Kornimate/medical-research-clean huggingface dataset:
normal values in ano-rectal 3d high resolution manometry

Conditions: Anorectal Disorder; Fecal Incontinence; Constipation

Summary: ano-rectal manometry is indicative in patients with either fecal incontinence or constipation. recently anorectal 3d- high resolution manometry has been developed. pressure variations are measured circumferentially along the anal canal. it may allow a better understanding of anorectal disorders by displaying anal pressure asymmetry and it could be useful to assess the functional anatomy of the pelvic floor better than conventional manometry.


Eligibility criteria:
arm 1: 50 healthy volunteers inclusions will be stratified on gender (10 males, 40 females), age (15 subjects under 40 years; 20 subjects between 40 and 60 years; and 15 subjects \>60 years) and parous (10 nullipara and 30 parous women). inclusion criteria: subject older than 18 years absence of anorectal symptoms (no constipation, no fecal incontinence) absence of pelvic floor disorders vaizey score = 0 kess score \< 9 subject with health insurance written informed consent non inclusion criteria: patient younger than 18 years pregnancy incapability to give consent no written informed consent participation to another study at the same time previous ano-rectal surgery pelvic radiotherapy neurological disorder diabetes mellitus arm 2: 50 patients with fecal incontinence inclusion criteria: subject older than 18 years patient referred for anorectal manometry and/or ultrasound examination fecal incontinence as main complain vaizey score \> 6 kess score \< 9 subject with health insurance written informed consent non inclusion criteria: patient younger than 18 years pregnancy incapability to give consent no written informed consent participation to another study at the same time rectal tumor rectal stenosis ileo-anal or ileo-rectal anastomosis anal fissure anal fistula arm 3: 50 patients with constipation inclusion criteria: subject older than 18 years patient referred for anorectal manometry and/or ultrasound examination constipation as main complain feeling of incomplete evacuation and/or manual disimpaction defined as needing to press in or around the anus to aid defecation vaizey score \< 6 kess score \< 9 subject with health insurance written informed consent non inclusion criteria: patient younger than 18 years pregnancy incapability to give consent no written informed consent participation to another study at the same time rectal tumor rectal stenosis ileo-anal or ileo-rectal anastomosis anal fissure anal fistula

Keywords: primary esophageal achalasia endoscopic myotomy high resolution manometry
safety and efficacy study of guaifenesin and pseudoephedrine for symptomatic therapy to treat acute rti

Conditions: Acute Upper Respiratory Track Infection

Summary: the purpose of this study is to determine if treatment with mucinex d lowers the use of antibiotics in the treatment of upper respiratory infection when compared to placebo


Eligibility criteria:
inclusion criteria: * patients aged 18 to 75 yrs of age presenting at a clinical site with symptoms diagnostic for an acute upper respiratory tract infection within the last 5 days exclusion criteria: * patients who had chronic, recurring respiratory signs and symptoms due to conditions such as chronic allergic rhinitis, chronic sinusitis or chronic bronchitis which in the investigator's opinion, confounded interpretation of symptom ratings for the acute upper respiratory infection. also excluded were patients with a fever greater than 101 degrees f.

Keywords: acute upper respiratory track infection who seek treatment
safety and biomarker study of epi-589 in participants with amyotrophic lateral sclerosis (als)

Conditions: Amyotrophic Lateral Sclerosis

Summary: this is an open label study with 30-day run in phase to establish baseline parameters, 90-day treatment phase, and a 90-day withdrawal phase to determine long-term effects, duration of treatment response, and potential effects of epi-589 therapy on known trajectory.


