Kornimate/medical-research-clean huggingface dataset:
anti-inflammatory effects and clinical efficacy of topical thealoz total eye drops in patients with chronic dry eye disease

Conditions: Dry Eye Disease (DED)

Summary: the goal of this prospective, open, monocentric study is to evaluate the clinical efficacy of a new preservative-free combination of trehalose, sodium hyaluronate and naaga in 30 patients with chronic dry eye disease and associated ocular surface inflammation. the main question it aims to answer is: - to assess the improvement of conjunctival hyperemia as well as subjective symptoms in patients with moderate to severe dry eye. participants will be asked to use t2769 on a daily basis.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * normal ophthalmic findings except dry eye disease * chronic dry eye defined as longer than six months since diagnosis * osdi ≥ 22 * conjunctival hyperemia≥ grade 3 (efron scale) * current use of topical lubricants since at least 3 months exclusion criteria: ophthalmic exclusion criteria * best far corrected visual acuity \< 1/10 * severe dry eye associated with: * eyelid malposition * sjogren syndrome * stevens johnson syndrome * corneal dystrophy * ocular neoplasia * filamentous keratitis * corneal neovascularisation * orbital radiotherapy * dry eye related to gvhd * history of any of the following within last 3 months: * systemic treatment of dry eye * systemic treatment of mgd * isotretinoïde, * cyclosporine, * tacrolimus, siromilus, pimecrolimus * punctual plugs * history of any of the following within previous six months: * ocular trauma * ocular infection, ocular allergy * history of any of the following within last 12 months: * inflammatory corneal ulcer * herpetic eye infection * or uveitis * ocular surgery systemic / non ophthalmic exclusion criteria: • known hypersensitivity to any of the components of the medical device under investigation or other study medication specific exclusion criteria for women: * pregnant or breast-feeding woman. * woman of childbearing potential (neither menopausal, nor hysterectomized, nor sterilized) not using effective contraception (i.e. hormonal contraceptives, intra-uterine device, contraceptive implant or condoms) exclusion criteria related to general conditions * inability of patient to understand the investigation procedures and thus inability to give valid, informed consent. * non-compliant patient (e.g. not willing to attend the follow-up visits, way of life interfering with compliance) * participation in another clinical study or clinical investigation at the same time as the present investigation * participation to the present clinical investigation during the exclusion period of another clinical study * patient already included once in this clinical investigation * patient under guardianship
transverses abdominis plane block versus local wound infiltration in total abdominal hysterectomy

Conditions: Pain

Summary: to compare the transverses abdominis plane block outcome versus local wound infiltration for postoperative analgesia in patients undergoing total abdominal hysterectomy.


Eligibility criteria:
inclusion criteria: * age range 18 to 50 years * female * asa i \& ii * undergoing abdominal hysterectomy under general anaesthesia exclusion criteria: * hepatic failure (assessed on clinical signs and symptoms, elevated liver enzymes and ultrasound findings showing loss of normal texture of liver) or renal failure (a gfr of 15 or less) * allergy or contraindication to study drugs on history * drug abuse or addiction * bleeding tendency

Keywords: pain
effectiveness of adacel vaccination in pregnancy at preventing pertussis in infants < 2 months of age in the united states

Conditions: Pertussis (Whooping Cough)

Summary: the purpose of this study is to determine the effectiveness of adacel against pertussis disease in infants \< 2 months when administered during pregnancy following the current advisory committee on immunization practices (acip) recommendations, i.e., from 27 to 36 weeks of gestation, and 14 days or more before delivery.

the original study included cases recorded from 01 january 2011 through 31 december 2014, based on retrospective case-control methodology.

