Kornimate/medical-research-clean huggingface dataset:
saraiki translation, validity & reliability of the activities specific balance confidence (abc) scale questionnaire

Conditions: Old Age; Debility

Summary: there is a need for a culturally adapted screening tool to aid health care professionals or clinicians screen for the presence of fall and balance issues associated with injuries in saraiki population. furthermore, while culturally adapting the scale is necessary, it is important that changes do not alter the original intent, which requires it to be broad, comprehensible and applicable to the entire population. as saraiki language is the most-used language in the south punjab, translating and adapting the abc scale to the saraiki population while accounting for its sociocultural characteristics is an important task. so, i decided to conduct a tool translation and validation study. this study will help the clinicians to assess their patient's confidence and balance easily through the saraiki version of abc scale in saraiki population and hence will help in timely management of the balance.

the abc scale is a 16-item questionnaire with 11-point subscales that assess the level of confidence in performing a specific task without losing balance or becoming unsteady. each item score ranges from 0% (no confidence) to 100% (total confidence). as cross-border and cross-cultural studies continue to increase, there is a greater need for linguistic validation of tools across a variety of societies. until now, no translation or adaptation of the abc scale has been made for the population with different languages in pakistan. in order to use questionnaires in areas with different languages and cultures, translation into new languages of abc scale, for identifying fall and balance issues is required.

Eligibility criteria:
inclusion criteria: * able to read saraiki language. * healthy older population * people with controlled diabetes mellitus * people with controlled hypertension * older adults with bbs score 45-56. exclusion criteria: * unstable medical condition. * cognitive issues like not able to concentrate, can't perform the task attentively. * any physical disability like not able to walk and patient with vestibular disorders.

Keywords: balance older adults
effect of kinesiotaping and night splinting in patients with carpal tunnel syndome

Conditions: Carpal Tunnel Syndrome

Summary: carpal tunnel syndrome (cts) which is defined as a symptomatic compression neuropathy of the median nerve at the level of the wrist. different types of splints are used for improving the function and decreasing the pain intensity and symptoms in the rehabilitation of patients with cts. however effectiveness of treatment by taping has never been investigated in physiotherapy and rehabilitation. the aim of this study was to compare the short-term effect of conventional physiotherapy only, and also kinesio taping and night splinting in patients with cts.

carpal tunnel syndrome (cts) which is defined as a symptomatic compression neuropathy of the median nerve at the level of the wrist.it is considered as the most common disabling neuromuscular condition of the upper extremities. night splints are used in conjunction with the conservative intervention to improve the function and decrease the pain intensity and paresthesia in the rehabilitation of patients with carpal tunnel syndrome. however effectiveness of treatment by kinesiotaping has never been investigated. the aim of this study was to compare the short-term effect of conventional physiotherapy only, and also kinesio taping and night splinting in addition to conventional physiotherapy in the rehabilitation of patients with cts.

Eligibility criteria:
inclusion criteria: * this study included patients with moderate cts, confirmed by electroneurographic examination. * did not recruit any treatment (including physiotherapy or surgical release) exclusion criteria: * patients suffer from the thenar muscle atrophy. * patients with mild cts.

Keywords: carpal tunnel syndrome night splinting kinesiotaping physiotherapy and rehabilitation
local effects of amino acids and 3-hydroxybutyrate in the bilaterally perfused human leg

