Kornimate/medical-research-clean huggingface dataset:
bad berka heart rhythm registry of patients with or at risk of arrhythmias treated at heart center bad berka

Conditions: Cardiac Arrhythmias

Summary: the bad berka heart rhythm registry (2b2r) is a prospective, single-center observational cohort designed to systematically collect and analyze data of patients undergoing cardiac arrhythmia therapy as well as implantation of cardiac electronic devices (cieds) at the heart center bad berka. the register aims to evaluate procedural safety, acute and long-term efficacy, and clinical outcomes across a broad spectrum of arrhythmias and interventional strategies, including novel technologies such as pulsed field ablation (pfa) and conduction system pacing. the registry is intended to generate real-world evidence to support clinical decision-making, identify predictors of outcomes, and contribute to quality assurance and innovation in the field of cardiac electrophysiology.

the field of cardiac electrophysiology continues to evolve rapidly, with new tools and techniques improving both arrhythmia diagnosis and therapy. while randomized controlled trials provide critical insights, real-world data from clinical practice are essential to evaluate safety, efficacy, and long-term outcomes across diverse patient populations and treatment modalities. the 2b2r registry aims to bridge this gap by collecting comprehensive clinical data of patients referred for cardiac arrhythmia treatment including drug therapy, electrophysiological studies, catheter ablation (e.g. atrial fibrillation, atrial flutter, atrial and av-node dependent supraventricular tachycardia, premature ventricular contractions, and ventricular tachycardia), interventional stroke-prevention, as well as device implantation at the heart center bad berka. data will be prospectively collected, procedural parameters, complication rates, acute success, follow-up outcomes, imaging, device therapy, and patient-reported outcomes will be assessed. substudies focused on specific arrhythmias or technologies (e.g., pulsed field ablation, high-density mapping, or device therapy such as conduction system pacing) will be embedded within the registry. the data will be analyzed to: - evaluate clinical effectiveness and safety of interventional ep procedures - assess predictors of arrhythmia recurrence or procedural complications - compare technologies and procedural strategies - monitor quality metrics and inform continuous process improvement participation in the registry does not influence clinical management which remains at the discretion of the treating physicians. the registry complies with all applicable data protection and ethical standards.

Eligibility criteria:
inclusion criteria: * age ≥18 years * at risk of or with documented cardiac arrhythmia undergoing medical or interventional therapy at the heart center bad berka * informed consent obtained exclusion criteria: * inability or unwillingness to provide informed consent * participation in another interventional trial that precludes registry inclusion

Keywords: arrhythmia
comparison between provisional versus routine kissing balloon technique after main vessel crossover stenting for bifurcated lesions.

Conditions: Coronary Artery Disease

Summary: in the setting of single stent strategy for treatment of bifurcation, we investigate to compare simple strategy as "provisional final kissing balloon technique(fkbt)" to complex one as "routine fkbt", focusing on actual myocardial ischemia assessed by scintigraphy in 7-month and to examine optimal endpoint of side branch ostium.

final kissing balloon technique (fkbt) is effective and accepted technique for the treatment of bifurcation. however, in complex lesion or anatomy, much procedure-time and contrast media are needed to accomplish this technique. recent ffr study for jailed side branch (sb) demonstrated that angiographic severe stenosis at sb ostium includes "pseudo-stenosis" and stent-deployment jailing sb without fkbt has comparable impact on clinical outcome with fkbt strategy. considering simple technique for bifurcation, we sought to investigate to compare "provisional fkbt" with "routine fkbt", focusing on actual myocardial ischemia assessed by scintigraphy in 7 month and to examine optimal endpoint of sb ostium.

