Kornimate/medical-research-clean huggingface dataset:
social and financial incentives to increase physical activity among overweight and obese veterans

Conditions: Physical Activity

Summary: in this randomized, controlled trial the investigators will compare the use of social and financial incentive-based interventions to increase physical activity among overweight and obese veterans during a 12-week intervention with 8 weeks of follow-up.

in this 3-arm randomized trial, the investigators will compare the effectiveness of a social incentive-based gamification intervention with and without loss-framed financial incentives to increase physical activity relative to a control among overweight and obese adults veterans. all veterans will use a fitbit wearable device to establish a baseline step count, select a step goal increase of 33% to 50% above baseline and then participate in a 12-week intervention and 8-week follow-up period. the two intervention arms will be entered into a game with points and levels designed using insights from behavioral economics. they will be asked to select a social support partner who will receive weekly updates on their progress in the game. veterans in one arm will also receive loss-framed financial incentives allocated to an account each week during the intervention and financial incentives taken away each day the step goal was not achieved.

Eligibility criteria:
inclusion criteria: * veterans * body mass index of 25 or greater * access to smartphone or tablet to sync wearable device data * interest in participating in a 20-week physical activity program exclusion criteria: * already participating in a physical activity research study * unable to provide informed consent * unsafe or infeasible to participate * no access to smartphone or table to sync wearable device data

Keywords: physical activity incentive wearable device gamification
cross-sex hormone therapy and neuronal plasticity

Conditions: Gender Dysphoria

Summary: transgender women (male-to-female) were invited to participate in this study to test the impact of cross-sex hormone therapy (csht) in the brain. neuroimaging and cognitive assessment were performed in different time-points to compare the impact of csht in the brain.

sex hormones are known to exert several effect on the brain white matter, cerebral cortex, functional connectivity and neurotransmission. furthermore, in transgender people, csht is know to induce anatomical and functional changes in the brain. however, only a few studies have already been conducted to investigate the effects of sex hormones on the brain accounting for the interference of endogenous gonadal hormones. also, there is a lack of knowledge about the importance of csht after gender affirming surgery (gas) regarding induced hypogonadism that follows this surgical procedure. therefore, neuroimaging studies designed to isolate the effect of endogenous gonadal hormones in people with gd urge to be developed. to fulfil this purpose, transgender women that have already performed gas and/or were under gonadotrophin release hormone analogues treatment (in order to induce hypogonadism similar to gas) were invited to interrupt csht for at least 30 days to promote sex hormones washout. at the end of the washout, participants performed magnetic resonance imaging, laboratorial analyses for sex hormones and neuro-cognitive assessment. after this first time-point, participants received a new prescription for csht containing estradiol (without progesterone) to be used continuously for 60 days, when the same assessments from the end of washout were repeated 60 days after csht to compare brain and cognitive longitudinal changes. at all the time-points, variations in depression scores and anxiety levels were assessed with specific scales.

Eligibility criteria:
inclusion criteria: * transgender women * age 18 to 60 years old. exclusion criteria: * use of psychostimulant drugs * use of antidepressive, mood stabiliser, anti-psychotic, benzodiazepines, anti-convulsivants, anorexigenic * endocrinological disease (other than diabetes) * arterial hypertensive disease of diabetes mellitus out of control target * neurological disease, including stroke or recent cranial trauma with loss or consciousness * hiv with low cd4 or high viral charge or symptomatic aids * neoplasia

Keywords: estradiol; brain glutamate spectroscopy hypogonadism
technology assisted collaborative care intervention to improve patient-centered outcomes in dialysis patients

Conditions: Chronic Kidney Disease Requiring Hemodialysis

Summary: the goal of this study is to learn if a collaborative care intervention of pharmaco-therapy and/or cognitive behavioral therapy (cbt), delivered in a real-world setting, improves symptoms of pain, fatigue and/or depression.

