Kornimate/medical-research-clean huggingface dataset:
theophylline, n-acetylcysteine, and theophylline plus n-acetylcysteine in preventing contrast-induced nephropathy

Conditions: Contrast-Induced Nephropathy

Summary: the aim of this study is to determine the efficacy of theophylline, n-acetylcysteine and, and theophylline plus n-acetylcysteine in the prevention of contrast-induced nephropathy. investigators assume that theophylline plus n-acetylcysteine is more effective than theophylline alone and n-acetylcysteine alone. investigators include patients referring for elective coronary angiography or angioplasty and allocate them to each of the mentioned treatments from 24 hours before to 48 hours after administration of contrast material. investigators then measure serum creatinine and see if it is raised by ≥ 0.5 mg/dl or ≥ 25% of the baseline value.


Eligibility criteria:
inclusion criteria: * adult patients * candidate of elective coronary angiography or angioplasty * at least moderate risk for contrast induced nephropathy exclusion criteria: * unstable angina or myocardial infarction, cardiac arrhythmia, seizures, acute renal failure, end-stage renal disease * unstable serum creatinine * unstable hemodynamic * intravascular administration of contrast material in the past month * using theophylline or n-acetylcysteine in the past month, * known hypersensitivity to theophylline or n-acetylcysteine

Keywords: coronary angiography side effects contrast-induced nephropathy prevention
omega-3 acids and cardio - vascular complications in patients with chronic kidney disease in stage 1-3

Conditions: Chronic Kidney Disease; Cardiovascular Complications

Summary: the national register of nephrology in 2007 shows, similarly to the european data, a problem of a high mortality rate among polish dialysis patients. the main reason of death among chronically dialysis patients are cardio - vascular system diseases. according to "the report on the condition of renal replacement therapy in poland in 2007", these diseases are the cause of 53% deaths in poland. the patients with chronic kidney disease (pchn) are particularly at risk of cardio - vascular complications. these complications occur on average 30 times more often than in the whole population, and among young dialysis people, these complications occur 300 times more often. in the development of cardio - vascular complications polyunsaturated omega-3 acids (especially eicosapentaenoic acid - epa and docosahexaenoic acid - dha) take a special position. the reaction of polyunsaturated omega-3 acids on the cardiovascular system results from the enrichment of phospholipids of cell membranes within epa and dha. it should be noted that their impact is dependent on the type of acid and on the dose. docosahexaenoic acid reacts with lipids and lipoproteins, blood pressure, heart rate, amount of glucose, and eicosapentaenoic acid is responsible for antiplatelet effect. this project is aiming at defining and elaborating on the connection between omega-3 acids, and cardiovascular complications, their influence on the functioning of the cardiovascular system, and moreover, a better understanding of the effects of therapeutic and pharmacological therapies in patients at different stages of chronic kidney disease. carrying out this project will be a good start to shape an international project in this area.

the survey will cover 90 patients from chronic kidney disease at different stages of the disease(i-iii) and 30 healthy subjects as a comparison group. at the beginning and at the end of the observation period, besides the clinical test, some other tests will be carried out: echocardiography, pulse wave velocity (pwv), ambulatory blood pressure monitoring (abpm). blood will be collected for laboratory tests such as: lipid profile, uric acid, c reactive protein (crp), blood urea nitrogen (bun), creatinine, morphology, calcium (ca),phosphorus (p), ca x p, ionogram, xanthine oxidase, monocyte chemoattractant protein (mpc1),omega-3 acids, resolvin and protectins - the metabolites of omega-3 acids, creatinine excretion, mpc1 excretion and excretion of uric acid. the patients will be treated with omega-3 acids as a gold omega 3 preparation (2x1 capsule where 1 capsule = 1000 mg) for 6 months.

