Kornimate/medical-research-clean huggingface dataset:
tai chi for knee oa pain management: a mechanistic study

Conditions: Knee Osteoarthritis; Mind-body Exercise

Summary: this study is to determine how 8-week tai chi intervention alters plasma endocannabinoid and its receptors in monocytes/marcrophages, plasma oxylipinds, plasma brain-derived neurotrophic factor, brain white matter connectivity/efficiency, and functional/clinical outcomes in women with knee oa.

knee osteoarthritis (oa) is one of the five leading causes of disability. previous studies have shown that a mind-body moderate-intensity tai chi (tc) exercise (8-24 weeks) reduced pain and improved physical function for knee oa, when compared to a waiting list, attention control, usual physical activity, or physical therapy. however, tc's mechanisms of action regarding improvement of one's clinical condition and its functional outcomes in individuals with knee oa are poorly understood. this study is to determine how 8-week tc intervention alters plasma endocannabinoid and its receptors in monocytes/marcrophages, plasma oxylipinds, plasma brain-derived neurotrophic factor, brain white matter connectivity/efficiency, and functional/clinical outcomes in women with knee oa.

Eligibility criteria:
inclusion criteria: 1. postmenopausal women. 2. womac pain score ≥ 50 on at least 1 of the 5 questions in pain subscale (range of 0 to 100, with higher scores indicating greater pain. 3. english literacy. 4. able to undergo an mri scan 5. diagnosed have the following symptoms associated with knee oa based on american college of rheumatology clinical classification criteria for osteoarthritis (peat 2006). pain in the knee. need to at least 3 of the following: over 50 years of age, less than 30 minutes of morning stiffness, crepitus on active motion, bony tenderness, bony enlargement, or no palpable warmth of synovium. exclusion criteria: 1. prior experience with mind-body practice (e.g. tc, qi gong, yoga, or acupuncture) or physical therapy programs for knee oa within the past 3 months. 2. severe medical limitations (i.e., dementia, symptomatic heart or vascular disease, or recent stroke) precluding full participation. 3. medical/neurologic or other systemic diseases affecting the musculoskeletal systems (i.e. polio/parkinson's/multiple sclerosis, etc. in addition to cerebral vascular accident or stroke) and diabetes with peripheral neuropathy affecting their sensory/balance. 4. intra-articular steroid injection or reconstructive surgery on most severely affected knee in the past three months. 5. intra-articular hyaluronic acid injections on most severely affected knee in the past six months. 6. inability to walk without an assistive device.
prospective ed headache cohort study

Conditions: Headache

Summary: the purpose of this study is to determine how often headaches recur and to learn how to predict continued suffering from headache after emergency department discharge.

the majority of the 5 million people who arrive at emergency departments (ed) with a headache every year are suffering from an acute exacerbation of a chronic, recurrent headache disorder. the role of the ed in treating these patients has been ill-defined. often emergency physicians will treat the acute exacerbation and will not attend to the natural history of the disease. however, about two thirds of primary headache patients will suffer a recurrent headache in the 24 hours after discharge from the ed. and, many patients will continue to suffer recurrent headaches for months after their ed discharge. the purpose of this study is to learn how often headaches recur and to try to find a way to predict who will have a recurrent headache after ed discharge. after standard ed treatment for headache, participants in the study will be asked to answer questions about prior headaches and medical history, and some census-like questions about race/ethnicity, salary, and education via a 20-minute interview with a research associate. the researchers will follow-up with 10-minute telephone calls to each participant's home in 24 hours and in 3 months with additional questions. total length of time for study participation is approximately 40 minutes.

