Kornimate/medical-research-clean huggingface dataset:
different resistance training intensity prescription and monitoring methodologies: effects on strength, body composition, and well-being in survivors of breast cancer

Conditions: Breast Cancer

Summary: the goal of this clinical trial is to compare the effects of three different methods of prescribing and monitoring resistance training intensity on muscle strength, body composition, quality of life, fatigue, anxiety, and depression in breast cancer survivors.

breast cancer survival rates have significantly increased in recent years, highlighting the importance of effective interventions to address the long-term consequences of cancer and its treatments. breast cancer survivors often experience muscle weakness, changes in body composition, fatigue, and psychological distress, which can negatively impact their quality of life. resistance training has been widely recognized as a safe and effective strategy to counteract these effects, improving muscle strength, body composition, and psychological well-being. despite its benefits, the optimal method for prescribing and monitoring resistance training intensity in breast cancer survivors remains unclear. traditional methods based on one-repetition maximum (1rm) testing may not fully account for individual variations in fatigue and performance. alternative approaches, such as load-velocity relationships, allow for more precise and real-time adjustments to training intensity, potentially optimizing outcomes. this randomized controlled trial aims to compare the effects of three different methods of resistance training intensity prescription and monitoring on muscle strength, body composition, quality of life, fatigue, anxiety, and depression in breast cancer survivors. the findings will contribute to developing evidence-based exercise guidelines, enhancing rehabilitation strategies and overall well-being in this population.

Eligibility criteria:
inclusion criteria: * to be \>18 years old. * to have a breast cancer diagnosis. * to have finished chemotherapy, radiotherapy and/or surgery up to 10 years prior to the beginning of the study. exclusion criteria: * to present metastatic breast cancer. * to have a planned surgery for breast reconstruction within three months after the start of the study. * to present any absolute contraindication for exercising.

Keywords: resistance training muscular strength health-related quality of life exercise intensity breast malignancy
scheme of limb warming blanket combined with dexmedetomidine

Conditions: Spine Surgery; Postoperative Delirium and Chills

Summary: objective: to observe the clinical effect of lower limb warming blanket combined with dexmedetomidine (dex) in preventing postoperative delirium (pod) and chills in elderly patients undergoing spinal surgery. methods: a total of 160 elderly patients undergoing posterior spinal surgery under general anesthesia were selected and divided into control group (group n), heating group (group t), dex group (group d) and heating combined with dex group (group td) according to the random number table method, 40 cases in each group. t group and td group routine insulation and lower limb heating blanket. dex was injected in group d and group td. the dosage of anesthetics, the changes of body temperature and heart rate at different time points during operation, and the occurrence of postoperative chills and pod were compared among the groups.


Eligibility criteria:
inclusion criteria: * age: between 65-80 years old; * american society of anesthesiologists (asa) grade ii-iii; * normal body temperature before operation; * the operation time was 2-4 hours exclusion criteria: * preoperative fever or hypothermia (body temperature≥37.5 ℃ or≤35.5℃ on the day of operation); * body mass index (bmi) \>30 kg/m2; * the existence of heart, brain, lung, kidney and other important organs and circulatory system, respiratory system, immune system, central nervous system diseases; * patients who had taken antipsychotic drugs or β-blockers before surgery would have a greater impact on intraoperative body temperature and other patients who could not effectively cooperate with this study; * patients with operation time more than 5 hours

Keywords: elderly spinal surgery delirium and chills
a study of xb628 in participants with recurrent advanced or metastatic solid tumors

Conditions: Solid Tumor; Advanced Solid Tumor; Metastatic Solid Tumor; Immune Sensitive Tumor

Summary: this is a phase 1, first-in-human, open-label, dose-escalation study of xb628, a first-in-class bispecific antibody natural killer (nk) cell engager that targets nk group 2 member a (nkg2a), an inhibitory receptor on nk cells, and programmed cell death-ligand 1 (pd-l1).

this study consists of a dose-escalation stage. the dose-escalation stage is designed to determine the maximum tolerated dose (mtd) and/or recommended dosage(s) for expansion (rde\[s\]) of xb628 as a single agent.

Eligibility criteria:
inclusion criteria: * eastern cooperative oncology group (ecog) performance status of 0 to 1. * minimum life expectancy of ≥ 12 weeks. * have a recurrent advanced or metastatic solid tumor that is histologically or cytologically confirmed. * adequate organ and marrow function. * not amenable to curative treatment with surgery or radiation. * received at least 1 line of prior systemic anticancer therapy in the recurrent or metastatic setting. * acceptable alternative therapy was received, refused, intolerable, or no longer effective. * capable of understanding and complying with the protocol requirements and provide signed informed consent according to the protocol and local requirements. exclusion criteria * primary brain tumors or known active brain metastases. * major surgery (eg, gastrointestinal surgery, removal or biopsy of brain metastasis) within 4 weeks before the first dose of study treatment. * received radiation therapy within 1 week before the first dose of study treatment or clinically relevant ongoing complications from prior radiation therapy. * received prior therapy targeting nk cells (eg, monalizumab). * a woman of childbearing potential has a positive serum pregnancy test within 7 days prior to study treatment.

