Kornimate/medical-research-clean huggingface dataset:
empowering patients with chronic diseases through smartphone app, health coaching and shared decision making

Conditions: Diabetes Mellitus, Type 2; Hypertension

Summary: chronic diseases are the leading cause of deaths in singapore. the rising prevalence in chronic diseases with age and singapore's rapidly aging population calls for new models of care to effectively prevent the onset and delay the progression of these diseases. advancement in medical technology has offered new innovations that aid healthcare systems in coping with the rapid rising in healthcare needs. these include mobile applications, wearable technologies and machine learning-derived personalized behaviorial interventions. the overall goal of the project is to improve health outcomes in chronic disease patients through delivering targeted nudges via mobile application and wearable to sustain behavioral change. our overall objective is to design, develop, and evaluate an adaptive intervention platform on wearable devices and shared decision-making during consultations for patients with diabetes and hypertension. our aim for this study is to assess the clinical effectiveness of real-time personalized educational and behavioural interventions delivered through wearable (fitbit) and an integrative mobile application in improving patient glycaemic control measured using hba1c over 9 months. secondary outcomes will include change in systolic blood pressure, quality of life (qol), patient activation, medication adherence, physical activity level, diet, direct healthcare cost and indirect healthcare cost over 9 months. we will conduct a randomized controlled trial among patients with comorbid diabetes and hypertension. this proposal aims to develop sustainable and cost-effective behavioural change among patients with comorbid diabetes and hypertension through patient empowerment and targeted chronic disease care.


Eligibility criteria:
inclusion criteria: 1. aged 21 years old and above 2. have been diagnosed with diabetes at time of recruitment 3. most recent glycated haemoglobin (hba1c) ≥ 7.0% 4. systolic blood pressure≥ 140 mmhg or diastolic blood pressure ≥ 90 mmhg on two or more prior visits, physician-diagnosed hypertension, or on antihypertensive medication 5. physically able to exercise 6. literate in english 7. agreeable to be monitored by empower and/or fitbit apps 8. able to conform to monitoring schedule exclusion criteria: 1. on bolus insulin treatment 2. require assistance with basic activities of daily living (badl) 3. have planned major operation or surgical procedure within next 9 months 4. cognitively impaired (scored ≥ 6 on the abbreviated mental test)

Keywords: nudge wearable behavioural change
association of comorbidities with covid19

Conditions: COVID19

Summary: association of comorbidities with unfavorable covid19 outcomes as admission to intensive care, invasive ventilation or death.

covid19 is a new emerging, rapidly disseminating disease that consuming most of resources of efficient healthcare systems, and several hospitals, worldwide, are currently experiencing a shortage of icu beds for critically ill patients with covid-19 pneumonia. a risk stratification based on clinical, radiological and laboratory parameters seems necessary in order to better identify those patients who may need hospital and/or icu admission. one of the most alarming clinical parameters in general is the presence comorbidities. the underlying diseases including hypertension, diabetes mellitus, respiratory system disease and cardiovascular disease, may be risk factors for severe covid-19 patients with adverse outcomes compared with non-severe patients. obesity is also a risk factor for covid-19 severity with increased need to mechanical ventilation. chronic diseases share several features with infectious disorders, such as the proinflammatory state, and the attenuation of the innate immune response which may be linked etiologically to its pathogenesis. aim of the study:to assess the impact of comorbidities in patients with diagnosis of covid-19 on outcome, in order to find the predictors of prolonged hospital stay, need for icu admission or poor outcome

Eligibility criteria:
inclusion criteria: * diagnosis of covid-19 test positive; hospitalized subjects; both sexes. exclusion criteria: * no exclusion criteria
changes in choroidal thickness after non penetrating deep sclerectomy

Conditions: Choroidal Thickness; Open Angle Glaucoma; Non Penetrating Deep Sclerectomy

Summary: prospective and observational study to determine if choroidal thickness increases after non penetrating deep sclerectomy in patients with open angle glaucoma


