Kornimate/medical-research-clean huggingface dataset:
a survey to elicit the relationship between literacy and glycemic control in pediatric diabetes

Conditions: Diabetes; Type 1 Diabetes Mellitus; Type 2 Diabetes Mellitus

Summary: the purpose of this study is to see if a patient's ability (and/ or parent) to read, write, and do basic math problems affects blood sugar control in children with type 1 diabetes mellitus.

"literacy" is defined as an individual's ability to read, write, and speak english, and compute and solve problems at levels of proficiency necessary to function on the job and in society, to achieve one's goals, and develop one's knowledge and potential, according to the national literacy act of 1991. the national work group on health and literacy reported that between 40 and 44 million persons in the united states have rudimentary literacy skills, and are unable to understand written materials that require only basic reading proficiency. illiteracy has become an increasingly important problem, especially as it relates to healthcare. literacy skills are paramount to effective self-management of type 1 and type 2 diabetes mellitus. and, "diabetes self-management education" is the cornerstone of care for all individuals with diabetes who want to achieve successful health-related outcomes. self care of diabetes plays a major role in achieving dcct recommended level of hemoglobin a1c. deficient self-management will lead to uncontrolled diabetes, resulting in multisystem complications, increasing exponentially the burden on our healthcare system. structured education of individuals tailored to combat poor literacy skills is imperative in helping these individuals achieve good glycemic control. hence we would like to evaluate literacy in our clinic so appropriate educational material can be developed to help patient with t1dm who have low literacy.

Eligibility criteria:
inclusion criteria: * type 1 or type 2 diabetes mellitus * parent/ legal guardian must be present if child is less than 18 years of age. * diagnosis of type 1 or type 2 diabetes mellitus must have been made at least 1 year earlier. * parent/ legal guardian and/ or child must have completed all 3 mandatory diabetes education classes. * english and/or spanish speaking only. exclusion criteria: * any form of mental retardation or cognitive disorder in parent/ legal guardian. * mental retardation or cognitive disorder in a child who is in grade 6 or higher.

Keywords: diabetes type 1 diabetes mellitus type 2 diabetes mellitus literacy glycemic control
long-term impact of covid-19 restrictions on physical activity and social interactions in young adults

Conditions: COVID-19; Social Interaction; Physical Inactivity

Summary: there are studies on the impact of quarantine measures taken during the covid-19 pandemic on individuals' social interactions and physical activities. we think that the adaptation of individuals who have had covid-19 infection to return to social and physical activities after restrictions may affect participation in these activities. the aim of this study is to investigate the long-term impact of covid-19 restrictions on physical activity and social interaction in young adults, depending on whether they have had a covid-19 infection.

corona virus disease-19 was declared as a pandemic on 11 march 2020 by the world health organization. the fact that the measures taken to prevent the spread of the pandemic bring about a global quarantine process affects people's social interactions and physical activity levels with each other. the aim of this study is to investigate the long-term impact of covid-19 restrictions on physical activity and social interaction in young adults, depending on whether they have had a covid-19 infection. physical activity levels were assessed with the short form of the international physical activity questionnaire-short form. social interactions and social phobias are social interaction anxiety scale and social phobia scale were evaluated.

Eligibility criteria:
inclusion criteria: * young adults aged 18-25 * agreeing to participate in the study exclusion criteria: * having mental retardation

Keywords: covid-19 restrictions physical activity social interactions young adults
brief internet intervention for hazardous alcohol use

Conditions: Alcohol Consumption

Summary: amazon's mechanical turk (mturk) is an online platform that has become a popular means of recruiting participants with problem drinking, gambling, or even illicit drug use for the purposes of survey-based research. there is also the possibility that potential participants could be identified through mturk for online longitudinal studies, including for brief intervention research. the potential to quickly and easily identify large numbers of participants through mturk is important for research evaluating online interventions during the period that these interventions are being developed and refined. however, before proposing mturk workers as a viable source for participants in online intervention trials, it is important to evaluate the feasibility of using mturk for such a purpose. this pilot study proposes to test this feasibility by systematically replicating a trial of an extensively evaluated brief online intervention for hazardous alcohol use (checkyourdrinking; cyd) and will attempt to recruit and follow-up participants for this replication using people recruited through mturk. participants will be recruited through amazon's mturk crowdsourcing platform. participants identified as problem drinkers based on an initial survey will be invited to complete another survey in 3 months time. those who are interested will be randomized to receive access to the check your drinking screener (cyd condition) or to a no additional information condition (control condition). at three-months post-baseline, the mturk portal will be used to send invitation emails that contain a link to the follow-up survey. the primary hypothesis to be tested is that participants receiving access to the cyd intervention will report a greater level of reduction in number of drinks in a typical week between the baseline survey and three-month follow-up as compared to participants in the no information control condition.


