Kornimate/medical-research-clean huggingface dataset:
study on pancreatic islets in patients undergoing (partial) pancreatectomy (precise)

Conditions: Diabetes Mellitus

Summary: the study investigates the mechanisms underlying the pathogenesis of diabetes by examining structural and functional properties of islets of langerhans in pancreas specimen from patients undergoing (partial) pancreatectomy.

the study aims at elucidating the mechanisms underlying the pathogenesis of diabetes. in particular, the study focusses on detailed analyses of morphological and functional properties of pancreatic islets/insulin-producing beta cells in order to identify diabetes-associated alterations on cellular and molecular levels. to directly address the role of the endocrine (and exocrine) pancreas in the complex process of diabetes development, the examinations are performed in samples of human pancreatic tissue. to this end, biopsy specimen of pancreas and visceral adipose tissue are collected from patients with or without diabetes who undergo (partial) pancreatectomy. the samples are analysed for morphological alterations (e.g. size and distribution of pancreatic islets and beta cells, size of adipocytes) and functional changes (e.g. gene expression patterns as assessed from beta-cell derived rna). in addition, patient characteristics such as age and disease duration are documented and clinical data including fasting concentrations of blood glucose, insulin and free fatty acids are collected. specific diabetes-associated alterations of pancreatic islet / beta cells are assessed by associating variables of glucose- and lipid-homeostasis with parameters of beta cell function. the expected outcomes of the study will contribute to improve our knowledge of the so far largely unknown molecular and cellular mechanisms involved in the pathogenesis of diabetes.

Eligibility criteria:
inclusion criteria: ability to give informed consent exclusion criteria: denial of informed consent
culturally adapted psychological intervention for bipolar disorder in pakistan

Conditions: Bipolar Disorder

Summary: aim: to assess the feasibility rct of the efficacy of a culturally adapted psychological intervention for bipolar disorder in pakistan design: randomized control trial setting: psychiatric departments of different hospitals in karachi. participants: a total of 36 bipolar disorder patients will be randomized to psychological intervention and treatment as usual arm. intervention: culturally adapted psychological intervention for bipolar disorder outcome measure: * acceptance of intervention in terms of attending session and dropouts * knowledge and attitudes towards bipolar disorder

the purpose of the study is to test feasibility rct of the efficacy of a culturally adapted psychological intervention for bipolar disorder in pakistan primary objectives : 1. to determine effectiveness of educational intervention in terms of patient satisfaction with overall care, knowledge and attitudes to bipolar disorder and medication adherence. 2. to assess feasibility in terms of * recruitment * using instruments that will be used to assess recurrence rate in the main study (bdi, ymrs and obtaining prospective hospitalisation and medication data) * acceptability of a culturally adapted bipolar group education package 3. to allow 'fine tuning' of culturally adapted bipolar group education package (this will partly be achieved by using the semi at study entry) the participants will be recruited from psychiatric department of different hospitals. they will be randomly divided into two groups; intervention group and treatment-as-usual group. a total of thirty six participants will be recruited in the pilot study and divided equally into two arms. this will ensure that, even after loss to follow-up, we will have at least 12 subjects per group for analysis (fda guidance http://www.fda.gov/cder/guidance/5356fnl.pdf) .randomization will be carried out by the on offsite statistician. this will provide a reliable geographically remote service. for intervention group twelve sessions of psychoeducation will be provided by trained research clinician during the period of three months. patients in the treatment as usual (tau) group will be given details of intervention at the end of the study and interested patients will be offered psychoeducation.

