Kornimate/medical-research-clean huggingface dataset:
tip repair of distal penile hypospadias using rapidly absorbable braided vs slowly absorbable monofilament sutures

Conditions: Hypospadias Repair

Summary: objective: to study the effect of tubularizing the urethral plate in dph in children using 2 different absorbable suture materials, rapidly absorbable, braided 6/0 vicryl and slowly absorbable monofilament 6/0 polydioxanone, on complication rates. patients and methods: a prospective, randomized controlled study conducted at the urology department, cairo university specialized pediatric hospital, abou el reesh, between september 2021 and september 2022. a total of 69 boys aged between 8 and 120 months with dph were randomly divided into 2 groups: group(a) vicryl included 39 boys and group(b) pds included 30 boys. all boys were uncircumcised with no chordee and were primary repairs. tip was the surgical technique used by a single pediatric urologist. follow up was performed in outpatient clinic at 7 days, 1, 3, 6 and 12 months postoperatively. the complications and reoperation rates for both groups were compared.


Eligibility criteria:
inclusion criteria: * any child(aged from 6m to 12 years old) with distal penile hypospadias (dph) ( uncircumcised, without chordae, with good penile size and urethral plate(candidates for t.i.p repair) exclusion criteria: * reccurent cases, * circumcised cases * other types of hypospadias rather than dph, * presence of chordae, * poor urethral plate
to access the effects of mucositis in adults with dental implants

Conditions: Mucositis

Summary: clinical research for the treatment of mucositis subjects who have dental implants for a minimum of one-year.


Eligibility criteria:
inclusion criteria: * male and female subjects, ages 30-70. * availability for the six-month duration of the clinical research study. * good general health. * subjects who have lost teeth for periodontal disease reasons and who have been restored with implants. * minimum of 5 remaining teeth and a minimum of 2 implants. * initial evaluation of the gingival and peri-implant mucosal tissues by determining full mouth bleeding on probing. * initial plaque evaluation by determining full mouth presence/absence of plaque. * signed informed consent form. exclusion criteria: * tumor(s) of the soft or hard tissues of the oral cavity. * untreated periodontal disease (purulent exudate, tooth mobility, and/or extensive loss or periodontal attachment or alveolar bone). * carious lesions requiring immediate restorative treatment. * uncontrolled diabetes * use of antibiotics any time during the one month prior to entry into the study. * untreated peri-implantitis. * participation in any other clinical research study or test panel within the three months prior to entry into the study. * pregnant women or women who are breast feeding. * history of allergies to personal care/consumer products or their ingredients. * medical condition which prohibits not eating/drinking for up to 2 hours. * current alcohol or drug abuse. * systemic or local disease conditions that would compromise post-operative healing. * regular use of anti-inflammatory drugs.
an evaluation of azr-md-001 as treatment for meibomian gland dysfunction (mgd) or contact lens discomfort (cld)

Conditions: Meibomian Gland Dysfunction (MGD); Contact Lens Discomfort (CLD)

Summary: sovs2019-070 is a single-center study of azr-md-001 ointment and azr-md-001 vehicle in patients with meibomian gland dysfunction (mgd) or contact lens discomfort (cld).

sovs2019-070 is a single-center, single-masked (the individual(s) performing efficacy measures will be masked to treatment assignment for the patient(s) they are assessing), vehicle-controlled, randomized, parallel group study of azr-md-001 ointment and azr-md-001 vehicle in patients with meibomian gland dysfunction (mgd) or contact lens discomfort (cld).

