Kornimate/medical-research-clean huggingface dataset:
clinical evaluation of an apnea index for diagnosis and screening of obstructive sleep apnea (osa)

Conditions: Obstructive Sleep Apnea

Summary: the study is designed to compare the apnea event recognition capability of the capnostream 20 with investigational software to polysomnograph recordings scored by a trained analyst. the study will compare the apnea index score (ai) calculated by the capnostream 20 algorithm based on capnography to that calculated by a trained analyst evaluating polysomnograph recordings. to this aim, subjects will be connected to embla n7000 polysomnograph, and to the capnostream 20, in order to monitor co2 and spo2 during routine overnight sleep studies. the capnostream, using both its usb data port and analog output port will simultaneously provide the monitored data both to a usb flash memory device and polysomnograph for storage for future analysis. the data collected by the polysomnograph including the capnostream data will be analyzed by a trained expert for evaluation of apnea events obtained from both sources. in parallel, the capnostream data as collected with the usb flash memory, will be downloaded onto a pc, and using the oridion software algorithm designed for evaluating the data (to be implemented in the monitor when validated), the apnea index and oxygen desaturation index will be calculated. the results of the apnea index scores calculated from the polysomnograph and from the dut will be compared. based on the results, the study will then evaluate the ability of the capnograph/pulse-oximeter as a tool for screening and assisting in the diagnosis of patients with obstructive sleep-apnea in the hospital environment, where it is being used as a ventilation monitor based on the demonstration of a high correlation with the gold standard in the sleep lab.

the clinical investigation will be conducted until enrollment of at least 30 adult and 30 pediatric patients of both sexes with complete data sets are collected from three different sleep lab sites per the fda guidance requirements. the enrollment time will last up to six (6) months. the overall number of enrolled patients (i.e. with complete/incomplete data) will not exceed 80 patients.

Eligibility criteria:
inclusion criteria: * all adults \> 18 years old and able to understand and give consent per the irb or a child above one years old consented by a parent or legal guardians. * patients consented or for whom legal guardians consented for the participation of this trial. * patient recommended for a sleep assessment by medical staff. exclusion criteria: * patients who in the opinion of the investigator should not participate.

Keywords: sleep studies sleep apnea osa referred for sleep studies by a medical professional
acute-to-chronic glycemic ratio (acgr) is a marker of dfus .

Conditions: Diabetic Foot Ulcer (DFU)

Summary: diabetic foot ulcers (dfus) have resulted from peripheral arterial ischemia and peripheral neuropathy that are complicated with infections and amputation of the lower extremities. uncontrolled glycemic status and significantly higher glycosylated hemoglobin (hba1c) are associated with dfus. this study aimed to assess the acute-to-chronic glycemic ratio (acgr) in type 2 diabetes (t2d) with dfus and compare it with those without dfus, considering the relationships of this ratio with other indices that characterized the pathogenesis of t2d. this cross-sectional study was conducted on t2d with dfus and non-dfus. the primary outcome is acgr. the secondary outcomes are indices related to the anthropometric, metabolic, and hematological variables.

dfus are a macrovascular complication of diabetes mellitus resulting from peripheral artery disease and peripheral neuropathy that commonly affects the lower extremities. the dfus are usually classified and scored according to the clinical findings. the acgr is computed by dividing the acute (or current, or on admission in hospital) plasma glucose level by the chronic plasma glucose level calculated using the current (or on admission) hba1c value.

