Kornimate/medical-research-clean huggingface dataset:
redistribution of fat and metabolic change in hiv infection: protocol 2 (fram fat 2)

Conditions: Human Immunodeficiency Virus

Summary: the purpose of this study is to learn whether hiv-infected patients have blood abnormalities which could lead to heart attack or stroke, and to find out what factors may contribute to these abnormalities.

this research is being done to learn whether hiv-infected patients have abnormalities in their blood vessels that could eventually lead to heart attack or stroke (atherosclerosis), in how fat is distributed in their body and in how their body handles fat and sugars. if there are abnormalities, this study will also try to find out what factors may contribute to those abnormalitites. people who participated in fram 1 may join fram 2.

Eligibility criteria:
inclusion criteria: * 18-65 years old * previous fram 1 participant * hiv positive exclusion criteria: * artificial knee or hip replacement or harrington rod * metal objects in the body.pregnancy * breastfeeding or less than 3 months after breastfeeding * weight more than 300 pound * on insulin, pancreatic enzymes, or thioridazine.

Keywords: human immunodeficiency virus fram 1
mild head trauma in the emergency room: assessment of the risk of intracranial hemorrhage in patients receving platelet inhibitors.

Conditions: Head Trauma Injury

Summary: the clinical signs presented by a patient with a mild head injury are highly variable but remain strongly predictive of brain damage. the reference examination for the diagnosis of post-traumatic intracranial hemorrhage is currently the cerebral scanner without injection of contrast medium. magnetic resonance imaging (mri) tends to surpass ct in equipped centers, except for suspected bone lesions. the time required to perform brain imaging depends on the patient's clinical condition, comorbidities and treatments. the responsibility of antiplatelet agents in post-traumatic intracranial hemorrhage is currently discussed, particularly with aspirin. the hypothesis is that there is no significant difference in the proportion of intracranial hemorrhage in patients on antiplatelet agents after mild head trauma, in the absence of other factors favoring the occurrence of intracranial hemorrhage.


Eligibility criteria:
inclusion criteria * adult patient (≥18 years old) * visit to the emergency room of the strasbourg university hospital during 2017 * victim of mild head trauma * patient who has given their consent to the reuse of their data for the purposes of this research. non-inclusion criteria * patient who expressed their opposition to participating in the study * subject under safeguard of justice * subject under guardianship or curatorship * patient on anticoagulant * non-isolated head trauma (avp, fall greater than 6 meters, etc.)

Keywords: head trauma injury head trauma traumatic intracranial hemorrhage antiaggregants, platelet
the effectiveness of skill-based hiv psychoeducation in iv-drug abuser for reducing high-risk behavior

Conditions: Addiction; Risk Reduction Behaviour

Summary: the effectiveness of skill-based hiv psychoeducation in iv-drug abuser for reducing high-risk behavior


Eligibility criteria:
inclusion criteria: age more than 18 years old dependency to opioid drugs (positive result of urin addiction test) exclusion criteria: suicide attempt not tendency for including to the study receiving treatment for addiction in recent months.

Keywords: addiction psychoeducation risk reduction behaviour drop in center (dic)
blockade of vascular potassium channels during human endotoxemia

Conditions: Endotoxemia

Summary: background: activation of no-synthase and vascular potassium (k) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine. we examined whether various k channel blockers and no-synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.


Eligibility criteria:
inclusion criteria: * healthy volunteers exclusion criteria: * drug, alcohol, nicotine abuse

Keywords: endotoxemia vascular potassium channels cytokine norepinephrine regional blood flow, inflammation, ion channels, nitric oxide synthase, pharmacology.
mri laryngeal imaging with a surface coil

Conditions: Laryngeal Neoplasms; Head and Neck Cancers; Larynx Cancer

Summary: to determine if high resolution mri can detect early invasion of cartilage by laryngeal carcinoma, and to determine if high resolution mri may be superior to conventional mri imaging or ct imaging to detect cartilage invasion.

