Kornimate/medical-research-clean huggingface dataset:
evaluation of cerebrospinal fluid flow in adolescent idiopathic scoliosis

Conditions: Adolescent Idiopathic Scoliosis

Summary: adolescent idiopathic scoliosis (ais) is the most frequent spinal deformity in adolescence, but its etiology remains unknown. recent publications suggest a link between ciliopathy and ais. more specifically a modification of the cerebro-spinal fluid (csf) flow by ciliary dysfunction could be at the origin of a scoliotic deformity. this study aims to compare the csf flow measured by magnetic resonance imaging (mri) in an ais group and a control group.


Eligibility criteria:
common inclusion criteria for the 2 groups : * female subject aged 12 to \< 18 years old * affiliated to the french social security system * having signed the inform consent form * whose parents have given their consent additional inclusion criteria for the ais group: * subject with right thoracic ais defined by the existence of a 3d spine deformation with a frontal deviation to right dorsal convexity with a cobb angle of at least 20°, and a rotation of at least 20°, as evidenced by the presence of a vertebral gibbosity ≥ 5° at the bunnel scoliometer. if the scoliosis has more than one curvature, the right chest curvature should be the greatest high (highest frontal cobb angle) * subject with x-rays of total spine, face and profile under load, according to the eos technique, dating from less than 3 months. common exclusion criteria for the 2 groups: * instability to submit to the medical follow-up of the study for psychic, social or geographical reasons * at least 6 "cafe au lait" spots with a size ≥ 1.5 cm (may be suggestive of neurofibromatosis) * ligament hyperlaxity confirmed by a beighton score \>4/9 (which may be suggestive of scoliosis secondary) * contraindications of a cerebro-medullary mri: claustrophobia, foreign bodies, and ferrometallic clips of the trunk or cephalic segment, cochlear implants, stimulators and implantable cardiac defibrillators, insulin pump * inequality in length of the lower limbs ≥ 20 mm on clinical examination * subject presenting neurological signs (signs of pyramidal irritation, sensory-motor deficit, clinical signs suggestive of cerebellar pathology ...) * known vestibular pathology * taking psychotropic drugs additional exclusion criterion for the ais group: * subject with secondary scoliosis : neurological, orthopedic, malformative... additional criteria for the control group: * subject with a scoliosis angle ≥ 10° on a photogrammetric screening assessment (optical process, non-irradiating, which allows an morphometric evaluation of the trunk in 3d, thanks to the analysis of the trunk reliefs) * subject whose clinical examination shows a gibbosity measurable (\>5°) with the scoliometer of bunnel

Keywords: cerebrospinal fluid flow mri graviception postural control
pilot study of the safety of a daily ethanol lock for urinary catheters in critically ill children

Conditions: Complication of Urinary Catheter

Summary: hypothesis 1: blood alcohol concentration will be \<25 mg/100ml (equivalent to a blood alcohol concentration of \<0.025%) after a 1 hour urinary catheter ethanol lock. hypothesis 2: daily urinary catheter ethanol locks will not result in increased hematuria or increased urinary white cells.

this study involves a confirmatory/refuting approach to the above stated hypothesis. the investigators will test this hypothesis by addressing the following aims/objectives: specific aim 1: quantify blood alcohol levels after a 1 hour 74% ethanol lock in urinary catheters utilized in the pediatric intensive care unit. specific aim 2: compare cellular components in urinalyses after the introduction of the ethanol locks. potential study subjects will be recruited from the children's healthcare of atlanta - egleston pediatric intensive care unit. children that are anticipated to have an indwelling urinary catheter for \>48 hours will be included. for this pilot study, the investigators will enroll 10 patients. subject ages will range from 6 months to 17 years. children who are on a service other than critical care medicine will have clearance from the primary team prior to approaching for enrollment. the consent process will take place prior to or during the initial 24 hours of urinary catheter placement.

