Kornimate/medical-research-clean huggingface dataset:
the level of patient participation in lung and esophageal cancer patients treated with definitive radiochemotherapy.

Conditions: Lung Cancer; Esophageal Cancer

Summary: this study aims to assess the level of participation of thoracic cancer patients undergoing definitive radiotherapy and chemotherapy ± immunotherapy in their medical processes and the association between the level of participation and patients' side effects, quality of life, and long-term survival. additionally, this study will rate the level of participation from both the patients' and medical staff's perspectives and will compare the differences in ratings from these two viewpoints, as well as their impact on treatment outcomes.


Eligibility criteria:
inclusion criteria: * locally advanced non-small cell lung cancer, limited-stage small cell lung cancer, and esophageal cancer. * planned to undergo definitive chemoradiotherapy ± immunotherapy; * males or females aged 18 to 75; * able to communicate with medical staff. exclusion criteria: patients with cognitive impairments.
dose response to recombinant factor viia when administered for bleed

Conditions: Congenital Bleeding Disorder; Healthy

Summary: this trial is conducted in the united states of america (usa). the purpose of this trial is to investigate the dose response to recombinant factor viia in healthy volunteers when administered for bleed.


Eligibility criteria:
inclusion criteria: * ages eligible for study: 18 years - 60 years exclusion criteria: * - -

Keywords: rfviia punch biopsy dose response healthy people programs
ultrasound guided erector spinae plane block versus quadratus lumborum block for postoperative analgesia in patients undergoing laparoscopic sleeve gastrectomy

Conditions: Post Operative Pain

Summary: postoperative pain control is a signiﬁcant challenge in medical practice. inadequate pain control could decrease patient's satisfaction, delay postoperative ambulation, increase the incidence of pulmonary and cardiac complications and cause the development of chronic postoperative pain. laparoscopic surgical techniques could decrease postoperative pain and opioid consumption. the addition of regional techniques to general anesthesia showed better pain management and less consumption of opioids compared to the traditional techniques. the aim of this study is to compare the effectiveness of ultrasound guided erector spinae plane block versus quadratus lumborum block regarding postoperative analgesia in patients undergoing laparoscopic sleeve gastrectomy.


Eligibility criteria:
inclusion criteria: * patients with free medical history or controlled hypertension and/ or diabetes scheduled for elective laparoscopic sleeve gastrectomy. * bmi \> 35 kg/ m2 exclusion criteria: * patients unfit for surgery or refuse to sign the consent of regional block. * patients with known coagulation defects. * patients with known hypersensitivity to bupivacaine. * patients with infection at the site of injection. * conversion of laparoscopic surgery to laparotomy
longitudinal evolution of biomarkers of dysautonomia and inflammation during sepsis in children

Conditions: Sepsis; Autonomic Nervous System

Summary: the autonomic nervous system (ans) regulates the inflammatory response in real time, just as it controls heart rate and other vital functions. many studies have investigated induced stimulation of the vagus nerve and its therapeutic effect in inhibiting tnfα (tumor necrosis factor alpha) secretion, and therefore the risk of hypotension, septic shock, organ dysfunction during inflammation. while the anti-inflammatory effect of the autonomic nervous system on inflammation has been well studied, conversely, the effect of major inflammation on the balance of the autonomic nervous system is more difficult to understand. the inflammatory reflex could be overwhelmed and the regulatory centers of the brainstem dysregulated during situations of extreme inflammation.

the purpose of this study is to follow the short-term evolution of sympathetic and parasympathetic markers of dysautonomia in children hospitalized in intensive care units for severe sepsis, to characterize the evolution of the different autonomic indices according to the site of infection (meningitis, pulmonary infection, organ failure, bacteraemia) and types of pathogens (viral, bacterial, atypical germs) and correlating the evolution of the various inflammation biomarkers and cytokines with the degree of dysautonomia.

