Kornimate/medical-research-clean huggingface dataset:
effect of owning a service dog on military veterans with ptsd

Conditions: Physiological Responses; Sleep Disorders, Circadian Rhythm; Stress, Emotional

Summary: the study aims to investigate the effects of a service dog on military veterans with post traumatic stress syndrome (ptsd). the investigators will use non-invasive measures of the physiological responses, data obtained via dairy keeping, accelerometer data estimating activity and sleep patterns, and baseline information including psychological measures validated for this specific population.

the investigators will measure and compare the immediate effect of the presence of the dog, on days with low stress and high stress, using non-invasive measures of the physiological response, diary notes, and data on activity and sleep pattern the latter will also be collected for the service dogs. the investigators will apply a cross-sectional design. the participants will be divided into two groups based on whether they own a certified service dog (treatment group) or are on a waitlist for a service dog (control group). the experimental period will consist of a 14-day period. in the preceding week the participants receive a visit, where they will be given instructions to fill in a diary, how to collect and store saliva samples, and use equipment for data collection. in the diary they record their daily activities and any situation perceived to be stressful during the experimental period. in the experimental period, the participants will wear an accelerometer. every second day, the particpants will wear equipment measuring their heart rate.

Eligibility criteria:
inclusion criteria: * have been deployed in a war zone * fulfil criteria for ptsd * fulfil criteria for receiving a certified service dog * if having a service dog, they must have owned the dog for more than 6 months, and the dog must be at leat 2 years of age exclusion criteria: * use of alcohol or drugs to an extent that it affects the ability to attend to ordinary daily activities

Keywords: human-animal contact non-invasive measure
lung recruitment improves right ventricle performance

Conditions: Atelectasis

Summary: this study test whether a lung recruitment maneuver improves the right ventricle performance after cardiopulmonary bypass. half of the patients received an standard protective ventilation and the other half the same ventilatory pattern after a lung recruitment maneuver.

atelectasis is developed in 90% of anesthetized patients after surgery. protective ventilation with low tidal volumes and positive-end expiratory pressure (peep) promotes atelectasis with the potential right ventricle dysfunction induced by the increment in afterload (activation of the pulmonary hypoxic vasocontriction reflex). lung recruitment can improve the right ventricle performance caused by atelectasis because the pulmonary hypoxic vasocontriction reflex desapear in a normal aerated lungs.

Eligibility criteria:
inclusion criteria: * cardiovascular surgery with cardiopulmonary bypass. * patients with a new york heart association (nyha) class i-ii, * pre-operative left ventricular ejection fraction ≥ 50 %. * euroscore ≤ 6. exclusion criteria: * tee contraindications. * hemodynamically unstable * needi for inotropic support
treat (telemedicine for reach, education, access, and treatment)

Conditions: Type 2 Diabetes

Summary: the purpose of this study is to evaluate the feasibility and clinical efficacy of an innovative care model that combines telemedicine consultations, educator therapeutic management and diabetes education to empower patients to be in greater control of their own diabetes care for improvements in diabetes outcomes.

this study will assess whether a new care delivery model combining telemedicine videoconference diabetes consultations with diabetes self-management teaching is efficacious in reducing hba1c in patients with type 2 diabetes in rural areas. the control group will consist of patients with type 2 diabetes receiving "usual care", i.e., who have not received a referral to the endocrinologist telemedicine team. secondary outcomes include patient satisfaction, level of understanding of self-management skills, and hypoglycemia

Eligibility criteria:
inclusion criteria: * age 18 or older with type 2 diabetes * referral by a primary care provider. * hba1c equal or greater than 7.0%. exclusion criteria: * type 1 diabetes * gestational diabetes

Keywords: type 2 diabetes
construct validity and intra-observer reliability of the sdq

Conditions: Cerebral Palsy

Summary: the aim of the observational study is to investigate the validity and reliability of a self-report version of the strength and difficulties questionnaire (sdq) for 11-17 years in children with cerebral palsy (cp). that is, the current study explore if the self-report version of the sdq would be valid and reliable in children with cp to report their mental health problems themself