Eligibility criteria:
inclusion criteria: * mgd patients: * evidence of meibomian gland obstruction (based on a meibomian gland secretion (mgs) score of ≤12 for 15 glands of the lower lid) in both eyes at the baseline visit * reported dry eye signs and symptoms within the past 3 months * tbut \< 10 seconds in both eyes * cld patients: * evidence of meibomian gland obstruction (based on a meibomian gland secretion (mgs) score of ≤12 for 15 glands of the lower lid) in both eyes at the baseline visit * a history of wearing soft contact lenses for at least 6 months * wearing of the soft contact lenses for at least 3 weeks before the baseline visit and wore or attempted to wear lenses at least 4 times a week before the baseline visit. * symptomatic as defined by an answer of "no" at baseline to the question, "are you able to comfortably wear your lenses as long as you want?" * self-reported history of contact lens dryness/intolerance in the 6 months preceding the baseline visit. * baseline cldeq-8 score \>12 * contact lens may be use during the study as long as they are removed 15 minutes before dosing and not reinserted until at least 15 minutes after dosing. exclusion criteria: * uncontrolled ocular disease (except for mgd or cld) or uncontrolled systemic disease * patient has glaucoma or ocular hypertension * corneal abnormality or disorder that impacts normal spreading of the tear film or corneal integrity * bcva worse than 20/40 in either eye at the baseline visit
sleep, fatigue, and dexamethosone in children with leukemia

Conditions: Leukemia

Summary: the purpose of this study is to determine the relationship between dexamethosone (steroid) and children's sleep and fatigue.

approximately 134 children and adolescents will be enrolled. all children and adolescents will wear a wrist actigraph for two consecutive 5-day study periods. children and adolescents will have blood drawn 2 times on day 1 when they are on dexamethosone. their parents will complete a sleep diary and fatigue questionnaire by telephone on days 2 and 5 of both study periods.

Eligibility criteria:
children and adolescents with leukemia, both genders

Keywords: drug adverse effect pediatric cancer
microvascular reactivity.

Conditions: Diabetes; Retinopathy; Vascular Pathology

Summary: this study attempts to test capillary responses to various challenges without the need for iontophoresis (electrical current).

studies of microvascular responsiveness often employ iontophoresis to fascilitate drug absorption. iontophoresis is a confounding stimulus in such studies, and we are attempting to create tests of the microvasculature that do not require iontophoretic drug delivery.

Eligibility criteria:
inclusion criteria: diabetic. - exclusion criteria: not on nitrates or mydriatic eye drops within 48 hours. -

Keywords: endothelium iontophoresis acetylcholine nitroglycerin vasodilation
home exercises protocol for neck pain

Conditions: Neck Pain

Summary: delphi study about home exercise protocol development for neck pain.

introduction: neck pain is rising globally as a musculoskeletal disorder, as a result of several factors. currently, there are several types of treatments for cervicalgia, applied according to the therapist's choice and patient's conditions and preferences, however, there are no reports of an effective self-performing treatment aiming to stabilizing the cervical, giving musculoskeletal balance, and focus on reducing pain. it is important the promotion of a self-performing treatment, resulting in a high cost benefit because patient does not have to move to perform the treatment outside his or her home, does not need financial resources and demands little time to perform it. in addition to decreasing the frequency and intensity of hospitalizations and government costs incurred in this musculoskeletal disorder. therefore, the study aims to construct, validate and adapt a self-performing exercise protocol in reducing cervical pain. methods: the first phase was the development of the first version of the protocol, through literature search; in the second phase, the content was validated, through evaluation by a committee of nine physiotherapists judges using the delphi technique; and the last phase of the protocol, the cultural adequacy, is being performed through evaluation by fifteen participants of the target population to assemble the final version of the protocol.

Eligibility criteria:
inclusion criteria: * judges: physical therapists with at least 2 years of experience in cervical area. * target population: chronic neck pain. exclusion criteria: * vestibular system problems, balance impairment, nervous system-related disorders, inability to perform exercises, history of cervical trauma or surgery in the region, history of cervical radiculopathy, history of cervical spine injury, temporomandibular dysfunction.

