Kornimate/medical-research-clean huggingface dataset:
single-step functional sinus endoscopy and transoral surgery

Conditions: Maxillary Sinusitis

Summary: dento- alveolar or dental structural diseases that affect the floor of the maxillary sinus can cause maxillary sinusitis which is known as odontogenic maxillary sinusitis (oms). many treatment protocols have been documented to treat oms. however, there is no unanimity among clinicians on how and who should treat oms, whether is it otolaryngologist, oral/maxillofacial surgeons, or dentist. therefore, this study will be will be enrolled to evaluate the efficacy of the single-step functional sinus endoscopy and trans-oral surgery in the management of maxillary sinusitis raised from odontogenic origin via department- integrated therapy.

the oms is a well-known but understudied kind of sinusitis that necessitates a treatment regimen different from non-odontogenic sinusitis. it requires specialized attention because it differs in its pathophysiology, microbiology, diagnosis, and therapy than other forms of non-odontogenic sinusitis. there are several surgical techniques have been published to treat odontogenic maxillary sinusitis, such as transoral, transnasal endoscopic, or combined techniques. multiple specialists are daily facing patients with maxillary sinusitis either odontogenic or non-odontogenic, including otolaryngologist, maxillofacial/oral, and dental surgeons. the direct transoral method, which involves making a bone window in the anterolateral maxillary wall, is more familiar to maxillofacial/oral surgeons, whereas the transnasal endoscopic approach is gaining favor, particularly among otolaryngologists. there is no unanimity among clinicians on how and who should treat oms, whether it is otolaryngologist, maxillofacial, or oral surgeon. this is one of the reasons why the results are frequently challenged as reported by others. therefore, this study will be will be enrolled to evaluate the efficacy of the single-step functional sinus endoscopy and trans-oral surgery in the management of maxillary sinusitis raised from odontogenic origin via department- integrated therapy.

Eligibility criteria:
inclusion criteria: 1. a diagnosis of oms that is not responding to dental treatment and/or medical treatment 2. agreement on the odontogenic cause between an ent specialist and a dentist/maxillofacial surgeon (there is bone loss surrounding the tooth's root and a connection between the dental lesion and sinus on ct scans) 3. availability of clinical, radiographic, and ess data. exclusion criteria: 1. maxillary sinus malignancy 2. sinuses with a previous surgery 3. non-odontogenic sinusitis

Keywords: maxillary sinusitis odontogenic maxillary sinusitis
efficacy and safety study of ifx-1 in patients with moderate to severe hidradenitis suppurativa (hs)

Conditions: Hidradenitis Suppurativa (HS)

Summary: the purpose of this study is to determine whether ifx-1 is safe and effective in the treatment of moderate to severe hidradenitis suppurativa.

hidradenitis suppurativa (hs) is a chronic devastating skin disorder affecting areas rich in apocrine glands. hs is diagnosed by its clinical features and its chronicity. it is recognized by the presence of recurrent, painful, deep-seated, rounded nodules usually ending in abscesses and sinus tracts with suppuration and hypertrophic scarring. as complement c5a is involved in the underlying acute inflammatory responses, this study is set up based on the hypothesis that ifx-1 might be able to block c5a induced pro-inflammatory effects such as neutrophil activation and cytokine generation, potentially contributing to the local skin inflammation and tissue damage.

Eligibility criteria:
inclusion criteria: * male or female, ≥ 18 years of age * written informed consent obtained from subject * diagnosis of hs for at least 1 year * moderate or severe hs, as indicated by hs lesions in at least 2 distinct areas, 1 of which must be at least hurley stage ii or stage iii * inadequate response to at least 3 months of oral antibiotics, or intolerance to antibiotics * total abscess and inflammatory nodule (an) count of ≥ 3 exclusion criteria: * prior treatment with adalimumab or another biologic product during the 24 weeks before screening * subjects on permitted oral antibiotic treatment for hs (doxycycline or minocycline only) who have not been on a stable dose during the 28 days before screening * subject received systemic non-biologic therapy for hs with potential therapeutic impact for hs during the 28 days before screening (other than permitted oral antibiotics) * prior treatment with any of the following medications during the 28 days before screening: * any other systemic therapy for hs * any iv anti-infective therapy * phototherapy (ultraviolet b or psoralen and ultraviolet a) * history of heart disease or malignancy

