Kornimate/medical-research-clean huggingface dataset:
the roles of prostanoids in patients with sleep apnea syndrome

Conditions: Sleep Apnea

Summary: the purpose of this study is to evaluate the relationships between prostanoids and various outcomes such as sleep disturbance, hypertension and arteriosclerosis in patients with sleep apnea syndrome(sas). in the patients introduced to continuous positive airway pressure(cpap) treatment, the effects of cpap are also evaluated.

sas is characterized by abnormality during sleep and hypoxemia from apnea and hypopnea, followed by systemic inflammation and organ dysfunction like cardiovascular diseases. systemic inflammation causes the activation of arachidonic acid metabolism, producing prostaglandins (pgs) and leukotrienes (lts). in addition, significant relationships between pgd2 and pge2 and sleep, pgf2α and hypertension, pgi2 and thromboxane and platelet aggregation and so on are reported. therefore, it is hypothesized that many prostanoids affect the pathophysiology of sas. however, the relationships between prostanoids and clinical outcomes in patients with sas are unknown. although cpap is the major treatment of sas, the effects of cpap on prostanoids are not known, either. thus, the purpose of this study is to evaluate those relationships.

Eligibility criteria:
inclusion criteria: * subjects hospitalized in kyoto university hospital for careful examination of sas exclusion criteria: * subjects with severe respiratory diseases, severe heart diseases, severe vascular diseases, or severe diabetes mellitus. * subjects taking nonsteroidal anti-inflammatory drugs, steroids or immunosuppressants.

Keywords: sleep apnea syndrome cpap prostanoids
thermal camera detection of ventriculoperitoneal shunt flow

Conditions: Hydrocephalus

Summary: there have been reports in the past of using thermal cameras to demonstrate flow in the tubing as a surrogate of proper shunt function. this was shown to have almost 90% accuracy at determining proper functioning but required expensive equipment that was not universally available. there is now smart phone based thermal camera technology (flir one: http://www.flir.com/flirone/) that could make this technique widely available for health care use. the goal of the study is to determine if this device can demonstrate flow in the distal tubing of a vp shunt.


Eligibility criteria:
inclusion criteria: * patients with known vp shunt * status of shunt function known. * patients with well healed wounds (no immediately post op patients) exclusion criteria: * patients in urgent need of shunt revision * age less than 18
compression headband use to prevent hair loss during whole brain radiotherapy

Conditions: Alopecia

Summary: this study hypothesizes that in patients undergoing whole brain radiotherapy, a compression headband will decrease the percentage of patients with significant hair loss following radiation.

this is a pilot feasibility study. the primary objective of this study is to seek preliminary information to answer the following question: 1. does a compression headband, placed only at the time of irradiation, reduce the incidence of significant hair loss after whole brain radiation, as compared to historical controls? this study will also seek to answer these secondary questions: 2. is a temporary compression headband well tolerated in patients undergoing whole brain radiation? 3. if a portion of patients do have significant hair loss after radiation in spite of compression banding, what is the timing of hair regrowth? 4. in normal volunteers, does a compression headband cause acute hypoxia in the scalp, as measured by a transcutaneous oxygen pressure monitor, and, if so, to what degree?

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years old. * undergoing whole brain radiation therapy, using lateral opposed fields * total planned radiation prescription dose between 30 gy and 37.5 gy in 10 to 15 treatments. exclusion criteria: * current complete or near-complete alopecia (natural or chemotherapy-induced) * concurrent or sequential chemotherapy with an agent known to commonly cause alopecia (adriamycin, cytoxan, ifosfamide, taxol (greater than 50 mg/m2), or vincristine). * previous radiation to the scalp * any active dermatologic disease affecting the scalp, or temporal arteritis * history of severe headaches.

