Kornimate/medical-research-clean huggingface dataset:
create trial, prospective, observational study

Conditions: Coronary Artery Disease; Drug Eluting Stent

Summary: observation of the safety and effectiveness of cre8 stent, cre8 evo stent in patients with ischemic heart disease with long coronary lesions

the purpose of this study is to observe the prognosis of 300 patients with long lesions over 30 mm treated with a new-generation cre8 stent, cre8 evo stent that is polymer-free and releases fat-soluble ampilimus in the real world. in addition, in the case of inserting a 46mm very long stent through sub-analysis, we also want to check whether stent expansion is performed through oct rather than ivus.

Eligibility criteria:
inclusion criteria: 1. 19 years of age or older 2. clinical evidence of coronary artery disease, including asymptomatic ischemia, stable angina, and acute coronary syndrome (unstable angina, non-st-segment elevation myocardial infarction, st-segment elevation myocardial infarction) 3. coronary artery lesion length 30 mm or more 4. those who voluntarily agreed in writing to participate in this clinical study exclusion criteria: 1. remaining life expectancy is less than 1 year 2. subjects with known hypersensitivity or contraindication to the following drugs or substances: heparin, aspirin, clopidogrel, prasugrel, ticagrelor 3. in case the other researcher judges that it is inappropriate to participate in this study (pregnant women, the elderly, etc.)
commensality groups: a professional fulfillment intervention for medical students in their clinical years

Conditions: Professional Fulfillment; Burnout; Social Isolation or Loneliness

Summary: medical students are at high risk for burnout, depression, anxiety, suicidal ideation and substance use disorder with burnout seen as a mitigating factor for suicidal ideation. help-seeking among medical students suffering from burnout is only 30%. the highest rates of burnout among medical students is at the end of their clinical rotations, with estimates of up to 60%. "commensality groups" have been found to significantly reduce burnout and improve meaning in work by creating opportunity for connection and collegiality among physicians. these groups consist of providing a reimbursed monthly meal with structured questions that generate conversation for the first 15 minutes with 6-8 participants meeting monthly, for six months. physician participants in commensality groups maintain these gains one year later. the investigators propose to apply the model of commensality groups to medical students who are launching into their experience clinical practice, and have been on clinical rotations for at least 4 months. the investigators will form randomly assigned groups of 6-8 medical students with 1 resident leader. the resident leader role has been added to encourage compliance with the standardized discussion questions and to avoid the potential negative impact of a "venting" session. the overall intention of this study is to explore whether commensality groups can increase well-being for medical students in their clerkship years, as it has previously been shown to do for residents and physicians.


Eligibility criteria:
inclusion criteria: * currently a medical student on clerkships at the keck school of medicine of the university of southern california exclusion criteria: * not currently on a leave of absence, research year, or otherwise not enrolled in the medical school program

Keywords: commensality groups medical students
mechanisms of hypoglycemia associated autonomic dysfunction, q4-atomoxetine

Conditions: Type 1 Diabetes

Summary: this study is aimed at determining if the drug atomoxetine (strattera-used to treat attention deficit hyperactivity disorder(adhd) has effects on the body's ability to defend itself against low blood sugar.

the purpose of this study is to see if the drug atomoxetine (strattera) has effects on the body's ability to defend itself against low blood sugar. normally, when blood sugar levels drop below normal, the body creates a series of responses, which increase the sugar inside the body to bring blood sugar levels back to normal. the hormone epinephrine is a key defense against low blood sugar in people with diabetes. atomoxetine has been shown to increase this hormone level. thus, any approaches to increase levels of this key defense during low blood sugar may have great value.

