Kornimate/medical-research-clean huggingface dataset:
the effect of 1 year of multiprofessional therapy on obesity

Conditions: Obesity

Summary: obese adolescents are submitted to a multiprofessional weight loss program, which is formed by doctors, nutritionists, physiotherapists, psychologists,and physiologists. the volunteers have intervention 3 times a week during one year, where they practice exercises, have nutrition and psychology counseling, and physiotherapy orientation. once a month they have an appointment with the doctor. the hypothesis of this study is that a multiprofessional therapy is able to improve anthropometric and biochemical parameters, and also the quality of life of obese adolescents.

the volunteers are submitted to 10 exams (electrocardiogram, polysomnography, blood collection, body composition, rest metabolic rate, dxa, abdominal and carotid ultrasonography, lung function evaluation, ergospirometric test) 3 times a year (baseline, middle and at the end of the year). they also answer nutrition, sleep and psychology questionnaires.

Eligibility criteria:
inclusion criteria: * present obesity ( bmi \> 95th) * aged between 15-19 years old * be able to practice exercise exclusion criteria: * pregnancy * use of drugs * secondary obesity

Keywords: obesity therapy interdisciplinary
pet/ct study in the diagnosis of coronary plaque

Conditions: Myocardial Infarction; Coronary Artery Disease; Cardiac Catheterization

Summary: this study is being done to determine if a picture taking test of the heart, positron emission tomography/computed tomography (or cardiac pet/ct), can identify the blockages in the heart arteries that lead to heart attacks when compared to the standard of heart catheterization.

heart catheterization, in which a thin plastic tube, or catheter, is placed into an artery in the arm or leg and advanced into the heart arteries, is the procedure that you and your doctor have decided to pursue to look for heart artery blockages. it is being performed as part of your standard care and not for research purposes. the research procedure (cardiac pet/ct), which will be performed at a later date is a combination of heart ct (a test that involves the use of x-rays to identify heart artery blockages) and heart pet (an imaging test that uses a radioactive drug to look at how the heart uses fuel (sugar and fats) these tests will be combined (pet/ct) to look for the presence and type of blockage in your heart arteries. it is important to develop a test that can determine if and what type of blockage you have in your heart arteries as the presence and type of heart artery blockage is a very important predictor of heart attack and death from heart attack.

Eligibility criteria:
inclusion criteria: * 18 years oof age or older * referred for cardiac catheterization. * coronary artery disease that does not need angioplasty. exclusion criteria: * history of cardiac stents * bypass surgery * bad kidney function * unable to take beta blocker medication * history of asthma * allergies to egg containing products * atrial fibrillation * pregnancy * breastfeeding * overweight by definition of a bmi over 35.

Keywords: pet ct heart attack coronary artery disease cardiac catheterization
nexavar dosing in renal cancer patients in "real-life" setting

Conditions: Carcinoma, Renal Cell

Summary: this study is a registry of renal cancer patients treated with nexavar. it aims to evaluate the actual dosing of nexavar in "real-life" setting vs. the prescribed dose.


Eligibility criteria:
inclusion criteria: * age \>/= 18 years * diagnosis of renal cell carcinoma * failure of prior therapy with interferon-alfa (ifn) or interleukine-2 (il-2) or disqualified from therapy with ifn/il-2 * patients in whom the oncologist has decide to start therapy with sorafenib. exclusion criteria: * synonymous with contraindications to nexavar.

Keywords: renal cell carcinoma, sorafenib dosing
identification and treatment of alcohol problems in primary care

Conditions: Alcohol Abuse Alcoholism; General Practice; Screening and Brief Intervention

Summary: the identification and treatment of alcohol problems in primary care (itapp) study is a pragmatic cluster randomized controlled intervention trial evaluating the effectiveness of the 15-method as an identification and treatment tool for alcohol-related problems in danish general practice. the 15-method combines evidence-based approaches from specialized addiction treatment with screening and readily available treatment options in general practice to help identify and treat alcohol problems in a primary care setting. the method has shown promising results as a treatment tool in sweden. a feasibility study of the 15-method in denmark suggested that the method can be implemented in danish general practice. the trial is led by the unit for clinical alcohol research at the university of southern denmark in collaboration with the research unit of general practice odense at the university of southern denmark.