Eligibility criteria:
inclusion criteria: * diagnosis of possible, probable, laboratory supported probable, or definite als by e1 escorial criteria * forced vital capacity (fvc) ≥ 70% of predicted * weakness onset within 3 years * agreement to use contraception if within reproductive years * willingness and ability to comply with study procedures * stable regimen of dietary supplements and /or riluzole for at least 30 days prior to enrollment * abstention from use of other investigative or non-approved drugs * participants must be able to swallow 0.375 \* 0.700 inch tablets exclusion criteria: * allergy to epi-589 * use of ventilation * participation in other intervention studies * diagnosis of any other neurologic disease * malignancy within the past 2 years * history of stroke * history of brain surgery * hepatic insufficiency with liver function tests (lfts) greater than 3 times upper limit of normal (uln) * renal insufficiency requiring dialysis * end stage cardiac failure * participation in a trial of a device, drug, or other therapy for als within 3 months of screening or during the trial
prevalence, types and risk factors of urinary incontinence among women in baghdad, iraq.

Conditions: Urinary Incontinence; Urge Incontinence; Stress Incontinence

Summary: the goal of this observational study is to observe and describe the prevalence, types, and risk factors of urinary incontinence (ui) in adult women attending primary healthcare centers in baghdad, iraq. the main questions it aims to answer are: * what is the prevalence of incontinence among the targeted group? * what are the types of incontinence and what is the frequency of each type among the targeted group? * what is the effect of several risk factors on the occurrence and severity of urinary incontinence (including age, job, sexual activity, chronic constipation, chronic cough, parity, largest birth weight, and body mass index)? participants will be asked to fill out a questionnaire consisting of the arabic international consultation on incontinence questionnaire-urinary incontinence short form (arabic iciq-ui sf) in addition to questions about the aforementioned risk factors.


Eligibility criteria:
inclusion criteria: * women * attending the primary healthcare centers in baghdad, iraq * older than 18 years exclusion criteria: * patients who refuse to participate in the study.

Keywords: urinary incontinence urge incontinence stress incontinence mixed incontinence
role of ultrasound guided transversus abdominis plane block in pain control after hepatectomy

Conditions: Analgesia

Summary: inadequately managed acute pain following abdominal surgery originates from somatic pain signals in the abdominal wall and is linked to various unfavorable postoperative outcomes. these consequences encompass patient distress, respiratory complications, delirium, myocardial ischemia, extended hospital stays, an elevated risk of chronic pain, heightened analgesic consumption, delayed bowel function, and an increased need for rescue analgesics. this study aims to assess the postoperative analgesic efficacy of ultrasound-guided transversus abdominis plane (tap) block using oblique subcostal and posterior approaches in hepatectomy.

pain control is vital to achieve enhanced recovery after abdominal surgeries . tap block had been demonstrated to improve pain related outcomes after abdominal surgeries. postoperative pain management for patients undergoing hepatic resection is a challenge due to the risk of perioperative liver dysfunction.tap block is a promising regional analgesic technique. this study aimed to evaluate the effect of us-guided subcostal approach versus combination of both subcostal and posterior approaches of tap block the patients will be randomly divided into two groups : group a will recieve oblique subcostal tap block and group b will recieve both subcostal and posterior tap block .

Eligibility criteria:
inclusion criteria: * asa i and ii patients. aged 18 to 50 years. 70 to 80 kg. exclusion criteria: * patients under 18 years of age. * history of allergic reactions to study drugs. * opioid or analgesic abuse, and chronic treatment with opioids, or non-steroidal anti-inflammatory drugs. * history of bleeding tendency or coagulopathy .
ciprofloxacin versus levofloxacin in stem cell transplant

Conditions: Prophylaxis; Stem Cell Transplant Complications

Summary: ciprofloxacin and levofloxacin are both in guidelines to use for prophylaxis in autologous and allogeneic stem cell transplant.ciprofloxacin was recently replaced by levofloxacin as the preferred agent in some transplant centers. in some small retrospective studies ciprofloxacin prophylaxis was associated with a higher rate of breakthrough gram positive bloodstream infections. however, the optimum oral agent for antibacterial prophylaxis in transplant recipients remains uncertain.


