Kornimate/medical-research-clean huggingface dataset:
immersive healing: the therapeutic potential of virtual reality

Conditions: Phantom Limb Pain (PLP)

Summary: phantom limb pain (plp) is a significant and pervasive issue among upper limb amputees, severely impacting their quality of life. the literature delineating prevalence of upper versus lower limb amputations is limited, but the prevalence of total amputations in the united states is estimated to reach 3 million individuals by 2050, with approximately 185,000 new cases annually. plp affects 60-68% of these patients, leading to heightened levels of anxiety, depression, and reduced overall well-being.

although studies exploring the efficacy of vr therapy for plp have reported positive outcomes, several limitations, such as small sample sizes, lack of randomization, and inconsistent treatment protocols, have impeded widespread adoption of these innovative approaches. additionally, the literature does not sufficiently delineate which aspects of the phantom limb experience may be addressed with vr therapy. to overcome these limitations and optimize treatment efficacy, it is crucial to gain a comprehensive understanding of the phantom limb experience, including both somatosensory and kinesthesia-related symptoms. additionally, this study will address these limitations by employing a larger sample size, rigorous methodology, and a standardized treatment protocol.

Eligibility criteria:
inclusion criteria: * history of major limb amputation * age \> 18 years old * presence of phantom limb pain or negative phantom sensation(s) exclusion criteria: * active mental illness, neurological disease, or cognitive impairment that would interfere with survey completion * those without phantom limb pain or negative phantom limb sensations * non-english speaking

Keywords: amputee pain management virtual reality (vr) therapy
metric properties of de morton mobility index

Conditions: Musculoskeletal Diseases

Summary: metric properties (convergent validity, predict validity, known-groups validity, responsiveness, floor and ceiling effects, minimal clinically important difference) of the de morton mobility index (demmi) in patients with musculoskeletal impairments undergoing impatient rehabilitation will be investigated.

convergent validity of demmi will be assessed in terms of correlations with the other outcome measures. known-groups validity will be demonstrated by differences in demmi scores between patients who were not able to walk and those who were able to walk with or without walking aid. predictive validity of demmi at admission for functional independence at discharge from rehabilitation will be estimated. the minimal clinically important difference of demmi, responsiveness and floor or ceiling effects will also be estimated.

Eligibility criteria:
inclusion criteria: * admission to inpatient rehabilitation * written informed consent exclusion criteria: * associated impairments of the central nervous system or other severe health conditions

Keywords: demmi outcome measurement physiotherapy clinimetric properties
assessment of quality of life in food allergic children

Conditions: Food Allergy

Summary: the purpose of this study is 1. to validate in french quality of life questionnaires for food allergic children 2. to evaluate if the quality of life of food allergic french speaking children aged 0-12 years is affected by their condition 3. to validate a didactic game for food allergic children


Eligibility criteria:
inclusion criteria: * french speaking children with confirmed ige mediated food allergy * aged 0-12 years old exclusion criteria: * inclusion in another trial * chronic severe diseases

Keywords: children aged 0-12 years ige mediated food allergy
factors correlated with fatigue in breast cancer

Conditions: Newly Diagnosed Breast Cancer; Surgery Programmed

Summary: the aim of this study is to identify the determinants of cancer-related fatigue, and the long-term effect of the different adjuvants treatments will be explored. a prospective longitudinal study in women diagnosed for the first time with stage i-iii breast cancer and who have undergone surgery, has been designed to meet the study aims.


Eligibility criteria:
inclusion criteria: * aged 18 years and older * newly diagnosed with stage i-iiia breast adenocarcinoma * have undergone surgery * who performance status score equal or lower than 2 * able to provide informed consent * speak french and able to complete self-report questionnaires exclusion criteria: * pregnancy * bilateral breast cancer * metastatic breast cancer * patients who received neoadjuvant chemotherapy * known psychiatric disease or dementia * no previous history of cancer

Keywords: breast cancer fatigue adjuvant chemotherapy quality of life
prehospital air medical plasma trial