Eligibility criteria:
inclusion criteria for cases group : * hospitalization in a pediatric intensive care unit. * presenting the sepsis criteria * patient affiliated or entitled to a social security scheme * holders of parental authority having received informed information about the study and having signed the consent form exclusion criteria for cases group : * parents or legal guardians who do not speak french * chronic or acute pathology that can alter autonomic balance (congenital heart disease, encephalopathy, neuropathy, acute pain, etc.) * recent general anesthesia less than 48 hours old. (inclusion may be made beyond 48 hours from the last general anesthesia if the inclusion criteria remain present) * taking treatments that can alter the ans (β-blockers, etc.) or inflammation (nsaids, corticosteroids) inclusion criteria for control group : * patient affiliated or entitled to a social security scheme * holders of parental authority having received informed information about the study and having signed the consent form exclusion criteria for control group : * parents or legal guardians who do not speak french * chronic or acute pathology that can alter autonomic balance (congenital heart disease, encephalopathy, neuropathy, acute pain, etc.) * recent general anesthesia less than 1 month. * taking treatments that can alter the ans (β-blockers, etc.) or inflammation (nsaids, corticosteroids)

Keywords: dysautonomia
lumbar kinematics in people with the low back pain

Conditions: Lumbar Disc Herniation; Protrusion; Extrusion of Migrated Disc; Hernia

Summary: this study evaluates the effect of lumbar disc herniation on kinematics in the lumbopelvic region during daily living activities.

lumbar disc herniation (ldh) is one of the causes of low back pain and contributes to increasing the socio-economic problem. depending on the reason for the dysfunction, various classifications describing the level of advancement are used. the literature on the subject commonly uses the division into protrusion and extrusion of the intervertebral disc, as approved by the american society of neuroradiology. the lumbopelvic kinematics, including gait and daily living activities, can be affected by the ldh: protrusion or extrusion. this pathology may be different due to the direction of disc migration: centre, left, right or all mentioned. therefore, we believe that from the different direction of the disc migration the different symptoms can be observed.

Eligibility criteria:
inclusion criteria: * disc disease located in the lumbar region of the spine confirmed in the mri * subacute stage of the disease * age 18-35 years exclusion criteria: * advanced degenerative-deformation changes of the spine * previous fracture of the spine * neurologic deficits in lower limbs or pelvis * spondylolisthesis * transitional vertebra * rheumatic diseases

Keywords: degenerative disc disease protrusion extrusion gait kinematics
prospective multicenter registry of hybrid coronary artery revascularization combined with surgical bypass and percutaneous coronary intervention using everolimus eluting metallic stents

Conditions: Coronary Artery Disease

Summary: this prospective multicenter registry evaluates the efficacy of hybrid coronary revascularization (hcr) combining coronary artery bypass surgery (cabg) and percutaneous coronary intervention (pci) in the treatment of multivessel coronary artery disease. cabg is to be performed in the left anterior descending artery and the left circumflex artery using only arterial grafts, whereas pci is to be conducted for the treatment of significant stenotic disease in the right coronary artery with everolimus-eluting stents (eess). this research plans to involve patients scheduled for coronary revascularization for multivessel coronary artery disease who consent to participate in the registry.


Eligibility criteria:
inclusion criteria: * patients with stable angina, unstable angina, or non-st elevation myocardial infarction. * patients with multivessel coronary artery disease including significant stenotic lesion\* in the right coronary artery and also including left main stem disease. * patients who will be referred for cabg. * patients with significant stenotic lesion in the right coronary artery amenable to pci. * patients who can take dapt medications. * patients who provided written informed consent. \* significant stenotic lesion means a condition where fractional flow reserve (ffr) is lower than 0.80 or visually confirmed stenosis is at least 75%. exclusion criteria: * • patients with st elevation myocardial infarction occurring within 24 hours before enrollment. * patients who previously underwent cabg. * patients who are at high risk of receiving cabg. * patients who need simultaneous surgery such as valve surgery other than cabg. * patients with a life expectancy of 1 year or shorter due to co-morbidities. * patients with a history of cerebral infarction within the last 6 months. * patients with congestive cardiac failure of nyha 3 or higher. * patients with unstable hemodynamics at enrollment. * patients with right coronary artery disease that is chronic total occlusion and difficult to treat with pci (j-cto score of ≥ 23). * patients receiving long-term dialysis. * patients who are allergic to antiplatelet agent. * patients who are critically allergic to contrast media. * patients who are allergic to any des component.
autologous muscle derived stem cells transplantation in urine incontinency

