Kornimate/medical-research-clean huggingface dataset:
collection of whole blood samples for the evaluation of preeclampsia (pre-e) biomarkers from pregnant women

Conditions: Pre-Eclampsia; Hypertension; Proteinuria in Pregnancy; Thrombocytopenia; Renal Insufficiency; Impaired Liver Function; Pulmonary Edema; Headache; Visual Impairment

Summary: whole blood sample procurement study from pregnant women with signs and symptoms of preeclampsia.

this multicenter non-interventional observational sample acquisition study is designed to acquire whole-blood samples from pregnant women who present with signs and symptoms of pre-e and are in the care at an ob-gyn and/or maternal fetal medicine (mfm) site, defined as outpatient centers, clinic sites, and medical offices. study population includes subjects who are pregnant, of any race or ethnicity, 18 to 45 years of age, 28 0/7 to 36 6/7 weeks' gestational age with a singleton fetus and have provided written informed consent to provide whole blood specimens at one or more study visits.

Eligibility criteria:
inclusion criteria: * subject is 18 to 45 years of age * subject is willing to provide informed consent * subject enrolling at a study ob-gyn or mfm site is in the opinion of the physician able to provide 20 ml of whole blood and will comply with all study procedures * subject has a singleton fetus of 28 0/7 to 36 6/7 weeks' gestational age using 2014 acog dating criteria (pregnancies starting as twins but complicated with either vanishing twin syndrome or fetal demise of one twin before 14 weeks, are eligible for inclusion) * patient presenting with clinical suspicion of pre-e based on one or more of the following clinical signs and symptoms of pre-e: * new onset increased blood pressure in otherwise normotensive patient * worsening hypertension in a patient with pre-existing hypertension * new onset proteinuria or worsening of pre-existing proteinuria * any other clinical finding typically associated with suspicion of pre-e and requiring workup to rule-out pre-e exclusion criteria: * pregnancy is non-viable, as evidenced by absence of fetal cardiac activity * major fetal anomaly or chromosomal aneuploidy * current dialysis for kidney failure, including continuous ambulatory peritoneal dialysis

Keywords: hypertension proteinuria thrombocytopenia renal insufficiency impaired liver function pulmonary edema cerebral symptoms visual symptoms
clinical evaluation of the ethmoid sinus spacer

Conditions: Sinusitis, Chronic Rhinosinusitis

Summary: evaluation of treatment of the ethmoid sinuses with the ethmoid sinus spacer and access system


Eligibility criteria:
inclusion criteria: 1. age \> 21 years old 2. both male and female 3. ethmoid disease on ct scan 4. at least one non-ethmoid sinus requiring treatment 5. failed medical management and symptomatic exclusion criteria: 1. previous ethmoid surgery 2. not sufficient room for placement of spacer 3. patient requires septoplasty 4. has received steroid treatment with in 2 weeks 5. extensive sinonasal osteoneogenesis preventing device placement 6. sinonasal tumors or obstructive lesions 7. history of facial trauma that distorts sinus anatomy 8. asthmatic patients with aspirin sensitivity 9. pregnant or lactating females
perceived burden and quality of life of primary caregivers of cancer patients aged 70 and older after 5 years of management

Conditions: Quality of Life; Primary Patient Caregiver; Cancer

Summary: cancer is a disease that requires long-term management, especially now that medical advances have transformed most cancers from an acute to a chronic condition. most of the time, therefore, the help provided by family and friends is long-term. the negative impact of oncological care on the quality of life of family caregivers has already been studied. the ucogb carried out a study in 2014 on the primary caregivers of cancer patients aged 70 and over at inclusion and at 3 and 6 months of oncogeriatric care. this study showed that several factors were significantly related to the caregiver's quality of life: the caregiver's age, perception of burden and patient autonomy (18). however, the evolution of quality of life and burden at 5 years has, to our knowledge, never been evaluated.


