Kornimate/medical-research-clean huggingface dataset:
evaluation of human papillomavirus vaccine coverage in girls and young women with chronic disease

Conditions: Human Papillomavirus Vaccine; Chronic Condition

Summary: the main objective of the study is to determine the vaccination coverage rate for human papillomavirus in adolescents aged 11 to 20 with chronic disease and treated at the necker-enfants malades hospital, compared to a population witnessed adolescent girls aged 11 to 20 years without chronic disease.

girls and young women with chronic condition are at higher risk for infections that can be prevented by vaccination. human papillomavirus infection is very common, one of the three most common in the general population. a vaccine exists to significantly prevent this infection and its complications. in france, it is advisable to vaccinate girls and boys from the age of 9 years and as soon as possible in the case of acquired immunodeficiency since these patients are more likely to be suffering from cancer induced by the human papillomavirus. in france, the overall rate of vaccination coverage for girls is 21%, which is significantly lower than in several other industrialized countries. the vaccination coverage rate for human papillomavirus in patients with chronic diseases may be even lower. the main objective of the study is to determine the vaccination coverage rate for human papillomavirus in adolescents aged 11 to 20 with chronic condition and treated at the necker-enfants malades hospital, compared to a population witnessed adolescent girls aged 11 to 20 years without chronic disease.

Eligibility criteria:
inclusion criteria: * information and non-opposition of major patients and holders of parental authority of minor patients and minor patients * girls and young women aged 11 to 20 * to be followed at the necker-enfants malades hospital ("chronic condition" group) * to be followed at the specialized medical center for children and adolescents ("control" group) * have a chronic condition ("chronic condition" group) : * diabetes type 1 * metabolic diseases * patients followed in immuno-hematology * cystic fibrosis * sickle * kidney transplant * heart disease * inflammatory bowel diseases * rare anorectal and pelvic anomalies * live in france * comprehension of the french language (oral and written) exclusion criteria: * have a contraindication to the hpv vaccine - gardasil 9 (vidal hoptimal, 2018) * have a contraindication to the hpv vaccine - gardasil (vidal hopitmal, 2018) * have a contraindication to hpv vaccine - cervarix (vidal hoptimal, 2018)

Keywords: human papillomavirus vaccine young women with chronic condition vaccination coverage rate
effect of smart phone health education on overweight and obese schoolchildren's dietary habits and body composition

Conditions: Childhood Obesity

Summary: the aim of this study is to investigate the effect of mobile health nutrition education intervention in the changing of dietary habits and body composition of overweight and obese 8-12 years old children in sharjah, united arab emirates and to compare its effectiveness to paper educational intervention among the same age group. the main questions it aims to answer are: 1. are there any significant changes in dietary habits, physical activity and body composition among overweight and obese school-age children after three months of mobile health intervention? 2. is there any significant difference between the effect of smart phone delivered and paper delivered interventions (changes in dietary habits, physical activity and body composition) among overweight and obese school-age children after three months of interventions? 3. are there any significant changes in the obesity inflammatory panel among overweight and obese school-age children after three months of mobile health intervention? 4. is there any significant difference in the sustainability of the outcomes between mobile health and paper delivered interventions among overweight and obese school-age children two months after the end of the intervention? 5. are there any significant changes in nutrition related knowledge among parents of overweight and obese school-age children after three months of intervention? participants (children with their parents) will be randomly divided into intervention group and control group. parents of children from the intervention group will receive two text messages/graphics per week about healthy eating and physical activity (pa) on their mobile phones during the intervention period (3 months). while parents in the control group will receive a one-time printed handout containing the same messages at the beginning of the intervention period. assessment of children's anthropometry, dietary intake and physical activity will be evaluated pre and post intervention and one more time after a two months period of maintenance after the end of the intervention. parents' nutrition knowledge will be evaluated pre and post intervention only. also, children salivary obesity markers will be measured at baseline and at the end of the intervention period to explore the effects of the intervention on inflammatory markers associated with obesity.


