Kornimate/medical-research-clean huggingface dataset:
low-vision rehabilitation program for low-vision patients and care givers

Conditions: Low Vision, One Eye, Unspecified Eye; Low Vision Blindness; Low Vision Aids

Summary: to evaluate health related quality of life (hrqol) of low-vision patients and their care givers undergoing low-vision rehabilitation program (lvrp).

to conduct a pilot single-center, single blind longitudinal randomized controlled trial to evaluate health related quality of life (hrqol) of low-vision patients and their care givers undergoing low-vision rehabilitation program (lvrp). lvrp includes functional vision assessments (low-vision refraction), prescription of a variety of visual aids including microscopes, magnifiers, telescopes, absorptive filters and electronic spectacle eyewear, large print books, and automatic self-transcending meditation plus essential skills for daily living and mobility training offered by canadian national institute for the blind (cnib) including demonstration of visual aids as well as training on proper use of visual aids.

Eligibility criteria:
inclusion criteria: * at least 50 years of age * has low-vision, * deemed competent such as no language issues or communication barriers, no self-reported or physician diagnosed mental health disorder besides having depressive and anxiety symptoms, * have sufficient hearing to be able to follow verbal instructions and able to sit without physical discomfort for 30 minutes * willing and able to attend 4 initial astm training sessions and at least 75% of weekly, bi-weekly and monthly follow up sessions, * willing to dedicate 20 minutes twice per day to astm practice at their own home. exclusion criteria: * actively suicidal as per self-report (scoring 2 or more on item 9 of the patient health questionnaire (phq-9) or on assessment by the physician, * currently participating in other similar studies * currently practicing any type of formal meditation regularly

Keywords: low-vision health related quality of life visual aids randomized controlled trial
adverse reactions following covid-19 vaccination among ecuadorian healthcare workers

Conditions: Adverse Drug Event

Summary: limited large-scale studies have been conducted to investigate the adverse effects of covid-19 vaccine in latin america, particularly among the healthcare worker (hcw) population in ecuador. the objective of this study was to assess a cohort of ecuadorian healthcare workers for adverse reactions following vaccination with the pfizer-biontech vaccine.

the covid-19 pandemic bears a burden on medical care and economies worldwide, however immunization at the population level provides a way for to reduce future morbidity and mortality. vaccine hesitancy and reluctance in getting the covid-19 vaccine and apprehensions about them have been present along the course of vaccination programs and mass immunizations across the world. factors such as the quick, large-scale production of vaccines, lack of information, and uncertainty about adverse reactions in the public's eye as well about myths spreading through media channels have given rise to suspicion and fear in the latin american population. limited large-scale studies have been conducted to investigate the adverse effects of covid-19 vaccine in latin america, particularly among the healthcare worker (hcw) population in ecuador. the objective of this study was to assess a cohort of ecuadorian healthcare workers for adverse reactions following vaccination with the pfizer-biontech vaccine.

Eligibility criteria:
inclusion criteria: * ecuadorian nationality * active practice in the medical field * received the pfizer-biontech covid-19 vaccine exclusion criteria: * patients who voluntarily refused to participate.

Keywords: adverse reactions covid-19 healthcare workers latin america vaccination
medium term health coaching and life-long monitoring in cardiovascular disease in norrbotten

Conditions: Diabetes; Heart Disease; Quality of Life

Summary: the purpose of this study is to evaluate whether the introduction of large-scale personalized and technology supported telemonitoring and health coaching interventions produces benefits in terms of health related quality of life, health status and empowerment of patients with a cardiovascular disease. in addition, the trials evaluate the economical and organizational impact of the new services and examine their acceptability by patients and health professionals.


