Kornimate/medical-research-clean huggingface dataset:
evaluation of the novel use of gamification with alternative goal-setting experiences

Conditions: Atherosclerotic Cardiovascular Disease

Summary: to use a randomized controlled trial to test the effectiveness of four goal-setting strategies within a gamification intervention to increase physical activity among adults at elevated risk for ascvd.

atherosclerotic cardiovascular disease (ascvd) is the leading cause of mortality in the united states. while increased physical activity can reduce this risk, less than half of adults in the united states meet the minimum recommendation guidelines for physical activity. gamification, or the application of game design elements to non-game settings, has demonstrated promise in increasing physical activity when designed using insights from behavioral economics. however, the best way to design goal-setting within these interventions has not been well-examined. in this randomized controlled trial, the investigators will evaluate the effectiveness of four different goal-setting strategies within a gamification intervention to increase physical activity among adults with elevated risk for ascvd. the trial will include a 2-week run-in period to estimate a baseline, followed by an 8-week introductory phase, an 8-week maintenance phase, and then after the intervention is completed an 8-week follow-up period.

Eligibility criteria:
inclusion criteria: * age 18 years or older; * ability to read and provide informed consent to participate in the study; * diagnosis of clinical ascvd or a 10-year ascvd risk score ≥ 7.5% calculated according to the 2013 acc/aha guidelines; * smartphone or tablet compatible with application for the wearable activity tracking device. exclusion criteria: * conditions that would make participation infeasible such as inability to provide informed consent, illiteracy or inability to speak, read, and write english; * conditions that would make participation unsafe such as pregnancy or being told by a physician not to exercise; * already enrolled in another study targeting physical activity; * any other medical conditions or reasons he or she is unable to participate in a physical activity study for 24 weeks; * baseline step count of 10,000 steps or greater.

Keywords: physical activity goal-setting gamification
bridging the gap to adult diabetes care

Conditions: Type1diabetes

Summary: adolescents with type 1 diabetes face particular challenges related to having a chronic illness that requires daily intensive self-management and medical follow-up during a period when their social, developmental, educational, and family situations are in flux. when transitioning from pediatric to adult care, over a third of youth have a care gap of \>6 months. during this vulnerable period youth are at risk for acute life-threatening complications such as diabetic ketoacidosis, and for poor glycemic control, which confers an increased risk of chronic diabetes complications. gaps in care may be a result of deficiencies in transition processes causing some young people to be poorly prepared for adult care and dissatisfied with the transition process. ineffective transition can lead to decreased frequency of diabetes visits and an increased risk of adverse events in young adulthood. further, risk factors such as psychiatric comorbidity and behavioural problems in adolescents with type 1 diabetes are associated with poor outcomes in early adulthood. quality improvement initiatives can be designed to optimize care processes such as referral systems to adult diabetes providers. our overall objective is to optimize care and outcomes for youth with diabetes as they transition to adult care. specific aim 1: to improve glycemic control in youth around the time of transition from pediatric to adult diabetes care specific aim 2: to evaluate the fidelity and quality of a quality improvement intervention designed to improve transition care processes and to identify contextual factors associated with variation in outcomes.


Eligibility criteria:
inclusion criteria: * all youth with a clinical diagnosis of type 1 diabetes followed at participating centres at the time of their final pediatric clinic visit between jan 1, 2018 and dec 31, 2020. * participants will be transitioning to adult care (ages \~16-19 yrs). * capacity to read and understand english (we estimate that \>95% of participants will fulfill this requirement). * capacity to consent for themselves. exclusion criteria: * individuals with non-type 1 diabetes. * individuals with type 1 diabetes who move out of ontario within 12 months after their final pediatric visit. * individuals with type 1 diabetes who do not have the capacity to consent for themselves.

Keywords: transition to adult care glycemic control
a study of subcutaneous mircera once monthly in the treatment of anemia in participants with chronic kidney disease not on dialysis

Conditions: Renal Anemia, Chronic

Summary: this study will compare the efficacy and safety of subcutaneous mircera and subcutaneous darbepoetin in the treatment of renal anemia in participants with chronic kidney disease who are not on dialysis and not receiving erythropoiesis-stimulating agents (esa). participants will be randomized to receive either mircera once every 4 weeks, at a starting dose of 1.2 micrograms/kilogram (mcg/kg), or darbepoetin alfa once weekly, at a starting dose of 0.45 mcg/kg (or once every two weeks, 0.75 mcg/kg). the anticipated time on study treatment is 3-12 months.