Keywords: hidradenitis suppurativa monoclonal antibody complement factor c5a ifx-1 hidradenitis suppurativa clinical response inflammation skin diseases
gamaline®+hipericin® for pms treatment and vasomotor symptoms

Conditions: Premenstrual Syndrome; Uterus; Hemorrhage, Preclimacteric or Premenopausal

Summary: 2 phytomedicines already in the market: gamaline® for premenstrual syndrome and hipericin® as antidepressant will be prescribed together for treating women with premenstrual syndrome (pms) symptoms and vasomotor problems for checking the advantage compared to the gamaline® prescription alone.

test with 2 female groups: 25-44 years old (reproductive age) and 45-55 years old (climacteric premenopausal age) complaining about all symptoms related with premenstrual syndrome.

Eligibility criteria:
inclusion criteria: * fertile women between 25-44 years old * climacteric women between 45-55 years old exclusion criteria: * inferior age to 25 years old * superior age to 55 years old * post-menopausal * under hormone therapy * thyroid disease * under psychiatric therapy or medication * history for allergies and/or hypersensitivity to any component * breast feeding or pregnancy * no knowledge for writing and/or reading

Keywords: edema depression hot flashes anxiety irritability pms
a study to investigate the effect of inhaling a single dose of gw642444m in copd patients.

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: this study will involve the use of a new compound, gw642444 that is being developed for the treatment of asthma and chronic obstructive pulmonary disease (copd). it works by acting on cells in the lungs, causing some of the muscles around the lungs to relax and open up better (bronchodilation), making breathing easier. when a medicine is made into a form ready to be given to patients, the active ingredient is often prepared in the form of a salt, and inactive ingredients (excipients) are often added. inactive ingredients might be used to help a medicine work better, to make it easier to produce the medicine, or to make it easier to get an accurate dose of medicine. in previous studies the study drug has been given as a dry powder in the form of either the 'h' salt (with the excipient lactose), or in the form of the 'm' salt (with the excipients lactose and cellobiose octaacetate). in this study the 'm' salt form of the study drug has been prepared with lactose and a new excipient called magnesium stearate (instead of cellobiose octaacetate). participants in this study will receive both the 'h' salt (gw642444h) and the new 'm' salt (gw642444m) containing magnesium stearate. this study will be the first time the new 'm' salt form of the study drug will be given to copd patients.


Eligibility criteria:
inclusion criteria: * male or female (of non-childbearing potential) \> or = 40 years * history of copd * smoker or ex-smoker * body weight \> or = 50 kg with bmi 18-32 kg/m2 exclusion criteria: * history of significant disease * subjects with a primary asthma diagnosis * alpha-1 antitrypsin deficiency as underlying cause of copd * recent respiratory tract infection * poorly controlled copd * blood potassium level \< 3.5mmol/l * short-term or long tern oxygen therapy * recent participation in another trial * history of drug or alcohol abuse * known allergies * recent blood donation * ecg abnormalities

Keywords: pharmacodynamics, chronic obstructive pulmonary disease (copd) safety, copd patients pharmacokinetics, tolerability, gw642444,
effects of different exercises interventions in post-menopausal women

Conditions: Hypertension; Menopause

Summary: this study will compare different exercise training protocols on health parameters of postmenopausal women. the hypothesis is that short duration high intensity interval training will promote different effects of long duration moderate intensity training.

exercise load control still not a consensus as to the most effective strategy for improving health parameters in postmenopausal women. in this way, the volunteers will perform anthropometric and body composition assessments, climacteric symptoms and sleep quality evaluations, blood pressure reactivity, resting blood pressure and heart rate and ambulatorial blood pressure monitoring, before and after 12 weeks of training.