Eligibility criteria:
inclusion criteria: * progressive primary open angle glaucoma exclusion criteria: * age under 18yrs * myopia or hyperopia higher than -6d or +6d * secondary glaucoma * ocular surgery other than cataract * other ocular pathology

Keywords: choroidal thickness open angle glaucoma non penetrating deep sclerectomy
efficacy, safety and tolerability study in subjects with parkinson's disease

Conditions: Parkinson's Disease

Summary: the b7441003 study will assess pf-06412562 for motor benefit in parkinson's disease subjects. safety, tolerability and pk of pf-06412562 in parkinson's disease subjects will also be evaluated.


Eligibility criteria:
inclusion criteria: * male or female subjects with a diagnosis of idiopathic parkinson's disease. * daily l-dopa dose between 300 and 1200 mg. * mbrs score \>1. exclusion criteria: * surgical intervention for parkinson's disease. * history of troublesome dyskinesias. * any significant axis i psychiatric disease.
assess the effect of daily treatment of vardenafil 20mg or sildenafil 100mg and placebo on sperm function

Conditions: Erectile Dysfunction

Summary: assess the effect of daily treatment of vardenafil 20mg or sildenafil 100mg and placebo on sperm function


Eligibility criteria:
inclusion criteria: * healthy male subjects or men with ed aged 25 - 64 * baseline sperm conc. of \> 20 mio / ml- normal world health organization a+b+c sperm mortality \> 50%- normal sperm morphology (who, 1992 manual criteria) \> 30% and - 1.0 ml ejaculate volume at each of the 3 analyses during the screening phase. exclusion criteria: * presence of any psychological or physiological abnormalities that in the opinion of the investigator would significantly impair sexual performance or ability to provide semen samples according to the protocol- spinal cord injury * history of surgical prostatectomy * other exclusion criteria apply according to us product information

Keywords: erectile dysfunction sildenafil vardenafil spermatogenesis sperm concentration sperm count morphology motility reproductive hormonal
a study of ym178 in patients with symptomatic overactive bladder (dragon)

Conditions: Overactive Bladder

Summary: the study will examine which dose of ym178 is best in terms of efficacy, safety and tolerability compared to placebo and compared to tolterodine, a marketed product.


Eligibility criteria:
inclusion criteria: * patients over 18 years suffering from overactive bladder (oab) for more than 3 months exclusion criteria: * pregnant and breastfeeding women * any medical condition or need for co-medication which interferes with the drug under investigation (ym178) or the comparator (tolterodine)

Keywords: over active bladder urinary incontinence ym178 symptomatic over active bladder
the research of standard diagnosis and treatment for hspn with mild proteinuria in children

Conditions: Henoch-Schoenlein Purpura Nephritis

Summary: this study is performed to evaluate the efficacy and safety of various measures in the treatment of hspn with mild proteinuria in children.

henoch-schonlein purpura nephritis (hspn) is one of the most common complications of henoch-schonlein purpura, and has become one of the main causes of chronic kidney disease in children. however, the diagnosis and treatment of hspn is still based on the clinical experience, lacking of evidence-based support. this study is performed to explore the biological markers for early prediction of the prognosis and evaluate the efficacy and safety of various measures in the treatment of hspn in children. the patients who are proved to get hspn by renal biopsy will be randomized to receive either prednisone p.o. or angiotensin-converting enzyme inhibitor(acei) p.o. we will follow up them for about 2.5 years and compare the efficacy and safety of both measures by monitoring several indexes.