Eligibility criteria:
inclusion criteria: * emergency department patients who present primarily for headache. * need to consent to and be available for follow-up

Keywords: headache emergency department migraine recurrent headache
lcr35 / icu / p. aeruginosa

Conditions: Pseudomonas Infections

Summary: preventing carriage of potentially pathogenic micro-organisms from the aerodigestive tract is an infection control strategy used to reduce the occurrence of nosocomial infections - including ventilator-assisted pneumonia - in intensive care units. the use of antibiotics is controversial and can lead to adverse effect such as the selection of highly resistant pathogens. the purpose of this study was to investigate the effect of oral administration of a probiotic strain, lactobacillus, on gastric and respiratory tract colonisation/infection by pseudomonas aeruginosa strains, according to the concept that an indigenous flora has a protective effect against secondary colonisation.

in this prospective double-blind randomised study, icu patients receive twice a day either an oral dose of lactobacillus casei rhamnosus, the available pharmaceutical form, or a placebo. digestive tract carriage of pseudomonas aeruginosa is monitored by cultures of gastric aspirates. the occurrence of respiratory tract colonisations / infections is monitored throughout the study. evaluation criteria are the delay and the rates of gastric p. aeruginosa colonisation and respiratory tract infection or colonisation. chi-square or two tailed fisher exact test are used for comparing qualitative variables and student's t-test or mann-whitney test for quantitatives variables. the mean of non-acquisition expectancy (nae), length of stay without p. aeruginosa acquisition, was calculated and p. aeruginosa non-colonized patient rates were estimated and the two groups compared with regard to survival curves from grouped data using the kaplan meier method and the logrank test. variables with a p. value ≤0.15 in the univariate analysis were included in a logistic regression and a cox regression model for multivariate analysis.

Eligibility criteria:
inclusion criteria: * more than 18 years old * length of stay longer than 48h * with a nasogastric feeding tube exclusion criteria: * - less than 18 years old * length of stay \< 48h * immunosuppression * absolute neutrophile count \< 500/mm3 * gastro-intestinal bleeding * contraindicated enteral feeding * positive p. aeruginosa gastric aspirates or respiratory tract specimens during the first four days after hospital admission

Keywords: probiotic pseudomonas aeruginosa gastric colonization respiratory tract colonization ventilator aquired pneumoniae determine the effect of oral administration of this probiotic on gastric and respiratory tract colonisation/infection by p. aeruginosa
hypobaric spinal or hyperbaric in partial hip arthroplasty

Conditions: Post Operative Pain

Summary: the aim of this study was to compare the effects of hypobaric and hyperbaric spinal applications on patient haemodynamics, duration of anaesthetic effect and postoperative analgesia. thus, it was aimed to determine the method that protects haemodynamics more and suppresses postoperative pain complaints of patients better in this patient group with advanced age, comorbid systemic diseases and high risk of operation.

patients who are planned to be operated for partial hip replacement at adıyaman university training and research hospital, who are informed about the study and who agree to participate in the study with their written consent will be included in the study. patients who agree to participate in the study will be divided into two groups: hypobaric and hyperbaric spinal anaesthesia patients will be divided into two groups to be decided by the anaesthesiology and reanimation specialist responsible for the operation (hyperbaric/hypobaric). before the start of the operation, perfusion index (pi) values will be monitored with a probe in both lower extremities with standard asa monitoring. haemodynamic values (blood pressure arterial, peak heart rate, peripheral oxygen saturation), pi values of both extremities, duration of motor and sensory block, postoperative numeric pain scores of all patients will be recorded and these values will be compared in both groups. thus, it was aimed to compare the efficacy, safety, block times and contribution to pain management of each application.

Eligibility criteria:
inclusion criteria: * asa i-ii exclusion criteria: * asa iii-iv * deny to participiate * conditions that spinal anesthesia contraindicated
comparison of exercise with & without bracing in office workers with kyphosis

Conditions: Kyphosis

Summary: the study aims to compare pt and bracing in improving posture, pain, and functionality in patient with kyphosis. it also assess the additive benefits of combining pt with bracing. it also identify sustainable, non-surgical approaches for managing kyphosis in office

the study focuses on understanding kyphosis, defined as excessive forward curvature of the thoracic spine, has become increasingly prevalent in modern work environments due to the sedentary nature of desk jobs. kyphosis, characterized by a rounded upper back or "hunchback" appearance, is a clinical and postural problem with significant physical, functional, and psychosocial implications. among office workers, the condition is primarily postural, driven by long hours of desk work, inappropriate ergonomic settings, and inadequate postural awareness. the increasing prevalence of kyphosis in this demographic has led to a pressing need for effective nonsurgical management strategies, including physical therapy (pt) and spinal bracing.

