Kornimate/medical-research-clean huggingface dataset:
predictor analysis of acute radiation oral mucositis in npc patients treated with imrt/tomo combined chemotherapy

Conditions: Nasopharyngeal Carcinoma

Summary: radiation induced oral mucositis which may result in reduced quality of life is commonly seen during radiotherapy, especially combined with chemotherapy. this study is a prospective, single center, and exploratory study. two contour methods of oral mucosal will be used in this study. all detail information will be recorded prospectively. the aim of this study is to explore predictive factors of acute radiotherapy induced oral mucositis in nasopharyngeal carcinoma patients treated with new precise radiotherapy (intensity modulated radiotherapy or tomography radiotherapy) by using different dosimetric parameters and clinically relevant variables.

to prospectively identify the predictive value of different dosimetric parameters and assess the predictors of acute radiation oral mucositis in nasopharyngeal carcinoma patients treated with intensity modulated radiotherapy or tomography radiotherapy.

Eligibility criteria:
inclusion criteria: 1.clinical diagnosis of nasopharyngeal carcinoma. 2.7th version american joint committee on cancer (ajcc) stage ii-ivb. 3.age must above 18. 4.performance status must be 0 or 1 according to eastern cooperative oncology group. 5.adequate bone marrow, renal, and hepatic function. exclusion criteria: 1. treatment with palliative intent. 2. previous malignancy. 3. pregnancy or lactation. 4. a history of previous radiotherapy, chemotherapy, or surgery (except diagnostic) to the primary tumor or nodes. 5. any severe coexisting disease.

Keywords: nasopharyngeal carcinoma acute radiation oral mucositis intensity modulated radiotherapy tomography radiotherapy
the use of emergency department by syrian refugees and the increasing cost of health care

Conditions: Emergency

Summary: since the beginning of the syria conflict in march 2011, more than 10 million syrians were forced to leave their homes and sought refuge in neighboring countries.

since the beginning of the syria conflict in march 2011, more than 10 million syrians were forced to leave their homes and sought refuge in neighboring countries (). in the result influx of the thousands of syrian migrants who continue to cross into world, all the world especially the european countries faced with a huge refugee problem. emergency medicine is play key role of being healthcare's safety net, being the last resort for those with no primary healthcare and no alternatives. the aim of this study was to evaluate the use of emergency department by syrian refugees and total and costs of their health care.

Eligibility criteria:
inclusion criteria: * adult syrian patients who visited the emergency department were included in the study. exclusion criteria: * patients below 18 years of age * emergency department returns during same day * patients with missing data in hospital medical record were excluded from the study.

Keywords: refugees syrian cost visit
preoperative antiseptic in newborn circumcision comparison of povidone iodine and hypochlorous acid used

Conditions: Newborn; Infection; Disinfection; Circumcision

Summary: comparison of povidone iodine and hypochlorous acid used as a preoperative antiseptic in newborn circumcision abstract aim: circumcision is one of the most common surgical procedures in all age groups. before the circumcision procedure, asepsis is provided with a surface disinfectant. various methods can be used for this process. povidone iodine, which has been used for years during the transition from traditional circumcision methods to surgical circumcision methods; tissue damage, allergic reactions and increase in pain level. for this reason, the investigators aimed to compare it with hypochlorous acid (crystalin), which is a less toxic and more physiological antiseptic solution. material and method: newborns to be circumcised randomly were divided into two groups as hypochlorosis group and povidone iodine group. at the beginning of the circumcision procedure, a culture was taken in the form of a prepucial swab 1 minute after the cleaning of the local area and the inner surface of the prepuce. then circumcision was performed. culture results and complications were compared.

it is aimed to compare two solutions used for cleaning the operation area in newborn circumcision.it was conducted to compare the antibacterial activity of povidone iodine and hypochlorous.

