Kornimate/medical-research-clean huggingface dataset:
eccentric exercises for shoulder pain

Conditions: Shoulder Pain

Summary: patients will be randomly assigned to one of two groups using a random number generator. group 1 will be provided with in-office instruction of standard of care eccentric exercises for rotator cuff tendinopathy. group 2 will be provided with in-office instruction as well as a instructional exercise video source (dvd) to take home as a reminder on how to perform two specific standard of care eccentric exercises for rotator cuff tendinopathy. each group will be given a card to track adherence to the standard of care eccentric exercise routine as measured only by the days that they accomplish their exercises. study exercise diary will be collected after 12 weeks of treatment. eccentric exercises are taught as part of standard of care for rotator cuff tendinopathy.

dod beneficiaries age 18 or older will be recruited from the clinics at the mike o'callaghan federal medical center (mofmc). subjects meeting the inclusion/exclusion criteria will be offered an opportunity to participate: screening visit: * obtain signed informed consent document and hipaa authorization. * verify inclusion/exclusion criteria visit 1 (may occur same day as screening visit): * subjects will be randomly assigned to one of two groups by the research coordinator using a random number generator, thus the investigators will be blinded to the group assignments: * group 1: in-office instruction of the standard of care eccentric exercise regimen for rotator cuff tendinopathy. * group 2: in-office instruction of the standard of care eccentric exercise regimen for rotator cuff tendinopathy and an instructional exercise video source (dvd). * subjects will be given a study exercise diary to track adherence to the standard of care eccentric exercise routine. visit 2 (12 weeks post visit 1): • study exercise diary will be collected to assess adherence. if the subject is unable to come in, they can return the study exercise diary via mail, or electronic mail.

Eligibility criteria:
inclusion: * dod beneficiary patient 18 years or older * diagnosis of chronic (\>30 days) shoulder pain of any etiology (traumatic vs over-use injury) exclusion: * patients \< 18 years of age * patients with acute injury (fracture or injury within 30 days) * patients unable to accomplish eccentric exercise regimen without assistance * patients unable to view dvd * pregnant women * patients unable to read and/or understand english
to establish a blood transfusion prediction model for liver transplantation patients based on pbm

Conditions: Blood Transfusion Complication

Summary: based on the principle of patient blood management, this study aims to reduce the risk of blood transfusion in allogeneic liver transplantation patients, to ensure the safety of blood transfusion, and to provide new methods and basis for restrictive blood transfusion.

1. preoperative variables and statistical analysis of a large number of intraoperative blood transfusions in allogeneic liver transplantation patients were performed to screen preoperative variables. 2. models were established by machine learning algorithms to predict a large number of blood transfusions during surgery, providing a reference for preoperative blood preparation and postoperative outcome.

Eligibility criteria:
inclusion criteria: * 48h preoperative biochemical indicators, blood general indicators, coagulation test complete exclusion criteria: * 1. inspection information is not detailed 2. blood transfusion information is not detailed 3.postoperative medical record information is not detailed

Keywords: liver transplantation blood transfusion patient blood management
acupuncture outcomes based rehabilitation

Conditions: Pain

Summary: can acupuncture be quantified. this study sets out to observe if there are measurable effects of fine motor control that are attributable to acupuncture. the study utilizes an fda approved medical device for measurements of fine motor control called the ru-fit.

context: currently there is a high demand for evidence-based research in the field of acupuncture. the medical practice of acupuncture has existed for thousands of years and purportedly has been successful at managing a wide array of health conditions. producing objective/quantitative data that rule out any possibility of placebo effect has proved burdensome. objectives: this exploratory study seeks to determine if physiological measurements of fine motor control can be changed after receiving an acupuncture treatment. can this change demonstrate the effectiveness of the treatment? design, setting, participants, interventions: this study looked at acupuncture patients undergoing treatments for pain relief, and general minor injury to determine whether or not observable changes could be detected in the fine motor control of the hands after acupuncture treatments. two groups of 50 subjects were used in the study. the test group was given a fine motor control test prior to and after their acupuncture therapy to determine if any changes could be measured. the control group was given two fine motor control tests without acupuncture treatment with a 40 minute delay between the tests to replicate the test group timing. this study was conducted at a non-profit community clinic between the dates of 9/28/16 \& 2/19/17.

