Kornimate/medical-research-clean huggingface dataset:
perineural versus systemic dexamethasone to prolong regional anesthesia in front foot surgery

Conditions: Pain Management After Surgery

Summary: both perineural and systemic dexamethasone administration allows an increase in analgesic duration of regional anesthesia. there is a lack of data to determine wich route allows a longer analgesic effect. this study aims to determine wether perineural dexamethasone allows a longer analgesic duration than systemic route in combination with regional anesthesia (ropivacaine 0.375%) for front foot surgery.

this is a prospective, randomized, double-blind controlled trial. all patients undergoing front foot surgery with metacarpal osteotomy will be screened for inclusion in the protocol. all patients without exclusion criteria will be included in the study. all patients will receive 30cc mixure of ropivacaine 0,375% in perineural injection and surgery will be performed under regional anesthesia only. if needed, a sedation with midazolam (1mg) will be performed. the patients will be randomized over 2 groups: * "perineural group": * 1cc (4mg) of dexamethasone will be administrated in perineural injection * 2.5cc of isotonic saline solution will be administrated in systemic injection * "systemic group": * 1cc of isotonic saline will be administrated in perineural injection * 2.5cc (10mg) of dexamethasone will be administrated in systemic injection for both groups perineural injection will be performed at the ankle and the following nerves will be targeted: the tibial nerve, saphenous nerve, the deep fibular nerve, the superficial fibular nerve and the sural nerve. post-operative analgesia will be reached with paracetamol (1gr each 6 hours) and ketoprofen (100mg each 12 hours). after surgery, patients will be asked to write down the time to the first opioids request during the first 48 hours, maximal pain during the first 48h using a visual analog scale, occurrence of nausea or vomiting, overall satisfaction regarding pain relief management and any significant side effects during the first 7 days. the primary objective of the study is to determine if perineural dexamethasone is associated with a longer analgesic duration than systemic route in combination with regional anesthesia (ropivacaine 0.375%) for front foot surgery. the primary end-point will be time to the first opioids request during the first 48 hours.

Eligibility criteria:
inclusion criteria: * front foot surgery with metacarpal osteotomy under regional anesthesia * \>18 years old * consent to participate in the study exclusion criteria: * refusal to participate * pregnancy * feeding * pre existing neuropathy * ropivacaine allergy * paracetamol allergy * liver failure * cardiac failure * ketoprofen allergy * gastric ulcer within the previous year * tramadol allergy * history of epilepsy

Keywords: dexamethasone regional anesthesia front foot surgery metacarpal osteotomy
effect of pre-warming of local anesthesia in reducing pain perception during injection in children

Conditions: Local Anesthesia; Dental Anesthesia

Summary: the aim of the current study was to evaluate the pain perception upon injection of pre-warmed dental anesthetic solution (at 370c and 400c) versus that at room temperature (average 23 degrees) during maxillary infiltration and mandibular inferior alveolar nerve block techniques in children


Eligibility criteria:
inclusion criteria: * healthy patients with asa 1 or 2 classification. * patients with frankl behavior classification 3-4. * patients having at least one carious primary molar that requires dental treatment under the effect of local anesthesia. * parents' willingness to participate through informed written consent. exclusion criteria: * patients with previous negative dental experience. * patients complaining of cellulitis or infection spreading in the fascial spaces. * patients who have received analgesics within the previous 12 hours before receiving the required dental treatment. * patients with any intellectual impairment. * patients with a history of allergy from any of the components of the dental anesthetic carpule.
educational intervention for asthmatic and allergic patients

Conditions: Asthma; Allergy

Summary: despite its importance, there are few studies that implement the use of new technologies in the approach to patients with asthma and allergy. therefore, the objective of this study is to evaluate the effectiveness of a telematic educational intervention in patients with allergies and / or asthma


Eligibility criteria:
inclusion criteria: * asthmatic and allergic patients exclusion criteria: * cognitive impairment. * diagnose of autism spectrum disorder or severe intellectual disability * physical or functional impairment that limits the performance of evaluation
the cardiovascular effects of ginger (zingiber officinale) in patients with type ii diabetes mellitus

Conditions: Cardiovascular Benefits of Zingiber Officinale Roscoe in Patients With Type 2 Diabetes Mellitus Before and After 6 Weeks of add-on Therapy

Summary: the aim of the study was the evaluation of cardiovascular benefits of zingiber officinale roscoe in patients with type 2 diabetes mellitus before and after 6 weeks of add-on therapy.

the investigators performed a non-randomized single-arm clinical trial with a before and after design, carried out from december 2016 and may 2017. intervention consisted of the administration of powdered ginger extracts in the form of capsules at a dose of 2g/day, for a period of 6 weeks. before and after intervention, the following were done by the participants: bioelectrical impedance analysis (bia), blood pressure measurements, fasting blood sugar, hba1c, lipid profiles, liver function tests, kidney function tests and full blood counts. these were followed by morphological workup including electrocardiograms (ecgs), transthoracic heart ultrasounds and ambulatory blood pressure measurements (abpm), also done before and after intervention. clinical evaluation with fasting blood sugar control and blood pressure controls were done at day 21 for safety purposes.