Eligibility criteria:
inclusion criteria: * age: 6 months - 17 years * urinary catheter placed at children's healthcare of atlanta * anticipated urinary catheter need for \> 48 hours * parent or legal guardian (or patient when applicable) consent for enrollment. exclusion criteria: * 18 yo or older. * urosepsis at time of study enrollment * known bladder or genitourinary abnormalities * chronic bladder drainage regimen * urologic surgeries (as part of the current admission) * medical urgency preventing timely administration of the consenting process, or any condition that, in the opinion of the attending physician, would place the patient at undue risk by participating. * anuria or oliguria (\<0.5 cc/kg/hr averaged over the previous 12 hours) * other technical considerations that would prevent the timely acquisition of sufficient samples such as (but not limited to) absence of a study team member. * parent or legal guardian (or patient when applicable) refuses to sign informed consent.

Keywords: ethanol lock alcohol lock urinary catheter safety
attention training technique in treatment of anxiety and depression in coronary heart disease patients

Conditions: Depression, Anxiety; Coronary Artery Disease

Summary: anxiety and depression are associated with work disability, lower participation rate in cardiac rehabilitation and unfavourable life style changes following a coronary heart disease (chd) event. the prevalence of clinically significant symptoms of depression and anxiety in chd patients has been estimated to 30-50%. furthermore, depression and anxiety are associated with a significant increased risk of subsequent major adverse cardiovascular events and mortality in chd patients. psychological interventions for anxiety and depression in chd patients have demonstrated small and uncertain effects of symptoms, and no effect on cardiovascular outcomes. therefore, testing the effectiveness of specific psychological interventions that may affect central mechanisms for cardiovascular outcomes, has been requested. the attention training (att) study is a randomized controlled trial comparing group-attention training to wait-list control in 64 patients who experience significant anxiety and depression after a chd event. it will also be explored whether reduction in psychological symptoms is correlated with changes in biological markers with a potential link to cardiovascular outcomes.


Eligibility criteria:
inclusion criteria: * established coronary heart disease as main somatic disease * \>=8 on either hads-anxiety or depression subscale * age 18 - 65 years * the ability to understand and speak norwegian language, * willingness and ability to give informed consent. exclusion criteria: * current or past neurological illness * traumatic brain injury * current alcohol and/or substance dependency disorders * psychotic disorders * bipolar disorders * developmental disorders * mental retardation * cognitive impairment which precludes informed consent/ability to participate * acute suicidality * life-expectancy less than 12 months * concurrent psychological intervention for emotional distress * antidepressant or anxiolytic medication initiated during previous 8 weeks
a clinical study of tranilast in the treatment of mucinoses

Conditions: Mucinoses

Summary: 56 participants with mucinoses will be selected to receive treatment of tranilast. after a period of time ,the investigators can determine the efficacy of the drug by detecting the the thickness and area of skin before and after treatment.

56 participants with mucinoses will be selected. after the signing of the informed consent ,participants will be collected the initial lesions photos,the thickness and area of skin lesions by ultrasound and magnetic resonance,and chemical examinations including blood routine examination, routine urine test, liver function, renal function. during tranilast (0.1g each time, three times a day,12 months) treatment, participants need regular follow-up (1 per month) including liver and kidney function, blood glucose level monitoring, and every three months to retest lesion thickness and area. with 3 month as a time point, participants were observed for four points. after the experiment, the experimental data will be arranged and the data of the thickness and area change of skin lesions will be statistically processed to determine whether it is meaningful.

Eligibility criteria:
inclusion criteria: 1. clinical and histopathological examination has been proved to be mucinoses; 2. ultrasound and magnetic resonance detection found that the skin was thickened. exclusion criteria: 1. with a liver or kidney disease, or accompanied by a severe infection; 2. poor control of primary disease; 3. with mental disease.

Keywords: mucinoses tranilast
rapamycin therapy for patients with tuberous sclerosis complex and sporadic lam

Conditions: Tuberous Sclerosis; Lymphangioleiomyomatosis

Summary: the purpose of this study was to determine if rapamycin reduced angiomyolipomata volume in patients with tuberous sclerosis complex or lam.

the study design was an open label, phase i/ii trial of sirolimus for one year followed by one year off therapy.patients were seen at baseline,at two weeks to four weeks, and at 2,4,6,9,12,18 and 24 months. angiomyolipomata imaging was performed at all but the two to four week visit. complete pulmonary function tests and six-minute walk were obtained at baseline,6 or 9 month, 12 and 24 month visits, while simple spirometry only was performed at all other visits.