Keywords: alopecia radiotherapy
effect of remote ischemic perconditioning on acute kidney injury in adult valve replace

Conditions: Rheumatic Disease of Heart Valve; Ischemic Reperfusion Injury

Summary: the purpose of this study is to determine whether remote ischemic perconditioning is effective on acute kidney injury in adult valve replacement.

methods: patients meeting the requirement will be randomized into 2 groups: the treatment group consisted of three 5-minute cycles left lower limb ischemia, induced by inflating a blood pressure cuff on the lower limb to 600 mmhg with an intervening 5 minutes of reperfusion, during which time the cuff was deflate; the control group consisted of placing an uninflated cuff on the left lower limb for 30 minutes. the postconditioning protocol was applied after the aortic cross-clamping. the clinical data of inotropes requirement, drainage, ventilation and intensive care time will be recorded. venous blood samples will be taken perioperatively for detecting concentration of troponin i (ctni), myocardial enzyme, renal function, cystatin c, and high-sensitivity c-reactive protein(hs-crp).

Eligibility criteria:
inclusion criteria: * rheumatic heart valve disease requiring selective aortic or double valve(aortic and mitral valve) replacement exclusion criteria: * infective endocarditis congenital valve disease previous cardiac surgery complicated with rereplace valve * renal dysfunction * diabetes * coronary artery disease * hypertension * peripheral vascular disease affecting the lower limb free of arteriovenous fistula * receiving aspirin, corticosteroids, angiotensin-converting enzyme inhibitors or statin perioperatively

Keywords: ischemia reperfusion injury cardiopulmonary bypass remote ischemic postconditioning other functional disturbances following cardiac surgery
efficacy of acupuncture in patients with lower extremity amputation with neuroma

Conditions: Neuroma Amputation

Summary: neuroma often occurs after major nerve damage or transection and can be diagnosed with pain at the tip of the stump, positive tinel, imaging (usg/mr). various treatment methods are used for neuropathic pain, including pharmacological agents, intralesional steroid and local anesthetic injection, alcohol, phenol, radiofrequency or cryotherapy, ablation and surgical applications. exercise (rom and relaxation), tens, biofeedback, hypnosis, acupuncture, psychotherapy, mirror therapy can be used in the treatment of neuropathic pain in amputees. in this study, the investigators aimed to examine the effectiveness of acupuncture on pain, neuroma size and functional status in individuals with lower extremity amputation with neuroma.

the study was designed as a prospective, randomized, controlled trial. thirty six people who met the inclusion criteria will randomized into two groups of 18 people. the first group will be designated as acupuncture therapy group and patients in the second group will be designated as the control group. patients will be evaluated with visuel analog scale (10cm-vas), lanss (self-leeds assessment of neuropathic symptoms and sign) scale, locomotor capacity index, 2-minute walking test, usg measurement. the patients will be evaluated at the beginning of the treatment (0.month), the end of the treatment (1st month), and the 4th month.

Eligibility criteria:
inclusion criteria: * 18 years or older * having a diagnosis of lower extremity amputation * consent to be included in the study * having a complaint of pain exclusion criteria: exclusion criteria for the acupuncture+tens group * conditions in which acupuncture is strictly contraindicated (inflamed, infected or impaired skin, spontaneous bleeding, metal allergy, fear of needles, unstable diabetes mellitus patients, history of unstable epilepsy or unexplained convulsions, unstable acute cardiac arrhythmia or heart failure , heart valve disease or history of replacement surgery, presence of lymphedema) * lack of consent to be included in the study * there are situations where tens application is inconvenient exclusion criteria for only tens group * there are situations where tens application is inconvenient * lack of consent to be included in the study

Keywords: lower extremity amputation with neuroma acupuncture
heart analysis in gated-pet in patients having a gallium-68-dotatoc pet/ct exam for oncology indication

Conditions: Cardiac Inflammation

Summary: gallium-68-dotatoc binds primarily with high affinity to somatostatin subtype 2 (sstr2) receptors and these somatostatin receptors are also overexpressed on inflammation cells when activated. the hypothesis is that the gated mode on a gallium-68-dotatoc cardiac recording would be able to highlight abnormalities that could be correlated with the age of the patients and their cardiovascular risk factors.

