Kornimate/medical-research-clean huggingface dataset:
increased microcirculation for preventing postoperative wound infections in patients undergoing reduction mammoplasty

Conditions: Surgical Side Infections After Breast Reduction

Summary: in this prospective study we investigated the impact of an improved postoperative microcirculation and its effect of surgical side infections after breast reduction.

many studies identifying risk factors for surgical side infections (ssi) after breast surgery included a large percentage of breast conserving therapies and risk factors for patients undergoing more extensive procedures like breast reduction (br) are underrepresented and risk factors for more extensive breast surgeries might not be identified. our approach to decrease ssi after br was the application of an i.v. isotonic crystalloid solution, 6% hydroxyethylstaerke (hes) as a diminished peripheral blood flow and impaired vasculogenesis are characteristics of poorly healing wounds. hes causes a medium- to long-term increase in blood volume, blood flow and improved blood oxygen transport. blood flow and tissue oxygenation are parts of regulating the healing process by utilizing molecular oxygen as a terminal oxidant. this antioxidant capacity can influence the wound healing process positively, as a characteristic feature of the inflammatory phase is the oxidative burst. hes additionally decreases haematocrite, blood viscosity and aggregation of erythrocytes positively influencing the complex components regulating wound healing. these characteristics and the increase in blood circulation might influence the postoperative healing and regeneration process.

Eligibility criteria:
inclusion criteria: * eligible patients were at least 18 years of age, scheduled for breast reduction, guaranteed follow-up of 30 days. exclusion criteria: * patients were excluded if they had a history of coagulopathy or history of antiplatelet agent use within 10 days of surgery

Keywords: surgical side infection breast reduction reduction mammaplasty prospective trial microcirculation breast surgery
long term safety of spa100 (fixed-dose combination of aliskiren/amlodipine) in patients with essential hypertension

Conditions: Essential Hypertension

Summary: the purpose of this study is to evaluate the long-term safety and tolerability of the combination of aliskiren and amlodipine given to patients with essential hypertension. this study is being conducted to support registration of the fixed combination of aliskiren/amlodipine in the treatment for hypertension in japan.


Eligibility criteria:
inclusion criteria: * patients that complete cspa100a1301 study * patients whose blood pressure at visit 7 of cspa100a1301 study must be well controlled exclusion criteria: * patients who experienced any serious adverse events considered drug related in cspa100a1301 study * presence of major protocol violation in cspa100a1301 study other protocol-defined inclusion/exclusion criteria may apply

Keywords: aliskiren amlodipine essential hypertension long term
effectiveness of using interactive consulting system to enhance decision aids of covid-19 vaccination

Conditions: COVID-19

Summary: to evaluate the performance of an interactive chatbot and assess its effectiveness for enhancing informed decisions made by cataract patients.


Eligibility criteria:
inclusion criteria: * individuals aged over 18 years who have been resident in the selected study district for more than six months; * willing to participate the study and provide informed consent. exclusion criteria: * having ocular, hearing or mental disorders precluding reading or telephone interview.
recovering arm function in chronic post-stroke patients using combined hd-tdcs and virtual reality therapy

Conditions: Chronic Post Stroke Individuals

Summary: the study aims to determine the added value of combining high-definition transcranial direct current stimulation (hd-tdcs) in a rehabilitation program based on virtual reality therapy (vrt) to potentiate the effects on neuroplasticity and further improve functional recovery of the arm in chronic stroke patients.

