Kornimate/medical-research-clean huggingface dataset:
prognostic interest of vasorin in septic shock

Conditions: Sepsis; Acute Kidney Injury

Summary: in septic shock, the intensity and duration of low blood pressure can lead to a critical reduction in renal tissue perfusion and lead to the onset of more or less severe acute kidney injury (aki). vasorin (vasn) is a protein strongly expressed in large vessels and kidneys, whose functions are still poorly known. previous experimental studies show that vasn is associated with decreased angiotensin ii concentrations, a vessel contractility defect and early mortality. the investigators hypothesize that vasn (the potential direct regulator of blood pressure) would be an early biomarker predicting the severity of aki post septic shock, which may be associated with mortality from septic shock or lead to longer-term chronic renal failure (ckd).


Eligibility criteria:
inclusion criteria: * age ≥18 years old. * hospitalized in intensive care or medical resuscitation units. * with a septic shock state defined by 2 mmol/l lactate sepsis, requiring vasopressors to maintain mean blood pressure 65 mmhg (despite adequate vascular filling). * whether or not they have developed aki. * patient/family information and collection of non opposition exclusion criteria: * patients with chronic respiratory failure. * pregnant women. * patients in palliative care. * information for the patient/someone close and collection of his opposition

Keywords: vasorin sepsis angiotensin ii acute kidney injury
clinical effects and cost-effectiveness analysis of early anti-viral therapy on hbv-related compensated liver cirrhosis

Conditions: Liver Cirrhosis; Hepatitis B

Summary: though newly reported hbv infection and hbsag prevalence in china have greatly decreased, patients who had been chronically infected with hbv, especially those with liver cirrhosis cause great burden on public health care. in view of economic development level, drug availability and lack of independent health economics evidence, the investigators are still unable to give specific guidelines for hbv related compensated liver cirrhosis in china. therefore, the investigators aim to investigate clinical effects and cost-effectiveness of two early anti-viral therapy strategies on hbv related compensated liver cirrhosis through this prospective, open-label, multicenter and nonrandomized study.


Eligibility criteria:
inclusion criteria: * written informed consent * aged 18-70 years * clinical diagnosis of compensated liver cirrhosis 1. liver biopsy showing cirrhosis 2. endoscopy: esophageal varices , exclusion of noncirrhotic portal hypertension 3. if no biopsy or endoscopy ，should meet two of the four: * imaging(us, ct or mri, et al) showing surface nodularity： echogenecity （spleen pachydiameter \> 4.0cm or\> 5 costal region） * plt \ /l，no other interpretation * alb \ 1.3, or che \< 5.0ku/l * liver stiffness measurement value \> 12.4 kpa * hbeag(+)with hbvdna \> 10 \ iu/ml or hbeag(-) wtih hbvdna \> 102 iu/ml exclusion criteria: * patient with decompensated liver cirrhosis:presence of ascites, variceal hemorrhage,hepatic encephalopathy * allergic to any ingredients of the drugs * patient complicated with alcoholic liver disease, autoimmune liver disease, heretic liver disease, drug induced liver disease,nonalcoholic liver disease or other chronic liver disease. * afp \> 100ng/ml or cr \> 1.5×uln * pregnant woman * patient with severe disease or other organ failure * patient with any tumors * patient with sever mental disease. * patients with any disease or condition which the investigator or treating physician feels would interfere with the trial or the safety of the subject

Keywords: compensated liver cirrhosis early antiviral therapy cost effectiveness
changes in quadriceps muscular activity in patients after total knee arthroplasty compared to healty subjects

Conditions: Arthroplasty, Knee Replacement; Musculoskeletal Disorder

Summary: during total knee arthroplasty (tka), joint undergo considerable stress, which causes neuromuscular activation deficits of the quadriceps femoris muscle.the aim of the study is to investigate differences in quadriceps neuromuscular activity in the acute phase after surgery.

