Kornimate/medical-research-clean huggingface dataset:
diagnostic validation of wearable ecg monitoring patch, atp-c120

Conditions: Atrial Fibrillation New Onset

Summary: a new wearable patch-type device, atp-c120 (atsens, seongnam, korea) is a novel, single-lead ecg monitoring device and can continuously monitor the ecg signal for upto 11 days. this study is designed to experiment its diagnostic capability of new-onset atrial fibrillation in high risk patients. several studies reported that validated cha2ds2-vasc score has high performance in predicting new-onset atrial fibrillation and there are over 10 percent of new-onset atrial fibrillation in patients whose calculated cha2ds2-vasc scores are ≥ 2. thus, through this study, the investigators sought to evaluate the validation of early detection of new-onset atrial fibrillation by atp-c120.

the prevention of stroke associated with atrial fibrillation is a leading global health concern. this devastating event is largely preventable with anticoagulant therapy. therefore, the early detection and accurate diagnosis of arrhythmia are crucial for prevention of adverse outcome. however, because atrial fibrillation is often intermittent and mostly asymptomatic, it is difficult to capture an excise event. conventional electrocardiogram (ecg) monitoring devices including multi-lead portable ecg monitoring device, event-detection monitoring device, and implantable ecg monitoring device are useful for early detection of atrial fibrillation, but these devices have various drawbacks such as requirement of multiple out-patient visits and need of invasive implantation of devices. a new wearable patch-type device, atp-c120 (atsens, seongnam, korea) is a novel, single-lead ecg monitoring device and can continuously monitor the ecg signal for upto 11 days. it has recently demonstrated its diagnostic capability and safety compared to the conventional ecg monitoring systems . yet, it has not widely used in real-world. so, this study is designed to experiment its diagnostic capability of new-onset atrial fibrillation in high risk patients. several studies reported that validated cha2ds2-vasc score has high performance in predicting new-onset atrial fibrillation and there are over 10 percent of new-onset atrial fibrillation in patients whose calculated cha2ds2-vasc scores are ≥ 2. thus, through this study, the investigators sought to evaluate the validation of early detection of new-onset atrial fibrillation by atp-c120.

Eligibility criteria:
inclusion criteria: 1. patients who provide written and informed consent to participate 2. patients whose calculated cha2ds2-vasc score is ≥ 2 exclusion criteria: 1. subjects previously diagnosed with atrial fibrillation 2. subjects implanted pacemaker, cardioverter-defibrillator, or any electrical devices 3. subjects had skin problems such as allergic contact dermatitis 4. female patients who are pregnant, or lactating status.

Keywords: arrhythmia atrial fibrillation wearable electronic device
functional neuroimaging in parkinson's disease

Conditions: Parkinson Disease; Healthy Aging

Summary: the study uses magnetic resonance imaging (mri) to better understand changes in the brain underlying motor symptoms affecting upper and lower limbs in parkinson's disease.

there is a tremendous need to improve the understanding of the pathophysiology underlying motor symptoms in parkinson's disease in order to optimize existing treatment options/develop new therapies. this study seeks to further the understanding of impaired movement in parkinson's disease by examining brain changes and how these relate to changes in motor behavior. the study uses magnetic resonance imaging (mri), a noninvasive imaging technique that does not include x-rays. mri will assess brain activity in response to simple and coordinated movements of the upper and lower limbs that participants have to perform inside the mri scanner. motor and cognitive function outside the scanner using various clinical and behavioral tests will also be assessed. the study includes 1 visit to the university of delaware.

Eligibility criteria:
inclusion criteria: * a clinical diagnosis of parkinson's disease * no neurological disorders if interested in participating as a control participant * must be capable of providing informed consent * must be eligible to receive a brain mri exclusion criteria: * a secondary movement disorder diagnosis in addition to parkinson's disease * dementia * medical conditions that may make one ineligible for receiving a brain mri * inability to provide informed consent * control/healthy group: neurological disorders * control/healthy group: cannot walk without an assistive device/mobility problems
tendon transfer for irreversible radial nerve palsy, does it help?retrospective cohort from level-1 trauma center.

Conditions: Radial Palsy

Summary: radial nerve palsy is associated with serious disability jeopardizing the grasp and power grip accountable to the loss of thumb and fingers extension and loss of active wrist extension respectively. there are three aims in the treatment of radial nerve palsy which comprise the restoration of thumb extension and abduction, finger extension and restoration of wrist extension. in this study we measured the functional outcome after tendon transfer for radial nerve palsy aimed to restore the wrist extension, finger extension and thumb extension/abduction. investigators' objective was to assess the functional outcome after tendon transfer surgery for radial nerve palsy.

radial nerve palsy is associated with serious disability jeopardizing the grasp and power grip accountable to the loss of thumb and fingers extension and loss of active wrist extension respectively. there are three aims in the treatment of radial nerve palsy which comprise the restoration of thumb extension and abduction, finger extension and restoration of wrist extension. in this study we measured the functional outcome after tendon transfer for radial nerve palsy aimed to restore the wrist extension, finger extension and thumb extension/abduction. investigators' objective was to assess the functional outcome after tendon transfer surgery for radial nerve palsy. so investigators conducted a retrospective study at aga khan university hospital karachi comprising records of patients operated for irreversible high radial nerve palsy. investigators concluded that tendon transfer surgery for radial nerve palsy provides excellent results to restore the lost function and therefore must be considered for patients with no signs of recovery after the nerve repair.

