Kornimate/medical-research-clean huggingface dataset:
mindfulness for parents of ocd-affected children

Conditions: Obsessive-Compulsive Disorder

Summary: the purpose of this study is to investigate the role of a mindfulness-based skills training program for parents of children with obsessive compulsive disorder (ocd). the investigators will explore if parents involved in this group experience any change in their levels of stress, feelings of being an effective parent and family relationships compared to a waiting list control period. the investigators will look at how the family manages ocd in their lives. in particular, if mindfulness skills training will help increase the parents ability to tolerate distress in their child secondary to ocd and as such reduce the family accommodation of ocd. as family accommodation is an important negative prognostic predictor for children with ocd, changes in ocd symptom severity and functional impact in these child will also be measured.

obsessive-compulsive disorder (ocd) is a debilitating psychiatric illness that frequently begins in childhood. it is characterized by obsessions and/or compulsions that are distressing, time consuming and significantly impairing. ocd is distinct in the extent to which it disrupts family functioning, in that there is intense parental pressure to become involved in rituals and to change home environments and schedules to avoid triggers, thus accommodating the ocd. it is also well known that ocd severity tends to worsen in the context of stressful environments and situations. while effective treatment approaches for pediatric ocd have been identified, partial response and treatment refusal are all too common, leading to chronicity of both the illness itself and of its deleterious familial effects. the investigators plan to study a novel approach to help manage the stress of parenting a child with ocd, thus facilitating more effective resistance to ocd family accommodation and supporting the child in fighting this difficult illness. the investigators will explore the role of group-based mindfulness-based skills training (p-mbst) in supporting parents of ocd-affected youth, in particular investigating the possibility that increased distress tolerance as a result of mindfulness practice may help parents reduce ocd accommodation.

Eligibility criteria:
inclusion criteria: 1. parents (or step-parents or legal guardians) with care-giving role for an ocd-affected youth from our clinic 2. participants must be able to converse in english 3. participants willing to attend 8 sessions of a weekly 1.5 hour group, in addition to complete questionnaires at multiple time points during the group and waiting list period. exclusion criteria: 1. parents who have previously participated in mindfulness skills training. 2. parents with active psychosis, mania, mental retardation, autism or current substance misuse. 3. parents unwilling to provide consent. 4. families who are not attending our program's group-family cognitive-behavioral therapy treatment concurrently.

Keywords: mindfulness training parents and families pediatric ocd
fludeoxyglucose f 18-pet/ct scans in patients receiving ultra short-term dexamethasone for lung nodules

Conditions: Pulmonary Nodule

Summary: rationale: imaging procedures, such as fludeoxyglucose f 18 (fdg)-pet/ct scan, done before and after steroid therapy may help doctors assess a patient's response to treatment and help plan the best treatment. purpose: this phase i trial is studying fludeoxyglucose f 18 pet scan performed before and after ultra short-term dexamethasone therapy to see how well it measures changes in nodules in patients with lung nodules.

objectives: * to determine whether ultra short-term steroid therapy (24-48 hours) can be used to increase the accuracy of fludeoxyglucose f 18 positron emission tomography/computed tomography (fdg-pet/ct) imaging in categorizing nodules in patients with pulmonary nodules. * to calculate the overall sensitivity and specificity of the nodules group, based on fdg uptake, for predicting malignancy. * to gather effect-size estimates that will be used to improve the quality of a larger follow-up study. outline: patients receive oral dexamethasone at 40, 28, 16, and 4 hours before imaging. patients undergo fludeoxyglucose f 18 (fdg)-positron emission tomography/computed tomography (pet/ct) imaging at baseline and upon completion of steroid therapy. after completion of study therapy, patients are followed for 6 months.