the purpose of this study is to use a new mri imaging coil developed for enhancing structures made of cartilage to determine if the device can produce improved images of the human larynx. in addition, if enhanced images can be obtained, a further purpose will be to determine if, in patients with laryngeal cancer, whether or not early invasion of cartilage can be detected. patients with laryngeal cancer will be asked to undergone an mri scan using this new image-enhancing coil to see if cartilage invasion can be detected. patients will be followed during and after treatment to determine their ultimate response to treatment. no additional mri scans for the purposes of this protocol will be performed other than the initial pretreatment scan. we hope to determine if this new mri imaging device can detect early cancer invasion of the laryngeal cartilages in patients with laryngeal cancer. since this modality has never been attempted before on the human larynx, we are simply looking for the presence or absence of cartilage destruction. both conventional ct and conventional mri are poor at recongnizing this finding. high resolution mri may allow the detection of this finding or it may not - detection of this finding is the endpoint.

Eligibility criteria:
inclusion criteria: * patients with benign or malignant neoplasm of the larynx. * patients who have undergone prior surgery, radiation therapy, or chemotherapy for cancer of the laryngopharynx will be eligible to participate. * patients 18 years of age and older at time of evaluation, male and female, all ethnicities. * ability to understand and the willingness to sign a written informed consent document. exclusion criteria: * pregnancy * claustrophobia. * anatomic parameters which preclude scanning, such as limited range of neck motion, or inability to remain flat for at least 15 minutes. * patients with implanted devices (eg, defibrillator, pacemaker) that are a known contraindication to magnetic resonance imaging. * allergy to gadolinium contrast.
the prevalence of urinary incontinence in women and men with respiratory diseases: a questionnaire survey

Conditions: Chronic Respiratory Disease

Summary: study the prevalence of the urinary incontinence among adults with respiratory diseases.


Eligibility criteria:
inclusion criteria: * adults * patients with chronic respiratory diseases * age: 18-90 exclusion criteria: * minors * patients with cystic fibrosis * cognitive disorders * patients who do not speak french
immune tolerance induction in haemophilia a patients using wilate or nuwiq

Conditions: Hemophilia A

Summary: uncontrolled, multi-centre, non-interventional study with a prospective and a retrospective cohort, to evaluate the efficacy of wilate or nuwiq in achieving complete or partial immune tolerance induction (iti) success in severe and moderate haemophilia a patients with inhibitors


Eligibility criteria:
inclusion criteria: * male patients of any age with moderate or severe haemophilia a. * patients with a first occurrence of inhibitors, inhibitors refractory to previous iti attempt(s), or relapsed inhibitors to fviii, with an inhibitor titre of ≥0.6 bu measured on 2 separate occasions at least 2 weeks apart. * informed written consent from the patient and/or the patient's parent(s) or legal guardian(s) for patients in the prospective cohort: * patients who are currently on wilate or nuwiq iti, have just initiated iti, or are planned to initiate iti treatment with wilate or nuwiq. for patients in the retrospective cohort: * patients having received wilate or nuwiq iti before entry into this study. retrospective data will be collected for a maximum of 3 years before enrolment into the study. to be eligible, the following information is needed: * wilate or nuwiq treatment details (start date, dose, treatment frequency, and dose change). * reliably documented bleeding frequency. * fviii inhibitor titres. * fviii half-life. * fviii ivr. exclusion criteria: patients who meet any of the following criteria are not eligible for the study: * congenital or acquired bleeding disorders other than haemophilia a. * a history of hypersensitivity to blood products and/or plasma-derived fviii concentrates. * inability to speak/read english or french well enough to provide consent and adhere to the study. * people who are receiving other non-factor therapies, e.g. concizumab
fish gelatin supplement and omega-3 supplement in obese or overweight subjects with insulin resistance

