Kornimate/medical-research-clean huggingface dataset:
research on quantification of vr(virtual reality) related stress and relaxation

Conditions: Stress, Psychological; Motion Sickness; Visual Fatigue

Summary: current virtual reality device makes motion sickness and visual fatigue having limitation for recreation and other clinical approaches. still there is no standardized quantification of motion sickness and visual fatigue measurement with objective approach. current biofeedback accompanied with virtual reality would be promising tool for stress relief.

current virtual reality device makes motion sickness and visual fatigue having limitation for recreation and other clinical approaches. still there is no standardized quantification of motion sickness and visual fatigue measurement with objective approach. after quantification and improvement with these shortcomings, current biofeedback accompanied with virtual reality would be promising tool for stress relief. this research aims to measure objective motion sickness and visual fatigue with psychological stress in highly stressed group, and to compare between stress relief with existing biofeedback only approach and relief with mixed biofeedback and virtual reality relaxation.

Eligibility criteria:
inclusion criteria: * scored at least 20 on the pss-10 (perceived stress scale 10) to verify highly psychological stressed participants at the baseline visits. exclusion criteria: * the existence of a current major depressive disorder or panic disorder, psychotic disorder (e.g., schizophrenia or delusional disorder), bipolar affective disorder,active alcohol or drug use disorder, neurological illness including significant cognitive impairment or parkinson's disease, mental retardation, significant medical conditions, epilepsy, histories of alcohol or drug dependence, personality disorders, or brain damages during the screening and baseline visits, per the mini-international neuropsychiatric interview (sheehan et al., 1998) according to the diagnostic and statistical manual of mental disorders, fifth edition (dsm-5) * the existence of active disease in both orbital parts

Keywords: stress virtual reality motion sickness visual fatigue biofeedback
comparing the burden of illness of hemophilia in the developing and the developed world

Conditions: Hemophilia A; Hemophilia B

Summary: because of high cost, persons with hemophilia in many developing countries cannot afford adequate treatment. for example, many persons with hemophilia in india and china are only rarely treated with factor replacement in response to bleeds, and as a result many have developed significant arthropathy and disability. a pilot study in china estimated the mean hemophilia joint health score (hjhs) at 13.1 (sd 9.03) suggesting that these children had highly prevalent, severe joint disease. the lack of relationship between the hjhs and treatment history suggests overall inadequate therapy. the proposed study will quantify the burden of arthropathy, physical disability, and quality of life (qol) in boys with hemophilia in brazil - where comprehensive treatment is just beginning to be widely available. this study will also provide an opportunity to compare these outcomes to those observed in canada, where the dominant therapy has become life-long prophylaxis.

in order to quantify the burden of illness in hemophilia, and to study the response to different treatments, it is necessary to have quantitative outcome measures of high validity and reliability. the international prophylaxis study group (ipsg - chair dr. victor blanchette) was established in 2001 with the stated purpose of developing and testing outcome tools for this purpose. the group has developed a magnetic resonance imaging (mri) score for quantifying arthropathy (representing the domain of structure and function domain in the icf framework), a quantitative physical examination score, and the hemophilia joint health score or hjhs, to replace the older and less sensitive world federation of hemophilia (wfh) score (representing the domain of structure and function in the icf). in addition canadian investigators have also developed a quality of life measure for boys with hemophilia, the canadian hemophilia outcomes kids' life assessment tool or cho-klat (representing the domain of participation in the icf). we will use these tools, and other validated measures, to begin to determine the burden of hemophilia in brazil and compare it to the burden of disease in canada. additionally, we will use this study to demonstrate the validity of these tools in the brazilian population.

Eligibility criteria:
inclusion criteria * hemophilia a or b moderate or severe as determined by serum factor activity ≤ 5% * age 7 - 18 yrs. inclusive * at least one parent or guardian fluent in written portuguese or english and able to complete the study outcome questionnaires. exclusion criteria * none (children with inhibitors will be allowed into the study for 2 reasons: i) our study aims to document the health of persons with hemophilia in a generalizable way, ii) not all children will have had inhibitor testing done.)