Keywords: xb628 solid tumor advanced solid tumor metastatic solid tumor immune sensitive tumor pd-l1
obstructive sleep apnea in the absence of metabolic syndrome

Conditions: Obstructive Sleep Apnea

Summary: obstructive sleep apnea (osa) is commonly associated with factors that increase cardiovascular risk, including metabolic syndrome (ms). there is a lack of well-controlled clinical studies investigating the independent effects of osa in the development of cardiovascular disease, especially evaluating jointly mechanisms involved in these disorders such as inflammatory response, oxidative stress and vascular changes. the investigators hypothesized that in the absence of mets, the mechanisms involved on cardiovascular consequences in osa patients would be less important. the purpose of this study is to analyze the effects of osa in the absence of ms, on inflammatory, oxidative stress and vascular markers; to verify the influence of excessive daytime sleepiness (eds) on the same parameters; and additionally verify the effects of nasal continuous positive airway pressure (ncpap)in theses parameters.


Eligibility criteria:
inclusion criteria: * male subjects * apnea-hypopnea index \> 15/h (osa group) * apnea-hypopnea index \< 5/h (control group) exclusion criteria: * body mass index (bmi) \> 30 kg/m2 * age \> 60 years * chronic obstructive pulmonary disease * cardiac diseases * diabetes mellitus * metabolic syndrome according to modified national cholesterol education program adult treatment panel iii criteria * previous osa treatment

Keywords: obstructive sleep apnea inflammation oxidative stress arterial stiffness
enhancing education regarding living donor transplant among kidney transplant candidates

Conditions: Kidney Transplant; Living-Donor Kidney Transplant; Chronic Kidney Disease; End-stage Renal Disease

Summary: the primary purpose of this study is to test different methods by which kidney transplant centers can educate potential transplant candidates about living donor kidney transplant (ldkt). the most effective ways to educate kidney transplant candidates about ldkt remain unclear. the goal is to determine, among a diverse cohort of potential kidney transplant candidates, whether a transplant center-based intervention will increase understanding of the opportunities for and process, risks, and benefits of living kidney donation and ldkt. the investigators hypothesize that kidney transplant candidates' understanding of living kidney donation and ldkt will be increased by interventions implemented at the transplant center on the day of transplant evaluation. the investigators propose a single-center, 2-arm, cluster-randomized, controlled trial to compare the effects of two educational strategies upon transplant candidates' understanding of living kidney donation and ldkt: 1. usual transplant education implemented by the transplant center, on the day of the transplant evaluation (standard care); and 2. intensive initial transplant education implemented on the day of the transplant evaluation. intensive initial transplant education will utilize videos of living donors' experiences as well as a session with a trained transplant educator, who will focus upon living donation education. one week after the transplant evaluation day and 3 months later, the investigators will assess transplant candidates' knowledge of ldkt (using questionnaires), identify correlates of increased understanding of ldkt, and assess racial/ethnic differences in the understanding of ldkt.


Eligibility criteria:
inclusion criteria: * appear for initial kidney transplant evaluation at saint barnabas medical center * 18 years of age or older * able to provide informed consent * able to speak, hear, and understand english exclusion criteria:
physiological adaptations to simulated intermittent altitude on human health and performance

Conditions: Altitude Hypoxia

Summary: the investigators expect to find that different intensity and altitude exposure levels will show what kind of intermittent exposure protocol is more beneficial to athletes and healthy individuals that experience acute exposure to altitude during exercise. this may furthermore be related to acute altitude exposure for recreational exercise use as well.


Eligibility criteria:
inclusion criteria: * 18-70 years of age, * history of good health, * generally active to competitive athletes. exclusion criteria: * history of cardiac or pulmonary disease, * not currently active, * unable to exercise or meet study requirements (e.g., number of sessions), * live at altitude (\>2,100m or 7,000ft).
open-label pilot study of the efficacy and safety of vusion ointment for the treatment of intertrigo

Conditions: Intertrigo

Summary: the purpose of this study is to determine if people with moist, red, patches on their skin in body folds would benefit treatment of those areas with an fda-approved drug called vusion.

intertrigo is an inflammatory condition of skin folds, induced or aggravated by heat, moisture, maceration, friction, or lack of air circulation. it is typically chronic with insidious onset of itching, burning, and stinging within the affected skin folds. intertrigo frequently worsened or colonized by infection, which most commonly is candidal but also may be bacterial, fungal, or viral. the etiology of diaper dermatitis shows significant overlap with that of intertrigo. vusion ointment, a highly effective treatment for diaper dermatitis, has been used by physicians for the treatment of intertrigo; however, there is a paucity of data in the literature regarding the use of vusion ointment in this indication. this study is the first to formally investigate the efficacy and safety of vusion ointment for the treatment of intertrigo.

