Kornimate/medical-research-clean huggingface dataset:
a pilot study in endoscopic therapy on quality of life and pain in chronic pancreatitis

Conditions: Chronic Pancreatitis

Summary: this study is a prospective study designed to assess the effect of pancreatic endotherapy on quality of life, pain levels, pancreatic exocrine function, and endocrine function.

pancreatic endotherapy represents a potential treatment modality for patients with painful chronic pancreatitis. while pancreatic endotherapy is commonly performed, the effect of chronic pancreatitis on patient-centered outcomes remains poorly studied. furthermore, the effect of endotherapy on pancreatic endocrine and exocrine are largely unknown. this study therefore aims to prospective observe patients with chronic pancreatitis after endotherapy is performed to better understand how it affects patient-centered outcomes such as pain and quality of life and pancreatic function. in doing so, the study also hopes to be able to predict which patients with chronic pancreatitis will benefit from pancreatic endotherapy.

Eligibility criteria:
inclusion criteria: * chronic pancreatitis (as defined by the american pancreatic association guidelines) * presence of pain * referred for pancreatic endotherapy exclusion criteria: * prior pancreatic endotherapy * prior pancreatic surgery * pregnant females * subjects unable to consent * imprisoned individuals

Keywords: ercp eswl quality of life quantitative sensory testing celiac plexus block pancreatic duct stricture pancreatic duct stenting pancreatic fluid collection
comparison of two methods of negative pressure wound therapy

Conditions: Acute Wounds From Trauma; Dehiscence or Surgical Complications

Summary: the current standard for negative pressure wound therapy is the vacuum assisted closure device (vac), a commercial system that utilizes a computerized suction pump to apply negative pressure to an open-cell poly-urethane foam dressing sealed over a wound. the vac system is effective but has some drawbacks: * the system is expensive. * there us conflicting data about the effectiveness of vac therapy for infected wounds. * vac therapy is difficult to use (and frequently fails) in wounds with excess fluid drainage, and in wounds near body orifices. over the past 4 years, we have accumulated additional experience with negative pressure wound therapy using wall suction applied to sealed gauze dressings with about 30 patients. we call this method g-suc and have used it when we have been unable to maintain a dressing seal with the vac system (due to excess drainage or wound location), for management if infected wounds. we have found this method to be effective without any specific negative side effects. our specific aims are: 1. compare the effectiveness of g-suc and standard vac therapy. outcomes measured for each method will include the proportional change in wound size over 1 - 2 weeks. 2. compare the effectiveness of g-suc and vac system in controlling wound infections as measured by the number of patients who are able to clear infection by 4 days. 3. compare the failure of each method of therapy by documenting the number of dressing that cannot be maintained because of fluid or suction. 4. measure and compare the cost of wound treatment with the two methods including direct cost and time spent at the bed side performing the dressing change. our hypotheses are: 1. g-suc and vac are equivalent for the treatment of uncomplicated wounds in the acute care, in-patient setting. 2. g-suc is more effective than vac for management of infected wounds. 3. g-suc is more versatile than vac, and functional g-suc dressings can be maintained in situations where functional vac dressings cannot. 4. negative pressure therapy with g-suc is less costly than vac.


Eligibility criteria:
inclusion criteria: - hospitalized patients at the university of chicago medical center with acute wounds resulting from ether trauma, dehiscence or surgical complications exclusion criteria: * patients with systemic sepsis caused by wound infection * those with grossly necrotic wounds * malignancy in the wound * wounds with untreated osteomyelitis * patients with allergy to sulfamylon and dakin's (sodium hypochlorite) patients with 2 first criteria would become eligible once their sepsis resolves and/or necrotic tissue has been debrided from the wound.
two-stent vs provisional stenting techniques for patients with complex coronary bifurcation lesions

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to establish the optimal strategy for stenting in coronary bifurcation lesion.

the current study is designed as a multicenter, randomized and prospective study aiming to compare the effect of two-stenting and simple stenting techniques in patients with complex bifurcation lesions. based on the previous studies, the rate of 1-year target lesion failure events was around 14% after pci with provisional stenting. and our previous data showed that this event at 12-month after two-stenting procedure was 7%. considering the lost to follow-up, it is anticipated that up to 660 patients will be enrolled in the trial. all patients will have repeat angiography at 13 months, with clinical follow-up to 5 years.