Eligibility criteria:
inclusion criteria: type 2 diabetes clinical and laboratory diagnosis of diabetic foot ulcers treatment with oral anti-diabetes +/- insulin exclusion criteria: history of recent systemic infections alcohol consumption surgical procedures within 4 weeks pregnant or breast-feeding women; terminal illnesses. -

Keywords: diabetes foot ulcers acute-to-chronic glycemic index leucocyte-glucose index triglyceride-glucose index
induced adult refractory active crohn's disease clinical relieving by using thalidomide

Conditions: Crohn Disease

Summary: with the development and application of biological agents, the treatment effect was considerable degree improvement on refractory corn's disease. however, there are quite a part of the cd patients lost response during treatment of using response. moreover, due to various reasons, there still a lot limited on the using of biological agents in china, that make quite a part of the refractory cd patients lack of further medical treatment options. there has been a rct study which prove that thalidomide effect and safety on treating refractory cd or who were lost response by using biological agents in italy, but the object of study is only limited in children and adolescents. there are some small sample studies also confirmed the efficacy and safety on refractory corn's disease by using thalidomide, but need more rct evidence.

it will be divided two groups of patients by using randomized, double-blind. one group was treated by thalidomide, the other was placebo. it will be unlocked blind and analysis the effect and safety about thalidomide after 8 weeks. the second, patients still use thalidomide after unlock blind to prove its longtime treatment effect and safety.

Eligibility criteria:
inclusion criteria: * age 18-50 years old * diagnosis of patients with cd * disease in the activity: cda ⅰ \> 150 points, endoscopic see active lesions * refractory: immunosuppressive drugs or biological agents which are used in current treatment is invalid and/or intolerance exclusion criteria: * fiber stenosis caused by gastrointestinal obstruction symptoms * fistula exclude anal fistula * pregnancy or lactation * period of women have fertility program during the study * treatment not foot eight weeks after last ifx * central or peripheral nerve disease * abnormal in liver and renal function * heart function failure * malignant tumor * active tuberculosis
characterization of manual dexterity by finger force manipuladum (ffm) in patients with writer's cramp and in control subjects

Conditions: Dystonic Disorder; Focal Dystonia; Writer's Cramp

Summary: writer's cramp is a focal dystonia characterized by abnormal movements and postures during writing. limited finger independence during writing manifests as difficulty suppressing unwanted activations of neighbouring non task-relevant fingers. patients with writer's cramp also have difficulty in fine control of grip force. the investigators have recently developed the finger force manipulandum which quantifies the forces applied by each fingers in different tasks. this method is sensitive for detection and quantification of small unwanted contractions in non-active ('stationary') fingers. different tasks have been developed to assess abilities such as finger individuation but also fine finger force control, finger movement regularity and speed. the aim of this study is to assess if developed tasks allow to precisely characterize writer's cramp condition in terms of abilities aforementioned. to do so, performance of 20 writer's cramp patients in the developed task will be compared with performance of 20 control participants (matched in age, sex and writing hand) in the same tasks.


Eligibility criteria:
inclusion criteria for patients with writer's cramp * patient with writer's cramp and writing speed \<140 letters / min * writer's cramp focal dystonia specific to the task of writing * patient treated or not with botulinum toxin injection * person having attended school in french non inclusion criteria for patients with writer's cramp * patients whose writer's cramp has no impact on the handwriting and has kept a writing speed\> 140 letters per minute. * tremor of writing * neurological condition other than writer's cramp (eg parkinson's syndrome) * pain, trauma or pathology of the upper limb of the writing member other than the writer's cramp who required medical or surgical treatment in the last 6 months preceding the initial check-up inclusion criteria for control subjects •\> 18 years old * without writer's cramp * person having attended school in french non inclusion criteria for control subjects * tremor of writing * neurological condition other than writer's cramp (eg parkinson's syndrome) * pain, trauma or pathology of the upper limb of the writing member other than the writer's cramp who required medical or surgical treatment in the last 6 months preceding the initial check-up matching criteria between cases and control patients * age (± 5 years) * gender * hand writing

Keywords: dystonic disorder focal dystonia writer's cramp
pascal vs. mitralclip for mitral valve transchatheter edge-to-edge repair

Conditions: Mitral Regurgitation; Functional Mitral Regurgitation; Degenerative Mitral Valve Regurgitation

Summary: comparsion of the current two available teer systems, the mitraclip with the pascal repair system in terms of their effectiveness and safety in patients with degenerative mitral regurgitation (dmr) and in patients with functional regurgitation (fmr), who were referred for an interventional therapy by the heart team due to a high surgical risk profile.