Eligibility criteria:
inclusion criteria: cases were included if they met the following inclusion criteria: * reported pertussis disease in the referenced eip surveillance database * age greater than 2 days and younger than two months of age * resided in the catchment area on date of onset of their cough * born in a hospital in their state of residence * ≥ 37 weeks of gestation at birth * not adopted, in foster care or living in a residential care facility * completed maternal interview * completed infant and maternal information controls were included if they met the following inclusion criteria: * age greater than 2 days and younger than 2 months of age on date of cough onset for the corresponding case infant * resided in the catchment area on date of cough onset for the corresponding case infant * born in a hospital in their state of residence * ≥ 37 weeks of gestation at birth * not adopted, in foster care or living in a residential care facility * maternal interview completed * infant and maternal information complete exclusion criteria: cases were excluded if they met any of the following exclusion criteria: * vaccination status of the mother unknown * infants whose mothers were vaccinated with boostrix or an unknown vaccine brand controls were excluded if they met any of the following exclusion criteria: * vaccination status of the mother unknown * a pertussis diagnosis prior to the cough onset date of the corresponding case infant * controls that were matched to boostrix or an unknown brand cases
evaluation of the efficacy of regional anaesthesia for analgesia after laparoscopic cholecystectomy

Conditions: Postoperative Pain; Laparoscopic Cholecystectomy; Regional Anesthesia

Summary: postoperative pain is important for patient comfort, wound healing and earlier mobilisation. different procedures are used by clinicians for this purpose. intravenous and regional anaesthesia techniques can be used for this purpose in patients undergoing laparoscopic cholecystectomy.

in our study, the investigators aimed to investigate the effectiveness of different methods applied for post-operative pain in patients undergoing laparoscopic cholecystectomy surgery.

Eligibility criteria:
inclusion criteria: * laparoscopic cholecystectomy surgery * patients with asa (american society of anaesthetists) scores i and iii will be included. exclusion criteria: * uncontrolled arterial hypertension * uncontrolled diabetes mellitus, * mental retardation , * antidepressant use * metabolic disorders, * bleeding diathesis * patients with a body mass index above 30.
neoadjuvant furmonertinib and cisplatin/pemetrexed as in egfr mutated stage iiia-iiib resectable nsclc (foresee)

Conditions: Non-small Cell Lung Cancer

Summary: in this open-label, single-arm, phase 2 study, 40 eligible patients with egfr mutated stage iiia-iiib resectable nsclc will be recruited to receive furmonertinib for 9 weeks combined with cisplatin/pemetrexed for 3 cycles (21 d/cycle) as neoadjuvant therapy before radical surgery. radiological and pathological evaluations will be performed before and after the neoadjuvant therapy to assess the efficacy of treatment. adverse events during neoadjuvant therapy, disease and survival status will also be collected in the study.


Eligibility criteria:
inclusion criteria: * with written informed consent before any study procedure * histology or cytology diagnose of non-small cell lung cancer within 60 days * stage iiia/iiib, with resectable lesion(s) by radiology * egfr mutation positive (exon 19 deletions or exon 21 l858r, with or without other egfr mutations) * without prior anti-tumor treatment * with at least one measurable lesions (the longest axis ≥10mm) * ecog performance status 0-1 * using adequate and effective contraception, women should refrain from breastfeeding and have a negative pregnancy test prior to the first administration of the study drug if within during child-bearing age exclusion criteria: * egfr exon 20 insertions positive * mixed with small cell cancer, or other mixed types of lung cancer * any prior anti-tumor treatment * major surgery within 4 weeks before enrolment * women with pregnancy or breastfeeding * use of strong cyp3a4 inhibitors within 7 days or strong cyp3a4 inducers within 21 days before enrolment; use of traditional chinese medicine with anti-tumor effect within 21 days before enrolment * with history of other malignancy except for radical resected tumors without recurrence for 5 years or more * with severe or uncontrolled systemic disease such as uncontrolled hypertention, diabetes mellitus, chronic heart failure, unstable angina, myocardial infarction within 1 year, active hemorrhage, active hbv/hcv/hiv or other infections requiring infusion treatment * severe gastrointestinal diseases which may affect the intake and absorption of study drug * prolongation of ecg qtc or with relative risk factors * history of interstitial lung disease or with relative risk factors * inadequate organ function of hematology, liver and kidney * allergic to study drugs or any component * poor adherence or other situation judged by investigator * patients who had participated other clinical studies of tumors