Eligibility criteria:
inclusion criteria: * known t2dm patients aged above 21years * no change in anti-diabetic medication during the last three months. * hba1c between 42 to 64mmol/mol (6-8%). exclusion criteria: * patient already on ginger supplementation or other herbal medication * drugs that could interact with ginger or whose effects may be amplified such as nsaids, corticosteroids and anticoagulants like heparin or warfarin, as far back as 1 month before study. * cardiac, renal disease and liver pathologies * heartburn or peptic ulcer disease * sensitivity, intolerance or allergy to ginger * discontinued intervention * withdrawal of consent

Keywords: diabetes mellitus diastolic function blood pressure zingiber officinale
age, traumatic brain injury and injury severity as independent risk factors for in-hospital mortality in polytrauma patients.

Conditions: Polytrauma; Traumatic Brain Injury

Summary: in this study patients who were admitted to our hospital with critical injuries were enrolled retrospectively from january 2012 to december 2015. patients with an iss\>16 points, an ais \>3 in one body region and at least 2 different body regions affected were included. possible prognostic factors were evaluated.


Eligibility criteria:
inclusion criteria: * iss \>16 points * ais \>3 in one body region * at least 2 body regions affected exclusion criteria: * patients younger than 18 years of age * isolated traumatic brain injury * minor injuries (ais \<3 or iss \<16 points)

Keywords: prognostic factors new berlin definition polytrauma
genetic variants in linear localized scleroderma

Conditions: Morphea

Summary: the purpose of this study is to investigate the genetic architecture of linear localized scleroderma (lls) (linear morphea) by whole exome sequencing.

at present the etiology of lls is unknown, but a genetic background is suspected. although lls clearly classifies as a mosaic disorder, its genetics and protein machinery remain to be understood. we are going to use a tailored approach to identify the genetic factors of lls. in the first phase of the study we will investigate the genetic architecture in lls. wes will analyze whole protein coding dna in skin samples of 50 consenting lls patient. the aim is to identify the key genes associated with lls. in the second phase of the study subsequent functional experiments will be performed. based on the identified candidate genes, knockdown and overexpression models will be created with relevant cell lines (fibroblasts) to identify the biological consequences and confirm the functional relevance of the identified genetic mutations in lls. further the protein network active in lls will be investigated (proteomic analysis). the described basic genetic studies combined with functional experiments will lay the groundwork for treatment trials to provide possibly novel treatment options.

Eligibility criteria:
inclusion criteria: * male or female subjects ≥ 5 years of age with well phenotyped lls * affecting their head and / or face "termed " en coup de sabre " type lls or hemiatrophia faciei or parry-romberg syndrome, with or without therapy * affecting any site of the body except the head or face, with or without therapy exclusion criteria: * patients with signs of systemic scleroderma * patients with localized scleroderma (morphea) other than the linear type ("plaque-type", "morphea profunda", "generalized morphea") patients with diagnosed gadolinium induced scleroderma patients with post-irradiation scleroderma patients with missing consent
defining the intestinal microbiota in premature neonates

Conditions: Premature Intestinal Microbiota; Necrotizing Enterocolitis; Late Onset Bloodstream Infection

Summary: the investigators will collect daily faecal samples from premature (\<32 weeks) infants in the intensive care unit from the day of birth until they are discharged. by using newly developed molecular detection techniques the investigators aim to define more precisely than has ever previously been attempted, all the species of bacteria present in the faeces. this will enable comparison of the pre-morbid and post-morbid intestinal microbiota (all the bacteria in the gut) in premature neonates.

highly premature infants are susceptible to serious infections such as necrotizing enterocolitis (nec) and late-onset blood stream infections (bsis). nec is a poorly understood, potentially life-threatening bowel disorder. it is thought that bacteria proliferating abnormally in the bowel may play an important part in its cause, but no single pathogen has yet been identified. bsis are commonly caused by gut bacteria. as the highly premature gut is fragile and has increased permeability, poor motility and decreased immune defences, localised inflammation caused by abnormal bacterial growth may allow 'bystander' microbes to translocate through the gut into the blood stream leading to systemic infection. in a small proportion of infants who develop nec, surgery will be required as part of treatment of the condition. in these infants the investigators will seek consent to collect a small part of the diseased bowel which has been removed. similar analysis will be performed on these samples. the analysis of the tissue samples will give us an indication of how well the faeces act as a proxy for the intestinal microbiota. in this ecological study of the evolution of the intestinal microbiota in preterm infants, by comparing samples from babies who develop nec or late-onset bsi with those of well babies the investigators will be able to look for differences characteristic of the conditions. this information will help aid design of prevention or treatment strategies.