Eligibility criteria:
inclusion criteria: * provision of informed consent prior to any study specific procedures; * men and women 18 years and older;. * established indication to pci according to the guidelines of american heart association and american college of cardiology; * native coronary lesion suitable for drug-eluting stent placement; * true bifurcation lesions (medina 0,1,1/1,1,1); * reference vessel diameter in side branch ≥2.5mm by visual estimation; * complex bifurcation lesions based on definition study. exclusion criteria: * pregnancy and breast feeding mother; * co-morbidity with an estimated life expectancy of \< 50 % at 12 months; * scheduled major surgery in the next 12 months; * inability to follow the protocol and comply with follow-up requirements or any other reason that the investigator feels would place the patient at increased risk; * unable to provide written informed consent, or fail to follow the protocol; * previous enrolment in coronary intervention device investigation during the study period; * patient with stemi within 24-hour from the onset of chest pain to admission; * restenosis bifurcation lesions.

Keywords: bifurcation lesion percutaneous coronary intervention
individualized prophylaxis for severe hemophilia a children

Conditions: Hemophilia

Summary: a multi centre two year long term escalating dose tertiary prophylaxis study on the efficacy and cost saving of individualized low dose prophylaxis regimens for boys with severe hemophilia a in china staring with a low dose regimen in step i, an escalated low dose regimen in step ii and a tailored dose regimen based on individual pk profiles in step iii. the dose escalation criteria are adjusted according to patterns and frequencies of joint bleeding and assessed in each subject every 3 months. efficacy of the 3 different dose regimens are measured by the annualized joint bleeding rate (ajbr) as a primary end point and the hemophilia joint health score (hjhs ) and qol scores (cho-klat and pedsqol) , image studies of target joints by ultrasound, x-ray and mri examinations, consumption of factor viii and inhibitor rates as secondary end points.


Eligibility criteria:
inclusion criteria: 1. severe hemophilia a with fviii \<1 % 2. age from 6 to 10 years 3. patients with more than 50 exposure day (ed) 4. patients with one or more target joints (a target joint is defined as a joint with 3 or more bleeds in a consecutive 3 months) or disease joints (defined as presence of visible joint swelling and /or limitation of movements and/or joint deformities in the absent of an acute joint bleed ) 5. on-demand treatment more than 12months before the study exclusion criteria: 1. a history of fviii inhibitor (titer greater than 0.6 bu) and detectable fviii inhibitor at screening (titer greater than 0.6 bu) 2. chronic renal failure (serum creatinine greater than 2.0 mg /dl) 3. chronic liver disease (alt greater than 200 u/l)) 4. patients with clinically documented immunodeficiencies 5. patients anticipated to require major surgery 6. patients with competing high risks such as symptomatic hiv infection, juvenile rheumatoid arthritis, metabolic bone diseases, or other diseases known to mimic or cause joint diseases 7. patients live too far from the comprehensive care centre at bch and had demonstrated previous non compliance to therapies or clinical studies
the relationship between aortic pulse wave and peripheral artery occlusion disease in hemodialysis patients

Conditions: End-stage Renal Disease; Hemodialysis; Aortic Calcification; Peripheral Artery Occlusion; Cardiovascular Disease