Eligibility criteria:
inclusion criteria: * 18 years or older * affiliated with the participating general practices exclusion criteria: - none

Keywords: primary care screening alcohol use disorder
study of nms-1116354 in solid tumors

Conditions: Advanced Solid Tumors

Summary: the purpose of this study is to evaluate the safety profile of nms-1116354, a cdc7 kinase inhibitor, in adult patients with advanced solid tumors.


Eligibility criteria:
inclusion criteria: 1. advanced/metastatic solid tumors, for which no alternative effective standard therapy is available 2. maximum of 4 regimens of prior cancer therapy allowed 3. prior radiotherapy allowed if no more than 25% of bm reserve irradiated 4. resolution of all acute toxic effects (excluding alopecia) of any prior anticancer therapy 5. ecog performance status (ps) 0 or 1 6. adult (age \>/= 18 and \</= 80 years) patients 7. adequate renal, liver and bm reserve 8. capability to swallow capsules intact exclusion criteria: 1. current enrollment in another therapeutic clinical trial 2. known brain metastases 3. currently active second malignancy 4. major surgery within 4 weeks prior to treatment 5. any of the following in the past 6 months: myocardial infarction, unstable angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure, cerebrovascular accident or transient ischemic attack, pulmonary embolism, deep vein thrombosis 6. pregnancy or breast-feeding women 7. known active infections 8. gastrointestinal disease or other malabsorption syndromes that would impact on drug absorption 9. adrenal insufficiency 10. other severe acute or chronic medical or psychiatric condition that could compromise protocol objectives

Keywords: phase i study advanced solid tumors cdc7 kinase inhibitor
does treatment with alfuzosin increase success rates of (swl) shock wave lithotripsy

Conditions: Urolithiasis; Nephrolithiasis; Ureterolithiasis

Summary: in latest literature more evidence is available about the positive effect of alpha blocker on stone expulsion from the ureter. patients benefit from less pain and shortening time to stone expulsion. our study is design to evaluate whether alfuzosin improves the stone free out come following swl.

all patients undergoing swl are included in study. exclusion criteria: patient with radio-lucent stone, patients treated with calcium channel blockers, alpha blockers, steroids, patients with contraindication to alpha blocker treatment, postural hypotension patents with abnormal liver function tests. patient will be recruited to the study prospectively. following signature on inform consent patients will be randomized into 2 groups. one group will be treated with alfuzosin 10mg a day and the control group with placebo. treatment will be initiated following the lithotripsy treatment. parameters for investigation includes: demographic and personal data, stone size and location (obtained by ct or kub), pain control medication and visual analogue scale assessment of pain, side effects, clinical squeals, stone free out come. follow up evaluation will be at 1 week, 1 month, and 3 months post treatment. success will be defined following ct evaluation at 3 months. treatment ends at stone free achievement or at 3 months. endpoints:stone free rate, time to stone free, side effect.

Eligibility criteria:
inclusion criteria: * patients undergoing shock wave lithotripsy treatment for urolithiasis. exclusion criteria: * patients with abnormal liver function, postural hypotension, alpha-blocker treatment, sensitivity to alpha-blockers, radio-lucent stone, calcium channel blocker treatment, steroids treatment.