Keywords: stabilization exercise delphi
agreement among expert radiologists in diagnosing primary liver tumors by magnetic resonance imaging (mri)

Conditions: Neoplasms

Summary: the purpose of this multicenter study is to evaluate the agreement among expert radiologists in interpreting magnetic resonance images (mri) assessing common primary liver tumours in non-cirrhotic patients.

magnetic resonance imaging (mri) is currently the method of choice for non-invasive diagnosis of primary liver tumors. however, differentiation of hepatocellular carcinoma (hcc) from adenoma and focal nodular hyperplasia (fnh) remains challenging, particularly in non-cirrhotic patients.

Eligibility criteria:
inclusion criteria: * histopathological diagnosis of hepatocellular cancer (hcc), adenoma and/or focular nodular hyperplasia (fnh). * patients that received a pre-operative magnetic resonance imaging (mri). * patients that underwent liver resection with an intention to cure. * patient over 18 years of age exclusion criteria: * other histopathological diagnosis such as cysts and hemangiomas. * patient age less than 18 years of age.

Keywords: liver neoplasms magnetic resonance imaging surgery pathology
ultrasound in detecting lymph node metastasis in older patients undergoing breast sonography

Conditions: Breast Cancer

Summary: this pilot clinical trial studies ultrasound in detecting lymph node metastasis in older patients with undergoing breast sonography. diagnostic procedures, such as ultrasound, may help find breast cancer and find out how far the disease has spread

primary objectives: i. to develop a reliable and consistent set of guidelines for utilizing diagnostic ultrasound to assess axillary lymph nodes for patient suspicious of breast cancer with possible nodal metastasis. secondary objectives: i. to explore whether the data collected can be used for pathologic validation of metastatic disease. outline: patients undergo breast ultrasound.

Eligibility criteria:
inclusion criteria: * patients referred for a breast ultrasound * patients who have had a mammogram with a breast imaging reporting and data system (birads) of \>= 4 * patients who are undiagnosed for breast cancer exclusion criteria: * patients who have had breast cancer surgery
intervention to motivate teens to be a designated organ donor on driver's license

Conditions: Tissue and Organ Procurement; Alcohol Abstinence

Summary: this study will test the effectiveness of a multimedia campaign to educate ethnic minority teens about the choice to become a designated organ donor on their first driver's license.

less than a fourth of ethnic minority teens in the u.s. are a designated donor (dd) on their state-issued driver's license. asian-american/pacific islander (aa/pi) adolescents in hawaii are even less likely to be a dd or to have talked to their family about becoming an organ donor. health education interventions for adolescents have demonstrated improvements in knowledge and intentions to be an organ donor; but, aa/pi teens are underrepresented in such studies. nevertheless, whether changes in knowledge or intentions result in more organ donors is unclear, since previous studies have not included a concrete behavioral outcome such as the teen becoming a donor on their driver's license. this application will test, via a randomized clinical trial, the efficacy of an interactive multimedia intervention (imi) to increase the number of aa/pi adolescents who are a dd on their state issued driver's license, identification card, or organ donor card/donor registry. teen groups will be recruited from the community (churches and high schools, n = 40 groups, 530 teens) and randomly assigned to either the intervention or a comparison condition on prevention of underage drinking of alcohol. the theoretically-derived intervention will include culturally sensitive messages and information about being a designated donor that will be delivered via a dvd, email, text/instant messaging, and websites. the comparison condition includes materials (dvd) previously shown to increase awareness about laws restricting access to alcohol by teens. the primary outcome is objectively validated donor status on a teens' driver's license/state identification card (id) or donor card after 12 months of intervention. a secondary outcome is the reported rate of family discussions about organ donation and knowledge/intentions about donation. we hypothesize the youth groups assigned to the intervention will have higher rates for family discussions and dd status, compared to groups in the comparison condition. we will also test whether psychosocial and cultural factors act as mediators of any change in teens' knowledge, attitudes \& stages of change to become a dd. after the randomized trial we will disseminate the intervention to organ procurement organizations in hawaii and other states, and track diffusion outcomes over a year. if imi methods can increase the number of minority teens who become a dd on their driver's license by 10% this would translate to 500,000 more teenage designated donors in the u.s.

