Kornimate/medical-research-clean huggingface dataset:
the treatment challenges and limitation in high-voltage pediatric electrical burn at rural area

Conditions: Burns; Electrical Burn; Burn Degree Second; Burn Scar

Summary: a case of high-voltage pediatric electrical burn involving a fully conscious 13-year old boy who was admitted to the emergency room after being electrocuted by high-voltage power cable, with superficial partial thickness burn over right arm, trunk, and left leg (26% of total body surface area) with cardiac abnormality e.g. tachycardia and non-specific st depression. treatments were based on australian new zealand burns association algorithm with several modifications, i.e. administering lower concentration of oxygen with nasal cannula instead of non-rebreathing mask and intravenous ketorolac and metamizole as analgesic instead of morphine due to limitation in infrastructure and knowledge. the patient underwent surgical debridement and strict observation with no signs of abnormality found during hospital stay. wound dressing consisted of silver sulfadiazine, sofra-tulle® and dry sterile gauze were used until epithelialization. after the wound healed, the patient resumed wearing elastic bandage and moisturizer on the wound area. the patient was observed daily through 7 days of hospitalization and followed-up for 1 year, achieving normal physiologic function of the affected area but unsatisfactory esthetic result. this case report showed that there is still a lack of burn prevention programs in the rural area, resulted in inadequate first aid application for electrical burn. there is a need for acknowledging and maximizing the implementation of available standardized guidelines e.g. australian new zealand burns association by giving homogenized training to personnel as well as providing feasible equipment, and then followed by strict monitoring for the patient. the focus of the burn program should also include burn rehabilitation, psychosocial needs and any complaints needing expert opinion in an outpatient setting in addition to adequate burn management for life saving and good wound healing.


Eligibility criteria:
inclusion criteria: * patient with acute electrical burn wound exclusion criteria: * patient does not want to participate
the impact of online educator mircoskill training and parent microskill training on student sexual-health related outcomes

Conditions: HIV/AIDS Prevention; STI Prevention; Pregnancy Prevention

Summary: the goal of this clinical trial is to evaluate the impact of skilltalk among educators, parents, and students. the main question\[s\] it aims to answer are: * what is the impact of skilltalk on student sexual-health related outcomes? * what is the impact of skilltalk on educator microskills? educator participants will use an online microskills training platform for one week. parent participants will be asked to use a parent-specific online microskills training platform for one week. youth participants will not be asked to do anything outside of "business as usual." researchers will compare the treatment groups to the control groups to measure the impact of skilltalk.


Eligibility criteria:
inclusion criteria for educators: * have fewer than three years teaching * teach youth in a class with at least 8 students * be able to obtain supervisor's or administration permission before beginning study * agree to be in compliance with district/school regulations about teaching sexual health and participating in a research study * agree to administer the assent/consent forms and student surveys.\\ inclusion criteria for students: * being in class of teacher who has agreed to participate * parental consent * assent to participate inclusion criteria for parents: * be the parent/guardian of a youth who has assented to participate * consent to their youth's participation * consent to view skilltalk parent site * need to speak english or spanish * access to internet
contribution of the ent (ear, nose, and throat) surgeon's clinical evaluation to the contouring of target volumes and organs eligible for radiotherapy in head and neck cancers

Conditions: Radiotherapy, Conformal (IMRT); Head and Neck Cancer; Otolaryngology; Surgeons; Radiation Oncologists

Summary: radiotherapy (rt), surgery and chemotherapy (ct) are treatments for head and neck cancers, used alone or in combination. conformal rt with intensity modulation (imrt) is currently the reference technique. imrt requires a precise definition of the target volumes to be treated and the anatomical structures to be protected from irradiation. most studies of head and neck cancers published in the literature demonstrate the variability in the contouring of the target volumes between radiotherapists. this may have an impact on dosimetry. to date, no studies have evaluated the impact of the ent surgeon's evaluation in volumes contouring. the aim of this study is to compare the volumes determined by the radiotherapists alone and those determined jointly by the radiotherapists and the ent surgeon.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years; * cancer of the upper aerodigestive tract (oral cavity, oropharynx, larynx, hypopharynx, rhinopharynx, salivary glands, facial sinuses, orbital cavity, ear); * cancer confirmed by histopathological analysis; * therapeutic protocol including radiotherapy. exclusion criteria: * any history of radiotherapy of the head and neck * synchronous head and neck cancer.
autoset for her quality of life clinical trial

Conditions: Obstructive Sleep Apnea

Summary: obstructive sleep apnea (osa) has detrimental effects on the health and quality of life of suffers. recent literature has shown that females may be particularly susceptible to adverse the quality of life effects, and that female obstructive sleep apnea manifests differently than male obstructive sleep apnea. a new autosetting positive airway pressure (pap) device has been designed specifically to treat female osa. in this cohort study, female patients who are newly diagnosed with osa will be asked to complete various questionnaires relating to their quality of life. patients will then use the autoset for her for three months. at the completion of the three months the questionnaires will be repeated. before treatment and after treatment quality of life will be compared to determine if treating female specific osa in these patients improves quality of life.