Eligibility criteria:
inclusion criteria: * male or female 13 years old or older * study participants were selected from the acupuncture patient population freely visiting the clinic. patients were asked if they would be interested in a research study. they were informed about the objectives of the study, what their role would be and that this was a free non-invasive test that they would undergo before and after their regular acupuncture treatment. before inclusion into the program, patients are provided with informed consent forms and after agreeing and signing the form, individuals then become participants. exclusion criteria: * younger than 13 years old

Keywords: acupuncture quantitative data outcomes based rehabilitation fine motor control
validation of a model for predicting duodenal stump leakage after gastrectomy

Conditions: Gastric Cancers

Summary: this study aims to validate a machine learning model for predicting duodenal stump leakage after laparoscopic radical gastrectomy for gastric cancer.

gastrectomy is an essential procedure in radical surgery for gastric cancer. duodenal stump leakage (dsl) is one of the critical short-term complications after distal and total gastrectomy in gastric cancer patients. identifying patients with high-risk of dsl will assist the surgeons' decision making to give efficient previous intervention, such as a more rigorous operation, placing dual-lumen flushable drainage catheter and decompression tube in afferent loop. investigators have developed a high-performance machine learning model based on 4070 gastric cancer patients, which showed good discrimination of dsl. hence, this multi-center prospective study will validate the reliability of this model for predicting dsl in gastric cancer patients who receive laparoscopic distal or total gastrectomy.

Eligibility criteria:
inclusion criteria: 1. aged older than 18 years and younger than 85 years 2. primary gastric carcinoma confirmed by preoperative pathology result 3. expected curative resection via laparoscopic distal or total gastrectomy and reconstruction via billroth-ii or roux-en-y anastomosis 4. american society of anesthesiologists (asa) class i, ii, or iii 5. with full documents of preoperative examinations such as blood test and abdominal ct scanning 6. written informed consent exclusion criteria: 1. pregnant or breastfeeding women. 2. severe mental disorder or language communication disorder. 3. other surgical procedures of gastrectomy is performed. 4. interrupted of surgery for more than 30 minutes due to any cause. 5. malignant tumors with other organs 6. performed gastrectomy in the past

Keywords: artificial intelligence gastric cancer duodenal stump leakage radical gastrectomy
the role of oxytocin in regulating blood glucose

Conditions: Glucose Metabolism Disorders (Including Diabetes Mellitus)

Summary: investigating the effect of oxytocin on pancreatic endocrine functions by determining insulin and glucagon secretion within physiological ranges of plasma glucose.

insulinotropic effects of oxytocin will be examined in 20 healthy men with body mass index (bmi) \< 27 kg/m2, during a graded glucose infusion test with concomitant intravenous infusion of synthetic oxytocin or placebo in a randomized, double-blinded design. this will determine the effect of oxytocin on glucose-stimulated insulin and glucagon secretion. additional changes in plasma/serum concentrations of c-peptide, glucose, glucose-dependent insulinotropic polypeptid (gip), glucagon-like peptide 1 (glp-1), and lipids will be assessed.

Eligibility criteria:
inclusion criteria: * bmi 19-25 kg/m2 exclusion criteria: * diabetes * heart-, liver or kidney disease * more than 14 units of alcohol weekly, or drug abuse * smoking or any kind of nicotine products * alanin aminotransferase (alat) ≥ 2 × normal range * estimated glomerular filtration rate (egfr) \< 60 ml/min/1,73m2 or creatinine above normal range * blood pressure \> 140/90 * hemoglobin \< normal range * corrected qt interval (qtc) \>0,45 sec. at electrocardiogram (ecg) at screening * known disease in the pituitary gland or previous pituitary surgery * any other disease/condition which the trial managers believe may affect participation in the trial

Keywords: oxytocin blood glucose glucose stabilization
pmcfu of an annular closure system

Conditions: Lumbar Disc Herniation

Summary: the purpose of this retrospective chart review study is to collect the data that will be used to provide clinical evidence to support the post-market surveillance program.

retrospective chart review of patients treated with lumbar discectomy and annular closure. review of patient charts through 3 month post op, for analysis of symptomatic lumbar reherniation at the index level.