Conditions: Critical Illness; Protein Metabolism; Pharmaconutrients

Summary: introduction: protein loss during critical illness is an important problem and is shown to predict overall survival. in animal studies, infusion of leucine is shown to increase the synthesis of muscle protein by 30-40% and decrease protein degradation by 30%. objectives: compared to saline, an amino acid or 3hydroxybutyrate infusion in the femoral artery will promote protein synthesis and inhibit breakdown assessed with local a/v phenylalanine and tyrosine tracer kinetics in healthy volunteers. these effects will include distinct alterations in muscle signal events, in particular mtor. methods: n = 10 healthy male subjects are equipped with catheters in aa. femorals and vv. femorals bilaterally under local anaesthetics. each study comprises a 3-hour basal period and a 3-hour period with hyperinsulinaemic-euglycaemic clamp. during the test, samples of arterial and venous blood and 4 muscle biopsies are obtained. the intervention contain continues saline infusion compared to either amino acids (vamin) or 3hydroxybutyrate solution ffa-3ohb. perspectives: this study elucidates the direct effect of aminoacids and ketone bodies on muscle protein metabolism in humans and contribute to further development of nutritional therapy in human catabolic states.


Eligibility criteria:
inclusion criteria: * bmi between 19 and 28 * written consent before study start exclusion criteria: * diabetes * inclusion in other studies using ionizing radiation. * allergic to egg or soy

Keywords: critical illness protein metabolism pharmaconutrients
registry of mastectomy for breast cancer risk reduction

Conditions: Quality of Life; Mastectomy; Breast Neoplasms; Genetic Predisposition to Disease; Adjustment Disorder

Summary: this is a registry for patients who have a risk-reduction mastectomy ("prophylactic mastectomy") due to being at high risk for developing breast cancer, followed by breast reconstruction. eligible patients include those who have a breast cancer-related gene, a strong family history of breast cancer, or a personal history of high-risk conditions such as cancer in the other breast or ductal carcinoma in situ (dcis). patients are enrolled in the registry before surgery, and are followed for up to ten years afterwards. in addition to studying medical outcomes, we will periodically survey patients for quality-of-life issues and psychological well-being. there is no compensation for being enrolled in this registry. this registry is conducted through the department of plastic surgery at georgetown university hospital, and is a sub-registry to the fisher familial cancer registry at the lombardi comprehensive cancer center at georgetown university.


Eligibility criteria:
inclusion criteria: * patients at an elevated risk for breast cancer. exclusion criteria: * none.

Keywords: prospective study registry quality of life mastectomy reconstructive surgical procedures brca1 brca2 breast cancer prevention
support for the resumption of training of high-level athletes post-epidemic covid-19

Conditions: COVID-19; Myocarditis

Summary: as of march 2020, covid-19 has become a global pandemic, halting athletic competition worldwide. reports from china show a high prevalence of cardiac involvement in patients with severe sars-cov-2 infection. these cardiac forms were found to be closely associated with adverse outcomes. the use of magnetic resonance imaging (mri) had allowed to show that cardiac dysfunction could be mediated by myocardial inflammation (i.e. myocarditis). the direct implication of the virus was demonstrated with severe acute respiratory syndrome (sars)-cov-2 being detected on myocardial biopsies in a patient with severe heart failure. the experience with other viruses causing acute myocarditis shows that there is a high rate of undetected injuries. indeed, although severe heart failure can be present at the acute stage, acute viral myocarditis is most commonly pauci or asymptomatic, but still leaving occult myocardial scars visible on mri, and exposing to higher risks of ventricular arrhythmia and sudden cardiac death over the long term. although athletes are younger and have fewer comorbidities than the general population and therefore are at lower risk for severe disease or death, there is a critical and urgent need to assess the prevalence of occult scars in the population of high-level athletes returning to training after the sars-cov-2 pandemia.


Eligibility criteria:
inclusion criteria: * high level athlete, * of both sexes and age ≥ 18 years, * affiliated to or beneficiary of a social security system, * free, informed, written consent signed by the participant and the investigating physician (no later than the day of inclusion and before any examination required by the research), * effective method of contraception for women with childbearing capacity. exclusion criteria: * minor, * history of ventricular arrhythmia, myocarditis, identified coronary artery disease or documented myocardial fibrosis, * pregnant or breastfeeding women, * person unable to give informed consent, * person deprived of liberty by judicial or administrative decision, * adults subject to a legal protection measure (guardianship, curator, safeguard of justice). specific exclusion criteria for the mri component (contraindications): * subject with an implantable pacemaker or defibrillator, intraocular metallic foreign body, intracranial metallic clip, pre 6000 starr-edwards type cardiac valve prosthesis, or biomedical device such as insulin pump or neurostimulator, * hypersensitivity to gadolinium or to one of the excipients of the contrast product used, * claustrophobic subjects or those unable to remain in an immobile lying position for 30 minutes, * renal insufficiency with creatinine clearance of less than 30 ml/min, * a patient whose shoulder width does not allow installation in the mri machine.

