Kornimate/medical-research-clean huggingface dataset:
pressure ulcers in patients receiving enteral nutrition therapy and their relationship with gut microbiota

Conditions: Malnutrition; Pressure Ulcer

Summary: participants will be randomly assigned to the experimental group where they will be given enteral nutrition formula rich in zinc and arginine plus a symbiotic (probinul- ca.di.group s.r.l.) once a day for 90 days or the control group where they will receive only the enteral nutrition formula rich in zinc and arginine.

participants belonging to both experimental and control group will be evaluated at admission (t0), 45 days after admission (t45) and at the end of the study (t90, 90 days after admission). at each time point patients' nutritional status will be determined and the following biochemical parameters will be investigated: lymphocyte count, total proteins, protidogram, prealbumin, transferrin, vascular endothelial growth factor (vegf), platelet-derived growth factor (pdgf), beta transforming growth factor (tgf-beta). analysis of fecal dna will be also performed to characterize the gut microbiota. in addition, at the baseline and at t45 participants will be administered the braden scale for predicting pressure sore risk.

Eligibility criteria:
inclusion criteria: * patients with enteral nutrition therapy * presence of pressure ulcers * previous antibiotic therapy exclusion criteria: * nutrition per os * absence of pressure ulcers * absence of previous antibiotic therapy

Keywords: gut microbiota iatrogenic malnutrition pressure ulcer
the effectiveness of lay health advisors strategy intervention on aborigines elderly oral care education

Conditions: Oral Health

Summary: in the present study, the investigators aimed to evaluate the effectiveness of community-based oral exercise with lha intervention on the oral health-related quality of life, oral function and oral self-care behaviors. this randomized controlled trial included lha group (eg) and leaflet group (cg), respectively. the eg received a four-week one-on-one session by an lha. baseline and follow-up data collection were used to collect the data in oral self-care behaviors, oral hygiene, oral function and quality of life.

a randomized controlled trial (rct) was conducted. the participants recruited from aboriginal communities in eastern taiwan. data collecting time was from 2019 to 2020. participants from the identified communities were randomly assigned to eg or cg using random table. participants who were 55 years old or above and indigenous people were recruited in the study. participants who were disability, have had oral cancer, impaired facial appearance and impaired cognitive function were excluded. impaired cognitive function was screening by short portable mental status questionnaire (spmsq). participants were recruited according to the predetermined minimal sample size estimated based on a type i error = 0.05, power = 0.95, and effect size (es) f = 0.25 (medium effect in cohen's f) . the number of samples in each group was expected 66 participants. an additional 30% drop out rate was added. the final number of samples for each group were required at least 86 participants. the total sample size was 122 and 118 in eg and cg, respectively. all participants underwent data collection at baseline and at 2-week, 3-and 6-month follow-ups.

Eligibility criteria:
inclusion criteria: * 55 years old or above and indigenous people exclusion criteria: * disability, have had oral cancer, impaired facial appearance and impaired cognitive function were excluded. impaired cognitive function was screening by short portable mental status questionnaire (spmsq).

Keywords: aboriginal lay health advisor oral hygiene quality of life oral function
an extension trial to a phase i dose escalation study of gimatecan administered orally 5 consecutive days to japanese patients with advanced solid tumor

Conditions: Advanced Solid Tumors

Summary: clbq707a1101 assesses the tolerability, safety, efficacy and pharmacokinetics of gimatecan in japanese patients.


Eligibility criteria:
inclusion criteria: * patients completing the core protocol (clbq707a1101, nct00410358) exhibiting stable disease, or a partial or complete response as defined by the core protocol. if patients only have non-measurable lesions, he/she must not be exhibiting progressive disease exclusion criteria: * documented progressive disease as defined by the core protocol * patients with performance status of 3 or 4 on the ecog scale other protocol-defined inclusion/exclusion criteria may apply

Keywords: gimatecan topoisomerase i inhibitor advanced solid tumors
use of whole-body periodic acceleration therapy to aches and pains

Conditions: Pain; Stiffness; Abnormal Gait; Balance

Summary: the purpose of this study is to test the effectiveness of whole body periodic acceleration for helping with symptoms of aches and pains suffered by many patients.

this is an unblinded cross-over study of whole-body periodic acceleration (wbpa) to ascertain if this treatment modality provides symptomatic relief of pain, stiffness, and abnormal gait and balance in a variety of conditions. the study will compare a specific mechanism of motion, whole-body periodic acceleration (wbpa), that has been shown to increase the release of beneficial mediators from the vascular endothelium into the circulation, to a control condition of slow passive motion that promotes relaxation but does not increase release of beneficial mediators into the circulation. the study tests the efficacy and safety of a commercially available device that consists of a motion platform, called exer-rest©, that is capable of producing both types of motion to be tested. in this investigation, 15 subjects will be randomly assigned to either procedure for 10 treatments for 2 weeks followed by a one-week "wash-out" period. then the opposite treatment will be employed for two weeks.

