Kornimate/medical-research-clean huggingface dataset:
combined triple procedure in retinal vein occlusion (rvo)

Conditions: Retinal Vein Occlusion

Summary: the aim of this pilot study was to investigate the effects of an intravitreal combination therapy using triamcinolone and bevacizumab in patients with retinal vein occlusion (rvo).

this prospective study of a case series was conducted in 47 patients (n = 47 eyes; f/m: 21/26; mean age: 66.6 years) with ischemic central rvo (crvo) (n = 15), non-ischemic crvo (n = 7), or branch rvo (brvo) (n = 25). a core pars plana vitrectomy with aspiration of 1.5 ml vitreous and infusion of balanced salt solution (bss; 1 ml), 8 mg (0.4 ml) triamcinolone, and 1.25 mg (0.1 ml) bevacizumab was performed with a single sutureless sclerotomy and a 23 gauge probe tip. at baseline and follow-up, the best corrected visual acuity (bcva; 6 m snellen), and intraocular pressure (iop; goldmann tonometry), and central macular thickness (optical coherence tomography) were determined. in addition, the need for further treatment and adverse events were monitored.

Eligibility criteria:
inclusion criteria: * ischemic central rvo (crvo) * non-ischemic crvo * branch rvo (brvo) exclusion criteria: * visual deterioration due to acute or chronic inflammation * post trauma * macular edema of other origin * intravitreal drug treatment within last 4 months
the effect of kinesiotaping method on feeding of late preterm infants.

Conditions: Preterm Infants

Summary: problems such as poor nutrition, weak sucking, lack of suck-swallow-respiration coordination, low weight gain are among the factors increasing the risk of morbidity in late preterm infants. early support of sucking and swallowing muscles for the development of suck-swallow coordination can shorten the maturation process and provide early discharge of late preterm infants. the aim of this study is to document kinesiotape technique to support sucking and swallowing muscles for treating nutritional problems and for reducing nutrition risks and accelerating maturation. according to power of analysis of this study, 74 infants planned to assign to kinesiotaping group or control group randomly. in kinesiotaping group, infants feeding performance will be evaluated by measuring the amount of milk invested, maximum heart rate, oxygen saturation, speed of milk intake and counting the number of swallow during feeding. kinesiotape will be applied to masseter and hyoid muscles 24 hours later after the birth of the infant. infants will be evaluated before kinesiotape application, 3 hour later and 24 hour later after the application.


Eligibility criteria:
inclusion criteria: * infants born in baskent university ankara hospital, age between 34-36.6 weeks. exclusion criteria: * infants with multiple kongenital anomaly, hypoxic ischemic encephalopathy, intraventricular and intracranial hemorrhage, necrotizing enterocolitis, tracheoesophageal fistula, diaphragmatic hernia, hydrocephalus, and respiratory distress.

Keywords: preterm infants kinesiotape swallowing
the study of wound dressings for portable npwt

Conditions: Pressure Ulcer; Diabetic Foot Ulcer

Summary: introduction negative pressure wound therapy (npwt), also known as topical negative pressure, has become a popular therapy for the treatment of many acute and chronic wounds. in many randomized controlled trials(rcts), npwt also has benefit in diabetic foot ulcer and pressure ulcer. however, most studies used commercial vac device in combined with polyurethane (pu) foam. it is not yet clear where npwt combined with gauze as wound filler is as effective as the pu foam. this rct evaluated the efficacy of the gauze and pu foam, two kinds of fillers routinely used in negative pressure wound therapy, on the healing of the diabetic lower-extremity ulcers and the pressure ulcer. methods from 2010/1 to 2015/01, the in-patient persons with difficult to heal diabetic ulcer or grade 4 pressure ulcer were enrolled. these patients were divided into two groups randomly. the letter of consent was signed by the patient or patient's family. after debridement of the infective wound, the wound of experimental group was packed with a moistened polyhexamethylene biguamide (phmb) impregnated gauze (kerlix amd, covidien). a noncollapsible drainage tube (blake drain, ethicon) was applied to the wound, and then sealed with 3m tegaderm film. the system was connected to a 1-bottle water-seal chest drainage system and to standard wall suction at 125 mmhg negative pressure. the dressing was changed at 72- to 96-hour intervals (twice a week) for a period of 3 weeks. to the control group, the pu foam dressing from kci was packed and sealed to the wound with the same continuous wall suction at -125mmhg. investigators observed and recorded the ulcer area twice a week on each time of changing dressing in the following 3 weeks. the percentage of wound area reduction(pwar) was used as a predictor of wound healing. the repeated measuring data were analyzed using linear mixed mode with spss statistical software. this clinical study was approved and monitored by institutional review board of show chwan memorial hospital.