Summary: cardiovascular disease (cvd) is the leading cause of mortality in patients with end-stage renal disease (esrd), which means that it is important to find out risk factors of cvd in order to prevent or treat it. in recent years, there has been more and more recognition of a very high prevalence of cv calcification in the esrd population. many observational cohort studies have shown that cv calcification in these patients can predict mortality, cv mortality and morbidity. electrolyte imbalance is easily found in the esrd patients which may result in vessel calcification. calcification leads to arterial stenosis and increasing arterial stiffness and then heart afterload, both contribute to the development of cvd. besides, metabolic syndrome, insulin resistance, and dyslipidemia pave the way for a chronic, immune-mediated vascular inflammation and cardiovascular disease. these factors are prevalent in esrd patients, which would also cause arterial stiffness. arterial stiffness and stenosis would increase the risk of cv events and mortality. aortic pulse wave velocity is strongly associated with the presence and extent of atherosclerosis and constitutes a forceful marker and predictor of cardiovascular risk. at the same time, high prevalence of peripheral artery occlusion disease (paod) should also be found while arterial stiffness and stenosis, which would increase the condition of infection and gangrene. thus, life safety and quality would be influenced severely and early detection might prevent future amputation. uremic patients also have a higher risk for metabolic syndrome. therefore, more studies to evaluate the condition of arterial stiffness and paod, especially in hd patients, are needed for future management and preventions of cv related morbidity and mortality.


Eligibility criteria:
inclusion criteria: 1. patients at national taiwan university hospital (ntuh) 2. patients who have received hd more than 3 months 3. patients who sign the informed consents exclusion criteria: 1. patients who refuse to sign informed consents 2. patients who refuse to draw additional blood for research

Keywords: calcification aortic pulse wave velocity peripheral artery occlusion disease hemodialysis metabolic syndrome
a low chloride hypertonic solution for brain edema

Conditions: Subarachnoid Hemorrhage; Acute Kidney Injury

Summary: this pilot study will compare the two hypertonic solutions currently used for subarachnoid hemorrhage (sah) - related complications and to determine if the reduction of chloride load is safer, and as efficacious as the classic hypertonic solution.

this pilot study aimed to collect high-quality randomized and prospective information to help plan a future, larger multicenter trial. the study will compare the two hypertonic solutions currently used for subarachnoid hemorrhage (sah) - related complications and to determine if the reduction of chloride load by using a sodium acetate and sodium chloride mixture can lead to a relative reduction of serum chloride, reduce kidney injury, and as efficacious as the classic hypertonic solution. hyperosmolar therapy is one of the mainstay treatments for sah-related cerebral edema and vasospasm, in order to reduce delayed cerebral ischemia. recent evidence from the literature correlates high chloride load when applying iv fluids with worse outcome in a variety of critically-ill patients. hypertonic saline, with which most hyperosmolar treatment is done, contains a supra-physiologic chloride load. it is possible that by changing the hypertonic solution to a "chloride-lean" one, the study team would be able to reduce the side effects of hypertonic sodium-chloride without losing its efficacy in treating sah-related complications.

Eligibility criteria:
inclusion criteria: * spontaneous sah with an identified aneurysmal source as identified on neuroimaging obtained at admission to emory university hospital or with imaging at an outside hospital * age ≥ 18 years exclusion criteria: * sah related to non-aneurysmal vascular anomaly * sah thought due to trauma * sah occurring in relation to another medical procedure (cardiac catheterization, lvad placement, etc.) * sah with a negative workup for cause ("angio-negative") * patients who arrive in a brain-death state or in a devastating clinical status that will be presumed to lead to brain death or early withdrawal of treatment * patient who suffer from end-stage renal disease at baseline and who are routinely treated with dialysis * known pregnancy

Keywords: osmolar therapy acetate
effectiveness of cannabidiol vs. narcotics for post operative pain control in elective shoulder arthroscopic surgery

Conditions: Post-operative Pain

Summary: this study is a prospective, randomized, nonblinded trial to evaluate the effectiveness of cannabidiol (cbd) oil on post-operative pain control compared to opioid medications.


