Kornimate/medical-research-clean huggingface dataset:
assessment of muscle strength and volume changes in patients with breast cancer- related lymphedema

Conditions: Lymphedema Arm; Lymphedema; Surgical

Summary: this study aims to find whether complete decongestive therapy used in breast cancer-related lymphedema has an effect on muscle strength in the affected arm, while assessing the efficacy of the therapy itself. 74 patients with breast cancer related lymphedema were included in this study. patients were taken their demographic and clinical history and were evaluated with measurements of extremity volumes and hand grip strengths using a hand dynamometer before and after the complete decongestive therapy. data were then assessed using relevant statistical methods.


Eligibility criteria:
inclusion criteria: * having had mastectomy or breast conserving surgery * having a certain diagnosis of lymphedema with a difference in arm circumferences more than 1 cm exclusion criteria: * the subjects with active infection or cancer with metastases, the ones who didn't accept the complete decongestive therapy, patients with vascular disease, rheumatic disease, upper limb deformity, any upper limb surgery history, bilateral lymphedema or a history of transplantation were excluded

Keywords: lymphedema hand grip strength breast cancer related lymphedema complete decongestion therapy
chronic obstructive pulmonary disease (copd) maintenance treatment patterns in china

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: this observational study will be conducted in copd participants in tier 2 and 3 hospitals in china to gain an understanding of the complex copd management and physician's treatment strategy.


Eligibility criteria:
inclusion criteria: * male or female participants with minimum 40 years of age. * a diagnosis of copd confirmed by spirometry (according to global initiative for chronic obstructive lung disease \[gold\] 2019 criteria) in tier 2 and tier 3 hospitals. * in hospitalized participants, recruit only participants who receive any intravenous therapy. * a signed and dated written informed consent. * participants can communicate normally. exclusion criteria: * current primary diagnosis of asthma, active tuberculosis, bronchiectasis, lung cancer or other active pulmonary disease. * other unstable diseases or cognitive behavior, which could influence cat and lung function results (judged by physicians). * experienced a moderate/severe copd exacerbation treated by a physician within last 1 month. * currently participating in another copd clinical study, which provides the participant investigational medication and/or disease management.

Keywords: chronic obstructive pulmonary disease china disease burden maintenance treatment patterns
effect of aerobic and resisted exercise on lipid profile and quality of life in overweight breastfeeding women

Conditions: Postpartum Weight Retention

Summary: the aim of the study was to investigate the effect of aerobic and resisted exercise program on lipid profile and quality of life in overweight breastfeeding women.

although previous studies reported that exercise training during the postpartum period could improve the lipid profile and quality of life in overweight women and reduce the postpartum fatigue . none of them had investigated the effect of aerobic and resisted exercises on lipid profile and quality of life in overweight breastfeeding women.this trial will include 2 groups: group (a): was consist of 27 overweight breastfeeding women, who received nutritional recommendation and faradic current stimulation for 20 min on abdominal surface 2 times per week for 12 weeks. group (b): was consist of 27 overweight breastfeeding women, who received the same nutritional recommendation and faradic current stimulation for 20 min on abdominal surface 2 times per week plus exercise training (aerobic + resisted) for 12 weeks.

Eligibility criteria:
inclusion criteria: 1. all of women were sedentary, non-smoking, breastfeeding women at their 3rd to 6th months postpartum 2. they had delivered a single, healthy, mature fetus with no complications through normal vaginal delivery. 3. their age was ranged from 20 to 30 years old. 4. their parity number was one or two. 5. they were overweight (body mass index (bmi) was ranged from 25 to 30 kg/m²). exclusion criteria: 1. having chronic disorders, heart disease, respiratory infections, diabetes mellitus, pelvic abnormalities, hormonal abnormalities, psychological problems, menstrual disorders or anemia of other pathological origins. 2. receiving any type of physical exercise or sport. 3. following a specific diet program.