Keywords: furmonertinib ast2818
led treatment to improve cognition and promote recovery in tbi

Conditions: Traumatic Brain Injury; Posttraumatic Stress Disorder

Summary: this study investigates the efficacy of a novel neuromodulation treatment, light emitting diodes (led), on cognition, neuropsychiatric status and quality of life in individuals with traumatic brain injury (tbi).

the most common traumatic brain injury (tbi)-associated problems are cognitive deficits and neuropsychiatric problems, such as sleep disturbance and ptsd. this study evaluates a novel neuromodulation intervention, light emitting diodes (led), for treatment of patients with tbi. led is a noninvasive, non-thermal, painless treatment, which does not involve any needles or any form of surgery. led treatment improves cellular activity of the brain tissue that has been damaged by tbi. half of the study participants will receive active led treatment, and a control group will receive sham led. this study takes place in boston, massachusetts: at the va boston healthcare system.

Eligibility criteria:
inclusion criteria: inclusion criteria: * oef/oif active-duty personnel or veterans with history of tbi or blast-exposure * meets criteria for mild tbi * loc of 30 min or less * age: 21-55 * primary language is english exclusion criteria: * evidence of penetrating head injury * history of previous neurological diagnosis * history of previous psychotic disorder prior to tbi * hearing or vision impairment

Keywords: traumatic brain injury light emitting diodes cognition neuromodulation ptsd neurorehabilitation veterans sleep
ventral hernia prevention after liver transplantation

Conditions: Ventral Hernia; Liver Transplantation

Summary: this study aims to evaluate if the risk of developing ventral hernia after liver transplantation can be reduced through the prophylactic implantation of a synthetic, fully resorbable mesh "phasix" in the course of liver transplantation. patients will be randomized in a 1:1 ratio to receive either phasix mesh or standard surgery without the use of phasix. ultra-sound examinations of the wound area will be performed 14 days, 3, 6 and 12 months after liver transplantation. furthermore, presence of infections, seroma, pain and other problems in the wound area will be assessed.

ventral hernia is a frequently occurring complication following liver transplantation, with a reported risk in the literature ranging from 5% to 25%. this study aims to evaluate if the risk of developing ventral hernia after liver transplantation can be reduced through the prophylactic implantation of a synthetic mesh "phasix" in the course of liver transplantation. phasix™ mesh is a fully resorbable mesh implant prepared from poly-4-hydroxybutyrate (p4hb). absorption of the mesh material occurs within 12 to 18 months. patients will be randomized in a 1:1 ratio to receive either phasix mesh in the course of liver transplantation or standard surgery without the use of phasix. ultra-sound examinations of the wound area will be performed 14 days, 3, 6 and 12 months after liver transplantation. furthermore, presence of infections, seroma, pain and other problems in the wound area will be assessed.

Eligibility criteria:
inclusion criteria: * age \>18 years * first transplantation * signed informed consent exclusion criteria: * combined transplantation * revisions after liver transplantation * patients who already received laparotomy or transverse upper laparotomy (longer than 15 cm) * preexisting abdominal wall hernia except umbilical hernia after liver transplantation * pregnant/lactating women * known allergies to tetracycline hydrochloride and kanamycin sulfate
clinical trial comparing safety and pharmacokinetics of standard antibiotic therapy, plus aurexis® or placebo, for treatment of staphylococcus aureus bacteremia (sab)

Conditions: Staphylococcus Aureus Bacteremia

Summary: hospitalized patients at least 18 years of age, with staphylococcus aureus bacteremia (sab) will be enrolled into the study and receive one dose of aurexis® intravenously on study day 1, and will be followed until study day 57. aurexis is a humanized monoclonal antibody that is designed to combat staphylococcus aureus. the purpose of this study is to assess the safety and pharmacokinetics of standard antibiotic therapy, plus aurexis or placebo for treatment of (sab). additionally, certain tests and measurements will be conducted to preliminarily determine if aurexis demonstrates any benefit to these patients.