Eligibility criteria:
inclusion criteria: * office workers diagnosed with postural kyphosis * age limit 30 to 45years * experience of upper back or neck pain lasting at least three months * spend a minimum of 6 hours per day in a seated position for work. exclusion criteria: * history of spinal surgery, severe scoliosis, or other significant spinal deformities. current engagement in any structured physical therapy program or use of bracing for posture. any neurological or musculoskeletal disorders impacting posture or movement.

Keywords: kyphosis
phase 2 dose-ranging efficacy and safety trial of sch 900271 in participants with primary hypercholesterolemia or mixed hyperlipidemia (p05675)

Conditions: Primary Hypercholesterolemia; Mixed Hyperlipidemia

Summary: the purpose of this study is to evaluate the effect of sch 900271 compared to placebo on the reduction of low-density lipoprotein cholesterol (ldl-c) from baseline to 8 weeks of treatment in participants with primary hypercholesterolemia (familial and nonfamilial) or mixed hyperlipidemia. the study will also evaluate the effect of sch 900271 on non-high density lipoprotein cholesterol (non-hdl-c) and various other lipids and lipoproteins. the safety of sch 900271 in this participant population will also be evaluated.


Eligibility criteria:
inclusion criteria: * adults of either sex 18 to 75 years of age, inclusive, with a diagnosis of primary hypercholesterolemia (familial and nonfamilial) or mixed hyperlipidemia (increased ldl-c and triglycerides \[tg\]) * must be free of any clinically significant disease, other than primary hypercholesterolemia or mixed hyperlipidemia that would knowingly interfere with study evaluations * must be willing to adhere to dietary recommendations, protocol requirements, and provide written informed consent exclusion criteria: the participant will be excluded from entry if any of the criteria listed below are met: * use of any investigational drug within 30 days of study entry * female of childbearing potential or lactating * postmenopausal (or perimenopausal) woman who is currently experiencing hot flashes (e.g. within 30 days of study entry * homozygous familial hypercholesterolemia * congestive heart failure new york heart association (nyha) class iii or iv * uncontrolled hypertension on or off therapy * cardiac arrhythmia requiring medication * clinical atherosclerotic disease that confers high risk for coronary heart disease (chd) events (e.g. clinical chd, symptomatic carotid artery disease, peripheral arterial disease, abdominal aortic aneurysm) * type 1 diabetes mellitus * type 2 diabetes mellitus * history of mental instability, drug/alcohol abuse or who has been treated or is being treated for severe psychiatric illness, which in the opinion of the investigator, may interfere with optimal participation in the study * gastrointestinal ulcer within 3 months of study entry * history of coagulopathy * history of gout * known active or chronic hepatic or biliary disease. * known significant impairment of renal function, dysproteinemia, nephrotic syndrome, or other renal disease * body mass index \>40 kg/m\^2 * taking non-steroidal anti-inflammatory drugs (nsaids) (acetaminophen and cyclooxygenase-2 \[cox-2\] inhibitors are allowed) * taking more than 100 mg aspirin per day * being treated with corticosteroids (oral, intramuscular, or intravascular) * more than 3 alcoholic beverages per day or its equivalent (one drink equals 1.5 ounces of 80 proof liquor or equivalent) during study participation
nursing-home residents given bread fortified with vitamin d3

Conditions: Vitamin D Deficiency; Low Bone Density

Summary: background. for older adults, serum 25-hydroxyvitamin d (25(oh)d) higher than 75 nmol/l lowers fracture risk and attainment of this 25(oh)d target may require 125 mcg (5000 iu)/d of vitamin d3. objective: we wanted to characterize the safety and efficacy of fortifying bread with a biologically meaningful amount of vitamin d3.

methods: in a single-arm design, 45 nursing-home residents consumed one bun/d that had been fortified with 125 mcg (5,000 iu) of vitamin d3 and 320 mg elemental calcium.

