Kornimate/medical-research-clean huggingface dataset:
radiomics model based on dce-mri and ultrasound images for breast lesion classification

Conditions: Breast Diseases

Summary: to develop and compare multi-modality radiomics models based on dce-mri, b-mode ultrasound (bmus) and strain elastography (se) images for classifying benign and malignant breast lesions.

in this retrospective study,555 breast lesions from 555 patients who underwent dce-mri, bmus and se examinations were randomly divided into training (n =388) and testing (n = 167) datasets. radiomics features were extracted from manually contoured images. the inter-class correlation coefficient (icc), mann-whitney u test and the least absolute shrinkage and selection operator (lasso) regression was applied for feature selection and radiomics signature building.nine radiomics models including four single-modality radiomics models (dce-3d, dce-2d, bmus, and se), four multi-modality radiomics models (bmus + se, dce-3d + bmus, dce-3d + se, and dce-3d+se+bmus), and the combination diagnostic model(clinical features and dce-3d+se+bmus features) were developed and evaluated by their discrimination, calibration, and clinical usefulness.

Eligibility criteria:
inclusion criteria: patients with breast lesions underwent biopsy or surgical resection between january 1, 2018 and march 30, 2024. exclusion criteria: 1. pathologicalresult of biopsy or surgical specimen was unavailable for the target lesion; 2. patients without dce-mri, bmus and se examinations before biopsy or surgery within one month; 3. patients hadperformed radiotherapy, chemotherapy, or breast biopsy before mri and ultrasound examinations; 4. patients without completedicom data for each examination; 5. patients with poor-qualityimages.
prevention of postpartum venous thromboembolism in women at intermediate risk

Conditions: Venous Thromboembolism (VTE); Post Partum Women

Summary: venous thromboembolism (vte) is currently the second cause of death in women of reproductive age worldwide. the incidence of vte during pregnancy is 1.2 to 1.4/1000 women, half of vte occurring during postpartum and as pe in majority of cases, accounting for 8.8% of maternal deaths. majority of postpartum vte occurs in women with one or more moderate risk factors (obesity, caesarean section, postpartum hemorrhage). for these women at intermediate risk, the efficacy and safety of thromboprophylaxis have not been assessed yet during postpartum and international guidelines for pharmacological thromboprophylaxis, based on data extrapolated from other populations, observational studies and small clinical trials are inconsistent across countries. we designed an open-label, randomized, controlled trial, aiming to demonstrate the superiority of a pharmacological thromboprophylaxis strategy with lmwh (lmwh type chosen according to physician / patient's preference) during 6 weeks after delivery (the 6-weeks follow-up visit being matched with usual care) in women at intermediate risk, over no pharmacological thromboprophylaxis.


Eligibility criteria:
inclusion criteria: * women at intermediate risk of vte during post-partum= with a 3% or more risk of vte based on a validated prediction model\* or international guidelines (accp 2012). * age over 18 years * delivery between 6 hours and \< 36 hours * written informed consent * definition: intermediate risk is defined as ≥ 3%, based on risk prediction model developed by sultan et al taking in account: smoking, varicose veins, obesity, comorbidities, diabetes, pre-eclampsia, post-partum hemorrhage, postpartum infection, emergency or elective section or following accp guidelines: one major risk factor or two minor risk factors. exclusion criteria: * previous personal history of vte * lmwh started during antenatal period * need for anticoagulation at curative dose * contraindication to lmwh (previous heparin induced thrombopenia, hemostatic impairment, known severe renal insufficiency) * women who received more than two doses of lmwh since delivery * unable or refusal to give informed consent * aspirin at a daily dose 100 mg or dual antiplatelet therapy * previous inclusion in mum-vte study * concomitant participation in another therapeutic study
postmenopausal pessary users: estrogen versus trimosan

Conditions: Vaginosis; Vaginosis, Bacterial; Vaginal Discharge

Summary: the purpose of the study is to compare vaginally applied estrogen with the vaginal gel trimosan for their effects on vaginal ph and vaginal symptoms in postmenopausal pessary users.