Eligibility criteria:
inclusion criteria: * being postmenopausal (amenorrhea of at least 12 months and \[fsh\]\> 40 mlu/ml); be controlled hypertension; not to undergo drug treatment with β-blockers; not make use of sex hormone therapies; do not present physical problems or cardiovascular complications that prevent the performance of physical exercises; present attestation of a cardiologist proving that they are able to perform physical exercises. exclusion criteria: * do not attend the collection site on the day and time programmed more than once in the acute phase of the study; missing more than 2 consecutive sessions or 6 alternates in the chronic phase of the study; unable to perform the proposed training protocols; change in drug therapy during the intervention.

Keywords: blood pressure menopause hypertension exercise alternative training
rfa for small hcc with no-touch technique and dual cooled-wet electrode

Conditions: Carcinoma, Hepatocellular

Summary: the purpose of this study is to prospectively compare the clinical outcomes (local tumor progression rate, technical success rate, complication rate) of no touch radiofrequency ablation (rfa) technique for hepatocellular carcinoma (hcc) to those of conventional tumor puncture rfa technique.


Eligibility criteria:
inclusion criteria: * child-pugh class a * patient with 1-2.5cm sized hcc * 1 or 2 hcc lesions exclusion criteria: * maximum tumor diameter greater than 2.5cm * child-pugh class b or c * more than 3 hcc lesions * invisible tumor even after us/ct or us/mr fusion * presence of vascular tumor thrombosis or extrahepatic metastasis * severe coagulopathy (plt \< 50k, pt \< 50% of normal range)

Keywords: hcc rfa
comparison of morning operation and evening operation on postoperative sleep quality and pain under general anesthesia

Conditions: Morning Operation; Evening Operation; Sleep Quality; General Anesthesia; Circadian Rhythm Sleep Disorder

Summary: general anesthesia is a medically induced state of low reactivity consciousness involving amnesia, immobility, unconsciousness, and analgesia, which is similar to natural sleep. its aim is to create a state of sensory deprivation to induce a lack of motor reaction to stimuli and to obtain an explicit amnesia. some studies found that general anesthesia as an independent risk factor could result in a desynchronization of the circadian time structure and cause postoperative sleep disorders characterized by reduced rapid eye movement (rem) and slow wave sleep (sws), which have signiﬁcant deleterious impacts on postoperative outcomes, such as postoperative fatigue, severe anxiety and depression, emotional detachment and delirium, and even pain sensitivity or postoperative pain of patients.several studies also indicated that circadian rhythms existed in human and controlled by a main internal central clock, the suprachiasmatic nuclei, located in the anterior hypothalamus, which produce and regulate biological rhythms such as sleep arousal, hormones and metabolism could also affect the dose of general anesthesics, which lead to different postoperative recoveries and may have different effects on postoperative sleep quality. previous studies proved that postoperative sleep disturbances and poor sleep quality are associated with higher postoperative pain, changes in behavior and poor emotional well-being, which could further aggravate postoperative sleep quality. at present, there are few studies which are about the effect of circadian rhythm for different timing of surgery on intraoperative anesthestic requirement, postoperative sleep quality and pain under general anesthesia.

eighty-four patients scheduled for elective laparoscopic abdominal surgeries under general anesthesia were randomly assigned to receive operation in the day group (8:00-12:00) and the night group (18:00-22:00). the portable sleep monitor (psm) was performed on the following 3 nights: the night before surgery (sleep1), the ﬁrst night after surgery (sleep 2), and the third night after surgery (sleep 3). postoperative pain scores using visual analogue scoring scale, subjective sleep quality using the athens insomnia scale, total dose of general anesthetics and postoperative adverse effect were also recorded

Eligibility criteria:
inclusion criteria: * age between 18 and 65 years * american society of anaesthesiologists (asa) physical status i or ii. exclusion criteria: * cardiovascular disease * long term use of analgesic * preoperative heart rate (hr) less than 50 beats/min * second- or third-degree atrioventricular block * sleep disorder * sleep apnea syndrome * history of abnormal operation or anesthesia recovery psychosis or a patient with a language communication disorder did not provide informed consent

Keywords: morning operation evening operation sleep quality general anesthesia circadian rhythm
evaluation of improvement in mobility skills for sub-acute stroke patients, using the selfit system.