Eligibility criteria:
inclusion criteria: * renal biopsy proved hspn (iskdc class ii) * proteinuria \< 25 mg/kg/d exclusion criteria: * the children with congenital diseases * proteinuria≥25 mg/kg/d

Keywords: mild proteinuria
refinement and testing of recruitment methodology for behavioral medication adherence interventions using behavioral science-based approaches

Conditions: Diabetes; Pharmacist-Patient Relations; Medication Adherence

Summary: the overarching goal of the proposed research is to prepare the clinical pharmacist intervention for sustainable implementation and dissemination. because the effectiveness of the intervention has already been demonstrated in a nih stage model iv trial, the investigators propose an effectiveness-implementation type 3 hybrid design, in which the primary focus is on testing different implementation methods, while secondarily observing clinical effects. the investigators' overarching hypothesis is to identify the most impactful elements of a behavioral theory-informed recruitment approach, which can be replicable across clinical settings. accordingly, the investigators propose to perform testing of a behaviorally-informed recruitment approaches in a community-based setting. like the previous tele-pharmacy intervention to improve treatment adherence (stic2it) trial (nct02512276), participants will be english or spanish speaking adults ≥18 years of age identified through the electronic health record (ehr) as having poor disease control and/or poor medication adherence for diabetes. the primary care physicians of eligible patients identified through the ehr will be contacted to opt-out any patients they wish not to be included. patients will then be randomized to each of the following conditions, such that there will be 8 total arms: (1) inclusion of a mailer primer (yes/no), (2) the most successful recruitment letter from the preliminary study using prospect theory (versus the control letter), and (3) intensity of the intervention outreach (4 calls vs. 2 calls). the investigators plan to enroll 584 participants who meet the inclusion criteria, with 73 patients per each of the 8 study arms. patients across all arms who agree to be scheduled will receive an appointment with one of the clinical pharmacists within the established bmc pharmacist program. the primary outcome will be completion of a clinical pharmacist appointment within 8 weeks after randomization. key secondary outcomes will include scheduled visit rates, no-show rates for scheduled appointments, medication adherence over the 3-month follow-up, and clinical outcomes, including hba1c levels measured using ehr data in the 3 months after randomization. the medication adherence and clinical outcomes will be used for the aim 2 evaluation.


Eligibility criteria:
inclusion criteria: * ≥18 years of age * english or spanish speaking * receiving care from a bmc primary care provider * non-adherent to prescribed oral glucose-lowering medications as per pharmacy dispense records (proportion of days covered \<80% to at least one eligible medication in last 6 months) * evidence of poor or worsening disease control exclusion criteria: * evidence of terminal conditions
acute effects of different macronutrient compositions and meal distributions of the food

Conditions: Metabolic Rate; Plasma Glucose; Serum Insulin; Serum Triglycerides; Sense of Satiety

Summary: about thirty participants, of varying degrees of obesity or being non-obese, without serious concomitant diseases consume either a high- or a low- carbohydrate beverage. the beverage is also consumed either as one single drink or as 5 small portions in the morning and are tested for effects on major cardiovascular risk markers and on metabolic rate for three hours on each occasion.

thirty participants come to the metabolic ward at about 8 o´clock in the fasting state and stay until lunch on four occasions each. the participants are randomized to the order of the test meals. the meals have a total caloric content of 750 kcal and have either 50% of energy from carbohydrates (low fat) or 20% of energy from carbohydrates (low carb.). the meals are consumed on one occasion in the morning or divided in 5 portions (150 kcal each) for every 30 minutes, i.e. total combinations of meal composition and of meal distribution is 4. effects of the food on p-glucose, s-insulin, blood-lipids, hormones and on metabolic rate is measured by blood tests or by indirect calorimetry (for metabolic rate). sense of satiety is measured by visual analogue scales.

Eligibility criteria:
inclusion criteria: * healthy participants \> 18 years with or without obesity exclusion criteria: * major illnesses, * thyroid diseases, * need to take prednisolone, * psychiatric disease, * inability to understand swedish
evaluation of music therapy for pre-op/intra-op during hernia surgery to decrease the need for narcotics

Conditions: Surgery; Pain, Postoperative

Summary: the purpose of this study is to investigate if audible distraction, in the form of music, before and/or during hernia repair surgery will decrease pain post-operatively.

