Kornimate/medical-research-clean huggingface dataset:
interferon for the intervention of molecular relapse in t (8; 21) aml after allo-hsct

Conditions: Acute Myeloid Leukemia

Summary: molecular relapse in t (8; 21) acute myeloid leukemia (aml) after allogeneic stem cell transplantation (allo-sct) is still a problem even after donor lymphocyte infusion. interferon seemed to augment graft-versus-leukemia (gvl) effect in this part of patients. the study is to evaluate the safety and efficacy of interferon for the intervention of molecular relapse in t (8; 21) acute myeloid leukemia (aml) after allogeneic stem cell transplantation (allo-sct)


Eligibility criteria:
inclusion criteria: * high risk t (8; 21) aml * molecular relapse after allo-sct exclusion criteria: * active graft-versus-host disease * uncontrolled severe infection * organ function failure
effects of stimulus validity on speech recognition

Conditions: Hearing Impaired

Summary: the effects of talker variability will be investigated with four groups of listeners (young normal-hearing; old normal-hearing; young hearing-impaired; old hearing-impaired). experimental conditions will include between-talker differences, speaking rate, lexical difficult and semantic/linguistic context. a preliminary experiment will evaluate the relative merit of adaptive vs fixed-level methods of stimulus presentation.


Eligibility criteria:
hearing impaired

Keywords: hearing loss, speech recognition
effects of therapeutic exercise on quality of life

Conditions: Physical Therapy; Health Promotion; Quality of Life

Summary: the main objective was to determine the efficacy and safety of a therapeutic exercise program for students. secondary objectives, determine the prevalence and intensity of musculoskeletal pain (msp), disability, health-related quality of life (hrqol), and satisfaction and perceived improvement with program.

methodology: randomized, controlled, open clinical trial. subjects were recruited from students of degree of physiotherapy. inclusion and exclusion criteria were established. physical component summary (pcs) of sf36, as primary outcomes, was taken to the sample size. randomization was single-blind. secondary response variables were measured through the nordic musculoskeletal questionnaire, visual analogue scale, oswestry disability index, neck disability index, trunk flexor endurance test and finger-floor distance test. an assessment pre and post intervention was performed. this consisted of a therapeutic exercise program based on the stabilization, 9 sessions of 1 hour. for statistical analysis, the shapiro-wilk test, student's t test or test mannwitney, the statistic (x2) chi-square or fisher's exact test were applied. the level of significance was taken as p \<0.05. information sheet and informed consent model was delivered.

Eligibility criteria:
inclusion criteria: * students taking a course of the physiotherapy degree * having enrolled in october 2014 * having given their informed consent. exclusion criteria: * not accepting to take part in the study, * not attending the initial evaluation sessions, * having any type of cardiovascular, neuromusculoskeletal or systemic diseases that restricted exercise participation.
cope - covid-19 in pregnancy and early childhood

Conditions: Sars-CoV2; Covid-19; Pregnancy Complications; Pregnancy Preterm; Pregnancy in Diabetic; Neonatal Infection