during total knee arthroplasty (tka), joint undergo considerable stress, which causes neuromuscular activation deficits of the quadriceps femoris muscle. the current phenomenon depends on a complex mechanism called arthrogenic muscle inhibition (ami). ami has been studied only in sub-acute and chronic phase after tka due to the invasive procedures employed in order to evaluate it; however, clinical observation and experimental studies suggest presence of this phenomenon also in the first postoperative days. the aim of the study is to investigate differences in quadriceps neuromuscular activity, in acute phase. the study is a prospective observational study.15 healthy subjects and 15 patients scheduled for tka will be recruited. patients will be asked to perform three isokinetic taks in the same standardized biomechanical context in order to evaluate changes in quadriceps neuromuscular activity after surgery as primary outcome. secondly, correlation between primary aim and pain perceived by the patient will be investigated. moreover, patient's functional ability will be assessed using the timed up and go test (tug). data will be recorded the day before tka, at one and three days after surgery. at the end of data acquisition, normality and homogeneity of demographic variables will be assessed. differences in the outcome measures will be investigated with the t student test (or with the related non-parametric tests) and by means of the mixed models repeated measures anova test. linear regression will be applied to evaluate any correlation between outcomes.

Eligibility criteria:
inclusion criteria: * age: over 18 years. * subjects eligible for tka. exclusion criteria: * qab (quadriceps activation battery) \< 6 the day before the operation * neurological or musculoskeletal diseases (different from the causes that which led the patient to the tka), which may interfere with the quadriceps muscle activation or with motor performance of the subject. * uncooperative subjects.
interference with cognitive control by transcranial direct current stimulation

Conditions: Depression

Summary: insufficient cognitive control over emotional distracters is characteristic for major depressive disorder (mdd). hypoactivation of the dorsolateral prefrontal cortex (dlpfc) is associated with this deficit. in this study the investigators assess the effect of a decrease of dlpfc activity in healthy subjects by cathodal transcranial direct current stimulation (tdcs) on cognitive control. in a double-blinded, balanced randomized, sham-controlled crossover trial the investigators determine the effect of a single-session of cathodal tdcs to the left dlpfc on cognitive control in healthy subjects. to assess the cognitive control the investigators use a delayed response working memory task (dwm)and an arithmetic inhibition task (ait) with pictures of varying valence.


Eligibility criteria:
inclusion criteria: informed consent exclusion criteria: psychiatric or neurological disorders seizures cardiac pacemakers
can virtual reality technology improve the patient experience in oocyte retrieval?

Conditions: Infertility, Female

Summary: a non-pharmacological, non-blinded, randomized cohort study that will investigate the effect of virtual reality technology on the patient experience during oocyte retrieval. the primary objective of the trial is to investigate the impact of virtual reality technology on the patient experience


Eligibility criteria:
inclusion criteria: * women undergoing oocyte retrieval * understanding and speaking danish exclusion criteria: * previous participation in the trial * acupuncture as pain relief during oocyte retrieval

Keywords: infertility virtual reality
comparing aloe vera gel and rosemary oil in pressure injury prevention

Conditions: Pressure Injury

Summary: most patients admitted to the orthopedic ward are at risk of developing pressure ulcers. today, the tendency to use medicinal herbs in pressure ulcer treatment has increased due to the variety of effective compounds and their fewer side effects.

aloe vera is medicinal plant that has been used to treat skin problems since 1500 bc many studies have shown that using aloe vera to treat various wounds such as psoriasis, mouth ulcers, diabetic ulcers herpes and bed sores has had positive effects. in addition, rosemary has therapeutic properties and has been used in the folk medicine, pharmaceutical, and cosmetics industries, mainly for its antioxidant, anti-inflammatory and vasodilatation properties, which are attributed to the presence of carnosol/carnosic and ursolic acids. besides it therapeutic uses, rosemary has potential applications in cosmetic formulations and in the treatment of pathological and non-pathological conditions, such as cellulite, alopecia, ultraviolet damage, and aging.

