Kornimate/medical-research-clean huggingface dataset:
abbott i-stat high sensitivity troponin i study

Conditions: Myocardial Infarction

Summary: the goal of this observational multi-center study is to evaluate the clinical performance of the i-stat hs-tni test (i-stat high sensitivity troponin i) using the investigational i-stat hs-tni cartridge for the proposed intended use as an aid in the diagnosis and treatment of myocardial infarction (mi). the cartridge measures cardiac troponin i (ctni) in whole blood or plasma samples using the i-stat 1 analyzer or i-stat alinity instrument. subjects presenting to the emergency department (ed) with chest discomfort or equivalent ischemic symptoms suggestive of acute coronary syndrome (acs) who are enrolled in this study will be asked to provide blood samples for testing.

the i-stat high sensitivity troponin i (i-stat hs-tni) test is an in vitro diagnostic test for the quantitative measurement of cardiac troponin i (ctni) in whole blood or plasma samples using the i-stat 1 analyzer or i-stat alinity instrument in point of care or clinical laboratory settings. the hs-tni test is intended to be used as an aid in the diagnosis of myocardial infarction (mi). the objective of this study is to evaluate the clinical performance of the i-stat hs-tni test using the investigational i-stat hs-tni cartridge with the i-stat 1 analyzer and i-stat alinity instrument for subjects presenting to the emergency department (ed) with chest discomfort or equivalent ischemic symptoms suggestive of acute coronary syndrome (acs). the clinical evaluation will use prospectively collected whole blood specimens from subjects presenting to the ed with chest discomfort or equivalent ischemic symptoms suggestive of acs.

Eligibility criteria:
inclusion criteria: * subject is 18 years of age or older * presenting to the emergency department (ed) with signs and symptoms suggestive of acute coronary syndrome (acs): acute chest, epigastric, neck, jaw or arm pain or discomfort or pressure without apparent non-cardiac source; shortness of breath, nausea, vomiting, fatigue/malaise; other equivalent discomfort suggestive of a myocardial infarction (mi) in accordance with the american college of cardiology foundation/american heart association task force on practice guidelines. * electrocardiogram (ecg) ordered as part of the standard of care exclusion criteria: * previously enrolled in the study * enrolled in any interventional clinical trial (within the last 30 days)
lockdown impact on spontaneous premature birth in a level iii nicu

Conditions: Premature Birth; Preterm Labor

Summary: preterm labor (pl) is the leading cause of hospitalization during pregnancy and premature birth the leading cause of fetal morbidity and mortality in france. pl is defined by regular and painful uterine contractions associated with a change in the cervix, between 22 and 36 weeks of gestation. it has been shown that the risk of spontaneous prematurity increases particularly in case of working over 40 hours per week, hard physically conditions, or prolonged daily transport time. rest is one of the most efficient measure to prevent pl and should be proposed to all pregnant women, and combined with other therapies such as tocolysis or cerclage when needed. the very particular period of lockdown during the covid-19 pandemic had pregnant women to drastically reduce their activity. they suspended their work and stayed home for various reasons such as pregnancy in progress, children at home, and also collective reasons such as teleworking or workplace closure. during the lockdown period from march 17th to may 11th 2020, fewer preterm labor and less spontaneous prematurity have been suspected by the neonatology and obstetrics teams throughout the lorraine region. our study aims to objectively confirm this observation. in this investigation we aim to find a relationship between lockdown, pl and spontaneous prematurity which would need to re-evaluate public health recommendations for pregnant women outside the lockdown.


Eligibility criteria:
inclusion criteria: * any prematurely born infant before 37 sa and care for by the level iii nicu, over the predefined periods. exclusion criteria: * non premature newborn
effect of dentifrice usage regime on delivery and efficacy of fluoride

Conditions: Dental Caries

Summary: this study will evaluate and compare the effect of the amount of toothpaste used and brushing time on enamel strengthening (percent of surface microhardness recovery, % smhr) and enamel fluoride uptake (efu).


