Kornimate/medical-research-clean huggingface dataset:
surgical therapy and survival in hcc/ c.f. zhang et al.

Conditions: Hepatocellular Carcinoma; Surgery

Summary: this study utilizes a new method to explore compare the overall survival (os) and cancer-specific survival (css) in patients aged 18-45 years with stage i-ii hcc who underwent different types of surgery. the seer database, which is one of the most comprehensive and authoritative databases concerning cancer, was used to estimate the survival benefit of patients who underwent local tumor destruction (ltd), wedge or segmental resection (wsr), lobectomy resection (lr), liver transplantation (lt), or non-surgery. this study discovered surgery offered a survival benefit compared with non-surgery for young patients with stage i-ii hcc. furtherly, lt is associated with superior survival than wsr, lr and ltd in those patients. our results facilitate the selection of surgical strategies.

the seer data contain no identifiers and are publicly available for studies of cancer-based epidemiology and survival analysis. therefore, the current study was deemed to be exempt from institutional review board approval and the need for informed consent was waived. the submitted magazine requires registration on the website, so this operation is needed.

Eligibility criteria:
inclusion criteria: 1. patients were diagnosed with colorectal cancer only; 2. patients with simultaneous metastasis of liver and lung cancer cells; 3. patients without metastasis resection; 4. whether they underwent palliative primary tumor resection was known; 5. their cause of death was known; 6. their survival time were known and greater than 0 month; 7. patients were diagnosed with microscopic confirmation. exclusion criteria: * no
adjusted study protocol: within-subject paired-eye design comparing pilocarpine 0.1%, phentolamine 0.75%, and combination therapy for cyclopentolate reversal in children

Conditions: Pupillary Constriction; Accomodation

Summary: the study aims at reversing pupillary dilatation. and cycloplegia in children undergoing cycloplegic refraction for eyeglasses prescription and ocular examination. this will be achieved using pilocarpine , phentolamine or a combination. this may help decrease the glare and improve near vision early to decrease unwanted effects of cycloplegic drops.

to compare the efficacy of pilocarpine 0.1%, phentolamine 0.75%, and combined therapy in reversing cyclopentolate-induced cycloplegia/mydriasis in pediatric patients using a within-subject paired-eye design (treated vs. untreated eye). interventions cycloplegia induction: both eyes receive cyclopentolate 1% (2 drops, 5 minutes apart). then cycloplegic effect confirmed at 30 minutes (accommodation ≤2 d, pupil ≥6 mm). reversal agents (administered at 30 minutes post-cyclopentolate): pilocarpine group: pilocarpine 0.1% (1 drop) in the study eye; placebo in the control eye. phentolamine group: phentolamine 0.75% (1 drop) in the study eye; placebo in the control eye. combination: pilocarpine 0.1% + phentolamine 0.75% (1 drop each) in the study eye; placebo in the control eye.

Eligibility criteria:
inclusion criteria: * children between 5 and 12 years undergoing cycloplegia exclusion criteria: * patient refusal
investigation of marginal bone loss in implants with different surface properties and geometric designs: a retrospective clinical study

Conditions: Implant Infection; Peri-Implantitis; Bone Loss

Summary: purpose: the aim of this study was to investigate the influence of surface characteristics and geometric design on marginal bone loss and bone quality in dental implants. materials and methods: a total of 378 implants from 114 patients were evaluated in this study using panoramic and periapical radiographs. implants were categorized into 19 subgroups according to the jaw where they were placed, length, diameter, surface preparation, type of prosthetic superstructure, and neck design. radiological evaluations were conducted based on radiographs obtained at the time of implant placement and 3 months after prosthetic loading. after obtaining measurements of marginal bone loss and fractal analysis data, the significance of differences between groups was statistically evaluated.


Eligibility criteria:
inclusion criteria: * implants with a minimum length of 8 mm * implants with a minimum diameter of 3.5 mm * availability of panoramic and periapical radiographs at t0 (immediately after surgery) and t1 (3 months after prosthetic loading). exclusion criteria: * presence of a systemic condition hindering dental implant treatment and routine check-ups * history of regular alcohol/tobacco use * presence of severe parafunctional habits (bruxism, etc.) * prior grafting procedures before dental implant placement * implant failure

Keywords: dental implant marginal bone loss peri-implantitis fractal analysis
high flow oxygen therapy in patients undergoing bronchoscopy under sedation

