Kornimate/medical-research-clean huggingface dataset:
a study on adding precisely targeted radiation therapy (stereotactic body radiation therapy) to the usual treatment approach (drug therapy) in people with breast cancer

Conditions: Oligometastatic Breast Carcinoma; Breast Cancer; Metastatic Breast Cancer; Metastatic Breast Carcinoma; ER+ Breast Cancer; HER2+ Breast Cancer

Summary: the purpose of this study is to see if using stereotactic body radiation therapy/sbrt to treat a single metastatic site where cancer has worsened may be an effective treatment for people with oligometastatic breast cancer. participants will stay on their usual drug therapy while they receive sbrt. this combination of sbrt to a single metastatic site and usual drug therapy may prevent participants' cancer from worsening in other metastatic sites or spreading.


Eligibility criteria:
inclusion criteria: * age 18 or older * willing and able to provide informed consent * metastatic breast cancer, biopsy proven * er+/her2-, defined as \>5% er+ staining * her2+ (regardless of er status), including her2-low and high expressors * history of at least 6 months, sustained response to systemic therapy (clinically or radiographically defined as complete or stable response without progression) * isolated site of disease progression on fdg pet scan * consented to 12-245 * ecog performance status 0-1 exclusion criteria: * pregnancy * serious medical comorbidity precluding radiation, including connective tissue disorders * intracranial disease (including previous intracranial involvement) * previous radiotherapy to the intended treatment site that precludes developing a treatment plan that respects normal tissue tolerances.

Keywords: oligometastatic breast cancer breast cancer er+ breast cancer her2+ breast cancer metastatic breast cancer stereotactic body radiation therapy 22-259 memorial sloan kettering cancer center
evaluation of the effects of carperitide in patients with congestive heart failure

Conditions: Heart Failure, Congestive; Heart Decompensation; Left Ventricular Failure; Myocardiopathies; Systolic or Diastolic Left Ventricular Dysfunction

Summary: the study will evaluate the safety and efficacy of intravenous infusion of carperitide using pressure measurements inside the heart and great vessels and measuring carperitide concentration in the blood.


Eligibility criteria:
inclusion criteria: * is hospitalized with congestive heart failure (chf) * has a swan-ganz catheter inserted for chf management and has pulmonary capillary wedge pressure 18 mmhg or higher exclusion criteria: * has had a heart transplant * requires mechanical ventilation or mechanical circulatory support

Keywords: carperitide atrial natriuretic peptide treatment efficacy safety heart failure, congestive pulmonary artery catheterization
celiac disease prevention

Conditions: Celiac Disease

Summary: celiac disease is an autoimmune disease induced by wheat gluten. destruction of epithelial cells and microvilli on gut mucosa is causing a "flat mucosa" and an absorption defect. the diagnosis is based on typical microscopical finding in biopsy specimens but serum antibodies to tissue transglutaminase and certain gliadin peptides are strongly associated with the pathology. severe diarrhoea associated with growth disturbance in infancy was historically characterising the disease but is nowadays rare. clinically more mild forms including silent disease are very common. studies based on antibody screening and biopsies done in autoantibody positive subjects have confirmed a frequency of about 1-2% in adult population. undiagnosed disease is associated with deficiencies of nutrients and vitamins leading to various chronic symptoms like anaemia, osteoporosis and general fatigue. it has also been recently found that undiagnosed celiac disease may be associated with general underachievement in society probably associated with common psychological symptoms like fatigue and depression during the adolescence. the disease is treated by complete elimination of wheat, rye and barley in the diet, which is laborious and causing considerable extra costs in nutrition. much progress has been recently made in understanding of the genetic background and immune markers associated with the disease as well as in understanding those patterns of gluten introduction in infancy, which might be connected to a high disease risk. our aim in this study is in the first phase to identify children at high genetic risk (around 10%) and in a follow-up study to define: 1. are the age, dose of gluten and presence of simultaneous breast feeding at the introduction of gluten associated with the risk of celiac disease? 2. is it possible to decrease the frequency of celiac disease by nutritional counselling? 3. is it possible to predict development of celiac disease by immunological tests before the development of mucosal lesion if we can confirm, that optimising the conditions at the introduction of wheat gluten in infancy diet significantly reduces the disease incidence, will this have an important effect on the nutritional recommendations concerning the diet in infancy. combining genetic screening and immunological tests might also offer a way to reduce the frequency of celiac disease and help in early diagnosis and organisation of an adequate treatment