people with the selection criteria for the study, coming to the nuclear medicine department in order to benefit from a gallium-68-dotatoc pet/ct exam as part of a diagnostic or pre-therapeutic assessment of a neuroendocrine tumor will be offer to participate in the study after sign consent, patients were install in a room to have blood drawn for troponin ic, bnp and crp and after gallium-68-dotatoc infusion gallium-68-dotatoc pet/ct will be recorded and immediately the cardiac record in gated mode

Eligibility criteria:
inclusion criteria: persons who have received complete information on the organization of the research and who have signed the informed consent and: * age ≥ 18 years old. * having read and understood the information document. * affiliated to a social security scheme. person for whom a 68ga-dotatoc pet/ct exam is requested as part of the diagnostic or pre-therapeutic assessment of a neuroendocrine tumour. exclusion criteria: person with * hypersensitivity during previous use of 68ga-dotatoc * impossibility of performing a pet-ct (patient agitated, confused, etc.). * history of heart disease, * severe arrhythmia that does not allow the pet synchronized with the ecg * severe renal insufficiency (gfr \<30 ml/min/1.73 m2) * treated with a somatostatin analogue. * cushing's syndrome * pregnant woman, likely to be or breastfeeding * adult subject to a legal protection measure (guardianship, curators, legal safeguard) * person of legal age unable to express their consent * person deprived of liberty by a judicial or administrative decision * person, subject to psychiatric care under articles l. 3212-1 and l. 3213-1
tele-yoga and dystonia

Conditions: Cervical Dystonia

Summary: the purpose of this study is to investigate the effect of yoga delivered remotely on adults with dystonia. this work will have implications related to physical interventions symptom management and quality of life as well as implications related to the role of tele-therapy.

this is a single group intervention study of adults (18-80 years-old) with dystonia symptoms undergoing a 6-week intervention of 30 minute yoga classes delivered remotely through videoconferencing 2-3 times a week. subjects with cervical dystonia will complete yoga classes delivered at-home with videoconferencing, receiving one-on-one yoga instruction including breathing, postures, and meditation/relaxation for two to three times a week. data collection will occur remotely via videoconferencing at 0-weeks (baseline), 6-weeks (after the intervention), and 12-weeks (follow-up). data collection will include demographics, mental health questionnaires, motor assessments, enjoyment, usability, and follow-up yoga status. each yoga session will be video recorded to aide in recording adherence, adverse events, and challenges.

Eligibility criteria:
inclusion criteria: 1. a diagnosis of cervical dystonia 2. 18-80 years old 3. ability to communicate verbally and follow directions 4. english-speaking 5. subject has access to wifi and applicable technological device (computer, laptop, tablet, smartphone etc) 6. subject is willing to be video recorded during the yoga session 7. subject is willing to open zoom on their technological device 8. subject feels comfortable using a technological device for the intervention (ie demonstrates self-reported technological literacy) 8) if they are a u.s. resident, they must be a new jersey resident and will participate in a majority of the intervention sessions from new jersey. international enrollment will be considered on a case-by-case basis based on the physical therapy licensure regulations of the appropriate physical therapy board. exclusion criteria: 1. diagnosis of major depressive disorder, 2. injury or condition that could prevent the ability to engage in yoga poses based on self-report 3. cognitive impairment or condition that would prevent the subject from understanding the tasks or communicating with the research team 4. past yoga experience exceeding 5 or more times within the last 2 months 5. pregnant women 6. no access to a technological device (such as a smartphone, computer, laptop, or tablet) or access to wifi that can be used to access the teleconferencing medium 7. if the subject does not want to be recorded during the yoga sessions

Keywords: yoga cervical dystonia telerehabilitation
inflammatory biomarkers predict pulmonary outcomes in coronary artery bypass grafting