a prospective single-center, open-label study to evaluate the safety and effectiveness of transcatheter mitral valve repair of the mitral valve (m-teer) using the edwards pascal transcatheter valve repair system compared to using the abbott mitraclip in patients with severe and symptomatic degenerative or functional mitral regurgitation (fmr). the type of device system used was not randomized but was determined by the operational structuring of our mitral valve program such that patients were scheduled for the next available implantation date with weekly alternating time slots for mitraclip device and pascal device. treating physicians had no influence on scheduling or system selection. follow-up examinations will be performed one month and one year after the procedure with assessment of echocardiographic and functional status based on the new york heart association (nyha) grade. patient characteristics, baseline data, and data related to the procedure were assessed using a registry, medical records and the procedure protocols. this study is a subproject of the mitraclip® registry (nct02033811)

Eligibility criteria:
inclusion criteria: * age ≥18 years * severe mitral regurgitation (3+ to 4+) * symptom status: nyha functional class ≥ ii * patients with fmr or dmr, who were referred for m-teer by the heart team decision due to a high exclusion criteria: * life expectancy \< 1 year * anatomy of the mitral valve that may not be suitable for the mitraclip or pascal device * contraindication for transoesophageal echocardiography * active endocarditis * pregnant or planning pregnancy within next 12 months

Keywords: mitral regurgitation functional mitral regurgitation degenerative mitral valve regurgitation m-teer teer
sensory stimulation effect on movement speed in patients with parkinson disease

Conditions: Parkinson Disease

Summary: movement slowness (bradykinesia) is one of the main motor symptoms in parkinson disease (pd). several studies have shown that patients with pd exhibit slowness because they are unable to modulate, in an optimal way, the velocity of voluntary motor acts not induced by external stimulation. indeed, these patients have difficulties to integrate multi-sensorial information, mainly proprioception. the investigators investigated changes in shoulder velocity during pointing movements by patients with pd after stimulation of soft tissues (aponeurosis) of upper limb muscles. the stimulation consisted of manipulating, with a hook (the diacutaneous fibrolysis method), the aponeurotic tissues enrobing the heads of the upper limb muscles. this technique has previously been shown to decrease passive tension and the tendon reflex response of the manipulated muscle group. the investigators hypothesis is that aponeurotic manipulation of shoulder muscles therefore creates a modification in the proprioceptive information, which in return temporarily decreases the bradykinesia of shoulder movements.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of parkinson disease exclusion criteria: * patients with a limitation in the shoulder range of motion necessary to perform pointing movements

Keywords: parkinson disease sensory stimulation bradykinesia
efficacy of dental hygiene aids in reducing gingival bleeding and plaque among orthodontic patients.

Conditions: Gingival Bleeding; Dental Plaque

Summary: adult orthodontic patients aged 18-30 were included in a randomised, single-blind clinical research using a split-mouth design at a dental clinic. both the waterpik® and the super-floss® water flossers are manufactured by oral-b.

in order to reduce gingival inflammation and remove subgingival plaque, oral hygiene therapy is necessary. the available evidence indicates that mechanical plaque control, which patients administer themselves daily, is the most important factor in managing and reducing plaque accumulation. aim: this research aimed to determine whether waterpik or superfloss was more effective in lowering the gingival bleeding score and plaque. methods: adult orthodontic patients aged 18-30 were included in a randomised, single-blind clinical research using a split-mouth design at a dental clinic. both the waterpik® and the super-floss® water flossers are manufactured by oral-b.