Eligibility criteria:
inclusion criteria: * overweight/obese children (over 2 sd based on the who growth reference (2007)). * between 8 - 12 years old. * attending school in sharjah, uae. exclusion criteria: * children on a specific diet. * children who have any chronic diseases. parents qualify if their children meet the inclusion criteria, they can read and speak in arabic, they plan to stay in sharjah for six months from the beginning of the intervention, and they own and use a smart phone.
clinical observation of implementing the medgem into a medical specialty practice

Conditions: Obesity

Summary: due to common cvd diseases associated from obesity, medical providers are in a position to provide assistance. however, less than 10% of all patients receive any weight loss advice from physicians. perceived barriers to weight loss counseling include lack of self-control of their patients and belief that recommendation is futile, lack of medical training in nutrition, exercise, and obesity management, and lack of insurance reimbursement. though many barriers are prevalent, research has demonstrated a positive effect with medical advice on the number of obese individuals attempting to lose weight. analyzing data from the 1996 behavioral risk factor surveillance system, researchers found, when advised to lose weight by a physician, 78% of overweight patients reported attempting to lose weight. however, if their physician did not discuss weight loss, only 33% of patients within the same bmi category attempted to do so 7. from this information, physicians or allied health staff that provide brief counseling (5-10 minute) along with medical technology that provides basic nutrition assessment might have a positive impact on the number cvd patients that are obese attempting to lose weight. hypothesis: will a medical specialty clinic focused on cardiovascular medicine successfully be able to implement the medgem device for assessment of basic nutritional needs along with providing "brief" patient education into the medical practice without a house dietitian. primary aims 1. can medical staff and/or support staff provide ree assessments (15-minutes) and brief patient education (5-15 minutes) as part of the clinic's operations? 2. will a third-party payer compensate the medical specialty clinic for the diagnostic procedure cpt code 94690 for obese patients diagnosed with hypertension (401.1-9, 402.10-11, \& 402.90-91), hypercholesterolemia (272.1), and/or hyperlipdemia (272.2)? secondary aims 1. does self-efficacy increase from ree assessments? 2. do patients adopt healthy eating (calorie reduction and fat reduction)following ree assessments?


Eligibility criteria:
inclusion criteria: * patients with a bmi (body mass index \> 30.0 kg/m2) * patients diagnosed with any of the following icd-9 codes: hypertension (401.1), hypercholesterolemia (272.1), and/or hyperlipdemia (272.2-4) * patients diagnosed with a secondary icd-9 code: obesity (278) or morbid obesity (278.01) exclusion criteria: * patients that are pregnant * patients under the age of 18 years
biomarkers of liposomal doxorubicin induced hypersensitivity reaction in breast cancer patients

Conditions: Liposomal Doxorubicin Induced Hypersensitivity Reaction in Breast Cancer Patients

Summary: pegylated liposomal doxorubicin (pld) was an anthracycline nanomedicine to be approved for advanced breast cancer and other solid tumor therapy and showed a good disease control rate (57%). pld could induce hypersensitivity reaction (hsr). there are about 9-25% patients got infusion reaction or hsr. severe hsr could lead to allergic shock even presyncope or threat to life. to our knowledge, there were no sensitivity biomarker to predict the pld induced hsr. and the mechanism of pld induced hsr is unknown yet. therefore, to analyze and discuss the biomarkers and mechanism of pld induced hsr in advanced breast cancer, we design this prospective, observational, biomarker study.


Eligibility criteria:
inclusion criteria: * ≥18 years old; breast cancer confirmed with histological or molecular diagnosis; advanced breast cancer diagnosis according to american joint committee on cancer eighth edition cancer staging manual; treatment with liposomal doxorubicin; no pregnancy plan and voluntary use of effective contraceptive measures during treatment exclusion criteria: * subjects who discontinued treatment due to previous severe adverse reactions to liposomal doxorubicin or doxorubicin; poor compliance.