Conditions: Insulin Resistance; Type 2 Diabetes

Summary: the present study was conducted to test whether a fish gelatin supplement combined with an omega-3 polyunsaturated fatty acid supplement can exert beneficial and sex-specific effects on insulin sensitivity, glucose tolerance, indicators of insulin secretion, blood pressure, lipid metabolism, inflammation and energy intake in obese or overweight insulin-resistant men and women. the investigators hypothesis is that fish gelatin improves insulin sensitivity, glucose tolerance, lipid profile and reduces inflammation in obese or overweight insulin-resistant men and women.

an important number of recent epidemiological studies have demonstrated the beneficial effects of marine omega-3 polyunsaturated fatty acids (n-3 pufa) on cardiovascular disease risk factors such as reduced triglycerides, decreased platelet aggregation, plaque stabilization, antiarrhythmic effects, and reduced blood pressure. dietary fish protein has also been shown to improve insulin sensitivity by 30% in insulin-resistant obese or overweight human subjects. in addition, an increasing number of studies describe and demonstrate the physiological and metabolic variations between men and women in regard to cvd and their risk factors, including type 2 diabetes, but the data are still limited. in agreement with the recent findings, this study was conducted to evaluate the combined and synergistic effects of omega-3 and fish protein supplements on insulin sensitivity, blood pressure, lipid metabolism and inflammation in obese or overweight insulin-resistant men and women having some or all the metabolic syndrome criteria including a deteriorated lipid profile, high blood pressure and high waist circumference in a free living situation.

Eligibility criteria:
inclusion criteria: * overweight or obese (body mass index \[bmi\] between 25 and 40kg/m2) * fasting plasma glucose below 7.0mmol/l and 2-h plasma glucose below 11.1mmol/l * fasting plasma insulin above 90pmol/l exclusion criteria: * diabetes, chronic, metabolic or acute disease * major surgery within the last 3 months * significant weight loss (±10%) within the last 6 months * any medication-taking known to affect lipid of glucose metabolism * allergy, intolerance or dislike of fish * smokers
dimensional approach to evaluate reward processing in major depressive disorder pre- and post-desvenlafaxine treatment

Conditions: Depression; Anhedonia

Summary: anhedonia (the lack of pleasure in normally pleasurable things) is a common symptom of major depressive disorder (mdd), and it may impact how patients with depression experience reward. understanding how anhedonia is related to the experience of reward may help improve how depression is treated. computer tasks can be used to measure how reward is experienced, and these measures might be able to predict things like who is likely to become depressed, or who will respond to antidepressant medication. studying the relationship between anhedonia and reward in patients with depression might also tell us something about how to improve diagnosis and treatment of other psychiatric disorders.this is an open label controlled treatment study lasting 8 weeks. the brain scans will be used to find changes in brain areas that may be related to how people perform on the tasks. the investigators goal is to use this information to help us find a reliable predictor that can be used to guide mdd treatment.


Eligibility criteria:
inclusion/exclusion criteria for mdd patients (n=40) are as follows: inclusion criteria 1. dsm-5 criteria for major depressive episode (mde) within a mdd, confirmed through mini diagnosis 2. age between 18 and 60 years 3. hamilton depression rating scale - 17 item (hrsd-17)58 \> 17 (moderate to severe symptoms) 4. free of psychotropic medications for at least 5 half-lives before baseline visit 5. ability to undergo mri scanning (absence of metal, pacemakers, etc.) exclusion criteria 1. pregnancy/lactation 2. medical condition requiring immediate investigation or treatment 3. recent (\< 6 months)/current history of drug abuse/dependence (other than caffeine, or nicotine) 4. lifetime history of psychosis, other axis i comorbidities are allowable 5. significant axis ii diagnosis 6. previous intolerance or failure to respond to an adequate trial of desvenlafaxine 7. failure of \> 2 antidepressant treatments of adequate dose and duration for current mde inclusion/exclusion criteria for healthy controls (n=20) are as follows: inclusion criteria 1. age between 18 and 60 years 2. ability to undergo mri scanning (absence of metal, pacemakers, etc.) exclusion criteria 1. pregnancy/lactation 2. medical condition requiring immediate investigation or treatment 3. lifetime history of any psychiatric disorder 4. lifetime history of receiving an antidepressant
tigr vs polypropylene (permanent) mesh: randomised trial