Eligibility criteria:
inclusion criteria: * willingness to participate in research, lack of skin diseases (such as psoriasis, fungal illness, freckles), patients that are at risk of moderate to severe bedsores according to nursing diagnosis and braden scoring tool and scored less than 13-14; the absence of pi on admission; the probability of length of stay should be above 10 days exclusion criteria: * a decrease in hemoglobin levels during the study to lower than 12 in men and less than 10 mg/dl in women, anemia, hyperthermia during the study and sensitivity to aloe vera or rosemary.
endobiliary radiofrequency ablation with s-1 for unresectable cholangiocarcinoma

Conditions: Cholangiocarcinoma

Summary: endobiliary radiofrequency ablation (rfa) with biliary stent has been reported to be a beneficial treatment option for palliation of malignant biliary strictures. rfa uses a high-frequency alternating current to generate heat and achieve coagulative necrosis when in contact with tissue. within the bile duct, rfa appears to be safe and may result in decreased tumor ingrowth. however, most of therapeutic effects were expected to delay bile duct obstruction rather than to decrease the tumor. recently orally available chemotherapeutic agent, s-1, an oral fluoropyrimidine, was reported as effective in patients with bile duct adenocarcinoma. to date, little is known about the role of the addition of systemic chemotherapy to rfa for cholangiocarcinoma. the aim of this study is to evaluate the combined effect of rfa and s-1 in patients with unresectable cholangiocarcinoma.

over 60 % of common bile duct (cbd) obstructions are due to malignancy, and the majority of neoplasms are unresectable at the time of diagnosis. biliary drainage with placement of metal or plastic stents for palliation is the therapy of choice in this set of patients. radiofrequency ablation (rfa) is well established method for treatment of some solid tumors, like liver cancer, lung cancer, etc. recently, an endoscopically applicable radiofrequency probe, habibtm endohbp catheter, was approved for clinical use. rfa uses a high-frequency alternating current to generate heat and achieve coagulative necrosis when in contact with tissue. many studies showed rfa with biliary stent was a beneficial treatment option for palliation of malignant biliary strictures. however, most of therapeutic effects were expected to delay bile duct obstruction rather than to decrease the tumor. recently orally available chemotherapeutic agent, s-1, an oral fluoropyrimidine, was reported as effective in patients with bile duct adenocarcinoma. to date, little is known about the role of the addition of systemic chemotherapy to rfa for cholangiocarcinoma. the aim of this study is to conduct a randomised, controlled, clinical trial to compare the effect of s-1 plus rfa with stent with rfa with stent in patients with unresectable cholangiocarcinoma.

Eligibility criteria:
inclusion criteria: * obtention of a written informed consent. * patient over 18. * patient with histologically proved cholangiocarcinoma ; histologic diagnosis must be proved by biliary brushing, bile cytology, endobiliary biopsy under spyglass, or by eus-fna. * patient with karnofsky score ≥ 50 % * patient capable of fill in the quality of life questionnaire. exclusion criteria: * no written informed consent. * patients under or already treated by radiotherapy or chemotherapy treatment for cholangiocarcinoma. * patients with porphyria or hypersensibility to porphyrins. * pregnant, parturient or breastfeeding women. * patient under 18.

Keywords: biliary duct carcinoma; radiofrequency ablation s-1
transcrestal lateral sinus floor elevation in implant therapy

Conditions: Edentulous; Alveolar Process, Atrophy

Summary: this is a non-inferiority study to evaluate whether l-prf achieves similar or perhaps better results in bone gain, compared with "the golden standard" dbbm, after trans-crestal sinus floor elevation.

this is a randomized controlled clinical trial with parallel group design. a total of 40 patients, needing transcrestal sinus lift (t), will be enrolled. under local anesthesia, the required t and implant placement will be performed and isq values will be recorded. afterwards a cbct will be taken for control. randomization will be performed by computer generated random codes, using random permuted blocks with a block size of 4 to avoid uneven splits and minimization for the key prognostic factors rbh. allocation will be concealed to the surgeons at completion of the common part of treatment, by opening an opaque envelope. at the same time an oral implant(s) will be inserted in the augmented area. after 6 months a cbct will be taken for control of the bone healing and the measurements of the newly formed bone. the abutment will be placed on top of the osseo-integrated implant(s) under local anesthesia. isq values will be recorded. follow-up will be till 1 year.

