Kornimate/medical-research-clean huggingface dataset:
cytodiagnosis of basal cell carcinoma and actinic keratosis using papanicolaou and may-grunwald-giemsa stained tissue smear

Conditions: Carcinoma, Basal Cell; Porokeratosis, Disseminated Superficial Actinic

Summary: the purpose of this study is to compare and evaluate the diagnostic performance of scrape cytology using two different cytological staining techniques, and to evaluate additional touch imprint cytology with that of histopathology of superficial basal cell carcinoma and actinic keratosis.


Eligibility criteria:
inclusion criteria: histologically verified basal call carcinoma and actinic keratosis exclusion criteria: morphea form of basal cell carcinoma. pigmented form of basal cell carcinoma.

Keywords: cytodiagnosis skin scrape touch imprint papanicolaou may-grunvald-giemsa
effects of an online hearing support for first-time hearing aid users

Conditions: Hearing Loss; Hearing Impairment; Hearing Disorders; Hearing Disability; Ear Diseases; Sensation Disorders; Otorhinolaryngologic Diseases

Summary: the goal of this randomised controlled trial is to test a online hearing support for first-time hearing aid users. the main questions it aims to answer are short- and long-term effects on the emotional and social consequences of hearing loss that the participants experience, use of communications strategies, experienced listening in complex sound environments and perceived effectiveness and satisfaction with hearing aids.


Eligibility criteria:
inclusion criteria: * adults \> 20 years of age that are eligible for hearing aids * access to a computer, tablet and/or smartphone with internet * access to a swedish bankid or equivalent exclusion criteria: * inability to read and understand swedish
identification of marker of primary or acquired resistance to anti tumorous treatment

Conditions: Melanoma; Non Small Cell Lung Cancer; Small Cell Lung Cancer

Summary: lung cancer and melanoma relapsed frequently whereas its very sensitive to treatment such as chemotherapy or radiotherapy. the purpose of this study is to have a better understanding of why those patients are relapsing using next generation sequencing to identify rare mutations and assessed their predictive value.


Eligibility criteria:
inclusion criteria: 1. cytological or histological diagnosis of sclc, nsclc or melanoma 2. patients age \>/= 18 years old 3. indication of treatment using platinum salts for lung cancer except for patient with nsclc treated by surgery for whom platinum salts is not indicated 4. if a biopsy is proposed, lesion lust be easily accessible 5. signed informed consent exclusion criteria: 1. patients unable to follow the protocol 2. consent refusal
safety and immune enhancing effects of acute dosing of cold-fx in healthy adults

Conditions: Healthy

Summary: subjects will be asked to participate in a four day research study of the immune system effects and safety of short-term acute dosing of cold-fx. the purpose of the study is to determine the effects of acute dosing of cold-fx for 3 days on the immune system compared to a placebo (dummy pill). safety of the acute dosing will be determined through various blood tests carried out during the study.

eligible volunteers from hackensack university medical centre will be randomly assigned to either the treatment or placebo group with equal numbers in each group. the treatment will consist of taking three capsules of cvt-e002 (600mg) or placebo three times daily on day 1, two capsules of cvt-e002 (400mg) or placebo three times daily on day 2 and one capsule of cvt-e002 (200mg) or placebo three times daily on day 3. a fasting blood sample will be collected on all 4 days of study participation. immunological assays and blood chemisty safety tests will be performed on the samples. serum samples will also be collected and stored until futher analysis for various cytokines. any adverse events experienced during this study will be documented.

Eligibility criteria:
inclusion criteria: * general good health * willing to adhere to the requirements of the protocol, including availability for follow-up visits * willing and able to sign written informed consent exclusion criteria: * individuals with known hiv infection * individuals with malignancy * individuals with a history or symptoms of unstable cardiovascular disease * individuals with renal abnormalities * individuals having a history or symptoms of pulmonary disease * individuals having acute or active chronic liver disease * individuals having neurologic or psychiatric disease * individuals having active tuberculosis * individuals having multiple sclerosis * individuals having bleeding disorders * individuals with planned surgery over the course of the trial or having had major surgery in the past 6 mo. * individuals with a history of alcohol/drug abuse * pregnant and lactating women * individuals on prescribed medication with the exception of oral contraceptives * individuals with crohn's disease, lupus, rheumatoid arthritis, colitis or any other auto-immune disease * individuals using natural health products or dietary supplements for 2 weeks prior and during the trial * individuals having allergies to ginseng or to any known component of the drug product or placebo * smokers (smoking \> 10 cigarettes/day) * alcoholics (drinking \> 10 drinks/week)

Keywords: nk cells cytokines lymphocytes immunoglobulins th1 response
immediate effects of whole body vibration on hemodynamic response and fatigue in normotensive people with obesity

Conditions: Obesity; Blood Pressure; Whole Body Vibration; Exercise

Summary: whole body vibration therapy (wbvt) has been identified as a useful tool to increase peripheral blood flow. the present study aimed at how dynamic exercises with wbvt immediate effect on hemodynamic response and fatigue parameters in patients with obesity.


