Kornimate/medical-research-clean huggingface dataset:
role of the ketogenic diet in women with pcos

Conditions: Polycystic Ovary Syndrome

Summary: for the fact of pcos symptoms could be improved with weight loss and improving insulin resistance, the investigators will do this study to evaluate the role of the ketogenic diet in overweight and obese women with pcos.

polycystic ovary syndrome (pcos) is one of the most common endocrinal abnormalities that affect females within the reproductive age, and are found in about 4% of women. pcos is commonly associated with symptoms of increased testosterone such as irregular or absent menstrual cycle, increased body hair, and infertility. pcos is also associated with other disorders such as obesity, insulin resistance, hyperinsulinemia, diabetes mellitus type 2, and dyslipidemia. until now, there is no known curative treatment for pcos. however, anti-diabetic medications can improve many metabolic disorders such as insulin resistance, and increased levels of serum testosterone and total cholesterol. in addition, regulation of diet with exercise could improve the insulin sensitivity. therefore, managements that aim to decrease the insulin level, improve the insulin resistance and decrease the body weight may be useful for improving symptoms of pcos. ketogenic diets are characterized by a reduction in carbohydrates (usually to less than 50 g/day) and a relative increase in the proportions of protein and fat. people following the keto diet gain 75% of their calories from fat, 20% from protein, and 5% from carbohydrates. previous studies have revealed that the ketogenic diet of low carbohydrate could decrease the body weight and improve the insulin resistance.

Eligibility criteria:
inclusion criteria: 1. age range between 16-35 years. 2. bmi ≥ 27. 3. normal renal function. 4. rotterdam criteria for the diagnosis of polycystic ovary syndrome: * oligo/anovulation * hyperandrogenism * polycystic ovaries on ultrasound. exclusion criteria: 1. age \ 35 years. 2. bmi \< 27. 3. pregnancy. 4. major medical disorders or other concurrent medical illnesses e.g. dm, other causes of androgen excess and hypercholesteremia 5. current or previous use of hormonal, anti-diabetic or anti-obesity drugs, or other drugs that affect hormone levels, carbohydrate metabolism or appetite.
adipose inflammation and diabetes (fab)

Conditions: Obese

Summary: the study investigates whether the addition of resolution molecules can inhibit inflammation and insulin resistance in human tissue taken from obese individuals, and whether the results of these studies correlate with patient-specific resolution phenotypes.


Eligibility criteria:
inclusion criteria: * bmi 30-40 kg/m2 * ptos (i.e. excess skin) \> 3 cm * patient underwent gastric bypass surgery \>2 years ago * patient has had a stable weight ≥6 months at the time of operation * patient does not smoke (min 6 weeks prior to surgery) exclusion criteria: * patients who do not understand spoken and written swedish * american society of anesthesiologists (asa) classification ≥ 3 * neurological, orthopedic or rheumatologic injury or illness affecting physical ability * preoperatively known hernia requiring surgical operation * severe mental illness
application of virtual reality in post-operative recovery of a pediatric scoliosis patient population

Conditions: Adolescent Idiopathic Scoliosis

Summary: the purpose of this study is to assess the effect of virtual reality on subjective post-operative pain, total inpatient narcotic administration, and mobilization with physical therapy in pediatric patients who have undergone surgical correction for idiopathic scoliosis.

all pediatric patients (ages 13-18) at connecticut children's medical center undergoing corrective scoliosis surgery for idiopathic scoliosis are eligible and will be approached for consent and inclusion into the study. this is a prospective pilot study, and all enrolled patients will receive a virtual reality (vr) intervention using a commercially available device manufactured by oculus. the vr software will simulate a low physical load environment, such as an underwater space exploration game. starting on postoperative day 1, the prospective cohort will undergo a 20-minute vr session 30 minutes prior to each physical therapy session. there will be two physical therapy sessions scheduled daily for the participant. outcome measures will be assessed before and after the vr session and after the physical therapy session. the following procedures will continue daily until the participant is cleared for hospital discharge. a retrospective chart review will also be performed on patients with idiopathic scoliosis who have undergone corrective surgery to serve as a historical control for the study. the retrospective arm of the study only includes patients who have not received a vr intervention.

