Kornimate/medical-research-clean huggingface dataset:
effectiveness study of the boa(r)-constricting iv band

Conditions: Catheterization, Peripheral

Summary: the purpose of this study is to determine whether the boa(r)-constricting iv band is superior to standard methods for starting an iv.

we will test the hypothesis that paramedics and nurses treating in- and out-of-hospital patients with a boa(r)-constricting iv band, compared to paramedics using standard treatment, will have better success rates for peripheral iv access.

Eligibility criteria:
inclusion criteria: * paramedics employed by the city of houston or nurses employed by memorial hermann hospital - texas medical center * agree to participate through written consent process exclusion criteria: * city of houston paramedics and memorial hermann hospital - texas medical center nurses who do not provide written informed consent to participate

Keywords: catheterization, peripheral disposable equipment emergency medical technicians emergency nursing
habitual and neurocognitive processes in adolescent obesity prevention

Conditions: Obesity; Behavioral Intervention; Obesity Prevention; Diet; Adolescents

Summary: the study tested an intervention that used a cue-removal and implementation intentions based strategy to change habitual dietary behaviors. the intervention was evaluated using a randomized experimental design that consisted of two conditions including (1) a control condition or (2) a cue and implementation intention-based intervention. high schools (n=22) were randomly assigned to one of the two conditions. families (n=187), with a family defined as an adolescent and one participating parent, were recruited from within the 22 schools. all of the families from each school were assigned to the same condition. families that were eligible for the study and that were interested in participating scheduled an appointment to complete informed consent. after written parental consent and youth assent was obtained, the participants had their height and weight measured and completed a series of questionnaires programmed on laptops. in addition, the adolescent took part in a 24 hour dietary recall assessment. the family was also informed that a second 24 hour dietary recall assessment would be administered to the adolescent over the phone in approximately 3-14 days. families that were from a school assigned to the control condition received an intervention on sun safety that consisted of a 10-minute meeting with a trained health coach, two generic newsletters, an email, and a text message. families from a school assigned to the cue- and implementation intentions condition received an intervention on healthy snacking and the reduction of sugar sweetened beverage consumption that consisted of a 90-minute meeting with a trained health coach, two 20-minute phone calls, four tailored newsletters, and a series of emails and text messages. both of these interventions were delivered over a period of 3-10 weeks depending on the self-directed pace of the participants. all participants were then asked to complete a follow-up assessment appointment three months after their original consenting appointment. our hypotheses focused on dietary behaviors and stated that adolescents assigned to the cue-removal and implementation intentions intervention would consume significantly fewer daily servings of high fat snacks, high sugar snacks, and sugar sweetened beverages than adolescents in the control condition.

see above.

Eligibility criteria:
inclusion criteria: * eligibility criteria for adolescents included being english-speaking, * between the ages of 14 and 17, * free of major illness, * not receiving clinical treatment for obesity, * possessing a cell phone with text messaging capability. exclusion criteria: * failure to meet inclusion criteria
effect of probiotics on the intestinal microbiota of pediatric patients

Conditions: Neurodevelopmental Disorders

Summary: numerous studies have described an altered gut microbiota composition (dysbiosis) in patients with neurodevelopmental disorders that can be correlated with their symptoms, especially gastrointestinal symptoms. an interventional, randomised, double-blind, placebo-controlled study will be conducted to investigate the effect of a probiotic supplement on the microbiota composition of children aged 3-7 years with neurodevelopmental issues. the duration of the study will be of 6 months approximately, including 6 months of product intake. participants will be randomly assigned to one of the two study groups: control group with placebo administration or probiotic administration group.


