Kornimate/medical-research-clean huggingface dataset:
oral care as a preventive measure of vap; miswak versus chlorhexidine and toothbrush.

Conditions: Ventilator Associated Pneumonia

Summary: dental plaque score calculation and swabs of oropharynx and teeth were collected on admission. for group i, miswak stick was used 4 hourly for oral care. for group ii, 0.12% chlorhexidine/ toothbrush were used 4 hourly

the selected patients were randomized into 2 groups by the conventional method of randomization. for each patient the following parameters were collected: patient data; age, gender; history of smoking; chronic health problems; history of drugs as steroids, chemotherapy, current antimicrobial therapy; and the primary cause of hospital and icu admission and mechanical ventilation. clinical examination included assessment of disease severity on admission by acute physiology and chronic health evaluation (apache ii) scoring system, oral and dental examination, and dental plaque score calculation. oropharyngeal and dental swabs were collected on admission. the preventative vap bundle was applied to all patients in both groups. for group i, miswak was used for oral care, patient's teeth were brushed every 4 hours using a miswak stick after scraping of half an inch bark from the stick end then miswak tip was washed and compressed to make it brush like. both buccal and lingual surfaces of teeth were brushed using mechanical method for plaque removal (in direction away from gingival margin,). the patient's tongue was brushed when possible and lip moisturizer was applied as needed. the brush like end of sewak stick was cut and replaced daily. for group ii, the patient's teeth were brushed every 4 hours using a soft toothbrush with 0.12% chlorhexidine solution. both buccal and lingual surfaces of teeth were brushed using mechanical method for plaque removal (in direction away from gingival margin,). the patient's tongue was brushed when possible and lip moisturizer was applied as needed. the toothbrush was boiled for one minute every day. patients in both groups were monitored for the efficacy of oral care in term of plaque score and halitosis. colonization of trachea, oph, and dental plaque by potential respiratory pathogens (prps) as staphylococcus aureus, pseudomonas, klebsiella, proteus, acinetobacter and e. coli species was identified by culturing of oph swab, dental swab and endotracheal tube (ett) aspirate on inclusion into the study and every 4 days thereafter till icu discharge, 3 weeks of icu stay, or death. secondary endpoints included time to vap and its incidence, duration of mv, icu discharge, and mortality rate. vap was diagnosed when patient developed; new and/or progressive infiltrates in chest radiograph plus two or more of the following; leucocytosis ≥ 12000/mm3 or leucopenia ≤ 4000c/mm3, fever \> 38oc or hypothermia \< 36oc, or mucopurulent secretion as evident by gross inspection. the clinically diagnosed vap was confirmed by quantitative endotracheal aspirate at a cut off value ≥105 colony forming unit (cfu) /ml.

Eligibility criteria:
inclusion criteria: * mechanically ventilated exclusion criteria: * none

Keywords: vap oral care chlorhexidine miswak (sewak)
measuring signatures in the fluid surrounding the spinal cord in patients who have problems with intrathecal drug delivery

Conditions: Cerebral Palsy; Multiple Sclerosis; Traumatic Brain Injury; Spinal Cord Injury

Summary: the purpose of this study is to record signatures from the fluid surrounding the spinal cord from people who have an implanted drug infusion system.

the purpose of this feasibility study is to record cerebrospinal fluid (csf) signatures from subjects who have an implanted drug infusion system and who undergo clinical tests designed to troubleshoot possible catheter-related problems as part of their normal standard of care. signatures will be correlated with physician-determined catheter status.

Eligibility criteria:
inclusion criteria: * be at least 12 years of age * have an implanted medtronic drug infusion system for chronic intrathecal administration of drugs * report decreased therapeutic benefit, or show visible signs and/or symptoms of decreased therapeutic benefit * agree to undergo clinical tests designed to troubleshoot catheter-related problems or failure as a part of their normal standard of care * agree to provide signed informed consent. exclusion criteria: * are currently enrolled or plan to enroll in another investigational drug or device trial * have participated in an investigational drug or device study within 30 days of the in-clinic visit * whose health status would, in the opinion of the clinical investigator, be jeopardized by participation in the study

Keywords: feasibility synchromed ii intrathecal catheter baclofen
physiologic elasticity changes during pregnancy and after labor.

