Kornimate/medical-research-clean huggingface dataset:
measuring adherence in subjects with acne vulgaris in a clinic population subtitle: topical benzoyl peroxide for acne

Conditions: Acne Vulgaris

Summary: the purpose of this research study is to see how often benzoyl peroxide is applied for acne. use of medication was monitored electronically.

we give subjects topical benzoyl peroxide, a standard first line acne treatment, in a container that records when the container is opened and closed. subjects will simply be asked to "return in six weeks to see how well benzoyl peroxide works for them." subjects initially will not be told that they are participating in a formal study. when they return with their medication, we will seek their informed consent to participate in the study. verbal consent will be obtained at the beginning of the study. there will be no written consent obtained until the end of the study. by doing this, subjects will not be aware that adherence is being measured. subjects will not be aware that they are participating in a study. only if they consent would we then collect the medication container and monitor and retrieve the adherence data. if they do not consent, we will not have collected any research data on them except baseline acne severity measures which may have been collected anyway as part of their clinic treatment.

Eligibility criteria:
inclusion criteria: * any male or female 13 to 18 years of age with a diagnosis of mild to moderate acne vulgaris by a dermatologist will be eligible for participation. * verbal consent of participation must be given by parent or guardian and child. exclusion criteria: * age less than 13 or greater than 18 years of age. * known allergy or sensitivity to topical benzoyl peroxide gel in the subject. * inability to complete all study-related visits. * introduction of any other prescription medication, topical or systemic, for acne vulgaris while participating in the study. * subjects should not be using topical retinoids or benzoyl peroxide products, including proactive® or topical prescription medications for the treatment of acne vulgaris for at least 2 weeks prior to beginning the study. oral medications for the treatment of acne should not have been used at least 4 weeks prior to beginning the study. * women that are actively trying to become pregnant or wish to become pregnant during the time frame the study is to take place will be excluded.
randomized study of organ care system cardiac for preservation of donated hearts for eventual transplantation

Conditions: Heart Failure

Summary: the purpose of the study is to compare survival of both patients and newly transplanted hearts following heart transplantation among patients who were transplanted with donated hearts preserved on ice and those who were transplanted with donated hearts using the organ care system (ocs). the organ care system preserves the hearts in a warm blood perfused beating state. the study also compares the number of rejection episodes, heart related adverse events, icu time, and ventilation time between the two groups. the study is considered a success if survival in the ocs group was not inferior to the ice group.


Eligibility criteria:
inclusion criteria: recipient day of transplant * registered male or female primary heart transplant candidate * ≥18 years old * signed, written informed consent document and authorization to use and disclose protected health information donor hearts * \<60 years old * mean systolic blood pressure \>60 mmhg at the time of final heart assessment * satisfactory echocardiography assessment defined as: * ejection fraction \>40% * absence of severe segmental wall motion abnormalities * absence of left ventricular hypertrophy (inter ventricular septum and posterior wall thickness \<1.3 cm) * absence of valve abnormalities (trace to mild valvular regurgitation is acceptable) exclusion criteria: recipient day of transplant * \>4 previous sternotomies * chronic renal failure as defined by chronic serum creatinine \>3.0 mg/dl for more than 2 weeks and/or requiring hemodialysis (except for hemodialysis or hemofiltration for fluid overload) * ventilator dependence at the time of transplant * use of a ventricular assist device for \> 30 days and the presence of any of the following: sepsis, intracranial hemorrhage or heparin induced thrombocytopenia * panel reactive antibodies \> 40% with a positive prospective cross match and/or virtual cross match * use of an investigational drug or device, other than ocs, during the study. * simultaneous transplant of non-heart allograft, except for concurrent kidney transplant donor hearts * abnormal coronary angiogram defined as \>50% stenosis, requiring coronary bypass * donor-to-recipient body weight ratio of \<0.6 * inotrope support at time of final heart assessment including, but not limited to: * dopamine \>10 ug/kg/min * dobutamine \> 10 ug/kg/min * milrinone \>0.3 ug/kg/min * epinephrine \> 0.03 ug/kg/min * norepinephrine \> 0.03 ug/kg/min * any bolus dose of the above prior to explants that would result in exceeding the above stated criteria * presence of any exclusion criterion based on the standard practice of the investigational site