Keywords: hemophilia burden of illness pediatric quality of life disability participation
long term follow up study of predictive markers in ghd and ts children

Conditions: Growth Hormon Deficiency; Turner Syndrome in Pre-pubertal Children

Summary: primary objective is to assess the relationship between changes from serum biomarkers observed after 1 month of saizen® therapy and change in height, weight after up to 5 years of treatment with growth hormone in children with growth hormone deficiency (ghd) and turner syndrome (ts).

this study is an observational study that will collect data from patients enrolled in a previous study (predict, nct 00256126). data such as auxological parameters (height, weight, tanner stage, bone age will be collected as well as gh treatment use (including dose and adherence to the treatment). because for some countries the start of this long term follow up study will take place more than one year after subjects have completed the initial study (predict) retrospective data may be collected (if subjects agree) as well as prospective data. when available laboratory parameters such as igf-1, igfpb-3, fasting glucose, fasting insulin, tsh and t4 will also be collected. this data will be collected yearly during the normal follow up visits during 5 years.

Eligibility criteria:
inclusion criteria: * have completed the predict study (nct 00256126) * followed up at least 1 year when still under treatment after completion of predict trial * parent's or guardian's written consent given before any data collection exclusion criteria: * use of an investigational drug or participation in another interventional clinical trial since discontinuation of predict trial

Keywords: growth hormon deficiency and turner syndrome in pre-pubertal children long term follow-up of predictive markers
evaluation of tdcs efficacy in enduring anorexia nervosa

Conditions: Anorexia Nervosa

Summary: approximately 20% of anorexia nervosa cases do not respond to conventional management strategies: cognitive behavioral therapy, weight gain contract, drug treatments, etc ... - whether they are applied outpatients or during very long hospitalizations. these situations of chronic evolution are characterized by a high rate of mortality. brain stimulation could be an alternative therapy for these patients. tdcs (transcranial direct current stimulation) is a non-invasive stimulation technique that has demonstrated beneficial effects in other psychiatric conditions such as major depression or schizophrenia. the objectives of the study will be to evaluate the efficacy of tdcs in anorexia nervosa resistant to conventional treatments on weight gain, eating behavior, psychological and nutritional behavioral scales, cognition, connectivity and brain activity.


Eligibility criteria:
inclusion criteria: * diagnostic and statistical manual of mental disorders (dsm)-5 anorexia nervosa criteria * body mass index (bmi) \< 17kg/m2 * conventional treatment failure over the last 12 months * refusal or no indication of artificial nutrition exclusion criteria: * artificial nutrition * other chronic diseases * drug use (except tobacco) * pregnancy * edinburgh score \< 14

Keywords: brain stimulation body mass index
surveillance of metabolic parameters in patients with colorectal cancer

Conditions: Colorectal Cancer

Summary: a prospective, single center, cohort study for surveillance of metabolic parameters in patients who will receive chemotherapy after surgical resection of colorectal cancer

primary objective - incidence of newly developed diabetes mellitus in patients with colorectal cancer after post-operative chemotherapy secondary objective - pre-operative incidence of diabetes and characteristics of metabolic parameters of patients with colorectal cancer; incidence of developed poorly controlled glucose level in diabetic patients with colorectal cancer after post-operative chemotherapy; 3-year recurrence-free survival according to status of diabetes and metabolic parameters; 5-year recurrence-free survival according to status of diabetes and metabolic parameters

Eligibility criteria:
inclusion criteria: * who will get surgical resection for colorectal cancer * who has diagnosed with diabetes * who met the criteria for testing of diabetes in asymptomatic adult individuals * criteria for testing for diabetes in asymptomatic adult individuals * overweight (bmi\>25 kg/m2\*) and have additional risk factors (physical inactivity, first-degree relative with diabetes, high-risk race/ethnicity (e.g., african american, latino, native american, asian american, pacific islander), women who delivered a baby weighing 0.9 lb or were diagnosed with gdm, hypertension (\>140/90 mmhg or on therapy for hypertension), hdl cholesterol level ,35 mg/dl (0.90 mmol/l) and/or a triglyceride level \>250 mg/dl (2.82 mmol/l), women with polycystic ovarian syndrome, hba1c \>5.7%, igt, or ifg on previous testing, other clinical conditions associated with insulin resistance (e.g., severe obesity, acanthosis nigricans), history of cvd) exclusion criteria: * previously exposed to surgery or chemotherapy for colorectal cancer * second primary malignancy (except in situ carcinoma of the cervix or adequately treated basal cell carcinoma of the skin or prior malignancy treated more than 5 years ago without recurrence * presence of cns metastasis * not able or willing to give informed consent * any patients judged by the investigator to be unfit to participate in the study

Keywords: colorectal cancer diabetes metabolic parameters surveillance
non-antibiotic prescribing for acute upper respiratory tract infection

Conditions: Acute Upper Respiratory Tract Infection

Summary: some acute upper respiratory tract infection(auri) in children is characterized by fever and vomiting,and it is one common reason for visiting a pediatrician. white blood count(wbc) usually increased in this children patients,hence antibiotics are often prescribed properly assumed. in the present study, it was hypothesized that it was not necessary to prescribe amoxicillin for the children.

after inclusion of eligible children patients,one group was prescribed amoxicillin,and another not.

