Kornimate/medical-research-clean huggingface dataset:
dissemination of the "choisir de maigrir?" program

Conditions: Obesity

Summary: the québec government launched in october 2006 an action plan (pag) to reduce the prevalence of overweight and obesity among young people and adults by 2012. one of the five priorities of the pag is to improve health services for individuals with weight-related issues. the development and implementation of sustainable weight-control strategies however remains a challenge, since weight loss is often regained by the majority of individuals over time. "health-at-every-size" (haes) interventions, which are mainly focusing on health rather that weight, have been proposed as an interesting alternative for individuals, mainly women, who are struggling with weight-related issues. based on the haes, "choisir de maigrir?" (cdm?) program has been clearly identified by the pag as one of the actions for improving health services and quebec's government has already started a massive dissemination of the cdm? program in csss of québec. in that context, it becomes imperative to rapidly assess the effectiveness and readiness of the program for a broad dissemination. the present research proposal falls directly within the scope of the pag recommendation and the investigators general objective is to develop a population-based understanding of the effectiveness of the cdm? program in quebec's csss by documenting the effects of the program on women's health in a natural setting.

the impact of "cdm?" will be assessed with each csss at three time points: at baseline (t=1), at the end of the intervention period (t=2), and at 1-y post-intervention (t=3). while data collection instructions and assessment materials will be provided by the research team, administration of the cdm? program will be totally under the responsibility of each csss, so that the program will occur outside of the research team control. validated questionnaires will be used to assess nutritional profile, physical activity level, and psychosocial variables among the participants (n=168). weight, height and waist circumference will also be measured for each participant. in order to ensure that our results are not due to the effect of time, women on a waiting list for cdm? program, will be recruited (n=84) for the short-term effect. all these data will be treated using sophisticated analyses strategies.

Eligibility criteria:
inclusion criteria: * women * 18 years old and over * seeking help for weight-related problems exclusion criteria: * considering the natural setting of the present study and the fact that the program is occurring outside of the applicants' control, no stringent exclusion criteria will be determined.

Keywords: health-at-every-size intervention
bedside ultrasound measurement of the inferior vena cava correlates to central venous pressure

Conditions: Shock; Hypovolemia; Hypervolemia

Summary: this study proposes to examine the correlation of central venous pressure to measures of the diameter of the inferior vena cava as determined by bedside ultrasonography.

central venous pressure (cvp) is a key physiologic estimate of preload, which in turn helps define the vascular fluid status. it is a particularly important parameter to measure in critically ill and injured patients who may require resuscitation. unfortunately, measurement of the cvp requires invasive central venous catheters which can be difficult or time-consuming to insert. a non-invasive means of inferring the cvp would provide clinicians with an alternative. preliminary data suggests that the diameter of the vena cava may reflect the cvp. ultrasonography can provide reliable measures of internal body structures including the vena cava, and therefore may be useful in this regard. collecting simultaneous values of vena cava diameter and cvps will allow for the identification and quantification of correlation.

Eligibility criteria:
inclusion criteria: * cvp or right heart catheter that is already in place and functioning properly exclusion criteria: * supine position or placement of ultrasound probe on abdomen is contraindicated.

Keywords: ultrasonography central venous pressure noninvasive monitoring shock resuscitation
pci suite: road map fusion imaging in coronary diagnostics and therapy

Conditions: Coronary Disease

Summary: the pci suite is developed by philips medical systems, a philips healthcare company. the proposed pci suite is a new software package which can be used during coronary interventions. the software package includes two sub-packages, known as stentboost and cardiac roadmapping. the patient will undergo standard of care medical treatment for his or her cardiac condition. during the procedure, the physician may make angiograms for diagnosis and as reference for device navigation as part of the standard care. these angiograms will be automatically processed in pci suite and displayed on fluoroscopy for navigation support. in case a balloon catheter is inserted into the coronary arteries, the physician may take cine images as part of the standard care. these images can be automatically enhanced in pci suite. the primary objective of this prospective, mono-center, randomized clinical trial is to evaluate the amount of contrast medium used during percutaneous coronary intervention.