Eligibility criteria:
inclusion criteria: - chronic kidney disease (ckd) stage 1-3 exclusion criteria: * without diabetes * without immunosuppressive therapy

Keywords: chronic kidney disease cardiovascular complications
clinical trial to compare the efficacy of a fluoride gel and a dental bonding agent in treatment of tooth sensitivity

Conditions: Dentin Sensitivity

Summary: this study compares the efficacy of two dental interventions in the treatment of cervical dentine sensitivity. the participants will be selected from adult dental patients registered at a general dental practice in west sussex, uk. the participants will be split into 2 groups. one group will receive the intervention of topical fluoride varnish application while the other group will receive a topical application of self-etching dentine bonding agent.

topical fluoride varnish(tfv) and self-etching dentine bonding agent (sedba) are both routinely used in dentistry in the management of cervical dentine sensitivity(cds). both interventions are topically applied and well tolerated by patients. the interventions differ in mechanism of action. tfv releases fluoride which is incorporated into the organic matrix of dentine making the dentine tubules less conductive. dentinal tubules form the key conduit between stimulus and pain perception in the tooth. sedba differs in that it penetrates and occludes the tubules. it is light cured for an almost instant set time.

Eligibility criteria:
inclusion criteria: * aged 18-60. * exhibiting cds elicited by the two test stimuli in relation at least one tooth. exclusion criteria: * patients who have undergone comprehensive periodontal treatment in the past 3 months. * patients under the age of 18 or unable to provide valid consent. * teeth that have visible fracture lines, caries, crowns or have been endodontically treated. * patients taking analgesic medication for any systemic conditions.
mesenchymal stem cells treat liver cirrhosis

Conditions: Liver Cirrhosis

Summary: the purpose of this study is to investigate the efficacy of umbilical cord mesenchymal stem cells (mscs) transfusion in the treatment of liver cirrhosis. liver function will be monitored by serum analysis. the levels of serum alanine aminotransferase (alt), total bilirubin (tb), prothrombin time (pt), prealbumin(pa) and albumin (alb) will be examined at pre-transfusion, and 3 days to 2 years post-transfusion. child-pugh scores, model for end-stage liver disease scores and clinical symptoms will be assessed simultaneously.

patients with liver cirrhosis will be randomly divided into three groups. umbilical cord mscs will be infused to patients using interventional method via hepatic artery for one group. the catheter will be inserted to proper hepatic artery. after the catheter placement confirmed by angiography, umbilical cord mscs will be infused slowly in 20-30 minutes. umbilical cord mscs will be infused intravenously slowly in 30-60 minutes in the intravenous infusion group. the control group will receive conserved therapy. the levels of serum alanine aminotransferase (alt), total bilirubin (tb), prothrombin time (pt), prealbumin(pa)and albumin (alb) will be examined at re-transplantation, and 3 days to 2 years post-transplantation. the efficacy of umbilical cord mscs transfusion will be investigated. the efficacy of different interventional therapies will also be compared.

Eligibility criteria:
inclusion criteria: * age 18-70 years. * imaging evidences of liver cirrhosis. * child-plough score of 8 or more. * model for end-stage liver disease score of 20 or more. exclusion criteria: * liver tumor on ultrasonography, ct or mri examination. * problems in organs other than liver (e.g. heart or lungs). * history of moderate to severe hepatic encephalopathy or variceal bleeding. * imaging evidences of vascular thromboses. * coma.

Keywords: liver cirrhosis mesenchymal stem cells hepatic artery infusion intravenous infusion
comparing the effect of under the tongue olanzapine versus swallowed olanzapine on body mass index (a ratio of weight to height)

Conditions: Schizophrenia; Schizoaffective Disorder; Bipolar Disorder

Summary: this study is testing if under the tongue olanzapine for schizophrenia, related psychosis, schizoaffective disorder or bipolar disorder will have less weight gain than olanzapine that is swallowed, in patients who are already gaining weight on olanzapine.


