Kornimate/medical-research-clean huggingface dataset:
rheupp - a rheumatological follow-up management app

Conditions: Rheumatoid Arthritis

Summary: the purpose of this non-inferiority randomized clinical trial is to evaluate the effectiveness of rheupp app during telehealth follow-up in a population of rheumatoid arthritis patients from a tertiary rheumatology service in south brazil. the main question\[s\] it aims to answer are: • using rheupp app in telemedicine is not inferior to usual care in terms of means obtained by cdai. participants will be stratified by cdai and then randomized 1:1 for intervention or control group. they will be evaluated at study starting, in 3 and 6 months, an extended evaluation after 12 months of recruitment is predicted. researchers will compare intervention and control group to detect differences between usual care and telehealth follow-up and determine if the last is not less effective in our study population of rheumatic patients.

participants with access to digital media will be sent a weblink for accessing the study's electronic questionnaires by electronic message or email, with a maximum interval of one week before or after your in-person consultation, according to the research participant's preference. a tablet will be made available to patients who choose to carry out the survey on the day of their in-person assessment. participants randomized to the intervention group will receive guidance regarding the download or access to the rheupp application, with a period of training and adaptation to the tool, to be carried out by social monitor.

Eligibility criteria:
inclusion criteria: * adult patients (18y or older) * rheumatoid arthritis according to the 2010 eular/acr criteria * access to digital media (electronic messages, e-mail) exclusion criteria: * other rheumatological diseases (except sjögren's syndrome) * inability to understand the instrument in general or assistance from third parties (family member or caregiver) in carrying out the questionnaire at a disadvantage * incomplete information in data collection * patients with changes in their treatment in the last 4 weeks or treatment change plan at recruitment to the study.

Keywords: rheumatoid arthritis telehealth mhealth app
mindfulness-based intervention in copd dyads

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this study evaluates the effectiveness of a mindfulness-based stress reduction intervention (mbsri) on the reduction of stress, anxiety, and depression in people with copd and their family caregivers. the experimental group will receive the mbsri and the control group an informational intervention on stress management.

people affected by chronic obstructive pulmonary disease (copd) and their family caregivers (named dyads) often suffer from psychological distress, because of the physical problems and social isolation imposed by the disease. such psychological distress can influence the ability of patients and caregivers to manage the disease. mindfulness-based interventions have showed benefits in improving the psychological status in various clinical situations. a 8-week mindfulness based-stress reduction intervention will be offered to a group of copd patient-caregiver dyads and its effectiveness will be assessed comparing the effects on a control group to whom an informational intervention on stress reduction will be carried out.

Eligibility criteria:
inclusion criteria: * persons able to read and understand italian. * people affected by copd stage c (gold 3 o 4, and/or 2 or more exacerbations per year or 1 or more hospitalizations for exacerbations and score of copd assessment test-cat \< 10 or mmrc 0-1). * people affected by copd stage d (gold 3 o 4, and/or 2 or more exacerbations per year or 1 or more hospitalizations for exacerbations and score of copd assessment test-cat ≥ 10 or mmrc ≥ 2). exclusion criteria: * persons or dyads not able to guarantee the presence on the mbsr intervention sessions for the four months requested. * persons with diagnosis of anxiety or depression. * persons that have practiced before or actually practice yoga or mindfulness. * persons with cognitive impairment. * persons under continuous oxygen therapy. * persons with diagnosis of cancer or other terminal diseases or any psychiatric problem.

Keywords: dyad caregiver mindfulness copd patient intervention
detection of lada in a hospital in the mexican southeast

