Kornimate/medical-research-clean huggingface dataset:
neurofeedback enhanced cognitive reappraisal training - phase 4

Conditions: Anxiety; Social Anxiety Disorder; Panic Disorder; Generalized Anxiety Disorder

Summary: this study seeks to understand emotion regulation in those with young adults with anxiety using real-time functional magnetic resonance imaging neurofeedback, a tool that allows individuals to control brain activity. the goal of this project is to understand how receiving feedback about one's own brain activity relates to emotion regulation ability. this work will help the study team understand the brain areas involved in emotion regulation and could lay the groundwork to test if psychotherapy outcomes can be enhanced using neurofeedback. the study hypotheses include: * participants receiving veritable-neurofeedback (nf) will show a greater activation increases in the prefrontal cortex (pfc) compared to sham-nf * participants receiving veritable-nf will show greater cognitive reappraisal (cr) ability compared to those receiving sham-nf * pfc activation will positively correlate with cr ability


Eligibility criteria:
inclusion criteria: * primary diagnosis (primary source of distress and/or interference) of generalized anxiety disorder, social anxiety disorder, panic disorder or illness anxiety disorder based on structured interview. comorbid phobic disorders allowed, but these cannot be the primary source of interference or distress due to the lowered chances of encountering anxiety-provoking stimuli during the study period * score of 2 or more on at least 1 question from gad/cross-ad composite * medically and physically able to consent * not regularly taking any medication, prescription or non-prescription, with psychotropic effects other than: 1. buspirone, or antidepressant (e.g., selective serotonin reuptake inhibitor (ssri) or serotonin-norepinephrine reuptake inhibitor (snri)) with stable dosage for past 4 weeks 2. the same oral hormonal contraceptive for at least 3 months * for females, not currently pregnant or actively trying to become pregnant * ability to tolerate small, enclosed spaces without anxiety * no metals, implants or metallic substances within or on the body that might cause adverse effects to the subject in a strong magnetic field, or interfere with image acquisition (per protocol) * size compatible with scanner gantry (per protocol) exclusion criteria: * current diagnosis of obsessive compulsive disorder, posttraumatic stress disorder, or bipolar disorder * current substance abuse or dependence (past 6 months) * active suicidality with plan or intent * current psychosis * history of serious neurological illness or current medical condition that could compromise brain function, such as liver failure * history of closed head injury, e.g., loss of consciousness greater (\>) approximately (\~) 5 minutes, hospitalization, neurological sequela

Keywords: functional magnetic resonance imaging
the role of psychoeducation in breast cancer care

Conditions: Psychoeducation for Patients Who Have Undergone Mastectomy; Mastectomy

Summary: this study aims to examine the effect of psychoeducation on body image and sexual quality of life in female patients who underwent mastectomy due to breast cancer.

method: this randomized controlled trial with two parallel groups was conducted between october 2023 and january 2025 in the general surgery clinic of a university hospital. the sample consisted of 63 patients (31 in the psychoeducation group and 32 in the control group). data collection was conducted using the patient information form, the breast cancer body image scale (bcbis), and the sexual quality of life-female (sqol-f) questionnaire. following the pretest administered to all participants, patients in the psychoeducation group received a 6-week psychoeducation program (90 minutes per week). after the completion of the 6-week intervention, a 4-week waiting period was implemented, after which the posttest was administered to all participants. data analysis included descriptive statistics, chi-square test, t-test, kolmogorov-smirnov test, cronbach's alpha coefficient, anova, and bonferroni post hoc tests.

Eligibility criteria:
inclusion criteria: * women aged between 18 and 60 years * married and/or with a partner, * residing in the city where this study was carried out, * i̇nformed about their diagnosis, * with no physical deformities or functional impairments caused by comorbid conditions or treatments (e.g., lymphedema, hemiparesis, amputation, tracheostomy), * capable of communication, no cognitive impairments or diagnosed psychiatric disorders, * having completed chemotherapy and/or radiotherapy, * with no prior counseling or education related to body image or sexual quality of life. exclusion criteria: * women who were not between the ages of 18 and 60, * not married and/or without a partner, * not residing in the city where the study was conducted, * not informed about their diagnosis, * with physical deformities or functional impairments caused by comorbid conditions or treatments (e.g., lymphedema, hemiparesis, amputation, tracheostomy), * unable to communicate, with cognitive impairments or diagnosed psychiatric disorders, * still undergoing chemotherapy and/or radiotherapy, * had previously received any counseling or education related to body image or sexual quality of life.