Eligibility criteria:
inclusion criteria: * all pediatric patients (ages 13-18) at connecticut children's undergoing surgical correction for idiopathic scoliosis over a span of 12 months exclusion criteria: * history of seizures * cognitive developmental delay precluding participation in vr * head or neck surgery that does not allow a head-mounted display to be worn safely * chronic pain requiring the daily use of opioids for more than 2 weeks prior to the procedure * non-english speakers * side effects during screening * patients with vagal nerve stimulators, cardiac pacemakers, and/or cochlear implants that may receive interference from the vr device
prognostic factors of patients with covid-19

Conditions: SARS-CoV-2; Outcome, Fatal

Summary: the outbreak of coronavirus disease 2019 (covid-19) caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2) in china has been declared a public health emergency of international concern. despite lower mortality rate, sars-cov-2 has killed more people than sars and mers and the number keeps growing. epidemic studies have been well described clinical features of patients with covid-19, with the disease severity being an independent predictor of poor outcome. however, there is still no research investigating the prognostic factors of patients with covid-19.


Eligibility criteria:
inclusion criteria: * adult aged \>=18years old; * diagnosed with convid19. diagnostic criteria including: laboratory (rt-pcr) confirmed sars-cov-2 infection; ct of the lung conformed to the manifestation of viral pneumonia. * criteria for severe or critical ill conditions: respiratory rate \>=30/min; or rest spo2\<=93%; or pao2/fio2\<=300mmhg. exclusion criteria: * near-death state (expected survival time less than 24 hours); * malignant tumor; * pregnancy or puerperium women; * patients who refused to participant.
novel therapies for essential tremor

Conditions: Essential Tremor

Summary: this clinical research program is designed to evaluate medications as new treatments for essential tremor. essential tremor is a common condition with few available therapies.

each medication will be evaluated for effectiveness against tremor in a randomized, placebo-controlled, cross-over, double blind clinical research trial. tremor will be assessed with accepted rating scales and accelerometry

Eligibility criteria:
1. diagnosis of essential tremor. 2. tremor rating scale score 3 or one or both upper extremities 3. unsatisfactory response to primidone or to propanolol 4. not taking tremor-inducing drug 5. able to comply with visits
combining chinese medicine and nutrition to enhance weight loss after bariatric surgery

Conditions: Traditional Chinese Medicine Treatment; Weight Change

Summary: this study aims to investigate the effects of chinese herbal granule preparations on improving gastrointestinal symptoms in patients after bariatric surgery. it seeks to establish a novel treatment model that combines bariatric surgery with traditional chinese medicine, providing clinical practice with additional evidence-based medical support.


Eligibility criteria:
inclusion criteria: 1. bmi ≥ 27.5 kg/m²; 2. undergoing metabolic bariatric surgery; 3. traditional chinese medicine syndrome differentiation classified as spleen deficiency and excess dampness syndrome. exclusion criteria: 1. contraindications for metabolic bariatric surgery; 2. type 1 diabetes; 3. complicated by other significant systemic diseases, such as severe liver and kidney diseases, malignant tumors, psychiatric disorders, etc; 4. concurrent use of other medications or treatments that may affect body weight, such as metformin, semaglutide, endoscopic interventions, etc; 5. pregnant or lactating women.
randomized translational study to examine the effects of shared care in management of gestational diabetes