Eligibility criteria:
inclusion criteria: general and dental health * good general and dental health with (in the opinion of the investigator) no clinically significant and relevant abnormalities of medical history or oral examination * have no current active caries or periodontal disease that may compromise the study or the health of the subjects * residency: currently living in the indianapolis, indiana area dentures: * currently wearing a removable mandibular partial denture with sufficient room in the posterior buccal flange area to accommodate two enamel specimens (required dimensions 12 mm x 7 mm) * willing to have their denture modified to accommodate enamel test specimens and willing and capable of wearing their removable mandibular partial dentures 24 hours per day during the experimental periods * all restorations in a good state of repair * salivary flow: have a salivary flow rate in the range of normal values (unstimulated whole saliva flow rate ≥ 0.2 ml/minute; gum base stimulated whole saliva flow rate ≥ 0.8 ml/minute) exclusion criteria: * antibiotics: use of antibiotics two weeks prior to a treatment visit or anticipated use during the study treatment periods * study scale use: subjects unable to measure product weights accurately using the assigned study scale as determined by the study staff (as demonstrated on or before visit 4) * a member of the site study staff who is directly working on the project or living in that staff's household * any employee of any toothpaste manufacturer or their spouse or family member
neuropsychological rehabilitation of spontaneous confabulation

Conditions: Memory Disorders

Summary: confabulators consistently generate false memories without intention to deceive and with great feeling of rightness. however, there is currently no known effective treatment for them. in order to fill this gap, the aim of this trial was to design a neuropsychological treatment based on the current theoretical models and test it experimentally in two groups of confabulators: experimental vs. control. the treatment consisted of some brief material that patients had to learn and recall at both immediate and delayed moments. after both recollections, patients were given feedback about their performance (errors and correct responses). pre-treatment and post-treatment baselines were administered. confabulators in the control group performed the baselines without treatment, and were then offered the treatment after the second baseline.


Eligibility criteria:
inclusion criteria: * the presence of spontaneous confabulations after acute brain injury, for at least three months and without clinical improvement (interfering with the patient's daily life with frequent arguments and exhaustive supervision). * the presence of momentary confabulations in the spanish adaptation of dalla barba provoked confabulation interview. * prior to injury, all patients should be completely independent for daily living. exclusion criteria: * the presence of impairment in alertness. * dementia. * acute confusional state. * a history of alcohol or drug abuse. * psychiatric antecedents.

Keywords: confabulations neuropsychological rehabilitation memory
the effect of endotracheal tube with stylet in morbidly obese patients

Conditions: Intubation; Difficult or Failed; Obesity, Morbid

Summary: the investigators aimed to compare the effects of using enotracheal tube with stylet versus endotracheal tube alone in morbidly obese patients undergoing sleeve gastrectomy.

different intubation techniques have been used in morbidly obese patients undergoing general anesthesia. no study comparing the use of endotracheal tube with or without stylet was found in literature. thus, the investigators aimed to compare the effects of using enotracheal tube with stylet versus endotracheal tube alone in morbidly obese patients undergoing sleeve gastrectomy.

Eligibility criteria:
inclusion criteria: body mass index over 30 asa physical status i-iii undergoing laparoscopic sleeve gastrectomy - exclusion criteria: body mass index under 30 asa physical status iv unable to cooperate refused to give writtten informed consent-

Keywords: different intubation techniques endotracheal tube obesity stylet
abdominal muscles recovery response to kinesiotaping in women with postnatal diastasis

Conditions: Diastasis Recti

Summary: this study aims to investigate abdominal muscle recovery in response to kt by using objective method for assessment as digital caliper, and waist circumference. kt technique will include rectus abdominis, internal and external oblique muscles among females after normal vaginal delivery.


