of diseases that cause the most disability and loss of work, affect the quality of life the most and are the third leading cause of death in the world, and also have a significant place in hospital admissions and expenses. this rate increases with the aging population and comorbidities. the recognition of stroke symptoms by the society is the most important factor in patients reaching treatment opportunities without wasting time. it is known that failure to provide accurate information to hypertensive patients, who are the highest risk group for stroke, or the patient's failure to understand stroke is associated with a higher risk of stroke and complications. these findings indicate that it is important to provide information to the public about how they behave when they encounter symptoms related to stroke and related conditions. measuring stroke knowledge and risk factors in hypertensive and potential stroke patients can serve as a healthcare provider who informs the society to adopt stroke prevention behaviors. therefore, a valid and reliable assessment tool is of great importance in determining whether hypertensive patients have sufficient knowledge about stroke and improving the long-term clinical outcomes of stroke. this research aims to perform the cross-cultural adaptation of the stroke knowledge test into turkish and to examine the validity and reliability of the assessment tool in hypertensive patients.

Eligibility criteria:
inclusion criteria: * native turkish and literate * diagnosed with hypertension / history of ischemic or hemorrhagic stroke and * patients who signed the voluntary consent form will be included. exclusion criteria: * participants who are illiterate and * participants who have mental problems that may prevent them from answering the test will not be included in the study.

Keywords: stroke knowledge test stroke education validity reliability
effects of music intervention combined with progressive muscle relaxation in cancer patients

Conditions: Cancer

Summary: study design a 2-arm, assessor-blinded randomised controlled trial will be conducted. the design will follow the standard protocol items recommendations for interventional trials (spirit)

aim: to assess the effect of mcp on anxiety, depression and qol of bgc patients receiving chemotherapy. objectives * to assess the effect of mcp on the anxiety of bgc patients receiving chemotherapy. * to assess the effect of mcp on depression of bgc patients receiving chemotherapy. * to assess the effect of mcp on qol and patients' satisfaction of bgc patients receiving chemotherapy. * to determine whether stress level, coping and coping styles mediate the intervention effect on anxiety, depression and qol. hypothesis * the participants receiving mcp will have a significantly lower level of anxiety compared to the control group. * the participants receiving mcp will have a significantly lower level of depression compared to the control group. * the participants receiving mcp will have significantly higher qol scores and levels of satisfaction with care service compared to the control group. * stress level, coping will mediate the intervention on target outcomes.

Eligibility criteria:
inclusion criteria: * women with breast or gynaecological cancer are 18 years of age or older, and are independent legally to sign the consent form. * living with family and having an adult family member agree to participate in the meeting part of the program. * had been informed the cancer diagnosis * have karnofsky score (mor et al., 1984) ≥ 80 ( to be able to self-practice mcp) * can communicate, read and write in vietnamese * have a device such as a smartphone, mp3 to keep the audio file (to self-practice mcp at home) * consent to join the study exclusion criteria: * the patients cannot understand the study procedures * have mental health illness, deafness, blindness * have not been aware of their cancer or the purpose of chemotherapy * be participating in other studies related to psychological issues * be receiving anxiety or depression treatment. * be participating in relaxation therapy such as yoga, meditation, mindfulness, pmr... * have a potential treatment (eg. surgery) or personal plans that will prevent them from practising daily during the 6 weeks of the intervention.

Keywords: music intervention progressive muscle relaxation anxiety depression quality of life chemotherapy beast cancer gynaecology cancer
mfangano island healthy networks impact study

Conditions: HIV

Summary: this pilot study is a non-randomized controlled cohort study evaluating the impact of social network-based hiv education on antiretroviral therapy (art) adherence, clinical outcomes, food security, social support, hiv knowledge, and risk behaviors among people living with hiv/aids, as well as members of their associated social support networks. the intervention, known as the mfangano health net microclinic pilot program, consists of a 6-month education program on hiv biology, interpersonal communication and community mobilization for both hiv positive individuals and their self-selected social network members selected irrespective of hiv status. investigators hypothesize that participation in the microclinic program will improve art adherence, cluster of differentiation 4 (cd4) count, social support, hiv knowledge and food insecurity and will reduce hiv-related stigma, as compared to participants in control communities.


