Kornimate/medical-research-clean huggingface dataset:
efficacy and safety study of adefovir and entecavir for elderly with chronic hepatitis b

Conditions: Hepatitis B, Chronic

Summary: it is estimated that 350-400 million people have chronic infection with hepatitis b virus (hbv) all over the world. in china, 93 million individuals suffer from this chronic condition. currently, seven medications are approved for the treatment of hepatitis b: two formulations of interferon and four nucleos(t)ide analogues. the chinese population has one of the longer average life spans, and the size of the aged population has been increasing rapidly. as a result, the prevalence of elderly patients with hbv has increased, and the potential for development of cirrhosis or hepatocellular carcinoma in such patients is real. hence, treatment of elderly patients with hbv is an important issue. however, adv or etv has become first choice due to the more side effect of inf and the resistant of lam and ldt. but treatment outcomes with adv and etv in elderly are not known yet. in this study, we will evaluate and compare the efficacy and tolerability of adv and etv between younger and older patients with hbv. the aims of the present study are (1)to assess the benefits of adv or etv therapy for elderly patients with chronic hepatitis b, and (2)to determine differences in the emergence rate of side effect.


Eligibility criteria:
inclusion criteria: 1. age≥18 years 2. hbsag positive for more than 6 months before enrollment 3. serum hbvdna \>2×104iu/ml and serum alt \>80u/l or tbil \< 34 umol/l for chronic hepatitis b 4. serum alt \< 80u/l, but hepatic inflammation scores ≥ g2 or hepatic fibrosis stage ≥ s2 for chronic hepatitis b 5. serum hbvdna \>40 iu/ml for cirrhosis regardless of alt and tbil exclusion criteria: 1. co-infected with hcv, hdv or hiv, or autoimmune liver diseases combined 2. received antiviral therapy or immunosuppressant drugs before 6 months prior to enrollment 3. renal function: creatinine \>1.5 uln or egfr\< 50ml/min/1.73m2 before therapy 4. combined with hepatocarcinoma before therapy 5. suspend therapy voluntarily 6. use other nephrotoxic drugs

Keywords: aged hepatitis b, chronic antiviral agents
qualitative study of suicidal recrudescence among adolescents in november 2021

Conditions: Suicide; COVID-19

Summary: a qualitative study, combining psychiatric and anthropological perspectives, focused on the lived experiences of patients who had recourse to hpncl emergencies during the period of november 2021, as well as the experiences and perceptions of those around them - such as their family, teachers or school and nursing staff. this multi-site approach will provide a multidimensional perspective on the experience of individuals and those around them, as well as a triangulation of data. the hypotheses to explain the increase in the rate of suicidal crisis will be addressed through semi-structured interviews proposed to the participants of the study.

interviews in the presence of two members of the research team (child psychiatrists, psychologists, anthropologists, etc.) will be offered to participants. these interviews will be face-to-face when possible, but can also be done remotely, by teleconsultation, depending on the preferences of the participants. these interviews will be based on a questionnaire established beforehand evoking the history of mental disorders and the experience of the participant in the study and his entourage of the covid-19 health crisis. all information exchanged during these interviews will be made anonymous (data collected and processed as well as the results presented). they will be used exclusively in the context of the study and not communicated to the medical team involved in the patient's care. the proposed interviews will be carried out separately with: * the patient who consulted the emergency room during the month of november 2021 * the parent(s) of the study participant * one or more health professionals taking care of the patient * the school attended by the patient who will be questioned about the suicidal problem and covid-19 in general or not about the patient in particular. * child welfare professionals (ase) potentially involved in the care of the study participant. questionnaires will also be carried out with patients in order to complete the assessment of their clinical condition at a distance from the psychological crisis:

Eligibility criteria:
inclusion criteria: * any patient having consulted in the child psychiatric emergency room of the hpncl between november 1, 2021 and november 30, 2021 for suicidal thoughts. * age between 13 years and 17 years and 11 months * good understanding of written and oral french * collection of the informed consent of the patient and of one of the two parents or holder of parental authority exclusion criteria: * inability to comply with the instructions defined and exposed during inclusion * refusal of participation by the patient or one of the legal guardians

Keywords: pediatric
three year evaluation of a cohort of patients presenting osteoporotic fractures

Conditions: Osteoporosis; Osteoporotic Fractures

Summary: a specialized osteoporosis clinic has existed in our hospital since 2010. the descriptive retrospective analysis of patients included in this pathway was the subject of a first study on patients included between january 2010 and january 2011 and reported to the congress of the french society of rheumatology (sfr) in december 2011, then a second study on patients included between january 2012 and december 2016, presented as an e-poster at the sfr congress in december 2017 and in a poster at the american society of bone and mineral research conference (asbmr) in october 2018 and published in 2019 in archives of osteoporosis. the effectiveness specialized osteoporosis clinics is the subject of numerous publications. it therefore seems important to evaluate the effectiveness of our management, 3 years from the date of inclusion of patients in the osteoporosis clinic of our hospital.