stroke remains the leading cause of acquired disability in france. moreover, even after the first 3 months of intense arm rehabilitation, 80% of chronic stroke patients don't use their paretic arm in activities of daily living. to this day, despite notable developments, techniques of rehabilitation of the arm for chronic stroke patients are still insufficient. in this context, two promising stroke rehabilitation techniques are to be considered: * virtual reality-based systems provide specific, intensive, repetitive and motivational therapy with real-time feedback of movement and performance which can promote activity-dependent brain neuroplasticity, and therefore functional arm recovery. thus, virtual reality therapy (vrt), in addition to usual rehabilitation, would improve the function of the arm more effectively as well as daily activities. * non-invasive transcranial direct current stimulation (tdcs) uses constant low intensity (2 ma) continuous electrical currents to modulate the excitability of cortical neurons. because of its greater focality of neuromodulatory effect that promotes brain neuroplasticity, anodal hd-tdcs to the lesioned hemisphere can improve functional arm recovery after a stroke. in addition, the combined use of the hd-tdcs with a rehabilitation modality, such as constraint induced movement therapy, would potentiate the combined effects of both techniques. therefore, the investigators hypothesize that the combination of hd-tdcs in a rehabilitation program based on vrt would potentiate the effects on neuroplasticity and would further improve functional recovery of the paretic arm in chronic stroke patients

Eligibility criteria:
inclusion criteria: * patient aged 18 to 90 * patient with more than 3 months of a first cerebrovascular accident whatever the aetiology * patient with paresis of the upper extremity (fm-ue ≥ 15) exclusion criteria: * failure to collect written informed consent after a period of reflection * not be affiliated with a french social security scheme or beneficiary of such a scheme * major deficit of the upper extremity (fm-ue \<15) * history of epilepsy * presence of a pacemaker or a metallic object implanted in the head * pregnant or lactating * severe neglect or attention deficit disorder (omission of more than 15 bells in the bell's test) * severe cognitive impairment (mini mental score \<24) * aphasia with impairment of understanding (boston aphasia quotient \<4/5) * under guardianship or curatorship * protected by law

Keywords: stroke hd-tdcs virtual reality therapy physical therapy
the effect of massage on the bilirubin level in term infants receiving phototherapy

Conditions: Hyperbilirubinemia, Neonatal

Summary: background: it has been reported in the current literature that massage has various positive physiological effects on the newborn. also baby massage; it increases the collection and excretion of waste products such as bilirubin by accelerating the flow of blood, lymph and tissue fluids. our aim is to investigate the effect of infant massage on hyperbilirubinemia in newborns receiving phototherapy. method: the population of the study consisted of babies who were hospitalized in istanbul haseki training and research hospital neonatal intensive care unit between october 2021 and january 2022 and needed phototherapy. transcutaneous bilirubin device and data collection form were used to obtain the data. 61 newborns who met the study criteria were randomly divided into experimental (n=30) and control (n=31) groups. phototherapy was applied to all babies twice a day. in addition to phototherapy, infant massage was applied to the experimental group for 10 minutes just before the phototherapy. bilirubin level measurements were made 2 hours after the end of phototherapy for both groups. diaper changes for both groups were carried out 8 times a day, every 3 hours.


Eligibility criteria:
inclusion criteria: * born between 37-42 gestational weeks * birth weight between 2500-4000gr * 1st and 5th apgar score between 7-10 * needing phototherapy treatment * diagnosed with indirect hyperbilirubinemia 24 hours or more after birth * orally fed * no health problems other than indirect hyperbilirubinemia * newborns who has stable vital signs exclusion criteria: * abo blood incompatibility or rh incompatibility * diagnosed with direct hyperbilirubinemia * newborns who has skin anomaly * needing fluid replacement * newborns with gastrointestinal disorders

Keywords: infant baby massage hyperbilirubinemia bilirubin
diagnosis of parkinson´s disease by means of submandibular gland needle biopsy

Conditions: Parkinson Disease

Summary: this study includes 35 pd patients who underwent submandibular gland needle biopsy. 25 neurologically healthy patients of the local otolaryngological clinic, in whom submandibular gland needle biopsy was performed due to a clinical indication, serve as controls.