Eligibility criteria:
inclusion criteria: * records for any subject treated with a barricaid annular closure device will be considered for inclusion into the study exclusion criteria: * records for any subject treated without a barricaid annular closure device will be considered for exclusion
impact of complete surgery of colorectal deep infiltrating endometriosis on fertility

Conditions: Endometriosis; Infertility

Summary: the endofert study is an open, multicenter, randomized, parallel-group, controlled trial. this study includes patients presenting colorectal die and infertility. patients will be randomized in two parallel-groups; one group underwent complete surgery of colorectal die prior to art and the other group underwent art alone (ratio 1:1)


Eligibility criteria:
inclusion criteria: * primary and secondary infertility * indication for ivf * persistent pain related to endometriosis with analgesic medical treatment failure * persistent pain including at least one of the following digestive symptoms related to endometriosis: dyschesia / sub-occlusive syndrome / rectal bleeding / painful defecation * colorectal deep infiltrating endometriosis : whatever lesion size / with at least rectal serosal involvement / confirmed by mri and 1 different investigation: vaginal ultrasound echography or coloscopic ct scan or rectal endoscope ultrasound * eligible for die surgery exclusion criteria: * contraindication to pregnancy or to ivf * viral risk * previous ivf cycle(s) * previous colorectal surgery * need of myomectomy during surgery * the use of oocytes donor

Keywords: deep infiltrating endometriosis endometriosis surgery in vitro fertilization
repair versus augmentation of partial acl tear

Conditions: ACL Injury

Summary: comparison between acl repair and acl augmentation in symptomatic patients with partial acl injury


Eligibility criteria:
inclusion criteria: * age from 15 to 50 years old * partial acl tear without any other ligament injury * with and without meniscal tear * with and without knee deformity * recent and chronic injury exclusion criteria: * younger than 15 and older than 50 y * multiligament injury * complete acl tear * failed acl reconstruction or repair
central venous pressure (cvp) changes do not predict preload unresponsiveness

Conditions: Cardiovascular Shock

Summary: passive leg raising (plr) is routinely used to predict preload responsiveness in critically ill patients. however, real-time measurements of cardiac output are required to assess its effects. some authors have suggested that in fluid non-responders, central venous pressure (cvp) increased markedly. by analogy with the cvp rules proposed by weill et al to assess a fluid challenge, it has been hypothesized that an increase in cvp ≥ 5 mmhg during plr can predict preload unresponsiveness. objective investigation of whether an increase in cvp ≥ 5 mmhg during plr predict preload unresponsiveness diagnosed by the absence of increase in velocity-time integral (vti) of the flow in the left ventricular outflow tract by more than 10% (4). methods critically ill patients with a central venous catheter in place and for whom the physician decided to test preload responsiveness by plr were prospectively included. transthoracic echocardiography was performed to obtain vti. the cvp and vti were measured before and during plr.


Eligibility criteria:
inclusion criteria: * adults * patients presenting with shock or other signs of circulatory failure (tachycardia, oliguria) * need for the physician to test preload responsiveness * patients already equipped by a central venous catheter for the measurement of cvp exclusion criteria: * patients\<18 years old * pregnancy * instaility justifying rapid increase in cathecolamines
emg training for altering activation patterns after stroke

Conditions: Stroke; Weakness, Muscle; Coordination Lack

Summary: evaluation of a new emg controlled game to improve hand function in chronic stroke survivors.

increased impairment of the hand is commonly reported as an outcome occurring after a stroke. this impairment is due mainly to the decreased ability to modulate appropriate muscle activation patterns. issues with appropriately modifying activation patterns can profoundly affect tasks of daily living. this study is evaluating a novel software focusing on retraining hand muscle activation patterns through an electromyographic (emg) controlled game. stroke survivors with chronic, severe hemiparesis of the hand will participate in a longitudinal study consisting of 3 weeks of training. we hypothesize that stroke survivors will experience a decrease in time to complete a test of emg control, as well as improvement in hand motor control.