Eligibility criteria:
inclusion criteria: (patient) patient who has angina or documented ischemia, patients who are eligible for drug eluting stent, age \>=18, patient who received informed consent, patient who can receive dipyridamole-stress-technetium scintigraphy. (lesion) non-left main bifurcation except for medina class (0,0,1), de-novo lesion, vessel diameter in visual (main vessel\>2.5mm, side branch \>2.0mm), sb lesion length \<5mm in visual estimate, mb lesion length \< 46mm in visual, timi 3 in main vessel as well as side branch, exclusion criteria: (patient) patients who is pregnant, patient contraindicated for antiplatelet therapy, patients whose ejection fraction is less than 30%, patients who has renal dysfunction, creatinine \>=2.3, patients who has live dysfunction, patients who cannot agree with informed consent, patient whose life expectancy is less than 1 year, patients contraindicated for dipyridamole-stress-technetium scintigraphy. (lesion) target site of acute myocardial infarction, left main disease, in-stent restenosis lesion, bypass graft, chronic total occlusion, main vessel reference diameter \>4.5mm, bifurcation lesion that needs intended 2 stent strategy, highly tortus and calcified lesion,
can3t - canadian tavi triage tool

Conditions: Aortic Stenosis

Summary: the goal of this trial is to see if a tool that may reduce wait times will reduce bad outcomes in participants on the tavi waitlist. the main questions it aims to answer are: * how many deaths, hospitalizations, or urgent tavi procedures take place while participants wait * days alive and out of hospital at 30 days and 12 weeks, total health care costs, and wait times researchers will compare usual wait times to see if the tool reduces death, hospitalizations, and urgent procedures.


Eligibility criteria:
inclusion criteria: * all patients referred for tavi who are 18 years or older at one of 11 tavi hospitals exclusion criteria: * any inpatient referrals who have an urgent inpatient tavi on the same admission * any referral during the 1-month transition period

Keywords: aortic stenosis tavi trans-catheter aortic valve implantation cardiovascular disease surgical aortic valve replacement
evaluation of morphotep with the fdg among patients in severe sepsis of unspecified etiology

Conditions: Severe Sepsis

Summary: the objective of this pilot study is to estimate a procedure where the biological samples routinely obtained at the site of suspected infection could be guided by the early realization of a tep with fdg coupled to scanner x, in patients hospitalized in icu for severe sepsis of unspecified etiology.

severe sepsis constitutes the leading cause of mortality in icu, in particular because a microbial documentation is lacking in about half of the cases. tomography by emission of positons, which uses the property of activated macrophages and leucocytes to collect 18f-fluorodeoxyglucose may prove useful to identify the site(s) of infection and then guide sampling. thirty patients will be included over 12 months. within 24 hours after admission, patients presented with a severe sepsis of still unknown etiology will benefit from the realization of a morphotep, including an examination mtoe with the fdg, associated with a conventional scanner x. suspected infected sites will then be the subject of sampling when possible. these samples will be send for microbial culture, histology and trem-1 expression (membrane-bound and soluble form) when appropriate. the main judgement criteria will be the percentage of the mtoe exams proved to be useful for diagnosis and/or associated with therapeutic modifications. this pilot study will make it possible to evaluate the interest of the early realization of a tep/scanner x examination among severe sepsis patients of unknown origin.

Eligibility criteria:
inclusion criteria: * patient hospitalized with severe sepsis * absence of infected site clearly identified after 48 hours of a conventional diagnosis assessment or suspicion of one or more additional sites * indication of scanner x with injection * informed consent obtained exclusion criteria: * age over 80 * immunocompromised status * surgical intervention within the previous month * hemodynamic instability (defined by the use of more than 0.5µg/kg/min vasopressors) * severe hypoxia (defined by a pao2/fio2 ratio lower than 150) * pregnancy * patient already included in another protocol * anaphylaxis to flucis

Keywords: medical icu severe sepsis
the influence of the diaphragm muscle and pain perception on lower limb neuromuscular control in sports practice.