Eligibility criteria:
inclusion criteria: * provision of informed consent * need for t and oral implant placement. * rbh \>3mm exclusion criteria: * unlikely to be able to comply with the study procedures, as judged by the investigator * untreated periodontal disease * unfavorable plaque control * known or suspected current malignancy * history of chemotherapy within 5y prior to study * history of radiation on the head and neck region * history of other metabolic bone diseases * need for systemic corticosteroids * current or previous use of intravenous/oral bisphosphonates * present alcohol and/or drug abuse * involvement in the planning and conduct of the study * psychiatric disorders which do not allow a normal treatment outcome
cor adv flap plus ac derm matrix in thin phenotype multiple recessions

Conditions: Gingival Recession, Generalized

Summary: clinical evaluation of conventional and modified coronally advanced flaps combined with acellular dermal matrix graft

the aim of this study was to evaluate the effectiveness of vertical incisions in the management of multiple gingival recessions (miller class i\&ii ≥3 mm) treated with coronally advanced flap (caf) and acellular dermal matrix graft (admg) in 22 eligible participants.

Eligibility criteria:
inclusion criteria: * systemically healthy patients * miller class i \& ii multiple buccal recession defects ≥ 3 mm on maxillary incisors, canines or premolars * esthetic indication for root coverage * probing depth \< 3mm at the recession sites exclusion criteria: * smokers * pregnancy * bruxism and occlusal trauma * previous root coverage procedure * endodontically treated teeth at the recession sites * caries or restorations at the recession sites * use of antibiotics over the previous 3 months prior to treatment

Keywords: gingival recession therapy surgery tooth root surgical flaps acellular dermis
effect of routine physical therapy with and without core stability exercises in patients with lumbar radiculopathy

Conditions: Lumbar Radiculopathy

Summary: the goal of this randomized controlled trial was to examine the effect of routine physical therapy with and without core stability exercises in patients with lumbar radiculopathy. the main question it aims to answer is: • to examine the effect of routine physical therapy with and without core stability exercises in patients with lumbar radiculopathy participants after reading and signing the consent form were included in study according to eligibility criteria and were allocated in to 2 groups, the standard physical therapy treatment along with core strengthening exercises. core strengthening exercises were carried out in their respective standard positions (were modified according to patient's comfortability). we measured outcome through different outcome measure tools.

lumbar radiculopathy (lr) is defined as spinal nerve-related symptoms such as back and leg pain, with variable presence of paraesthesias, reflex changes, and secondary interference of normal activities. lumbar radiculopathy (lr) is a common debilitating condition of lumbar origin which influences both the general population and athletes alike. its prevalence has been estimated to be 3-5% of the population, affecting both men and women. core strengthening exercises (cse) are used to train, strengthen and condition the core muscles surrounding the middle of the body i.e. the abdomen, hips, pelvis and lower back. cse trains muscle activity patterns without unnecessarily overloading the tissue, and can help to stabilize the spine. core strengthening exercises were applied on patient with lumbar radiculopathy and calf pain to see whether it helps to reduce pain or not. participants were given consent form and after subjects read and sign the informed consent, they were included in study according to eligibility criteria. 2 groups were included in study, the standard physical therapy treatment along with core strengthening exercises. core strengthening exercises were carried out in their respective standard positions (were modified according to patient's comfortability). we measured outcome through different outcome measure tools.

Eligibility criteria:
inclusion criteria: * 45-65 years both genders * low back pain radiating towards calf for more than 2 months (diagnosed by the orthopedic surgeon) exclusion criteria: * patients with inflammatory, infectious, malign or metabolic diseases * patients with osteoporosis, neurological defects, calf muscle hypertrophy, cardiovascular disorders any spinal or leg operations * pregnancy any traumatic history
the effects of gonadotropin replacement therapy in patients with hypogonadism

Conditions: Idiopathic Hypogonadotropic Hypogonadism

Summary: effects of hcg replacement therapy on metabolic syndrome parameters in hypogonadotrophic hypogonadism.