Eligibility criteria:
inclusion criteria: * presence of hla-risk alleles dqa1\*05 and dqb1\*02 exclusion criteria: * lack of these hla risk alleles

Keywords: celiac disease genetic risk gluten introduction predicting antibodies
therapeutic thoracentesis for patients with congestive heart failure and large pleural effusion

Conditions: Congestive Heart Failure; Transudative Pleural Effusion

Summary: transudative pleural effusions are a common manifestation of patients with congestive heart failure. severe dyspnea and respiratory failure may develop in those with large effusions, which in general show poor response to medical treatment. therapeutic thoracenteses (tt) may be indicated in these patients and can produce marked relief of symptoms. however, the underlying effect of tt on gas exchange and respiratory mechanics in theses patients remains unclear. the researchers' hypothesis is that,tt may improve arterial oxygenation and respiratory mechanics in patients with congestive heart failure complicated by large pleural effusions.


Eligibility criteria:
inclusion criteria: * transudative pleural effusion established by the criteria of light * the effusion occupying at least half of one hemithorax shown on chest radiography * symptoms of respiratory distress * diagnosis of congestive heart failure exclusion criteria: * severe uncontrolled coagulopathy * unstable hemodynamics * diagnosis of liver cirrhosis, chronic obstructive pulmonary disease,asthma and/or any parenchymal lung disease, such as pneumonia, fibrosis or malignancy.

Keywords: congestive heart failure thoracentesis transudative pleural effusions
lung scintigraphy for pulmonary embolism diagnosis in covid-19 patients.

Conditions: Pulmonary Embolism; COVID-19

Summary: a frequent complication of covid-19 disease is pulmonary embolism (pe). lung ventilation/perfusion (v/p) scintigraphy is a well-established test for pe diagnosis. the test is interpreted based on the recognition of wedge shaped perfusion mismatched defects. however, the ventilation procedure increases the potential risk of contamination by the aerosol secretion and the expired air. a variety of strategies have been proposed in the nuclear medicine literature regarding performance of lung ventilation scintigraphy in covid-19 patients with suspected acute pe. however, there is currently no factual data in this specific population to support recommendations to the nuclear medicine community. the aim of this study was to assess the role of ventilation imaging when performing lung scintigraphy for suspected pe in covid-19 patients.


Eligibility criteria:
inclusion criteria: * patients with suspected covid-19 disease * referred for lung scintigraphy for suspected acute pe exclusion criteria: * patient under guardianship or curatorship * patient deprived of liberty by an administrative or judicial decision * inability or refuse to give consent

Keywords: lung scintigraphy
effectiveness of mbsr among teachers at upper secondary schools and schools of health and social care

Conditions: Stress Reduction; Mental Well-being

Summary: the aim is to evaluate the effectiveness of online mindfulness-based stress reduction among school teachers in danish upper secondary schools and schools of health and social care on mental well-being in the teachers and their students. the study is a cluster-randomised trial including 43 schools; 76 teachers; 1.000 students.


Eligibility criteria:
inclusion criteria: * school teacher at a danish upper secondary school or school of health and social care that commit to participate in a trial aiming to implement and evaluate the effectiveness of a school-based mindfulness programme. exclusion criteria: * acute treatment-demanding clinical depression or a diagnosis of psychosis or schizophrenia * abuse of alcohol, drugs, medicine
tace combined with synchronous radiofrequency /microwave ablation to treat large and huge hepatocellular carcinoma

Conditions: Carcinoma, Hepatocellular

Summary: it is a prospective and multi-center clinical research in china to compare the efficacy, safety and related impact factors between tace alone and tace combined with synchronous multi-point mwa/rfa for large and huge liver cancer.

it is an open random prospective phase iii clinical trial conducted by principal investigator professor jian-hua wang. investigators in twenty-five hospitals in china participate in. patients with unresectable large hcc (\>5cm in diameter) and huge hcc (\>=10cm in diameter) are enrolled. the investigators propose to recruitment 280 patients who are randomly assigned into the combined group (treated with tace and synchronous ablation) and the control group (treated with tace alone) according to the proportion of 1:1, which means 140 patients in each group. the criteria of inclusion and exclusion, and the methods of lab tests, imaging modality and treatment procedures are the same.

