Kornimate/medical-research-clean huggingface dataset:
a study to learn about the effects of medicines that help in thinning the blood in people with atrial fibrillation (af) between 2016 and 2020 in france

Conditions: Atrial Fibrillation

Summary: the purpose of this study is to look at how many patients with af had strokes, major bleeding and death in both people who had and had not taken any oral anticoagulant. atrial fibrillation (af) is an irregular and often very rapid heart rhythm (arrhythmia) that can lead to blood clots in the heart. this increases the risk of stroke. anticoagulants are medicines, also called blood thinners, which help prevent blood clots from forming or getting bigger. this study includes patient's data from the database who: * had at least one hospital stay with af * are new users of oacs for af treatment * are 18 years and older when they were confirmed to have af all the patient's data included in this study would have either received the oac therapy or not. this study aims to look at any events of strokes, major bleeding and death. the data of patients will be collected from the french national health insurance claims database (snds). the planned study period is thought to be from 1st january 2016 till 31st december 2020


Eligibility criteria:
inclusion criteria: * identified patients with af aged 18 years and older at diagnosis of af exclusion criteria: * af patients with at least one hospital stays for associated valve disease or valve surgery * patients treated with an oac for another indication than af
mindful kala: virtual bharatanatyam wellness program for students

Conditions: Quality of Life; Cultural Competence; Stress

Summary: in the current study, the researchers propose to develop and pilot test a bharatanatyam (i.e. indian classical dance) program called mindful kala with the hopes of decreasing stress and increasing psychosocial well-being, mindfulness, cultural competence, and connectedness amongst a group of college students. the investigators hope that this program can help students cultivate well-being during the challenging and stressful time of covid-19.

objectives: 1. evaluate the effects of the mindful kala program on outcomes of health-related measures such as mindfulness, stress, connectedness, and wellbeing amongst students. the investigators hypothesize that participants will experience fewer symptoms of stress, increased mindfulness, increased well-being, and increased connectedness. 2. evaluate the effects of the mindful kala program on changes in measures of cultural competence. the investigators hypothesize that the level of cultural competence will increase among the students. 3. develop and examine the feasibility and acceptability of a 4-week mindful kala program for college students.

Eligibility criteria:
inclusion criteria: * yale student * 18 years of age or older * must complete all survey measures * is available for all of the designated session one \& session two dates and times * attends all of the designated session one \& session two dates and times exclusion criteria: * not a yale student * not 18 years of age or older * does not complete all survey measures * is not available for all of the designated session one \& session two dates and times * does not attend all of the designated session one \& session two dates and times
saccadometry in primary headache syndromes

Conditions: Migraine; Cluster Headache; Control; Menstrual Migraine

Summary: migraine is one of the commonest neurological disorders, affecting up to 12% of the general population, but remains relatively under-diagnosed and under-treated. migraine has a wide socioeconomic impact and brings a large economic burden; estimates suggest that disability due to migraine costs \> €27 billion per annum across europe. despite its prevalence and impact, migraine pathophysiology is poorly understood. a wider understanding of the functional changes in this disorder would be beneficial to both diagnosis and treatment. saccades are the rapid eye movements we make when moving the eyes to a new object in our visual field. reaction time studies have been used to investigate huntington's disease and parkinson's disease with great success. these use saccadic tasks (monitoring eye movements). even at rest we make approximately three saccades per second, so a lot of data can quickly be gathered with non-invasive testing. we hope to understand more of the underlying mechanisms of migraine by studying reaction time in migraine patients. our previous pilot study, with less stringent inclusion and exclusion criteria, looked at fewer patients (32 migraineurs and 32 controls), and found that migraineurs showed significantly different saccadic patterns to non-migraineurs. this study firstly seeks to corroborate the saccadometric findings of our earlier pilot study in a group of migraineurs, and secondly to explore the specificity of these findings in migraine by also studying patients with another primary headache syndrome, namely cluster headache. migraine is known to be a dynamic disorder, with previous studies showing longitudinal changes in the migraine brain. to explore this further we hope to record longitudinally (every day for 21 days) in a small subset of migraineurs to identify potential longitudinal changes in saccadic reaction time. because of the portability of the equipment this could be done in the subjects own home if they preferred.