Conditions: Diaphragm; Relaxation

Summary: core stability is maintained mainly by muscle function of abdominal and lumbar region, including the diaphragm muscle. it is known that exists a connection between trunk's muscle activity and the movement of lower limb and lower limb and low back injuries are related to core alterations. thus, a randomized clinical trial is planned to analyze the effectiveness of an exercises and manual therapy of the diaphragm and ribs program designed, aiming to analyze the correlation between rib cage mobility and lower limb neuromuscular control in young healthy subjects.

the aim of the study consists on analysing the correlation between rib cabe mobility and neuromuscular control parameters of lower limb, as well as pain perception in young healthy adults sports players. a clinical practice protocol consisting on breathing exercises and manual therapy of the muscle diaphragm and the ribs will be applied twice a week during eight weeks. as a result, could be an increasement of the neuromuscular control parameters, described with the outcome measures of rib cage mobility, lower limb power and stability, and pain perception. if the results stablish correlation between the rib cage mobility and neuromuscular control parameters of lower limb, could be helpful in healthcare and sports science field in order to take in account the diaphragm biomechanics when treating lower limb injuries and facing its prevention.

Eligibility criteria:
inclusion criteria: * physical activity practice: at least 150-300min of moderate activity or 75-100min of intense aerobic activity, twice a week. * physical activity or sports practice involve mostly lower limb muscles activation. * core stability exercises least twice a week. includes at least 3 of the 6 exercises listed: bridge exercises, standard plank, lateral plank, superman exercise, mountain climber and plank variations. exclusion criteria: * musculoskeletal injury currently or in the past 6 months. * abdominal or thoracic surgery. * nervous system disease. * hiatal hernia or visceral disease. * pelvic floor alterations or disease. * breathing restrictions: disease or infection, asthma, anxiety or other non controlled alterations. * treatment of the diaphragm muscle the past 6 months.

Keywords: core stability diaphragm muscle rib cage breathing biomechanics
ultrasound evaluation of cesarean scar after uterotomy closure with barbed and conventional sutures

Conditions: Cesarean Section Scar

Summary: the aim of this randomized control trial is to compare the residual myometrial thickness and the depth of cesarean section scar defect after uterine incision closure with barbed or conventional sutures.

the aim of this randomized control trial is to compare the residual myometrial thickness and the depth of cesarean section scar defect after uterine incision closure with barbed or conventional sutures. primigravida patients undergoing transverse lower segment cesarean section will be included in the study.cesarean section incision will be closed with double layers of continuous barbed or conventional sutures. ultrasound examination will be performed 6 months after the operation to measure the residual myometrial thickness and the scar depth.

Eligibility criteria:
inclusion criteria: * primigravida patients undergoing transverse lower segment cesarean section exclusion criteria: * previous laparotomies * postoperative fever * patients with preterm pregnancies or in labor

Keywords: cesarean section scar, barbed suture, conventional suture
different types of suture for sacral colpopexy

Conditions: Pelvic Organ Prolapse

Summary: this randomized controlled study is designed to test absorbable suture compared to non absorbable suture in laparoscopic sacral colpopexy in terms of anatomical correction of the prolapse, post-operative and long term morbidity, rate of recurrence, subjective satisfaction of the patient and rate of mesh erosion.


Eligibility criteria:
inclusion criteria: * patients who required surgical treatment for symptomatic pelvic organ prolapse stage ≥ 2 with or without stress urinary incontinence exclusion criteria: * age \> 75 years * severe cardiovascular or respiratory disease * pregnancy
does tailored education in asthma care help improve patient satisfaction, adherence, and quality of life (teach) trial

Conditions: Asthma

Summary: the primary purpose of this study is to assess whether tailored patient education for patients on symbicort® turbuhaler® therapy improves patient satisfaction, adherence and quality of life.


Eligibility criteria:
inclusion criteria: * patients with the diagnosis of asthma. * patients with asthma, where the use of symbicort® turbuhaler® is indicated and would have been prescribed by the investigator as part of usual care. * patient who have public or private insurance coverage for symbicort® turbuhaler® or are willing to pay for this medication for the duration of the trial. exclusion criteria: * patients who have been treated wth symbicort® turbuhaler® in the preceding 3 months. * a history of smoking \[i.e., 10 pack-years where one pack-year equals one pack (20 cigarettes) per day for one year, or equivalent\].

