Kornimate/medical-research-clean huggingface dataset:
safety and efficacy of terbogrel in patients with primary pulmonary hypertension

Conditions: Hypertension, Pulmonary

Summary: this study sought to determine whether terbogrel was an effective treatment for primary pulmonary hypertension (pph) by comparing its efficacy and safety to that of placebo.


Eligibility criteria:
inclusion criteria: * primary pulmonary hypertension and new york health association (nyha) chronic heart failure (chf) functional class ii-iii * ability to walk \>= 50 meters on the 6 minute walk test * resting mean pulmonary artery pressure \> 25 mmhg * mean right atrial pressure \<= 20 mmhg * pulmonary capillary wedge pressure \<= 15 mmhg * cardiac index \> 2.5 l/min2 * svo2 sat. \> 63% * male of female at least 18 years old * signed written informed consent exclusion criteria: * secondary pulmonary hypertension due to lung or systemic diseases * pregnant of nursing women, or women of childbearing potential who are not using adequate methods of birth control * concurrent systematic use of aspirin, aspirin like drugs, or non-steroidal anti-inflammatory drugs (nsaids) * surgery of bleeding from gastrointestinal, genitourinary tract, cerebrum or retina within past 6 weeks * history of bleeding diathesis or a platelet count less than 70,000/mm3 * exercise limited by factors other than fatigue or exertional dyspnea, such as arthritis, claudication, angina, chronic obstructive pulmonary disease, or bronchial asthma * myocardial infarction, stroke, or transient ischemic attack within the preceding six months * systolic blood pressure \ 180 mmhg, or diastolic blood pressure \> 110 mmhg * known drug or alcohol dependency within one year of entry into the study * known hypersensitivity to any component of the study formulation, epoprostenol, nitric oxide, or adenosine * psychiatric or other illness or condition which, in the opinion of the principal investigator, may interfere with study participation, compliance, or other elements of the protocol * participation in an evaluation of an investigational drug within the past 30 days * portal hypertension or cirrhosis of the liver * congenital heart disease e.g., atrial septal defect; patent foramen ovale does not exclude patient from the study * appetite suppressants such as fenfluramine, dexfenfluramine, and inhibitors of serotonin uptake known to be associated with primary pulmonary hypertension, received within 3 months of entry into the study * hiv positive * vasodilators. patients will not receive ca-channel blockers during the study unless the medication was started prior to the study and the patient has been on a stable dose for at least one month prior to entry
the effect of pilates exercise and whatsapp text-based support program on premenstrual syndrome (pms) symptoms

Conditions: Premenstrual Syndrome; Physical Exercise; Women's Health

Summary: the aim of this study is to evaluate the effect of pilates exercise and whatsapp text message-based support program on pms symptoms experienced by university female students.

in this study, it will be answered whether the pilates exercise and the support program based on whatsapp text messages have an effect on the pms symptoms experienced by university female students. demographic information of the participants will be collected with the personal information form. the personal information form is a form prepared by the researchers with the support of the literature, consisting of 21 questions aiming to obtain information about the socio-demographic characteristics, menstrual characteristics, and lifestyle behaviors of the students. pms symptoms will be evaluated with the premenstrual syndrome scale. first of all, the premenstrual syndrome scale will be applied by trying to reach all 380 female students studying at the school. afterward, 68 students with pms who meet the inclusion criteria will be divided into 34 intervention and 34 control groups by simple randomization. in order to prevent interaction between the intervention and control group students in the randomization, the places where the students stay (home, dormitory rooms) will be taken into account. a support program including pilates exercise and whatsapp text messages will be applied to the initiative group for 8 weeks. no attempt will be made on the control group.

Eligibility criteria:
inclusion criteria: * having regular menstrual cycles (intervals of 21-35 days, lasting 3-10 days), * body mass index of 18.5-24.9 kg/m. to be between * absence of chronic disease, * absence of a hormonal disease such as polycystic ovary syndrome, * using smart mobile phone * not using oral contraceptives or antidepressants. exclusion criteria: * - having a chronic or physical illness that prevents pilates.