as above

Eligibility criteria:
inclusion criteria: 1. male or female and aged between 18 and 60 years in good general health apart from suffering from headaches (test group). 2. migraine and cluster headache will be diagnosed according to ichd-ii diagnostic criteria (6). 3. migraineurs must suffer at least two migraine attacks per year and no more than 5 attacks per month. - exclusion criteria: 1. any other neurological disorder such as stroke, multiple sclerosis, epilepsy, concussion within the past year, psychiatric disorders, visual disorders. 2. use of migraine prophylactic medication in the last month or acute migraine therapy in the 3 days prior to testing. 3. patients on any medication to treat depression in their case 4. headache during testing or within 3 days before and after testing. -
the gore vbx forward clinical study: a comparison of the gore® viabahn® vbx balloon expandable endoprosthesis to bare metal stenting for patients with complex iliac occlusive disease

Conditions: Aortoiliac Occlusive Disease; Peripheral Arterial Disease

Summary: the objective of this prospective, multicenter, randomized, controlled clinical trial is to demonstrate the superiority of the vbx device for primary patency when compared to bare metal stenting in complex iliac occlusive disease.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years at time of informed consent signature * informed consent form (icf) is signed by the subject * subject can comply with protocol requirements, including follow-up * patient has symptomatic claudication, rest pain, or minor tissue loss (rutherford category 2-5) * patient has de novo or restenotic lesion(s) found in the common and/or external iliac artery(ies) * patient has: unilateral or bilateral single or multiple lesions (\>50% stenosis or chronic total occlusion) each between 4 and 11 cm in length * patient has a target vessel diameter visually estimated to be approximately between 5 mm and 13 mm * patient has a sufficient (\<50% stenotic) common femoral artery and at least one sufficient (\<50% stenotic) femoral artery (deep or superficial). * patient has at least one sufficient (\<50% stenotic) infrapopliteal run-off vessel. exclusion criteria: * life expectancy \<1 year * patient is pregnant at time of informed consent. * patient has a known allergy to stent or stent graft components (including nitinol, stainless steel, or heparin). * patient has severe chronic renal insufficiency (serum creatinine level \> 2.5mg/dl) and not undergoing hemodialysis. * patient has evidence of a systemic infection. * patient has a known intolerance to antithrombotic medications that prevent compliance with study or control device instructions for use. * patient has had vascular catheterization of the lower extremities within 30 days of randomization (excluding diagnostic angiograms for the study procedure). * patient has previous stenting in the iliac arteries. * patient has previous surgical bypass in the target limb. * patient is currently participating in another investigative clinical study unless received written approval by the sponsor. * patient has a lesion requiring drug-coated balloon angioplasty, atherectomy, lithotripsy, or any ablative device to facilitate stent delivery. * patient has an abdominal aortic artery lesion or aneurysm. * patient has a lesion that requires stent placement within 2 cm of the inguinal ligament. * patient has isolated common iliac artery stenosis that can be treated with a single device (i.e., common iliac artery stenosis that does not require kissing stents or extend into the external iliac artery). * patient has outflow disease that requires concomitant interventions (i.e. common femoral endarterectomy or femoral / tibial revascularization).
aspects associated with obstructive sleep apnea, bruxism and orofacial pain

Conditions: Bruxism; Temporomandibular Joint Disorders; Obstructive Sleep Apnea Syndrome

Summary: this study evaluated the influence of the sleep bruxism (sb), awake bruxism (ab) and obstructive sleep apnea syndrome (osas) on the signs and symptoms of temporomandibular disorders (tmd).

