Kornimate/medical-research-clean huggingface dataset:
neuromuscular responses to acute beetroot ingestion in women older adults

Conditions: Dietary Supplement; Placebo

Summary: beetroot juice supplementation has shown the capacity for provoking different physiological effects (e.g. vasodilation and muscle contraction increments). however, the effects of beetroot juice ingestion on neuromuscular performance in women older adults are barely studied. in this randomized placebo-controlled study, we investigated the effects of beetroot acute supplementation in improving neuromuscular performance in women older adults

beetroot juice supplementation has shown the capacity for provoking different physiological effects that could affect human performance (e.g. vasodilation and muscle contraction increments). although this dietary supplement has been commonly used for improving sports performance in recreational or professional athletes, the scientific literature in older adults is scarce. thus, in our knowledge, no previous studies have analyzed the side effects associated to ingestion in this population group. in this randomized placebo-controlled study, we investigated the effects of beetroot acute supplementation in improving neuromuscular performance and side effects associated with ingestion in women older adults.

Eligibility criteria:
inclusion criteria: * women \>65 or \<85 years of age. * in good health, as determined by the investigator's review of history. exclusion criteria: (based in previous studies on this topic (doi: 10.1093/gerona/glaa311). men and women \ 85 years of age unable to provide informed consent current smokers significant orthopedic limitations or other contraindications to strenuous exercise those taking proton pump inhibitors, antacids, xanthine oxidase inhibitors, or on hormone replacement therapy those taking anti-coagulants or on anti-platelet therapy history of neuromuscular disease (e.g., cervical spondylotic radiculomyelpathy, lumbar spondylosis, amyotrophic lateral sclerosis, guillain-barré syndrome, and acquired demyelinating polyneuropathies) cardiovascular disease (e.g., \> stage i hypertension, heart failure, myocardial infarction/ischemia significant myocardial or pericardial diseases (e.g. amyloidosis, constriction), moderate or severe valvular disease, renal disease, liver disease, or anemia

Keywords: dietary supplements nitrate neuromuscular function
osteoporosis and chronic obstructive pulmonary disease (copd)

Conditions: COPD; Osteoporosis; Osteopenia

Summary: the goals of the trial are: * to determine the prevalence of osteoporosis in subgroups of copd patients. * to look for risk factors of osteoporosis in copd patients. * to create sub-groups for prospective research concerning the effects of bisphosphonates on osteoporosis variables in copd patients.

background: osteoporosis is defined as a systemically skeletal disorder characterized by a low bone mass and deterioration of the micro-architecture of the bone and is therefore associated with a higher risk of fractures. large epidemiological studies to determine the incidence and prevalence of osteoporosis in copd patients in different stages of their disease are not available. the etiology of osteoporosis in copd patients is complex and depends on multiple factors. goals of the trial: * to determine the prevalence of osteoporosis in subgroups of copd patients. * to look for risk factors of osteoporosis in copd patients. * to create sub-groups for prospective research concerning the effects of bisphosphonates on osteoporosis variables in copd patients. study design: patients diagnosed with copd (according to the american thoracic society \[ats\] guidelines and divided in stages according to the global initiative on obstructive lung diseases \[gold\]-classification) who visit the out-patient clinic of pulmonology of the catharina hospital eindhoven will be asked to participate in the trial. a database will be created (prospectively) of the (medical) information about these patients, which will be analysed retrospective. to gather information we will use the medical records, a questionnaire, a blood sample, long function testing including a 6-minute walking test and a dexa-scan.

Eligibility criteria:
inclusion criteria: * age \> 18 years * men and women * copd according to the ats-guidelines, divided in severity according to the gold criteria * written consent exclusion criteria: * age \< 18 years * no written consent

Keywords: copd osteoporosis osteopenia glucocorticoids gold bode
pharmacokinetics of wck 2349 in patients with hepatic impairment

Conditions: Hepatic Impairment

Summary: this study is aimed to compare the pharmacokinetics of levonadifloxacin and its sulfate metabolite after a single dose of oral wck 2349 1000 mg in patients with hepatic impairment and healthy volunteers.