Conditions: Vaginal Prolapse

Summary: female pregnant patients in their 2nd trimester will be evaluated for vaginal elasticity using vaginal tactile imaging in addition to elasticity evaluation during the 3rd trimester and 6 weeks postpartum.

female pregnant patients in their 2nd trimester will be evaluated for vaginal elasticity using vaginal tactile imaging. vaginal elasticity will also be evaluated during the 3rd trimester and 6 weeks postpartum. patients will be recruited and sign a consent form. assessment of vaginal elasticity via vaginal tactile imaging will be performed at 3 different points: * during the 2nd trimester. * during the 3rd trimester. * 6 weeks postpartum. every patient will serve as her own control. demographic, gynecologic and obstetric history will be obtained from patients' electronic files.

Eligibility criteria:
inclusion criteria: * pregnant patients in their 2nd trimester. exclusion criteria: * pregnant patients presenting after their 2nd trimester.
expanded access to rovalpituzumab tesirine

Conditions: Small Cell Lung Cancer

Summary: this is an expanded access program (eap) for eligible participants. this program is designed to provide access to rovalpituzumab tesirine prior to approval by the local regulatory agency. availability will depend on territory eligibility. participating sites will be added as they apply for and are approved for the eap. a medical doctor must decide whether the potential benefit outweighs the risk of receiving an investigational therapy based on the individual patient's medical history and program eligibility criteria.


Eligibility criteria:
inclusion criteria: * the participant must not be eligible for a rovalpituzumab tesirine clinical trial. * pediatric participants may be evaluated on a case by case basis. exclusion criteria: * none.

Keywords: expanded access, pre-approval access, compassionate use, special access program, named patient basis, special access scheme
choice of material for above-knee femoro-popliteal bypass prosthetic graft (popup)

Conditions: Intermittent Claudication; Critical Limb Ischemia

Summary: this trial was designed to challenge the wide held view that polytetrafluoroethylene (ptfe) performs better than dacron for above knee femoropopliteal bypass.

objective: to investigate whether patency rates of 6 mm gelatine coated, knitted, double velour polyester prostheses are equal to the 6 mm thinwalled eptfe prostheses as above-knee femoro-popliteal bypass graft

Eligibility criteria:
inclusion criteria: * all patients who require revascularisation of the lower extremity suitable for above-knee femoro-popliteal bypass surgery. exclusion criteria: * pregnancy * no consent to participate in the study * previous enrollment in the study * follow-up is not possible

Keywords: lower extremity bypass surgery femoro-popliteal bypass dacron material ptfe material
tonus, stiffness and elasticity of hand and wrist muscles in smartphone addiction

Conditions: Muscle Biomechanics; Smartphone Addisction

Summary: the aim of this study was to investigate the tonus, stiffness and elasticity of the hand and wrist muscles in intensive smartphone use.

consent was obtained from the students with the 'informed voluntary consent form' and the sociodemographic data of the students were recorded on the previously prepared descriptive data form. the students were asked to fill out the smartphone addiction scale-short form. before starting the clinical evaluation, anamnesis was taken from the students and their general health status, phone usage time (minutes) and exclusion criteria were questioned. myotone evaluations of the tenar region, flexor carpi radialis, flexor carpi ulnaris, extensor digitorum, extensor carpi radialis and extensor carpi ulnaris muscles were performed. then, the standard grip strength of the dominant and non-dominant side hand was evaluated with saehan hand dynamometer and the lateral grip strength of the thumb was evaluated with saehan pinchmeter.

Eligibility criteria:
inclusion criteria: * to study at bandirma onyedi eylül university * students between the ages of 18-30 years, whose voluntary consent was obtained and who use smartphones exclusion criteria: * individuals with musculoskeletal system problems such as fractures of the hand, fingers and upper extremities, rheumatoid disease with evidence of systemic, specific pathological conditions * individuals who have undergone any surgical operation related to hand, finger and upper extremity problems * individuals who have received hand, finger and upper extremity related physiotherapy and rehabilitation services in less than 6 months * individuals with diagnosed psychiatric illness.