Eligibility criteria:
inclusion criteria: * male * newborn, exclusion criteria: * hipospadias, * epispadias, * urinary infectious

Keywords: circumcision, wound antibacterial
embryo assessment utilizing timelapse imaging in conjunction with preimplantation genetic testing for aneuploidy with next generation sequencing

Conditions: Infertility, Female; Infertility, Male; Infertility; IVF; Aneuploidy

Summary: the goal of this observational study is to discern if there is a relationship between timelapse imagery of human oocytes/embryos and pgt results. embryos of patients that are undergoing pgt will be placed into a timelapse incubator. the data obtained by the timelapse incubator will be used in conjunction with the pgt data to determine any relationships.

timelapse imagery (tli) is a multifaceted technology being utilized within the in vitro fertilization (ivf) space. with this technology it is possible to have a live, continuous video of embryo development from fertilization to implantation. during this live evaluation multiple datapoints can be extrapolated and used to determine embryo viability. another technology used in the ivf space is preimplantation genetic testing for aneuploidy (pgt-a). with this technology, individual cells from the embryo are removed, amplified, and the chromosomal content of the cells is analyzed by next generation sequencing (ngs)-based technology, allowing the chromosomal content of the embryos to be determined prior to embryo transfer. to date, no one has combined the data from both tools to try to advance the ivf field. gattaca genomics is proposing utilizing the data obtained from tli, in conjunction with the data obtained from pgt-a, to create a computer model that can accurately predict which embryos will lead to a successful outcome during ivf.

Eligibility criteria:
inclusion criteria: * all patients undergoing ivf with pgt exclusion criteria: * patients undergoing ivf and not electing for pgt

Keywords: ivf infertility pgt embryo
a dose determination and safety study of x4p-001 (mavorixafor) in participants with warts, hypogammaglobulinemia, infections, and myelokathexis (whim) syndrome

Conditions: WHIM Syndrome

Summary: this is a phase 2 study with an initial 24-week treatment period and an extension phase. the primary objectives of this phase 2 study are to determine the safety, tolerability, and dose selection of mavorixafor in participants with whim syndrome. participants may continue treatment in an extension phase, if regionally applicable, until mavorixafor becomes available via an alternative mechanism (for example, drug is commercially available, an expanded access program, etc.) or until the study is terminated by the sponsor for any reason.


Eligibility criteria:
inclusion criteria: participants with a clinical diagnosis of whim syndrome must meet all of the following criteria to be eligible for study participation: 1. be at least 18 years of age. 2. has signed the current approved informed consent form. 3. has a genotype-confirmed mutation of chemokine receptor type 4 (cxcr4) consistent with whim syndrome. 4. agree to use effective contraception. 5. be willing and able to comply with this protocol. 6. has confirmed anc less than or equal to (≤) 400/µl or alc ≤650/µl or both. exclusion criteria: participants with any of the following will be excluded from participation in the study: 1. has known systemic hypersensitivity to the mavorixafor drug substance or its inactive ingredients. 2. is pregnant or nursing. 3. has a known history of a positive serology or viral load for human immunodeficiency virus (hiv) or a known history of acquired immunodeficiency syndrome (aids). 4. has, at screening, laboratory tests meeting one or more of the following criteria: * a positive antibody test for hepatitis c virus (hcv), unless documented to have no detectable viral load on 2 independent samples. * a positive test for hepatitis b surface antigen (hbsag). 5. has any medical or personal condition that, in the opinion of the investigator, may potentially compromise the safety or compliance of the participant, or may preclude the participant's successful completion of the clinical study.
integrated alcohol and sexual assault intervention for college men

Conditions: Alcohol Drinking; Sexual Assault

Summary: this research will evaluate a new intervention that integrates evidence-based alcohol intervention strategies and promising sexual assault prevention strategies with the goal of decreasing sexual aggression among men who report heavy drinking; a particularly high risk group. specifically, this study will conduct a randomized controlled pilot trial with college men who report heavy drinking to demonstrate the feasibility and acceptability of the proposed intervention. the main questions the study will answer are: 1) what is the feasibility of the recruitment plans, research design, intervention training methods, and delivery of the program?; and 2) does the intervention, relative to a mindfulness-based control condition, produce reductions in the quantity and frequency of alcohol use, perpetration of sexual aggression, and attitudes associated with sexual aggression over the 2- and 6-month follow-up. follow-up assessments are completed at 2- and 6-months following the program. the intervention is compared to the mindfulness-based control group.


