Kornimate/medical-research-clean huggingface dataset:
glycemic control and retinal microvascular changes

Conditions: Diabetic Retinopathy; Neurodegeneration; Blood Sugar; High

Summary: the goal of this prospective, observational study is to compare in the association of glycemic control and retinal microvascular changes in patients with type 2 diabetes mellitus (t2dm) without diabetic retinopathy (dr). the main question it aims to answer are: • do degenerative changes in retinal microvasculature or nerves depend on glycemic control even before diabetic retinopathy is detected? participants will receive an annual routine comprehensive examination including ultra-widefield fundus photography, spectral domain optical coherence tomography (oct), and swept-source optical coherence tomography angiography (octa).


Eligibility criteria:
inclusion criteria: * the study included 30-70-year-old patients with t2dm without known dr at baseline who underwent regular screening for dr at the department of ophthalmology. * who underwent regular checkups for dr between january 2019 and august 2022 at dongguk university ilsan hospital. * the controls included patients without dm who presented for regular ophthalmic examination. exclusion criteria: * patients with a history of retinal or choroidal diseases (i.e., age-related macular degeneration, retinal vein occlusion, uveitis, retinal detachment, and central serous chorioretinopathy), glaucoma, or optic neuropathy * patients with neurodegenerative diseases, such as parkinson's disease and dementia.
comparative research among 3 action protocol in other to approach chronic patellar tendinopathy

Conditions: Tendinopathy

Summary: the accomplishment of a treatment with intratissue percutaneous electrolysis of additional form to the accomplishment of eccentric exercise's program in patients with chronic patellar tendinopathy is more effective than the accomplishment of an additional treatment with dry needling or eccentric exercise's program realized of isolated form.

experimental study randomized with double blind, whose purpose is to compare three protocols in those who apply different protocols of physical therapy to themselves in three groups of intervention with patients with chronic patellar tendinopathy. there take part in this study young women of both sexes, of zaragoza and of different sports clubs of entity 18 and 40 years, that they realize of habitual form (minimum 3 times a week) a sport. all of them present chronic patellar tendinopathy.

Eligibility criteria:
inclusion criteria: * age understood between 18 and 40 years. * to practise any sport of habitual form. * patients diagnosed of chronic patellar tendinopathy with a minimum of 3 months of evolution and with stable symptomatology. * pain to the palpation of the tendon in the low pole of the knee and during the training or competition. * punctuation of the questionnaire visa-p under 80. exclusion criteria: * patient had an operation on the knee affected in the last 6 months. * infiltrations in the knee affected in the last 3 months. * patient who has received pharmacological treatment or physical therapy in the last 48 hours. * pathology with less than 3 months of evolution. * to present bilateral chronic tendinopathy. * punctuation of the questionnaire major or equal visa - p of 80. * inability to apply someone of the techniques of treatment or valuation for absolute or relative contraindication.

Keywords: intratissue percutaneous electrolysis dry needling eccentric exercise patella
ern reconnet study on covid-19 vaccination in rare and complex connective tissue disease (vaccinate)

Conditions: Connective Tissue Diseases; Rare Diseases; Rheumatologic Disorder

Summary: 30 months, multicentre, prospective observational study on adult (\>18 years) patients with a diagnosis of rare and complex connective tissue diseases (rctds) who will be given the vaccine during the period from january 2021 and january 2022. patients with the following diagnosis will be included: * antiphospholipid syndrome (aps), * ehlers-danlos syndrome (eds), * idiopathic inflammatory myopathies (iim), * igg4-related disease (igg4), * mixed connective tissue disease (mctd), * relapsing polychondritis (rp), * sjogren's syndrome (ss), * systemic lupus erythematosus (sle), * systemic sclerosis (ssc) * undifferentiated connective tissue disease (uctd)

this is an observational study aimed at gathering sufficient number of cases of rctds patients who will receive covid-19 vaccination that will help in better understanding of both safety and efficacy of the vaccine in this population. the study will be promoted both in ern reconnet full members and affiliated partners as well as in other centres treating and managing rare and complex connective tissue diseases. study objectives 1. to promote a harmonised data collection approach on covid-19 vaccination in rare and complex ctds patients; 2. to evaluate the safety profile of covid-19 vaccination in rctds patients and to highlight possible disease-specific adverse events; 3. to evaluate the efficacy of covid-19 vaccination in rctds patients and to highlight potential variables that prevent an effective immunization against covid-19; 4. to evaluate differences in term of efficacy and safety among different types of vaccines in rctds patients 5. to depict the ideal patient's profile that would mostly benefit from covid-19 vaccination