Conditions: Respiratory Failure; Hypercapnic Acidosis

Summary: a reduction of peripheral oxygen saturation (spo2) commonly occurs during bronchoscopy and may be associated with both respiratory and cardiac adverse events. the type of breathing assistance that should be delivered to patients, in order to treat and/or to prevent acute respiratory failure, during or after bronchoscopy, is not universally standardized; studies comparing the impact of different respiratory supports on patient's outcome and on hospital resource use are very few. the risk of respiratory failure rises according to the type of procedure (i.e., increased risk with broncho-alveolar lavage and trans-bronchial lung biopsy) and to the use of sedative drugs. conventional oxygen therapy with nasal cannula, continuous positive airway pressure and non-invasive ventilation are commonly applied during endoscopic procedures. high flow oxygen therapy (hfot) is a relatively novel device, still under-used in the context of interventional pulmonology, providing an humidified air-oxygen blend up to 60 l/min. hfot has been reported to be effective for the treatment of both hypoxemic and hypercapnic respiratory failure. the investigators hypothesize that hfot could be feasible and safe in patients undergoing bronchoscopy under moderate sedation, affected by or at risk of hypoxemic and/or hypercapnic respiratory failure.


Eligibility criteria:
inclusion criteria: * ph ≥7.30 e paco2 \>45 mmhg and/or * pao2/fio2 \<300 mmhg o spo2 \<90 percent on room air * patient at risk of respiratory failure (copd iii-iv gold stage; osas; restrictive lung and chest wall diseases; cardiac failure) exclusion criteria: * need of laryngeal mask and/or * patients on niv for \>16 hrs/day and/or * ph \<7.30 and/or * tracheostomy and/or * recent (\<3 months) facial trauma and/or * hemodynamic instability and/or * high risk of aspiration and/or * lacerated trachea

Keywords: bronchoscopy sedation high flow oxygen therapy
acupuncture for the management of postoperative pain in patients with pancreatic or colorectal cancer undergoing surgery

Conditions: Resectable Colorectal Carcinoma; Resectable Digestive System Carcinoma; Resectable Pancreatic Carcinoma

Summary: this trial investigates how well acupuncture works for the management of pain after surgery in patients having open colorectal or pancreatic surgery. acupuncture may help to reduce postoperative symptoms including pain. this study may help researchers learn if acupuncture reduces after-surgery side effects and improves recovery.

primary objective: i. determine the feasibility of providing postoperative acupuncture for patients undergoing open colorectal or pancreatic surgery. secondary objective: i. compare postoperative opioid use for pain management, pain levels, and satisfaction of pain control between acupuncture and standard care groups. exploratory objective: i. compare dietary recovery and postoperative length of stay between acupuncture and standard care groups. outline: patients are randomized to 1 of 2 arms. arm i (acupuncture): beginning the day after surgery, patients undergo acupuncture sessions over 25 minutes once daily (qd) for up to 7 days. patients also undergo usual care including preoperative visits to the primary surgical team, anesthesia preoperative evaluation, referrals to other specialties for perioperative evaluation and optimization of comorbid conditions if necessary, surgical operations, postoperative hospitalization, and post-discharge clinic visits. arm ii (usual care): patients undergo usual care including preoperative visits to the primary surgical team, anesthesia preoperative evaluation, referrals to other specialties for perioperative evaluation and optimization of comorbid conditions if necessary, surgical operations, postoperative hospitalization, and post-discharge clinic visits.

Eligibility criteria:
inclusion criteria: * undergoing open gastrointestinal cancer resection (pancreatic or colorectal) * must understand and read english * sign a written informed consent and willing to follow protocol requirements * able to consent to treatment exclusion criteria: * chronic opioid use \> 90 mg mme (morphine milligram equivalents) for more than 7 days * mechanical bowel obstruction * active seizure activity after admission * compromised cognitive function per referring physician and/or inability to cooperate with acupuncture procedure * direct admission to intensive care unit after operation will result in removal from protocol * prior intra-abdominal operation in the past 6 months * any contraindications to acupuncture including infections or inability to access acupoint sites
secondary prevention with paroxetine vs. placebo in subthreshold posttraumatic stress disorder (ptsd)

Conditions: Stress Disorders, Post-Traumatic

Summary: the purpose of this study is: 1) to document the effectiveness and tolerability of paroxetine for the treatment of subthreshold posttraumatic stress disorder (ptsd) in veterans in the early post-deployment period; and 2) to determine the potential efficacy of paroxetine in preventing the progression of anxiety symptoms to ptsd and other anxiety disorders, and improving overall veteran function.

see brief summary

Eligibility criteria:
inclusion criteria: 1. veterans 18-55 years of age 2. diagnosis of subthreshold ptsd (at least one symptom in ptsd symptom clusters b, c, and d by structured interview; with or without functional impairment exposure to war zone stressors) 3. written informed consent; and 4. a negative serum pregnancy test for women of childbearing potential. exclusion criteria: 1. lifetime history of dsm-iv diagnosis of bipolar disorder, schizophrenia or other psychotic disorder, or cognitive disorder due to a general medical condition 2. history of substance dependence within the last 3 months 3. significant suicide risk or serious suicide attempt within the last year 4. clinically significant medical condition or laboratory or ekg abnormality 5. women of childbearing potential who are unwilling to practice an acceptable method of contraception 6. subjects needing concurrent use of psychiatric medications 7. history of hypersensitivity to paroxetine 8. hads depression subscale score \> 12 9. failure to respond to an adequate trial of paroxetine (20 mg/day x 8 wks).

