Kornimate/medical-research-clean huggingface dataset:
aquatic exercises vs core strengthening on disability, flexibility and postural stability in weightlifters.

Conditions: Hydrotherapy; Core Stability; Resistance Training; Low Back Pain

Summary: the study is randomized and single blinded.ethical approval is taken from ethical committee of riphah international university, lahore. participants who meet the inclusion criteria will be enrolled and allocated in group a and group b through sealed envelope method by non probability convenient random sampling technique. subjects in group a will receive aquatic exercises. group b will receive core strengthening.

the objective of the study is to determine the effects of aquatic exercises verses core strengthening on disability, flexibility and postural stability in weightlifters with chronic low back pain. the study is randomized and single blinded. ethical approval is taken from ethical committee of riphah international university lahore. participants who meet the inclusion criteria will be enrolled and allocated in group a and group b through sealed envelope method by non probability convenient random sampling technique. subjects in group a will receive aquatic exercises. group b will receive core strengthening. the outcome measures will be assessed by modified oswestry low back disability index , modified finger_tip to floor method and new york posture rating chart. the data will be analyzed by spss, version 25. statistical significance is p=0.05.

Eligibility criteria:
inclusion criteria: * age of participants between 20-35 years * experienced male weightlifters from past 6 months to in practice. * participants must have chronic low back pain for at least three months before enrollin exclusion criteria: * patients with significant back pain who need rapid medical or surgical treatment. * history of respiratory or heart diseases * water related anxiety or inability to adapt to aquatic environment. * participants with prior back surgery i.e. had surgery within six months.

Keywords: aquatic exercises core strengthening weightlifters chronic low back pain
prospective cohort study on prognosis of patients with hepatitis b/c

Conditions: Hepatitis B; Hepatitis C

Summary: hepatitis b (hbv) and hepatitis c (hcv) are prevalent all over the world, which seriously threatens public health. in 2016, the world health organization(who) put forward the goal of eliminating the threat of viral hepatitis to public health by 2030. however, at present, the diagnosis rate and treatment rate of chronic hbv and hcv in china are still far from the goal put forward by who. therefore, for china, the elimination of viral hepatitis is still a public health problem that needs a long time to face. this study aims to screen and follow up hbv and hcv patients in danzhou city, hainan province, so as to understand the epidemiological characteristics and long-term prognosis of hbv/hcv patients.

hepatitis b (hbv) and hepatitis c (hcv) are prevalent all over the world, which seriously threatens public health. according to the survey, there are about 93 million chronic hbv infected people and 10 million chronic hcv infected people in china, accounting for 36.19% and 14.08% of the global hbv and hcv infected people respectively. chronic hbv and hcv infection is the main cause of liver cirrhosis and liver cancer, which places a great burden on the national economy. in 2016, the world health organization(who) put forward the goal of eliminating the threat of viral hepatitis to public health by 2030, including 90% diagnosis rate, 80% treatment rate and 90% cure rate of viral hepatitis, in order to reduce 65% of viral hepatitis related deaths and reduce the disease burden. however, at present, the diagnosis rate of chronic hbv in china is 18.7%, the treatment rate is 10.8%, the diagnosis rate of chronic hcv is 30%, and the treatment rate is 9%, which are still far from the goal put forward by who. therefore, for china, the elimination of viral hepatitis is still a public health problem that needs a long time to face. this study aims to screen and follow up hbv and hcv patients in danzhou city, hainan province, so as to understand the epidemiological characteristics and long-term prognosis of hbv/hcv patients.