Eligibility criteria:
inclusion criteria: * participants with chronic kidney disease (ckd) stage 3 (creatinine clearance \[crcl\]/ glomerular filtration rate \[gfr\] 30 to 59 milliliter per minutes per 1.73 meter square \[ml/min/1.73m\^2\]) or stage 4 (crcl/gfr 15-29 ml/min/1.73m\^2) who did not require dialysis. crcl/gfr was estimated with the cockcroft-gault equation or the abbreviated modification of diet in renal disease (mdrd) equation * anemia defined as baseline hb concentration less than (\<) 10.5 gram per deciliter (g/dl) exclusion criteria: * previous therapy with any esa within 12 weeks prior to screening * renal allograft in place * immunosuppressive therapy in the 12 weeks prior to screening * overt gastrointestinal bleeding and red blood cells (rbc) transfusions within 8 weeks before screening
indicated prevention with at-risk gamblers

Conditions: Gambling; Pathological Gambling; Problem Gambling

Summary: the overall purpose of this study is to reduce the prevalence of gambling risk in college students by evaluating the effectiveness of different treatments in reducing gambling behavior and related negative consequences.

participants in this study will be randomly assigned to a personal feedback intervention (pfi) or assessment only for 3 years. the pfi intervention will be delivered in a single session. measures will include the norc dsm screen for problem gambling (nods), the south oaks gambling screen (sogs), gambling quantity and perceived norms, perceived injunctive gambling norms, gambling problems index, gambling frequency, attitudes and beliefs about gambling and self-control, readiness to change, gambling expectancies, gambling motives, gambling risk perception, psychiatric symptoms, assertiveness, coping skills, substance use, alcohol-related problems, self-determination, and social desirability.

Eligibility criteria:
inclusion criteria: * college student * south oaks gambling screen (sogs) score greater than 3 exclusion criteria: * none, other than not meeting inclusion criteria

Keywords: gambling pathological gambling problem gambling college students prevention
the effects of different anesthetics on functional connectivity

Conditions: Sedation

Summary: this research is a prospective cohort study. the aim of the study is to determine different levels of sedative mechanism and the effect on brain functional connectivity of midazolam, dexmedetomidine and propofol.

this research will include 120 healthy volunteers and 120 brain tumor patients; the participants will be allocated into midazolam, dexmedetomidine and propofol group. resting and task fmri will be performed at awake (bis\>90), mild sedation (bis 80-85), moderate sedation (bis 65-75), deep sedation (bis 45-55) and recovery states (bis \>90). the primary outcome of our study is the effect of different levels of sedation for brain network connection. the secondary outcomes are the effect of different levels of sedation for default, executive control, sensory and motor networks and their subnetwork connectivity; the sedation state, circulatory and respiratory parameters of the participants, and the adverse events.

Eligibility criteria:
inclusion criteria: * 1. male, 18 \~ 65 years old * 2. healthy volunteer / brain tumor patients * 3. senior high school and above * 4. sign informed consent exclusion criteria: * 1. in vivo implant mri check taboo * 2. cardiopulmonary liver and kidney and other systemic complications * 3. history of major surgical anesthesia * 4. abuse of drugs, alcoholism history * 5. test drug allergy history * 6. claustrophobia * 7. left hand

Keywords: anesthetics; fmri; functional connectivity
comparison of endoscopic and laparoscopic resection for small gastric gastrointestinal stromal tumor

Conditions: Therapeutic Value of Endoscopic and Laparoscopic Resection for Small Gastric Gastrointestinal Stromal Tumor

Summary: comparison of endoscopic and laparoscopic resection for small gastric gastrointestinal stromal tumor


