Kornimate/medical-research-clean huggingface dataset:
healthy moms-healthy kids: reducing maternal depression for better outcomes in head start children

Conditions: Maternal Depression; Parenting Behavior; Health; Interpersonal Relationships; Goal Directed Behavior; Child Behavior; Child School Readiness

Summary: maternal depression is a pervasive problem that disproportionately affects low-income mothers. the effects of depression on mothers and their parenting result in many negative outcomes for children, particularly in terms of school readiness. the proposed research will build on a successful partnership between the university of southern california school of social work (usc) and children's institute, inc. (cii) to implement and evaluate an evidence-based intervention, interpersonal psychotherapy for group (ipt-g), for head start mothers with depression or dysphoric mood with the goal of reducing their depression and promoting positive changes for both mothers and children. the objectives of the study are: (1) adapt ipt-g for a head start population of mothers with depression; (2) implement ipt-g via a randomized controlled trial in head start centers in los angeles county operated by cii; (3) evaluate the effects of the intervention on maternal depression, parenting behaviors, goal-directed behavior, interpersonal relationships, physical health, and child behavior and school readiness; and (4) develop a manual for use of the intervention in head start and disseminate findings nationally. the study will feature 2 groups of 60 mothers each, randomized by head start site; one will receive the intervention and the other services as usual. outcomes for both mothers and children will be tracked for 2 years after the intervention, allowing for the evaluation of short- and long-term effects. the intervention will be delivered by head start mental health workers under the supervision of scott stuart, a national trainer of the intervention. this intervention has the potential to be a low-cost, high-impact intervention that can be replicated to other head start sites across the country to improve the lives of head start children and families.


Eligibility criteria:
inclusion criteria: * mothers of children in head start with scores on screening measure that are in depressed or possibly depressed range to be assigned to intervention or tau. also will have additional control group of non depressed mothers exclusion criteria: * not able to function in group environment

Keywords: maternal depression interpersonal psychotherapy school readiness
anatomical and functional outcomes of perigee and apogee mesh in total pelvic floor reconstruction versus gynecare prolift

Conditions: Pelvic Organ Prolapse

Summary: the investigators designed a prospective study in this article to evaluate the efficacy, the life quality and the complications of two different meshes of type i (one is perigee/apogee, the other is named gynecare prolift) versus traditional surgery, and also studied the influence of some surgical procedures on the prognosis.

pelvic organ prolapse is defined as a downward descent of the pelvic organs that results in the protrusion of vagina, uterus, or both. the investigators designed a prospective study in this article to evaluate the efficacy, the life quality and the complications of two different meshes of type i (one is perigee/apogee, the other is named gynecare prolift) versus traditional surgery. the investigators also studied the influence of some surgical procedures on the prognosis. in this study，the investigators divided the patients randomly into three groups :the group a was a total of 91 patients who accepted transvaginal hysterectomy and total pelvic floor reconstruction combined perigee and apogee polypropylene mesh(pa)；the group b was a total of 97 patients who accepted transvaginal hysterectomy and total pelvic floor reconstruction with gynecare prolift polypropylene mesh；the group c was a total of 70 patients who accepted transvaginal hysterectomy and anterior and posterior vaginal wall repair without any mesh.the investigators did pop-q measurements and questionnaire preoperatively and postoperatively and recorded volume of bleeding，day of postoperative indwelling catheter and the mesh complications。

Eligibility criteria:
inclusion criteria: * patients with stage iii \~ iv degree of anterior and posterior vaginal wall prolapse and uterine prolapse (total pelvic floor prolapse) by the pelvic organ prolapse quantification system (pop-q) were included exclusion criteria: * simple anterior or posterior wall prolapse, simple uterine prolapse, combined with stress urinary incontinence, overactive bladder (oab), pelvic floor repair surgery history and recurrent patients * local or systemic conditions that would preclude surgery or affect healing such as restricted leg motion (inability to conform to the lithotomy position) * vaginal bleeding;coagulation disorders * infection,or uncontrolled hypertension and diabetes mellitus * pelvic cancer and radiation to the pelvic area in the previous 6 months. * also women of reproductive age, and planning of pregnancy were also excluded for mesh usage.

