Kornimate/medical-research-clean huggingface dataset:
utility of high-resolution ultrasound to evaluate dorsal osteophyte

Conditions: Exostosis

Summary: this study will evaluate the usefulness of ultrasonography in detecting dorsal osteophytes associated with claw nails compared to radiographs. the hypothesis will be that the larger the size of the osteophyte, the greater the nail curvature. nail curvature and osteophyte height will be measured in patients with clamp nails. nail-phalange distance will also be measured with radiography and ultrasonography. the investigators to find a positive correlation between nail curvature and osteophyte height. furthermore, a strong agreement is expected between both imaging techniques to measure nail-phalange distance. ultrasonography could constitute a safe and effective alternative to radiology for detecting dorsal osteophytes in claw nails, especially in mild cases, follow-ups or young patients.

main objective: the investigators aim to explore the possible relationship between the degree of dorsal curvature of the nail plate and the height of the dorsal osteophyte in subungual exostosis patients before and after surgery. secondary objectives: the investigators will compare the distance between the nail surface and the dorsal cortex of the distal phalanx using plain radiographs and high-resolution ultrasonography. materials and methods: this is an interventional study patients experiencing nail pain due to clamp nails will be enrolled. two groups will be formed depending on the presence of exostosis or not. patients diagnosed with subungual exostosis who consent to surgery will undergo preoperative measurements. after surgery, these patients will be re-evaluated to assess the restoration of normal nail curvature values, as well as the height of the exostosis or its distance from the nail. measurements: nail curvature will be assessed using the nail curvature index, and nail height and thickness will also be measured. dorsal osteophyte height will be assessed on radiographs and ultrasound images before and after treatment. expected results: the investigators anticipate a positive correlation between dorsal osteophyte height and nail curvature. in addition, they do not expect significant differences in nail-phalange distance measurements between radiography and ultrasonography. conclusions: high-resolution ultrasonography may emerge as an alternative diagnostic tool to detect subungual exostosis without exposure to ionizing radiation.

Eligibility criteria:
inclusion criteria: * clinical and radiological diagnosis of claw nail in at least one toe. * pain associated with claw nail for at least 1 month. exclusion criteria: * pregnancy or breastfeeding * previous trauma or surgery on the affected toe * systemic diseases such as diabetes mellitus, renal insufficiency, rheumatoid arthritis * current or previous treatment for ingrown toenail within the last year * severe digital deformities (e.g. hallux valgus, hammer toe, claw toe)

Keywords: dorsal osteophyte ultrasound nail curvature nail-phalanx distance
omega 3 fish oil supplements vs. placebo for patients with non-alcoholic steatohepatitis (nash)

Conditions: Non-alcoholic Steatohepatitis; Fatty Liver

Summary: nonalcoholic steatohepatitis (nash) occurs in 2-3% of the us population and carries a 15-20% chance of progression to cirrhosis. it is closely associated with obesity, hyperlipidemia and insulin resistance. therapy usually includes recommendations to increase exercise and to begin weight reducing diets but these goals are variably achieved and their relative effects in conjunction with pharmacological intervention have not been well defined. moreover, these lifestyle changes can confound results of treatment trials if not quantified through conditioning testing and measures of body fat. polyunsaturated fatty acids, especially formulation rich in omega-3, are widely accepted and endorsed in the medical community for their beneficial effects on hyperlipidemia and coronary disease risk reduction. recent data suggests that omega-3 fatty acids ameliorate hepatic steatosis in humans and in animal models of nash by reducing hepatic fat content. we hypothesize that a one year course of omega-3 fatty acid (3gm/day) will produce improvement in nash histological injury independent of changes in weight (bmi) or degree of conditioning measured by the lactate threshold. the effects of the supplement will be compared to a placebo group and controlled for these lifestyle changes.