Eligibility criteria:
inclusion criteria: * in-patient persons with the pressure ulcer or diabetic ulcer exclusion criteria: * patient who has uncontrolled medical condition, such as sepsis, cellulitis * patient with diabetic ulcer who has severe paod untreated

Keywords: npwt foam gauze
vacuum assisted therapy in emergent contaminated abdominal surgeries

Conditions: Gastrointestinal Injury; Complicated Diverticulitis

Summary: emergent abdominal surgeries have very high rate of wound contamination due to exposure to bacteria from gi tract. there are several different approaches to wound management in these patients including wet-to-dry dressing or application vacuum assisted device on the wound. the investigators propose using the vacuum assisted device with dakin's solution on patients undergoing emergency surgery for hollow viscus perforation installed immediately at the end of operation and remained there for the first 3 postoperative days, followed by delayed primary closure on postoperative day 4. the investigators believe this technique can achieve earlier wound closure, decrease patient discomfort, improve cost savings, and potentially standardize and revolutionize the investigators management of heavily contaminated wounds.


Eligibility criteria:
inclusion criteria: * emergent surgery involving hollow viscus perforation or necrotic bowel * admitted to the university of arizona medical center, tucson, az exclusion criteria: * prisoners * pregnancy * patients with allergy to dakin's (sodium hypochlorite) solution.
iit-2022-simultaneous urolift™ and median lobe enucleation

Conditions: Benign Prostatic Hyperplasia

Summary: to evaluate postoperative outcomes of bph/lower urinary tract symptoms, erectile function, and ejaculatory capacity of simultaneous urolifttm and holmium laser enucleation of the prostatic median lobe.

preserving ejaculation is a significant factor that impacts patient's decisions regarding what proceeding with treatment of bph symptoms. the urolifttm system provides a safe procedure that has proven preservation of ejaculatory function. however, it is contraindicated in patients with prominent median lobes. the combination with laser median lobe enucleation may provide the same improvement in symptoms and widen patient inclusion criteria to those desire preserved ejaculation that also have a prominent median lobe.

Eligibility criteria:
inclusion criteria: 1. patients must be 45 years of age or older 2. patients must be diagnosed with benign prostatic hyperplasia 3. patients must opt for surgical management of their bph with desire for preservation of ejaculatory function 4. prominent median lobe with at least grade i intravesical protrusion of median lobe visualized on pre-operative cystoscopy exclusion criteria: 1. patients with baseline erectile and ejaculatory dysfunction as determined by a baseline iief-5 score \< 15 2. patients with a concomitant neurogenic bladder diagnosis (sci, parkinson, ms, cerebral palsy) 3. patients with prostate glands greater or equal to 100 grams 4. patients with less than a grade i intravesical protrusion of median lobe on pre-operative cystoscopy 5. patients who are enrolled in other surgical or interventional trials at the time of this study are not eligible.