Conditions: Stress Incontinency

Summary: this study was designed to provide confirmation of safety of muscle derived cell (mdcs) for the treatment of stress urine incontinency (sui) in women.

the investigators will be assessed the 12-month safety and potential efficacy of autologous muscle derived cells as therapy for stress urinary incontinence. a total of 10 women in whom stress urinary incontinence had not improved underwent intra-sphincter injection of low doses 30×106 of autologous muscle derived cells, which will be derived from biopsies of their deltoid muscle. assessments will be made at 1, 3, 6 and 12 months after cell injection. changes in stress urinary incontinence severity were evaluated by pad test, diary of incontinence episodes and quality of life surveys.

Eligibility criteria:
inclusion criteria: * female * stress urinary incontinence symptoms * urodynamic stress incontinence confirmed with multichannel urodynamic testing * positive cough stress test * urgency score \< stress score * patient's age between 40 - 65 years * desire to surgical correction of stress urinary incontinence or inadequate response to conservative treatment of sui exclusion criteria: * post-void residual volume \>100cc * detrusor overactivity on preoperative multichannel urodynamic testing * history of previous synthetic, biologic or fascial sub-urethral sling or any other surgery on external genitalia, bladder neck, bladder or urethra * desires future childbearing * chronic inguinal or vulvar abscess or history of hidradenitis suppurative * history of bleeding diathesis or current anti-coagulation therapy * inguinal lymphadenopathy or inguinal/vulvar mass * current genitourinary fistula or urethral diverticulum * current sever cystocele or rectocele * active urinary infection * non-treated urge incontinency or any significant voiding dysfunction * neuromuscular disorders * uncontrolled diabetes * reversible cause of incontinence (i.e. drug effect) * contraindications for surgery

Keywords: transplantation autologous stress urinary incontinence muscle derived cells
liposomal vs. conventional bupivacaine for pain control

Conditions: Local Anesthetics; Analgesia; Regional Block; Paravertebral Block

Summary: the goal of this pilot study is to test the hypothesis that liposomal bupivacaine extends the duration of paravertebral block in patients undergoing radical nephrectomy, achieving improved analgesia compared to conventional bupivacaine. the main questions it aims to answer are: * area under curve of numeric rating scale of pain from 12 to 72 h after surgery. * cumulative opioid consumption during the period of 12 to 72 h after surgery.

random numbers will be generated by an independent biostatistician in a 1:1 ratio, sealed in sequentially numbered opaque envelopes, and stored by a study coordinator. only anesthesiologists who perform paravertebral block know group allocation but are not involved in other parts of the trial. patients, other health-care team members, and investigators for data collection and outcome assessment are masked from group assignments. paravertebral block will be performed with either liposomal bupivacaine or plain bupivacaine. the efficacy of nerve block will be assessed every 5 minutes after local anesthetic injection. we will evaluate pain severity, opioid consumption, and occurrence of adverse events at the following timepoints, i.e., end of surgery, 30 minutes after surgery, and 2, 6, 12, 24, 36, 48, 60, and 72 hours after surgery. additionally, occurrence of complications, quality of recovery, and subjective sleep quality will be assessed during hospital stay after surgery.