Eligibility criteria:
inclusion criteria: * hbsag/hbv dna positive * or anti-hcv/hcv rna positive exclusion criteria: * patients who refused to participate in the study.
the effect of lavender essential oil on birth pain

Conditions: Labor Pain; Aromatherapy

Summary: the study was planned as a randomized controlled trial to determine the effect of lavender oil applied to primiparous women by inhalation and massage methods on labor pain.

in universe of the research; pregnant women who applied to adana seyhan state hospital's marsa gynecology and obstetrics additional service building and obstetrics service and delivery room between the dates of the study, accepted to participate in the study voluntarily and who met the research conditions included. numbers 1-2 of a 6-sided dice determined by the dice rolling system formed the control group (40 pregnant), numbers 3-4 were lavender oil inhalation group (44 pregnant), and numbers 5-6 were lavender oil massage group (37 pregnant). the research was carried out in three stages for the experimental groups and control groups. first stage; informed voluntary consent form and questionnaire were applied to the pregnant women whose groups were determined by the chosen randomization method. afterwards, for the experimental groups according to the group; 10-minute training sessions were given on the inhalation method or massage method with aromatic lavender essential oil. in the second stage; data were recorded by dividing the first phase of labor into 3 phases for each group. visual analog pain scale and mcgill melzack pain questionnaire were applied to the experimental groups 6 times, before and 30 minutes after the application. at this stage, no application was made in the control group, the visual analog pain scales and mcgill melzack pain questionnaire were applied at the beginning of each phase, the same forms were repeated after 30 minutes and the data were recorded 6 times in total. in the third stage; in the postpartum period, the study was completed by applying the postpartum period information collection form by face-to-face interviews with the experimental groups and the pregnant women in the control group.

Eligibility criteria:
inclusi̇on cri̇teri̇a: * single pregnancy * primiparous gestational age more than 36 weeks (term) * cervical dilatation of at least 3 cm * pregnants with 3 uterine contractions in a 10-minute period lasting at least 30 seconds * cephalic presentation * not receiving analgesics, sedatives or anesthetics during labor, * not using induction at birth exclusi̇on cri̇teri̇a: * multiparity * cephalopelvic incompatibility * third trimester bleeding history * intrauterine growth retardation * multiple pregnancy * breech presentation * subject's withdrawal from clinical trial * allergy to aromatic lavender essential oil * addiction (alcohol, smoking) * obstetric conditions requiring emergency cesarean section * infertility history * previous history of diagnosis of an underlying disease * induction at birth

Keywords: labor pain aromatherapy, lavender essential oil aromatherapy with lavender essential oil
the covid-19 icu prayer study

Conditions: Coronavirus Infection

Summary: this is a multicenter; double blind randomized controlled study investigating the role of remote intercessory multi-denominational prayer on clinical outcomes in covid-19 + patients in the intensive care unit. all patients enrolled will be randomized to use of prayer vs. no prayer in a 1:1 ratio. each patient randomized to the prayer arm will receive a "universal" prayer offered by 5 religious denominations (christianity, hinduism, islam, judaism and buddhism) in addition to standard of care. whereas the patients randomized to the control arm will receive standard of care outlined by their medical teams. during icu stay, patients will have serial assessment of multi-organ function and apache-ii/sofa scores serial evaluation performed on a daily basis until discharge. data assessed include those listed below.


Eligibility criteria:
inclusion criteria: * male or female greater than 18 years of age * confirmed positive for covid-19 * patient admitted to intensive care unit exclusion criteria: * patients admitted to icu for diagnosis that is not covid-19 positive.
parecoxib versus celecoxib versus oxycodone in pain control for transcatheter chemoembolization procedure

Conditions: Liver Cancer; Pain Postoperative

Summary: this phase iii, randomized, prospective clinical study, aiming to compare the analgesic effects of celecoxib, parecoxib, and oxycodone in patients with inoperable hepatic carcinoma undergoing tace procedure in postoperative pain control.

