Kornimate/medical-research-clean huggingface dataset:
efficacy of the extracorporeal shock wave therapy in athletes with patellar tendinopathy

Conditions: Patellar Tendinopathy; Patellar Tendon Pain

Summary: the aim of this study is to investigate the effectiveness of extracorporeal shock wave therapy (eswt) in addition to eccentric exercise on the clinical outcomes of pt in the treatment of athletes with patellar tendinopathy (pt). participants will be randomly divided into two groups. the intervention group will receive focus eswt 3 times a week in addition to 6 weeks of exercise. the control group will be given 6 weeks of exercise. evaluations will be made at the 3rd and 6th weeks, and at the 3rd, 6th and 12th months. patient evaluation will begin with obtaining sociodemographic information. patients' pain level will be assessed using visual analog scale (vas), tendon pain and function visa-p, functional capacity; the patients will be assessed with the maximal vertical jump test (mds), single leg jump distance test (slhd), single leg squat test (sts) on the incline board, pain catastrophe with the pain catastrophe scale (pcs), kinesiophobia with the tampa kinesiophobia scale (tks), quality of life short form-12 (sf-12) and physical activity level with the tegner activity scale (tas).


Eligibility criteria:
inclusion criteria: * localized pain in the inferior pole of the patella during single-leg squatting due to load, * pain or tenderness with palpation of the patellar tendon, * complaints of pain in the patellar tendon due to training, competition or physical activity in the last 6 months, * performing sports/physical activities related to jumping and landing, * professional and recreational athletes who perform at least 5 and above according to the tegner activity score, * visa-p scale score \<80 out of 100. exclusion criteria: * presence of other knee pathologies, * known presence of inflammatory joint diseases or familial hypercholesterolemia, * daily use of drugs with presumed effects on the patellar tendon (e.g. fluoroquinolones) in the last 12 months, * local injection therapy with corticosteroids in the last 12 months, * previous patellar tendon rupture, * any lower extremity surgery in the last 6 months.

Keywords: exercise extracorporeal shock waves therapy pain patellar tendinopathy
retinal imaging by adaptive optics in healthy eyes and during retinal and general diseases

Conditions: Retinal Dystrophies; Age-related Macular Degeneration; Arterial Hypertension; Diabetes; Traumatic Retinopathy; Toxic Retinopathies

Summary: using an adaptive optics imaging device, retinal structures are observed in healthy and diseased subjects.

most cases of severe visual loss in developed countries are due to retinal diseases affecting a specialized class of neurons, the photoreceptors. currently available systems for retinal imaging in humans do not allow neuronal imaging at the cellular level, which is crucial to understand, diagnose and monitor retinal diseases. in recent years, adaptive optics (ao) fundus imaging has proven its capability to image individual photoreceptor cells in the human retina. this technology is now reaching technical maturation. a prototypic ao system (manufactured by imagine eyes) is currently in operation in a clinical setting (clinical investigation center 503) and has proven its reliability to monitor single photoreceptors over time. yet, the clinical evaluation of ao imaging is still in its infancy, and biomarkers issued from ao imaging have not been validated. the goal of the iphot project is thus to optimize the process of ao imaging (from the implementation of novel technical solution to image processing and data analysis) in order to obtain morphological, quantitative and longitudinal information concerning retinal microstructures in humans. for instance, we will aim at detecting early photoreceptor damage during retinal dystrophies.