Conditions: Gestational Diabetes Mellitus

Summary: research question (s)/hypothesis: 1. . the effectiveness of the shared care management of gestational diabetes mellitus; 2. . the cost-effectiveness of the shared care management; 3. . its sustainability

method (s) tianjin three-tier antenatal care network established a universal screening program for gestational diabetes mellitus (gdm) in 1998 and up to 2008, the screening program had screened 115348 pregnant women. gdm will be defined as either fasting plasma glucose (pg) ≥5.1 mmol/l or 1-hour pg≥ 10.0 mmol/l or 2-hour pg≥ 8.5 mmol/l after 75 g glucose tolerance test. a total of 920 pregnant women who have gdm and agree to participate will be randomly assign to have the shared care (diet, physical activity and insulin if indicated) or the local usual antenatal care. the sample size has ≥80% power at a 5% type i error to detect the difference in the primary endpoint, birth weight ≥4000 gram and the secondary endpoint, pregnancy-induced hypertension. hyperglycemia and other clinical data in the two groups of women will be collected during the shared care or the usual care. logistic regression and cost-effectiveness analysis will be used in the data analysis. public health significance: the introduction of the proven management of gdm in tianjin antenatal care network will justify the universal screening for gdm and reduce the rate of macrosomic infants and reduce pregnancy-induced hypertension, and thus improve pregnancy outcomes of women with gdm. sustainability plan: just as the universal gdm screening in 1998, the shared care model will be introduced into the tianjin antenatal care network as part of the usual care routine after the proposed study. the success of the care model will also be publicized and expanded to suburban districts and rural counties of tianjin, possibly other parts of world where universal screening for gdm is a routine practice. acknowledgement this project is supported by a bridges grant from the international diabetes federation. bridges, an international diabetes federation project, is supported by an educational grant from lilly diabetes."

Eligibility criteria:
inclusion criteria: * all pregnant women who are diagnosed to have gdm. exclusion criteria: * diagnosis of overt diabetes during ogtt; * younger than 18 years of age; * non-singleton pregnancy; * maternal-foetal abo blood type incompatibility; * maternal diseases such as chronic hypertension,thyrotoxicosis, prepregnancy diabetes and use of long-term medications that may affect glucose metabolism.

Keywords: gestational diabetes mellitus intervention shared care pregnancy outcome macrosomia pregnancy-induced hypertension
effectiveness of narrow-band ultraviolet b combined with topical tacrolimus 0.03% in treatment of patients with vitiligo

Conditions: Vitiligo

Summary: the study will compare the effectiveness of combined treatment with nb-uvb and tacrolimus versus nb-uvb alone . patients will be treated for 6 months and followed up after 3 months .all types of vitiligo will be included except universal vitiligo.

study approval: the study will be submitted for approval by the scientific and ethical committees at faculty of medicine, south valley university, qena. an informed written consent will be obtained from all participants. study design: a randomized controlled trial. study population: the study will include patients who attend the outpatient clinic of dermatology, venereology and andrology, faculty of medicine, south valley university, with clinical diagnosis of vitiligo. patients with universal vitiligo, women who are pregnant or lactating at the time of recruitment, children ≤ 2 years old, patients with acute or chronic disease that might affect skin barrier function or patients with history of photosensitivity will be excluded. methods: * wash out period: ( 4 weeks) during this period, initial medical evaluation will be performed, social demographic data will be collected and patients will be enrolled after obtaining a written consent. * test period: (6 months) \*randomization: at the initial visit (visit 0), following the wash out period and before the start of treatment, patients will be randomly assigned to 2 treatment groups; group (a) : patients will receive nb-uvb sessions twice weekly for 6 months. initial dose will be 100 mj/cm2, the dose will be increased by 10% per session. group (b) : patients will receive nb-uvb sessions twice weekly for 6 months with the same dose plus topical application of tacrolimus 0.03% ointment twice dialy for the first month of treatment and once dialy for the rest 5 months of treatment. all patients will be evaluated before the start of treatment (visit 0) and at monthly intervals for 6 months.