Keywords: breast cancer mastectomy psychoeducation body image sexual quality of life
preoperative serum fgf19 in the prognosis of biliary atresia

Conditions: Biliary Atresia; Prognosis

Summary: to investigate the role of preoperative serum fgf19 level in the prognosis of biliary atresia.

kasai portoenterostomy is currently one of the main treatment methods for biliary atresia, but about 30% of children still require liver transplantation even after receiving the surgery. accurate prognosis will help select the most suitable treatment method for children, but there is currently a lack of effective preoperative predictive indicators. serum fgf19 has recently been considered a possible preoperative predictive indicator for biliary atresia, but its predictive value has not been confirmed in a large sample and in asian population, thus the investigators try to further explore the prognostic value of serum fgf19 in children with biliary atresia based on a large sample.

Eligibility criteria:
inclusion criteria: * samples diagnosed as biliary atresia in children's hospital of fudan university * samples with one-year follow-up records after surgery * samples with a record of serum total bilirubin levels three months after surgery * samples with preoperative serum left（volume \> 500ul) exclusion criteria: * none

Keywords: biliary atresia fgf19
cerebello-spinal tdcs as rehabilitative intervention in neurodegenerative ataxia

Conditions: Ataxia; Spinocerebellar Ataxias; Spinocerebellar Ataxia Type 1; Spinocerebellar Ataxia Type 2; Spinocerebellar Ataxia 3; Multiple System Atrophy; Ataxia With Oculomotor Apraxia; CANVAS

Summary: neurodegenerative cerebellar ataxias represent a group of disabling disorders which currently lack effective therapies. cerebellar transcranial direct current stimulation (tdcs) is a non-invasive technique, which has been demonstrated to modulate cerebellar excitability and improve symptoms in patients with cerebellar ataxias. in this randomized, double-blind, sham-controlled study followed by an open-label phase, the investigators will evaluate whether a repetition of two-weeks' treatment with cerebellar anodal tdcs and spinal cathodal tdcs, after a three months interval, may further outlast clinical improvement in patients with neurodegenerative cerebellar ataxia and can modulate cerebello-motor connectivity, at short and long term.

neurodegenerative cerebellar ataxias represent a heterogeneous group of disabling disorders in which progressive ataxia of gait, limb dysmetria, oculomotor deficits, dysarthria and kinetic tremor are the prominent clinical manifestations. both the hereditary and sporadic forms usually present in young adulthood, and are characterized by atrophy of cerebellar or brainstem structures. currently, cerebellar ataxia lack effective disease-modifying therapies. cerebellar transcranial direct current stimulation (tdcs) is a non-invasive technique, which has been demonstrated to modulate cerebellar excitability and improve symptoms in patients with cerebellar ataxias. the present randomized, double-blind, sham-controlled study followed by an open-label phase will investigate a repetition of two-weeks' treatment with cerebellar anodal tdcs and spinal cathodal tdcs, after a three months interval, may further outlast clinical improvement in patients with neurodegenerative cerebellar ataxia and can modulate cerebello-motor connectivity, at short and long term. in addition the investigators will evaluate if tdcs intervention might improve cerebellar cognitive-affective syndrome in patients with ataxia.

Eligibility criteria:
inclusion criteria: * patients with a cerebellar syndrome and quantifiable cerebellar atrophy exclusion criteria: * severe head trauma in the past * history of seizures * history of ischemic stroke or hemorrhage * pacemaker * metal implants in the head/neck region * severe comorbidity * intake of illegal drugs * pregnancy

Keywords: transcranial direct current stimulation transcranial magnetic stimulation spinocerebellar ataxia cerebellar ataxia
social support intervention targeting patients treated for cardiac disease who experience loneliness

Conditions: Feasibility

Summary: introduction: in patients treated for cardiac disease, loneliness is known to contribute negatively to health behavior, health outcome and increase risk of cardiac and all-cause mortality. even so, in health care research, social support interventional studies targeting patients who experience loneliness is lacking. aim: to determine the feasibility of an individually structured social support intervention targeting patients treated for cardiac disease who experience loneliness. design: a feasibility study based on randomized clinical trial design with 1:1 randomization to a 6-month social support program, plus usual care (intervention) versus usual care, (i.e., regular guidelines-based follow-up). intervention: patients classified as high risk lonely according to the high risk loneliness tool will be provided with an informal caregiver in the six months rehabilitation phase following cardiac disease treatment. the informal caregiver will be designated by the patient from the existing social network or a peer, depending on patients' preferences. the core content of the intervention is through nurse consultations at baseline, one, three and six months, to enhance and reinforce the informal caregiver's competences to be a social support resource. the theoretical framework of the nurse consolations will be based on middle-range theory of self-care. outcome: feasibility will be evaluated in terms of acceptability and adherence according to predefined feasibility criteria. the preliminary effect of the intervention on patient-reported outcomes, health behaviors and health outcomes will be evaluated in the intervention and the control group at baseline, one, three, six and twelve months.