Eligibility criteria:
inclusion criteria: * adolescent aged 14-19 * member of a school club, youth program or teen group * read and speak english * parent provides consent exclusion criteria: * plans to permanently move out of state

Keywords: ethnic minority adolescents designated organ donor
clinical study of vitamin b5 in adjuvant treatment of ibd

Conditions: Inflammatory Bowel Diseases

Summary: patients with ibd are randomized to oral administration of vitamin b5 and placebo based on the standard treatment, exploring whether vitamin b5 can increase the clinical remission rate of ibd patients and improve the treatment effect.


Eligibility criteria:
inclusion criteria: * patients diagnosed with ibd according to the consensus on the diagnosis and treatment of inflammatory bowel disease (beijing, 2018, doi:10.19538/j.nk2018090106); * have complete medical history data; * volunteer to participate in this clinical trial and sign the informed consent form. exclusion criteria: * hemophilic patients; * there are abdominal abscesses, toxic megacolon, fulminant colitis, partial colectomy, or total colectomy; * other autoimmune diseases, hematological diseases, tumors, acute infection, severe liver and kidney insufficiency, serious diseases such as severe anemia, neutropenia, heart failure, organic heart disease, hepatitis b, liver cirrhosis, kidney disease and mental diseases; * take calcium pantothenate preparation in recent 3 months; * have a history of abuse of psychoactive substances; * pregnant or lactating women, or plan to be pregnant in the next 6 months; * nervous system diseases: such as alzheimer's disease, stroke, parkinson's disease; * participate in other clinical trials in the past 6 months; * incomplete medical record information (including gender, age, diagnosis information, colonoscopy results, pathological diagnosis results and other demographic data)

Keywords: vitamin b5,treatment
effect of salmeterol on brain-derived neurotrophic factor (bdnf) concentrations in asthma

Conditions: Allergic Asthma

Summary: bdnf has been linked to the pathogenesis of airway hyperresponsiveness in asthma. in this trial, the impact of a treatment with salmeterol and salmeterol / fluticasone on bdnf concentrations will be assessed in patients with asthma. the investigators hypothesize that salmeterol impacts on bdnf concentrations in patients with asthma.


Eligibility criteria:
inclusion criteria: * age \> 18 years, a physician's diagnosis of allergic asthma * a documented sensitization to aero-allergens (pollen, animal hair, or house dust mite) * a pre-bronchodilator forced expiratory volume in the first second (fev1) \> 80 % of the predicted value (% predicted), a provocative concentration of histamine causing a 20 % fall in fev1 (pc20) of \< 8 mg histamine / ml exclusion criteria: * no regular treatment (only short-acting inhalers on demand were allowed) * no history of or evidence for any other chronic disease than asthma * no history of smoking, absence of any signs or symptoms of an infection

Keywords: airway hyperresponsiveness
electrical cardioversion as a predictor in postoperative preservation of sinus rhythm

Conditions: Atrial Fibrillation; Atrial Fibrillation, Persistent

Summary: the aim of this study is to evaluate benefits of electric cardioversion in the early and long-term postoperative period in patients after radiofrequency catheter isolation of pulmonary veins. parameters of the left atrium will be evaluated by transthoracic echocardiography and electroanatomic mapping. preservation of the sinus rhythm will be assessed by 24-hour electrocardiographic monitoring. the main question that is planned to be answered is: does a reverse remodeling of the left atrium and/or a decrease in the progression of the fibrosis zone occur after performing electrical cardioversion (and before subsequent catheter ablation) in patients with persistent and long-standing persistent atrial fibrillation (af)? can performed electrical cardioversion serve as a predictor of af freedom in this group of patients? participants will undergo a follow-up examinations (echocardiography, ecg, 24-hour ecg monitoring) at the 3rd, 6th and 12th months after catheter ablation. based on the results of these examinations, the recurrence rate of af will be estimated. two groups of patients will include both persistent and long-standing persistent af. experimental group will include patients who underwent electrical cardioversion before the intervention, and active comparator group will include those patients who did not undergo it. the experimental group will be subdivided into a persistent af patients who were successfully cardioverted in sinus rhythm and persistent af patients who failed to restore sinus rhythm during dc at the time of catheter ablation. analysis and comparison of subgroups will be performed.