Eligibility criteria:
inclusion criteria: * hemodynamically relevant type a or b lesion exclusion criteria: * hemodynamically relevant type c lesion * nstemi/stemi * declined to participate
epidural pca on pain relief after l-spine surgery

Conditions: Pain, Postoperative; Lumbar Spine Degeneration; Analgesia, Patient-Controlled; Epidural Anesthesia

Summary: this study aimed to evaluate the effect of epidural patient-controlled analgesia (pca) on postoperative pain relief after lumbar spine surgeries. the eligible patients received two types of postoperative pain management: pca and standard pain treatment. comparisons between the two groups were made in terms of postoperative pain level.

this study included patients who underwent lumbar spine surgeries for degenerative spinal disease. the eligible patients were divided into two groups, the pca group and the control group, for two types of postoperative pain management. the patients in the pca group received 72-hour epidural pca. the pca catheter was inserted by the surgeon prior to wound closure in the lumbar spine surgery. the pca catheter was maintained until 72 hours after the surgery and was removed at the postoperative day 4. the control group received postoperative standard pain treatment, including oral acetaminophen and muscle relaxants. no non-steroidal anti-inflammatory drugs were given in this study. all patients were provided the option to request intramuscular morphine injection (0.5 mg of morphine) for additional pain control, with a minimum interval of 6 hours between doses. pain assessment was conducted using a visual analogue scale on the first four postoperative days and on the day of discharge. at the postoperative day 4, pain assessment was performed before the pca removal. the level of pain and the number of morphine injections were compared between the two groups.

Eligibility criteria:
inclusion criteria: 1. age greater than 60 years 2. having lumbar spine surgeries for degenerative spinal stenosis, spondylolisthesis, herniated intervertebral disc, or osteoporotic spinal fracture with spinal stenosis exclusion criteria: 1. spinal infection (e.g., tuberculosis, epidural abscess, and vertebral body osteomyelitis 2. iatrogenic cerebrospinal fluid leakage or dura tear during surgery 3. spinal tumor or spinal metastasis 4. having minimally invasive procedures with the bilateral paramedian approach
extracorporeal photopheresis after liver transplant

Conditions: Hepatic Insufficiency

Summary: the purpose of this study is to determine the safety of photopheresis for prophylaxis of allograft rejection in patients who are being withdrawal immunosuppression after liver transplantation.

the photopheresis (ecp) is a therapeutic approach based on the biological effect of ultraviolet light a on mononuclear cells collected by apheresis, and reinfused into the patient.

Eligibility criteria:
inclusion criteria: * liver transplantation 2 years ago * \>18 years * treatment with immunosuppression (cyclosporine or tacrolimus) * normal hepatic function during last year * no acute or chronic rejection * to have some secondary effect because of immunosuppressors * previous disease: alcoholic liver cirrhosis with or without hepatocarcinoma, metabolic disease, amyloid polyneuropathy, hepatitis,cryptogenic cirrhosis and non autoimmune causes * signing consent informed form exclusion criteria: * additional liver transplantation * hypersensitivity to methoxsalen * patients with melanoma ,cutaneous carcinoma * patients with aphakia * patients treated with oxsoralen * pregnant women, lactating women or fertile adults that they don´t use a effective anticonception method * involved in other assay.

Keywords: liver transplantation immunosuppression photopheresis extracorporeal
safety and tolerability of hepastem in patients with cirrhotic and pre-cirrhotic nash patients

Conditions: NASH - Nonalcoholic Steatohepatitis

Summary: multicenter, open-label, safety and tolerability study of ascending doses of hepastem in patients with cirrhotic and pre-cirrhotic non-alcoholic steato-hepatitis (nash) to determine the safety and tolerability of ascending single and repeated doses of hepastem administered to patients with cirrhotic and pre-cirrhotic non-alcoholic steato-hepatitis (nash)


