Kornimate/medical-research-clean huggingface dataset:
pet-ct to assess brain damage in cardiac arrest patients

Conditions: Cardiac Arrest; Brain Injuries

Summary: this was a single-center, observational study. patients with successful cardiopulmonary resuscitation (cpr) will be transferred to the emergency intensive care unit for further standardized management. after successful return of spontaneous circulation (rosc) for 72 hours and hemodynamic stability for 24 hours, the patients underwent positron emission computed tomography (pet-ct) examination after resuscitation. the supervising physician accompanied the patient and used monitors to monitor vital signs during the examination. patients who were on ventilators were mechanically ventilated with a magnetic ventilator (hamilton-mri, united states). in addition to conventional cerebral oxygen metabolism, cerebral blood flow, oxygen extraction fraction, cerebral blood volume and other indicators were added in this experiment. these indicators can evaluate the patient's cerebral metabolism, cerebral blood flow and cerebral blood oxygen damage degree. the neurological outcome was followed up 6 months after onset according to the cerebral performance category（cpc）.


Eligibility criteria:
inclusion criteria: * age ≥18 years. * sustained hemodynamic stability for ≥24h. * the patients were unconscious and not able to obey verbal commands. • advanced life support and target temperature management within 6 hours of return of spontaneous circulation (rosc). exclusion criteria: * patients with hemodynamic instability. * patients who could not complete cranial pet-ct examination for special reasons. • patients during pregnancy. * patients who combined traumatic brain injury, stroke, cerebral hemorrhage and other diseases. * patients whose family members did not agree to be enrolled.

Keywords: cardiac arrest positron emission tomography-computed tomography cerebral metabolism cerebral blood flow cerebral oxygenation
20-valent pneumococcal conjugate vaccine safety and immunogenicity study in healthy japanese infants

Conditions: Pneumococcal Disease

Summary: 20-valent pneumococcal conjugate vaccine safety and immunogenicity study in healthy japanese infants


Eligibility criteria:
inclusion criteria: * japanese male or female infants ≥2 months to ≤6 months at the time of consent. * healthy infants determined by clinical assessment, including medical history and clinical judgment, to be eligible for the study. exclusion criteria: * history of severe adverse reaction associated with a vaccine and/or severe allergic reaction (eg, anaphylaxis) * major known congenital malformation or serious chronic disorder. * history of microbiologically proven invasive disease caused by s pneumoniae. * other acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the participant inappropriate for entry into this study.
the effect of mobile medical used for the standardized management of gestational diabetes

Conditions: GDM; Blood Glucose; Compliance, Patient; Diet Habit

Summary: a multicenter, randomized controlled trial was conducted to investigate whether health education and life style management through wechat group chat was more effective in controlling blood glucose (bg) than standard clinic prenatal care in women with gdm.

most gestational diabetes mellitus (gdm) can be well controlled by health education and life style management, expecting a better pregnancy outcome. but standard clinic prenatal care which consist of clinic visit every two weeks may not give full play to the effects of gdm management. telemedicine shows its potential to fill this gap. a multicenter, randomized controlled trial was designed to investigate whether health education and life style management through wechat group chat was more effective in controlling blood glucose (bg) than standard clinic prenatal care in women with gdm. women with gdm diagnosed by oral glucose tolerance test between 23-30+6 gestational weeks were randomized to a wechat group chat-based blood glucose management group or routine clinic prenatal care. in pumch, investigators also equip cgm for m-health group allowing a more detailed bg information. the primary outcome was change of glycemic qualification rate during follow up period in both groups. the second outcome was pregnancy outcomes. also, a case-control study is designed to compare the glucose control status between rice-richen meal and wheaten-richen meal, and all other macronutrients and micronutrients are all calculated and same between two groups, which may provide more clues for type of carbohydrate recommendation for chinese women with gdm.