Eligibility criteria:
inclusion criteria: 1. age will range from 25-35 years. 2. all women give birth by normal vaginal delivery. 3. diastasis recti more than 2.5 cm at any point along linea alba. 4. body mass index (bmi) less than 30 kg/m2. 5. after the end of puerperium period i.e. after eight weeks postnatal. exclusion criteria: 1. women with skin over sensitivity to tape. 2. women with abdominal skin diseases. 3. abdominal hernia. 4. previous cesarean section. 5. multiple pregnancies more than 3 times. 6. other abdominal or back operation. 7. pregnancy related complications such as polyhydramnios, fetal macrostomia, diabetes, and hypertension. 8. spinal disorders. 9. lower limbs deformities.
evaluation of loteprednol etabonate versus vehicle for the treatment of inflammation and pain following cataract surgery

Conditions: Inflammation; Pain

Summary: this study is being conducted to compare the safety and efficacy of loteprednol etabonate to vehicle for the treatment of postoperative inflammation and pain following cataract surgery.


Eligibility criteria:
inclusion criteria: * subjects who are at least 18 years of age. * subjects who are candidates for routine, uncomplicated cataract surgery. exclusion criteria: * subjects who have known hypersensitivity or contraindication to the study drug or components. * subjects with a severe/serious ocular condition, or any other unstable medical condition, that in the investigator's opinion may preclude study treatment or follow-up. * subjects with elevated intraocular pressure (\>/=21mm hg), uncontrolled glaucoma, or being treated for glaucoma in the study eye. * subjects who are monocular or have pinholed snellen visual acuity (va) 20/200 or worse in the non-study eye.
the relationship between belief, expectation, and adherence to therapy during covid-19 pandemic

Conditions: Ischemic Heart Diseases

Summary: the goal of this \[type of study: observational study or clinical trial \] is to learn about, test, compare etc.\] in \[ describe participant population/health conditions \]. the main question \[ it aims to answer are: * \[question * \[question participants will \[describe the main tasks participants will be asked to do, treatments they'll be given and use bullets if it is more than 2 items \]. if there is a comparison group: researchers will compare insert groups \] to see if insert effects


Eligibility criteria:
inclusion criteria: * all patients diagnosed with ischaemic heart disease established by angiography; * reaching the age of majority; * score \>= 26 on the montreal cognitive assessment (moca) test (nasreddine et al., 2005). exclusion criteria: * presence of comorbidity with other pathologies in an active or advanced phase; -patients with a prognosis to be defined; * pregnancy; * participants with neurological pathologies that significantly impair their cognitive functions (e.g. advanced parkinson's disease; alzheimer's dementia...cardiac arrest with hypoxic damage); * participants with cognitive impairments that compromise comprehension and sharing of the contents of the questions, detected through the administration of the montreal cognitive assessment (moca) test (nasreddine et al., 2005).

Keywords: ischemic heart disease adherence belief acceptance covid-19
natural history of cherubism observational study

Conditions: Cherubism

Summary: to observe the natural history of cherubism.

the investigators will take a history and examine patients with cherubism to determine the natural history of the disease. the investigators also may take skin or blood samples (irb approved 7256) from patients to learn more about this disorder.

Eligibility criteria:
inclusion criteria: patients with cherubism exclusion criteria: patients without cherubism

Keywords: cherubism bone tumors
monovision for the treatment of diplopia

Conditions: Strabismic Deviation

Summary: purpose: the purpose of this study is to quantitatively assess the efficacy of monovision correction in the treatment of acquired small angle binocular diplopia in adult patients. method: twenty patients with symptomatic diplopia were enrolled in a prospective treatment trial. all had stable deviations of 10 prism diopters or less for over three months. each received monovision spectacles and/ or contact lenses with distance correction in the dominant eye. half received a +3.00 diopter (d) add and the others received +2.50 d. the validated and standardized diplopia questionnaire and amblyopia and strabismus questionnaire (asqe) were used to quantify the efficacy of monovision correction for diplopia by measuring the functional impact on vision-specific quality of life.