Eligibility criteria:
disease characteristics: * presence of ≥ 1 measurable pulmonary nodule (1.0-3.0 cm) suggestive of malignancy or chronic inflammatory process on positron emission tomography (pet) scan * no lesions consistent with malignancy or inflammation according to history, pet findings, or biopsy * baseline scan average time between injection and start of scan within 50-70 min * mean liver standardized uptake value (suv) of baseline scan normal * no sign of significant partial paravenous tracer administration in the images of baseline scan * no lung nodule(s) suggestive of lymphoma * no lung lesions suggestive of tuberculosis patient characteristics: * ecog performance status 0-2 * blood glucose levels ≤ 150 mg/100 ml * not pregnant or nursing * fertile patients must use effective contraception * able to tolerate pet/ct imaging * no history of diabetes * no poorly controlled hypertension * no prior malignancy other than basal cell or squamous cell carcinoma of the skin, carcinoma in situ, or other cancer from which the participant has been disease free for \< 3 years * no active malignancy within the past 5 years prior concurrent therapy: * more than 5 years since prior chemotherapy or radiotherapy * no concurrent steroids

Keywords: pulmonary nodule
lower urinary tract symptoms in males living with hiv

Conditions: HIV Seropositivity; Lower Urinary Tract Symptoms

Summary: the primary aim of this study is to learn whether the frequency of lower urinary tract symptoms differ between the males with seronegativity for hiv and males living with hiv.


Eligibility criteria:
inclusion criteria: * patients above 18 years old exclusion criteria: * non-turkish speakers * previous surgeries or medications for lower urinary tract symptoms
efficacy of electroacupuncture versus solifenacin succinate for female overactive bladder

Conditions: Overactive Bladder

Summary: through a scientific and standardized multicenter, blinding, double-dummy, randomized controlled, noninferiority clinical trial study method, the investigators evaluated electroacupuncture as a safe and effective non-pharmacological treatment for oab in women by comparison with solifenacin succinate.

epidemiological researches have shown that approximately 500 million people worldwide are affected by oab, 2 3 with a higher incidence in women than that in men. pharmacological treatment remains the usual method of clinical treatment. however, some pharmacologphy has certain side effects, such as blurred consciousness, dry mouth, constipation, and so on, which have limited its widespread clinical use. therefore, the treatment of oab needs comprehensive consideration in clinical practice, which deserves our attention and active exploration of other effective treatment methods to relieve patients' pain.electroacupuncture can effectively improve the clinical symptoms of oab. as for the comparison between electroacupuncture and medication for the treatment of oab in women, the results are inconclusive based on the limited research evidence. the aim of the study is to investigate the effectiveness and safety of electroacupuncture compared to solifenacin succinate.

Eligibility criteria:
inclusion criteria: * meet the american urological association (aua) diagnostic criteria for adult overactive bladder disorder (non-neurogenic) and the chinese urological association's guidelines for the diagnosis and treatment of urological diseases in china (2014 edition) for oab. * female patients aged 18-75 years. * duration of illness with oab ≥ 3 months. * 3≤oabss≤11. * no abnormality in routine urine tests. * patients had never received acupuncture treatment. * no mental or intellectual abnormalities, able to understand the provisions of the scales and complete the assessment. * consent to participate in this study and sign a written informed consent. exclusion criteria: * combination of more serious heart, liver, kidney and other serious diseases; or patients with severe liver or kidney insufficiency. * patients with pelvic organ prolapse ≥ ⅱ degree, urinary system surgery history or pelvic floor surgery history. * patients with other diseases presenting with oab symptoms. * those with urinary diseases (such as calculi and tuberculosis of the bladder), malignant tumors, and neurological disorders. * patients who are pregnant or breastfeeding. * patients using medication that may affect bladder function one month prior to enrollment or having received behavioural therapy for oab three months prior to enrolment, etc. * patients with pacemakers. * patients with blood diseases, diabetes mellitus or mental diseases. * infections, ulcers, abscesses, and skin infections at needling sites; metal allergy or extreme needle phobia. * participation in other clinical medical trial studies over the last month.
build a research clinic for somatoform patients