Keywords: asthma education satisfaction adherence quality of life piko meter cluster symbicort® turbuhaler®
effects of high-concentration topical capsaicin on histaminergic and non-histaminergic itch

Conditions: Pruritus

Summary: the purpose of this project is to investigate the effect of capsaicin-induced neurogenic inflammation with three different intensities on itch subsequently induced by histamine and cowhage. the hypothesis is that capsaicin-induced pre-established neurogenic inflammation significantly increases susceptibility to itch provocations with cowhage and histamine.


Eligibility criteria:
inclusion criteria: * healthy men and women * 18-60 years * caucasian descent * speak and understand english exclusion criteria: * pregnancy or lactation * drug addiction defined as any use of cannabis, opioids or other drugs * previous or current neurologic, musculoskeletal or mental illnesses * lack of ability to cooperate * current use of medications that may affect the trial * skin diseases * consumption of alcohol or painkillers 24 hours before the study days and between these * moles or tattoos in the area to be irradiated * exposure of the irradiated area to uv radiation (e.g., sun) 48 hours before the study days and between these * acute or chronic pain * participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)
technical evaluation of jewelpump in type 1 diabetic patients treated with extern insulin pump

Conditions: Type1diabetes

Summary: the main objective of the study is to verify the reliability of the solutes volumes issued by the debiotech jewelpumptm controlled by its remote. three clinical sites are participating in this study: * chsf, service of endocrinology and diabetology, corbeil-essonnes (91): dr. guillaume charpentier, dr. sylvia franc * grenoble university hospital, department of endocrinology, diabetes diseases, nutrition, grenoble (38): pr pierre-yves benhamou * chu jean minjoz, department of endocrinology and diabetology, besancon (25): professor alfred penfornis, dr. annie clergeot the study will be conducted in 20 patients with type 1 diabetes treated by external insulin pump. patients will be informed of the study during a screening visit. after signing the informed consent, they will return to the center where they will wear a jewelpumptm containing saline water, they will use their pumps in parallel. the investigator or nurse education will form the operation of the jewelpumptm and they will be instructed to replicate the same settings between their usual and jewelpumptm pump. the patient will be asked to complete visual analog scales of satisfaction with their usual treatment and the various elements of the devices (usual pump, and jewelpumptm) have been weighed using a precision balance to have a form of a base for comparison. patients will leave home for a period of about three days, but they will have to come back every days to the center. they will be asked to collect all events arising (programming problems to deliver a bolus, hardware failure ...) in a booklet. at the end of study visit, patients will return to the center where the volumes will be assessed by the perfused weighed the various components and devices where they will complete the visual analog scales of satisfaction at endpoint.


Eligibility criteria:
inclusion criteria: * type 1 diabetic patient treated by external insulin pump for at least 6 months * patient with a hba1c \< 9% * patient age over 18 years of age * patient having signed the consent and informed form * patient affiliated with the social security exclusion criteria: * patients with diabetes type 2 * patient pregnant or likely to be * all serious pathologies that can interfere with the study * incompatible psychiatric pathologies with the study
effects of digital vaginal examination during labor on pain and anxiety levels

Conditions: Pregnancy; Obstetric Labor

Summary: digital vaginal examination is the most common method for assessing progress of labor and delivery. considering it is the most common intervention women receive during course of labor, evidence for psychological effects of digital vaginal examination on women is surprisingly sparse. reducing the number of vaginal examination during labor has been proposed by many authors as benefit of more vaginal examination is unclear. however this is unlikely to happen until more research on the topic demonstrates clear detrimental effects of vaginal examination. our study is aimed at investigating association of vaginal examination with psychological distress of women during labor. anxiety during labor is associated with longer labor duration, increased perception of pain, problems with newborn attachment, and increased rates of postpartum depression and post-traumatic stress disorder. in this study, women were assigned to either digital vaginal examination or transperineal ultrasound assessment groups were compared to each other in a randomised controlled setting.


