Kornimate/medical-research-clean huggingface dataset:
study of various insoles in patients with knee osteoarthritis

Conditions: Osteoarthritis, Knee

Summary: it is critical to improve our understanding of knee osteoarthritis and to design better therapeutic options for this disease. the function of the knee during walking is an important factor in the development and progression of the disease. many models of insoles that can be inserted in regular shoes with the objectives of improving the function of the knee are available on the market without prescription. prior studies on these insoles failed to report clear benefits for the patients, mainly because the results varied strongly between persons. walking is a complex tasks and it is well known that everybody develops his/her individual way of walking (ie., there are subtle but very important differences in the function of the knee). this observation and the fact that patient responses could vary between individuals suggest that using the same standard insoles with all patients might not be appropriated. this further suggests that care could be greatly improved if it was possible to identify patients that would respond positively to a model of insoles. unfortunately, while several randomized controlled trials were conducted on these insoles for knee osteoarthritis, there is a paucity of data regarding their effects on the ambulatory function of the knee. therefore, this study aims to improve the understanding regarding the effects of insoles freely available on the market in terms of knee mechanics during walking and its relation with quality of life. this study will test the hypotheses that (i) insoles have an effect on the static and dynamic lower-limb function and (ii) that benefits perceived by the patients are related to the mechanical effects produced by the insoles.


Eligibility criteria:
patients with knee osteoarthritis inclusion criteria: * knee x-ray with less than a year * medial compartment knee osteoarthritis * varus knee between 0 and 10 degrees exclusion criteria: * neurological impairments * prior lower-limbs surgery * joint injection during the last six months * convergent patella control subjects inclusion criteria: * no lower-limbs or spine osteoarthritis * no pain during ambulation exclusion criteria: * neurological impairments * prior lower-limbs surgery or current treatments
activity and health in nursing homes

Conditions: Old Age; Frailty

Summary: there is expected to be an increased need for full time nursing homes as the increase in number of older adults increases and the rate of dementia diagnosis happens simultaneous with the decrees of healthcare personnel the years to come. a lift in knowledge is needed to provide a better and more efficient healthcare to be better equipped to meet this societal challenge. physical activity and sleep are important indicators of health, but also on effect of treatment and care for this frail population. comprehensive mapping of personnel time spent on different tasks and older adults' physical function throughout a week gives a unique opportunity to gain new knowledge about everyday life in nursing homes. the main aim of this project is to describe associations between physical behavior, sleep and symptoms in residents in nursing homes in trondheim municipality and combine these with personnel time spent on different working tasks.


Eligibility criteria:
inclusion criteria: all residents in nursing homes in trondheim municipality. exclusion criteria: terminal residents or residents that can not stand or walk a few steps independently.

Keywords: nursing home physical activity
does the disinfection of the subcutaneous tissue reduce the contamination of the operative field by p. acnes during primary shoulder surgery?

Conditions: Shoulder Surgery

Summary: propionibacterium acnes is a pathogen frequently identified during postoperative infections of the shoulder. a recent study has shown that p. acnes is likely to be disseminated in the operative field from the subcutaneous layer by soft tissue manipulation by the surgeon and the instruments (falconer 2016). this study seeks to evaluate the effectiveness of subcutaneous tissue disinfection on p. acnes contamination during primary shoulder surgery. the literature shows that approximately one-third of patients have a p. acnes-infected surgical drape during primary shoulder arthroplasty (falconer 2016). the source of this contamination would be the subcutaneous tissue. the hypothesis is that a disinfection of the subcutaneous tissue would reduce the contamination of the operative field with the aim of reducing the infection rate after shoulder surgery.

it is a randomized, single-center, open-label, category a clinical trial, a research project on people involved in the collection of biological material and the collection of health-related personal data with the existence of consent. the investigators will study the effectiveness of betadine subcutaneous tissue disinfection during primary shoulder surgery. they will randomize 105 patient on two arms. the control group receiving no disinfection of the subcutaneous tissue (a) and intervention group, receiving disinfection of the subcutaneous tissue (b). the investigators estimate that 4 years is enough to recruit the number of patients needed for this study. all patients 18 years of age or older admitted to the valais hospital to receive primary shoulder surgery and who have signed the consent of the study will be eligible.