Eligibility criteria:
inclusion criteria: 1. nash with nas (nash activity score) of \>4 evident on a biopsy performed within 6 months of enrollment. 2. age 21 years or older. 3. bmi 25 or greater. 4. ability to provide informed consent. exclusion criteria: 1. cirrhosis evident clinically or on biopsy. 2. secondary forms of nash such as that seen with bariatric surgery or medication induced from such medications as methotrexate, amiodarone, tamoxifen, corticosteroids. 3. current or past history of diabetes or hyperlipidemia requiring specific drug therapy (see below). 4. current use of a weight loss medicine, such as a 'fat-burner' or similar agent 5. alcohol consumption \> 30 g/day, currently or for more than 3 consecutive months within 5 years. 6. other liver disease (hepatitis c,b, wilson's, autoimmune, ct-1-antitrypsin and hemochromatosis or hiv 7. pregnancy or unwillingness to use an effective form of birth control for women of child bearing years. 8. renal insufficiency (creatinine \> 2), symptomatic coronary, peripheral or neurovascular disease, symptomatic heart failure or advanced respiratory disease requiring oxygen therapy. 9. inability to provide informed consent. 10. any condition in the opinion of the primary investigator that would contraindicate the patient's participation.

Keywords: steatohepatitis nash nafld omega 3 fatty acids exercise conditioning
impact of the arteriovenous fistula puncture technique on the hemodialysis session for patient and caregiver

Conditions: Arterio-venous Fistula, Puncture, Chronic Desease

Summary: 40000 patients are hemodialysis each year in france . in the case of chronic care, 78% of patients have an arteriovenous fistula. in order to perform the hemodialysis session, 2 techniques of puncture of the fistula are possible: * bevel puncture upwards then flipping the needle * or puncture bevel down. at present, there is no consensus or study on the technique of puncture fistula which generates different professional practices.


Eligibility criteria:
inclusion criteria: * patient in chronic renal failure treated by hemodialysis with native arteriovenous fistula as a vascular approach. * adult of age and sex indifferent. * normal puncture of the fistula with two needles (bipuncture). * fistula use for more than 3 months. * beneficiary of medicare or state medical aid. * no opposition to participation in the study. exclusion criteria: * patient who does not speak and does not understand french. * hemodialysis patient awaiting a transplant by a living donor. * patient with more than 2 avf dilatations in the last 6 months. * patient with prosthetic arteriovenous fistula.
effect of consumption of non caloric sweeteners and insulin sensibility

Conditions: Insulin Sensitivity

Summary: this study will compare the effect of acute consumption of two carbonated drinks, sweetened with sugar or with non-caloric sweeteners, over the insulin response of healthy adults who normally consumed foods or drinks that contain non-caloric sweeteners

during the last decades there has been a sustained increase in prevalence of overweight and obesity and, along with it, of chronic noncommunicable diseases. there have been addressed various management strategies, including sugar replacement for non-caloric artificial sweeteners (nas). nevertheless, in several cohort studies it has found the opposite effect, it has observed associations between the consumption of nas with greater weight gain and increased risk of type 2 diabetes and metabolic syndrome. in clinical trials, in both humans and mice, there has been greater association with glucose intolerance, being 3 possible mechanisms: 1) dysbiosis of the intestinal microbiota; 2) altered regulation of appetite cephalic phase and secretion of glucagon like peptide-1 (glp-1); and 3) increased intestinal glucose absorption via increased sodium-glucose linked transporter-1 (sglt-1) and glucose transporter 2 (glut2), transporters to glucose absorption. in the following review the major findings in the literature regarding the consumption of nas and its deleterious effects on human health will be studied.

Eligibility criteria:
inclusion criteria: * body mass index (bmi) between 18,5 - 24,9 kg/mt2 * healthy men or women * fasting plasma glucose \< 100 mg/dl exclusion criteria: * consumption of drugs affecting glucose metabolism, antihypertensives or lipid lowering * subjects with insulin resistance, type 1 or 2 diabetes, dyslipidemia, hypertension; heart, liver or kidney disease, respiratory failure, stroke, or any chronic illness. * pregnant women. * being treated to gain or lose weight. * history of recurrent episodes of acute diarrhea.