Conditions: Coronary Artery Disease; Chronic Obstructive Pulmonary Disease

Summary: the primary objective of this pilot study is to identify and quantify inflammatory and genetic markers from bronchoalveolar lavage fluid (balf) and serum in patients with a history of chronic obstructive pulmonary disease (copd) undergoing elective coronary revascularization (cabg) to determine the risk of developing post operative respiratory failure. to achieve this objective, this proposal outlines the following specific aims: aim #1. to identify from balf and serum, the change in inflammatory and genetic markers in patients with a history of copd undergoing cabg. balf and serum samples will be obtained at the time of intubation immediately prior to surgery and again upon skin closure immediately after the surgical procedure. aim #2. to determine the extent to which inflammatory and/or genetic markers correlate with post-operative pulmonary complications defined as prolonged mechanical ventilation (\> 24 hours), pneumonia, and/or tracheostomy. aim #3. to inform the development and implementation of a large pivotal trial which may impact clinical decision-making during the initial pre-operative outpatient assessment of copd patients undergoing cabg.


Eligibility criteria:
inclusion criteria: * undergoing elective cabg * current diagnosis of copd * ability to provide signed informed consent to participate * \> 18 years of age exclusion criteria: * concomitant valve surgery * urgent or emergent coronary surgery * current steroid therapy * active smoker and/or positive urine co-nicotine

Keywords: coronary artery bypass grafting coronary artery disease chronic obstructive pulmonary disease
impact of eplerenone on cardiovascular outcomes in patients post myocardial infarction

Conditions: Myocardial Infarction

Summary: administration of eplerenone within 24 hours of onset of symptoms of myocardial infarction, in patients without heart failure, reduces cardiovascular mortality / morbidity.


Eligibility criteria:
inclusion criteria: * subjects must have experienced a myocardial infarction (stemi) within the previous 24 hours confirmed by symptoms and ecg. exclusion criteria: * subjects with a known low ejection fraction of less than 40% or any previous history of heart failure. * subjects treated with eplerenone or other aldosterone antagonists within the past 1 month. * the subject has uncontrolled hypotension (sbp\<90mmhg). * subjects with egfr ≤30ml/min (based on admission serum creatinine and the mdrd formula) or serum creatinine ≥220µmol/l.

Keywords: eplerenone myocardial infarction mortality morbidity
advancing the science of pediatric interstage home monitoring

Conditions: Heart Defects, Congenital

Summary: the overall goal of this study is to understand the feasibility of using a wireless sensor device (instead of a wired device) to collect information used to monitor children with heart conditions at home.

the goal of this study is to examine how well continuous sensor-based monitoring performs at detecting physiologic data in infants with single ventricle physiology at home compared to existing approaches, in manner that is feasible and acceptable to patients' families. performance features of interest include how the data compares to family measurements, whether it correlates with parents' observable symptoms, and how this approach may be integrated into home life and health system workflows. the investigators will also explore whether the collected data can be used to develop predictive analytics for acute deterioration and/or advanced chronic cardiopulmonary management compared to what is currently being done in remote patient monitoring.

Eligibility criteria:
inclusion criteria: * receiving active remote patient monitoring (rpm) in lurie's tele-interstage home monitoring program. * age 0-2 years of age at enrollment. * in the opinion of the investigator, parent or legally authorized guardian, and participant, the participant and (when relevant) family can follow study procedures. exclusion criteria: * is going to discontinue rpm before their enrollment would end (i.e., within 14 days). * skin breakdown or severe rash at the site of sensor placement. * patient without a parental guardian to consent. * the patient is in active hospice or similar end-of-life care. * the patient will be living in a long-term institution or transitional facility.

Keywords: heart defects, congenital digital health
efficacy and safety of eplivanserin treatment for sleep maintenance insomnia

Conditions: Sleep Initiation and Maintenance Disorders; Insomnia

Summary: the purpose of the study is to assess efficacy and safety of eplivanserin in the population of patients complaining of sleep maintenance insomnia. the patients suffering from that condition frequently wake up during the night, their sleep is nonrestorative and they suffer from a significant distress or impairment in their daily activities consecutive to insomnia.

