Kornimate/medical-research-clean huggingface dataset:
effect of real-world tight control management of inflammatory bowel disease

Conditions: Inflammatory Bowel Diseases

Summary: inflammatory bowel disease, which includes crohn's disease and ulcerative colitis, is a condition that causes inflammation in the gastrointestinal tract. the disease goes through periods of remission and flare. biomarkers such as fecal calprotectin have been proposed as a tool to monitor disease activity. fecal calprotectin is a test that measures the amount of inflammation in the stool. monitoring fecal calprotectin levels can assist gastroenterologists in making decisions regarding patients' ibd treatment such as whether to increase the dose of medications. a recent study showed that frequent measurement of fecal calprotectin every 3 months, also called the tight-control strategy, was associated with improved clinical outcomes in ibd patients. the purpose of this study is to assess whether the tight-control monitoring strategy, which includes fecal calprotectin monitoring every 3 months, improves clinical outcomes in ibd when performed in the real world compared to routine clinical practice.


Eligibility criteria:
inclusion criteria: 1. diagnosis of crohn's disease or ulcerative colitis based on clinical, endoscopic, radiologic or histologic criteria. 2. followed by a gastroenterologist at hamilton health sciences, st. joseph's healthcare hamilton, and london health sciences 3. aged 18 or older 4. in clinical remission according to the clinical symptom assessment (partial mayo score \< 2 or harvey-bradshaw index \< 4) 5. currently treated with adalimumab exclusion criteria: 1. current abdominal abscess 2. inability or unwillingness to provide informed consent 3. any other condition, which in the opinion of the investigators would impede competence or compliance or possibly hinder completion of the study
operative versus non-operative treatment of clavicle fracture in polytrauma

Conditions: Clavicle Fracture; Chest Injury

Summary: about 90% of chest injuries in america are due to blunt forces, mostly as a result of motor vehicle collisions and falls. severity varies from minor bruising to severe chest injuries. for several years, clavicle ("collarbone") fractures have been treated without surgery (non-operatively), even when the fracture is out of place (displaced). over the last few years, however, treatment has changed more towards surgical fixation (operative), because of the sometimes difficult healing in clavicle fractures that are displaced. several research studies have shown that cases in which the clavicle fracture never heals completely (non-union) are more frequent after nonoperative treatment, compared to operative fixation. in those cases, surgery is still required, only later (secondary surgery). further, clavicle malunion, in which the fracture heals but is still out of place) has been shown to be high after nonoperative treatment. recent published research studies have shown better function, higher patient satisfaction, earlier return to activity (use of the arm) and decreased nonunion and malunion following surgery, also called open reduction/internal fixation. despite recent published research, there is still a lack of agreement on when surgical fixation should be performed for clavicle fractures. patients with chest injuries often have clavicle fractures. chest injuries can restrict patients' ability to breathe, cough, stand, walk and leave the hospital. although it is unusual that chest injuries can be improved with surgery, patients with clavicle fractures and chest injuries might recover faster if the clavicle fractures were repaired. patients are being asked to take part in the study they have sustained a clavicle fracture associated with a chest injury with or without any other injury to the abdomen, or arms or legs. the aim of this study is to determine the difference in the hospital length of stay, intensive care unit length of stay, respiratory rehabilitation (recovery of good respiratory function), functional outcome, ability to become mobile again, complications and risk of dying in trauma patients with chest injury and clavicle fracture treated operatively versus non-operatively.