Eligibility criteria:
inclusion criteria: * age between 18 and 70 years old. * scheduled for laparoscopic-assisted unilateral radical nephrectomy. * agree to undergo regional nerve blockade and receive patient-controlled intravenous analgesia after surgery. exclusion criteria: * renal cancer with venous thrombus of grade ii or higher, or cases that may convert to open surgery. * body mass index ≥30 kg/m² or ≤15 kg/m². * severe renal dysfunction (serum creatinine \>442 μmol/l or requiring renal replacement therapy), severe liver dysfunction (child-pugh class c), or american society of anesthesiologists class ≥iv. * contraindications for deep nerve block, including severe spinal deformity or history of spinal surgery, severe coagulation abnormalities (international normalized ratio \>1.7, activated partial thromboplastin time \>4 seconds above normal, platelet count \<80×10⁹/l), trauma or infection at the planned puncture site, or severe lumbar back pain. * chronic opioid dependence and long-term use of various analgesics for more than 3 months. * preoperative inability to communicate due to severe dementia, language barriers, or end-stage diseases. * preoperative concomitant central nervous system and/or peripheral nervous system diseases. * planned endotracheal intubation and admission to the intensive care unit after surgery. * known allergy to local anesthetics. * other conditions that are deemed unsuitable for trial participation by the attending surgeons or investigators.

Keywords: liposomal bupivacaine paravertebral block postoperative pain nephrectomy
internet-based self-help for negative life events

Conditions: Adjustment Disorders

Summary: the purpose of the study is to investigate the efficacy of an internet-based self-help intervention for dealing with stressful life events.

the purpose of the study is to investigate the efficacy of an internet-based self-help intervention for dealing with stressful life events compared to a waiting list, in a randomized controlled trial design. assessments are at baseline, 4-week and 3 months post-randomization. after 4 weeks, participants in the waiting control group get also access to the intervention.

Eligibility criteria:
inclusion criteria: * negative life event in a period between two weeks and two years before the study * internet account * sufficient german language skills * informed consent exclusion criteria: * persons with moderate or severe depressive symptoms * acute suicidality * psychotic disorder, bipolar disorder * severe, acute mental or physical disorder
early detection of cardiovascular disease

Conditions: Atheroma; Cardiac Disease; Vascular Diseases; Atherosclerosis; Myocardial Infarction; Acute Coronary Syndrome

Summary: the investigators plan to evaluate the correlation between carotid plaque enhancement on contrast-enhanced ultrasound (ceus), significant coronary artery disease (cad), and cardiovascular (cv) outcomes in a systematic manner. the investigators hypothesize that increased levels of ceus-detected vulnerable carotid plaque will be predictive of cv risk determined by angiography and future cardiovascular events.

study design: the investigators will conduct a prospective, single-center, observational study at the cardiovascular imaging network at queen's (cinq, www.cinqlab.com). this facility allows a ceus protocol to be conducted on the same day as the angiogram. it is anticipated that 100 participants can be recruited per month with a total target enrolment of up to 1000 participants. objectives 1. to determine the test characteristics (sensitivity, specificity, negative/positive predictive values) of carotid plaque by ceus (definity(r)) for predicting significant cad (≥50% stenosis) in participants referred for angiography 2. to determine the test characteristics (sensitivity, specificity, predictive values) of carotid plaque by ceus for predicting future cv events, such as death, stroke, myocardial infarction, and cardiovascular interventions.