Eligibility criteria:
inclusion criteria: * children aged 3 to 7 years old. * diagnosed with autism spectrum disorder, according to the clinical criteria of the "diagnostic and statistical manual of mental disorders, fifth edition (dsm-5)" and who meet criteria for asd according to the ados-2 classification. * presenting one or more gastrointestinal symptoms (constipation, diarrhoea, abnormal stools, painful defecation, abdominal pain, reflux, bloating, flatulence). * written informed consent signed by the parent or legal guardian with express or tacit consent of the other parent. exclusion criteria: * with intake of antibiotics in the last month. * with intake of probiotics in the last two weeks. * diagnosed with short bowel syndrome or has undergone relevant surgery on the gastrointestinal tract. * exhibiting a defect in the intestinal epithelial barrier (e.g. inflammatory bowel disease (ibd)). * diagnosed with endocrinological diseases such as diabetes mellitus, hypo- and hyperthyroidism, cushing's disease, addison's disease, etc. * having heart failure and a cardiac medical history (e.g. artificial heart valve, medical history of infective endocarditis, rheumatic fever, or cardiac malformation). * congenital or acquired immunodeficiency. * immunocompromised (e.g., cancer and/or transplant patients taking certain immunosuppressive drugs, patients with inherited diseases that affect or may affect the immune system). * uncertainty on the part of the investigator about the willingness or ability of the minor's parents or legal guardian to comply with the requirements of the protocol. * with oral hyper sensitivity impairments that prevent the uptake of the study product.
safety and efficacy of arterial delivery of autologous bone marrow cells in the treatment of insulin-dependent diabetes

Conditions: Type 1 Diabetes Mellitus

Summary: diabetes mellitus is a long-term multi-organ disease with severe implications that constitute a major health problem worldwide. type 1 diabetes is an autoimmune disorder in which the body's own immune system attacks and destroys the cells that make insulin. exogenous administration of insulin is the primary method of controlling type 1 diabetes by regulating blood glucose levels, but this treatment does not reverse nor prevent disease progression. our hypothesis is that when implanting stimulated total bone marrow by arterial injection directly into the pancreas, we will achieve functional recovery of insulin-producing cells. this study will include patients with chronic type 1 diabetes and absence of lesions in target organs. we will follow the evolution of patients receiving autologous total bone marrow implantation by selective catheterization and compare to a non-treatment control group. all subjects will continue to use insulin therapy as needed to maintain the best possible glucose control. the objective is to achieve a significant increase in c-peptide levels indicating a regeneration of the beta islet cells with a decrease in exogenous insulin usage in at least 70% of the patients. this study is a follow-up to our initial study in which 22 patients received autologous total bone marrow. the initial study was 100% safe but additional studies like the one described above are needed to show efficacy.


Eligibility criteria:
inclusion criteria: * between 18-30 years of age, diagnosed with diabetes mellitus type 1 (insulin-dependent). * negative antibody titers for gad and anti-islet. * measurements of serum c-peptide below normal values. * bmi 20-25, men, 19-24, women exclusion criteria: * diabetes type 2, gestational diabetes, and other types of secondary diabetes. * patients with acute metabolic complications of diabetes such as ketoacidosis at least within the last 6 months. * abdominal perimeter \>102 cm in men; \>88cm in women * fasting glycemia \>100 mg/dl, triglycerides \>150 mg/dl, hdl \< 40 mg/dl. * blood pressure: sbp \>135 mmhg and dbp \>85 mmhg at the time of randomization * patients with bmi \> 25 for men and \>24 for women. * patients weighing \< 40 kg. * patients with abnormal ecg indicative of acute or chronic ischemia or acute/chronic necrosis. * patients with anemias of any origin. * patients undergoing antibiotic treatment for acute infection. * patients with any blood abnormality. * patients with history of moderate to severe pancreatitis. * a female subject who is breast-feeding, pregnant, intends to become pregnant or refuses to use a contraceptive method during the course of the study. * patients allergic to iodine or filgrastim. * patients using medications that could affect this study. * patients with serious mental conditions. * patients who have undergone a previous stem cell treatment. * patients who do not accept and sign the informed consent.