Eligibility criteria:
inclusion criteria: * females aged ≥ 18 years * diagnostic pg/ psg showing at least moderate osa (ahi ≥ 15) * indication for pap * participants willing and able to give written informed consent * ability to tolerate pap therapy exclusion criteria: * participants currently using cpap or who have previous experience with cpap * participants currently using supplemental oxygen * participants who are pregnant or planning to become pregnant in the next 3 months
using media to reduce anxiety for cardiac computed tomography

Conditions: Anxiety

Summary: coming for a cardiac test can be a daunting experience. despite providing written information sheets for patients, experience in the scanner demonstrates that many patients are ill-prepared when they attend for cardiac computed tomography (ct). heart rate control is essential for high image quality, as this prolongs cardiac diastole (during which imaging occurs) and results in less motion blur, but this may be challenging to achieve in the context of an anxious patient. in such situations, additional radiation exposure is required to optimise the chances of diagnostic images. thus, poor patient selection and preparation has been shown to increase the radiation burden to the patient, as well as to increase the rate of non-diagnostic scans, leading to patients needing additional, alternative testing. this can be distressing for patients and increases downstream costs for the hospital. poor patient awareness is also known to increase the anxiety of attending for a test. improved patient information and understanding has been shown to improve outcomes in a wide variety of hospital settings. evidence from cardiac catheterisation angiography suggests that the use of alternative information formats can reduce patient anxiety and improve patient satisfaction, as well as improving their understanding of the technical requirements of a test. the latter may contribute to improved preparation - for example, patients who do not understand the requirements for cardiac ct, particularly the need for a slow heart rate, will often consume caffeine, stop their heart-slowing drugs, or even run or cycle to their appointment. we have agreed a collaboration with plymouth university to create patient information videos for ct. these will utilise the expertise of media students (their department also runs a commercial arm, due to the quality of their output), in conjunction with the clinical requirements and patient participation groups, to create an accessible, engaging and informative film. we wish to evaluate the impact of this method of conveying information to patients on how well they are prepared to undergo testing. if this concept is successful, it may be of use to patients undergoing a huge range of tests or treatments across specialities. we therefore need to demonstrate the efficacy (or otherwise) of such an intervention.


Eligibility criteria:
inclusion criteria: * all adult patients over 18 years attending for ct coronary angiography during the trial period will be eligible for inclusion exclusion criteria: * unable to provide valid, informed, written consent for any reason * attending for non-coronary cardiac ct * hospital inpatients * patients who have previously undergone cardiac ct

Keywords: cardiac computed tomography image quality
impact of pollution on allergic rhinitis and sleep quality: the pollar study

Conditions: Sleep Apnea; Allergic Rhinitis; Allergic Asthma; Pollution Exposure; Pollution Related Respiratory Disorder

Summary: it has been demonstrated that allergic rhinitis (ar) reduces sleep quality by some components such as nasal obstruction. pollution and allergen exposure worsening ar, sleep quality is deteriorated. sleep is associated to physical and mental health, alterations in sleep could explain the link between ar and work productivity diminution, impairment in daily activities or emotional problems. however, interactions between air pollution, sleep and allergic diseases are insufficiently understood. the main objective of this study is to determine the impact of pollution and pollens on sleep parameters.

over 150 million people have allergic rhinitis (ar) in europe and around 30% have uncontrolled ar during allergen exposure. it has been demonstrated that ar reduces sleep quality by some components such as nasal obstruction. pollution and allergen exposure worsening ar, sleep quality is deteriorated. sleep is associated to physical and mental health, alterations in sleep could explain the link between ar and work productivity diminution, impairment in daily activities or emotional problems. however, interactions between air pollution, sleep and allergic diseases are insufficiently understood. moreover, the prevalence of osa in patients with ar is higher than in subjects without ar. nasal obstruction could explain the increased risk of osa. this prospective, open study will compare sleep quality in 2 different groups: ar patients and patients without ar during the pollen season and outside the pollen season.the main objective is to determine the impact of pollution and pollens on sleep parameters for subjects with ar

Eligibility criteria:
inclusion criteria: * 18-65 years * be able to use an application on a personal smartphone * patient non treated for osa * be legally able to give consent * person affiliated to social security exclusion criteria: - being unable to understand, follow objectives and methods due to cognition or language problems subjects listed in articles l1121-5 à l1121-8: pregnant women, feeding and parturient; subject under administrative or judicial control, persons who are protected under the act.
expanded access use of tucatinib for her2+ metastatic breast cancer


Summary: physicians interested in requesting a single patient ind should contact seattle genetics' medical information (medinfo@seagen.com).