Eligibility criteria:
inclusion criteria: 1. patients males and females of any race. 2. patients between ages 18 and 80 3. patients who present with a unilateral clavicle fractures which are \>2cm displaced, \>2cm shortened, significantly comminuted, or are tenting the skin or which are bilateral and with associated chest injury and with or without additional injuries to the abdomen, pelvis or extremities will be approached for the study. exclusion criteria: 1. severe brain injury (gcs less than or equal to 13) 2. intubated patients 3. injury precluding operative fixation within 7 days of admission 4. open clavicle fracture 5. spinal cord injuries 6. age \<18 or greater than or equal to 80

Keywords: clavicle fracture fixation polytrauma clavicle fracture patients with chest injury
comparison between two different technique in treatment of chronic pilonidal disease

Conditions: Pilonidal Disease

Summary: comparison between limberg flap and karydakis flap for treatment of pilonidal disease.

the authors prospectively studied patients with sacrococcygeal pilonidal disease (spd) at mansoura university hospital, mansoura, egypt, .patients were randomly assigned to undergo either limberg rhomboid flap or karydakis flap reconstruction . the follow-up period ranged from 8 months to two years, with the mean follow-up period about 18 months. surgical findings, complications, recurrence rate and degree of patient satisfaction were compared. this a randomized controlled study to evaluate both rhomboid excision and limberg flap closure versus karydakis flap for treatment of chronic pilonidal disease. karydakis flap reconstruction was performed in conformity with the original procedure described by karydakis. the technique consisted of a vertical eccentric elliptical incision carried down to the post sacral fascia, complete removal of unhealthy tissue with the normal tissue around the cyst and sinus tracts, mobilization of the medial wound edge by undercutting the adipose tissue at a depth of 1 cm, the advancement of the flap across the midline to the post sacral fascia and suturing of its edge to the lateral one. lamberg flap technique: the area to be excised was mapped on the skin in a rhomboid form . the skin incision was deepened to the presacral fascia centrally and to the gluteal fascia laterally. after removing the specimen, the limberg fasciocutaneous flap was prepared by extending the incision down to and through the right gluteus maximus fascia (fig3a). the size of the prepared flap was equal to that of the rhomboid area. meticulous hemostasis was accomplished by electrocauterization. the fasciocutaneous flap was transposed medially so that the defect would be covered without any tension. sutures were placed between gluteus fascia of the flap and presacral fascia with 2/0 polyglactin to prevent dead space

Eligibility criteria:
inclusion criteria: * patints with pilonidal sinus exclusion criteria: * pilonidal abscess

Keywords: pilonidal disease pnd
a study of circulating immune cell activity changes in blood of colorectal cancer patients

Conditions: Colorectal Cancer

Summary: previous studies have shown that colorectal cancer patients' prognosis and overall survival was related with immune cell expression in patients' tissue. however, the circulating immune cell activity changes in patients' blood has few studies. the purpose of this study is to analyze the variation of circulating immune cell activity in colorectal patients' blood which is classed as clinical staging.

the patients were classed as clinical staging 1. early (stage1+2) and late(stage3+4) 2. regional lymph node metastasis 3. distant metastasis 4. tnm stage

Eligibility criteria:
inclusion criteria: * patient who was planned to undergo colorectal cancer surgery. exclusion criteria: * age \< 20 years old * history of hypersensitivity reaction in propofol or sevoflurane * history of previous cancer * patient with ongoing inflammation
mechanisms of somatic mutation and tumor initiation in pre-malignant kidney tubule cells

Conditions: Carcinoma, Renal Cell; Von Hippel-Lindau Disease

Summary: the goal of this observational study is to analyze somatic mutations in the genome of normal kidney cells from patients affected by kidney cancer predisposition syndrome von hippel lindau (vhl) and compare the mutation rates observed in these patients and in individuals not affected by the disease. the main questions the study aims to answer are: * do kidney cells from vhl patients mutate more than cells from control individuals during adult life? * what mechanisms favor somatic mutation occurrence in the genome of normal kidney tubule cells? participants will donate one blood sample and multiple urine samples. urines will be used for kidney cell isolation, followed by cell culturing and genetic analyses. urine samples will be collected once a year for 3-5 years. sample collection will occur during the yearly screening program that each patient undergoes at the hospital. in case patients undergo surgical treatment of kidney tumors, samples discarded from surgery (tumor and normal kidney adjacent to tumor) will be collected and subjected to genetic analyses. researchers will compare the number and types of mutations found in tumors and normal kidney cells from vhl-disease patients with those found in normal kidney cells from control individuals, to see if somatic mutation rates are increased in vhl-disease patients during aging.