Eligibility criteria:
inclusion criteria: * individuals between age 18-65 with body mass index (bmi) of \>29.9 kg/m2 exclusion criteria: * unstable hypertensive patients * history of cardiovascular, neurologic, or orthopedic diseases, * presence of knee prosthesis, hip replacement * chronic inflammatory disease, * anti-inflammatory treatment * cognitive impairments * pregnancy.
efficacy and safety of diclofenac diethylamine 2.32% gel in patients with acute ankle sprain

Conditions: Ankle Sprain

Summary: this study will evaluate the efficacy of diclofenac diethylamine 2.32% gel in the treatment of acute ankle sprain.


Eligibility criteria:
inclusion criteria: * acute sprain of the ankle * injury within past 48 hours. exclusion criteria: * pain medication taken since the injury * pain or instability in the same ankle due to previous ankle sprain or any other trauma. * ankle sprain due to a known disease affecting the ligaments other protocol-defined inclusion/exclusion criteria may apply

Keywords: ankle, sprain, diclofenac diethylamine
modic changes and associated features in southern european chronic low back pain patients

Conditions: Low Back Pain

Summary: to assess: a) the prevalence of modic changes and other findings on lumbar magnetic resonance imaging (mri), among spanish adult chronic lbp patients, b) patient characteristics and radiological findings associated with modic changes.

ten radiologists from six hospitals across six cities in spain, consecutively recruited 487 adult patients (263 women and 224 men) in whom lumbar mri had been prescribed for low back pain lasting ≥ 3 months. patients' characteristics and imaging findings were assessed through previously validated instruments. a multivariate logistic regression model was developed to assess the features associated with modic changes. outcome measures were: gender, age, body mass index (bmi), life time smoking exposure, degree of physical activity, and image features (disk degeneration, type and extension of modic changes, disk contour, annular tears, spinal stenosis and spondylolisthesis).

Eligibility criteria:
inclusion criteria: * patients between 35 and 50 years of age having a diagnosis of chronic low back pain (of 3 or more months' duration, and including sciatica and lumbar cytalgia), who get a prescription for an mri. exclusion criteria: * racial characteristics suggesting a non-spanish origin; central nervous system pathology (with or without treatment); * diagnosis or suspicion of systemic disease (inflammatory disease such as rheumatoid arthritis, or infections).

Keywords: modic changes chronic low back pain magnetic resonance imaging (mri) vertebrae intervertebral disc
effects of dry needling on autonomic nervous system and nociceptive pain processing in neck pain

Conditions: Neck Pain

Summary: pain in the neck is a musculoskeletal disorder that affects many individuals. dry needling has shown an effective technique for the treatment of shoulder and neck disorders. the mechanisms of action of the dry needling are not well-known. this study aims to evaluate the effects of dry needling in the upper trapezius on the autonomic nervous system and nociceptive pain processing in patients with non-specific neck pain. hypothesis: dry needling applied in the upper trapezius in patients with non-specific neck pain produced greater activation of the autonomic nervous system and nociceptive pain processing than sham dry needling.

a randomized, double-blind, placebo-controlled clinical trial, using dry needling (dn). dn is a technique to treat musculoskeletal pain and physical impairment that consists of introducing needling filaments in the muscle trigger points. study aims: aim #1: the primary aim of the study is to compare the effect (during the technique and five minutes after intervention) of a single session of dn on autonomic nervous system as measured by skin conductance in patients with non-specific neck pain with random assignment to two treatments: dn or sham dn aim #2: the secondary aim of the study is to compare the immediate effect on pain sensitivity as measured by pressure pain threshold, activation of descending inhibition pain pathways as measured by temporal summation and conditioned pain modulation in patients with non-specific neck pain with random assignment to two treatments: dn and sham dn. aim #3: the secondary aim of the study is to compare the immediate effect on intensity of pain as numeric pain rating scale (nprs), relating pain disability (northwick park neck pain questionnaire), fear-avoidance of movement (tampa scale for kinesiophobia) and catastrophizing (pain catastrophizing scale) aim #4: the secondary aim of the study is to correlate effects between clinical and other variables.