Eligibility criteria:
inclusion criteria: * patients who had an osteoporotic fracture followed by the osteoporosis clinic since between january 2012 and december 2015 * acceptation of the telephone interview exclusion criteria: * age \< 18 years * no social security coverage
feasibility of rus lung in mits

Conditions: Lung Cancer

Summary: this sponsor-initiated prospective observational study aims to demonstrate the feasibility and efficacy of rus lung surgical navigation system in patients undergoing minimally invasive thoracic surgery(mits). the trial will enroll 36 patients who undergo video-assisted or robot-assisted thoracoscopic surgery using rus lung. the study will be conducted across two medical centers." * investigational medical device: rus lung (endoscopic imaging treatment planning software) * clinical trial duration: 12 months from irb approval * target number of subjects: total of 36 participants

patients will be enrolled after being selected based on the inclusion and exclusion criteria and after obtaining informed consent. video-assisted or robot-assisted thoracic surgery (vats/rats) will be performed using rus lung.parameters-associated with operation or clinical outcomes will be evaluated during hospitalization period or through outpatient follow-ups for up to 2 weeks after discharge. the operative outcomes including operative time, estimated blood loss, complication rates, and hospital length were compared with the historical control underwent vats and rats without using rus lung.

Eligibility criteria:
inclusion criteria: * individuals who were diagnosed with lung caner (tumor size≤3cm) * individuals aged 19 or older * individuals who who are able to undergo ct imaging according to the established protocol * individuals who have voluntarily given written consent to participate in this clinical trial exclusion criteria: * vulnerable subjects * individuals who who are not able to undergo ct imaging according to the established protocol * individuals who are expected to have severe adhesions * individuals who are unable to follow the study procedures and are deemed inappropriate for participation

Keywords: lung cancer 3d model 3 dimensional segmentectomy robot-assisted thoracoscopic surgery video-assisted thoracoscopic surgery
evaluation of sepsis-induced immunosuppression base on quantiferon monitor® in septic shock

Conditions: Septic Shock

Summary: quantiferon monitor® is an immunological test evaluating the nonspecific cellular response by measuring interferon gamma (ifnγ) secretions after t-cell and natural killer lymphocyte stimulation. this study aims at evaluating sepsis-induced immunosuppression base on quantiferon monitor® in patients presenting to the intensive care unit for septic shock. the sponsor expects to identify sepsis-induced immunodeficiency in patients through a better understanding of cellular and adaptive immune responses.

a sepsis-induced immunosuppression phase has recently been characterized and has been associated with worse outcomes as well as increased healthcare costs. furthermore, a marked suppression of the immune response has been partially described in patients hospitalized in the intensive care setting but its monitoring is not available in daily practice. quantiferon monitor® is an immunological test evaluating the nonspecific cellular response by measuring interferon gamma (ifnγ) secretions after t-cell and natural killer lymphocyte stimulation. several studies have shown the pertinence of this test, especially in patients with kidney failure requiring renal replacement therapy. patients with lower ifnγ levels were also found to be at higher risk of infection. this study aims at evaluating sepsis-induced immunosuppression base on quantiferon monitor® in patients presenting to the intensive care unit for septic shock. the sponsor expects to identify sepsis-induced immunodeficiency in patients through a better understanding of cellular and adaptive immune responses. this should ultimately lead to determining thresholds for sepsis-related complications and identifying patients most at risk of sepsis-induced immuno-depression.

Eligibility criteria:
inclusion criteria: * patient hospitalized in intensive care and intensive care at nice university hospital and presenting with septic shock (defined by the presence of sepsis, the need for a vasopressor to maintain a map\> 65mmhg and hyperlactatemia\> 2mmol / l) * free and express informed consent signed by the patient or the confidential counselor in case of impossibility (deferred consent of the patient as soon as his condition allows it) * age\> 18 years old * affiliated to a social security scheme exclusion criteria: * pregnant woman patient under the age of 18 * patient under guardianship or curatorship or placed in detention * patient with congenital or previously acquired immune deficiency * patient on prior immunosuppressive treatment
characteristics and predictors of progression of an egyptian multiple sclerosis cohort

Conditions: Multiple Sclerosis

Summary: initial recruitment: 1717, 136 (7.92%) were excluded due to missing data that could not be obtained. the diagnosis of multiple sclerosis (ms) was revised according to the 2010 revision of the mcdonald criteria. patients analyses: 1581 every patient was registered by his/her 14-digit unique identity numbers, (which is mandatory in egypt since 1999) to make sure that every registered patient in different centers were counted only once.

patients' records review procedure and sampling strategies. the medical records, administrative data, laboratory and diagnostic tests reports were screened by 3 authors (hs, ns, ae) and these data were extracted in a standard electronic form according to kasr alaini multiple sclerosis unit (kamsu) registry. an assigned coordinator from each center was requested to facilitate data collection from site-specific records. in cases of incomplete documentation or unclear information, verification was done by on-site data coordinator either by phone contact or face-to-face interview with the patients, whether during the routine follow up or in an unscheduled visit. several measures were taken to ensure the confidentiality of the collected information. no patient names were included in the database presented by site coordinator, and the study staff signed a confidentiality agreement for non-disclosure.