Eligibility criteria:
inclusion criteria: * healthy individuals aged 18-50 years * type 1 diabetes individuals aged 18-50 years * bmi \<40 kg/m2 * females of childbearing potential with negative urine pregnancy test * volunteers over 40 years of age, a cardiac stress test with no clinically significant conduction or ischemic changes exclusion criteria: the following groups of subjects will be excluded from the study: * pregnant women * subjects unable to give voluntary informed consent * subjects on anticoagulant drugs or with known bleeding diatheses * subjects with uncontrolled hypertension, heart disease, cerebrovascular incidents * subjects taking maois * subjects with narrow angle glaucoma * subjects with diagnosed psychiatric disorders * subjects with allergy to atomoxetine, heparin, or lidocaine physical exam exclusion criteria: * uncontrolled severe hypertension (i.e., blood pressure greater than 150/95) * clinically significant cardiac abnormalities (e.g. heart failure, arrhythmias, ischemic tachycardia, s-t segment deviations, etc.) from history or from cardiac stress testing in subjects \> 40 years old. * pneumonia * hepatic failure/jaundice * renal failure * acute cerebrovascular/ neurological deficit * fever greater than 38.0 c screening laboratory tests exclusion criteria blood values as defined in protocol
educational follow-up in a cohort of children at the royal marsden hospital (rmh)

Conditions: Brain Tumour

Summary: to document pre-diagnosis educational abilities, to document any change in educational achievements following treatment, to document educational support given within the statement process and to document the timing of support.

this will be a retrospective study. cases will be identified by looking at the royal marsden hospital (rmh) coding database. all the patients will have completed treatment for a brain tumour. the children all need to have started school before the diagnosis of their brain tumour so that we can look at easily defined educational assessments in this cohort. children will be identified by looking at rmh coding of diagnosis and include children aged between 4 years and 18 years old (school age).

Eligibility criteria:
inclusion criteria: * patients/parental consent for rmh accessing educational information from them and their school * patients with a primary brain tumour exclusion criteria: * children with secondary brain tumours * children who have had treatment for a relapse of primary brain tumour

Keywords: brain tumour
recovery: a transdiagnostic intervention for anxiety and depression

Conditions: Depression; Dysthymic Disorder; Panic Disorder; Social Phobia; Generalized Anxiety Disorder; Specific Phobia

Summary: to investigate the efficacy and acceptability of a guided internet delivered transdiagnostic intervention, targeting mild to moderate clinical symptoms of anxiety and depression and emphasizing the changes taking place at the level of the structures of the self.

the effectiveness of a transdiagnostic cognitive-behavioral treatment will be compared with an improved version of it, in which new intervention techniques were added, pointing out the importance of improving some self-concept dimensions in reducing symptoms of anxiety and depression. in order to prove this, the study design will include two active intervention groups; a standard transdiagnostic intervention protocol will be delivered to one group and an improved version of the same transdiagnostic protocol will be delivered to the other group. the new added techniques targets some self-concepts, namely self-compassion, unconditional self-acceptance and self-esteem. the main goal of the study is to concurrently test effectiveness of these two transdiagnostic approaches in reducing symptoms of anxiety and depression and improving the above-mentioned self-concepts. this non-inferiority trial has the power to detect an effect size larger than cohen's d = .40 (including 20% attrition at post-test and 6 month follow-up)

Eligibility criteria:
inclusion criteria: 1. be fluent in romanian, 2. be at least 18 years of age, 3. have at least a clinical diagnosis of major depressive disorder/dysthymia, and/or generalized anxiety disorder, and/or social anxiety disorder, panic anxiety disorder and/or agoraphobia, specific phobia or any combination of these conditions on structured clinical interview for the diagnostic and statistical manual for mental disorders 5 (scid-i 5) exclusion criteria: 1. suicidal plans, 2. changes in the dosage if psychotropic medication during the last month (if present), 3. have bipolar disorder or psychosis (according to medication status), 4. have an alcohol/substance abuse and/or dependence disorder, 5. currently take part in other psychological treatment, 6. obvious obstacle to participation (i.e., no current internet access, long travel plans during the treatment period etc.)