Keywords: quality of life vaginal mesh mesh complications
cognitive therapy for suicidal older men in primary care settings

Conditions: Suicide, Attempted

Summary: this study will assess the effectiveness of cognitive therapy in reducing the incidence of suicide ideation and behavior in older men in a primary care setting.

older adult males have the highest suicide rate of any age group in the u.s. over 70 percent of older suicide victims have been to their primary care physician within a month of their death, many with a depressive illness that was not detected. however, most research concerning treatments for suicide ideation and behavior has focused on adolescents and young adults. very few treatments have been developed to reduce suicide ideation and behavior in men aged 60 and above. this study will assess the effectiveness of specialized cognitive therapy versus typical treatment in treating older men with suicide ideation. participants in this two-year, single-blind study will be randomly assigned to receive either cognitive therapy combined with enriched care or enriched care alone. participants will be identified in primary care settings as having experienced suicide ideation in the past month. cognitive therapy will be provided by ph.d.-level therapists and will be geared specifically toward older men with suicidal tendencies. the enriched care condition will consist of the usual care that individuals receive for suicide prevention, plus assessment and referral services provided by independent evaluators and study case managers. all participants will be assessed pre-treatment to attain baseline measures of suicide ideation, hopelessness, and depression. study visits will occur at baseline and months 1, 3, 6, 12, 18, and 24 to assess suicide ideation. self-report and clinician-administered measures will be used to assess participants' progress. for information on a related study, please follow this link: http://clinicaltrials.gov/show/nct00218725

Eligibility criteria:
inclusion criteria: * currently experiencing death ideation or suicidal ideation (total score greater than 0 on the scale for suicide ideation) * english-speaking * lives within the area served by the research unit * able to provide at least 2 verifiable contacts (typically family members) exclusion criteria: * requires priority treatment for an acute, unstable, or severe axis iii disorder (e.g., dementia) * requires priority treatment for another debilitating problem (e.g., severe alcohol or drug dependence, mania, severe anorexia) * suffers from a psychotic disorder or psychotic thought processes * exhibits self-mutilating behavior without any intent to commit suicide (e.g., burning oneself with a cigarette)

Keywords: cognitive therapy suicide older men death ideation primary care
study of the effectiveness of etiasa® (sustained release 5-aminosalicylate) in maintenance treatment of ulcerative colitis (uc)

Conditions: Ulcerative Colitis

Summary: the purpose of the protocol is to assess the effectiveness of etiasa® for preventing relapse in chinese patients with quiescent uc.


Eligibility criteria:
inclusion criteria: * male or female patient ≥ 18 years old and ≤ 65 years old * patient has provided written informed consent to participate in the study after the purpose and nature have been clearly explained to him/her; * patient with documented diagnosis of mild-moderate ulcerative colitis (uc). the "documented diagnosis" should include a typical histology observed at least once in the course of the disease; * have a documented history of uc that has been successfully maintained in complete steroid-free remission for at least 1 month prior to study entry; * the modified mayo score ≤ 2, without subscore \>1, which is supported by a rectum-sigmoidoscopy or a colonoscopy; * regimen of maintenance of remission contains etiasa® * patient mentally and physically able to answer the questionnaire. exclusion criteria: * have a history of allergy or hypersensitivity to salicylates, 5-aminosalicylates, or any component of etiasa®; * pregnant and breastfeeding women, approaching childbirth female or unwilling to take birth control measures during the study; * a topical 5-aminosalicylate agent is included in the regimen; * patients with infectious colitis (positive for germs, ovum or parasites causing bowel disease); * treated with the other study drug at enrollment, or within past 3 months of enrollment; * serious underlying disease other than uc which in the opinion of the investigator may interfere with the patient's ability to participate fully in the study; * crohn's disease; * pancreatitis; * known bleeding disorders; * potentially unreliable patients, and those judged by the investigator to be unsuitable for the study.
the effects of mindfulness-based stress reduction on attention and pain-related symptoms in chronic pain patients

Conditions: Pain

Summary: the main purpose of this study is to determine the degree to which mindfulness-based stress reduction, a group-based psychological therapy that includes mindfulness meditation exercises, reduces depression, anxiety, stress, pain intensity, and interference of pain with daily life among adult chronic pain patients. the second purpose is to examine the role of attention in improving psychological and physical health for chronic pain patients.