Eligibility criteria:
main inclusion criteria: * able and willing to provide written informed consent and comply with the requirements of this study protocol * age 18 to 70-years old, inclusive * proven diagnosis of nash based on histological evidence from biopsy performed within 6 months for f3 patients and within 2 years for f4 patients prior to screening if no biopsy is available within these time windows, a biopsy should be performed at screening nb: for f4 patients for whom the biopsy cannot confirm the diagnosis of nash, any other causes of underlying liver diseases should be excluded main exclusion criteria: * alcoholic liver disease or alcohol consumption exceeding the daily intake of 140g/w (two doses) for women and of 210g/w (three doses) for men * other causes of liver disease including, but not limited to, alcoholic liver disease, active hepatitis b (hbsag+), hepatitis c (pcr positive), autoimmune disorders, drug-induced hepatotoxicity, wilson disease, hemochromatosis, and alpha-1-antitryspin deficiency based on medical history and/ or clinical and biological assessment * recent recurrent or ongoing thrombotic or bleeding events within 3 months prior the screening * patients considered at persistent risk of thrombosis or bleeding at the time of screening * patients with high risk of gastro intestinal bleeding at time of the screening. * cerebrovascular, myocardial, or limb arterial thrombotic event within 12 months prior to the screening and/or not considered stabilized by the investigator * bariatric surgery within 1 year prior to the screening * coagulation disturbances defined as (drolz et al. 2016, nadim et al. 2016, stravitz et al. 2018, green et al. 2018): fibrinogen at \< 80 mg/dl and/or platelets at \< 40 x 10³/mm3 * severe hepatic encephalopathy (defined by west haven grade \> 2) * acute decompensation of cirrhosis with chronic liver failure consortium acute decompensation (clif-c ad) score \> 60 * acute on chronic liver failure (aclf) grade 1, 2 ,3 * meld score \> 20 * child pugh score ≥ c

Keywords: nash
progression of disease in patients newly diagnosed with glaucoma and glaucoma suspects participating in the gate study

Conditions: Glaucoma

Summary: the purpose of this study is to measure how many patients develop worsening glaucoma in the early years (2-4 years) of routine monitoring in hospital eye services. we will study a group of patients who were initially diagnosed as having glaucoma, or having high pressure in the eye (ocular hypertension) or having been diagnosed as a glaucoma suspect.

in the uk, patients with possible signs of glaucoma or ocular hypertension (oht) are usually picked up at a routine sight test at their optician or general practitioner. these patients are usually diagnosed in secondary care hospital eye services by an ophthalmologist. in addition to those diagnosed with oht and glaucoma there are a large group of patients who have ocular characteristics similar to those found in glaucoma patients, but could also represent variations in normality. in this group, 'glaucoma suspects', monitoring in secondary care for a number of years is recommended in order to establish whether they have glaucoma or if after several years of monitoring there are no clear signs of glaucoma the patient may be discharged. in our study we will conduct a case-note review of a well-defined cohort of patients who were first identified through a diagnostic accuracy study (the gate study). this includes (1) patients with oht, (2) patients identified as glaucoma suspects and (3) patients diagnosed with glaucoma. we will investigate how many patients have experience worsening disease and how many patients have been discharged due to a low risk of glaucoma. we will also investigate the relationship between baseline demographic characteristics and characteristics of the eye and progression of disease.

Eligibility criteria:
eligibility for patients to be recruited into the gate study was as follows: inclusion criteria: - adults referred from community optometrists or general practitioner to hospital eye services with suspected glaucoma, including those with ocular hypertension. exclusion criteria: * patients referred to hospital eye services because of other ocular disease; * patients \< 18 years old; * patients who cannot give informed consent, * patients already diagnosed with glaucoma. this study cohort is further defined from the gate population as selection criteria: * gate study patients with a baseline diagnosis of oht, glaucoma suspect or glaucoma (any mechanism); * remaining in secondary care monitoring after first visit; * recruited at aberdeen royal infirmary or hinchingbrooke hospital nhs trust.