Eligibility criteria:
inclusion criteria: * over 10 years old exclusion criteria: * ocular media opacities, unstable fixation

Keywords: photoreceptors retinal pigment epithelium adaptive optics
confrontation phenotypes and genotypes of epithelial odontogenic tumors of the jaws

Conditions: Epithelial Odontogenic Tumours

Summary: systematically compare the phenotype and genotype of epithelial odontogenic tumors in children and adults with a clinical, radiographic, pathologic and molecular level. either: establish an observatory of this multidisciplinary tumor establish a tumor bank annotated scale unparalleled testing pathophysiological hypotheses search for prognostic factors.

this is an observational study with retrospective and prospective parts. in retrospective part be included the patients followed between 1992 and january 2011. in prospective part will follow the patients will be included after the starting of study. there are 2 centers : 1. st center is in the service of stomatology and maxillofacial surgery in the pitie salpetriere hospital. 2. nd center is in the service of maxillofacial surgery in hospital armand trousseau. number of patients include in the part retrospective : center n°1-300adults center n°2-90childrens number of patients include in the part prospective : center n°1- 90 center n°2- 30 duration of study is 3 years duration of inclusion is 32 months each patient will be followed for 4 months and for further up to 3 years from the first patient included. we envision a next circuit : obtaining consent, preoperative consultation,surgery, postoperative consultation n°1, postoperative consultation n°2, genetics consultation and monitoring of patients in 6;12;18;24 months from surgery of tumor and limited in 3 years from th 1st patient included.

Eligibility criteria:
inclusion criteria 1. patient with an osteolytic lesion of the jaws 2. patient with epithelial odontogenic tumor: keratocysts ameloblastoma pindborg tumor or calcifying (eswt) epidermoid (squamous odontogenic tumor sot) clear cell (clear odontogenic tumor cells ccot) 3. patient monitoring in the period 1992 to january 2011 at the trousseau hospital (children) or at the pitie salpetriere (adult) 4. patient aged 5 years or more 5. adult patient who had signed informed consent 6. holders of parental authority of minor patient were informed and signed consent non inclusion criteria 1. patient with an osteolytic lesion of dental origin inflammatory (adjacent teeth decayed, non-living mortified) 2. patient with a cyst fissure (nasopalatine, symphyseal or globulomaxillary) 3. patient with arteriovenous malformation, vascular 4. patient with cons-indication to mri 5. patient not affiliated with a social security scheme (beneficiary or assignee) 6. pregnant woman 7. patient in his history of hypersensitivity to salts of gadolinium 8. patient receiving a measure of legal protection

Keywords: maxillofacial surgery epithelial odontogenic tumours
paracetamol oral paediatric suspension at 4.8% : study of acceptability and safety.

Conditions: Fever; Pain

Summary: evaluate the acceptability over 24 hours of a new paracetamol formulation 4.8% paediatric oral suspension in children weighing between 3 and 26 kg including limits


Eligibility criteria:
the following information on clinical trials is provided for information purposes only to allow patients and physicians to have an initial discussion about the trial. this information is not intended to be complete information about the trial, to contain all considerations that may be relevant to potential participation in the trial, or to replace the advice of a personal physician or health professional. main criteria are listed hereafter : inclusion criteria: * children of both sexes weighing between 3 and 26 kg including limits. * with a fever and/or painful episode justifying a paracetamol treatment for a minimum duration of 24 hours. * likely to be followed throughout the entire study period in out-patient. * for whom the informed consent has been signed by the parents or legal guardian and by the child if old enough (see chapter 12.3). exclusion criteria: * presenting digestive disorders, vomiting. * presenting a hypersensitivity to paracetamol or one of the ingredients of the study product * presenting a hepatocellular failure. * presenting a fructose intolerance. * presenting a serious concomitant disease, such as cancer, immune deficiency or a serious renal, hepatic cardiac, neurological, psychiatric or metabolic disease. * presenting a history of significant biological anomalies. * treated with kayexalate® (sodium polystyrene sulphonate) * not covered by a social security regime. * whose parents are incapable of understanding * who cannot come back to the consultation for the final evaluation and/or submit to the study constraints. * who participated in another clinical study in the 30 days prior to inclusion. * is a relation of the investigator.
stem cell therapy to improve myocardial function in patients with acute myocardial infarction

Conditions: Myocardial Infarction

Summary: the purpose of the study is to compare the efficiency of a sorted subpopulation of cd34+/cxcr4+ cells and unselected bone marrow-derived progenitor cells in the treatment of patients with acute myocardial infarction and a low left ventricular ejection fraction.