Eligibility criteria:
inclusion criteria: * body mass index (bmi): 18.0 - 38.0 (body weight in kg / height in m2), both inclusive. * subjects must fulfill the following criteria: patients with hepatic impairment: * considered clinically stable in the opinion of the investigator * patients with different degrees of impaired hepatic function as assessed by a child-pugh classification score: mild (5-6 points), moderate (7-9 points) and severe (10-15 points) impaired hepatic function. * documented history of cirrhosis diagnosed by liver biopsy, ultrasonography (usg), computed tomography (ct) scan, or magnetic resonance imaging (mri) or healthy volunteers: * have normal hepatic function * participants with a history of self-limited hepatitis a with complete resolution documented at least 6 months prior to entry will be allowed exclusion criteria: * known hypersensitivity to quinolones/fluoroquinolones. * subjects must not fulfill the following criteria: in hepatically impaired patients: * use of prohibited concomitant medication, with the exception of those essential for the management of hepatic impairment and the treatment of concomitant stable medical conditions for the hepatically impaired patients as per the discretion of the investigator. * fluctuating or rapidly deteriorating hepatic function as indicated by recent history or widely varying or worsening of clinical and/or laboratory signs of hepatic impairment as judged by the investigator. * concomitant treatment with interferon or other prohibited medications * active stage 3 and stage 4 encephalopathy or healthy volunteers: * use of any concomitant medication within 7 days from the screening except those deemed safe for the study by the investigator and medical monitor. * history of any clinically significant chronic and/or active hepatic disease including elevations of serum transaminases including aspartate aminotransferase (ast) and alanine aminotransferase (alt) \[except those which are considered non-significant by the investigator; however, these should not exceed 1.5 times the upper limit of normal (uln)\], hepatitis (hepatitis a, b or c), biliary tract disease, or history of any significant gastrointestinal surgery.
group intervention on theory of mind in children with autism spectrum disorder.

Conditions: Autism Spectrum Disorder

Summary: the project involves the participation of 40 children with autism spectrum disorder of both sexes, aged between 6 and 10 years. the subjects will undergo a pre-intervention evaluation phase, which will consist of administering the theory of mind (tom) test present in the neuropsycology second edition (nepsy) battery, part a. the same test will be administered again at the end of the intervention. once the inclusion criteria have been met and following the randomization of the sample, divided into experimental group (eg n=20) and control group (cg n=20), the administration of the search task will proceed. the study involves 12 sessions, one per week, lasting 45 minutes. the eg will view twelve social scenes created through a tablet. in the scenario, the depictions will be presented in color. guided by the narrating voice of qt robot, they will have to choose between two or three alternatives the one that represents the appropriate mental state by selecting it on the tablet. consequently, an audio-visual feedback will be provided, through the robot, to give the subject information about the accuracy of their response. in both groups, a simple instruction will be given to the child, telling them to pay attention to the story that will be narrated and then answer simple questions. in the eg, qt robot will speak, while in the cg it will be the operator. the prompts will be related to the accuracy of the response or they will rather be aimed at encouraging the child to give the correct answer.


Eligibility criteria:
inclusion criteria: * proven diagnosis of autism * qs ≥ 75 assessed by administration of the griffiths scales * passing the emotional recognition test of the nepsy ii battery exclusion criteria: * presence of other medical disorders

Keywords: autism children theory of mind
tips versus portacaval shunt for acute bleeding varices in cirrhosis

Conditions: Bleeding

Summary: in unselected cirrhotic patients with acute portal hypertension-related bleeding to compare the effectiveness in control of bleeding, mortality rate, duration of life, quality of life, and economic costs of two widely used treatment measures: (1) emergency transjugular intrahepatic portal-systemic shunt (tips), and (2) emergency portacaval shunt.