Eligibility criteria:
inclusion criteria: * a diagnosis of cp, a communication level of i-iii on the communication function classification system (cfcs), and no severe intellectual disability exclusion criteria: * the presence of an inability to comprehend items on the sdq and involuntary attendance of a possible re-test after two weeks (i.e., for re-test reliability)

Keywords: cerebral palsy strength and difficulties questionnaire validity reliability
kinesio tape effects on ankle proprioception

Conditions: Sprains and Strains

Summary: the aim of the present study was to establish whether kinesio tape (kt) on the ankle (kase protocol for the lateral ankle ligament) improves joint position sense (jps) in healthy volunteers immediately after its application and 48 hours later.

the investigators assessed joint position sense (jps) through the difference of error (doe) and the deviation of the target angle (dta). jps was assessed before the kinesio tape (kt) was placed, immediately after and 48 hours later.

Eligibility criteria:
inclusion criteria: * must be signed the informed consent * aged between 18 and 35 years * did not suffered from ankle or foot skin diseases * active dorsal/plantarflexion arom equal to or above 15º and inversion/eversion * arom equal to or above 5º. exclusion criteria: * traumatic, neurological or circulatory diseases diagnosed * joint laxity * more than three ankle sprains in their lives or one in the last 12 months that required treatment and ankle or foot pain at the time of study enrolment in the non-dominant lower limb.

Keywords: ankle lateral ligament athletic tape position sense proprioception
a study to compare digital disease monitoring of patients with csu (telemedicine to face-to-face visits) in germany

Conditions: Chronic Spontaneous Urticaria

Summary: this is a multicenter, non-randomized, non-interventional two-cohort study with prospective collection of primary data on monitoring of chronic spontaneous urticaria (csu) patients by telemedicine or f2f visits in routine clinical care. this implementation science study will collect data from patients during routine csu monitoring via f2f visits or teledermatological visits. the study will be representative for the real-world patient csu population in germany.

this study will investigate the effect of digital monitoring via teledermatology on patient-reported outcomes (pro) usage in csu. the automatic provision of pros at each digital patient-physician contact will allow simple and time-efficient documentation of current symptoms and might improve patients care. this study seeks to assess the impact of regular teledermatology-based monitoring on the utilization frequency of pros in patients with csu, as compared to the in-person visits f2f. furthermore, the study aims to gauge the adaption, quality and assessibility of teledermatology of both health care providers and patients .

Eligibility criteria:
inclusion criteria: * adults aged 18 and above * written informed consent for participation obtained from the subject * diagnosed chronic spontaneous urticaria * medical therapy for csu * concomitant chronic inducible urticaria is allowed * willing and be able to perform digital visits exclusion criteria: • simultaneous participation in any clinical trial

Keywords: nis
intra-articular betamethasone and the hypothalamic-pituitary-adrenal axis

Conditions: Adrenal Suppression

Summary: to evaluate the effect of intra-articular corticosteroid injection (iaci) of depot preparation of betamethasone on the hypothalamic-pituitary-adrenal (hpa) axis, in patients with osteoarthritis of the knee

consecutive patients attending the rheumatology or orthopedic clinic with osteoarthritic knee pain, not responding satisfactorily to medical or physical therapy were allocated to group-1 after consent and given iaci of 6 mg of betamethasone acetate/betamethasone sodium phosphate. following completion of this part, consecutive age- and sex-matched patients were allocated to group-2 and given intra-articular injection of 60 mg of sodium hyaluronate. just prior to the knee injection and 1, 2, 3, 4 and 8 weeks later, patients had 1 µg adrenocorticotropin hormone (acth) stimulation test. secondary adrenal insufficiency (sai) was defined as levels of less than 18 ng/ml or a rise of \< than 7 ng/ml of serum cortisol, 30 minutes following the acth stimulation test.