Eligibility criteria:
inclusion criteria: * all premature babies born at less than 32 completed weeks gestation who are admitted to an imperial college nhs healthcare trust neonatal intensive care unit (st. mary's hospital or queen charlotte's \& chelsea hospital), and whose parents/guardians have given their consent will be eligible to enter the study. exclusion criteria: * all babies born at more than 32 completed weeks gestation will be excluded from the study.

Keywords: premature intestinal microbiota necrotizing enterocolitis
a prospective study to evaluate mri guided biopsy compared with transrectal ultrasound guided biopsy of the prostate in men with increased psa values

Conditions: Prostate Cancer

Summary: the purpose of this study is to determine whether mri guided prostate biopsy achieves higher prostate cancer detection rates compared with transrectal ultrasound guided prostate biopsy in patients with increased psa values \> 4.0 ng/ml.


Eligibility criteria:
inclusion criteria: * psa \> 4.0 ng/ml * written informed consent * age \>18 exclusion criteria: * patients with prostate cancer * patients with prior prostate biopsy * patients with contraindications against mri or biopsy

Keywords: prostate biopsy mri guided biopsy trus guided biopsy
renal impairment study

Conditions: Clinical Trial, Phase I

Summary: the study will investigate the pharmacokinetics of bay1142524 in subjects with mild to severe renal impairment compared to age; weight, and gender-matched healthy subjects.


Eligibility criteria:
inclusion criteria: * body mass index (bmi): 18 to 34 kg/m² (both inclusive) * men or confirmed postmenopausal women (by medical report verification and defined as exhibiting natural amenorrhea for at least 12 months before screening or as exhibiting natural amenorrhea for at least 6 months before screening with documented serum follicle-stimulating hormone levels \>40 miu/ml, provided that no prior hormonal treatment has taken place) or women without childbearing potential based on surgical treatment at least 6 weeks before screening such as bilateral tubal ligation, bilateral oophorectomy or hysterectomy (documented by medical report verification). * subjects with renal impairment: egfr \<90 ml/min/1.73 m\*2 determined from serum creatinine 2 -10 days prior to dosing. stable renal disease, i.e. a serum creatinine value determined at least 3 months before the pre-study visit (e.g. during routine diagnostics) should not vary by more than 20% from the serum creatinine value determined at the pre-study visit - healthy subjects egfr ≥90 ml/min/1.73 m\*2 determined from serum creatinine 2 -10 days prior to dosing. needs to be within the required age and body weight range of group 1 (which should not vary by more than+- 10 years and +-10 kg to groups 2-4). exclusion criteria: * clinically relevant findings(e.g. blood pressure, electrocardiogram, ecg; physical examination,laboratory examination) * relevant impairment in liver function. * pre-existing diseases (including impairment of liver function) for which it can be assumed that the absorption, distribution, metabolism, elimination and effects of the study drugs will not be normal. * any organ transplant \< 1 year before participation in this study. * subject under dialysis or planned to start dialysis during participation in the study. * failure of any other major organ system other than the kidney.
prolonged manual ventilation simulation

Conditions: Manual Ventilation

Summary: a pilot study on simulated lung scenarios using the standard manual resuscitator bag, flow limiting resuscitator bag, and an fda approved flow rate limiting device paired with a standard manual resuscitator.


Eligibility criteria:
inclusion criteria: * 18 years old or older * have a current basic life support (bls) certification * be available for the entire 10 hours to complete the protocol exclusion criteria: * any training in medical school or respiratory therapy school * not being available for the full 10 hours to complete the protocol

Keywords: prolonged manual ventilation simulation bvm sotair bls certification tidal volume peak inspiratory pressure
application of painting analysis and psychotherapy in children with bone tumors

Conditions: Bone Tumors

Summary: in the population suffering from cancer, children and teenagers are in the majority. for children with rapid development of body and mind, with the change of cognitive ability, they will feel anxiety and fear about the expected potential negative events. painting art therapy is a kind of non-verbal psychological therapy through the interaction between the painter, the painting work and the therapist, with the painting creation activity as the intermediary. the purpose is to develop symbolic language, touch the inner subconscious, and integrate into the personality, so as to produce cognitive and behavioral changes. painting therapy and psychological analysis can improve the treatment compliance of children bone tumor patients, make psychological nursing and health education of patients more targeted, and promote the cooperation between medical care and patients.