Keywords: transdiagnostic cognitive behavioural therapy (cbt) depression anxiety
effect of low level laser versus interferential current on postmenopausal low back pain

Conditions: Low Back Pain

Summary: this study will be conducted to compare the effect of low-level laser and interferential current on postmenopausal low back pain.

low back pain (lbp) is a major health problem affecting majority of the people at some point of their life.the prevalence of postmenopausal lbp is 32.4%. it has major implication for quality of life, such as limitation of daily activities and physiological stress, being one of the main causes of work absenteeism. the prolonged use of nsaids is associated with cardiovascular, hepatic, and renal problems. therefore, there is a need for emphasis on alternative methods of conservative treatment as non-pharmacological and non-invasive therapy to relieve postmenopausal lbp. low level laser has been proven to have an impact on postmenopausal lbp, through several mechanisms as (a) increased endogenous opioid neurotransmitter production ;(b)raised threshold to thermal pain and enhanced local blood circulation ; (c)increased oxygen consumption by accelerating the redox reaction rate of the electron respiratory chain of mitochondria ; (d) increased adenosine triphosphate (atp) production at the cellular level ;(e) increased production of the anti-inflammatory cytokines. also, another non- invasive technique is the interferential current which is one of the existing electrotherapy treatments used to reduce pain and has been studied for its effectiveness in relieving lbp through its deeper penetration into the tissues. so, this study will be conducted to provide new evidence and information about the efficacy of low-level laser versus interferential current on lbp in postmenopausal women

Eligibility criteria:
inclusion criteria: • sixty postmenopausal women (at least one year after stoppage menses). * their age will be ranged from 50 to 60 years. * their body mass index (bmi) will be less than 30 kg/m2. * all of them suffer from chronic low back pain (at least 3 months). * the score of pain will be 2 or more according to visual analogue scale (vas). exclusion criteria: * spinal fracture or any other neurological disorder. * lumbar disc herniation, degenerative joint diseases, or spondylolisthesis. * bmi\>30 kg/m2 * gynecological diseases as chronic pelvic pain or genital prolapse.
safety of 250ml preoperative carbohydrate drink in gastric cancer patients

Conditions: Gastric Cancer

Summary: this study aims to assess the impact of preoperative oral carbohydrate drink on gastric emptying and ph of gastric fluid in gastric cancer patients directly. furthermore, investigators aim to evaluate the safety and effectiveness of preoperative oral carbohydrate in elective gastric cancer surgery, providing direct evidence for clinical practice.

in clinic, administration of oral carbohydrate 2-3 hours before surgery has been widely applied in elective colorectal surgery. however, no direct evidence has been showed that whether it is safe to do so in gastric cancer patients who are fit for elective radical gastric resection. this study aims to discuss the impact and safety of oral administration of 5% glucose solution 250ml 2-3 hours before elective gastric cancer surgery. it is an equivalence study, which refers to a single-center, prospective, single blind, and randomized controlled study design. eighty-eight patients with gastric adenocarcinoma are going to be enrolled in the study, who will be allocated into control or treatment group. patients in control group follow the traditional routine of 6-8 hours preoperative fasting, while those in the treatment group will orally intake 250ml 5% glucose solution 2-3 hours before surgery. the primary end-point is the preoperative gastric residual volume. the secondary end-points include preoperative ph of gastric fluid, assessment of perioperative psychosomatic conditions, rate of perioperative complications, level of insulin sensitivity, recovery of bowel function, and the length of hospital stay, etc.

Eligibility criteria:
inclusion criteria: * age between 18 and 80 years * histologically confirmed gastric adenocarcinoma * tumor of ct2-4an0-2 in preoperative gastroscopy, endoscopic ultrasound, and/or abdominal computed tomography * fit for elective radical resection * eastern cooperative oncology group (ecog) performance status of 0 or 1 * american society of anesthesiology (asa) status i to iii * body mass index (bmi) of 17.5-27.5 kg/m2 .patient agreed to participate this trial through informed consent. exclusion criteria: * symptoms of pyloric obstruction * impaired bowel function, using drugs disturbing gastric secretion and gastric emptying * history of gastric resection * history of gastric cancer treatment * history of major abdominal operation, or diffuse peritonitis * diabetes or impaired glucose tolerance, or with abnormality in other endocrine hormones * potential difficult airway as evaluated by anesthesiologist * pregnancy or breastfeeding were excluded in this trial .patients would also be excluded if the following circumstances occurred: (1) failure of endotracheal intubation; (2) failure of intra-operative gastroscopy; or (3) irresectable tumor.
european venous registry

Conditions: Deep Venous Disease of the Lower Limbs

Summary: the european venous registry (ever) is an international repository of data on the treatments and outcomes of people with deep venous disease. the registry is designed to evaluate the outcomes of venous interventions over a ten-year period, with the ultimate goal to inform clinical decision making through the delivery of scientific evidence.


