Kornimate/medical-research-clean huggingface dataset:
correlation of clinical types and complexity of coronary artery disease with patients' metabolic profile

Conditions: Coronary Artery Disease

Summary: the purpose of the research project is to investigate the potential association of the complexity and the severity of coronary artery disease (as assessed via syntax score) with patients' metabolic profile. the aim of the study is to combine biochemical, clinical and laboratory data in order to create an algorithm that will enable an individualized therapeutic patient approach.

the objective of this observational study is to expand our knowledge on the biochemical process and pathogenesis of atherogenesis and to recognize clinically important metabolic biomarkers correlated with the severity and clinical presentation of coronary artery disease (cad). 1050 patients who will undergo coronary angiography will be enrolled in the study. syntax score will be calculated for all participants and their blood samples will be collected before coronary angiography. metabolomics-based analysis will be performed in order to confirm cad prognostic biomarkers previously reported in the literature and to investigate their correlations with cad clinical data. the ultimate aim of this study is to predict the risk of cardiovascular events by incorporating metabolomic information into the syntax score and provide personalized therapeutic guidance to patients.

Eligibility criteria:
inclusion criteria: 1. patients giving voluntary written consent to participate in the study 2. adults 3. patients without previous history of coronary artery disease 4. patients who are admitted in the department of cardiology in the ahepa university general hospital of thessaloniki and undergo coronary angiography for clinical purposes exclusion criteria: 1. cardiac arrest at admission 2. patients with serious concurrent disease and life expectancy of \< 1 year

Keywords: coronary artery disease metabolomics
using videos to improve understanding of the delivery of end-of-life medical care in non-hospital settings

Conditions: Elderly

Summary: to compare the decision making of elderly subjects having a verbal advance care planning discussion compared to subjects using a video.

a.1. aim 1: to recruit 101 subjects over the age of 64 who are newly admitted to a nursing home facility and randomly assign these subjects to one of two advance care planning (acp) modalities: 1. a video visually depicting the goals of care (life prolonging care, limited care, and comfort care) (intervention) or 2. a verbal narrative describing the goals of care (control) encountered if the subject becomes very ill. hypothesis 1: it is feasible to recruit and randomize newly admitted elderly subjects to each of the acp modalities. a.2. aim 2: to compare the care preferences for their primary goal of care (i.e., life-prolonging care, limited care, or comfort care) among 101 subjects randomized to video vs. verbal narrative intervention for acp. hypothesis 2: subjects randomized to the video intervention will be significantly more likely to opt for comfort care (vs. life-prolonging or limited care) as the primary goal of care compared to those randomized to the verbal narrative. a.3. aim 3: to compare knowledge assessment of the goals of care of 101 subjects randomized to video vs. verbal narrative intervention for acp. hypothesis 3: when compared to subjects randomized to the verbal narrative arm, subjects in the video group will have higher knowledge assessment scores when asked questions regarding their understanding of the goals of care.

Eligibility criteria:
inclusion criteria: * over age of 64 * have decision making capacity exclusion criteria: * do not speak english

Keywords: nursing home advance care planning
user performance evaluation of an investigational blood glucose monitoring system

Conditions: Diabetes

Summary: the purpose of this study is to demonstrate that untrained subjects with diabetes can use an investigational blood glucose monitoring system (bgms) with capillary blood obtained from fingerstick and from alternative site (ast) palm .


Eligibility criteria:
inclusion criteria: * males and females, 18 years of age and above * diagnosed as having type 1 or type 2 diabetes * currently self-testing blood glucose at home * able to speak, read, and understand english * willing to complete all study procedures exclusion criteria: * blood borne infections like hepatitis or hiv or infections such as tuberculosis * hemophilia or any other bleeding disorder * employee of competitive medical device company,immediate family member of such, or living within the household of such * pregnancy
bms-188667 in children and adolescents with juvenile rheumatoid arthritis

Conditions: Juvenile Rheumatoid Arthritis

Summary: the primary purpose of the clinical research study is to assess the safety of treating children and juvenile subjects with bms-188667 (abatacept). in addition, the study will assess the effectiveness of bms-188667 in reducing disease activity of juvenile rheumatoid arthritis (jra) or juvenile idiopathic arthritis (jia) as measured by the time to occurrence of disease flare.


Eligibility criteria:
inclusion criteria: * diagnosis of juvenile rheumatoid arthritis or juvenile idiopathic arthritis; * current active arthritis; * failed treatment with at least one disease modifying anti-rheumatic drug (dmard); * subjects must discontinue use of any dmard other than methotrexate prior to the first dose of study medication exclusion criteria: * presence of infection or history of frequent acute or chronic infections; * joint replacement surgery required during the study or history of surgery on more than 5 joints; * live vaccines within 3 months of the first dose of study medication; * unresolved serious bacterial infection or chronic bacterial infection; * subjects who currently have intermittent fever due to jra/jia, rheumatoid rash, hepato-splenomegaly, pleuritis, pericarditis, or macrophage activation syndrome.