Keywords: swl lithotripsy stone disease urolithiasis nephrolithiasis
evaluation of robot-assisted surgery in gynecologic oncology

Conditions: Gynecologic Cancer

Summary: the goal of this observational study is to collect information about the length of surgery, the procedures performed during surgery, and any possible side effects of robot-assisted gynecologic cancer surgeries. the researchers also want to learn if patients who have robot-assisted surgeries have fewer complications during recovery.

information collection: if you agree to take part in this study, the following information will be collected from your medical record after surgery: * the reason you had or are scheduled to have robot-assisted surgery. * how long the surgery took to complete. * what procedures were performed during the surgery. * if cancer was or was not found in the tissue that was removed. * how long you were in the hospital. * what complications, if any, happened that are related to the surgery. follow-up questionnaires: depending on when you enroll in the study, you may be asked to complete a short questionnaire 3 different times, each questionnaire will take less than 10 minutes to complete. if you had surgery for cervical cancer, you will complete the questionnaire 2 weeks after surgery. all patients will complete the questionnaires 4-6 weeks after surgery, and again 3-6 months later. if you have your follow up care with a doctor outside of md anderson, you will be called to complete the questionnaires over the phone. each phone call should last about 10 minutes this questionnaire and/or phone calls will ask questions about any side effects you have experienced that you think may be related to the surgery. length of study: after the last questionnaire is completed, your participation in the study is over. this is an investigational study. up to 1,000 patients will take part in this study at md anderson cancer center and banner md anderson arizona.

Eligibility criteria:
inclusion criteria: 1) all women who have undergone or will undergo a robotic-assisted gynecologic procedure at md anderson cancer center and md anderson banner - arizona are eligible for inclusion in this study. they should be able to speak either english or spanish. exclusion criteria: 1) none

Keywords: gynecologic cancer cervical cancer endometrial cancer fallopian tube cancer ovarian cancer uterine cancer vaginal cancer vulvar cancer questionnaire survey robot-assisted surgery
development of fapi pet as a non-invasive biomarker of pulmonary fibrogenesis

Conditions: Fibrosis Lung

Summary: the goal of this clinical trial is to gain more information about how fibroblast activation protein inhibitor (fapi) binds to a certain type of cells in fibrotic lung tissue and how this information can be used to better diagnose and track fibrotic lung disease activity. participants will undergo up to 4 pet/mri scans using the fapi radiotracer.

researchers aim to develop a non-invasive pet/mri imaging tool using fapi as a pet radiotracer and mri to assess the presence and extent of fibrogenesis (the process that leads to fibrosis and scarring) in the lungs.

Eligibility criteria:
inclusion criteria: * age 18 years or older * able and willing to provide informed consent * clinically evaluated for need for initiation of new treatment (in patients not on current treatment), initiation of change in current treatment, or addition of new treatment (to any current treatment) in the setting of fibrotic hypersensitivity pneumonitis (hsp) or idiopathic pulmonary fibrosis (ipf), per standard of clinical care at uw health. * willing and able to undergo pet/mri. * participants requiring intravenous (iv) conscious sedation for imaging are not eligible; participants requiring mild, oral anxiolytics for the clinical mri will be allowed to participate as long as the following criteria are met: * the subject has their own prescription for the medication * informed consent is obtained prior to the self-administration of this medication * they come to the research visit with a driver exclusion criteria: * participant is unable or unwilling to provide informed consent * participant is pregnant * participant with contraindication(s) to or inability to undergo pet/mri * participants with contraindications to gbca will be asked to undergo research imaging without the use of contrast. contraindications may be severe kidney disease or previously documented gfr \< 30 ml/min/1.73 m2

Keywords: lung disease associated with fibrosis
activator vs the ef class ii standard in the treatment of severe overjet in angle class ii division 1 malocclusion

Conditions: Class II Division 1 Malocclusion

Summary: objective: the purpose of this study was to compare the clinical effectiveness of reducing severe overjet in angle class ii division 1 malocclusion between activator and the ef (functional education) class ii standard in treating. methods: a randomized clinical trial was conducted on a total of ̉60 patients with an angle class ii, division 1 malocclusion (anb angle ≥ 4°, basic normal maxillary status), and an overjet of ≥ 6 mm in the developmental stage (cs1-cs3) who were eligible for the study. thus, the sample consisted of 60 subjects (29 girls and 31 boys) with a mean age of 9.7 ± 1.31 years. the investigators designed the study to treat patients, randomly assigning them by lottery to receive either an activator or the ef (functional education) class ii standard. the activator versus the ef (functional education) class ii standard group consisted of 30 subjects (17 girls, 13 boys) and 30 subjects (12 girls, 18 boys), respectively. the changes in skeletal, dental, and soft tissue were recorded before, at 6 months of treatment. blinding was not performed. after six months of treatment, the study's endpoint was reached.