Eligibility criteria:
inclusion criteria: * diagnosis of dsm iv bipolar disorder * currently stable (ymrs \<8, bdi\<12) * age 18 to 65 years. * participants engaged with the mental health services since last 6 months. * able to give written informed consent. * resident of trial catchments area * ability to speak urdu /punjabi exclusion criteria: * substance or alcohol dependent (i.e., those who fulfill the criteria for dependence according to dsm iv criteria) * inability to engage fully in the psychotherapy (due to cognitive impairment) * actively suicidal * any major psychiatric illness other than bipolar disorder

Keywords: psycho-education, bipolar , cultural adaptation, pakistan
post marketing study for the evaluation of predictix antidepressant clinician software support tool in prescribing antidepressant medication/s for the treatment of patients suffering from major depressive disorder

Conditions: Major Depressive Disorder

Summary: the study is designed as an open label, one arm study. up to 30 eligible patients will be enrolled, for whom the predictix antidepressant software tool will be used when prescribed with a medication for their major depressive disorder, by their treating physician. visits will include the completion of several questionnaires designed to answer the study objectives, either as self-reported by the subjects and/ or by the clinician.

the study will enroll up to 30 eligible patients, for whom the predictix antidepressant software tool will be used when prescribed with a medication for their major depressive disorder, by their treating physician. a treatment cycle will include four to five visits: information consent and oral sampling, baseline, 4 and 8 weeks. at least one completed cycle per patient is required for a patient to be included in the analysis as study completed. the treating physician will review and approve each subject's eligibility prior to his/ her entrance to the study and will review the predictix antidepressant software tool report prior to treatment start. visits will include the completion of the taliaz ltd. physician form and several questionnaires designed to answer the study objectives usability and satisfaction questionnaire/s will be analyzed for usefulness, satisfaction, ease of use and learnability of the system.

Eligibility criteria:
inclusion criteria: * male and female at the age of 18 - 75 years old * indication of mdd diagnosis per dsm v * rule out other causes of depressive symptoms other than mdd apart from general anxiety disorder as authentified by the mini\*) (by sheehan and lecrubier ). \*up to a maximum of 15 completed gad pts * ability to read, understand and sign an informed consent document exclusion criteria: * patient is diagnosed with other major psychopathologies (i.e. schizophrenia, bipolar disorder, psychotic depression, geriatric depression) * patient requires antipsychotic medication or mood stabilizers * patient is at substantial suicidal risk as judged by the treating physician * patient has attempted suicide in the past year. * patient has any current unstable medical condition or surgical illness * patient has history of seizure or convulsions. * patient has history of drug abuse or alcoholism in the last 6 months * inadequate communication with the patient * in the investigator's judgement, patient is not able to provide written informed consent * pregnant women
the psychological, social, and economic impacts of covid-19

Conditions: COVID-19; Chronic Disease; Psychiatric Disorder; Cardiovascular Diseases

Summary: a dynamic analytical tool is being implemented to monitor the health, psychosocial and economic impacts of the covid-19 pandemic as the crisis unfolds. a longitudinal survey is distributed via a network of hospitals, provincial/national organizations and web platforms. the survey information can be linked to provincial health administrative data and metrics derived from social media activity based on artificial intelligence methods. targeted questions are included for critical populations such as healthcare workers and people with chronic illnesses.

the current situation unfolding with regards to the covid-19 virus is changing core aspects of people's lives in a unique manner. this study aims to examine the psychological, social, and financial impacts of the covid-19 pandemic at various stages of the outbreak. individuals 12 years and older are recruited from three main groups: general population, people with chronic illnesses and healthcare professionals. an online survey is distributed via multiple hospitals, provincial/national organizations, and web-based platforms at various phases of the outbreak. the survey includes validated questionnaires and custom-made questions to asses the current situation. it notably addresses the following themes: demographics, covid-19 symptoms and diagnoses, social distancing practices and social interactions, living situation, financial situation, family and work-related challenges, access to healthcare, as well as sleep, physical and mental health. the survey is available in english and french. it is built on a decisional tree structure with customized subsets of questions based on previous answers.the survey contains an adolescent version and an adult version, and also includes targeted questions for individuals with a current diagnosis of a mental/medical illness. consent is also sought to link data from parent-child dyads to enable finer analyses of family dynamics. healthcare staff are invited to answer questions about work-related difficulties, usefulness of virtual tools for clinical practice, as well as moral distress and moral resilience in the context of clinical practice. healthcare staff who are short on time can chose fill out an abbreviated version. participants have the option of enabling linkage to linked to provincial health administrative data, and to provide their twitter and facebook handle for social media and mood monitoring through artificial intelligence algorithms. participants have the option of being followed longitudinally during and after the outbreak.