Conditions: Latent Autoimmune Diabetes

Summary: patients with latent autoimmune diabetes in adults (lada) show autoantibodies that indicate an autoimmune pathogenesis. glutamic acid decarboxylase autoantibodies (gada) are most prevalent islet autoantibodies in european patients with lada. in this sense, it is considered that it is sufficient to determine gada to identify subjects with lada from patients with t2d for research purposes. therefore, the aim was to investigated the presence of gada in serum of subjects with t2d and its relationship with clinical criteria, metabolic control, drug treatment, and diabetes complications to identify possible patients with lada in a hospital in southeastern mexico is worthwhile. the sample was recruited at the diabetes clinic of the regional hospital of high specialty "dr. gustavo a. rovirosa pérez", in the period from january 2020 to may 2021. the diagnosis was based in accordance with world health organization (who, 1999) criteria. inclusion criteria: 1) patients previously diagnosed with t2d, 2) absence of insulin requirement for at least 6 months after diagnosis, 3) \> 30 and \< 50 years old at diabetes diagnosis, 4) bmi \< 40 kg/m2, 5) subjects who agreed to participate in the study and signed the informed consent before the interview. serum gada and other biochemical concentrations were determined by an enzymatic immunoassay method (human anti-glutamic acid decarboxylase elisa kit; mybiosource).


Eligibility criteria:
inclusion criteria: * patients previously diagnosed with t2d, * absence of insulin requirement for at least 6 months after diagnosis, * \> 30 and \< 50 years old at diabetes diagnosis, * bmi \< 40 kg/m2, * subjects who agreed to participate in the study and signed the informed consent before the interview. exclusion criteria: • patients with other types of diabetes, and subjects who did not agree to participate.

Keywords: lada gada mexican population
serratus posterior superior intercostal plane block, versus erector spinae facial plane blocks

Conditions: Breast Surgery

Summary: mastectomy is currently the most effective treatment for breast cancers in women. postoperative pain management carries a high degree of difficulty, as the breast has complex innervation involving the intercostal (t1-t7), superficial cervical plexus (supraclavicular nerves) and brachial plexus .while severe acute pain is observed in approximately 40% of post-mastectomy patients, moderate-to-severe pain is observed in almost one-third of them .


Eligibility criteria:
inclusion criteria: * age 18 to 65 years * asa classification i and ii exclusion criteria: * age below 18 or above 65 years * asa classification iii or more
study of two dosing regimens of pf-04937319 compared to an approved agent (sitagliptin) in patients with type 2 diabetes

Conditions: Type 2 Diabetes Mellitus

Summary: study b1621019 will assess efficacy and safety of two different dosing regimens of an investigational agent (pf-04937319) compared to an approved drug (sitagliptin) in patients with type 2 diabetes


Eligibility criteria:
inclusion criteria: * patients with type 2 diabetes, on background metformin therapy either alone or with 1 other oral anti-diabetic agent (excluding actos) exclusion criteria: * patients with cardiovascular event within 6-months of screening * patients with diabetic complications * female subjects who are pregnant or planning to become pregnant * subjects with unstable medical conditions (eg, hypertension)

Keywords: phase 1b type 2 diabetes metformin background pf-04937319
evaluation of probiotics and the development of clostridium difficile associated diarrhea in patients receiving antibiotics

Conditions: Development of Clostridium Difficile Associated Diarrhea

Summary: we have designed this study to measure the effect of normal flora supplementation, using available probiotics, on the incidence of clostridium difficile-associated diarrhea in a population of general inpatients who are receiving antibiotics.

general medical-surgical patients in a community hospital who are receiving antibiotics, and who agree to participate, will be given one of two different probiotics, or placebo. data will be gathered during their hospitalization, and at one and three months following hospital discharge. we expect to see a lower incidence of clostridium difficile-associated diarrhea in the probiotic groups when compared to the placebo group. we will also be looking for differences between the effects of the two probiotics, which differ in strain types and number of colony forming units per dose.

Eligibility criteria:
inclusion criteria: any hospitalized patient who is age 19 or older and receiving antibiotics. - exclusion criteria: * feeding tube in place * pregnancy * milk or soy allergy * sensitivity to lactose * immunocompromised defined as: 1. absolute neutrophil count (anc) ≤ 500 cells/mm3 2. hiv 3. cancer patient receiving chemotherapy or radiation therapy 4. immune deficiency 5. post organ transplant participants will be withdrawn from the study if they develop any of the exclusion criteria during the hospitalization. -
self-administered transcranial direct current stimulation for pain in older adults with knee osteoarthritis