Keywords: heart failure transplant warm perfusion organ care resting mode
a study of abt-751 in patients with renal cell cancer

Conditions: Renal Cell Cancer

Summary: the purpose of the study is to determine if abt-751 will decrease tumors, and determine how long the tumor shrinkage can be maintained in patients with renal cell cancer. patients will receive abt-751 by mouth daily for 21 days. patients will be off drug for 7 days before starting the next cycle of drug.


Eligibility criteria:
inclusion criteria * renal cell carcinoma. * recurrent tumor. * at least 6 weeks post-nephrectomy. * able to tolerate normal activities of daily living. * adequate bone marrow, kidney, and liver function. exclusion criteria * pregnant or breast feeding. * anti-tumor therapy within 4 weeks of the start of abt-751 administration. * cns metastasis.
perioperative lignocaine and sleep disturbance

Conditions: Sleep Disturbance

Summary: the aim of this clinical trial is to study the effect of an intravenous infusion of lidocaïne in a multimodal analgesic protocol on the architecture sleep during the first postoperative night.

to study the effect of lidocaïne, we plan to include 40 patients, randomized in 2 groups, undergoing open prostate surgery in this randomized placebo-controlled trial. before anesthesia induction, these patients receive an intravenous lidocaine infusion (bolus 1,5 mg.kg-1 followed by a continuous infusion of 2mg.kg-1.h during 24 hours) or an equal volume of placebo. then the anesthesia is induced with propofol, sufentanil et rocuronium. the postoperative analgesia is provided by paracetamol, tramadol and patient-controlled analgesia (pca) with morphine or oral oxycodone. a polysomnography is registred on the preoperative night and on the first postoperative night.

Eligibility criteria:
inclusion criteria: * radical prostatectomy exclusion criteria: * bmi \> 30 * neurologic/psychiatric diseases or therapeutics, seizyres * cardiac disease, second or third degree atrioventricular block * obstructive sleep apnea syndrome * history of liver or renal insufficiency * and any contraindication to the anesthetic protocol of the study.
efficacy of psychological therapy in chronic pain and fibromyalgia

Conditions: Fibromyalgia; Chronic Pain

Summary: today, one of the most important challenges of the health system is the attitude towards chronic disorders. that implies changing from a health structure established for the treatment of acute diseases to a continued care system. in this sense, the approach of chronic pain, of non-oncological origin, supposes an important care challenge, to which this project wishes to respond. chronic pain affects one of every europeans (19%), and has a prevalence of 11% in spain, being one of the most important causes of medical consultation and is associated with high personal, social and economic costs. for example, in 2017 it was calculated that it has an economic impact of between 1.7 and 2.1% of spain's gdp. referred to the psychological consequences of the disease, it has been found that 42% of people who have chronic pain suffer insomnia, a 40% anxiety, and 24% depressive symptoms. hence the importance of implementing evidence-based psychological treatments along with their treatment as usual the main objective is comparing the efficacy of mindfulness-based pain management (mbpm), together with the usual medical treatment, in patients diagnosed with chronic pain, with and without comorbid fibromyalgia. specific objectives are: 1. to study the sociodemographic and clinical profile of patients with chronic pain, with and without fibromyalgia. 2. define the characteristics of patients who are in the different stages of the disease: stage 1 (less than two years since diagnosis); stage 2 (between 2 and 4 years); stage 3 (between 5 and 8 years), and stage 4 (more than 8 years). 3. check the effectiveness of psychological therapies mbpm depending on the presence of fibromyalgia. 4. check the effectiveness of the psychological treatment in function of the stage of the disease. method: a quasi-experimental design of two groups will be used. patients will be assigned to experimental group: 50 subjects will receive mbpm and control group 40 subjects, 3-months wait list, after which time they will also receive mbpm. all the participants will be assessed in the baseline; at the end of the treatment; and in the 1, 3, 6 and 12 months follow-ups. group 2 (waiting list) will be assessed in the baseline, and re-assessed before starting the treatment; at the end of the psychological therapy; and in the 1, 3, 6 and 12 months follow-ups.