Eligibility criteria:
inclusion criteria: * all patients with ugi bleeding who are shown to have the findings of cirrhosis and esophagogastric varices or portal hypertensive gastropathy and require 2 or more units of blood transfusion will be included. exclusion criteria: * none

Keywords: survival and control of hemorrhage
intra-operative evaluation of a novel fluorescent c-met tracer in penile and tongue

Conditions: Head and Neck Cancer; Penile Cancer

Summary: in this study we evaluate the feasibility of intraoperative visualization of penile and tongue tumours using the fluorescent tracer emi-137.

this is a single-center, non-randomized, prospective interventional pilot study. feasibility of intraoperatively visualizing tumour (margins) in penile and tongue tumours using emi-137 will be investigated. patients, ≥ 18 years of age, with ≥t1 penile or tongue cancer undergoing primary tumour surgery will be included. all patients will receive an intravenous bolus injection of emi-137 prior to surgery. main study parameters/endpoints are: intraoperative visualization of primary penile or tongue tumours using a dedicated clinical fluorescence camera. the in vivo detected fluorescence signal will be correlated to ex vivo measurements and pathological assessment of the ex-cised tissue.

Eligibility criteria:
inclusion criteria: * written informed consent, prior to performing any protocol related procedures. * age ≥ 18 years at time of study entry. * ≥ t1 penile or tongue squamous cell cancer * scheduled for surgical primary tumour resection exclusion criteria: * involvement in the planning and/or conduct of the study. * pregnant woman * abstaining from usage of two forms of barrier contraceptive or actively planning pregnancy within 90 days. * severe kidney insufficiency

Keywords: surgery fluorescent c-met tracer penile tongue
hemorrhagic complications of transvaginal oocyte's retrieval: an update.

Conditions: ART; Infertility

Summary: the goal of this retrospective analysis is to focus on peritoneal bleeding after oocyte retrieval and to further investigate factors related to this specific complication and if hemorrhagic complication rate modifications can be observed.

the main aim is to update our knowledge on oocyte retrieval complication, focusing specifically on hemorrhagic / hemoperitoneum rate. all retrievals will be retrieved in ivf/icsi cycles and fertility preservation both in oncological patients and in patients requesting oocyte storage for deferring motherhood. data collection goes from january 2017 to december 2022.

Eligibility criteria:
inclusion criteria: * patients that underwent a procedure of oocyte transvaginal retrieval for ivf/ intracytoplasmatic sperm injection (icsi) cycles and fertility preservation exclusion criteria: -
comparing pain and swelling after surgical extraction of mandibular third molar in dexamethasone injection and without corticosteroid methods

Conditions: Oral Health; Molar, Third

Summary: in some cases, impacted wisdom teeth should be extracted. surgical extraction of these impacted third molars may provide special complication as pain, swelling, and trismus. in previous studies, some techniques as sutureless flap closure, modified flap designing, antibiotic usage, and injection of corticosteroids were presented. these methods are reducing post operative complications to moderate level. in this study, pain, swelling, trismus, general patients' satisfaction, and associated quality of life after the surgical removal of third mandibular impacted molars will be compared while injection of dexamethasone (8mg) does not need excessive time, effort, and equipments and it will be injected in numbness area into medial pterygoid muscle and pterygomandibular space to current corticosteroid injecting non-corticosteroid methods. to achieve this aim, 75 non pregnant participants have single impacted mandibular third molar in healthy and without pericoronitis manner, after provision of written informed consent will be entered to the study. during the study, unwilling participants to continue the study and those with abnormality of wound healing process will be excluded. the included participants will be assigned into three 25-people groups. the surgeries were done by 3 same instructed experienced oral and maxillofacial residents. after the surgery pain, swelling, trismus, general patients' satisfaction, and associated quality of life were evaluated using interview of questionnaire in 48 hour, 96 hour, and one week period of time. the comparison was done between these three groups.


Eligibility criteria:
inclusion criteria: * non pregnant participants have single impacted mandibular third molar in healthy and without pericoronitis manner * they must have no contra-indication for injection of the corticosteroid and lidocaine with epinephrine * should not medicated by any possibly bias maker drug * type of the impaction, must not provide sever difficulty * the participants should be mentally at healthy level and provide written informed consent to incorporate in the study exclusion criteria: -unwilling participants to continue the study and those with abnormality of wound healing process

Keywords: third molar edema pain trismus
stress and immunity breast cancer project

Conditions: Breast Cancer Stage II; Breast Cancer Stage III

Summary: an investigative study of the effectiveness of the biobehavioral intervention on stage ii/iii breast cancer patients. a total of 231 patients were split between an assessment-only control group and an experimental group receiving the intervention and assessment. the goal of the intervention is to use psychological, behavioral, and biologic methods with the primary goal of reducing cancer recurrence.