Eligibility criteria:
inclusion criteria: patients with the following diagnosis will be included: * antiphospholipid syndrome (aps), * ehlers-danlos syndrome (eds), * idiopathic inflammatory myopathies (iim), * igg4-related disease (igg4), * mixed connective tissue disease (mctd), * relapsing polychondritis (rp), * sjogren's syndrome (ss), * systemic lupus erythematosus (sle), * systemic sclerosis (ssc) * undifferentiated connective tissue disease (uctd) exclusion criteria: * pregnancy * all the exclusion criteria that apply for covid-19 vaccination in the general population
effects of pediatric endurance and limb strengthening (pedals) program vs task-oriented training (tot) improving gross motor function in children with cerebral palsy

Conditions: Cerebral Palsy

Summary: to compare the effects of pediatric endurance and limb strengthening (pedals) program vs task-oriented training (tot) improving gross motor function among children with cerebral palsy.

by integrating the pediatric endurance and limb strengthening (pedals) exercises and task oriented training children can engage in more comprehensive therapy that simultaneously targets muscle strengthening, coordination and balance with in a context that stimulates real life activities. task oriented training interventions can promote neural plasticity through repetitive task specific practice. it will have marked impact on improvement of adls in cp community. this study will play a vital role in improving the mobility of cp community. hence improving the gross motor functions i.e. facilitating the cp child being more independent in sitting standing jumping and running.

Eligibility criteria:
inclusion criteria: * • diplegic cerebral palsy children * gross motor classification system level 1and level 2. * age 6 to 12 years. * male and female are included. exclusion criteria: * • individuals with co-existing medical conditions that significantly impact motor function other than cp. * participants who are unable to engage in the assigned interventions due to physical or cognitive limitations. * gross motor classification system level 3.4 and 5. * any contraindications to the assigned interventions, such as severe motion sickness or contraindications to physical exercise for pedal training. * previous participation in similar interventions within a defined timeframe to avoid potential confounding effects.

Keywords: task-oriented training (tot) pediatric endurance and limb strengthening (pedals) gross motor function (gmf)
the effects of whey, rice and potato protein isolates on appetite regulation in healthy men

Conditions: Appetite and General Nutritional Disorders

Summary: introduction: global protein consumption has been increasing for decades due to changes in socio-economic demographics and consumer trends towards higher protein intake, which may be related to their health benefits in performance nutrition and appetite regulation. the additional intake of protein often occurs in the form of supplements. one of the main ingredients used in sports and weight loss supplements are animal-derived proteins such as whey, which are of high quality, containing all the essential amino acids required in human nutrition with a high absorption rate. however, whey protein has a high environmental footprint, and it may contribute to insulin resistance in susceptible groups (e.g. obese, t2dm, insulin resistant, or those with sarcopenic obesity). rice and potato protein isolates are high-quality plant proteins containing all essential amino acids comparably to whey protein. these plant-derived proteins may provide a more sustainable and accessible alternative to animal-derived proteins for appetite regulation and weight management.

intervention study with three treatment groups in a randomised, single-blind, triple crossover design. study population: healthy male participants will receive three different isocaloric and -volumetric protein shakes prepared using whey, rice and potato protein powders on different trial days with at least a one-week washout period apart. biological samples (blood and saliva samples) are collected at various time points during the visit. blood samples are collected at baseline 10 min prior (t-10), then at 30 min (t30), 60 min (t60), 120 min (t120) and at 180 min (t180) after protein shake consumption. saliva samples are collected at baseline (t-10), then at every 30 minutes following protein shake consumption (t30, t60, t90, t120, t150, t180). in addition, pertinent questionnaires visual analogue scale \[vas\] for the assessment of satiety and vas for the assessment of protein shakes' perception will be collected at t-10, t30, t60, t90, t120, t150, t180 and at t0, respectively

