Kornimate/medical-research-clean huggingface dataset:
comparison between dexchlorpheniramine and dexchlorpheniramine/pseudoephedrine/guaifenesin in respiratory infections

Conditions: Viral Infections of the Upper Respiratory Tract

Summary: patients with allergic rhinitis frequently present exacerbation of the atopic symptoms during viral infections of the upper respiratory tract. also, allergic rhinitis makes the mucosa more reactive to infectious agents and potentiates mucus production. the combination of dexchlorpheniramine, pseudoephedrine and guaifenesin elicits antihistaminic, decongestant and expectorant effects. the study hypothesizes is that this product is superior to dexchlorpheniramine alone in the relief of allergic symptoms and in promoting mucus elimination in atopic patients with viral infections of the upper respiratory tract.


Eligibility criteria:
inclusion criteria: * patients with allergic rhinitis with symptoms of viral infection of the upper respiratory tract (rhinorrhea, nasal obstruction and productive cough) * compliance of the subject to the treatment protocol * agreement with the terms of the informed consent * patients who did not use forbidden medications exclusion criteria: * history of allergy to any component of the formulations * use of any investigational drug within the last 30 days * patients with bacterial infections of the upper respiratory tract * patients with high blood pressure (\> 140 x 90 mmhg) * patients who are receiving inhaled beta-agonists or other antihistamine, decongestant or expectorant * patients with known pulmonary disease (asthma, copd, neoplasias) * pregnancy * hiv + patients * other conditions considered by the investigator as reasonable for non-eligibility

Keywords: allergic rhinitis viral infections of the upper respiratory tract dexchlorpheniramine pseudoephedrine guaifenesin
mass continous suture with pds versus interrupted suture with thread on major abdominal incision

Conditions: Surgical Wound; Suture, Complication

Summary: a better suture technology will reduce postoperative incision complications. this study is designed to compare mass continous suture with pds and interrupted suture with thread on major abdominal incision.

a better suture technology will reduce postoperative incision complications. the previous retrospective cohort study from the investigator has demonstrated that continuous mass suture with pds led to shorter incision closure time, early wound healing and comparable incisional complications versus interrupted thread suture. as such, the current rct study will include 100 subjects with major abdominal incision. they will be divided into two groups randomly: mass suture gorup, mass continuous suture with pds, control group, interrupted suture with thread. the wound healing time, stitches removal time and incidence of incision complications will be compared between the two groups.

Eligibility criteria:
inclusion criteria: * the patient with major abdominal incision. * the incision is longer than 10 cm * aged between 18 to 65 years old exclusion criteria: * pregnant woman * patient with diabetes * patient with a history of cardiovascular disease, including coronary heart disease and stroke. * severe lung diseases such as copd and asthma * patients undergoing emergent or infectious surgery * patients with surgical site infection * no autonomy, inability or unwillingness to participate in follow-up

Keywords: surgical wound suture, complication
enteral nutrition and abdominal massage

Conditions: Intensive Care Unit Syndrome

Summary: this study will be conducted to determine the effect of abominal massage on feeding intolerance and blood sugar levels in intensive care patients who are continuously feeding enterally and have diabetes.

introduction: many multiple and challenging problems are encountered in patients followed in intensive care. the most important of these symptoms is nutritional problems. one of the most commonly used methods in the treatment of nutritional problems is enteral nutrition. in addition to its beneficial results, gastrointestinal problems such as abdominal distension, constipation, diarrhea, nausea and vomiting may be encountered in enteral fed individuals in intensive care units. although different methods are used in the management of complications that may develop in enterally fed patients, abdominal massage, which is one of the non-invasive nursing practices, has been shown to reduce feeding intolerance and balance blood glucose levels. purpose: this study will be conducted to determine the effect of abominal massage applied to intensive care patients who are continuously fed enterally and have diabetes, on feeding intolerance and blood sugar levels. method: this study will be conducted using a randomized controlled research design. the research sample will consist of 64 patients hospitalized in the intensive care units of a state hospital in merzifon and who meet the inclusion criteria. research data will be collected using the clinical status information form, patient parameters monitoring form, and bristol stool scale. patients in the massage group will receive an abdominal massage twice a day for 5 days, between 10.00 in the morning and 22.00 in the evening. for the control group, routine treatment and care practices in the hospital will continue without any additional intervention for these 5 days, and the same data will be evaluated at the same time. conclusion: it is thought that abdominal massage applied to intensive care patients with diabetes who are continuously fed enterally will reduce feeding intolerance and affect blood sugar levels.