Eligibility criteria:
inclusion criteria: * adult chronic pain patients who are proficient in english * capable of interacting with others in a group setting * capable of working with a computer exclusion criteria: * alcohol or drug abuse (past history is acceptable as long as their situation has been stable for at least 3 months) * psychiatric psychosis (patients who have a past history of schizophrenia are eligible as long as they are currently stable) * current major depressive disorder * current severe social phobia * at immediate risk for suicide * cerebral lesions or tumors (unless medically and cognitively stable) * neurological disease * medically unstable * cognitively unstable * previously participated in a mindfulness meditation program

Keywords: meditation mindfulness attention chronic pain depression anxiety stress acceptance pain intensity pain disability
diet and well-being of young danish children born by obese mothers

Conditions: Growth; Overweight; Metabolic Syndrome; Obesity

Summary: the overall aim is to provide a detailed description of growth, development and risk factors for later disease, especially obesity and metabolic disease in infants born by obese mothers and to compare them with a group of infants born by mothers without any restriction in prepregnancy bmi (skot i).

the skot ii is a prospective cohort study that includes children of obese mothers with a body mass index over 30 kg/m2. these mothers were invited to skot ii while participating in a randomised study at hvidovre hospital, copenhagen. the families were invited to three examinations, when the children were 9, 18 and 36 months of age. a total of 184 children were included in 2010. the examinations and the collecting of data are designed in the same way as skot i, a study of healthy children born by non-obese mother. the examinations takes place at department of nutrition, exercise and sports, frederiksberg, denmark. following data were collected during the examinations: anthropometry (weight, height, age- and sex specific z scores for body composition, triceps- and subscapularis skinfolds), background interview (e.g. infant feeding, household income, the parent's educational level, allergy and chronic diseases), blood pressure (systolic, diastolic and mean arterial pressure), faeces- and urine samples, blood samples (at 9 and 36 months of age), bio impedance (at 36 months of age), 4 day diet registration, general questionnaire (e.g. sleep, daycare, attendance and use of screen devices), psychomotor questionnaire (motoric development) and 7 day physical activity monitoring (at 36 months of age).

Eligibility criteria:
inclusion criteria: * healthy singletons born at term (week 37-43) with no disease that could influence food intake or growth. born by obese mother (bmi ≥ 30 kg/m2) mothers participated in a intervention study at hvidovre hospital exclusion criteria: * born preterm (before week 37) non-danish speaking parents. chronic disease that is expected to influence growth or food intake.

Keywords: growth, infancy, children, diet, breastfeeding complementary feeding early life programming tracking physical activity
interest of a skin transilluminator (such as the veinviewer®vision device) for peripheral venous catheter placement in the obese patient

Conditions: General Surgery

Summary: placement of a peripheral venous catheter (pvc) is the most common invasive procedure in anaesthesia and perhaps even in the field of medicine as a whole.

placement of a peripheral venous catheter (pvc) is the most common invasive procedure in anaesthesia and perhaps even in the field of medicine as a whole. this procedure may be challenging in the obese patient - even for the most experienced healthcare professionals. in a study, pvc placement was considered to be difficult in 46% of obese patients but only 13% of non-obese patients. placement of a central venous catheter is an option when pvc placement is impossible, although central access is associated with a non-negligible risk of complications (pneumothorax, infection, arterial puncture, etc.). facilitating peripheral venous access in obese patients should shorten the time required for pvc placement, decrease the number of perfusion attempts (a source of dissatisfaction and discomfort for the patients) and limit the use of a central venous catheter. although a number of novel vein visualisation devices (such as the veinviewer®vision from christie medical) have been developed to guide pvc placement, there are no literature data on the value of these devices in the management of difficult venous access in obese patients.