Eligibility criteria:
inclusion criteria: * strabismic deviation less than 12 prism diopters exclusion criteria: * inability to sign informed consent

Keywords: strabismic deviation less than 12 prism diopeters
the evaluation of effect of sanyinjiao (sp6) acupressure on early diabetic nephropathy

Conditions: Diabetic Nephropathy

Summary: for diabetic patient with persisted albuminuria under the intensive control on blood pressure and blood glucose, the non-invasive method of acupressure at sanyinjiao (sp6) is easy to use and significantly effect on albuminuria reduction in patients of diabetic nephropathy.


Eligibility criteria:
inclusion criteria: 1. age between 20 and 80 years old; 2. hba1c was lower than 9% according to the ngsp(national glycohaemoglobin standardisation programme); 3. estimated glomerular filtration rate (egfr) was more than 60 ml/min/1.73 m2. exclusion criteria: 1. hyperglycemic crisis, including hhs(hyperglycemic hyperosmolar syndrome) and dka(diabetic ketoacidosis ); 2. persist diabetes poorly control, hemoglobin a1c \[hba1c\] \>9%; 3. endocrine disorders: such as abnormal function of thyroid, pituitary, and sex glands; 4. heart diseases:such as arrhythmia, myocardial infarction, heart failure, or installed pacemaker; 5. immune and allergic diseases: such as systemic lupus erythematosus and asthma; 6. liver or kidney dysfunction: got or gpt(glutamate-pyruvate transaminase ) \> 80 iu/l, egfr\<60 (ml/min); 7. pregnant or lactating women; 8. less than 6months postpartum; 9. acute illness, fever, lower urinary tract infection, nsaid(nonsteroidal antiinflammatory drug) administration; 10. physical dysfunction because of stroke.
triaging and referring in adjacent general and emergency departments

Conditions: Triage

Summary: introduction: patients who might also go to the general practitioner (gp) frequently consult emergency departments (ed). this leads to additional costs for both government and patient and a high workload for emergency physicians in flanders. the belgian government wants to address this problem by improved collaboration between eds and general practice cooperatives (gpcs). intervention: patients presenting at the ed during out-of-hours (ooh) will be triaged and allocated to the most appropriate service. for this purpose the manchester triage system (mts) which is commonly used in flemish hospitals, will be extended (emts). by doing so a trained nurse will be able to diverge suitable patients towards the gpc. methodology: the investigators will conduct a cluster randomised controlled trial in which eligible ed patients will be diverged to the gpc using the emts. the investigators will collect data using the icaredata database. the investigators will study the use of the emts, the effectiveness and effects of triage, work load changes, epidemiology at both departments, patient safety, health insurance (his) and patient expenditures. furthermore, facilitators and barriers will be studied and an incident analysis of problem cases will be performed. outcome: the primary outcome is the proportion of patients who enter the ed and are handled by the gp after triage. secondary outcome measurements are related to safety: referral rate to the ed by the gp, proportion of patients not following the triage advice and file review for selected patients.


Eligibility criteria:
inclusion criteria: * availability of a belgian citizen national insurance number exclusion criteria: * patients arriving at the ed by an ambulance with a doctor or nurse * patients all ready admitted to an other hospital department

Keywords: triage primary health care emergency service, hospital
artificial intelligent decision support for skin cancer diagnostics in primary care

