Kornimate/medical-research-clean huggingface dataset:
study of antenatal and postnatal data of anorectal malformations diagnosed at montpellier university hospital over a 10-year period (2010-2020)

Conditions: Anorectal Malformations

Summary: objective : anorectal malformations (arms) are part of a spectrum of malformations due to an abnormal separation between the urogenital and digestive tracts during embryonic life. the prevalence of arm is 1/2000 - 1/5000 live births, making it a relatively common malformation. the impact of an arm depends mainly on the type of malformation, which can be difficult to evaluate in the antenatal period, and whether it is isolated or associated (50-80%) with other malformations or genetic syndromes. only 1 to 16% of arms are diagnosed in the antenatal period. the objective of this study is to compare cases of prenatal diagnosis of arm, cases of postnatal diagnosis of arm with other antenatal ultrasound abnormalities, and those with normal antenatal ultrasound, in terms of management and functional prognosis, to identify ways to improve prenatal counseling. materials and methods : in this retrospective monocentric study, the investigators have included all fetuses and newborns born between january 2010 and september 2020 with anorectal malformations, diagnosed from postnatal radiological examinations and surgical or autopsy reports at the university hospital of montpellier. the krickenbeck classification was used to classify the arms and to assess the functional prognosis.


Eligibility criteria:
inclusion criteria: * fetuses and newborns born between january 2010 and september 2020 with anorectal malformations * diagnosed from postnatal radiological examinations and surgical or autopsy reports at the university hospital of montpellier. exclusion criteria: * foreign-born patient * anorectal malformation associated with an abdominal wall defect
clinical evaluation of the zynex blood volume monitor (cm-1500) in healthy male adult subjects during a blood draw

Conditions: Blood Loss; Healthy

Summary: zynex's blood volume monitor (bvm) is a non-invasive monitoring device to monitor blood volume and blood loss of a patient during surgery, post operatively and/or in recovery. this monitoring device will identify baseline blood volume and relative changes in blood volume using a specific algorithm to compare and review data already monitored during surgery, displaying blood volume and blood loss in real-time.


Eligibility criteria:
inclusion criteria: * written informed consent * male, 18-65 years of age * subject is suitable for a blood draw of a pint of blood * weighs at least 110 pounds exclusion criteria: * subject has a heart condition that may interfere with the zynex cm-1500 * subject has unstable or untreated heart disease * subject has been diagnosed with chronic fatigue syndrome * subject is taking coumadin (warfarin), heparin, or other prescription blood thinners for at least 7 days prior to blood draw * subject donated blood within 8 weeks prior to blood draw * subject has high or low blood pressure on the day of blood draw * subject hemoglobin \< 12.5 g/dl

Keywords: blood loss healthy volume to evaluate the ability of the zynex bvm to non-invasively detect blood loss in healthy subjects during a blood draw.
efficacy of single incision (embryonic notes) laparoscopic colorectal surgery

Conditions: Colorectal Cancer

Summary: laparoscopic colon surgery has been performed widely. as a minimal invasive approach, single incision (embryonic notes) colon surgery has been attempted. however, there are not sufficient evidences for single incision colon surgery in colon cancer. the investigators are researching the efficacy and safety of single incision laparoscopic sigmoidectomy in sigmoid colon cancer.

after several randomized clinical trials, laparoscopic colon surgery has been performed widely. as a minimal invasive approach, single incision (embryonic notes) colon surgery has been attempted. several studies reported the feasibility of single incision colon surgery.however, there are not sufficient evidences for single incision colon surgery, especially in colon cancer. the investigators are researching the efficacy and safety of single incision laparoscopic sigmoidectomy in sigmoid colon cancer. harvested numbers of lymph node will be assessed for the efficacy and postoperative morbidity and mortality will be assess for the safety.

Eligibility criteria:
inclusion criteria: * patients should sign a written informed consent * age between 18-80 * patients have sigmoid colon cancer that was proved by pathology * adequate bone marrow function hb ≥ 10g/dl (after treatment for simple iron deficiency anemia) wbc ≥ 3,000/mm3 plt ≥ 100,000/mm3 * adequate kidney function creatinine ≤ 1.5 mg/dl * no remarkable evidence of heart dysfunction and lung dysfunction exclusion criteria: * distant metastasis * tumor diameter \> 5 cm * other organ invasion * intestinal obstruction and stent insertion status * patient was used steroid * patients undergo emergency surgery with multiple symptoms * other organ cancer history (except who had radical excision for skin cancer) * presence of other serious disease * mentally ill patients * legally unable to participate in clinical trial * lactating or pregnant women * patients who will obviously fail to regular follow-up visit or will be off study voluntarily * not eligible to participate for other reasons by doctor's decision

Keywords: colorectal cancer, laparoscopic surgery
transferability and cost-effectiveness of prospect in surgical trainees