Eligibility criteria:
inclusion criteria: 1. patients with primary liver cancer aged from 18-80 years, and life expectancy longer than three months; 2. patients with large hcc (\>5cm in diameter) and huge hcc (≥10cm in diameter), including hcc and mixed type of liver cancer (hcc-icc); 3. patients with no thrombus in main portal vein (pv) 4. patients' liver function classified as child-pugh a or b, ecog ps ≤ 2; 5. patients without bleeding tendency or coagulation disorder, or with reversible coagulopathy after therapy; 6. white blood cell count ≥ 3.0×10\^9/l; 7. hemoglobin ≥ 8.5g/dl; 8. platelet ≥ 50×10\^9/l; 9. inr ≤ 2.3 or pt not exceeding the upper limit of reference 3 seconds; 10. blood creatinine less than 1.5 times of upper limit of reference; 11. patients and/or their relatives willing to join in the clinical trial and signing the informed consent. exclusion criteria: 1. patients with diffuse type of liver cancer; 2. cholangiocellular carcinoma 3. patients with main pv thrombus; 4. patients with hepatic vein thrombus; 5. patients with lymph node or distant metastasis outside of liver; 6. patients' liver function classified as child-pugh c and no improvement after treatment of liver protection; 7. patients with irreversible coagulation disorder and abnormality in blood routine test, or having obvious bleeding tendency; 8. patients with intractable massive ascites; 9. patients' ecog ps \>2; 10. patients complicated with active infection, especially cholangitis; 11. patients with severe disorders of heart, lungs, kidneys, or brain; 12. patients and/or their relatives refuse to anticipate this study.

Keywords: hcc tace thermal ablation safety/efficacy
a randomized trial on platelet rich plasma versus saline dressing of diabetic foot ulcers

Conditions: Diabetic Foot

Summary: new treatments for persistent dfu have emerged, among which are the bioengineered skin substitutes, extracellular matrix proteins products, matrix metalloproteinases modulators, and growth factor therapy. platelet rich plasma (prp) gel has been used for stimulating wound healing since the last decade of the 20th century. this randomized trial was conducted to assess the role of prp in gel form as a treatment for clean non-healing diabetic foot ulcer in comparison to regular dressing with saline as a control.


Eligibility criteria:
inclusion criteria: * adult patients of both sexes aging below 70 years with non-infected chronic foot ulcer confined to one anatomical site. chronicity was defined as non-healing ulcer for twelve or more weeks exclusion criteria: * patients with chronic limb ischemia. * evidence of osteomyelitis in the affected foot * exposed tendons, ligaments or bones at the base of ulcer * patients who received radiotherapy or chemotherapy at time of study or within 3 months of its beginning. * patients having low peripheral platelet count, low serum albumin level or low hemoglobin level
effect of addition of mannitol to bupivacaine on ianb success and post-endodontic pain

Conditions: Irreversible Pulpitis

Summary: inferior alveolar nerve block using either 0.5% bupivacaine alone or in addittion to mannitol in patients with irreversible pulpitis in mandibular molars.

patients with irreversible pulpitis in mandibular molars will be selected according to the eligibility criteria and patients are then randomized to either using 0.5% bupivacaine alone or in addition to mannitol. anesthetic success and postoperative pain will then be assessed.

Eligibility criteria:
inclusion criteria: 1. adult patients; age between 17-35 years old. 2. males or females. 3. medically-free patients 4. patients suffering from symptomatic irreversible pulpitis without apical periodontitis in mandibular molar teeth. 5. positive patients' acceptance for participation in the study. exclusion criteria: * patients who had any analgesic during proceeding 12 hours before the treatment. * teeth with necrotic, infected pulp, swelling or symptomatic apical periodontitis (apical abscess). * pregnant females. * patients with history of significant medical conditions (contraindication of mannitol use). * addiction * psycological disturbance.