Eligibility criteria:
inclusion criteria: * aged between 18 and 45 years. * with singleton pregnancy * diagnosed as gdm by 75g oral glucose tolerance test (ogtt) and insulin treatment is not required assessed by multi-disciplinary consultation. * be able to use smart phone for chatting, read and write basic chinese. * volunteer for research. exclusion criteria: * pregnancies with diagnosed chronic disease * pregnancies with other pregnancy complications except gdm * pregnancies had recent trauma and treatment of glucocorticoids

Keywords: gdm cgm m-health diet modification blood glucose compliance
a study of cyp-001 in combination with corticosteroids in adults with high-risk agvhd

Conditions: Graft Versus Host Disease, Acute

Summary: this study is a prospective randomized placebo-controlled phase 2 study to compare cyp-001 plus corticosteroids (cs) to placebo plus cs in allogeneic hematologic stem cell transplant recipients with hr-agvhd. severity of gvhd will be assessed at screening and throughout the study using mount sinai acute gvhd international consortium (magic) guidelines. eligible subjects will be randomized to receive either cyp-001 iv infusion on days 0 and 4 or placebo on the same days. all subjects will receive ongoing cs therapy as appropriate per institutional guidelines. subjects will have study visits up to day 100 during the primary evaluation period. during the follow-up period, subjects will have study visits up to 24 months.


Eligibility criteria:
inclusion criteria: * undergone allogeneic hematopoietic stem cell transplant (hsct) * clinically diagnosed with acute gvhd requiring systemic therapy with corticosteroids. * hr-agvhd must meet one of the following clinical features within 72 hours prior to randomization: (a) high-risk as per refined minnesota criteria; or (b) one of the following: (i) isolated stage 2 involvement of the lower gi tract; (ii) stage 1 lower gi tract disease with skin involvement * evidence of myeloid engraftment post allogeneic hsct * life expectancy of at least one month exclusion criteria: * received any systemic treatment for agvhd other than corticosteroids +/- calcineurin inhibitors * chronic gvhd or overlap syndrome with both acute and chronic features of gvhd * relapsed primary malignancy since * received more than one allogeneic hsct * clinically significant respiratory, renal or cardiac disease * cholestatic disorders or sinusoidal obstructive syndrome/veno-occlusive disease of the liver * any active uncontrolled infection requiring treatment and likely to impact on the ability of the subject to participate in the trial. * known infection with cmv, ebv, hhv-6, hbv, hcv, hiv or tuberculosis. if the treatment for cmv, ebv, hhv-6, hbv, hcv has commenced the subject is eligible. * known sensitivity to dimethylsulfoxide (dmso) or any other component of cyp-001. * received any investigational treatment agent within 30 days or within 5 half-lives of screening, whichever is greater.
comparative study between fresh and frozen embryo transfer in pcos patients undergoing ivf treatment

Conditions: IVF

Summary: the objective of our study is to compare in vitro fertilization (ivf) outcomes between fresh embryo transfer (et) and frozen-thawed et in women with polycystic ovary syndrome (pcos).

eligible women will be randomized to two groups in a ratio of 1:1 . both the patients and the clinicians will be aware of the allocated arm. the patients (110) will be equally randomized into two groups: group a will undergo a day 3 fresh embryo transfer after ovarian stimulation, luteal phase support will be started just after follicular aspiration. group b will have all of their embryo cryopreserved after ovarian stimulation with no luteal phase support after the aspiration and then undergo a frozen-thawed day 3 embryo transfer. controlled ovarian stimulation will be done using the gonadotropin releasing hormone (gnrh) antagonist protocol then human chorionic gonadotropin( hcg) 5000 iu trigger for final oocyte maturation.

Eligibility criteria:
inclusion criteria: * women diagnosed with pcos according to modified rotterdam criteria which includes menstrual abnormalities combined with either hyperandrogenism (hirsutism diagnosed by modified ferriman-gallwey score or elevated total testosterone level) or polycystic ovaries. * women ages ≥20 and \<40years old. * bmi less than 35. * women who have a history of infertility. * all patients will receive adjuvant drugs for ovulation induction (metformin from preceding cycle, cabergoline 1 tab daily for 8 days and 500 cc colloid solution on day of ovum pick up). exclusion criteria: * history of unilateral oophorectomy. * uterine abnormalities such as a malformed uterus (unicornuate, septate uterus), adenomyosis, submucous myoma or intrauterine adhesion. * severe male factor for infertility such as azoospermia. * history of repeated icsi trials failure. * women who are unable to comply with the study procedures.