Keywords: myocardial scars mri ventricular arrhythmia sudden cardiac death high-level athletes
effectiveness of nutritional supplementation in preventing malnutrition in children with infection

Conditions: Malnutrition; Malaria; Lower Respiratory Tract Infection; Diarrhoea

Summary: the purpose of this study is to determine whether 14 days nutritional supplementation with ready to use therapeutic food (rutf) or micronutrients alone to children having an infection will prevent malnutrition and reduce the frequency of morbidity.

anorexia due to infection might lead to weight loss. in many settings total recovery is problematic what might result in a permanent lower weight. a short period high quality food supplementation could improve weight gain after an infection. a complete high quality food will be tested, but also micronutrients alone as there is no information on what children with an infection exactly need as a supplement. children aged 6-59 months presenting with diarrhoea, malaria or lower respiratory tract infection (lrti) are provided for 2 weeks with * rutf supplement (plumpynut®) of 500 kcal/day * multi-micronutrient powder (mnp) * placebo to mnp the followup period is 6 months. anthropometric indicators and morbidity are assessed monthly. participants are invited to attend the study clinic if any signs of disease are noticed.

Eligibility criteria:
inclusion criteria: * 6 to 59 months of age * not malnourished or moderately acutely malnourished children * diagnosis of malaria and/or diarrhoea and/or lrti * intending to remain in area for the duration of the 6 month follow-up * living within approximately 60 minutes walking distance from the clinic * informed consent from a guardian\* exclusion criteria: * child is exclusively breastfeeding * child is severely malnourished * presence of 'general danger signs' * presence of severe disease (including severe malaria, severe lrti, severe diarrhoea) * needing hospitalisation for any reason * known history of allergy to the nutritional supplementation * having a sibling enrolled in the study\*

Keywords: supplementation rutf micronutrients plumpynut mixme sprinkles convalescence weight morbidity
effects of sand treatment on osteoarthritis

Conditions: Osteo Arthritis Knee

Summary: 2528/5000 historically the city of guarapari / es is known as the city health by the popular therapeutic effect of its sands in diverse diseases. the articular diseases are among the list of the aggravations that popularly the monazitic sands exert some therapeutic effect, emphasizing. rheumatic diseases include osteoarthritis of the knee. it is a disease with a high prevalence and in recent years have presented an increase in the incidence supposedly caused by the aging population and due to the epidemic of obesity. osteoarthrosis is proven to be a disease that leads to the incapacity and restriction of the individual's ability to come and go with high monetary costs for the patient and the government. in view of these facts presented, the objective is to investigate the therapeutic potential of monazite sands in elderly patients submitted to serial, controlled and standardized exposure, compared to patients exposed to beach sand without radiation.

a sample of 150 patients with primary knee osteoarthrosis will be selected for the study, divided into two random groups that will be exposed to sand (one monazite sand group and another beach sand group without radiation) for 12 months. the groups will be evaluated at time 0 (at the patient's arrival in the group) and at 1, 2, 3, 6, 9 and 12 months of exposure following the literature criteria for evaluation of knee osteoarthrosis (visual analogue scale (eva) and western ontario and mcmaster universities osteoarthritis index (womac)) and non-specific and specific biomarkers (c-reactive protein, erythrocyte sedimentation rate, il-1β, il-6, il-8, tgf-β, and tnf-α). in addition, the groups will undergo an initial interview and monitoring of the pharmacological therapies used prior to the study and during the months of follow-up using the dáder methodology of pharmaceutical care adapted to the study. as a result, the scientific evidence of the efficacy of monazitic sands in knee osteoarthrosis is expected not only by clinical criteria but also by laboratory evidence on the markers of the inflammatory and degenerative process that allow us to document the real value of the monazitic sands for health of the population, to establish a great line of research for the state of espírito santo and to value the state of espírito santo and the municipality of guarapari as potential itineraries for spa tourism (aiming to improve health).