Eligibility criteria:
inclusion criteria: * postmenopausal female pessary user (ring with support pessaries only). postmenopausal will be defined as: amenorrhea for a year or 3 months after surgical bilateral salpingo-oophorectomy * is a new pessary user, or has not had a pessary for a year exclusion criteria: * pregnancy * persistent bacterial vaginosis infection in the first two clinic encounters * currently on hormone replacement therapy * previously on hormone replacement therapy in the past 6 months * currently on antibiotics * patients with existing vaginal erosions/ulcerations

Keywords: pessary vaginal ph
indocyanine green (icg) guided sentinel lymph node mapping for pediatric visceral solid tumors

Conditions: Solid Tumor

Summary: the purpose of the study is to find out the usefulness and safety of a dye called indocyanine green (icg for short). this dye will be used to help the surgeon find lymph nodes draining solid tumors inside the abdomen that need to be removed. this may also help the surgeon to find if the cancer has moved to other lymph nodes outside of the known area. primary objectives * to determine the percentage of patients in whom indocyanine green (icg)-guided sentinel lymph node (sln) mapping was successful at the time of retroperitoneal lymph node dissection for staging of visceral solid tumors. * to determine the percentage of patients with grade 3 or higher adverse events related to icg use.

during surgery, participants will be given the dye to help the doctor see the lymph nodes to be removed. pictures or a video of the procedure will be done. the number of lymph nodes removed will be recorded. after surgery, the lymph nodes will be examined. participants will be followed for up to 24 hours after surgery to determine if there were any side effects from the dye.

Eligibility criteria:
inclusion criteria: * any patient under the age of 21 years with visceral pediatric solid tumor suspected to be wilms tumor or para-testicular rhabdomyosarcoma requiring retroperitoneal lymph node dissection. exclusion criteria: * subjects with a history of iodide allergies. * inability or unwillingness of research participant or legal guardian/representative to give written informed consent. * pregnant female. * patients with extensive prior surgery at the primary site or nodal basin expected to affect the lymphatic drainage.

Keywords: indocyanine green sentinel lymph node mapping pediatric young adult
physical exercise in subjects with juvenile myoclonic epilepsy

Conditions: Epilepsy; Epilepsia; Epileptic Seizures; Seizure Disorder

Summary: epilepsy is a chronic neurologic disorder characterized by seizures. beside seizures people suffering from epilepsy experience several challenges related to education, work and everyday life such as learning-, problem-solving-, memory-, concentration-, attention difficulties and fatigue. it is generally approved that physical activity (pa) has a positive effect on physical as well as mental factors. however, people with epilepsy are found to be less active and pa is rarely offered or recommended as supplement to anti-epileptic medical treatment. few studies have investigated the effect of pa in subjects with epilepsy and additional studies of high methodical quality are needed to enable evidence-based information and counselling. this study is carried through as a randomized controlled trial which investigates the effect of participation in a 10-week cardio exercise program in people with juvenile myoclonic epilepsy aged 15-50. the study hypothesis is that participation in a 10-week cardio exercise program will induce a positive change in cognitive function (concentration and attention) and possibly in brain-derived neurotrophic factor (bdnf). in addition it is expected that the intensity and duration of the 10-week cardio exercise program is sufficient to cause changes in physiological parameters related to a reduced risk of lifestyle diseases.


Eligibility criteria:
inclusion criteria: * age: 15-50 * resident: fyen, denmark * epileptic syndrome: juvenile myoclonic epilepsy exclusion criteria: * physical handicaps which complicate participation in physical activity

Keywords: epilepsy physical activity cardio exercise physical fitness cognitive function
health promotion and cardiovascular risk reduction among people with spinal cord injury

Conditions: Spinal Cord Injuries

Summary: this study is a controlled pragmatic implementation study in clinical practice, with a primary focus on cardiovascular risk reduction through adherence to behavioral interventions related to physical activity and healthy diet.the intervention is interdisciplinary, multimodal and patient activating and uses the existing setting and work flows at the clinic, ensuring that the patients receive education about cardiovascular risk factors, physical activity and healthy diet through a systematic approach including targeted patient education.

this clinical intervention study will investigate the effectiveness of a uniform and systematic institutional strategy incorporating targeted strategic patient education about cardiovascular risk factors, physical activity and a healthy diet lifestyle starting early in the primary rehabilitation process with 6 months of follow up compared to a historic control group. test - retest reliability of four different vo2 peak tests and a multi sensor accelerometer respectively will be assessed as well.

Eligibility criteria:
inclusion criteria: * all newly injured patients (within the last 12 months) with spinal cord injury admitted at clinic for spinal cord injuries, rigshospitalet. exclusion criteria: * insufficient skills in danish language * reduced mental function that prevents reading and answering the questionnaires

Keywords: cardiovascular diseases health promotion
sentinel lymph node (sln) in colorectal carcinoma (crc) with a near-infrared (nir)-dye

Conditions: Sentinel Lymph Node; Colorectal Cancer; Metastasis

Summary: the sentinel lymph node (sln) procedure is a standard staging technique in several types of cancer. one of the major problems of sln mapping in colorectal cancer is the lack of an optimal dye and technique for identification of the nodes. in this study the investigators used the near-infrared (nir) dye indocyanin green (icg) to identify nodes with a newly developed nir laparoscope. the investigators compared two different injection techniques; subserosal and submucosal injection. patients planned for a laparoscopic resection of a colorectal carcinoma without distant metastases were included. dye was injected in the subserosa or submucosa of the bowel. ten minutes after injection the investigators searched for fluorescent nodes with the nir laparoscope. fluorescent nodes were harvested and analyzed by the pathologist using h\&e and additional immunohistochemistry.