Eligibility criteria:
inclusion criteria: * diagnosis of arterial hypertension ischemic heart disease, * atrial fibrillation or other arrhythmia, * congestive heart failure (study heart disease) * hba1c \> 53mmol/mol (study diabetes) * age \> 18 years * capability of filling in questionnaires in the own language * capability to use the devices provided * being cognitively able to participate

Keywords: promotion health
language localization using repetitive transcranial magnetic stimulation (rtms) in patients with epilepsy

Conditions: Epilepsy, Temporal Lobe

Summary: repetitive transcranial magnetic stimulation (rtms) may be able to provide a moderately detailed localization of language functions in the brain. we propose to test the ability of rtms to locate the substrate of visual naming to a limited area of the temporal lobe in patients with temporal lobe epilepsy before and after surgical resections. the study is expected to yield information on the organization of language in the temporal lobes and how unilateral temporal lobe lesions and lobectomy cause relocation of language mechanisms in the lesioned and in the other hemisphere. it will also be a preliminary step in the development of a clinically useful procedure for locating critical language areas in potential surgical candidates.

repetitive transcranial magnetic stimulation (rtms) may be able to provide a moderately detailed localization of language functions in the brain. we propose to test the ability of rtms to locate the substrate of visual naming to a limited area of the temporal lobe in patients with temporal lobe epilepsy before and after surgical resections. the study is expected to yield information on the organization of language in the temporal lobes and how unilateral temporal lobe lesions and lobectomy cause relocation of language mechanisms in the lesioned and in the other hemisphere. it will also be a preliminary step in the development of a clinically useful procedure for locating critical language areas in potential surgical candidates.

Eligibility criteria:
patients will be drawn from among those referred to the ninds epilepsy research branch. no patients with evidence for a progressive neurological disorder. no subjects with metal hardware in the cranial cavity, cardiac pacemakers, indwelling medication pumps, cochlear implants, intracardiac lines, significant intracranial masses or evidence of increased intracranial pressure. women must not be pregnant.

Keywords: brain mapping cognition noninvasive temporal lobe visual naming
brief intervention to create smoke-free homes policies in low-income households: north carolina effectiveness trial

Conditions: Chronic Disease

Summary: the burden of tobacco use falls disproportionately on low-income populations, through high rates of primary smoking and exposure to secondhand smoke. the remarkable progress in creating smoke-free environments in the u.s. over the past two decades has left smoker's homes as one of the primary sources of exposure to secondhand smoke for both children and nonsmoking adults. intervention research that identifies effective and practical strategies for reaching the minority of households that still allow smoking in the home has considerable potential to reduce smoke exposure, but suitable channels to reach low-income families are limited. the proposed research will systematically test an intervention designed to create smoke-free homes in low income households among 2-1-1 callers. during this randomized control trial, researchers will disseminate and evaluate a brief smoke-free homes intervention through the established infrastructure of a north carolina 2-1-1 call center. 2-1-1 is a nationally designated 3-digit telephone exchange, similar to 9-1-1 for emergencies or 4-1-1 for directory assistance, that links callers to community-based health and social services. the main hypothesis to be tested is that a higher proportion of households in the intervention group will establish and maintain a smoke-free home than in the measures-only control group.


Eligibility criteria:
inclusion criteria: * must be 18 years of age or older. * must speak and understand english. * must smoke and live with at least one other non-smoking person or be a non-smoker who lives with a smoker(s). * must not have a total smoking ban in their home. exclusion criteria: * all participants who are not in immediate crisis will be invited to participate in the study.

Keywords: secondhand smoke exposure smoke-free homes smoke-free home bans
efficacy of smoking cessation intervention for head and neck cancer patients

Conditions: Smoking; Head and Neck Neoplasms

Summary: the purpose of this study is to determine whether a brief smoking ent-resident-based intervention increased smoking cessation in patients with head and neck cancer attending a lebanese university hospital, as compared with usual care.