Keywords: juvenile idiopathic arthritis
a prospective study to evaluate the specificity of the cobas taqscreen mpx test for use on the cobas s 201 system for screening plasma pools from source plasma donors for the presence of hbv dna, hcv rna, and hiv-1 rna

Conditions: Healthy Volunteer

Summary: this study will evaluate the specificity of the cobas taqscreen mpx test for the simultaneous detection of hbv dna, hcv rna and hiv-1 group m in a minimum of 100,000 individual donor samples in 96-unit pools.


Eligibility criteria:
inclusion criteria: * healthy adults 18-65 years of age * fulfil criteria for plasma donation exclusion criteria: * do not fulfil criteria for plasma donation
acute renal failure in the surgical intense care units - ntuh-sicu-arf (nsarf) study

Conditions: Acute Renal Failure; Sepsis; Postoperative

Summary: we examine the prognosis and etiology of postoperative acute renal failure

postoperative acute renal failure is a serious complication resulting in a prolonged stay and high mortality. acute renal failure (arf) develops in 5 to 30% of patients who undergo surgery, and for all causes, it is associated with mortality rates of 60-90%. despite advances in supportive care and innovations in renal replacement therapies over the past three decades, the mortality rate for these patients remains high. in the previous analysis of nsarf (national taiwan university hospital-surgical intense care unit- acute renal failure database), the mortality rate of acute renal failure patients in sicu is 66.4%, dialysis dependent rate after arf is 5% and renal recovery rate is 28.6%. therefore, the issue concerned is to increase the survival rate and renal recovery rate after acute renal failure. perioperative ischemic reperfusion injury may result in acute renal failure (arf), from which patients can invariably recover. however, there remains a large number of patients whose kidneys fail to recover from arf, and therefore long-term dialysis is required. the dys-regulation of the inflammatory response in critically ill patients has been implicated as an important mechanism underlying the development of multiple organ system dysfunction, septic shock, and death. furthermore, an increase in oxidative stress is considered an important pathogenic mechanism in the development of ischemic and toxic renal tubular injury. we hypothesize that extensive immune dys-regulation and increased oxidative stress might be an important factor leading to arf, and/or associated with their all-cause mortality in critically ill patients. in this study, we will find out (1) first year, the relationship between cytokine storm and free radical storm with urine output during post-surgical arf, and the effect of renal replacement therapy on serum cytokines and free radical level (2) 2nd year, the difference outcome between low low-efficient daily dialysis (sledd), and low low-efficient daily dialysis-hemofiltration (sledd-f), the pharmacokinetics of the sledd (3) the 3rd year, we sill established the disease severity score of post-operative arf patients. (nsarf score) and focus on long-term outcomes for survivors of postoperative arf. from diagnosis to prognosis, we will incorporate important markers of disease diagnosis, treatment and long term outcome. finally, we hope to improve the mortality and the life quality of postoperative arf.

Eligibility criteria:
inclusion criteria: * postoperative acute renal failure exclusion criteria: * patients with ecmo or iabp

Keywords: arf, dialysis, cytokine, free radical, major operations
simultaneous therapy with intravitreal dexamethasone implant and bevacizumab for the treatment of macular edema

Conditions: Macular Edema

Summary: retrospective cases series is a non-randomized, open-label, single-center investigation (retina clinic, são paulo, brazil) of patients diagnosed with macular edema secondary to diabetic retinopathy (dme) and retinal vein occlusions who underwent to simultaneous treatment with intravitreal injection of bevacizumab 1.25mg and implant of dexamethasone 0.7mg.

this retrospective cases series is a non-randomized, open-label, single-center investigation (retina clinic, são paulo, brazil) approved by the institutional review board of hospital oftalmológico de sorocaba/sp, and adhered to the tenets of the declaration of helsinki. were included patients older than 18 years, treated between april 2014 and july 2015, diagnosed with macular edema secondary to diabetic retinopathy (dme) and retinal vein occlusions who underwent to simultaneous treatment with intravitreal injection of bevacizumab 1.25mg (avastin; genentech, south san francisco, ca) and intravitreal implant of dexamethasone 0.7mg (ozurdex; allergan, inc, irvine, ca).

Eligibility criteria:
inclusion criteria: * central macular thickness \> 300 µm on optical coherence tomography (oct) * macular edema secondary to diabetic retinopathy (dme) and retinal vein occlusions exclusion criteria: * intravitreal anti-vegf within 6 weeks * treatment with laser or intravitreal corticosteroids within 3 months of study entry.
educational intervention for better nutrition to preserve functionality - design of a randomised clinical trial

Conditions: Malnutrition

Summary: this project explores whether access to a digital education video can improve the nutritional situation of home-living older adults after being discharged from the hospital.