Eligibility criteria:
inclusion criteria: * evidence of intertrigo exclusion criteria: * pregnancy * use of systemic or topical antifungal or corticosteroid treatment in the previous 14 days or during the 3-month treatment period * allergy of sensitivity to vusion * undergoing warfarin anticoagulation * alcohol or drug abuse * investigator determines they cannot particpate * history of non-compliance or poor cooperation * participation in an investigaitonal drug study within 30 days of baseline visit

Keywords: intertrigo vusion
effect of hatha yoga on pulmonary function

Conditions: Healthy

Summary: the goal of this clinical trial is to to investigate the acute and chronic effects of a four-week hatha yoga (hy) exercise program with different durations (60 min and 30 min) on pulmonary function in sedentary young individuals.. the main questions it aims to answer are: • does a four-week hatha yoga (hy) more effective than 30 min of a four-week hatha yoga (hy) and the control group in improving the pulmonary function? researchers will compare a four-week of 60 min duration hatha yoga (hy) , 30 min duration of hy and control to see the differences in the pulmonary function among high school sedentary students participants will: participants will be randomly assigned to one of three groups: 1. 60-minute hatha yoga group (60mhy, n=21) 2. 30-minute hatha yoga group (30mhy, n=21) 3. control group (cg, n=21)

objective: to investigate the acute and chronic effects of a four-week hatha yoga (hy) exercise program with different durations (60 minutes and 30 minutes) on pulmonary function in sedentary young individuals aged 15-16 years. study design: randomized controlled trial (rct) participants: • sample size: 52 sedentary individuals inclusion criteria: * high school adolescence * showed sedentary lifestyle (defined as not participating in regular physical activity for at least 6 months. exclusion criteria: * any known history of pulmonary, cardiovascular, or musculoskeletal conditions that would contraindicate exercise, * participation in any other exercise program during the study period * obesity (bmi \> 25.00) * participants who are in medication that stimulate the heart of medication such as antibiotic use were excluded from the study randomization: participants will be randomly assigned to one of three groups: 4. 60-minute hatha yoga group (60mhy, n=21) 5. 30-minute hatha yoga group (30mhy, n=21) 6. control group (cg, n=21) intervention: * 60mhy group: participants will undergo a 60-minute hatha yoga session twice a week for four weeks. * 30mhy group: participants will undergo a 30-minute hatha yoga session twice a week for four weeks. * control group: participants will receive information about physical activity guidelines but will not engage in any structured yoga exercise during the study period. outcome measures: • primary outcome: pulmonary function measured by spirometry.

Eligibility criteria:
inclusion criteria: * high school adolescence * sedentary lifestyle (defined as not participating in regular physical activity for at least 6 months. exclusion criteria: * any known history of pulmonary, cardiovascular, or musculoskeletal conditions that would contraindicate exercise, * participation in any other exercise program during the study period * obesity (bmi \> 25) * participants who are on medication that stimulates the heart of medication such as antibiotic use were excluded from the study

Keywords: pulmonary function yoga students exercise duration
hypertonic lactate after cardiac arrest

Conditions: Cardiac Arrest; Ischemia Reperfusion Injury; Anoxic Brain Injury

Summary: the study is intended to test the hypothesis that sodium lactate infusion after resuscitation from a cardiac arrest will decrease the magnitude of brain damage, as measured by the serum biomarker concentration of nse.

background: in resuscitated patients after cardiac arrest, ischemic brain injury and cardiac depression due to the reperfusion injury are accountable for high mortality rate and poor outcome. hypertonic sodium lactate (hsl) solutions have been proven to be safe in healthy volunteers and they have shown some benefits in patients with traumatic brain injury and those with myocardial ischemia and could decrease the burden of hypoxic lesions in these organs. the aim of this phase ii study is to investigate whether hsl administration could reduce organ damage related biomarkers in serum and if the administrations of these solutions is safe and feasible in resuscitated patients after cardiac arrest. design: an investigator initiated, randomized, controlled, open label phase ii clinical trial to test the safety and efficacy of the infusion of hsl in resuscitated patients after cardiac arrest admitted to the hospital. after resuscitation from ca, comatose patients will be screened for eligibility and randomized to receive either study treatment as hsl 1m infusion for 24h or standard of care. expected outcomes: this controlled trial will assess the safety and efficacy of the 1m hsl infusion in a cohort of comatose resuscitated patients after cardiac arrest. the results of this trial may provide useful information for a larger phase iii clinical trial.