Eligibility criteria:
inclusion criteria: * person who does not object to being included in the study * primary caregiver of a cancer patient aged 70 years and over who is managed in one of the centres participating in the study, with a request for an oncogeriatric consultation between 01/06/2014 and 18/03/2015. * age ≥ 18 years old * good command of the french language exclusion criteria: * refusal or linguistic or psychological inability to answer the questionnaires. * caregiver whose general condition does not allow him/her to answer a questionnaire * death of the caregiver.
decompressive craniectomy in malignant middle cerebral artery infarcts

Conditions: Malignant Middle Cerebral Artery Infarction

Summary: the purpose of this study is to determine if patients with malignant middle cerebral artery infarction have a better clinical outcome after early decompressive surgery compared to standard medical management.

the decompressive craniectomy in malignant middle cerebral artery infarction (decimal) trial is a prospective, multicenter, randomized, open (single blind for the evaluation of the primary outcome measure) controlled study of the efficacy of decompressive craniectomy plus the standard medical therapy as compared with the standard medical therapy alone in patients with a malignant middle cerebral artery infarction. the study protocol is approved by a regional ethic committee (ccpprb hospital saint louis, paris). the study is conducted in 13 stroke centers in france and is funded by the french ministry of health and the "assistance publique- hopitaux de paris". an independent data safety monitoring board (dsmb) monitors the safety, progress and ethics of the trial. the aim of the trial is to determine if patients with malignant middle cerebral artery infarction have a better clinical outcome after early decompressive surgery compared to standard medical therapy alone. secondary objectives are to determine clinical or mri based prognostic factors of better outcome after decompressive surgery.

Eligibility criteria:
inclusion criteria: * clinical and ct scan signs of complete infarction of the middle cerebral artery * onset of symptoms \< 30 hours to a possible surgical intervention (\< 24 hours for the inclusion and possibility to start treatment/surgery within 6 hours after randomisation) * dwi infarct volume \> 145 cm3 exclusion criteria: * the patients having a neurological pre existing handicap (score of rankin sup or equal in 2). * patients having an ischaemia lateral against significant. * patients having a haemorrhagic transformation(conversion) sup in 50 % of the territory of the infarct. * patients having a severe co-morbidity with a reduced life expectation. * patients having a severe cardio-respiratory co-morbidity. * patients having antecedent of duroplastie with transplant of dura mater or transplant of cornea. * patients having a thrombolyses in 24 last hours. * patients having a severe coagulopathies. * patients having one against indication in the general anesthetic. * patients for whom a medical follow-up is not possible. * the pregnant women. * the patients to whom the surgical operation cannot be realized within 6 hours following the randomisation.

Keywords: malignant middle cerebral artery infarction decompressive surgery hemicraniectomy brain edema
effectiveness of massage applied to hemodialysis patients

Conditions: Nurse's Role

Summary: this study was conducted to determine the effect of massage on comfort and fatigue levels of hemodialysis patients.

chronic renal failure (crf) is a health problem that causes significant mortality and morbidity worldwide. the prevalence of the disease is increasing worldwide, especially in developing countries. hemodialysis (hd) is the most common treatment method for crf in the world. approximately 90% of patients with crf receive hd treatment. despite advances in technology and medical care due to hd treatment, patients experience many physical and psychosocial symptoms. it is emphasized that comfort is significantly negatively affected in hd patients due to reasons such as the direct impact of hd treatment on the daily and social lives of patients. increasing the comfort level is important for the patient to continue their daily life activities. in addition, comfort is accepted as the basis of quality nursing care. increasing the comfort levels of hd patients provides lower comorbidity and mortality rates and improvement in institutional patient outcomes. fatigue, one of the physical symptoms seen in hd patients, affects 60-95% of patients. fatigue increases the patients' dependency levels, reduces their physical capabilities, negatively affects the patient and their family economically and reduces their quality of life. therefore, effective management of fatigue is of great importance for the patient. despite affecting the patients' lives to this extent, fatigue and discomfort have often been overlooked and neglected symptoms due to their subjective nature. various pharmacological and non-pharmacological treatment methods are used to control fatigue due to crf or hd and to bring the desired patient comfort. one of the non-pharmacological methods is massage. massage can be defined as scientific systematic manipulations applied to body tissues in order to affect the locomotor system and nervous system as well as the general circulation. there are studies in the literature where various applications are applied to hd patients to affect fatigue and comfort. however, it is striking that there is no study examining the effect of massage on the comfort and fatigue levels of patients receiving hd treatment. therefore, the research was planned to examine the effect of massage on the comfort level and fatigue level of hd patients.