studies reported that almost 75% of patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolization (tace) experienced severe pain (in a three-grade mild, moderate, and severe classification), and 93% of patients required opioid treatment during the first 12 hours after tace. opioids and nonsteroidal anti-inflammatory drugs (nsaids) are most commonly used analgesic medications in the control of postoperative surgical pain. previous studies has indicated that both controlled-release oxycodone, which is an oral semisynthetic opioid µ and κ agonist, and parecoxib sodium, a parenteral cox-2 selective inhibitor, were effective and safe on peri- and post-procedural pain in hcc patients undergoing tace. to the investigators's knowledge, no studies have been developed on comparing differences of efficacy and feasibility of analgesics with different action mechanism (opioids vs. nsaids) and administration route (oral path vs. injective path) on pain control for patients undergone tace. in this phase iii, randomized, prospective clinical study, the investigators aimed to compare the analgesic effects of celecoxib (oral nsaids), parecoxib (injective nsaids), and controlled-release oxycodone (oral opioids) in patients with inoperable hepatic carcinoma undergoing tace procedure in postoperative pain control.

Eligibility criteria:
inclusion criteria: * patients included in the study were classified with stage b or c according to the barcelona clinic liver cancer (bclc) staging classification. * patients were recommended to receive tace therapy for hcc. exclusion criteria: * hypersensitive to celecoxib, parecoxib, and oxycodone * a history of serious allergic reactions to medicines * stomach ulcers or bleeding in the stomach or gut * allergic-type reactions such as bronchospasm, cold-like symptoms, polyps in the nose, swelling of the face or hives after taking aspirin or nsaids, including other cox-2 inhibitors * severe liver disease * inflammatory bowel disease * heart failure, ischaemic heart disease, peripheral artery disease, or cerebrovascular disease * women during the last three months of pregnancy or to breast-feeding women * after coronary surgery

Keywords: pain control tace opioids nsaids
excel: change in cardiometabolic disease risk factors during an interactive fitness program

Conditions: Cardiovascular Disease

Summary: childhood obesity has increased in prevalence over the past several decades and is predictive of adult type 2 diabetes and cardiovascular disease (cvd). recent studies of children and youth suggest that exercise reduces cardiometabolic risk factors. minimal data are available, however, on the effects of "exergaming" , interactive technology- mediated approaches to increasing physical activity in children and youth. this project involves a partnership between umass boston/gokids boston and children's hospital boston featuring an interdisciplinary team of researchers and clinicians from pediatric cardiology, nursing, prevention and behavioral sciences and exercise physiology and is designed to examine the effects of exergaming on moderate or vigorous physical activity (mvpa) indices of adiposity, risk factors for cardiometabolic disease and self-competence in boston public school children. it is hypothesized that participation in the excel/exergaming intervention for 60 minutes, three times per week for 12 weeks will significantly increase mvpa (as measured by accelerometers), pre- to- post intervention and compared to an advice only (nutrition education) group.results of this pilot study will guide and inform a larger study of exergaming in children from the boston public schools.


Eligibility criteria:
inclusion criteria: * enrolled in grades 3-5 * able to attend gokids and school-based weekly educational sessions for 12 weeks and complete baseline and follow-up testing * informed consent from a parent or legal guardian and written assent from the child * english speaking child * free from medical conditions that would prohibit exercise as indicated by permission to participate in school physical education, and by review of screening questions with clearance from primary care provider as necessary. exclusion criteria: * abnormalities on screening/baseline evaluation that could pose a significant risk for exercise * illness that would limit participation * plans to move out of the area or change schools in the next 6 months

Keywords: physical activity cardiometabolic risk children
phytotherapy strategy for sleep disorders related to anxiety with a combination of eschscholtzia and valerian extracts

Conditions: Sleep Disorders Related to Anxiety

Summary: the aim of the study is to evaluate the effect of a one-month supplementation with phytostandard® eschscholtzia and valerian on the insomnia severity index (isi), in insomniac so-called adjustment subjects (occasional or short-term insomnia)

for this study, 40 patients are going to be included. they will have a supplementation of phytostandard® eschscholtzia and valerian, from 2 to 4 tablets per day during 28 days. on the one hand, during the two visits (inclusion and follow-up), the investigator completes the hamilton anxiety scale (ham-a). during the inclusion visit, he completes with his patient the epworth scale. on the other hand, patients complete isi twice : just after the inclusion visit and just before the follow-up visit. he completes two sleep schedules, the first one during the first week of complement and the second one during the fourth.