Eligibility criteria:
inclusion criteria: * stage ii or iii breast cancer diagnosis prior to adjuvant therapy exclusion criteria: -
myo-inositol and melatonin in pre-menopausal women

Conditions: Pre-menopausal Irregular Cycles and Bleedings

Summary: the purpose of this study is to determine whether myo-inositol and melatonin, or myo-inositol alone, or melatonin alone, are effective in normalizing irregular bleeding and anovulatory cycles in pre-menopausal women.

melatonin has produced a remarkable significant improvement of thyroid function, positive changes of gonadotropins towards reduced levels, and in some women a re-acquisition of normal menstrual cycle. furthermore, an abrogation of menopause-related depression, amelioration of hot-flashes and improvement of quality and duration of sleep has been reported. myo-inositol is involved in several aspects of human reproduction. elevated concentrations of myo-inositol in human follicular fluids appear to play a positive function in follicular maturity and provide a marker of good quality oocytes. nevertheless its positive role in pcos women is a consequence of a defect in the insulin signalling pathway (inositol-containing phosphoglycan mediators) that seems to be primarily implicated in the pathogenesis of insulin resistance

Eligibility criteria:
inclusion criteria: * all pre-menopausal women with irregular cycles and bleedings exclusion criteria: * pre-menopausal women who take hormonal drugs

Keywords: pre-menopause melatonin myo-inositol
systemic chemotherapy plus pd-1 for metastasis icc

Conditions: ICC; Metastatic Cancer

Summary: this study were designed to verify the better method of survival for metastatic icc. since the traditional method for metastatic icc was gemox(recommended from nccn guideline), our previous study found better results from folfirinox over gemox. our current study were conducted for further investigation to verify the better method for metastatic icc.

icc(intrahepatic cholangiocarcinoma) patients with metastasis has a short survival time and poor prognosis after diagnosis. treatment methods was few and far from satisfaction. the treatment recommended from nccn guideline was gemox(systemic chemotheray) and clinical trials. our previous study has demonstrate folfirinox(systemic chemotheray based on oxaliplatin，5-fluorouracil and irinotecan) has a survival and tumor response advantage of gemox. further study was needed to intensive confirmation of the result. we designed this study to demonstrate the hypothesis. metastasis iccs were recruited and screened by our criteria. all patients were treated with folfirinox(systemic chemotheray based on oxaliplatin，5-fluorouracil and irinotecan) plus pd1(sintilimab). the progression free survival and overall survival were our primary and secondary endpoint. our study were designed to verify the better method of survival for metastatic icc.

Eligibility criteria:
inclusion criteria: * the diagnosis of icc * with distant metastasis * patients must have at least one tumor lesion that can be accurately measured according to mrecist criteria. * with no previous treatment * no cirrhosis or cirrhotic status of child-pugh class a only * not amendable to surgical resection ,local ablative therapy and any other cured treatment * the following laboratory parameters: platelet count ≥ 50,000/μl hemoglobin ≥ 8.5 g/dl total bilirubin ≤ 30mmol/ l serum albumin ≥ 32 g/l asl and ast ≤ 6 x upper limit of normal serum creatinine ≤ 1.5 x upper limit of normal inr ≤ 1.5 or pt/aptt within normal limits absolute neutrophil count (anc) \>1,500/mm3 exclusion criteria: * evidence of hepatic decompensation including ascites, gastrointestinal bleeding or hepatic encephalopathy * known history of hiv * history of organ allograft * known or suspected allergy to the investigational agents or any agent given in association with this trial. * cardiac ventricular arrhythmias requiring anti-arrhythmic therapy * evidence of bleeding diathesis. * patients with clinically significant gastrointestinal bleeding within 30 days prior to study entry.