Keywords: high-intensity sweeteners non-nutritive sweeteners artificial sweeteners glucose intolerance
collection of malignant ascites, pleural fluid, and blood from people with solid tumors

Conditions: Ovarian Cancer; Primary Peritoneal Cancer; Fallopian Tube Cancer; Cancer

Summary: background: researchers want to study fluids and blood of people with cancer. the fluids are from the abdomen and around the lungs. studying these might help researchers learn about the biology of cancer. this may lead to better ways to treat cancer. objectives: to study the biology of cancer. eligibility: adults 18 and older with malignant solid tumors. design: participants will be screened with medical history, blood tests, and confirmation of diagnosis. participants will have samples taken at regularly scheduled procedures. fluids from the abdomen and/or lungs will be taken as part of the procedures. blood will be taken separately. participants may be asked to give more samples at future procedures.

background: -malignant ascites or pleural effusions are often seen in patients with solid tumor malignancies. -malignant ascites is proinflammatory with many cytokines present and acts to promote tumor cell growth. -the cellular composition of malignant ascites consists of lymphocytes, macrophages and monocytes. -serum monocytes and lymphocytes play a role in the native host anti-tumor immune mediated mechanisms. -a paracentesis or thoracentesis is often done for symptomatic relief from the malignant fluid collection. primary objective: -to obtain blood samples and ascites and pleural effusion samples from patients with solid tumor malignancies, with the intent of performing translational studies related to cancer. eligibility: * patients greater than or equal to 18 years of age. * diagnosis of malignant solid tumor. * patients must be able and willing to provide informed consent. design: -we will collect approximately 200cc-5l ascites from patients that are undergoing a therapeutic paracentesis or thoracentesis. no thoracentesis or paracentesis will be performed solely for research purposes. -the fluid will be collected during the medical procedure and may be collected at more than one time point. -we will also collect 30ml of peripheral blood. this will be from patients who are being seen in follow up, consultation, or presenting for enrollment on a clinical trial.

Eligibility criteria:
* inclusion criteria: * participants greater than or equal to 18 years of age with histologically proven malignant solid tumors * ability and willingness to provide informed consent to participation. * participants with malignant solid tumors with a clinical indication for a thoracentesis or paracentesis. exclusion criteria: -children \< 18 years of age are not eligible.

Keywords: malignant effusion composition paracentesis thoracentesis natural history
the use of the excor active driving unit for mobilization of pediatric patients with ventricular assist device support

Conditions: Heart Failure; Cardiomyopathies; Ventricular Dysfunction; Heart Diseases; Cardiovascular Diseases

Summary: the purpose of this observational study is to evaluate the performance of the berlin heart excor active driving unit while being used with the approved excor ventricular assist device system.

the study has a prospective, multicenter, international, single arm, observational design. study enrollment is expected to take 18 months and subjects will be followed until they reach an outcome or for 45 days on the excor active driving unit. the overall study duration is expected to be approximately 20 months.

Eligibility criteria:
inclusion criteria: * pediatric patients meeting all indications as specified in the current version of the instructions for use (ifu) of the excor® active system, * age \< 18 years, * patient and legal guardian has consented via signature on the study informed consent form, * patient is able to get mobilized according to hospital standard and is currently supported with the ikus driving unit. the decision if a patient is able to get mobilized is at the discretion of the investigator. exclusion criteria: * patient has any contraindication as specified in the current version of the ifu of the excor® active system, * patient and/or legal representative has not given written consent to participate in the study (non-consent), * females of childbearing age who are not on contraceptives or surgically sterile or who are pregnant.

Keywords: excor ventricular assist device excor active mobilization pediatric
predicting survival after surgical resection for the entire spectrum of anatomically resectable hcc

Conditions: Hepatocellular Carcinoma Resectable

Summary: clinical outcomes after surgical resection in hcc is a continuum and is clearly related to tumor burden but needs better definition. the researchers describe the use of the "metro ticket" approach to analyze surgical outcomes over the whole spectrum of anatomically resectable hcc to define overall survival including intermediate stage tumors (bclc b). the analysis the researchers provide in this study enables the clinician to select the optimal surgical resection candidate based on robust long term survival data. in addition, study compares outcome for open surgery vs laparoscopic surgery, survival outcome for viral and non-viral hcc using albumin-bilirubin (albi) for more comprehensive study result.

