Kornimate/medical-research-clean huggingface dataset:
evaluation of metacognitive training for depression in later life (mct-silver)

Conditions: Depression

Summary: the study will evaluate the efficacy of metacognitive training for depression in later life (mct-silver) vs. cognitive remediation (mybraintraining©) in reducing depressive symptoms among older adults.

the study examines the efficacy of metacognitive training for depression in later life (mct-silver). the study intends to investigate the extent to which mct-silver leads to a significant reduction in depressive symptoms compared to an active control group (mybraintraining©) (primary outcome: change in clinician-assessed depressive symptoms from t0 to t1 and t2). secondary outcomes include change in self-reported depressive symptoms and dysfunctional (meta) cognitive beliefs, as well as quality of life, rumination, self-reported anxiety, attitudes toward aging and neuropsychological functioning from t0 to t1 and t2. the study design is a randomized-controlled trial with one intervention group and one active control group.

Eligibility criteria:
inclusion criteria: * able to give informed consent * age 60 years or older * diagnosis of a single episode or recurrent major depressive disorder (mdd) or dysthymia (verified by the mini) * sufficient command of the german language * willingness to participate in intervention over a period of 8 weeks (participants who do not attend the intervention will also be included in the analysis) * visual and auditory acuity adequate for neuropsychological testing and participation in group sessions exclusion criteria: * lifetime psychotic symptoms (i.e., hallucinations, delusions or mania) * acute suicidal tendency * intellectual disability (estimated iq \< 70) * dementia or other neurological illness
a study of clinical characteristics ,risk factors and outcome of lupus nephritis among children with systemic lupus erthromatousus in sohag univeristy hospital

Conditions: Lupus Nephritis

Summary: systemic lupus erthrematosus is an inflamatory and autoimmune condition characterized by multisystem affection and chronic course with unpredictable flares despite potentially afffecting every oragan . kidney involvment are the most common


Eligibility criteria:
inclusion criteria: - aim to include all children fulfilling diagnostic criteria exclusion criteria: * children with other rheumatological disorder neonates chidren with other nephrolgy disorder
effect of smoking on saliva composition and the development of dental erosion

Conditions: Dental Erosion

Summary: the aim of this study is to investigate whether smoking is associated with changes in salivary composition and/or predisposition to erosion. healthy volunteers are observationally wearing an intraoral device with both bovine tooth specimens (enamel and dentin) and resin specimens twice for two hours each. afterwards, specimens are eroded extraorally and calcium release into the acid is measured. total protein concentration and protein composition of the salivary pellicles on the resin samples are measured. additionally, salivary parameters (unstimulated and stimulated saliva flow rate, ph, buffer capacity, total protein content and protein composition as well as concentration of inorganic calcium, phosphate, and fluoride) are measured.


Eligibility criteria:
inclusion criteria: * volunteers aged between 20 and 50 years who are able to give written consent exclusion criteria: * non-fulfillment of the inclusion criteria * intake of medications or diseases altering salivary secretion * refusal to use fluoridated toothpastes * known allergies to substances used in the study * orthodontic treatment or malfunction which does not allow wearing an intraoral device
mindful moms in recovery

Conditions: Opioid-use Disorder

Summary: the purpose of this study is to evaluate the initial efficacy of a yoga-mindfulness intervention to promote ongoing recovery for pregnant and parenting women with opioid use disorder (oud) receiving perinatal services and medication treatment for oud from maternity care practices in new hampshire.

in this r33 project, the study team will conduct a randomized controlled trial to evaluate the efficacy and implementation of the mindful moms intervention (mmore) with a group of pregnant women with identified oud receiving medication treatment for oud at partner maternity care practices. the study team will evaluate the impact of mindful moms as an adjunct to treatment as usual on retention in medication for opioid use disorder (moud) treatment, substance use, and relapse-related risks. this study has three specific aims: aim 1: evaluate mmore in a randomized controlled study with pregnant women as an adjunct to moud treatment as usual care for impact on treatment retention, opioid abstinence, and relapse risks. aim 2: examine mechanisms of effect of mmore on outcomes. aim 3: evaluate barriers and facilitators to sustainable implementation of mmore as an adjunct to moud for pregnant and parenting women.

Eligibility criteria:
inclusion criteria: * 18 years of age or older. * english-speaking. * singleton pregnancy. * receiving comprehensive medication treatment for opioid use disorder as part of prenatal care at a partner maternity care practice. exclusion criteria: * cognitive or psychiatric impairments that prohibit being able to provide informed consent. * any physical conditions that prohibit activity such as gentle yoga.