Keywords: ptsd paroxetine subthreshold
disparities in national kidney allocation policy

Conditions: Kidney Disorders

Summary: the purpose of the current study is to test a systems-level approach to disseminate a multicomponent, multilevel intervention consisting of educational materials about transplantation and the new kidney allocation system targeting dialysis facility medical directors, staff, and patients. roughly 750 dialysis facilities in up to 18 end stage renal disease network regions across the united states will be randomized to receive intervention materials. the overall goal of the study is to extend the influence of the national allocation policy in reducing disparities in early steps in kidney transplant access.

the purpose of the ascent study is to test a systems-level approach to disseminate a multi-component intervention consisting of in the era of the new national kidney allocation policy and educational materials targeting dialysis facility medical directors, staff, and patients. the investigators will randomize \~750 dialysis facilities in up to 18 end stage renal disease network regions across the united states, where approximately half of facilities will receive the intervention materials and half will receive an informational brochure. this pragmatic, clinical effectiveness-implementation study will test the effectiveness of the multicomponent, multilevel interventions consisting of a tailored, facility-specific transplant and disparity performance report, educational videos for staff and dialysis patients, and an educational webinar for dialysis facility medical directors and staff.

Eligibility criteria:
inclusion criteria: dialysis facilities with at least 25 patients composed of at least 10% african american and 10% caucasian exclusion criteria: dialysis facilities with wait listing rates above the national tertile

Keywords: transplantation surgery nephrology organ and tissue transplantation
percutaneous needle electrolysis (pne) in soleus injury

Conditions: Soleus Injury

Summary: this study evaluates if the physiotherapy treatment based on eccentric exercise, ultrasound-guided pne or a combination of both therapies on chronic soleous injuries may cause changes in pain, functionality, dorsal flexion of the foot, balance and muscle fatigue in dancers.


Eligibility criteria:
inclusion criteria: * over 16 years. * at least 5 years of formal dance training. * at least 20 hours of training per week. * pain in the back of the leg * diagnosis of chronic soleus injury exclusion criteria: * unsurpassed fear of needles * history of adverse reactions to needles * immune system disorder * difficulty expressing your feelings properly * epilepsy and / or allergies to metals. * other lower limbs pathology
evaluation of postoperative ascites after somatostatin infusion following hepatectomy for hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma

Summary: most patients undergoing hepatectomy for hepatocellular carcinoma (hcc) suffer from underlying liver disease and are exposed to the risk of postoperative ascites, with subsequent morbidity, liver and renal failure, the need for specific treatments and prolonged hospital stay. postoperative ascites is favored by an imbalance between portal venous inflow and the diminished hepatic venous outflow. finding a reversible, non-invasive method for modulating the portal inflow would be of interest: it could be used temporarily during the early postoperative course to prevent acute portal hypertension. somatostatin, a well-known drug already used in several indications, may limit the risk of postoperative ascites and liver failure by decreasing portal pressure after hepatectomy for hcc in patients with underlying liver disease.


Eligibility criteria:
inclusion criteria: * patients with hcc diagnosed by histology or by imaging findings according to the barcelona clinic liver cancer group * patients with a single or multiple hccs deemed to be resectable with a curative intent at the preoperative evaluation * patients for whom an indication for hepatectomy has been decided and approved by multidisciplinary board: * by laparotomy * by coelioscopy with resection of at least 2 liver segments * patients with any underlying liver disease with or without proven cirrhosis, regarding histological features (including f2-f3-f4 fibrosis with or without cirrhosis) or with other evidence of a diseased liver if no biopsy has been performed preoperatively (dysmorphic liver or evidence of portal hypertension at imaging findings, oesophageal varices at endoscopy) * age ≥ 18 years * patients with ability to understand and sign a written inform consent form * patients who will be available for follow-up exclusion criteria: * patients participating in another interventional research in progress or including an exclusion period still in progress at pre-inclusion (except interventional research with minimal risks and constraints that do not interfere with the judgement criteria of the study according to the judgement of the coordinating investigator). * patients with evidence of a healthy liver at biopsy disease-associated non-inclusion criteria include: * another histologic type of hepatic tumor besides hcc * distant extra-hepatic metastases, including peritoneal carcinomatosis * the existence of complete portal thrombosis of the main portal trunk operative technique-associated non-inclusion criteria include: - indication of coelioscopy with resection of less than 2 liver segments