Eligibility criteria:
inclusion criteria (patients must): * be at least 18 years old * have gained weight while taking olanzapine * be able to visit the doctor's office seven times over 4 months (17 weeks) exclusion criteria (patients must not): * have started a weight loss program within the last 8 weeks * have an illness that might affect patient's weight during the study * have an allergy to phenylalanine, mannitol or saccharine * be taking any medication (except for olanzapine) that might affect patient's weight
sinew acupuncture for neck pain: randomized controlled trial

Conditions: Neck Pain

Summary: the study aims to examine the efficacy and safety of sinew acupuncture for chronic mechanical neck pain (cmnp).

objectives: sinew acupuncture is a superficial needling technique with the advantage of minimal pain, feasible manipulation, and no apparent adverse effects. the proposal aims to examine the efficacy and safety of sinew acupuncture for chronic mechanical neck pain (cmnp). hypothesis to be tested: sinew acupuncture can reduce pain intensity, and improve neck pain disability and health-related quality of life without significant side effects for cmnp subjects compared to a sham acupuncture treatment. design: a randomized, subject- and assessor-blind, sham acupuncture-controlled clinical trial participants: subjects (n=130) will be randomized into sinew acupuncture or sham acupuncture group (in 1:1 ratio). study instrument: visual analog scale (vas), northwick park neck pain questionnaire (npq) and short form-36 (sf-36) intervention: sinew acupuncture group will receive five sessions of needling in two weeks. sham group will receive the non-invasive treatment with the same procedures. all subjects are followed up for 4 weeks. main outcome measures: vas for neck pain intensity at week 3 serves as the primary outcome. vas at other time points, npq score and sf-36 at week 1, 2, 3, and 6, and adverse events are analyzed as the secondary outcomes. data analysis: analysis will be on the 'intention to treat' principle. t-test and mixed-effect model analysis will be used to measure primary and secondary outcomes respectively. expected results: five sessions of sinew acupuncture treatment can significantly reduce neck pain intensity, and improve neck pain disability and quality of life without obvious side effects.

Eligibility criteria:
inclusion criteria: * (1) aged 18 years or above; (2) able to read and write chinese; (3) the pain is located between the neck and shoulder regions and movement or palpation of the cervical region provokes the symptoms (18); (4) the pain has persisted for more than 3 months; (5) vas (0 to 100 mm) pain score is ≥30 mm at baseline assessment; (6) no treatments (chinese medicine, acupuncture, moxibustion, physiotherapies, medications, etc) intended for pain management have been received within the preceding two weeks. exclusion criteria: * (1) a history of fracture or surgery to the neck; (2) malignant tumor; (3) cervical congenital abnormality; (4) a severe psychiatric illness; (5) needle phobia; (6) acupuncture treatment in the preceding 3 months, and (7) other acupuncture contraindications as indicated in hospital authority guideline on safety in acupuncture for chinese medicine practitioners (quality and risk sub-committee, hospital authority, 2010).

Keywords: sinew acupuncture neck pain chronic pain
impact of daa uptake in controlling hcv epidemic and modeling interventions for hcv elimination among hiv-infected persons in san diego

Conditions: Hepatitis C; Hepatitis C, Chronic; HIV/AIDS

Summary: a retrospective and prospective study among people living with hiv (plwh) that assesses hepatitis c (hcv) treatment uptake during periods before and after direct acting antivirals (daa) introduction, and its impact on the hcv epidemic among plwh.

a study that aims to quantify the state of daa uptake and its impact on the hcv epidemic among plwh in san diego, and to characterize negative predictors of daa treatment uptake among plwh in san diego. retrospective and prospective data from ucsd owen clinic will be utilized to calculate hcv prevalence, primary incidence, and reinfection incidence. using mathematical epidemic models, the study will assess levels of existing and scaled-up interventions necessary for hcv elimination from plwh in san diego.