Eligibility criteria:
inclusion criteria: the age of 18 years and over diagnosed with diabetes mellitus having just started continuous enteral feeding via nasogastric tube glasgow coma scale \>3 patients who do not have a wound in the abdominal area patients without current diarrhea, constipation, vomiting, abdominal distension patients who gave their consent to participate in the research exclusion criteria: patients who had started enteral feeding before starting the study patients who received radiotherapy to the abdominal area abdominal surgery within the last three months patients with ileus patients using medications that affect gastrointestinal motility

Keywords: massage
effect of magnesium supplementation on elevated systolic blood pressure

Conditions: Blood Pressure

Summary: the purpose of this study is to assess whether 480 mg/day magnesium glycinate supplementation for 12 weeks lowers blood pressure.

this clinical trial will test whether a magnesium glycinate supplement (480 mg/day) taken for 12 weeks lowers blood pressure in 120 adults aged 30-74 who have a systolic blood pressure of 130-154 mmhg. eligibility to participate in the trial will be determined by a 2-stage screening process. interested participants will complete a pre-screening form online. if eligibility criteria are met, the potential participants will be scheduled for an in-person screening clinic visit. at the visit, eligible participants will be reminded about the study details and potential risks and will be given the opportunity to sign the informed consent. consented participants will be assigned by chance (like a coin toss) to daily magnesium or to placebo. participants will take 4 study capsules per day (2 capsules in the morning and 2 capsules in the evening) for 12 weeks. assessments at the screening visit include seated blood pressure; pulse; weight, height, waist and hip circumference measurements; fasting blood and urine collection; and health and diet questionnaires. participants will return for a clinic visit at 12 weeks to assess these measures.

Eligibility criteria:
inclusion criteria: * self-report of systolic blood pressure 125-159 mmhg * measured seated systolic blood pressure 130-159 mmhg at screening visit * body mass index less than 40 kg/m2 * total magnesium intake from supplements of no more than 100 mg/day * willing to maintain current diet and supplement use patterns during the 12-week intervention period exclusion criteria: * measured seated diastolic blood pressure 100 mmhg or greater at screening visit * antacid or laxative use 4 times/week or more within the past 3 months * history of cardiovascular disease (myocardial infarction, stroke, revascularization \[coronary artery bypass graft or percutaneous transluminal coronary angioplasty\], or angina pectoris) * history of invasive cancer diagnosed within the last 5 years (non-melanoma skin cancer permitted) * history of type 1 or 2 diabetes * history of renal disease * history of kidney failure * history of dialysis * history of pancreatitis * history of inflammatory bowel disease * history of hypermagnesemia * women who are pregnant, nursing, or intend to become pregnant during the period of treatment * plan to relocate out of boston area within the next year * unwillingness and/or inability to swallow 4 pills per day * inability to provide written informed consent
healthy mood internet recruitment study

Conditions: Recruitment

Summary: this study is pilot testing a self-help automated website (similar to a self-help book) designed to help individuals to learn methods to manage their mood. the methods are cognitive-behavioral skills found effective in the treatment of depression when provided by live therapists. the purpose of the study is to determine the number of individuals who will visit the site, use the site, and respond to online surveys reporting their mood levels while using the site, and at 1, 3, and 6 months after starting to use the site. the investigators want to eventually examine whether learning these methods online would help prevent depression.