Eligibility criteria:
inclusion criteria: 1. pain in the neck area, including the upper trapezius muscle; 2. at least one active trp (i.e., trp which referred pain is able to reproduce the patient symptoms in the upper trapezius) 3. ability to read and understand spanish 4. self-reported intensity of pain rating on the 0-10 nprs for the neck-shoulder region is 3 or greater 5. ability to understand, write, and speak spanish fluently exclusion criteria: 1. neurological symptoms or signs compatible with cervical radiculopathy or myelopathy 2. cervical trauma 3. systemic diseases 4. pregnancy 5. psychiatric problems 6. fear of needles.

Keywords: neck ache cervicalgia cervicodynia neckache cervical pain dry needling
metabolic abnormalities and intestinal microecology in patients with chronic disorders of consciousness

Conditions: Disorder of Consciousness

Summary: following severe traumatic brain injury, patients may remain unconscious for many years. it is the intestinal microbiome and metabolomics analysis comparing differentially intestinal microflora and metabolites between patients with chronic disorder of consciousness and controls so far. the investigators have mature data analysis technology. the obtained results provide new insight into understanding the molecular mechanisms underlying the chronic disorder of consciousness

objective:to determine differences in metabolic profiles and intestinal microbial abundance among healthy human individuals and patients in a vegetative state (vs) and minimally conscious state (mcs) and to identify metabolites in human plasma that can accurately distinguish vs patients from mcs patients. method: plasma samples and fecal sample were obtained from patients with chronic disorder of consciousness, and healthy volunteers. a comprehensive metabolic profile was obtained with targeted metabolomics analysis and untargeted and targeted lipidomics analysis, as well as intestinal microbial abundance from 16s rrna gene amplicon sequencing.

Eligibility criteria:
inclusion criteria: 1. patients ages 18 to 80 years old; 2. patients had a history of severe traumatic brain injury (tbi); 3. patients had awakened from a coma (indicating preserved sleep-wake cycles), including vegetative state and minimally consciousness state; 4. patients stay unconscious for more than 1 month. exclusion criteria: 1. patients with disorders of consciousness caused by other inducements; 2. other neurological or psychiatric conditions prior to the current brain injury; 3. persistent seizure-like activity, inhibition or seizure inhibition; 4. the patients had taken a sedative barbiturate neuroleptics or antidepressants within one month; 5. the clinical state is unstable, and there are signs of spontaneous recovery or deterioration within 1 week; 6. the patients have taken gastrointestinal motility drugs or other drugs affecting gastrointestinal motility in the past month; 7. had taken antibiotics and probiotics in the past month; 8. patients with intestinal diseases such as colon cancer, ulcerative colitis or crohn's disease; 9. patients with acute infectious diseases or liver dysfunction

Keywords: disorder of consciousness microbiome metabolomics
regent china post-market clinical follow-up study

Conditions: Valvular Heart Disease; Aortic Valve Disease

Summary: regent china post-market clinical follow-up (rc-pmcf): this clinical study is to confirm the safety and performance of abbott's regent mhv for replacement of native or prosthetic aortic valves in a chinese population.

the purpose of the rc-pmcf study is to meet the post-market clinical followup (pmcf) requirements of the national medical products administration (nmpa). the primary objective of this clinical study is to confirm the safety and performance of abbott's regent mhv for replacement of native or prosthetic aortic valves in a chinese population. this is a prospective, observational, multi-center study of subjects clinically indicated for implantation of an abbott medical's regent valve.

Eligibility criteria:
inclusion criteria: 1. patient is eligible to be implanted with regent to replace a native or prosthetic aortic valve per regent's ifu. 2. subject will be \>18 years of age at time of being consented. 3. subject, provides written informed consent prior to any clinical investigation-specific procedure. exclusion criteria: 1. subject is unable to tolerate anticoagulation therapy. 2. subject has active endocarditis. 3. subject is currently participating in another clinical investigation which may interfere with the effectiveness of anticoagulation therapy. 4. pregnant or nursing subjects and those who plan pregnancy during the clinical investigation follow-up period. women of child-bearing potential must have a documented negative pregnancy test within one week prior to enrollment. 5. subject has anomalous anatomy or medical, surgical, psychological or social history or conditions that, in the investigator's opinion, could limit the subject's ability to participate in the clinical investigation or to comply with follow-up requirements of the clinical investigation results. 6. subject is unable to read or write or has a mental illness or disability that impairs their ability to provide written informed consent. 7. subject's life expectancy is less than 1 year in the opinion of the investigator.
whipples resection in octogenarians

