Kornimate/medical-research-clean huggingface dataset:
the study on the efficacy and safety of lactobacillus johnsonii in combination with capeox and pembrolizumab for the treatment of mss/pmmr metastatic colorectal cancer.

Conditions: Metastatic Colorectal Cancer (CRC)

Summary: the goal of this clinical trial is to verify the effectiveness and safety of lactobacillus johnsonii in combination with capeox and pembrolizumab for the treatment of mss/pmmr metastatic colorectal cancer (crc). the main questions it aims to answer are: ① to verify the effectiveness of lactobacillus johnsonii in the treatment of mss/pmmr type metastatic colorectal cancer (mcrc) who have failed the standard regimen of chemotherapy; ② to explore the safety of lactobacillus johnsonii in the treatment of mss/pmmr type metastatic colorectal cancer (mcrc) who have failed the standard regimen of chemotherapy. participants who meet all the inclusion criteria will be enrolled in the study and randomly assigned in a 1:1 ratio to either the capeox + pembrolizumab + placebo group or the capeox + pembrolizumab + lactobacillus johnsonii group.


Eligibility criteria:
inclusion criteria * ages between 18 and 75 years old; * pathologically confirmed mss or pmmr colorectal adenocarcinoma (pcr method, with 0 or 1 locus unstable; or immunohistochemical method, with expression of mlh1/msh2/msh6/pms2 proteins); * patients who have failed standard first- and second-line treatments (including capeox ± targeted therapy, folfox ± targeted therapy, 5-fu/lv ± targeted therapy); ④ radiological imaging indicates distant metastases throughout the body, considered as unresectable lesions; ⑤ willingness to comply with the study visit schedule, as well as the prohibitions and restrictions stipulated in this agreement. exclusion criteria * use of antibiotics within 4 weeks prior to treatment; * concurrent immunodeficiency diseases (such as hiv or post-transplantation status) or receipt of high-dose systemic corticosteroid therapy or any other form of immunosuppressive therapy within the last 4 weeks; * concurrent malignancies in other organs; ④ concurrent active autoimmune diseases (i.e., requiring corticosteroids or immunosuppressant medications); * concurrent active infections requiring systemic treatment; ⑥ concurrent severe systemic diseases, diseases of vital organs such as the heart, lungs, and brain, liver and renal insufficiency, among others; * participation in other drug studies within 3 months prior to treatment or inability of the patient to correctly express their chief complaints and cooperate with this study; ⑧ any severe or uncontrolled medical condition that, in the investigator's opinion, may increase the risks associated with study participation or study drug administration, impair the subject's ability to receive the protocol-specified treatment, or interfere with the interpretation of study results.
short-term intervention and health trajectories after mass trauma

Conditions: Post Traumatic Stress Disorder

Summary: this study has two aims. the first is to understand more of what may be typical health trajectories after mass trauma for children and adults and what predicts these trajectories. the second is to understand what may be effective early interventions to prevent long-term health and psychosocial problems for youth (6-19). participants are recruited from an outreach program implemented after a landslide killed 11 persons and destroyed 33 houses in gjerdrum in norway. one third of the inhabitants were evacuated. all evacuated are contacted and screened for trauma related difficulties. those who have significant post-trauma reactions are offered trauma focused interventions.

two short step-wise interventions are developed for this study as an early intervention after mass trauma based on components from tf-cbt to test the relative importance of dosage and the sequencing of components.

Eligibility criteria:
inclusion criteria: * exposed to the landslide * between 6-19 years old * a score of 15 or more on the cats * a score between 11 - 14 on the cats and have additional problems that have started or worsened after the landslide. exclusion criteria: * suicidal * psychotic
experience of rehabilitation amongst individuals with paraplegia

Conditions: Spinal Cord Injuries

Summary: this study is a qualitative study exploring the facilitators to physical and vocational rehabilitation and also explores the barriers in empowering individuals with paraplegia

spinal cord injury is one of the most distressing medical conditions being encountered by today's health care system. in india incidence of spinal cord injury accounts for 20 per million per years population with 20,000 cases added every year. rehabilitation services are of utmost importance in empowering these individuals. so there is a need for more qualitative studies through which needs in rehabilitation services can be upgraded. the aim of the study is to explore the experience of physical and vocational rehabilitation amongst the individuals with paraplegia in india

Eligibility criteria:
inclusion criteria: * traumatic \& non-traumatic paraplegics both male \& female above 18 yrs of age time since injury of minimum 6 months community dwelling paraplegics exclusion criteria: * communication problems psychiatric problems or co morbidities like head injury

Keywords: qualitative research paraplegia rehabilitation
to compare fibrin glue and suture in primary pterygium excision with amniotic membrane transplantation