the primary objective of the study is to evaluate the effectiveness of a brief smoking physician-based intervention on smoking-cessation rates in head and neck cancer adult patients. the secondary objective is to assess predictors of long-term smoking cessation in such patients. after an initial assessment of demographic, clinical and smoking characteristics, the patients are randomised (based on a computer randomisation program) in 2 groups: * group 1 will receive the usual care in lebanon, which consists of a brief advice to quit (10 seconds) * group 2 will receive a brief (10-15 minutes) standardised smoking cessation counseling session peri-operatively (immediately before or after surgery), by an ent residents, based on the 5 "a"'s motivational interviewing model: * ask (screen for tobacco use) * advise (provide a personalised and strong quit message) * assess (evaluate the smoker's willingness and readiness to quit) * assist (provide cessation counseling, pharmacotherapy, self-help guides) * arrange (for followup to prevent relapse, and evaluate cessation progress) a motivational gadget will be distributed to group 2 patients. they will also be offered nicotine replacement therapy (nicotine transdermal patches) for a total of 8 weeks. this will be followed by a telephone boost session after 6 weeks. the follow-up at 3, 6 and 12 months will be done, for the 2 groups, by a person not implicated in either the randomisation or the intervention (single-blind), in person or, if impossible, by telephone.

Eligibility criteria:
inclusion criteria: * head and neck cancer * patients hospitalised from biopsy or surgery * current smokers = smokers in the past 3 months * reachable by phone exclusion criteria: * nonsmokers in the past 3 months * current drug dependance * pregnant women * psychiatric conditions * patients under current smoking cessation intervention

Keywords: smoking cessation intervention head and neck neoplasms cognitive therapy
study of the therapeutic use of language in patients with metastatic colorectal cancer

Conditions: Colorectal Cancer

Summary: the purpose of this study is to determine if the degree of agreement between patients and their physicians regarding the "story" of the illness correlates with improved patient symptom control and quality of life. another goal of the study is to examine the actual language used by patients and physicians in a specific clinical situation.

the purpose of this study is to investigate the co-created therapeutic narrative in scheduled office visits between adult patients with metastatic colorectal carcinoma and their medical oncologists in a community practice setting. the study will focus on the negotiation of the illness narrative and the semiotic (primarily linguistic) tools employed. the study will involve patients from a large community cancer center from northeastern pennsylvania (this center sees about 3,000 new patients each year). about 85% of patients with cancer in the united states are treated in this type of setting (national cancer institute, 2007), and so many results from this population are applicable to most cancer patients in the united states. the location of this study makes it very different from the majority of medical anthropological studies that are usually performed in urban academic medical centers or in sites outside of the united states or western europe. although community cancer centers are the location of most of the treatment of patients with cancer in the united states, there are few to no studies published studying this patient population.

Eligibility criteria:
inclusion criteria: * patients and physicians at hematology and oncology associates of ne pennsylvania * patients must have metastatic (stage iv) colorectal carcinoma * patients must be on treatment for their disease * patients must be scheduled for re-staging ct scans * patients must be older than 18 years old exclusion criteria: * patients with a diagnosis other than metastatic colorectal carcinoma * patients not receiving active treatment or not having re-staging ct scans * patients younger than 18 years old

Keywords: personal communication doctor patient relations narrative medicine
improved diagnostics in food allergy study

Conditions: Food Allergy

Summary: the investigators will conduct low-dose intranasal allergen challenges on children and young people with an indeterminate diagnosis of food allergy to cow's milk or peanut. blood samples will also be taken, for conventional blood allergy diagnostics (allergy-specific immunoglobulin e) and mast cell activation test (mat). the data will be used to determine the diagnostic accuracy of two complementary, novel approaches to diagnose food allergy, in a representative clinical cohort.


Eligibility criteria:
inclusion criteria: * ige-sensitisation to peanut, (hen's) egg or cow's milk, with indeterminate clinical (allergy) status, defined as ige-sensitisation below 95% positive predictive value (ppv) for diagnosis for either allergen-specific ige or spt, using published cut-offs or clinician suspicion of tolerance (on basis of clinical history) despite ige sensitisation \>95% ppv cut-offs. * written informed consent from parent/guardian, with assent from children aged 6 years and above wherever possible. participants aged over 16 years will need to provide their own informed consent. exclusion criteria: * acute illness or current unstable asthma, defined as: 1. febrile ≥38.0oc in last 72 hours 2. acute wheeze in last 72 hours requiring treatment 3. recent admission to hospital in preceding 2 weeks for acute asthma * current medication 1. asthma reliever medication required in preceding 72 hours 2. recent administration of a medicine containing antihistamine within the last 3 days 3. current oral steroid for asthma exacerbation or course completed within last 2 weeks * unwilling or unable to fulfil study requirements
nepafenac once daily for macular edema - study 1