Eligibility criteria:
inclusion criteria: * surgical patients embedded in a regional hospital. * home-living in one of nine selected municipalities. * be able to read and understand norwegian. * have a consent competence. * have a body mass index \< 24. * have access to a digital solution such as a tablet or phone. exclusion criteria: * persons given only a liquid diet. * persons in a terminally ill phase.

Keywords: older adults diseases-related malnutrition educational video
inhaled corticosteroids on airway smooth muscle in asthma

Conditions: Asthma

Summary: the main objective is to evaluate how treatment with inhaled corticosteroids (ics) affects the characteristics of airway smooth muscle (asm) cells from asthmatic subjects. our hypothesis is that airway smooth muscle cell dysfunction plays an important role in the pathogenesis of asthma, and that treatment with inhaled corticosteroids reverses the abnormalities in airway smooth muscle cell function.

aims and objectives most of the work published to date on the effect of steroids on asm has been carried out in animal models or in in vitro experiments. we would like to evaluate in vivo whether abnormalities in asm function respond to ics. because asm cells can be obtained from bronchial biopsies obtained via bronchoscopy, we will examine endobronchial biopsies from corticosteroid-naïve, mild asthmatic subjects. in particular, we will examine whether ics have any effect asm mass, proliferation and expression of different contractile proteins (α-actin and myosin) and chemokines, and will assess in vitro the response of asm cells to stimulation by tgf-β and il-1β. we will also examine the effect of dexamethasone on chemokine release and induced proliferation in vitro before and after treatment with ics. we will examine the effect of inhaled corticosteroids in 12 subjects with mild asthma. the subjects will be studied during a baseline period and again after receiving treatment with inhaled corticosteroid therapy with budesonide turbohaler (400 ug bd) for 4 weeks. the results of these two periods will be compared. there will be 5 study visits. in the first two visits, the subjects will undergo spirometry with reversibility testing, a methacholine challenge test, skin prick tests and ige levels, measurement of exhaled nitric oxide, and subjects will complete an asthma control questionnaire and an asthma quality of life questionnaire. the third visit will be the day admission for the bronchoscopy. they will be given asthma control diary cards to complete during the 4-week treatment with ics and receive their ics turbohaler. at visit 4, they will have repeat spirometry and methacholine challenge to assess if there has been a change secondary to treatment with ics. the final visit will be for the second bronchoscopy, when the dairy card and ics inhaler will be collected, and the subjects will complete the asthma control and quality of life questionnaire.

Eligibility criteria:
inclusion criteria: * physician diagnosis of asthma * age 18-60 * intermittent asthma symptoms \< once/week * fev1\>80% of predicted * not on inhaled corticosteroid therapy exclusion criteria: * previous long-term use of inhaled corticosteroids (within 1 year of entry into study) * past history of hypersensitivity to budesonide * current smokers, or less than 3 years since quitting smoking * less than 4 weeks from an exacerbation * on steroid-sparing agent or immunosuppressant such as azathioprine, methotrexate and ciclosporin * concomitant anti-ige therapy * pregnancy * previous bronchoscopy within three months of this study

Keywords: asthma airway smooth muscle inhaled corticosteroids
treatment of conduct problems and depression

Conditions: Depression; Oppositional Defiant Disorder; Conduct Disorder

Summary: having both depression and conduct problems at the same time has been found to be associated with increased risk for the other and increased risk of negative outcomes. this study will develop an family based cognitive behavioral treatment protocol for youths with both conduct problems and depression, that will take be administered over the course of six months. youth with comorbid conduct problems and depression will be assigned to the experimental condition or treatment as usual in a community care setting. the treatment manual will be revised as needed. youth will be assessed before and after treatment to examine program potential. the goal of this research is to develop a more comprehensive outpatient treatment for youth with both conduct problems and depression.


Eligibility criteria:
inclusion criteria: * 8-14 years old * diagnosis of odd or cd * diagnosis of depression * speaks english exclusion criteria: * developmental/cognitive delays * substance dependence * psychotic disorder or symptoms

Keywords: depression conduct problems
analysis of risk factors for high intraocular pressure and retinal detachment recurrence after vitrectomy with silicone oil tamponade in retinal detachment patients

Conditions: Rhegmatogenous Retinal Detachment

Summary: this study is a retrospective study. patients who visited the ophthalmology clinic of the first affiliated hospital of chongqing medical university between september 1, 2024, and december 31, 2025, will be screened according to the inclusion and exclusion criteria mentioned below. after obtaining informed consent, clinical data of the subjects will be collected. the surgical procedure will involve "vitrectomy + retinal laser photocoagulation + retinal reattachment + silicone oil tamponade (+ cataract extraction + intraocular lens implantation)." observation indicators will be recorded at various time points postoperatively: 1 day, 1 week, 1 month, 3 months, 6 months, and before silicone oil removal. any emergent events occurring during the trial will be treated accordingly. finally, data will be statistically analyzed to identify risk factors for high intraocular pressure and retinal detachment recurrence in patients with rhegmatogenous retinal detachment.