self-help automated website in spanish and english consisting of an 8-lesson course on mood management based on cognitive behavioral methods. accessible via the web. follow-up assessments conducted at 1, 3, and 6 months.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * valid email address * fluent in english exclusion criteria: * less than 18 years of age * no valid email address * not fluent in english

Keywords: mood management self-help depression prevention cognitive behavioral
sensory stimulation to enhance hand function post stroke

Conditions: Stroke

Summary: the objective of this pilot project is to assess the impact of the novel sensory stimulation technique the investigators have developed in enhancing outcomes of hand therapy as well as the central nervous system responsiveness in chronic stroke survivors.

stroke survivors suffer from persistent hand impairment that diminishes their functional abilities and independence, despite multiple courses of rehabilitation. sensory stimulation can prime central excitability to increase therapy outcome. the investigators developed a new sensory stimulation technique for the hand, using imperceptible vibration applied to the wrist skin. wearable devices with a vibrating function are low cost and can be easily adopted for rehabilitation purposes to impact a wide range of patients with sensorimotor impairment. despite the potential for clinical benefits and easy adoption for high impact, knowledge about the long-term efficacy of this new sensory stimulation technique and its underlying mechanism is limited. the objective of this pilot project is to assess the impact of the novel sensory stimulation technique the investigators have developed in enhancing outcomes of 2-week hand therapy as well as the central nervous system responsiveness in chronic stroke survivors. this impact will be assessed in a double-blind stratified randomized controlled trial. the hypothesis is that (a) improvement in hand function will be greater for the experimental group receiving the wrist subthreshold vibrotactile stimulation during therapy compared with the control group who will wear the device with no vibration (placebo). (b) improvement in hand function is associated with neurophysiologic measures of central nervous system responsiveness. clinical and neurophysiologic evaluations will be performed before, immediately after, and 2 weeks after a 2 week standardized hand therapy program with the subthreshold vibrotactile stimulation to the wrist vs. sham. the investigators preliminary studies demonstrated an acute effect of the remote subthreshold vibrotactile stimulation on immediately improved clinical sensory and motor function of the hand as well as cortical excitability in healthy young adults and chronic stroke survivors in single-session studies. the expected outcome is the demonstration that the subthreshold vibrotactile stimulation at the wrist enhances hand function, not only immediately (preliminary studies) but also as a complement to therapy in chronic stroke survivors. this project will also provide preliminary insights regarding plasticity occurring with hand therapy augmented by the subthreshold vibrotactile stimulation. this research will have a positive impact by leading to a portable sensorimotor orthosis worn at the wrist to improve hand function for patients with sensorimotor deficits.

Eligibility criteria:
inclusion criteria: * mild to moderate impairment in upper extremity function exclusion criteria: * cognitive dysfunction * stroke\<3 months * treatment with botulinum toxin in the affected arm within 3 months of start of study

Keywords: hand function
itt-5 mechanisms of spermatogenesis in man

Conditions: Gonadotropin Deficiency

Summary: the purpose of this investigational drug study is to determine how much male hormone, testosterone, is needed to maintain sperm production in the testis.

this is a nine-month research study examining the effects on androgen treatment on sperm production in healthy men. there are three phase to the study, a 2-month screening phase, 4-month treatment and 3-month follow-up. in this study, the investigators aim to define a quantitative relationship between intra-testicular testosterone (it-t) and spermatogenesis in man. hormone levels will be measured in a small amount of testicular fluid at the beginning and end of treatment and sperm concentration will be measured.