Keywords: smartphone tonus stiffness elasticity
radiofrequency in onychomycosis

Conditions: Onychomycosis

Summary: onychomycosis is the most common nail disease, representing more than 50% of all onychopathies.

treatments with antifungals may not be successful due to several factors, including the long time required to apply topical medications, the side effects of systemic drugs, and the application of insufficient medication to the target area. non-ablative radiofrequency devices can be used to treat onychomycosis without harming the nail matrix cells.

Eligibility criteria:
inclusion criteria: * onychomycosis patients exclusion criteria: patients with excessive manual work
adjuvant zoledronic acid in high risk giant cell tumour of bone (gct)

Conditions: Giant Cell Tumor of Bone; Osteoclastoma

Summary: this is a multicenter, randomised phase ii trial in patients with high risk gct. primary objective: * determine if adjuvant zoledronic acid improves the 2 years recurrence rate of 'high risk' gct as compared to standard care secondary objectives: * determine the relapse free survival * evaluate the usefulness of bone remodelling markers in diagnosing and monitoring gct

gct is a potentially malignant tumour that presents with a locally destructive osteolytic lesion. the high risk gct are characterized by a high recurrence rate around the 40-45%. zoledronic acid is a potent inhibitor of osteolysis and is capable of inducing osteoclast and stromal cell apoptosis, which makes it an attractive adjuvant treatment in 'high risk' gct in order to improve clinical outcomes and reduce the recurrence rate.

Eligibility criteria:
inclusion criteria: * signed written informed consent * male or female \> 18 years of age * histologically proven gct treated with surgery * high risk gct defined as minimal one or more of the following: * recurrent gct * gct located in the pelvis, sacrum, spine, distal ulna or growth in soft tissue * gct grade iii * pathological fracture in gct * absence of local adjuvant therapy (cryosurgery or phenol instillation) * neutrophils \> 1.5x109/l, platelets \> 100x109/l, and hb \> 6 mmol/l * bilirubin level \< 1.5 x uln * asat and alat \< 2.5 x uln * adequate renal function as defined by: serum creatinine clearance \> 60 cc/min * expected adequacy of follow-up exclusion criteria: * unresectable or metastatic gct and grade iv gct * prior bisphosphonate usage, except preoperative treatment with zoledronic acid up to 3 months before surgery * other previous malignancy within 5 years, with exception of a history of a previous basal cell carcinoma of the skin or pre-invasive carcinoma of the cervix * known hypersensitivity reaction to any of the components of the treatment * pregnancy or lactating * medical or psychological condition which in the opinion of the investigator would not permit the patient to complete the study or sign meaningful informed consent

Keywords: gct bisfosfonates
interest of non invasive ventilation versus oxygen during the intial managment of infant with bronchiolitis

Conditions: Bronchiolitis; Respiratory Distress

Summary: the purpose of the study is to evaluate, in a prospective way, the clinical, the manometric an gazometric benefit of non-invasive ventilation (vni), (infantflow \[eme, brighton, england\]) during bronchiolitis of the infant compared to a conventional managment.

1. experimental plan: the infants (0 to 6 month) admitted in pediatric intesive care unit for respiratory distress with bronchiolitis but not requiring mechanical ventilation are randomized in two groups: group "a" is treated with a non-invasive ventilation device(infantflow) during 6 hours, group "b" is treated conventionally by inhalation of a air/o2 mixture during 6 hours. 2. outcome: primary outcome: clinical score of respiratory distress at h0 and h6. secondary outcome: respiratory and cardiac frequency, average blood pressure. manometric: variation of esophageal pressure at h0, h6. gasometric: minimal fio2 necessary to reach an oxygen saturation between 94 and 98%, transcutaneus pco2, pao2/fio2 3. analyze results: intention to treat analysis after having checked the randomization by comparing clinical gravity in the two arms (clinical score). 4. calendar of the study: october 2006 at april 2008 5. follow-up of the patients: the study proceeds during the hospitalization of the infants during 6 hours and will not impose any specific follow-up.