Eligibility criteria:
inclusion criteria: * male or female, age ≥ 18 years old * informed consent obtained from subject or legal guardian * willing to practice reliable birth control measures during the study period * diagnosis of sab, as evidenced by clinical symptoms and one positive blood culture obtained ≤ 72 hours prior to initiation of study drug infusion exclusion criteria: * pregnant or nursing females * polymicrobial bacteremia * diagnosis of septic shock (refer to appendix b) * neutropenia (absolute neutrophil count \< 500/mm³) * undergoing any type of dialysis or expected to start dialysis within 30 days * moribund clinical condition with a high likelihood of death within 72 hours of randomization * received an investigational drug within 30 days of study entry * considered unlikely to comply with the study procedures or to return for scheduled post-treatment evaluations

Keywords: staphylococcus aureus bacteremia sepsis
single-arm study of photodynamic laser therapy using foscan for non-curatively-resectable bile duct carcinoma

Conditions: Non-curative Resectable Bile Duct Carcinoma

Summary: the purpose of this study is to assess efficacy and safety of foscan (temoporfin) photodynamic therapy in the treatment of locally advanced perihilar bile duct carcinoma without distant metastases.


Eligibility criteria:
inclusion criteria: * bile duct carcinoma proven by histology in advanced or non-operable stage or tumor extension: 1. bismuth type iii or iv ( not resectable with r0-margins ) 2. bismuth type i or ii, if resective surgery is contraindicated for old age or poor surgical risk of patient * sufficient general condition to undergo pdt (karnofsky status \> 30%) * age \> 19 years * access to common bile duct (either via endoscopy after sphincterotomy or percutaneously after transhepatic drainage), * informed written consent exclusion criteria: * porphyria or other diseases exacerbated by light * known intolerance or allergies to porphyrin derivatives * a planned surgical procedure within the next 30 days * coexisting ophthalmic disease likely to require slit lamp examination within the next 30 days * impaired kidney or liver function (creatinine \> 2.5x elevated, inr \> 2.2 on vitamin k), * leukopenia ( wbc \< 2000/cmm ) or thrombopenia ( \< 50000/cmm ), * cytotoxic chemotherapy within the past 4 weeks. * pregnancy ( and safe contraception for 6 months after pdt ) * accompanying/complicating disease with very poor prognosis (expected survival \< 6 weeks), * proven advanced peritoneal carcinomatosis ( pet scan imaging, ascites positive for tumor cells)
increasing hiv testing in urban emergency departments via mobile technology

Conditions: HIV Testing

Summary: because people with undiagnosed hiv will not receive treatment and may unknowingly infect others, the investigators propose a mobile computer-based video intervention to increase hiv test rates in high volume urban hospital emergency departments (eds). eds offer important points of contact for many of those at greatest risk for hiv. unfortunately, when ed patients are offered routine hiv testing, most decline. our proposed intervention builds upon initial findings from a trial our research team conducted with patients who declined hiv testing. the intervention, grounded in the information-motivation and behavioral skills model (imb), showed an onscreen physician explaining the importance of hiv testing (to build knowledge and motivation) and modeling a rapid hiv test (to increase motivation and behavioral skill). this brief intervention had a potent effect: a third accepted hiv testing post-intervention. while this preliminary study is highly encouraging, it revealed a number of other critical research questions. first, it remains unclear what intervention component most strongly contributed to patients' decisions to test: the video content or the offer of an hiv test by a computer rather than a person. second, consistent with the literature, participants indicated a community member disclosing positive hiv status onscreen would increase the proportion of patients who test. third, results suggest there is individual variation in the extent to which behavior is more strongly influenced by onscreen community members or experts (e.g. physicians). therefore, the goal of the present study, guided by the imb model, is to determine how the investigators can refine mobile computer-based interventions to maximize hiv testing rates among patients who initially decline to test in the ed. at the end of the computerized intervention, onscreen text will ask patients if they would agree to an hiv test. those who agree will be tested by ed staff. the study's endpoint will be post-intervention hiv test rates. the investigators' study will inform scalable interventions for underserved populations nationwide.