Eligibility criteria:
inclusion criteria: * acute upper respiratory tract infection * fever * vomiting * increased white blood cell exclusion criteria: * 0ther symptoms of digestive system * headache

Keywords: non-antibiotic prescribing acute upper respiratory tract infection white cell count vomiting
short course regimens for treatment of pkdl (sudan)

Conditions: PKDL - Post-Kala-Azar Dermal Leishmanioid

Summary: this is an open label, randomized non comparative phase ii clinical trial conducted on parallel groups, to assess the safety and efficacy of the combination of paromomycin (20 mg/kg/d) im for 14 days and miltefosine (allometric dosing) oral for 42 days, and a combination of ambisome® (20 mg/kg total dose) iv over 7 days and miltefosine oral for 28 days (allometric dosing) for the treatment of pkdl patients in sudan.


Eligibility criteria:
inclusion criteria: * confirmed pkdl case by clinical presentation and demonstration of parasites by microscopy in a skin smear or by pcr, with documented stable or progressive disease for at least 6 months or grade 3 pkdl * male or female patients aged 6 to 60 years * written voluntarily informed consent is obtained from the patient, or his guardian if the patient is \ 12 to \<18, assent from the children is also needed in addition to the guardian's consent. exclusion criteria: * patients who had prior treatment of pkdl within the last 1 year * pregnant and lactating women and women of childbearing age (12 to 55 years) who do not accept to have a pregnancy test and who do not agree to use contraception during treatment period and for 5 months after the end of treatment. * patients with signs and symptoms of severe diseases: defined as suffering from a concomitant severe infection such as tb or any other serious known underlying disease (cardiac, renal, hepatic), * severe malnutrition defined by bmi for age who reference curves for gender, z score \ 19 years old * patients with haemoglobin \< 5g/dl * patients with known skin disease * patients with abnormal liver function (alt and ast) tests of more than three times the normal range. * patients with total bilirubin levels \>1.5 times the upper normal range * patients with serum creatinine above the upper limit of normal range * patients with serum potassium \< 3.5 mmol/l * patients with pre-existing clinical hearing loss based on audiometry at baseline * patients with a positive hiv test as applicable * patients / guardian not willing to participate * patients with history of allergy or hypersensitivity to the relevant study drug * patients on immunomodulators therapy
intrafractional head movement during radiosurgery

Conditions: Brain Metastases, Adult

Summary: this study investigates the intrafractional accuracy of a frameless thermoplastic mask used for head immobilization during stereotactic radiotherapy. non-invasive masks cannot completely prohibit head movements. previous studies attempted to estimate the magnitude of intrafractional inaccuracy by means of pre- and postfractional measurements only. however, this might not be sufficient to accurately map also intrafractional head movements. intrafractional deviation of mask-fixed head positions is measured in five patients during a total of 94 fractions by means of close-meshed repeated exactrac measurements conducted during the entire treatment session. from the obtained data the investigators evaluate the need to adjust safety margins around the gross tumor volume (gtv) whenever the investigated thermoplastic mask is used instead of invasive ring fixation.


Eligibility criteria:
inclusion criteria: * single intracranial tumour or metastasis * stereotactic radiation therapy planned * immobilization with thermoplastic mask
deucravacitinib adherence study

Conditions: Psoriasis

Summary: psoriasis patients are very poorly adherent to topical treatment. if adherence issues are ignored, poor adherence may limit the real-world efficacy of deucravacitinib, too. forty psoriasis patients recruited from wake forest baptist health dermatology clinic will be enrolled. twenty will be randomized to a reporting intervention designed to promote better adherence and the remaining 20 patients will serve as controls who will not receive a reporting intervention. through qualitative interviews of the 40 patients recruited, we plan to study the behaviors of the most adherent patients to better understand specific beliefs and behaviors of adherent patients and to identify practical, modifiable factors that can improve adherence. we will also compare treatment outcomes and efficacy of deucravacitinib between the most and least adherence patients.

study objectives * primary objective: the primary objective of the proposed study is to identify adherence outliers (high and low adherence), specific beliefs, and behaviors that correspond to better and worse adherence to oral treatment of psoriasis. * secondary objective: the investigators will study the efficacy and safety of deucravacitinib in patients who are highly adherent to treatment compared to patients who do not take the medication as directed (including both those who undertreat and overtreat). * safety endpoints will include reported adverse events. * for the characterization of adherence to deucravacitinib, adherence endpoints will include the proportion of subjects with 80% or greater adherence, days with missed treatment, days with overuse, and premature discontinuation.