Eligibility criteria:
inclusion criteria: * engaging in binge drinking, defined as 5 or more drinks per day for men on the same occasion by the substance abuse and mental health services administration on two or more occasions in the past month. * engaging in oral, vaginal, or anal sexual intercourse with a female partner one or more times in the past four months exclusion criteria: * displaying symptoms consistent with alcohol use withdrawal * reporting current suicidal or homicidal ideation * meeting criteria consistent with a diagnosis of antisocial personality disorder
propofol versus midazolam+alfentanil for sedation during bronchoscopy: comparison by cutaneous carbon dioxide tension

Conditions: Lung Disease

Summary: although propofol is a popular agent for sedation during flexible bronchoscopy, some clinicians have raised concerns that it may cause greater respiratory drive reduction than more common drugs. however, this factor is difficult to accurately examine with pulse oximetry. the introduction of a novel device that noninvasively measures carbon dioxide (co2) levels can help to resolve this controversy. the aim of this study is to evaluate the safety of conscious sedation with midazolam+alfentanil compared to propofol.

methods: the study group included 115 patients undergoing flexible fiberoptic bronchoscopy(ffb). patients were randomly assigned by a computer before the procedure to receive sedation with midazolam+alfentanil or propofol. local anesthesia was induced by application of 2% lidocaine to the oropharynx. sedation was started with intravenous injection of a bolus of 2-4 mg midazolam and 0.5 mg alfentanil or 20-50 mg propofol. it was maintained with intermittent boluses of 1-3 mg intravenous midazolam or 0.5 mg intravenous alfentanil, according to clinical judgment, or with boluses of 10-20 mg intravenous propofol, administered at short intervals (\~2 minutes) or according to clinical judgment. in all cases, monitoring included continuous electrocardiography, pulse oximetry, and automated noninvasive blood pressure recordings every 5 minutes. in addition, percutaneous carbon dioxide tension (pcco2) was measured with a cutaneous digital sensor (sentec ag, therwil, switzerland) that was placed on the earlobe prior to the procedure. it was removed when the patient left the bronchoscopy suite. during the procedure, all patients received supplemental nasal oxygen at 2-5 l min-1. significant hypoxemia, defined as functional oxygen saturation (spo2) of 90%, was treated initially with jaw support. if it lasted more than few seconds, a naso/oropharyngeal tube was inserted or supplemental oxygen was delivered via face mask at 10 l min-1. the duration of bronchoscopy was calculated from the administration of sedation until the flexible bronchoscope was removed from the tracheobronchial tree. percutaneous carbon dioxide tension, blood oxygenation, heart rate, and blood pressure were compared between the groups. a questionnaire evaluating pain and discomfort by visual analog scale was completed by the patient when awake after the procedure.(\~30 minutes after the end of the procedure

Eligibility criteria:
inclusion criteria: * the study group consisted of patients scheduled for flexible bronchoscopy under local anesthesia with sedation at a tertiary medical center. exclusion criteria: * inability or refusal to provide informed consent, age less than 18 years, bronchoscopy through an artificial airway, and allergy to soya or to one of the sedative drugs.
the embryologist's impact on blastocyst vitrification and thawing