Eligibility criteria:
inclusion criteria: * alcohol use disorders identification test (audit) score of 8 or more * willingness to complete a 3-month follow-up survey * 18 years of age or older
laparoscopic therapy of endometrioma: sclerotherapy vs cystectomy in patients with unfinished reproductive plans

Conditions: Endometrioma; Endometriosis

Summary: the aim of this prospective randomized study is to compare laparoscopic sclerotherapy to cystectomy in following: amh dynamics, endometrioma recurrence, complications, pregnancy rate, assisted reproduction methods success rate, live birth rate

only patients who sign informed consent will be included. only patients wishing for future pregnancy will be involved in the study. expected number of enrolled subjects is 160 ( 80 in each arm) patients with endometrioma and planned surgery to remove it will be randomized either to laparoscopic sclerotherapy with 96% ethanol or cystectomy. first amh sample will be taken day before surgery. if other endometriosis lesions (deep or superficial) are present, they may be also resected during this surgery. ethanol sclerotherapy description: classical laparoscopic approach - small (max1cm) fenestration of endometrioma - aspiration of endometrioma contents- foley catheter insertion- ballon inflation inside of the cyst- instillation with 96% ethanol which is left in the cyst for 10min- aspiration of ethanol and flushing with saline. cystectomy: classical laparoscopic approach- large fenestration of endometrioma - aspiration of endometrioma contents- indentification of ovary/ endometrioma tissue and plane between the ovarian capsule and cyst wall is developed using a mix of blunt and sharp dissection - if bleeding is present it is stopped by cautious bipolar coagulation visit 1 - surgery time (amh day before surgery, age, bmi, endometriosis extent, gravidity/ parity, endometriosis residue after surgery, pain levels) visit 2- 3 months after surgery : ultrasound, complications, pregnancy, asissted reproduction, pain levels visit 3+4 - 6/12months after surgery: amh, ultrasound, complications, pregnancy, asissted reproduction, pain levels visit 5- 24 months after surgery: ultrasound, complications, pregnancy, asissted reproduction, pain levels

Eligibility criteria:
inclusion criteria: * iota benign endometrioma * bilateral or unilateral endometrioma measuring 30 or more milimeters * patients with unfinished reproductive plans exclusion criteria: * bilateral recurrence of endometrioma * recurrent endometrioma if the other ovary is not present or patient had cystectomy on the other ovary * suspision for ovarian malignancy * signs of inflammatory pelvic disease * disagreement with participation in the study

Keywords: laparoscopic sclerotherapy endometrioma
preliminary study of safety and efficacy of policosanol

Conditions: Dyslipidemia; HIV Infections

Summary: lay language summary: high cholesterol levels are common in persons with hiv infection. however, conventional cholesterol-lowering medications may have harmful side effects when given to hiv-infected persons. therefore, we plan to evaluate the safety and effectiveness of policosanol, a dietary supplement derived from sugar cane that has cholesterol-lowering properties, to lower cholesterol levels in persons with hiv infection. we hypothesize that policosanol will lower levels of ldl cholesterol ("bad" cholesterol) and raise levels of hdl cholesterol ("good" cholesterol).

as per brief summary

Eligibility criteria:
inclusion criteria: cd4 count \> 250 plasma hiv rna \ 160 exclusion criteria: kidney or liver disease current use of lipid-lowering drugs pregnancy lactation -

Keywords: hiv lipids dyslipidemia policosanol treatment experienced
adding core stabilization training to manuel therapy in temporomandibular disorders

Conditions: Temporomandibular Disorders; Temporomandibular Joint Disorders

Summary: primary aim of this study is to determine whether core stabilization training in addition to orofacial manual therapy is more effective on temporomandibular disorders (tmd) symptoms than orofacial manual therapy alone in patients with tmd. these secondary aim is to determine the effectiveness of orofacial manual therapy on tmd symptoms in patients with tmd. patients will be treated for 10 sessions once a week, for a total of 10 weeks. evaluation was planned to be done twice, at the beginning and end of the treatment.

primary aim of this study is to determine whether core stabilization training in addition to orofacial manual therapy is more effective on temporomandibular disorders (tmd) symptoms than orofacial manual therapy alone in patients with tmd. these secondary aim is to determine the effectiveness of orofacial manual therapy on tmd symptoms in patients with tmd. the patients to be included in the study will be randomly divided into three groups and it is planned to include 15 people in each group. home exercises and patient education will be provided to all patients. * group 1 (cst group): orofacial manual therapy + core stabilization training (cst) + home exercise and patient education * group 2 (omt group): orofacial manual therapy (omt) + home exercise and patient education * group 3 (control group): home exercise and patient education. pain intensity, pressure pain threshold, joint range of motion, posture, flexibility, stabilization of core muscles, functionality and sleep quality will be evaluated by using visual analog scale (vas), digital algometer, ruler, palpation meter (palm), bubble inclinometer, tape measure, finger-to-floor distance (epzm) and sit-reach test, pressure biofeedback unit, "helkimo index", "pittsburgh sleep quality index (puki)" respectively. patients will be treated for 10 sessions once a week, for a total of 10 weeks. evaluation was planned to be done twice, at the beginning and end of the treatment.