the objetive of this research are the study of efficacy in chronic pain and fybromyalgia of mindfulness therapy.

Eligibility criteria:
inclusion criteria: * be able to complete the assessment protocol * suffer from chronic non-oncological pain, lasting longer than 6 months * not being receiving psychological treatment * sign the informed consent exclusion criteria: * present a cognitive impairment, such as a dementia * present a diagnosis of a psychotic disease, bipolar disease or additive disease

Keywords: fibromyalgia chronic pain psychological treatment effectiveness mbpm
reliability and validity evaluation of the bepow device

Conditions: Position Sense Disorders

Summary: the aim of this clinical investigation is to develop a reliable and valid device to instantly measure the subject's sitting posture in a wheelchair, without using the mcpaa scale.

each subject will be invited to a single experimental session lasting approximately one hour, during which all assessments will be performed. during the visit, the patient will complete an autonomy questionnaire and assess wheelchair fatigue. a spirometry test will be performed. the measurements will then be recorded by the bepow software and the occupational therapist.

Eligibility criteria:
inclusion criteria: * over 18 years of age, * having freely consented to participate in the study (or their legal representative in the case of guardianship, in agreement with the patient), * in the case of a guardianship, the legal representative having read the information document intended for the legal guardian of an adult under legal protection (under guardianship) and given his/her free and informed consent for the person for whom he/she is responsible to participate in the study (in agreement with the patient). * temporarily or permanently wheelchair-bound, * affiliated with a social security scheme or beneficiary of such a scheme. exclusion criteria: * has comprehension problems that prevent him/her from giving free and informed consent and from completing the investigation (following instructions, answering questionnaires), * suffering from a pathology (huntington's disease, sydenham's chorea) preventing stable sitting posture during participation in the investigation, * have undergone an amputation that prevents the bepow device from taking measurements, * having undergone a tracheotomy preventing spirometry. * pregnant, parturient or breast-feeding women, * person deprived of liberty by a judicial decision (except guardianship or curatorship) or or administrative decision, a person under psychiatric care or admitted to a or social establishment for purposes other than research, * minors, * person in an emergency situation unable to give prior consent.
targeted physical function exercises on frailty and falls management in pre-frail community-dwelling older adults

Conditions: Frailty Syndrome; Pre-frail Older Adults

Summary: the investigators will conduct a randomized controlled trial to assess the impact of targeted physical function exercises on frailty and falls in community-dwelling adults over 65 years of age. participants will be randomized to an intervention and a control group to undergo an 18-month assessment. the hypothesis of this study is to investigate the impact of targeted physical function exercises on managing frailty status and concerns about falling among pre-frail older adults. by implementing individualized intervention programs tailored to improve strength, balance, and mobility, the investigators aim to enhance physical function and reduce the risk of frailty-related adverse health outcomes. the investigators seek to empower pre-frail older adults to proactively manage their health, maintain independence, and improve their quality of life as they age.