Eligibility criteria:
inclusion criteria: * all obese adult patients scheduled for surgery. * social security coverage exclusion criteria: * age \<18. * contra-indication to pvc placement. * legal guardianship.

Keywords: obese patients peripheral venous catheter
prevention of severe postpartum hypertension

Conditions: Hypertension

Summary: the purpose of this study is to determine whether postpartum administration of furosemide to women with antepartum hypertensive disorders (gestational hypertension, preeclampsia) or elevated blood pressure in the first 24 hours following delivery reduces severe postpartum hypertension.


Eligibility criteria:
inclusion criteria: women \> 18 years of age or emancipated minors women undergoing vaginal or cesarean delivery at \> 23 weeks gestation with: * antepartum diagnosis of gestational hypertension * antepartum diagnosis of preeclampsia * antepartum diagnosis of preeclampsia with severe features * mild hypertension (\<150/100) in first 24 hours following delivery exclusion criteria: * chronic hypertension * allergy to furosemide * pre-existing hypokalemia (serum k \< 3.0 meq/l) * chronic kidney disease * serum cr \> 1.1 * inability to obtain informed consent * pre-existing diuretic use * oliguria

Keywords: postpartum preeclampsia gestational hypertension
efficacy of prucalopride in critically ill patients with paralytic ileus

Conditions: Paralytic Ileus; Critically Ill

Summary: paralytic ileus is a common intestinal dysfunction in critically ill patients. there are still no established the effective medications except correcting the primary causes and prokinetics trial which limited in efficacy and potential adverse events.

prucalopride, a highly selective 5-ht4 receptor agonist, accelerates gastrointestinal transit which may reduce severity of ileus. furthermore, there is no report of serious cardiac and neurological side effects. we aim to evaluate the efficacy of prucalopride as a prokinetic of choice on paralytic ileus in critically ill patients.

Eligibility criteria:
inclusion: * medical patients with apache ii score \>= 15 * paralytic ileus: small bowel diameter \>= 4 cm or large bowel diameter \>= 6 cm exclusion: * no current prokinetic use * severe peritonitis or bowel inflammation * esrd needed hemodialysis

Keywords: prokinetic prucalopride
ritodrine in oral maintenance of tocolysis after active preterm labor

Conditions: Pregnancy

Summary: this is a trial comparing the efficacy of oral ritodrine in the form of sustained release capsules for the maintenance of uterine quiescence after successfully treated episode of threatened preterm labor.

we randomized 120 women with singleton pregnancy who were successfully treated for threatened preterm labor before 34 completed weeks to receive either maintenance tocolysis with two 40 mg ritodrine sustained release capsules three times a day (study group, n=62) or no treatment (control group, n=58) for three days. the primary outcome measure was the recurrent episode of threatened preterm labor within 72 hours, which was defined as regular palpable uterine contractions and change in cervical effacement and/or cervical dilatation on clinical examination. secondary outcome measures included the incidence of preterm birth, neonatal adverse outcomes, and maternal side effects.

Eligibility criteria:
inclusion criteria: * pregnancy between completed 24 to 24 weeks * successfully treated episode of threatened preterm labour by intravenous preparations * no uterine contractions exclusion criteria: * uterine contractions (painful, clinically palpable, or present on cardiotocography) * cervical dilatation of ≥5 cm * clinical and laboratory signs of infection defined as offensive vaginal discharge on clinical examination, vaginal ph ≥5, white blood cell (wbc) count \>16×109/l, and c-reactive protein (crp) \>10 mg/l * positive findings of microorganisms rather than normal vaginal flora on high vaginal swab * any signs of fetal distress according to cardiotocography, doppler assessment of blood flow in umbilical artery, and biophysical profile of \<8.