Eligibility criteria:
inclusion criteria: * all patients with clinical diagnosis of vitiligo. exclusion criteria: * patients with universal vitiligo, women who are pregnant or lactating at the time of recruitment, children ≤ 2 years old, patients with acute or chronic disease that might affect skin barrier function or patients with history of photosensitivity.
promoting lactation education, access, and support efforts for preterm infants

Conditions: Breastfeeding

Summary: the purpose of this study is to determine whether a post-hospital discharge lactation support system increases preterm infant intake of mother's milk.

preterm infants have barriers to successful breastfeeding that include oral feeding immaturity and high nutritional needs. therefore, successful preterm infant breastfeeding requires increased counseling and equipment support compared to full-term infant breastfeeding. inpatient preterm infant care has responded to these barriers, with specialized preterm infant lactation support. unfortunately, for preterm infants, the onset of feeding maturity often coincides with hospital discharge and, therefore, inpatient, specialized lactation support ends just as the infant initiates nutritive feeding at the breast. therefore, the success of preterm infant breastfeeding relies on the home environment and the community pediatric caregivers. a program has been created to provide this specialized preterm infant/mother outpatient lactation support. the program includes in-home availability of a hospital-grade electric pump and an infant weigh scale and pediatric clinic-based lactation counseling support. fourteen pediatric practices are included in this study. seven practices were randomized to intervention and seven were randomized to be controls.

Eligibility criteria:
inclusion criteria: * any infant discharge to home from the medical university of south carolina neonatal services * born \<35 weeks' gestation * mother providing her milk and plans to continue providing her milk for at least 6 months * the infant's post-discharge pediatric clinic identified by mother as one involved in the study * the eligible twin will be the first twin discharged from the hospital or, if discharge occurs simultaneously, the infant identified in the hospital as "twin a" will be eligible. exclusion criteria: * infants with major congenital anomalies * infants with anomalies affecting oral intake * infants receiving tube feeds at hospital discharge * infants receiving parenteral nutrition at hospital discharge * triplet or greater pregnancies * twin of the one enrolled twin will not be eligible.
neuroplasticity-oriented cognitive intervention in early onset and first admission schizophrenia

Conditions: Psychosis

Summary: the purpose of this study is to reveal the specific effects of computer-aided cognitive training on course and rehabilitation in early onset schizophrenia

impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease. we examine the beneficial effect of computer-aided training program on course and rehabilitation of young psychotic patients with early onset psychosis. in addition we develop predictors for the course of disorder from neuroimaging data.

Eligibility criteria:
inclusion criteria: * early onset psychosis exclusion criteria: * chronicity * insufficient german skills

Keywords: brain oscillations cognitive performance
revascularization pretreated with fingolimod in acute stroke

Conditions: Stroke

Summary: acute ischemic stroke (ais) is a common type of stroke in the elderly. timely blood flow recovery can effectively improve the long-term prognosis of patients. according to five large-scale multicenter randomized controlled trials (mr clean, swift-prime, revascat, escape and extend-ia) in recent years, the effect of endovascular therapy (evt) for acute anterior circulation occlusion of great vessels is significantly better than that of drug therapy alone. therefore, for patients who meet the "chinese guidelines for the diagnosis and treatment of acute ischemic stroke" (2018 edition), the effect of evt is better than that of drug therapy alone, intravenous thrombolysis within 4.5 hours and endovascular mechanical thrombectomy within 6 hours can effectively relieve the clinical symptoms and reduce the mortality of ais. however, due to the narrow application time window of intravenous thrombolysis and mechanical thrombectomy, although the thrombectomy time window of some eligible patients was relaxed to 24 hours after dawn and defuse3 and other related studies, the reperfusion injury after the blocked cerebral artery recanalization has brought huge obstacles to clinical application. therefore, how to improve the prognosis of patients with endovascular therapy has become a hot research direction. fingomod is a kind of sphingosine analogues acting on sphingosine-1-phosphate (sipr). after phosphorylation in the body, fingomod combines with lymphocyte sip receptor, changes lymphocyte migration route, prevents it from entering the area outside the lymphoid tissue, so as to avoid its infiltration into the central nervous system and achieve immunosuppression. currently, it is the first-line disease modifying oral drug for multiple sclerosis. fingolmod shows neuroprotective effects on many central nervous system diseases including cerebral ischemia. fingomod not only reduced the number of lymphocytes invading the brain, but also decreased the number of lymphocytes in the microcirculation system