parkinson´s disease (pd) is a neurodegenerative disease which is characterized by a pathological aggregation of α-synuclein. this pathological α-synuclein aggregation results in the formation of lewy bodies which are used for the histopathological diagnosis of pd. neuropathological post mortem studies showed that pathological aggregations of α-synuclein may occur also outside the central nervous system in pd, for example in the cardiac plexus, in the major salivary glands and the innervating cervical superior ganglion, in the minor salivary glands, in the adrenal glands and in the mesenteric and pelvic plexus. the finding of pathologically aggregated α-synuclein in the major salivary glands offers the possibility to prove pd intra vitam by means of a small transcutaneous biopsy. a recent post mortem study in the local department of neuropathology found, that there was pathologically aggregated α-synuclein in 12 of 14 patients with diagnosed and neuropathologically confirmed pd, whereas there was no pathologically aggregated α-synuclein in 13 persons without pd. the present study includes 35 pd patients who underwent submandibular gland needle biopsy. 25 neurologically healthy patients of the local otolaryngological clinic, in whom submandibular gland needle biopsy was performed due to a clinical indication, serve as controls. immediately after the biopsy, the obtained submandibular gland tissue is transported to the local department of neuropathology for histopathological analysis.

Eligibility criteria:
inclusion criteria: major patients with parkinson´s disease (pd) exclusion criteria: * missing consent to participation in the study * pregnancy * indigestibility against local anesthetic * increased risk of bleeding * therapy with an anticoagulant

Keywords: alpha synuclein
vibrational spectroscopy for endometrial cancer diagnosis

Conditions: Endometrial Cancer; Endometrial Hyperplasia

Summary: the purpose of this study is to investigate the ability of vibrational spectroscopic techniques, raman spectroscopy and attenuated total reflection - fourier transform infrared spectroscopy (atr-ftir), to accurately differentiate endometrial tissue, lymph nodes and blood samples with womb cancer or endometrial hyperplasia from healthy controls.

womb cancer is the sixth most common cancer in women, with rising incidence worldwide. current diagnostic strategies are time consuming, invasive and have limited accuracy, furthermore there is no population-wide screening. treatment depends on patients' health, type of disease and spread at the time of diagnosis. most women will be offered surgery, however the role of lymph node dissection in early stage disease remains controversial. there is therefore a need for an objective, accurate test, able to detect pre-cancer and cancer early and able to identify metastatic node involvement, so that lymph node excision is performed only when necessary. attenuated total reflection - fourier transform infrared (atr-ftir) spectroscopy and raman spectroscopy are non-invasive, objective techniques that use the interaction of light within tissues to gain detailed information about the chemical composition of biological samples. these methods have shown tremendous potential for improving diagnosis and treatment of cancer. this study aims to use vibrational spectroscopy to examine blood plasma and serum, endometrial biopsies via pipelle device and pelvic/para-aortic lymph nodes for the presence of endometrial pre-cancer and cancer changes. the analyses will be performed on fresh (wet) as well as dried samples. the ultimate goal is to develop a point-of-care test and an intra-operative tool for endometrial cancer screening and diagnosis. such a test could speed up endometrial cancer diagnosis, reduce treatment delays and individualise patients care.

Eligibility criteria:
inclusion criteria: 1. endometrial cancer group: * established histopathological diagnosis of cancer of the endometrium (any stage and subtype) * patients must be eligible for primary staging surgery (any route, e.g. laparoscopy and laparotomy) 2. endometrial hyperplasia group: * established histopathological diagnosis of endometrial hyperplasia (with or without atypia) * treatment with hysterectomy deemed necessary 3. control group * healthy with benign disease, non-malignancy * undergoing hysterectomy (any route, e.g. laparoscopy and laparotomy) exclusion criteria: * patient's refusal / inability to consent * synchronous gynaecological cancer (ovary, cervix, fallopian tubes) * previous pelvic radiotherapy * previous hysterectomy * undiagnosed vaginal bleeding * previous endometrial ablation

Keywords: endometrial cancer uterine neoplasm cancer of the endometrium spectroscopy raman spectroscopy fourier transform infrared spectroscopy endometrial hyperplasia
phosphate metabolites in brain of humans aged 50+