Eligibility criteria:
inclusion criteria: - exclusion criteria: -

Keywords: tucatinib breast cancer arry-380 ont-380 her2 positive breast carcinoma her2 positive locally advanced breast cancer her-2 positive breast cancer her-2 positive locally advanced breast cancer recurrent breast carcinoma stage iv breast cancer metastatic breast cancer breast carcinoma metastatic malignant neoplasm in the brain brain metastases in breast cancer breast neoplasms neoplasms by site neoplasms breast diseases
safety and efficacy of optive in contact lens wearers with dry eyes

Conditions: Dry Eye

Summary: the purpose of this study is to determine if optive®eye drops are safe for people who wear contact lenses and have dry eyes. the second goal of the study is to determine if using optive®eye drops can improve my dry eye scores on a standard dry eye test (called the osdi).


Eligibility criteria:
inclusion criteria: * men and women 18 and over * self-reported use of daily-wear soft contact lenses that have been a proper fit for at least one month prior to the screening visit. * complaint of dry eyes * osdi score \> 23 exclusion criteria: * use of rgp or pmma contact lenses * poorly fitting contact lenses * concurrent ocular conditions or pathology that could affect contact lens fit or patient's ability to complete study * concurrent use of topical medications other than study medications * use of systemic medications with ocular drying sequelae: * antihistamines * decongestants * antispasmotics antidepressants change in contact lens care solutions within the prior 30 days
knowledge, attitude, and practice of pediatric dentists toward obstructive sleep apnea among children

Conditions: Obstructive Sleep Apnea

Summary: the main objective of this study is to assess the knowledge, attitude, and practice of egyptian pediatric dentists toward obstructive sleep apnea among children.

data will be collected using a self-administrated questionnaire developed based on a previous study. the questionnaire was delivered to pediatric dentists, including both dental faculty and practitioners specializing in pediatric dentistry through e-mail and administered in the english language using the google forms platform. the questionnaire began with an invitation message, followed by a consent agreement for participation. it was divided into four sections: demographic information, knowledge about obstructive sleep apnea, attitude toward obstructive sleep apnea, and practice related to obstructive sleep apnea. the demographic section collected information on respondents' age, gender, practice sector (primary health center or private clinic), and years of experience. the knowledge section comprised questions based on the definition of obstructive sleep apnea, followed by 17 knowledge statements to assess the extent of dentists' knowledge about obstructive sleep apnea. these statements covered topics such as prevalence, percentage of affected individuals, symptoms, diagnosis, risk factors, treatment, and the role of dentists in managing obstructive sleep apnea. response options included "true," "false," and "do not know." correct answers were awarded 1 point, whereas incorrect answers received no points. the inclusion of the "do not know" option aimed to minimize guessing and was scored as an incorrect response. the attitude section consisted of seven questions focusing on the role of pediatric dentists in diagnosing and treating obstructive sleep apnea in children, screening for obstructive sleep apnea based on snoring history, considering obstructive sleep apnea screening as a mandatory part of clinical examination, and the need to include obstructive sleep apnea information in the undergraduate curriculum. the response scale for the attitude section included "yes" (1 point awarded, indicating a positive attitude) or "no" or "do not know" (no points awarded, indicating a negative attitude). the practice section encompassed five questions, exploring whether pediatric dentists had fabricated oral appliances for managing obstructive sleep apnea, their approach to history taking including questions to rule out the presence of obstructive sleep apnea, and their participation in continuing education courses related to the topic.