Keywords: bph
comparison of clipping via keyhole versus traditional approaches and coiling for ruptured aneurysms

Conditions: Randomized Controlled Trial; Intracranial Aneurysm; Microsurgery; Endovascular Procedures

Summary: endovascular coiling has become a strategy of choice of intracranial aneurysms due to its minimally invasiveness. however, there has few prospective randomized controlled studies on the comparison of therapeutic effect between endovascular coiling and microsurgical clipping, especially the latter via keyhole approaches, which has been widely used in recent years. based on the data of a single center, a randomized controlled study was conducted on patients with ruptured anterior circulation aneurysms suitable for both endovascular and extravascular treatment, including endovascular coiling, microsurgical clipping via conventional craniotomy and keyhole approaches, in order to compare the efficacy of the above strategies and provide more objective basis for treatment selection for operators.

consecutive patients of a single center will be screened. if spontaneous subarachnoid hemorrhage (sah) is confirmed by head computed tomography (ct), a diagnostic ct angiography (cta) or digital subtraction angiography (dsa) will be carried out emergently. a patients harbored a single intracranial aneurysm of anterior circulation that resulted in sah will be concerned. based on the assessment of condition, the patient will enrolled into this study without indication of decompressive craniectomy. the enrolled patients will be divided randomly into 3 groups, who experienced endovascular coiling, microsurgical clipping via conventional craniotomy and via keyhole approaches. all of these treatment will be conducted by a same senior neurosurgeon. cta or dsa were followed up regularly. the occlusion rate, operative period, hospitalization duration and cost, surgical complications were compared and analyzed.

Eligibility criteria:
inclusion criteria: * single intracranial anterior circulation aneurysm diagnosed by cta or dsa * ct showed that subarachnoid hemorrhage originated from the rupture of the aneurysm and was confirmed during operation * no indication of decompressive craniectomy (hunt-hess grade ≤ 4, glasgow coma scale ≥ 7, no brain herniation; ct showed midline displacement \< 5mm) * the aneurysm is suitable for both endovascular treatment and microsurgical clipping exclusion criteria: * the patients and their families did not agree to join the study * patients with unruptured anterior circulation aneurysms * patients with posterior circulation aneurysms * patients with multiple intracranial aneurysms * those who cannot receive treatment due to serious concomitant diseases
the use of acupuncture for treatment of chemotherapy-induced peripheral neuropathy (cipn).

Conditions: Neoplasm; Adult Disease; Neuropathy

Summary: this study aims to determine the effectiveness of the use of acupuncture in relieving sensory and motor symptoms as well as functional impairment and quality of life of patients with chemotherapy induced peripheral neuropathy

the trial is a clinical, single-center, randomized trial study that will involve 30 adult cancer patients with chemotherapy-induced peripheral neuropathy randomized into two groups (control and acupuncture treated with 10 sessions, 2x per week). both cipn patients groups will be submitted to a complete physical examination and to clinical assessments with national cancer institute common terminology criteria for adverse events scale version 2.0, functional independence measure scale, european organisation for the research and treatment of cancer quality of life questionnaire core 30 scale and visual analogue scale for pain before treatment and in 5 weeks of follow-up after treatment.

Eligibility criteria:
inclusion criteria: cancer adult patients with cipn - exclusion criteria: other neuropathy -
drug interaction study between linezolid and clarithromycin in tuberculosis patients

Conditions: Multidrug-resistant Tuberculosis; Extensively Drug-resistant Tuberculosis

Summary: future patients might benefit from a combination of linezolid (lin) and clarithromycin (cla) in the treatment of multidrug-resistant and extensively drug-resistant tuberculosis (mdr/xdr-tb) due to possible synergistic activity as shown in in vitro experiments in different mycobacteria strains. the investigators observed increased lin serum levels in three cases after combining lin and cla of which the investigators described one in a case report (bolhuis et al). the investigators suggest to conduct a prospective pharmacokinetic study in mdr- and xdr-tb patients to quantify the above described interaction between lin and cla.