in the population suffering from cancer, children and teenagers are in the majority. for children with rapid development of body and mind, with the change of cognitive ability, they will feel anxiety and fear about the expected potential negative events. painting art therapy is a kind of non-verbal psychological therapy through the interaction between the painter, the painting work and the therapist, with the painting creation activity as the intermediary. the purpose is to develop symbolic language, touch the inner subconscious, and integrate into the personality, so as to produce cognitive and behavioral changes. painting therapy and psychological analysis can improve the treatment compliance of children bone tumor patients, make psychological nursing and health education of patients more targeted, and promote the cooperation between medical care and patients. forty pediatric bone tumor patients meeting the requirements were selected from the bone and soft tissue ward of our hospital. twenty subjects were randomly divided into experimental group and control group. the experimental group underwent psychological evaluation, drawing analysis and psychotherapy intervention before and after chemotherapy and surgery, while the control group only underwent psychological evaluation without drawing analysis and psychotherapy intervention. this experiment was designed to evaluate the change of psychological state of children after intervention. to verify whether the intervention has improved the psychological and cognitive aspects of the children.

Eligibility criteria:
inclusion criteria: 1. ages 7-16 2. no gender limitation 3. pathologically confirmed patients with osteosarcoma and ewing's sarcoma 4. have painting ability exclusion criteria: 1. those who do not cooperate 2. family members or patients reject this treatment technique 3. the patient has severe intellectual disability; 4. the patient's condition is in critical stage or bone marrow suppression stage or complicated with serious complications.
cognitive function after stem cell transplantation

Conditions: Fatigue; Cognitive Impairment; Stem Cell Transplantation

Summary: the trial will evaluate the effects of an exercise program on the physical and cognitive performance of patients with hematological neoplastic diseases after high dose chemotherapy with stem cell support.

patients (n = 60) will be randomized to an exercise or a control group. the randomization will be stratified for allogeneic or autologous blood stem cell transplantation. patients in the exercise group will carry out an endurance training consisting of walking on a treadmill at a speed corresponding to 80% of the maximum heart rate. the exercise program will be carried out 3 times weekly for 8 weeks. patients in the control group will receive counseling about exercise and behavioural techniques to reduce fatigue, but they will not participate at a structured exercise program. physical performance (vo2max), cognitive function, mood and quality of life will be evaluated at recruitment and after 8 weeks.

Eligibility criteria:
inclusion criteria: * age 18 - 70 * hematological neoplastic disease * treatment with high-dose chemotherapy with peripheral blood stem cell transplantation in the previous 3 years * karnofsky-index \> 80% * ability to understand german exclusion criteria: * cardiorespiratory, metabolic, inflammatory or osteoarticular diseases which can be aggravated by exercise * psychosis * organic brain damage * dementia * pbsct in the previous 6 weeks * pathological stress test at admission

Keywords: fatigue cancer cognitive impairment exercise sport peripheral blood stem cell transplantation high-dose chemotherapy
study investigating oct, multifocal erg, and microperimetry in monthly versus prn ranibizumab in neovascular age-related macular degeneration

Conditions: Neovascular Age Related Macular Degeneration

Summary: visual outcomes using monthly ranibizumab therapy are well established in clinical trials, but the best way to assess when and how to treat patients with prn therapy has not been proven. information is lacking on multi-focal erg and microperimetry outcomes with ranibizumab therapy. additionally, va and oct outcomes don't always correlate and other assessments such as the multi-focal erg and microperimetry may be useful as early predictors of when patients should be retreated. this study will assess 2 groups (monthly and prn therapy) and assess high resolution oct, microperimetry, and multi-focal erg outcomes. for the prn group retreatment will be based on oct criteria. we will investigate if microperimetry or multifocal erg would have been an early predictor of fluid recurrence.


Eligibility criteria:
inclusion criteria: * ability to provide written informed consent and comply with study assessments for the full duration of the study. * age greater or equal to 50 years old. * patients with active neovascular amd exclusion criteria: * pregnancy (positive pregnancy test) or lactation. * premenopausal women not using adequate contraception. the following are considered effective means of contraception: surgical sterilization or use of oral contraceptives, barrier contraception with either a condom or diaphragm in conjunction with spermicidal gel, an iud, or contraceptive hormone implant or patch. * any other condition that the investigator believes would pose a significant hazard to the subject if the investigational therapy were initiated * participation in another simultaneous medical investigation or trial * concurrent eye disease in the study eye that could compromise visual acuity (e.g., diabetic retinopathy, advanced glaucoma) * previous pdt therapy * previous intravitreal steroid therapy within last 3 months * previous anti-vegf therapy in the past month

Keywords: armd amd exudative amd