Keywords: pregnancy mindfulness yoga substance use disorder
the effect of methylphenidate on decision-making ability of attention deficit hyperactivity disorder (adhd) adults

Conditions: Attention Deficit Hyperactivity Disorder

Summary: the aim of the study is to assess the effect of methylphenidate on cognitive performance and decision-making ability of adhd adults, and to compare this effect to the effect on healthy control adults.

two matched groups of adults - with and without adhd diagnosis - will perform a battery of computerized tasks assessing sustained attention,working-memory,non-verbal iq,and decision-making ability. in each group,half of the participants will perform the tasks after receiving a capsule containing methylphenidate (mph), and the other half will perform the tasks after receiving placebo. task performance measures will then be compared in order to assess the effect of mph on these domains.

Eligibility criteria:
inclusion criteria: * adults in the age of 21-50 exclusion criteria: * pregnant or nursing women. * people who suffer from a psychiatric disorder other than adhd which could account for their inattention symptoms better than adhd. * people who lack judgment or are unable to communicate with the experimenters. * people who are incapable of performing the computerized tasks due to sensory or motor disabilities.
agonist gonadotropin-releasing hormone (gnrh) versus antagonist gnrh

Conditions: Infertility

Summary: literature suggests that gnrh antagonists are comparatively more often used in cycles which have an unfavorable prior prognosis, and this protocol is an ideal one for poor responder patients. up to now, however not enough prospectives have been published to prove any beneficial effect of antagonists on the first cycle assisted reproductive technique. this prospective study will do to evaluate the efficacy of gonadotropin releasing hormone antagonist in comparison with the standard long protocol in the first cycle of art. the investigators will randomize 160 patients undergoing art for the first time . group 1 (n=80) was stimulate with a standard long protocol and group 2 (n=80) stimulated with gnrh antagonist and then result of art compare in two group .


Eligibility criteria:
inclusion criteria: * first cycle of art * age \< 35 years * basal fsh \< 10 iu/l exclusion criteria: * previous ivf or icsi, hyperprolactinemia, hyperthyroidism, hypothyroidism, uterine abnormality, severe endometriosis * only one ovary

Keywords: gnrh antagonist gnrh agonist pregnancy rate ovarian stimulation
study of genetic polymorphisms in thai hiv-1 infected patients on sqv/r

Conditions: HIV Infections

Summary: study of genetic polymorphisms of cyp #a and mdr-1 genes in thai hiv-1 infected patients on saquinavir/ritonavir.

genetic polymorphisms will be investigated by polymerase-chain reaction (pcr) and drug levels of saquinavir will be determined by high phase liquid chromatography with uv-detected (hplc).

Eligibility criteria:
inclusion criteria: * hiv-infected persons who have been enrolled in the staccato study * on low-dose ritonavir boosted saquinavir at the time blood samples are collected exclusion criteria: * inability to understand the nature and extent of the study and the procedures required

Keywords: genetic polymorphism cyp 3a mdr-1 thai hiv treatment experienced
increasing cessation motivation and treatment engagement among smokers in pain

Conditions: Chronic Pain; Smoking; Smoking Cessation

Summary: the goal of this study is to develop and pilot test a brief intervention to increase motivation to quit and smoking cessation treatment engagement among smokers with chronic pain.

pain and tobacco smoking are both critical national health problems, and there is mounting evidence that smokers in pain may represent an important and large subgroup who experience unique barriers and greater difficulty quitting. smoking has been identified as a risk factor in the onset and exacerbation of chronic pain, and smokers experience greater levels of pain intensity and disability, relative to non-smokers. initial evidence indicates that quitting smoking may improve pain outcomes (e.g., lower pain intensity) and supports the notion that smoking cessation may be an essential behavior change for smokers in pain. however, the vast majority of smokers are not yet ready to engage a serious quit attempt, and evidence-based treatments for smoking cessation remain dramatically underutilized. therefore, the goal of this study is to develop and pilot test a brief intervention that will address smoking in the context of pain in order to increase motivation to quit smoking and engagement of available smoking cessation treatment. participants will be randomized to either the adapted brief motivational intervention or an intervention consistent with standard clinical practice

Eligibility criteria:
inclusion criteria: * current daily cigarette smoking (at least 10/day) * current moderate-very sever chronic pain with a numerical pain rating of at least 4/10 * at least 18 years of age exclusion criteria: * current active attempt to quit smoking * enrollment in smoking cessation treatment or use of a smoking cessation medication * less than 18 years of age

Keywords: chronic pain tobacco smoking smoking cessation motivation
methylation level of shox2 in endobronchial ultrasound with real-time guided transbronchial needle aspiration for lung cancer staging