Eligibility criteria:
inclusion criteria: * infant from 0 to 6 months admitted in the picu * clinical diagnosis: bronchiolitis * signs of respiratory distress evaluated with a clinical score of respiratory distress \> 4 exclusion criteria: * cardiopathy, cystic fibrosis or a neuromuscular desease * need for mechanical ventilation

Keywords: bronchiolitis esophageal pressure mesurement clinical score citical care infant
role of transrectal-ultrasound in evaluation of azoospermia

Conditions: Infertility Due to Azoospermia

Summary: azoospermia is a word meaning to ejaculates with no spermatozoa without a definite underlying cause .1% of men has azoospermia, representing nearly 10 to 15% of all infertile men. the azoospermia is a major concern in our community. there is no actual epidemiological studies to estimate the actual numbers in egypt. azoospermia has several classifications, pre-testicular, testicular \& post-testicular cause .the semen analysis is the main investigation done for these patient .the treatment methods range from hormonal therapy to surgery or icsi . the imaging modalities has developed greatly in the last 3 decades. that it became in several setting as a bedside test or investigation. the main modalities used in azoospermia are scrotal ultrasound, trus and mri. the first trus was introduced 1957.


Eligibility criteria:
inclusion criteria: * • adult patients with azoospermia as identified by semen analysis. * age from 18 years to more exclusion criteria: * • history of operative intervention in the lower urinary tract.
jin-shui huan-xian granule in the treatment of ipf

Conditions: Idiopathic Pulmonary Fibrosis

Summary: this study is to evaluate the efficacy and safety of jin-shui huan-xian granule for idiopathic pulmonary fibrosis (ipf), establish the treatment scheme, and obtain the high quality clinical evidences.

idiopathic pulmonary fibrosis (ipf) is a chronic, progressive and ultimately fatal interstitial lung disease. with worsened dyspnea and an increasing loss of pulmonary function, ipf patients will have very poor quality of life. it has also brought an increasing social-economic burden. researches show that pirfenidone and nintedanib could be effective to ipf, which were also recommended by the guideline. however, the application has been limited by side effects and high prices. it is urgent to develop other effective treatments and strategies to manage ipf. the investigators' previous studies shown that jin-shui huan-xian granule could be effective to ipf. this is a multicerter, randomized, double-blind, placebo-controlled trial to assess the efficacy of jin-shui huan-xian granule in reducinig the acute exacerbations, improving exercise capacity, and delaying the disease progression for ipf. after a 2-week wash-out period, 312 patients will be randomly assigned into treatment or control group for 52-week treatment. the primary outcomes are frequencies of acute exacerbation, 6-minute walking test, and percentage of patients with progression-free survival. the secondary outcomes include pulmonary function, all-cause mortality, clinical symptoms, dyspnea score, and quality of life. safety will also be evaluated.

Eligibility criteria:
inclusion criteria: * a confirmed diagnosis stable ipf. * age ranges from 40 years to 85 years. * tcm syndrome differentiation meets criteria of pattern of lung qi deficiency, yin deficiency and inter heat, and lung-kidney qi deficiency. * without participanting in any other trial. * with signed informed consent. exclusion criteria: * pregnant, nursing or may become pregnant women. * patients with unconscious, dementia or mental disorders. * patients with severe cardiac dysfunction. * patients with severe liver and kidney diseases. * patients with asthma, bronchiectasis, active pulmonary tuberculosis, pulmonary embolism, chronic obstructive pulmonary disease, chronic respiratory failure or other severe respiratory diseases. * patients with tumor after resection, radiotherapy or chemotherapy in the past 5 years. * patients with severe neuromuscular disorders, severe arthritis or severe peripheral vascular diseases. * patients with long-term bedridden. * patients who are allergic to any of the treatment drugs.