Keywords: premenstrual syndrome pilates exercises text message women's health
comparison of peg solutions with and without electrolytes in the treatment of constipation

Conditions: Constipation

Summary: the aim of the study is to show that new polyethylene glycol (peg) solution without electrolytes is as effective in the treatment of constipation as peg solution with electrolytes in the elderly institutionalized people. also, the tolerability and the safety of the study drug will be examined.

constipation is a major problem in elderly institutionalised patients. non-pharmacological treatments are proposed as primary management of constipation, but institutionalised patients are not likely to be able to increase either the intake of dietary fibre or fluid and their physical activity is low. the latest agent widely used for the treatment of constipation is polyethylene glycol (peg). peg is classified into the group of osmotic laxatives. it is minimally absorbed from the gastrointestinal tract and not metabolised by colonic bacteria. most of the peg products at the market contain electrolytes and have a salty and unpleasant taste which may affect the compliance of using them. a peg solution without electrolytes has been developed and used for some years in various countries. now we will compare the efficacy and safety of peg solutions with or without electrolytes and their acceptability in the use for constipation in institutionalised patients.

Eligibility criteria:
inclusion criteria: * isotonic peg treatment for constipation at the stable dose for at least 2 weeks before the run-in period exclusion criteria: * other medical treatment for constipation than isotonic peg or plantago ovata seeds * severe dementia

Keywords: constipation aged polyethylene glycol
clinical study of kdt-3594 in healthy adult males and patients with parkinson's disease

Conditions: Parkinson Disease

Summary: the purpose of this study in healthy adult males is to investigate safety and pharmacokinetics of single and multiple oral doses of kdt-3594. the purpose of this study in patients with parkinson's disease is to investigate safety and pharmacokinetics of single and multiple oral doses of kdt-3594. the exploratory efficacy of kdt-3594 will also be investigated.


Eligibility criteria:
inclusion criteria: * healthy volunteer part * healthy japanese males aged 20 to 35 years, inclusive * patient part * patients who are diagnosed with parkinson's disease according to uk parkinson's disease society brain bank clinical diagnostic criteria * patients with parkinson's disease in stages 1 to 3 on the modified hoehn and yahr scale * male patients with parkinson's disease aged 20 to 74 years inclusive, post-menopausal female patients with parkinson's disease aged 50 to 74 years inclusive exclusion criteria: * healthy volunteer part * subjects with any abnormal findings in physical examination vital signs, 12-lead ecg, clinical laboratory tests, ophthalmic examinations and electroencephalography * patient part * patients who are suspected any parkinsonism except for idiopathic parkinson's disease * healthy volunteer part and patient part * subjects who do not agree to avoid dangerous works such as driving, mechanical operation and high-place work until completion of the follow-up examination
[ga-68]mtp220 pet for biodistribution and efficacy in pancreatic cancer and head and neck cancers

Conditions: Head and Neck Cancer; Pancreatic Cancer; Cancer Pancreas

Summary: the goal of this research study is to develop a diagnostic tool to help with detection and diagnosis of head and neck cancer (hnc) and pancreatic cancer (pac). this tool is called a "targeted pet tracer", or more specifically a drug named "\[ga-68\]mtp220". the u.s. food and drug administration (fda) has not yet approved this drug, so researchers are conducting this research study to see if \[ga-68\]mtp220 is safe and effective at diagnosing pancreatic cancer and head and neck cancer. fda approval has been obtained for this study protocol by an investigational new drug (ind) application. participants will receive a single injection of \[ga-68\]mtp220 followed by pet/ct imaging at three points after they received the drug. these study procedures will take about 2.5 hours. participants will also receive a follow-up phone call the day after receiving the drug to talk about any side effects they experienced.

for hnc, the overall 5-year survival rate of hnsccs remains ∼40-50%. paca is the 3rd leading cause of cancer mortality in the us with its incidence expected to double by 2030. the poor survival of hnc and paca patients is partly due to the delayed diagnosis. thus, early detection and diagnosis is pivotal to improve the survival. currently, there is still an unmet clinical need for novel diagnostic technologies for early accurate detection and diagnosis of hnc and paca. in this exploratory first in human phase 0 trial, researchers are testing the use of a \[ga-68\]mtp220 as a targeted pet tracer to explore the biodistribution, dosimetry, efficacy and safety in pancreatic and head and neck cancer patients.

Eligibility criteria:
inclusion criteria: * participants older than 18 years old * prior biopsy showing pancreatic or head and neck malignancy * participants have been newly diagnosed and not yet received definitive therapy (including surgery, radiation therapy, or systemic therapy). * able and willing to provide written informed consent before any protocol-specific procedures are undertaken * participants willing and able to undergo a pet/ct exclusion criteria: * participants who do not meet the above mentioned inclusion criteria * participants with severe hepatic and renal dysfunction (total bilirubin \> 3 mg/dl, albumin \ 2.3 (or prolonged pt), presence of ascites or hepatic encephalopathy (grade iii-iv) end-stage renal disease (esrd) or egfr \ 4 mg/dl or rapidly rising, need for dialysis (hemodialysis or peritoneal dialysis), uremic symptoms) * participants \< 18 years old * participants who refuse to give or are unable to sign the informed consent * anti-cancer treatment (chemotherapy and/or radiation therapy) within the last 2 weeks * participants unable to withstand or undergo pet/ct * pregnant or breast feeding women.