Conditions: Hemmorhagic Shock During Air Medical Transport

Summary: to determine the effect of the prehospital infusion during air transport of 2 units of ab plasma on 30 day mortality in patients with hemorrhagic shock as compared to conventional care.

background: although advances in the care of the severely injured patient have occurred over the last decade, patients continue to be plagued with uncontrolled hemorrhage resulting in significant early mortality and the development of multiple organ failure and associated complications. a primary driving force for this unbridled hemorrhage has been shown to be the early coagulopathy which complicates severe injury. increasing evidence suggests that blood component transfusion protocols that address this early coagulopathy, once a patient arrives at a trauma center, are associated with lower mortality and a reduction in blood component transfusion requirements. prehospital interventions which quell this early coagulopathy in an earlier setting have the potential to minimize or even prevent this vicious hemorrhagic cascade, further lowering blood component transfusion requirements and reducing the resultant morbid sequelae which complicates severe injury. objective/hypothesis: the primary hypothesis will be that prehospital infusion of plasma during air medical transport in patients with hemorrhagic shock will lower 30 day mortality. the secondary hypotheses include that prehospital infusion of plasma will reduce 24 hour blood transfusion, multiple organ failure, nosocomial infection, and acute lung injury, reduce or prevent the early coagulopathy as demonstrated by improving presenting coagulation and thromboelastography parameters, and reduce the early inflammatory cytokine response, thrombomodulin and increase protein c levels.

Eligibility criteria:
inclusion criteria: hemorrhagic shock not responsive to crystalloid infusion - exclusion criteria: isolated fall, cervical cord injury, prisoner, pregnant patient, traumatic arrest -

Keywords: hemmorhagic shock, plasma, air medical transport, randomized, multicenter
prospective comparison between different laser settings for ureteral \ kidney stones treatment during ureteroscopy

Conditions: Ureterolithiasis; Nephrolithiasis

Summary: a prospective study comparing different laser settings used for stone fragmentation during ureteroscopy

two groups prospectively randomized for different laser settings during ureteroscopy one aimed for stone dusting, the other for stone fragmentation and basket extraction of fragments

Eligibility criteria:
inclusion criteria: * patients who are planned for ureteroscopy \\ retrograde intra renal surgery (rirs) for stone treatment exclusion criteria: * known ureteral stricture * severe immune deficiency * patients after urinary diversion surgery * patients with single \\ ectopic\\ implanted kidney * double collecting system * severe thrombocytopenia * patients taking anticoagulant drugs that cannot be stooped before the operation

Keywords: ureteroscopy
serratus anterior block for video-assisted thoracoscopic surgery

Conditions: Pain, Postoperative

Summary: ultrasound-guided sapb is a facial plane block which maintained analgesia with blockade of lateral branches of intercostal nerves at above or below serratus plane muscle. there are few cases and studies in the literature reporting successful analgesia provided by sapb in vats operations. the serratus plane block is used in our clinic for postoperative analgesia in vats operations. the aim of this study was to evaluate the postoperative pain scores and use of analgesia in patients performed with the serratus plane block in vats operations in a 1-year period.

approval for the study was granted by the clinical research ethics committee and all procedures were carried out in accordance with the helsinki declaration. a retrospective examination was made of the anesthesia forms of patients underwent vats may 2016 and june 2017. due to incomplete data of 1 of these 35 patients, that case was excluded from the study. the patients were divided into two groups. 24 patients were performed sapb and iv pca (intravenous patient controlled analgesia) and 10 patient's pain management were provided with only pca. no block was administered to 10 patients because of anticoagulant therapy and patient refused block application. the demographic data of the patients (age, gender, operation type, and duration) were obtained from the anesthesia forms. the postoperative pain scores of the patients, evaluated with a visual analog scale (vas) at 1, 6, 12 and 24 hours postoperatively and the postoperative doses of analgesia used were taken from the block pain follow-up forms

Eligibility criteria:
inclusion criteria: vats( video-assisted thoracoscopy) operation a.serratus anterior plane block b.patient controlled analgesia exclusion criteria: missing data written consent

Keywords: pain, vats
effect of xuebijing in alleviating acute kidney injury after high-voltage electrical burns