Eligibility criteria:
inclusion criteria: * patients 18-75 years of age with a diagnosis of a hematological malignancy. meet the stem cell transplant program criteria to undergo autologous or allogeneic hematopoietic stem cell transplantation. exclusion criteria: * prolonged qt * allergies to ciprofloxacin or levofloxacin
relationship of cervical region tension with vagal function

Conditions: Gastrointestinal Diseases; Autonomic Nervous System Disease

Summary: the increase in the tension of the soft tissues around a nerve restricts the movement, affects the function of the nerve, and makes the nerve vulnerable to entrapment. even a mild nerve compression can cause entrapment and lead to neuroinflammation. it is known that inflammatory mediators amplify axonal sensitivity. although the spontaneous discharge potential of visceral afferents is quite low under normal conditions, neuroinflammation increases the excitability of these fibers. with this mechanism, hyperalgesia may develop in sensory fibers in neuroinflammation. this may cause pathologies in the organs innervated by the relevant nerve. the fascia and muscles of the cervical region surround the vagus nerve. there are two main fascial compartments in the cervical region. the scm and trapezius muscle fascias join to the most superficial fascia of the deep cervical fascia and they together form these compartments. these fasciae superiorly attach to the cranium and inferiorly to the pectoral region. the vagus nerve emerges from the jugular foramen together with the 9th and 11th cranial nerves. it then continues through the carotid sheath in the cervical region. the carotid sheath is in contact with the scm muscle. for this reason, it can be thought that scm muscle tension or thickness may affect the carotid sheath and thus the function of the vagus nerve passing through it. in summary, deterioration in vagus nerve activity plays a role in pathologies of the organs innervated by the vagus. although the relationship between vagal dysfunction and gastrointestinal system symptoms is clear, the mechanisms affecting vagus nerve function have not yet been clarified. it has been reported in the literature that some maneuvers from the cervical region are also effective on the vagus nerve. also, according to investigators' clinical experience, gastrointestinal symptoms are frequently observed in patients with increased cervical soft tissue tension. however, there are not enough studies investigating whether the cervical region soft tissue tension can affect the gastrointestinal system via the vagus nerve. therefore, this study was planned to examine the relationship of cervical soft tissue tension with vagus nerve function and gastrointestinal symptoms in asymptomatic individuals and individuals with neck pain.


Eligibility criteria:
inclusion criteria: * being 18-50 of age, * having less than 30 body mass index, * being a volunteer exclusion criteria: * having any type of malign disease, * being diagnosed with a systemic disease (cardiologic, gastrointestinal, rheumatological, neurological, etc.), * having any type of surgery within the last 6 months, * being diagnosed with whiplash syndrome * having an unhealed fracture * pregnancy * using prescribed medicine for the gastrointestinal system

Keywords: vagus nerve muscle tonus autonomic nervous system diseases pain threshold
lymphocytic herpesviruses and cerebrospinal fluid polymerase chain reaction (pcr)

Conditions: Central Nervous System Infection

Summary: enterovirus and herpes simplex viruses 1 and 2 are the main causative agents of central nervous system infections. instead, the role of lymphocytic herpesviruses in the etiology of central nervous system (cns) infections is not clear, even if there is the positive cerebrospinal fluid (csf) polymerase chain reaction (pcr)-result for the virus. the aim of this study is to evaluate the presence of dna from lymphocytic herpesviruses in the csf obtained from the immunocompetent patients with csf pleocytosis and from the patients with normal csf leukocyte count.


Eligibility criteria:
inclusion criteria: * immunocompetent patients with clinical symptoms and signs of central nervous system infections and csf pleocytosis (pleocytosis group) * immunocompetent patients without suspicion of cns infection and no csf pleocytosis (non-pleocytosis group) exclusion criteria: * suspicion of cns-infection, eg. encephalitis, but no csf leukocytosis (pleocytosis group) * patients without symptoms of cns infection, but who has csf pleocytosis of unknown origin (non-pleocytosis group)

Keywords: csf pcr lymphocytic herpesvirus cns
comparison of exenatide and metformin monotherapy in overweight/obese patients with newly diagnosed type 2 diabetes