Eligibility criteria:
inclusion criteria: * patients with moderate-to-severe plaque psoriasis. standard criteria for moderate-to-severe plaque psoriasis will be used (bsa greater than or equal to 3% or face/palm/sole/genital involvement or severe effect on quality of life). * subject must be 18 years of age or older. * subject must have a working knowledge of english. * approved birth control methods required for females of childbearing potential. * baseline tb test. exclusion criteria: * patients without a diagnosis of moderate-to-severe plaque psoriasis. * patients under 18 years of age. * patients with severe or unstable comorbid conditions. * patients with active malignancy or malignancy in past 5 years (not including appropriately treated cutaneous basal and cutaneous-limited squamous cell carcinomas). * patients who are pregnant or breastfeeding. * patients with any other skin condition that prohibit or confound the ability of the investigator to interpret skin findings. * patients with active substance or alcohol abuse disorder; or history of substance/alcohol abuse disorder within 6 months prior to study enrollment. * history of, or active, severe depression and/or suicidality. * patients with active or latent tuberculosis as determined by quant-tb baseline testing * patients that are taking concomitant biologics, systemics for the treatment of psoriasis and/or phototherapy.
cleft palate with intravelar veloplasty repair

Conditions: Cleft Palate

Summary: cleft palate repair is the most important component of cleft surgery, not only in that it determines the outcome as far as speech and communication are concerned, but also in that it potentially has the greatest impact on maxillary growth and the dental arch relationship. sommerlad technique has been described as a more physiological approach, aiming to restore the anatomy of the velum. this technique, often described as radical intravelar veloplasty, has the following distinctive components: a radical retroposition of velar musculature (m. levator veli palatini, m. palatoglossus, and m. palatopharyngeus), combined with minimal dissection of the hard palate, a tensor tenotomy, and the repair of the m. levator sling


Eligibility criteria:
inclusion criteria: * patients with isolated cleft palate age from 9 months to 18 years. * patients with submucous cleft. * velopharyngeal incompetence (vpi) for palatal re-repair. exclusion criteria: * medically unfit patients. * syndromic patients with cleft lip and palate. * patients with cleft palate associated with multiple congenital anomalies. * patients with neurological disorders.
effect of listening to standardized music sequences on preventing postoperative pain in proctologic surgery

Conditions: Hemorrhoid; Anal Fistulas; MUSICAL THERAPY; Anal Fissure and Fistula

Summary: the study, "effect of listening to standardized music sequences on preventing postoperative pain in proctologic surgery," aims to evaluate the impact of preoperative listening to standardized music sequences on postoperative pain in patients undergoing proctologic surgery (for hemorrhoids, fistulas, or anal fissures). this research will assess the influence of preoperative music on postoperative pain management, the use of analgesics after surgery and during the following month, and its effect on the quality of life post-surgery. musico-procto is an interventional, randomized study involving two groups (patients will be randomly assigned to either the music intervention or control group). the study is monocentric, conducted at clinique saint vincent in france, and includes 550 participants. participants will be followed for 28 days, while the overall study duration will span 28 months. to participate, individuals must: be aged 18 or older. be affiliated with a social security system. provide signed informed consent. undergo proctologic surgery for hemorrhoids, fistulas, or anal fissures. this study seeks to explore the potential of music as a complementary method to improve postoperative outcomes.


Eligibility criteria:
inclusion criteria: * male or female, aged over 18 years. * patient who has signed an informed consent form. * patient scheduled to undergo proctological surgery (for hemorrhoids, fistula, or anal fissure) at the participating institution. * must be affiliated with a social security system or be a beneficiary of such a system. * patient must have access to the necessary technical means (smartphone, computer, tablet) to use the music care® application. exclusion criteria: * refusal to consent. * patient unable to read, write, or understand french. * vulnerable patient according to article l1121-6 of the french public health code (csp). * adult patient under guardianship or curatorship or under legal protection (safeguard of justice). * patient unable to personally give informed consent according to article l.1121-8 of the csp or an adult protected by law. * pregnant or breastfeeding women according to article l1121-5 of the csp. * patient who has already participated in a study within the last 12 months.

Keywords: standardized music therapy proctologic surgery pain management analgesic use randomized controlled trial music intervention preoperative care monocentric study