Keywords: ivf-fresh et-fet-clinical pregnancy
sex hormones and inflammatory biomarkers in patients with sickle cell disease

Conditions: Sickle Cell Disease; Vaso-occlusive Crisis

Summary: this study aims to characterize sex differences in the pathophysiology of vaso-occlusive crises (voc) occurring among individuals with sickle cell disease (scd). * the study will compare crp and other biomarkers between females with scd in the follicular phase of the menstrual cycle and males with scd. * the study will explore potential sex differences in biomarker changes between females and males with scd during and following resolution of voc. * the study will compare neutrophil and platelet adhesion to the endothelium and real time fibrin deposition in the blood.


Eligibility criteria:
inclusion criteria: * adult males and females aged 18-45 * diagnosis of sickle cell disease * current hospitalization for vaso-occlusive pain episode or current outpatient infusion at the recruiting sites * able to read and understand english * willing to comply with study procedures exclusion criteria: * currently pregnant, pregnant within the last month, or seeking to become pregnant
family-centered songwriting in pediatric palliative care

Conditions: Cognitive Impairment

Summary: this study evaluates the feasibility and efficacy of a family-centered songwriting intervention for cognitively-impaired children referred to a palliative care service.

music-based interventions have previously been shown to reduce psychological distress in children with life-threatening conditions. however, children with cognitive impairment are frequently excluded from these studies. our study will evaluate the efficacy a family-centered songwriting intervention for the following outcomes: child psychological and physical symptoms, parent psychological distress, and family environment. following recruitment, parent-child dyads will undergo 4 sessions with a licensed music therapist (anticipated to last 1 hour each). during these sessions, families and their children will select a song and engage in a songwriting process which includes various physiologic sounds from the child (i.e. heart rate, breathing). at the conclusion of these four sessions, a music dvd will be produced and delivered to the family.

Eligibility criteria:
inclusion criteria: * children ages 7-17 years * cognitive impairment (t-score of 40 or below on the promis parent-proxy cognitive function) * receiving palliative/complex care * progressively declining disease * ability to hear. * parents 18 years of age and older * parent without cognitive impairment * parent able to speak/understand english exclusion criteria: - none

Keywords: palliative care pediatrics music therapy
plaster cast versus djo walker in paediatric ankle injuries

Conditions: Ankle Sprain Strain

Summary: present treatment of children with stable ankle and foot injuries very often involves a period in plaster cast(s). in the last decade in adult patients this has been superceded in many instances by the use of a removable foot brace/splint. there are many benefits to this approach including progressive rehabilitation, reduced costs in materials and personnel, improved hygiene and adaptability of fit. the use of such a splint has not been investigated in children and this project aims to assess the value of introducing this as a treatment mode through the analysis of outcomes between traditional cast treatment and the newer removable brace/splint treatment. the outcomes will include patients' preferences, clinical results and relative costings.

the study is a longitudinal cohort study of all eligible ankle injuries per the eligibility criteria presenting to sheffield children's nhs fountain trust. these children and their parents/carers are presented with an information sheet regarding the study and are then invited to enter the study. once consented - by appropriately trained research and/or clinical staff - those recruited are treated in either cast or boot on the basis of block randomisation. patients are followed up per protocol and outcomes completed by patients and clinicians. study information is kept securely for future analysis and write up.

Eligibility criteria:
inclusion criteria: 1. 6-16 years 2. foot size has to be large enough for the smallest available djo walker 3. presentation to the sheffield children's hospital emergency department or fracture clinic (some patients present directly to the fracture clinic if they have been injured elsewhere (eg. on holiday or in competitions) 4. acute injuries (less than 72 hours old) 5. stable ankle injuries. this is all ankle sprains and all stable undisplaced ankle fractures. the key here is that the patient would be able to weightbear in cast/djo walker without detriment to the ankle injury, pain permitting 6. signed consent exclusion criteria: 1. \ 16 2. foot size too small for djo walker 3. any unstable ankle injury 4. any ankle injury that could not be treated weightbearing in cast/aircast boot (pain permitting) 5. patients/carers unwilling to participate in the study
myelin imaging changes in patients with neurosurgical diseases

Conditions: Hydrocephalus in Children; Epilepsy; Craniosynostoses; Traumatic Brain Injury

Summary: investigate myelin alterations in patients with neurosurgical diseases

while a number of advanced imaging techniques, notably magnetization transfer, diffusion tensor and quantitative t1 and t2 imaging (mti, dti, qt1 and qt2, respectively), have been used previously to study white matter in neurosurgical diseases, these methods provide only indirect, non-specific information related to myelin content. for example, these modalities can tell when there is swelling that is affecting the movement of water, which may be indicative of a process that would affect myelin, but they cannot tell us specific information about the amount of myelin surrounding a nerve. the investigators propose using a mri sequence, mcdespot (multicomponent driven equilibrium potential of t1 and t2) that utilizes a computer model that takes t1 and t2 sequences and derives a quantitative value for the myelin content in the myelin sheath. in the present program, the investigators propose adding the mcdespot sequence to the mri scanner in accordance with the mri manufacturer's technical requirements. when this sequence is added, the normal sequences are done first and mcdespot is done last. although the sequences obtained for mcdespot are sequences used in clinical practice, the flip-angles are changed so that they cannot be read like a traditional image. rather, the data have to be post-processed by a computer in order to be able to derive myelin information. mcdespot is a 10 minute sequence that can be added to any mri scanner. it is a obtained from standard t1 and t2 sequences.

Eligibility criteria:
inclusion criteria: 1. patient age range: 0-19 2. patients who have an mri ordered clinically and have one of the following conditions: epilepsy, hydrocephalus, craniosynostosis or mild traumatic brain injury. epilepsy, hydrocephalus and craniosynostosis patients will be both newly diagnosed and chronic. mtbi patients will be acute and chronic and defined as a glascow coma score (gcs) of 13-15. 3. patients or their proxy should be capable of giving informed consent exclusion criteria: 1. unable to tolerate an extra 10 minutes of mri scan
use of beta-blockers and risk of new onset diabetes

Conditions: Hypertension

Summary: this study used an observational, retrospective cohort design to compare the presence and timing of new-onset diabetes (nod) between hypertensive patients initiating therapy with carvedilol immediate-release (ir) and carvedilol controlled-release (cr) vs the following cardioselective beta blockers (bbs): atenolol, metoprolol succinate, and metoprolol tartrate (referred to hereafter as 'other bb'). the aim of the study was to investigate the likelihood of developing nod among hypertensive patients initiating carvedilol therapy vs other bb therapy in a real world setting derived from data contained in a large united states (us) managed care database.


Eligibility criteria:
inclusion criteria: * enrollment in a plan captured in the ims lifelink health plan claims database between july 1, 2000 and december 31, 2007 * aged ≥18 years * at least one pharmacy claim for a beta-blocker of interest (carvedilol immediate-release \[ir\]/controlled-release \[cr\], atenolol, metoprolol succinate, or metoprolol tartrate) * index date was the first chronologically occurring prescription for any beta-blocker during the enrollment period * continuously eligible to receive healthcare services 6 months prior to and 3 months after the index date * at least 1 diagnosis of hypertension (international classification of disease, 9th revision, clinical modification (icd-9-cm): 401.xx-405.xx) during this time frame. exclusion criteria: * diagnosis of diabetes mellitus (icd-9-cm: 250.xx) and/or a prescription for antidiabetic therapy in the 6 months prior to and/or 3 months after the index date

Keywords: new-onset diabetes carvedilol claims analysis beta-blocker diabetes mellitus
optimizing music-based interventions for stroke

Conditions: Stroke

Summary: this study will enroll stroke patients and healthy participants. participants will complete baseline measures followed by a music playing task during fmri and simultaneous measurement of motor response using electromyography (emg) and accelerometry and affective response using electrodermal activity (eda) and self-reports. the music task consists of tapping an mri-compatible midi drum with either: (1) improvisation or maintaining the beat and (2) live or recorded piano accompaniment. the primary objectives are to identify the motor, affective, and neural outcomes of improvisation and live accompaniment in music playing tasks.