Keywords: exercise breastfeeding overweight lipid life quality
evaluating primary suicide prevention in adolescents with risk factors

Conditions: Suicide Prevention

Summary: suicide is one of the main causes of death among teenagers. because it is preventable, primary prevention of suicide has become a public health priority, with encouraging results in promoting suicide awareness and reducing suicidal thoughts among adolescents. however, the lack of studies conducted among vulnerable populations (i.e., marginalised, disengaged and disadvantaged) is a major gap, even though these populations present an increased risk of suicidal behaviour. the aim of this project is to test the effectiveness of a brief primary suicide prevention intervention for vulnerable adolescents, using a randomised controlled trial. vulnerable adolescents include those 1) detained in juvenile detention centres, 2) at risk of dropping out of school, 3) undergoing treatment for psychiatric disorders, and 4) belonging to a sexual or gender minority. the main aim is to test the effectiveness of the intervention on a composite measure of suicide awareness, psychological distress and suicidal thoughts. the project will also explore other issues that present challenges for vulnerable populations: access to primary suicide prevention and non-response bias. the study will provide relevant results to address the current lack of high-quality evidence for primary suicide prevention in adolescents.


Eligibility criteria:
inclusion criteria: * vulnerable adolescents defined as being: 1) detained in juvenile detention centers, 2) disconnected from school, 3) in treatment for psychiatric disorders, or 4) belonging to a sexual or gender minority. * age 14 to 18 years old. * good knowledge of french. * accepting to sign the informed consent. exclusion criteria: * the medical/educational staff considers that the intervention will interfere with appropriate management of acute psychiatric disorder or may cause harm to self or other. * being enrolled in another suicide prevention intervention during the study period.

Keywords: suicide primary prevention vulnerable adolescents psychological distress
study of fk778 in renal transplant recipients with untreated bk nephropathy

Conditions: BK Polyomavirus; Kidney Diseases

Summary: the purpose of this study is to assess the safety and effectiveness of a new oral immunosuppressant agent compared to standard care in renal transplant patients diagnosed with bk nephropathy.

the purpose of this study is to assess the efficacy and safety of fk778 compared with standard care in renal transplant recipients with newly diagnosed and untreated bk nephropathy.

Eligibility criteria:
inclusion criteria: * renal transplant recipient with newly diagnosed bk nephropathy. exclusion criteria: * previous treatment for bk nephropathy * organ transplant other than kidney * uncontrolled concomitant infection other than bk nephropathy

Keywords: investigational therapies treatment effectiveness treatment efficacy immunosuppressant bk nephropathy polyomavirus, bk human polyomavirus bk polyomavirus hominis 1
efficacy and safety of balloon guide catheter in mechanical thrombectomy patients

Conditions: Mechanical Thrombectomy; Stroke; Balloon Guide Catheter

Summary: with mechanical thrombectomy now representing standard of care for treatment of acute ischemic stroke secondary to large vessel occlusion, identifying adjunctive techniques that result in improved outcomes for patients with lvo has become an issue of increasing importance. a number of retrospective studies have demonstrated that flow arrest during the clot retrieval process results in less clot fragmentation, lower rates of distal emboli, higher revascularization rates and improved rates of good neurological outcome.


Eligibility criteria:
inclusion criteria: * age 18 years or older * a clinical diagnosis of acute stroke, with a deficit on the nihss of 2 points or more. * intracranial arterial occlusion of the distal intracranial carotid artery or middle (m1/m2) or anterior (a1/a2) cerebral artery, demonstrated with cta, mra, or dsa. * treatment can be initiated (groin puncture) within 6 hours of symptom onset. * planning to mechanical thrombectomy with a stenting retriever. * signed informed consent prior to entering study. exclusion criteria: * moderate stenosis, severe stenosis, or occlusion of the ipsilateral extracranial carotid artery. * previously deployed stents in the ipsilateral carotid artery. * dissections of the ipsilateral carotid artery. * known hemorrhagic diathesis, coagulation factor deficiency, or oral anticoagulant therapy with inr \> 3.0. * baseline platelet count \< 50.000/µl. * baseline blood glucose of \ 400mg/dl. * severe, sustained hypertension (sbp \> 220 mm hg or dbp \> 110 mm hg). * renal insufficiency with creatinine ≥ 3 mg/dl. * patients in sedation and intubated patients could not be included if baseline nihss is not obtained by a neurologist or emergency physician prior to sedation or intubation. * seizures at stroke onset which would preclude obtaining a baseline nihss. * unlikely to be available for 90 days follow-up (e.g. no fixed home address, visitor from overseas). * subject participating in a study involving an investigational drug or device that would impact this study.
acetabular labral tear in dysplastic hips

