Kornimate/medical-research-clean huggingface dataset:
modified müller's muscle-conjunctival resection internal ptosis repair using fibrin glue

Conditions: Ptosis, Eyelid; Ptosis; Eyelid, Congenital; Surgical Procedure, Unspecified

Summary: fibrin glue is widely used in ophthalmology for homeostasis and tissue recovery. it is commonly used in ocular surface surgeries such as pterygium removal and conjunctival lesions excisions. in müller's muscle-conjunctival resection (mmcr), sutures are used to reconnect the conjunctiva and muller muscle, which causes discomfort and pain for the patient. the investigators' goal is to explore using fibrin glue instead of sutures in mmcr surgeries to shorten the procedure's length and alleviate patients discomfort and pain. this is especially important in the management of children suffering ptosis, where sedation and even general anaesthesia is required for sutured removal as a secondary procedure.

fibrin glue is widely used in ophthalmology for homeostasis and tissue recovery. it is commonly used in ocular surface surgeries such as pterygium removal and conjunctival lesions excisions. müller's muscle-conjunctival resection (mmcr) is the most common surgery for ptosis correction and is normally performed under local anaesthesia. in mmcr, a portion of the muller and conjunctiva is resected, and sutures are used to reconnect the remaining edges. the suturing process requires several minutes and causes discomfort to the patient. in addition, many patients experience post operative discomfort due to the touch of the sutures in the superior ocular surface until their removal about 7-14 days post op. moreover, the sutures removal process is commonly unpleasant, and in the pediatric patients requires sedation or general anaesthesia. the investigators' goal is to explore using fibrin glue instead of sutures in mmcr surgeries to shorten the procedure's length and alleviate patients discomfort and pain. this is especially important in the management of children suffering ptosis, where sedation and even general anaesthesia is required for sutured removal as a secondary procedure. methods: a prospective randomized study. patients will be randomized into traditional mmcr using sutures, vs. mmcr using tisseel glue. follow up will take place 1 day, 7 days, 1 month and 3 months post op. main outcome measures included patient reported outcome such as pain grade and discomfort, and success of ptosis repair surgery defined by improvement in margin reflex distance, symmetry of upper eyelid position, and incidence of complications.

Eligibility criteria:
inclusion criteria: patients with ptosis referred to müller's muscle-conjunctival resection (mmcr) exclusion criteria: previous eyelid surgery

Keywords: ptosis müller's muscle-conjunctival resection (mmcr) fibrin glue
car-t-19 cells for patients with cd19+ relapse/refractory b-all

Conditions: CD19+ Relapse/Refractory B-ALL

Summary: this is a single-arm, open-label phase i study to determine the safety, tolerability, and recommended dose (rd) of car-t-19 cells for patients with cd19+ relapse/refractory b-all under the age of 25.

b-cell acute lymphoblastic leukemia (b-all) accounting for 85% of all all cases, is a common hematological malignancy in children and adults. cd19 is a widely expressed antigen in both normal b cells and b cells-derived leukemia and lymphomas. this is a single-arm, open-label phase i study of car-t-19 (anti cd19 scfv chimeric antigen receptor t) cells for patients with cd19-positive relapse/refractory b-all under the age of 25. primary endpoint is to determine the safety, tolerability, and recommended dose (rd) of car-t-19. secondary endpoints measure orr, os and others.

Eligibility criteria:
inclusion criteria: * patients with relapse/refractory b-all. * tumor cells from bone marrow or peripheral blood are measured cd19+ with 3 months before enrollment. * karnofsky score ≥ 70 or lansky score ≥ 50. * patients who have a life expectancy of at least 12 weeks. * understand and voluntarily sign informed consent and are willing to comply with laboratory tests and other research procedures. exclusion criteria: * patients with extramedullary relapse (emr). * patients with genetic diseases, burkitt lymphoma and leukemia or other malignancies. * patients positive for any of the following: hbsag, hbv-dna, hcv-ab, hcv-rna, hiv-ab, tp-ab, ebv-dna or cmv-dna. * patients with other uncontrolled infection. * patients who received anti-cd19 / anti-cd3 therapy, or any other anti-cd19 therapy. * patients with active grade ii-iv gvhd within 3 months prior to screening. * tumor cells are detected in cerebrospinal fluid. * patients who received hsct within 3 months prior to screening. * anticipated other clinical trials within 4 weeks before this trial * pregnant or lactating women. * any condition that would, in the investigator's judgment, make it unsuitable for the donors to be enrolled.