Eligibility criteria:
inclusion criteria: * age 18 years or older * requiring shoulder arthroscopic surgery for soft tissue pathology * able to complete surveys and follow-up visits exclusion criteria: * younger than 18 years of age * shoulder dislocation, fracture, previous surgery, coexisting extremity pathology, pregnancy.
foot positions affect knee and ankle proprioception, balance, vertical jump, and muscle activity in individuals with flexible and rigid flatfoot and chronic ankle instability

Conditions: Flatfoot

Summary: to investigate the effect of various foot positions affect knee and ankle proprioception, balance, vertical jump, and muscle activity in individuals with flexible and rigid flatfoot and chronic ankle instability


Eligibility criteria:
inclusion criteria: * the inclusion criteria were the presence of ff and chronic ankle instability in the dominant foot. flexible and rigid flat feet were initially diagnosed by an orthopedist using a weight-bearing position with a standardized radiograph technique. the digital x-ray detector (film) and the x-ray tube (source) are 35-40 inches apart in lateral views of the foot. then, jack's test was performed to differentiate between the flexible and rigid ff. jack's test is a valid test in assessing ff 10. finally, people with flexible a second degree ff (meary's angle between 15° to 30°) 3 were included in this study. the degree of flatfoot was determined by measuring the talus-first metatarsal angle on a lateral weight-bearing radiograph. this angle lies between a line drawn from the centers of the longitudinal axes of the talus and the first metatarsal. an angle that is greater than 4° convex downward is considered pes planus with an angle of 15° - 30° considered moderate, and greater than 30° severe 8. chronic ankle instability was defined as the subject had a minimum of 2 acute ankle sprains, in the last 6 months, associated with pain, swelling, and a record of various ankle giving way. the determination of the dominant foot followed vauhnik. \& ark, modified version which stated that the dominant foot should be used minimally in 2 of the 3 subsequent activities: (1) using the leg to step over a spider toy, (2) drawing a diamond figure on the ground and (3) kicking a ball. exclusion criteria: * the exclusion criteria were the existence of limited hallux dorsiflexion because jack's test is valid only if hallux dorsiflexion is available during relaxed standing. also, the participants were excluded if they had previous hip, pelvis, knee, or foot surgeries within the last year; obesity or pregnancy; leg-length discrepancies; has any vestibular disorder neurological disorder, brain concussion within the last 3 months that may cause balance impairment; or administering any drugs that could disturb alertness or balance.
single-dose study of anx007 in participants with primary open-angle glaucoma

Conditions: Open-angle Glaucoma

Summary: this is a multi center, open-label, single dose, safety study. approximately 9 to 15 participants with open-angle glaucoma are assigned into 3 sequential dose-levels and will receive anx007 administered as single, ivt injections.

this is a phase 1, open-label, dose-escalation, safety study evaluating up to 3 dose levels of anx007 administered as single ivt injections. approximately 9 to 15 eligible participants are enrolled into one cohort each. all participants receive anx007 in an open-label manner. the primary objective is to evaluate the safety and tolerability of a single intravitreal (ivt) injection of anx007 in participants with primary open-angle glaucoma. secondary objectives are to evaluate the serum pharmacokinetics (pk) and immunogenicity. an exploratory objective will evaluate the pharmacodynamic (pd) effect of anx007 on serum c1q activity.

Eligibility criteria:
inclusion criteria: * male or female age 18 years and older * diagnosis of primary open-angle glaucoma * intraocular pressure \<21 mm hg on a stable iop treatment regimen * reliable visual field testing exclusion criteria: * bcva worse than 20/80 in either eye * extensive glaucomatous visual-field damage * history of intraocular inflammatory or infectious eye disease in study eye * ocular trauma in study eye within the preceding 6 months * history of uncomplicated cataract surgery less than 6 mos prior * any abnormality preventing reliable tonopen tonometry in study eye * active malignancy within past 5 yrs * previous tx with another humanized monoclonal antibody * history of any autoimmune or neurologic disease * concurrent use of glucocorticoid medications * receiving monoamine oxidase inhibitor therapy
prophylactic antibiotics useful with antibiotic impregnated external ventricular drains (evds)?