Eligibility criteria:
inclusion criteria: * 1. diagnosed with "rhegmatogenous retinal detachment". 2. aged over 18 years old, with normal mental and psychological status, regardless of gender. 3. intraocular pressure of both eyes is less than 21 mmhg before surgery, and having no personal or family history of glaucoma. 4. cup - to - disc ratio (c/d) in fundus examination is less than 0.5 for both eyes. 5. those who understand the purpose of this study, sign the "informed consent form" and have a high degree of compliance. exclusion criteria: - 1. those with high intraocular pressure before surgery and suffering from ophthalmic diseases such as glaucoma; 3. those with acute or chronic systemic infections and hematological diseases; 4. those with a history of mental and psychological diseases; 5. those with incomplete survey data or unable to cooperate with this research. 5. those with traumatic rhegmatogenous retinal detachment; 6. those with active ocular infectious lesions in either eye; 7. those with severe refractive media opacity (such as corneal nebula, corneal leukoma) in the target eye, which affects imaging examinations during postoperative follow - up. 8. those with a history of congenital structural abnormalities in the target eye; 9. those who have undergone vitrectomy for other vitreoretinal diseases in the target eye before screening; 10. those whom the researchers consider unfit to participate in this clinical trial.
efficacy and safety of df289 plus df277 otic solution in the treatment of acute otitis externa

Conditions: Acute Otitis Externa

Summary: the purpose of this study is to determine if a combination of an antibiotic plus a corticosteroid is safe and effective in treating aoe


Eligibility criteria:
inclusion criteria: * uncomplicated aoe of less tan 21 days, defined as a total symptom score of at least 2 for otalgia, 2 for edema and 1 for otorrhea * brighton grading of ii or iii * culture-based diagnosis of acute bacterial otitis externa * willingness to refrain from swimming through end of the study exclusion criteria: * previous episode of aoe within 4 weeks prior to enrollment, or 2 or more episodes of aoe within 6 months prior to the enrollment. * tympanic membrane perforation * any condition or situation likely to cause the patient to be unable or unwilling to comply with study treatment or attend all study visits * any condition in the patient or parent/guardian that, in the judgment of the principal investigator, could compromise patient safety, limit the patient's ability to complete the study, and/or compromise the objectives of the study
the relaxation and blood pressure in pregnancy (rebip) study

Conditions: Hypertension; Hypertension, Pregnancy-Induced; Pre-Eclampsia

Summary: over 10% of women have high blood pressure during their pregnancy which may affect their health or that of their baby. there are currently no methods to prevent most high blood pressure in pregnancy and some treatments are not desirable for use in pregnancy. previous research indicates that simple relaxation methods can reduce blood pressure and anxiety levels for some people, but this has not been well-studied, especially during pregnancy. this pilot study is intended to determine how guided imagery (imagining relaxing scenes) affects blood pressure and anxiety, and to assess how satisfied women are with this technique. sixty-six pregnant women with high blood pressure will be randomly assigned to (1) listen to a guided imagery audio-compact disc or (2) quiet rest, at least twice-daily for 4 weeks. all women in both groups will receive all usual care, plus will have their blood pressure measured regularly during 1 day per week for 4 weeks. this study will determine if imagery lowers maternal blood pressure, and if further research on imagery effects on pregnancy health outcomes is feasible.


Eligibility criteria:
inclusion criteria: * pregnant, and less than or equal to (\<) 36 weeks, 6 days gestation * at least two prenatal blood pressure readings \> 90 mmhg diastolic * has had clinical investigation of the hypertension * hearing acuity adequate to hear verbal and audiotaped instructions * planning to give birth at one of the study site health centres * competent to give informed consent exclusion criteria: * likely to deliver within 10 days (including women with diastolic bp \>110 mmhg, or systolic bp \>170 mmhg; unstable diabetes, concurrent antepartum hemorrhage, preterm labour, and/or other significant medical) * prescribed antihypertensive medication at baseline * documented psychotic illness * unable to understand and read english

Keywords: pre-eclampsia hypertension blood pressure pregnancy randomized clinical trial guided imagery relaxation psychophysiology mind-body
use of graft tensioner device in acl (knee) repair

Conditions: Torn Anterior Cruciate Ligament (Knee)

Summary: compares tension of an acl graft when using a commercial device vs. the tension of the graft applied by a physician during surgery.


Eligibility criteria:
inclusion criteria: torn acl amenable to surgery exclusion criteria: