Kornimate/medical-research-clean huggingface dataset:
ppp-botnia exercise intervention study

Conditions: Family History of Type 2 Diabetes

Summary: the aim of the study is to evaluate the long-term effects of a prescription of exercise versus a group-based training program on aerobic fitness, muscle strength and metabolic variables in subjects with poor physical fitness. the participants are further stratified for a family-history of type 2 diabetes. the number of subjects in each group of intervention is planned to be 150, aged 30-70 years and non-diabetic. intervention: all study subjects take part in two individual sessions for exercise prescription aiming at moderate exercise of 30 minutes at least 5 days a week. the prescription group perform exercise by themselves, while the training group will be offered supervised physical training, including both endurance training and training in gym twice a week during 12 months. the subjects will be followed up at 1, 2, 3 and 5 years after the basal visit. methods of follow-up: at the study visits physical fitness will be measured by a 2 km walking test, glucose tolerance by oral glucose tolerance test with measurement of glucose and insulin. lipids will be measured. questionnaires will be used to follow lifestyle, physical activity, cardiovascular disease and medication. in the training group 30 subjects with and 30 subjects without a family history of type 2 diabetes will participate in a sub-study including muscle- and fat-biopsy before the start of the study, after 1 and 5 years.


Eligibility criteria:
inclusion criteria: * poor physical fitness based on repeated walking test (ukk 2 km walking test) * non-diabetic exclusion criteria: * health problems complicating moderate physical training

Keywords: physical fitness family history of type 2 diabetes prescription of exercise
cross-cultural adaptation, validity and reliability of the turkish version of the adap shoulder scale

Conditions: Questionnaire; Shoulder Pain; Validity; Reliability

Summary: shoulder pain is a common musculoskeletal problem that increases disability and decreases quality of life in addition to socio-economic impact. chronic pain is defined as pain lasting longer than three months. chronic pain is a multidimensional and complex experience. according to this model, chronic pain is a multidimensional and complex experience. this experience may be accompanied by different pain beliefs, pain avoidance behaviours, pain-related fear of movement, anxiety and depression. many conditions involving the shoulder complex including traumatic and non-traumatic pain, subacromial impingement, postoperative pain, rotator sheath tears, rotator sheath tendinopathy, shoulder arthritis, adhesive capsulitis, shoulder instabilities may lead to pain-related fear of movement. until now, pain-related fear and avoidance behaviours in patients with shoulder pain have been evaluated with the tampa kinesiophobia scale, pain avoidance beliefs scale and fear of pain scale. however, only patients with low back pain were included in the development of these scales. there was no scale developed specifically for shoulder pain. to fill this gap in the literature, ansanello et al. developed the "avoidance daily activities photo scale for patients with shoulder pain (adap)" scale to evaluate pain avoidance behaviours in individuals with shoulder pain. cross-cultural adaptation, validity and reliability of the turkish version of the adap scale has not been studied. the aim of our study was to perform cross-cultural adaptation, validity and reliability of the turkish version of the avoidance of daily activities photo scale for patients with shoulder pain (adap shoulder scale).

the research will be conducted at hacettepe university faculty of physical therapy and rehabilitation, athlete health unit. the research will be conducted according to the consensus-based standards for the selection of health measurement instruments (cosmin) guidelines. translation and cross-cultural adaptation of the adap shoulder scale will be carried out in five stages according to standard guidelines for scale translation and cross-cultural adaptation.it was planned to include 150 individuals with shoulder pain between the ages of 18 to 64 in the study. the data collection for this planned study will be solely through surveys. the design of the study is a cross-sectional study aimed at developing and assessing the validity and reliability." surveys specific to the research will be implemented in the study.

Eligibility criteria:
inclusion criteria: patients with shoulder pain who have had pain for at least three months the ages between of 18 and 64. exclusion criteria: rheumatological, neurological or musculoskeletal diseases, non-invasive interventions performed in the last 3 months, active infections, history of cancer, conditions requiring post-traumatic surgery.

Keywords: questionnaire shoulder pain validity reliability cross-cultural adaptation
a pragmatic trial of the effect of a mailed patient flyer about prostate specific antigen (psa) testing prior to an annual exam

Conditions: Prostate Cancer Screening

Summary: 1. does a one-page american college of physicians educational flyer about the pros and cons of prostate cancer screening sent to men within two weeks of their scheduled annual health examinations in a general medicine clinic result in a different rate of prostate cancer screening than among men who were not sent the flyer? 2. do patients find the flyer useful and understandable? context: the use of prostate specific antigen (psa) screening for prostate cancer is controversial because of a lack of evidence that such screening saves lives when applied within a population and because such testing can lead to invasive downstream biopsies and aggressive treatment that is associated with a high risk of permanent side effects (e.g. impotence, incontinence). almost all professional societies (american cancer society, american urologic association, american college of physicians, united states preventive services task force) advocate that patients receive education and complete an informed decision-making discussion with their medical providers about the pros and cons of the psa test, as well as their personal preferences, before proceeding with this test. unfortunately, despite these recommendations, there is seldom sufficient time during clinic visits to achieve this goal.


Eligibility criteria:
inclusion criteria: * men age 50-74 who were cared for in a general internal medicine clinic * had scheduled an annual health exam * had not had a psa test within the previous year exclusion criteria: * active cancer diagnosis * history of prostate cancer * need for psa surveillance

Keywords: prostate cancer screening pragmatic trial health literacy
armenian nationwide registry of systemic autoimmune and autoinflammatory diseases

Conditions: Behcet Disease; Antineutrophil Cytoplasmic Antibody (ANCA) Positive Vasculitis; Takayasu Arteritis; Giant Cell Arteritis; Sjogren's Syndrome; Rheumatoid Arthritis; Hereditary and Acquired Angioedema; Primary Antiphospholipid Syndrome; Celiac Disease

Summary: longitudinal prospective multicenter armenian registry of systemic autoimmune, autoinflammatory diseases with constitution of bio-banking.

autoimmune and auto inflammatory diseases are a growing group of disorders caused by a dysregulation of the innate immune system leading to episodes of systemic inflammation. they represent a group of diseases characterized by excessive autoimmune or inflammatory reaction leading to various organ damage and drop in patient's quality of life, usually underlined by particular genetic factors and environmental triggers. the progress of these diseases is often evaluated in the form of activity scores. a number of scores are available to predict the evolution of autoimmune autoinflammatory diseases. for a long time, these pathologies have remained slightly explored because of their complex physiopathology and the absence of specific therapies. in the last few years, significant progress has been made in terms of both pathophysiology and treatment. treatment with biological targeted therapies transformed the prognosis and survival of the patients, improved their quality of life and underlined the necessity of a global management of these patients. in armenia, the epidemiological elements of these pathologies are not known, nor are the circumstances of their discovery. the initial biological manifestations and the management of these patients are variable from one center to another, whether in terms of supportive or specific therapeutic elements.

Eligibility criteria:
inclusion criteria: 1. patients with a confirmed diagnosis of at least one of following autoimmune systemic diseases: behcet disease, anca -positive vasculitis, takayasu arteritis, giant cell arteritis, systemic sclerosis, sjogren syndrome, rheumatoid arthritis, spondylarthritis (psoriatic, ankylosing, crohn's related), angioedema hereditary and acquired, pediatric dermatology, autoinflammatory diseases (hereditary and acquired), unexplained infertility, immune thrombocytopenic purpura/ autoimmune hemolytic anemia (itp, aha), primary anti-phospholipid syndrome (aps), celiac disease. 2. age: major and minor 3. patients who have been informed and provided with written informed consent to participate or consent from legal representative exclusion criteria: 1. patients refusing to participate in the registry 2. non-consent from legal representative 3. breastfeeding or pregnant patients

Keywords: arthritis autoimmune systemic autoinflammatory behcet takayasu giant cell angioedema aps
study of metabolic and haemodynamic effects of metformin and glimepiride in patients with type 2 diabetes mellitus

Conditions: Type 2 Diabetes

Summary: aim: the purpose of this study is to compare the effects of glimepiride(g) and metformin(m) on vascular reactivity, haemostatic factors and glucose and lipid profile in patients with type 2 diabetes. methods: a prospective study will be performed in 20 uncontrolled patients previously treated with dietary intervention. participants will randomized into m (750 to 2500 mg/day) or g (1 to 8 mg/day) therapy. after 4 months, the patients will be crossed-over with no washout period to the alternative treatment for an additional 4-month period on similar dosage schedule. * the following variables were assessed before (basal values) and after 4 months of each treatment period: 1. hormonal and metabolic determinations: fasting plasma glucose, insulin, catecholamine, lipid profile and hba1 levels. 2. haemostatic factors: t-pa antigen and activity, pai-1 antigen and activity, platelet aggregation, fibrinogen and plasminogen levels. 3. cardiovascular evaluation: flow indexes of carotid and brachial arteries. also, at the end of each treatment period, a 12-hour metabolic profile including measurements of glucose, insulin, glucagon, proinsulin and triglycerides levels at fasting and every 2 hours (7:00 am to 7:00 pm)will be done

measurements were be made at fasting

Eligibility criteria:
inclusion criteria: * type 2 diabetes patients with fasting glucose values \>7.78 mmol/l and/or glycated hemoglobin exceeding 1.0% or more the normal range (4-8.5%) after 2 or more months of a diet therapy exclusion criteria: * any severe concomitant illness * nephropathy (serum creatinine \>1.6 mg/dl and microalbuminuria) * uncontrolled hypertension (bp \>190x120 mmhg) * stroke * peripheral vascular disease * marked dyslipidemia (total cholesterol\>6.5mm/l and triglycerides levels \>2.8mm/l) * coagulopathy * proliferative retinopathy and use of hypolipemic and anticoagulant medications or autonomic neuropathy * assessed by blood pressure response to standing * beat-to -beat heart rate variation * valsalva maneuver and handgrip test.

Keywords: type 2 diabetes metformin glimepiride glucose control vascular reactivity adverse reaction to other drugs and medicines
treatment exercises with core stability and dynamic resistance exercise for postmenopausal women with osteoporosis

Conditions: Postmenopausal Osteoporosis

Summary: osteoporosis is a common disease that affect most of postmenopausal women. various treatment procedures are used to avoid future complain among postmenopausal population.

ethics statement this study was approved by the institutional review board of the faculty of physical therapy, cairo university, egypt (no.p.t. rec/012/003867) and strictly adhered to the criteria proclaimed in the latest version of the declaration of helsinki code of ethics. each woman freely consents to participate in this research study. study design. a prospective double-masked randomized controlled trial. sample size calculation. based on a pilot study, sample size was calculated according to the significant difference in the value of mean difference (pretreatments - posttreatment values) of odi between control (16.60 ± 2.22) and study (26.50 ± 4.09) groups in two tailed unpaired t test, with α=0.05, power of 80%, and an effect size of 0.74. so, a sample size of 30 patients/per group would be required and increased to 35 women to allow for a 15% dropout rate (power 301 http: www.psycho.uni-duesseldorf.de) randomization. randomization of sample selection were achieved using closed envelop way to allocate study participants to either intervention group (medication and treatment exercises) control group (medication only). all postmenopausal women and examiners were unaware of group allocation.

Eligibility criteria:
inclusion criteria: * their ages were ranged from 50-60 years. * their bmi not exceeded 30 kg/m2. * all postmenopausal women past of at least one year after menopause. * had no regular physical activities during the past 6 months. exclusion criteria: * patients didn't take any drug before the study (e.g. calcium tablets, multivitamins containing calcium and vitamin d) that affects bone metabolism. * patients that were smoking or having alcohol consumption. * histories of fracture and surgery, or severe injuries

Keywords: postmenopausal osteoporosis corestability dynamic resistance bone mineral density
clinical outcomes from nalmefene

Conditions: Opioid Overdose

Summary: the purpose of this study is to assess the effectiveness of nalmefene relative to naloxone for the reversal of opioid intoxication in emergency department (ed) settings.


Eligibility criteria:
inclusion criteria: 1. presumed or known opioid overdose in community settings. 2. experiencing clinically significant respiratory depression based on appropriate medical judgement. 3. patient airway is open and unobstructed at the time of enrollment. (utilization of oral pharyngeal or nasal pharyngeal airway is allowed.) 4. pre-hospital naloxone administration is allowed. exclusion criteria: 1. patient age known or estimated to be less than 18 years. 2. patient has one or more additional documented acute medical, traumatic, toxicologic, or psychiatric conditions that would extend length of treatment or adversely alter the clinical outcome. 3. cardiac arrest, secondary to opioid intoxication. 4. arrested, jailed, or imprisoned patients. 5. inappropriate for the study per judgement of research team.
assessment of retinal nerve fibre layer by optical coherence tomography in uveitis patients with papilloedema

Conditions: Uveitis; Glaucoma

Summary: assessment of optic disc morphology can be difficult in patients with uveitis and papilloedema. therefore different optical coherence tomography (oct) and laser scanning techniques may help to detect damage to the retinal nerve fibre layer.


Eligibility criteria:
inclusion criteria: * anterior or intermediate uveitis * papilloedema * glaucoma exclusion criteria: * dense cataract * dense vitreous opacification * circular posterior synechiae

Keywords: anterior and intermediate uveitis papilloedema
study to evaluate solesta for treatment of fecal incontinence

Conditions: Fecal Incontinence

Summary: the study will evaluate the safety and efficacy of solesta as an injectable bulking agent in the treatment of fecal incontinence for a total of 24 months after completed treatment.


Eligibility criteria:
inclusion criteria: * 18-80 years of age, male or female * screening fecal incontinence severity score (ccfis) * fecal incontinence episodes over a 28-day period * failed conservative treatment for fecal incontinence exclusion criteria: * complete external sphincter disruption * significant anorectal disease * anorectal surgery within the last 12 months prior to the study * active inflammatory bowel disease * immunodeficiency or receiving immunosuppressive therapy * malignancies in remission for less than 1 years prior to the study * bleeding disorders or receiving anticoagulant therapy * chemotherapy within the last 6 months prior to the study * prior pelvic radiotherapy * pregnant or breast-feeding women, or women of childbearing potential not practicing adequate contraception or planning to stop such contraception within the first year of the study * women within 6 months post partum * participation in any other clinical study within 3 month prior to the study * other severe conditions or in other ways unsuitable to participate according to investigator judgement
somesthesia in cancer patients: variability and influence on eating experience

Conditions: Digestive Cancers; Breast Cancer; Gynecologic Cancer; Lung Cancer; Nose Cancer; Throat Cancer; Ear Cancer

Summary: patients with cancer are at high risk of denutrition, in france 39% of these patients suffer of malnutrition. this can affect the immunity, the mental balance and impact the treatment response and the quality of life. cancer treatments cause many side effects related to food intake as well as sensory alteration, important factor contributing to reduced appetite and inadequate food intake to cancer patients. somest'alim2 is a prospective, non-randomized, monocentric, multisite study that aims to evaluate the appreciation of patients with different types of cancer (digestive, gynecological, breast, ear, nose and throat (ent) or lung) of two different food versions (sweet and salty), in standard and enhanced version. patients must be under treatment from at least two months, and before food testing their sensory capacity and quantity and the quality of their saliva will be tested. they will also be asked to answer to different questionnaires: socio-demographics, appreciation of food samples, self-assessment of oral symptoms and sensory perceptions, md, quality of life questionnaire (qlq-c30) and food quality of life questionnaire. in a context of sensory alterations patients should appreciate more the enhanced food versions. patients perception of food will be evaluated using a visual analogue scale and results will be correlated with saliva characteristics, subjective sensory perceptions and oral symptoms.


Eligibility criteria:
inclusion criteria: * patient between 18 and 70 years old * patient with digestive, breast, gynecologic, ent or lung cancer * patient receiving a cancer treatment from at least two months * patient having given his free, informed and express written consent exclusion criteria: * patient having a radiotherapy treatment for an ent cancer * patient with a known food allergy/intolerance to food samples (which may contain dairy products) * patient unable to swallow soft food * patient having presented nausea and vomiting during the last 24 hours * patient with severe inflammation of the mouth or throat (ulcers, mucus) * patient with cognitive disorders and memory loss * pregnant women or breastfeeding * adult under legal protection (guardianship)

Keywords: cancer nutrition somesthesia food perceptions
study of limited versus continuous isoniazid tuberculosis preventive therapy in hiv-infected persons in botswana

Conditions: Tuberculosis; HIV Infections

Summary: this is a randomized, blinded, two-arm comparative trial of continued versus limited isoniazid (inh) tuberculosis (tb) preventive therapy in hiv-infected adults in gaborone and francistown, botswana. subjects will be accrued over two years and followed for a minimum of 36 months.

randomized, double blinded, two-arm comparative trial of continuous vs. limited isoniazid preventive therapy in hiv-infected adults in gaborone and francistown, botswana. subjects will be accrued over two years and followed for a minimum of 36 months.

Eligibility criteria:
inclusion criteria: 1. hiv-infected 2. age \>=18 years 3. tuberculin skin test positive or negative 4. laboratory: * hemoglobin (hgb) \>6.5 gm/dl; * neutrophil count \>1,000 cells/mm3; * platelets \>75,000/mm3; * ast (sgot) \<122 u/l; * creatinine \<1.5 mg/dl; * beta hcg = negative 5. karnofsky performance status \>=60 6. signed informed consent exclusion criteria: 1. history of tb in the last 3 years or current active tb 2. history of noncompliance to chronic therapies

Keywords: tb tuberculosis inh isoniazid preventive therapy hiv aids botswana ltbi latent tb infection
effectiveness of adding zinc to the current case management package of diarrhea in a primary health care setting

Conditions: Diarrhea; Hospitalization

Summary: use of zinc in diarrhea may be an effective intervention to reduce hospitalizations and child mortality as it could reach the most vulnerable children in a community and reduce severity of not only diarrhea but also of associated infections. it might also potentially reduce antibiotic use. we conducted a pilot study prior to conducting a community based controlled effectiveness trial to assess whether addition of zinc as a therapeutic modality for diarrhea delivered through existing channels, reduces visits to health care providers, antibiotic and other drug use, and increases ors use during diarrhea.

the pilot study was conducted in a primary health centre (population \~33000) in faridabad district of the state of haryana in india. formative research identified perceptions of caregivers regarding childhood diarrhea, causation and management, care seeking sources and caregivers expectations from healthcare providers. caregivers in households with children under 5 years old were interviewed in a cross sectional survey to ascertain family characteristics, ors prescription and use rates, drug prescription rates by healthcare providers and other variables of interest. in partnership with the local government, channels for distribution of zinc and ors packets were defined. the channels included physicians (at phc and private practitioners), auxiliary nurse midwives (anms) and anganwadi workers (awws)of the integrated child development services (icds) scheme. recommendations were developed and translated into local vernacular. a poster, which incorporated the recommendations and pictures of zinc strip and ors packets, was designed. these posters were put up at different places in the study area. all channels were trained and provided with the supplies of zinc strips and ors packets except the private practitioners who received only zinc strips and advised caregivers to take ors packets from government channels. effectiveness of this pilot program was assessed through 2 cross sectional surveys, 3 and 6 months post training. the cross sectional surveys revealed that the prescription of syrups, tablets, powders and injections during diarrhea and cost of treatment decreased significantly. prescription and use of ors increased markedly. zinc tablets were prescribed and used in about half the episodes 6 months after start of intervention. it was feasible to train various government and community channels to promote zinc as treatment of acute diarrhea through the primary health care system.

Eligibility criteria:
inclusion criteria: * children aged 1 month to 5 years with diarrhea exclusion criteria: * illness requiring hospitalization (referral)

Keywords: zinc diarrhea hospitalization programme