Kornimate/medical-research-clean huggingface dataset:
retrovertion assesment and study in elderly patients with reverse total shoulder arthroplasty

Conditions: Rotator Cuff Tears; Rotator Cuff Tear Arthropathy

Summary: determine the optimal degree of retroversion (0-30º) to obtain the best rotational mobility, both internal and external, of the shoulder after implanting a reversed sghoulder arthroplasty (comprehensive system), and analyze the functional and radiologic results based on humeral retroversion.

methodology: open randomized controlled clinical trial. it will be carried out with patients operated with reverse shoulder arthroplasty (at 0º and 30º of humeral retroversion) included consecutively in terrassa hospital from january 2019 to june 2021. the estimated sample will be 30 patients per group with diagnosis of massive rotator cuff rupture, rotator cuff arthropaty and primary osteoarthritis with cuff injury, with walch's type b2 glena or in patients older than 80 years. a global study will be carried out preoperatively and postoperatively with radiographs, computerized tomography, magnetic resonance, and a biomechanical study.

Eligibility criteria:
inclusion criteria: * men and women over 60 with the diagnosis rotator cuff massive break (hamada 2 or more), arthrosis secondary to ruptures of the rotator cuff and primary osteoarthritis with lesion of the cuff, with full walch b2 type or in patients older than 80 years. inclusion criteria * good functionality of the deltoid muscle. * presence of minor round (hornblower test - no muscle atrophy in nuclear magnetic resonance) * accept informed consent exclusion criteria: * - review of hemiarthroplasty or anatomical proesis of the affected shoulder. * fracture of shoulder in the upper extremity to intervene. * central neurological diseases * advanced cognitive impairment * brachial plexus injuries * local or systemic infection. * oncological disease * treatment with immunosuppressants.
comparative effects of mime therapy and action observation therapy in bell's palsy

Conditions: Bell Palsy

Summary: the aim of this study is to determine comparative effects of mime therapy and action observation therapy on facial symmetry and quality of life in bell's palsy. bell's palsy is characterized as an abrupt paralysis of the peripheral facial nerve, typically without a known cause. mime therapy is a performing technique that helps patients regain the ability to use their face muscles. action observation therapy is novel rehabilitation approach exploiting this mirror mechanism.

this randomized clinical trial will be conducted at sir ganga ram hospital in 7 months. 62 participants with bell's palsy will be included as per sample size calculation through convenience sampling technique. participants which meet inclusion criteria will be randomly allocated using online randomization tool into two groups. group a will receive mime therapy for 30 minutes with short resting interval and group b will receive action observation therapy for 30 minutes. each group will receive treatment session of 5 days per week for 6 weeks. facial symmetry will be measured using the 13-item sunny brook facial grading system, facial disability index will be used to assess the quality of life and the house-brackmann facial nerve grading system will be used to characterize the degree of facial paralysis. the data will be analyzed using spss version 24 for windows software.

Eligibility criteria:
inclusion criteria: 1. bell's palsy with acute onset of 1-3 weeks. 2. unilateral loss of facial weakness. 3. patients with intact taste sensation. 4. bell's palsy of house brackmann grade 3 and 4. 5. idiopathic bell's palsy. exclusion criteria: 1. history of facial palsy recurrence. 2. stroke associated bells palsy. 3. history of pregnancy 4. subjects with any disability, fracture, or tumor. 5. history of facial surgery. 6. subject having skin allergy on face.

Keywords: bell palsy breathing exercise comparative mime protocol randomized clinical trial
efficacy comparison of two preoperative skin antisepsis preparations in colorectal surgery

Conditions: Colorectal Surgery

Summary: surgical site infections (ssi) are one of the most common complications in the post-operative patient, and the second most common health care associated infection overall. it is estimated that there are between 500 thousand and 1.1 million surgical site infections in the united states each year. given the magnitude of the problem, prevention of surgical site infections is a major goal of peri-operative care. however, skin preparation prior to surgery has not been as rigorously examined. the primary objective of this study is to compare the efficacy of two fda approved, popular peri-operative skin preparations 2% chlorhexidine gluconate / 70% isopropyl alcohol to iodine povacrylex \[0.7% available iodine\] / 74% isopropyl alcohol in the prevention of superficial surgical site infection. male and female patients, age 18 years and older undergoing elective colorectal surgical procedures involving a laparotomy will be enrolled. these patients are at high risk of ssi. eligible patients will be assessed at regular intervals for ssi and characterization of bacterial pathogen(s) in patients with ssi. patients will remain enrolled into the study until 35 days postoperatively.