Eligibility criteria:
inclusion criteria: * all patients with suspecting multiple sclerosis attending 4 tertiary referral centers in egypt exclusion criteria: * missing data that could not be obtained
web-based support for family caregivers of patients with advanced cancer

Conditions: Family; End of Life; Cancer Metastatic; Chronic Illness

Summary: for family caregivers of patients with advanced cancer, preparedness for caregiving is crucial for maintaining health and quality of life both during care and after the death of the patient. this project contributes to earlier research funded by the swedish cancer society, about an intervention that was delivered by a multi-professional team and proved to be successful in promoting preparedness. however, such interventions are often costly and logistically challenging. in addition, the covid-19 pandemic has further significantly raised the need for digital alternatives in healthcare. as a possible solution, an evidence-based intervention, narstaende.se, has been developed consisting of recorded videos of conversations between clinicians and family caregivers (actors), linked to informational texts and a moderated chat forum. the intervention was pilot tested during 2020 and 2021, exploring feasibility, content and family caregivers' experiences. as preliminary results are promising, the intervention is taken one step further and tested as a web-based intervention in a larger scale.


Eligibility criteria:
inclusion criteria: * being a family caregiver, over 18 years of age, to a person with life-threatening illness cared for in specialized home care. exclusion criteria: * not being able to communicate in swedish

Keywords: palliative care family caregiver web-based support intervention
feasibility testing of a tai chi program for chemotherapy-induced peripheral neuropathy treatment (tct)

Conditions: Chemotherapy Induced Peripheral Neuropathy (CIPN); Peripheral Neuropathy Due to Chemotherapy; Peripheral Neuropathies

Summary: this research is being done to determine whether a 12-week virtual tai chi training program, designed to improve balance and small nerve fiber function, is feasible and acceptable among cancer survivors with chemotherapy-induced peripheral neuropathy (cipn).

this is a prospective, randomized, waitlist-controlled pilot trial to examine the suitability of the virtual tai chi program in cancer survivors with cipn. tai chi is a mind-body practice that involves gentle body movements, meditation, and breathing techniques. it has proven to be effective in enhancing balance control and relieving musculoskeletal pains. this study randomly assigns cancer survivors with cipn with self-perceived balance difficulties to one of two groups: group a tai chi group versus group b waitlist group. randomization means a participant is placed into a study group by chance. the research study procedures including screening for eligibility, questionnaires, and sensory and functional testing. participation in this study is expected to last for up to 12 weeks. it is expected that about 21 people will take part in this research study.

Eligibility criteria:
inclusion criteria: * age \> 18 years old * cancer survivors with no evidence of disease (cancer); * completed neurotoxic chemotherapy, i.e., platinum agents, taxanes, vinca alkaloids, and bortezomib, at least three months before enrollment; * a cipn diagnosis based on symptom history, loss of deep tendon reflexes, or presence of symmetrical stocking-glove pain, numbness, or paresthesia; * answers "yes" to the following question: "do you feel as though your balance is affected from experiencing cipn?" "are you afraid of falling as a result of your cipn?"; * on a stable regimen (no change in past three months) if taking anti- neuropathy or other pain medications; and * ecog performance status scale score ≤ 2 * willing to adhere to all study-related procedures, including randomization to the tai chi or waitlist group, two separate in- person visits to dfci and osher center within 2 weeks of enrollment, and separate in-person visits to dfci and osher center at week 12, and no new pain medication allowed throughout the study period. note: participants receiving endocrine therapy or targeted/antibody therapy (examples including trastuzumab, perturzumab, immunotherapy) will be eligible. exclusion criteria: -patients who have received physical therapy or tai chi training, specifically for cipn, in the past three months.

Keywords: peripheral neuropathy chemotherapy induced peripheral neuropathy
an eight-week randomized,double-blind study to evaluate the efficacy and safety of fixed-dose combinations of t80+a5 versus a5 monotherapy in patients with hypertension who fail to respond adequately to treatment with a5 monotherapy

Conditions: Hypertension

Summary: the primary objectives of this trial is to demonstrate that the fixed-dose combination of telmisartan 80mg plus amlodipine 5mg (t80/a5) is superior to amlodipine 5mg (a5) in reducing seated trough diastolic blood pressure (dbp) at 8 weeks.