Conditions: Pterygium

Summary: the purpose of this study is to compared between conventional pterygium excision and amt transplantation with suture and with fibrin glue.

there are few studies about use of fibrin glue in pterygium surgery with conjunctival auto-graft with promising outcome. less recurrent rate, less discomfort and halve surgical time were reported. up to our knowledge,there is no report of fibrin glue in pterygium excision with amniotic membrane transplantation(amt). there is conventional technique to use amt in king chulalongkorn memorial hospital because some benefits over conjunctival auto-graft e.g. * preserve healthy superior conjunctiva for future glaucoma filtering surgery * can use in big or 2-headed pterygium * not contract as conjunctival graft esp. in case of fibrin glue * potential easier to use with fibrin glue * available from thai red cross eye bank comparison(s): amniotic membrane transplantation using fibrin glue compare to suture after pterygium excision.

Eligibility criteria:
inclusion criteria: * primary pterygium exclusion criteria: * pregnant women * recurrent pterygium * pseudopterygium * uncontrolled systemic disease. * known allergy to any of the study agents or preservatives used in the formulations.

Keywords: pterygium pterygia excision amniotic membrane transplantation fibrin glue suture
covid 19-caregivers igg seroconversion

Conditions: Infection, COVID-19

Summary: according to recent publications, the percentage of caregivers infected with covid 19 is evaluated between 10 and 30% . this great variability is due, on the one hand to the intensity of the influx of covid plus patients and, on the other hand, to the disparity in the preparation of caregivers in the face of this emergency. indeed, we can understand that the strict application of hygiene rules can be faulted in the face of the volume of patients, the lack of protective equipment and the lack of specific training for caregivers in this area. as a result, within healthcare teams, there are many questions that generate anxiety: will i be able to provide care properly while protecting myself from the risk of contamination? this anxiety is also present and sometimes manifests itself aggressively in the entourage or in the vicinity of caregivers, due to lack of scientific data adapted to the local ecology of the crisis. thus, the aim of this study is to show that the risk for caregivers of being contaminated by covid in an area dedicated to covid positive patients is no higher than being a caregiver in a non-covid area that he either in the adult or pediatric sector.


Eligibility criteria:
inclusion criteria: * caregivers staff assigned to a non-intensive care covid service * or caregivers staff assigned to a non-covid adult service * or caregivers staff assigned to a non-covid pediatric service * age \> = 18 years old * with health insurance * express consent exclusion criteria: * protected persons * refusal to participate
tka operating room efficiency for tka using customized implant techniques

Conditions: Osteoarthritis, Knee

Summary: this is a multi-centered prospective, consecutively enrolled study that will be conducted in the united states. surgeons that are new users of the itotal knee system (defined by no experience using the customized total knee replacement (tkr) in the last 6 months) will be involved in the study. to complete the study protocol, the center will collect baseline surgical and training data on 10 "off-the-shelf" tkr patients using the implant system the surgeon currently uses. then the first 50 consecutive patients who have been identified to receive the itotal implant (cruciate-retaining or posterior-stabilizing) based on patient factors and the implant system ifu will be enrolled in the study. simultaneous bilateral total knee arthroplasty cases will be excluded.


Eligibility criteria:
inclusion criteria: * \> 18 years of age exclusion criteria: * participation in another clinical study which would confound results * inability to complete the protocol in the opinion of the clinical staff due to safety or other reasons * simultaneous bilateral total knee arthroplasty cases
transcutaneous posterior tibial nerve stimulation for premature ejaculation

Conditions: Premature Ejaculation

Summary: objective: evaluate the effectiveness and safety of transcutaneous electrostimulation of the posterior tibial nerve alone and combined with standard pharmacological treatment, in men with primary premature ejaculation, compared to standard pharmacological treatment. patients and methods: randomized controlled clinical trial. patients diagnosed with premature ejaculation attending boston medical group clinics in colombia and spain will be included. participants will be assigned by randomization to one of three treatment groups: * group 1: tens + placebo drug therapy * group 2: standard treatment (paroxetine 20 mg) + placebo therapy * group 3: tens therapy + standard treatment (paroxetine mg) the change in intravaginal latency time measured with the couple's sustained stopwatch, the change in the pedt scale, the perception of the change in their initial condition after treatment (global clinical impression of change scale), and the change in different domains of the ep (pep scale - profile ejaculation premature) at the end of treatment (week 12) and at three months of follow-up (week 24).