the goal of this study is to conduct a hybrid type ii effectiveness-implementation, cluster randomized trial of tāccare 2.0 facilitated by dialysis staff in a real-world setting. this is a multi-center, dialysis-clinic level cluster randomized trial of 424 patients from 36 dialysis clinics comparing taccare 2.0 facilitated by dialysis staff versus usual care. patients' dialysis clinic will be placed randomly into one of two study groups: the technology assisted stepped collaborative care intervention group or the usual care group. the intervention will target three of the most debilitating end state kidney disease (eskd) related symptoms- fatigue, pain and depression. a stepped collaborative care approach for pharmaco and/or cbt allows for shared decision-making and individualization of treatment according to a patient's clinical status, preferences and treatment response. the tāccare 2.0 intervention will build on successful design elements of the original intervention, enhance depression management strategies and increase durability of effect by incorporating monthly longitudinal telemedicine-delivered booster sessions to complete a total 12-month intervention. additionally, using a collaborative care approach, the patients' symptom management will be integrated with their dialysis treatment, thus increasing patient acceptability and adherence.

Eligibility criteria:
eligibility criteria: 1. age 18 years or older; 2. undergoing thrice-weekly maintenance hemodialysis (hd) for \> 3 months; 3. english or spanish speaking; 4. able to provide informed consent ineligibility criteria: 1. active thought disorder, delusions or active suicidal ideation 2. active substance abuse 3. enrolled in hospice or life expectancy \< 6 months (based on clinician's judgement) 4. too ill or cognitively impaired to participate based on renal provider's judgement 5. living kidney transplant scheduled in \<3 months 6. undergoing active cancer treatment. 7. enrolled in another research study 8. plan to transition to home dialysis within 3 months 9. plan to move to another dialysis facility within 3 months

Keywords: chronic kidney disease hemodialysis pain depression fatigue
comparation of class combined with phacoemulsification and class alone in the treatment of primary open angle glaucoma

Conditions: Glaucoma, Open-Angle

Summary: to compare the effect of intraocular pressure control and the incidence of peripheral anterior synechia between class combined with phacoemulsification and class alone in the treatment of primary open-angle glaucoma

group a: co2 laser-assisted sclerectomy surgery combined with phacoemulsification; group b: simple co2 laser-assisted sclerectomy surgery. the patients were followed up for 1 year. the incidence of peripheral anterior synechia and intraocular pressure changes at 1 day, 1 week, 1 month, 2 months, 3 months, 6 months and 12 months were observed and compared between the two groups.

Eligibility criteria:
inclusion criteria: * primary open-angle glaucoma patients with cataract in our ophthalmic center; * topical use of hypotensive drugs in the treatment of poor or intolerable intraocular pressure control; * the patients were aged from 50 to 80 years old, regardless of gender; * class operation and phacoemulsification were performed; * patients are able and willing to comply with the research guidance and may complete all visits required by the research; * informed consent has been signed. exclusion criteria: * allergic to any perioperative medication in this study; * history of ocular trauma; * any previous intraocular surgery; * angle of the chamber was narrow by angle microscopy (schaffer grade iii and below); * patients diagnosed as secondary glaucoma; * optic atrophy caused by other reasons; * the serious complications such as posterior capsule rupture and choroidal hemorrhage occurred during the operation; * serious complications of eyes occurred after operation; * the patient's history indicated that he had severe dysfunction of heart, lung, liver and kidney; * women in pregnancy, lactation or planned pregnancy; * the researchers believe that the patient's condition may put the patient at significant risk, and may confuse the research results.
study of bms-582664 in combination with either folfiri or folfox for gastrointestinal (gi) malignancies

Conditions: Gastrointestinal Neoplasms

Summary: the purpose of this study is to define the recommended dose of bms-582664 that could be safely combined with 5-fluorouracil, leucovorin, and irinotecan (folfiri) or 5-fluorouracil, leucovorin, and oxaliplatin (folfox) chemotherapy regimens in patients with advanced gastrointestinal malignancies and to evaluate the safety profile, tolerability, pharmacokinetics (pk) and pharmacodynamics (pd) of these combinations.