Eligibility criteria:
inclusion criteria: * patients with an imaging-confirmed new diagnosis of acute or chronic lower limb deep venous disease involving the iliac and/or common femoral veins, with or without extension to the inferior vena cava, or patients with an imaging-confirmed new diagnosis involving the ivc only. * consent to enter registry. exclusion criteria: * unable to consent to enter into registry. * isolated upper limb dvt. * central venous thrombosis (e.g. superior vena cava obstruction). * isolated deep vein thrombosis below the common femoral vein. * isolated superficial venous thrombosis. * isolated superficial venous thrombophlebitis. * isolated varicose veins. * aged \<18 years.

Keywords: acute or chronic lower limb deep venous disease iliac and/or common femoral veins inferior vena cava
effect of fast hugs with icu approach on length of intensive care unit stay in patients with hypoxic respiratory failure

Conditions: Hypoxic Respiratory Failure

Summary: this study will investigate the effect of the fast hugs with icu approach on the length of stay in the intensive care unit in patients with hypoxic respiratory failure. patients will be randomly assigned to the experimental and control groups. the standard procedure will be applied to the control group. the fast hugs with icu approach will be applied to the experimental group. we plan to follow up patients with hypoxic respiratory failure using the abbreviation fast hugs with icu (feeding, analgesia, sedation, thromboembolic prophylaxis, head of bed elevation, stress ulcer prophylaxis and glucose control spontaneous breathing trial, water balance and constipation, investigation and results, therapy, hypo-hyper delirium, invasive devices, check the daily infection parameters, use a checlist). the two groups will be examined in terms of hospital stay and some blood gas parameters.

hypoxic respiratory failure is responsible for 1.9 million patient admissions per year in the united states alone, and the hospital mortality rate is as high as 20%. this rate is also increasing in turkey. the most common causes include pneumonia, cardiogenic pulmonary edema, ards, and chronic obstructive pulmonary disease (copd). fast hugs is important in affecting the prognosis of patients with hypoxic respiratory failure in special clinics such as the chest diseases intensive care unit. therefore, new studies are needed. this study will investigate the effect of the fast hugs with icu approach on the length of stay in the intensive care unit in patients with hypoxic respiratory failure. patients will be randomly assigned to the experimental and control groups. the standard procedure will be applied to the control group. the fast hugs with icu approach will be applied to the experimental group. we plan to follow up patients with hypoxic respiratory failure using the abbreviation fast hugs with icu (feeding, analgesia, sedation, thromboembolic prophylaxis, head of bed elevation, stress ulcer prophylaxis and glucose control spontaneous breathing trial, water balance and constipation, investigation and results, therapy, hypo-hyper delirium, invasive devices, check the daily infection parameters, use a checlist). the two groups will be examined in terms of hospital stay and some blood gas parameters.

Eligibility criteria:
inclusion criteria: * being over 18 years old * being in the chest intensive care unit * having hypoxic respiratory failure exclusion criteria: * death during hospitalization

Keywords: hypoxic respiratory failure
effect on early somatic growth of a daily kinesthetic stimulation on preterm infants

Conditions: Preterm Infant; Growth Acceleration; Neurobehavioral Manifestations

Summary: kangaroo position (kp), the essential component of the kangaroo mother care (kmc) method, has been increasingly implemented, given the benefits of early skin-to-skin contact on the cerebral maturation of preterm infants. in addition it allows for parents to bond with their infants and humanize the care of fragile infants in neonatal units. evidence on kinesthetic stimulation (ks) is scarce and currently there is no available evidence on ks during the kp. ks is associated with massage in this paper

the objective is to study the impact of standardized ks delivered either in kp (kskp) or in an incubator (ksi) on the early growth of very preterm infants. patients and methods: sixty six newborns ≤32 weeks of gestational age at birth received ks delivered 3 times/day during kp or in an incubator. they were randomized when the infants were considered eligibleto initiate kmc which was part of the routine care for all newborns in the neonatal care unit (ncu). the primary outcome were the weight gain (g/kg/day) between randomization, 5, and 15 days after the start of the intervention and weight at 40 weeks of gestational age (term). the secondary outcomes were the same measures according to the chronological age (days of life) of the infant at randomization.