Eligibility criteria:
inclusion criteria: 1. 18 years or older, male or female 2. undergoing any large bowel procedure with an extraction incision site(including ileostomy closure and hartman's colostomy reversals). 3. a clean-contaminated preoperative classification. 4. patient must have decision-making capacity and undergo appropriate informed consent process. 5. non-pregnant or post menopausal or surgically sterilized females. if of child-bearing age, patients must have a negative (serum or urine) pregnancy prior to surgery. exclusion criteria: 1. antibiotics taken within 5 days prior to surgery. 2. infected wound classification. 3. preoperative evaluation that may preclude full closure of the skin. 4. undergoing any bowel procedure that will not result in an extraction incision. 5. ongoing radiation or chemotherapy treatment. 6. pregnant. 7. refusal to accept medically indicated blood products. 8. current abdominal wall infection or surgical site infection from previous laparotomy / laparoscopy. 9. history of laparotomy within the last 60 days. 10. known allergy to iodine or to chlorhexidine gluconate. 11. participating in a preoperative antibiotic trial. 12. participating in a skin antisepsis trial. 13. participating in ulcerative colitis trial conflicting with this trial. 14. women who are breast feeding (potential for transient hypothyroidism in the nursing newborn).

Keywords: undergoing elective colon and /or rectal surgical procedures involving an abdominal incision
transcranial ultrasonic stimulation in treatment-resistant depression : an open-label pilot trial

Conditions: Treatment Resistant Depression

Summary: the primary objective of this study is to optimize the protocol for the tus administration in patients with trd while gaining an initial impression of treatment efficacy.


Eligibility criteria:
inclusion criteria: * age between 18 and 75 years, * diagnosis of major depressive episode (mde) as part of major depressive disorder as defined by dsm-5 criteria * severe mde (hdrs-17\> 20) * drug resistance to at least two well-conducted antidepressant treatment lines * with stable antidepressant treatment for at least 4 weeks before inclusion * benefiting from a social security scheme * having given their consent to participate exclusion criteria: * psychiatric history other than a mood disorder * neurological history, including epilepsy and intracerebral calcifications * history of substance use disorder other than tobacco * contraindication to brain mri (pacemaker, neurostimulator, injury from metallic shine, ...) * compulsory psychiatric care * protected adults, people under legal safeguard * pregnant or breastfeeding woman * women of childbearing age who do not have a negative pregnancy test and are not using contraception
the effect of post-extraction collagen sponge application on alveolar osteitis

Conditions: Alveolar Osteitis

Summary: the goal of this randomized controlled trial is to compare pain, mouth opening, and alveolar osteitis following surgical extraction of bilateral symmetrical impacted lower third molars using two types of wound closures. collagen plugs will be applied in the sockets of the study side followed by suture, while the controlled side will be sutured without a collagen plug. the study will include 40 patients aged between 18- 40 years old, medically fit (asa1), who have bilateral symmetrical impacted lower third molars and visit the oral surgery clinics of king saud medical city for extraction. the main question is" does intra-alveolar collagen application after surgical extraction of impacted lower third molars reduce the incidence of alveolar osteitis?


Eligibility criteria:
inclusion criteria: forty patients aged between 18- 40 years old, asa1, who have bilateral symmetrical impacted lower third molars and visit the oral surgery clinics of king saud medical city for extraction. exclusion criteria: uncontrolled systemic diseases, diabetes, bone diseases, smokers, epinephrine contraindications, pregnant women, breastfeeding women, and those who were using oral contraceptives. other exclusion criteria are the presence of acute infection and facial swelling, cystic lesions, and tmj problems. moreover, any surgical extraction that lasts more than 30 minutes +/- 5 minutes, or has been done without the whole standardized steps will be excluded.