Eligibility criteria:
inclusion criteria: * volunteered to participate, * aged between 18-60 years old, * having the diagnosis of temporomandibular disorders (tmb), exclusion criteria: * having a malignant condition, trauma and surgery of the cranial and cervical region, * not being cooperative, * regular use of analgesic and anti-inflammatory drugs, * having dentofacial anomalies, * having active inflammatory arthritis, * having lumbal pathology, * having metabolic diseases (gout, osteoporosis, cushing's disease and hyper/hypo-parathyroidism), * having connective tissue, rheumatological (systemic lupus erythematosus and scleroderma) and hematological disorders (anemia and leukemia), * having a diagnosed psychiatric illness, * receiving tmd-related physical therapy less than 6 months ago

Keywords: core stability exercise pain manuel therapies temporomandibular disorder
betrnet stem cells and the origins of barrett's esophagus project 3 rf ablation

Conditions: Barrett's Esophagus

Summary: the purpose of this study is to determine biomarkers which can predict response to ablation therapy in patients with barretts esophagus.

this project is designed to identify biologically-based and clinically-useful biomarkers of tissue at risk for neoplastic progression as well as of response to ablation therapy. these results will result in improved risk stratification in be and better targeting of resources for patients who are candidates for ablative therapy, while simultaneously providing key information regarding the origins of barrett's esophagus.

Eligibility criteria:
inclusion criteria: * barrett's esophagus with high grade dysplasia or intramucosal (early) adenocarcinoma. * be length ≥ 2 cm and ≤ 8 cm. * able to return every 3 months for one year after ablation exclusion criteria: * patients who are unable to be compliant with follow-up endoscopies * patients who cannot tolerate proton pump inhibitors * pre-existing esophageal strictures * pregnant or nursing women

Keywords: barrett's esophagus high grade dysplasia ablation radiofrequency ablation esophageal cancer
conditioning regimen before infusion of allogeneic hematopoietic stem cells

Conditions: HEMATOLOGIC MALIGNANCIES

Summary: unrelated donor hematopoietic stem cell transplantation after nonmyeloablative conditioning for younger patients with hematologic malignancies.

primary end points are treatment-related mortality and engraftment. secondary end points are regimen-related toxicities, graft-versus-host-disease, relapse, and overall survival.

Eligibility criteria:
inclusion criteria: -patients should have an unrelated donor who is matched for hla-a and -b by serology and for -drb1 by molecular typing. exclusion criteria: * patients should not have major illness or organ failure * patients must not have a psychiatric disorder or mental deficiency severe as to make compliance with the treatment unlike, and making informed consent impossible. * patients must not be pregnant or lactating.

Keywords: patients without comorbidity
bms-741672 for diabetic neuropathic pain

Conditions: Neuropathic Pain

Summary: the purpose of the study is to determine whether bms-741672 improves neuropathic pain in diabetic patients.


Eligibility criteria:
inclusion criteria: * type 1 or 2 diabetics with painful, distal, symmetrical, sensory-motor neuropathy attributed to diabetes, of at least 12 months duration * screening hba1c of ≥ 7% and ≤ 10% * bmi ≤ 40 kg/m2 exclusion criteria: * patients with clinically significant, progressive, or potentially unstable disease of any body system including cardiovascular, gastrointestinal, central nervous system (cns), psychiatric, endocrine (other than diabetes), tuberculosis or renal * women of childbearing potential
perioperative csf leak management - an opinion study

Conditions: Cerebrospinal Fluid Leak

Summary: cerebrospinal fluid (csf) leak is a rare condition. when it involves the ventral skull base, a surgical closure may be achieved using endoscopic skull base surgery techniques. the major principles remain in achieving a watertight closure that can also support the brain (and avoid brain sagging) in case of extensive skull base defects. surgical techniques are well described. many clinical factors may influence the successful rate of the reconstruction. however, there is a lack of clinical study on perioperative management of csf leaks. the purpose of this study is to gather the opinion of skull base surgeons on the post-operative management of patients to avoid csf leak recurrence. •methods: the investigators will collect data from skull base surgeons using an electronic survey questionnaire (google form, google, mountain view, california, u.s.a.) submitted by e-mail to the members of the french association of rhinology, to the european rhinologic society, to the french college of neurosurgeons, to the italian skull base society members, and to the former students of the european endoscopic skull base diploma. this is an anonymous 60-items survey. questions were classified in eight sections: general questions, material used at the end of the surgical procedure, post-operative resting position, drugs, csf depletion, post-operative advices, explorations in case of early recurrence of the rhinorrhoea, and follow-up modalities. •discussion: the investigators aim to understand the actual practice of skull base surgeons after closure of ventral skull base csf leaks. this can serve as a basis for conducting clinical studies in the future.