obstructive sleep apnea (osa) is characterized by partial or total obstruction of the upper airways. bruxism is defined as a repetitive activity of the mandibular musculature characterized by the tightening or grinding of the teeth and/or by the retrusion or propulsion of the mandible, and according to their manifestation circadian is defined as sleep bruxism (sb) or wake bruxism (ab). this prospective clinical study will be performed with adults (20 to 60 years) and elderly (\> 60 years) (who-world health organization) who will be undergone polysomnography (psg) at a private medical outpatients clinic from january to december 2019 to evaluate the influence of sb, ab, and osa on signs and symptoms of tmd. the individuals will be assessed clinically and diagnosed for tmd using the "diagnostic criteria for temporomandibular disorders", for sb and osa using psg, and ab using the smartphone application. specific statistical tests will be determined after preliminary analysis of the data (α= 0.05).

Eligibility criteria:
inclusion criteria: * adults (aged 20 to 60 years) and elderly (aged \> 60 years) (who-world health organization, 2015) who will be undergone psg at the pelotas sleep institute (isp); * adequate cognitive capacity to understand and answer the questionnaire. exclusion criteria: • those which the participants were unable to answer the questionnaires and who presented a history of epilepsy that could interfere in the results of psg.

Keywords: sleep bruxism polisomnography sleep wake disorders
strength and dexterity of less affected hand of hemiparetic cerebral palsy children

Conditions: Cerebral Palsy

Summary: the contralateral hand deficits are often masked by the complex clinical presentation of the more affected hand in children with spastic hemiparesis. thus, intervention targeting the contralateral hand is not often a component of the child's rehabilitation plan of care. the presence of bilateral hand deficits, even if subtle in the contralateral hand, may limit the transfer of unimanual gains following rehabilitation to bimanual activities of daily living tasks. however, conservation of upper-limb function of the less-affected side is highly important for individuals with hemiparesis, because this side is often employed as a compensatory 'tool' in performing activities of daily living . therefore, the current study will be conducted to determine and compare the motor abilities of the less affected hand of children with hemiparesis.

an impairment of the less affected hand of hemiparetic cerebral palsy children can be detrimental to the development of bimanual skills. it would be beneficial to identify and quantify the severity of any impairment of the less affected hand of hemiparetic cerebral palsy children. hemiparetic cerebral palsy may present with substantial deficits in hand function, because bimanual activities involve the ability to use the affected and contralateral hands together for grasp and stabilization. several authors have evaluated bimanual involvement in cerebral palsy but these studies have not compared the contralateral hand with norms. the less affected hand is widely regarded as "normal" or "unaffected" and is consequently rarely evaluated. several authors have reported incidental findings of subtle deficits in the less affected extremity, noted that hemiparetic children "also presented motor impairments in their non-paretic hand, especially in dexterity. the purpose of this study is to assess the grip ,pinch strength and dexterity of less affected hand of hemiparetic cerebral palsy children and compare with dominant hand of normal peers

Eligibility criteria:
inclusion criteria: * children will be recruited according to the following criteria: * age range between 6 and 10 years. * both sexes * the degree of spasticity rang from grade 1 to 1+ according to modified ashworth scale (appendix ii). * they can follow the order during the testing. exclusion criteria:children will be excluded from the study if they had any of the following criteria; * significant visual or auditory defect that may affect their performance. * previous orthopedic surgery for upper extremity. * injection with botulinium toxin in the last 6 months. * structural deformities in any joint or bone of the upper limbs. * practicing any form of sports.

Keywords: cerebral palsy unilateral cerebral palsy grip strength pinch strength upper limb dexterity
comparison of hfnc with niv in weaning copd

Conditions: Chronic Obstructive Pulmonary Disease With (Acute) Exacerbation

Summary: high flow nasal cannula (hfnc) has been shown to improve oxygenation and facilitate weaning in hypoxemia patients. some clinical studies show the benefits of using hfnc in copd patients, including reducing dead space and work of breathing. however, no clinical study has been to investigate the value of hfnc in weaning copd patients from invasive ventilation. thus, we proposed a randomized controlled trial to compare the use of hfnc and noninvasive ventilation (niv) in weaning copd.