Eligibility criteria:
inclusion criteria: * volunteering to participate in the study * being 18 years of age or older * receiving hemodialysis treatment in a dialysis unit for at least six months * not having a condition that prevents verbal communication * not having a psychiatric problem exclusion criteria: * patients who left the study at any stage * patients who had been receiving hemodialysis treatment for less than 6 months

Keywords: massage hemodialysis patients nursing comfort fatigue
safety and efficacy of nemolizumab in pn

Conditions: Prurigo Nodularis

Summary: the aim of this study is to assess the safety and efficacy of nemolizumab in subjects with prurigo nodularis.

this is a randomized, placebo-controlled, double-blinded, parallel group, multicenter study to evaluate the safety and efficacy of nemolizumab over a 12-week treatment period in patients suffering from prurigo nodularis compared to its placebo.

Eligibility criteria:
inclusion criteria: 1. male or female of at least 18 years at screening 2. clinical diagnosis of pn for at least 6 months with: * prurigo lesions on upper limbs with or without lesions on the trunk or lower limbs * at least 20 nodules on the entire body with a bilateral distribution 3. severe pruritus defined as follows on a numerical rating scale (nrs) * at the screening visit 1: mean of the worst daily intensity of the nrs score is ≥ 7 over the previous 3 days * at the baseline visit: mean of the worst daily intensity of the nrs score is ≥ 7 over the previous week; note: nrs score should be measured on at least 5 days during the week preceding the baseline visit. 4. female subjects must fulfill one of the criteria below: * female subjects of non-childbearing potential (postmenopausal \[absence of menstrual bleeding for 1 year prior to screening, without any other medical reason\], hysterectomy or bilateral oophorectomy); * female subjects of childbearing potential who agree to a true abstinence (when in line with the preferred and usual lifestyle of the subject), or to use an effective method of contraception throughout the clinical trial and for 120 days after the last study drug administration: exclusion criteria: 1. chronic pruritus resulting from another condition than pn such as scabies, insect bite, lichen simplex chronicus, psoriasis, acne, folliculitis, habitual picking, lymphomatoid papulosis, chronic actinic dermatitis, dermatitis herpetiformis, sporotrichosis, bullous disease 2. unilateral lesions of prurigo (e.g only one arm affected) 3. cutaneous bacterial or viral infection within 1 week before the baseline visit. 4. infection requiring treatment with oral or parenteral antibiotics, antivirals, antiparasitics or antifungals within 1 week before the screening visit, or during the screening period, unless completely resolved at the screening/ baseline visits respectively, 5. any uncontrolled or serious disease, or any medical or surgical condition, that may either interfere with the interpretation of the clinical trial results and/or put the subject at chronic pruritus resulting from another condition than pn such as scabies, insect bite, lichen simplex chronicus, psoriasis, acne, folliculitis, habitual picking, lymphomatoid papulosis, chronic actinic dermatitis, dermatitis herpetiformis, sporotrichosis, bullous disease
efficacy of oxygen therapy delivered by systems using oxygen-saving valves in copd patients

Conditions: LUNG DISEASES, OBSTRUCTIVE

Summary: the purpose of this study is to compare the efficacy of oxygen therapy delivered by systems using oxygen-saving valves or not (continuous oxygen). we aim to determine if systems using oxygen-saving valves are equally effective as continuous oxygen delivery systems in reducing exercise-induced hypoxemia in patients with copd.