Keywords: liposomal doxorubicin hypersensitivity reaction breast cancer
eccentric exercise training as novel rehabilitation for chronic obstructive pulmonary disease (copd)

Conditions: Pulmonary Disease, Chronic Obstructive; Bronchitis, Chronic; Emphysema

Summary: the main purpose of this project is to establish the additional value of eccentric versus concentric exercise to optimize muscle function in patients with severe copd. with this pilot project the investigators expect that an eccentric endurance training protocol adapted to severe copd patients will lead to gains in muscle strength, the primary outcome, and cellular adaptation (muscle morphology and oxidative capacity, mitochondrial respiratory capacity) when compared to a concentric training approach. this information will be essential if the investigators want to design and power a randomized clinical trial that will allow assessing effectiveness of this novel rehabilitation approach.

chronic obstructive pulmonary disease (copd) is a major respiratory illness that is both preventable and treatable. dyspnea is the most important symptom that copd patients experience and this can have a major impact on their daily live. while copd is characterized by a spectrum of disease severity, most patients experience poor exercise intolerance attributable to ventilatory limitation as well as peripheral muscle fatigue, ultimately leading to severe disability. endurance exercise is an important component of pulmonary rehabilitation and is aimed at preventing this decline in functional capacity. the effects of pulmonary rehabilitation are largely attributable to the exercise training component involving concentric muscle contractions, traditionally trough dynamic, large muscle exercise on a cycle ergometer or treadmill. however, many patients are unable to partake and benefit from such rehabilitation because of locomotor muscle weakness and severe ventilatory limitation that prevent them from exercising at intensities sufficient to provoke improvements in cardioventilatory and skeletal muscle function. eccentric exercise is known for its unique physiologically fundamental characteristics: the lower metabolic demand for a same power output and greater muscle gains compared to the concentric exercise. for this reason, eccentric endurance training has been proposed as a novel adjunctive rehabilitative countermeasure for certain chronic diseases (such as coronary disease and copd) and can play an important role for patients with advanced disease.

Eligibility criteria:
inclusion criteria: * male patients with severe copd (fev1/fvc \< 0.70 and fev1 ≤ 50% predicted of normal) * patients aged 40 to 80 years old in whom exercise is not contraindicated * current and ex-smokers * patients who do not require oxygen therapy exclusion criteria: * patients presenting neurological or orthopedic problems, morbid obesity, acute medical condition or recent exacerbations (in the last four weeks) * patients with recent or current participation in a rehabilitation program

Keywords: copd eccentric exercise training cycle ergometer muscle function
ketogenic diet for traumatic brain injury

Conditions: Traumatic Brain Injury; Ketogenic Dieting

Summary: traumatic brain injury is a major health concern in united states. there is a un-met need to develop new therapeutic options for faster neuron recovery without causing significant side effects. the role of ketones in neuronal recovery has been studied and has been found to be useful in decreasing size of contusion. the present study aims to study the safety and feasibility profile of ketogenic diet.

traumatic brain injury (tbi) is a major health concern for united states contributing nearly one-third of injury-related deaths in united states. the centers for disease control and prevention (cdc) estimates that 1.7 million people in the united states sustain a tbi each year. it is responsible for significant disabilities and the total cost of productivity loss was estimated to be $76.5 billion in the united states in 2004. several animal models have demonstrated the effectiveness of ketones in brain injury to decrease the size of contusion, improving cortical atp levels, reduced brain edema and cellular apoptosis. ketones have been shown to be effective in neuromodulation in animal models. evaluation of carbohydrate free diet has been done in traumatic brain injury patients and it was noted to not cause fluctuations in blood glucose. there is a need for safety and feasibility study of ketogenic diet in traumatic brain injury patients and to understand the effectiveness in neuromodulation in humans. the present study focuses on identifying the safety and feasibility of kd in traumatic brain injury patients. this pilot project data will be utilized to design future randomized clinical trials. based on the safety data, further trials will be conducted to evaluate the effectiveness of kd in traumatic brain injury patients and its effectiveness in controlling elevated intracranial pressure. it will open the avenue for consideration of new treatment option for intracranial pressure management and functional recovery. from a nutrition perspective, ketogenic diet might become the standard of care for this patient population.