a randomized clinical trial was conducted on a total of ̉60 patients with an angle class ii, division 1 malocclusion, and an overjet of ≥6 mm who were eligible for the study. thus, the sample consisted of 60 subjects (29 girls and 31 boys) with a mean age of 9.7 ± 1.31 years. we designed the study to treat patients, randomly assigning them by lottery to receive either an activator or the ef (functional education) class ii standard. the activator versus the ef (functional education) class ii standard group consisted of 30 subjects (17 girls, 13 boys) and 30 subjects (12 girls, 18 boys), respectively. the changes in skeletal, dental, and soft tissue were recorded before, at 6 months of treatment. blinding was not performed. after six months of treatment, the study's endpoint was reached and then selected those who achieved the standards for sampling at can tho university of medicine and pharmacy. the can tho university of medicine and pharmacy ethics council in biomedical research no. 23. 340.hv/pct-h signed the study on april 12, 2023.

Eligibility criteria:
inclusion criteria: * vietnamese children between the ages of 7 and 12 with central incisors erupted * angle class ii division 1 malocclusion (anb angle ≥ 4°, basic normal maxillary status) * severe overjet ≥ 6mm * the developmental stage (cs1-cs3) * no previous orthodontic treatment * agreeing to engage in the study exclusion criteria: * the young with crossbite * severe crowding

Keywords: angle cii division 1, activator, ef cii standard, severe oj
pemocs: personalized motor-cognitive training in chronic stroke

Conditions: Stroke

Summary: in switzerland, approximately 20'000 persons suffer a stroke each year. despite carefully considered rehabilitation programs, full recovery is achieved only in a small proportion of stroke survivors (www.swissheart.ch). studies suggest that motor-cognitive trainings can improve gait, balance, and mobility in chronic stoke survivors. however, little is known about the effect of motor-cognitive trainings on cognitive functioning in chronic stroke. the aim of this study is to evaluate the effects of a motor-cognitive training added to usual care compared to usual care alone on cognitive functions, single- and dual-task mobility, gait and health-related quality of life. in this single-blind rct, 38 participants will be allocated randomly to either the intervention group (usual care + motor-cognitive training by means of an exergame for 12 weeks, 2x/week for 30-40 minutes) or the control group (usual care only). both groups will attend three assessments, at baseline, post-intervention (12 weeks after baseline), and at follow-up (24 weeks after baseline). global cognitive functioning will be the primary endpoint and a linear mixed model will be used for analysis. motor-cognitive trainings, especially exergames, bear the potential for further development of innovative long-term rehabilitation solutions for chronic stroke survivors. cognitive deficits are a common unmet need restricting daily activities mentioned by chronic stroke survivors. exergame training following personally tailored progression to generate optimal training load may help addressing this unmet need. therefore, this study will contribute to the on-going research objective on how to improve the long-term care of stroke patients.


Eligibility criteria:
inclusion criteria: * adults (\> 18 years) with chronic stroke (≥ 6 months post-stroke) * stroke: ischemic or haemorrhagic * able to stand for 3 minutes and walk 10 meters, functional ambulation category ≥ 3 * able to follow a two-stage command * able to give informed consent as documented by signature exclusion criteria: * unable or not willing to give informed consent * other neurological diseases (e.g. parkinson's disease, multiple sclerosis), except cognitive deficits or dementia * clinical contra-indications for the study intervention * unable to follow the study intervention or the test for the primary endpoint (moca), e.g. due to a neglect, aphasia or other language problems * overlapping enrolment in another clinical trial

Keywords: cognition gait mobility training chronic stroke rehabilitation virtual reality
description of sign-and-symptom associations at acromegaly diagnosis.

