Kornimate/medical-research-clean huggingface dataset:
effects of particulate matter on the pulmonary function and acute exacerbation of copd and asthma

Conditions: Pulmonary Function

Summary: particulate matter(pm) exposure has been shown to increase the morbidity and mobility of a variety of respiratory diseases, including copd and asthma. this study focus on the effects of pm on the pulmonary function and acute exacerbation of copd and asthma patients in china, where pm exposure is much heavier than the united states and european countries.

particulate matter(pm) exposure has been shown to increase the morbidity and mobility of a variety of respiratory diseases, including copd and asthma. this study focus on the effects of pm on the pulmonary function and acute exacerbation of copd and asthma patients in china, where pm exposure is much heavier than the united states and european countries. this study is an observational study which lasts 3 years. primary outcome measures:change in spirometry (fev1) of copd, asthma patients and healthy volunteers in response to different exposure doses of pm.

Eligibility criteria:
inclusion criteria: 1. copd patients: clinical manifestation of copd; post bronchodilator fev1/fvc\<0.70. 2. asthma patients: clinical manifestation of asthma; recurrent dyspnea; with or without wheezing; relief spontaneously or after using bronchodilators; fev1/fvc\<0.70,with positive bronchial reversible test. 3. asthma combined with copd (acos) patients: patients with acos are included in asthma group. 4. healthy volunteers: no smoking history, or have quit smoking at least 5 years. chest x-ray show no abnormality. 5. information consent form should be signed before entering the study. exclusion criteria: 1. the latest severe acute attack occurred within 4 weeks: 1. severe acute attack: status asthmaticus or acute exacerbation of copd leading to consultation, emergency treatment，hospitalization, or glucocorticoid treatment（oral/i.v). 2. controllable non-hospitalized acute attack without glucocorticoid treatment(oral/i.v). copd attack lasting less than 48h or asthma attack lasting less than 24h are not excluded. 2. any history of acute/chronic respiratory diseases other than asthma and copd, including lung cancer and pulmonary infection. 3. plasma alt or ast greater than 2 times of the upper normal limit; plasma creatinine greater than 1.5 times of the upper normal limit. 4. left heart insufficiency, or malignant arrhythmia. 5. hiv positive. 6. acute cerebrovascular events within 3 months, including apoplexy, transient cerebral ischemia and acute coronary syndrome. 7. uncured malignant tumors. 8. addicted to drug or alcohol, or any history of psychiatric disorders. 9. breastfeeding, pregnancy or planning to be pregnant. 10. estimated lifetime less than 2 years due to underlying diseases.

Keywords: pulmonary function particulate matter copd asthma
circulating tumor dna (ctdna) monitoring in the assessment and prediction of the efficacy of parp inhibitors (parpi)

Conditions: Metastatic Castration-resistant Prostate Cancer

Summary: to evaluate the application value of customized ctdna monitoring in efficacy assessment and prediction during parpi treatment

this clinical study is an open-label, single-center, observational study to evaluate the application value of customized ctdna monitoring in efficacy assessment and prediction during parpi treatment in mcrpc patients. a total of 30 participants with second-line treatment failure will be registered in this study. whole blood collection will be conducted during the treatment for ctdna detection, homologous recombination repair (hrr) genes testing, personalized panel customization and whole exome sequencing.

Eligibility criteria:
inclusion criteria: patients must meet all of the following criteria: 1. willing and able to provide informed consent. 2. adult males from 18 to 75 years age. 3. history of histologically or cytologically confirmed adenocarcinoma of the prostate with homologous recombination deficiency or ddr genes mutation (brca1/2, atm, bard1, brip1, cdk12, chek1, chek2, fancl, palb2, ppp2r2a, rad51b, rad51c, rad51d, rad54l) detected by high throughput sequencing 4. documented evidence of metastatic castration resistant prostate cancer (mcrpc) and proposed treatment of parp inhibitors. 5. evidence of measurable target lesion in imaging studies. 6. participants can provide adequate formalin fixed paraffin-embedded (ffpe) tumor tissue collected before any treatment: tumor cell content\>30% and necrotic cells\<10%. 7. ecog performance status 0-1 8. estimated survival≥12 weeks exclusion criteria: patients must not meet any of the following criteria: 1. do not meet the inclusion criteria. 2. under any other anti-tumor therapy like chemotherapy and/or immunotherapy. 3. receiving organ transplantation in the last 3 months. 4. participants with autoimmune diseases or history of hbv, hcv or hiv infection (acute or chronic). 5. participants with pneumonia. 6. severe concurrent illness or co-morbid disease that would make the subject unsuitable for enrolment 7. unwilling and unable to provide informed consent. 8. patients who are judged unsuitable for clinical trial participation by the investigators. elimination criteria: violation of the prescribed rule of medication that may influence the judgment of curative effect and safety.
left bundle branch pacing versus right ventricular pacing in patients with atrioventricular block