Keywords: b-all car-t
long-term follow-up of radiofrequency to articular branches of the femoral and obturator nerve in chronic hip pain

Conditions: Conventional Radiofrequency Thermocoagulation Application to the Articular Branches of the Femoral and Obturator Nerve; Chronic Hip Pain

Summary: it has been observed that the deterioration in the physical performance of the hip, the medical need before the specialist consultation and the deterioration in the health status can progress treatment\[3\]. when conservative treatment methods such as physical therapy and weight change, the use of walking aids (such as a cane) and analgesic agents are used, these interruptions usually provide short-term and partial benefits. after the application of medical treatment procedures, hip prostheses are usually separated. however, the additional diseases of the patients, the fact that the surgery is a major surgery and the mortality rate is high, and the life of the prostheses used are limited have led to the search for alternative pain palliation. hip joint radiofrequency thermocoagulation is a procedure performed in our clinic. in this study, we aimed to examine the long-term effects of hip rft on pain and functional capacity changes in patients.

after obtaining hospital ethics committee approval, it was planned to retrospectively examine adult patients over the age of 18 who applied to the outpatient clinic of the department of algology, adütf, between may 2021 and september 2023 and who underwent elective conventional radiofrequency thermocoagulation (rft) procedure to the articular branches of the femoral and obturator nerves due to chronic hip pain. the prospective studies conducted in our clinic titled "treatment of chronic hip pain with conventional radiofrequency thermocoagulation to the articular branches of the femoral and obturator nerve" and "comparison of conventional radiofrequency thermocoagulation to the articular branches of the femoral and obturator nerve in chronic hip pain with intra-articular steroid injection and pericapsular nerve group (peng) block" (theses of assistants sevilay şimşek karaoğlu and bilge ergün, respectively) will include patients who underwent conventional rf. in the studies, patients who underwent elective conventional radiofrequency thermocoagulation (rft) to the articular branches of the femoral and obturator nerve were followed up for up to 6 months. the follow-up of the patients in our clinic is ongoing. in our study, the long-term follow-up of these patients will be evaluated retrospectively at 12 months and 24 months.

Eligibility criteria:
inclusion criteria: 1. being over 18 years of age 2. having received written consent 3. those with chronic hip pain lasting longer than 3 weeks exclusion criteria: 1. major psychiatric disease 2. patients with lumbar pressure pain or referred pain 3. patients using anticoagulant agents 4. patients with infection in the area to be treated 5. those with local anesthetic allergy 6. those with betamethasone allergy 7. pregnant women

Keywords: chronic hip pain radiofrequency thermocoagulation articular branches of the femoral and obturator nerve
serratus anterior plane block versus intercostal nerve block for postoperative analgesia

Conditions: Analgesia; Postoperative Pain; Lung Cancer

Summary: a prospective randomized controlled study was undertaken to compare the postoperative analgesic effect between ultrasound-guided serratus anterior plane block and intercostal nerve block after video-assisted thoracoscopic lobectomy.

post-thoracotomy pain is one of the most notorious postsurgical pains that one can experience. the pain is known to last for an extensive period of time with significantly high intensity. in field of thoracic surgery, video-assisted thoracoscopic surgery has been played an important role in alleviating the postoperative pain. in field of anesthesiology, various attempts to alleviate post-thoracotomy pain have been tried along advancement of thoracic surgical techniques. it began with postoperative medication of non-steroid anti-inflammatory drugs, opioids and progressed into implementations such as local analgesia, thoracic epidural block, paravertebral block, intercostal nerve block, interpleural block and serratus anterior plane block. many analgesic methods have been applied to alleviate postoperative pain in patients who have undergone thoracoscopic surgeries. however, there are no prospective randomized controlled studies between intercostal nerve block and serratus anterior plane block in video-assisted thoracoscopic lobectomy. the main purpose of this study is to compare and analyze the effects between conventional intercostal nerve block and newly introduced serratus anterior plane block in lung cancer patients who have undergone video-assisted thoracoscopic lobectomy. this prospective study will discover the efficacy and differences between two methods.