Keywords: diabetes type 1 adult stem cells local injection catheter delivery bone marrow
effectiveness of the farsi diabetes self-management education (fdsme) program for people with type 2 diabetes

Conditions: Type 2 Diabetes Mellitus

Summary: to evaluate the effectiveness of the farsi diabetes self-management education program on psychosocial, lifestyle, and clinical measures in people with newly diagnosed people with type 2 diabetes and those with already-diagnosed type two diabetes who had received little self-management education. the development of the program was guided by an innovative process of intervention planning: intervention mapping.

for designing the management program, we will use intervention mapping (im) framework for systematically developing the theory and evidence based program. based on im approach, this study will have seven phases: step 1: needs assessment (development the problem analysis: health, quality of life, behavior, environment). step 2: we will develop proximal program objectives with a multidisciplinary expert panel of participants. step 3: after identification of the proximal program objectives, the next step will be to select theoretical methods and practical strategies based on evidence for alternative methods. step 4: the forth step of the program development will comprise of composing program materials and pre-testing these materials with a sample of patients at a diabetic outpatient clinic. step 5: by involving the future program facilitators (health care workers at outpatient clinics) a linkage system will be foreseen. step 6: planning for evaluation step 7: randomized clinical trial

Eligibility criteria:
inclusion criteria: * diagnosed with type 2 diabetes (according to the who criteria) * older than 18 years exclusion criteria: * pregnancy * unable to participate in a group program (for example, housebound or unable to communicate in farsi) * having reduced cognitive ability

Keywords: diabetes mellitus intervention studies program effectiveness
efficacy of platelet-rich plasma injection compare with corticosteroid in pes anserinus pain syndrome

Conditions: Pes Anserine Bursitis; Steroid Injection; PRP Injection

Summary: the goal of this research is to study the efficacy of treatment between prp injection and corticosteroid injection in patients with pes anserinus bursitis. the research question is whether prp can reduce pain more effectively than corticosteroids. the study is divided into two groups: one group receiving prp injections and the second group receiving corticosteroid injections. treatment outcomes will be monitored at four time points: baseline, 4 weeks, 12 weeks, and 24 weeks. the outcomes will be measured using the vas and womac scores.

randomization of patient with pes anserinus bursitis at opd od ramathibodi hospital. objective : to study the efficacy of treatment between prp injection and corticosteroid injection in patients with pes anserinus bursitis medhods : a randomized controlled trial , single blinded participants : patients with pes anserinus bursitis randomization : randomization will be performed using the software stata 16.0 (statacorp, college station, texas, usa). a various blocked randomization method interventions and control : * experimental groups : prp injection 4 ml * control groups : steroid injection , triamcinolone acetonide(40mg/ml) 1 ml + 1%lidocaine without adrenaline 3 ml = 4ml by orthopedic surgeon with ultrasound guide. allocation and concealment : a central randomization service will prepare sealed envelopes containing the assigned treatment for each patient. the envelopes will be kept in secure location until break the concealment at outpatient orthopedics department , ramathibodi hospital blinding : randomized controlled trial study, single blinded the assessor who will be follow up the patients, will be blinded to the group assignments. outcome measures: visual analogue scale (vas) , womac scores follow up: at 4 weeks, 12 weeks, and 24 weeks after injection. statistic analysis: stata 16.0, statacorp, college station, texas, usa analysis demographic data : mean, sd mean difference in patient-relevant outcomes : independent t- test

Eligibility criteria:
inclusion criteria * over 18 years old * patients diagnosed with pes anserine pain syndrome * patients willing to participate in the research project by signing a consent form exclusion criteria: * patients with a localized knee infection or a disseminated infection within the past 3 months * patients with thyroid disorders, rheumatoid arthritis, or other types of knee arthritis * patients with abnormal blood coagulation or thrombocytopenia * patients who are pregnant * patients with any type of cancer * patients who cannot follow up with treatment until the end of the project * patients who are unwilling to participate in the project or wish to withdraw from the research project