Conditions: AVB - Atrioventricular Block

Summary: although emerging evidence demonstrated that left bundle branch pacing (lbbp) is a promising alternative for patients with either a bradycardia or a heart failure pacing indication. however, a direct comparison of the safety, efficacy and lv systolic synchrony between lbbp and rvp regimens was rare. in this study, the investigators aim to conduct a comparison of the safety and effectiveness performance between these two pacing methods for patients with atrioventricular block (avb). the investigators focused on avb patients undergoing permanent pacemaker implantations from the 1st of january 2018 to the 18th of november 2021 at west china hospital.

right ventricular pacing (rvp) is the standard treatment for patients with continuous ventricular pacing needs. however, clinical studies have shown that rvp can cause electrical and mechanical dyssynchrony of the left ventricle and increase the risks of cardiac insufficiency, atrial fibrillation (af) and death. although emerging evidence demonstrated that left bundle branch pacing (lbbp) is a promising alternative for patients with either a bradycardia or a heart failure pacing indication. however, a direct comparison of the safety, efficacy and lv systolic synchrony between lbbp and rvp regimens was rare. in this study, the investigators aim to conduct a comparison of the safety and effectiveness performance between these two pacing methods for patients with atrioventricular block (avb). the investigators focused on avb patients undergoing permanent pacemaker implantations from the 1st of january 2018 to the 18th of november 2021 at west china hospital.

Eligibility criteria:
inclusion criteria: * included consecutively high-grade avb patients undergoing permanent pacemaker implantations from the 1 s t of january 2018 to the 18 thof november 2021 at west china hospital exclusion criteria: * patients with pacemaker replacements were excluded.

Keywords: left bundle branch pacing right ventricular pacing mortality systolic dyssynchrony
trial to evaluate safety and immunogenicity of gsk biologicals' influenza vaccine gsk2584786a in healthy children

Conditions: Influenza; Influenza Vaccines

Summary: the purpose of this observer-blind study is to evaluate the safety and immunogenicity of glaxosmithkline biologicals' influenza vaccine gsk2584786a in healthy children 6 to 35 months of age.


Eligibility criteria:
inclusion criteria: all subjects must satisfy all the following criteria at study entry: * subjects who the investigator believes that parent(s)/legally acceptable representative(s) \[lar(s)\] can and will comply with the requirements of the protocol * children, male or female between, and including, 6 and 35 months of age at the time of the first vaccination. * written informed consent obtained from the parent(s)/lar(s) of the subject. * healthy subjects as established by medical history and clinical examination before entering into the study. * age appropriate scheduled childhood vaccinations completed to the best of parent(s)/lar(s) knowledge. * born after gestation period of 36 to 42 weeks inclusive exclusion criteria: the following criteria should be checked at the time of study entry. if any exclusion criterion applies, the subject must not be included in the study: * child in "care" * use of any investigational or non-registered product other than the study vaccine(s) within 30 days preceding the first dose of study vaccine, or planned use during the study period. * prior receipt of any influenza vaccination or planned administration during the study period. * planned administration of any vaccine 30 days prior and 30 days after any study vaccine administration. * chronic administration of immunosuppressants or other immune-modifying drugs within six months prior to the first vaccine dose. * any confirmed or suspected immunosuppressive or immunodeficient condition, based on medical history and physical examination. * a family history of congenital or hereditary immunodeficiency. * a family history of febrile seizures or/and epilepsy * any known or suspected allergy to any constituent of influenza or routine paediatric vaccines, a history of severe adverse reaction to any previous vaccination; or a history of anaphylactic-type reaction to any constituent of influenza vaccine. * history of any progressive neurological disorders or seizures. * acute or chronic, clinically-significant pulmonary, cardiovascular, hepatic or renal functional abnormality, as determined by medical history or physical examination. * acute disease and/or fever at the time of enrolment: * - fever is defined as temperature ≥ 37.5°c on oral, axillary or tympanic setting, or ≥38.0°c on rectal setting. * subjects with a minor illness without fever might be enrolled at the discretion of the investigator. * administration of immunoglobulins and/or any blood products within the 3 month preceding the first dose of study vaccine or planned administration during the study period. * any condition which, in the opinion of the investigator, render the subject unfit for participation in the study.