Eligibility criteria:
inclusion criteria: 1. = or\> 18 years 2. supported at the valais hospital for primary surgery of the shoulder. 3. have signed the consent exclusion criteria: 1. \<18 years old 2. history of shoulder surgery 3. history of infection of the shoulder 4. antibiotherapy in the 2 weeks preceding the intervention 5. infiltration of cortisone in the 6 months preceding the intervention 6. iodinated contrast medium allergy or cefuroxime 7. allergy to the povidone iodine complex or other contraindication to betadine namely: hypersensitivity to the active ingredient, iodine or povidone iodine complex, or to any of the excipients according to the composition. hyperthyroidism and other overt thyroid diseases. dermatitis herpetiformis of duhring. before and after radioactive iodine treatment (until the end of treatment) 8. refusal of the terms of the study
aortic cross clamping time, and postoperative respiratory function

Conditions: Bypass Complication; Respiratory Complication

Summary: does the duration of cardiopulmonary bypass, and aortic cross clamping affects the post operative pulmonary function.

cardiac surgery usually is done under cardiopulmonary bypass. as the blood contacts with the artificial tubing of the circuit, there is release of mediators which affects pulmonary function. of no doubt that the duration of cardiopulmonary bypass, and cross clamping time, will affect the spell over of such mediators. follow up of the pulmonary function, and arterial blood gas is mandatory in such group of patients.

Eligibility criteria:
inclusion criteria: * adult patients * elective open heart surgery exclusion criteria: * patients with myocardial ischemia or previous infarction * low ejection fraction \<30% * history of af * implanted pacemaker * uncontrolled hypertension * renal impairment (creatinine \>1.8 mg/dl) * hepatic dysfunction * insulin dependent diabetes * chronic pulmonary disease
effect of a vibratory stimulus on mitigating nociception-specific responses to skin puncture in neonates

Conditions: Infant, Newborn; Infant, Premature; Pain Perception; Pain Measurement; Pain Management; Electroencephalography

Summary: the assessment and treatment of pain in neonates remains a challenge. in an effort to improve the quality of care while limiting opioid-related adverse effects, this study aims to determine the efficacy of a non-pharmacological intervention on the mitigation of nociception-specific responses to a skin breaking procedure in term and preterm neonates. such responses will be measured using behavioral measures as well as with electroencephalography-based methods.

eligible neonates who are 36-56 weeks post-menstrual age and who are scheduled to undergo a clinically required heel lance will be studied after obtaining appropriate verbal and written consent from the respective parents. subjects will be monitored during a baseline resting state, during vibratory stimuli alone, and during a heel lance that is randomized to be preceded or not preceded by the vibratory stimulus. the sessions will include time-locked video recordings and electroencephalography using a specialized net of 128 electrodes (electrical geodesics inc., egi; eugene, or). behavioral and cortical responses will be then be analyzed in a blinded fashion to determine the efficacy of the vibratory intervention, as well as to validate what behavioral responses are most correlated with nociception-specific cortical activity.

Eligibility criteria:
inclusion criteria: * neonatal intensive care unit patient * between 36 to 56 weeks post-menstrual age * medically stable * due to have a clinically required bedside heel stick as part of their routine care exclusion criteria: * congenital anomalies or abnormalities affecting the brain * patient is over 4 months corrected age * infants who receive analgesics or sedatives within 72 hours prior to assessment * administration of maternal analgesics or sedatives to which the infant may be exposed
imfinzi specific-clinical experience investigation in patients with nsclc after definitive chemoradiation therapy

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: to investigate the impact of presence/absence or grade of radiation pneumonitis before starting imfinzi, on the onset of interstitial lung disease (including radiation pneumonitis) after starting imfinzi, in the real world in patients with locally advanced unresectable non-small cell lung cancer who are treated with the product as maintenance therapy after definitive chemoradiation therapy.