Conditions: Acute Kidney Injury

Summary: high-voltage electrical burns frequently lead to acute kidney injury (aki), a severe complication with high mortality. this study investigated the clinical efficacy and safety of xuebijing injection, a traditional chinese medicine preparation, in alleviating aki in patients with high-voltage electrical burns. the study hypothesized that xuebijing could improve renal outcomes by inhibiting neutrophils, inflammatory cells, and modulating reactive oxygen species (ros). this was a randomized, open-label, controlled clinical trial conducted at the third hospital of hebei medical university. ninety-six adult patients admitted between february 2023 and december 2024 with aki secondary to high-voltage electrical burns (burn area \>30% tbsa or third-degree burns \>10% tbsa, meeting aki diagnostic criteria) were enrolled. patients were randomized (1:1) into two groups: a study group (n=48) receiving conventional treatment plus xuebijing injection (50 ml diluted in 100 ml 0.9% sodium chloride, iv drip, twice daily for 7 days), and a control group (n=48) receiving conventional treatment alone. laboratory personnel assessing outcomes were blinded to group allocation where feasible. primary outcomes included changes in kidney function markers (blood urea nitrogen \[bun\], serum creatinine \[scr\], 24-hour urinary protein), inflammatory markers (neutrophils, c-reactive protein \[crp\], interleukin-18 \[il-18\], interleukin-6 \[il-6\]), and oxidative stress markers (superoxide dismutase \[sod\], malondialdehyde \[mda\]). these were measured at baseline (1 hour before treatment) and 7 days post-treatment. adverse reactions were also monitored.


Eligibility criteria:
inclusion criteria: 1. burns caused by high-voltage electrical injury, with a serum creatinine (cr) level increase of at least 26.5 μmol/l within 48 hours, or urine output less than 0.5 ml/(kg•h) sustained for 6 hours, or a cr level rising to 1.5 times the baseline within 7 days. 2. burn area greater than 30% of the total body surface area (tbsa), or third-degree burns covering more than 10% of the tbsa. 3. all patients were admitted within 24 hours of the burn injury and survived for at least 14 days post-admission. 4. all patients were aged ≥18 years. exclusion criteria: 1. radiation exposure or nephrotoxic drug exposure within 5 days prior to admission. 2. pre-existing aki at any stage, according to kdigo criteria. 3. chronic kidney disease for any reason, with a glomerular filtration rate (gfr) ≤ 60 ml/(min•1.73 m²) for at least 3 months. 4. post-kidney transplant patients. 5. patients who had received or required continuous renal replacement therapy (crrt) within 7 days. 6. anuria (urine output \<100 ml/d) preventing sample collection. 7. patients with malignant tumors. 8. patients with autoimmune diseases requiring long-term steroid therapy. 9. patients who had received high-dose steroid treatment within the past month.

Keywords: acute kidney injury xuebijing neutrophils inflammatory cells
satiation study with children attending a tertiary feeding clinic

Conditions: Undernutrition; Underweight

Summary: this is a pilot study of children attending the glasgow feeding clinic (gfc) which looks after children with severe feeding problems who commonly have low appetite and extreme thinness. the investigators want to find out if thin children respond to food in the same way, using an established method to assess energy compensation.

thinness occurs as a result of undereating, but it is not always clear why an individual child has not eaten enough, or how to get them to eat more. there is a need to understand the child characteristics that predispose to undereating and the how these operate, in order to design more effective treatment and prevention programmes. the glasgow feeding clinic (gfc) looks after a range of children with severe feeding problems who commonly have low appetite and extreme thinness. a ghanaian student will come to glasgow, funded by the glasgow university /scottish funding council global challenges research fund, to learn these techniques to use in future phd research. the student will conduct a pilot study of children attending the gfc. the student will invite 40 families to complete our standardised online questionnaire (icfet) about their child's eating behaviour and collate existing growth measurements as well as their feeding history. a standardised energy compensation study will then be undertaken in 20 of the thinnest children. at two visits at least a week apart, the children will be given one of two similar tasting drinks in random order, one with very few calories and another with extra, without them knowing which is which. after 30 minutes they will eat as much as they want of a standardized lunch. all foods and drinks offered will be weighed before and after, to calculate the amount of energy eaten in total after the low energy drink, compared to the high energy drink.