Eligibility criteria:
inclusion criteria: * preterm infants (ga ≤33 weeks of gestation) * deemed clinically stable and eligible for the kmc intervention by the neonatologist were included. exclusion criteria: * infants with congenital anomalies * unstable during the first 15 days of life

Keywords: kangaroo position kinesthetic stimulation kangaroo mother care bonding
short-term outcome after ventral hernia repair

Conditions: Short-term Outcome After Ventral Hernia Repair

Summary: hernia repair in sublay technique is widely accepted for ventral hernias, as it appears to be advantageous in terms of complication and recurrence rates. recently, self-gripping meshes are increasingly used for hernia repair with retromuscular mesh positioning. however, real-life data on the safe use in that specific indication are still lacking. therefore, this study evaluated short-term postoperative outcome of self-gripping versus conventional non-self-gripping meshes in sublay hernia repair.


Eligibility criteria:
inclusion criteria: * ventral hernia repair in sublay technique exclusion criteria: * ventral hernia repair in other technique
a phase i study of recombinant human cd4 immunoglobulin g (rcd4-lgg) in patients with hiv-associated immune thrombocytopenic purpura

Conditions: Immune Thrombocytopenic Purpura ( ITP ); HIV Infections

Summary: to test the effectiveness of recombinant human cd4 immunoglobulin g (cd4-igg) in the treatment of hiv-associated immune thrombocytopenic purpura in patients with all levels of hiv infection.


Eligibility criteria:
inclusion criteria concurrent medication: allowed: * dapsone at a constant dose level and only as a prophylaxis for pneumocystis carinii pneumonia (pcp). * zidovudine (azt) at a constant dose for the 12 weeks of treatment, except if azt-related toxicity is observed. patients must have the following: * hiv seropositive (asymptomatic, aids-related complex, or aids). * hiv-associated immune thrombocytopenic purpura. * the ability to sign a written informed consent form, which must be obtained prior to treatment. * a willingness to abstain from all other experimental therapy for hiv infection during the entire study period. * patients currently on zidovudine are not excluded. however, the zidovudine dose level must remain constant for 4 weeks prior to entry and for the 12 weeks of treatment, except if zidovudine related toxicity is observed. * a life expectancy of at least 3 months. prior medication: allowed: * dapsone at a constant dose for more than 2 weeks prior to study entry. * zidovudine at a constant dose for 4 weeks prior to study entry. exclusion criteria co-existing condition: patients with the following conditions and symptoms are excluded: * active serious opportunistic infection (excluding positive block cultures of mycobacterium avium complex or cytomegalovirus). * malignancies other than kaposi's sarcoma. * tumor-associated edema. * visceral kaposi's sarcoma. * significant neurologic, cardiac, or liver disease. concurrent medication: excluded: * ganciclovir (dhpg). pyrimethamine. clindamycin. sulfadiazine. folinic acid. prednisone. intravenous gamma globulin. intravenous acyclovir. interferon. systemic corticosteroids. non-steroidal anti-inflammatory drugs (nsaids). known immunomodulatory agents. dideoxycytosine. dideoxyinosine. nucleoside analogs (with the exception of zidovudine or topical acyclovir). any experimental therapy. patients with the following are excluded: * active serious opportunistic infection (excluding positive block cultures of mycobacterium avium complex or cytomegalovirus). * malignancies other than kaposi's sarcoma. * kaposi's sarcoma requiring therapy. * tumor-associated edema. * visceral kaposi's sarcoma. * significant neurologic, cardiac, or liver disease. * conditions requiring excluded concomitant medications. * herpes virus infection requiring intravenous acyclovir. prior medication: excluded for a minimum of 4 weeks prior to study entry: * chemotherapy. * immunomodulatory agents. * any experimental therapy. prior treatment: excluded for a minimum of 4 weeks prior to study entry: * radiation therapy. * any experimental therapy.

Keywords: recombinant proteins igg drug evaluation antigens, cd4