Keywords: pre term labor therapy maintenance
validation of new virtual reality treatment for children with lazy eye using the vedea amblyopia therapy (vat)

Conditions: Amblyopia, Anisometropic; Amblyopia Strabismic; Amblyopia

Summary: the purpose of this clinical study is to validate the effectiveness of the vedea amblyopia therapy (vat) as a treatment for children with lazy eye. the main question it aims to answer is to prove that the vat is as effective or more effective than the current gold standard for treating children with lazy eye. this is occlusion therapy by patching the dominant eye. participants will play vr-games specifically designed for children with lazy eye for 30 minutes per day, 5 days per week for 16 weeks. this group of children will be compared to children that undergo regular occlusion therapy to see how both treatments options compare.


Eligibility criteria:
inclusion criteria: * wearing the full corrected refraction for ≥14 weeks to adapt to the glasses * diagnosed with an unilateral anisometropic, strabismic and/or deprivation amblyopia. amblyopia was defined as an intraocular difference (iod) in visual acuity (va) of 0.2 log mar (2 lines) or more. angle of strabismus ≤ 10 prism diopters at near and distance fixation. current clear media (in case of deprivation amblyopia after successful surgery). * currently under treatment or starting treatment for unilateral amblyopia * participants must have easy access to an android device equal to or higher than a samsung galaxy s8 * written informed consent by parents or legal guardians exclusion criteria: * current treatment with atropine penalisation * documented history of severe negative side effects that occur with exposure to vr usage (eg. seizures or epileptic spasms) * photosensitivity * no developmental delay * coexisting ocular pathology or systemic diseases

Keywords: rct children virtual reality
thymic stromal lymphopoietin (tslp) in vitiligo

Conditions: Vitiligo

Summary: study \& verify the hypothesis of the involvement of tslp in the pathogenesis of vitiligo in comparison to their levels in the healthy control persons.


Eligibility criteria:
inclusion criteria: * • patients with generalized non-segmental vitiligo. * both sexes. * age \< 18 years old age. * new cases or cases not receiving any medication for at least 3 months ago. exclusion criteria: * • age: patients \< 18 years. * segmental or universal vitiligo. * pregnant and lactating females. autoimmune diseases
evaluation of multifocal erg and visual field changes after vitrectomy and ilm peeling

Conditions: Epiretinal Membrane

Summary: to evulate changes in mferg, vf and oct after viterctomy associated with ilm peeling.

macular epiretinal membrane (erm) is a disorder of the vitreomacular interface characterized by ﬁbrocellular proliferation on the anterior surface of the internal limiting membrane (ilm) of the macula. pars plana vitrectomy with erm removal and inner limiting membrane peeling is the standard surgical treatment for an erm. ilm peeling is performed to eliminate the scaffold for myoﬁbroblast proliferation and any microscopic erm in order to prevent erm recurrence. ilm peeling is indicated for other pathologies other than erm such as, diabetic macular edema, and macular hole. ilm peeling is a traumatic procedure that may have many effects on the underlying inner retinal layers that may lead to changes in retinal function. retinal edema, eccentric scotoma, dissociation of the nerve fiber layer, iatrogenic punctuate chorioretinopathy, and subretinal, retinal, and vitreous hemorrhage are well described secondary to the surgical trauma of peeling in addition to stain toxicity. investigation of these changes may assist in aiding the development of minimally traumatic techniques for ilm removal . evaluation of functional changes may include visual field and multifocal electroretinography assessment. visual field defect after vitrectomy a well known post operative complication usually in eyes that underwent fluid air exchange, the cause of visual field defect remain unclear. optical coherence tomography (oct), imaging is done to evaluate inner retinal layers after ilm peeling,high myopic eyes might develop more severe, "scattered" inner retinal defects after ilm peeling. multifocal electroretinography (mferg), has been used to assess visual function and the electrophysiologic responses of multiple retinal locations of the macular area

Eligibility criteria:
inclusion criteria: 1. idiopathic erm, 2. primary full thickness macular hole, 3. lamellar macular hole, and 4. vitromacular traction exclusion criteria: * 1-patients with a secondary erm, 1. diabetic retinopathy, 2. venous occlusion, 3. retinal detachment, 4. uveitis, and 5. trauma. 2-other ocular pathologies that could interfere with the functional results 1. dense cataract , 2. glaucoma, and 3. previous retinal surgery