Eligibility criteria:
inclusion criteria: * currently attending glasgow feeding clinic or seen within the last 2 years. * completed icfet questionnaire and eating solid food at least weekly. * body mass index \< 9th centile. * within 40 minutes car travel from study centre exclusion criteria: * patient or family member shielding from covid. * not able to swallow safely * not taking solid foods * fully tube fed: i.e. receiving more than 75% of energy requirements from tube feeding. no measurements
levetiracetam in central pain in multiple sclerosis(ms)

Conditions: Multiple Sclerosis

Summary: multiple sclerosis is often associated with pain. there is no standard treatment of this type of pain. levetiracetam is a new anticonvulsant and it is the hypothesis that it could relieve central pain in multiple sclerosis. this is a randomised, double-blind, placebo-controlled, cross-over trial on the effect of levetiracetam 3000 mg daily on pain in multiple sclerosis.


Eligibility criteria:
inclusion criteria: * ms diagnosis verified * age \> 18 years * central pain symptoms for more than 3 months * central pain diagnosis confirmed by neurological examination * adequate anticonceptive treatment for women with child bearing potential * informed consent * baseline pain of more than 4 on numeric rating scale exclusion criteria: * other cause of pain * previous allergic reaction towards levetiracetam * known adverse drug reaction on levetiracetam * pregnancy * severe disease * inability to follow study protocol * treatment with antidepressants, other anticonvulsants or opioids

Keywords: multiple sclerosis central pain levetiracetam
gaitbetter: motor and cognitive training for gait rehabilitation and falls prevention in stroke survivors.

Conditions: Stroke; Gait, Hemiplegic; Hemiplegia

Summary: in this research study, the investigators aim to test the usability and efficacy of the gaitbetter system for gait rehabilitation after stroke.

this study consists of 3 distinct aims: in aim 1, the investigators will evaluate clinical acceptance of the gaitbetter solution by subjects and therapists. to do so, the investigators will run a pilot study to gather feedback from stakeholders (not reported here). in aim 2, the investigators will evaluate the efficacy of using the gaitbetter solution to improve motor-cognitive function of chronic stroke survivors. to do so, the investigators will run a single-arm, non-randomized study to test the hypothesis that the gaitbetter training is effective in improving gait and cognition in individuals with chronic stroke. in aim 3, the investigators will explore the efficacy of using the gaitbetter solution for improving rehabilitation outcomes in sub-acute stroke survivors. to do so, the investigators will run a randomized, controlled study to evaluate the effects of using the gaitbetter system in patients with subacute stroke on recovery trajectory.

Eligibility criteria:
inclusion criteria: * male and females of age between 18 to 85 year of age * history of one-sided ischemic or hemorrhagic stroke * chronic: more than 6 months post-stroke (aim 1 and aim 2) * subacute: within 8 weeks post-stroke (aim 1 and aim 3) * residual functional impairment of a lower extremity as a result of the stroke * ability to walk at least 15 meters with or without assistive devices (fim walk subsection, levels 6 and 7) * ability to walk 3 consecutive minutes (5 minutes for aim 2) on a treadmill at a speed equal to or greater than 0.22 m/s (0.8 km/h or 0.5 mph) with or without hand support. * medical clearance received from treating physician to participate in the gait training program proposed in the study exclusion criteria: * severe aphasia limiting the ability to express needs or discomfort verbally or non-verbally * cognitive impairment limiting the ability to understand and follow instructions (as assessed by a score \<23 on the mini mental state examination) * previous diagnosis of neurological diseases other than stroke * recent history of lower extremity fractures (\<12 months ago), unhealed wounds * current indication for isolation precautions (e.g. mrsa, vre, c. difficile, and others) * severe visual impairments (as assessed by the nih stroke scale visual field subscale. score \>0) * hemispatial neglect (as assessed by the line bisection test) * subjects diagnosed with a medical condition that would interfere with their participation in regular sustained exercise (such as a severe pulmonary and/or cardiovascular condition) * for aim 2: currently participating in a gait training intervention (pt or research) * adults with impaired decision-making capacity * women who are pregnant