Eligibility criteria:
inclusion criteria: * males (18-65 years of age) * healthy subjects exclusion criteria: * \ 65 years * consumption of \>21 units of alcohol/week * dieters * any allergies/health issues related to items being ingested * any serious illnesses or those on medication * any illness affecting taste or appetite * any gastrointestinal disorders * any eating disorders * any depression/mental disorders * smoking

Keywords: nutraceutical protein whey potato protein rice protein appetite satiety insulin glucose appetite hormone glp-1 pyy supplement
an open trial of duloxetine on comorbid major depression and chronic headache

Conditions: Major Depression; Chronic Primary Headache

Summary: background: although major depression and chronic headache are strongly associated, there is insufficient evidence on the use of antidepressants for this specific comorbidity. this trial aimed to investigate the efficiency and tolerability of duloxetine for this indication. methods: thirty outpatients of our clinic, with dsm-iv major depression and concurrent primary chronic headache (chronic migraine, chronic tension-type headache or both), 18-55 years, were recruited from april 2006 to march 2007, if they scored \>21 on the montgomery-äsberg depression scale (madrs) and had no other significant clinical condition. subjects received duloxetine 60 mg/day for 8 weeks. madrs scores and a visual analog pain scale (vas) were the co-primary outcome measures. who quality of life scale (whoqol bref) scores and headache days/week were secondary outcome measures.conclusion: in this preliminary open trial, duloxetine 60 mg/day was effective, fast acting and well tolerated for the treatment of comorbid major depression and chronic headache.


Eligibility criteria:
inclusion criteria: * major depression (according to dsm-iv criteria) * madrs scores superior to 21 * subjects meeting the international headache society criteria for chronic primary headache (ihsc-2 codes 1.5.1, 1.6.1, 2.3.1, 2.3.2 and 2.4.3) (ichs, 2003) exclusion criteria: * over 50% reduction on madrs scores during wash-out period * illicit drug or alcohol dependence * history of multiple allergies or hypersensitivity to duloxetine * history of epilepsy or significant neurological disorder * significant suicide risk * pregnancy or lactation * sexually active female subjects not using an efficient contraceptive method * significant laboratory abnormalities at baseline * significant clinical disease * subjects meeting dsm-iv criteria for somatisation disorder. (300.81) or presenting with delusional pain symptoms.

Keywords: major depression chronic headache antidepressant duloxetine
watermelon and beetroot products on endothelial function

Conditions: Healthy Young; Older People With Cardiovascular Disease Risk

Summary: cardiovascular disease is the main cause of death worldwide. endothelial dysfunction is the first step to development of cardiovascular diseases. endothelial dysfunction occurs due to reduction in nitric oxide, a molecule that plays an important role on vascular health. due to important role of nitric oxide in endothelial function, several studies have evaluated the effect of its precursors, such as l-citrulline and nitrate on endothelial function parameters. the present study will evaluate the effect of l-citrulline and nitrate derived by watermelon and beetroot products, respectively, on endothelial function of young and older participants. furthermore, we will evaluate the plasmatic amino acids, nitrate, glucose and insulin in response to ingestion of these products.


Eligibility criteria:
inclusion criteria for healthy young participants: * age between 18-35 years; * triglycerides ≤ 150 mg/dl * hdl-cholesterol ≥ 50 mg/dl for women and ≥ 40 mg/dl for men; * waist circumference ≤ 102 cm for men and ≤ 88 cm for women). inclusion criteria for older people with cardiovascular risk: * age ≥ 60 years; * elevated triglycerides ≥150 mg/dl; * reduced hdl-cholesterol ≤ 50 mg/dl for women and ≤ 40 mg/dl for men; * elevated waist circumference ≥102 cm for men and ≥ 88 cm for women). exclusion criteria: * elevated fasting glucose (≥100 mg/dl); * smoking; * beetroot or watermelon allergy; * unwillingness to avoid beetroot or watermelon products during the entire study; * other chronic diseases (diabetes, liver disease, etc.) or acutely ill