Conditions: Hernia

Summary: hypothesis: tigr mesh as a reconstruction material is a more effective mesh for the repair of the abdominal wall post lipectomy, transverse rectus abdominis myocutaneous (tram) / deep inferior epigastric perforator (diep) flap.

in this study we will be conducting a randomized trial to study the efficacy of tigr as a preferred reconstruction mesh for the repair of the abdominal wall post lipectomy, tram / diep flap. aims - 1. investigating the efficacy of tigr as a preferred reconstruction mesh for the repair of the abdominal wall post lipectomy, tram / diep flap. efficacy of tigr will allow us to determine the stability of the material in the abdominal wall reconstruction. 2. study the absorption characteristics of tigr implant as compared with a non absorbable polypropylene mesh. absorption characteristics can be determined by the amount of tissue ingrowth, adhesion formation and shrinkage profiles of the implant and it can be detect using ultrasound. 3. to determine whether any reactions to the implant will occur. these reaction if any will manifest as inflammation reactions which may be evident on clinical followup and can be detect by ultrasound. patients to be recruited : 80 randomized equally into the 2 groups age range: 21 - 80 all patients undergoing lipectomy, tram / diep flap reconstruction will be recruited into the study. trial duration: july 2010 - july 2015 follow up: postoperative 1 week, 1 month, 3 months, 6 months, and 12 months ultrasound will be done to determine the amount of tissue ingrowth, adhesion formation and shrinkage profiles of the implant in all these follow up appointments. complications if any can also be detected by the ultrasound.

Eligibility criteria:
inclusion criteria: * age 21 - 80 years * both male, female * all patients undergoing lipectomy, tram / diep flap reconstruction * patients with abdominal wall defects exclusion criteria: * patient refusal * infection of the abdominal / generalised infection

Keywords: abdominal wall defects inflammation reactions amount of tissue ingrowth adhesion formation shrinkage profiles of the implant
feasibility and benefit of laparoscopic hysterectomy with less than 3 millimeter diameter's instruments in current practice

Conditions: Benign Uterine Diseases

Summary: hysterectomy for benign uterine disease is often intended to young perimenopausal patients. currently laparoscopic hysterectomy is commonly used in this indication. we are wondering if decreasing the diameter of laparoscopic instruments could reduce postoperative pain and improve esthetic result without increasing operative time. the purpose of the study is to improve patients' care.

that is why we propose a randomized comparative study between standard instrument and less than 3 millimeter diameter's instruments to achieve in daily practice laparoscopic hysterectomy. the study will be unicentric, single-blind. study period will be one year and 4 months. patients will be enrolled in pre-operative consultations or at the weekly staff. they will have to sign an informed consent. the day before surgery: patients will be randomized by the statistician. a resident will carry out a preoperative ultrasound to determine an estimated uterine volume. nurses will make a blood test (hemoglobin). the day of surgery we will assess: operative time, surgeon's ergonomics, the amount of bleeding, patient's pain at rest and mobilization. at day-1 post surgery nurses will make an other blood test (hemoglobin) and we will assess patient's pain at rest and mobilization. at the postoperative consultation we will lister : complications (accordion severity score classification), esthetic result (psaq), patient's pain.

Eligibility criteria:
inclusion criteria: * patient candidate for total inter-adnexal hysterectomy or for hysterectomy with oophorectomy and * benign gynecological pathology: fibroids, adenomyosis, polyps, dysfunctional uterine bleeding. and * affiliation to social security and * informed consent exclusion criteria: * asa iii or iv patients, * age\> 80 years old, * history of major abdominal surgery by laparotomy * severe obesity (bmi\> 35kg / m2) * pathology of hemostasis and coagulation (liver disease, bleeding disorders) * uterine volume estimated on preoperative ultrasonography \> 300 g * minor patients, * adult lacking legal capacity * patients suffering from mental illness incompatible with informed consent, refusal to participate.