Eligibility criteria:
inclusion criteria: * males age 18-55 * in general good health based on normal screening evaluation * normal serum testosterone, lutenizing hormone (lh) and follicle stimulating hormone (fsh) * prostate specific antigen (psa) \< 3.0 * agrees not to donate blood or participate in another research study during the study * informed consent * must be willing to use a reliable form of contraception during the study exclusion criteria: * participation in a long-term male contraceptive study within the past three months * history of testosterone or anabolic steroid abuse in the past * history of or current skin disorder that will interfere with testosterone gel * poor general health or significantly abnormal screening blood results * history of or current testicular or prostate disease * history of a bleeding disorder or need for anticoagulation * history of untreated sleep apnea and/or major psychiatric problems * bmi \> 32 * history of or current liver disease * chronic pain syndrome * current use of terfenidine, astemizole, cisapride, budesonide, felodipine, fluticasone, lovastatin, midazolam, sildenafil, or vardenafil * use of glucocorticoids or underlying adrenal insufficiency * active drug or alcohol abuse within the past year

Keywords: intratesticular androgens testosterone dutasteride gonadotropin suppression male contraception spermatogenesis
respiratory morbidities and outcome in late preterm in neonatal icu

Conditions: Respiratory Morbidities

Summary: aim of the work: to assess the respiratory morbidities \& outcomes in late preterm infants in the neonatal icu of assiut university children's hospital.

in the world, preterm birth rates continue to rise. many reasons account for this increase, such as demographic changes, infertility treatments, increases in maternal age, more multiple gestations, increasing obesity rates, and maternal comorbid conditions. to evaluate the occurrence and impact of a condition, a precise definition and its related outcomes are necessary. thus, a general classification for selected gestational age categories has been reported. preterm birth refers to all deliveries \< 37-0/7 weeks; this classification includes very preterm (\< 32-0/7 weeks), moderately preterm (32-0/7 to 33-6/7 weeks), and late preterm births (34-0/7 to 36-6/7 weeks). term births refer to deliveries that occur from 37-0/7 to 42-0/7 weeks, and post-term births refer to any delivery occurring after 42-0/7 weeks. neonates born between 34 and 36 weeks of gestation (late preterm or near-term births) comprise 71% of all preterm births in the united states. late preterm neonates have significantly higher rates of morbidity and mortality relative to those born at term (37-42 weeks). in addition to higher risks for serious health complications, the mortality rate for late preterm infants is 3-fold higher than that for term infants (7.7 vs 2.5 per 1000 live births). late preterm delivery (71% of all preterm births) increases the incidence of respiratory pathology as respiratory distress syndrome (rds), transient tachypnea of the newborn (ttn), pneumonia with chest x-ray verification, persistent apnea and bradycardia, pulmonary hypertension, pneumothorax, meconium aspiration, pulmonary hypoplasia,( respiratory failure ) and the need of ventilator support when compared to term delivery. late preterm newborns increase other risks for feeding difficulty, jaundice, hypoglycemia, temperature instability, apnea, and respiratory distress.

Eligibility criteria:
inclusion criteria: * late preterm neonates admitted to the neonatal intensive care unit (nicu) at assiut university children's hospital for one year. exclusion criteria: patients with congenital heart diseases and multiple congenital anomalies.
interest of hi-rte elasticity in obstetric

Conditions: Premature Birth

Summary: in obstetric, the investigators can't predict accurately with current means (bishop score, traditional cervix ultrasonography and fibronectin) the childbirth time and delay. if ultrasonography can determine the length, the cervix opening, it can't define its flexibility. indeed, the conventional cervix ultrasonography can't inform us about the consistency of the uterine cervix. the elastography (elasticity imagery) is an innovating technology. it is a new technology currently used as part of breast cancer estimate. this diagnosis mean use the ultrasonography to measure the tissues answer under pressure. its contribution in obstetric must be estimated to improve patients minimum fare. the main target of the investigators study is to estimate the interest of the measure of cervix elasticity degree by elastography in prediction of premature birth within a population of pregnant women


Eligibility criteria:
inclusion criteria: * unique(only) or multiple pregnancy about is the term presenting an intra utérine pregnancy in the 1st quarter · * signed lit(enlightened) consent · * patient of more than 18 years old exclusion criteria: * suspicion of pregnancy extra utérine, hémodynamique unstable, important métrorragies, maternal diabetes, arterial high blood pressure * impossibility to receive the consent lit(enlightened) by the patient · patient old under age 18