Conditions: Osteo Arthritis Knee

Summary: the purpose of this study is to assess the feasibility, acceptability, and efficacy of self-administered transcranial direct current stimulation (tdcs) in older adults with knee osteoarthritis (oa)


Eligibility criteria:
inclusion criteria: * have symptomatic knee oa based on american college of rheumatology clinical criteria * have had knee oa pain in the past 3 months with an average of at least 30 on a 0-100 nrs for pain * can speak and read english * have no plan to change medication regimens for pain throughout the trial exclusion criteria: * prosthetic knee replacement or nonarthroscopic surgery to the affected knee * history of brain surgery, brain tumor, seizure, stroke or intracranial metal implantation * systemic rheumatic disorders, including rheumatoid arthritis, systemic lupus erythematosus, and fibromyalgia * alcohol/substance abuse * current use of sodium channel blockers, calcium channel blockers and nmds receptor antagonists * diminished cognitive function that would interfere with understanding study procedures(i.e., mini-mental status exam score ≤ 23) * pregnancy or lactation * hospitalization within the preceding year for psychiatric illness * no access to a device with internet access that can be used for secure videoconferencing for real-time remote supervision
influence of the covid-19 pandemic on the stress of dental surgeons (covistress - dental surgery)

Conditions: Dental Surgeon

Summary: coronavirus has caused containment of more than half of the world's population and a major and rapid reorganization of clinical and support services. the spread of coronavirus (covid-19) has posed significant challenges for dental surgeons and associates who are at high risk of covid-19 infection due to close face-to-face contact. however, there is currently no data on the influence of this epidemic on the practice and feelings of dental surgeons and associates

this is an observational study by redcap questionnaire® via an internet link, which will be distributed to dental surgeons and associates by any means the self-survey will assess stress, working conditions and changes in practices related to the coronavirus outbreak. this dental surgery questionnaire includes 16 questions

Eligibility criteria:
inclusion criteria: * all dental surgeons and associates volunteers to participate exclusion criteria: * none

Keywords: covid-19 dental surgery stress
use of hydroxyurea and magnesium pidolate for treatment of sickle cell disease

Conditions: Anemia, Sickle Cell

Summary: the purpose of this study is to estimate the mtd of mg pidolate in combination with hu in patients with sickle cell disease who have been on a therapeutic dose (15-30 mg/kg/day) of hu for at least 6 months.

this is a phase i clinical trial evaluating the combination of hydroxyurea and magnesium pidolate for patients with sickle cell disease with either hemoglobin ss disease or hemoglobin s beta thalassemia. hydroxyurea and magnesium pidolate will be tested in pediatric and adolescent patients with sickle cell disease who already have been treated with hydroxyurea for a minimum of six months. magnesium pidolate will be given in combination with hydroxyurea for six months. in successive small groups of patients, the dose of magnesium will be increased in order to eventually determine the maximum tolerated dose (mtd) and dose limiting toxicity (dlt) for magnesium when given in combination with hydroxyurea. the maximum tolerated dose is the highest drug dose that can be given safely to participants. the dose limiting toxicity is determined when drug side effects prevent an increase in dose.

Eligibility criteria:
inclusion criteria: 1. age \> 3 years and \< 15 years at the time of study enrollment 2. diagnosis of hb ss or hb s beta thalassemia 3. hydroxyurea treatment for at least 6 months prior to study entry at dose of 15 - 30 mg/kg/day 4. compliance with taking hu treatment of at least 70 % for 6 months prior to study entry exclusion criteria: 1. red blood cell transfusion within the last 3 months resulting in a level of hb a of 10% or more 2. pregnancy or unwillingness to use effective birth control in sexually active subjects (females who state that they are sexually active) 3. renal dysfunction defined by a serum creatinine greater than 1.5 times the upper limit of normal for age 4. liver dysfunction defined by an alt greater than twice the upper limit of normal for age 5. concomitant usage of an "antisickling" agent other than hydroxyurea 6. current use of mg containing drugs 7. iron deficiency, defined by serum ferritin ≤ 10 ng/ml 8. concomitant chronic illness other than sickle cell anemia

Keywords: hematologic diseases anemia, sickle cell
extracorporeal shockwave lithotripsy, electroconductive and electrohydraulic types

Conditions: Urolithiasis

Summary: to evaluate the efficacy and safety of electroconductive (ec) and electrohydraulic (eh) extracorporeal shock wave lithotripsy (eswl) for the treatment of ureter and kidney stones, this study conducted a randomized controlled trial.