Eligibility criteria:
inclusion criteria: 1. severe traumatic brain injury 2. gcs\<= 8 with severe head injury 3. age more than 18years exclusion criteria: 1. diabetic ketoacidosis 2. unstable metabolic condition (persistent hyponatremia, hypernatremia, hypoglycemia, hypocalcemia, acidosis) 3. cardiorespiratory or hemodynamic instability 4. coagulopathy 5. pancreatitis 6. liver failure 7. severe hyperlipidemia 8. inability to tolerate enteral feeds including ileus 9. known fatty acid oxidation disorder or pyruvate carboxylase deficiency 10. any terminally ill patient with poor brain stem reflexes and mortality within 24h of admission. 11. pregnant females
effects of an emdr intervention on traumatic and obsessive symptoms

Conditions: Adult ALL; Post-traumatic Stress Disorder; Obsessive-Compulsive Disorder; Disgust; Guilt; Shame

Summary: the eye movement desensitization and reprocessing protocol (emdr) was first developed by francine shapiro in 1987 and can be adapted for online and in presence administration. the aim of this study is to assess if a emdr program (administered both online and in presence, depending on different conditions of patients) may help people recruited from general population suffering from covid19 second (november 2021 to february 2022) and third (march 2022 to may 2022) quarantine in improving post-traumatic stress (ptsd) and obsessive-compulsive-related (ocd) symptoms, as well as disgust, guilt, shame and their subjective unit of distress (sud) and validity of cognition (voc) levels.


Eligibility criteria:
inclusion criteria: 1. participants aged 18 to 75 years 2. participants experienced a full covid19 pandemic-related quarantine during red zones of the second and third lockdowns in italy 3. participants have reasonable comprehension of spoken and written italian language 4. participants have an adequate understanding of italian exclusion criteria: 1. concurrent enrollment in other intervention trials 2. participants that already experienced emdr therapy in the past

Keywords: ptsd ocd disgust guilt shame body emdr
trial comparing microdebrider-assisted inferior turbinoplasty (mait) vs submucous resection (smr)

Conditions: Nasal Obstruction

Summary: this is a prospective, patient blinded, randomized, clinical trial enrolling patients with symptoms and signs of nasal obstruction related to enlarged inferior turbinates. the purpose of this study is to compare two different surgical methods, both of which are already in common use, for the treatment of nasal obstruction in patients with inferior turbinate hypertrophy.


Eligibility criteria:
inclusion criteria: * symptoms of chronic nasal obstruction with an exam finding of turbinate hypertrophy, with or without septal deviation will be eligible for the study. * failed medical treatment * have failed medical treatment for at least 1 month, and will be offered surgery * patients having septoplasty at the same time as their turbinate reduction surgery. exclusion criteria: * patients who have had previous turbinate reduction surgery will be excluded. * patients that have nasal polyps, chronic rhinosinusitis, adenoid hypertrophy, nasal tumors, or any other exam finding that would explain their symptoms of nasal obstruction other than enlarged inferior turbinates with or without septal deviation will be excluded. * patients who are diagnosed with purely bony inferior turbinate hypertrophy as discussed below. * patients on hormone or anticoagulation therapy and those who have a history of head and neck radiation therapy will be excluded. * all study candidates will be assessed for external nasal valve collapse via the modified cottle maneuver, and will be excluded if they exhibit significant external or internal nasal valve collapse as their primary cause of their nasal obstruction. * all patients will complete the visual analog scale (vas) on nasal obstruction before and after decongestion at their preoperative visit. patients that fail to report a score less than 5 after decongestion are likely to have bony rather than soft tissue hypertrophy. in these patients mait is unlikely to be an adequate surgical option, and they would derive a greater amount of benefit from smr. therefore these patients will be excluded from the study, and offered only smr.
bio-seal biopsy track plug for reducing pneumothorax rates post lung biopsy procedure