Eligibility criteria:
inclusion criteria: * patients treated for ischemic heart disease (cabg or pci), valve disease (tavr, savr), and arrhythmia (icd, pacemaker implantation or ablation) treated at rigshospitalet and classified as high risk lonely according to the high risk loneliness (hirl) tool exclusion criteria: * patients who are unable to provide written consent, therefore, patients with severe cognitive or physical dysfunction will not be approached

Keywords: loneliness social support cardiac
prognositc factors in covid-19 patients complicated with hypertension

Conditions: 2019-nCoV

Summary: there are currently no clinical studies reporting clinical characteristics difference between the hypertension patients with and without acei treatment when suffered with novel coronavirus infection in china.

at present, the outbreak of the new coronavirus (2019-ncov) infection in wuhan and hubei provinces has attracted great attention from the medical community across the country. both 2019-ncov and sars viruses are coronaviruses, and they have a large homology. published laboratory studies have suggested that sars virus infection and its lung injury are related to angiotensin-converting enzyme 2 (ace2) in lung tissue. and ace and ace2 in the renin-angiotensin system (ras) are vital central links to maintain hemodynamic stability and normal heart and kidney function in vivo. a large amount of evidence-based medical evidence shows that ace inhibitors are the basic therapeutic drugs for maintaining hypertension, reducing the risk of cardiovascular, cerebrovascular, and renal adverse events, improving quality of life, and prolonging life in patients with hypertension. recent experimental studies suggest that treatment with ace inhibitors can significantly reduce pulmonary inflammation and cytokine release caused by coronavirus infection.

Eligibility criteria:
inclusion criteria: * adult aged \>=18years old; * diagnosed with 2019-ncov. diagnostic criteria including: laboratory (rt-pcr) confirmed 2019-ncov infection; ct of the lung conformed to the manifestation of viral pneumonia. * diagnosed with primary hypertension. * criteria for severe or critical ill conditions: respiratory rate \>=30/min; or rest spo2\<=93%; or pao2/fio2\<=300mmhg. exclusion criteria: * near-death state (expected survival time less than 24 hours); * malignant tumor; * pregnancy or puerperium women; * acei contraindication * patients who refused to participant.
effectiveness and safety of 3 dosing regimens of cp-690,550 to placebo in subjects with moderate to severe chronic plaque psoriasis

Conditions: Psoriasis

Summary: the purpose of this study is to determine the effectiveness and safety, over 12 weeks, of 3 dosing regimens of cp-690,550 for the treatment of adults with moderate to severe chronic plaque psoriasis.


Eligibility criteria:
inclusion criteria: * have been diagnosed with plaque psoriasis for at least 6 months. * have plaque psoriasis covering at least 15% of their total body. * be a candidate for phototherapy or systemic treatment of psoriasis (either naïve or history of previous treatment). * be willing and able to comply with scheduled visits, treatment plan and other study procedures. exclusion criteria: * currently have non-plaque forms of psoriasis or drug-induced psoriasis. * subject cannot discontinue systemic therapies and/or topical therapies for the treatment of psoriasis and cannot discontinue phototherapy. * subject is participating in another trial using an investigational agent or procedure. * women who are pregnant or breast-feeding or considering becoming pregnant.

Keywords: dose response; pasi 75 response endpoint; subjects with moderate to severe chronic plaque psoriasis
treatment of epidemic keratoconjunctivitis with 2% povidone-iodine

Conditions: Viral Conjunctivitis

Summary: the purpose of this study is to determine the outcomes of treating epidemic keratoconjunctivitis with 2% povidone-iodine.

the study design was a prospective interventional case series. our institutional ethical committee approved the study protocol in april 2004. we performed this study between july 2004 and december 2009. during this period, there were 2 episodes of ekc epidemic. the first episode was in 2006 and the second in 2009.

Eligibility criteria:
inclusion criteria: * patients who were diagnosed with ekc at the outpatient ophthalmic unit exclusion criteria: * children younger than six years * women being pregnant or during lactation * history of allergy to povidone-iodine * prior ocular surgery * contact lens usage and chronic eye diseases with current eye medications.
healthy control population for pais-me/cfs: study to evaluate possible biomarkers and methods for examination of pais-me/cfs diagnostics in healthy volunteers

Conditions: Healthy Controls

Summary: using the data from the help study, the underlying processes of the diseases me/cfs and pais are to be researched and elucidated. the comparison of affected patients with healthy controls is intended to identify disease-specific patterns that could be related to the development or progression of the disease. the aim is to find a suitable biomarker for diagnostics and to develop therapeutic approaches.

the underlying pathomechanisms of the diseases pais and me/cfs are to be investigated and elucidated in more detail. the aim is to establish a cohort of healthy controls at our mri chronic fatigue center (mcfc). within this cohort, the measurement instruments used so far in me/cfs diagnostics will be validated. in addition, data material from this pool should be used for the statistical evaluations of various case-control studies of our center and our cooperation partners in order to find and develop a suitable biomarker for diagnostics and therapeutic approaches for pais and me/cfs.