Eligibility criteria:
inclusion criteria: * the patient was over 18 years old; * the nihss score was \ 5; * cta / mra / dsa confirmed occlusion of m1 segment of internal carotid artery or middle cerebral artery, and aspect score ≥ 6; * ctp or mri showed mismatch (ischemic core volume \ 1.2 * normal to random time within 24 hours * written informed consent signed by patients or their families exclusion criteria: * standard contraindications to alteplase or mechanical thrombectomy * cerebral hemorrhage confirmed by imaging * cardiovascular diseases (such as bradycardia, etc.) * systolic blood pressure \> 185mmhg or diastolic blood pressure \> 110mmhg, and oral antihypertensive drugs can not be controlled * pregnant or lactating women
nicotine and tobacco message framing to change smoking behavior in diverse groups of young adult smokers

Conditions: Tobacco-Related Carcinoma

Summary: this clinical trial evaluates the effect of message framing on smoking behaviors among lesbian, gay, bisexual, transgender, queer (lgbtq+) young adults who use nicotine and/or tobacco. tobacco regulation has contributed to a steady decline in tobacco products designed to be smoked (combustible), but there has been an increase in the use of new tobacco products, such as electronic nicotine delivery systems (ends). the use of more than one tobacco product (polytobacco) is high in lgbtq+ populations. both lgbtq+ people and people who engage in polytobacco use are less likely to view tobacco as harmful, which may reinforce tobacco use. message framing includes culturally targeted messages to communicate the absolute risks (ar) and relative risks (rr) of polytobacco use. using message framing may increase quit rates or change smoking behaviors in lgbtq+ young adults who use nicotine and/or tobacco products.

primary objectives: i. assess the feasibility of delivering mobile multimedia messaging (mms) anti-tobacco messages developed in the k99 to lgbt young adults via texting. ii. estimate effect sizes of exposure to anti-tobacco messages on risk perceptions and tobacco use over time. outline: participants are randomized to 1 of 3 arms. arm i: participants receive ar anti-polytobacco mms messages 3 times a week (tiw) and a check-in text message once a week (qw) for a total of 6 weeks. arm ii: participants receive rr anti-polytobacco mms messages tiw and a check-in text message qw for a total of 6 weeks. arm iii: participants receive control mms messages on health risks of ultraviolet (uv)/sun exposure tiw and a check-in text message qw for a total of 6 weeks. all participants also receive smoking cessation resources via email during follow up. after completion of study intervention, participants are followed up at 6 and 12 weeks.

Eligibility criteria:
inclusion criteria: * 18-35 years old * self-identify as lgbtq+ * able to speak english fluently * an ever user of ends and combustible tobacco who currently use ends, combustible cigarettes, or both ends and combustible cigarettes * currently reside in the united states (us) * have a mobile phone through a u.s. carrier with mms messaging and can send and receive text messages for study participation * access to the internet with zoom capabilities exclusion criteria: * have a landline or voice over internet protocol (voip) phone number

Keywords: sexual and gender minorities health communication tobacco products cigarettes electronic nicotine delivery systems e-cigarettes young adult text messaging
tempus pro monitor registry

Conditions: Sudden Cardiac Arrest; Emergency Care

Summary: a multicenter, prospective and retrospective, observational, post market study.

this observational study is to collect real-world data on the safety and performance of the tempus pro device, its accessories and the intellispace corsium telemedicine software device when used according to its intended purpose and the instructions for use, when used for patient monitoring.

Eligibility criteria:
inclusion criteria: patients monitored by using tempus pro during pre-hospital care (ambulance transportation) one or more 12-lead ecg recorded use of 3 or more of the following sensors to measure vital signs * nibp (non-invasive blood pressure) * hr (heart rate) * spo2 (oxygen saturation) * pvi (pleth variability index) * spco (carboxyhemoglobin) * spoc (oxygen content) * sphb (total hemoglobin) * spmet (methemoglobin saturation) * etco2 (end-tidal carbon dioxide) exclusion criteria: * none defined

Keywords: tempus pro intellispace corsium