Keywords: [ga68]mtp220 positron emission tomography computed tomography pet ct scan
trial comparing oral pilocarpine (salagen) versus submandibular salivary gland transfer protocol, for the prevention of radiation (xrt) induced xerostomia in head and neck cancer patients

Conditions: Cancer; Head and Neck Cancer

Summary: this is a study to see whether the drug salagen or salivary gland transfer is better for the prevention of dryness of the mouth in patients with head and neck cancer receiving radiation treatment.


Eligibility criteria:
inclusion criteria: 1. previously untreated and confirmed histological diagnosis of squamous cell/adenoid cystic carcinoma of the oropharynx, hypopharynx, larynx, and patients with unknown primary tumor with metastases to the neck nodes and squamous cell carcinoma of the skin of head and neck region with ipsilateral neck nodes (more than one node) metastases. 2. radiation volume to encompass \> or equal to 80% of major salivary glands (parotids and the non-transferred submandibular salivary gland) and have \> or equal to 50 gys delivered to that volume via external beam. 3. karnofsky performance score \> or equal to 70 4. minimum age 18 years 5. the patient must sign a study-specific informed consent prior to study entry 6. expected survival \> or equal to one year exclusion criteria: 1. carcinoma of nasopharynx, oral cavity, n3 disease, bilateral neck node involvement, pre-epiglottic space involvement, involvement of level 1 nodes on either side of the neck, and patients with post-operative recurrent disease. 2. salivary gland malignancy 3. salivary gland disease 4. use of anti-cholinergic drugs and tricyclic drugs 5. delay in xrt of more than 8 weeks following the curative surgery 6. pregnant or lactating females are not eligible. patients of childbearing potential should agree to use an effective method of contraception 7. prior head and neck irradiation 8. recurrent disease 9. allergy to pilocarpine 10. patients with uncontrolled asthma, acute iritis, or narrow angle glaucoma

Keywords: salagen gland transfer randomized xerostomia
changes in physical activity status: comparison of older adults with versus without a history of covid-19 infection

Conditions: Covid19

Summary: the negative impact of the covid-19 pandemic on the physical activity behavior of overall adults has been reported. but much less is known in older adults. alterations in physical activity among covid-19 survivors have not been investigated so far. the present study aimed to evaluate the physical activity status of older adults in terms of a history of covid-19 infection.


Eligibility criteria:
inclusion criteria: * 65 years non-dementia community dwelling older adults exclusion criteria: * the exclusion criteria were: (1) intensive care unit admission due to covid-19 infection, (2) neurodegenerative or psychotic disease, (3) delirium, (4) terminal illness (malignancy, advanced organ failure), and (5) hearing impairment that disrupts conducting the telephone survey

Keywords: physical activity
smartease trial: evaluating stroke help distance interventions to improve cognitive performance post-stroke

Conditions: Cognitive Impairment; Stroke

Summary: the purpose of this study is to provide evidence for the feasibility and initial effectiveness of a manualized, telephone-based (telehealth) approach to the delivery of cognitive interventions (smartease) targeted to improve cognitive performance in daily activities after stroke.

an initial brief screening interview will be completed with the potential participant by telephone to determine whether or not the individual meets the criteria for the study. in an initial onsite visit, informed consent will be obtained from both the stroke survivor and their study partner and baseline evaluations will be completed with the stroke survivor, including a baseline cognitive assessment and setting goals to work on during the study period. then the introductory section of the study handbook (making the most of your memory) which includes procedural information on the stroke help program will be reviewed with the stroke survivor and study partner. a study handbook and a large button speaker phone will be provided to the stroke survivor/partner pair to ensure that both members of the participant-caregiver team can listen to the rehabilitation coach without having to be concerned with holding a handset (an action that may be difficult for some stroke survivors). telephone contact by the rehabilitation coach will be organized and the 16-week stroke help cognitive strategy training intervention will proceed. in general the topics or strategies to be discussed will be used to achieve one or more of the following rehabilitation strategies: 1) understanding cognitive deficits that may result from stroke; 2). reinforcing, strengthening or re-establishing previously learned patterns of behavior; 3) establishing new patterns of compensatory mechanisms; 4) enabling persons to adapt to their cognitive disability. following the 16-week cognitive strategy training intervention participants will have an on-site visit to provide qualitative and quantitative data related to the feasibility and efficacy of the program.