Eligibility criteria:
inclusion criteria: -patients with locally advanced unresectable non-small cell lung cancer who are treated with imfinzi for the first time as maintenance therapy after definitive chemoradiation therapy exclusion criteria: -no past history of hypersensitivity to the components of imfinzi

Keywords: lung diseases, interstitial radiation pneumonitis
a prospective study of tocilizumab in the treatment of idiopathic retroperitoneal fibrosis

Conditions: Idiopathic Retroperitoneal Fibrosis

Summary: this is a prospective study to investigate the treatment response of tocilizumab on patients with idiopathic retroperitoneal fibrosis（irpf）. methods: all the patients fulfilling diagnostic criteria of irpf would be enrolled. the irpf patients will accept tocilizumab or glucocorticoid monotherapy for 3 months. endpoints: the primary endpoint is to investigate the response of tocilizumab on irpf patients; the secondary endpoints include the decrease of inflammatory markers, side effect.


Eligibility criteria:
inclusion criteria: * age 18-75 diagnosed as irpf: the diagnosis of idiopathic retroperitoneal fibrosis is based on the following aspects :(1) the swelling of retroperitoneal tissue , which seems neoplastic; (2) a large number of lymphocytes proliferated and infiltrated in the affected tissues and organs, and tissues showed inflammation, fibrosis and sclerosis, in which igg4-positive cells accounted for less than 50% of plasma cells; (3) increased inflammatory markers, such as esr and crp; (4) good response to glucocorticoid therapy. exclusion criteria: * malignancy retroperitoneal fibrosis secondary to other diseases or drug treatment or abdominal surgeries.

Keywords: idiopathic retroperitoneal fibrosis tocilizumab response
specimen collection for individuals with lung disease associated with rheumatoid arthritis

Conditions: Pulmonary Fibrosis; Rheumatoid Arthritis

Summary: pulmonary fibrosis (pf) is a condition in which the lungs of a patient become scarred and fibrous. it has been known to occur in as many as 40% of patients diagnosed with rheumatoid arthritis (ra). the cause of the pulmonary fibrosis in patients with ra is unknown. researchers hope to improve their understanding of the disease process involved in pf and ra by analyzing specimens collected by bronchoscopy, lung biopsy, lung transplantation, or autopsy from patients with these conditions. the purpose of this study is to collect specimens from rheumatoid arthritis patients with and without pulmonary fibrosis as well as patients with pulmonary fibrosis without associated diseases or cause (idiopathic pulmonary fibrosis).

the etiology of pulmonary fibrosis in individuals with rheumatoid arthritis is unknown. analysis of blood and specimens procured by bronchoscopy, lung biopsy, lung transplantation, or post-mortem examination from patients with this disorder will contribute to our understanding of the pathogenetic mechanisms of pulmonary fibrosis in rheumatoid arthritis. the purpose of this protocol is to obtain blood and specimens by bronchoscopy, lung biopsy, lung transplantation, or post-mortem examination from rheumatoid arthritis patients with and without pulmonary fibrosis, individuals with idiopathic pulmonary fibrosis, and healthy research volunteers.

Eligibility criteria:
* inclusion criteria: non-smokers (never smoked or not smoked within the previous 2 years) who are 18 years of age or older with any of the following: ra with pf (biopsy-proven), or ra-only, or idiopathic pf-only (biopsy-proven), or healthy research volunteers by history and indicated tests (individuals without history of chronic cardiopulmonary disorder, collagen vascular disease, or bleeding disorder) matched for age (within 5 years) and gender. exclusion criteria: individuals with any of the following: forced expiratory volume in one second (fev(1)) less than 1l. inhalational exposure to fibrogenic fibers or dusts (i.e., asbestos, silica, coal, beryllium). chronic cardiopulmonary disorders other than pulmonary fibrosis. other collagen vascular disorders (i.e., systemic lupus erythematosus, scleroderma, polymyositis, mixed connective tissue disease). non-rheumatoid arthritis. viral infections associated with pf (i.e., hepatitis b, hepatitis c, human immunodeficiency virus). uncorrectable bleeding diathesis. pregnancy or lactation.