Eligibility criteria:
inclusion criteria: * all participants including paediatric and adult age group with irreversible radial nerve palsy and patients with radial nerve palsy with time interval of more than 9 months were included. exclusion criteria: * all participants who underwent radial nerve repair or nerve grafting with or without internal splinting, patients with vascular injuries, muscular dystrophies, cva (cerebero-vascular accident), dementia and those with limited followup of less than 3 months were excluded.
budesonide for mycophenolic acid-induced diarrhea in renal transplant recipients

Conditions: Diarrhea

Summary: the purpose of this study is to learn if using a entocort (budesonide) to treat diarrhea will be effective and safe for kidney transplant patients, allowing them to continue with mpa medication.


Eligibility criteria:
inclusion criteria: * kidney transplant recipients \> 1 months post-transplant, * no history of chronic diarrhea pre-transplant, * \>3 watery/soft stools after transplant on at least 4 days in the week without anti-diarrheal for at least 2 weeks or using anti-diarrheals for at least 4 days in the week \> 2 weeks * subjects on at least 180mg twice a day of mycophenolate-sodium or 250 mg twice a day of cellcept exclusion criteria: * diagnosis of any known colonic diseases (i.e. crohn's disease, ulcerative colitis, ischemic colitis, celiac disease), partial colonic resection, small bowel resection, history of cholecystectomy, irritable bowel syndrome, fecal incontinence, bacterial overgrowth, infectious diarrhea (c difficle, cryptospora, giardia, isospora, human immunodeficiency virus), cytomegalovirus colitis * subjects with recent acute rejection treated with high dose steroids * subjects taking boswellia serrata extract, over-the-counter herbs, cholestyramine, nonsteroidal salicylates (other than daily asa) * subjects with active malignancy, liver cirrhosis, active peptic ulcer disease, known intolerance or resistance to budesonide, pregnancy, breast-feeding, mental retardation * unable to provide informed consent
high flow nasal cannula oxygen during sedation for video-assisted thoracoscopic surgery

Conditions: Chronic Obstructive Pulmonary Disease; Respiratory Failure

Summary: high-flow nasal cannula (hfnc) is a device that delivers10 to 70 l min-1 of heated, humidified 100% oxygen via nasal route. it provides positive airway pressure, decreases dyspnea, decreases the work of breathing, and improves comfort

beneficial effects of the hfnc system have been assessed based on 3 physiologic conditions: decreased dead space, a high concentration of inspiratory oxygen, and positive pressure in the oro-laryngeal cavity.studies have shown that it improves oxygenation in various perioperative settings such as the apneic patients, patients with respiratory failure , and patients undergoing bronchoscopy

Eligibility criteria:
inclusion criteria: * asa physical status ii and iii, * undergoing vats exclusion criteria: * refusal of patients * extrem of age
beadi - the bliss cluster randomised control trial on the effects of active dissemination of information (beadi)

Conditions: Premature Babies

Summary: beadi is a dissemination trial, on standards of care of premature babies. the main objective of beadi is to assess whether an innovative 'active' strategy for the dissemination of neonatal information (evidence reviews, interactive training workshop, benchmarking and feedback, and ongoing support) is more likely to lead to changes in policy and practice than the traditional (more passive) forms of dissemination in english neonatal units. beadi will focus on three areas of neonatal care for premature (22+0 to 26+6 weeks' gestation) babies born in england: timing of surfactant therapy, staffing for resuscitation at delivery, and temperature control (in line with the main project 27/28 findings ). however, the approach is applicable to a wide variety of clinical policies and practice. the beadi study has been granted ethical approval by mrec to use a subset of data collected by epicure2 up until 31st december 2006 (pre-intervention data). for the post-intervention data, ethical approval has been granted for cemach to continue data collection against the three clinical areas using a subset of data items captured in the pn:e2 form, for the three month period between 1st january - 31st march 2007. local research and development departments of each trust have also been contacted.