Eligibility criteria:
inclusion criteria: * diagnosed with angiomyolipomas and have either tuberous sclerosis complex or lymphangioleiomyomatosis * between the gaes of 18 and 65 years * competency to voluntarily consent * clinically definite diagnosis of tuberous sclerosis or s-lam * adequate contraception * at least one angiomyolipoma of 1 cm or greater in largest diameter exclusion criteria: * use of continuous supplemental oxygen * concurrent infection * recent surgery * ongoing or planned pregnancy * lactation * use of an investigational drug within the last 30 days of study entrance

Keywords: tsc and lam tuberous sclerosis complex and sporadic lam
st250 as a therapeutic option for head & neck reconstruction

Conditions: Tonsillitis

Summary: to assess the use of suprathel 250 for mucosal reconstruction in the head \& neck region. the membrane will be applied after tonsillectomy procedures and compared to bare wounds' healing

after tonsillectomy procedures, the wound is usually left bare to heal. this causes severe pain postoperatively and postoperative hemorrhage. suprathel 250 is a synthetic biodegradable pla membrane which is proven as a skin membrane in burn wounds with excellent result. we therefore hypothesize that the use opf suprathel 250 after tonsillectomy procedures will allow for faster , less painful healing of the wound bed which allows for a better quality of life for the patients.

Eligibility criteria:
inclusion criteria: * recurrent episodes of tonsillar infection exclusion criteria: * children * pregnant/ breastfeeding women * patients undergoing chemo / radiotherapy

Keywords: pla membrane biodegradable membrane synthetic tonsillectomy
dna methylation in malar melasma and its change by sunscreen, retinoic acid and niacinamide.

Conditions: Melasma

Summary: background: malar melasma has a chronic and recurrent character that may be related with epigenetic changes.

objective: recognize the dna methylation status of the malar melasma and perilesional skin, and its change after treatment with 50 spf sunscreen (s), 4% niacinamide (n), or 0.025% retinoic acid (ra). methods: fifty-six lesion of 28 female patients without treatment were clinically evaluated, as also the expression of dna methyl transferases 1 and 3 by real time-pcr (polymerase chain reaction amplification), immunohistochemistry and immunofluorescence. it was initially quantified and after 8 weeks of treatment with s, ra and n. results: relative expression of dna methyl transferases were significantly elevated compared with unaffected skin in all subjects indicating hypermethylation of dna. hypermethylation decreased by s (7 vs 3 times relative expression, p\<0.05), ra (7 vs 2 times relative expression p\<0.05), and n (7 vs 1 relative expression p\<0.01) correlated with clinical improvement, this was also supported by immunohistochemistry and immunofluorescence. conclusions: the investigators found hypermethylation of dna in melasma lesions. environmental factors such as sun radiation may induce dna hypermethylation triggering hyperpigmentation trough the activation of pathways regulated by epigenetic modifications. thus, decreasing methylation by sunscreen protection and the genetic transcription modification through n and ra, may allow their clinical improvement regardless its depigmenting effect.

Eligibility criteria:
inclusion criteria: clinical diagnosis of malar melasma by a specialist. no previous treatment at the beginning of the study. exclusion criteria: use of medications associated with the development of melasma. pregnant or lactating patients. presence of concomitant diseases associated with the development of melasma. or other facial hyperpigmentations (thyroid, liver). have received treatment in the last 2 months. regular use of sunscreen.