Conditions: Developmental Dysplasia of the Hip; Labrum

Summary: a prospective case-control study of the clinical and radiographic outcome of periacetabular osteotomy in patients with and without preoperative acetabular labral tears.


Eligibility criteria:
inclusion criteria: * developmental dysplasia of the hip exclusion criteria: * contraindication for magnetic resonance arthrography * severe deformities of the femural head
evaluation of direct transfer to angiography suite vs. computed tomography suite in endovascular treatment: randomized clinical trial (angiocat)

Conditions: Stroke, Acute

Summary: to evaluate the hypothesis that an ultra-fast triage with one-stop in angiography suite based on cone-beam ct compared to traditional protocol offers a better outcome in the distribution of the modified rankin scale scores at 90 days in acute ischemic stroke patients with suspected large vessel occlusion (lvo) within 6 hours from symptoms onset.

prospective, randomized, open, treatment-blinded trial of acute stroke patients with suspected large vessel occlusion within 6 hours from symptoms onset in which two strategies will be compared: direct transfer to angiography suite (dtas) vs. computed tomography suite (dtct). the study will be unicentric however there is the possibility of incorporating new stroke centers with previous experience of at least 50 dtas cases. the race scale (rapid arterial occlusion evaluation) will be used as a prehospital screening tool to identify acute stroke patients with suspicion of lvo. once prenotifying the imminent arrival and the verified inclusion and exclusion criteria by the neurologist at arrival, the patient will be randomized by an app in one of both study protocols. subjects will be followed up to 90 days post-randomization.

Eligibility criteria:
inclusion criteria: * large vessel occlusion suspected acute stroke codes (race\>4) within 6 hours from stroke onset which are prenotified from emergency medical system. * confirmed nihss\>10 at arrival. * good pre-stroke functional status (mrs≤2) * angiography suite available. * endovascular treatment team available (neurologist, interventionist, anesthesiologist, nursery, technicians...) exclusion criteria: * hemodynamically unstable patients who requires of advanced vital support. * patients with an advanced disease that conditions a life expectancy lower than 6 months. * participation in other clinical trial with a drug or device which could influence in the outcome. * patients with neurological or psychiatric disease that could confound future evaluations. * lack of disponibility for 90 days tracing.

Keywords: endovascular treatment large vessel occlusion
impact of bevel orientation on arteriovenous fistula puncture in hemodialysis

Conditions: End-Stage Renal Disease Requiring Haemodialysis

Summary: end-stage renal disease (esrd) is a condition in which the filtration function of the kidneys has deteriorated, necessitating dialysis or transplantation. with an aging population, the number of patients undergoing dialysis for ckd is constantly increasing. there are different types of dialysis treatment: hemodialysis and peritoneal dialysis. hemodialysis involves exchanges between blood and a dialysate (a liquid used to purify blood) via a dialyzer (artificial filter), coordinated by a generator. this method requires a vascular approach, of which there are 3 types: the arteriovenous fistula (avf), the arteriovenous graft and the central venous catheter. the avf remains the vascular access of choice for hemodialysis sessions, and its preservation is an essential objective for patients with ckd. one of the major challenges for avfs is to achieve a successful puncture, an act performed around 310 times a year per patient, for dialysis performed three times a week with double needles. this repeated procedure can cause damage to the avf, leading to complications such as stenosis, thrombosis, aneurysm, superficial infection, hematoma, bleeding, parietal rupture or dissection. however, there is no official recommendation on the most conservative puncture technique for avf. in view of the number of patients concerned and the recurrence of puncture, it would seem essential to evaluate the impact of bevel orientation on the occurrence of complications during dialysis by means of a randomized prospective study.