Eligibility criteria:
inclusion criteria: * copd on necessity of long term oxygen therapy * able to give their written consent exclusion criteria: * unstable patients with copd * patients with restrictive respiratory disease * patients with cardiac or neurologic disease contre-indicating the different evaluations

Keywords: copd - long term oxygenotherapy copd patients with respiratory failure
a comparative study between laryngeal mask airway and magensium sulphate in attenuating systemic stress response during emergence of patients undergoing supratentorial tumours.

Conditions: LMA Versus Mgso4 in Attenuating Stress Response During Emergence of Supratentorial Tumours Patients

Summary: to evaluate the efficacy of replacement of ett with lma and administration of magnesium sulphate at the end of the surgery in attenuating systemic stress response during emergence of patients undergoing supratentorial tumours

rapid recovery from neuroanesthesia and early neurological examination are desirable in most cases.(1)although, systemic and cerebral hemodynamic changes caused by extubation and emergence from anesthesia may endanger neurosurgical patients and increase the risk of postoperative intracranial hemorrhage and cerebral edema and may even result in the requirement of reoperation.(2) during this phase, heart rate and arterial blood pressure increase leading to increases in cerebral blood flow and intracranial pressure.(3) some studies have reported such hemodynamic effects in up to 50% of patients after supratentorial craniotomy.(4,5) replacing the endotracheal tube (ett) with laryngeal mask airway (lma) prior to emergence from anesthesia is safe and effectively reduces the cardiovascular response.(6) the potential protective benefit of this approach has not yet been demonstrated for awakening neurosurgery patients, however. magnesium is the forth most abundant cation in the body and the second most abundant intracellular cation. it activates many of the enzyme systems.(7) magnesium sulphate inhibits catecholamines release from adrenergic nerve terminals and from adrenal medulla, through blocking n-type of ca-channel at peripheral sympathetic nerve ending so it is used to decrease the adverse cardiovascular effects during larygeoscopy and endotracheal intubation.(8) but its role in attenuating stress response during extubation is not well studied and need more research.

Eligibility criteria:
inclusion criteria: 1. asa physical status i, ii. 2. ages between 18 and 60 years. 3. body mass index (bmi) \< 30. 4. elective surgery exclusion criteria: 1. patients have cardiovascular, pulmonary, renal, hepatic and endocrine diseases. 2. patients have any degree of disturbed conscious level. 3. ages \ 60 years. 4. bmi \>30. 5. patients have history of allergy to magnesium sulphate. 6. patients have uncontrolled hypertension during preoperative assessment. 7. patients have risk of aspiration (eg. hiatus hernia) 8. patients have difficult airway management during intubation with direct laryngoscope or time of intubation \>30 seconds. 9. failed ventilation with lma. 10. emergency surgery.
evaluating the efficacy of microneedling in the treatment of androgenetic alopecia

Conditions: Androgenetic Alopecia

Summary: androgenetic alopecia is the most common non scarring alopecia worldwide. treatment of which has been limited with few options for medical and surgical treatment, the cost of the latter being prohibitive for many. recently there have been several new modalities proposed as treatment, namely microneedling and platelet rich plasma. microneedling has been shown to overexpress hair growth factors which may enhance or stimulate miniaturized hairs to grow. it has also been shown to increase the absorption of topical products significantly. the exact mechanism of action of microneedling is still being delineated. in this study, we aim to do a half lesional study with global photographs and hair counts done at the start of , week four and week twelve. patients would be needled once weekly after application of topical anaesthetic (5% emla). if by week six there is significant regrowth (\>30%), then total lesional needling will be done. patients will only be using topical 5% minoxidil throughout the study as this will prolong the effects of the regrowth.