Conditions: Lung Cancer With Mediastinal Lymph Node Involvement

Summary: a dna hypermethylation of the gene locus shox2 can be frequently found in lung cancer tissue. the purpose of this study is to determine whether the assessment of the hypermethylation level of shox2 in specimens obtained by endosonographic guided bronchoscopy makes a contribution to lung cancer staging.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of lung cancer * enlarged mediastinal or hilar lymph nodes (\>10 mm) exclusion criteria: * clinical condition which excludes general anesthesia

Keywords: lung cancer ebus-tbna epigenetics shox2 protein, human
evaluation of thyroid abnormity incidence and thyroid toxicity during chemotherapy among newly diagnosed breast cancer

Conditions: Breast Cancer Female; Thyroid Gland

Summary: breast cancer is one of the most common cancers in china. even though advances in the field of breast cancer therapeutics, chemotherapy remains the mainstay therapeutic modality. the cytotoxic therapies are generally associated with some immediate or otherwise delayed side effects, such as adverse effects on gastrointestinal, hepatic, renal and hematological systems. the effect of chemotherapy on endocrine system, however, is comparatively less envisaged. several epidemiological studies show a positive association between plasma thyroid hormones levels and breast cancer risk. thyroid dysfunction is emerging as a variably common endocrine toxicity of several anticancer drugs. due to the scarcity of data on the functioning of thyroid gland during chemotherapy in a large scale group, the present study was aimed to investigate the incidence of thyroid abnormity in chinese women with newly diagnosed breast cancer, and also the effects of chemotherapy on thyroid gland functions or structure in these breast cancer patients undergoing at least four cycles of chemotherapy.


Eligibility criteria:
inclusion criteria: 1. female patients with histologically or cytologically proven primary breast cancer; 2. age \>18 years; 3. ecog performance status: 0-2; 4. life expectancy: 3 months or more; 5. no previous anti-cancer therapy; 6. be willing to undergo at least four cycles of anthracycline or taxane-based chemotherapy; 7. adequate hematological, liver, and kidney functions. exclusion criteria: 1. pregnancy or lactation; 2. history of other malignancy or secondary breast cancer; 3. history of thyroid disease; 4. history of drug addiction or abuse; 5. history of immunodeficiency disease; 6. treatment with drugs capable of influencing thyroid gland functions within 3 months prior to study entry; 7. nonmeasurable disease such as un-controlled diabetes, severe cardiovascular and cerebrovascular diseases; 8. current, recent (within 4 weeks prior to study entry), or planned participation in any other clinical trials; 9. inability to understand and agree to informed consent.
buzzy distraction during venipuncture

Conditions: Pain Relief

Summary: venipuncture is one of the most common iatrogenic painful and stressful procedures performed on children. interventions aimed at reducing the distress related to this experience are widely and strongly recommended. pain and anxiety management is even more essential because it may modify children's memory for procedural pain and the subsequent acceptance of later health care painful interventions. distraction is the most studied psychological technique to relieve venipuncture related pain and distress, with a strong evidence supporting its efficacy in children and adolescents. in recent years several studies showed the effectiveness of a specific tool named buzzy® (mmj labs, atlanta ga, usa), in relieving pain and distress in children. buzzy combines distraction and physical analgesia (vibration and cold) and it was positively tested during venipuncture, intravenous cannulation and painful injections in children. even though its efficacy it's well established, most of the published trials did not compare buzzy with other interventions, so that little data are available about its usefulness compared with other distractions techniques. hand-held computers are reusable tools, which offer a technological-based active distraction. there is evidence supporting their used during painful procedures such as venipuncture and a recent published study showed that hand-held computer distraction was as effective as nurse-led passive distraction techniques in children. the aim of this study is to compare the effectiveness of buzzy versus hand-held computer in pain relief during venipuncture.


Eligibility criteria:
inclusion criteria: * children from 4 to 12 years of age needing venipuncture exclusion criteria: * the presence of damage, denuded or broken skin in the site of buzzy application; * use of topical, enteral or parenteral analgesics within eight hours before enrolment; * the presence of cognitive impairment or the inability to report pain verbally; * the presence of chronic disease, included epilepsy, or of diseases associated with cold hypersensitivity (i.e., sickle cell anaemia, raynaud's disease).

Keywords: procedural pain phlebotomy distraction hand-held computer children
safety and risk of sensitisation of the rdesat-6 + rcfp-10 skin test following repeated intradermal administration

Conditions: Tuberculosis

Summary: the primary objective is to assess the safety of three dose levels (0.01, 0.1 and 1.0 µg) of the rdesat-6 + rcfp-10 skin test reagent when injected into healthy adults. the secondary objective is to assess the risk of sensitisation of 0.01 and 0.1 µg rdesat-6 + rcfp-10 when injected twice with time intervals of 6 or 12 weeks to healthy adults.