Summary: purpose: the emergence of a new coronavirus sars-cov-2 causing a novel infection in the human race resulting in a world-spanning pandemic came as a surprise and at a tremendous cost both for individual human lives as well as for the society and the health care sector. the knowledge on how this new infection affects both the mother and the unborn child as well as the outcomes for the mother and the child in the long run are unknown. what is known is based on case-reports and small case-series solely. both the coronaviruses causing middle east respiratory syndrome (mers) and severe acute respiratory syndrome (sars) can cause a threat to pregnant women and their offspring, which leads to the question whether this could be the case also for sars-cov-2. aims: to establish a biobank of biological material from infected as well as non-infected pregnant women and their offspring. to combine this biobank with swedish quality and health care registers, computerized patient charts and questionnaire data, enabling both short-term follow up, such as obstetric outcomes, as well as long-term outcomes both for mother and child. to study how the pandemic situation affects both the mother and her partner in their experience of pregnancy, childbirth, and early parenthood. design: a national swedish multicentre study. women are included when they have a positive test for sars-cov-2 or a clinical suspicion of coronavirus disease 2019 (covid-19) (covid-19 group). pregnant women without covid-19 symptoms will be included at their routine visits (screening group). blood samples and other biological material will be collected at different time-points. additional predictors and outcomes are collected from the swedish pregnancy register as well as obligatory swedish health registers. the biobank and its linkage to health registers through the swedish personal identification number will enable future research. child development will be followed during the first year of life by questionnaires to the parents. womens' and their partners' experience of childbirth and parenthood will be studied in form of questionnaires as well as in form of interviews. conclusion: this project will help obstetricians and neonatologists better recognize clinical manifestations of the virus, identify possible risk factors during pregnancy and tailor therapies alongside providing right level of surveillance and management during pregnancy, delivery, and child health care.


Eligibility criteria:
inclusion criteria: * pregnant women 18 years of age and above * attending routine antenatal visits at a participating hospital during the study period or are strongly suspicious of or diagnosed with covid-19 during pregnancy. * for the questionnaire part: language knowledge (swedish, english, arabic, somali) * for the interview part: swedish language knowledge exclusion criteria: • another language but selected ones

Keywords: sars-cov2 covid-19 pregnancy neonatal long-term follow-up complications
reproducibility of the measurement of the right portal vein diameter

Conditions: Intrauterine Growth Retardation (IUGR)

Summary: although routine ultrasound is offered during the third trimester of pregnancy, less than a quarter of newborns with intrauterine growth retardation (iugr) are suspected antenatally. the measurement of the right portal vein (rpv) diameter on the transverse abdominal view at the 32 weeks' scan may be a new a tool for detecting small-for-gestational-age (sga) at birth. the irregular and collapsed aspect of the right portal vein (rpv) on the third trimester ultrasound could be used for identifying hypoxemic and growth-restricted fetuses. however, to our knowledge, the only interoperator reproducibility study of this measurement was performed using the same stored images or datasets without performing a new examination. the main objective of this study is to assess the intra and interoperator reproducibility of the measurement of the right portal vein diameter at the routine third trimester ultrasound. the secondary objective is to quantify the interoperator reproducibility of the assessment of the aspect, normal or collapsed, of the right portal vein, using an evaluation grid. two referees will perform four successive measurements of the diameter of the right portal vein (rpv) during the same ultrasound examination at the third trimester. each operator will qualify the appearance of the right portal vein as normal or collapsed using an evaluation grid, and will independently performe a series of two measurements using the same method.


Eligibility criteria:
inclusion criteria: * women carrying a pregnancy from 30 weeks to 33 weeks either normal or with iugr, * patient without guardianship or curatorship or subordination, * patient benefiting from a social security scheme exclusion criteria: * presence of a fetal malformation, * multiple pregnancy, * premature rupture of membranes, * history of bariatric surgery, * body mass index (bmi)\> 30 kg / m2, * patient benefiting from enhanced protection, namely: minors, persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social establishment, adults under legal protection.

Keywords: small-for-gestational-age right portal vein third-trimester ultrasound intra and inter-operator reproducibility
pain management in outpatient urologic procedures

Conditions: Urologic Diseases

Summary: goal of this study is to evaluate how pain is controlled after outpatient urologic surgeries. patients will receive either opioid pain medication or non-opioid medication for pain control. a survey will be conducted at the post-operative appointment to evaluate for pain control.