Eligibility criteria:
inclusion criteria: * genetic diagnosis of vhl-disease; age (data need to be collected from a population distributed between 25 and 65 years); gender (males and females should be equally represented); exclusion criteria: * patients with bilateral nephrectomy, in dialysis or kidney transplant; use of nephrotoxic drugs

Keywords: somatic mutations whole genome sequencing normal kidney
turkish version of the qor-15 for emergency laparotomy

Conditions: Quality of Life; Anesthesia; Surgery; Postoperative Complications

Summary: patient perceived quality of recovery is an important outcome after surgery and should be measured in clinical trials. the qor-15 was designed to measure quality of recovery postoperatively. it provided an efficient evaluation of the postoperative quality of recovery. the primary objectives of this study is validate the turkish version of qor-15 questionnaire for emergency laparotomy. the investigators will test its validity, reliability, responsiveness, and clinical acceptability and feasibility, with patients emergency laparotomy, in the university of health sciences, gülhane education and training hospital ankara, türkiye.

recovery from surgery is a complex process that can vary depending on the patient and the anesthesia used. most clinical studies are interested in reducing perioperative morbidity and mortality, but few evaluate the overall recovery process. the qor-15 questionnaire assess recovery after elective surgery. a turkish translation of the qor-15 score has been validated for use in scheduled surgery. this scale, regardless of the language in which it is translated, has been developed and validated in patients who have undergone scheduled surgery. until now, no validated scoring tool has been available to assess recovery after emergency laparotomy.

Eligibility criteria:
inclusion criteria: * ≥ 18 years old, * turkish speaking, * admitted for any type of emergency laparotomy (time to surgery \< 72 hours) * able to answer the questionnaire at hospital admission, alone or with the help of a third party * and agreeing to participate in the study. exclusion criteria: * patients with psychiatric or neurological pathologies that compromise cooperation with the protocol, * patients admitted for revision surgery, * aged \< 18 years old * not agreed to provide written informed consent to participate
culturally tailored educational and support program to increase quality of life among korean breast cancer survivors

Conditions: Breast Cancer

Summary: the objective of the together (together overcome and get empowered through health education and relationships) program was to examine the effectiveness of one of the first linguistically and culturally tailored intervention programs to increase quality of life among korean american breast cancer survivors.

this study employed a randomized trial design, consisting of a standard and enhanced intervention group. participants attended seven weekly sessions and one follow-up session that lasted for about 2 hours each. all sessions were conducted by two korean female bilingual licensed clinical psychologists. the specific aims of this study were to: (1) implement and evaluate the effects of tailored intervention on perceived stress, coping and quality of life among korean american breast cancer survivors; and (2) conduct a process evaluation to assess the feasibility and fidelity of the intervention, which will provide data that can inform the development of future interventions.

Eligibility criteria:
inclusion criteria: * living in maryland, northern virginia, or the washington d.c. metropolitan area * have been diagnosed with breast cancer * have had surgery, completed treatment within the last two years, or still receiving adjuvant therapies exclusion criteria: * unable to understand korean

Keywords: breast cancer korean americans survivorship quality of life coping skills perceived stress
bariatric surgery and pharmacokinetics of lisdexamphetamine

Conditions: Obesity, Morbid

Summary: changes to gastric ph, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. these factors are potentially influenced by bariatric surgery. little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. in this study the pharmacokinetic effects of bariatric surgery on lisdexamphetamine are investigated.