Eligibility criteria:
inclusion criteria: * hiv positive patient on art at sena health center or member of patient's social network * resident of mfangano island * 18 years of age or older * conversant in dholuo or english languages exclusion criteria: * none

Keywords: hiv stigma social support social network kenya
increasing vitamin intake and physical activity

Conditions: Heart Diseases; Diabetes Mellitus, Type 2; Behavior; Motivation

Summary: to help employees to adopt and maintain a healthy lifestyle, it is imperative to increase their self-management competencies. aim of this research project is to evaluate an evidence- and theory-based computerized expert system in comparison to waiting control group. employees will be treated psychologically and followed up over 18 months. the computerized expert system is expected to help employees significantly changing their lifestyle. the intervention is hypothesized to improve self-management competencies over and above the regular check-up at their medical appointment (i.e., waiting control group).

in a change setting (employees having a regular medical appointment), two interventions (one for nutrition change and one for activity change) will follow and assessments over a time period of 12 to 20 weeks will be conducted afterwards. study participants in the intervention groups receive an interactive, computerized expert system (intervention group, ig). individuals in the waiting control group (wcg) get nothing. employees (n = 1000) will be recruited at their regular medical appointment. study participants will be followed up over three measurement points: one to nine weeks after t1, t2 will take place. five to 13 weeks after t1 the t3 measurement will be conducted. the hypotheses are: in comparison to the wcg the employees in the ig are expected to have a higher motivation, to adopt a healthy lifestyle, to perform more health behavior and to be less likely to relapse into previous unhealthy routines. also, ig employees will be healthier as well as they will report more quality of life, more work satisfaction and more occupational efficiency . in comparison to wcg, the ig is also hypothesized to be more effective than the wcg regarding social-cognitive predictors of behavior. moreover, the interventions are supposed to be more effective for individuals with more risk factors (obese ect.). after successful evaluation and some adoptions the intervention will be implemented as a self-help program in all eligible employees in the intranet.

Eligibility criteria:
inclusion criteria: * to be capable of exercising on their own at a minimum level and/or to consume fruits and vegetables * able to fill out a questionnaire (no illiteracy) * adequate german language ability exclusion criteria: * no internet access * no computer with keyboard

Keywords: randomized controlled trial evidence- and theory-based behavioral intervention expert system stages of change motivational interviewing tailoring self care expert systems
safety and efficacy trial of testosterone undecanoate

Conditions: Male Hypogonadism

Summary: the purpose of the study is to determine if oral testosterone undecanoate is effective and safe in the treatment of low testosterone in men.


Eligibility criteria:
inclusion criteria: * serum testosterone of less than or equal to 300 ng/dl (the mean of two samples collected 1 hour apart in the morning between 6:00 and 10:00 am) exclusion criteria: * significant intercurrent disease of any type, in particular liver, kidney, uncontrolled or poorly controlled heart disease including hypertension, chf or cad, or psychiatric illness including depression. * recent history of stroke, including transient ischemic attack (tia) or acute coronary event * untreated, severe obstructive sleep apnea * hematocrit \ 48% * serum transaminases \>2 times upper limit of normal, serum bilirubin \>2.0 mg/dl, and serum creatinine \>2.0 mg/dl * bmi \> or equal to 38 * stable doses of lipid-lowering medication for less than three months * stable doses of oral medication for diabetes for less than two months * abnormal prostate digital rectal examination \[palpable nodule(s)\], elevated psa (serum psa \>3.9 ng/ml), ipss score \> or equal to 19 points, and /or history of prostate cancer. * history of breast cancer * use of dietary supplement saw palmetto or phytoestrogens and use of any dietary supplements that may increase serum t, such as androstenedione or dhea with the previous 4 weeks * know malabsorption syndrome and/or current treatment iwht oral lipase inhibitors * known history of abuse of alcohol or any drug substance with the previous 2 years * current use of antiandrogens, estrogens, oral cyp3a4 inducers or inhibitors, or long-acting opioid analgesics * receipt of any drug as part of a research study within 30 days of initial dose administration in this study * blood donation within the 12 week period before initial dose administration in this study