Eligibility criteria:
inclusion criteria: * pediatric dentists exclusion criteria: * undergraduate student

Keywords: knowledge attitude practice pediatric dentist obstructive sleep apnea
intrapleural fibrinolytic therapy to enhance chemical pleurodesis enhance chemical pleurodesis

Conditions: Pleural Effusion

Summary: prospective randomized double-blind controlled trial of intrapleural fibrinolytic therapy to enhance chemical pleurodesis versus standard of care talc therapy in patients with recurrent pleural effusion.

this protocol describes a prospective, randomized, double-blind controlled trial comparing tsp alone to the combination of tsp with cathflo activase for achieving optimal results with pleurodesis for recurrent pleural effusion. patients who sign informed consent will be randomly assigned to receive either tsp alone (talc, 5 gm in 50 ml ns) with placebo (50 ml ns) or tsp with cathflo activase (4 mg in 50 ml ns) through the chest pleural catheter. follow-up lasts for three months. the primary outcome is achievement of a "radiographically satisfactory pleurodesis" (rsp) by day three post-procedure, defined as chest tube drainage of less than 100cc over 24 hours and a chest x-ray showing similar or less pleural space opacification than on the day tsp was performed (baseline, day 0). secondary outcomes include the proportion of patients who achieve rsp, time needed to achieve rsp, duration of chest tube drainage, length of hospital stay after initiation of tsp, proportion of patients requiring repeat tsp, change in serum hemoglobin during therapy, objective assessments of pain and dyspnea, and potential complications. this study will recruit 136 patients, with an interim analyses for efficacy after 50 patients, and aims to help develop the future standard for management of patients requiring pleurodesis for their symptomatic pleural effusion.

Eligibility criteria:
inclusion criteria: 1. age \> 18 years 2. symptomatic pleural effusion requiring intervention 3. expected survival \> 3 months 4. written informed consent to trial participation exclusion criteria: 1. females who are pregnant or lactating 2. inability to obtain consent from the patient or patient's designated representative. 3. inability of the patient to comply with the protocol. 4. previously documented adverse reaction to talc or cathflo activase. 5. oral or intravenous steroid therapy
rivet pvs therapy in group 2 ph-hfpef canada

Conditions: Heart Failure; Pulmonary Hypertension

Summary: this clinical investigation is a prospective, multicenter, non-randomized, open-label, early feasibility study to evaluate the safety, performance, and initial clinical efficacy of the rivet pvs therapy in patients with symptomatic pulmonary hypertension.


Eligibility criteria:
select inclusion criteria: * age ≥ 18 years * prior diagnosis of group 2 ph due to hfpef, with at least one of the following resting hemodynamic criteria confirmed in the past year by right heart catheterization 1. mpap \> 20 mmhg at rest 2. mpap/co slope \> 3 mmhg/l/min with exercise * confirmation of the following hemodynamic criteria during supine exercise: pcwp ≥ 25 mmhg, or pcwp/co slope \> 2 mmhg/l/min * chronic symptomatic heart failure documented by the following: 1. nyha hf class ii with history \> ii, or class iii, or ambulatory class iv 2. ≥ 1 hf hospitalization, or healthcare facility with iv diuretics or intensification of oral diuresis for hf within 12 months, or nt-pro bnp value \> 400 pg/ml in normal sinus rhythm or \> 750 pg/ml in atrial fibrillation in past 6 months * ongoing stable guideline directed medical therapy (gdmt) for hf and medically optimized per treating cardiologist according to current accf/aha guidelines that is expected to be maintained without change for 1 month (excluding diuretic dosage changes for hf optimization within 30 days of the index procedure) * 6mwd ≥ 100 m select exclusion criteria: * any therapeutic intracardiac intervention within the last 30 days * ph group 1, 3, 4 or 5 * mean rap \>16 mmhg by rhc at rest on room air * right ventricular dysfunction, defined as one or more of the following 1. greater than moderate rv dysfunction as assessed by tte and/or mri 2. rv fac \< 35% 3. tapse \< 14 mm via tte 4. rv size severely enlarged compared to lv size as estimated by tte and/or mri * severe tricuspid valve regurgitation * peak systolic pulmonary arterial pressure \> 80 mmhg by rhc at rest while awake * mean pulmonary arterial pressure \> 50 mmhg by rhc at rest while awake * pvr \> 6 wood units at rest while awake on room air * left ventricular ejection fraction \< 50% * severe heart failure, defined as one or more of the following: 1. acc/aha/esc stage d heart failure, non-ambulatory nyha class iv hf 2. if bmi \< 30, cardiac index \< 2.0 l/min/m2 3. if bmi ≥ 30, cardiac index \< 1.8 l/min/m2 4. requires continuous intravenous inotropic infusion 5. requires mechanical circulatory support 6. currently on the cardiac transplant waiting list * chronic renal dysfunction defined as: egfr \< 35 ml/min/1.73 m2 by the ckd-epi equation * chronic pulmonary disease defined as one or more of the following: 1. requires continuous home oxygen therapy 2. recent hospitalization for exacerbation within 12 months prior to screening 3. fev1 \< 50% predicted