aim is to compare the efficiency of sorted subpopulation of cd34+/cxcr4+ cells and unselected bone-marrow-derived progenitor cells in treatment of patients with acute myocardial infarction and low left ventricular ejection fraction. the subpopulation of cd34+/cxcr4+ cells most likely contains the tissue-specific stem cells likely to be involved in myocardial salvage/regeneration after ischemic injury. this approach is novel and original, because so far no study identified the type of cells that actually contribute to stem cell-induced improvement in myocardial function in patients with ami which were treated with unselected population of cells. the regent trial (prospective, randomized, multicentre trial comparing unselected bm mononuclear cells and sorted cd34/cxcr4+ cells in patients with myocardial infarction and low left ventricular ejection fraction) successfully treated with primary percutaneous coronary angioplasty within 12 hours after the onset of chest pain. the cells are delivered by intracoronary infusion. efficiency is assessed by cardiac magnetic resonance imaging, echocardiography and left ventricular angiography.

Eligibility criteria:
inclusion criteria: * acute myocardial infarction treated successfully with primary coronary angioplasty * left ventricular ejection fraction less than 40% * informed consent granted exclusion criteria: * presence of significant coronary stenoses in non-infarct related artery requiring revascularization * cardiogenic shock * previous myocardial infarction * age \ 75 years * pregnancy * neoplasm * contraindications for mri

Keywords: stem cells acute myocardial infarction regeneration left ventricular ejection fraction
assessment of liver diseases using a deep-learning approach based on ultrasound rf-data

Conditions: Artificial Intelligence; Ultrasonography; Elasticity Imaging Techniques; Liver Diseases; Metastasis to Liver

Summary: the goal of this clinical trial is to test the performance of neuronal networks trained on ultrasonic raw data (=radiofrequency data) for the assessment of liver diseases in patients undergoing a clinical ultrasound examination. the general feasibility is currently evaluated in a retrospective cohort. the main questions the study aims to answer are: * can a neuronal network trained on rf data perform equally good as elastography in the assessment of diffuse liver diseases? * can a neuronal network trained on rf data perform better than a neuronal network trained on b-mode images in the assessment of diffuse liver diseases? * can a neuronal network trained on rf data distinguish focal pathologies in the liver from healthy tissue? to answer these questions participants with a clinically indicated fibroscan will undergo: * a clinical elastography in case ob suspected diffuse liver disease * a reliable ground truth (if normal ultrasound is not sufficient e.g. contrast enhanced ultrasound, biopsy, mri or ct) in case of focal liver diseases, depending on the standard routine of the participating center * a clinical ultrasound examination during which b-mode images and the corresponding rf-data sets are captured


Eligibility criteria:
inclusion criteria: * scheduled for an ultrasound investigation by an independent physician * signed declaration of consent exclusion criteria: * smaller interventions in the same liver during the last 2 week (for example liver biopsy) * contrast enhanced ultrasound less than a day ago * major intervention at the liver (for example partial resection)

Keywords: quantitative ultrasound radiofrequency data
perfusion, oxygen consumption and energetics in adpkd (penguin)

Conditions: Polycystic Kidney Disease, Adult; Polycystic Kidney, Autosomal Dominant