Keywords: alveolar osteitis collagen sponge impacted lower third molar
the effect of a high-fat vs. high-sugar diet on liver fat accumulation and metabolism

Conditions: Fat; Liver; NAFLD

Summary: non-alcoholic fatty liver disease (nafld) is the most prevalent liver disease in the world. it is currently unclear why fat starts to accumulate in the liver, although both the amount and type of food consumed have been implicated. the majority of studies that have investigated the effects of dietary fat or sugar on liver fat have fed volunteers excess calories, which are known to increase liver fat. the effect of specific dietary components, when consumed as part of a diet not containing excess calories, on liver fat accumulation remains unclear.

this research aims to investigate the role excessive consumption of specific macronutrients may play in the development of nafld. this will be achieved by subjecting participants to two specific dietary interventions (high-fat, low-carbohydrate and low-fat, high-carbohydrate) in a randomized, crossover research design. liver fat content, and whole-body and hepatic fasting and postprandial lipid metabolism will be assessed before and after the specific dietary interventions.

Eligibility criteria:
inclusion criteria: * participant is willing and able to give informed consent for participation in the study. * bmi \>25 \<35kg/m2 * no medical condition or relevant drug therapy known to affect liver, lipid or glucose metabolism exclusion criteria: * age \ 65 years * body mass index \ 35kg/m2 * a blood haemoglobin \<120mg/dl * any metabolic condition or relevant drug therapy * people who do not tolerate fructose * smoking * history of alcoholism or a greater than recommended alcohol intake * pregnant or nursing mothers * women prescribed any contraceptive agent or device including oral contraceptives, hormone replacement therapy (hrt) or who have used these within the last 12 months * history of severe claustrophobia * presence of metallic implants, pacemaker * haemorrhagic disorders * anticoagulant treatment

Keywords: nafld fat intake sugar intake
endoscopic tri-modal imaging to distinguish functional dyspepsia from reflux disease

Conditions: Gastroesophageal Reflux Disease; Dyspepsia; Bile Reflux

Summary: endoscopic tri-modal imaging which combines narrow-band imaging(nbi), autofluorescence imaging (afi) and white-light imaging (wli) could be used to identify the indistinct changes in the gut caused by reflux disease,either acid reflux or bile reflux, which make it possible to differentiate reflux disease from functional dyspepsia (fd).

functional dyspepsia (fd) and acid/bile reflux disease are common. these diseases share similar clinical manifestations. individuals with functional dyspepsia (fd) often present upper abdominal pain or discomfort, bloating, early satiety, loss of appetite, and no organic factors underlie it. individuals suffering from acid/bile reflux disease often complain heartburn, upper abdominal burning or discomfort. what is more, there are always no specific changes on traditional endoscopy that can be used to differentiate these diseases (except erosive esophagitis). though proton-pump inhibitor (ppi) test is frequently applied to confirm the diagnosis of acid reflux disease, but certain amounts of individuals with gastroesophageal reflux disease (gerd) do not show favorable response to ppi test. in order to make a distinction of these diseases, esophageal ph-metry is needed, however it is not always available in most clinics. recent data showed that new endoscopic technology such as endoscopic tri-modal imaging could demonstrate indistinct lesions caused by gerd which are not detectable by standard endoscopy, subsequently improve endoscopic diagnosis of these diseases. in addition, simultaneous analysis of gastric juice can help to determine whether bile reflux is present or not. as it is known, pathologic refluxes underlie not functional dyspepsia but acid/bile reflux disease. hence, it is hypothesized that endoscopic tri-modal imaging in combination with simultaneous analysis of gastric juice could be used to differentiate functional dyspepsia from acid/bile reflux disease.

Eligibility criteria:
inclusion criteria: * symptoms suggestive of gerd or dyspepsia. * presence of symptom for longer than 6 month * provision of written informed consent exclusion criteria: * any known upper gi disease, other than reflux esophagitis * active or healing gastroduodenal ulcer (except scars) * history of esophageal or gastric surgery. * clinically significant heart, lung, liver or kidney disease * allergy to proton-pump inhibitor * pregnancy

Keywords: endoscopic tri-modal imaging gastric juice functional dyspepsia acid reflux disease bile reflux
factors associated with hypoventilation in the myotonic dystrophy, progressive profile over 5 years

Conditions: Myotonic Dystrophy, Steinert

Summary: the aim of this study is to determine the factors associated with alveolar hypoventilation in terms of cognitive impairment, daytime sleepiness, respiratory function, nocturnal respiratory events this evaluation will clarify the clinical phenotypes of respiratory disease in myotonic steinert dystrophy.