Eligibility criteria:
inclusion criteria: * all individuals who are at least 12 years of age exclusion criteria: * none

Keywords: covid-19 pandemic psychology social interactions financial impacts mental health stress anxiety depression healthcare professional's health familly sleep occupational life survey social media access to care social distancing
open abdomen: vacuum pack versus sylo bag and mesh protocol

Conditions: Open Abdomen; Temporary Abdominal Closure Mechanisms

Summary: the open abdomen is a valid and accepted surgical tactic for the trauma and acute care patient. there have been many mechanisms described for its management, but the most accepted strategy is the vacuum pack. at our hospital the investigators have used for many years a double sylo bag, one underneath the fascia and the other sutured to the skin, at the initial operation. at subsequent surgeries once the abdomen is clean the investigators leave the same subfascial sylo bag and use a prolene mesh attached to the fascia. every day the investigators try to tighten the mesh with sutures until the abdomen can be closed. this study´s objective is to compare our double sylo bag- mesh protocol with the vacuum pack to determine which is related to a higher fascial closure rate.

the investigators plan to compare our double sylo-mesh protocol with the vacuum pack technique described by barker et al. to accomplish this they have designed a randomized trial that will include patients that require an open abdomen strategy according to their attending physician either due to a traumatic or a medical cause. once the surgeon decides to leave the abdomen open, one of the nurses will pick up an envelope from the randomization box and read out loud the patients allocation (vacuum pack or double sylo bag-mesh protocol) . during subsequent surgeries the patient must continue with the same strategy for a minimum of 21 days or until fascial closure. the patients will be followed during their whole hospital stay to determine complication rates and fascial closures.

Eligibility criteria:
inclusion criteria: * open abdomen exclusion criteria: * patients that die in the first 48 hours after the initial intervention

Keywords: open abdomen negative pressure wound therapy temporary abdominal closure mesh abdominal reconstruction
low-carbohydrate diet intervention on body weight

Conditions: Over Weight; Obesity

Summary: * the primary aim of this study is to determine the adherence of low- carbohydrate among chinese. * then compare the effect of low-carbohydrate and traditional chinese but restricted-calories diet on weight loss and metabolic traits.

obesity is a well established risk factor for type 2 diabetes mellitus, hypertension, dyslipidemia and cardiovascular disease. along with rapid nutritional and lifestyle transition featured as increased energy dense diet intake and reduced physical activity, the prevalence of obesity has reached epidemic level and affected more than 70 million chinese adults nowadays. previous studies suggested that low-carbohydrate diet was an effective and safe way to lose weight and had potential benefit on lipids profiles. however, it is still unknown whether this diet can be feasible to control the epidemic of obesity and its related metabolic diseases among chinese, whose carbohydrate consumption contribute approximately 55% of total energy intake. therefore, the aim of this pilot study is to investigate the adherence and effectiveness of two weight-loss diets among chinese. this will be a randomized, controlled clinical trial. a total of 50 overweight or obese nurse assistants will be randomly assigned to receive a low-carbohydrate diet or a traditional high-carbohydrate chinese but restricted-calories diet for 12 weeks. the adherence of study protocol and effects of the two diets on body weight, waist circumference, body fat, fasting glucose and lipid profile will be evaluated.

Eligibility criteria:
inclusion criteria: * overweight/obese (bmi ≥24 kg/m2) exclusion criteria: * pregnancy or lactation; * serum creatinine and blood urea nitrogen level beyond the clinical reference value; * alanine aminotransferase and aspartate aminotransferase beyond the reference levels; * gastrointestinal problems that would prevent them from complying with the specified feeding conditions; * received gastrointestinal surgery (except for appendicitis or hernia); * severer cvd; * active cancer; * mental diseases, epilepsia or using anti-depression drugs; * participating in other scientific studies within 3 months before the study.

