Kornimate/medical-research-clean huggingface dataset:
assessment of prognosis using peripheral blood circulating tumor dna in patients with cervical cancer

Conditions: Locally Advanced Cervical Cancer

Summary: this observational study is conducted to assess the value of using peripheral blood ctdna to detect dynamic changes in hpv and genetic variants in predicting the prognosis of patients with locally advanced cervical cancer, as compared with traditional imaging and tumor markers.

the goal of this study is to assess the prognostic value of ctdna hpv and gene variant clearance in peripheral blood. two cohorts will be enrolled: operable group and radical chemoradiotherapy group. after enrollment, patients will receive standard treatment and follow-up strategy. peripheral blood samples will be collected from 2 cohorts of patients before treatment and at different time points after starting treatment. baseline surgical or puncture tissues will be also obtained. peripheral blood ctdna and baseline tissues will be tested for hpv copy number based on ddpcr and genetic variation based on next-generation sequencing (ngs). finally, the correlation of ctdna hpv and genetic variation clearance with patients prognosis and its value for recurrence monitoring compared to traditional tumor markers and imaging examination will be analyzed.

Eligibility criteria:
inclusion criteria: * patients with initial diagnosis, operable locally advanced cervical cancer, figo stage ib2/3-iia1/2 or initial diagnosis, receive radical chemoradiotherapy locally advanced cervical cancer, figo stage iib-iva * not receiving systemic treatment * pathological diagnosis: cervical squamous cell carcinoma * aged 18-70 years * ecog ps: 0-1 * patients volunteer to participate in this study and sign the informed consent, with good compliance, and cooperate with the acquisition of tissue samples and blood samples exclusion criteria: * patients diagnosed with other malignancies within 5 years * patients had received previous systemic antitumor therapy * in the judgment of the investigator, the patients had other factors that might have caused the study to be discontinued
pf-06671008 dose escalation study in advanced solid tumors

Conditions: Neoplasms

Summary: the study will evaluate the safety, pharmacokinetics and pharmacodynamics of increasing doses of pf-06671008 in patients with advanced solid tumors with the potential to have p-cadherin expression. the study will then expand to look at the selected dose in patients with p-cadherin expressing tnbc, crc or nsclc.


Eligibility criteria:
key inclusion criteria * diagnosis of tumor type with the potential to have p-cadherin expression that is resistant to standard therapy or for which no standard therapy is available * performance status of 0 or 1 * adequate bone marrow, kidney and liver function key exclusion criteria * known cns disease including, but not limited to, metastases * current or history of seizure disorder * history of or active autoimmune disorders * active bacterial, fungal or viral infection * major surgery, anti-cancer therapy, or radiation therapy within 4 weeks of study treatment * requirement for systemic immune suppressive medication * grade 2 or greater peripheral neuropathy

Keywords: p-cadherin pf-06671008 solid tumors lung cancer breast cancer colorectal cancer nsclc tnbc crc neoplasms triple negative breast cancer non-small cell lung cancer
chest u/s in differentiating lung congestion & pneumonia in adult critically-ill patients and its prognostic impact

Conditions: Pneumonia; Pulmonary Edema

Summary: this study aim will be to assess the effectiveness of chest ultrasound as a diagnostic and differentiating modality in cases of pneumonia and lung congestion . it also evaluates chests sonography effectiveness in follow-up of patients with pneumonia and lung congestion .