Keywords: glaucoma suspect ocular hypertension progression
taste supra-thresholds among a sample of depressed egyptian adult under anti-depressants therapy

Conditions: Taste Disorders

Summary: determine the taste intensity at supra-threshold among a sample of depressed egyptian adults (age from 20 to 50 years old) under anti-depressants therapy ( for at least 3 months) using filter paper disc(fpd) method using a psychophysical method through a scoring system.

peco * p population: depressed egyptian adults under anti-depressants therapy * e1 exposure 1: tricyclic antidepressants (imipramine, amitriptyline, clomipramine hcl) * e2 exposure 2: selective serotonin re-uptake inhibitors antidepressants ( fluoxetine, fluvoxamine, sertraline, citalopram, paroxetine) * c control (non exposure) : non-pharmacological treatment ( psychotherapy) * o outcome: determine the taste intensity at supra-threshold among these patients using a psychophysical method through a scoring system

Eligibility criteria:
inclusion criteria: * depressed egyptian adults under antidepressants therapy for at least 3 months/non-pharmacological treatment( psychotherapy) • age from 20 to 50 years old exclusion criteria: * antipsychotics * hypnotics * anticonvulsants * ages other than the mentioned • olfactory dysfunction * chemosensory dysfunction
hepquant to predict hepatic encephalopathy after tips

Conditions: Hepatic Encephalopathy; Cirrhosis, Liver

Summary: a pilot study to determine if a simple blood test can predict patients at risk for significant episodes of confusion and disorientation that can occur in patients who receive an artificial shunt through the liver to control complications of liver disease.


Eligibility criteria:
inclusion criteria: * subjects over the age of 18 able to provide consent * subjects undergoing initial tips procedure for the primary indication of treatment of ascites exclusion criteria: * prisoners * pregnant women * subjects undergoing tips placement as part of an investigational study outside of usual clinical care * subjects taking beta-blocker medications or angiotensin converting enzyme inhibitors * subjects with evidence of porto-systemic shunts present on imaging (eg splenorenal shunt) * subjects with calculated meld score \>12 based on most recent laboratory values before consent * subjects with prior history of overt hepatic encephalopathy (grade 3-4) that was primary reason for hospitalization. episodes of hepatic encephalopathy that were the consequence of other precipitating event (such as variceal bleeding or infection) will not be considered exclusionary. * subjects with a known sensitivity to albumin preparations, any ingredient in the formulation, or components of the container * subjects unable to fast for \>5 hours prior to the hepquant administration or subjects who are unable to drink the oral dose of the cholate (\~40ml of liquid).
fibromyalgia integrative training for adolescents with juvenile fibromyalgia

Conditions: Fibromyalgia; Myofascial Pain Syndrome; Muscular Diseases; Musculoskeletal Disease; Rheumatic Diseases

Summary: this study evaluated whether fibromyalgia integrative training program for teens (fit teens), a combined cognitive behavioral therapy and neuromuscular exercise training program is more effective in reducing disability in adolescents with juvenile fibromyalgia compared to cognitive behavioral therapy (cbt) alone or a graded aerobic exercise (gae) program alone. one third of participants received the fit teens training; one third received cbt training; and one third of participants received the gae training.

juvenile-onset fibromyalgia (jfm) is a chronic, debilitating pain condition that typically persists into adulthood for the majority of patients. whereas medications offer limited and short-term symptom relief for jfm, our research group has demonstrated that cognitive-behavioral therapy (cbt) is safe, effective and durable in reducing functional disability and depressive symptoms in adolescents with this condition. however, 60% of patients receiving cbt did not show clinically significant improvement in functional disability, and pain levels remained in the moderate range despite being reduced overall. our multidisciplinary team of experts in behavioral medicine, rheumatology and exercise science has developed and tested the feasibility of a new fibromyalgia integrative training program for teens (fit teens), which enhances the established cbt intervention with a novel neuromuscular exercise training program derived from evidence-based pediatric injury prevention research. pilot testing showed excellent patient engagement, no adverse effects and very promising early results indicating this treatment to have even stronger effects on disability and pain outcomes than cbt alone. this trial evaluated whether the fit teens intervention is more effective than cbt alone or graded aerobic exercise alone and whether treatment effects are sustainable over 1 year follow-up.