Conditions: Female Infertility

Summary: the goal of this monocentric retrospective observational study is to analyse, for the first time in literature, the role of the embryologist who freezes and thaws the embryos. the primary objective of the study is to understand whether the embryologist who freezes and thaws the embryo influences the cpr (clinical pregnancy rate). secondary objectives, in case of statistically significant influence, are: * evaluate who influences more the cpr, between the embryologist who freezes the embryos and the embryologist who thaws the embryos. * evaluate if the embryologist who freezes and thaws the embryo impacts more than the embryologist or the physician who performs the et. * evaluate whether the embryologists improve their performances, as their experience increases. * evaluate, through an external validation test, whether the model used can also be applied at other pma centres the study will consider all the freezing (vitrifications) and thawing procedures, performed at humanitas fertility center between january 2019 and june 2023. the study will include the transfers of single blastocysts, cryopreserved at humanitas fertility center. on the other hand, the blastocysts transferred from other centres and the donor blastocysts will be excluded from the study, as well as multiple blastocysts transfers and the lp cycles. the embryologist's experience will be assessed in terms of number of previous cryopreservation (vitrification) and thawing procedures. we will include in the study all the embryologists who performed at least 50 freezing and thawing. for the evaluation of the study objectives, data will be gathered using a specific internal web-based database. the final model will be created by analysing the humanitas fertility center dataset and validated using datasets extrapolated from similar population from the san raffaele hospital infertility centre


Eligibility criteria:
inclusion criteria: the study database will include all the patients who performed a single cryopreserved blastocyst transfer, between january 2019 and june 2023, including also pgta and repeated art cycles. the embryologist's experience will be assessed in terms of number of previous cryopreservation (vitrification) and thawing procedures. we will include in the study all the embryologists who performed at least 50 freezing and thawing. exclusion criteria: the blastocysts transferred from other centres and the donor blastocysts will be excluded from the study, as well as multiple blastocysts transfers and the lp cycles, to reduce the risk of selection bias or physician-embryologist couple bias. the embryologists who performed less than 50 freezing and thawing will be excluded from the study. similarly, the first 50 procedures performed by each embryologist will not be counted in the data set.
volume increase versus supplemental 4% articaine buccal infiltration on mepivacaine inferior alveolar nerve block success

Conditions: Symptomatic Irreversible Pulpitis

Summary: to assess the anesthetic success of inferior alveolar nerve block (ianb), intraoperative pain intensity and need for supplemental anesthesia on administration of 1.8ml or 3.6ml 2% mepivacaine ianb, or 1.8ml 2% mepivacaine ianb plus 1.8ml 4% articaine buccal infiltration (bi) in mandibular molars with symptomatic irreversible pulpitis.

patients with moderate-to-severe preoperative pain related to mandibular molars with symptomatic irreversible pulpitis will be included. patients receive 1.8 ml, 3.6 ml 2% mepivacaine ianb, or 1.8ml 2% mepivacaine ianb plus 1.8ml 4% articaine bi. anesthetic success of inferior alveolar nerve block, intraoperative pain intensity and need for supplemental anesthesia will be assessed during treatment.

Eligibility criteria:
inclusion criteria: 1. patients in good health (asa class i, ii). 2. age between 18-60 years old. 3. males or females. 4. mandibular molar teeth diagnosed with symptomatic irreversible pulpitis. 5. patients who can understand nrs scale and sign the informed consent. exclusion criteria: 1. patients who had used any type of analgesic medication during the preceding 8 hours before the treatment. 2. pregnant or nursing females. 3. patients with a contraindication for the use of mepivacaine, articaine or any used drug or material.
short versus long cephalomedullary nailing of pertrochanteric hip fractures: a randomized prospective study

Conditions: Pertrochanteric Hip Fracture

Summary: is there a functional outcome difference when treating pertrochanteric fractures with a short or long cephalomedullary nail?