Eligibility criteria:
inclusion criteria: * 18-70 years old chinese; * definite diagnosis or endoscopic ultrasonography, ct and other highly suspected chinese patients with gastric stromal tumors; * patients voluntarily signed informed consent and have been orally informed of the specific trial plan. exclusion criteria: * patients with gastric stromal tumors with distant metastasis who cannot be treated by laparoscopic surgery; * combined heart , cerebrovascular , liver , kidney , and hematopoietic system serious primary disease; * gastric stromal tumors with severe digestive tract hemorrhage endanger the immediate surgical treatment of life; * the investigator considers that it is not suitable for this test.
sex selection of human spermatozoa

Conditions: Infertility; IVF

Summary: this study aims to demonstrate a reliable method of selecting gender specific sperm. x-bearing spermatozoa and y-bearing spermatozoa will be identified from the density gradient layers. the selected gender specimen will then be utilized for assisted reproductive fertilization- in vitro fertilization or intrauterine insemination which are routine standard of care procedures.

the study aim is to test a simple, reliable, and inexpensive method to attempt selection of gender specific spermatozoa. couples will undergo evaluation and treatment according to the standard clinic procedures. sperm samples provided for infertility treatment will be further analyzed routine semen analysis for volume, concentration, mobility and morphology. sperm samples will be provided by consenting males undergoing infertility treatment. a multilayer density gradient will be performed utilizing an fda approved solution, enhance-s plus cell isolation media (vitrolife, san diego, ca). this density gradient is also used for standard semen preparation for intrauterine insemination. x-bearing spermatozoa and y-bearing spermatozoa will be identified from the density gradient fractions. sperm suspensions will be smeared on slides for fish analysis using centromeric probes for chromosomes 18, x, and y. the ratio of x- to y- chromosome bearing spermatozoa will be assessed as a percentage on at least 200 cells per slide. aneuploid cells and those without signals will be omitted. unselected fractions of each sample will serve as controls. the rate of x-bearing spermatozoa after 4-layer density gradient will be calculated. after thorough counseling, the selected preconception gender specimen will then be utilized for assisted reproductive fertilization- in vitro fertilization with or without intracytoplasmic sperm injection (icsi) or intra uterine insemination which are routine standard of care procedures.

Eligibility criteria:
inclusion criteria: * couples undergoing infertility treatment with ivf or insemination seeking gender specific offspring for medical and non medical reasons exclusion criteria: * severe male factor
essential oils and post covid-19 fatigue

Conditions: Covid19; Fatigue

Summary: the purpose of this study is to assess the efficacy of plant based aromas on energy levels among otherwise healthy female survivors of covid-19.

after being informed about the study, participants will provide informed consent, then will be randomized into one of two groups in a 1:1 ratio. participants will either inhale an inert blend twice a day or an active aroma twice a day for 14 days.

Eligibility criteria:
inclusion criteria: * age 19-49 * lives in the united states * otherwise healthy * covid-19 diagnosis between december 1, 2020 and march 31, 2021 * decreased energy or fatigue at a level that was not present prior to the diagnosis exclusion criteria: * positive covid-19 test any time before december 1, 2020 * positive covid-19 test any time after march 31, 2021 * covid vaccine of any type scheduled during the intervention period or the week prior to the start of the study * allergy to any of the ingredients * pregnant, trying to conceive, or breastfeeding * regular smokers in the home * abnormal pulmonary function * chest pain * recurring headaches * uncontrolled hypertension * chronic fatigue syndrome diagnosis * persistent fatigue prior to covid-19 diagnosis * hypothyroidism

Keywords: essential oils aromatherapy energy
the effects of video based cervical and thoracal posture exercises on office workers

Conditions: Physical Inactivity; Quality of Life

Summary: aim of this study was investigate the effects of video-based cervical and thoracic postural exercises on muscle strength and endurance, hand grip strength, head-neck posture, quality of life and patient satisfaction in office workers.

60 office workers between the ages of 25-65 were included in the study. participants were randomly divided into exercise group (eg, n=30) and control group (kg, n=30). the video-based postural exercises were uploaded to the computers of the eg participants. they were asked to perform the exercises simultaneously with the video, 3 days a week for a total of 6 weeks. the control group was given one session of training on postural exercises. cervical and scapular muscle strength and endurance, grip strength, craniovertebral angle, muscle endurance and strength, grip strength and head-neck posture measurements were made before the study and at the end of the 6th week. in addition, quality of life and satisfaction were evaluated with questionnaires.