Keywords: hepatocellular carcinoma hepatectomy ascites somatostatin
a study of tarceva (erlotinib) following platinum-based chemotherapy in patients with advanced, recurrent, or metastatic non-small cell lung cancer (nsclc)

Conditions: Non-Small Cell Lung Cancer

Summary: this 2 arm study will evaluate the efficacy, safety, and pharmacokinetics of tarceva, compared with placebo, following platinum-based chemotherapy in patients with advanced, recurrent, or metastatic nsclc who have not had disease progression or unacceptable toxicity during chemotherapy. following 4 cycles of platinum-based chemotherapy, eligible patients will be randomized to receive either tarceva 150mg po daily, or placebo daily. the anticipated time on study treatment is until disease progression; the target sample size is 500+ individuals.


Eligibility criteria:
inclusion criteria: * adult patients \>=18 years of age; * histologically documented, locally advanced , recurrent or metastatic nsclc; * measurable disease; * no disease progression after 4 cycles of platinum-based chemotherapy. exclusion criteria: * unstable systemic disease; * any other malignancies in the last 5 years.
1 year mri followup in facioscapulohumeral muscular dystrophy

Conditions: FSHD - Facioscapulohumeral Muscular Dystrophy

Summary: an investigation of disease progression in adult danish patients with facioscapulohumeral muscular dystrophy. the disease progression is followed for a year with two test-days, including functional muscle tests and a mri scan of muscles in the back and legs.

a cohort of adult danish patients with facioscapulohumeral muscular dystrophy is invited to perform a mri scan to describe the relation between backpain and disease affection in back muscles. after one year they are re-invited to perform another mri scan to follow the disease progression. the mri scan is done to measure the quantity and quality of the muscles in the back, thigh and calf. further, investigators investigate the muscle function by measuring of muscle strength in legs and in the back together with three functional tests. a walking test (6mwt), a stair test (14sst), and a chair test (5-tstst). self-assessment of back pain is measured by a standardized questionnaire about backpain.

Eligibility criteria:
inclusion criteria: * diagnosed with fshd type 1 exclusion criteria: * pregnant or breastfeeding women. * patients with claustrophobia. * patients with implanted metallic parts in the body.

Keywords: fshd mri disease progression
effect of cognitive behavioral play intervention and epilepsy

Conditions: Epilepsy; Epilepsy in Children

Summary: the goal of this clinical trial is to assess the effectiveness of cognitive behavioral play therapy interventions in patients with epilepsy. children with epilepsy will be randomly assigned to one of two intervention conditions: the experimental group will receive cognitive-behavioral play intervention, while the control group will engage in free play. assessments will be done at the start (t0) and end (t1) of the intervention, measuring behaviors, coping strategies, positive thinking, problem-solving, and quality of life.

cognitive-behavioral play therapy (cbpt) adapts cognitive-behavioral therapy techniques into a play-based intervention for preschool and school-age children, especially for those facing challenges like hospitalization or chronic illnesses. studies show that play has therapeutic value, helping children understand critical events, reduce anxiety, and cope with illness. this research aims to explore how cbpt can be applied in hospitals, specifically for children with epilepsy, to improve their quality of life, enhance problem-solving, and foster positive coping strategies. the goal is to validate cbpt as a supportive tool for enhancing psycho-emotional development and complementing medical care in hospital settings. the study proposes a randomized controlled trial with two groups: children with epilepsy will be randomly assigned to either the cognitive-behavioral play intervention or free play. the study will assess internalizing and externalizing behaviors, coping strategies, positive thinking, problem-solving skills, and quality of life at baseline (t0) and after the 8 intervention sessions (t1). the goal is to determine whether cognitive-behavioral play improves quality of life more than free play. both groups will participate in 8 weekly 40-minute play sessions, with an initial and final meeting to administer the questionnaires. the psychologist conducting the assessments will be unaware of group assignments. the play scenarios for both groups will be identical and based on common issues faced by children with epilepsy.

Eligibility criteria:
for the purposes of the study, children aged between 6 and 10 years, of both sexes, will be recruited. - inclusion criteria children diagnosed with the following types of epilepsy will be included: childhood self-limiting focal epilepsy (selfe); childhood absence epilepsy (cae); self-limiting centrotemporal paroxysmal epilepsy (selects); self-limiting epilepsy with autonomic seizures (seleas); childhood occipital epilepsy (cove); photosensitive occipital lobe epilepsy (pole). exclusion criteria: * children with epilepsy in comorbidity with cognitive disabilities (the relevant cognitive disabilities must be specified with iq scores) * reduced visual or expressive hearing acuity (visually impaired or deaf) will be excluded.

Keywords: epilepsy psychology cognitive behavioral play therapy