lung ultrasound (lus) is used at the bedside in emergency and critical care settings. it is a rapid and low-cost approach that can direct patient care without the use of harmful radiation. the success of this technique depends on its simplicity to discover the sonographic signs which indicate certain lung pathology. these signs include a hyperechoic and sliding line, moving forward and back with ventilation seen 0.5 cm below the rib line and is called the pleural line. the a-profile associates anterior lung sliding with a lines. a lines are horizontal repetition artifacts of the pleural line. the b-profile associates anterior lung sliding with b lines. b lines appear as shining vertical lines arising from the pleural line and reach the edge of the screen. several pathological etiologies can fill the alveolar spaces, with fluid (heart failure), pus (pneumonia which is the commonest), blood (pulmonary hemorrhage), and cells (lung cancer). other causes of lung consolidation may include atelectasis, pulmonary edema, infarction, and lung cancer. chest imaging with ct is regarded as the gold standard modality allowing for the diagnosis of pneumonia in earlier stage and with higher sensitivity and specificity. on the contrary, cardiogenic pulmonary edema (cpe) is defined as alveolar transudation caused by elevated pulmonary capillary hydrostatic pressure secondary to increased pulmonary venous pressure with low-protein content in the interstitial tissue of lung as a result of cardiac dysfunction

Eligibility criteria:
inclusion criteria: * adult (above 18 years old) * both genders * patient with symptoms suggestive of pneumonia * patient with symptoms suggestive of acute congestive heart failure * admitted to critical care unit exclusion criteria: * patients with renal induced lung congestion
efficacy of flomax to improve stone passage following shock wave lithotripsy

Conditions: Urolithiasis

Summary: the majority of kidney stones are treated with shock wave lithotripsy (swl). we are examining if the medication flomax will result in improved stone passage rates following swl.

placebo blinded study examining the effects of flomax on stone passage rates following swl.

Eligibility criteria:
inclusion criteria: * patients 18 years old and above with urolithiasis scheduled for shock wave lithotripsy. exclusion criteria: * contraindications to flomax * patients with renal impairment (serum creatinine above 2.0) * patients with hepatic impairment (liver enzymes 2.5 times the upper limit of normal) * use of other oral alpha blockers

Keywords: urolithiasis
impact of anti-inflammatory and antibiotic therapy on the emergence of peri-tonsillar abscess

Conditions: Abscess, Peritonsillar

Summary: analyze in children and adults, risk factors in the onset of the apa. the main hypothesis focuses on the use of anti-inflammatory in the context of pharyngitis or sore throat before the symptoms of abs. secondary objectives: 1. - analyze the implementation of a rapid diagnostic test and its result on the occurrence of an abs 2. - measure the frequency of prescription and describe the reasons for not prescribing an antibiotic for patients who consulted for a sore throat and having developed a pla 3. - describe the microbial flora could puncture of patients hospitalized for apa


Eligibility criteria:
inclusion criteria: * clinical existence of a pla (phlegmon), validated by a senior ent, usually (but not necessarily) following a request by an emergency. the visible appearance to the merits throat must justify puncture. cases will be included whether or not they had consulted for a "sore throat" in the 10 days preceding the date of diagnosis exclusion criteria: * neoplastic disease of the throat, scalable hematologic with tonsillar localization history of tonsillectomy
ultrasound guided hematoma block in distal forearm fractures

Conditions: Forearm Fracture

Summary: this is a randomized control trial comparing the efficacy of ultrasound (us) guided vs landmark-guided hematoma blocks on distal forearm fractures.


Eligibility criteria:
inclusion criteria: * patients greater than and equal to seven years of age * patients with traumatic acute distal radius/ulnar fractures with displacement that require reduction and immobilization with splinting * patients that receive distal radius hematoma blocks, including those who require additional pain control adjuncts if pain control is not adequate exclusion criteria: * prisoners * pregnant women * patients with altered mental status/have impaired decision-making capacity. * patients with allergies to amide anesthetics

Keywords: ultrasound hematoma block
online psychosocial support for young people with a visible difference: a randomised control study

Conditions: Skin Condition; Cleft Lip and Palate; Burns; Other Conditions Leading to a Visible Difference; Craniofacial Abnormalities