Eligibility criteria:
inclusion criteria: * healthy seniors in an institution in romania exclusion criteria: * known hypercalcemic or hypercalciuric disease

Keywords: dietary fortification vitamin d3 osteomalacia bread bone mineral density geriatrics cholecalciferol calcidiol osteoporosis dual-energy photon absorptiometry bread fortification
survival and quality of life after liver transplantation in patients aged 65 and over

Conditions: Patients Suitable for a Liver Transplant

Summary: the main objective of this non-interventional, single-center study is to assess survival and associated factors at 1 year in patients aged 65 and over who received liver transplantation

the expected benefits of this study are to identify the preoperative risk factors of mortality from liver transplant failure in patients aged 65 and over (90-day mortality and 1 and 3-year survival) will allow better selection. candidates for this age group. in the current context of organ shortage, this study should make it possible to reduce the number of risky transplants and thus improve the allocation of grafts.inclusion of patients who meet the inclusion criteria will be carried out during their hospitalization in the surgical department of the hepato-bilary center. included patients will receive a standardized geriatric assessment in addition to the usual assessment for a liver transplant. the geriatric assessment will be carried out and conducted as follows: geriatric scores and quality of life questionnaires. two geriatricians will perform the physical examination and blindly estimate each other's probability of survival at 90 days using a likert scale. geriatricians will be blinded to hepatic data (reasons for transplantation). the consultation as well as the completion of the questionnaire will be carried out during the pre-transplantation assessment. survival and quality of life will be assessed at 3 and 12 months post-transplantaion.

Eligibility criteria:
inclusion criteria: * candidates for liver transplantation * having expressed non-oppostion to his participation in study and documented in his medical file * with social coverage exclusion criteria: * emergency transplant patients * patient already included in another study * patient under guardianship or curatorship * expressing his opposition to participate in the study

Keywords: liver transplant
mayo clinic foregut surgery report card questionnaire

Conditions: Gastroesophageal Reflux; Fundoplication; Hernia, Hiatal; Surveys and Questionnaires

Summary: the mayo clinic foregut surgery report card questionnaire has been created in order to have a consistent evaluation tool for patients undergoing foregut surgery in order to standardize and validate outcome measures.

foregut surgery includes conditions of the esophagus, stomach and proximal small intestine. more specifically foregut surgery includes surgery for gastroesophageal reflux disease, hiatal hernias, and paraesophageal hernias. patients undergoing foregut surgery report having varying degrees of symptoms of reflux, regurgitation, dysphagia, and pain following surgery. providers also note varying degrees of outcomes. some of these issues can be assessed using ph probe testing, upper gi endoscopy, high resolution manometry, ct scans, and other testing. there are various validated questionnaires that have been used to assess problem areas of reflux, dysphagia, and pain such as the promis global health score, mayo ger score, modified dysphagia questionnaire-30 day, zubrod score, and pain scale. each of these symptoms, tests, and questionnaires contributes to the provider's understanding of the patient's outcomes but there is currently no assessment tool that brings all of the test findings and information reported by the patient as symptoms or answers to the questionnaires in a format that that is usable for the clinician and understandable for the patient who has specifically undergone foregut surgery. the mayo clinic foregut surgery report card questionnaire has been created in order to have a consistent evaluation tool for patients undergoing surgery in the foregut in order to standardize and validate outcome measures. data will be used to establish the validation of the mayo clinic foregut surgery report card questionnaire. data will also lead to the establishment of "normal" or expected scores for patients undergoing each type of foregut procedure.

Eligibility criteria:
* ≥ 18 years old * scheduled to undergo foregut surgery at mayo clinic rochester which includes surgery for gastroesophageal reflux disease, hiatal hernias, and paraesophageal hernias.