Keywords: pes anserine bursitis steroid injection prp injection
sustainable east africa research in community health

Conditions: HIV; Tuberculosis; Hypertension; Diabetes; Maternal Child Health; Cost Effectiveness

Summary: the search study aims to test evidenced-based innovative community based interventions that lead to the elimination of hiv in rural communities in east africa using a multi-disease approach. the first phase of the study will quantify the impact of early hiv diagnosis using a streamlined and immediate art (antiretroviral therapy). the second phase of the study, will quantify the impact of targeted pre-exposure prophylaxis (prep) in the context of universal treatment and streamlined care. the study intervention is designed to improve the entire continuum of care, to reduce structural barriers for all populations including those most "at risk".

the search study aims to test evidenced-based innovative community based interventions that lead to the elimination of hiv in rural communities in east africa using a multi-disease approach. the first phase of the study will quantify the impact of early hiv diagnosis using a streamlined and immediate art (antiretroviral therapy). the second phase of the study, will quantify the impact of targeted pre-exposure prophylaxis (prep) in the context of universal treatment and streamlined care. the study intervention is designed to improve the entire continuum of care, to reduce structural barriers for all populations including those most "at risk".

Eligibility criteria:
community level inclusion criteria: * non-adjacent geopolitical units in south-western and eastern uganda and western kenya. * most recent census population between 9,000 and 11,000 individuals. * served by an art providing health center. * community leader commitment for study participation and implementation. * accessibility to health center via a maintained transportation route. * community location with sufficient distance from other potential study communities to limit contamination of intervention or control conditions (buffer zone) individual level inclusion criteria: * residency of individual in community, defined as present in household for at least 6 months of the calendar year. community level exclusion criteria: * presence of ongoing community-based art intervention strategies that provide treatment outside of the current in-country treatment guidelines. * an urban setting defined as a city with a population of 100,000 or more inhabitants. * absence of a health center able to provide art.

Keywords: hiv treatment and prevention tuberculosis community health campaign prep
effect of theophylline in pseudohypoparathyroidism

Conditions: PHP Ia; PHP IB; Php1C

Summary: the study evaluates the effect of theophylline in 100 subjects with pseudohypoparathyroidism.

it is an open label intervention study for the off-label use of theophylline in psuedohypoparathyroidism (php).theophylline is a is non-specific phosphodiesterase inhibitor which increases the levels of secondary messenger,camp. php patients have end organ resistance to hormones involving camp signaling. thus, theophylline has a potential to abrogate hormone resistance. also, it may have a role in bone maturation, neurocognition and metabolism.

Eligibility criteria:
inclusion criteria: * subjects with known diagnosis of php1a and php1b * age \>5 years exclusion criteria: * • significant kidney disease, i.e. any ckd stage * hypercalciuria * kidney stones * severe heart disease * uncontrolled seizure disorder * peptic ulcer * liver dysfunction * bleeding disorder * allergy to theophylline preparation * muscle disorder * infection * any neurologic disease * chronic drugs interacting with theophylline

Keywords: php
improving dosing of vancomycin in young infants with infections

Conditions: Sepsis; Infection; Bacteremia

Summary: current dosing regimens for vancomycin result in many young infants not reaching the target level of vancomycin in the blood at steady state (when the blood is in equilibrium at 24-48 hours).the purpose of this study is to assess an improved method of calculating the dose of vancomycin ('model-based dosing') in young infants with infections in order for them to achieve the target vancomycin level at steady state. a dosing calculator (which will be available through a web application) will be used for the dose calculation.