Conditions: Vascular Disease

Summary: to design, validate and prove cost-effectiveness of a comprehensive endovascular simulation curriculum consisting of cognitive and psychomotor skills training for endovascular management of symptomatic vascular disease in the lower limbs.

the main goal is to design a comprehensive endovascular simulation curriculum consisting of cognitive and psychomotor skills training for endovascular management of symptomatic vascular disease in the lower limbs (rutherford classification 2-5; stenosis or occlusion in the iliac, superficial femoral and popliteal arteries). the curriculum will consist of e-learning, video-based learning and simulation exercises on the virtual reality simulator on which an endovascular procedure will be simulated. skills transferability to real life practice will be verified by means of a rct. in this rct the investigators will compare the cognitive knowledge and technical performance of curricular trained surgical trainees with conventionally trained trainees during treatment of patients under supervision. the hypothesis states that surgeons trained within the prospect curriculum will show improved technical knowledge of endovascular treatment of atherosclerotic disease in the iliac, superficial femoral and popliteal arteries and will demonstrate increased technical proficiency in the angiosuite in comparison with surgeons who received only conventional training. subjects will be surgical trainees (n=32). they will be randomized into a three groups: a control group (n=11), a group that only has access to e-learning (n=10) and a prospect group (n=11). both groups will continue their traditional clinical education and the prospect group will additionally be trained within this endovascular curriculum. the investigators hope that this study may ultimately lead to an improvement in the quality of patient care by standardizing competencies of endovascular operators in training and practice. additionally a cost-effectiveness analysis of prospect compared to traditional training modalities will be executed. a successful training program is expected to lead to a shortening of the learning curve, reduction in number of errors during real life procedures and more efficient use of hybrid angio suites. the financial impact of potentially shorter duration of endovascular interventions will be studied and compared to time investment and additional costs associated with stepwise, supervised training using vr simulators.

Eligibility criteria:
inclusion criteria: * surgical trainee * knowledge and technical skill level evaluated * demographics questionnaire and general mcq test completed * 2 endovascular simulated exercises completed after familiarization with the simulator exclusion criteria: -
effect of banana blossom on breast milk volume in mothers of preterm newborns

Conditions: Preterm Birth; Postpartum Women

Summary: the purpose of this study is to assess the effect of banana blossom in increasing breast milk volume


Eligibility criteria:
inclusion criteria: * postpartum women of preterm newborns exclusion criteria: * postpartum women with contraindication for breast feeding such as hiv, herpes zoster at breast, infected wound at breast. * postpartum women with preeclampsia, diabetes mellitus, postpartum hemorrhage. * postpartum women with allergy to banana blossom. * postpartum women with previous breast surgery or nipple surgery. * postpartum women who smoking. * preterm newborns with unstable conditions.
morphological detection of liquid-based thin-layer film-making fungi for fungal vaginitis in multiple hospitals

Conditions: Vaginitis

Summary: the purpose of this study is to compare the results of different detection methods for non-gestational fungal vaginitis (vvc), and to evaluate the significance of different fungal states in the results for diagnosis and treatment.

the study was divided into two phases: in the first phase, the vaginal secretions of 1000 enrolled patients with fungal vaginitis were detected with 3/4 different methods, and the sensitivity, specificity and consistency of these methods were compared; in the second stage, 1000 patients from the first stage were selected to meet the follow-up stage and divided into two groups. the test of follow-up fungal culture and fluorescence morphological detection of liquid-based thin-layer film-making fungi were performed periodically. at last, the applicant will analyze the data, write the paper and publish the article.

Eligibility criteria:
inclusion criteria: * 1. samples from outpatient or inpatient clinics to be tested for fungal vaginitis. * 2. a sample of one or more of the following characteristics. 2.1 symptoms: vulva pruritus, burning pain, but also accompanied by pain in urine and sexual pain and other symptoms; leucorrhea increased. 2.2 physical signs: vulva flushing, edema, visible scratches or chaps, white membrane attached to the inner side of the labia minora and the vaginal mucosa, more white bean residue like secretions can be seen in the vagina, which can be curd. * 3. the samples are vaginal secretions from the female body. each sample should be the amount on one swab. * 4. the sample is not in menstrual period. * 5. the sample subjects did not have vaginal irrigation, medication or sexual intercourse within 3 days. exclusion criteria: * 1. cases with incomplete specimen collection; * 2. mixed vaginitis cases; * 3. abscission cases with incomplete follow-up.