Summary: autosomal dominant polycystic kidney disease (adpkd) is the most common monogenic cause of end-stage kidney disease (eskd). the disorder is characterized by development and continued growth of multiple cysts requiring renal replacement therapy in 50% of patients by age 60 years. however, adpkd is also a complex metabolic disorder defined by insulin resistance (ir) and mitochondrial dysfunction which may be causally related to cyst expansion, kidney function decline and contribute to reduced life expectancy. renal hypoxia, stemming from a potential metabolic mismatch between increased renal energy expenditure and impaired substrate utilization, is proposed as a novel unifying early pathway in the development and expansion of renal cysts in adpkd. by examining the interplay between renal o2 consumption and energy utilization in young adults with and without adpkd, the investigators hope to identify novel therapeutic targets to impede development of cyst expansion in future trials. the investigators propose to address the specific aims in a cross-sectional study with 20 adults with adpkd (50% female, ages 18-40 years). comparative data will be provided from healthy adults from an ongoing study with similar study design and methods (crocodile study: control of renal oxygen consumption, mitochondrial dysfunction, and insulin resistance). for this protocol, participants will complete a one day study visit at children's hospital colorado. patients will undergo a dual energy x-ray absorptiometry (dxa) to assess body composition, and a 11c-acetate positron emission tomography (pet/ct) scan to quantify renal o2 consumption. after the pet/ct, participants will undergo a hyperinsulinemic-euglycemic clamp while fasting to quantify insulin sensitivity. glomerular filtration rate (gfr) and effective renal plasma flow (erpf) will be measured by iohexol and pah clearances during the hyperinsulinemic-euglycemic clamp.


Eligibility criteria:
inclusion criteria: * patients with autosomal dominant polycystic kidney disease * age 18-40 years * bmi \>= 18.5 and \<30 kg/m2 * weight \<350 lbs exclusion criteria: * diabetes mellitus, based on previous diagnosis * albuminuria (≥30mg/g) or estimated glomerular filtration rate (egfr) \<75ml/min/1.73m2 * pregnancy or nursing * anemia * allergy to shellfish or iodine * vaptan therapy (e.g. tolvaptan) * uncontrolled hypertension (average ≥140/90 mmhg)
use of supar algorithm for the ed decision making

Conditions: Critical Illness

Summary: will the use of a clinical decision algorithm in the ed improve discharge or admission decisions.

background crowding and readmissions are common challenges in emergency departments across europe. the decision whether to admit or discharge the patient is challenging and is often based on clinical signs and symptoms e.g. blood pressure, pulse, respiratory rate, oxygen saturation and temperature. but some patients are unnecessarily admitted and may have been better off if sent home. other patients may be discharged without - and one out of five patients are readmitted within a month raising the question whether the patient should have been admitted at first presentation in the ed. supar is a strong prognostic biomarker measured routinely in acute medical patients in some emergency department (ed) settings.supar is a broadly applicable biomarker of risk, and it has been developed an algorithm for simple interpretation of supar in clinical decisions for the study. objective to evaluate the use of a clinical decision algorithm in the ed with the aim of improving discharge or admission decisions.

Eligibility criteria:
inclusion criteria: * all patients above 18 years * who are having blood taken for biochemical analysis when attending the ed exclusion criteria: * acute medical patients that do not have blood drawn for routine biochemical testing. * pregnant * under 18 years old * terminally ill patients.

Keywords: ed critical illness decision making poc test supar
randomized, double-blind, placebo-controlled, with phx1149 in patients with type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: this will be a 4-week, multicenter, randomized, double-blind, parallel group, placebo-controlled, safety, tolerability, and efficacy study. patients will be screened and be on one of three doses of phx1149 (a new drug candidate for the treatment of type 2 diabetes ) or placebo. the drug is a "dpp4 inhibitor"


Eligibility criteria:
inclusion criteria: * type 2 diabetes mellitus treatment with metformin +/- tzd exclusion criteria: * type 1 diabetes mellitus
periodized resistance and aerobic training in non-specific chronic low back pain