Keywords: inferior alveolar nerve block long-acting local anesthesia bupivacaine mannitol symptomatic irreversible pulpitits
study of lx6171 in elderly volunteers with age associated memory impairment

Conditions: Age-Related Memory Disorders

Summary: the purpose of the study is to determine the safety, tolerability, and effectiveness of 2 dose levels of lx6171 given over 28 days in patients with age associated memory impairment (aami).


Eligibility criteria:
inclusion criteria: * males and females aged 60-80 years old. * complaints of memory loss in everyday life * non-smokers or very light smokers (no more than 10 cigarettes/day) * negative urine screen for drugs of abuse * ability to provide written informed consent exclusion criteria: * history or evidence of any disease, disorder or injury that could cause cognitive deterioration. * need for medications other than hormone replacement therapy, daily vitamins, or over-the-counter pain killers * clinically significant abnormality on electrocardiogram * history of alcoholism or drug dependence * use of dietary supplements containing huperzine a, gingko biloba, phosphatidylserine, or docosahexaenoic acid (dha)
confocal endomicroscopy of pancreatic invivo

Conditions: Pancreatic Cysts

Summary: confocal laser endomicroscopy (cle) is a novel and highly promising imaging method for that allows in vivo imaging of the mucosal layer at resolution of approximately 1 micron. cellular and sub-cellular structures as well as capillaries and single red blood cells can be visualized. cle is now well established as a highly accurate method for distinguishing neoplasia in the gastrointestinal tract lumen via endoscopy. a major new breakthrough is the development of sub-millimeter cle probes that can be passed via an image guided needle (ncle) into solid organs and cysts. it is hypothesized that ncle will help distinguish the benign, premalignant and malignant cystic lesions of pancreas by visualizing the cellular lining of the cysts, thereby, avoiding unnecessary surgery in patient with benign cysts and guiding to early and effective surgical removal of high risk neoplastic lesions. a prototype minimal risk ncle system has been developed that can be passed via standard endoscopic ultrasound needles into the pancreas but fda clearance for in vivo use is not expected until late 2010. the investigators propose to evaluate this prototype ncle system in vivo during endoscopic ultrasound (eus), as an initial pilot study.

hypothesis: the confocal laser endomicroscopy imaging of the ncle can differentiate between non-mucinous, mucinous non- malignant and malignant pancreatic cysts in vivo and has increased sensitivity compared to endoscopic ultrasound-fine needle aspiration (eus-fna) tissue sampling. in this pilot study the investigators will primarily evaluate technical feasibility and interobserver agreement. 1. in patients undergoing eus for suspected pancreatic cysts, the investigators will evaluate the key ncle image features of non mucinous, mucinous, and malignant pancreatic cystic neoplasms (pcn). 2. the investigators will estimate the initial image quality, feasibility, and interobserver agreement of ncle 3. the investigators will establish the preliminary accuracy of ncle to be used for planning a larger comparative trial

Eligibility criteria:
inclusion criteria: * patients undergoing endoscopic ultrasound for evaluation of pancreatic cysts (including pseudocysts and suspected pancreatic cystic neoplasms) in the gastrointestinal (gi) lab at mayo clinic jacksonville. exclusion criteria: * unwilling/unable to consent; * solid pancreatic mass on computerized axial tomography/magnetic resonance (ct/mr); * allergy to fluorescein; * pregnancy.

Keywords: pancreatic cysts
prevent diabetic kidney disease among egyptians

Conditions: Diabetes Mellitus Without Complication

Summary: study of the possibility to prevent the development of diabetic kidney disease in type 2 diabetic patients

study of the possible role of the sglt2 inhibitors to prevent the development of frank type2 dm among prediabetic candidates. study of the possible role of the sglt2 inhibitors to prevent the development of diabetic complications, namely diabetic kidney disease, diabetic retinopathy and neuropathy.