Keywords: fluorescence morphological liquid-based thin-layer film-making fungal vaginitis
anticoagulation, vitamins, and endothelial function

Conditions: Cardiovascular Diseases

Summary: determine whether low or high dose b vitamin therapy will lower homocysteine and thrombomodulin in patients anticoagulated with warfarin.

we hypothesize that 1) both high and low dose b vitamin therapy will lower homocysteine in patients anticoagulated with warfarin and 2) high dose b vitamin therapy will lower thrombomodulin in patients anticoagulated with warfarin. to accomplish these specific aims, we proposed a double- blind randomized controlled trial of 6 months duration comparing 2 different multivitamin regimens differing only in the doses of the following 3 vitamins. the multivitamin for the control group has no folic acid, b2, b6, or b 12. the multivitamin for the intervention group has 5 ing folic acid, 1.7 mg b2, 100 mg b6, and i mg b12. participants age 50 and older, 150 in each group, are being recruited from the anticoagulation clinics at the baltimore vamc and neighboring centers. clinical and risk factor information is being obtained through a face-to-face interview. blood is being drawn for analyses of homocysteine and vitamin levels (university of colorado health science center) and thrombomodulin (baltimore vamc hemostasis and thrombosis laboratory). data analysis will be conducted according to the "intention to treat" principle using ordinary least squares regression models.

Eligibility criteria:
males and females ages 50 years or greater on warfarin therapy for at least 3 months no active inflammatory process no physician prescribed b vitamins excluded - women of child-bearing age

Keywords: geriatrics vitamin b complex thrombomodulin anticoagulants
tacrolimus ointment interest (protopic ®) in the maintenance treatment of severe seborrheic dermatitis

Conditions: Severe Seborrheic Dermatitis

Summary: seborrheic dermatitis is a chronic inflammatory dermatological disease, evolving by relapses, affecting mainly the face and scalp. it would be important to have a maintenance treatment for severe forms of seborrheic dermatitis witch is both effective and relatively well tolerated to reduce the frequency of relapses, prolong remissions obtained after attack treatment and reduce the use of topical steroids.


Eligibility criteria:
inclusion criteria: * in phase 1: attack treatment (open) 1. over the age of eighteen patient, 2. seborrheic dermatitis severe, 3. participation with an informed consent, 4. women of childbearing age in effective contraception for the duration of the study or postmenopausal women. * in phase 2: phase 2: "randomization" (blind) 1. patient achieved a complete or almost complete clinical remission after the initial treatment, 2. known immunodeficiency (hiv patient receiving chemotherapy) or immunosuppressive therapy or biotherapy, 3. patient taking regular systemic corticosteroids at a dose\> 20 mg / day 4. erythematous lesions with topography other than the face and evocative scalp psoriasis (elbows, knees ...), by referring to the possibility that the facial lesions correspond to lesions sebopsoriasis, 5. woman pregnant, nursing or in childbearing potential without effective contraception, 6. man wishing to have a child during the study period, 7. ultra violet (uv) phototherapy or usual realization of uv sessions aesthetic purposes, 8. seborrheic dermatitis symptomatic of an underlying disease known or revealing 9. history of cancer or lymphoma, 10. progressive cancer or lymphoma, 11. seborrheic dermatitis exclusively affecting the scalp, 12. known allergy to one-component products study , 13. malnourished patient or sick history of chronic pancreatitis by a suspect to deficiency dermatitis, 14. participation in a clinical trial on the seborrheic dermatitis in the previous 90 days, 15. patient with lesions considered potentially malignant or pre-cancerous, 16. patient with abnormal skin barrier. exclusion criteria: * in phase 1: attack treatment (open) 1) patient had already been treated with protopic ® for seborrheic dermatitis, * phase 2: "randomization" (blind) 1) patient with no complete or almost complete clinical remission after the initial treatment,

Keywords: local immunosuppressive maintenance therapy
cabozantinib post first-line immuno-oncology checkpoint inhibitor containing combination

Conditions: Advanced Renal Cell Carcinoma (aRCC)

Summary: this study will collect real-world data for the new treatment pathways for all patients with advanced renal cell carcinoma (arcc) who were treated with a 1l io (first-line, immuno-oncology checkpoint inhibitor) combination therapy and progressed to a 2l treatment with particular focus to understanding where cabozantinib is prescribed after 1l io containing combination therapy.


Eligibility criteria:
inclusion criteria: * patients with a diagnosis of arcc. * patients aged ≥18 years at arcc diagnosis treated with a 1l io containing combination therapy who have progressed to a 2l treatment. exclusion criteria: * patient's hospital medical records are unavailable for review; * patients have started a 2l treatment as part of a renal carcinoma treatment (rct).
improving gait and balance in children with hemiplegic cerebral palsy: gait myoelectric stimulator study

Conditions: Hemiplegic Cerebral Palsy

Summary: this research study will see if electrical stimulation increases heel strike (heel hits the floor first when walking), decreases limp, helps muscle contraction, and improves balance in children with a hemiplegic leg. an experimental electrical stimulation device called the gait myoelectric stimulator (gmes) will be used to stimulate the shin and calf muscles.

physical therapists focus on improving gait and balance in children with hemiplegic cerebral palsy (hcp). functional electrical stimulation (fes) has the potential to improve strength and functional gait for children with hcp. the investigators hypothesize that a new fes system stimulating the dorsiflexor (df) and plantarflexor (pf) muscles alternately at the correct time during gait, would lead to a significant improvement (p\<.05) in foot contact, gait symmetry and balance, compared to 12 weeks of a healthy lifestyle program called 5210.