Eligibility criteria:
inclusion criteria: serum testosterone concentration \< 300ng/dl absence of a pituitary or hypothalamic mass lesions, presence of gonadotropin response to gnrh, - exclusion criteria: previous androgen treatment, diabetes mellitus, arterial hypertension other hormone deficiencies -
a pilot study of pulmonary function in dysphagic infants

Conditions: Chronic Lung Disease

Summary: infants less than 2 years old who have been newly diagnosed with problems swallowing will have pulmonary function tests performed to try to detect the presence of chronic lung disease. six months later after the infants have received appropriate therapy for their swallowing problems, pulmonary function tests will be performed again to see if there has been any change in their chronic lung disease.

twenty-five infants between the ages of 1 month and 24 months who have just been diagnosed with dysphagia via a modified barium feeding study will be recruited into the study. the infants will be sedated with chloral hydrate and have pulmonary functions measured (pre- and post-bronchodilator spirometry and lung volume) using the infant pulmonary laboratory. treatment for the infants' dysphagia/chronic aspiration will be treated as determined by the primary care physicians. six months later the infants will again be sedated and have pulmonary functions measured. results of the two sets of tests will be compared statistically.

Eligibility criteria:
inclusion criteria: * infants between ages 1-24 months who have been newly diagnosed with dysphagia exclusion criteria: * cystic fibrosis * obstructive sleep apnea * seizures * allergy or adverse reaction to chloral hydrate * heart disease * liver disease * kidney disease * pneumonia * pleural effusion * neuromuscular disease * major congenital anomalies * tracheoesophageal fistula * vascular ring * bronchopulmonary dysplasia * pharyngeal anomalies * arnold-chiari malformation

Keywords: pulmonary function tests infants chronic lung disease dysphagia chronic aspiration
comprehensive review of retinal pseudo-holes: clinical presentation, diagnosis, pathophysiology, and management

Conditions: Epiretinal Membrane; Age-related Disease; Idiopathic ERM

Summary: retinal pseudo-holes (rph) are macular abnormalities that mimic macular holes (mh) but lack full-thickness retinal disruption. this systematic review, based on 35 studies, explores their clinical presentation, diagnosis, pathophysiology, and management. diagnosis: differentiating rph from mh is challenging due to overlapping symptoms such as central scotomas and visual distortion. optical coherence tomography (oct) has become the gold standard for diagnosis, surpassing older imaging techniques like fundus photography and fluorescein angiography. oct provides detailed, non-invasive imaging that helps identify rph's hallmark feature: a foveal depression without retinal break. pathophysiology: rph is primarily caused by mechanical forces exerted on the macula by epiretinal membranes (erm) and vitreomacular traction (vmt). these forces distort the retina, creating a pseudo-hole. risk factors include aging, high myopia, trauma, and diabetes. management: many rph cases are managed conservatively with regular monitoring, as the condition often remains stable. surgical intervention, such as pars plana vitrectomy (ppv) with membrane peeling, is reserved for symptomatic cases with significant visual impairment. surgery has shown promising outcomes, with most patients experiencing improved visual acuity. research needs: further studies are needed to explore the long-term outcomes of rph, identify factors predicting progression to mh, and assess the utility of advanced imaging techniques like oct angiography in improving diagnosis and monitoring. this review underscores the importance of accurate differentiation between rph and mh to ensure appropriate management and avoid unnecessary treatments.

this is a review study on retinal pseudo-holes.

Eligibility criteria:
inclusion criteria: * studies that directly addressed retinal pseudo-holes, their clinical presentation, diagnostic modalities, pathophysiology, or treatment. * peer-reviewed clinical trials, case reports, observational studies, and reviews. * studies that utilized oct or other imaging techniques (such as fluorescein angiography or fundus photography) to diagnose retinal pseudo-holes. * studies that were published in english and provided full-text access. exclusion criteria: * studies that did not specifically focus on retinal pseudo-holes but instead dealt with other retinal conditions (e.g., full-thickness macular holes, retinal detachment). * studies that were not peer-reviewed (e.g., conference abstracts, opinion pieces). * non-english language studies or those without available full texts.