Eligibility criteria:
inclusion criteria: * to be an office worker for at least 3 years * to be literate exclusion criteria: * history of cervical, thoracic or shoulder surgeries * exercising regularly for the last 6 months

Keywords: exercise posture workers
comparative effects of post-exercise ingestion of a high or low molecular weight solution on resistance exercise performance

Conditions: Task Performance and Analysis

Summary: this study sought to examine differences in resistance exercise performance, as measured by the kinetic and kinematic profile during multiple sets of the back squat exercise, following ingestion of high or low molecular weight carbohydrate beverages.


Eligibility criteria:
inclusion criteria: * having at least 2 years resistance training experience to include the parallel back squat exercise at least once a week * no musculoskeletal injury within previous 1 year * not having consumed any nutritional or ergogenic supplement excluding protein and/or a daily vitamin for the previous 6-week period exclusion criteria: * no previous resistance training experience * musculoskeletal injury within the previous 1 year * having consumed or presenting consuming a nutritional or ergogenic supplement
study evaluating a novel ibuprofen formulation in episodic tension-type headache

Conditions: Pain

Summary: this study will compare the ability of a single-dose of a novel ibuprofen formulation to relieve pain compared to placebo and standard ibuprofen in the treatment of episodic tension-type headache.


Eligibility criteria:
inclusion criteria: * males and females at least 18 years to 65 years of age * a diagnosis of an episodic tension-type headache, as defined by the international headache society * a history of episodic tension-type headache with the following characteristics: 4 headache episodes per month for the last 6 months of moderately severe intensity; headache generally lasts more than 3 hours if left untreated; adequate headache relief is generally obtained with over-the-counter (otc) doses of otc analgesics exclusion criteria: * pregnancy or breast-feeding * alcohol or substance abuse * any serious medical or psychiatric disorder * history of stomach ulcers, stomach bleed, or other bleeding disorders

Keywords: headache
igf-i/igfbp-3 therapy in children and adolescents with growth hormone insenitivity syndrome (ghis) such as laron syndrome

Conditions: Growth Hormone Insensitivity Syndrome (GHIS); Laron Syndrome

Summary: study objective to evaluate the safety, tolerability, and efficacy, as growth velocity (statural growth), of rhigf-i/rhigfbp-3 administered for 12 months in pre-pubertal children and adolescents with ghis. study design this study is an open-label, multi-center clinical trial to evaluate the safety and effectiveness of rhigf-i/rhigfbp-3 to increase rate of growth when administered once daily for 12 months in children and adolescents with growth hormone insensitivity syndrome (ghis) such as laron syndrome. at the end of the initial twelve-month treatment period, additional safety and long-term efficacy data will be assessed in a second 12 month treatment period.


Eligibility criteria:
inclusion criteria: 1. a diagnosis of ghis such as laron syndrome, 2. 2 - 18 years of age, 3. height less than or equal to -3sd for age, 4. pre-pubertal, defined as tanner breast stage 1 or testis volume \<4ml exclusion criteria: 1. children in puberty, 2. diagnosed malignancy, 3. a diagnosis of diabetes mellitus
comparison of phvp of different vth methods

Conditions: Vault Prolapse, Vaginal

Summary: to evaluate the post-hysterectomy vault prolapse (phvp) rates performed using different methods of vaginal total hysterectomy (vth).

objective: to evaluate the post-hysterectomy vault prolapse (phvp) rates performed using different methods of vaginal total hysterectomy (vth). methods: a computer search identified a total of 251 women who underwent vth with/without concomitant surgeries between january 1986 and december 2001 in a single center. thirty-eight women were excluded due to not only a vaginal approach. of the remaining 213 women, 129 and 84 underwent vth via the tsuzi method with residual uterine ligament ligation (ligations group) and traditional vth (without ligations group), respectively. the χ2 and mann-whitney u tests were applied to compare the data. the cumulative percentages of women without phvp were calculated over time and compared using kaplan-meier curves and log-rank tests. a p value of less than 0.05 was considered statistically significant.