Keywords: endothelial function l-citrulline nitrate nitric oxide
sars-cov-2 seroprevalence among nursing home staff and residents (covid-19)

Conditions: Covid19; SARS-CoV-2 Infection

Summary: assessment of the seroprevalence and sero-incidence of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) among nursing home (nh) residents and staff in belgium.

in this longitudinal cohort study, 3036, nursing home (nh) residents (1656) and staff (1380), spread over 69 nursing homes throughout belgium will be repeatedly sampled at a 2-month interval. seroprevalence and -incidence will be assessed by means of a point-of-care rapid antibody test with additional collection of a dry blood spot sample for quantitative detection of immune markers\*. sample collection (capillary blood samples) at baseline (day 0, week 0) will start in a staggered way, so all baseline samples among the different nursing homes are collected within the first 21 days after collection of the first sample. follow-up sample collection will occur with a 2-month interval in week 8, week 16, week 24, week 32 and week 40 after the baseline collection of that specific nursing home. at each timepoint, questionnaires will be taken concerning medical history, clinical outcomes and potential covid-19 riskfactors. the recruited nhs will be equally spread across the belgian territory according to geographic and demographic characteristics to guarantee general representativity. forty-four participants (20 staff, 24 residents) will be randomly included per nursing home. (\* collection of the dry blood spot is part of a sub-study by ghent university)

Eligibility criteria:
inclusion criteria: * residents and staff from belgian nursing homes exclusion criteria: * service flat residents * temporary staff, employed for a period of less then 1 year starting from baseline collection

Keywords: covid19 sars-cov-2 infection seroprevalence nursing home
liv001 in patients with mild-to-moderate active ulcerative colitis (uc)

Conditions: Ulcerative Colitis (UC)

Summary: a phase 1b study to evaluate the safety and tolerability of liv001 in patients with mild-to- moderate active ulcerative colitis

a randomized, double-blind, placebo-controlled, multi-center study to evaluate the safety and tolerability of liv001 in patients with mild to moderate uc. patients will receive liv001 or placebo for 8 weeks. all patients will return to the site for a follow-up visit on week 12.

Eligibility criteria:
inclusion criteria: 1. male or female aged 18 to 65 years (inclusive) at screening. 2. established diagnosis of uc for at least 3 months prior to screening, diagnosed by routine clinical, radiographic, endoscopic or pathologic criteria (confirmed by colonoscopy and pathology records or, if unavailable, diagnosis confirmed by a letter from the subject's general practitioner.) exclusion criteria: 1. possible or confirmed diagnosis of crohn's disease, other form of inflammatory bowel disorder and coeliac disease. 2. history of a condition associated with significant immunosuppression, or chronic administration (\> 14 consecutive days) of immunosuppressants or other immune-modifying drugs within 3 months prior to visit 3 (subjects taking oral medications for uc, including corticosteroids or immunomodulators, are not excluded).
the evaluation of external thermomechanical stimulation for pain reduction in patients undergoing nail injection

Conditions: Nail Diseases

Summary: the purpose of this study is to assess the efficacy and safety of a thermomechanical device delivering vibration and cold stimuli in lowering pain during intramatricial nail injections


Eligibility criteria:
inclusion criteria: * men and women aged 18 years or older * must understand and voluntarily sign an informed consent form * all patients undergoing intramatricial nail injections at the weill cornell medicine (wcm) department of dermatology * willingness to participate in the study exclusion criteria: * inability of the patient to provide written informed consent for any reason * failure to have nail injection performed * likely inability to comply with the study protocol or cooperate fully with the research team

Keywords: nails thermomechanical stimulation intralesional injection
hypnosis intervention for the management of pain perception during joint lavage

