lung cancer exercise training study

Conditions: Lung Cancer

Summary: the purpose of the study is look at the effects of different types of exercise training with a stretching group and its effect on lung cancer patients. subjects will take part in a 16 week training intervention that can consist of aerobic, resistance, aerobic \& resistance, or a control group. pre and post testing will include stress tests, echos, blood, and urine samples.


Eligibility criteria:
inclusion criteria: * signed informed consent prior to initiation of study-related procedures * age 21 - 80 years * weight \< 205 kgs * ecog ≤ 1 * diagnosed with histologically confirmed lung cancer, regardless of disease stage and receiving any prior line of any therapy in the context of metastatic disease * an interval of at least three months following the completion of primary resection, if appropriate * an interval of no longer than ten years following completion of primary therapy, if appropriate * life expectancy ≥ 4 months * performing less than 150 minutes of structured moderate-intensity or strenuous-intensity exercise per week * exercise intolerance (i.e., patients must have a vo2peak below that predicted for active age and sex-matched individuals) * willing to be randomized to one of the study arms * willing to commit to the study program and comply with all related protocol procedures * able to achieve an acceptable peak baseline cpet, as defined by any of the following criteria: * achieving a plateau in oxygen consumption, concurrent with an increase in power output; * a respiratory exchange ratio ≥ 1.10; * attainment of maximal predicted heart rate (hrmax) (i.e., within 10 bpm of age-predicted hrmax \[hrmax = 220-age\[years\]); * volitional exhaustion, as measured by a rating of perceived exertion (rpe) ≥ 18 on the borg scale. * able to complete an acceptable baseline cpet in the absence of high risk ecg findings or other inappropriate response to exercise as determined by the pi. * ability to achieve and complete an acceptable baseline one-repetition maximum muscular strength test as defined by the effective execution of protocol-specific joint and muscle ranges of motion without remarkable signs or symptoms of pain, discomfort or distress. exclusion criteria: * presence of a concurrent, actively treated other malignancy, or history of other malignancy treated within the past 3 years (other than non-melanoma skin cancer); * room air desaturation at rest ≤ 85%; * mental impairment leading to inability to cooperate. * any of the following absolute contraindications to cardiopulmonary exercise testing: * acute myocardial infarction (within 3-5 days of any planned study procedures); * unstable angina; * uncontrolled arrhythmia causing symptoms or hemodynamic compromise; * recurrent syncope; * active endocarditis; * acute myocarditis or pericarditis; * symptomatic severe aortic stenosis; * uncontrolled heart failure; * acute (within 3 months) pulmonary embolus or pulmonary infarction; * thrombosis of lower extremities; * suspected dissecting aneurysm; * uncontrolled asthma; * pulmonary edema; * respiratory failure; * acute non-cardiopulmonary disorders that may affect exercise performance or be aggravated by exercise (i.e., infection, renal failure, thyrotoxicosis)

Keywords: exercise intervention lung cancer 15-215