Eligibility criteria:
inclusion criteria: * preparing to undergo gastric bypass or sleeve gastrectomy in central norway * being a norwegian citizen exclusion criteria: * having previously undergone resections in the gi-tract

Keywords: bariatric surgery gastrointestinal tract biological availability pharmacokinetics lisdexamfetamine dimesylate
clinical comparison of ddt2 contact lens and a daily disposable contact lens - study 1

Conditions: Refractive Error; Myopia

Summary: the purpose of this study was to evaluate visual acuity at distance when wearing ddt2 contact lenses compared to acuvue moist contact lenses.

subjects were expected to attend 3 study visits and wear study lenses for approximately 14 - 20 days (7 - 10 days for each product).

Eligibility criteria:
key inclusion criteria: * able to understand and sign an informed consent form that has been approved by an institutional review board. * willing and able to attend all scheduled study visits as required per protocol. * current wearer of spherical soft contact lenses. key exclusion criteria: * any ocular condition that contraindicates contact lens wear. * previous or current habitual wearer of acuvue® moist or dailies total1® contact lenses.

Keywords: visual acuity va daily disposable contact lenses
effect of cranberry capsules on urinary infection rates in spinal cord injured patients during post acute rehabilitation

Conditions: Spinal Cord Injury; Urinary Tract Infection; Rehabilitation

Summary: the purpose of this study is to establish whether cranberry capsules reduce rates of urinary tract infections during initial rehabilitation immediately after spinal cord injury.


Eligibility criteria:
inclusion criteria: 1. previously essentially healthy 2. newly acquired spinal cord injury, t12 level or higher 3. receiving in-patient care on the rehabilitation ward. 4. expected admission duration \>= 4 weeks 5. 16 years old or older exclusion criteria: 1. current or previous disorder that increases the risk of urinary tract infection including diabetes, urological disorder, previous operation on urinary tracts or kidneys, immune dysfunction 2. severe head injury with impairment of cognitive function 3. allergy to cranberry 4. renal failure 5. warfarin (coumarin) treatment with unstable inr 6. current symptomatic urinary tract infection

Keywords: urinary tract infection prevention rehabilitation spinal cord injury
analysis of the radiation safety climate in the hybrid angiography suite

Conditions: Healthy Volunteers; Aortic Aneurysm, Abdominal

Summary: this study aims to measure the radiation safety climate in the hybrid angiography suite using self-assessment and to investigate the relationship of radiation safety climate with their self-reported safety behaviors. the hypothesis is that a radiation safety climate does exist and can be measured using self-assessment. additionally, it is expected that the radiation safety climate positively influences radiation safety behaviors.

radiation safety in the hybrid angiography suite is a primordial safety component which is relevant for endovascular team members and patients. to date, many interventions which aim to improve radiation safety habits of an endovascular team focus on improving technology and team radiation safety knowledge. safety literature has indicated that a safety climate can be identified as the shared perceptions of team members or workers about the safety in their workspace and that this safety climate is closely related to safety behaviors and outcomes. in endovascular specialties, the concept of a radiation safety climate remains unexplored. therefore, this study aims to measure the radiation safety climate in a diverse pool of endovascular team members from different hospitals, using self-assessment questionnaires and to investigate the relationship of radiation safety climate with their self-reported safety behaviors.

Eligibility criteria:
endovascular team member group inclusion criteria: * vascular surgeon or surgical trainee or operating nurse * active at one of the participating hospitals exclusion criteria: * no exclusion criteria apply to this study. patient group inclusion criteria * patient undergoing elective endovascular repair of infrarenal abdominal aortic aneurysm exclusion criteria * emergency repair (ruptured aneurysm) * additional interventional procedures (iliac aneurysm, treatment of peripheral vessel disease)

Keywords: radiation safety radiation safety climate radiation safety behavior quality improvement patient safety
dry needling effectiveness and post-punction pain

Conditions: Neck Pain

Summary: the purpose of this estudy was to dertermine if the application of transcutaneous nerve stimiulation (tens) current have an hypoalgesic effect on pattientes suffering from miofascial neck pain, compared with a only dry needling treatment. psicological varaibles were also mesured in order to determine how they change after each treatment.

all patients suffered from mechanical neck pain and were randomized into three groups of treatment. a doible blinded control was carryed out. the main outcome messures were visual analogue scale (vas). the scondary outcome messures were pressure pain hreshold (ppt) and active range of movement (rom). also psicologicla messures were taken, like neck dissability index, level of stress and ansiety, fear pain and pain avoidance strategies.