Eligibility criteria:
inclusion criteria: * healthy control subjects without a known medical diagnosis, except: asthma, allergies, neurodermatitis, if this does not require regular medication (self-disclosure) * age: 10 - 25 years * written declaration of consent or, in the case of minors, written declaration of consent from the participants and their legal representatives exclusion criteria: * acute illnesses (e.g. infections) or major injuries * known chronic diseases (including psychological diagnoses) other than those mentioned above * surgery or blood transfusion in the last 3 months * no intake of on-demand medication (e.g. painkillers) in the last 7 days before the date of the examination * pregnancy; breastfeeding * limited legal capacity

Keywords: me/cfs post-covid biomarker
the effects of motor imagery training and physical practice on upper extremity motor function in patients with stroke

Conditions: Stroke

Summary: the aim of the study is to compare the effects of specific functional task-oriented motor imagery training combined with the bobath therapeutic approach and physical practice after imagery on upper extremity motor function in stroke patients.

motor imagery (mi) is the mental rehearsal of motor abilities to improve function. thus, imagery provides both the learning of the new movement and the improvement of the quality of movement by repeating the known activities.the investigators these neurophysiological findings obtained in recent years have popularized the use of motor imagery approach in the rehabilitation of stroke patients. 32 stroke patients aged 50-75 years will be included in the study. cases will be randomized into 2 groups. in our study, a treatment program will be applied with a physiotherapist for a total of 8 weeks, 2 days a week. the first group in the treatment program; motor imagery will be performed with the bobath therapeutic approach (bta+mi) and the second group will be physical practice of imagery activities after motor imagery with the bobath therapeutic approach (bta+mi+pp). motor imagery activity was determined as 'eating activity'. the desired goal as a result of our work; the investigators think that motor imagery training on eating activity of stroke patients and physical practice used together will improve both the achievement of eating activity and upper extremity motor function.

Eligibility criteria:
inclusion criteria: * a maximum of 24 months have passed since the stroke, * unilateral involvement, * getting a score of 21 and above in the mini mental test, * getting a score of 22 and above in the fugl-meyer test, * ability to understand and follow simple verbal commands, * stage 4 or 5 according to brunnstrom upper extremity stages, * spasticity 1 or 1+ according to the modified ashworth scale, * having signed the informed consent form. exclusion criteria: * patients with visual and hearing impairments that would interfere with work. * having pain and limitation of joint movement that may prevent performing the given tasks. * having any neurological disorder other than stroke.

Keywords: stroke motor imagery physical practice bobath therapeutic approach
effects of a floss band on ankle in stroke

Conditions: Chronic Stroke

Summary: abstract: background/objectives: stroke patients generally have balance and gait dysfunction due to decreased range of motion (rom) and muscle strength of the ankle joint. a therapist can apply a floss band to enhance rom, pain control, jumping performance, strength, myofascial release, and recovery from fatigue. this study compared the immediate effects of floss band application on ankle rom, balance, and gait ability in stroke patients.; methods: this study randomized 40 chronic stroke patients to either the floss (n = 20) or sham (n = 20) band group. outcome measures were ankle rom, weight bearing lunge test (wblt) performance, standing balance, and gait ability. outcome measures were assessed at baseline and immediately after applying the floss or placebo band.

the floss band intervention used the standard floss band technique, wrapping a floss band (lime green sanctband comprefloss™, 2" × 3.5 m; pentel, shah alam, malaysia) made of natural rubber tightly around the ankle on the affected side. it was started at the fifth metatarsal and wrapped horizontally around the metatarsals twice, in a figure eight to the medial malleolus, over the achilles tendon and the lateral malleolus three times, and around the medial malleolus again, before being passed twice from the medial mal-leolus over the achilles tendon to the lateral malleolus, forming an end knot. the participants were instructed to perform low-intensity active exercise involving ankle df and plantar flexion for 2 minutes after applying the floss band. then, the floss band was removed and the patient was asked to walk lightly on level ground for about 1 minute to allow reperfusion to normalize blood flow.

Eligibility criteria:
inclusion criteria: * diagnosed with ischemic or hemorrhagic stroke * chronic patients 6 months after stroke onset * able to walk 10 meters independently * unable to dorsiflexion the ankle on the affected side * modified ashworth scale (mas) score \< g2 for the ankle joint * adequate cognitive status mini-mental state examination (mmse) score of ≥ 23 exclusion criteria: * impaired lower extremity function due to other causes * dizziness * hemianopia, or other symptoms indicating vestibular dysfunction * serious heart disease or use of a pacemaker * unable to tolerate the floss band intervention

Keywords: floss band ankle intervention