Conditions: Stroke

Summary: stroke is a leading cause of mobility disability for adults. selfit is an advanced practice system that enables a wide range of exercises to improve patient mobility in the sub-acute stage after a stroke. the system collects, measures and analyzes the patient's activity in practice.

objectives of the study: an evaluation of the improvement of mobility after a stroke using the selfit system. type of study: case control study. study population: 30 patients, after stroke (men and women aged 18-85). criteria for inclusion: stroke patients who are capable to walk with a little help or no help at all, with or without any assitive device, for a distance of 10 meters. intervention: random distribution of the study participants into two groups - case: stroke patients (15 patients) - evaluation of patients using selfit for 2 sessions per week, for a period of at least 30 minutes per session, during 3 weeks. control: stroke patients (15 patients) - continuing with current therapy with no use of the selfit system. measurement tools and outcome measures: duration of each treatment session, the duration of the actual treatment, the number of technical failures in the system during the exercise and the duration of each session will be recorded. at the end of the intervention, questionnaires describing the experience of using the system will be completed with a rating of the degree of satisfaction, convenience and simplicity of using the selfit system. the following tests will be carried out : 10 meter walk test, timed up and go test, dynamic gait index (dgi). analysis of the data: for each patient's treatment, a personal activity profile will be established that includes the timing and speed of walking, the number of steps, the length and width of each step, the elevation of the leg at each step and the accuracy of the patient's performance. statistical analysis will examine the various levels of activity throughout the intervention period for each patient and for the entire study population before and after the intervention. at the same time, the correlation between the level of activity in the treatment and the scores on the neurological tests will be examined. the data will be presented descriptively for the therapist and patient. for statistical analysis, the spps version 21 (ibm) will be used.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of stroke .must walk with little or no help at all, with or without an assistive device, for a distance of at least 10 meters. exclusion criteria: - .patients suffering from significant lower back pain and / or previous orthopedic impairment and / or cognitive impairment (grade 18 and below according to the moca test). .patients who are unable to move with little or no help at all, with or without an assistive device, for a distance of 10 meters.

Keywords: stroke sub-acute mobility movement therapy exercise
analgesic effect of adding thoracic paravertebral nerve blocks to modified pec block in breast cancer surgery

Conditions: Breast Cancer Female; Pain, Postoperative

Summary: to compare efficacy and safety of adding thoracic paravertebral nerve blocks to modified pec block versus modified pec block only in breast cancer surgery. this study evaluate systemic opioid requirement in 48 hours in primary outcome and the analgesic profile ( pain score at rest and on shoulder movement), opioid-related side effects and nerve blocks complications.

regional anesthesia has been used and studied extensively in breast surgery as an opioid-sparing strategy, with block of the intercostal supply by thoracic paravertebral block (tpvb) becoming a popular technique. this prospective randomized controlled trial is aimed to study the proper regional nerve block technique to reach the postoperative opioid-free requirement modality for breast cancer surgery.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) grade i-iii * aged ≥ 18-80 years old * elective unilateral total mastectomy with sentinel lymph node biopsy or lymph node dissection exclusion criteria: * patient refusal * language barrier or inability to communicate with the operating team * allergy to local anesthetic * bleeding disorder * previous breast surgery or thoracic radiation therapy * bmi ≥ 30 * patient who can not understand the proper use of intravenous patient-controlled analgesia machine or who has the problem with communication * chronic pain patient

Keywords: postoperative pain thoracic paravertebral block modified pec block breast cancer total mastectomy with sentinel lymph node clearance
study evaluating tigecycline in selected serious infections caused by vancomycin-resistant enterococcus (vre) or methicillin-resistant staphylococcus aureus (mrsa)

Conditions: Gram-Positive Bacterial Infections; Staphylococcus Infections; Vancomycin Resistance; Methicillin Resistance

Summary: to evaluate the safety and efficacy of tigecycline in the treatment of selected serious infections caused by vre. the primary efficacy endpoint will be the clinical response for all subjects.