Eligibility criteria:
inclusion criteria: 1. men between the ages 18-65. 2. disease stage: norwood hamilton iiia-iv. 3. length of time with disease \< 10 years. exclusion criteria: 1. must not have other concurrent hair disease. 2. have not used any oral anti androgen (finasteride or dutasteride) in the past six months. if so, a washout period is needed. one month for finasteride and three months for dutasteride. 3. patients under the age of 18. 4. patients who are unable to offer consent.
rhomboid intercostal and sub-serratus block

Conditions: Rhomboid Intercostal Block

Summary: the rhomboid intercostal block (rib) can provide good analgesia effects after thoracic surgery . the ultrasound-guided rib is novel analgesic techniques recently described by elsharkawy et al. . additionally, the riss block anesthetizes the lateral cutaneous branches of the thoracic intercostal nerves and can be used in multiple clinical settings for chest wall and upper abdominal analgesia. however, the analgesic effects of the riss block after breast surgery have not been analyzed through a randomized-controlled trial.


Eligibility criteria:
inclusion criteria adult patients between 18-50 years. asa physical status i and ii male gender exclusion criteria patient refusal contraindications to regional anesthesia known allergy to local anesthetics bleeding disorders use of any anti-coagulants inability to provide informed consent asa iii-iv -
effectiveness of a mobile health program in pregnant women

Conditions: Pregnancy; Gestational Age and Weight Conditions; Eating Behaviors; Literacy; E-learning

Summary: 1. to evaluate the usability and user experience of the i-pregmom mobile application and digital dietary image recording among pregnant women. 2. to examine the effectiveness of digital mobile health interventions on blood glucose levels and gestational weight gain among pregnant women from 10-14 weeks to 24-28 weeks of gestation.

1. sociodemographic variables: age, education level, marital status, occupation, and socioeconomic status. 2. obstetric variables: gravidity, history of miscarriage, pregnancy complications, and mode of delivery. 3. pre-pregnancy bmi. 4. dietary habits, perceived healthy eating behaviors, and dietary patterns. 5. psychological distress and depressive symptoms. 6. gestational blood glucose levels and gwg

Eligibility criteria:
inclusion criteria: * primiparous women aged ≥18 years. singleton pregnancy. pregnant women between 10 and 14 weeks of gestation, with gestational age calculated based on the first day of the last menstrual period. able to listen, speak, read, and write in chinese. willing to provide prenatal weight and blood glucose data. possess a mobile communication device (such as a smartphone or social media account) and be able to receive emails. exclusion criteria: * engaged in weight loss activities prior to pregnancy. diagnosed with chronic illnesses that may affect weight changes (e.g., psychiatric disorders, thyroid diseases).

Keywords: pregnancy health literacy e-learning gestational weight gains nutriention
clinical and anatomical evaluation of healing of lesions of the subscapular tendon

Conditions: Shoulder Injuries

Summary: this study is based on the hypothesis that fatty infiltration postoperative is not or only slightly modified after an atomic repair of lesions of the subscapularis tendon according to a new arthroscopic classification.

after repair of isolated lesions of the subscapularis, it is observed, in nearly half of the cases, a increased fatty infiltration of the subscapularis muscle indicating a probable persistence of the tendon rupture while the healing failure rate is recognized as moderate (about 15%). this study is based on the hypothesis that fatty infiltration postoperative is not or only slightly modified after an atomic repair of lesions of the subscapularis tendon according to a new arthroscopic classification.

Eligibility criteria:
inclusion criteria: * patient, male or female, aged ≥ 18 years * patient who has undergone surgical repair for a rupture or rotator cuff injury involving the subscapularis tendon between april and september 2016 and between may 2018 and january 2019 * patient with a lesion of the subscapularis tendon characterized with arthroscopic classification * patient who has previously participated in the classification study of subscapularis tendon injuries based on findings arthroscopy conducted only at the jean mermoz hospital exclusion criteria: * patient with a contraindication to mri