Eligibility criteria:
inclusion criteria: * primary premature ejaculation as defined by the international society for sexual medicine (issm-international society for sexual medicine) (30): a) ejaculation occurs always or almost always within the first minute after penetration, b) disability to delay ejaculation in all or almost all penetrations, c) negative personal consequences are generated, such as stress, discomfort, frustration and / or avoidance of sexual intimacy. * age equal to or greater than 18 years. * pedt score greater than 11. * stable heterosexual relationship of at least 6 months with the interest of maintaining it for at least the duration of the study. * sexual activity at least once a week. * minimum chronicity of pe of 6 months. * voluntary participation in the study. * signature of informed consent prior to participation in the study. exclusion criteria: * iief-ef score greater than 25. * clinically significant comorbidity: cardiovascular, hepatic, thromboembolic, neurological, locomotive, endocrine, oncological, renal or rheumatologic. * history of retroperitoneal surgery, radiotherapy or multiple sclerosis. * history of mental illness: depression, anxiety, suicidal behavior, bipolar disorder, agoraphobia, dysthymia, social phobia, obsessive compulsive disorder, post-traumatic stress, psychiatric disorder, referred by the patient or by the use of a medication for one of these terms. * consumption of medications that affect ejaculatory control such as psychiatric medications, opioid analgesics, alpha blockers. * treatment for pd in the last 3 months. * treatment for epileptic syndromes or parkinson's disease. * use of pacemaker or cardiac defibrillator. * skin lesions in the electrode placement area. * abuse or dependence on piscoactive substances: alcohol, hallucinogenic drugs. * couple in a state of pregnancy.
healthy minds comparison study

Conditions: Depression; Anxiety; Depression/Anxiety

Summary: the goal of this clinical trial is to understand the difference between two versions of the healthy minds application, a digital well-being program. the main question it aims to answer is the differences between versions of the healthy minds application and their effects on well-being. participants will complete an online four-week well-being program and complete surveys sent to their email. participants can expect to participate in the study for four months.


Eligibility criteria:
inclusion criteria: * age ≥18 years * elevated symptoms of depression and anxiety * proficient in english * access to a smartphone exclusion criteria: * prior experience with meditation generally * prior use of the healthy minds application * history of psychosis or mania * alcohol and/or substance use disorder

Keywords: meditation mindfulness
comparison of pediatric septic shock treatment with and without central venous oxygen saturation monitoring

Conditions: Severe Sepsis; Septic Shock

Summary: the purpose of this study was to compare accm/pals guidelines performed with and without central venous oxygen saturation monitoring on the morbidity and mortality rate of children with severe sepsis and septic shock.

background: accm/pals guidelines addresses early correction of pediatric septic shock using physical examination supplemented by indirect measures of cardiac output such as central venous or superior vena cava oxygen saturation (scvo2\>70%) in a goal directed approach. however, these endpoints are based on unsupported evidence. the purpose of this study was to compare accm/pals guidelines performed with and without scvo2 on the morbidity and mortality rate of children with severe sepsis and septic shock. methods: children and adolescents with severe sepsis or fluid-refractory septic shock were recruited at two university-affiliated hospitals and randomly assigned to accm/pals without, or with an scvo2 goal directed (goal scvo2 \> 70%) resuscitation. twenty-eight day mortality is the primary end point.

Eligibility criteria:
inclusion criteria: * patients with severe sepsis or fluid-refractory septic shock that had not responded after 40 ml/kg of any resuscitation fluid or that required cardiovascular agents at any time during resuscitation exclusion criteria: * refusal to sign the written informed consent * age less than 1 month or older than 19 years * uncorrected cyanotic heart disease * patients receiving exclusive palliative care * patients that arrived from other hospitals more than 6 hours after the diagnosis of severe sepsis or septic shock.

Keywords: child septic shock resuscitation central venous oxygen saturation cardiac output goal-directed therapy
the frequency forward head posture in subjects with temporomandibular disorder

Conditions: Temporomandibular Disorder

Summary: the aim of this study was to verify the frequency of the forward head posture in subjects with temporomandibular disorder and to compare them with control group

postural habit is defined as "the attitude of the body" being characterized as good when the parts of the body muscles and bones are lined up and work together in a harmonious form protecting the body of injury or gradual deformity and independently the attitude. the bad posture is a bad habit, but it can be which results in the disagreement of some parts of the body. these are at risk of injury or pain due to and increased tension that the disagreement imposes to the support structures. several study confirm this occurrence relating that this the attitude can alter itself principally if a discomfort occurs. when it occurs there will be the installation of alterations, limitation of movements or even deformity, leading it to the development of an abnormal of posture of the body which will be able to reduce the functional capacity of various structures and organs of the human body. the forward head posture is a common abnormality in cervical spine that can contribute to perpetuation the trigger points in muscles of the head as well as some kinds of temporomandibular disorder. it was suggested its influence in the treatment of patients with orofacial pain and tmd the fhp may occur a result of an acute trauma or if develop itself gradually because of an inadequate position.