Eligibility criteria:
inclusion criteria: * age ≥18 years old * signed informed consent * diagnosis of mdr/xdr-tb confirmed with standard microbiological criteria (culture-based, molecular or both) * treatment with linezolid 300mg twice daily per os. exclusion criteria: * hypersensitivity to: linezolid, clarithromycin, erythromycin, or any macrolide antibiotics, or any of the excipients of linezolid or clarithromycin. * concomitant use with astemizole, cisapride, ergotamine derivatives (dihydroergotamine, ergotamine), monoamine oxidase inhibitors (phenelzine, isocarboxazid, selegiline, or moclobemide), pimozide, or terfenadine. * pregnancy or breast-feeding. * hypokalemia * concomitant use of other p-gp inhibitors/inducers, e.g. amiodarone, verapamil, digoxin, tipranavir/ritonavir, lovastatin, tariquidar, itraconazole, dipyridamol, erythromycin, ritonavir, quinidine.

Keywords: pharmacokinetic drug-interaction linezolid clarithromycin mycobacterium tuberculosis
face to face vs. group training methods on pulse rate taking in patients with cardiovascular diseases.

Conditions: Arrythmia

Summary: the aim of this study is to compare the efficacy of group training using a tutorial film and one-to-one face-to-face training in calculating the pulse rate and detecting irregularity in the pulse rhythm in patients with cardiovascular diseases.

pulse rate self-examination can provide a fairly good assessment of the patient's condition and helps the physician with drug dosage adjustment in patients with cardiac problems. this study will be conducted in the cardiology wards of modarres and loghman hospitals in tehran. these are two educational general referral hospitals of shahid beheshti university of medical sciences covering northern and southern part of tehran, the capital of iran respectively. after obtaining a written consent the patients will randomly assign into two groups using random number table. one group will receive a 20-minute face-to-face training session by a nurse on how to calculate the pulse rate in a minute and detect irregularities in the pulse rhythm whereas a 10-minute tutorial film with the same content will be shown to the other group. three practical test sessions are arranged for each patient, before the training session, right after the training session and at least 48 hours after the training session. the tests contain two parts and evaluate the patients' ability in calculating the exact pulse rate in a minute and detecting irregularities in the pulse rhythm. a special data-collecting questionnaire is designed for this study. this questionnaire contains background information such as sex, age, and literacy level as well as the practical test results. data gathering process will be performed by nurses in these hospitals. nurses, who participate in this study, will attend in briefing sessions on how to fill the data-collecting questionnaires. the sample size consists of 300 patients who admitted in cardiology ward (200 in modarres hospital and 100 in loghman hospital). the data will be inserted to the computer and the variables will be compared within and between groups using spss software version 16.

Eligibility criteria:
inclusion criteria: * patients admitted in cardiology ward * literacy (ability to read and write) exclusion criteria: -

Keywords: pulse rate patient education training
comparing x-3 to n2vac polyethylene with the triathlon total knee system

Conditions: Osteoarthritis; OA

Summary: methodology: this study will be a randomized, multi-center evaluation comparing n2vac polyethylene inserts and patellas with x3 inserts and patellas when used in the triathlon ps total knee system. study duration: 12-18 month enrollment period + 10 year follow-up for each case years total duration multi-centre study objectives primary: to compare the 10 year implant survival of the triathlon ps total knee system when x3 polyethylene components are used to the same knee system when n2vac components are used. secondary: to compare pain, function, radiographic outcomes, and health related quality of life of subjects in both treatment groups. safety will be assessed by comparison of adverse events between the groups. number of subjects 384 cases (197 each group)