Eligibility criteria:
inclusion criteria: * myotonic dystrophy of steinert genetically confirmed (number of known ctg repeats), in its classical form of adult exclusion criteria: * inability to perform efr assessment or polysomnography * moderate to severe asthma according to the gina classification * moderate to severe copd (\> stage 1 of the gold recommendations) * other significant respiratory pathology * patient already on niv, cpap or under oxygen therapy * impossibility of receiving enlightened information * inability to participate in the entire study

Keywords: sleep apnea syndrome muscular diseases non invasive ventilation diaphragmatic disorder
effect of high-dose nac on patients with dpn

Conditions: Diabetic Neuropathies

Summary: the aim of the current study is to evaluate the efficacy and safety of high dose oral nac (2400 mg/day divided into two doses) as an adjunct therapy on oxidative stress, inflammatory markers and clinical outcome in patients with type 2 diabetes suffering from diabetic peripheral neuropathy.

patient written informed consent will be taken prior to study conductance * lab assessment will be done at baseline and at the end of the study by withdrawing 7 ml of whole blood for assessment of following parameters: hba1c, liver \& renal functions * inflammatory markers including: human nuclear factor erythroid 2-related factor (nrf2) \& tumor necrosis factor alpha (tnf-α) using elisa kit * oxidative stress markers: glutathione peroxidase using elisa kit inflammatory and oxidative stress marker samples will be stored at -80 for further evaluation using elisa kit at the end of the study

Eligibility criteria:
inclusion criteria: 1. males or females aged 18-50 years diagnosed with type 2 diabetes taking oral hypoglycemic with controlled at hba1c (6%-7%.) 2. patients diagnosed with diabetic neuropathy (by pinprick, temperature probe, ankle reflex, and vibration perception (128-hz tuning fork) or pressure sensation (10 g monofilament test). exclusion criteria: 1. patients with acute and chronic inflammatory conditions, consuming any antioxidant supplements or anti-inflammatory medicines. 2. pregnancy or lactation or expecting to get pregnant during the study. 3. medical, psychological, or pharmacological factors interfering with the collection or interpretation of study data. 4. cancer patients. 5. anyone having hypersensitivity to n-acetylcysteine. 6. anyone already taking n-acetylcysteine.
concordance of the quotient attention deficit hyperactivity disorder (adhd) system report with teacher and parent assessments for symptoms of adhd

Conditions: Attention Deficit Hyperactivity Disorder

Summary: to demonstrate concordance between the quotient adhd system report and standard dsm-iv based parent and teacher reported rating/assessment scales, currently the accepted method of symptom measurement for subjects diagnosed with attention-deficit/hyperactivity disorder (adhd).

public school based study for children ages 8 through 14 years of age. children previously identified and currently receiving an individualized education program (iep) or 504 accommodations in the classroom setting for symptoms of adhd. open enrollment of 30 subjects, both male and female. one study visit in which subjects will perform/receive the following assessments/evaluations: 1. quotient adhd system test 2. vanderbilt adhd diagnostic teacher rating scale 3. vanderbilt adhd diagnostic parent rating scale the primary analytical goal is to examine the extent of agreement of the quotient adhd system(either individual measures or in combination) with standard measures (vanderbilt adhd diagnostic teacher rating scale and vanderbilt adhd diagnostic parent rating scale) and to compare this agreement with that seen between the standard measures.

Eligibility criteria:
inclusion criteria: * a student attending one of three public elementary schools in the new hampshire school administrative unit #44. * age 8 through 14 years old at time of enrollment. * pre-identified as receiving an individualized education program (iep) or 504 accommodations for symptoms of adhd in the school setting by the special education coordinator in the school district. * a parent/guardian of the child must be willing to participate. exclusion criteria: * no subject will be excluded from participation based on race, ethnicity, or gender. anyone meeting inclusion criteria, who are willing to sign consent and participate, will be included in the study.