Conditions: Somatoform Disorders; Somatic Symptom Disorder

Summary: to investigate the effects of the two following interventions on somatoform patients:1. case management model2. psychotherapy, based on cognitive-behavioral therapy and biofeedback therapy

patients with presentations of somatic symptoms and associated psychological features are named as "somatoform disorders" in psychiatric field. because the patients' concerns are somatic distress, they often seek help in non-psychiatric clinics. however, the symptoms are usually medically unexplained. this group of diagnoses can be managed from the psychiatric perspective, including medications and psychotherapies. however, many patients do not receive psychiatric management in current medical practice. the goal of this project is to establish an association named "psychosomatic center" for providing comprehensive evaluations and treatments to the somatoform patients. besides the psychiatrist, a case manager, a clinical psychologist, and a research assistant will be included in this association for the purposes of connection, performing psychotherapy and examinations. after entering the psychosomatic clinic, the investigators will routinely perform diagnostic interview, measure psychological and physiological features, and arrange individualized treatment program. the investigators will follow the important psychological and biological indexes every 3-6 months for building a cohort. at the same time, the case manager will connect with non-psychiatric clinics for ensuring the patients physical problems to be managed. the investigators expect this project to enhance the quality of treatment on the patients, to reduce the excessive examinations for the frequent attenders, and to improve the emotional burden of medical staffs.

Eligibility criteria:
inclusion criteria: * 1. between 15 and 80 years old * 2. meet the diagnosis of dsm-5 somatic symptom disorder exclusion criteria: * 1. with psychotic symptoms (such as schizophrenia, bipolar disorder with psychotic symptoms) or cognitive impairment * 2. having potentially lethal physical diseases (such as cancer, coronary artery diseases, cerebrovascular diseases; because under this condition, high health anxiety is quite rational. patients with common physical diseases can still enter this trial) * 3. unable to read or understand the questionnaires

Keywords: somatoform disorders somatic symptom disorder psychosomatic medicine medically unexplained symptoms
contrast enhanced ultrasound (ceus) in atypical liver nodules in patients with chronic liver disease

Conditions: Hepatocellular Carcinoma

Summary: the present study aims to investigate the role of ceus in evaluating liver lesions with atypical characteristics on contrast-enhanced ct or mri. all patients enrolled in the study underwent contrast-enhanced ultrasound. based on ceus characteristics, atypical nodules will be categorized according to ceus li-rads classification.

this retrospective study investigates the role of ceus in evaluating liver lesions with atypical characteristics on contrast-enhanced ct or mri. all patients enrolled in the study underwent contrast-enhanced ultrasound. all ceus exams were performed, recorded, and analyzed by two experienced operators (\>10 years of experience with abdominal us and ceus). based on ceus characteristics, atypical nodules will be categorized according to ceus li-rads (lr) classification. if the analyzed nodule shows a typical hallmark on ceus (lr-5), that is arterial phase hyperenhancement with late-onset (\>60 s) washout of mild intensity, it is definitively considered hcc and have been treated appropriately. categories lr-3 and lr-4 comprise nodules with different combinations of arterial and venous phase enhancement features, expected to correspond to an intermediate or high probability of lesions to be hcc. patients with lr-3 or lr-4 nodules underwent follow-up; in some cases they underwent biopsy. lr-m is used to classify high-probability malignant lesions but nonspecific for hcc; these nodules underwent biopsy for further characterization.

Eligibility criteria:
inclusion criteria: * diagnosis of liver cirrhosis or chronic liver disease with increased risk of hcc * diagnosis of atypical nodules on contrast-enhanced ct or mri exclusion criteria: * less than 18 years of age * pregnancy * typical nodules on contrast-enhanced ct or mri * non-visualized nodule on b-mode us * ceus not performed or performed more than three months after ct or mri
social facilitation of alcohol effects and alcohol misuse in young adults

Conditions: Alcohol Consumption; Alcohol Abuse/Dependence

Summary: the purpose of this study is to understand social contexts and alcohol use. we hope to learn how being around peers affects alcohol consumption in young adults. about 250 young adults who drink alcohol frequently will take part in the study. this research is being funded by the national institute on alcohol abuse and alcoholism (niaaa). participation involves one in-person screening session with a same-sex platonic friend. then participants will complete four in-person laboratory sessions where they will drink beverages containing alcohol or no alcohol. after completion of the laboratory sessions, participants will complete smartphone surveys for 28 days. lastly, they will complete follow-up surveys 6 months and 12 months post-study enrollment.