Eligibility criteria:
inclusion criteria: * good performance status * advanced colorectal, pancreatic, esophageal or gastric cancer * tissue for analyses * adequate bone marrow, hepatic, renal function * 4-6 weeks since prior therapy * adequate protection for women of child bearing potential (wocbp) exclusion criteria: * brain metastasis * thromboembolic disease * cardiovascular disease

Keywords: advanced gastrointestinal malignancies
role of cmr-ft in assessment of hcm and athlete's heart.

Conditions: Hypertrophic Cardiomyopathies; Athlete Heart

Summary: using cardiac mri feature tracking to asses myocardial motion differences in athlete's heart and discovered hypertrophic cardiomyopathy patients to increase diagnostic accuracy of hypertrophic cardiomyopathy.

cardiac mri is the gold standard for assessing cardiac function without significant limitations of anatomical restrictions. cmr-ft helps in assessment of myocardial deformation on routinely obtained by steady state free precision (ssfp) cine images. cmr-ft is used in cardiac research and became common in clinical practice. it has been used in assessment of wide spectrum of cardiac diseases and provides for comprehensive and reliable assessments of heart function.

Eligibility criteria:
inclusion criteria: * patients suspected to be hypertrophic cardiomyopathy by echocardiography.. * athletes and heavy workers,, healthy volunteers also included. exclusion criteria: * patients with absolute or relative contraindications to magnetic resonance imaging (e.g intra-ocular metallic foreign body, claustrophobia, etc) or contra-indication to mri contrast medium. * clinical morbidities with absolute contraindication to anesthesia during the examination in un-cooperative patients where sedation is required.

Keywords: cardiac mri feature tracking hypertrophic cardiomyopathy athlete's heart
the effectiveness of modified 3d printed customized facemask appliance for treatment of class iii malocclusion

Conditions: Jaw Protrusions

Summary: a randomized clinical trial to introduce a modified 3d printed customized maxillary protraction facemask and evaluate its efficacy in comparison with the conventional maxillary protraction facemask therapy in correction of class iii malocclusion of young patients

it is a multicenter randomized clinical trial with two parallel arms. the patients will be randomly divided into two groups, group one: conventional facemask appliance will be used while group two, the modified facemask appliances. lateral cephalometric x-ray, study models, photographs, and patient questionnaire will be taken before starting the treatment (t0) and at the end of treatment (t1). the effectiveness of the two appliances will be assessed and measured comparing patient's records before and after treatment.

Eligibility criteria:
inclusion criteria: 1. skeletal and dental relationships: skeletal class iii with retrognathic maxilla and normal mandible with overjet \< 0 mm. 2. concave profile with normal lower facial height (clinically and radiographically). 3. good oral health free from caries and periodontal problems at the start of treatment. exclusion criteria: 1. previous history of orthopedic and/or orthodontic treatment. 2. patients with vertical growth pattern or backward mandibular rotation tendency. 3. patients with gross facial asymmetry. 4. patients with cleft lip and palate and/or craniofacial syndrome 5. patients with bad oral habit. 6. active periodontal disease. 7. previous history of tmj signs or symptoms

Keywords: orthopedic appliance maxillary protraction petit facemask cl iii malocclusion
a trial investigating the effect of nn1250 in japanese subjects with type 1 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 1

Summary: this trial is conducted in japan. the aim of this clinical trial is to investigate the effect of nn1250 (insulin degludec) in japanese subjects with type 1 diabetes.