Eligibility criteria:
inclusion criteria: * any adult (≥ 18 years) hiv-infected patient attending the ucsd owen clinic * with history of acute or chronic hcv infection defined as having a detectable hcv viral load with or without a positive hcv antibody exclusion criteria: * with no history of or current hcv infection defined as having a negative hcv antibody from 2008 to 2020

Keywords: hiv hepatitis c direct acting antivirals hepatitis c modeling
comparison of hyperemic efficacy between nicorandil and adenosine for fractional flow reserve (ffr) measurement

Conditions: Coronary Artery Disease; Myocardial Ischemia

Summary: the purpose of this study is to evaluate the efficacy of nicorandil in the achievement of maximal coronary hyperemia compared with adenosine.


Eligibility criteria:
inclusion criteria: * non -infarct related, patients with moderate coronary artery stenosis * normal left ventricular ejection fraction on echocardiogram exclusion criteria: * infarct-related arteries or clinically unstable state * collateral blood flow to the target vessel is shown * atrioventricular block on electrocardiogram * reduced left ventricular ejection fraction (\<50%) or left ventricular hypertrophy on echocardiogram * contraindication of adenosine * bronchial asthma

Keywords: adenosine nicorandil fractional flow reserve maximal hyperemia
this is an early study to investigate the effect of gimatecan® in adults with solid tumor

Conditions: Solid Malignancies

Summary: gimatecan® is sigma-tau research's new, potent, oral topoisomerase i inhibitor. drugs in this class play a crucial role in destroying dna replication in tumors. we are conducting this study to determine the maximum tolerated dose of our compound, when given as a capsule, rather than by intravenous injection.


Eligibility criteria:
inclusion criteria: * histologically/cytologically proven advanced solid tumors * life expectancy of at least 3 months with normal hematological, liver and renal function exclusion criteria: * pregnant and lactating patients * participation in any investigating drug study within 4 weeks preceding treatment start or concurrent treatment with any other anti-cancer therapy * gastrointestinal dysfunction that could alter absorption or motility

Keywords: solid tumor camptothecin pharmacokinetics
perspections of stroke patients and physiotherapists in robotic rehabilitation

Conditions: Stroke; Paralysis; Physician's Role

Summary: this study was a cross-sectional study. the insights of stroke patients and physiotherapists were assessed with the quantitative questionnaires. the results were provided as number, percentage, mean, and standard deviation. the results of the insights of the current sapmle were given and compared the previous studies. the authors though that the results of the study can fill the gaps in robotic rehabilitation and support a better robotic rehabilitation experience.

fifty stroke patients and fifty seven physiotherapists included the study. a seventeen-item and eight-item questionnaire s were created for stroke patients and physiotherapists, respectively. the descriptive data of the stroke patients and physiotherapists were presented. the results were compared with the literature and interpreted to guide future studies.

Eligibility criteria:
for stroke patients inclusion criteria: * having a single stroke exclusion criteria: * having a communication problem * having another neurological condition which can affect the study for physiotherapists inclusion criteria: * graduating from a physiotherapy and rehabilitation program with at least a bachelor degree * working in denizli exclusion criteria: -
patch study (patch-augmented rotator cuff repair)

Conditions: Rotator Cuff Tears

Summary: this single-center, prospective, randomized controlled study will compare patients allocated to two treatment arms who are undergoing surgery to repair rotator cuff tears: (1) arthroscopic rotator cuff reconstruction using fixation with anchors augmented with a synthetic polyester patch, and (2) arthroscopic rotator cuff reconstruction using fixation with anchors and no augmentation with a synthetic polyester patch. the primary objective is to compare complications (primarily retear rates) and the secondary objective is to compare mid- and long-term clinical and radiological outcomes using standard orthopedic assessments, such as the subjective shoulder value and the constant-murley score.