patients will be approached in the pre-operative area prior to their outpatient urologic surgery. informed consent will be obtained at that time. patients will be instructed that they will receive a prescription for either opioid pain medication or non-opioid medication for after surgery. the opioid medication includes oxycodone, while the non-opioid includes ketoralac, a non-steroidal anti-inflammatory medication. subjects will be assigned randomly to either medication. standard of care after outpatient urologic surgery is either oxycodone or ketoralac, however there is no previous research on whether one is superior than the other. these drugs were chosen because they are the most commonly used medications after outpatient urologic surgery. the study team and patients will not be blinded to the treatment. they will also receive instructions for non-opioid pain management. if the patients require additional pain medication after surgery, they are instructed to call the provider's office for further evaluation and treatment. the patient's physician will prescribe further medication if warranted. the post-operative appointment is scheduled 2-3 weeks after surgery. at the post-operative appointment, patients will then be given a four question paper survey inquiring how well their pain was managed, how many pills were taken, if any additional non-opioid medications were taken for pain, and how the extra pills were disposed. other phi that will be collected includes patient's age, gender, past medical history, past surgical history, renal function, prior medications, and current surgery.

Eligibility criteria:
inclusion criteria: * outpatient urologic surgery * age 18 and over exclusion criteria: * renal dysfunction * non-english speaking * employees of organization
quartet™ bad oeynhausen trial

Conditions: Congestive Heart Failure; Cardiac Resynchronization Therapy

Summary: primary objective of this study is to evaluate whether the use of a quadripolar left ventricular (lv) electrode compared to a standard bipolar lv electrode leads to lower non-responder rates in patients undergoing cardiac resynchronization therapy (crt)


Eligibility criteria:
inclusion criteria: * indication for crt-d implantation according to current guidelines * ischemic cardiomyopathy (icm) or dilated cardiomyopathy (dcm) * sinus rhythm * nyha ii-iv * age ≥ 18 years * written informed consent to participate in the study exclusion criteria: * right bundle brunch block * valvular cardiomyopathy * patient receiving a non-transvenous lv electrode * known pregnancy * age \< 18 years * life expectancy \< 1 year * atrial fibrillation / atrial flutter at the time of enrolment * inability to provide informed consent * participation in another study with active therapeutic arm * regular follow-up in the study center within the first 6 months after implantation not guaranteed

Keywords: cardiac resynchronization therapy; heart failure, congestive
wsi based dl for diagnosing the iaslc grading system of lung adenocarcinoma

Conditions: Lung Adenocarcinoma; Whole Slide Image; IASLC Grading System; Artificial Intelligence

Summary: the purpose of this study is to evaluate the performance of a whole slide image based deep learning model for diagnosing the iaslc grading system in resected lung adenocarcinoma based on a multicenter prospective cohort.


Eligibility criteria:
inclusion criteria: 1. age ranging from 18-85 years old; 2. pathological confirmation of primary lung adenocarcinoma after surgery; 3. obtained written informed consent. exclusion criteria: 1. multiple lung lesions; 2. poor quality of whole slide images; 3. mucinous adenocarcinomas and variants; 4. participants who have received neoadjuvant therapy.
nova cold hands raynaud's disorder, a disease which results in decreased blood flow to the hands and feet.

Conditions: Raynaud's Disease

Summary: patients presenting to uic rheumatology clinic with raynaud's disorder and scleroderma will be asked to participate. 10 hands of patients with both raynaud's disorder and scleroderma will be studied. this research study is being done to better understand raynaud's disease and to assess the role of blood flow measurement in diagnosing the disorder, specifically, through data collected by an mri procedure called nova flow. nova is a blood flow measurement software system owned by the study's sponsor, vassol, inc.

the investigators propose to obtain volumetric flow data on 10 hands of patients with raynaud's disorder and scleroderma at uic rheumatology clinic and compare these results with previously established volumetric flow data for non-raynaud's patients. through this analysis, the invstigators will be able to better understand and correlate subjective and objective measures of both disease presentation and progression. collection of cross sectional data will allow us to better address the following questions is it possible to more precisely diagnose patients with raynaud's disorder based on nova analysis as well as clinical findings is it possible to stratify patients with raynaud's disorder into categories which may allow: i. prediction of disease course and prognosis ii. prediction of response to specific treatment modalities (vasodilators vs anti-coagulation vs surgical or chemical denervation) the investigators propose to collect measurements of disease severity as well as functional assessment of patients raynaud's and scleroderma in order to address the following questions c. does nova flow and volume data correlate with measures of raynaud's and scleroderma disease severity index d. does nova flow and volume data correlate with ot assessment of hand functionality.