patients who underwent surgical resection (both open surgery and laparoscopic surgery) for hcc from 1st january 2000 to 30th june 2018 by the joint hepato-pancreato-biliary surgery service at the singapore healthcare group of hospitals (singapore general hospital and the national cancer centre singapore) were retrospectively identified from a prospectively kept institutional database. the assessment of the size, number of nodules and vascular invasion of hcc were based on pre-operative ct/mri imaging and pathological assessment of the resected specimens. all resections were histologically confirmed as hcc. patients with macrovascular invasion and extrahepatic invasion were excluded from analysis as were patients resected for other palliative intents (e.g. ruptured hcc).

Eligibility criteria:
inclusion criteria: 1. unequivocal diagnosis of hepatocellular carcinoma (hcc) by histology 2. patients who underwent surgical resection for hcc exclusion criteria: 1. patients who underwent liver resection for other malignancies ie cholangiocarcinoma 2. patients with hcc who did not undergo liver resection. 3. patients with hcc who underwent liver transplant.

Keywords: metroticket approach surgical resection hepatocellular carcinoma (hcc)
occupational therapy home programs in children with down syndrome

Conditions: Down Syndrome; Occupational Therapy; Feeding Problem

Summary: children with down syndrome frequently encounter difficulties with sensory functions and feeding, such as oral sensory processing issues and developmental disorders. the aim of this study was to examine the effects of an occupational therapy home program on the sensory functions and feeding issues of children with down syndrome.

although there are studies that investigate nutritional issues in children with down syndrome, no well-structured, high-evidence, and individual-centered studies have been found. the literature assumes a relationship between the sensory functions and nutritional status of children with down syndrome. therefore, further studies are needed to develop intervention programs to prevent sensory processing and nutritional problems. this study aims to evaluate the effectiveness of occupational therapy home programs in improving sensory functions and feeding problems in children with down syndrome. the study focuses on evidence-based practices to assess the impact of these programs compared to not providing them. the study will be conducted with children diagnosed with down syndrome who have applied to the pediatrics unit of the department of occupational therapy at hacettepe university faculty of health sciences. the study comprises pre-evaluation, final evaluation, and intervention stages. following the initial evaluation, an occupational therapy home intervention program will be implemented for the children before and after each meal, seven days a week, for eight weeks. evaluations will be repeated after the eight-week period.

Eligibility criteria:
inclusion criteria: * be between the ages of 3-10 * having down syndrome * families agree to participate in the study exclusion criteria: * having previously received sensory integration and/or occupational therapy treatment * having a secondary diagnosis other than down syndrome (mental retardation, etc.)

Keywords: down syndrome occupational therapy home program sensory function randomized control trial
lucas chest compressor versus manual chest compression in out-of-hospital sudden cardiac arrest. lucat trial

Conditions: Sudden Cardiac Arrest

Summary: the goal of this study is to show the superiority in survival at hospital admittance and in neurological outcome on hospital discharge of continuous mechanical chest compression using lucas device versus manual chest compressions in patients who suffered an out-of-hospital cardiac arrest.

the primary goals of the trial are: * to show a survival increase at hospital admittance after out-of-hospital cardiac arrest of patients treated by continuous chest compressions lucas device compared with patients treated by manual chest compressions. * to evaluate neurological outcome on hospital discharge, in two centres (vall d'hebron hospital and josep trueta hospital).