after performing a thorough review of the literature, no studies were found that examined whether having a patient listen to a genre of music of their choosing before or during surgery impacts their postoperative pain. music is a way to relax patients and could potentially decrease pain, which is a goal of perioperative services. the current study seeks to fill the gap and examine the impact of music on pain for surgical patients undergoing a hernia repair. this study will use a randomized, double-blinded, controlled design with four arms: * arm 1: patient will listen to music before their surgery in pre-operative area only * arm 2: patient will listen to music before and during their surgery * arm 3: patient will listen to music during their surgery only * arm 4: patient will not listen to music during their visit

Eligibility criteria:
inclusion criteria: * aged 18 years or older * receiving surgery at bethesda surgery center exclusion criteria: * does not speak english * unable to consent to involvement in the research study * having more than 1 hernia repair performed * pregnant * deaf * wears hearing aids * currently on medication-assisted treatment for substance use disorder (ex: suboxone or methadone)
french national registry of bone marrow failures

Conditions: Bone Marrow Failure Syndrome

Summary: this is a unique clinical and biological database that collects standardized clinical information during the management of all patients with bone marrow failure syndromes (bmf) in france (multicenter registry), from diagnosis and throughout follow-up during the natural history of the disease, treated or not. in parallel, biological samples (blood and/or bone marrow and/or skin) are collected during clinical care and are biobanked in saint-louis hospital (hematology laboratory) in order to be used in translational research related to bone marrow failure diseases. this registry has two main objectives: * public health care evaluation and improvement: to assess the medical and social needs inherent to the management of these rare diseases; to precisely assess the level of diagnosis and management of bone marrow failure syndromes in france; to evaluate the impact and guidance of the french reference center guidelines for diagnosis and treatment; to evaluate the real-life efficacy and tolerance of any given specific treatments; to analyze treatment's cost-effectiveness according to each situation. * research: * epidemiology: to determine the incidence, prevalence, and distribution of different bone marrow failure syndromes at the national level; * biology: to better understand the pathophysiology of bmf; to identify and to study complications within each entity, such as mechanisms underlying clonal evolution, new forms of inherited bmf and acute myeloid leukemia (aml)/mds-predisposition syndromes, and to better and deeper characterize known entities; * treatment: to identify prognostic factors and predictors of response; to identify side effects and impact of treatment on others organs and natural functions; to assess patients' quality of life as early as possible since diagnosis and throughout follow-up.


Eligibility criteria:
inclusion criteria: * all age * all diagnostic of bmf * having given his non-opposition to registry after understand overall aims * having signed a written informed consent (2 parents for patients aged less than 18) for collection of biological samples * with health insurance coverage exclusion criteria: with myelodysplastic syndrome occurring in a patient over the age of 50 in absence of genetical predispositions, familial forms and history of medullary hypoplasia

Keywords: aplastic anemia fanconi anemia blackfan diamond anemia telomeropathies inherited aplastic anemia acquired aplastic anemia medullary hypoplasia
should maxillary buccal infiltration anesthesia be given in a closed mouth technique?

Conditions: Anesthesia, Local; Pain Control

Summary: to study the patients' and dentists' perception of receiving/ administering maxillary buccal infiltration anesthesia using an open or closed mouth techniques

background: local anesthesia is an essential part of dentistry. the most commonly used technique to anesthetise maxillary posterior teeth is buccal infiltration with a local anesthetic agent. the technique described in the literature focuses on the location of injection, the direction of the needle insertion in relation to the root apex, the direction of needle bevel in relation to the cortical bone plate, the size of needle and the type and amount of the local anesthetic agent used. however, there is no mention to whether the patient should open their mouth or maintain their teeth in intercuspation during the injection procedure. aims: this research aims to a) compare two techniques of injection (open and closed-mouth techniques) in terms of the discomfort experienced by patients during the injection procedure and b) evaluate the dentists' preference in performing either of the two techniques.