Eligibility criteria:
inclusion criteria: * age 18 or over * capable of providing informed consent * reads english * declined hiv test offered by hospital staf at triage exclusion criteria: * intoxicated * a prisoner * known to be hiv positive * presenting to the hospital for a psychiatric problem
augmentation of exposure using positive mental rehearsal in individuals with increased social anxiety

Conditions: Social Anxiety; Social Phobia

Summary: efficacy of an optimized exposure therapy training is investigated in individuals with heightened social anxiety. participants will undergo a one-session standardized exposure training, followed by either standard or positive mental rehearsal of the exposure experience. the efficacy is measured by symptom improvement according to subjective ratings one week later.

exposure therapy is widely recognized as the gold-standard treatment for anxiety disorders, but its clinically significant response rates remain around 50%. thus, innovative approaches are needed to improve the efficacy of exposure therapy. one strategy is the mental rehearsal of exposure treatment as a way of supporting the retrieval and consolidation of the exposure memory, which has been demonstrated to be an effective supplement to exposure therapy in a recent study. new conceptualizations also emphasize the role of reward processing and its importance in extinction learning. several strategies have been proposed to target these reward processes to improve the outcomes of exposure therapy. the present study will examine the use of a positive-focused rehearsal strategy. participants in the optimized exposure group will engage in an imaginal recounting task focusing on the positive aspects (i.e. emotions, thoughts, behavior) of the exposure. rehearsal of the positive aspects may increase positive affect, with positive mood thought to be associated with deeper mental rehearsal of stored information. therefore, the efficacy of using positive mental rehearsal (i.e., imaginal recounting) post-exposure will be investigated, with the use of standard mental rehearsal as an active control group. participants will be asked to repeat the rehearsal experience at home at two-day intervals. post-treatment assessment will be conducted one week later. the study will be conducted on healthy participants with an elevated level of social anxiety. the aim of this randomized controlled trial in healthy individuals with increased social anxiety is to investigate whether optimized exposure training (exposure + positive mental rehearsal) is more effective in reducing fear of social interaction compared to an active control group (exposure + mental rehearsal).

Eligibility criteria:
inclusion criteria: * elevated score on social interactions anxiety scale (sias) \> 26 exclusion criteria: * current psychotherapeutic/psychiatric treatment * plans to start psychotherapeutic/psychiatric treatment in upcoming weeks * current suicidal intent * severe cardiovascular, respiratory or neurological diseases
comparison of verbal rating scale and numerical rating scale in post anesthesia care unit

Conditions: Pain Measurement; Acute Pain; Postoperative Pain

Summary: in the postanesthetic care unit(pacu), patients who are recovering from anesthesia are not easy to communicate with. accordingly, accurate evaluation of acute surgical pain is difficult for pacu patients in spite of severe postoperative pain. therefore, pain evaluation is clinically important and challenging in pacu. the pain evaluation tool should be simple and easy to understand for accurate assessment. among the most commonly used pain assessment methods are numerical rating scale(nrs), visual analogue scale(vas) and verbal rating scale(vrs). these three methods have proved valid for clinical situations in many studies. vrs appears to be easier to understand than the other two methods for patients in pacu. the purpose of this study is to compare nrs and vrs in pacu patients.


Eligibility criteria:
inclusion criteria: * adult patients who underwent general anesthesia * the american society of anesthesiologists(asa) physical status classification system : class 1, 2, 3 exclusion criteria: * the american society of anesthesiologists(asa) physical status classification system : class 4, 5