Eligibility criteria:
inclusion criteria: * informed consent signed by the patient to participate in the study. * persistent atrial fibrillation resistant to antiarrhythmic drugs for 6 months or more * the size of the left atrium is less than 55 mm, volume is less than 130 ml, volume index (lp) is less than 55 ml/m2 exclusion criteria: * reversible causes of atrial fibrillation (hyperthyroidism, pericarditis, myocarditis). * patients in need of myocardial revascularization and/or heart valvular disease correction. * any previous intervention (including maze surgery, thoracoscopic ablation; implanted occluder of the auricle of the left atrium.). * patients with severe concomitant pathology requiring correction. * contraindications for administration of anticoagulant therapy. * documented presence of a blood clot in the cavity of the left atrium or other reasons preventing the insertion of catheters into the left atrium. * bmi of 40 or more

Keywords: atrial fibrillation cardioversion catheter ablation late recurrence left atrial voltage left atrial volume
zalutumumab in combination with chemotherapy and radiotherapy in head and neck cancer

Conditions: Head and Neck Cancer; Squamous Cell Cancer

Summary: the purpose of this study is to investigate the safety of zalutumumab in combination with chemotherapy and radiotherapy as treatment of patients with head and neck cancer


Eligibility criteria:
inclusion criteria: * patients with locoregionally advanced squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx or larynx exclusion criteria: * prior treatment with radiotherapy in the head and neck area * prior treatment with chemotherapy * prior treatment with similar drugs (e.g. egfr antibodies, egfr inhibitors) * previous surgery with curative intent for head and neck cancer
oral sodium blood pressure in normal weight, overweight and obese volunteers

Conditions: Obesity

Summary: the primary objective of this study is to analyze the sensitivity of blood pressure to oral salt intake. matched male and female participants will be selected as normal weight, overweight, and obese. participating subjects will have a first visit with blood pressure measurement and a blood sample. in two consecutive phases of one week, subjects will receive 12 pills of sodium (6 grams) or corresponding placebo. blood pressure will be measured at the end of each phase.


Eligibility criteria:
inclusion criteria: * informed consent * age 18-45 for adults and 6-8 for children exclusion criteria: * african ethnicity (known to affect blood pressure sensitivity to salt) * chronic condition affecting blood pressure * diabetes (known to affect blood pressure sensitivity to salt) * hypertension

Keywords: blood pressure
effects of biphasic insulin aspart 70/30 vs. exenatide in type 2 diabetes patients not reaching blood glucose targets on metformin and a sulfonylurea.

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in the united states of america (usa). the study will compare a1c reduction achieved in patients receiving biphasic insulin aspart 70/30 once or twice daily to patients receiving exenatide twice daily. patients enrolled in the study will be insulin naive patients who have not achieved glycemic control with metformin and sulfonylurea.


Eligibility criteria:
inclusion criteria: * type 2 diabetes * hba1c: at least 8% * patients that were never treated with insulin before * current therapy with metformin and a sulfonylurea. exclusion criteria: * history of recurrent, severe hypoglycemia * hepatic insufficiency: alt, ast or alkaline phosphatase \> 2.5 times upper limits of laboratory's normal * renal insufficiency: serum creatinine \> 1.3 mg/dl (males) or \> 1.2 mg/dl (females) * severe gastrointestinal disease, including gastroparesis