Keywords: stroke gait falls
validation of the russian and kazakh versions of the beck depression inventory and beck anxiety inventory

Conditions: Depression; Anxiety; Breast Cancer; Ovarian Cancer; Cervical Cancer; Lung Cancer; Colon Cancer

Summary: depression and anxiety in female patients with cancer are serious comorbidities that affect the quality of life for patients and their survival rates as they have poorer health outcomes. this validation study is a part of the study on the prevalence of depression and anxiety among breast cancer patients. this study aims to investigate the validity of the kazakh and russian versions of the beck depression inventory (bdi-ii) and beck anxiety inventory (bai) among female cancer patients in almaty, kazakhstan.


Eligibility criteria:
inclusion criteria: * adult female patients between 18 and 65 years of age with a primary diagnosis of breast cancer; ovarian cancer; cervical cancer; colon cancer; lung cancer; * russian or kazakh language fluency; * consent to participate; exclusion criteria: * history of diagnosed depression or anxiety; * current use of antidepressants; * referral to palliative care

Keywords: depression anxiety breast cancer validation study female cancer patients
in-office evaluation of two toric soft contact lenses and a spherical soft contact lens

Conditions: Astigmatism

Summary: the purpose of this study is to determine the relative performance of a new toric soft contact lens against a toric and a spherical contact lens currently available in market, specifically with regards to the fit and visual acuity as well as the comfort, vision and satisfaction while in the practitioner's office. approximately 2 hours duration.

non-dispensing, single-masked (subject-masked), randomised, controlled study.

Eligibility criteria:
inclusion criteria: 1. be at least 18 and less than or equal to 39 years of age and have a need for vision correction in both eyes (monovision or uniocular fitting is not allowed). 2. be of asian descent (japanese, chinese, korean, polynesian or other asian ancestry) and have asian eye anatomy 3. have successfully worn toric or spherical soft (hydrogel or silicone hydrogel) contact lenses for at least 4-weeks prior to enrollment in the study. 4. be able and willing to adhere to the instructions set forth in the protocol. 5. agree to wear their contact lenses in both eyes on a daily wear schedule for at least 8 hours per day every day during the study. 6. have a distance spherical component between -1.00 d and -5.50 d with cylinder in the range of 0.75 d to 2.25 d and cylinder axis within 10 ° of the vertical and within 20 ° of the horizontal in both eyes 7. have a best corrected manifest refraction visual acuity of at least 20/25 or better in each eye. 8. be in good general health, based on his/her knowledge. 9. read, be given an explanation of, indicate understanding of, and sign the statement of informed consent. exclusion criteria: 1. the subject is a rigid gas permeable (rgp) or daily disposable soft lens wearer. 2. the presence of clinically significant (grade 3 or 4) anterior segment abnormalities; inflammations such as iritis; or any infection of the eye, lids, or associated structures. 3. the presence of ocular or systemic disease or need for medication which might interfere with contact lens wear or which would cause the lenses to be removed more than twice a day. (i.e., sjögren's syndrome, type ii diabetes, etc). 4. slit lamp findings that would contraindicate contact lens wear such as: * pathological dry eye or associated findings * pterygium or corneal scars within the visual axis * neovascularization \>1mm in from the limbus * history of giant papillary conjunctivitis (gpc) worse than grade 2 * anterior uveitis or iritis (past or present) * seborrhoeic eczema, seborrhoeic conjunctivitis 5. a history of recurrent erosions, corneal infiltrates, corneal ulcer or fungal infections. 6. a known history of corneal hypoesthesia (reduced corneal sensitivity.) 7. aphakia, keratoconus or a highly irregular cornea. 8. current pregnancy or lactation (to the best of the subject's knowledge). 9. active participation in another clinical study at any time during this study.

Keywords: astigmatism visual acuity fit comfort satisfaction contact lens