Conditions: Non-Proliferative Diabetic Retinopathy; Cataract

Summary: the purpose of this study is to demonstrate superiority of nepafenac ophthalmic suspension, 0.3% dosed once daily relative to nepafenac vehicle based upon clinical outcomes among diabetic subjects following cataract surgery.


Eligibility criteria:
inclusion criteria: * planned cataract extraction by phacoemulsification with implantation of a posterior chamber intraocular lens; * history of type 1 or 2 diabetes and non-proliferative diabetic retinopathy (npdr) (mild, moderate, or severe) in the study eye; * best corrected visual acuity (bcva) of 73 letters or worse in the study eye with expectation of improvement after surgery; * understand and sign an informed consent document; * other protocol-defined inclusion criteria may apply. exclusion criteria: * pre-existing macular edema in the study eye; * history in the study eye of retinal detachment, wet age-related macular degeneration, chronic or recurrent inflammatory eye disease, or prior procedures; * planned cataract surgery in the fellow eye after randomization and prior to the day 90 postoperative study visit or through study exit; * planned multiple procedures for the study eye during the cataract/intraocular lens implantation surgery; * use of exclusionary medications, including nonsteroidal anti-inflammatory drugs (nsaids) and steroids, as specified in protocol. * participation in any other clinical study within 30 days of the screening visit; * females of childbearing potential who are breast feeding, have a positive urine pregnancy test at screening, are not willing to undergo a urine pregnancy test upon entering or exiting the study, intend to become pregnant during the study, or do not agree to use adequate birth control methods for the duration of the study; * other protocol-defined exclusion criteria may apply.

Keywords: diabetes type i diabetes type ii non-proliferative diabetic retinopathy macular edema cataract
lower-limb drainage mapping in pelvic lymphadenectomy for gynaecological cancer

Conditions: Gynaecological Malignant Tumours With Indication of Pelvic Lymphadenectomy

Summary: the purpose of this study is to evaluate the feasibility of an isotopic technique to identify, and to map the lower-limb drainage nodes during pelvic lymphadenectomy for gynaecological cancers. the diagnostic value of our mapping method will be assessed, and we will determine the incidence of lymhedema.

pelvic lymphadenectomy is associated with a significant risk of lower-limb lymphedema. in this study, we evaluate the feasibility of identifying the lower-limb drainage nodes (lldns) during pelvic lymphadenectomy for gynaecological cancers using an isotopic detection technique with a preoperative radiopharmaceutical injection into both feet secondary objectives are to map lower-limb drainage, to assess the diagnostic value of our mapping technique, and to determine the incidence of lymphedema. lldn mapping may allow the preservation of lldns, thereby decreasing the risk of lower-limb lymphedema and improving quality of life.

Eligibility criteria:
inclusion criteria: * female patients 18 years of age or older with indication of pelvic lymphadenectomy for gynaecological malignancy: * high risk endometrial cancer (stage ib type i grade 3, stage i type ii, stage\> ib) or with metastatic sentinel lymph node, * early cervical cancer, or with metastatic sentinel lymph node, * ovarian cancer. * must provide her signed and informed consent * beneficiary of a health insurance * having received a medical examination exclusion criteria: * contraindication to pelvic lymphadenectomy * presence of lymphedema of the lower limbs * contraindication to radiomarkers (allergy or hypersensitivity to any component of the biomarker) * patient with dementia or altered mental status * pregnant or breast feeding patients * participation in any other clinical trial that could interfere with the study results

Keywords: gynaecological malignancy pelvic lymphadenectomy lymphedema sentinel node reverse mapping
intravitreal bevacizumab (avastin) for pseudophakic macular edema (pme)

Conditions: Cystoid Macular Edema

Summary: to report safety and efficacy of intravitreal injection of bevacizumab in patients with cystoid macular edema secondary to cataract surgery.


