Kornimate/medical-research-clean huggingface dataset:
the neural mechanisms of split-belt treadmill adaptation in people with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: majority of people with multiple sclerosis experience difficulty with balance and mobility, leading to an increased risk of falls. the goal of this clinical trial is to learn about brain activity during walking adaptation in people with multiple sclerosis. also, this clinical trial will test a form of nerve stimulation to see if it can improve walking performance. the main questions it aims to answer are: * what areas of the brain are the most active during walking adaptation? * can nerve stimulation make walking adaptation more effective? participants will walk on a treadmill where each leg will go a different speed which will create walking adaptation. at the same time, brain scans will occur. there will be two sessions of walking adaptation, one with nerve stimulation, and one without nerve stimulation. researchers will compare people with multiple sclerosis to healthy young adults to see if there are differences in brain activity.

most people with ms (pwms) experience significant gait asymmetries between the two legs leading to an increased risk of falls and musculoskeletal injury. the objective of this study is to investigate the neural mechanisms of gait adaptation and the effects of transcutaneous electrical nerve stimulation (tens) on adaptability during split-belt treadmill training in pwms. our hypothesis is that tens will strengthen sensorimotor integration via amplified afferent signaling, thereby enhancing adaptation, and further improving gait symmetry chronically. functional near-infrared spectroscopy (fnirs) will be used during a split-belt treadmill training paradigm to assess cortical activation during gait adaptation. additionally, the effect of split-belt treadmill training coupled with tens on gait adaptability in pwms will be tested with experimental and a sham tens split-belt treadmill sessions. cortical activation and the effect of tens on gait adaptability will be compared between young neurotypical adults and pwms to assess differences that can be attributed to multiple sclerosis.

Eligibility criteria:
inclusion criteria: * a diagnosis of relapsing remitting multiple sclerosis or a neurotypical adult (ages 18-86) * not experiencing an active relapse * able to stand and walk without an assistive device * able to walk for three tenths of a mile without stopping to rest exclusion criteria: * unable to walk for three tenths of a mile without assistance * musculoskeletal injury in past 6 months * lower extremity surgery in past 6 months * unable to abstain from medications that impair balance * currently pregnant * history of traumatic brain injury * history of vestibular disease * history of any other balance impairment unrelated to multiple sclerosis

Keywords: split-belt treadmill adaptation multiple sclerosis functional near-infrared spectroscopy cortical activation gait asymmetry locomotion sensorimotor control
a multidimensional study of premenstrual syndrome and body image

Conditions: Body Image; Premenstrual Syndrome; Sleep; Physical Inactivity

Summary: the goal of this cross-sectional study is to investigate the influencing factors of body image in women of reproductive age. the main question\[s\] it aims to answer are: * is there a connection between physical activity, body mass index and body image? * is there a connection between body image, premenstrual syndrome and sleep quality? participants will fill out a complex online questionnaire.

during the research, the researchers use a quantitative method, in which the participants fill out the knowledge of the female body scale, the global physical activity questionnaire, the body appreciation scale, the sleep quality scale and the premenstrual assessment form short form, as well as a general health status questionnaire. and a self-made questionnaire containing socio-demographic questions. in the course of the research, we form a sub-sample, on which we carry out further instrumental tests to monitor body composition and physical activity. the number of participants is approx. there will be 500 women between the ages of 18 and 45, who will be selected through targeted sampling. during the research, the data are processed in the spss v28.0 program and the following statistical methods are used: kolmogorov-smirnov and shapiro-wilk normality tests, spearman and pearson correlation analysis, pearson chi-square test, linear regression analysis. during the research, the safety of the participants and the ethical rules are strictly observed.

Eligibility criteria:
inclusion criteria: * women * between the ages of 18-45 years * regular menstruation exclusion criteria: * older than 45 years * pregnancy * amenorrhoea * premature ovarian failure

Keywords: physical activity premenstrual syndrome body mass index 24 hour movement behaviour sleep quality body image
nse ancillary study of the therapeutic hypothermia after nonshockable cardiac arrest trial.

Conditions: Cardiac Arrest; Hypothermia; Critical Care

Summary: cardiac arrest is at present a major cause of mortality as well as a cause of disability for the surviving victims.in europe, every year counts as 300,000 cardiac arrests responsible for 250,000 deaths. thus, less than 20 % of patients discharged home with impaired quality of life associated with symptoms of tiredness, stress, anxiety. the prognosis is related to the initial cardiac rhythm present during the initiation of resuscitation. recent progress in the improvement of mortality and neurological outcome has been achieved over the last decade thanks to the systematic implementation of a period of targeted temperature control between 32 and 34 ° c in patients who benefited from the realization of at least one electrical external shock. there are theoretical and clinical arguments to think that achieving the same way a period of targeted temperature control between 32 and 34 ° c in patients treated for cardiac arrest with a non- shockable rhythm on arrival can also benefit from this procedure. however other arguments are against this hypothesis including an increase in the risk of infection , worsening of the patient's hemodynamic status with no benefit to him. to answer this question, we conduce a randomized multicenter study testing the potential improvement of neurological outcome through this procedure targeted temperature control between 32.5 and 33.5 ° c in these patients. nse-ancillary study of hyperion trial will determine impact on neurospecific enolase (brain biomarker) of two temperature target for targeted temperature management (33°c or 37°c) after cardiac arrest in non-shockable rhythm.