Eligibility criteria:
inclusion criteria: * male or female with chronic kidney disease * patient requiring 4-hour hemodialysis sessions, 3 times per week, in a dialysis center * native arteriovenous fistula (avf) (without prosthesis), mature, with no prior puncture, located in the upper limb * first fistula for a hemodialysis patient * expected duration of dialysis ≥ 1 year * double-needle dialysis * hemodialysis possible on avf * average avf flow rate between 500 and 2,000 ml/min * affiliated with a social security scheme * free and informed consent exclusion criteria: * auto-dialysis at home * puncture using the buttonhole technique * patient requiring avf puncture with a catheter * planned transplant within the next 12 months * previous avf creation, except for the fistula of interest * patient with a history of cancer within the past 5 years or active cancer * patient under court protection or guardianship * pregnant and breast-feeding women * patient with psychiatric pathologies or cognitive disorders * patient follow-up difficult or impossible for geographical or other reasons, at the investigator's discretion

Keywords: arteriovenous fistula puncture technique vascular approach
factors related to the progression of non-target coronary lesions

Conditions: Coronary Stenosis

Summary: the goal of this observational study is to learn about correlation between traditional risk factors and emerging risk factors on the progression of non-target coronary lesions in patients with non-target lesions on at least two coronary angiographies at the first affiliated hospital of shandong first medical university. the main question it aims to answer is what the correlation between emerging risk factors and progression of coronary non-target lesions, and try to explore the powerful predictors of progression of coronary non-target lesions and cardiovascular events. participants will be divided into two groups based on coronary angiography results: 1. progress group:there is at least one major coronary artery (left main artery, left anterior descending artery, left circumflex artery or the right coronary artery) had non-target lesions, and the coronary artery stenosis rate reached the progressive level on follow-up angiography. 2. non-progress groups: on repeat angiography, the rate of coronary stenosis did not reach progressive levels.

the laboratory and auxiliary examination indexes of the study participants were collected prior to two coronary angiography (cag) procedures, encompassing blood cell counts, glucose metabolism, lipid metabolism, renal function, cardiac function, inflammatory factors, etc. quantitative flow fraction (qfr) was employed for assigning values to coronary artery images and analyzing lesion information (including plaque progression and non-progression). the correlation between conventional risk factors, lipoprotein(a), homocysteine, and other emerging risk factors with the progression of non-target coronary lesions was analyzed; furthermore, the predictive value of emerging risk factors for non-target coronary lesion progression was evaluated.

Eligibility criteria:
inclusion criteria: 1. age \> 18 years old; 2. participants underwent at least two coronary angiography examinations in our hospital, and the time interval between the two angiography examinations was ≥12 months; 3. at the first angiography, there is 20% to 70% stenosis in the coronary artery lesion, and no indication or condition for intervention. exclusion criteria: 1. participants had a documented medical history of various heart diseases, including congenital heart disease, pulmonary heart disease, valvular disease, cardiomyopathy, etc. 2. angiography or serum collection was conducted within 7 days following the onset of acute myocardial infarction. 3. exclusion criteria included uncontrolled severe arrhythmia and severe hepatic and renal dysfunction. 4. patients with tumor or other autoimmune diseases were excluded from the study. 5. incomplete clinical information, biochemical test information, coronary angiography data, and imaging data were considered as exclusion factors.