Summary: a visible difference can have a profound impact in a society with a massive emphasis on appearance and "looks". a vulnerable group is adolescents with a condition affecting their appearance as a result of injuries (burns, accidents), treatment (cancer), skin conditions or congenital anomalies (birthmarks, craniofacial conditions). research has identified potential psychological difficulties, which, if not addressed, can lead to anxiety, depression, and eating disorders. in addition to medical treatment options, aiming at diminishing a difference that may be visible to others, young people with appearance concerns also need self-management skills. however, evidence-based interventions are scarce and specialised psychological treatment is difficult to reach. the centre for appearance research (bristol, uk) has developed an online intervention for adolescents, now translated into norwegian (www.ungfaceit.no). ung face it provides easy access to specialist advice and support via a home computer, using information, videos, and interactive activities. it provides advice, teaches coping and social skills, strengthening psychological adjustment to a visible difference. a systematic evaluation of the norwegian version is needed. ung face it could potentially address unmet needs, provide a cost-effective tool to reduce the need for "face-to-face" psychological and surgical/medical services, and contribute to make online health care available for young people with a visible difference.


Eligibility criteria:
inclusion criteria: * age 12-17 with an appearance-altering condition, and experiencing appearance-related distress, teasing, or bullying * access to a home computer/tablet and internet * reading level \> 12 years of age. audio recordings for all written text available on the website for those who may struggle with reading * normal/corrected-to-normal vision exclusion criteria: * clinical depression, psychosis, eating disorder (alternative support necessary) * post-traumatic stress disorder (ptsd) or within 12 months of traumatic injury (alternative support necessary) * learning disability that would impede understanding of the programme's content * currently receiving psychological intervention
cultural and linguistic adaptation and normative study of the turkish version of the free and cued selective reminding test: 16-word version (fcsrt-t)

Conditions: Dementia; Memory Impairment

Summary: an adaptation study of free and cued selective reminding test in turkish

as very commonly used for objectifying alzheimer disease memory deficits, an adaptive selection of word choices are done for the use of free and cued selective reminding test (fcsrt) procedure in turkish population. in this study the validity and reliability of the test to measure memory deficits in persons with memory complaints will be discussed.

Eligibility criteria:
inclusion criteria: * having memory complaints * demanding clinical consultation for the memory complaint exclusion criteria: * vascular pathology * extrapyramidal findings * psychiatric illness * epilepsy * cognition affecting drug use

Keywords: alzheimer disease memory complaint memory dementia free and cued selective reminding test adaptation validity
application of 3-dimensional printing guide template and pointed lotus-style regulator

Conditions: Vertebral Fracture

Summary: this study aims to analysis the efficacy of the 3d printing percutaneous guide template in combination with the pointed lotus-style regulator in percutaneous pedicle screw fixation.

all thoracolumbar fractures patients receiving percutaneous pedicle screw fixation (ppsf) were enrolled and randomly divided into 3 groups. patients in group a received traditional ppsf, while patients in group b received ppsf with flat end lotus-style regulator and patients in group c received ppsf with pointed lotus-style regulator.

Eligibility criteria:
inclusion criteria: * the thoracolumbar vertebral compression fracture which the injury time is less than 7 days * the vertebral fracture sites where are located in t11-l2 * no clinical neurological symptoms and signs * the patients who have complete preoperative x-ray, ct, mri and other imaging data exclusion criteria: * vertebral burst fracture with spinal canal occupation * fracture caused by severe osteoporosis or tumor and other pathological factors * moderate and severe scoliosis * patients with pedicle dysplasia * patients with severe heart, liver and kidney diseases, diabetes, immune diseases, mental diseases who cannot tolerate surgery * coagulation dysfunction or surgical site of the skin infection

Keywords: 3d printing guide template pointed lotus-style regulator thoracolumbar compression fracture percutaneous pedicle screw fixation
optical coherence tomography (oct) data collection study

Conditions: No Eye Disease

Summary: collect oct data to evaluate the range and age trend of eye measurements.