Eligibility criteria:
inclusion criteria: * osteoarthritis of the knee exclusion criteria: * had steroids in the last 3 months. allergic to steroids
seizure prophylaxis with levetiracetam in aneurysmal subarachnoid hemorrhage - pilot study

Conditions: Subarachnoid Hemorrhage; Seizures

Summary: the purpose of this study is to determine the feasibility of prospectively enrolling and randomizing patients with aneurysmal subarachnoid hemorrhage (asah) to receive levetiracetam or not to receive levetiracetam, and documenting in-hospital and follow-up clinical variables.


Eligibility criteria:
inclusion criteria: * ≥ 18 years of age * ≤ 75 years of age * newly diagnosed aneurysmal subarachnoid hemorrhage exclusion criteria: * one or more antiepileptic medication is taken as a pre-admission medication * seizure occurrence in the field or in the emergency department, or anytime before consent could be obtained * inability to obtain informed consent from the patient, or from the patient's appropriate surrogate

Keywords: subarachnoid hemorrhage seizures prophylaxis levetiracetam
wechat-based intervention for internet addiction

Conditions: Internet Addiction

Summary: the study aims to design an integrated model which combined self-initiated online learning and personalized interactive behavioral support delivered via wechat for university students to reduce internet addiction level.

internet addiction (ia), also described as pathological or problematic internet use, or internet addiction disorders, refers to a pattern of excessive internet use, and it is a new form of behavioral addiction. there are multiple subtypes of ia including excessive online gaming, sexual preoccupations and excessive messages. the excessive use of internet often generates distress or impairments, and evidence showing ia is accompanied by numerous negative impact physically, psychologically and socially such as adhd, interpersonal sensitivity4, depression and anxiety, family discord, social problems. pervious study also suggested ia has a significant correlation with academic performance decrement among students, who were considered as a particular vulnerable population being addicted to internet due to easy access to internet, flexible schedule, positive social atmosphere for computer/smartphone use and lack of parental supervision of internet use. ia is a relatively recent and widespread phenomenon. it was estimated 11% chinese university students were addicted to internet, and an increase in internet use among chinese children and adolescents was observed amid the covid-19 epidemic. ia is believed have some similarities with substance addiction (e.g. smoking, alcohol drinking and drug abuse) as subjects would undergo same symptoms such as depressed, anxious and lonely, affect neurobiology system with common mechanism, and both suffer from substance withdrawal. the interventions for substance addiction have been adopted to treat ia with promising effect including pharmacotherapy, cognitive behavior therapy (cbt), family-based intervention and motivational interviewing, while the treatment for ia has not been standardized yet. in view of the similar characteristics of ia with substance addiction, brief advice and mobile phone-based personalized behavioral support could be feasible to treat ia which has been proven effective in our previous community-based smoking cessation trial, and the covid-19 epidemic increased the acceptance of mhealth interventions. the specific objectives are: 1. . to examine the effectiveness of the integrated model in reducing ia in university students; 2. . to assess the acceptability and feasibility of using the model.

Eligibility criteria:
inclusion criteria: * 1). currently a full-time university student in hk; * 2). aged 18-25 years; * 3). internet addiction test (iat) \> 50; * 4). able to understand and communicate in chinese; * 5). own a smartphone can access internet and proficiency in using wechat; exclusion criteria: * 1) currently participating in other internet addiction controlling projects or services; * 2) experiencing psychiatric/psychological diseases or receiving regular psychotropic medication.