Keywords: inattention hyperactivity impulsivity
functional assessment and muscle evaluation through exercise trial

Conditions: Urinary Incontinence

Summary: the purpose of this study is to decrease rates of urinary incontinence in older women by building strength in the pelvic and lower body muscle through exercise and rehabilitation.

this study will provide data on benefits of combination the multimodal strengthening and aerobic conditioning rehabilitation program with pelvic floor muscle training and will help to characterize changes in pelvic floor and lower extremity muscles in older women with urinary incontinence. the study focuses on a patient-centered approach to improve overall physical function in older women. the study will evaluate the incremental benefit of endurance and lower extremity muscle strengthening in addition to benefits from pelvic floor muscle training. we anticipate that this approach will decrease rates of urinary incontinence because the proposed intervention will focus on prevention of functional decline through endurance, strength, and balance training among older women. the study will evaluate the pathophysiology of urinary incontinence in older women through evaluation of pelvic floor and lower extremities muscles with an innovative mri protocol.

Eligibility criteria:
inclusion criteria: 1. women ≥ 65 years older 2. symptomatic ui 3. symptoms ≥ 3 months 4. episodes of ui on 3-day bladder diary 5. stress, urgency, and mixed ui exclusion criteria: 1. women unable to have functional assessment and/or complete bladder diary 2. impaired mental status (mmse \<25) 3. post-void residual ≥ 150 ml 4. non-ambulatory (wheelchair bound), unable to complete mobility assessments 5. hematuria 6. urinary tract infection 7. continuous incontinence 8. pelvic organ prolapse \> stage 2 9. fecal impaction (no bm within 1 week), severe congestive heart failure (leg swelling edema 2+), uncontrolled diabetes (positive urine glucose dipstick test) 10. women with significant neurological or musculoskeletal conditions that compromise mobility (stroke, multiple sclerosis, amyotrophic atrophic lateral sclerosis, severe rheumatoid arthritis) 11. women with contraindications to undergo mri including claustrophobia.

Keywords: urinary incontinence pelvic floor disorder pelvic floor muscle strength disability aging atrophy exercise magnetic resonance imaging fatty infiltration physical therapy multi-modal rehabilitation stress urinary incontinence urge urinary incontinence mixed urinary incontinence
cognitive remediation therapy for brain tumor patients: improving working memory

Conditions: Glioma; Brain Tumor, Primary

Summary: to investigate a computer-based cognitive remediation therapy (crt) for brain tumor patients at the massey cancer center on measures of cognitive functioning (e.g., working memory, attention, processing speed, language, visuospatial functioning, immediate and delayed memory, or executive functioning) over time.

participants will be recruited by their neuropsychologist in the vcu massey cancer center following standard neuropsychological evaluation (their neuro-oncologist may refer them to this study). if meeting inclusion criteria (described in later sections on participants), participants will be recruited and enrolled in the study. two groups will be formed: high grade gliomas (who grade iii or iv; n=15) and low grade gliomas (who grade ii; n=15). participants will be followed over 11 months. the two groups will follow identical study timelines.

Eligibility criteria:
inclusion criteria: * confirmed primary brain tumor diagnosis via mri and their neuro-oncologist * a minimum of 2 months post-surgical resection or biopsy(if applicable) * and/or a minimum 1 month post radiation treatment (if applicable) * karnofsky performance status more than 60 * estimated intelligence at least 80 (standard score) * demonstrated attention difficulties (t-score of at least 65 on attention questionnaire or 1 or more standard deviations below mean on direct attention measures) * no history of cognitive disorder * no history of mood disorder * predicted life expectancy of at least 12 months * computer capability at home or provided a departmental ipad mini to borrow for study purposes * primarily english speaking * aged 18+ (for which there is available age-adjusted neuropsychological testing standardization / normative data) exclusion criteria: * if they are not patients of massey cancer center or do not meet the inclusion criteria listed above

Keywords: high grade gliomas (who grade iii or iv) low grade gliomas (who grade ii)