Eligibility criteria:
inclusion criteria: * 21-28 years of age * drink regularly (1+ times/week) with a same-sex platonic friend that also meets eligibility and is willing to participate * regular alcohol use (3+ times/week) with at least one binge drinking episode (5+ drinks \[male\] or 4+ drinks \[female\] in about 2 hours) in the past month * bmi of 18-30 * own a smart device operating on the ios or android operating system * fluent in english exclusion criteria: * pregnancy or breastfeeding or intent to get pregnant in the next 60 days (females) * medical conditions counter-indicated for alcohol administration * seeking treatment for alcohol use
pre-frailty risk in cardiovascular surgery

Conditions: Post Cardiac Surgery

Summary: frailty is an important risk factor for cardiovascular disease (cvd), recent data has shown significant association between pre-frailty and the risk of incident for cvd, irrespective of any classical cardiometabolic risk factors, suggesting that targeting pre-frailty as a potentially reversible risk factor for cvd in the elderly. patients with high levels of frailty have an increased risk in post-operative period, with more time in mechanical ventilation, length of stay and complications (stroke and death) compared to patients with low frailty levels. the investigators hypothesized that pre-frailty patients also have a higher surgical risk compared to no-frailty patients.

this was a prospective observational study involving patients over 65 years recruited from the dante pazzanese institute of cardiology. the patients had an established diagnosis of cardiovascular diseases (myocardial infarction or valve regurgitation) by previous electrocardiogram and/or doppler echocardiography and all had surgical indication (coronary artery bypass, valve replacement or combined surgery). patients with prior neurological disease (previous stroke or muscular dystrophies) or cognitive impairment resulting from previous injury or who refused to participate in the study were excluded. twenty-four hours before the surgery patients were evaluated by frailty score as described elsewhere and divided into 2 groups: no-frailty (frailty score 1 or 2) and pre-frailty (frailty score 3 or 4). if the patient had frailty score higher than 5 were excluded from the study. after surgery all patients were admitted at the intensive care unit (icu) following the institutional mechanical ventilation protocol. immediately after admission heart rate, mean arterial pressure, and oxygen pulse saturation (spo2) were measured with a dixtal monitor (dx 2010). after icu admission all participants were followed up for main outcomes: hospital discharge, stroke, infection or death. in addition the investigators also measured length of stay, the duration of mechanical ventilation, vasopressors usage and the needed of physiotherapy indication after hospital discharge. all study participants receive medical and physiotherapy care according to the routine of the institution.

Eligibility criteria:
inclusion criteria: * cardiovascular diseases (myocardial infarction or valve regurgitation) by previous electrocardiogram and/or doppler echocardiography and all had surgical indication (coronary artery bypass, valve replacement or combined surgery). exclusion criteria: * neurological disease (previous stroke or muscular dystrophies) or cognitive impairment resulting from previous injury or who refused to participate in the study

Keywords: frailty surgery
injection of hyaluronic acid versus corticosteroid for treatment of trigger finger

Conditions: Trigger Finger

Summary: the aim of the study is to compare the therapeutic effects of hyaluronic acid versus steroid injections in treating trigger fingers using ultrasound guidance

a prospective randomized controlled study designed to compare the outcomes of injecting patients with trigger finger with hyaluronic acid versus corticosteroid under ultrasound guidance

Eligibility criteria:
inclusion criteria: * adult (\>18 years) * patients with a clinical diagnosis of trigger finger grade 1-3 on the quinnell grading scale and confirmed diagnosis by ultrasound. exclusion criteria: * quinnell's classification grade iv (contracture) * prior injection within 6 months * prior operation of the affected finger * presence of any contracture in the proximal interphalangeal or metacarpophalangeal joint, and * history of diabetes, hypothyroidism, and * rheumatic or connective tissue disease * allergy to triamcinolone or hyaluronic acid * pregnancy * secondary triggering e.g. trauma, infection * trigger finger symptoms duration \>6 months

Keywords: trigger finger hyaluronic acid corticosteroid ultrasound-guided injection
a pilot study of neoadjuvant chemotherapy combined with bevacizumab for locally advanced rectal cancer