Eligibility criteria:
inclusion criteria: * at least 18 years of age * able and willing to provide consent * able and willing to complete the required examininations and visit * refractive error within 8 diopters sphere and within 2 diopters cylinder in each eye * best corrected visual acuity of 20/30 or better in each eye exclusion criteria: * history of leukemia, aids, dementia or multiple sclerosis * concomitant use of hydroxycloroquine or chloroquine * family history of glaucoma among first degree relatives * intraocular pressure of 22mm hg or greater in either eye * unreliable or abnormal visual field * active ocular disease * previously diagnosed with glaucoma or glaucoma suspect * congenital ocular abnormalities * previous intra-ocular surgery or laser treatment (other than refractive surgery or uncomplicated cataract surgery greater than 6 months previously) * anatomic narrow angle
lab study of mqx-503 in treatment of raynaud's

Conditions: Raynaud Disease; Raynaud Disease Secondary to Scleroderma; Raynaud Secondary to Other Autoimmune Disease

Summary: the purpose of this study is to determine, in comparison to a placebo control, the response to two dosage strengths of a topical gel formulation of nitroglycerin, mqx-303, in the determination of finger blood flow and skin temperature in the fingers of patients with moderate to severe raynaud's phenomenon, follwoing exposure to cold temperatures. blood flow is determined by scanning laser doppler equipment and skin temperature is measured using attached thermistor probes. following baseline measurements, the study gel is applied, the hand is placed in a cold chamber, and then blood flow and skin temperature are monitored for the next two hours. each patient will receive multiple doses on different days so that each can serve as his/her own control in interpreting the response.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of raynaud's phenomenon * outpoatients * agree to apply gel as per protocol * willing to discontinue current vasodilator therapy * agree to stop other investigational medication for raynaud's * negative pregnancy test is fertile females * able to give written informed consent and comply with study requirements exclusion criteria: * current use of ay nitrate medication or medications that interact with nitroglycerin * patients with a known allergy to nitroglycerin or topical gel ingredients * patients with a history of migraine headaches * patients with unstable medical problems * patients with cognitive or language difficulties * patients with screening lab values more than 20% outside of normal * patients with open lesions at site of application * women of child-bearing potential who are unwilling to comply with contraceptive requirements.

Keywords: raynaud's sclerderma systemic sclerosis autoimmune disease
impact of autologous pure platelet-rich plasma in the treatment of tendon disease

Conditions: Rotator Cuff Tear; Lateral Epicondylitis; Achilles Tendinitis

Summary: this is a randomized parallel controlled double-blind phase 2 clinical study.all subjects are recruited from the patients of rotator cuff tear, lateral epicondylitis or chronic achilles tendonitis. patients will be randomly divided into three groups. autologous pure platlet-rich plasma (p-prp) and platlet-rich plasma (prp) are purified from the peripheral blood .patients of case groups will receive p-prp or prp injection once a week for three times while the control group received the same dose compound betamethasone injection. follow up visit will occur at 1 month,3 months, 6 months,12 months after the last injection. clinical quantitative assessment will measure by the visual analogue scale(vas). the secondary outcomes are the constant-murley score(cms) and the rating scale of the american shoulder and elbow surgeons(ases) and the disability of arm shoulder and hand(dash). the objective evaluation methods is that the examination of mri or ultrasound were accomplished before the first injection and at 6 and 12 months afterwards.

all injection will be done under ultrasound guidance.

Eligibility criteria:
inclusion criteria: 1. clinically diagnosed as rotator cuff tear, lateral epicondylitis or chronic achilles tendonitis; 2. symptom duration is over 3 months, non-steroidal drug treatment , rehabilitation treatment and other conservative treatment is invalid; 3. patient that can understand the clinical trials and signed the informed consent. exclusion criteria: 1. patient that underwent other injection treatment within 6 weeks 2. some associated diseases (such as arthritis, synovitis, entrapment of related nerve, radiculopathy to the target lesion, generalized pain syndrome, rheumatoid arthritis, pregnancy, impaired sensibility, paralysis, history of allergic or hypersensitive reaction to bovine-derived proteins or fibrin glue) 3. patient that enrolled other clinical trials within 3 months 4. history of drug/alcohol addiction, habitual smoker