Eligibility criteria:
inclusion criteria: 1. has signed an informed consent 2. is willing and likely to be able to comply with the trial procedures 3. is female/male non-black adult ≥ 18 years and ≤ 55 years of age 4. is healthy according to a medical examination, medical history and laboratory investigations at inclusion 5. is prepared to grant authorized persons access to their medical records exclusion criteria: 1. has a history of tuberculosis or has had a known contact to a person with active tuberculosis 2. has a positive quantiferon-tb gold in tube test result at inclusion 3. laboratory parameters outside of normal range judged by principal investigator to be clinically significant and/or abnormal glucose or protein levels in a urine sample at inclusion 4. has been in treatment with a product which is likely to modify the immune response within 3 months prior to the day of inclusion (e.g., immunoglobulin, systemic corticosteroids, methotrexate, azathioprine, cyclosporine, infliximab or blood products) 5. has been vaccinated with a live vaccine within 6 months prior to the day of inclusion (e.g., mmr, yellow fever, or oral typhoid vaccines) 6. has a known congenital or acquired immune deficiency 7. has a disease affecting the lymphoid organs (e.g., hodgkin's disease, lymphoma, leukemia, sarcoidosis) 8. is known to be infected with hiv, hbv or hcv 9. has a severe ongoing viral or bacterial infection that might affect the cell mediated immune response at inclusion 10. has a c-reactive protein (crp) level \> 50 mg/l 11. has severe scarring, burn, rash, eczema, psoriasis, or any other skin disease at or near the injection site(s) 12. has a condition in which repeated blood drawings pose more than minimal risk for the volunteer, such as haemophilia, other coagulation disorders, or significantly impaired venous access 13. is actively participating in another clinical trial or has participated in previous clinical trials investigating the rdesat-6 skin test reagent 14. is pregnant according to urine pregnancy test at inclusion 15. is a female not willing to use contraceptives or is breastfeeding 16. has a condition which in the opinion of the investigator is not suitable for participation in the study

Keywords: tuberculosis diagnosis esat-6 cfp-10 skin test skin test for the diagnosis of tuberculosis infection
plasma protein levels and very preterm birth

Conditions: Very Preterm Infants

Summary: the primary aim of this study is to investigate the relationship between early plasma protein levels and hemodynamics in very preterm infants during postnatal transition. secondary aims are the following: i) to evaluate maternal and neonatal factors affecting plasma protein level at birth; ii) to evaluate the relationship between plasma protein level and albumin level on the first day of life; iii) to evaluate the association between early hypoproteinemia and neonatal mortality and morbidity in very preterm infants.


Eligibility criteria:
inclusion criteria: * parents written informed consent * birth at less than 32 weeks of gestational age * birth in a iii level delivery facility at reunion island exclusion criteria: * major congenital abnormalities

Keywords: preterm baby total plasma protein albumin hemodynamic disturbances perfusion near infra red spectroscopy (nirs) ultrasound
sars-cov-2, testosterone and male fragility

Conditions: COVID-19; Testosterone Deficiency; Infertility, Male

Summary: the hormonal environment (steroid, primarily) could have a very relevant pathophysiological role in association with sars-cov-2. that is, testosterone could play a relevant role in leaving male subjects more exposed to infection and more prone to developing severe complications following covid-19 infection.

preliminary data suggests that male individuals are more susceptible to covid-19 infection, at least in western countries, and that their mortality rate is higher than female individuals. this would seem to suggest that the hormonal environment (steroid, primarily) could have a very relevant pathophysiological role in association with sars-cov-2. that is, testosterone could play a relevant role in leaving male subjects more exposed to infection and more prone to developing severe complications following covid-19 infection. another option is that covid-19 infection could cause a condition of acute hypogonadism, following which, the exhaustion of androgenic action could act as a co-trigger of a severe or even fatal course of the disease.

Eligibility criteria:
inclusion criteria: patient cohort: * male patients with an age \> 18 hospitalized in the departments dedicated to the care of patients affected by covid-19 at the san raffaele hospital and with: * biological samples positive for sars-cov-2; * negative test but highly suggestive clinical and radiological picture; * patients discharged from the emergency room with biological samples positive for sars-cov-2; * ability to read and sign the informed consent control cohort: * healthy donors with an age\> 18 accessing the irccs osr blood donor center; * ability to read and sign the informed consent exclusion criteria: * people with an age \< 18; * incapacity to read and sign the informed consent