Conditions: Basic Science

Summary: the objective of this research project is to determine in elderly subjects (\>50 year old) by 31p-mrs the brain concentration of phosphorous metabolites species and fluxes, before and after consumption of 2 commercially available oral nutrition products


Eligibility criteria:
inclusion criteria: * men and women aged between 50 and 75 years * healthy, based on the medical screening visit * normal bmi for age (18.5-29.9 kg/m2) * able to understand and to sign a written informed consent prior to trial entry * informed consent signed exclusion criteria: * known type 1 or type 2 diabetes, on anamnesis * family history of type 2 diabetes (parents) * any other metabolic disease possibly impacting the postprandial glucose and insulin response (on anamnesis, to the opinion of the medical expert) * malabsorptive disorders including but not limited to pancreatitis, crohn's disease, etc, to the opinion of the medical expert * any ongoing medication impacting dietary fat absorption and metabolism like statins, bile acid sequestrants, lipid lowering medications, or fibrates , to the opinion of the medical expert * any ongoing medication impacting the postprandial glucose and insulin response (like beta blockers), to the opinion of the medical expert * any ongoing medication impacting brain metabolism or function (neuroleptics, antidepressants, anti-epileptics), to the opinion of the medical expert * ongoing chemotherapy * any food supplement intake (e.g. mct, ketone salts = calcium, sodium, potassium, magnesium) or special diet (e.g. ketogenic diet) possibly impacting basal ketone levels, to the opinion of the medical expert. * claustrophobia * hearing disorders (the participant placed into the mrs tunnel should be able to hear from the operators, for safety purpose) * having any metallic, electronic, magnetic, or mechanical implants, devices, or objects, for safety reason linked to magnetic field exposure (mrs): * aneurysm clip(s) * cardiac pacemaker * implanted cardioverter defibrillator (icd) * electronic implant or device * magnetically-activated implant or device * neurostimulation system * spinal cord stimulator * cochlear implant or implanted hearing aid * insulin or infusion pump * implanted drug infusion device, like portacath® for instance * any type of prosthesis or implant * artificial or prosthetic limb * any metallic fragment or foreign body * hearing aid * other implant * subject injured by a metallic object or foreign body * allergy to cow milk or soy proteins * currently participating or having participated in an investigational trial during the past month * subjects not willing and/or not able to comply with scheduled visits and the requirements of the research protocol. * subject having a hierarchical link with the investigator or co-investigators.
the role of imaging in the diagnosis, management and prognosis of possible non-convulsive status epilepticus

Conditions: Status Epilepticus; Ictal-interictal Continuum; Positron-emission Tomography; Perfusion Weighted MRI; Perfusion CT

Summary: the investigators propose a prospective study of 20 control subjects and 180 consecutive patients with possible non-convulsive status epilepticus (ncse). the investigators will obtain three functional images of the brain: 1. fluorodeoxyglucose positron emission tomography (fdg-pet) 2. perfusion (and structural) magnetic resonance (mr) images 3. computed tomography (ct) perfusion. brain hypermetabolism/hyperperfusion is a strong argument to confirm a diagnosis of non-convulsive status epilepticus. the aim is to determine which of the three functional imaging techniques is the most sensitive and easy to obtain in the detection of hypermetabolism/hyperperfusion. the investigators will determine which eeg patterns are associated with hypermetabolism/perfusion. the investigators will further study and describe the management with antiseizure medication and outcome of the group with possible non-convulsive status epilepticus with hypermetabolism/hyperperfusion versus the group with possible non-convulsive status epilpticus without hypermetabolism/hyperperfusion. the investigators will make recommendations for an imaging protocol in possible ncse for widespread use. the aim is to offer guidelines to incorporate imaging in the diagnosis, management and prognosis of ncse in patients with the ictal-interictal continuum.