Keywords: epigenetics, malar melasma,
qigong intervention program for abused chinese women

Conditions: Abused Women

Summary: the purpose of this study is to evaluate the effect of a qigong intervention program on telomerase activity in chinese women with a history of intimate partner violence.

qigong is a mind-body exercise rooted in the paradigm of traditional chinese medicine, aiming to achieve a harmonious flow of energy (qi) in the body through gentle movements and is thus considered as a holistic health practice towards promoting physical and mental well-being and improving longevity. it was suggested that qigong exercise, as a stress management strategy, could be effective in improving psychological symptoms, as well as enhancing cellular telomerase activity by reducing oxidative stress level and regulating immune response. the study is to evaluate the effects of a qigong intervention on telomerase activity and pro-inflammation cytokines, perceived stress, perceived coping, and depressive symptoms in chinese women with a history of intimate partner violence. the study design is a randomized, wait-list controlled design with intervention and wait-list control groups. a total of 240 chinese abused women will be recruited. the qigong intervention program consists of: (i) a 2-hr group qigong training twice a week for 6 weeks; (ii) weekly group follow-up of a 1-hour group qigong exercise for 4 months; and (iii) self-practice of qigong exercise for 30 minutes each day throughout the intervention period lasting 5.5 months. it is hypothesized that the participants in the intervention group will have higher levels of telomerase activity and perceived coping, and lower levels of pro-inflammation cytokines, perceived stress, and depressive symptoms, on completion of a qigong intervention program, compared to abused chinese women in the wait-list control group.

Eligibility criteria:
inclusion criteria: * 18 years of age or older, * willing to undertake the qigong intervention program, * available for all testing points, * receptive to random allocation, and * assessed to be abused by an intimate partner in the preceding year or longer, based on the chinese abuse assessment screen. exclusion criteria: * had participated in qigong training or other mind body intervention within the previous 6 months, or * have serious medical conditions that might limit their participation in qigong exercise (based on our previous experience, such conditions include cancer, severe obesity, narcolepsy, major depressive disorder, schizophrenia), or * have psychiatric disorders, or * use medication or other psychological intervention for stress, or * are abused by someone who is not their intimate partner.

Keywords: qigong telomerase perceived stress rct chinese abused women intervention depression
high potency cannabis: acute and protracted effects

Conditions: Abuse Cannabis; Pain; Pharmacokinetics

Summary: the purpose of this research is to assess the effects of smoked cananbis when cannabis is smoked during periods of cannabis use as usual and after a brief period of abstinence.

this outpatient study will assess the acute pharmacodynamic effects of smoked cannabis with \~50 mg and \~100 mg thc compared to placebo (\~0 mg thc) and whether a brief period of abstinence alters these effects. metabolism (pharmacokinetics) of thc will be examined to associate behavioral and physiological effects to plasma concentrations of thc and metabolites.

Eligibility criteria:
inclusion criteria: * • male or non-pregnant and non-lactating females aged 21-55 years * report cannabis smoking near daily * not currently seeking treatment for their cannabis use * have a body mass index from 18.5 - 34kg/m2. * able to perform all study procedures * must be using a contraceptive (hormonal or barrier methods) exclusion criteria: * meeting dsm-v criteria for any substance use disorder other than cannabis, nicotine, caffeine * do not have positive urine toxicology for cannabis use during screening * evidence of severe psychiatric illness (e.g. mood or anxiety disorder with functional impairment or suicide risk, schizophrenia) judged by the study physician (and pi) to put the participant at greater risk of experiencing adverse events due to completion of study procedures, interfere with their ability to participate in the study, or their capacity to provide informed consent. * report using other illicit drugs in the prior 4 weeks * current predominant licit use of medical cannabis, prescription analgesics, or any medications that may affect study outcomes * current pain * pregnancy * currently enrolled in another research protocol * not using a contraceptive method (hormonal or barrier methods) * insensitivity to the cold water stimulus of the cold pressor test * any disorders that might make cannabis administration hazardous as determined by evaluation physician after review of all medical assessments along with medical history. * not able to speak and read english

Keywords: thc cannabis
comparison of deferasirox and desferoxamine in patients of β-thalassemia major with iron overload

Conditions: Pateints of β-thalassemia Major With Iron Overload

Summary: this study was planned to compare deferasirox and desferrioxamine in terms of mean serum ferritin levels in patients of β-thalassemia major having iron overload. choosing an effective iron chelator is crucial to increasing iron chelation therapy compliance. not much local data exists in pakistan comparing the effectiveness of deferasirox (dfx) and desferrioxamine (dfo), so, this study would be helpful in providing baseline data and formulating new protocols for iron chelation therapy, in which dfx may be a useful oral alternative to parenteral dfo.