Keywords: immunogenicity safety influenza children vaccine
indocyanine green tracer using in laparoscopic gastrectomy with lymph node dissection

Conditions: Stomach Neoplasms; Indocyanine Green

Summary: the purpose of this study is to explore the clinical outcomes of indocyanine green tracer using in laparoscopic gastrectomy with lymph node dissection for gastric adenocarcinoma（ct1-4a, n-/+, m0）.

indocyanine green tracer is often applied in surgery for early gastric adenocarcinoma. its application in laparoscopic gastrectomy with lymph node dissection for gastric adenocarcinoma is at the stage of cases accumulation, method studying and clinical research. there is no prospective studies to identify the clinical outcomes of indocyanine green tracer using in laparoscopic gastrectomy with lymph node dissection for gastric adenocarcinoma. on the basis of more than 3000 cases of laparoscopic gastrectomy with lymph node dissection for gastric adenocarcinoma, we want to apply the indocyanine green tracer, a cheap, easy to operate and no radiation pollution way, to predict the positive lymph nodes in gastric adenocarcinoma, to guid the scope of laparoscopic lymph node dissection for gastric adenocarcinoma.

Eligibility criteria:
inclusion criteria: * age from 18 to 75 years * primary gastric adenocarcinoma (papillary, tubular, mucinous, signet ring cell, or poorly differentiated) confirmed pathologically by endoscopic biopsy * clinical stage tumor 1-4a (ct1-4a), n-/+, m0 at preoperative evaluation according to the american joint committee on cancer (ajcc) cancer staging manual seventh edition * no distant metastasis, no direct invasion of pancreas, spleen or other organs nearby in the preoperative examinations * performance status of 0 or 1 on eastern cooperative oncology group scale (ecog) * american society of anesthesiology score (asa) class i, ii, or iii * written informed consent exclusion criteria: * women during pregnancy or breast-feeding * severe mental disorder * history of previous upper abdominal surgery (except laparoscopic cholecystectomy) * history of previous gastrectomy, endoscopic mucosal resection or endoscopic submucosal dissection * enlarged or bulky regional lymph node diameter over 3cm by preoperative imaging * history of other malignant disease within past five years * history of previous neoadjuvant chemotherapy or radiotherapy * history of unstable angina or myocardial infarction within past six months * history of cerebrovascular accident within past six months * history of continuous systematic administration of corticosteroids within one month * requirement of simultaneous surgery for other disease * emergency surgery due to complication (bleeding, obstruction or perforation) caused by gastric cancer * fev1\<50% of predicted values * diffuse; widespread; plastica

Keywords: stomach neoplasms indocyanine green tracer laparoscopic gastrectomy lymph node dissection
investigating the functional characteristics of white matter fibers during wakefulness and sleep based on seeg

Conditions: Refractory Epilepsy; Sleep

Summary: this study aims to include electrophysiological and clinical data from patients aged 14-65 with drug-resistant epilepsy who underwent seeg electrode contacts traversing the brain's white matter. the collected data will be analyzed to investigate the functional characteristics of white matter fibers during wakefulness and sleep.

sleep is a crucial function, and its disruption can have multiple effects on health. the daily alternation between sleep and wakefulness is one of the most dominant features of our lives and is a manifestation of the intrinsic 24 h rhythmicity underlying almost every aspect of our physiology. the cerebral cortex makes up about 80% of the brain's volume and is responsible for many complex phereducednomena, including perception, thought, language, attention and memory. sleep is considered a global state that influences the coordinated activity of the entire brain. during sleep, studies have shown that the connectivity between neurons in the cerebral cortex weakens. white matter connects different brain regions, facilitating communication between various neural structures.our scientific hypothesis is that white matter connectivity should also reduced. stereoelectroencephalography (seeg) can directly record brain signals, providing a new method for tracking of connections between different brain areas, providing a new approach for understanding neuronal functional states and cortical excitability.studying the functional characteristics of white matter fibers during wakefulness and sleep.based on seeg and ccep, this study aims to investigate the functional characteristics of white matter fibers during wakefulness and sleep.

Eligibility criteria:
inclusion criteria: * drug-resistant focal epilepsy * justified seeg exploration in the context of presurgical assessment of epilepsy * subjects will be a part of the epilepsy-monitoring unit for long-term seeg recordings and analysis * written non-opposition to study participation exclusion criteria: * pregnant women (contraindication to seeg exploration) * subjects that experience surgical complications during the implant procedure will be excluded from the study
a prognosis and predicting genetic study of lung cancer