Keywords: over weight obesity
interest of animal-assisted therapy with dogs in the treatment of depression

Conditions: Depression

Summary: this study is a randomized controlled trial (comparing "occupational activities" versus "dog-assisted therapy" arms) investigating the effectiveness of animal-assisted therapy with dogs in small groups of participants with depression. patients in the "dog-assisted therapy" arm will participate in two group sessions (groups of 3 to 7 participants) of canine-assisted therapy, supervised by a healthcare professional certified in animal-assisted therapy alongside a psychiatric caregiver, for 30 minutes each week over 6 weeks. patients in the "occupational activities" arm will participate in two group sessions (groups of 3 to 7 participants) of occupational activities, supervised by a healthcare professional experienced in group occupational activities alongside a psychiatric caregiver, for 30 minutes each week over 6 weeks.


Eligibility criteria:
inclusion criteria: * patient aged 18 to 65 * patient affiliated with a social security scheme * patient hospitalized under voluntary psychiatric care * diagnosis of depression according to dsm-5-tr criteria * qids-c16 score ≥11 at screening * qids-sr16 score ≥11 at screening and inclusion exclusion criteria: * severe comorbid psychiatric disorder * imminent risk of suicidal behavior * unstable comorbid somatic condition * vulnerable patients (under guardianship, curatorship, or judicial protection) * known fear of dogs * known allergy to dog fur

Keywords: depression dog-assisted therapy
non-invasive brain tumor molecular diagnostics and monitoring

Conditions: Brain Tumor

Summary: this prospective multicenter study aims to enroll gbm patients who will undergo repeated assessments (preoperatively and 3 months post-surgery) to detect circulating tumor cells and analyze the transcriptomic profiles of evs in their blood. the prognostic and monitoring significance of these biomarkers to disease course (assessing treatment efficacy, resistance incidence, tumor progression) will be evaluated. concurrently, proteomic profiles typical of gbm will be analyzed in blood and ocular secretion samples from gbm patients, patients with low-grade gliomas, and patients without brain tumors to identify and validate novel protein biomarkers suitable for disease monitoring. additionally, this study proposes an innovative approach to monitor gbm patients by investigating the presence of gbm-specific nucleic acid fragments in urine.


Eligibility criteria:
inclusion criteria: adult patients with brain tumors - exclusion criteria: no other cancer; no inflammatory disease -
dynamic ctdna-guided targeted therapy in dlbcl

Conditions: Diffuse Large B Cell Lymphoma (DLBCL)

Summary: this is a prospective, single-arm, noninferiority trial involving patients with previously untreated cd20-positive dlbcl. the aim of this study is to determine the efficacy and safety of treatment stratified based on ctdna dynamic changes after one cycle of chemotherapy and the targeted therapy based on dlbcl genotype. a total of 108 patients were planned to be enrolled in this trial, and the patients were stratified according to the dynamic changes of ctdna after one cycle of chemotherapy: the chemotherapy-sensitive group continued the original r-chop regimen, and the potential drug resistance group received genotype-guided targeted drug combination. the whole trial included a screening period (day -28 to day -1), a treatment period, and a 2-year follow-up period.