Eligibility criteria:
inclusion criteria: * participants aged 65 and over * classified as pre-frail according to share-frailty instrument * independent of movement and activity * able to perform mini-mental status examination (mmse) score ≥24 exclusion criteria: * severe contraindications for physical exercise * central nervous system impairments * inability to speak and understand greek properly * a cognitive state that prevents understanding the researcher's instructions

Keywords: frailty concerns about falling physical function exercises
initial volume status in patients with acute brain injury is associated with neurological prognosis

Conditions: Acute Brain Injury; Paroxysmal Sympathetic Hyperactivity; Volume Status; Right Heart Function; Right Cardiogenic Pulmonary Edema; Glasgow Outcome Scale Extended

Summary: in this study, we investigated the clinical variability in paroxysmal sympathetic hyperactivity in patients with acute brain injury and examined the prognostic value of the paroxysmal sympathetic hyperactivity assessment measure (psh-am) in relation to doppler ultrasound assessment of volume status, right heart function, and pulmonary edema. thirty patients with abi were prospectively enrolled. a correlation analysis between the psh-am score and related clinical indicators was performed using pearson's or spearman's correlation coefficient. receiver operating characteristic curves were used to assess the prediction of the 6-month glasgow outcome scale extended score for neurorehabilitation prognosis.


Eligibility criteria:
inclusion criteria: * only adult patients (\>18 years of age) were included. the other inclusion criteria were 1) definite cerebrovascular accident or craniocerebral injury (a clear change in consciousness or suggestive imaging); 2) the ability to undergo ultrasound to obtain information on volume status and cardiac and pulmonary monitoring; and 3) fulfilment of the measurement conditions. exclusion criteria: * the exclusion criteria were 1) a history of cardiovascular disease, such as coronary artery disease, heart failure, or atrial fibrillation; 2) presence of severe valvular disease or an ef of \<30%; 3) chronic lung disease; 4) chronic liver failure or renal insufficiency; 5) comorbid malignant neoplasm or acute/chronic infectious disease prior to craniocerebral injury; 6) pregnancy or breastfeeding; 7) history of psychiatric disorders; 8) history of drug abuse or alcohol misuse; 9) history of β-blocker use; 10) comorbid spinal cord injury; 11) death or discharge from hospital within 5 days of hospitalization.
analysis and optimization of predictive and therapeutic models in uterine neoplasms

Conditions: Uterine Neoplasms

Summary: evaluation of clinical, therapeutic and prognostic relevance of new experimental results as well as optimization of therapeutic models and development of a new algorithm for therapeutic plan and therapy in patients with uterine neoplasm


Eligibility criteria:
inclusion criteria: * confirmed uterine malignancy ( cervical cancer, endometrial cancer, sarcoma) * if operable: surgical primary therapy: laparoscopic/robot-assisted or open radical gyneco-oncological surgery * written consent * willingness and ability to participate in all study-specific procedures * age ≥ 18 years exclusion criteria: * severe and acute general disease in the last 4 weeks * acute or chronic psychiatric disorders * other factors questioning study participation (e.g. acute psychosocial stress, insufficient understanding of nature and consequences of the study, inadequate skills of the german language)
comparing press and filiform needle acupuncture effectiveness for improving insomnia in covid-19 healthcare workers

Conditions: Insomnia

Summary: the purpose of this study is to compare the effectiveness of manual acupuncture between 2 types of needles in subsiding insomnia symptoms of healthcare workers who were responsible for treating covid-19 patients in cipto mangunkusumo hospital.

the purpose of this study is to compare the effectiveness of manual acupuncture between press needles and filiform needles for subsiding insomnia symptoms based on changes in the pittsburgh sleep quality index (psqi) questionnaire score and examination of melatonin in blood. if the press needles proven to be superior, this method would also be more beneficial during this pandemic as this can shorten the time and/or frequency of the therapy sessions, hence reducing interaction and risk of covid-19 transmission.