Eligibility criteria:
inclusion criteria: * history of one or more strokes; * living in the community; * subjective concerns about cognitive function; * ability to give informed consent; * fluent in written and spoken english. exclusion criteria: * unstable medical conditions or a co-morbid neurological disorder that could additionally impact cognitive or daily function, such as parkinson's disease or multiple sclerosis; * no available caregiver or significant other willing to participate in approximately one hour of telephone contact per week with coach and stroke survivor; * current symptoms of severe depression (geriatric depression scale\>20), global aphasia, or dementia (determined by baseline testing).

Keywords: cognitive rehabilitation smart goals telehealth
an effective alternative to the standard referral system for hiv testing in the emergency department during off hour tours: a randomized trial

Conditions: HIV Counseling and Testing; HIV Infections

Summary: to compare hiv testing rates in ed patients offered video-assisted informed consent off-hours versus those referred to an hiv counselor the next business day.

ed-based hiv counseling and testing (c\&t) is in its early stages of development. most urban ed patients requesting or requiring hiv testing are referred to c\&t sites that are usually available only during regular business hours. patient compliance with these referrals has been disappointing. to improve ed access to hiv testing, we developed a video alternative to in-person pre-test counseling to provide the fundamental elements of the counseling. the video was based on the educational elements required by the new york state department of health (doh) for hiv pre-test counseling. in a previous study, we demonstrated that the educational video performed as well as live counselors in conveying the information needed for inner city ed patients to consent to hiv testing. the present study was designed to compare hiv testing rates in ed patients offered video-assisted informed consent for hiv testing versus the standard referral for live c\&t the next business day.

Eligibility criteria:
inclusion criteria: * all patients 18 years and older were approached while waiting for ed provider. exclusion criteria: * patients who were clinically unstable * unable to understand the consent process * had been hiv tested within 6 months and were informed of the result, or had a confirmed diagnosis of hiv were excluded from the study.

Keywords: hiv prevention hiv screening emergency medicine hiv counseling and testing hiv seronegativity
evaluation of the effect of web-designed training developed for asthma patients

Conditions: Asthma

Summary: the study is an experimental study with pre-test-post-test control group in order to determine the effect of web-designed training developed for asthma patients on drug compliance, asthma control, and fatigue

in the first stage, it is aimed to develop, implement and evaluate a web designed asthma education program for asthma patients. in the second stage, it is to evaluate the effect of the web-designed education program developed for asthmatic patients on drug ompliance, asthma control, and fatigue the population of the study consists of patients diagnosed with asthma who are registered in family health centers in eskişehir. the individuals that constitute the target group in the study will be determined through the records of patients diagnosed with asthma registered in the family health center or the list of patients in the j45-asthma and j46 status asthmaticus icd codes. the sample of the study will be the patients who meet the criteria for inclusion in the study. g power analysis program was used to determine the sample size. the research will be conducted in two groups, an intervention and a control group. the sample size of the research was found to be 200. in collecting research data; the personal descriptive characteristics form prepared by the researcher, the questionnaire for determining the information needs, form for evaluation of the skills of using inhalation devices and the opinion form regarding the web-based asthma education program will be used. at the same time, copd and asthma fatigue scale, drug compliance reporting scale and asthma control test (akt) will be used.

Eligibility criteria:
inclusion criteria: * 18 years and over, * those who have been diagnosed with asthma for at least one year * those with poor asthma control * using at least one asthma medication * not having a communication problem, such as inability to understand/speak turkish, that would prevent participating in the research or receiving training, * being literate, * having an internet connection at home or on their phone, * having and using a computer, tablet or smart phone, * patients who accepted to participate in the study voluntarily formed the sample of the study. exclusion criteria: * no internet connection at home or on their phone, * do not know how to use the internet and computer, * having a communication problem, such as inability to understand/speak turkish, that would prevent participating in the research or receiving training, * illiterate, * diagnosed with another respiratory system disease, * diagnosed with cancer or undergoing cancer treatment, * those who have been diagnosed with or have had covid-19, * individuals with a psychiatric illness were not included in the study.

Keywords: asthma compliance life quality asthma control web based training asthma education