Eligibility criteria:
inclusion criteria: * inclusionary criteria for this study will be patients with a diagnosis of raynaud's disease and scleroderma (per acr criteria for the diagnosis for systemic sclerosis) and age between 18-85. exclusion criteria: * exclusion criteria for raynaud's patients will include history of botox injection to the hands within 6 months, non-english speaking patients and those unable to understand informed consent, and the presence of confounding medical conditions preventing the patient from full participation.
observational cohort study of advanced non-small cell lung cancer (captra-lung)

Conditions: Advanced Non-small Cell Lung Cancer

Summary: investigators propose to establish and maintain a cohort of patients with advanced non-small cell lung cancer, and to assess the treatment pattern, host genetic, and clinical factors which influence the prognosis and survival, as well as the interaction among these factors on disease diagnosis and treatment, short and long-term outcomes. study type: observational (patient registry) study design: observational model: cohort time perspective: prospective and retrospective


Eligibility criteria:
inclusion criteria: * cohort i: diagnosis of advanced non-small cell lung cancer from 2012-2016; * cohort ii: documented positive driver gene mutations; and diagnosis of advanced non-small cell lung cancer; * cohort iii: diagnosis of advanced non-small cell lung cancer and in immune-therapy; * cohort iv: diagnosis of advanced non-small cell lung cancer, and with wild-type driver gene or unknown driver gene status; * cohort v: treated with anti-vegf drug in first line, diagnosis of advanced non-squamous and non-small cell lung cancer in 6 months before recruit; * age\>18 years; * provision of written informed consent. exclusion criteria: * not applicable

Keywords: advanced non-small cell lung cancer
effectiveness of pre-emptive analgesics on post-operative pain after stainless steel crown placement on primary molars

Conditions: Post-operative Pain

Summary: the aim of this study is to evaluate the effectiveness of pre-emptive analgesia using ibuprofen and paracetamol on reducing post-operative pain following the placement of stainless steel crowns on primary molars compared to placebo

the study will be a parallel, placebo-controlled, triple-blinded, randomized clinical trial. a total of 66 healthy children aged 5-8 years requiring the placement of a stainless steel crown will be selected from pediatric dentistry and dental public health department, faculty of dentistry, alexandria university, egypt. the children will be randomly allocated into three groups according to the type of pre-emptive solution used. group i will receive ibuprofen, group ii will receive paracetamol, while group iii (control) will receive a placebo solution. children will self-report their level of pain using a visual analogue scale (vas) and/or a facial pain scale (fps) after local anesthesia administration, immediately after the cementation of the stainless steel crown, and 2, 6 and 24 hours post-operatively. children's baseline anxiety and parental anxiety will also be assessed.

Eligibility criteria:
inclusion criteria: participant inclusion criteria: * age range 5 to 8 years old * children without any previous interventional dental experience * children free of any systemic disease or special health care needs (asa 1) * children free of any allergies or hypersensitivity reactions to local anesthetics or analgesic drugs * positive or definitely positive behaviour during preoperative assessments according to the frankl rating scale (score 3 or 4) * parents/caregivers and children who are willing to participate in the study tooth inclusion criteria: * maxillary first or second primary molar teeth with extensive and/or multisurface caries where other restorations are likely to fail but without pulp exposure * absence of clinical and radiographic signs or symptoms of irreversible pulpitis * absence of fistula or abscess near the selected tooth clinically and radiographically * absence of spontaneous pain * absence of pulp exposure * absence of pathological mobility by placing the points of a pair of tweezers in an occlusal fossa, and gently rocking the tooth bucco-lingually