Eligibility criteria:
inclusion criteria: * mechanical neck pain of at least 6 months. * vas 2 or greather. * existance of miofascial trigger point in trapezius muscle assesed by an expert pt. exclusion criteria: * neck pain due secondary to ostheoporosis, metastasis, neoplasias, fractures, infections, cervical stenosis or infexious procces. * headache secondary to medular compression presenting one o the following signs: abnormal sensitivity, hiperreflexia, clonus, spread weakness, cervical hernia. * neck pain with radiculopathy. * whiplash. * vertebrobasilar syndrome. * dizzyness. * pregnancy. * having received dry needling treatment before.

Keywords: miofascial pain syndrom. trigger point. dry needling. transcotaneous nerve stimuilation. hipoalgesia
a study of the safety, efficacy and tolerability of nexvax-2 in patients with celiac disease (ced)

Conditions: Celiac Disease; Celiac; Intestinal Disease; Malabsorption Syndromes; Gastrointestinal Disease; Digestive System Disease; Gluten Sensitivity; Autoimmune Diseases

Summary: a randomized, double-blind, placebo-controlled clinical study in human leukocyte antigen (hla)-dq 2.5+ adults with celiac disease (ced).

a phase 2, randomized, double-blind, placebo-controlled clinical study of nexvax2, in adults subjects with confirmed ced who have been following a gluten free diet for at least 12 consecutive months prior to screening. this study will evaluate efficacy of nexvax2 administered subcutaneously. the study plan consists of 3 periods: a screening period of 6 weeks, an approximately 16 week treatment period, and a 4 week post-treatment observational follow-up.

Eligibility criteria:
inclusion criteria: * adults 18 to 70 years of age (inclusive) * history of medically diagnosed celiac disease (ced) that included duodenal biopsy * maintenance of gluten free diet (gfd) for at least 12 consecutive months prior to screening. * willingness to consume a moderate amount of gluten * able to read and understand english * worsening of gi symptoms in response to an oral gluten challenge * hla dq 2.5 positive exclusion criteria: * unwilling or unable to perform self-injections * history of inflammatory bowel disease and/or microscopic colitis. * any medical condition or lab abnormality that in the opinion of the investigator may interfere with study conduct or would impact the immune response (other than ced), confound interpretation of study results, or pose an increased risk to the subject. * use of immunomodulatory or immune-suppressing medical treatment during the 6 months prior to screening * use of oral or parenteral immunomodulatory corticosteroids, within the 6 weeks prior to screening. topical or inhaled corticosteroids are acceptable. * receipt of any investigational drug or participation in another clinical study within 6 months prior to screening. * females who are lactating or pregnant * receipt of any vaccine within 1 week prior to planned first day of the treatment period.
comparing the effectiveness of individual vs. household treatment for scabies in lambaréné, gabon

Conditions: Scabies; Households

Summary: it is unclear whether individual treatment of scabies is similarly effective compared to household treatment. this study therefore compares these two treatment strategies with topical benzyl benzoate for treating scabies in lambaréné and surroundings in gabon. subjects presenting with uncomplicated scabies are randomized into either the individual treatment group, where only the affected subjects receive treatment, or the household treatment group, where all family members are treated in parallel to the affected subjects regardless of signs and symptoms. the primary endpoint is clinical cure after 28 days; the secondary endpoint is the proportion of affected household members per household after 28 days.


Eligibility criteria:
inclusion criteria: * diagnosed with active, uncomplicated scabies * no known hypersensitivity or allergy against benzyl benzoate exclusion criteria: * hypersensitivity or allergy against benzyl benzoate * severe superinfection of scabies lesions