Eligibility criteria:
inclusion criteria: * the subject requires a primary cemented total knee replacement. * the subject has a diagnosis of osteoarthritis (oa), traumatic arthritis (ta), or avascular necrosis (avn). * the subject has intact collateral ligaments. * the subject has signed the ethic committee approved, study specific informed patient consent form. * the subject is willing and able to comply with post-operative scheduled clinical and radiographic evaluations and rehabilitation. exclusion criteria: * the subject has inflammatory arthritis. * the subject is morbidly obese, bmi \> 40. * the subject has a history of total or unicompartmental reconstruction of the affected joint. * the subject has had a high tibial osteotomy or femoral osteotomy. * the subject has a neuromuscular or neurosensory deficiency, that would limit the ability to assess the performance of the device. * the subject has a systemic or metabolic disorder leading to progressive bone deterioration. * the subject is immunologically suppressed, or receiving chronic steroids (\>30 days duration). * the subject's bone stock is compromised by disease or infection and cannot provide adequate support and/or fixation to the prosthesis. * the subject has had a knee fusion at the affected joint. * the subject has an active or suspected latent infection in or about the knee joint. * the subject is a prisoner.

Keywords: osteoarthritis knee total knee arthroplasty gonarthrrsis polyethylene posterior stabilized
total hip arthroplasty and physical activity in patients younger than 50 years

Conditions: Hip Osteoarthritis; Physical Inactivity

Summary: rationale: tha is a widely applied procedure for osteoarthritis of the hip. after tha, one can expect an increase in physical activity due to the reduction of pain and increased range of motion of the hip joint, especially in young patients who in general have more active lifestyles. however, these young patients and their doctors don't know which increase in physical activity can be expected. objective: to measure the difference in physical activity before and after tha. study design: longitudinal prospective single center observational study. study population: 87 patients who have primary tha under the age of 50 years. excluding patients with an underlying oncologic disease which results in tha. intervention: n.a. main study parameters/endpoints: the first primary endpoint is physical activity in minutes per day. the other primary endpoint is mvpa in minutes per day. secondary endpoints are difference of tug outcomes in seconds and the difference of 6mwt outcomes in meters. for the patients experience, the copm total scores and nrs pain scores will be measured. nature and extent of the burden and risks associated with participation, benefit and group relatedness: this study requires three outpatient clinic visits. these visits will coincide with regular outpatient clinic visits, so patients will not have to come in extra for this study. during the preoperative and 1 year postoperative visit, the patients will complete the copm. the patient will wear a pa monitor for 7 days after each visit. patients might experience confronting feelings while being exposed to their pa activity profile after the study or experience mild discomfort while wearing the pa monitor since it will be worn 24 hours per day for 7 days. also, filling in the questionnaires will take some time (5-10 minutes per questionnaire series). there are no significant physical risks associated to this study.


Eligibility criteria:
inclusion criteria: * the age of the patient is between 16 and 50 years. * the patient has an indication for primary tha. exclusion criteria: * patients with an underlying oncologic disease which results in tha. * patients who are not able to walk.
in-depth analysis of the immune responses in the upper respiratory tract of influenza-infected children

Conditions: Influenza Infection

Summary: the noseflu-kids project aims at characterizing the immune response in the upper respiratory tract in children aged 2 to 5 with a laboratory-confirmed influenza infection. the immune response during the acute phase of the infection and after recovery will be compared to that of control children with no infection or vaccinated with the inactivated flu vaccine by the nasal route (recruited as part of a mirror study in oxford). the primary objective of this observational study is to quantify the inflammatory response in the nasal cavity and to correlate it with viral load and with clinical parameters. the study also aims to compare the inflammatory response measured in the nose to that measured in the blood. participants will have two study visits including a blood draw, several nasal samplings (nasal lining fluid and nasal cells) and a saliva sampling, one within 72 hours of their hospital admission and another one month later. nasal lining fluid and saliva will be obtained every two or three days until symptoms disappear. during those visits, questions regarding symptoms will be asked.


Eligibility criteria:
inclusion criteria: * aged 2-5 years * presenting clinical signs of an influenza-like illness * having a concomitant positive laboratory test for influenza. exclusion criteria: * immunosuppression * intubation or under invasive mechanical ventilation * co-infection with rsv or sars-cov-2