Conditions: Knee Osteoarthritis

Summary: the purpose of this study is to determine whether hypnosis intervention added to usual care is more effective than usual care alone to control pain during lavage procedure in patients with knee osteoarthrosis

joint lavage can be used in acute knee osteoarthritis, and can be repeated when it is effective. this procedure can generate pain and anxiety which are prevented by systematic prescription of analgesics and anxiolytics. to assess the benefit of hypnosis intervention, the investigators designed a monocentric prospective controlled randomised, single-blind study. patients with acute and painful knee osteoarthritis, having an indication of lavage according to the rheumatologist, will be randomized to standard care, versus standard care and hypnosis. the hypothesis is that hypnosis intervention will decrease the level of pain during lavage, and the analgesics consumption during the week following the lavage. the sample size will be 100, 50 patients per group. inclusion is scheduled for 18 months, and duration of the study will be 2 years. the main efficacy criterion is the pain score (assessed using vas) difference between the 2groups; no interim analysis will be performed.

Eligibility criteria:
inclusion criteria: * diagnosis of knee osteoarthritis * indication for a lavage exclusion criteria: * people who have had both knees washed on the same day. * people who have already received a joint lavage. * patients with psychotic disorders. * refusal to participate. * people who do not understand and/or speak french or who are deaf.

Keywords: hypnosis intervention analgesics knee osteoarthritis joint lavage
local anesthetic automated intermittent administration vs. continuous infusion via femoral nerve block.

Conditions: Postoperative Pain; Postoperative Complications

Summary: this study evaluates the impact of local anesthetic administration regiment through peri-neural femoral nerve catheter on pain and motor block frequency, after total knee arthroplasty.

this study evaluates the impact of local anesthetic administration regiment through peri-neural femoral nerve catheter on pain and motor block frequency, after total knee arthroplasty. one group of patients will receive automated intermittent bolus, while the others will get a continuous infusion. in both cases, patients will be able to administer supplementary auto-bolus if required.

Eligibility criteria:
inclusion criteria: * admitted for unilateral primary total knee arthroplasty. exclusion criteria: * asa score \> 3 * bmi \> 40 * refusal of loco-regional technique. * psychiatric disease. * inability to understand/ use the local anesthetic delivery pump. * local anesthetic allergy, * porphyry, * uncontrolled epilepsy, * severe cardiac arrhythmia.

Keywords: total knee arthroplasty postoperative pain programmed intermittent bolus continuous femoral nerve block
study of cpi-006 as immunotherapy for hospitalized covid-19 patients

Conditions: COVID-19

Summary: this phase 1 single-dose, dose-escalation study is an open label trial evaluating the safety of cpi-006, a humanized monoclonal antibody targeting the cd73 cell-surface ectonucleotidase, as immunotherapy for stable hospitalized mild or moderately symptomatic covid-19 patients with a parallel non-randomized control arm for treatment with standard of care only.


Eligibility criteria:
inclusion criteria: * nasal swab test positive by reverse transcriptase pcr for sars cov-2 within past 7 days, and onset of covid-19 symptoms no more than 10 days prior to the positive test * hospitalized and have stable mild to moderate symptoms of covid-19 * blood oxygen saturation of a minimum of 92% on either no oxygen or up to 5l/min supplemental oxygen * patients with cancer must be in remission or have stable, controlled disease and may be actively receiving drugs or biologics not deemed by the investigator to likely affect immune response. * women must not be of child bearing potential or agree to use contraceptive guidance for 6 weeks exclusion criteria: * patients receiving previous invasive mechanical ventilation or non-invasive ventilation (cpap, bipap) for covid-19 illness * patients hospitalized \>7 days prior to receiving study intervention * other diseases or conditions that are not controlled * on drugs or biologics that are immunosuppressive, cytotoxic or immunomodulatory * patients with autoimmune disease must be controlled on non immunosuppressive or immune modifying agents * have received cytotoxic, immunosuppressive or immunomodulatory agents within past 3 months (other than for treatment of covid-19). * patients receiving experimental therapies that are immunosuppressive * patients receiving non-immuno-suppressive experimental therapies within 7 days prior to receiving cpi-006 * patients receiving convalescent plasma within 24 hours prior to receiving cpi-006 * patients receiving experimental anti-sars cov-2 monoclonal antibodies within past 30 days

Keywords: sars cov-2 coronavirus covid