Eligibility criteria:
inclusion criteria: for participants with stroke, to be eligible to participate in this study, an individual must meet all the following criteria: * hemiparesis resulting from a stroke (ischemic or hemorrhagic) at least 6 months before the enrollment into the study * age from 18 to 89 years * ability to move the wrist flexor and extensor muscles without help from the healthy side, scoring above 3 on the medical research council (mrc) scale for muscle strength, reflecting active movement against gravity * no more than mild resistance to passive movement in the wrist extensor muscle - as demonstrated by a score \<2 on the ashworth scale (brashear et al.., 2002) * a modified rankin scale (mrs) \< 3 indicating moderate to mild disability and the ability to ambulate independently (bonita \& beaglehole, 1988) * ability to comprehend language and provide informed consent * consenting to participate and willingness to complete mri testing procedures for neurologically normal control (nc) participants, to be eligible to participate in this study, an individual must meet all the following criteria: * be matched for age, gender, and socioeconomic status (education level) to a previously enrolled participant with stroke * age from 18 to 89 years * no history of neurological injury * ability to comprehend language and provide informed consent * consenting to participate and willingness to complete mri testing procedures exclusion criteria: * history of neurological injury other than stroke * moderate to severe depression symptoms indicated by a score \>10 on the patient health questionnaire - 9 (phq-9; koenke et al., 2001; williams et al., 2005) * visual impairment unable to be corrected with glasses/contact lenses sufficient to allow reading comprehension * actively performing or practicing a musical instrument more than 2 hours/week * musical anhedonia indicated by a score \< 65 on the barcelona music reward questionnaire (bmrq; mas-herrero et al., 2013) * amusia as measured by the montreal battery of the evaluation of amusia (mbea; peretz et al., 2003) * not being compatible with mri testing, including having implanted devices, previous exposure to metallic fragments, large tattoos, claustrophobia, and pregnancy

Keywords: stroke healthy music mri
acute comfort and haze profile of fid 114657

Conditions: Dry Eye

Summary: the purpose of this study is to describe the acute comfort and haze profile of fid 114657 in dry eye patients.


Eligibility criteria:
inclusion criteria: * documented diagnosis of dry eye exclusion criteria: * must not have worn contact lenses for 1 week preceding enrollment

Keywords: dry eye artificial tears
a study to compare efficacy and safety of mycamine® and itraconazole for preventing fungal infections

Conditions: Fungemia; Fungal Infections

Summary: the objective of this study is to compare the efficacy and safety between mycamine and itraconazole oral solution in preventing invasive fungal infections on autologous(malignant blood diseases) or allogeneic hematopoietic stem cell transplant patients

dosing of mycamine or itraconazole will start at the beginning of the transplant conditioning regimen or within 48 hours after the transplant conditioning regimen, and administration time should be no longer than 42 days

Eligibility criteria:
inclusion criteria: * patients at risk of systemic fungal infections due to their immunocompromised state due to one of the following: * patient with a hematologic malignancy undergoing an autologous hematopoietic stem cell transplant * any patient undergoing an allogeneic hematopoietic stem cell transplant exclusion criteria: * patients with moderate or severe liver disease, as defined by: * ast or alt greater than 5 times upper limit of normal (uln), or; * total bilirubin greater than 2.5 times uln * patients with evidence of a deeply invasive or disseminated fungal infection at time of enrollment

Keywords: antifungal micafungin itraconazole