Conditions: Subarachnoid Hemorrhage; Intracerebral Hemorrhage; Ventriculitis, Cerebral; Hydrocephalus

Summary: the length of prophylactic antibiotic use with antibiotic impregnated external ventricular drains (evd)s is unknown. this study is a randomized clinical trial with two arms: 1. twenty four hours of prophylactic antibiotic use or 2. prophylactic antibiotic use for entire duration of evd

the principle objective of this study is to compare the incidence of ventriculostomy related infections (vris) in patients who receive twenty-four hours of antibiotics, beginning no more than sixty minutes prior to evd placement, to the incidence of vris in patients who also receive a pre-procedural dose of antibiotics with continued dosing of antibiotics for the duration of the external ventricular drain (evd).

Eligibility criteria:
inclusion criteria: * patients over the age of 18 years and patients diagnosed with a subarachnoid hemorrhage, intracerebral hemorrhage or acute ischemic stroke who require an evd for management of their underlying condition. * in certain cases (a small minority), an evd must be replaced due to failure (i.e.; blood clot interrupting flow). in such cases, patients will be re-dosed with antibiotics prior to catheter exchange in typical fashion, and continue in their previously randomized treatment group. exclusion criteria: * patients who underwent any intracranial procedure in the 30 days prior, * patients who were on antibiotics within the week prior to admission, * patients with leukopenia (\<5000) at baseline, * patients with signs of meningitis, ventriculitis or any other infection at presentation, * patients who are pregnant or prisoners. * patients aged \< 18 years old

Keywords: subarachnoid hemorrhage intracerebral hemorrhage ventriculitis hydrocephalus
advanced magnetic resonance imaging for perioperative evaluation of dental, oral and maxillofacial trauma

Conditions: Traumatology; Maxillofacial Trauma; Maxillofacial Injuries

Summary: dental, oral, and maxillofacial trauma represents a significant public health concern, with most cases resulting from accidents and occurring frequently in young adults. diagnosis relies on clinical examination and imaging modalities like computed tomography (ct) and cone-beam computed tomography (cbct), which are standard for hard tissue assessment but expose patients to ionizing radiation. to reduce radiation exposure while simultaneously allowing for the visualization of soft tissues, newer imaging methods, including magnetic resonance imaging (mri), as well as black bone and ct-like mri protocols (zte, ute), are being explored. these mri techniques offer high-resolution, non-ionizing alternatives, showing promise for diagnosing soft tissue injuries and fractures without radiation risks, especially beneficial for younger patients. this study aims to assess mri's diagnostic capabilities for maxillofacial trauma, focusing on early diagnosis, artifact reduction, and comparison to conventional x-ray-based imaging, within a minimal-risk study framework. this study aims to evaluate the diagnostic efficacy of mri compared to x-ray-based imaging modalities (ct/cbct) for detecting dental, oral, and maxillofacial fractures, with a specific focus on black bone and ct-like mri techniques. additionally, it investigates mri's potential to reduce artifacts around osteosynthesis plates, enhancing postoperative imaging quality in the presence of metal hardware.


Eligibility criteria:
inclusion criteria: * patients presenting with acute dental, oral and maxillofacial trauma * age: 18 years and older * able to give informed consent (documented by signature) * no prior radiation-based imaging for the current trauma episode exclusion criteria: * pregnant or lactating individuals * known contraindications to mri (e.g., pacemakers, certain implants) * clinically significant concomitant diseases affecting imaging quality (e.g., severe neurocognitive disorders) * inability to comply with mri procedures or study protocol (e.g., due to language barriers, psychological disorders, or dementia) * participation in other clinical trials that may interfere with the imaging study