Eligibility criteria:
inclusion criteria: * the analysis included cases of stones in the upper kidney and ureter, with diameters ranging from 5 mm to 15 mm. exclusion criteria: * patients with musculoskeletal deformities, ongoing urinary tract infections requiring prioritized infection treatment, blood clotting disorders, and ureteral obstruction that made stone expulsion difficult were excluded from the study.

Keywords: extracorporeal shockwave lithotripsy urolithiasis radiation exposure
effects of tai chi on multisite pain and brain functions in older adults

Conditions: Chronic Pain

Summary: the main purpose of this randomized controlled trial was to assess the feasibility and acceptability of a 12-week tai chi program for community-dwelling older adults with chronic multisite pain and a history of falling. in addition, the investigators examined the effects of tai chi on pain characteristics, cognition, physical function, gait mobility, levels of pain-related biomarkers, fear of falling and rate of falls in these older adults.

older adults aged ≥65 years with multisite pain who reported falling in the past year or current use of an assistive device were recruited from boston area communities. participants were randomized to either a tai chi (n=28) or a light physical exercise (n=26) program, offered twice weekly for 12 weeks. the primary outcomes were feasibility and acceptability of the 12-week tai chi/light exercise program. secondary outcomes included pain characteristics (pain severity and pain interference), cognition (attention and executive function), physical function (walking speed, strength, and balance), gait mobility (singe-task and dual-task gait), levels of pain-related markers (c-reactive protein, interleukin 6, tumor necrosis factor alpha, and beta endorphin), fear of falling, and rate of falls.

Eligibility criteria:
inclusion criteria: * age of 65 years and older * multisite (2 or more sites) musculoskeletal pain * at least one fall in the past year, or currently on an assistive device * a sedentary lifestyle * be able to walk 20-feet without personal assistance * be able to communicate in english. exclusion criteria: * regular tai chi practice * unstable cardiac disease * stroke * rheumatoid arthritis * degenerative neuromuscular disease * parkinson's disease * terminal disease * dementing illness
validity of 6 minutes stepper test in hypertension

Conditions: Arterial Hypertension; Hypertension

Summary: the six minutes stepper test (6mst) was used assess exercise capacity of individuals having different chronic conditions. in the literature, there are some validation studies analyzing validity of 6mst. in this study, the main aim was to analyse validation of 6mst in hypertensive individuals.

6mst is a space-safe, feasible and sensitive test to assess exercise capacity. in the literature, there are lots of field tests assessing exercise capacity of individuals with chronic status. but common field tests eg 6mwt requires long spaces and it could become an important barrier in clinical settings. hypertension is a common chronic disease and hypertensive individuals are important candidates of cardiac rehabilitation. as an important outcome assesing exercise capacity are very important before and after cardiac rehabilitation. in this study, the main aim was to investigate reliability and validity of 6mst in systemic hypertension.

Eligibility criteria:
inclusion criterias: * being 18 to 65 years, * diagnosed with hypertension and willing to participate the study. exclusion criterias: * having a neurological, cognitive and/or orthopedic disease that affect the measurements, * severe respiratory disease (fev1 \< 35%; fvc \< 50%), * presence of acute infection, * any malignancy, * dementia, * any cardiovascular event in the last 6 months, * uncontrolled hypertension and diabetes * body mass index (bmi) higher than 40 kg/m2

Keywords: stepper test exercise capacity cardiac rehabilitation
physical activity and glycemic control

Conditions: Insulin Resistance

Summary: this study will test the effects of daily physical activity on variations in blood glucose control.