Conditions: Type2 Diabetes

Summary: the present study assessed the therapeutic effect of exenatide and metformin as the initial therapy in overweight/obese patients with newly diagnosed type 2 diabetes (t2d).

the present study was a prospective, nonrandomized, interventional study.the drug-naïve, overweight or obese patients with newly diagnosed t2d were consecutively enrolled. the inclusion criteria: 1) age 20 - \<65 years, 2) body mass index (bmi) ≥ 24 kg/m2 \[7\], and 3) hba1c ≥ 7% (53mmol/mol). an oral glucose tolerance test was performed during the screenings. all of the patients have no diabetes antibodies and were diagnosed with t2d within the previous 3 months, according to the ada diagnostic criteria. none of the patients had administered anti-diabetic drugs or diet therapy before participation. neither of the patients presented any history of pancreatitis, coronary artery disease, liver function impairment, renal function impairment, intestinal surgery, chronic hypoxic diseases (emphysema and cor pulmonale), infectious disease, hematological disease, systemic inflammatory disease, or cancer. patients who were pregnant, possibly pregnant, or ingesting agents known to influence glucose or lipid metabolism were also excluded.

Eligibility criteria:
inclusion criteria: * age 20 - \<65 years, * body mass index (bmi) ≥ 24 kg/m2, * hba1c ≥ 7% (53mmol/mol). * diabetes antibodies (-) * diagnosed with t2d within the previous 3 months exclusion criteria: * anti-diabetic drugs or diet therapy before participation * pancreatitis * coronary artery disease * liver function impairment * renal function impairment * intestinal surgery * chronic hypoxic diseases (emphysema and cor pulmonale) * infectious disease * hematological disease * systemic inflammatory disease * cancer * pregnant, possibly pregnant * ingesting agents known to influence glucose or lipid metabolism
low-frequency transcranial magnetic stimulation to enhance motor recovery in the subacute phase after stroke

Conditions: Stroke

Summary: low-frequency repetitive transcranial magnetic stimulation (rtms) of the unaffected hemisphere (uh) transiently improves motor function in patients in the chronic phase after stroke. the goal of this study is to investigate effects on motor recovery of low-frequency rtms of the uh, administered in the subacute phase after stroke.

stroke is a major cause of disability and worldwide. hand motor impairment is frequent after stroke. even mild impairments of the upper limb negatively impact disability and quality of life in these patients significantly contributes to disability. therapeutic alternatives for hand motor rehabilitation are deeply needed. repetitive transcranial magnetic stimulation (rtms) has emerged as a potential tool to improve hand motor performance after stroke. while high-frequency rtms (hf-rtms) often increases motor cortical excitability, lf-rtms often has the opposite effect. up-regulation of excitability in the affected hemisphere by hf-rtms or down-regulation of the uh by lf-rtms can restore the balance in inter-hemispheric inhibition and hence, facilitate movement of the paretic hand both strategies, as well as the combination of both, have yielded encouraging results when applied in proof-of-principle, single-session studies to patients with mild hand motor impairment in the subacute and chronic stages after stroke. however, few rtms studies included patients less than six months after stroke, and effects of lf-rtms of the unaffected hemisphere in patients with severe motor impairment in the subacute phase have not been yet reported. the investigators opted for a novel approach to enhance hand motor recovery, by examining feasibility, safety and preliminary efficacy of either active or sham lf-rtms of the uh or sham rtms as add-on therapies to outpatient customary rehabilitation, to patients with mild to severe hand paresis, within 5-45 days after unilateral ischemic stroke. the investigators hypothesize that, at this stage, lf-rtms will be feasible even in patients with severe motor deficits, will have minimal adverse events and will enhance effects of customary rehabilitation on hand motor performance.