Eligibility criteria:
inclusion criteria of patients: * currently having sleep disorders related to an anxiety and / or having some in the last 3 months * having an alteration of sleep on the previous month which results in a score strictly greater than 7 according to the index of severity of insomnia (isi) * for which the investigator freely advises his patient a complement with phytostandard® eschscholtzia and valerian * for which the patient freely agrees to complement itself after advice of his doctor with phytostandard® eschscholtzia and valerian * having been informed of the study and accepting the collection and processing of their data exclusion criteria: * suffering from an anxiety resulting in a ham-a score (hamilton anxiety rating scale) greater than or equal to 30 * with a score on epworth's sleepiness scale strictly greater than 10 (suggestive of a major hypersomnia) * presenting symptoms of sleep apnea syndrome * presenting symptoms of a restless legs syndrome * presenting a chronic pain syndrome requiring the daily intake of analgesic(s) * under psychotropic treatment (neuroleptic, anxiolytic, antidepressant or hypnotic) or under treatment to alter the waking state (antihistamines, beta-blockers, some cough syrups, etc.)
study of darifenacin in patients suffering from multiple sclerosis and neurogenic detrusor overactivity

Conditions: Multiple Sclerosis; Overactive Detrusor

Summary: the objective of this study is to explore the effects of darifenacin in patients with multiple sclerosis and neurogenic detrusor overactivity. the efficacy, safety and tolerability of darifenacin are already well established in idiopathic detrusor overactivity. patients with multiple sclerosis and neurogenic detrusor overactivity without detrusor-sphincter-dyssynergia (dsd) will be allocated to darifenacin therapy.


Eligibility criteria:
inclusion criteria: * patients with multiple sclerosis for at least 6 months * neurogenic detrusor overactivity without dsd * symptoms of oab * patients capable of completing the bladder diary * patients capable of independent toileting * patients able to swallow the study medication in accordance to the protocol * body mass index \>/= 18,8 kg/qm and \</= 35,0 kg/qm * documented, dated, written informed consent exclusion criteria: * treatment with drugs known to affect mainly the urinary function 14 days prior to starting completion of the baseline diary for visit 2 * participation in a bladder-training program * low compliance bladder (compliance \<20 ml/cm h2o) * dsd, detrusor hyporeflexia / areflexia and bradykinesia / tremor of the external urethral sphincter * indwelling catheter or intermittent self-catheterization * patience with post-void residual (pvr) urinary volume \> 200 ml at baseline * urinary retention or clinically significant bladder outlet obstruction as detected by the investigator * clinically predominant and bothersome stress urinary incontinence * neurological diseases other than multiple sclerosis affecting urinary bladder function * any urogenital surgery within 12 month prior to visit 1 * 17 additional exclusion criteria

Keywords: darifenacin multiple sclerosis open label study
radial shockwave for spasticity in children with cp or abi

Conditions: Spasticity Due to Cerebral Palsy; Spasticity Post-Traumatic Brain Injury

Summary: the goal of this clinical trial is to determine if radial extracorporeal shockwave therapy (reswt) reduces spasticity in children with cerbral palsy (cp) or traumatic brain injury (tbi). the main questions it aims to answer are: * is it feasible to implement radial shockwave therapy in conventional physiotherapy plan in children with cp or tbi? * is it safe and effective to use reswt for reducing spasticity in children with cp or tbi? participants will receive a 4 week therapy intervention, as add on to the conventional physio (usual care), including one reswt session per week for a total of 4 sessions.


