Kornimate/medical-research-clean huggingface dataset:
amniotic fluid mesenchymal stem cells developed for chondrogenic treatment (afcc) injection in elderly knee osteoarthritis patients

Conditions: Knee Osteoarthritis

Summary: amniotic fluid mesenchymal stem cells developed for chondrogenic treatment (afcc) are used to treat elderly patients suffering from knee osteoarthritis (oa). the injection reduces inflammation and promotes the recovery of knee function, leading to an improved quality of life.

ten patients, aged between 60 and 80 of both genders, who were diagnosed with knee osteoarthritis at kellgren and lawrence (kl) score 2-3 were selected based on strict inclusion and exclusion criteria. each patient was treated with a single intra-articular injection of 20 million cells of amniotic fluid mesenchymal stem cells in afcc type into an oa knee. after the treatment, they were monitored through clinical assessment and laboratory investigation, including blood chemistry test and magnetic resonance imaging (mri) of the treated knee.

Eligibility criteria:
inclusion criteria: 1. age between 60 to 80 years 2. the visual analog scale (vas) score of the subject's knee joint was greater than 4 3. knee pain needs at least 15 days of experience. 4. the kellgren lawrence grade of the subject's knee joint was ii/iii as per the axial position x-ray. 5. subjects who understand and voluntarily sign the consent. exclusion criteria: 1. the subject has secondary osteoarthritis (such as other joint arthritis, major trauma on the study joint in the previous 3 months, axial deviation angle beyond 15 degrees of the bones of the knee joint) 2. the subject has other known rheumatic or inflammatory diseases (such as rheumatoid arthritis and inflammatory arthritis). 3. the subject has other conditions that cause knee joint pain (such as cancer, joint tumor) 4. the subject who awaiting knee surgery 5. the subject has an underlying disease that affects treatment during 1 year (such as cancer, liver disease, severe kidney disease, sle) 6. the subject has a history of vertebral fracture or leg bone fracture 7. the subject has a nervous system disorder that affects balance (such as stroke or parkinson's disease) 8. the subject has an acute or chronic infectious disease 9. the subject who had evidence of knee surgery 10. the subject who has received intra-articular steroids or other substances within the last 6 months. 11. the subject who has received symptomatic slow-acting drugs for osteoarthritis (sysadoa) within the last 4 months 12. the subject has a deformity of the knee joint. 13. the subject has any other pathological conditions 14. the subject has a communication problem 15. the subject has claustrophobia 16. the subject who had surgery to insert a cardiac pacemaker 17. the subject who had surgery to insert an aneurysm clip 18. the subject who had surgery to insert a cochlear implant 19. the subject has any internal metallic objects (such as metal plates, surgical clips, bullets)

Keywords: amniotic fluid mesenchymal stem cells knee osteoarthritis
comparing anugel with gelatine sponges for pain management after hemoroidectomy

Conditions: Pain, Postoperative

Summary: post-operational pain is the most common problem relating to haemorrhoidectomy. this study aims to evaluate the postoperative effects of anugel a hydrogel impregnated multi component sponge vs gelatine sponge comparatively.

the patients were placed in the lithotomy position. haemorrhoids (piles) were later located through exploration. the piles were dissected using ligasure. after completing the dissection, bleeding was controlled and either anugel or the gelatine sponge (spongostantm) is inserted in to the rectum as determined by patient allocation. the patients were monitored post operation and 5 days following the surgery. pain was measured using the vas scale and use of pain medication was monitored.