Eligibility criteria:
inclusion criteria: * first-ever ischemic stroke in the internal carotid artery territory confirmed by ct or mri, 5-45 days before, leading to contralateral hand weakness * age, 18-80 years exclusion criteria: * cardiac pacemaker * pregnancy * implantable medication pump * intracranial hypertension * history of seizures * metal in the head * decompressive surgery * other neurological diseases * shoulder pain * joint deformity in the paretic upper limb * severe chronic disease such as end-stage cancer or end-stage renal failure * inability to provide informed consent due to severe language or cognitive impairment
body composition, dietary behaviors, energy expenditure and physical activity among moroccan schoolchildren and adolescents

Conditions: Body Composition; Physical Activity

Summary: considering the increasing public health concern the obesity in morocco, the aim of the present study was to use isotope techniques to assess body fat, total energy expenditure and physical activity to inform design and improve interventions for the prevention and control of obesity and related health risks such as diabetes and elevated blood pressure among children and adolescents. specific objectives of the trial: 1. determine the extent of obesity and physical activity levels in children and adolescents to design effective interventions in the school setting. 2.propose alternative field based techniques for assessing body composition and physical activity that could be used in largescale situation assessments and in assessing interventions to address obesity and risk related health care. \* for body composition: bmi z-score, waist circumference, waist measurement at height. \* for physical activity: questionnaire, accelerometers 3. to identify factors contributing to the development of obesity and related health risks in schoolchildren and adolescents. 4. collaborate with stakeholders (government, schools and / or colleges, communities and development partners) in designing interventions to address obesity and health risks. 5. to recommend to stakeholders the most effective interventions in schools to prevent and combat obesity and health risks in children and adolescents.


Eligibility criteria:
inclusion criteria: * apparently healthy * aged between 8 to 14 years old exclusion criteria: * hypo or hypervolemic conditions including diet * diuretics and oedema * private schools * rural area

Keywords: obesity body composition energy expenditure sedentarity dietary behaviors
validation study of a digital measuring device for central hand representation in children with a neonatal brachial plexus palsy

Conditions: Neonatal Brachial Plexus Palsy

Summary: hand function is one of the most complex and sophisticated sensorimotor skills, controlled by the interplay of precise motor efferent and multisensory afferent stimuli. a coherent central representation of the hand is essential for performing hand movements in a changing environment. however, the hand representation in the brain consists of many modalities (visual, proprioceptive, anthropometric,...). the division between explicit (conscious) and implicit (unconscious) representation of the hand is accepted by a large group of researchers. the explicit representation of the hand is based partly on visual afferents, the implicit on all other afferent inputs. impaired hand function in everyday use after injury may be due to aberrant hand representation. previous research showed that children with neonatal brachial plexus injury have impaired implicit hand representation with respect to hand size. despite the good reproducibility of test results reported in the literature, the measurement method is very cumbersome. in the current technological revolution, digitalisation of the device is the ideal solution to make the measurement method clinically applicable in daily practice. therefore, a new prototype digital device has been developed to automate the measurement method. this prototype works on the same principle and has the same dimensions as previous studies. it includes digital storage and processing of the measurement results. this study investigates the reproducibility (inter- and intra-observer) of the digital prototype. the study will recruit children aged between 8 and 18 years with a neonatal brachial plexus injury. doctors treating this patient group will explain the study during consultations and provide a flyer. participation in the study means that the patient will be invited to the uz ghent paediatric rehabilitation centre, where two different doctors will independently perform the measurement. specifically, they will be asked to place their hand on a mat and the fingertips, knuckles and wrist will be marked on the device. a wooden board is then placed over the hand so that the hand is no longer visible. the subject is then asked to indicate the fingertips, knuckles and wrist in random order, again recorded on the device. the test takes 5 to a maximum of 10 minutes (depending on cooperation). this measurement is repeated a 6 times on each hand. based on these measurements, the device calculates the average of each participant's perceived hand width and finger length. these values are compared with the actual hand width and finger length. this allows us to calculate a percentage of overestimation. studies using such data have already been published. the aim of this study is to measure the reproducibility (inter- and intraobserver) of the digitised version.


Eligibility criteria:
inclusion criteria: * presence of a neonatal brachial plexus palsy exclusion criteria: * presence of any other important locomotor, neurological or psychiatric disorder