Eligibility criteria:
inclusion criteria: * adult patients (16 years old and older) * healthy (american society of anaesthesiologists (asa) category i or ii) * a maxillary posterior tooth (excluding third molars) referred for root canal treatment and diagnosed with irreversible pulpitis and normal apical tissues exclusion criteria: * psychological disorders * intraoral soft tissue abnormalities * necrotic pulp with/ without apical pathology * tenderness to palpation and/or percussion * the use of analgesics in the preceding 12 hours before the appointment.

Keywords: buccal infiltration anesthesia discomfort
monopolar dielectric diathermy by radiofrequency and therapeutic exercise in patients with chronic low back pain.

Conditions: Chronic Pain

Summary: a total of 60 people diagnosed with non-specific chronic low back pain of more than 3 months of evolution and who are not currently undergoing any type of treatment will be recruited, with ages between 30 and 65 years. a random distribution will be made into two treatment groups (diathermy combined with supervised therapeutic exercise versus supervised therapeutic exercise). participants will receive treatment once a week for a period of four weeks, in the physiotherapy laboratories of the university of almería, with a follow-up evaluation at three weeks and two months after the start of treatment. at their first visit, participants will be screened for study eligibility according to the study inclusion and exclusion criteria, and will be evaluated by a therapist blinded to the intervention. after this face-to-face evaluation, patients will be randomly assigned to one of the two groups and will receive treatment for low back pain according to their random assignment group by two therapists belonging to the research group and trained in the techniques used.

after randomization, participants will be assigned to the experimental group (8 sessions of monopolar dielectric diathermy by emission of radiofrequency combined with 8 sessions of supervised therapeutic exercise) or to the control group (8 sessions of supervised exercise). the number of participants will be identical between the groups. the randomization sequence will be performed by the principal investigator. the number of participants for each group will be 30. the results of the random assignment will be sealed in opaque envelopes before being delivered to the participants. the outcome assessor and study statistician will be blinded throughout the entire process. a baseline assessment of the primary and secondary outcome measures will be performed before randomization of the participants to the different groups, an immediate post-treatment assessment (1 day after the last intervention) and an assessment two months after the end of the procedure. intervention (follow-up).

Eligibility criteria:
inclusion criteria: * low back pain ≥ 3 months. * age between 30 and 67 years old. * score ≥ 4 points on the roland morris disability questionnaire. * not being receiving physical therapy. exclusion criteria: (1) patients with sensory and/or coagulation disorders; (2) a history of spinal surgery; (3) heart complications; (4) concurrent severe central or peripheral nervous system disease; (5) epilepsy; (6) needle phobia; (7) serious pathologies that can be the main cause of chronic lbp (for example, presence of lumbar stenosis, spondylolisthesis, tumours, etc.); (8) or patients contraindicated for radiofrequency (diathermy).

Keywords: non-specific chronic low back pain supervised therapeutic exercise monopolar dielectric diathermy randomised single-blind clinical trial
phase i biomarker study (bms-936558)

Conditions: Renal Cell Carcinoma

Summary: the purpose of this study is to evaluate the pharmacodynamic and biologic properties of bms-936558 in subjects with metastatic renal cell carcinoma.

intervention model: parallel dose comparison

Eligibility criteria:
for more information regarding bms clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * women and men ≥ 18 years of age. * histologic confirmation of renal cell carcinoma with a clear cell component. * measurable disease as defined by response evaluation criteria in solid tumors (recist). * tumor sites that can be accessed for repeat biopsies at acceptable clinical risk. * previously treated subjects must have failed at least 1 prior anti-angiogenic agent and can have a maximum of 3 prior systemic treatments for renal cell cancer. * subjects in the treatment naive arm cannot have received prior systemic therapy for their renal cell carcinoma. exclusion criteria: * active or progressing brain metastases. * active concomitant. * active or history of autoimmune disease. * active use of systemic corticosteroids. * prior therapy with cytotoxic t lymphocyte-associated antigen 4 (anti-ctla4), anti programmed death-1 (anti-pd1), anti programmed death ligand 1 (anti-pd-l1), anti programmed death ligand 2 (anti-pd-l2), anti-cd137, anti-cd40, anti-ox40 antibodies.