this single-center, prospective, randomized controlled study will compare patients allocated to two treatment arms who are undergoing surgery to repair rotator cuff tears: (1) arthroscopic rotator cuff reconstruction using fixation with anchors augmented with a synthetic polyester patch, and (2) arthroscopic rotator cuff reconstruction using fixation with anchors and no augmentation with a synthetic polyester patch. the primary objective is to compare complications (primarily retear rates) and the secondary objective is to compare mid- and long-term clinical and radiological outcomes using standard orthopedic assessments, such as the subjective shoulder value and the constant-murley score. the pitch-patch is a single-use synthetic polyester patch (pitch-patch, neoligamentstm, leeds, uk) intended to reinforce the rotator cuff following or during repair by sutures or suture anchors where weakness exists in the soft tissue. the surgical group will be randomly assigned, and each group will include 150 patients. after surgery, patients will be followed for two years and undergo clinical and radiological assessments. the main research question to be answered by this investigation is whether synthetic patch augmentation can significantly improve outcomes in patients with rotator cuff tears from either degenerative or traumatic origins versus patients with no patch augmentation.

Eligibility criteria:
inclusion criteria: * adults with massive rotator cuff tear * tear must affect at least two tendons * primary surgery only * origin of tear can be either degenerative or traumatic * german language speaking exclusion criteria: * fatty infiltration grade 4 (according to goutallier) * bilateral tears * cases of arthritis or severe osteoarthritis * structural or pathological condition of the bone or soft tissue that could impair healing * unable or unwilling to restrict activities to prescribed levels or follow rehabilitation guidelines * unable or unwilling to give consent (language barrier or cognitive impairment) * unwilling or unable to be assessed at 1- and 2-year follow-up assessment visits

Keywords: rotator cuff repair
restoration of permanent molars affected with (mih) using composite restorations or preformed metal crowns

Conditions: Molar Incisor Hypomineralization

Summary: the aim of this study is to compare clinical outcome of using direct esthetic composite restorations in managing mih cases and the use of preformed metal crowns.

molar incisor hypomineralization can represent a serious and challenging clinical management problem. children with mih require higher levels of treatment needs and demonstrate considerable management problems. for most severely affected mih molars, direct esthetic restorative materials or preformed metal crowns will be the treatments to choose between. a number of aspects which could support decision-making, however, are not clearly demarcated. first and foremost, it is not clear if both treatments are similarly acceptable for patients and providers.

Eligibility criteria:
inclusion criteria: 1. children with mih in one fully erupted molar or more. 2. age ranging from 7-12 years. 3. cooperative children 4. good general health. exclusion criteria: 1. patients participating in other experiments. 2. patients with parents planning to move away within the following year. 3. patients with only mildly affected mih molars that do not require extensive restorative treatment. 4. mih-affected molars that have a very poor prognosis and require extraction. 5. first permanent molars that are affected with other developmental defects, such as hypoplasia, dental fluorosis or amelogenesis imperfecta.

Keywords: mih
an epidemiology study of treatment resistant depression in the united states (us)

Conditions: Depressive Disorder, Treatment-Resistant

Summary: the purpose of this study is to describe the epidemiology of treatment resistant depression (trd) in the us, including the population incidence of trd, and trd as a proportion of pharmacologically treated depression (ptd), and stratify the estimates by sex and age group, with separate estimates for the medicaid population, the medicare population, and the privately insured population. anonymized participants data will be used for the analysis.


Eligibility criteria:
inclusion criteria: * have been in the database for the past year (ignoring breaks of \< 30 days) * have not had, an excluded diagnosis or dispensing of an ad medication during the past year * are aged 14 to 60 years (if in the ccae or mcdc databases), or are aged greater than or equal to (\>=) 65 years (if in the mcdr database). age is defined as age on jan 1, 2011. the boundary at age 60 for the first two databases is intended to avoid loss to follow-up due to transfer to medicare at age 65. the boundary at age 65 for the mcdr database reflects the fact that very few people described by that database are aged less than 65 exclusion criteria: - participants will be excluded when they receive diagnoses schizophrenia, bipolar disorder including mania or dementia