Eligibility criteria:
inclusion criteria: * young, healthy exclusion criteria: * chronic disease
effectiveness of reminiscence therapy versus cognitive stimulation in older adults with cognitive decline

Conditions: Cognitive Decline

Summary: although data suggest that non-pharmacologic therapies such as reminiscence therapy (rt) and cognitive stimulation (cs) can potentially maintain or reverse this trend, cognitive impairment can be a precursor to neurodegenerative processes. this study aimed to assess how an rt and a cs program affected cognition, depressive symptomatology, and quality of life (qol) in older persons with cognitive decline who attended community support institutions in central portugal. for seven weeks, a quasi-experimental study with two arms (rt and cs program) was conducted. the intervention was completed by 76 of the 109 older persons who were first screened (50 in the rt program, 26 in the cs program). in both groups, a pre- and post-intervention analysis revealed statistically significant differences in cognition, particularly in older adults' delayed recall ability.


Eligibility criteria:
inclusion criteria: * ability to give informed consent before study commencement; * ability to participate in group activities for a period between 45 to 60 minutes; * no pronounced impairment of their visual and auditory abilities; * mild to moderate cognitive decline, assessed as a score equal to or below 20 points in the six-item cognitive impairment test (6-cit). exclusion criteria: * unstable clinical condition; * prescribed with cholinesterase inhibitors and/or antipsychotics during the study period.
effectiveness of bracing in preventing scoliosis in children with spinal cord injury

Conditions: Scoliosis

Summary: the purpose of this study is to determine whether full-time high dose prophylactic bracing (23 hours or more per day) is more effective than low dose bracing (12 hours or less per day) in preventing or delaying spinal curve progression in children with scoliosis after spinal cord injury.

this is a randomized control trial to determine the effectiveness of high dose bracing (≥ 23 hours per day) and low dose bracing (≤ 12 hours per day) in skeletally immature children with spinal cord injury. subjects will be randomized into either a prophylactic high dose-bracing group (≥ 23 hours per day) or low dose-bracing group (≤ 12 hours per day). subjects will be stratified by age (younger than age 10 and older than age 10), and curve severity (\< 20 degrees and 20-40 degrees) using a matching random blocks design.

Eligibility criteria:
inclusion criteria: 1. children with c5 to l2 sci. 2. asia impairment levels a, b, or c. 3. age greater than 5 up to one year before end of growth (14 in girls, 16 in boys) 4. a single structural curve \<40 degrees or a double curve \<40 degrees where the largest compensatory curve is \<25 degrees on bending film. 5. children at risk for paralytic scoliosis 6. ability to follow simple instructions. exclusion criteria: 1. curve magnitude \>40 degrees, pressure sores over the trunk. 2. inability to tolerate tlso wears. 3. structural compensatory curves of 25 degrees or greater (double structural curves). 4. severe traumatic brain injury, tbi (8 and below on glasgow coma scale). 5. cognitive impairment 6. less than 6 months from date of injury

Keywords: spinal cord injury tlso brace spine curvature child effectiveness of bracing
10 minutes prewarming and warmed intravenous fluid on core temperature

Conditions: Urologic Diseases

Summary: hypothermia occurs frequently during general anesthesia. this study is to evaluate the efficacy of 10 minutes of prewarming and warmed fluid during urologic surgery.

during general anesthesia, vasodilation distributes body heat and leads to hypothermia. especially during urologic operation (transurethral resection of bladder and prostate), bladder irrigation worsens hypothermia. hence, various methods are used to maintain core temperature during operation. previous studies have demonstrated that prewarming of the patient is effective in maintaining core temperature perioperatively. however, more than 50% of patients who have applied prewarming for more than 30 minutes preoperatively are reported to fall in hypothermia. hence, developing simple and effective method to prevent hypothermia is expected. hence, the investigators planned to examine the effect of active warming (10 minutes of prewarming preoperatively and prewarmed intravenous fluid intraoperatively) on hypothermia in patients undergoing urologic operation under general anesthesia.

Eligibility criteria:
inclusion criteria: * patients undergoing urologic surgery(transurethral resection of bladder, prostate) exclusion criteria: * moderate to severe cardiopulmonary, renal impairment * thyroid disease * any infection sign * abnormal temperature prior to induction of general anesthesia (\ 37.5'c) * refusal to participate in the study * unable to understand the study

Keywords: hypothermia