Eligibility criteria:
inclusion criteria: * juvenile fibromyalgia diagnosis by pediatric rheumatologist or pain physician and confirmed by 2010 american college of rheumatology (acr) criteria modified for pediatric use * functional disability score ≥ 13, indicating at least moderate disability * average pain intensity in the past week ≥ 4 on a 0 -10 cm visual analog scale * stable medications prior to enrollment exclusion criteria: * comorbid rheumatic disease (e.g. juvenile arthritis, systemic lupus erythematous) * untreated major psychiatric diagnoses (e.g. bipolar disorder, psychoses, symptoms of major depression) or documented developmental delay * any medical condition determined by their physician to be a contraindication for physical exercise * taking opioid pain medication

Keywords: juvenile fibromyalgia pain in children musculoskeletal pain cognitive behavioral therapy coping skills training neuromuscular exercise graded aerobic exercise
interest of simulation as part of the procedure tracheobronchial aspiration

Conditions: Tracheobronchial Anomalies

Summary: the aim of this study is to compare a control group (practical work group) with a high fidelity stimulation group about competences and reasoning clinic.

health simulation is in full development on the national territory (france). the medical profession and nurses use this mode of learning in initial training to improve the students skills the report of pr granry allowed an inventory of the simulation in france with as leitmotiv "never the first time for the patient". it has also put in place priorities for the coming years, one of which is to develop simulation in initial and in-service training. this learning technique is interesting according to several parameters. first,is the safety of care. a novice who has already practiced on a mannequin or in the context of the simulation will be able to better understand the situation of care in the clinical field. the quality of care is also improved by the practice of simulation including communication skills, psychomotor skills, respect for procedures and theoretical knowledge. this more or less faithful reproduction is all the more necessary as the duration of clinical placements is decreasing. simulation is a way to mitigate this lack is allows a faithful immersion in the care environment. despite all these positive points, physiotherapy is not yet very affected by the simulation as shown in the literature gordon's review (2015). initial training, continuing education has not to this day largely developed this teaching method . some timid uses have taken place and for the most part in anglo-saxon countries with various modes of simulation. in france, certainly linked to the specificity of the profession, its implementation is delicate, even complicated. it remains anecdotal to this day.

Eligibility criteria:
inclusion criteria: * learners: all second year students enrolled in initial training of the institute of kinesitherapy of toulouse during the year 2017-2018. in total 45 students. * patients :all adult patients with tracheotomy, and able to communicate. patients hospitalized in the university hospital de toulouse exclusion criteria: * learners: students absent on the day of the reading of the procedures * patients:adolescent patients, child patients, patients with a communication deficit, patients under respirators

Keywords: high fidelity simulation training physiotherapy tracheobronchial aspiration.
role of prf with mta and theracal after pulpotomy in relieving pain

Conditions: Neuritis

Summary: this research will evaluate the effect of prf with different bioactive materials in dentistry

prf will be used with mta and theracal to evaluate its effect upon these materials in reliving pain and maintains the teeth vitality in permanent teeth with closed apices, in order to improve the materials outcome.

Eligibility criteria:
inclusion criteria: * patients suffering from symptomatic pulpitis. * patients should be free from any systemic disease that may affect normal healing and predictable outcome. * patients who will agree to the consent and will commit to follow-up period. * patients with mature root. * patients with no periapical lesion. * patients with localized pain. * posterior teeth only will be involved exclusion criteria: * patients with immature roots. * patients with any systemic disease that may affect normal healing. * patients with periapical lesions or infections. * pregnant females. * patients who could/would not participate in a 1-year follow-up. * patients with fistula. * patients with necrotic pulp. * patients with old age.