Eligibility criteria:
inclusion criteria: * signed informed consent form * age 18-75 years at the time of signing informed consent form and willingness to comply with study protocol procedures * previously untreated participants with cd20-positive dlbcl * ipi score 2-5 * ecog performance status of 0, 1, or 2 * life expectancy ≥ 6 months exclusion criteria: * contraindication to any of the individual components of r-chop or obutinib or decitabine or lenalidomide or chidamide * have received systemic or local treatment including chemotherapy in the past * have received autologous stem cell transplantation in the past * past medical history of other malignant tumors, except basal cell carcinoma of the skin and cervical cancer in situ * accompanied by uncontrolled cardiovascular and cerebrovascular diseases, coagulopathy, connective tissue diseases, severe infectious diseases and other diseases * primary central nervous system lymphoma * left ventricular ejection fraction ≦50% * other concurrent and uncontrolled situation which will affect the patient's medical status based on researchers' decision * any of the following abnormal laboratory values (unless any of these abnormalities are due to underlying lymphoma): * anc \< 1.0 x 10\^9/l * plt \< 75 x 10\^9/l * hb \< 100g/l * serum ast and alt ≥ 2.5 x uln * total bilirubin ≥ 1.5 x uln * serum creatinine ≥ 1.5 x uln * psychiatric patients or other patients who are known or suspected to be unable to fully accomplish with the research protocol * pregnant or lactating women * patients with positive hbsag test results need to undergo hbv-dna test and can be admitted to the group after turning negative. in addition, if the hbsag test result is negative, but the hbcab test is positive (regardless of the hbsab status), hbv-dna is also required；if the result is positive, patients also need to be treated to become negative before entering the group * patients living with hiv
virtual reality glasses and stress ball on distress and pain arteriovenous fistula cannulation

Conditions: Hemodialysis Complication

Summary: effects of virtual reality glasses and stress ball on distress and pain during arteriovenous fistula cannulation. the research was conducted as a randomized experimental study with a pre-test - post-test control group.

beginning 1-2 minute before the start of the procedure, the patients will be watched (5 minutes) with an android mobile phone inserted into the cardboard super flex binoculars glasses. a stress ball will be applied to the patient 1-2 minutes before the start of the procedure.

Eligibility criteria:
inclusion criteria: * be over 18 years old, * be able to speak and understand turkish, * have the cognitive ability to answer the data collection tools, * be willing to participate in the study, * participate in a hemodialysis program three days a week, exclusion criteria: * having a communication problem (hearing, language, understanding, etc.), * having a psychiatric diagnosis (to be checked from medical records), * having failed avf cannulation at the first attempt, * having any signs of infection such as redness, swelling, open wound in the area where the procedure will be performed, * having used a sedative within the last 8 hours, * having used any painkillers before the procedure on the same day,
rivaroxaban evaluation in real life settings

Conditions: Atrial Fibrillation; Stroke

Summary: to discover outcomes of patients treated with rivaroxaban with atrial fibrillation with at least one additional investigator-determined risk factor for stroke in real-life practice.

this large global registry focuses on studying atrial fibrillation (af) and evaluating characteristics, management and outcomes of patients treated with rivaroxaban. the river registry is observational, decisions on patient management are determined by the health care professional and the patient and not by the protocol. patients are therefore treated according to normal local practice and the drug label/relevant product information of any drugs administered to them.

Eligibility criteria:
inclusion criteria: * written informed consent * age 18 years and over * new diagnosis of non-valvular atrial fibrillation (diagnosed within the last 6 weeks) with at least one additional investigator-determined risk factor for stroke * initial treatment with rivaroxaban following af diagnosis exclusion criteria: * no further follow-up envisaged or possible within enrolling hospital or with associated primary care physician. * patients with transient af secondary to a reversible cause. * patients participating in an interventional study that dictates treatments, visit frequency or diagnostic procedures * not treated with rivaroxaban as first treatment

Keywords: atrial fibrillation rivaroxaban stroke
antibiotics management of septic neutropenic patients in the intensive care unit

Conditions: Neutropenia, Febrile

Summary: neutropenia, defined by an absolute count of polymorphonuclear neutrophils less than \<1500/mm3, exposes patients to infectious complications that can lead to sepsis or septic shock. the mortality risk is higher risk. the recommendations published in 2016 were formulated to homogenize the clinical practices to improve the survival.

we evaluate the adequacy antibiotics prescriptions in febrile neutropenia with suspected infection and evaluate factors influencing adequacy therapy and mortality consequence.

Eligibility criteria:
inclusion criteria: * sepsis or septic shock at admission or during the stay exclusion criteria: * minor * pregnancy * opposition