Eligibility criteria:
inclusion criteria: * joint pain related to daily activities; * no morning joint stiffness greater than 30 minutes; * age between 30 and 95 years. exclusion criteria: * history of previous knee surgery. * history of fracture in the knee region. * history of any secondary oa associated with any cystic arthropathy. * any treatment for the knee with methotrexate. * history of hemorrhagic disorders. * history of any infiltration of the knee during the previous 6 months (eg corticosteroids and hyaluronic acid). * morbid obesity. * history of severe psychiatric disorders. * history of skin cancer.

Keywords: monazitc sands radiation
dose-escalated spine sbrt for localized metastasis to the spinal column

Conditions: Spine Metastases; Metastasis Spine

Summary: this study is being done to determine the feasibility and tolerability of a novel regimen of spine stereotactic radiosurgery (ssrs). ssrs delivers high doses of radiation to tumors of the spine using precision techniques. in standard medical care, conventional ssrs is delivered in only 1 or 2 treatments. when this treatment is delivered in only 1-2 treatments, a high dose is used which can increase the side effects of treatment. this study aims to test an alternative technique of delivering ssrs over 5 treatments. by delivering the radiation therapy over multiple treatments, the dose of radiation is less per treatment.

given the limitations with conventional external-beam radiotherapy, spine stereotactic radiosurgery was developed as an alternative treatment for localized spine metastasis. stereotactic radiosurgery is an alternative treatment option to conventional palliative radiotherapy, which has gained acceptance over the last decade. clinical experience with spine stereotactic radiosurgery has showed high rates of pain control and improvement in neurological function in patients with epidural compression.

Eligibility criteria:
inclusion criteria: * zubrod performance status 0-2 * localized spine metastasis from a solid tumor from the c1 to l5 levels (a solitary spine metastasis, two separate spine levels, or up to 3 separate sites; each of the separate sites may have a maximal involvement of 2 contiguous vertebral bodies) * patients with epidural extension are eligible as long as there is a ≥ 2 mm gap between the spinal cord and the edge of the epidural lesion * paraspinal disease extension is allowed as long as it measures ≤ 5 cm in the greatest dimension and that it is contiguous with the spine metastasis * for patients enrolled in cohort 2, the minimum time to re-irradiation should be 6 months * numerical rating pain scale (nrps) score of ≥ 5 at the index site(s) (as rated when the patient is not taking pain medication) exclusion criteria: * radiosensitive histologies (myeloma, lymphoma, germ cell tumors, small cell lung cancer) * non-ambulatory patients * \>50% loss of vertebral body height or spinal instability to due pathologic compression fracture * frank spinal cord compression, spinal cord displacement, or epidural extension within 2 mm of the spinal cord * rapid neurologic decline * patients for whom an mri of the spine is medically contraindicated * pregnant women

Keywords: localized metastasis spinal column
tts esophageal hilzo stent: a safety and feasibility study

Conditions: Esophagus Cancer

Summary: a multicenter non-randomized prospective clinical study assessing the safety and feasibility of the esophageal through-the-scope hilzo covered self-expandable metal stent placement for palliation of malignant dysphagia

the main objective of this study is to evaluate the safety and efficacy of placement of the esophageal hilzo covered stent with the tts method in patients with non-operable malignant obstruction of the esophagus or esophagogastric junction, extrinsic malignant compression, or recurrent malignant dysphagia after esophagectomy. other (secondary) objects are to assess the effect of the stent on the presence of hyperplastic reaction after implantation, the functional complications and survival.