Conditions: Pneumothorax

Summary: bs-1053 a prospective randomized multi-centered safety and efficacy evaluation of the bio-seal biopsy track plug for reducing pneumothorax rates post lung biopsy procedures

this is a multi-centered, randomized trial in patients receiving lung biopsies. patients will be randomized to either receive or not receive a bio-seal biopsy track plug after a lung biopsy per standard hospital protocol. this study is designed to demonstrate safety and efficacy of the bio-seal biopsy track plug in reducing pneumothorax rates post lung biopsy.

Eligibility criteria:
inclusion criteria: * the patient must meet all medical conditions for lung biopsy; * the patient must be at least 18 years of age; * the patient, or legal representative, must understand and provide written consent for the procedure; * the patient has a non-calcified, radiologically suspicious opacity or lung nodule, including a metastatic lung module, or mass of at least 1.0 cm in size; as determined by ct scan equipped with measurement software. suspicious nodules observed by ct scan are defined as non-calcified masses with convex borders, not known to be stable. suspicious nodules can also be defined as masses demonstrating opacity on chest x-ray that are suspicious by radiographic or clinical means and require biopsy. exclusion criteria: * patients with radiological findings of bullous emphysema located in the area of the anticipated biopsy and biopsy needle track; * patients who cannot tolerate mild sedation, possibly secondary to poor respiratory status; * female patients who are pregnant. note: patients of childbearing potential must have a serum or urine pregnancy test no more than one week prior to the biopsy procedure, and be instructed not to have unprotected sexual intercourse after the test until the biopsy procedure is completed. * patients who are uncooperative or cannot follow instructions. * patients who are currently enrolled in another ide or ind clinical investigation that has not completed the required follow-up period.

Keywords: lung biopsy
proximal roux-en-y gastrojejunal anastomosis on delayed gastric emptying after pylorus-resecting pancreaticoduodenectomy

Conditions: Pancreatic Cancer; Bile Duct Cancer; Duodenal Cancer

Summary: this study aims to evaluate whether the incidence of delayed gastric emptying (dge) can be reduced by proximal roux-en-y gastrojejunal anastomosis in comparison with the standard gastrojejunal anastomosis in pylorus-resecting pancreaticoduodenectomy (prpd).

delayed gastric emptying (dge) is a common complication after pancreaticoduodenectomy (pd), occurring in 20% to 70% of the patients. dge is usually not a life-threatening complication, but it contributes significantly to increased length of hospital stay, health care costs, and patient discomfort. in a recent study by sakamoto et al, proximal roux-en-y gastrojejunal anastomosis is associated with a reduced incidence of dge after pylorus-resecting pancreaticoduodenectomy (prpd); however, these results may have been biased because of the retrospective nature. therefore, the investigators conducted the present randomized controlled trial (rct) to evaluate the impact of the proximal roux-en-y gastrojejunal anastomosis on reducing dge following prpd.

Eligibility criteria:
inclusion criteria: * patients who were scheduled to undergo pd and provided written informed consent. * in the opinion of the surgeon, the subject has no medical contraindications to pd. * at least 18 years of age. exclusion criteria: * patients who underwent other surgical procedures than pd, such as total pancreatectomy (tp) or a palliative biliary and gastroenteric anastomosis. * drug abusers or alcoholics. * patient who have previous transabdominal surgery. * the patient who were scheduled to undergo laparoscopic pd. * the patient who does not want to participate the clinical trials.

Keywords: delayed gastric emptying pancreaticoduodenectomy