Eligibility criteria:
inclusion criteria: * cerebral palsy or acquired brain injury * between 6-18 years old; * gross motor function classification ≥2; * experiencing spasticity in the lower limb (calf muscles, hip adductor muscles or hamstring muscles) and/or in the upper limb (biceps muscle, wrist flexor muscles, finger flexor muscles) with modified ashworth scores (mas) ≥1+. exclusion criteria: * recent (≤3 months) botox injections or other recent (≤6 months) invasive intervention; * local infections or wounds; neuropathy; * severe organ dysfunction; * severe psychosocial dysfunction that would not allow adhering to protocol; * planned changes in medication dosage or medication scheme that might affect spasticity during a 4-month intervention and follow-up phase.

Keywords: extracorporeal shockwave therapy shockwave therapy shock wave therapy children radial shockwave therapy
percutaneous kyphoplasty using rotary cutter in osteoporotic vertebral fractures

Conditions: Spine Fracture

Summary: kyphoplasty(pkp) is performed under general anaesthesia in patients with osteoporotic vertebral compression fracture. the balloon is first placed into the fractured vertebra and inflated with contrast agent for height restoration. then, the cement is injected into the cavity created by the balloon. as the diffusion of cement can be interfered by closely barriers formed by surrounding cancellous bones, refractures are often found in patients with conventional pkp. furthermore, the loss of restored height of surgical vertebrae due to refracture in pkp. the investigators will applied a rotary cutter to destroy the structure of the cavity created by the balloon. finally, the cement is injected, which may effectively interdigitates with the surrounding cancellous bone.


Eligibility criteria:
inclusion criteria: 1. patient is able to undergo the vertebroplasty or balloon kyphoplasty procedure 2. patient has read and sign the informed consent 3. male or female, 50 years or older 4. compressive and burst vertebral body fractures without any neurological deficit. 5. persistent pain despite medical treatment according to vas ≥ 5 or a last resort to morphine treatment exclusion criteria: 1. neurological signs related to the vertebral fracture to treat 2. unmanageable bleeding disorder 3. history of surgical or percutaneous spine treatment except simple discectomy at a single or multiple vertebral levels with no residual pain. 4. known allergy to bone cement 5. local or generalized infection 6. improvement of the symptoms of the patient with conservative management

Keywords: fractures, compression back pain bone cements kyphoplasty
evaluation of 3d imaging ulcer camera

Conditions: Diabetes Mellitus; Diabetic Foot Ulcer; Wound; Chronic Disease

Summary: the aim of the study is to evaluate the intra- and inter-rater variability of wound measurements using the 3d camera and to compare with standard measurement methods (2d image method and gel injection). forty-eight patients with wounds of various sizes are measured by four clinicians. each wound is measured twice with the 3d camera, once by 2d image method and once by gel injection into wound cavity by two clinicians.

diabetic foot ulcers constitute an increasing health problem in denmark concurrent with an ageing population and an increase in diabetes prevalence. diabetic foot ulcers belong to the most serious and costly complications. several studies have found that the size and depth of the wound is one of the major etiologic factors for delayed healing. wound measurement is important in monitoring the healing process of wound and in evaluating the effect of treatment. three-dimensional methods for measuring wound size have made it possible to evaluate the process of wound healing with respect to all dimensions. the investigators have developed a 3d camera, which is able to measure wound size (2d area, 3d area, perimeter and volume) and to assess wound characteristics. the aim of the study is to evaluate the intra- and inter-rater variability of wound measurements using the 3d camera and to compare with standard measurement methods (2d image method and gel injection). forty-eight patients with wounds of various sizes are measured by four clinicians. each wound is measured twice with the 3d camera, once by 2d image method and once by gel injection into wound cavity by two clinicians.

Eligibility criteria:
inclusion criteria: * patients with wounds * 18 years or older exclusion criteria: * superficial ulcer (less than 5x5 mm with no substantial loss of subcutaneous tissue) * non-compliance (dementia, mental disorders)

Keywords: diabetic foot ulcer measurement wound healing measurement device three-dimensional measurements