Conditions: Skin Cancer

Summary: background: artificial intelligence has in numerous studies shown high accuracy in detecting skin cancer when trained on various databases of dermatoscopic images. however, there are very few prospective studies conducted in real clinical settings directed at patients seeking healthcare for assessment of skin lesions, and nosuch studies at all in primary care, where the majority of patients are managed. project aim: to study the accuracy, reliability, and clinical utility of an ai-based decision support system (dermalyser), developed for primary care, in distinguishing skin cancer from benign lesions. method: cluster-randomized controlled trial at approx. 30 primary care centers in sweden, germany, scotland, the netherlands and australia. at study start, the participating primary care centres in each country are equally randomised to either be enabled to use the dermalyser (intervention phase) or to assess patients according to the standard clinical procedure (control phase). when half of the intended sample size (i.e. 1500 of 3000 participants) have been included, the primary care centres switch phase from intervention to control, or vice versa. during the intervention phase, the physicians may use (if found indicated) dermalyser as a part of their clinical evaluation, whereas during the control phase the physicians follow their ordinary diagnostic routine without support from dermalyser. this will direct the participants to either an intervention or a control cohort. both groups will be followed for up to 5 years, with regard to the tumour diagnoses, proportions of skin cancer/benign lesions, and morbidity and mortality in skin cancer. possible between-group differences will be investigated statistically. potential benefits: if the dermalyser prooves to be safe and diagnotically reliability, it could enhance the chance of detecting skin cancer in early stage in primary care, and to reduce the proportion of benign skin lesion unnecessarily excised or referred to dermatologist.


Eligibility criteria:
inclusion criteria: * patients attending a primary care facility in order to have one or more skin lesions checked for skin cancer, or patients presenting with one or more skin lesions raising suspicion of skin cancer when noticed by the primary care physician. * willingness and ability to provide informed consent. exclusion criteria: * individuals with skin type v and vi according to the fitzpatrick's scale (darker brown or black coloured skin)

Keywords: artificial intelligence (ai) primary care diagnostics
topical imiquimod compared with surgery in treating patients with basal cell skin cancer

Conditions: Non-melanomatous Skin Cancer

Summary: rationale: biological therapies such as imiquimod use different ways to stimulate the immune system and stop cancer cells from growing. it is not yet known if topical imiquimod is more effective than surgery in treating basal cell skin cancer. purpose: this randomized phase iii trial is studying how well topical imiquimod works compared to surgery in treating patients with basal cell skin cancer.

objectives: * compare the rate of local recurrence at 3 years in patients with nodular or superficial basal cell skin cancer treated with imiquimod 5% cream vs excisional surgery. * compare recurrence at 6 months and 1, 2, and 5 years in patients treated with these regimens. * compare the time to first recurrence in patients treated with these regimens. * compare the aesthetic appearance of lesion sites in patients treated with these regimens. * compare pain in patients treated with these regimens. outline: this is a randomized, multicenter study. patients are stratified according to participating center and lesion type (nodular vs superficial). patients are randomized to 1 of 2 treatment arms. * arm i: patients receive topical imiquimod to a single lesion once daily for 6 weeks for a superficial lesion or 12 weeks for a nodular lesion. patients with early treatment failure or recurrence are offered surgical excision. * arm ii: patients undergo surgical excision. patients are followed at 6, 12, and 18 weeks, every 6 months for 1 year, annually for 2 years, and then at 5 years. peer reviewed and funded or endorsed by cancer research uk projected accrual: a total of 500 patients will be accrued for this study within 18 months.

Eligibility criteria:
disease characteristics: * histologically confirmed primary basal cell skin carcinoma * nodular or superficial lesion(s)\* * located in low-risk areas note: \*any number of lesions are allowed but only 1 lesion per patient is selected for the study * no genetic or nevoid conditions (e.g., gorlin's syndrome) * no morphoeic (microinfiltrative) histology patient characteristics: age * any age performance status * not specified life expectancy * not specified hematopoietic * no bleeding disorder hepatic * not specified renal * not specified other * not pregnant or nursing * negative pregnancy test * fertile patients must use effective contraception during and for up to 1 month after study participation * no allergy to any of the study interventions * no life-threatening disease * must be available for study follow-up for up to 3 years * must have access to a telephone prior concurrent therapy: biologic therapy * not specified chemotherapy * not specified endocrine therapy * not specified radiotherapy * not specified surgery * not specified other * no concurrent participation in any other experimental trial

Keywords: basal cell carcinoma of the skin