Keywords: coronary heart disease atherosclerotic progression non-target coronary lesion quantitative flow ratio
effect of gaba supplementation in the progression of type 1 diabetes in children

Conditions: Diabetes Mellitus

Summary: type 1 diabetes mellitus (t1dm) is an autoimmune disease in which the body's immune system attacks and destroys the insulin producing beta cells of the pancreas. this condition is very prevalent, affecting up to 1:400/500 persons worldwide. type 1 diabetes, previously known as juvenile diabetes, usually strikes in childhood, adolescence, or young adulthood, but lasts for a lifetime. to date, there have been no treatments that can arrest or reverse the ongoing beta cell destruction. the patients affected by this disease require multiple daily insulin injections to manage their blood sugars and usually have trouble regulating their blood sugars. moreover, they are at risk for heart disease, kidney failure, eye problems, and other complications from this life-long condition. the investigators plan to utilize gamma-amino butyric acid (gaba) in children with newly diagnosed t1dm. this neurotransmitter is made in the brain from the amino acid glutamate with the aid of vitamin b6. there have been some recent studies in diabetic mice utilizing gaba to reverse inflammation on the pancreas and improve hyperglycemia. gaba studied in healthy human subjects demonstrated that large oral doses of gaba increased insulin secretion from the pancreas. the investigators propose that gaba given to children with new onset t1dm will be able to increase insulin production, suppress glucagon release, and decrease the inflammation surrounding the pancreas. the investigators hope this will at least prolong the beta cell life after diagnosis, if not lead to a cure for type 1 diabetes.


Eligibility criteria:
inclusion criteria: * positive for any of the 3 measured antibodies gad-65, ica-512, or islet cell * must meet the ada criteria for diabetes diagnosis * within 12 weeks of diagnosis of dmi at enrollment * peak stimulated c peptide of \> 0.2 ng/ml with mixed meal tolerance test * if post-menarchal they must use 2 forms of contraception during the study: this may include ocps, abstinence and barrier methods. abstinence will be accepted as a single method if used prior to enrollment. exclusion criteria: * chronic systemic use of steroids * pregnancy or breastfeeding * seizure disorder * current use of baclofen, valium, acamprosate, neurontin, or lyrica * history of alcoholism/alcohol use * current use of anti diabetes drugs other than insulin * diagnosis of hemoglobinopathy * diagnosis of liver disease, cancer, cystic fibrosis, or renal failure

Keywords: diabetes mellitus children
ehr-based patient identification and panel management of patients with iron deficiency anemia

Conditions: Iron-deficiency Anemia

Summary: the objective is to determine if a set of clinical supports that includes computer-assisted identification, an ehr registry, facilitated gi referral, and an ehr tool for documentation improves the timely referral and completion of bidirectional endoscopy in men aged 18 years and older and women aged 40 years and older with iron deficiency anemia.


Eligibility criteria:
inclusion criteria: northwestern medical group primary care physician (internal medicine, family medicine or geriatrics) exclusion criteria: no primary care office practice within northwestern medical group
effect of pcsk9 inhibitor on retinal microvessels in patients with coronary heart disease after intensive lipid-lowering therapy

Conditions: Adverse Effect of Cardiovascular Medications (Diagnosis)

Summary: in patients with coronary heart disease who were treated with pcsk9 inhibitor evolocumab for intensive lipid-lowering therapy, the changes of retinal microvessels were measured with octa (optical coherence tomography angiography)before and after the treatment. the specific indicators included retinal microvessel diameter, macular area，optic disc vascular density and faz(foveal avascular zone)area, etc., to clarify the effect of evolocumab on retinal microvessels after intensive lipid-lowering therapy.


Eligibility criteria:
inclusion criteria: 1. age 50-75 years old, gender unlimited; 2. diagnosed as coronary atherosclerotic heart disease 3. the informed consent for the study has been signed exclusion criteria: 1. those who are unable to cooperate with the examination; 2. poor imaging quality of refractive interstitial opacity; 3. macular edema or complicated with macular membrane and senile macular degeneration; 4. have a history of previous fundus surgery; 5. those with eye diseases that can cause changes in the microvessels of the fundus; 6. abnormal elevated intraocular pressure; 7. moderate or above refractive error (≥ ± 3 diopters) 8. people with cognitive impairment, material dependence, and serious mental illness; 9. those who do not cooperate with follow-up; 10. those who participate in other clinical trials at the same time