Eligibility criteria:
inclusion criteria: * oral and written informed consent (ic) * age 18 years and older * patients histological or radiological suspicion of colon cancer * surgical resection of the tumor * regular pre-operative work-up exclusion criteria: * gross lymph node involvement * distant metastases * advanced disease with invasion of adjacent structures * prior colorectal surgery * metastatic or t4 disease discovered during intraoperative staging * contraindications to laparoscopy * rectal cancer * allergy to iodine * patients at higher risk for anaphylactic reactions

Keywords: image guided surgery
an investigation into the dispersion pattern during coughing and open nasopharyngeal suction using various barrier devices

Conditions: Airway Aspiration

Summary: the aim of the study is to examine the air dispersion pattern and the environmental influence of open airway suction in general ward setting. secondly, the study is aimed at identifying a simple \& practical enclosure device in general ward. suction will be performed in manikin in supine lying. nasopharyngeal suction will be performed by physiotherapist with working experience more than 1 years. besides, surgical mask \& enclosure tent will be adopted as the enclosure barrier device in this study. research question 1. to assess the extent of the environmental contamination during coughing and simulated airway suction 2. to measure the air particle count during coughing and simulated open airway suction. 3. to evaluate how effective the enclosure barrier in reducing the air particle dispersion during open airway suction.


Eligibility criteria:
inclusion criteria: * physiotherapists with working experience more than one year exclusion criteria: * physiotherapists with working experience less than one year
video telehealth in alzheimer's: neuropsychology (vital-np)

Conditions: Suspected Typical Alzheimer's Disease (AD); Suspected Atypical Alzheimer's Disease (AD)

Summary: the overarching goal of this study is to a) assess the feasibility and preliminary validity of home-based delivery of telenp to patients with suspected alzheimer's disease (ad), referred for cognitive assessments in a neurology clinic; and b) elucidate whether telenp is equivalent to face-to-face evaluation (ff) for diagnostic adjudication of atypical versus typical ad.


Eligibility criteria:
inclusion criteria: * individuals age 60 to 90 years who are undergoing evaluation for possible ad and whose severity ranges from mci to mild dementia. * individuals must carry a diagnosis of either suspected typical ad or atypical ad, based on the referring neurologist's diagnosis. exclusion criteria: * individuals with moderate to severe levels of dementia and individuals with active delirium (per neurologist's determination). * individuals who are legally blind or deaf, due to the auditory and visual components of the study. * individuals with a brain tumor and individuals who have a confirmed nonad neurological diagnosis (e.g, multiple sclerosis; ftd). * individuals who are being evaluated outside of the uch memory disorders clinic. * individuals who report active (i.e., within the last 6 months) substance use of illicit drugs such as cocaine or methamphetamines, or who carry a diagnosis of a major psychiatric disorder (e.g., schizophrenia; bipolar disorder).
pharmacist-led interventions to increase access to medications for opioid use disorders (pli-moud)

Conditions: Opioid Use Disorder; Overdose

Summary: the purpose of this study is to investigate the impact of a pharmacist-led intervention to expand access to medications for opioid use disorder (moud) on racial/ethnic differences in opioid-related overdose among individuals diagnosed with opioid use disorder (oud) currently incarcerated in a carceral setting. in this study, participants will be screened for opioid use, trained to administer narcan nasal spray, receive motivational counseling and referral to treatment post-release from a carceral setting (a re-entry program) into the community.

the main objectives of this study are: 1. to increase understanding of racial/ethnic differences in the prevalence of oud. 2. to test if a pharmacist-led intervention is more effective than a substance use counselor (lay person) in increasing knowledge and confidence among different racial/ethnic groups related to administering narcan nasal spray in an opioid overdose situation. 3. to test if a pharmacist-delivered an evidence-based intervention, q brief intervention and referral to treatment (birt) versus standard medication counseling (smc) is more effective in increasing access to moud.