Eligibility criteria:
inclusion criteria: * single, unilateral stroke at least 6 months prior to enrollment * moderate hand impairment defined by stage 4 or stage 5 on the chedoke mcmaster stroke assessment scale exclusion criteria: * visual neglect or deficits (with inability to compensate) * upper extremity orthopedic conditions that interfere with movement * cerebellar stroke children, prisoners, or adult unable to provide consent will not be recruited. as the procedures pose no increased risk for pregnant women, we will not specifically exclude them.

Keywords: hand stroke therapy rehabilitation
effect of guided imagery and progressive muscle relaxation as a means to improve the psychological well-being and the quality of life for patients with breast and prostate cancer

Conditions: Breast Cancer; Prostate Cancer

Summary: the purpose of this study is to determine whether guided imagery and progressive muscle relaxation techniques are effective in the management of pain, fatigue, nausea-vomit, anxiety and depression in patients with either prostate or breast cancer. this study includes a total of 200 patients with prostate and breast cancer randomly assigned to either a control or intervention group. the intervention group received in total 4 sessions of guided imagery (protocol floating on a cloud) and progressive muscle relaxation (breathing exercises and use of 11 groups of muscle progressively tensing and relaxing). measurements included the assessment of pain, fatigue, nausea-vomit, depression, anxiety and quality of life. additionally, saliva samples were collected prior and after the sessions as to assess saliva cortisol and saliva α-amylase. the same measurements were received by the patients of the control group as to allow comparisons.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of breast or prostate cancer * must be able to follow instructions * good cognitive ability * willing to participate exclusion criteria: * use of cortisone * xerostomia * oral mucositis

Keywords: guided imagery progressive muscle relaxation complimentary and alternative medicine quality of life stress pain anxiety
leucine-enriched branched-chain amino acid on muscle thickness, interleukin-6, sofa score in critical illness

Conditions: Critical Illness; Muscle Wasting

Summary: the goal of this clinical trial study is to test effects of leucine-enriched branched-chain amino acid (bcaa) in critically ill patients. the main questions it aims to answer are: • how are the changes in muscle thickness between groups at baseline and end of study • is there a decrease in interleukin-6 levels between groups at baseline and end of study • is there a decrease in sequential organ failure assessment score between groups at baseline and end of study. participants will be given leucine-enriched branched-chain amino acid 40 g/day enterally or parenterally for 10 days. researchers will compare with control groups to see if there is any changes between groups at baseline and end of study.

the goal of this clinical trial study is to test effects of leucine-enriched branched-chain amino acid (bcaa) in critically ill patients. the main questions it aims to answer are: • how are the changes in muscle thickness between groups at baseline and end of study • is there a decrease in interleukin-6 levels between groups at baseline and end of study • is there a decrease in sequential organ failure assessment score between groups at baseline and end of study. participants will be given leucine-enriched branched-chain amino acid 40 g/day enterally or parenterally for 10 days. researchers will compare with control groups to see if there is any changes between groups at baseline and end of study. both groups will be given standard nutrition with target energy of 20 kcal/kg bodyweight(bw)/day and ratio of nitrogen:non-protein calorie 1:70 and neuromuscular electrical stimulation 30 minutes per day.