Eligibility criteria:
inclusion criteria: * health care workers treating covid-19 patients in cipto mangunkusumo hospital. * has symptoms of insomnia for at least 2 weeks (screened using the phq-9 instrument modified to question number 3a with an answer score of at least 1) * age 20 - 50 years. * has negative covid-19 rapid test or pcr swab result in the 7 days prior to the study. * willing to participate in research by signing an informed consent. * willing to follow the research process to completion. exclusion criteria: * if you answered yes to phq-9 number 3a never or 3b with a yes * insomnia is caused by moderate pain (with numeric rating scale \> 4) * insomnia patients with medical therapy such as benzodiazepines, non-benzodiazepines, melatonin drugs and antidepressants * has severe social and occupational dysfunction (with the global assessment of functioning \< 50). * has a history of contraindications to acupuncture such as medical emergencies, pregnancy, thrombocytopenia with a platelet count below 50,000 per microliter of blood, history of blood clotting disorders / taking blood thinners, puncturing over malignant tumors, or infection or scarring in the acupuncture area. * the patient is febrile with a temperature more than 38 celsius * have had acupuncture in the last 7 days prior to study. * no limbs * cognitive impairments or impaired consciousness

Keywords: acupuncture press needle insomnia healthcare worker
diagnostic performance of ultrasound elastography for detection of thyroid cancer

Conditions: Elastography; Thyroid Nodule

Summary: for patients with thyroid gland nodule, fine-needle aspiration biopsy has been proved to be an efficient tool for thyroid cancer diagnosis. however, it is somewhat an invasive procedure and is subject to sampling and analysis uncertainties. thus, improved, more reliable criteria for determining which nodule should be be aspirated are needed. ultrasound elastography has been shown to be useful in the differential diagnosis of breast and prostate cancers. ultrasound elastography also may discriminate malignant from benign nodule.

to prospectively evaluate the elastographic appearance of thyroid cancer and explore the potential sensitivity and specificity of elastography for differentiating benign and malignant tumors, with histopathologic analysis as the reference standard.

Eligibility criteria:
inclusion criteria: - the patients with thyroid nodule who are supposed to take fine needle aspiration biopsy exclusion criteria: - the patients who do not want to participate in the study

Keywords: elastography thyroid nodule
alternative support for rural and isolated women in an hmo

Conditions: Stress Disorders, Post-traumatic; Depression; Breast Cancer

Summary: evaluate the effects of a workbook/journal for helping isolated women to cope with breast cancer.


Eligibility criteria:
inclusion criteria: * 1) is a woman; and 2) has been diagnosed with primary breast cancer exclusion criteria: * 1) is under 18; or 2) can not speak and read in english
a randomized controlled trial of a water protocol for clients with thin liquid dysphagia

Conditions: Thin Liquid Dysphagia

Summary: the purpose of the gf strong water protocol is to allow clients who have thin liquid dysphagia to drink water under certain specified conditions according to the rules of the water protocol. water protocols have been shown to improve client satisfaction, and hydration. we wish to assess this in a randomized, controlled fashion, and this is a pilot project to determine feasibility.

gf strong water protocol will be used with the study subjects. control subjects will not receive water protocol. pre and post measures will include swal-qol, client satisfaction, water and thickened fluid intake, and monitoring for adverse events.

Eligibility criteria:
inclusion criteria: potential participants in this study will include all clients aged 19 years and older who are admitted to gf strong acquired brain injury (abi) and neruomusculoskeletal (nms) and adolescent and young adult (aya) programs and who have thin liquid dysphagia resulting from a neurological diagnosis. the thin liquid dysphagia will be confirmed by a modified barium swallow conducted by a certified speech-language pathologist. potential participants must be proficient in english in order to complete the questionnaires and capable of understanding the consent form. exclusion criteria: clients who present with the following will be excluded: active pneumonia, acute or unstable medical condition, surgery where coughing might rip stitches or cause pain or discomfort, oral dental bacteria or infection that cannot be controlled, poor oral hygiene that cannot be improved with routine care, excessive or uncomfortable coughing during or after intake, severe or uncontrolled gerd, immunosuppressed, or decline participation.

Keywords: water oral care oral hygiene dysphagia thin liquid dysphagia thickened liquids