Keywords: esophageal reflux gastric acid reflux gastric acid reflux disease gastro-esophageal reflux gastro-oesophageal reflux gastroesophageal reflux disease reflux, gastroesophageal esophageal hernia hernia, esophageal hernia, paraesophageal hiatal hernia sliding hiatal hernia sliding esophageal hernia hernia, hiatus paraesophageal hiatal hernia questionnaires
postoperative urinary retention after reversal of neuromuscular block by neostigmine versus sugammadex

Conditions: Urinary Retention Postoperative; Laparoscopic Cholecystectomy; Neuromuscular Blockade; Sugammadex; Neostigmine; Neuromuscular Blocking Agents; Physiological Effects of Drugs

Summary: this study is intended to be a single-site, prospective, randomized, controlled study that intends to enroll a total of 230 patients undergoing laparoscopic cholecystectomy at parkland hospital. patients will be randomized to receive either neostigmine or sugammadex for reversal of rocuronium-induced neuromuscular blockade. a standardized anesthetic protocol that is usual and customary for the type of operation the patient is having will be provided to the anesthesia teams of enrolled subjects. the remainder of the anesthetic care of the subject will not deviate from the standard of care. to account for protocol deviations and patient dropout, up to 250 randomization envelopes will be made and enrollment will continue until there are 230 completed enrollments.

objective: to determine the incidence of postoperative urinary retention after reversal of rocuronium-induced neuromuscular blockade by neostigmine versus sugammadex in patients undergoing laparoscopic cholecystectomy. hypothesis: subjects who are reversed with sugammadex will have less postoperative urinary retention compared to subjects who are reversed with neostigmine.

Eligibility criteria:
inclusion criteria: * 18-80 years old * undergoing laparoscopic cholecystectomy * anticipated surgical duration \<2 hours * asa physical status classification 1-3 * willing and able to consent in english or spanish * no personal history of neuromuscular disease exclusion criteria: * preoperative urinary catheter * history of problems with urination * current use of anticholinergic medications (e.g., antihistamines, phenothiazines, antidepressants, antipsychotics) * current uti or urogenital problem (incontinence, known bladder retention, prostate hypertrophy) * planned intraoperative insertion of a urinary catheter * esrd (grf \<30 ml/min) * esld (ast or alt \> 3x reference range) * planned postoperative intubation/ventilation or admission to icu * allergy to sugammadex, neostigmine, glycopyrrolate, or rocuronium * pregnant or nursing women * "stat" (emergent) cases * known or suspected neurological condition (e.g., alzheimer's, h/o of stroke, multiple sclerosis, parkinson's) * patients on toremifene (a selective estrogen receptor modulator) * women on oral contraceptives who do not wish to use a non-hormonal method of contraception for 7 days following surgery
exercise changes to peripheral blood mononuclear cells in children

Conditions: Physical Fitness; Obesity; Child Development; Growth

Summary: the goal of this research is to determine how the peripheral immune system is altered by exercise and differences related to gender, pubertal status and health.

specific aims: 1. to systematically measure for the first time in healthy children and adolescents the effects of brief bouts of exercise on: 1. numbers of circulating pmbcs, their subsets and key intercellular adhesion molecules (icams). 2. pbmc gene regulation of stress, inflammatory, and growth/repair mediators \[including: interleukin-4 (il-4), il-6, il-10, tumor necrosis factor-alpha (tnf-alpha), interferon-gamma), growth hormone (gh), insulin-like growth factor-i (igf-i), heat shock proteins (hsp)\]. 3. circulating (serum) and intracellular pbmc levels of key mediators by flow cytometry and cell culture techniques. 4. circulating endogenous triggers of pbmc mediator responses-soluble hsp, il-6, and f2-isoprostanes. 2. to determine how the acute pbmc responses are altered by gender, pubertal status, body composition (measured by whole-body and regional dexa), and fitness (measured by progressive cycle ergometry and gas exchange). 3. to determine the relationship in healthy children and adolescents among acute pbmc responses to exercise, biochemical precursors of the metabolic syndrome (insulin, glucose, lipids), and the balance of the th1/th2 immune response.

Eligibility criteria:
inclusion criteria: * appropriate tanner stage * no evidence of disease or disability exclusion criteria: * no use of antiinflammatory medications, alcohol, illegal drugs or bronchodilators * elite children participating in extensive exercise or dance programs * pregnant