Keywords: testosterone male hypogonadism low testosterone
effectiveness of direct-to-patient outreach on colorectal cancer screening within a low income and diverse population

Conditions: Malignant Neoplasm of Large Intestine

Summary: the purpose of this study is to determine if the direct mailing of fecal occult blood testing (fobt) kits to patients who are due for colorectal cancer screening is an effective way to improve colorectal cancer screening rates within a low income and racially/ethnically diverse population.

patients ages 50 to 80 who are identified through the electronic health record as not being up to date on colorectal cancer screening are eligible for the study and will be randomly assigned to the intervention or usual care group. individuals in the intervention group will be mailed a letter informing them that they are due for colorectal cancer screening, educational material regarding colorectal cancer screening, a fecal occult blood testing (fobt) kit, directions on how to use and return the fobt kit. the proportion of patients assigned to the intervention versus usual care groups who complete a guideline recommended form of colorectal cancer screening within 4 months of the initiation of outreach will be compared.

Eligibility criteria:
inclusion criteria: ages 50 to 80 as of 12/31/2009 at least 2 visits to the community health center between 7/1/2008 and 12/31/2009 exclusion criteria: documented fecal occult blood testing (fobt) within 1 year (between 1/1/2009 and 12/31/2009) documented sigmoidoscopy within 5 years (between 1/1/2005 and 12/31/2009) documented colonoscopy within 10 years (between 1/1/2000 and 12/31/2009)

Keywords: colorectal cancer screening fecal occult blood testing (fobt) vulnerable populations community health center
efficacy, safety and pk of once or twice daily bilastine (10 or 20 mg) compared with placebo in the symptomatic treatment of sar

Conditions: Seasonal Allergic Rhinitis; Hay Fever; Allergic Conjunctivitis; Hypersensitivity

Summary: evaluate the relative efficacy of four dosing regimens of bilastine tablets (given either once or twice per day) versus placebo in patients with seasonal allergic rhinitis (sar) in the mountain cedar season in south texas and oklahoma based on the mean change from baseline in reflective total nasal symptom scores (tnss) assessed over 14 days of treatment.


Eligibility criteria:
inclusion criteria: * clinical history of seasonal allergic rhinoconjunctivitis with seasonal onset and offset of nasal allergy symptoms * documentation of a positive skin test within one year of screening to mountain cedar allergen exclusion criteria: * significant medical condition * significant nasal abnormality * significant cardiac condition * recent infection * use of other allergy medication during the study

Keywords: allergic rhinitis mountain cedar pollen pollen allergy rhinoconjunctivitis
effect of anesthetics on cd39 and cd73 after open-heart surgery

Conditions: Valvular Heart Disease; Aortic Disease

Summary: cd39 and cd73 was known protein expressed on surface of th1 and th17 cell and modulate immune related reaction. cardiopulmonary bypass (cpb) can induce inflammatory reaction during cardiac surgery, and induce immunosuppression. propofol and volatile anesthetics were related to immune reaction. however, the effect of propofol and sevoflurane on the change of cd39 and cd73 after cpb was not evaluated in previous studies. the authors hypothesized that the expression of cd39 and cd73 would differ between propofol- and volatile anaesthetic-based anaesthesia in patients undergoing cpb. therefore, the present study determined the effect of propofol and sevoflurane on cd39 and cd73 during and after cpb.