Eligibility criteria:
inclusion criteria: * hospital staff : lead neonatologist for clinical governance in each maternity hospital in england. * babies born in england before 27 weeks gestation between january 2006 - 31st march 2007

Keywords: neonatal premature babies healthcare research babies born before 27 weeks gestation
survival study after out-of-hospital cardiac arrest

Conditions: Out-of-Hospital Cardiac Arrest

Summary: the purpose of this study is to determine if dual dispatch of ambulance, fire fighters and/or police in out-of-hospital cardiac arrest (ohca), can reduce the time to cardiopulmonary resuscitation (cpr) and defibrillation, thus increasing survival.

hypothesis if simultaneous dispatch of ambulance (ems), firefighters and/or police is being initiated when an ohca occurs, then the two latter units will be first at scene, before the ambulance crew, in ≥30% of the cases. we anticipate therefore that overall 30-days survival will increase on a national level from 9% to 12%. method during the period 110901 to 141231 all ohca cases will be analyzed were the emergency medical communication centre (emcc) has dispatched ambulance, firefighters and/or the police. participating in the saving more lives in sweden (sams) project are the following counties: stockholm, sodermanland, jonkoping, vastra gotaland (vg region), halland, dalarna, jamtland, kalmar and uppsala. data is collected by the units being dispatched and thereafter sent on line to a database managed by registercentrum in gothenburg (http://www.registercentrum.se/), administrators of the swedish cardiac arrest register. parameters obtained are: * time for dispatch of fire fighters and/or police (recorded digitally). * time for arrival to the patient. * verification if cardiac arrest or not. * cpr performed by fire fighters or police before arrival of ems. * automated external defibrillator (aed) connected to the patient. * if yes, was the first recorded rhythm shockable, i.e. ventricular fibrillation (vf) or pulseless ventricular tachycardia (vt). * time to defibrillation. survival data during from the swedish cardiac arrest register (scar) will be obtained during the same time period from nine comparable swedish regions not participating in the sams study.

Eligibility criteria:
inclusion criteria: * all cases where the dispatcher suspects cardiac arrest, i.e. unconscious person with abnormal or no breathing exclusion criteria: * children \< 8 y * obviously deceased persons according to regulations in ems protocols

Keywords: cardiac arrest out-of-hospital cardiac arrest firefighters police defibrillators survival
idiopathic pulmonary fibrosis and serum bank

Conditions: Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial

Summary: idiopathic pulmonary fibrosis (ipf) is the most common form of chronic idiopathic diffuse interstitial lung disease (dild) in adults. it is a fibroproliferative, irreversible disease of unknown cause, usually progressive, occurring mainly from the age of 60 and limited to the lungs. ipf is a serious disease with a median survival rate at diagnosis of 3 years. the aim of the study is to set up a biocollection of serum from patients in a context of idiopathic dild and a possible or confirmed diagnosis of common interstitial lung disease by chest ct. patients will be recruited at the consultations of the rennes rare lung disease competence centre. these will be patients in stable condition or in acute exacerbation of ipf.

this study will initially focus on circulating serum cd163 markers, but a broader proteomics approach could be considered in a second phase to look for other markers of lung diseases.

Eligibility criteria:
inclusion criteria: * patients seen on an outpatient basis and in stable or acute condition * patient over 18 years of age. * the inclusion criteria will be those edited by the american thoracic society (ats) and the european respiratory society (ers) to diagnosis ipf exclusion criteria: * patients who are unable or unwilling to sign the consent.

Keywords: biomarkers cd163
a study of aflibercept in combination with folfiri in patients with second-line metastatic colorectal cancer in japan

Conditions: Colorectal Cancer Metastatic

Summary: primary objective: to assess efficacy aflibercept + 5-fluorouracil (5-fu)/levofolinate/irinotecan (folfiri) by objective response rate (orr). secondary objective: to assess the following: * safety profile; * progression free survival (pfs); * overall survival (os); * pharmacokinetics (pk); * immunogenicity.

screening was up to 24 days. treatment period was continued until dp, unacceptable toxicity, or participant's refusal. follow up period was continued until death, participant's refusal, or end of study, whichever came first. this trial was conducted in japan, where the international nonproprietary name (inn) designation for the study molecule is "aflibercept" and this term is therefore used throughout the synopsis. in the us, the us proper name is "ziv-aflibercept".