Keywords: mini-laparoscopy hysterectomy benign uterine diseases operative time
cost analysis of vascular surgical techniques

Conditions: Critical Limb Ischemia

Summary: whilst mortality rates and surgical limitations are widely known and understood for each intervention performed, the cost implications, in uhl, are not known. therefore, it is deemed a matter of interest to understand these costs and weigh them against the mortality rates for each intervention if available.

surgical interventions for patients with clti include endovascular revascularisation, by-pass revascularisation and amputation. clinical outcomes vary greatly for each intervention. the 5-year mortality rate for major amputations i.e., below knee (bka) and above knee (aka), is reported to range from 30% to 70%, with aka having the higher rate of mortality. concomitant type ii diabetes increases these rates of mortality for both aka and bka. whilst mortality rates are widely known and understood for each intervention performed, the cost implications, in uhl, are not known. therefore, it is deemed a matter of interest to understand these costs and weigh them against the mortality rates for each intervention.

Eligibility criteria:
inclusion criteria: 1. cases where clti was treated surgically by a vascular consultant at uhl will be included in this analysis. that being individuals who underwent revascularisation procedures and/or lower limb amputation. 2. this analysis will look at cases from a set time frame, that being 1st march 2022 to 1st march 2023. exclusion criteria: 1. cases where clti was treated conservatively/without surgical intervention will not be included. 2. surgical intervention outside of uhl. 3. cases that occurred outside of the set timeframe.
a registry of copd patients to be used for future studies

Conditions: Chronic Obstructive Lung Disease

Summary: to develop a cohort of copd participants to assist study staff in determining the most likely candidates for future studies.

to develop a cohort of copd participants for study staff to determine the most likely candidates for future studies and to develop a repository of blood from subjects with copd for future studies.

Eligibility criteria:
inclusion criteria: * patients who are 18 years of age and older who have been diagnosed with copd by at least one of the following: * clinical history-a documented history of copd, emphysema, or chronic bronchitis; * pulmonary function results (defined as an fev1/fvc less than 0.7; * radiographic results (high-resolution ct findings of emphysema exclusion criteria: * in ability to give informed consent * prisoners * pregnancy

Keywords: copd
antiseptic sutures and wound infection

Conditions: Wound Infection

Summary: the aim of this study was to ascertain if the use of vicryl plus® reduced the number of wound infections after transverse laparotomy comparing to polydioxanon suture.

all patients are treated using clinical pathways (cp) to standardise surgical procedures in our high volume centre. part of the clinical process management was the standardisation of wound incision and abdominal wall closure. wound closure is achieved by a two-layer technique using continuous absorbable loop suture. the suture length to incision length ratio is at least 4:1. the running sutures are 1 cm apart and at least 1.5 cm from the wound edge 14. in the first timeperiod (tp1), the cp step for fascia closure foresees a pds loop suture (pds ii®, 150 cm, ethicon gmbh, norderstedt, germany). after the recruitment of 400 patients, that cp step is altered to the use of a triclosan-coated polyglactin 910 loop suture (vicryl plus®, 150 cm, ethicon gmbh, norderstedt, germany). the primary outcome is the number of wound infections. patients demographic and disease as well as procedure related data are collected in a clinical information system (ishmed on sap platform, gsd, berlin, germany) prospectively. risk factors for poor wound healing, such as operation time, patients age, sex, body mass index, blood loss, peritonitis, antibiotics, and performance level classified according to the american society of anesthesiologists (asa), are collected prospectively to compare the two groups.

Eligibility criteria:
inclusion criteria: * surgical pathologies accessed via transverse abdominal incision * primary fascial closure exclusion criteria: * pregnancy * age under 18 years * open abdominal treatment * known hypersensitivity agains pds/vicryl/triclosan

Keywords: vicryl plus wound infection coated suture material open abdominal surgery transverse laparotomy