Eligibility criteria:
inclusion criteria: * lung cancer * american society of anesthesiologists (asa) i-iii class * video-assisted thoracoscopic lobectomy exclusion criteria: * previous history of allergy to local anesthetics * psychological disorder * chronic analgesics or sedatives use * coagulopathy * the presence of systemic infection or local infection at injection site * pregnancy
effects of proprioceptive sensitivity stimulation via the sura electrodevice on kinematics, kinetics and spatiotemporal parameters of gait.

Conditions: Stroke

Summary: recovery of function in people with central nervous system (cns) injury after stroke is very much like a relearning process that takes advantage of preserved sensorimotor circuits. relearning can be optimised by providing appropriate proprioceptive (or deep sensory) information to the spinal cord with the aim of maximally engaging the preserved neural circuits. the development of the sura electrodevice offers this sensitive input mechanism, within the botton up therapies. and through research on its use, the impact on the different dimensions related to gait and its components, and the translation to the functional reality of the person, will be evaluated.

objective: to assess whether the sura electrodevice improves relevant aspects of dynamic balance in stroke survivors. methods:the design is a prospective longitudinal randomised controlled trial with simple masking by the examiner to be carried out at the facilities of the ricard i fortuny social and health centre (cssv rif). the first phase of the intervention (device-on rest phases) will consist of the activation of the device on the muscle motor points of the medial belly of the gastrocnemius, soleus and peroneus muscles. the motor points are the site of penetration of the motor nerve fibers and the highest concentration of motor plates in the muscle, which when stimulated produce the maximum effective muscle contraction. the second phase (off activity-device phase) consists of carrying out the therapy as the patient had been doing normally in the neurorehabilitation department at the center at a rate of 3 sessions per week on an outpatient basis according to their individualized needs. the control group will perform the same activity, but without the device activated during the device-on rest phases and adapted to the needs of each participant in their usual sessions without a standardized protocol.

Eligibility criteria:
inclusion criteria: * unilateral hemispheric stroke (ischaemic or haemorrhagic) diagnosed by mri or ct scan, at least 3 months after onset of stroke * ability to walk at least 10m (irrespective of the need for assistance) * weakness in ankle dorsiflexion of the paretic limb (tfm\>3) * ankle rom \>30° and 0° of foot dorsiflexion in knee extension * age between 18 and 85 years * mini-mental state examination (mmse) \> 24 score, non-disabling cognitive impairment * presence of clonus and hyperresistance to passive joint movement. exclusion criteria: * diagnosis of cognitive, visual or cardiorespiratory disorder (including cardiac pacemaker placement, heart failure and arrhythmia) * orthopaedic intervention for ie * balance disorders with vestibular features * skin diseases * botulinum toxin treatment within the last year. * in addition, subjects who had participated in other studies in the last six months that could interact with the current study will be excluded.
focal cortical atrophy after myocardial internal capsule

Conditions: Ischemic Stroke

Summary: primary purpose of the trial is to demonstrate the arisen of focal cortical atrophy, localized in the ipsilateral primary motor area, measured in mm, three months after infarction of internal capsule. the patient is compared to himself between day zero to ten and three months. the study hypotheses are: * a focal cortical atrophy of the ipsilesional primary motor area occurs after cerebral infarction of the internal capsule. it is measurable accurately and reproducibly by mri at three months. other brain areas within the voluntary motor system will also be explored (supplementary motor area, pre motor area). * this atrophy is correlated with achievement of pyramidal tract, assessed by the fractional anisotropy of its fibers. * this atrophy is correlated with disability at three months, assessed by rankin score.

twenty-two patients with ischemic stroke, subcortical, involving the internal capsule, will be included. each patient will be compared to himself, on day zero to ten and three months. an mri will be performed between day zero and ten, then three months of infarction sequences with traditional threed enabling acquisition and tractography and the measurement of cortical thickness is in mm the measurement of fractional anisotropy of the pyramidal tract a clinical evaluation will be done between day zero and day ten then three months, using a neurological score (nihss), a score of functional disability (rankin) and more analytical and sensitive tests such as dynamometer, the finger tapping test and test new plugs.