Eligibility criteria:
inclusion criteria: * age: between 18 and 80 years , * suffering from non traumatic or an unexpected sca, * sca witnessed (seen, heard or monitored), * attended by an advanced support ambulance (served by doctor or nurse) in barcelona city, or in the girona or lleida area * time between alarm-call to sem 061 and reaching patient is less than 12 minutes. exclusion criteria: * biological signs of death * age under 18 or over 80 years * trauma caused cardio respiratory arrest (cra), including hanging * secondary cra or intoxication * return of spontaneous circulation previous to arrival of sem's medical team * known pregnancy * inadequate size for lucas device * anything in the study that can delay treatment

Keywords: out-of-hospital cardiac arrest (ohca) chest compressions lucas device
efficacy of pain neuroscience education and pre-anesthetic assessment in reducing levels of anxiety, stress and pain in patients undergoing elective total abdominal hysterectomy (enah study)

Conditions: Pain, Chronic; Pain, Postoperative; Anesthesia; Surgery; Anxiety; Stress

Summary: through this quantitative, multivariate factorial experimental research of the parallel randomized clinical trial type, the investigators will try to analyze the effectiveness in reducing levels of anxiety, stress and pain through pre-anesthetic assessment and pain neuroscience education in patients undergoing elective total abdominal hysterectomy.

hysterectomy is a common surgical procedure with a low risk of major complications. however, some women experience long-lasting complications, including chronic postsurgical pain, which can have a negative impact on their quality of life. the population will be made up of women with elective total abdominal hysterectomy scheduled surgery at the university hospital of puebla buap, in the city of puebla, mexico. then the investigators will carry out an pre-anesthetic evaluation will be carried out and an pain neuroscience education session will be carried out. once patients are ready for surgery, the investigators will carry out an invasive monitoring will be performed in the post-anesthesia care unit. the blood pressure of the participants will be monitored non-invasively. they will also be monitored with electrocardiogram and pulse oximetry.

Eligibility criteria:
inclusion criteria: 1. anesthesia physical classification system: i, ii or iii according to the classification of the american society of anesthesiology. 2. acceptance of informed consent 3. schooling of at least 12 years (basic primary and secondary). exclusion criteria: 1. illiterate 2. inflammatory rheumatic disease 3. major neurological or psychiatric disease, intellectual disability (mental retardation) or learning disorders at the premorbid level or severe language comprehension problems.

Keywords: pain neuroscience education hysterectomy pre-anesthetic assessment
exogenous ketone supplementation in females with polycystic ovary syndrome

Conditions: PCOS

Summary: polycystic ovary syndrome (pcos) affects 1 in 5 females of reproductive age. commonly characterized as a disorder of infertility, pcos is often accompanied by 3 potent cardiovascular disease (cvd) risk factors: insulin resistance, endothelial dysfunction, and elevated blood pressure. accordingly, pcos is associated with the development of cvd, the second leading cause of death in females in canada. however, effective treatments to improve cardiovascular health in pcos are lacking. exogenous ketone monoester (kme) ingestion has been shown to improves outcomes associated with insulin resistance, endothelial function, and blood pressure regulation in healthy individuals and individuals predisposed to cvd. therefore, oral ketone supplements offer a practical and effective strategy for improving cardiovascular health; however, this treatment has yet to be evaluated in pcos. therefore, the overall goal of this project is to employ kme ingestion to improve markers of cardiovascular health in females with pcos. on two different days, participants will consume either a beverage containing a ketone supplement or a beverage containing a placebo supplement. the objectives are to compare responses between kme and placebo ingestion, and examine all outcomes related to cardiovascular health in females with pcos in comparison with female controls of similar age and body mass index. the effects of kme ingestion will be quantified on: 1) glycemic control during an oral glucose tolerance test; 2) endothelial function using the flow-mediated dilation test; 3) blood pressure and acute blood pressure regulation; and 4) hemodynamic responses to acute exercise.


Eligibility criteria:
inclusion criteria: * all female participants will report female sex assigned at birth * all participants will be aged 18 to 40 * pcos diagnosis exclusion criteria: * current smokers or a prolonged history of smoking * presence or history of overt cardiometabolic disease (e.g., stage 2 hypertension, diabetes, heart disease), neurologic disease, or endocrinopathy (with the exception of pcos) * current pregnancy or currently breastfeeding * current use of medications which may affect our outcomes of interest (e.g., anti-hypertensives, anti-androgens, metformin)

Keywords: polycystic ovary syndrome ketone monoester ingestion insulin resistance endothelial function blood pressure oral glucose tolerance test flow mediated dilation handgrip exercise neurovascular transduction cold pressor test