Conditions: Pancreatic Cancer

Summary: whipples resection is an operation that has a burden of high morbidity and mortality. it is performed for a variety of disorders of the pancreas, duodenum and ampulla. the most common indication is pancreatic ductal adenocarcinoma which has a poor long term outcome even when curative surgery has been performed. short and long term outcomes however, have improved recently and the indications for curative resection have been increasingly extended, including operating on those that previously may have been considered too old to benefit from curative resection. little is known about the benefit of performing this procedure in the oldest patients. performing whipples resection in patients over the age of 70 has been reported and has been shown to result in satisfactory perioperative results with comparable long term outcomes to those under 70. however the benefit of performing the same procedure in the over 80 age group is less well reported and consistently presents a challenging decision for the clinician.

whipples resection is an operation that has a burden of high morbidity and mortality. it is performed for a variety of disorders of the pancreas, duodenum and ampulla. the most common indication is pancreatic ductal adenocarcinoma which has a poor long term outcome even when curative surgery has been performed. short and long term outcomes however, have improved recently and the indications for curative resection have been increasingly extended, including operating on those that previously may have been considered too old to benefit from curative resection. little is known about the benefit of performing this procedure in the oldest patients. performing whipples resection in patients over the age of 70 has been reported and has been shown to result in satisfactory perioperative results with comparable long term outcomes to those under 70. however the benefit of performing the same procedure in the over 80 age group is less well reported and consistently presents a challenging decision for the clinician. this study therefore aims to assess the short and long term outcomes of patients undergoing whipples pd in the over 80 age group in lothian. this will be combined with data from all the other units in scotland that perform whipples resection (dundee, glasgow and aberdeen) the primary outcome will be overall and disease free survival. participants will be identified by using procedure specific codes to identify those patients who underwent whipples pancreaticoduodenectomy from the orsos prospectively collated theatre record database. the other centres in scotland will identify their subjects via their own methodology.

Eligibility criteria:
inclusion criteria: * all patients undergoing whipples pd from 1998-2018 in scotland exclusion criteria: * incorrectly coded as whipples resection * underwent non curative bypass procedures.
diabetes cohort in french amazonia

Conditions: Diabetes Mellitus; Adults

Summary: codiam aims to collect clinical, biological and social data of diabetic patients in french guiana.

diabetes is a very common disease in french guiana. this disease is caused by the body's inability to metabolise sugar properly. a diet and treatment with tablets are enough for some patients, while others may need insulin injections. in the long term, high blood sugar levels may cause problems to the small and large blood vessels in the body. this is complicated by nerve, renal and retinal damage, as well as increased risks of cardiac and vascular events (such as strokes or heart attacks.) it appears that diabetes is more common and more severe in french guiana than in other parts of france. it seems that the types of diabetes found here are more variable than those found in france, and that patients tend to be diagnosed at a later stage. we would this like to better understand diabetes and its evolution in french guiana. this research is aimed at diabetic patients and it is being carried out in the andrée rosemon hospital centre, the ouest guyanais hospital centre as well as in other primary healthcare centres. at some point in the future, some private health centres may also invite their patients to take part in this study.

Eligibility criteria:
inclusion criteria: * patients with diabetes * at least 18 years old exclusion criteria: * less than 18 years old * patients under legal guardianship * patients' refusal to participate * patients living outside french guiana

Keywords: diabete french guiana
acute effects of intradialytic exercise on cardiovascular function in hemodialysis patients

Conditions: Kidney Failure

Summary: the purpose of this study is to examine the effect of cycling at mild to moderate intensity during hemodialysis treatment on cardiovascular function in a crossover design.

patients with kidney failure requiring hemodialysis (hd) treatment die at excessively high rates, despite advances in hd techniques and pharmacological therapies. this indicates additional therapeutic strategies are needed. intradialytic exercise (idex, exercise during hd treatment) represents a low-cost, easy to administer treatment strategy that could potentially improve cardiovascular function, physical function and quality of life. however, nephrologists rarely counsel their patients to increase their physical activity levels or to exercise during hd treatment, in part due to a lack of understanding of idex knowledge. providing more robust evidence for the safety and effectiveness of idex, as well as evaluating the impact of exercising early vs late in the treatment, could help improve adoption of exercise training as a standard practice in hd clinics. therefore, investigators plan to examine the impact of idex and its timing during treatment (1st vs 3rd hour) on blood pressure and adverse symptoms in hd patients. the proposed study also includes various cardiovascular measures to allow deeper mechanistic understanding of cardiovascular physiology with idex. such understanding will significantly advance the field and lead to improved therapeutic approaches, including exercise training, which may help mediate the deleterious effects of renal failure.

Eligibility criteria:
inclusion criteria: * receiving hemodialysis treatment three times per week, on hemodialysis for greater than three months, receive medical clearance from a nephrologists exclusion criteria: * patients with established contraindications to exercise including lower-limb amputation, advanced chronic obstructive pulmonary disease and decompensated chronic heart failure.

Keywords: intradialytic exercise cardiac and arterial function