Keywords: bronchoscopy idiopathic pulmonary fibrosis proteases fibroblast proliferation reactive proteins rheumatoid arthritis pulmonary fibrosis
mindfulness-based stress reduction and the microbiome

Conditions: Posttraumatic Stress Disorder; Irritable Bowel Syndrome

Summary: this proposed study aims to determine whether decreasing stress levels in persons with posttraumatic stress disorder (ptsd) can lead to a change in the intestinal microbiota, assessed 8 weeks after enrollment.

the gut microbiota is known to be integral to gastrointestinal health and disease. psychological stress has been shown to significantly alter the gastrointestinal microbiota of rats, rhesus monkeys, and humans. these studies have consistently shown decreases in lactobacilli among other changes in species that correlate with an increase in diarrheal symptoms. while it is unclear whether stress causes diarrhea leading indirectly to a disruption in the native microbiota, or whether stress leads directly to changes in the microbiota that then lead to diarrhea; there is a growing body of evidence to support the latter. differences in microbiota have also been shown to be present in irritable bowel syndrome (ibs) and predispose or protect against other forms of diarrhea including bacterial gastroenteritis and radiation-induced diarrhea. in addition, treatment with probiotics containing lactobacillus and other species has been shown to help alleviate ibs symptoms. stress is hypothesized to act on the microbiota via the brain-gut axis through endocrine, immunological, and/or neurological pathways. this proposed study aims to determine whether decreasing stress levels in persons with posttraumatic stress disorder (ptsd) \& ibs can lead to a change in the intestinal microbiota, assessed 3 weeks after enrollment. it also seeks to determine if a change in intestinal microbiota correlates with a decrease in ibs symptoms. we propose to use broad-range bacterial 16s rrna gene pcr with 454 pyrosequencing to characterize the fecal microbiota and correlate changes in bacterial communities to ibs symptoms at baseline and after completion of an 8-week-stress reduction course in 15 patients with ptsd \& ibs and to compare these findings to 5 patients with ptsd \& ibs undergoing usual care without a stress-reduction course.

Eligibility criteria:
inclusion criteria: * posttraumatic stress disorder exclusion criteria: * psychosis * suicidal ideation with intent

Keywords: posttraumatic stress irritable bowel
a study of the effects of external stimulations on postural stability

Conditions: Postural Stability

Summary: in view of the long-term exercise, you can maintain your health and strengthen your physical strength. it can also improve your body's balance and help maintain your body's coordination so that you can reduce the chance of falls. therefore, in the face of aging, stroke rehabilitation or balance of power caused by balance of power decline, sports injuries or falls related issues, this study will focus on "balance ability" to explore a range of impacts and relationships.

considering the standardization comparison in the study, this study will collect data on the balance of young people under different external stimuli, and hope to understand the balance control ability by objectively collecting the physiological signals of the center of pressure (cop). the change, and the use of the berg scale as a benchmark for the assessment of balance ability, and then return to the issue of balance ability training. therefore, this study divides the experiment into two major stages. the first stage will focus on healthy young people, and explore how external stimuli affect balance, and then assist balance ability training to find the most appropriate adjustment of body posture control. the second phase explores the appropriate exercise training for stroke patients, such as the use of modular interactive tiles system (mits) training, to track the effectiveness of external stimulus impact balance training.