Conditions: Low Back Pain

Summary: the aim of the study is to compare the effectiveness of two forms of periodized exercise training programs (resistance and aerobic ) using the best recommended parameters (volume, intensity, rest period, and frequency) on the best available outcome measures (pain, disability, fear of movement, back and abdominal muscular endurance, upper body strength (latissimus dorsi muscle),and lower body strength ( gluteus maximus )

low back pain (lbp) is a significant health problem and the leading cause of disability throughout the world, representing one of the most common reasons for primary care physician visits, with a lifetime prevalence reported as high as about 80%. it causes a significant economic and social burden that will become even more daunting in the coming decades. people with lbp are 2.5 times more likely to experience psychological distress and pain compared to normal people, which can adversely affect quality of life. low back pain is commonly classified as nonspecific or specific due to the reported cause and as acute (\ 12weeks) according to the duration of symptoms. a periodized training model is considered more effective at improving the physiological function than non-periodized (basic progressive overload), as it allows progressive adjustment of volume and intensity of training program.periodization is defined as the planned manipulation of training variables (load, sets, and repetitions) in order to maximize training adaptations and to prevent the onset of overtraining syndrome. various periodization models exist: undulating periodization comprises a frequent variation in stimuli between low, moderate, and high intensity typically on a weekly basis, whereas traditional linear periodization typically contains low load and high volume in the initial phase of training with a gradual shift towards high load and low volume as the training progresses. periodization may also be beneficial due to adding variation to workouts by manipulating sets, repetitions, exercise order, number of exercises, resistance, rest periods, type of contractions, or training frequency. another added benefit is the avoidance of training plateaus or boredom. thus it seems reasonable to consider a periodized training model in the management of those with nsclbp.

Eligibility criteria:
inclusion criteria: * male or female participants with nonspecific (nonspecific pathology) chronic (\> 12 weeks) low back pain (localized below the costal margin and above the gluteal fold) (owen et al., 2020). * participants aged between 18 to 45 years (wewege et al., 2018). * participants with body mass index (bmi) 18.5-29.9 kg/m2. * vas score 3-8 cm (pieler-bruha, 2009). * odi score 10-60 (pieler-bruha, 2009). exclusion criteria: * participants will be excluded if they did not meet the inclusion criteria mentioned above such as pain due to or associated with: * pregnancy * infection * fracture * tumor * structural deformity (e.g. scoliosis) * radicular syndrome or cauda equine syndrome * inflammatory disorders (owen et al., 2020)
comparing short-term function and pain after no treatment or splinting for boxer's fracture

Conditions: Metacarpal Fractures

Summary: this study is being done because the investigators would like to know if pain and hand function after having a boxer's fracture differs between being treated with supportive splinting or without splinting, but with behavioral modifications.

after initial treatment in the emergency department, patients with boxer's features are referred to the division of plastic and reconstructive surgery at sunnybrook hospital. during initial consultation with the hand surgeon, treatment is chosen. patients are follow-up with their hand surgeon at 4-, 8-, and 12--week intervals. supportive splinting: patient's are given a removable plaster/fiberglass splint with a tensor bandage underneath. behavioral modifications: patients are not splinted, but provided a tensor bandage. patients are instructed on specific behaviours to prevent movement of the injured part of the hand. the purpose of the study is to compare pain and short-term hand function in patients who undergo supportive splinting compared to patients who undergo behavioral modifications treatment only to see which option is associated with shorter functional recovery and which option is associated with less pain during the first 4 weeks after initial treatment. on follow-up appointments at 4, 8,and 12 weeks, as well as initial consultation with the hand surgeon, participants will be asked to perform a grip strength test with a jamal hydraulic hand dynanometer. participants will be asked to fill out a brief michigan hand questionnaire along with the grip strength test as well as quick demographics survey at initial consultation with the hand surgeon. after the 12-week follow up appointment, study participation will end. if a patient is unable to follow-up with the hand surgeon, the brief michigan hand questionnaire will be done via phone whenever is most convenient for the patient. it's anticipated that about 40 people will participate in this study at a single centre in toronto.

Eligibility criteria:
inclusion criteria: * diagnosis of true boxer's fracture * candidate for either supportive splinting or tensor bandage * speaking, read and write english exclusion criteria: * prior surgical treatment for boxer's fractures or other hand conditions. * concurrent hand/wrist injury

Keywords: fracture follow-up metacarpal