Keywords: pure platelet-rich plasma randomized controlled trial
chinese version of fibromyalgia criteria and severity scales study

Conditions: Chinese Version; Fibromyalgia; Diagnosis; Fibromyalgia Impact Questionnaire

Summary: up to now, there is no chinese version of fibromyalgia diagnosis criteria and severity assessment scales. the aim of this study is to translate, adapt, and validate the chinese version of the 2011 modification of the 2010 acr preliminary criteria for the diagnosis of fibromyalgia (2011modcr) and 2016 acr revisions to the 2010/2011 fibromyalgia diagnostic criteria, as well as the fibromyalgia impact questionnaire (fiq-c).

fibromyalgia is a chronic debilitating musculoskeletal pain syndrome that causes substantial physical and psychological impairments. the provisional criteria of the acr 2010 and the 2011 self-report modification for survey and clinical research are widely used for fibromyalgia diagnosis. however, there is no chinese version of fibromyalgia diagnosis criteria and severity assessment scales until now. the aim of this study is to investigate the reliability and the validity of the chinese version of the 2011modcr and 2016 acr revisions to the 2011modcr, as well as its quantification scale, the chinese version of fibromyalgia impact questionnaire (fiq-c) and revised fiq (fiqr-c). in this study, we'll divide patients with chronic pain without psychiatric disorders other than depression into two groups according to the 1990 acr diagnostic criteria for fibromyalgia, a fibromyalgia group and a non-fibromyalgia group. patients in both groups will be assessed using the 2011modcr and 2016 acr revisions to the 2011modcr. furthermore, those in the fibromyalgia group will also complete fiq-c, fiqr-c and several other validated questionnaires including the medical outcome survey short form-36 (sf-36), the beck depression inventory (bdi), ect.

Eligibility criteria:
inclusion criteria: * age 18 years or older. * fulfills the american college of rheumatology (acr) 1990 classification criteria for fibromyalgia. exclusion criteria: * without any psychiatric disorders other than depression.
epidemiology of osteoarthritis (oa) pain

Conditions: Osteoarthritis

Summary: chronic pain, by definition, persists over long periods of time, but both sufferers of pain and their caregivers are aware that pain levels can fluctuate greatly over time. being able to define pain variability and its underlying causes would be an important advance in our understanding of chronic pain, and would in turn lead to better approaches to the treatment of chronic pain. in this study, the investigators propose to evaluate in 60 people with chronic pain of the knee due to osteoarthritis over 3 months, collecting data regarding magnitude of pain, physical activity level, and medication status twice daily during this period of time. the investigators then will assess the variability in pain levels over time, the frequency of "flares" of osteoarthritis (oa) pain and their relationship to physical activity, medications, and clinical descriptors of the population, e.g., age, gender, body mass index (bmi). additionally, evaluations will be made regarding temporal patterns of oa knee pain as well as assessment of subgroups of patients with the overall group being studied.


Eligibility criteria:
inclusion criteria: 1. men and women, age 40 years and above 2. knee pain most days of the week for the past month 3. diagnosis of knee oa 4. meet acr criteria for knee oa 5. no significant limitations in physical activity 6. own and able to use a cellular phone capable of text messaging 7. able to return for all clinic visits 8. able to read and understand the informed consent document exclusion criteria: 1. use of a walker to ambulate or inability to ambulate (use of cane is allowed) 2. other forms of arthritis 3. other major causes of pain that could be expected to interfere with assessment of pain during this trial, e.g., recurrent migraine, back pain, fibromyalgia 4. scheduled for and likely to need joint replacement surgery in the next 3 months 5. any medical condition that in the judgment of the investigator would make the participant not suitable for the study 6. living in a long-term care facility

Keywords: oa osteoarthritis pain variability activity treatment