Keywords: icc metastasis
comparison of outcome of treatment of topical 15%tca vs topical 0.05% tretinoin in treatment of acanthosis nigricans

Conditions: Acanthosis Nigricans

Summary: acanthosis nigricans (an) is a dermatosis with aesthetic implications and is characterized by the focal or diffuse development of a velvety, hyperpigmented cutaneous thickening in intertriginous areas. trichloroacetic acid (tca), a superficial chemical exfoliative agent has shown efficacy in treating acanthosis nigricans. data from this would help in establishing it as a treatment of choice thereby lead to reduction in cost and benefit the patient both financially and psychologically.

acanthosis nigricans is common, although exact prevalence depends upon the racial makeup of the population studied. exact pathogenesis is unknown, elevated insulin concentrations result in direct and indirect activation of igf-1 receptors on keratinocytes and fibroblasts, leading to proliferation. this hyperpigmentation, which has poorly defined borders, usually occurs in skin fold areas symmetrically, such as the back of the neck, axilla and groin, and may rarely involve oral mucosa. the lesions may be related to a wide range of benign conditions and may occur as a paraneoplastic manifestation of various potentially fatal malignancies.

Eligibility criteria:
inclusion criteria: * patients who will present with acanthosis nigricans as per operational definition will be included in the study. * either gender. * age 20-50 years. exclusion criteria: pregnancy. * breastfeeding. * patients with history of skin resurfacing by dermabrasion, chemical peels and facial laser within the preceding 9 months. * patients with history of hypersensitivity. * malignant acanthosis nigricans. * drug induced acanthosis nigricans.
molecular pathology research project of glioma

Conditions: Glioma, Malignant

Summary: evaluate the diagnostic value of tert promoter mutation in differ glioma subtypes and expend the application of the diagnostic algorithm to surgical practice

a total of 976 gliomas were enrolled in this study. first, in order to evaluate the diagnostic value of tert promoter mutation in differ glioma subtypes, we conducted a retrospective cohort study included 753 frozen tissue samples of patients with different grades of glioma. according to who cns5, all recommended alteration including idh, 1p/19q, tert, egframp and 7+/10- were profiled using multiple approaches and a permanent diagnosis was obtained for each patient. exploring the feasibility of the molecular pathology model of patients with glioma via retrospective research. compare with the existing molecular pathology system, analyze the combination of idh and tert mutations and the feasibility of stratifying the prognosis of patients with glioma. moreover, to expend the application of the diagnostic algorithm to surgical practice, we developed a fast detection assay that could detect hotspot somatic mutations in idh and tert within 25 minutes and can discriminate tert and idh mutations from wild-type alleles with a minimum variant allele frequency (vaf) of 0.2% and 0.5%, respectively. we further validate the simplified diagnostic algorithm on frozen tissue of 223 patients with glioma in another retrospective cohort and performed this assay to evaluate the accuracy of the rapid assay.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of glioma * glioma patient with long-term follow-up data and intact clinical data exclusion criteria: * glioma patient without informed consent form * glioma patient without long-term follow-up data or intact clinical data

Keywords: molecular pathology
molecular effects of vitamin b3 (niacinamide) in acute kidney injury

Conditions: Acute Kidney Injury

Summary: this is a single center, randomized, single-blind, placebo-controlled study to evaluate the safety and biochemical effects of niacinamide on metabolic parameters of the kidney in patients undergoing cardiac surgery.


Eligibility criteria:
inclusion criteria 1. all patients undergoing cardiac surgery with the use of cardiopulmonary bypass at high risk for acute kidney injury. a cleveland score of 6 or more is used to define patients at high risk for acute kidney injury 2. age ≥ 18 3. signed informed consent exclusion criteria 1. pre-existing acute kidney injury 2. kidney transplantation 3. off-pump heart surgery 4. pregnancy 5. end stage renal disease 6. pregnancy (female subjects of childbearing potential must have a negative serum pregnancy test) 7. subjects with any kind of dependency on the investigator (e.g. any subject who is under direct supervision of the investigator/co-investigators or employed by the investigator/co-investigators) 8 subjects held in an institution by legal or official order (e.g. subjects in jail, prison, juvenile offender facility, or treatment facility including those who are in hospitals, alcohol, and drug treatment facilities under court order, and individuals with psychiatric illnesses who have been committed involuntarily to an institution)