Conditions: Rectal Cancer

Summary: background: neoadjuvant chemoradiotherapy (crt) and total mesorectum excision (tme) has become the standard therapy for the treatment of locally advanced rectal cancer (larc) to reduce the local recurrence rate, however, no improvement of distant metastasis rate was observed, and the incidence of postoperative local recurrence and distant metastasis can reach more than 25%. it is still a challenge for us to improve the ro resection rate of locally advanced rectal cancer and reduce the incidence of local recurrence and distant metastasis.

objective: compared with the postoperative adjuvant therapy, neoadjuvant chemotherapy has shown better compliance of larc patients, and may be more effective in reducing the incidence of local recurrence and distant metastasis. this study used the anti-angiogenesis drugs beacizumab and chemotherapy in patients with larc for neoadjuvant chemotherapy, and investigated the short-term efficacy to provide objective basis for the selection of neoadjuvant therapy. methods: 70 patients with rectal adenocarcinoma clinical staging in stage ii or stage iii were included for neoadjuvant therapy followed by tme, of which 35 underwent neoadjuvant radiotherapy, and other 35 underwent neoadjuvant chemotherapy+beacizumab.

Eligibility criteria:
inclusion criteria: * 1. clinical stage ii or stage iii rectal cancer patients diagnosed by preoperative biopsy pathology report, endoscopic examination report and preoperative abdominal pelvic dynamic contrast enhanced-mri examination (dce-mri); 2. primary tumor lesions within 4\~12 cm from the anus through endoscopic examination; 3. no distant metastasis and intestinal obstruction; 4. no surgical contraindications; 5. can be treated with neoadjuvant chemotherapy confirmed by normal routine examination; 6. informed consent with patients and family members before treatment. exclusion criteria: * history of beacizumab allergy, being treated with other therapy important viscera dysfunction and severe heart disease, including congestive heart failure, arrhythmia beyond the control, long-term drug treatment of angina pectoris, heart valve disease, myocardial infarction, and resistant hypertension; infectious wound and uncontrollable history of mental illness; infectious sexual diseases.

Keywords: neoadjuvant chemotherapy
correlation between central sensitization inventory and posturographic data

Conditions: Central Nervous System Sensitization

Summary: to investigate the use of balance as a screening tool for central sensitization, a condition of the nervous system that is associated with the development and maintenance of chronic pain. this is done by comparing the scores of a gold standard screening tool (the central sensitization inventory) with balance data.

first, subjects will be asked to answer a brief medical questionnaire pertaining their general health status: since some of the subjects will be self-assessed to be "healthy" (no medical examination will be conducted to determine if this is indeed the case), the questionnaire will be used to determine if there are any possible known causes of poor balance performance. the questionnaire will not constitute an inclusion/exclusion criterion, it just has a classification purpose. subjects will then be asked to fill in the central sensitization inventory (csi), scoring each of the 25 items on a scale from 0 (never) to 4 (always). then, subjects will stand for 2 minutes on a compliant surface (a 4" tall foam cushion of known mechanical properties) to "learn" how to stand on it. afterward, they will undergo posturography testing using the extended modified clinical testing of sensory integration in balance (ext_mctsib) protocol: the subjects will be required to stand on a hard or compliant surface in a comfortable posture, feet shoulder width, with eyes open or closed, arms to the side and free to move, gazing forward, and breathing normally, with head straight, turned right or left, flexed or extended.

Eligibility criteria:
inclusion criteria: * adults, self assessed to be in good health, or medically diagnosed with any of the following pathologies: chronic nonspecific low back pain (cnslbp), fibromyalgia (fm), cervicogenic headche (ch), chronic tension type headache (ctt), irritable bowel syndrome (ibs), whiplash associated disorder (wad), temporomandibular disorder (tmd) exclusion criteria: * pregnant women will be excluded, as will be minors

Keywords: balance, postural postural equilibrium chronic pain chronic nonspecific low back pain fibromyalgia cervicogenic headache chronic tension type headache irritable bowel syndrome whiplash associated disorder temporomandibular disorder