Keywords: internet addiction university students wechat-based
dependence on analgesics in chronic non-cancer pain

Conditions: Pain, Chronic

Summary: the identification of an addiction to opioid analgesics has become strong recommendation for the purpose of improving the clinical management of the patients. however, the success of the patient's clinical management, in terms of analgesia and treatment of drug dependence, rests on the acceptance of this management by the patient himself. the main objective of this study is to evaluate the factors associated to the discrepancy between the assessment of dependence on analgesic drugs by the algologist and the perception that the patient with non-cancer chronic pain has of this dependence.

the long-term use of opioid analgesics for the treatment of chronic non-cancer pain exposes patients to the risk of developing drug dependence on these psychoactive drugs with loss of control of their use. in general medicine as well as in algology consultation, the identification of an addiction to opioid analgesics (and even misuse as a gateway to addiction) have thus become strong recommendations for the purpose of improving the management of the patients. however, the success of the patient's clinical management, in terms of analgesia and treatment of drug dependence, rests on the acceptance of this management by the patient himself. the discrepancy between the assessment of drug dependence on analgesic drugs by the algologist and the perception that the patient has of this dependence will be investigated through a multicentre cross-sectional descriptive survey performed in pain treatment centres in france. in addition to opioid analgesics, other pharmacological classes used for analgesic use will be investigated as they are concerned with the development of drug dependence. this is particularly the case for gabapentins.

Eligibility criteria:
inclusion criteria: * suffering from chronic non-cancer pain, * taking at least one analgesic medication exclusion criteria: * patient minor or major protected by the law (under tutelage), * patient with chronic pain of cancerous origin, * opposition of the patient to be included in the study, * patient not having the overall skills to complete a self-questionnaire: major difficulties in understanding the french language and / or reading / writing difficulties.

Keywords: analgesics
effect of recombinant human brain natriuretic peptide on ventricular remodeling and cardiac function in patients with acute anterior myocardial infraction undergoing percutaneous coronary intervention

Conditions: Ventricular Remodeling; Myocardial Infarction, Anterior Wall

Summary: this study is designed to evaluate the efficacy and safety of recombinant human brain natriuretic peptide (rhbnp) in improving ventricular remodeling and cardiac function after acute anterior myocardial infarction undergoing percutaneous coronary intervention. 100 patients with acute anterior myocardial infarction after primary percutaneous coronary intervention (ppci) are randomly assigned 1:1 to rhbnp group(n=50) and control group(n=50) with follow-up of 24 weeks. both groups are treated with standard therapy of aami, with the rhbnp group intravenous dripping rhbnp after ppci for 3 days and the control group treated with placebo at the same time. the primary endpoint is the change in n terminal pro-b-type natriuretic peptide（nt-probnp ）and cardiac troponin t(ctnt) level.the secondary endpoint is the change in 24-week echocardiographic including left ventricle ejection fraction (lvef) , left ventricular end-diastolic volume index (lvedvi) and left ventricular end-systolic volume index (lvesvi), arrhythmia and cardiovascular events (death, cardiac arrest or cardiopulmonary resuscitation, hospitalization due to heart failure or angina pectoris).


Eligibility criteria:
inclusion criteria: 1. the first acute anterior myocardial infarction ( ami ) within 12 hours ( or more than 12 hours but the ischemic symptoms continue ). 2. age 18-75 years old, gender unlimited 3. patients with acute anterior myocardial infarction undergoing emergency pci within the effective time window 4. successful reflow after interventional therapy ( timi = 3 ). 5. to understand and sign the informed consent. exclusion criteria： 1. patients with a history of coronary artery bypass grafting 2. patients with cardiogenic shock 3. patients with systolic blood pressure ( sbp ) ≤ 90 mmhg after treatment with vasopressors 4. patients with mechanical complications ( ventricular septal perforation, mitral chordae rupture ) 5. patients with suspected aortic dissection 6. patients with severe liver and kidney dysfunction 7. allergic or intolerant to rhbnp. 8. patients with chronic renal insufficiency requiring long-term dialysis 9. patients using diuretics during the screening period 10. pregnant / lactating women 11. heart diseases that are not suitable for vasodilators, such as severe valve stenosis, restrictive cardiomyopathy, restrictive pericarditis, etc

Keywords: myocardial infarction, anterior wall recombinant human brain natriuretic peptide ventricular remodeling percutaneous coronary intervention
open-label, sequential step, safety and efficacy study to determine the optimal single dose of ambisome for patients with vl

Conditions: Visceral Leishmaniasis

Summary: this is a phase ii/iii open, comparative dose trial to find the lowest single dose of ambisome for the treatment of primary, symptomatic visceral leishmaniasis(vl), in hiv negative patients. in this trial, the minimum effective dose will be determined in a sequential step, dose escalation design, which minimises the number of patients exposed to low, potentially inadequate doses and provides contemporaneous comparative data against the manufacturer's recommended dose schedule in this indication.