Eligibility criteria:
inclusion criteria: * pseudophakic eyes with macular edema exclusion criteria: * other retinopathies
hypnoanalgesia in surgical and endovenous treatment of varicosis

Conditions: Varicose Veins

Summary: endoveinous treatment of saphenous varicoses and phlebectomia of tributary veins are commonly performed under local anesthesia. hypnoanalgesia might reduce perinterventional pain. this study has the aim to test the effectiveness of hypnoanalgesia, performed by a specialised nurse, for peri-and post-procedual pain reduction.


Eligibility criteria:
inclusion criteria: * patients treated under local anesthesia by laser or radiofrequency or phlebectomies for their varicose veins * age of 18 and over exclusion criteria: * na
digital treatment for migraines - a feasibility study

Conditions: Migraine With Aura; Migraine Without Aura

Summary: an individualised internet-based treatment from a biopsychosocial perspective for patients with migraines in primary care has been developed within the vastra gotaland region in 2019. the treatment program is called learning to live with migraines, and goes by the acronym "i am" (internet approach to migraine). in a pilot study, the treatment programme and its feasibility in primary care will be evaluated. it is hoped that the intervention "i am" can educate patients about their illness and help the patient manage migraine attacks so that the likelihood of difficulty and frequency of migraine attacks does not increase, as well as provide an increased function and quality of life.

purpose the overall purpose of the study is to evaluate in a pilot study the practical feasibility of a future randomized study to evaluate personalized digital biopsychosocial treatment method, "i am"- learning to live with migraines in primary care. issues will a large or small percentage of individuals who are asked to participate in the study accept participation? will the random advantage to the different groups make potential participants hesitant? will measuring the effect be practicable? what investigative instruments are appropriate in this situation? is a new investigative instrument to be built? are the interventions reasonable to apply given the resources we can expect to have in a larger study? will a large or small proportion of patients discontinue participation in the study for various reasons? how common are unforeseen problems (which may justify the exclusion of a patient or the negative/harmful effects of the intervention)? what change in endpoints is seen in the different groups?

Eligibility criteria:
inclusion criteria: * women and men * age18 to 65 * diagnosis migraine with (g43.0) or without aura (g43.1) * 3-15 migraine days a month * access to computer/tablet or smartphone with bankid and internet connection exclusion criteria: * ongoing malignant disease * other migraine diseases * moderate to severe psychiatric problems such as depression or anxiety disorder * neuropsychiatric conditions * psychosis disorders * addiction * personality disorders * people who cannot read, speak or understand the swedish language * ongoing psychological/psychotherapeutic treatment
coaguchek xs in antiphospholipid antibody syndrome (apl) patients

Conditions: Antiphospholipid Antibody Syndrome

Summary: the purpose of this study is to see if the coaguchek xs is accurate in measuring international normalized ratio (inr) in patients with antiphospholipid antibody syndrome (apl) receiving warfarin therapy.

antiphospholipid antibody syndrome (apl) is an autoimmune disease that increases ones risk for blood clots. therefore, these patients receive anticoagulation therapy with warfarin. point of care devices such as the coaguchek xs are often used to monitor international normalized ratio (inr) in patients on warfarin. however, the antibodies present in patients with apl may lead to false inr results when using the coaguchek xs. this study will compare the accuracy of the coaguchek xs in measuring inr in patients with apl by measuring inr by the coaguchek xs and a standard lab as a reference point. patients on warfarin for indications other than apl will be measured by both methods as well to serve as a control group.

Eligibility criteria:
inclusion criteria: * 18-65 years of age * anticoagulated with warfarin for at least 1 month * diagnosis of antiphospholipid antibody syndrome for intervention arm exclusion criteria: * any type of mental disability that would hinder their ability to give informed consent * any terminal illness or any other condition that could interfere with study completion, that person will be excluded.

Keywords: anticoagulation international normalized ratio warfarin