Eligibility criteria:
inclusion criteria: * haemorrhoid (grade 3-4) exclusion criteria: * repeating cases, additional (non haemorrhoid related) complications

Keywords: hemoroidectomy
contribution lus in the diagnosis of acute heart failure (ahf) in patients admitted to the ed

Conditions: Dyspnea; Cardiac

Summary: this study assesses the potential of lung ultrasonography to diagnose heart failure.

dyspnea is one of the most distressing situations for the patient . emergency cases do not always present in conditions that are ideal for immediate diagnosis, which sometimes compromises outcome. physical examination, laboratory findings and radiography are imperfect, resulting in a need for sophisticated test results that delay management. lung ultrasonography is becoming a standard tool in critical cases in the ed. the investigators aim to perform ultrasonography on consecutive patients admitted to the icu with dyspnea, comparing lung ultrasonography results on initial presentation with the final diagnosis by the icu team. three items were assessed: artifacts (horizontal a lines or vertical b lines indicating interstitial syndrome), lung sliding, and alveolar consolidation and/or pleural effusion, these items were grouped to assess ultrasound profiles. this study assesses the potential of lung ultrasonography to diagnose heart failure.

Eligibility criteria:
inclusion criteria: * non traumatic dyspnea with the final diagnosis of heart failure exclusion criteria: * coma, * shock,mechanical ventilation, * vasopressor drugs * arrhythmia serious and sustained, * non consent

Keywords: lung ultrasound, heart failure diagnosis accuracy
the diagnostic benefits of the hyperqtm system in ecg stress testing

Conditions: Myocardial Ischemia

Summary: the main objective of this study is to determine the usefulness of the hyperq™ system in improving the positive predictive value of conventional ecg stress testing. patients who are referred for stress test will perform an ecg stress test on a treadmill, with high-frequency ecg recording from conventional 12 leads using bsp's hyperq™ system. conventional 12 lead ecg, as well as hyperq™ recordings will be provided by the hyperq™ system. the results of the conventional test and the hyperq™ data will be compared, using one of three cardiac tests (stress echocardiography, spect myocardial perfusion imaging and angiography) as gold standards. statistical analysis will compare the sensitivity, specificity, ppv and npv of the conventional and hyperq™ stress ecg in detecting myocardial ischemia.

the study population will comprise of 1200 patients referred to stress test in three maccabi clinics or cardiac medical centers. all patients will perform an ecg stress test with high-frequency ecg recording from conventional 12 leads using bsp's hyperq™ system. the recording will be done without affecting or interfering with any aspect of the normal due course of the test. standard bruce protocol or modified bruce protocol will be used, with standard test termination indications. two minutes of rest ecg will be recorded prior to stating the protocol. following the test, the physician will interpret the test's results in the conventional manner (e.g. st changes, chest pain, etc) and decide whether the subject should be referred to additional tests. hyperq™ data will be analyzed in two phases: (i) interpretation by the physician in a non-blinded manner one day following the stress test and (ii) after performing all the exercise tests of the study group, blindly to the conventional diagnosis and the hyperq™ analysis done previously, as well as to other outcomes of imaging procedures. the first hyperq™ reading will be used to detect the subjects who were positive according to the hyperq™ system but negative according to the conventional stress testing. these subjects will be referred by the physician to further clinical investigation. the first reading will also be used to assess the physician's interpretation in a scenario that represents a realistic clinical setting, while the second reading will be used to examine the unbiased clinical benefit of hyperq™ data.

Eligibility criteria:
inclusion criteria: * subject referred to stress ecg * subjects age ≥ 45 * subject signed an informed consent form exclusion criteria: * subject with contraindications for stress ecg * subject with implantable pacemaker or defibrillator * subject with lbbb * subject with qrs duration ≥ 110 msec * subject with wolff-parkinson-white syndrome

Keywords: ischemia myocardial hf-ecg
early lactate clearance rate in sepsis

Conditions: Early Lactate Clearance

Summary: to assess the influence of early lactate clearance rate monitoring in patients with sepsis.


Eligibility criteria:
inclusion criteria: * all patients whose blood lactate level reached or exceeded 2.0 meq / l exclusion criteria: * incomplete clinical data

Keywords: sepsis lactate early
frontal amplitude-integrated electroencephalogram in early prognostication after cardiac arrest

Conditions: Heart Arrest

Summary: the investigators examine the prognostic value of continuous electroencephalography on frontal area of brain according to time by performing amplitude-integrated electroencephalography (aeeg) on cardiac arrest patients receiving therapeutic hypothermia.