Eligibility criteria:
inclusion criteria: * stage1 subjects were included in the condition of adults with good health and no mobility disorder. they will be considered by healthy young people over the age of 20. it is estimated that 12 males and 12 females will be called. * stage2 forty patients with a stroke of more than six months have been admitted. subjects were included as follows: 1. stroke for more than 6 months; 2. current stable condition; 3. able to walk independently for more than 5 meters, and if necessary, use auxiliary equipment; 4. before and after the two feet stand in a straight line for more than 10 seconds; 5. can understand spoken instructions. exclusion criteria: * stage1 1. unable to stand with the feet and the walker; 2. pregnant; 3. within six months will affect the walking or standing surgery (such as limbs, spine or brain surgery); 4. other physical and mental state is not suitable. * stage2 1. unable to stand and walk with both feet; 2. suffering from diabetes or other diseases combined with peripheral neuropathy, causing a poor sense of body or a neurological disease affecting lower limb movement and sensory function; 3. suffering from hemophilia patients with diseases, other blood-related diseases or severe peripheral vascular diseases; 4. those who are pregnant; 5. those who have been affected by walking or standing within six months (such as limb, spine or brain surgery); 6. other physical and mental states are not suitable.

Keywords: modular interactive tiles system, mits stroke
xm-one study for living donor program

Conditions: Transplant; Failure, Kidney

Summary: donor-specific antibody (dsa) (hla) levels and non-hla antibody levels in recipients prior to living kidney transplantation and randomize these individuals into a desensitization protocol in order to evaluate shifts that can occur with the luminex and xm-one assay after treatment and up to 6 months post transplant. if desensitization is needed prior to transplantation in individuals with a negative crossmatch but positive dsa and/or xm-one - patients will be evaluated clinically with routine lab tests (serum creatinine levels, spot urine protein and spot urine creatinine levels) as well as protocol biopsy evaluations.

1. rates of acute rejection including subclinical rejection - acute t cell mediated (cellular) rejection, antibody mediated acute rejection, and chronic antibody-associated injury (i.e.: transplant glomerulopathy, chronic allograft arteriopathy) between the groups. 2. evaluation of endothelial cell activation and injury on biopsies by checking markers for endothelial cell activation and injury (intercellular adhesion molecule-1, icam-1/cd54; vascular cell adhesion molecule-1, vcam-1/cd106; and e-selectin, elam-1/cd62e) in two-color stains of tissue with classical endothelial markers (cd34 and factor viii). 3. measurement of serum/plasma levels of tnf-alpha and vegf and decreased levels of protein c and protein s in the circulation, as an assessment of graft vascular perturbation. 4. circulating endothelial cells (cecs) will be measured by flow cytometry with markers for endothelial cell activation.

Eligibility criteria:
inclusion criteria: * recipients receiving deceased donor transplants. * living donor transplant that is t-cell flow crossmatch positive. * hiv, hepatitis c and b positive patients. exclusion criteria: * pregnant women and children will be excluded from the study.
optical coherence tomography of tear film dynamics in-vivo

Conditions: Dry Eye Disease

Summary: the purpose of this study is to evaluate a new instrument that takes digital images of tear film (a thin film that coats the eye that is made up of oil and water). the investigators are interested in measuring how the thickness of the tear film varies through time. the goal is to develop a technique that may enable non-invasive evaluation of dry eye disease for future clinical diagnosis.


Eligibility criteria:
inclusion criteria: * clinically diagnosed dry eye disease * normal individuals (those without a dry eye diagnosis and without eye abnormalities) * good general health (defined by medication use that has not changed within the last month and the absence of medical conditions that are deemed confounding to the data as determined by the pi) * ability to give informed consent * willing to spend time for the study * either gender * any racial or ethnic origin exclusion criteria: * use of any prescription ocular medication (such as but not limited to, glaucoma medications and restasis) used within 14 days of the study visit * current eye disease, infection or inflammation that affects the surface of the eye such as, but not limited to blepharitis and ocular allergy * past eye surgery, such as, but not limited to, refractive surgery. subjects who have had cataract surgery less than one year ago * use of soft or hard contact lenses 6 hours prior to visit * female subjects may not be pregnant or lactating (subjects will be asked to self-report these conditions) * infectious diseases (for example, hepatitis, tuberculosis) or an immuno-suppressive disease (for example, hiv) (subjects will be asked to self-report these conditions)