Eligibility criteria:
inclusion criteria an individual must fulfill all of the following criteria in order to be eligible for study enrollment: * active skull base surgery practice (ent surgeon or neurosurgeon) * volunteering non inclusion criteria * subject unable to read or/and write * undergraduate students * refusal to participate

Keywords: skull base surger csf leaks intracranial pressure endoscopic skull base surgery csf depletion ent surgeon or neurosurgeon
evaluating the efficacy, safety, pharmacokinetics, and pharmacodynamics of biib054 in participants with parkinson's disease

Conditions: Parkinson's Disease

Summary: the primary objective of the study is to evaluate the clinical efficacy of biib054 via dose response using the change from baseline in movement disorder society-unified parkinson's disease rating scale (mds-updrs) total score. the secondary objectives of the study are to evaluate the dose-related safety of biib054, to evaluate the clinical efficacy of biib054 via mds-updrs total score, to assess the pharmacokinetic (pk) profile of biib054, to evaluate the clinical efficacy of biib054 based on mds-updrs subparts, to evaluate the pharmacodynamic effects of biib054 on the integrity of nigrostriatal dopaminergic nerve terminals and to evaluate the immunogenicity of biib054.


Eligibility criteria:
inclusion criteria * diagnosed with parkinson's disease (pd) within a maximum of 3 years prior to screening. * score of ≤2.5 on the modified hoehn and yahr scale. * has not received any medication for the treatment of the motor symptoms of pd for at least 12 weeks prior to day 1 and, in the opinion of the investigator, is not expected to require pd treatment for at least 6 months following day 1. maximum total duration of prior pd regimens should not exceed 30 days. stable (at least 8 weeks) dosages of medications that are used to treat conditions other than pd tremor are allowed. further guidance will be provided by the study's medical monitor on a case by case basis. * screening dopamine transporter (dat)/ single-photon emission computed tomography (spect) results consistent with neurodegenerative parkinsonism (central reading). * all women of childbearing potential and all men must practice highly effective contraception during the study and for 6 months after their last dose of study treatment. exclusion criteria: * presence of freezing of gait. * montreal cognitive assessment (moca) score \<23 or other significant cognitive impairment or clinical dementia that, in the opinion of the investigator, would interfere with study evaluation. * history of or screening brain magnetic resonance imaging (mri) scan indicative of clinically significant abnormality, as read by central reader. * history of severe allergic or anaphylactic reactions, or history of hypersensitivity to biib054 or any of the inactive ingredients in the drug product or to radioligands or iodine used in the study. * participation in any active immunotherapy study targeting alpha-synuclein. * use of allowed medications not previously specified at doses that have not been stable for at least 8 weeks before day 1, and/or that are not expected to remain stable for the duration of the study. * clinically significant abnormal laboratory test values at screening, as determined by the investigator. * blood donation (1 unit or more) within 8 weeks before day 1 (must also refrain from donating blood for the duration of the study). note : other protocol defined inclusion/exclusion criteria may apply

Keywords: biib054 alpha-synuclein
implantable antenna sensors for continuous glucose monitoring

Conditions: Type 1 Diabetes Mellitus

Summary: the researchers' long-term goal is to develop a small implantable device that can continually monitor glucose levels. this will be an antenna. changes in the glucose levels in will affect the antenna signals and those can be used to predict the patient's glucose levels.

our goal is to develop a small size implantable device that can continually monitor glucose levels. the scientific objective of this application is to examine the efficacy of using implantable antennas to measure the glucose levels. the central hypothesis of this application is that the changes in the glucose levels in the medium surrounding the antenna will affect the antenna parameters such as input impedance and resonance frequency, and these changes can be used to predict the patient's glucose levels. we have formulated this hypothesis on the basis of our preliminary data, which will be detailed later, in the preliminary studies section. the rationale for the proposed research is that, once the correlation between the glucose levels and antenna parameters are determined, the design of a miniaturized long term glucose monitoring device will become a reality.

Eligibility criteria:
inclusion criteria: * healthy adult able to give a blood sample exclusion criteria: * adults with diabetes or other glycemic or hematologic disorders. * sick adults

Keywords: antenna continuous glucose monitoring electromagnetic