high flow nasal cannula (hfnc) provides high concentration oxygen in a high flow, which exceeds patient's inspiratory flow demand, to improve oxygenation. in a recent meta-analysis of seven trials with 1771 patients, hfnc was shown to improve oxygenation and avoid intubation in patients with severe hypoxemia. the high velocity of the gas can rinse the dead space of the upper airway and reduce co2 rebreathing, reduce copd patients' work of breathing and improve the dynamic compliance of respiratory system. thus, we proposed a randomized controlled trial to investigate the value of high flow nasal cannula in weaning aecopd patients from invasive ventilation, with comparison of noninvasive ventilation.

Eligibility criteria:
inclusion criteria: * intubated patients with chronic obstructive pulmonary disease exacerbation * meeting extubation criteria (pulmonary infection control window) * age \> 21years and \< 90 years exclusion criteria: * tracheotomy * combined with severe dysfunction of other organs, including heart, brain, liver, and renal failure; * hemodynamic instability * contraindication to niv: cannot use mask, such as facial injury, burns or deformities; cannot cooperate with niv such as delirium; copious secretions with weak cough ability; gastric over distention, and vomiting; * contraindication to hfnc: rhinitis, nasal congestion, deformities or blockage. * weak cough ability with copious secretions * refuse to participate in the study

Keywords: weaning; noninvasive ventilation; high flow nasal cannula
micropulse laser for geographic atrophy

Conditions: Geographic Atrophy; Age-related Macular Degeneration

Summary: geographic atrophy (ga) causes the loss of the retinal pigment epithelium (rpe) cells in broad areas of the retina. the application of subthreshold micropulse laser spots in healthy rpe in the vicinity of the area of ga may restore the imbalance in survival factors caused by the disease (ie, the laser may decrease vascular endothelial growth factor and rpe-derived transforming growth factor beta, upregulation of pigment epithelium-derived factor). this may slow or even stop the enlargement of atrophy secondary to ga, and therefore, avoid further vision loss.


Eligibility criteria:
inclusion criteria: * ga \> 0.5 disk areas secondary to amd in both eyes * 50 years or older * the periphery of the atrophic lesions must demonstrate increased autofluorescence * best corrected visual acuity between 20/20 and 20/400 inclusive * clear ocular media * ability to provide informed consent and attend all study visits exclusion criteria: * ga secondary to other causes aside from amd * evidence of choroidal neovascularization in either eye * any prior treatment for amd, aside from antioxidants * any other ocular condition that would progress in the study period and confound visual acuity assessment * any ocular or systemic medication known to be toxic to the lens, retina or optic nerve * presence of idiopathic or autoimmune-associated uveitis * any intraocular surgery 3 months of entry * any prior thermal laser in the macula * history of vitrectomy, filtering surgery, corneal transplant or retinal detachment surgery * previous therapeutic radiation in the ocular region in either eye * any treatment with an investigational agent in the previous 60 days before study entry

Keywords: geographic atrophy age-related macular degeneration fundus autofluorescence
investigate, following cataract surgery with iol in conjunction with intracanalicular dexamethasone insert

Conditions: Glaucoma, Primary Open Angle; Cataract

Summary: randomized, controlled treatment with an intracanalicular dexamethasone (0.4mg) insert following cataract surgery with intraocular lens implant (iol) combined with minimally invasive glaucoma surgery (migs), specifically istent, istent inject or kdb in patients with primary open angle glaucoma (poag) or ocular hypertension (ohtn)

to determine treatment and patient reported outcomes, following cataract surgery with intraocular lens implant in conjunction with minimally invasive glaucoma surgery (migs) more specifically istent, istent inject or kdb with an intracanalicular dexamethasone (0.4 mg) insert, inserted four days (+/- 1 day) prior to surgery as compared to insertion on day of surgery. patients with either primary open angle glaucoma (poag) or ocular hypertension (ohtn) requiring cataract surgery with iol implant, will be separated into two groups. group 1: intracanalicular dexamethasone (0.4 mg) insertion four days (+/- 1 day) prior to cataract surgery with intraocular lens (iol) implant and migs (istent, istent inject or kdb) insertion. (patient to use antibiotic three days prior to surgery) group 2: intracanalicular dexamethasone (0.4 mg) insertion on the day of cataract surgery with intraocular lens (iol) implant and migs (istent, istent inject or kdb) insertion. (patient to use antibiotic three days prior to surgery)