Eligibility criteria:
inclusion criteria: 1. \>18 years of age 2. outpatients referred for clinically indicated angiography for assessment of cad 3. low - intermediate framingham risk (\<20%) 4. absence of clinical contraindication to angiography 5. able and willing to give informed consent exclusion criteria: 1. patients presenting with acute coronary syndrome 2. patients with previously known significant cad (any lesion \>50%) or percutaneous coronary intervention or coronary artery bypass surgery 3. previous carotid surgery or angioplasty 4. documented allergy to echo contrast
sequential therapy versus quadruple therapy in h. pylori eradication

Conditions: Helicobacter

Summary: the investigators aimed to 1. compare the eradication rates and long term re-infection rates of sequential therapy for 14 days versus bismuth quadruple therapy for 10 days in the first line and second line treatment 2. assess the impact of antibiotic resistance and cyp2c19 polymorphism on the eradication rate of these regimens 3. assess the impact of these eradication regimens on the antibiotic resistance and microbiota of the gut flora 4. assess the impact of eradication therapy on the metabolic factors

helicobacter pylori infection has been shown to be associated with the development of gastric cancer and peptic ulcer diseases. eradication of h. pylori infection reduces the risk of gastric cancer and recurrence of peptic ulcer disease. however, the eradication rate of clarithromycin-based triple therapy has been declining in recent years, probably related to the increasing resistant rate to clarithromycin. sequential therapy for 10 days has been shown to be more effective than triple therapy for 7 and 10 days. the investigators further demonstrated that sequential therapy given for 14 days was superior to triple therapy given for 14 days. recently, the investigators also found that bismuth quadruple therapy given for 10 days appeared to be more effective than triple therapy given for 14 days in the first line therapy. however, whether sequential therapy given for 14 days is more effective than bismuth quadruple therapy or triple therapy for 14 days remains unknown.

Eligibility criteria:
inclusion criteria: 1. h. pylori infected patients naïve to eradication therapies will be eligible in this study. exclusion criteria: 1. children and teenagers aged less than 20 years, 2. history of gastrectomy, 3. gastric malignancy, including adenocarcinoma and lymphoma, 4. previous allergic reaction to antibiotics (bismuth, amoxicillin, metronidazole, clarithromycin, tetracycline) and ppi (esomeprazole), 5. contraindication to treatment drugs, 6. pregnant or lactating women, 7. severe concurrent disease, 8. concomitant use of clopidogrel, or (9) unwilling to accept random assignment of subjects

Keywords: efficacy safety h. pylori eradication
evaluation of the accuracy of full digital workflow for guided implant surgery using the r2 gate software

Conditions: Partially Edentulous Maxilla; Partially Edentulous Mandible

Summary: the primary aim of the present study is to compare the accuracy of a full digital workflow for dental implants insertion to a partially digital workflow, for a limited edentulous space (1 to 3 dental units), in the maxilla or mandible.

improvements of dental digital technologies are nowadays enabling clinicians to take the digital impressions of the dental arches, therefore avoiding the use of conventional impression materials. digital impression procedures are claimed to be an approach to improve the accuracy of dental restorations by minimizing the error prone to conventional impression and gypsum model casting, enabling a high degree of standardization. patients often prefer intraoral scan when compared to the traditional impression. digital impression is also recommended when patients have remaining teeth that are extremely mobile or misaligned, due to the risk of exfoliation during the conventional impression procedure. despite its poor scientific and clinical evidence, the use of digital technologies into the daily practice registers a rapidly growing. the precision of digital impressions depends on two different parameters: the resolution of the optical scanning system, and the precision of the matching algorithm which may significantly influence the precision of full arch scans. in order to minimize the effect of matching artifacts, only small parts of the dental arch in close vicinity of the teeth are recommended to be scanned. for prosthetic restoration purpose, several studies regarding the accuracy of digital vs analogue impression have been performed, but none comparing the accuracy of digital vs partially digital workflow for prosthetically driven guided dental implant insertion.

Eligibility criteria:
inclusion criteria: * kennedy class iii partially edentulism with 3 or less missing teeth, * good general health with no contraindications for implant surgery, * acceptance of dental implant treatment, * acceptance of 1 or 2 cbcts. exclusion criteria: * limited bone volume with stadial bone graft requirement, * limited mouth opening (impossible to use the surgical stent), * parkinson disease (impossible to perform an accurate cbct).

Keywords: dental implants digital workflow guided surgery