Eligibility criteria:
inclusion criteria: 1. female 2. received vth with or without other combined operations. exclusion criteria: 1. laparoscopic-assisted vaginal hysterectomy (lavh) 2. conversion to an abdominal approach 3. unsatisfactory medical record

Keywords: vault prolapse vaginal total hysterectomy
a study to test 2 doses of the hrv vaccine in healthy infants.

Conditions: Infections, Rotavirus

Summary: the main objectives of this study are: 1) in a subset (n = 20 000), to determine vaccine efficacy against severe rotavirus (rv) gastroenteritis (ge) during the period starting from 2 weeks after dose 2 until one year of age. 2) in all subjects (n = 60 000), to determine the safety of gsk biologicals' hrv vaccine with respect to definite intussusception (is) within 31 days (day 0-day 30) after each hrv vaccine dose.

the study has two groups: group hrv and group placebo. two oral doses administered to healthy infants who are 6-13 weeks of age at the time of dose 1, according to a 0, 1 to 2-month schedule. routine epi vaccinations are given at the discretion of the investigator and according to local national plans of immunisation schedule in each participating country. a minimum 2-week interval was to be observed between hrv vaccine and opv doses. of the total enrolled cohort of 60 000 subjects, 20 000 subjects were followed for efficacy and safety until one year of age while 40 000 subjects were followed for safety only until 30-90 days after the second hrv/placebo dose. a subset (n = approximately 13 000) of the 20 000 subjects are followed for efficacy and safety until 24 months of age. from the 20 000 subjects followed for efficacy and safety, a subset of 100 subjects per country (center specific, except finland) provided two blood sample to evaluate immunogenicity.

Eligibility criteria:
inclusion criteria: * healthy infants 6-13 weeks of age at the time of the first study vaccination whose parent/guardian sign a written informed consent and whose parents/guardians can and will comply with the requirements of the protocol (e.g., completion of the diary cards, return for follow-up visits) exclusion criteria: * use of any investigational or non-registered product (drug or vaccine) other than the study vaccine(s) within 30 days preceding the first dose of study vaccine or placebo, or planned use during the study period * chronic administration (defined as more than 14 days) of immunosuppressants or other immune-modifying drugs since birth. (topical steroids are allowed.) * child is unlikely to remain in the study area for the duration of the study * any confirmed or suspected immunosuppressive or immunodeficient condition, including human immunodeficiency virus (hiv) infection * history of allergic disease or reaction likely to be exacerbated by any component of the vaccine * administration of immunoglobulins and/or blood products since birth or planned administration during the study period * any clinically significant history of chronic gastrointestinal disease including any uncorrected congenital malformation of the gastrointestinal tract or other serious medical condition as determined by the investigator
transvaginal ultrasound cervical length screening in singleton pregnancy with prior spontaneous preterm birth

Conditions: Preterm Birth

Summary: preterm birth (ptb) is the major cause of perinatal morbidity and mortality. worldwide, about 15 million babies are born too soon every year, causing 1.1 million deaths, as well as short- and long-term disability in countless survivors. few prognostic tests are available to predict ptb. a short transvaginal ultrasound cervical length (tvu cl) has been shown to be a good predictor of ptb.different strategies have been adopted for prevention of ptb. the evidence supports the use of vaginal progesterone in singleton pregnancies with short cervix, while cervical cerclage seems to be beneficial only in the subgroup of singleton gestations with both prior spontaneous ptb and tvu cl ≤25mm, and not in singletons without prior ptb, nor in multiple gestations. however, so far there are no level-1 data on the efficacy of tvu cl screening neither in low risk nor in high risk pregnancy thus, the investigators aim to assess the efficacy of a policy of tvu cl screening in singleton pregnancy with prior spontaneous ptb


Eligibility criteria:
inclusion criteria: * 18-50 years of age * singleton gestations * women with prior spontaneous preterm birth, defined as spontaneous preterm delivery 16 0/7 - 36 6/7 weeks exclusion criteria: * multiple gestation * ruptured membranes or fetal structural or chromosomal abnormality at the time of randomization * ballooning of membranes outside the cervix into the vagina at the time of randomization * labor or cerclage in situ at the time of randomization