Conditions: Acromegaly

Summary: the purpose of this study is to describe most characteristic association of signs and symptoms present at the time of acromegaly diagnosis.


Eligibility criteria:
inclusion criteria: * adult patient (greater than or equal to 18 years old) * patient with acromegaly, diagnosed for less than 5 years exclusion criteria: * patient who have objected to the collection of his/her data
effectiveness and tolerability of the on-demand use of combined dapoxetine with tadalafil and combined dapoxetine with lidocaine 5% spray in treatment of patients with lifelong premature ejaculation and non-responding to dapoxetine alone.

Conditions: Premature Ejaculation

Summary: therefore, this study will aim to assess the effectiveness and tolerability of the on-demand use of combined dapoxetine with tadalafil and combined dapoxetine with lidocaine 5% spray in treatment of patients with lifelong premature ejaculation and non-responding to dapoxetine alone.

this study will be carried out on 60 patients with lifelong premature ejaculation and non-responding to dapoxetine alone. all patients will be equally divided into 2 groups (30 patients each). group 1 was given on-demand 30 mg dapoxetine and 10 mg tadalafil 1 h before intercourse. group 1 was given on-demand 30 mg dapoxetine 1 h before intercourse and apply lidocaine 5% spray on the glans penis 10 minutes the wash before intercourse.

Eligibility criteria:
inclusion criteria: * lifelong premature ejaculation and non-responding to dapoxetine alone. exclusion criteria: * diabetes mellitus, * chronic prostatitis, * advanced renal or hepatic diseases * neurological diseases * c.n.s. medications

Keywords: premature ejaculation
effect of different doses of dexmedetomidine on cerebral oxygen saturation and postoperative anxiety in elderly patients

Conditions: Anxiety

Summary: to investigate the effect of different doses of dexmedetomidine on cerebral oxygen saturation and postoperative anxiety in elderly patients undergoing laparoscopic surgery

a total of 105 patients who were admitted to the first hospital of qinhuangdao for laparoscopic surgery and divided into control group (group c), dexmedetomidine doses of 0.2 μg/kg (group d1), dexmedetomidine doses of 0.5 μg/kg (group d2). 105 patients were randomized equally into 3 groups. 35 cases in each group. group c received general anesthesia without dexmedetomidine, groups d1 received general anesthesia with intravenous pump of 0. 2μg/kg/h dexmedetomidine, groups d2 received general anesthesia with intravenous pump of 0. 5μg/kg/h dexmedetomidine.sbp(systolic blood pressure),dp(diastolic pressure),hr(heart rate) and rsco2(regional cerebral oxygen saturation) of the three groups were recorded before anesthesia induction (t1), at the time of intubation (t2), five minutes after induction(t3),at the beginning of surgery (t4), immediately after surgery (t5), and five minutes after extubation (t6). the cognitive function of the three groups was assessed with the mini mental state scale (mmse) on the day before surgery. the anxiety of the three groups was assessed with self-rating anxiety scale (sas) on the day before surgery,one day after and three days after surgery, comparing the incidence of anxiety between the three groups. analyze whether dexmedetomidine reduced the incidence of anxiety by increasing cerebral oxygen saturation.

Eligibility criteria:
inclusion criteria: * patients aged 65 years or older who underwent elective laparoscopic surgery under general anesthesia * bmi less than 30 kg/m2 * american society of anesthesiologists (asa) grades i-iii * the score of mini mental state examination≥24 exclusion criteria: * patients with heart, lung and other vital organ disorders * the score of mini mental state examination≤23 * preoperative psychiatric disorders or long-term use of drugs affecting the psychiatric system * have severe visual, hearing, speech impairment or other inability to communicate with the visitor * refuse to sign informed consent * known preoperative left ventricular ejection fraction less than 30%, sick sinus syndrome, severe sinus bradycardia (\<50 beats per min \[bpm\]), or second-degree or greater atrioventricular block without pacemaker

Keywords: dexmedetomidine anxiety