Eligibility criteria:
inclusion criteria: * age \> 18 years old * sustained (\> 20 minutes) return of spontaneous circulation (rosc) * comatose (gcs \< 9) * time to rosc \> 15' exclusion criteria: * protected categories (pregnant women) * anticipated withdrawal of support within 24 hours * traumatic cause of cardiac arrest * body weight at admission \> 120kg

Keywords: sodium lactate cerebral metabolism
families taking control (ftc): family-based problem-solving intervention for children with sickle cell disease

Conditions: Sickle Cell Disease

Summary: this study aims to develop an effective, brief, family-based intervention targeting quality of life and school functioning for youth with sickle cell disease. utilizing a randomized, delayed control group intervention methodology, the present study will systematically document the effectiveness of a family-based, one-day intervention plus booster phone calls to improve quality of life and increase school functioning for children with sickle cell disease transitioning to school and their families.

families taking control-school-age intervention (ftc) will provide education and problem solving training for disease management and school functioning. in 4 sessions offered over the course of one day, families (patient, caregivers, and school-age siblings) will work together and individually to learn and apply the problem solving skills training model to relevant examples and family-specific problems, culminating in an outline of family goals to target after the intervention. the three booster phone calls will provide support to families in implementing the problem-solving model by addressing and refining goals and trouble-shooting barriers to implementation. children and caregivers completed measures at baseline (prior to intervention participation) and 6 months later.

Eligibility criteria:
inclusion criteria: english speaking, treated at one of two participating sickle cell centers - exclusion criteria: severe developmental delay or children/caregivers with severe psychopathology that would adversely affect their ability to participate -
nutrition and exercise study to understand metabolic syndrome

Conditions: Metabolic Syndrome; Obesity; Insulin Resistance

Summary: the purpose of this study is to measure the metabolic and behavioral effects of a 12-week yoga program coupled to health education (hed) compared to hed alone.

the purpose of this study is to measure the metabolic and behavioral effects of a 12-week yoga program coupled to health education (hed) compared to hed alone. in a randomized clinical trial of 90 patients (45 patients per arm), investigators will measure the effects of the two interventions on ir, htn, dysplidemia, and body composition (see figure 1. study diagram). subjects will be scheduled for outcome assessment at baseline, 12 weeks, and 24 weeks. in addition, investigators will collect data at baseline and 12 weeks on self-efficacy, stress, mindfulness, and mood. as a sub-study to the randomized controlled trial, investigators will measure the aerobic intensity of the yoga to estimate the dose of physical exercise provided by the yoga (n=10). subjects willing and eligible to participate in the rct will receive written consent. consented subjects will be randomized to either 12 weeks of yoga with hed versus hed alone. subjects randomized to yoga will receive 30 to 45 minutes of weekly yoga instruction, followed by 30 to 45 minutes of hed. subjects will receive written instructions for home yoga practice and lifestyle changes based on hed. subjects randomized to hed alone will receive a weekly standardized hed curriculum which will be attention and time matched to the yoga with hed arm.

Eligibility criteria:
inclusion criteria: * elevated waist circumference (men greater than 102cm; women greater than 88cm) * impaired fasting glucose (100-125 mg/dl) * elevated blood pressure (systolic ≥130 and/or diastolic ≥ 85) * dyslipidemia (triglycerides ≥150 and/or hdl≤ 40 for men; 50 for women) * age ≥ 18 * english speaking exclusion criteria: * currently taking blood pressure medications, oral diabetic medication or insulin, or lipid medication * systolic blood pressure ≥160 and/or diastolic ≥100 * unstable cardiac disease e.g. angina, life threatening arrhythmia * lung disease requiring oxygen supplementation at rest or with ambulation * history of dementia or cognitive impairment * uncontrolled psychiatric disorders, such as major depression or psychosis * current participation in a mind-body practice/program
inhospital resuscitation: incidence, causes and outcome

Conditions: In-hospital Cardiac Arrest

Summary: define the frequency and survival pattern of cardiac arrests in relation to the hospital day of event and etiology of arrest.

define the frequency and survival pattern of cardiac arrests in relation to the hospital day of event and etiology of arrest. the study aims to evaluate the outcome of in-hospital cardiac arrests, focusing on the relationship between etiology and outcome and, in particular, in relation to the length of hospitalization prior to the cardiac arrest. the aimed to sought to test the hypothesis that cardiac arrests occurring after longer hospitalizations were associated with lower survival rates and worse neurological outcomes compared to shorter hospitalizations.

Eligibility criteria:
inclusion criteria: * cases where the emergency help team is called exclusion criteria: * absence of informed consent * lack of data records of patients

Keywords: cpr cardiac arrest inhospital