Eligibility criteria:
inclusion criteria: * type 1 diabetes mellitus (as diagnosed clinically) for at least 12 months * treated with multiple daily insulin injections or continuous subcutaneous insulin infusion (csii) for at least 12 months * current daily basal insulin requirement above or equal to 0.3 (i)u/kg/day * glycosylated haemoglobin a1c (hba1c) below or equal to 10.0% (one retest within a week is permitted with the result of the last test being conclusive) exclusion criteria: * subject who has donated any blood or plasma in the past month or more than 500 ml within 3 months prior to screening * surgery or trauma with significant blood loss (more than 500 ml) within the last 3 months prior to screening * smoker (defined as a subject who is smoking more than 5 cigarettes or the equivalent per day) * not able or willing to refrain from smoking and use of nicotine gum or transdermal nicotine patches during the inpatient period (only clamp period)
study of povidone iodine to reduce pulmonary infection in head trauma and cerebral hemorrhage in intensive care unit

Conditions: Ventilator Associated Pneumonia

Summary: head trauma and severe cerebral hemorrhage are major risk factors for development of ventilator-associated pneumonia. in a previous open labelled, single center study the investigators showed that repeated oropharyngeal decontamination with povidone-iodine may be an effective strategy to decrease the prevalence of ventilator-associated pneumonia in patients with head trauma. the present study aims to confirm these results in a multicenter, double blind study including patients suffering from head trauma or cerebral hemorrhage.


Eligibility criteria:
inclusion criteria: * adults \> 18 years * closed head trauma with a glasgow coma score \<=8 or cerebral hemorrhage with a glasgow coma score of \<=8 * expected need mechanical ventilation for \>=2 days * written informed consent from the patient's next-of-kin. if no relative is present at the time of inclusion, the patients will be included according to the emergency procedure exclusion criteria: * impossibility to perform oropharyngeal decontamination within 12 h following the initial episode * facial injury with impossibility to perform the oropharyngeal decontamination * tetraplegia * known history of reaction to iodine * respiratory disease or pulmonary infiltrate(s) at inclusion * need for curative antibiotics * mercurial antiseptics treatment * pregnancy
comparing the picco monitor to the non-invasive biobeat (bb)-316pw in icu patients

Conditions: Critically Ill; Hemodynamic Instability

Summary: the aim of this study is to compare hemodynamic monitoring using the invasive picco device to the bb-613pw wireless, non-invasive ppg-based device, in critically ill patients within the icu, suffering from hemodynamic instability and in need of vasopressor support. data will be gathered prospectively and analysed retrospectively.


Eligibility criteria:
inclusion criteria: * icu adult patients in the need of vasopressor support of more than 0.2 mcg/kg/min for a period longer than 3 hours * patients in which picco monitoring is needed exclusion criteria: * refusal of the subject * technical difficulties in insertion of the picco catheters * significant cardiac arrhythmias * significant valvular disease * pregnancy

Keywords: critically ill patients blood pressure vital signs non-invasive monitoring vasopressor support
preoperative hip knee anxiety sleep study

Conditions: Anxiety; Sleep; Surgery

Summary: this study is about assessing the impact of reading previous patients' stories related to their hip or knee replacement surgery on patients' preoperative anxiety and sleep. this provision of previous patients' stories is part of an ongoing perioperative qi project in the regional anesthesiology division.

this will be a pre-post experimental design study. the pre-intervention group of 80 hip or knee replacement surgery patients will receive the amsterdam preoperative anxiety and information scale (apais) and pittsburgh sleep quality index (psqi) in preop holding prior to having their block for their surgery. the block resident will give and collect the scale and inventory to patients. patients are given these surveys as part of a quality improvement initiative, independently of this study. the survey data will be entered into the secure electronic research database. following this, the post-intervention group of 80 patients will be given copies of previous patients' stories at their last visit to the surgeon's office prior to their surgery. these stories will be administered to all hip and knee surgery patients as part of the new standard of care due to a perioperative qi initiative, independently of this study taking place. these subjects will also receive the apais and psqi for assessment in preop holding prior to their block for surgery, as part of the new standard of care. a third party broker will then de-identify the survey data and provide it to the research team for analysis. a two-sided independent t-test will be performed to evaluate the differences in anxiety and sleep scores between the pre- and post-intervention groups.