Eligibility criteria:
inclusion criteria: study group the criteria of inclusion of the individuals for this group were: * individuals whose main complaint were pain in the muscles of the chew or the tmj * to present pain of the muscle or to articulate during the functional tests * maximum opening interincisal equal or minor than 40 mm crontrol group the criteria of inclusion of the individuals for this group were: * individuals who underwent routine dental treatment * individuals without tmd complaint * maximum opening interincisal bigger than 40 mm exclusion criteria: * there are not

Keywords: temporomandibular disorder orofacial pain posture of the head
action observation training with 3d virtual reality in patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: multiple sclerosis is a chronic, autoimmune and inflammatory disease of the central nervous system characterized by neuronal demyelination and axonal degeneration. upper extremity problems are present in ms patients from an early stage, affecting the performance of the individual and leading to a decrease in activity of daily living ability in proportion to the extent of the problem. action observation training is currently being examined as one of the methods used for the improvement of motor disorders and has been shown in the literature to be effective on different functions in neurological diseases. the aim of this study was to investigate the effects of action observation training with 3d virtual reality on upper extremity functions, fatigue, cognitive functions, activities of daily living and quality of life in ms patients. hypothesis 1: action observation training with 3d virtual reality has an effect on upper extremity functions in ms patients. hypothesis 2: action observation training with 3d virtual reality has an effect on cognitive function in ms patients. hypothesis 3: action observation training with 3d virtual reality has an effect on fatigue in ms patients. hypothesis 4: action observation training with 3d virtual reality has an effect on activities of daily living in ms patients. hypothesis 5: action observation training with 3d virtual reality has an effect on quality of life in ms patients.

the training will involve watching 3d videos of upper limb functions in vr and then repeating the functions by the participants. the aot group will watch video sequences involving upper limb functions, while the control group will watch landscape videos that are not likely to elicit activity in motor or ans areas. in our study, 3d videos of upper limb functions will be recorded with a 360° camera and will be shown to individuals through the vr system from the primary person's perspective.

Eligibility criteria:
inclusion criteria: * \< 2 years ms diagnosis according to mcdonald criteria * between 3.5 and 6 the edss * nine hole peg test \> 30s for at least one upper extremity * no change in medication in the last 6 months * having ms disease with ongoing attacks * \>2 modified ashworth scale in the upper extremities * moca\>25 exclusion criteria: * diagnosed with neurological (except ms), cardiopulmonary, metabolic or musculoskeletal disease that would prevent treatment and evaluation * receiving botulinum toxin treatment in the last 6 months * visual impairment uncorrected by optical devices * inability to adapt to treatment based on 3d immersive virtual reality (e.g. with cognitive impairment, communication problems, psychological problems or vestibular system problems)

Keywords: multiple sclerosis motor learning action observation training virtual reality upper extremity function
study of urethral mobility in male stress urinary incontinence pre- and post- placement of transobturator sling

Conditions: Male Stress Urinary Incontinence

Summary: the hypothesis is men with stress urinary incontinence, including those following radical retropubic prostatectomy and other prostate surgery, have preoperative urethral mobility as measured by magnetic resonance imaging (mri) that improves significantly following sling placement. the investigators theorize that the sling helps with primary hypermobility of this pathophysiologic cause of stress urinary incontinence.


Eligibility criteria:
inclusion criteria: * the control group: * normal male subjects * the intervention group: * male * with stress urinary incontinence * 45 years or older * history of prior radical prostatectomy * complains of stress urinary incontinence * scheduled for a transobturator sling surgery * ability and willingness to provide written consent exclusion criteria: * absolute or relative contraindications to mri * claustrophobia * inability to undergo the male sling surgery * pi judgement absolute contraindications to mri: * electronically, magnetically, and mechanically activated implants * ferromagnetic or electronically operated active devices * metallic splinters in the eye * ferromagnetic hemostatic clips in the central nervous system relative contraindications to mri: * cochlear implants * other pacemakers * nerve stimulators * lead wires or similar wires * prosthetic heart valves * hemostatic clips * non-ferromagnetic stapedial implants

Keywords: sui stress urinary incontinence male transobturator sling
long term treatment of end stage renal disease patients with lanthanum carbonate (fosrenol)

Conditions: Hyperphosphatemia

Summary: patients who have been treated with fosrenol for a minimum of 12 consecutive weeks and are receiving dialysis will be followed for 5 years to compare mortality, bone fractures and incidence of selected morbidities to patients with no lanthanum exposure and to patients being treated for hyperphosphatemia with any marketed product.


Eligibility criteria:
inclusion criteria: test group * signed informed consent * patient must have esrd and be receiving dialysis * prior treatment with fosrenol for a minimum of 12 consecutive weeks * primary payer of healthcare must be medicare (patient must supply medicare claim number) * patient must be 18 years of age or older exclusion criteria: test group * patients that do not meet inclusion criteria