Eligibility criteria:
inclusion criteria: * male or female subjects aged 18 years or older * isolation of one of the following multi-antibiotic resistant bacteria: vancomycin-resistant enterococcus faecium, vancomycin-resistant enterococcus faecalis, or methicillin-resistant staphylococcus aureus, alone or as part of a polymicrobial infection * have a confirmed diagnosis of a serious infection (eg, bacteremia \[unless due to an excluded infection\], complicated intra-abdominal infection, complicated skin and skin structure infection, or pneumonia) requiring administration of intravenous (iv) antibiotic therapy exclusion criteria: * subjects with any concomitant condition or taking any concomitant medication that, in the opinion of the investigator, could preclude an evaluation of a response or make it unlikely that the contemplated course of therapy or follow-up assessment will be completed or that will substantially increase the risk associated with the subject's participation in this study * anticipated length of antibiotic therapy less than 7 days * for subjects with vre, known or suspected hypersensitivity to tigecycline or linezolid, or other compounds related to these classes of antibacterial agents (eg, oxazolidinones, tetracyclines, minocycline, doxycycline). for subjects with mrsa, known or suspected hypersensitivity to tigecycline or vancomycin, or other compounds related to these classes of antibacterial agents (eg, tetracyclines, minocycline, doxycycline)

Keywords: staphylococcus aureus bacterial infections
cost of failure following reimplantation after a 2-stage exchange strategy for hip or knee prosthetic joint infection

Conditions: Prosthetic Joint Infection

Summary: this study concerns patients having had an infection on their prosthesis (hip, knee,..) and for whom a 2-step exchange of prosthesis has been done. a 2-step exchange consists in explantation of the prosthesis and implementation of a spacer at the first stage, and reimplantation of a new prosthesis in a second stage. patients with late prosthetic joint infection are at risk for superinfection at the time of reimplantation. the aim of this study is to determine the global cost of management of prosthetic joint infection.


Eligibility criteria:
inclusion criteria: * patients with prosthetic joint infection having had a 2-step exchange and managed at the crioac from at least the reimplantation (between 2013 and 2015) exclusion criteria: -

Keywords: prosthetic joint infection
androgen metabolism and reproductive outcome

Conditions: Polycystic Ovary Syndrome; Healthy Pregnant Women

Summary: the aim of this study is to determine maternal androgen metabolism during pregnancy and the impact of androgen disorders on mothers and infants.

women with polycystic ovary syndrome (pcos) have an impaired fertility and significant higher complication rates during infertility treatment, pregnancy and the perinatal period. complications include the occurrence of multiple gestations, ovarian hyper stimulation syndrome, early pregnancy loss, gestational diabetes, pregnancy-induced hypertension, pre-eclampsia and need for caesarean section. moreover, their infants are more frequently born preterm, have higher perinatal mortality rates and are more often admitted to a neonatal intensive care unit. the etiology of pcos is not particularly mapped, but a genetic background can be assumed by analyzing pcos families. in utero androgen excess has also been suspected to be an important risk factor. animal studies have demonstrated that intrauterine hyperandrogenic environment affects the offspring by leading to biochemical and morphological features of pcos. sex differences in prenatal androgen levels have been observed and testosterone levels in umbilical cord blood and in amniotic fluid are higher in healthy male babies than in healthy female babies. there are just a few reporting on the relation between maternal androgen levels during pregnancy and the respective offspring. the aim of this clinical study is to determine maternal androgen metabolism and the impact of androgen disorders on mothers and infants.

Eligibility criteria:
inclusion criteria: * pregnant women with and without pcos exclusion criteria: * unable to consent

Keywords: polycystic ovary syndrome hyperandrogenism cordblood androgens