Conditions: Lung Cancer; Genetic Predisposition to Disease

Summary: lung cancer is a leading cause of cancer mortality among adults worldwide. the incidence rates of lung cancer among never smoking females in some parts of east asia are among the highest in the world. the adenocarcinoma of lung being the most frequently identified histological type is more weakly associated with smoking, and often occurs in females and never-smokers. although family history of lung cancer has been associated with histological subtypes, the inherited susceptibility factors that affect specific histology are unknown. genetic factors that determine individual predisposition to lung cancer have been identified via genome-wide association studies. these known common loci, however, explain only a small fraction of the familial risk of lung cancer. the hypothesis of this study is that there are genetic factors that confer inherited susceptibility among patients with primary non-small-cell lung cancer (nsclc).

to delineate the genetic etiology underlying nsclc, this study proposes to employ a family-based linkage analysis, together with rich data generated from ngs, to search for disease susceptibility locus for the patients with strong family history of primary nsclc. by using family pedigrees, linkage analysis will be able to find co-segregation of alleles through multiple generations at a genetic susceptibility locus and a known genetic marker, and then the highly penetrate gene loci may be detected by our study. these gene loci will be a good genetic predictor of nsclc which should be a great advantage in treatment, prevention and screening of nsclc in the future.

Eligibility criteria:
inclusion criteria: 1. the patient's family (within third-degree relatives) has at least one diagnosed of primary non-small cell lung cancer. 2. the patient was diagnosed of primary non-small cell lung cancer at the age \< 45 years old. exclusion criteria: 1. patients without the diagnosis of primary non-small cell lung cancer. 2. patients who are combined with other malignancy and ongoing chemotherapy / radiation therapy. 3. patients combined with coagulopathy.

Keywords: non small cell lung cancer genetic study
electromyography of the pectoral muscle in mastalgia patients

Conditions: Mastalgia

Summary: mastalgia is a common problem for women. the aim of this study is to investigate the role of neuromuscular pathologies of the thorax wall at mastalgia ethiopathogenesis.

mastalgia is a common health problem for women especially these days. studies demonstrated that 48% of the women with mastalgia have serious difficulties in their sexual life, 36% have physical activity difficulties, 13% have social activity difficulties and 6% have work or school activity difficulties. the etiology of the mastalgia is not clear. because of the women with mastalgia tested out lots of examinations for the etiology. also this problem has financial load because of the unknown etiology.

Eligibility criteria:
inclusion criteria: * subject has unilateral mastalgia exclusion criteria: * subject has pregnancy * subject has breast cancer * subject has a history of breast operation * subject has diabetes mellitus * subject has 1 cm or above cystic or solid lesions in the breasts.

Keywords: mastalgia electromyography pectoral
the effect of body posture on intraocular pressure in progressive glaucoma

Conditions: Glaucoma

Summary: glaucoma is a condition where the optic nerve (the nerve responsible for sight) shows progressive damage with characteristic loss of visual field. glaucoma is very commonly associated with raised pressure in the eye (intraocular pressure \[iop\]). iop has been shown to increase when lying down in normal subjects as well as patients with glaucoma. it is possible that this effect can make glaucoma worse. this study is designed to investigate the effect of body posture (particularly when sleeping) on the iop fluctuation in the eye. each patient will be required to attend for 2 separate 24 hour visits. on one visit the patient will be required to sleep flat and on the other visit at a 30° head up sleeping position. during this time the patient will be required to wear a soft contact lens (sensimed triggerfish®) which has a special sensor on it that monitors the iop continuously. the iop measurements are wirelessly transmitted to a recorder.


Eligibility criteria:
inclusion criteria: * signed informed consent * diagnosis of primary open angle glaucoma (poag) or normal tension glaucoma (ntg) that is progressing based on recent or recurrent optic disc hemorrhage * age 18-85 years * not more than 4 diopters of spherical equivalent or 2 diopters of cylinder equivalent in study eye * stable anti-glaucoma treatment for 4 weeks before first session * for women of childbearing potential, adequate contraception exclusion criteria: * unwilling or unable to sleep in a flat or 30 degrees head up position * ocular surgery in previous 3 months * corneal or conjunctival abnormality * wear of full frame metallic glasses during monitoring session * severe dry eye * secondary forms of glaucoma * allergy to corneal anaesthesia * patients with contraindications for contact lens wear * pregnancy and lactation * patients unable to understand the character and individual consequences of the investigation * simultaneous participation in other research

Keywords: intraocular pressure contact lens sensor optic disc hemorrhage
screen to save: a colorectal cancer educational intervention

Conditions: Colorectal Cancer

Summary: the purpose of this research is to understand if an educational program about colorectal cancer helps improve people's knowledge of colorectal cancer prevention and screening and their intention to get screened for colorectal cancer.


Eligibility criteria:
inclusion criteria: * age: 50-74 years old * attendee at event where educational module is offered

Keywords: knowledge