Eligibility criteria:
inclusion criteria: * multiparous women * spontaneous active labor * cephalic presentation exclusion criteria: * women with known psychiatric disorders * labor induction * advanced labor during admission (dilatation greater than 7cm) * presence of a prenatally diagnosed anomaly in fetus * admission to neonatal intensive care unit after delivery * delayed hospital discharge due to excessive weight loss of neonate

Keywords: labor, vaginal examination, transperineal ultrasound, pain, anxiety
selective prevention of anxiety disorders in children: a parent training intervention for anxious parents

Conditions: Anxiety Disorders

Summary: anxiety is the most frequent psychiatric problem in children. untreated anxiety often has a chronic course, or may be a recurring condition. anxiety in children predicts a variety of psychiatric disorders later in life, and involves problems regarding school performance and social relations. the literature provides a number of factors, which are suggested to increase the risk of developing an anxiety disorder. in particular, it has been shown that children of parents with anxiety disorders are at much greater risk of developing an anxiety disorder. several studies have found a correlation between anxiety in the child, and parent behavior characterized by criticism, control and overprotectiveness. the present study aim to preliminary evaluate whether a eight week parent training intervention can reduce the incidence of anxiety disorders in children and to evaluate the feasibility of the parent training. three central factors has been the basis in developing the parent training, all of which are considered to be involved in the development and maintenance of anxiety disorders in children (1) criticism and rejection, (2) control and overprotectiveness, and (3) parental modeling and reinforcement of anxiety. the goal of the parent training is therefore (1) to increase warmth and acceptance, (2) to increase autonomy for the child, and (3) modeling and reinforcement of brave behavior. the investigators intend to include 60 anxious parents in the study, who will be randomly allocated to either group parent training, internet delivered parent training, or wait-list condition. the inclusion criteria are as follows: the parent states that he/she experiences anxiety or worry, the parents' child is 6-12 years old, and do not fulfill criteria for an anxiety disorder or major depressive disorder, the parent possesses everyday access to the internet, and there is no presence of very aggravated family situations, such as parent substance abuse or severe depression, or domestic violence.


Eligibility criteria:
inclusion criteria: * the parent states that he/she experiences anxiety or worry, * the parents' child is 6-12 years old, and do not fulfill criteria for an anxiety disorder or major depressive disorder * the parent possesses everyday access to the internet exclusion criteria: * presence of very aggravated family situations, such as parent substance abuse or severe depression, or domestic violence.
effects of pioglitazone in congenital adrenal hyperplasia

Conditions: Congenital Adrenal Hyperplasia

Summary: congenital adrenal hyperplasia, an autosomal recessive condition, is mainly caused by mutations in the gene 21-hydroxylase and is treated with glucocorticoids in a slightly supraphysiological dose. adult patients seem to be characterized by insulin resistance, which may be caused by the glucocorticoids and/or the accompanying obesity. the hypothesis of this study is that pioglitazone can improve insulin sensitivity and correlated cardiovascular risk factors in this specific group of patients. this will be tested in a randomized, placebo-controlled, cross-over trial; insulin sensitivity will be quantified by euglycemic hyperinsulinemic clamp studies.


Eligibility criteria:
inclusion criteria: * biochemical and genetically proven congenital adrenal hyperplasia * stable corticosteroid replacement for 3 months exclusion criteria: * age \< 18 years * inability to give informed consent * significant cardiovascular disease, defined as myocardial infarction or stroke, six months preceding the study * significant renal disease, gfr \< 30 ml/min * significant liver disease, defined as more than 3 times upper limit of normal values of alanine aminotransferase (alt) and aspartate aminotransferase (ast) * pregnancy * mental disease