Keywords: estimate the interest of the measure of cervix elasticity degree by elastography in prediction of premature birth within a population of pregnant women
pharmacokinetic study of capecitabine in elderly cancer patient (≥ 75 years)

Conditions: Breast Cancer; Colorectal Cancer

Summary: the aim of the study is to determine blood concentration evolution of capecitabine and its active metabolites, in elderly patient 75 years and more.

blood samples will be taken before 1rst course of chemotherapy of capécitabine for colorectal or breast metastatic cancer. pharmacokinetic will be realizes at several times (h0,5, h1, h1,5, h2, h4, h6, h8) and repeated at d14 of the 2d cycle

Eligibility criteria:
inclusion criteria: * elderly patients 75 years old or more * life expectancy of greater then or equal to 6 months * histologically proven metastatic breast or colorectal cancer, requiring a chemotherapy by capecitabine according to the habitual schema * metastatic situation whatever treatment line * previous hormonotherapy for breast cancer, prior chemotherapy (without capecitabine) in adjuvant and/or metastatic indication (colorectal or breast cancer), or radiotherapy (colorectal or breast cancer) are allowed * one or more measurable target lesion (recist criteria) * adl\>4 (geriatric scales) * gsd\<12 (geriatric scales) * laboratory values : * creatinine clearance (crcl) \>=30 ml/min according to cockcroft formula * adequate bone marrow function (neutrophils count \> 1.5 x 10\^9/l, platelets \> 100 x 10\^9/l, hemoglobin \[hb\] \> 10g/dl) * adequate hepatic function: total bilirubin \< 1,5 x upper normal limit, aspartate aminotransferase (asat) and alanine aminotransferase (alat) \< 2,5x upper normal limits (in case of liver metastases \< 5 x upper normal limits) * alcalin phosphatases \<=2,5x uln (\<=5 x uln if liver metastases present). * subjects must be willing to be followed during the course of treatment/observation and follow-up. * signed written informed consent before first course of chemotheray exclusion criteria: * age \< 75 years * known brain metastases * concomitant oncologic treatment ongoing * history of severe or unscheduled reaction to fluoropyrimidine treatment * prior unanticipated severe reaction to capecitabine or metabolites and to fluoropyrimidine therapy * patient with leucopenia * sorivudine or chemical analogues treatment like brivudine * physiological, familial, sociological, or geographical conditions that do not permit compliance with the protocol. * concomitant severe affections wich lead life expectancy inferior to 3 monthes * uncontrolled or symptomatic angina, arrhythmias, or congestive heart failure, coronarian spasmes * no possible oral administration * known dpd deficiency * treatment with experimental therapy ongoing or within four weeks before inclusion. * other cancers within the last five years, with the exception of adequately treated cone-biopsied in situ carcinoma of the uterin cervix or basal or squamous cell carcinoma of the skin

Keywords: capecitabine pharmacocinetics breast metastatic cancer colorectal metastatic cancer elderly patients
the effect of morphine on prasugrel absorption in stemi patients

Conditions: Cardiovascular Disease

Summary: heart attacks are a major cause of death in this country. when patients have a heart attack, they are treated with anti-clotting drugs, one of which is a drug called prasugrel. it is important that prasugrel starts to work as quickly as possible following a heart attack. as many patients who have a heart attack experience excruciating pain, they are often given morphine (a strong painkiller) by the ambulance crew. we think that morphine may affect how prasugrel is absorbed from the stomach and may delay how quickly it starts to work. we intend to study the effect of morphine on the absorption of prasugrel.


Eligibility criteria:
inclusion criteria: * \>18 years of age and willing and able to provide informed consent * admission to hospital with a stemi \>12 months prior to recruitment * previous prasugrel and morphine use with no adverse effect exclusion criteria: * active respiratory disorder, resting oxygen saturation \< 95% or decompensated congestive cardiac failure * current use of anti-platelet or anti-coagulant drugs apart from aspirin 75 mg daily, or receipt of any dose of clopidogrel, prasugrel or ticagrelor in the last 2 weeks * current use of opiate analgesia