Eligibility criteria:
inclusion criteria: * diabetics,prediabetics exclusion criteria: -
efficacy of dietary supplementation and physical activity in sarcopenic elderly

Conditions: Sarcopenia

Summary: this 3 months randomized, double-blind, placebo-controlled supplementation trial tested the hypothesis that nutritional supplementation with whey protein, essential amino acids and vitamin d concurrent with regular, controlled physical activity would increase muscle mass, strength, physical functional, quality of life, and decrease the risk of malnutrition and inflammation in sarcopenic elderly.

this 3 months randomized, double-blind, placebo-controlled supplementation trial tested the hypothesis that nutritional supplementation (32 g) with whey protein, essential amino acids and vitamin d concurrent with regular, controlled physical activity would increase muscle mass (assessed by dxa), strength (assessed by handgrip dynamometer), physical functional (assessed by adl), quality of life (assessed by sf-36), and decrease the risk of malnutrition (assessed by mna and igf-i) and inflammation (assessed by c-reactive protein) in sarcopenic elderly.

Eligibility criteria:
inclusion criteria: * eligible patients were aged 65 years or older with appendicular skeletal muscle mass/height2 2sd below mean of young adults (baumgartner r, 1998), so with relative muscle mass \< 7.26 kg/m2 for men and \< 5.5 kg/m2 for women. * patients were not affected by acute illness, severe liver, heart or kidney dysfunction, and had a body weight which had been stable for 6 months exclusion criteria: * subjects with altered glycometabolic control, disthyroidism and other endocrinopathies and cancers, as well as patients treated with steroids and heparin, or with total walking incapacity were excluded.
php home preferential hyperacuity perimeter for the detection of choroidal neovascularization (cnv)

Conditions: Age Related Macular Degeneration

Summary: the primary objective of this study is to assess the ability of the php \& hphp to detect newly diagnosed non treated chorodial neovascularization (cnv) lesion associate with advanced age related macular degeneration (amd) and differentiate them from early/intermediate/ga amd

the study is prospective, multi-center, comparative the php is a class i fda approved device ( k050350 )

Eligibility criteria:
inclusion criteria: * patients with amd related lesions: newly diagnosed (up to 6 months) non-treated cnv patients secondary to amd in the study eye, or ga patients or early and intermediate amd patients. * age ³ 50 for amd patients * va with habitual correction in study eye 6/60 or better * mental and physical ability to perform a php/hphp test * subject able and willing to sign consent form and participate in study * subject is not participating in another study when conducting the test exclusion criteria: * evidence of macular disease other than amd or glaucoma in the study eye. * presence of any significant media opacity that precludes a clear view of the macular area as identified by biomicroscopy, fundus photography, or fluorescein angiography in the study eye * any non-macular related ocular surgery performed within 3 months prior to the study in the study eye * cnv patient inability to tolerate intravenous fluorescein angiography

Keywords: amd cnv php
hypofractionated radiotherapy followed by surgical resection in the treatment of soft tissue sarcomas

Conditions: Soft Tissue Sarcomas

Summary: the trial will use neoadjuvant hypofractionated radiotherapy followed by surgical resection in the treatment for soft tissue sarcoma. it will allow patients to be treated over a shorter course (5 or 15 days of radiation) compared to the traditional 5 week regimen. it is proposed that this will be possible without increasing the risk of wound complication or local recurrence compared with a traditional 5 week course of pre-operative radiation.

study objectives: primary: * to investigate the efficacy of neoadjuvant hypo-fractionated radiotherapy (hrt) followed by surgical resection in the treatment of soft tissue sarcoma (sts) as measured by local control * examine the side effect profile using radiation therapy oncology group (rtog) and common terminology criteria for adverse events (ctcae) acute and late side effects criteria and major and minor post-operative complication rates. outline: patients are assigned to 1 of 2 groups by the radiation oncologist. group i (ultra-hypofractionation \[uh\]): patients undergo hrt daily for a total of 5 fractions followed by surgery. group ii (moderate hypofractionation \[mh\]): patients undergo hrt daily for a total of 15 fractions followed by surgery. after completion of study treatment, patients are followed up within 3 months, then every 3-6 months for a minimum of 2 years.

Eligibility criteria:
inclusion criteria: * histologic diagnosis of a soft tissue sarcoma of extremity, pelvis, chest wall or trunk/abdominal wall (non-retroperitoneal location) * ecog performance status 0-2 * patient must be deemed able to comply with radiation treatment and surgery exclusion criteria: * history of prior radiation to the same area to be irradiated * pregnancy * active collagen vascular disease or patients genetically predisposed to increased radiation related side effects

Keywords: hypofractionated radiotherapy