Eligibility criteria:
inclusion criteria narcan training: * a re-entry program participant 7-14 days from release from carceral setting * provide collateral contact information for ≥2 persons (to ensure consistent contact/follow up) * have a reliable landline or mobile phone to be contacted by pharmacist * plan to remain in the little rock area for at least 6 months * able to read and write english * able to provide informed consent * possesses manual dexterity; physical ability to roll a person onto her/his/their back and side * have no allergy to naloxone hydrochloride (active ingredient in narcan nasal spray)- * identified on the rods screener as positive for oud. birt/smc: * a re-entry program participant 7-14 days from release from the carceral setting * provide contact information for ≥2 persons (to ensure consistent contact/follow -up) * have a reliable landline or mobile phone to be contacted by pharmacist * plan to remain in the little rock area for at least 6 months * able to read and write english; able to provide informed consent * identified with oud. exclusion criteria: narcan training: * not a re-entry program participant * identified substance use disorders other than oud birt/smc: * not a re-entry program participant * identified substance use disorders other than oud

Keywords: harm reduction criminal justice pharmacy practice
a multi-center, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of certolizumab pegol in combination with methotrexate in the treatment of disease modifying antirheumatic drugs (dmard)-naïve adults with early active rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: this study is intended to evaluate the efficacy and safety of certolizumab pegol (czp) in combination with methotrexate (mtx) for sustaining clinical response achieved in study ra0055 period 1 \[nct01519791\]. subjects entering this study ra0055 period 2 achieved sustained low disease activity at week 52 in study ra0055 period 1.


Eligibility criteria:
inclusion criteria: - those subjects in previous study ra0055 period 1 who are in sustained lda (defined as das28\[esr\] ≤ 3.2 at weeks 40 and 52) at week 52 in previous study ra0055 period 1 exclusion criteria: - those subjects in previous study ra0055 period 1 who are not in sustained lda (defined as das28\[esr\] ≤ 3.2 at weeks 40 and 52) at week 52 in previous study ra0055 period 1

Keywords: certolizumab pegol - cimzia rheumatoid arthritis
weekly docetaxel versus weekly docetaxel/gemcitabine in the treatment of non-small cell lung cancer in elderly patients

Conditions: Lung Cancer

Summary: in this randomized trial, we attempt to further define optimal palliative chemotherapy for elderly patients with advanced non-small cell lung cancer by comparing single agent treatment with weekly docetaxel versus combination therapy with weekly docetaxel plus gemcitabine.

upon determination of eligibility, patients will be randomly assigned to one of two treatment arms: docetaxel docetaxel + gemcitabine for ever 2 patients treated, 1 will receive treatment a (docetaxel) and 1 will receive treatment b (docetaxel + gemcitabine). the study is not blinded so both the patient and the doctor will know which treatment has been assigned.

Eligibility criteria:
inclusion criteria: to be included in this study, you must meet the following criteria: * biopsy-proven non-small cell lung cancer * no previous chemotherapy. * age \> 65 years * age \< 65 years requires significant assistance to perform activities of daily * stage iv disease or stage iiib disease * ability to perform activities of daily living with minimal assistance * measurable or evaluable disease * adequate bone marrow, liver and kidney * all patients must sign written informed consent prior to study entry. exclusion criteria: you cannot participate in this study if any of the following apply to you: * brain metastases * meningeal metastases * other uncontrolled malignancies * history of invasive cancer during the last 5 years * moderate to severe peripheral neuropathy please note: there are additional inclusion/exclusion criteria. the study center will determine if you meet all of the criteria. if you do not qualify for the trial, study personnel will explain the reasons. if you do qualify, study personnel will explain the trial in detail and answer any questions you may have.
biomarkers in retinitis pigmentosa (birp)

Conditions: Retinitis Pigmentosa

Summary: in this study, markers of oxidative stress will be measured in the aqueous humour and plasma of rp patients compared to controls.

people with retinitis pigmentosa have loss of night vision followed by loss of central vision due to damage and death of photoreceptors. one of the mechanisms causing damage is high levels of oxygen in the eye. this damage produces specific biomarkers which can be measured. in this study, these biomarkers will be assessed in people with retinitis pigmentosa and compared to controls.

Eligibility criteria:
inclusion criteria: * signed informed consent and authorization of use and disclosure of protected health information * age more than or equal to 18 years * for the study group, patients diagnosed with retinitis pigmentosa by the investigators * for the control group, patients undergoing vitreoretinal surgery for macular hole, epiretinal membrane, vitreomacular traction, retinal detachment, neovascular age-related macular degeneration (amd) and diabetic retinopathy will be eligible exclusion criteria: * patients with active or suspected ocular or periocular infection

Keywords: rp