Eligibility criteria:
inclusion criteria: * children who are: 1. are age 5-18 years 2. have been walking independently (no walker or cane) for at least 18 months. 3. use co-contraction of df and pf during walking based upon surface electromyography. 4. have a diagnosis of spastic hemiplegic cp, gross motor function classification system (gmfcs) levels i-ii exclusion criteria: * children who: 1. have passive ankle range \<5 df or \< 10 pf with hip and knee extended. 2. report uncontrolled seizures. 3. had orthopedic surgery (for example heel cord or hamstring lengthening) 4. have used tone reducing medications (botox, baclofen) in the last 6 months. 5. wear ankle foot orthoses that limit df/pf motion. 6. have low motivation/tolerance for electrical stimulation. 7. have parents/caregivers who are not able or willing to assist with the protocol for 6 months. 8. have low tolerance to electrical stimulation in screening process.
vytorin as strategy to reduce dislipidemia in adults (0653a-148)

Conditions: Hyperlipidemia

Summary: this study is intended to allow physicians to check the superior clinical efficacy of vytorin compared to atorvastatin, as the most adequate therapy using the atp-iii goals achievement and cardiovascular risk reduction in adult patients with dislipidemia.


Eligibility criteria:
inclusion criteria: * patients who voluntary accept to participate in the study after been informed by the doctor and signed the informed consent form. exclusion criteria: * any another kind of contraindication for use of statins * hypersensitivity to any of the active ingredients * increased serum hepatic enzymes (over 3 times only) * patients with severe hepatic insufficiency * women who are pregnant or potentially pregnant
association between the prevalence of cardiovascular risk factors and new use of testosterone

Conditions: Hypogonadism

Summary: we will investigate if testosterone is preferentially given to patients at higher risk of cardiovascular events. if this is the case, then observational studies may be prone to selection bias resulting in overestimation of the cardiovascular risk associated with testosterone when compared to a healthier population not taking testosterone


Eligibility criteria:
inclusion criteria: - all male individuals in the source population with a first testosterone use during the study period will be included as cases. the date of the gp consultation associated with the first testosterone prescription will be designated as the index day. exclusion criteria: - patients of less than 18 years on the index day, with less than 2-year contribution to the cprd-hes link before the index day, or with use of testosterone before the study period will be excluded from the group of cases.

Keywords: risk factors predicting the initiation of testosterone use
paediatric spinal cord injury and long-term social outcomes.

Conditions: Spinal Cord Injuries

Summary: to provide the overall quality of life (qol), activity and participation values for adults with paediatric onset spinal cord injury (sci), stratified by injury level, neurological status and compare it with matched controls with adults with adult-onset sci.

evidence obtained from adult studies demonstrate that sci can be a devastating experience that may result in reduced independence and change one's ability to participate in meaningful roles and activities. sadly, there is a paucity of similar studies into paediatric onset sci. the profile of paediatric patients with sci is different from adults and their long-term wellbeing outcomes are not well researched. maximizing activity and participation following sci is an important aspect of rehabilitation. community integration is a long process that might take months to years after discharge from hospital after the initial injury. after discharge from hospital the subsequent management is done by community team comprising of physio and occupational therapists who are pivotal in supporting re-engagement in social activities. there is a need for thorough analysis regarding the social outcomes of adults living with paediatric onset sci. quality of life, or life satisfaction, is arguably the most important outcome for children and adolescents with scis. this outcome may be the key to assessing the success of our treatment pathways and will allow us to target the resources available for rehabilitation to maximize the effects of rehabilitation programs. there are large gaps in the literature regarding paediatric scis. clinicians often struggle to give informed answers to questions such as: * will a child with sci experience good quality of life in adulthood? * is there a difference in social activity and participation between adult onset and paediatric onset injuries? * what helps social activity and participation of sci patients? * is tetraplegia worse than paraplegia for social participation? * does social participation affect quality of life? * where can we target resources in rehabilitation program? this study aspires to address these questions by conducting this questionnaire study to understand the factors that affect social participation. this will enable to highlight areas to target future resources for rehabilitation programmes.

Eligibility criteria:
inclusion criteria: * age 18- 60 years * sci for over 5 years duration exclusion criteria: * patients unable to speak and understand english * patients not able to speak on phone * patients with intellectual disability affecting their ability to speak without aids. * cauda equina syndrome