Eligibility criteria:
inclusion criteria: * non-operable malignant obstruction of the esophagus or esophagogastric junction, extrinsic malignant compression, or recurrent malignant dysphagia after esophagectomy. a tumor is considered inoperable if the patient has local tumor infiltration in the surrounding organs, distant metastases or a poor general health due to serious concomitant disease. or * recurrent dysphagia after prior radiation with curative or palliative intent for esophageal or gastric cardia cancer. * requiring treatment for dysphagia (dysphagia score of ≥ 2, according to ogilvie2) * written informed consent * age ≥ 18 years exclusion criteria: * inappropriate cultural level and understanding of the study. * simultaneous participation in another clinical study * life expectancy of less than 12 months * stenosis after laryngectomy, or if the distance between the upper edge of the stent is less than 2 cm from the upper esophageal sphincter * tumor length of more than 12cm * previous stent placement for the same condition
evaluation of medium chain triglycerides in a mixed racial population of patients: a feasibility study

Conditions: Insulin Resistance

Summary: the study team will investigate the racial differences in the metabolic and clinical responses to medium chain triglycerides (mct) between african american and caucasian american subjects.

it is generally accepted that type 2 diabetes (t2d) arises from the progression of insulin resistance (ir), with hyperinsulinemia (hi) as a compensatory response. the possibility that hi can precede and contribute to insulin resistance (ir) and metabolic syndrome (ms) has been suggested but not tested in humans. while ir and hi are closely associated, demonstrating a primary role for hi in t2d is key to the development of new treatment strategies for this disease. one group in which hi could play a bigger role in t2d is african americans (aa) who are known to be more hyperinsulinemic than caucasian americans (ca). racial disparities in t2d treatment outcomes adversely affect aa. our main hypothesis is that suppression of hi will contribute to the prevention and treatment of t2d, especially among aa. our goal in this pilot study is to show that consumption of medium chain triglycerides (mct) in the diet will decrease basal insulin secretion and hi, and will lead to improvement in the insulin sensitivity index (si). 24 subjects (12 aa, 12 ca) will participate in a clinical trial in which they will receive mct for 6 weeks. insulin secretion dynamics and insulin sensitivity will be assessed by use of the frequently sampled intravenous glucose tolerance test (fsivgtt) and bergman's minimal model analysis.

Eligibility criteria:
inclusion criteria: * english-speaking * males and female ambulatory subjects * self-identify as caucasian/white or black/african american * body mass index \<=45 exclusion criteria: * diagnosis of type 2 diabetes or hemoglobin a1c \>6.5 * use of insulin, oral hypoglycemic, agents, or insulin-sensitizing agents * daily use of oral steroids * unstable weight within 3 months prior to baseline (e.g., weight gain or loss of \>3%) * use of any weight loss medications or sex hormone therapy * daily use of psychotropic medications (for schizophrenia, bipolar disorder, obsessive compulsive disorder, posttraumatic stress disorder, psychotic disorder, mania) * chronic kidney disease, on dialysis or history of renal transplant * poorly controlled cardiovascular disease or congestive heart failure * severe peripheral vascular disease or severe liver disease * cancer * a condition requiring use of oxygen such as severe chronic obstructive pulmonary disease * women who are pregnant, lactating, or actively trying to become pregnant * any cognitive or other disorders that may interfere with participation or ability to follow restrictions * abnormal tsh levels (\ 1.5x the upper limit) * weight \>450 lb (205 kg) or height \> 6'6" * severe claustrophobia * has had or is preparing for bariatric surgery (pre- or post-bariatric) * medically required use of anticoagulant therapies * current use of mct oil * anemia (hemoglobin and/or hematocrit outside sex-specific normal ranges)

Keywords: hyperinsulinemia