Eligibility criteria:
inclusion criteria: * male and female adults and children aged 4 years or older with no upper age limit (in accordance with manufacturer's instructions) * acute, symptomatic, vl proven by parasitological examination of splenic aspirate (or bone marrow aspirate) with initial parasite index of at least 2+ * haemoglobin \>4g/dl * fever for more than 2 weeks * living within reachable distance of the trial site to enable attendance for follow-up visits * written informed consent to participate (for children, by parent or guardian) * hiv negative status exclusion criteria: * patients 'in extremis' with signs/symptoms indicative of severe vl * patients who have received any anti-leishmanial treatment within the last 6 months * patients who have received any investigational (unlicensed) drugs during 6 months before recruitment * known underlying chronic disease, such as severe cardiac, pulmonary, renal, or hepatic impairment. * renal function tests (serum creatinine) outside the normal range * liver function tests more than 3 times the normal range at study entry * platelet count less than 40,000/ mm3 * known alcohol abuse * pregnancy or lactation * concomitant acute drug usage for malaria and bacterial infection, pneumonia within last 7 days * known hypersensitivity to ambisome or amphotericin b * any other condition which may invalidate the trial
syndrome patterns for chronic atrophic gastritis malignant transformation

Conditions: TCM Syndrome of Chronic Atrophic Gastritis

Summary: chronic atrophic gastritis (cag) is acknowledged as the precancerous stage of gastric cancer (gc). the present study aims to explore traditional chinese medicine (tcm) syndrome features in different stages of cag malignant transformation respectively. the proposed study is a cross-sectional study based participant survey conducted in 4 hospitals in beijing, china. after obtaining informed consent, a total of 2000 study patients will be recruited on-site in hospitals.

cag is acknowledged as the precancerous stage gc. active treatment of cag is vital in arresting malignant transformation. traditional chinese medicine (tcm) has been widely used in treating cag and preventing gc in china. to date, few study has been conducted to assess the syndrome features of different stages of cag malignant transformation combining tcm indicators. the present study aims to explore tcm syndrome features in different stages of cag malignant transformation. the proposed study is a registry study based participant survey conducted in 4 hospitals in beijing, china. after obtaining informed consent, a total of 2000 eligible study patients will berecruited on-site in hospitals. comparative analysis of prevalence of presenting tcm features is conducted using frequency analysis and chi-squared tests, and expressed with composition ratios. exploratory factor analysis,correspondence analysis, association rule analysis, hierarchical clustering analysis, and complex system entropy clustering analysis will be performed respectively for validating features of syndrome in different stages of cag malignant transformation. previous reports on tcm syndrome features for cag exist, but no studies have been undertaken base on large-sampled study design and detailed analysis in different stages of cag malignant transformation respectively. the outcome of our study has the potential to clerify core tcm pathogenesis of cag, facilitate early intervention, and promote optimization of treatment strategies of cag malignant transformation by tcm.

Eligibility criteria:
inclusion criteria: * (1) 18-75 years of age; (2) meeting diagnostic criteria of cag after upper gastrointestinal endoscopy; (3) willing to cooperate with data, tissue sample, and blood sample collection during recruitment; (4) willing to respond truthfully and timely to researcher queries after recruitment, able to cooperate with data, tissue sample and blood sample collection during follow-ups; (5) willing to sign informed consent. exclusion criteria: * (1) meeting past history of previous stomach surgery; (2) unable to participate in data, tissue sample or blood sample collection for any reason.

Keywords: chronic atrophic gastritis malignant transformation syndrome traditional chinese medicine cross-sectional study