Eligibility criteria:
inclusion criteria: * age 18 years and older * been diagnosed with poag or ohtn and migs (istent, istent inject or kdb) has been planned * unilateral or bilateral cataract surgery with iol has been planned * willing and able to comply with clinic visits and study related procedures * willing and able to sign the informed consent form exclusion criteria: * patients under the age of 18. * pregnancy (must be ruled out in women of child-bearing age with pregnancy test) * active infectious systemic disease * active infectious ocular or extraocular disease * unobstructed nasolacrimal duct in the study eye(s) * hypersensitivity to dexamethasone * patients being treated with immunomodulating agents in the study eye(s) * history of prior ocular surgery, including lasik or prk * history of ocular inflammation or macular edema * patients being treated with \>375mg daily of nsaids o patients on doses higher than 375mg of oral nsaids will be considered if they discontinue the medication 2 weeks prior to the study start date. * patients taking inconsistent varying doses of an nsaid on a daily basis. * patients being treated with immunosuppressants and/or oral steroids * patients with a corticosteroid implant (i.e. ozurdex) * patients with severe disease that warrants critical attention, deemed unsafe for the study by the investigator
ridge preservation comparing a ptfe nonresorbable membrane to a collagen membrane

Conditions: Clinical Efficacy

Summary: a non-resorbable ptfe (teflon) membrane will be compared to a resorbable collagen membrane when used for a post-extraction ridge preservation procedure to prevent the bone loss that typically occurs. the hypothesis is that there will be no difference in the clinical and histologic results between the two membranes.

patient selection 30 patients will be selected that meet the following criteria: inclusion criteria 1. have one non-molar tooth requiring extraction that will be replaced by a dental implant. the site must be bordered by at least one tooth. 2. healthy male or female who is at least 18 years old. 3. patients must sign an informed consent approved by the university of louisville human studies committee. exclusion criteria 1. patients with debilitating systemic diseases, or diseases that have a clinically significant effect on the periodontium. 2. presence or history of osteonecrosis of jaws. 3. patients who are currently taking iv bisphosphonates or who had iv treatment with bisphosphonates irrespective of duration. 4. patients who have been treated with oral bisphosphonates for more than three years. 5. patients with an allergy to any material or medication used in the study. 6. patients who need prophylactic antibiotics. 7. previous head and neck radiation therapy. 8. chemotherapy in the previous 12 months. 9. patients on long term nsaid or steroid therapy. 10. pregnant patients.

Eligibility criteria:
inclusion criteria: 1. have one non-molar tooth requiring extraction that will be replaced by a dental implant. the site must be bordered by at least one tooth. 2. healthy male or female who is at least 18 years old. 3. patients must sign an informed consent approved by the university of louisville human studies committee. - exclusion criteria: 1. patients with debilitating systemic diseases, or diseases that have a clinically significant effect on the periodontium. 2. presence or history of osteonecrosis of jaws. 3. patients who are currently taking iv bisphosphonates or who had iv treatment with bisphosphonates irrespective of duration. 4. patients who have been treated with oral bisphosphonates for more than three years. 5. patients with an allergy to any material or medication used in the study. 6. patients who need prophylactic antibiotics. 7. previous head and neck radiation therapy. 8. chemotherapy in the previous 12 months. 9. patients on long term nsaid (nonsteroidal anti-inflammatory drug) or steroid therapy. 10. pregnant patients. -

Keywords: regeneration bone regeneration grafting, bone allograft xenograft