after obtaining permission of the institutional review board of konkuk university medical center, seoul, south korea , patients scheduled to undergo elective cardiac surgery under cardiopulmonary bypass (cpb) after signed written informed consent agreements and prospectively participate in the present study. all patients got a cardiac surgery under moderate hypothermic cardiopulmonary bypass (cpb) by one cardiac surgeon. also, 6ml of blood and sample was obtained for total 5 times in consecutive order. 1. before operation (pre-cpb1) 2. 15 minute after successful cpb weaning (post-cpb1) 3. 3 hrs after cpb weaning (post-cpb2) 4. 24 hrs after cpb weaning (post-cpb3) 5. 48 hrs after cpb weaning (post-cpb4) the following intraoperative exclusion criteria are applied: 1. emergency operation that could not obtain pre-cpb1 sample 2. patients who have infectious factor before operation 3. patients who have immunosuppressive agent for underlying disease before operation 4. patients who have history of cancer previously 5. patients who are younger than 19 years old using blood sample, authors examined as follows 1. flow cytometry for th 17 and th 1 cell. 2. immunocytochemistry for cd39, cd73. 3. assay for il 1,6,10,17,ifn-γ, and tnf-α 4. patient vital sign during operation 5. other laboratory tests statistical analyses are conducted using spss 20.0 (spss inc., chicago, il, usa). cd39 and cd73 are analysed used a repeated measures analysis of variance and their pairwise multiple comparisons are performed via the tukey method. the comparisons of the other continuous variables are performed by paired t or wilcoxon signed rank tests. data are expressed as mean ± sd (95% confidence interval. ci) or median (25%-75%), and number of the patients. a p value less than 0.05 is considered statistically significant.

Eligibility criteria:
inclusion criteria: 1. patients scheduled to undergo elective cardiac surgery 2. signed written informed consent agreements exclusion criteria: 1. emergency operation that could not obtain pre-cpb1 sample 2. patients who have infectious factor before operation 3. patients who have immunosuppressive agent for underlying disease before operation 4. patients who have history of cancer previously 5. patients who are younger than 19 years old
a study to assess the efficacy of hh-120 nasal spray for prevention of sars-cov-2 infection in adult close contacts of individuals infected with sars-cov-2

Conditions: SARS-CoV-2 Infection

Summary: an investigator-initiated, randomized, single-blind, placebo-controlled trial to evaluate the efficacy of sars-cov-2 post exposure prophylaxis and safety of hh-120 nasal spray


Eligibility criteria:
inclusion criteria: * participants aged 18 to 65 years. * participants who have close contact with a sars-cov-2 infected individual (index case) are required to be randomized within 72 hours upon close contact. * willing and able to provide written informed consent, or with a legal representative who can provide informed consent. exclusion criteria: * have a history of severe allergy or hyper-sensitivity to inhaled allergen. * pregnant or breastfeeding women. * have participated, within the last 180 days prior to the screening, in a clinical study involving an investigational intervention of sars-cov-2 neutralizing antibody. * have other conditions not suitable for the study per investigator's discretion.
investigation of the relationship between sensory processing and kinesychophobia in fibromyalgia patients

Conditions: Fybromyalgia

Summary: fibromyalgia; is a chronic and rheumatic condition characterized by diffuse pain. in patients with fibromyalgia syndrome, there is an increase in psychiatric symptoms, especially depression, anxiety, and somatoform disorders. kinesophobia is defined as anxiety against pain and pain caused by painful injury and re-injury. the aim of this study was to investigate the relationship between kinesophobia and sensory processing in patients with fibromyalgia.

fibromyalgia; is a chronic and rheumatic condition characterized by diffuse pain. in patients with fibromyalgia syndrome, there is an increase in psychiatric symptoms, especially depression, anxiety, and somatoform disorders. kinesophobia is defined as anxiety against pain and pain caused by painful injury and re-injury. the aim of this study was to investigate the relationship between kinesophobia and sensory processing in patients with fibromyalgia.

Eligibility criteria:
inclusion criteria: * 18-65 years old * diagnosed by fibromyalgia * no other known physical, neurological and psychological illness * literate * volunteers to participate in the study exclusion criteria: * not compliant with inclusion criteria

Keywords: kinezyhophobia sensory processing fybromyalgia