Eligibility criteria:
inclusion criteria: - the patient has possible non-convulsive status epilepticus with scalp or invasive eeg with ictal-interictal continuum patterns on eeg exclusion criteria: * the patient has a contra-indication for mri such as metal implants * the patient has contrast sensitivity * the patiensuffers from claustrophobia or cannot tolerate confinement during pet-mri scanning procedures

Keywords: possible non-convulsive status epilepticus ictal-interictal continuum eeg mri fdg-pet ct perfusion
attenuating the post-operative insulin resistance and promoting protein anabolism

Conditions: Pre-Diabetes; Major Lung or Abdominal Surgery; Insulin Resistance

Summary: major surgery results in a stress- induced catabolic response, marked by post-operative insulin resistance, hyperglycemia and loss of body protein, which is associated with increased morbidity, mortality and adverse outcomes. there has been a great deal of research on different approaches to optimize post-operative insulin sensitivity including hormonal and nutritional interventions, minimally invasive surgical techniques and epidural anesthesia. however, the correlation between insulin resistance and body protein loss is not well understood. metformin is the most widely used insulin sensitizing and blood glucose-lowering drug in treatment of type 2 diabetic patients. this study will: 1) estimate the correlation between insulin resistance and body protein loss in pre-diabetic lung/colorectal resection patients; 2) investigate whether the post-operative metabolic state can be improved by the pre-operative administration of metformin; and assess the impact of metformin on surgical complications and hospital length of stay. the results of this study will provide insight into the relationship between insulin resistance and post-operative adverse events and potentially suggest a novel approach to improve outcomes using metformin, a drug already in wide clinical use.


Eligibility criteria:
inclusion criteria: 1. elective open anatomic lung resections: segmentectomy, lobectomy, bi-lobectomy 2. colorectal surgery for non-metastatic disease (including right, transverse, left, sigmoid, subtotal, total, and hemicolectomy) 3. primary or secondary lung cancer 4. at least 18 years of age with 5. hba1c 5.7- 6.5 % 6. not receiving any kind of glucose lowering medication. exclusion criteria: 1. already diagnosed with diabetes (hb a1c \> 6.5%) 2. are pre-diabetic receiving glucose lowering intervention ( any glucose lowering medication) 3. have renal or liver dysfunction (serum creatinine above 124 micromol/l in women and 133 micromol/l in men, bilirubin \>50 micromol/l) 4. will undergo extended resection of adjacent organs, chest wall resections, bronchoplasty, non-anatomic lung resections 5. will undergo pneumonectomy 6. non-elective operations 7. have mental conditions (e.g. dementia, disabling orthopedic and neuromuscular disease, psychosis), 8. have cardiac abnormalities, severe end-organ disease such as cardiac failure (new york heart association classes iii-iv), chronic obstructive pulmonary disease(copd), sepsis, morbid obesity (bmi \>40 kg/m2), anemia (hematocrit \< 30 %, hemoglobin \<100g/l albumin \< 25mg/dl) 9. have received steroids for longer than 30 days 10. have poor english or french comprehension.

Keywords: insulin resistance protein balance surgery post operative complications metformin pre-diabetes fasting blood glucose
risk factors of stroke or systemic embolism after atrial fibrillation ablation

Conditions: Atrial Fibrillation

Summary: to investigate the rate and risk factors of stroke or systemic embolism (se) following atrial fibrillation (af) ablation.

since catheter ablation for af reduces the burden of af effectively, several studies have demonstrated that catheter ablation not only improves the quality of life but also reduces the risk of stroke and all cause mortality. however, until now the guideline has recommended the continuation of oral anticoagulation (oac) therapy in patients who are at risk of stroke or systemic embolism (se) based on the cha2ds2-vasc score, even though they have sinus rhythm following catheter ablation. the aims of this retrospective study is to assess the rate of stroke/se during follow-up period after af ablation and identify the independent risk factors for stroke/se in patients who underwent catheter ablation for af.

Eligibility criteria:
inclusion criteria: * patients who underwent catheter ablation for af exclusion criteria: * none