12 weeks for each patient (double-blind period) + 1 week of run-in (placebo), and 2 weeks of run-out (placebo) total duration of observation: 15 weeks for each patient

Eligibility criteria:
inclusion criteria: * out patients * each patient must have primary insomnia in accordance with dsm-iv-tr-axis i (diagnostic and statistical manual of mental disorders- fourth edition-text revision) criteria * based on patient's information, the patient must complain of at least one hour of wakefulness after sleep onset for at least 3 nights per week over the preceding month * patient must report impact daytime functioning associated with sleep maintenance insomnia as measured by question 3 of insomnia severity index at screening visit and randomization visit. exclusion criteria: * females who are lactating or pregnant * woman of childbearing potential with a positive serum beta human chorionic gonadotropin pregnancy test at screening and not using an acceptable form of contraception * patients presenting with acute or chronic pain resulting in insomnia * patients with history of epilepsy or seizures * consumption of xanthine containing beverage (i.e. tea, coffee, or cola) comprising more than 5 glasses/day * evidence of any clinically significant, severe, or unstable acute or chronically progressive medical or surgical disorder which may affect patient safety * bmi \>32 * acute or chronic pain resulting in insomnia * patients with current psychiatric disorders according to dsm-iv-tr criteria, mental retardation, or dementia * clinically significant and abnormal ekg (qtc interval \>=500 msec) * positive for hepatitis b or c * serious head injury or stroke within 1 year * use of otc (over-the-counter) medications such as valerian root, kava, melatonin, st. john's wort, or alluna; prescription sleep medications or anxiolytics within 1 week or 5 half-lives * participation in another trial within two month before the screening visit * use of any substance with psychotropic effects or properties known to affect sleep/wake * unable to complete the study questionnaires * night shift workers, and individuals who nap 3 or more times per week over the preceding month * history of: * primary hypersomnia * narcolepsy * breathing-related sleep disorder (such as sleep apnea) * circadian rhythm sleep disorder * parasomnia (somnambulism) * dyssomnia (such as periodic leg movements)

Keywords: primary insomnia sleeplessness early awakening chronic insomnia
war on melanoma™ public health & education campaign

Conditions: Melanoma

Summary: this trial studies how well a health educational campaign works in increasing early detection of melanoma in oregon. the health educational campaign may provide information to help people learn about the early signs of melanoma. increased education in oregon may decrease the number of people who die from melanoma and increase the number of melanomas that are identified at an earlier stage.

primary objectives: i. to measure the change in melanoma literacy in oregon, washington, and utah over five years (relative to baseline) and determine if there is a statistically significant difference in literacy in oregon (where the educational campaign occurred) as compared to the non-participating states (washington and utah). ii. to determine if there is an association between melanoma literacy and 1) stage at diagnosis, 2) tumor depth, 3) incidence, and 4) mortality rates in oregon, washington, and utah. iii. to determine if the cost of care for melanoma in oregon is impacted by melanoma literacy and/or tumor stage. outline: media campaign: participants view digital media strategies. primary care providers and professionals: primary care providers and professionals who see skin and potential melanomas receive online based curriculum on melanoma. participants also complete a survey to assess knowledge and confidence before and after receiving the curriculum. melanoma community registry volunteers: melanoma community registry volunteers in oregon receive educational and training materials on melanoma. participants also complete a survey before and after receiving educational material. high school students: high school students receive an educational lecture over 1 hour on sun-safety and early detection of melanoma practices. participants also complete a survey before and after the educational lecture.

Eligibility criteria:
inclusion criteria: * individuals, melanoma patients, skin service providers and health care providers interested in awareness and educational campaign exclusion criteria: * no one will be intentionally excluded