Keywords: idiopathic pulmonary fibrosis traditional chinese medicine randomized controlled trial
primary angle closure glaucoma and aqueous dynamics

Conditions: Primary Angle Closure

Summary: the aim of the study is to determine which is the best treatment for people with cataract and primary angle closure (pac).in pac, apposition of the iris tissue to the drainage channels (trabecular meshwork-tm) of the eye results in damage and formation of adherences between these structures (peripheral anterior synaechiae-pas) causing a mechanical obstruction of the aqueous outflow via the tm. it is thought that cataract surgery combined with mechanical separation of the iris from the tm with the breakage of pas(we call this separation 'goniosynechialysis') would make the pressure even lower as it would cause the drain to open to a greater extent than cataract surgery alone. this technique is not new, and the results have been very encouraging. comparing this technique to cataract surgery alone however, has not been done and this is exactly what we would like to do in order to help us decide what is the best treatment. in summary, the investigators propose that cataract surgery with goniosynechialysis would lower intraocular pressure to a greater extent than cataract surgery alone in patients with significant pas.


Eligibility criteria:
inclusion criteria: * age ≥ 21 years. * diagnosis of pac or pacg. pacg is defined as glaucomatous optic neuropathy in the opinion of a fellowship-trained glaucoma specialist, together with an iop \> 21mmhg on at least one occasion, and reproducible visual field defect (using the 24-2 test pattern on a humphrey field analyser). pac has all the above characteristics except for the visual field defect. * more than 90 degrees of pas (not necessarily contiguous). * lens opacity deemed sufficient to be causing decreased vision in the opinion of the supervising consultant (ksl). * ability to give informed consent. exclusion criteria: * previous intraocular surgery or keratorefractive surgery. * previous eye trauma resulting in documented damage to the drainage angle (such as angle recession). * history of uveitis. * for patients on warfarin, inr \>3.0 on day of surgery. * anterior segment neovascularisation. * chronic use of topical or systemic steroids.

Keywords: primary angle closure glaucoma phacoemulsification goniosynechialysis outflow facility
recovery profiles in patients with sars-cov-2 outcomes undergoing rehabilitation

Conditions: Covid19_rehabilitation

Summary: covid19 patients survivors, after discharge from hospital show reduced lung function and reduced ability to exercise. furthermore, mental health problems including stress, anxiety and depression and a low quality of life were observed. the prospective observational study involves covid19 patients who have needed rehabilitation at the university hospital of ferrara. patients receive comprehensive rehabilitation based on their specific needs in both acute and subacute rehabilitation. at the end of hospital rehabilitation, patients are offered a program to be carried out at home for both physical and psychological problems. a range of demographic and clinical data will be collected. patients will also undergo a battery of functional, cognitive and psychological tests at 12, 26 and 52 weeks from the infection onset. moreover, a specific assessement (both clinical and instrumental) on the pain symptom experienced, where present, will be done.


Eligibility criteria:
inclusion criteria: * diagnosis of covid19 (who criteria); * indication for respiratory and / or neuromotor rehabilitation treatment exclusion criteria: * cognitive or communication impairment precluding informed consent * severe medical conditions * pregnancy

Keywords: covid19 rehabilitation mindfulness functional recovery psychological well-being pain post covid syndrome
the use of an age-linked app for parents during and after a nicu stay

Conditions: Premature Birth

Summary: the main purpose of the neonatal intensive care unit (nicu) is to optimize the development of the newborn. preterm children are at greater risk for developmental disorders. on the one hand, this is due to cerebral complications inherent to the prematurity, on the other hand it is related to the very early and therefore vulnerable stage of brain development at the time of the premature birth. the development of the child is also the result of a constant interaction between the infant and its environment, primarily the primary caregiver (i.e. the parents). a premature birth can cause great stress to parents, and there are several obstacles that can make it difficult to handle their child. therefore, we have developed a web application that supports parents until their child reaches the age of two. by keeping them informed, we hope to make them more confident in their role as parents, and thus facilitate the parent-child interaction. in order to determine whether this form of support has an additional effect on the development of the premature child, we compare two groups of premature infants and a group of non-premature infants.


Eligibility criteria:
inclusion criteria: * premature birth (\< 32 weeks) exclusion criteria: * the lack of internet access or a personal email account * little or no knowledge of dutch in both parents * children with a congenital disease

Keywords: prematurity psychomotor development parent empowerment e-health parental support post discharge follow-up