Eligibility criteria:
inclusion criteria: * participants aged 18-35 years undergoing orthodontic treatment and * systemically healthy without habits exclusion criteria: * participants not undergoing orthodontic treatment and participants undergoing orthodontic treatment in the included age category but with systemic conditions prevalent * missing teeth and * treated previously for periodontal conditions

Keywords: dental plaque gingival bleeding oral irrigator waterpik super floss
eye movement behaviour and pupil size in natural outdoor and indoor scenes

Conditions: Light Sensitivity

Summary: in this study, the researchers will be using eye tracking and detailed lighting measurements to understand how different types of indoor and outdoor lighting affect the eye movements and pupil sizes of our participants. participants will be paired up and undergo six eye tracking sessions, split across two appointments. each appointment will involve viewing either indoor or outdoor scenes, and before each session, participants will spend time adapting to the lighting conditions. overall, each participant will spend 24 minutes being tracked, and the entire study will take about 2-3 hours to complete. the investigators expect differences in eye movements and pupil size between indoor and outdoor scenes.


Eligibility criteria:
inclusion criteria: * no previous eye-surgeries or ocular impairments like anisometropia, amblyopia, strabism, cataract, watery eyes or hanging eye lids * normal or corrected-to-normal visual acuity (+3dpt. to -5dpt.) * normal colour vision * normal binocular vision exclusion criteria: * any use of medications or drugs that influence photosensitivity or the ability to concentrate * excessive alcohol and/or drug use * presence of psychiatric disorders * poor sleep quality * diagnosed with epilepsy
effect of night float call on sleep and activity patterns among anesthesia residents

Conditions: Sleep Disorder, Shift Work; Fatigue; Sleep Disturbance

Summary: with increasing awareness about physician fatigue and its effect on patient safety, residency programs are increasingly transitioning to a night float call system. in other industries, multiple night shifts in a row can cause a disruption in the circadian rhythm, sleep debt, shift work disorder, that is related to chronic medical conditions such as obesity and cardiovascular disease. we will evaluate the effect of different call structures on resident activity, sleep and self reported measures of wellness using a commercially available fitbit device.

participants will be recruited via an email once they are scheduled for a week of night float in the stanford main operating room or on their obstetric anesthesia rotation. potential participants who are taking prescription medications that might affect their alertness during the study period will not be enrolled. the investigators will quantify the changes in sleep pattern and activity during different call rotations. self reported aspects of well being including fatigue, physical function, and positive affect will be assessed with nih promis surveys periodically during the study period. the investigators will use the fitbit alta hr data to quantify the change in total amount of sleep, sleep interruption and sleep phase and steps per day. data will be analyzed only when it is coincident with heart rate data to correct for periods when the device is not used. activity will not alter from the participants normal except that they will wear the fitbit and respond to the nih promis surveys over the study period. data from nih promis surveys, fitbit and provided demographic information including age, sex and bmi, and number of previous night float periods previously completed. after association, data will be completely de-identified. all data will be normalized to the participant's baseline value during the run-in week. the call week and post call week will be analyzed with a time series mixed effects model using r and/or nonmem (a program for nonlinear mixed effects modeling). the effects of the above demographic variables will be assessed as potential covariates. the investigators anticipate that this observational study will be the first of many studies looking at the effects of changing sleep patterns on activity and well-being

Eligibility criteria:
inclusion criteria: * all residents (pgy2-5) who have been scheduled for either general operating room night float call or obstetric anesthesia rotation exclusion criteria: * participants who report taking prescription medications that may effect alertness during the study period will not be enrolled.

Keywords: medical education physician well-being internship and residency work schedule tolerance fatigue physician burnout sleep disruption
correlation bis scores mentally retarded patients

Conditions: Mental Retardation

Summary: the bis monitor is a tool which assists anesthesiologists in monitoring the depth of anesthesia or level of anesthesia. the study doctors would like to see if it is useful tool for patients who are mentally challenged and require anesthesia.