Eligibility criteria:
inclusion criteria: * patients of 18 to 90 years old. * subcortical stroke * achievement of the internal capsule, according to mri * ability to perform mri within 10 days after the onset of symptoms * nihss over or equal 2 and \< 20 * rankin score over or equal 1 and ≤ 5 * written informed consent after information about the protocol, from patients or reliable person if patient is in incapacity to sign * affiliation to a social security scheme exclusion criteria: * pregnant or nursing women * other cerebral lesion, concomitant or preexisting * concomitant disease causing unfavorable prognosis within 3 months after inclusion * pre-existing psychiatric illness * alcoholism or other chronic intoxication * cortical localization of the infarction * patient in a coma, who cannot be examined and evaluated * patient intubated, ventilated, sedated * cerebral hemorrhage, intra-parenchymal and / or subarachnoid * persons protected by law (guardianship, curators and judicial protection) * contraindications to magnetic resonance examination: pacemaker, metal implants, neurostimulators, clips neurosurgical wire sutures, staples, metal heart valves, ventricular bypass valve, metal workers, foreign eye, shrapnel, bullet , cochlear implants

Keywords: cortical focal atrophy stroke internal capsule corticospinal tract wallerian degeneration primary motor area.
procleix® dengue virus assay testing of individual donor samples from puerto rican and us blood donors - cts

Conditions: Dengue

Summary: the objective of this study is to test individual donor samples (idss) with the investigational dengue assay on the tigris system and to further characterize the dengue assay in the clinical setting.


Eligibility criteria:
inclusion criteria: * donor must meet all the blood collection sites' standard eligibility requirements. * donor and/or legally authorized representative must be willing to undergo the site's routine informed consent process prior to study participation.
have a good grasp of the worldthe world

Conditions: Schizophrenic Disorders

Summary: brief summary: in schizophrenia, dislocation of psychic functions involving a loss of contact with reality is frequently found. a fragmentation of motor and sensory perceptions could be held responsible. however, automatic integration between perception and action is the necessary condition to be in "relationship with the world." affordance is the experimental link between object perception and potentially associated actions (gibson, 1977, 1979) explored by stimulus response compatibility (src) paradigm. with tucker \& ellis sensory motor compatibility task (1998), with a modified response device (responses given with grasp), we study the impact of motor activation on these affordance effects. in this study, a group of controls will also be included in order to understand, as precisely as possible, the mechanisms involved (i.e., interference between the perception of the object and the response gesture).

schizophrenic patients will perform: alert tea, (zimmermann and fimm, 2005), edinburgh laterality questionnaire (oldfield, 1971), iq test (iq: pm38, raven, 1960), and the panss (positive and negative syndrome scale, kay et al., 1987). controls will only perform the laterality questionnaire. then all will perform the affordance task, in which photographs of 20 objects of everyday life, typically graspable with one hand, are presented in 4 orientations. participants have to respond in a graspable device, as quickly as possible, if the object is presented upright or inverted.