Eligibility criteria:
inclusion criteria: * age: 19 years and older * underwent th exclusion criteria: * died within 72 h after cardiac arrest * spontaneous or traumatic brain injury * known history of neurological diseases (such as epilepsy)

Keywords: heart arrest hypothermia eeg prognosis
effects of universal exercise unit therapy with task-oriented training in cp children

Conditions: Cerebral Palsy Children

Summary: cerebral palsy is a problem that affects the development and motor skills caused by early non-progressive central nervous system damage. muscle rigidity, spasticity, fragility, uncontrolled movement, or a combination of these abnormalities characterized it. therapeutic usage of the universal exercise unit is common. also called a spider cage or monkey cage. this device helps people with motor problems, especially cerebral palsy. this metal 3-dimensional contraption uses wires, rubber bands, pulleys, weights, and belts. the goal is to engage the vestibular and proprioceptive systems, which are necessary for balance, coordination, and awareness.

a randomized clinical trial (rct) design will be employed, conducted at the sialkot medical and physiotherapy center over 10 months following synopsis approval. the anticipated sample size, accounting for a 20% attrition rate, will be 34 participants in each of the two study groups. group a will undergo universal exercise unit (ueu) therapy along with task oriented training, while group b will receive task-oriented training for gross motor functioning. the sampling technique will be non-probability convenience sampling, with inclusion criteria comprising children aged 5-15 diagnosed with spastic cerebral palsy, of both genders and in stable health condition. the data collection tools include the gross motor function measure 88 (gmfm 88), trunk impairment scale (tis) and pediatric balance scale. the analysis will be conducted using spss for windows software version 25. training sessions, lasting 6 weeks, will be conducted twice a week, and data will be collected before and after each session. the ueu therapy will focus on various movements facilitated by the equipment, while the task-oriented training will be personalized, targeting specific functional limitations through activities simulating daily tasks.

Eligibility criteria:
inclusion criteria: * children who were spastic and able to understand and follow commands. children aged 5-15 years old. gross motor function classification system (gmfcs) level i-iii. youngsters are capable of walking and standing on their own. exclusion criteria: * children with severe physical limitations and disabilities. children with planned surgeries in the next 6 months. any musculoskeletal or orthopedic conditions limiting participation in exercise programs. kids with planned surgical or medical surgeries during the study period. children with impaired cognition. children with hearing impairment and visual impairment.
patient satisfaction after surgery for otosclerosis under local ou general anesthesia

Conditions: Otosclerosis; Otosclerosis Surgery

Summary: main purpose of this study is to compare comfort level of patients, after otosclerosis surgery, under local or general anesthesia.

the care system will not differ from the usually treatment of patients. patients will decided about the type of anesthesia (local or general) after detailed description of both procedures. all operations will be performed by the same surgeon and the same basic surgical technique. the only difference is that patients included in thi study will have to complete a satisfactory survey 10 days after surgery and a gbi questionnaire 3 months after surgery, during the post operative consultations .

Eligibility criteria:
inclusion criteria: * patients older than 18 years suffering from otosclerosis who have surgical indication. * patients who want surgical treatment for their otosclerosis * clinic : deafness with social prejudice and normal otoscopic exam * audiometric : conductive or mixed hearing loss with abolition of the aural reflex. audiometric threshold more than 30decibel (db) and air bone gap more important than 20db. * pré operative scan in favor of otosclerosis * diagnosis confirmation during the surgery with stapes sclerotic's attachments to the oval window exclusion criteria: * history of ear surgery * no medical objection to local anesthesia * no medical objection to general anesthesia * no medical objection to ear surgery * no legal protection for adults * no participation refusal

Keywords: otosclerosis otosclerosis surgery local anesthesia general anesthesia comfort assessment glasgow benefit inventory questionnaire hearing results
nasal humidified high flow oxygen during weaning from mechanical ventilation : ultrasonography study

Conditions: Adult Patients Ventilated More Than 48 h; Stable Respiratory and Hemodynamic Conditions for SBT; Consent of Patients; Arterial Line

Summary: this is a prospective, randomized clinical multicentric study in icu (intensive care university)during weaning from mechanical ventilation.

prospective randomized clinical multicentric study on icu (intensive care university) comparing nasal humidified high flow therapy versus standard oxygen with lung ultrasound score during weaning from mechanical ventilation

Eligibility criteria:
inclusion criteria: * adult patients ventilated more than 48 h * stable respiratory and hemodynamic conditions for sbt * consent of patients * arterial line exclusion criteria: * cobp * laryngeal dyspnea * tracheostomy * arythmya * no echogenicity * paraplegia \>t8

Keywords: weaning from mechanical ventilation lung ultrasound oxygen inhalation therapy
atrial fibrillation (af) patients not taking vitamin-k antagonist (vka)

Conditions: Persistent or Permanent Non-valvular Atrial Fibrillation

Summary: the purpose of this study is to assess the safety and tolerability of azd0837 in patients with atrial fibrillation who are unable or unwilling to take vitamin k antagonist therapy for up to 3 months.


Eligibility criteria:
inclusion criteria: * either one of the following risk factors is sufficient for inclusion (high risk patient) * previous cerebral ischaemic attack (stroke or transient ischaemic attack (tia), \>30 days prior to randomization) * previous systemic embolism or at least one of the following risk factors are needed for inclusion: age ≥75 years * symptomatic congestive heart failure * impaired left ventricular systolic function * diabetes mellitus; hypertension requiring anti-hypertensive treatment * in addition to af the patient must be appropriate for but unable or unwilling to take vka therapy exclusion criteria: * presence of a clinically significant valvular heart disease;; stroke or tia and/or systemic embolism within the previous 30 days prior to randomization * conditions associated with increased risk of major bleeding
hsv 1 and 2 gowey protocol versus placebo

Conditions: Herpes

Summary: this study will compare efficacy of versabase gel with 20% sarracenia purpurea versus placebo applied every 3-4 hours to herpes lesions.

patients screened for hsv one or two. patients with herpes given a 1/8 oz of gel. researcher does not know which is active and which is placebo (placebo is actually just versabase gel). patent applies gel to lesions every 3-4 hours. returns to clinic on days 3, 5, and 14 for evaluation. up to 50 patients may be enrolled.

Eligibility criteria:
inclusion criteria: - hsv 1\&2 exclusion criteria: * no active lesions
using heavy water to study cell dynamics in parkinson's disease

Conditions: Parkinson's Disease; HIV Infections

Summary: this pilot study will assess the feasibility of using heavy water as a safe 'tracer' for biomarker studies of diseases of the brain and spinal cord, that, together, are also called the central nervous system (cns). heavy water, also called deuterated water or d20, is the same as normal drinking water except the hydrogen atoms have been replaced by deuterium, a naturally occurring isotope of hydrogen. in particular, this study will use heavy water to define: 1) the rate of immune cell proliferation (growth) in the cerebrospinal fluid (csf) compared to blood. this study will be examining a particular type of immune cell called t lymphocytes. 2) this study will also examine selected molecules generated by nerve cells of the cns to understand their rate of secretion and turnover in healthy control participants, hiv-1-infected participants and participants with a non-hiv-related neurodegenerative disease such as parkinson's disease (pd). this study will involve the administration of heavy water orally for either seven days, 12 days or six weeks. measurements will be taken by lumbar puncture (lp, also known as a spinal tap). blood (approximately five tablespoons per visit) will also be obtained at each of the lumbar puncture appointments. if this method can be used to establish the rates of immune cell turnover and the production rates of neuronal molecules using cerebrospinal fluid, it will provide unique data that is important to understand chronic neurodegenerative conditions, like pd, and to measure responses to targeted therapies. hypothesis: 1. d2o, administered orally, can be used to measure the proliferation rates of csf t cells (and, eventually, of their major phenotypic subsets). 2. d2o can be used to assess the turnover and production rates of cns constituents that are normally or pathologically shed or secreted into the csf, including (eventually): cargo molecules transported specifically in neurons in the cns, such as chromogranin-a and -b, neuregulin-1 (specifically the extracellular secreted ectodomain of neuronal differentiation factor (ndf) isoform type α1, α2, β1, and the acetylcholine receptor inducing activity isoform (aria), secreted amyloid precursor protein (sapp), alpha-synuclein; and app metabolites amyloid beta (aβ) 41 and 42.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * healthy controls with no significant medical conditions * diagnosed hiv positive patients on or off arvs * diagnosed parkinson's disease patients * capacity to provide informed consent exclusion criteria: * none

Keywords: hiv brain diseases spinal fluid hiv positive
endometrial markers and response of endometriosis patients to prolonged gnrh agonist prior to ivf

Conditions: Endometriosis; Infertility

Summary: this prospective randomized trial evaluates whether one can predict which infertile women with endometriosis who are candidates for in vitro fertilization will benefit from prolonged therapy with a gnrh agonist by the determination of the absence of endometrial expression of the integrin, alpha v, beta 3 vitronectin. this is a prospective randomized trial in which all patients will undergo endometrial biopsy prior to initiation of ovarian stimulation for in vitro fertilization and then undergo randomization to a three month course of a depot preparation of the gnrh agonist leuprolide acetate in depot suspension prior to ovarian stimulation or standard therapy. prio

see summary

Eligibility criteria:
inclusion criteria: * infertility * surgical diagnosis of endometriosis * normal ovarian reserve testing * regular menses exclusion criteria: * irregular menses * undiagnosed abnormal uterine bleeding * pregnancy * prior adverse reaction to any gnrh agonist * ovarian cystic or solid mass \> 3cm in mean diameter at study entry * use of a depot preparation of a gnrh agonist or any hormonal therapy for endometriosis within 6 months of study entry * current hepatic, renal, hematologic or psychiatric disorder

Keywords: endometriosis,infertility,in vitro fertilization
effect of varying testosterone levels on insulin sensitivity in men with idiopathic hypogonadotropic hypogonadism (ihh)

Conditions: Hypogonadotropic Hypogonadism; Kallmann Syndrome

Summary: the investigators are doing this research study to look at the relationship between testosterone (the main sex hormone in men) and insulin (the hormone that controls blood sugar levels) in men with idiopathic hypogonadotropic hypogonadism (ihh). the investigators hypothesize that normalizing testosterone levels in men with ihh enhances insulin sensitivity, reduces visceral fat, increases lean body mass, and improves the lipid profile.


Eligibility criteria:
inclusion criteria: * diagnosis of idiopathic hypogonadotropic hypogonadism or kallmann syndrome * mean testosterone level less than 300 ng/dl * stable weight for the previous 3 months (no weight change greater than or equal to 10 lbs) * normal serum tsh * normal serum prolactin levels exclusion criteria: * type 2 diabetes mellitus * history of diabetes in parents * sleep apnea * bleeding disorder * seeking fertility * 2 or more cardiovascular risk factors: smoking, hypertension, diabetes, dyslipidemias, family history of cardiovascular disease before age 60. * history of previous cardiovascular event: myocardial infarction, unstable angina, cerebro-vascular accident. * illicit drug use/alcohol use (\>4 drinks per day)

Keywords: ihh ks idiopathic hypogonadotropic hypogonadism gnrh deficiency
accuracy of contrast enhanced mamography in predicting response of breast cancer post neoadjuvant chemotherapy

Conditions: Breast Cancer

Summary: the aim of this work to evaluate the accuracy of contrast enhanced spectral mamography in predicting the response to nac and assessment of residual disease in breast cancer patients

this a prospective series ,will be performed for 50 patients diagnosed by biopsy as breast cancer who will be scheduled for surgery after completing the full coarse of neoadjuvant chemotherapy

Eligibility criteria:
inclusion criteria: * patient confirmed diagnosed by early breast cancer decided to received neoadjuvant treatment * locally advanced breast cancer * operable metastatic breast cancer exclusion criteria: * patient not candidate for nac * contrast allergy * renal impairment * pregnancy