a natural history study of bone and mineral disorders

Conditions: Tumor Induced Osteomalcia; Osteomalacia; Familial Tumoral Calcinosis

Summary: this study has four objectives: 1) to provide investigators the opportunity to study bone specimens from patients with various skeletal diseases; 2) to treat patients with skeletal diseases at the nih; 3) to expose nih trainees to certain skeletal diseases; and 4) to gain more knowledge about skeletal diseases and stimulate further study of bone biology. anyone with a disease that affects the skeleton may be eligible for this study. all evaluations, tests, procedures and treatments given study participants are used in the standard care of skeletal diseases. no experimental evaluations or treatments are offered. patient evaluations include a medical history, review of medical records and routine physical examination. based on the findings, other procedures may be recommended, including blood tests, urine tests, and imaging tests, such as x-rays, bone densitometry, bone scan, computed tomography (ct) and magnetic resonance imaging (mri). bone specimens from participants will be collected for research use. specimens will be obtained from bone removed during a patient s planned surgical procedure performed for medical care, or patients may be requested to have a bone biopsy removal of a small piece of bone tissue as part of the patient evaluation procedure.

study description: to evaluate participants with bone and mineral disorders at the nih clinical center and obtain tissue and clinical specimens from outside institutions objectives: primary objective: provide a protocol within which participants with common and rare disorders of bone and mineral metabolism can be studied, evaluated and treated at nih. secondary objectives: to obtain tissue and clinical specimens (including but not limited to blood, urine, nucleic acids, skin and bone) and data collected at outside institutions and the nih clinical center from participants with various bone and mineral disorders. tertiary/exploratory objective: generate a pool of participants with bone and mineral disorders, from which research questions could arise and future clinical research studies may be generated. endpoints: primary endpoint: medical evaluation with clinical assessments performed at time points specific to each participant s diagnosis. analysis of research and participant outcome data will be performed. secondary endpoint: genetic and/or biochemical assessments of surgical waste material from the nih clinical center or other medical facilities. tertiary/exploratory endpoint: development of a database containing information from enrolled participants with bone and mineral disorders and annotated specimens and data.

Eligibility criteria:
* inclusion criteria: the study population will include participants with known or suspected bone disease and/or with a known or suspected disorder of mineral metabolism. to be eligible to participate in this study, an individual must meet all of the following criteria: 1. age 1 day of life or older 2. have a known or suspected bone disease, as demonstrated by any one of the following: a fracture, or abnormal bone findings on x-ray, ct scan, mri, or bone densitometry, and/or a medical or family history consistent with or suggestive of a bone disease. 3. have a known or suspected disorder of mineral metabolism, as demonstrated by any one of the following: laboratory measurement above or below the reference values for either blood or urine calcium, phosphorus, magnesium, parathyroid hormone or vitamin d, or other measures of mineral metabolism, and/or a medical or family history consistent with or suggestive of a disorder of mineral metabolism. exclusion criteria: 1. participants unwilling or unable to abide by procedures of protocol.

Keywords: natural history skeletal diseases osteoporosis dysplasia osteomalacia bone diseases skeletal disease