Eligibility criteria:
inclusion criteria: * for patients: * a dsm-iv diagnosis of schizophrenia (men or women), * no change in antipsychotic medication and clinical status within four weeks prior to the study * for patients and control group • age ≥ 18 years et ≤ 55 years exclusion criteria: * history of head trauma, * neurological disease with cerebral repercussion or not stabilized serious physical illness; * psychotropic medication * disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal); exclusion criteria: * for patients: • iq \< 70 * for patients and control group * history of head trauma, * neurological disease with cerebral repercussion or not stabilized serious physical illness; * psychotropic medication * disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal);

Keywords: schizophrenia, affordance, perception-action binding, stimulus-response-compatibility
generation of organotypic liver cultures for the identification of biomarkers for the prevention and treatment of liver fibrosis

Conditions: Hepatic Fibrosis

Summary: low-level, interventional, biological and non-pharmacological study prospective intervention for the preparation of organotypic human liver slice cultures liver slice culture (hlsc) applying the protocol described by jiang and collaborators.

human liver slice culture hlscs will be used from non-tumor liver tissue collected by biopsy from patients undergoing abdominal surgery, who have signed informed consent and agree to perform a liver biopsy for the specific research protocol. the study is "low level interventional" when a small portion (approximately 10 mm in diameter) of liver tissue macroscopically free from parenchymal alterations obtained in the open at the site of surgery for primary or secondary liver tumors will be taken (hepatic metastases from colorectal, pancreatic or breast cancer). the goal is to create organotypic liver cultures (hlsc) derived from liver biopsies taken from patients undergoing abdominal surgery. for primary or secondary liver tumors for the molecular characterization of liver fibrosis. use hlsc to study the liver microenvironment and molecular determinants involved in fibrosis through single cell sequencing; compare the sequencing data obtained with hlsc with that obtained via characterization of a gemm whose generation is foreseen in the same project financed by the mos. to generate this gemm, the pro-fibrotic hipk2 gene was specifically deleted in the tissue liver (hipk2-liver knock-out, hipk2-lko) and liver fibrosis will be induced through a high-fat, low-choline diet.

Eligibility criteria:
inclusion criteria: * age over 18 years old; * patients for whom it is indicated to undergo abdominal surgery for tumors primary or secondary liver diseases; * patients who express informed consent to the study. exclusion criteria: * medical contraindication to performing a liver biopsy; * liver cirrhosis; * macroscopic signs of chronic liver disease; * moderate or severe steatosis; * cholestasis; * hepatic necrosis.
breathing exercises with and without aerobic training in patients with postural orthostatic tachycardia syndrome

Conditions: Postural Orthostatic Tachycardia Syndrome

Summary: postural orthostatic tachycardia syndrome (pots) is a chronic, multifactorial syndrome with complex symptoms of orthostatic intolerance. of the major complaints are breathlessness and exercise intolerance. the aim is to explore the potential impact of a physiotherapy intervention involving education and breathing control on dysfunctional breathing and improving exercise intolerance in pots. the study would be a randomised controlled trial. duration would be 4 week. patients will be randomly divided into two groups by lottery method. data will be collected through questionnaire from enrolled subjects in physical therapy department of liaqat hospital, lahore. experimental group will be treated by progressive breathing retraining exercise program-2 times a day for 15 minutes, initially controlled nasal breathing with progressively increasing the controlled pause, 4 times a day for 15 minutes, then both techniques will be performed together. in addition to this aerobic training will be assigned to both the groups. aerobic training will include cycling and treadmill- for 30 minutes\\day for 5 days\\week for 1 month. total 20 sessions. while the controlled group will receive only aerobic training which will include cycling and treadmill for 30 minutes\\day for 5 days\\week for 1 month. total 20 sessions. the dysfunctional breathing and exercise intolerance will be assessed through nijmegen questionnaire and veterans questionnaire respectively at 0 week, after 2 week and after 4 week. the data will be analyzed by spss version 25.


Eligibility criteria:
inclusion criteria: * only females * age: (15-45years) * +ve tilt table test * +ve 10 minutes standing test * nijmegen score \>22, * increase in hr\>30bpm; with no orthostatic fall in blood pressure.symptoms occuring in \>3 months exclusion criteria: * pregnancy * no cardiac or respiratory pathology * surgical history * participants in another research protocol * any other medical condition that confers greater morbidly than pots (e.g.,active cancer)

Keywords: postural orthostatic tachycardia syndrome dysfunctional breathing aerobic training exercise intolerance progressive breathing retraining