Eligibility criteria:
inclusion criteria: * cardiac arrest in nonshockable rhythm and * glasgow coma scale score ≤8. in patients receiving sedative therapy at icu admission, the glasgow coma scale score assessed by the emergency physician just before sedative therapy initiation is used. * patient must be randomized in a center which participate in the ancillary study. exclusion criteria: * no-flow time \>10 min (time from collapse to initiation of external cardiac massage); * low-flow time \>60 min (time from initiation of external cardiac massage to return of spontaneous circulation). * major hemodynamic instability (defined as a continuous epinephrine or norepinephrine infusion at a flow rate \>1 μg/kg/min) * time from cardiac arrest to study inclusion \>300 min * moribund patient * child c cirrhosis of the liver * age \<18 years * pregnant or breastfeeding woman * correctional facility inmate * previous inclusion in another randomized clinical trial on cardiac arrest with day-90 neurological outcome as the primary endpoint * patient without health insurance * decision by the patient or next of kin to refuse the study
habit-ile in adults with chronic stroke (habit-ile stroke)

Conditions: Stroke

Summary: using a randomized controlled trial design, the possible changes induced by the intensive treatment program "hand-arm bimanual intensive therapy including lower extremities (habit-ile)" will be studied in functional, everyday life activities and neuroplastic assessment of adults with chronic stroke.

using a randomized controlled trial design, the possible changes in neuroimaging, motor function, motor learning and everyday life activities of adults with chronic stroke (\> 6 months) after participating of the intensive treatment programme "hand-arm bimanual intensive therapy including lower extremities" (habit-ile) will be studied. changes, scored by participants in case of questionnaires and by experts in the case of tests, will be observed comparing participants after their regular care/treatment and after receiving habit-ile. motor function, learning and daily life activities will be correlated with neuroplastic changes.

Eligibility criteria:
inclusion criteria: * hemiparetic patient with a chronic stroke (over 6 months of evolution) * age 40 to 90 years old inclusive * ability to follow instructions and complete testing according to the age. exclusion criteria: * alcohol/drug abuse * pregnancy * major cognitive impairment interfering with the study (severe aphasia, psychiatric conditions) * uncontrolled health issues (cardiac/renal failure) * contraindications to perform mri assessments (metal implants, etc.)
real zero fluoroscopy catheter ablation.

Conditions: Atrial Arrhythmia; Ventricular Arrythmia; Arrhythmia; Arrhythmias, Cardiac

Summary: a retrospective propensity matched study comparing: * real zero fluoroscopy catheter ablation * conventional fluoroscopy catheter ablation without 3d system * conventional fluoroscopy catheter ablation with 3d system

catheter ablation is a well-established treatment to treat patients with a wide scope of heart arrhythmias. the study is an investigator-initiated, retrospective analysis of prospectively collected data. the study population consists of patients with right-sided arrhythmias who underwent zero-fluoroscopy catheter ablation between the years 2016 and 2018 in 3 centers and a propensity score matched patients group of patients who: * underwent conventional fluoroscopy guided catheter ablation without 3d system (ensite/carto) support * underwent conventional fluoroscopy guided catheter ablation with 3d system (ensite/carto) support covariates for matching will be: * arrhythmia type * age of a patient * number of diagnostic catheters used during a procedure * type of a diagnostic catheter used during a procedure\]

Eligibility criteria:
inclusion criteria: * right atrial tachycardia * right atrial premature complexes * avnrt * right atrial avrt/wpw * right ventricle tachycardia / right ventricle premature complexes exclusion criteria: * left atrium arrhythmia * left ventricle arrhythmia

Keywords: atrial arrhythmia ventricular arrythmia ablation fluoroscopy
evaluating safety and efficacy in hepatitis c patients after pegintron pen treatment (study p04896)

Conditions: Chronic Hepatitis C

Summary: this is a non-interventional study designed to evaluate the efficacy and safety of combination study drugs in the treatment of participants diagnosed with chronic hepatitis c (chc). chc participants with confirmed positive hepatitis-c virus (hcv) rna in plasma, and who have not been previously treated with the pegylated interferon (pegintron) pen, were enrolled into study.

participants with positive genotype-1 hcv rna received 48 weeks of treatment of pegintron pen plus ribavirin and 24 weeks of follow-up. participants who were non-genotype-1 hcv rna positive received 24 weeks of treatment of pegintron pen plus ribavirin and 24 weeks of follow-up. participants were asked to complete a questionnaire to measure the satisfaction and the use of training materials of pegintron pen using a 1-5 score system provided in the questionnaire. the questionnaire was completed once at first follow-up visit. efficacy measurements for sustained viral response hcv rna was collected at week-24 of treatment and at week-24 of follow-up in positive non-genotype-1 hcv rna participants. efficacy measurements for sustained viral response hcv rna was collected at week-24 and at week-48 of treatment, and at week-24 of follow-up, for positive genotype-1 hcv rna participants.

Eligibility criteria:
inclusion criteria: * demonstrate willingness to participate in the study and comply with its procedures by signing a written informed consent. * equal to or greater than 18 years. * confirmed chronic hepatitis c with hepatitis c virus (hcv) rna positive in plasma. * no previous use of pegintron pen. exclusion criteria: * hypersensitivity to the active substance or to any interferon or to any of the excipients. * pregnant women. * women who are breastfeeding. * existence of or a history of severe psychiatric condition, particularly severe depression, suicidal ideation or suicide attempt. * a history of severe pre-existing cardiac disease, including unstable or uncontrolled cardiac disease in the previous six months. * severe debilitating medical condition, including patients with chronic renal failure or creatinine clearance \< 50 ml/minute. * auto immune hepatitis or a history of autoimmune disease. * severe hepatic dysfunction or decompensated cirrhosis of the liver. * pre-existing thyroid disease unless it can be controlled with conventional treatment. * epilepsy and/or compromised central nervous system (cns) function.

Keywords: chronic hepatitis c pegylated interferon pegintron pen ribavirin
effect of exercise intervention on various physiologic factors that change with increasing age

Conditions: Aging

Summary: this study randomized healthy sedentary people age 20-80 years to 16 weeks of supervised exercise versus no exercise. several end points were evaluated after 16 weeks including insulin sensitivity and muscle physiology.

healthy subjects performing \ 2 %. insulin sensitivity and muscle mitochondrial protein synthesis were studied.

Eligibility criteria:
healthy subjects performing \< 30 min exercise twice per week. age 20-90 years. willing to be randomized to exercise versus no exercise. willing to be studied in general clinical research center with studies including muscle biopsy.
respiratory and submental muscles activity during inspiration and expiration in obstructive sleep apnea syndrome

Conditions: Obstructive Sleep Apnea

Summary: in this study respiratory and submental muscle activities during during inspiratory and expiratory breathing maneuver at specific workloads will be assessed according to inspiratory and expiratory muscle strength of each obstructive sleep apnea syndrome (osas) patient's.

recurrent upper airway obstruction, apnea-hypopnea events, arousals and asphyxia during sleep increase the respiratory workload in patients with osas. this results in chronic overload of the inspiratory muscles -especially the diaphragm- and respiratory muscle fatigue in osas. when the literature was checked, there was no study assessing and comparing the activities of m. genioglossus, submental muscles (upper airways dilator muscles) and diaphragm during inspiration and expiration in a workload. differences in the activity of these muscles according to the type of respiratory maneuver will provide more appropriate respiratory muscle training in patients.

Eligibility criteria:
inclusion criteria: * between 35-70 years old * diagnosed with mild-moderate osas * clinically stabile exclusion criteria: * anatomical obstructive upper airway * occupations that lead to sleep deprivation or alterations in the sleep-wake cycle. * comorbidities such as chronic obstructive pulmonary disease, asthma, interstitial lung diseases, neuromuscular diseases and psychiatric diseases

Keywords: obstructive sleep apnea emg inspiratory muscles expiratory muscles
soft tissue integration of different abutment surfaces

Conditions: Edentulous Alveolar Ridge; Soft Tissue Healing

Summary: objective of the present study was to assess the peri-implant soft tissue profiles between argon plasma pre-treated (pt) and non-treated (npt) abutments by comparing clinical and histological parameters 2 months after abutment placement.

patients that need implant supported restoration were recruited for this study. at baseline a specific abutment was screwed at 20 n.two months following healing abutment placement clinical measurements were evaluated. endopoints of the study: histological outcomes at 2 using traditional histological staining (ematossilin/eosin) immunohistological outcomes at 2 using different stainings. postoperative complications. comparison between the histological outcomes and the preoperative clinical evaluation of the sites

Eligibility criteria:
inclusion criteria: 1. patient requiring implant supported restoration. 2. residual alveolar bone width of edentulous jaw of \> 8mm. 3. keratinized mucosa width of \>6mm 4. males and females between 18-80 years old 5. patients with healthy periodontal conditions (treated periodontitis, pi\<25%, bop\<25%) 6. patients that are willing to sign an informed consent and participate in a clinical study 7. generally fit and healthy and able to undergo oral surgical procedures under local anesthesia. 8. teeth at the surgical site which required removal were extracted a minimum of 12 weeks prior to sinus floor elevation exclusion criteria: 1. patients who smoke over 10 cigarettes/day 2. pregnancy (confirmed by verbal inquiry) 3. chronic systemic pathologies (e.g. diabetes) and neoplastic of the oro-facial district 4. 4. patients taking bisphosphonates 5. any sites where an implant already failed sites 6. untreated periodontitis 7. dental sites with acute infections 8. chronic inflammatory diseases of the oral cavity 9. autoimmune diseases (cortisone intake) 10. allergy declared to one or more medicaments to be used during treatment 11. alcoholics patients and/or drug addicts. 12. history or malignant tumours of the maxillary sinus 13. history of local radiation therapy
the role of dietary calcium for the treatment of osteopenia in girls with rett syndrome

Conditions: Rett Syndrome

Summary: randomized, placebo-controlled trial of oral calcium supplementation for osteopenia in girls and women with rett syndrome

objective: the investigators conducted a randomized, double-blind, placebo-controlled trial to determine the safety and efficacy of oral calcium supplementation for the treatment of bone mineral deficits in individuals with rett syndrome (rtt). methods: the investigators measured total body bone mineral content (bmc) and bone mineral density (bmd) by dual-energy x-ray absorptiometry and biomarkers of bone turnover by clinical laboratory techniques before and one year after oral calcium or placebo supplementation in 32 pre- and post-pubertal girls and young women with rtt. the calcium supplement was calculated to provide a twofold increase in the recommended dietary allowance of calcium for age.

Eligibility criteria:
inclusion criteria * clinical diagnosis of rett syndrome exclusion criteria * parathyroid disease * renal disease

Keywords: low bone mass
neuroglove pd study clinical

Conditions: Parkinson Disease

Summary: safety and feasibility of peripheral sensory stimulation of the hand in the treatment of parkinson's disease

this is a prospective, homebased, interventional clinical study in which 8 subjects will be enrolled. eight (8) subjects who suffer from parkinson's disease will receive treatment using the neuroglove. up to 8 subjects enrolled and complete study procedures. there will be a single cohort in the study consisting of the subjects with pd who will receive treatment with neuroglove.

Eligibility criteria:
inclusion criteria: 1. able to and willing to provide informed consent. legally authorized representatives (lars) will not be allowed to consent on behalf of the subject. 2. men and women ≥18 and \<85 years of age. 3. carry an active diagnosis of pd 4. suffer from pd symptoms that impact subject's daily activities and quality of life exclusion criteria: 5. physical limitations of the upper extremity (e.g., fracture, joint deformity, severe spasticity/contracture, wounds, skin breakdown, lymphedema, etc.) 6. lacks the ability to comprehend or follow instructions, or for any reason, in the opinion of the investigator, would be unlikely or unable to comply with study protocol requirements. 7. currently participating in another interventional clinical trial (observational clinical trial participation is allowed for study enrollment.)
a pilot study testing 1064nm q-switch laser versus glycolic acid peels for the treatment of melasma

Conditions: Melanosis

Summary: the purpose of this study is to find out the safety and effectiveness of 1064 q-switch laser therapy compared to glycolic acid chemical peels for the treatment of melasma.

participants in this study will be patients at the dermatology clinic who are clinically diagnosed with at least a 2x2 cm patch of melasma on each side of their face (forehead or cheek). starting at 2 weeks before treatment (week 2), both sides will be pretreated and primed with 4% hydroquinone with, if necessary, 2.5% hydrocortisone cream bid. on the treatment day (2-weeks) and 6-weeks one half of the subject's face will receive glycolic acid peels and the other half of the face will receive 1064nm q-switch laser. this study is a pilot study designed to determine feasibility of these procedures.

Eligibility criteria:
inclusion criteria: 1. subjects aged 18 years or older 2. subjects with at least a 2 x 2 cm patch of melasma on each side of the face (forehead or cheek) 3. subjects in general good health 4. subjects must be willing and able to understand and provide informed consent for the use of their tissue and communicate with the investigator 5. subjects must be willing to not apply other treatment options for melasma during the course of the study exclusion criteria: 1. subjects under 18 years of age 2. subjects who are pregnant and/or lactating 3. subjects who are unable to understand the protocol or to give informed consent 4. subjects diagnosed with mental illness 5. subjects who have concurrent active uncontrolled disease to facial area (i.e uncontrolled acne) 6. subjects who have had a chemical peel in the past 3 months 7. subjects who have used a prescribed retinoid in the past 3 months 8. subjects with a bleeding disorder 9. subjects with a history of abnormal wound healing 10. subjects with a history of abnormal scarring 11. subjects who report being allergic to glycolic acid