Eligibility criteria:
inclusion criteria: * planned to undergo a hip or knee replacement surgery at henry ford hospital exclusion criteria: * diagnoses involving sleep disturbance or psychiatric anxiety

Keywords: preoperative sleep anxiety hip surgery knee surgery storytelling
dao deficiency screening among patients with insomnia symptoms

Conditions: Insomnia; Insomnia Disorder

Summary: insomnia is prevalent in the global population. diamino oxidase (dao) is an enzyme that degrades histamine. when there is not enough dao enzyme activity in the body, histamine accumulates and it can lead to symptoms in the nervous system, among others. in this study we wanted to study the prevalence of dao deficiency in pacients with insomnia symptoms.


Eligibility criteria:
inclusion criteria: * older than 18 years old * with one or more symptoms of insomnia * explicit acceptance to participate to the study through informed consent exclusion criteria: * insomnia symptoms that could be justified by the existance of another sleep pathology (e.g., narcolepsy)
peroneal nerve dysfunction in epiphyseal transfer

Conditions: Epiphyseal Arrest

Summary: assessment of peroneal nerve dysfunction after proximal fibular epiphyseal resection and evaluation of clinical outcome and emg changes.

in children the preserved epiphysis of the proximal fibula ensure the exceptional ability to recover both joint function and longitudinal limb growth at the same time. traumatic bone defect, congenital malformations, malignant bone lesions and infection are all current indications for vfet. the shape and size of the proximal fibular epiphysis aid in the gradual remodeling of the articular surface, allowing for better reconstruction and eventual rehabilitation over time. harvesting the proximal epiphysis of the fibula, along with its intact blood supply, is technically demanding, and the success of vfet is a primarily dependent on restoring adequate vascularity to the growth plate and diaphysis. anterior tibial artery is the primary and most consistent contributor to the proximal fibular epiphysis and proximal two thirds of diaphysis, it has intimate connection to the motor (deep) branch of peroneal nerve. the success of anterior tibial artery based vfet based on preserving the anterior tibial vascular bundle, so it may be necessary to sacrifice some branches of peroneal nerve to tibialis anterior muscle. this is a significant flaw in the approach that could result in permanent peroneal nerve palsy.

Eligibility criteria:
inclusion criteria: * all patients candidate for epiphyseal transfer are included ( patients with traumatic bone defect, congenital malformations, malignant bone lesions and infection ) exclusion criteria: * patients in which there's no injury of nerve supply of tibialis anterior has occurred intraoperative
microbial composition of breast milk collected from healthy turkish women

Conditions: Microbial Community in Breast Milk

Summary: breast milk is an optimal source of nutrients for newborns as well as a potential source of bacteria for the intestinal microbiota. however, there are limited number of studies evaluating the relationship between maternal nutrition, breast milk and neonatal intestinal microbiota.

the study was conducted on a total of 20 healthy women following at obstetrics and gynecology department of gülhane education and research hospital in ankara health sciences university. sociodemographic characteristics, anthropometric measurements, breastfeeding characteristics were evaluated in the third trimester of the women who underwent routine prenatal care. breast milk samples were obtained at 16.day postpartum during lactation.

Eligibility criteria:
inclusion criteria: * singleton pregnancy * age 19-35 years * at weeks of 30-36 gestation * no history of acute or chronic diseases * term delivery exclusion criteria: * alcohol use * smoking * gestational diabetes * type 1 and 2 diabetes * preeclampsia * polycystic ovary * syndrome * thyroid and parathyroid disease * metabolic bone or kidney disease * abnormal liver function * multiple pregnancy * premature and postmature labor * having chemotherapy * taking drugs such as antibiotics and probiotics

Keywords: breast milk microbiota