Keywords: pre-emptive analgesia ibuprofen paracetamol post-operative pain stainless steel crown primary molars
efficacy and time dependent effects of tdcs combined with mt for rehabilitation after subacute and chronic stroke

Conditions: Cerebrovascular Accident

Summary: this project is designed to investigate the intervention effects and time dependent effects of combining tdcs and mt in patients with subacute and chronic stroke.

this project is also designed to investigate the optimal application timing of tdcs in combination with mt in patients with subacute and chronic stroke. patients with subacute and chronic stroke will be recruited and randomized into one of the 3 groups: sequentially apply tdcs and mt group (seq), apply tdcs concurrently with mt group (con), and mt with sham tdcs group (sham). all participants will receive 40 minutes of mt followed by 30 minutes of functional task training. for the participants in the seq group, 20 minutes of tdcs will be applied prior to mt, while tdcs will be applied concurrently with mt for the first 20 minutes in the con group. as for the sham group, tdcs electrodes will be placed on the scalp without actual current output. the interventions will be carried out 90 minutes per day, 5 days per week, for 4 weeks. behavioral outcomes will be assessed by blinded evaluators before, after, and 3 months post intervention. to study the possible interaction of treatment group and time of outcome evaluations, group (seq vs. con vs. sham groups) × time (pretest vs. posttest vs. follow-up) repeated measures anova will be performed. additionally, the partial eta square (η2) will be calculated to determine the effect size of interest.

Eligibility criteria:
inclusion criteria: 1. experienced a first-ever unilateral stroke with stroke onset ≥ 1 week; 2. ue-fma score between 18 and 56 3. able to follow instructions to perform the tasks (mini mental state examination ≥ 24) exclusion criteria: 1. participants are currently involved in other rehabilitation or drug research trial(s); 2. have neurological or psychological disorders other than stroke; 3. have joint contracture or excessive spasticity of the paretic upper limb that prohibits them performing the tasks; 4. received botulinum toxin injections 3 months prior to enrollment 5. have unstable cardiovascular status such as uncontrolled hypertension or new york heart association (nyha) class iii/iv heart failure; 6. have contradictions to tdcs including a history of epilepsy, migraine headache, uncontrolled medical status, being pregnant, having a pacemaker, or metal implanted in their head or body 7. have a history of drug or alcohol abuse, skin lesions on the electrode sites, brain tumor, brain injury, arteriovenous malformation (avm), had brain surgery, other brain diseases (such as intracranial hypertension or cerebral edema), or being not suitable for using tdcs by the physician's assessment.

Keywords: mirror therapy transcranial direct current stimulation stroke neurorehabilitation
controlled education of patients after stroke

Conditions: Stroke; Hypertension

Summary: the main objective of the study is to compare the benefit of optimised follow-up by nursing personnel from the vascular neurology department, including therapeutic follow-up and an educational program directed to the patient and a caregiving member of his social circle, with that of a typical follow-up.


Eligibility criteria:
inclusion criteria: * patients over 60 years of age * patients who have had a first stroke, transient or permanent, ischaemic or haemorrhagic, justifying hospitalisation * patients with high blood pressure already treated or discovered at the time of the stroke and justifying the start of a treatment * patients who have had a stroke with sequelae allowing immediate return home or justifying a stay of less than one month in rehabilitation * patient having a member of his social circle who has agreed to provide follow-up for two years in association with the assigned nursing personnel in case of randomisation into the "optimised follow-up" group. exclusion criteria * patients less than 60 years of age * patients with a history of stroke * patients who do not have high blood pressure discovered by a treatment prior to the stroke or by abnormal blood pressure figures during hospitalisation * patients who have had a stroke causing serious sequelae, justifying an extended stay in a rehabilitation department * patient who has no one in his social circle capable of working with the assigned nursing personnel, or patient living in an institution

Keywords: stroke hypertension secondary prevention educational program