Eligibility criteria:
inclusion criteria: * histologically or cytologically proven adenocarcinoma of the colon or rectum. * metastatic disease that was not amenable to potentially curative treatment. * participants with measurable disease. * one prior chemotherapeutic regimen (containing oxaliplatin) for metastatic disease. * participants who relapsed within 6 months of completion of oxaliplatin-based adjuvant chemotherapy were also eligible. exclusion criteria: * prior therapy with irinotecan. * less than 28 days elapsed from prior radiotherapy, prior surgery, or prior chemotherapy to the time of registration. * unresolved toxicity (grade \>1) from prior anticancer therapy. * eastern cooperative oncology group (ecog) performance status \>1. * brain metastases, uncontrolled spinal cord compression, or carcinomatous meningitis. * other prior malignancy. * pregnant or breast-feeding women. * uncontrolled hypertension. * inadequate bone marrow function, liver function, or renal function. the above information was not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.
corneal endothelium evaluation after phacoemulsification in diabetec and non-diabetic patients with pseudoexfoliation

Conditions: Pseudoexfoliation

Summary: our study is a comparative study, that was conducted to evaluate the corneal endothelial cells changes and central corneal thickness after uncomplicated phacoemulsification and intra ocular lens (iol) implantation in normal controls, in non-diabetic and diabetic patients with pex, and in patients with pex only using specular microscopy.

our study is a comparative study that included 4 groups (controls, patients with pex, non-diabetic patients with pex, diabetic patients with pex) to evaluate the corneal endothelial cells changes and central corneal thickness after uncomplicated phacoemulsification and intra ocular lens (iol) implantation using specular microscopy, over a 6 months follow up period.

Eligibility criteria:
inclusion criteria: * senile cataract with age between 50 to 70 years * clear cornea with no zonuler dehiscence * lens opacity classification system iii (locs iii), with grade 2-3 nuclear cataract with any additional cortical (c) and posterior sub capsular (p) exclusion criteria: * uncontrolled dm in diabetic groups * presence of autoimmune diseases * patients with glaucoma * corneal guttata * zonular dehiscence * rupture posterior capsule during cataract surgery

Keywords: dm phacoemulsification endothelial cell density
examining the link between heart disease and hiv infection in women

Conditions: Cardiovascular Diseases; Atherosclerosis; Acquired Immunodeficiency Syndrome; HIV Infections

Summary: recent studies have shown that hiv infected individuals have an increased risk of developing heart disease, but the reason for this is not fully understood. this study will examine ultrasound test results of blood vessels and laboratory data of hiv infected and hiv uninfected women to examine the link between heart disease and hiv infection.

hiv infected individuals are at increased risk for developing atherosclerosis, which is a build-up of plaque within the arteries and which may lead to various forms of heart disease. it is unknown, however, why individuals with hiv are more susceptible to heart disease compared to others. atherosclerosis may develop more rapidly due to hiv infection, the use of antiretroviral medications, or a combination of the two. hiv lipodystrophy syndrome, in which body fat distribution is altered, may also be a risk factor. if heart disease is not properly treated, individuals place themselves at risk for heart attacks, strokes, or organ failure. in previous studies involving hiv and heart disease, women have been under-represented. this study will examine a group of women participating in the women's interagency hiv study (wihs), which is examining the impact of hiv infection and its clinical, laboratory, and psychosocial effects in women. by using ultrasound imaging, the progression of subclinical atherosclerosis will be assessed. wihs study data will then be used to examine possible relationships between atherosclerosis and factors associated with hiv infection in women. the results of this study will have major implications for the development of strategies to predict, prevent, or reverse atherosclerosis and heart disease in hiv infected individuals. this 4-year study will enroll 750 hiv infected women and 250 hiv uninfected women who are participating in the wihs study. participants will undergo an initial ultrasound imaging of the neck to measure the size and thickness of the arteries. they will return for a repeat ultrasound at years 2, 3, and 4 to assess any progression of atherosclerosis. data from the participants' biannual wihs study visits, including hiv medication usage, viral load and cd4 test results, and occurrence of aids and other illnesses, will be reviewed. results of participant's inflammation marker tests, which may indicate the presence of atherosclerosis, including white blood cell count, c-reactive protein, e-selectin, and intercellular adhesion molecule 1, will also be reviewed.

Eligibility criteria:
inclusion criteria: * women enrolled in the wihs hiv cohort study

Keywords: aids
laparoscopic total vs partial fundoplication in patients with atypical symptoms of gastroesophageal reflux disease

Conditions: Gastroesophageal Reflux Disease

Summary: one hundred and twenty patients with documented extraesophageal symptoms of gastroesophageal reflux disease were randomized to either undergo floppy nissen (n= 60) or toupet fundoplication (n= 60). symptom scores of extraesophageal symotoms and quality of life were prospectively evaluated. analysis of the treatment results showed a significant improvement of symptoms in both patient groups.quality of life improved substantially at short- and long-term follow up in both groups and there were no statistical differences between the groups in this parameter.


Eligibility criteria:
inclusion criteria: * extraesophageal symptoms of gastroesophageal reflux disease * undergoing surgery for gastroesophageal reflux disease * at least 18 years old exclusion criteria: * patients under the age of 18 years * previous anti-reflux surgery, other surgical procedures in the vicinity of the gastroesophageal junction * major psychiatric illness * unstable chronic illnesses (such as diabetes) * inability of the patient to complete the survey.