Eligibility criteria:
inclusion criteria: 1. diagnosis of essential hypertension 2. failure to respond adequately to six weeks treatment with amlodipine 5 mg monotherapy 3. provision of written informed consent exclusion criteria: 1. clinical conditions which, in the opinion of the investigator, would not allow safe completion of the protocol and safe administration of telmisartan and amlodipine for the planned duration of this trial (e.g. populations where labeling of either product recommends against its utilization)
effects of increased tidal volume on internal jugular vein cross-sectional area

Conditions: General Anesthesia; Surgery

Summary: as increasing tidal volume, the cross sectional area and circumference of internal jugular vein (ijv) could increase. and in the previous study, trendelenburg position can increase size of ijv. so investigators would compare the cross sectional area, circumference of ijv and peak airway pressure in neutral and trendelenburg position


Eligibility criteria:
inclusion criteria: * patients who are undergoing general anesthesia exclusion criteria: * history of ijv cannulation * uncontrolled cardiovascular disease * severe pulmonary problem * cervical spinal impairment

Keywords: any operation that required for general anesthesia
en3835 for the treatment of edematous fibrosclerotic panniculopathy (commonly known as cellulite)

Conditions: Edematous Fibrosclerotic Panniculopathy; Cellulite

Summary: a phase 2, open-label extension study of en3835 in the treatment of edematous fibrosclerotic panniculopathy (commonly known as cellulite).


Eligibility criteria:
inclusion criteria for observation phase: * voluntarily sign and date an informed consent agreement * have participated in and completed the double-blind study en3835-201 * be willing to apply sunscreen to any treated quadrant before each exposure to sun inclusion criteria for treatment phase: * voluntarily sign and date an informed consent agreement * have participated in and completed the double-blind study en3835-201 * be willing to apply sunscreen to any treated quadrant before each exposure to sun * have at least 1 quadrant with: a score of 3 or 4 (moderate or severe) as reported on the pcss (photonumeric cellulite severity scale) by the subject or investigator, and a hexsel css (cellulite severity scale) score no greater than 13 * be judged to be in good health * have a negative urine pregnancy test at screening and be using an effective contraception method, be surgically sterile, or post-menopausal exclusion criteria for observation phase: * none exclusion criteria for treatment phase: * has used, or intends to use during the course of the study, other treatment of efp on the legs or buttocks * is presently nursing a baby or providing breast milk for a baby * intends to become pregnant during the study * currently receiving, has received within 7 days before injection of study drug, or plans to receive an anticoagulant or antiplatelet medication * history of stroke or bleeding
the philippine neurological association one database -dementia

Conditions: Cognitive Impairment; Dementia; Mild Cognitive Impairment

Summary: this is a pragmatic, multi-center, prospective, observational, non-interventional study and standing database of patients seen at the training institution for cognitive impairment diagnosed with mild cognitive impairment (mci) or dementia. all patients seen at the training institution clinically diagnosed with mci or dementia by their neurologists will be invited to participate in the study. the investigators will confirm the diagnosis and will explain the study as well as the patient information sheet to the patient and/or legal representative. all eligible patients seen will be assigned a study identification number. data will be collected by the investigators as the patient undergoes routine clinical evaluation. corresponding anonymized data on demographics, medical history and risk factors, level of functional impairment, diagnosis, baseline cognitive scores and management will be collected from each patient and entered in the database using a secure online data collection tool.

the investigators will confirm the diagnosis and will explain the study as well as the patient information sheet to the patient and/or legal representative. all eligible patients seen will be assigned a study identification number. data will be collected by the investigators as the patient undergoes routine clinical evaluation. corresponding anonymized data on demographics, medical history and risk factors, level of functional impairment, diagnosis, baseline cognitive scores and management will be collected from each patient and entered in the database using a secure online data collection tool. patients who withdraw participation verbally or in writing are excluded by the investigator from further participation. withdrawal from the study will be properly documented, including date, time, and reason for withdrawal. withdrawn subjects will not have their clinical data included in the database. collective data will be extracted, summarized, and analyzed every year with oversight provided by the philippine neurological association (pna). to be able to assess trends and changes over time, data collection for this study will span 3 years from study initiation, after which the utility of an extension or a re-implementation of the study will be assessed by the pna.

Eligibility criteria:
inclusion criteria * patient with cognitive impairment diagnosed with mild cognitive impairment or dementia. * 18 years old or older. * must be a filipino citizen. * seen and evaluated in the participating hospital by a neurologist. * if required by the institutional review board/ethics committee, signed or verbal informed consent for participation in the study from the patient or a legal representative. exclusion criteria • any condition which, in the study investigator's opinion, may jeopardize the patient by his/her participation in this study or affect the validity of the study results.