Eligibility criteria:
inclusion criteria: * diagnosis of β-thalassemia major (as per medical record or confirmed by hemoglobin electrophoresis) * iron overload (serum ferritin level above 1000 µg/l) exclusion criteria: * patients with other transfusion-dependent anemias * thalassemia major with cardiomyopathy or arrhythmia. * chronic renal failure * chronic liver disease (alt \>200 iu) * hhypersensitivity to deferasirox or desferrioxamine * patients already on combined chelation therapy
impact of the preemi package on neonatal mortality

Conditions: Preterm Birth; Preterm Labor; Neonatal Death

Summary: the purpose of this quality improvement initiative is to reduce severe morbidity and mortality among premature infants through proven and cost-effective clinical management during the antenatal, intrapartum, and postpartum periods. in order to reduce neonatal mortality and morbidity due to preterm birth complications, health facilities must be able to identify and manage women in preterm labor, accurately administer medications, and provide high-quality postnatal care.

the purpose of this quality improvement initiative is to reduce severe morbidity and mortality among premature infants through proven and cost-effective clinical management during the antenatal, intrapartum, and postpartum periods. in order to reduce neonatal mortality and morbidity due to preterm birth complications, health facilities must be able to identify and manage women in preterm labor, accurately administer medications, and provide high-quality postnatal care. the study will provide evidence of implementing a package of clinical interventions coupled with quality improvement and monitoring strategy aimed at reducing neonatal mortality in 3 resource-limited health facilities, leveraging on an existing strengthened birth registry to provide neonatal outcomes up to 28 days after delivery. additionally, using a multifaceted approach through an interdisciplinary team, the investigators will identify the social and cultural barriers that contribute to home-based deliveries. these findings will be helpful to the ministry of health in shaping future policies regarding the scale-up of newborn care clinical protocols as part of government's efforts to reducing neonatal mortality in zambia.

Eligibility criteria:
inclusion criteria: * pregnant women who seek antenatal care services and plan to deliver in the selected health facilities * women who reside within the larger catchment area of the selected 3 health facilities exclusion criteria: * women who reside outside the larger catchment area of the health facilities * women who have not sought antenatal care services in the 3 health facilities and have come to only deliver there

Keywords: facility delivery neonatal mortality preterm delivery preterm birth perinatal mortality
extended release naltrexone for opioid-dependent youth

Conditions: Drug Dependence

Summary: the purpose of this study is to compare 6-month treatment outcomes for 15-21 year old opioid-dependent youth receiving extended release naltrexone (xr-ntx) v. treatment as usual (tau).

this proposed study is a 6-month, two-group randomized clinical trial of xr-ntx v. tau for 340 opioid-dependent youth ages 15-21. the study will be conducted at mountain manor treatment center, a community drug treatment program in baltimore. tau will consist of buprenorphine treatment of opioid withdrawal followed by counseling with or without continued buprenorphine.

Eligibility criteria:
inclusion criteria: * meets diagnostic and statistical manual-iv criteria for opioid dependence, physiologic subtype; * within 3 days of admission to mmtc; * age between 15 and 21, inclusive; * able and willing to provide informed consent to be randomly assigned to xr- ntx or tau; and for participants under 18 years of age, parental or guardian consent and participant assent. exclusion criteria: * liver function test levels (alanine transaminase, aspartate transaminase) four times greater than normal; * unstable medical or psychiatric illness (e.g., schizophrenia) that might make participation hazardous; * history of serious suicide attempt in the past 6 months; * history of allergic reaction to naloxone, and/or naltrexone; * current chronic pain condition for which opioids are deemed necessary for ongoing care; * blood coagulation disorder (e.g., hemophilia); * body mass index \> 40; * if female, pregnant, lactating, unwilling or unable (due to parental objection) to use fda-approved contraceptive methods; * meeting dsm-iv criteria for benzodiazepine dependence

Keywords: opioid dependence