standard of care dosing of vancomycin in young infants is based on weight (eg. 15 mg/kg/dose). there is evidence that many young infants who are prescribed vancomycin using this calculation will not have enough vancomycin in the blood at steady state to treat an infection effectively. in this study a dosing calculator will be used to generate each participant's dose with the aim to improve the number of participant's who achieve the target vancomycin level (10 - 20 mg/l) at steady state. the dosing calculator is based on a pharmacokinetic/pharmacodynamic model of vancomycin which was built from prospective data. the participant's weight, post-menstrual age, creatinine and target vancomycin level will be entered into the dosing calculator (available on a web application), and the calculator will provide the dosing regimen for that participant. the participant will have the vancomycin level checked at 24-48 hours to assess if the target level has been achieved. this study is 'part 1' of the study protocol (version 4.0) as approved under hrec reference number hrec/51942/rchm-2019. this protocol also includes a second study, 'part 2', which will be registered with clinicaltrials.gov separately. part 2 will assess the use of early drug monitoring and early dose adjustment to achieve the target vancomycin level in the blood at steady state. part 1 of this protocol will be completed before part 2 begins recruitment. part 1 and part 2 are two separate studies and the results of each part will not be compared to one another. however, each part will be compared to a retrospective control arm - infants from the vanc randomized controlled trial (nct02210169) who received standard intermittent infusion of vancomycin dosing (as per british national formulary for children. 15mg/kg/dose) and standard therapeutic drug monitoring.

Eligibility criteria:
inclusion criteria: * infants aged 0 - 90 days old * suspected infection requiring treatment with vancomycin for 48 hours or more (as determined by the clinical team) * post-menstrual age (pma) matched to pma-group from retrospective control group exclusion criteria: * infants with corrected gestational age of less than 25 weeks * infants weighing less than 500g * known allergy to any glycopeptide antibiotic * vancomycin administered within the previous 72 hours * infants receiving any form of extracorporeal life support * renal impairment * previously enrolled in the study
contribution of icg angiography in the detection of parathyroids and the prevention of hypoparathyroidism post total thyroidectomy

Conditions: Thyroid Diseases

Summary: * hypoparathyroidism is the most common complication after a total thyroidectomy surgery. it becomes permanent after 6 months. * untreated permanent hypoparathyroidism is a source of numerous complications in general and therefore requires lifelong replacement therapy resulting in a significant deterioration in quality of life. * the intraoperative use of indocyanine green (icg) angiography has recently been described as a reliable means of detecting parathyroidism and predicting the risk of postoperative hypoparathyroidism. * this use could prove to be a way to preserve parathyroid in vivo and thus reduce post-operative hypoparathyroidism rates.

hypoparathyroidism is the most common complication after a total thyroidectomy surgery. it is most often transient but can sometimes be permanent when it persists for more than 6 months after surgery. the rates are variable, of the order of 32% for transient hypoparathyroidism and 1% for definitive hypoparathyroidism. untreated permanent hypoparathyroidism is the source of many complications in general and therefore requires lifelong replacement therapy. the result is a significant deterioration in quality of life. the mechanisms responsible for hypoparathyroidism during thyroidectomy are direct damage to the parathyroid glands, involuntary excision of these glands, and devascularization of these glands. the detection of parathyroid glands and the prevention of hypoparathyroidism after thyroidectomy therefore represents a major challenge. the intraoperative use of indocyanine green angiography has recently been described as a reliable means of detecting parathyroid and predicting the risk of postoperative hypoparathyroidism. in addition, prior studies and intraoperative observations suggest that indocyanine green angiography during thyroid surgery may be a means of preserving parathyroid in vivo and thus reducing post-operative hypoparathyroidism rates.

Eligibility criteria:
inclusion criteria: * patient having to undergo a total thyroidectomy * signed consent * patient beneficiary of a social security regimen exclusion criteria: * minor patient under 18 years old * major patient protected by law or unable to give informed consent * pregnant or breastfeeding woman * thyroidectomy totalization * history of thyroid or parathyroid surgery * participation refusal * known allergy to icg * woman of child-bearing age not using adequate method of contraception

Keywords: hypocalcemia hypoparathyroidism angiography