general endotracheal tube anesthesia (geta) is administered for mentally retarded patients that need dental rehabilitation. geta is done, in all patients, with routine monitoring of electrocardiography, blood pressure recording, pulse oximetry and end-tidal capnography. these measurements are also used indirectly to determine the depth of anesthesia and the anesthetic is titrated to prevent awareness during surgery and any subsequent recall (1). in addition, a recently introduced functional electroencephalography (eeg)-based awareness monitor directly analyzes the brain wave pattern during anesthetic delivery and aids the anesthesiologist in maintaining the ideal depth of anesthesia. the eeg based monitor serves to prevent awareness and recall due to light anesthesia or prolonged recovery following deep anesthesia (2). this instrument, named the bispectral index scale (bis) monitor, is non-invasive and is approved by the food \& drug administration. however, the bis monitor is not being used routinely during the anesthetic management of mentally retarded patients due to a belief that such monitoring would be inaccurate in this cohort of patients (3). this assumption lacks scientific validation. our trial will investigate the usefulness of bis monitoring in mentally retarded patients and document any correlation between the severity of mental retardation and bis scoring during various phases of anesthesia, such as awake status and sedation prior to anesthesia, induction and maintenance of anesthesia, and emergence and recovery from anesthesia. the anesthetic protocol will be standardized and the anesthetic management will not deviate from routine practice. the adjuvant therapies for infection prophylaxis and pain control will be administered in the usual fashion.

Eligibility criteria:
inclusion criteria: * mentally retarded persons ages 12 to 65 undergoing dental rehabilitation exclusion criteria: * patients who are pregnant parents/and or legal guardians who do not wish to give consent

Keywords: general anesthesia dental rehabilitation mental retardation
meta-iodobenzylguanidine (123i-mibg) scintigraphy imaging in patients with heart failure and control subjects without cardiovascular disease

Conditions: Heart Failure, Congestive

Summary: the study is designed to study the utility of 123i-mibg as a diagnostic imaging agent to predict cardiac outcome in subjects with heart failure and in comparison to subjects without cardiovascular disease.


Eligibility criteria:
inclusion criteria: * study subjects must be adults with an established diagnosis of heart failure (new york heart association class ii or iii) and reduced left ventricular ejection fraction (lvef) (≤ 35%) or be healthy volunteers without heart disease. exclusion criteria: * healthy volunteers were not eligible if they had a history of diabetes mellitus, signs/symptoms of neurological disease (e.g., parkinson's disease, multiple system atrophy, parkinsonian syndromes), or other diseases known to affect the sympathetic nervous system. * subjects with new york heart association class i or iv heart failure were not eligible. * subjects were excluded if they had previously received 123i-mibg or 131i-mibg or participated in a clinical study involving investigational medicinal product or devices within 30 days. * subjects that had a pacemaker or had received defibrillation, anti-tachycardia pacing or cardioversion to treat a previous arrhythmic event or had an icd inserted within 30 days before study entry are not eligible.

Keywords: heart failure nuclear cardiology sympathetic innervation 123i-mibg
the evaluation of a mask for the treatment of obstructive sleep apnea

Conditions: Obstructive Sleep Apnea

Summary: this investigation is a prospective, non randomized, non blinded study. this investigation is designed to evaluate the performance, comfort and ease of use with the f\&p trial full face and nasal mask amongst obstructive sleep apnea (osa) patients. up to 70 osa patients will be recruited from the north texas lung and sleep clinic (ntlsc) database

visit 1 will involve the participants being fitted with the f\&p trial full face or nasal mask for use in-home. the participant will then come in to return the mask (visit two) and have a final interview, this ensures the maximum time participants will be exposed to the trial mask in home will be 14 ± 4 days from visit one. the mask will be returned to the institution at the conclusion of the trial and the participant will return to their previous mask. the institution will recruit all patients within three weeks of the beginning of the study.

Eligibility criteria:
inclusion criteria: * adult (22+ years of age) * able to give informed consent * apnea hypopnea index (ahi) ≥ 5 on diagnostic night * either prescribed automatic positive airway pressure (apap), continuous positive airway pressure (cpap) or bi-level positive airway pressure (pap) for osa * fluent in spoken and written english * existing oronasal and nasal mask user exclusion criteria: * inability to give informed consent * participant intolerant to pap * anatomical or physiological conditions making pap therapy inappropriate * current diagnosis of respiratory disease or carbon dioxide (co2) retention * pregnant or may think they are pregnant.