Eligibility criteria:
inclusion criteria: * new admission to intensive care unit (icu) in first 24 hours * aged 18-65 years * sofa score \>= 4 exclusion criteria: * pregnant * ultrasound examination cannot be performed under these circumstances: deformities, open wounded, prosthetics on right leg, amputated above right patella * body mass index \<16 kg/m2 * chronic kidney disease stage 3-5 * diabetes mellitus uncontrolled blood glucose (bg) (bg \>200 mg/dl) * neuromuscular diseases with musculus quadriceps femoris dextra paralysis * autoimmune diseases * referral from another icu

Keywords: leucine branched-chain amino acid muscle wasting critically-ill patients muscle thickness interleukin-6 sequential organ failure assessment score
nowox oxygen therapy monitoring device

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the purpose of this study is to evaluate the duration of oxygen use recorded by the nowox, under usual conditions of daily living, in patients with chronic obstructive respiratory disease requiring oxygen therapy.

long term oxygen therapy (ltot) is one of the main non pharmacologic treatments for patients with severe lung disease. this continuous or sub-continuous oxygen supplementation is generally introduced at home in patients who have chronic cardio respiratory failure and severe resting hypoxemia to maintain sufficient blood oxygenation and therefore preserve vital organ function. ltot effectiveness has mainly been evaluated and documented in patients with copd, which also accounts for most of its prescriptions. in these patients, ltot has been shown to have a beneficial impact on haemodynamics, exercise capacity, lung mechanics and mental state. its implementation was furthermore associated with reduced yearly hospitalisation days and increased survival measuring adherence is an extremely important and under-evaluated component of oxygen therapy. nowox, medical device has been designed,developed and manufactured to measure adherence to ltot and additionally to measure patient's respiration rate

Eligibility criteria:
inclusion criteria: * male or female patient aged ≥ 18 years and ≤ 75 years, * having a documented diagnosis of moderately severe to severe chronic obstructive respiratory disease * hospitalised or out-patient requiring transient or long term oxygen therapy, * able to be weaned from oxygen for several consecutive minutes (around 30 minutes, spo2 at rest on room air should not drop \< 85%), * able to read * willing and able to complete the requirements of this study including providing his/her signature for the written informed consent. exclusion criteria: * clinically unstable patient, * any contraindication to perform a light cycling exercise, according to the 2003 ats/accp guidelines * tracheostomy, * nasal obstruction or acute rhinitis occurring in the week prior to selection, * for female patient: * pregnant, * positive urinary pregnancy test * lactating mother or lack of efficient contraception * clinically significant or uncontrolled cardiac, hepatic, renal, gastrointestinal, endocrine, metabolic, autoimmune, neurological or psychiatric disorders which may interfere with the study procedures, * known allergic reactions to medical material compounds used in the study * drug abuse or psychic disorders * legal status which prohibits informed consent, * participation in any interventional clinical trial within 30 days prior to selection.

Keywords: to verify accurrancy of data collected by the nowox
comparison between sutureless and glue free versus sutured limbal conjunctival autograft in primary pterygium surgery

Conditions: Pterygium

Summary: pterygium is a common ocular pathology facing ophthalmologists that has varied surgical management techniques and high rate of post-operative recurrence. the investigators aim was to compare and evaluate the safety and efficacy outcomes of those two surgical procedures in management of primary pterygium.

design: prospective randomized clinical trial comparative study. setting: department of ophthalmology, al-minia university faculty of medicine, egypt. methods: the study included 150 eyes of 150 patients of primary pterygium. twenty four to 74 years of age (mean 49 ± 12 years). simple excision under local anesthesia was performed then closure of the bare sclera by sutureless and glue free conjunctival autograft in 50 eyes of 50 patients (group 1), versus sutured free conjunctival autograft in 100 eyes of 100 patients (group 2).

Eligibility criteria:
inclusion criteria: patients complaining of primary pterygium with eye redness. patients with pterygium threatening the visual axis. exclusion criteria: all cases not completed the follow up period for two years. atrophic pterygium, pseudopterygium or double head pterygium.

Keywords: pterygium surgery sutureless glue free conjunctival autograft amniotic membrane graft.