Eligibility criteria:
inclusion criteria * ao/ota fracture classification 31(a-b) (1-3). * age greater than 18 years old. exclusion criteria -less than 18 years old.
pharmacokinetics, acceptability and safety of famciclovir in infants (1 month to less than 12 months) with herpes simplex infection

Conditions: Herpes Simplex

Summary: this study will evaluate the acceptability and safety of famciclovir in infants with herpes simplex infection


Eligibility criteria:
inclusion criteria: * male and female patients from 1 month up to 1 year of age with herpes simplex infection exclusion criteria: * patients with gestational age less than 32 weeks. patients unable to swallow. patients with history of malabsorption or previous gastrointestinal surgery. other protocol-defined inclusion/exclusion criteria may apply.

Keywords: infants, herpes simplex infection
a study of ultra-fraction radiotherapy bridging cart in r/r dlbcl

Conditions: Diffuse Large B Cell Lymphoma; CAR-T; Radiotherapy; Bridging Therapy

Summary: this is a single-arm single center study to prospectively evaluate the safety and efficacy of ultra-fraction radiotherapy bridging car-t therapy in relapsed/refractory diffuse large b cell lymphoma


Eligibility criteria:
inclusion criteria: 1. over than 18 years old 2. histologically confirmed dlbcl(by central pathology review before enrolment) 3. relapsed or refractory disease after ≥2 lines of chemotherapy including rituximab and anthracycline and either having failed autologous hematopoietic stem cell transplantation (asct), or being ineligible for or not consenting to asct 4. measurable disease at time of enrollment (the maximum diameter of cross section ≥1.5cm) 5. life expectancy ≥12 weeks 6. able to receive radiotherapy evaluated by specialist exclusion criteria: 1. prior radiation therapy within 1 year of infusion 2. pregnant or nursing (lactating) women 3. uncontrolled acute life threatening bacterial, viral or fungal infection (e.g. blood culture positive ≤ 72 hours prior to infusion) 4. previous solid tumor within 3 years, previous or concurrent hematological malignancy 5. severe organ dysfunction: left ventricle ejection fraction (lvef) \ 3 uln 6. hiv positive patients, active replication of or prior infection with hepatitis b or active hepatitis c( hcv rna positive ); 7. other conditions that the investigator may exclude due to risks or other possibilities
evaluation of novel lung function parameters in patients with bronchial asthma

Conditions: Bronchial Asthma; Pulmonary Healthy Controls

Summary: current guideline-based criteria defining bronchial asthma do not always meet the challenges set by the complex pathophysiology of the disease. the investigators therefore aimed to evaluate novel or not widely used functional diagnostic approaches for the detection and therapeutic monitoring of patients with asthma.


Eligibility criteria:
inclusion criteria: * known or suspected bronchial asthma * known or suspected obstructive ventilation disorder * pulmonary healthy controls exclusion criteria: * pregnancy * inability to participate
symptom management after breast cancer surgery

Conditions: Neuropathic Pain; Postmastectomy Pain

Summary: this trial is part of a larger, longitudinal study of symptoms that occur in the breast surgical scar area and/or ipsilateral arm following breast cancer surgery. women who develop pain in the breast scar area or ipsilateral arm will be randomized to a placebo patch or a lidocaine patch that they will wear on a daily basis for 12 weeks. we hypothesize that women who wear the lidocaine patch will report a decrease in pain and decreased interference with function compared to women who wear the placebo patch.


Eligibility criteria:
inclusion criteria: * adult women \>18 years who develop neuropathic pain in the breast scar area and/or ipsilateral arm following breast cancer surgery * has a healed incision(s) * has no recurrent disease in the painful area * is able to read, write and understand english exclusion criteria: * presence of another type of pain that is more severe than the neuropathic pain * use of an opioid analgesic of greater than 60 mg codeine/day * is actively trying to become pregnant * has a medical contraindication to the use of lidocaine * has an allergy to lidocaine * is taking a coanalgesic for neuropathic pain.

Keywords: breast cancer neuropathic pain topical lidocaine postmastectomy pain breast symptoms breast pain