Eligibility criteria:
inclusion criteria: subjects qualifying for this study satisfy the following criteria: 1. over 18 years of age; 2. complain of either chronic pain, joint stiffness, and/or dysfunctions of gait and balance; 3. complaints have been annotated by a competent physician, and the subject has been evaluated for conditions that commonly contribute to the respective symptoms; 4. capable of completing the appropriate testing and baseline assessments, such as quantitative electroencephalography (qeeg) and questionnaires; 5. tolerate the motion and duration of treatment of the wbpa. 6. be available for regular visits to the research site for the duration of the study. exclusion criteria: wbpa is contraindicated for subjects who are pregnant or who suffer with unexplained leg pain, skin eruptions, or who have unstable spinal injuries or conditions. subjects who cannot tolerate the motion and duration of treatment are also excluded.

Keywords: motion platform at appropriate settings. relief of pain. improvement in quality of life, cognition, and mood. effects of wbpa on cognition, mood, behavior, and functioning. dose response effect . gather data for long-term (2 year) study
probiotics for the prevention of major complications of cirrhosis

Conditions: Liver Cirrhosis

Summary: the purpose of this study is to determine whether probiotics are effective in the prevention of the complications of liver cirrhosis.

colonic bacteria clearly play a major role in the pathogenesis of major complications in patients with liver cirrhosis. by producing ammonia and endotoxins they can cause hepatic encephalopathy , and their translocation from the gut to the peritoneal cavity is the major mechanism for spontaneous bacterial peritonitis. there are also new studies suggesting a possible connection between bacterial translocation and bleeding from esophageal varices. some of the therapeutic measures for the treatment and prevention of complications in cirrhotic patients, such as antibiotics and lactulose, are partially directed against gut bacteria. in recent years there is a growing interest in the effect of probiotic bacteria on gut flora and prevention of infection. they were found to prevent pediatric infectious diarrhea and antibiotic-associated diarrhea- especially those caused by clostridium difficile. the probiotic bacteria, among which the most common are the lactose fermenting lactobacilli, inhibit the growth of pathogenic bacteria by acidifying the gut lumen, competing for nutrients, and by producing antimicrobial substances. they adhere to the gut mucosa and by that are thought to prevent bacterial translocation from the gut. these effects of probiotics raised the idea that they may have a role in the treatment and prevention of cirrhosis complications. a recent study examined the effect of probiotics on patients with minimal chronic hepatic encephalopathy. hepatic encephalopathy was reversed in 50% of the patients receiving probiotics. these patients also demonstrated a significant reduction of blood levels of ammonia, bilirubin and alt, and of pathologic bacteria in stool cultures. this study showed promising results but was carried out on a relatively small population. furthermore, the effect of probiotics on the prevention of hepatic encephalopathy and other major complications of cirrhosis has not been studied yet. therefore, more studies are needed to establish the role of probiotics in patients with cirrhosis.

Eligibility criteria:
inclusion criteria: patients with liver cirrhosis with at least one of the followings 1)major complication of cirrhosis in the past (including variceal bleeding, encephalopathy and sbp) 2)evidence for portal hypertension 3)reduced hepatic synthetic function - exclusion criteria: 1. patients with alcoholic cirrhosis who still consume alcohol 2. patients that are chronically treated with antibiotics or lactulose -

Keywords: cirrhosis probiotics hepatic encephalopathy ammonia
language treatment for progressive aphasia

Conditions: Primary Progressive Aphasia; Nonfluent Progressive Aphasia; Semantic Dementia

Summary: progressive aphasia is characterized by a steady and progressive loss of language skills in the presence of relatively preserved memory, attention, and thinking. the aim of this study is to slow the progression of language decline in progressive aphasia via language therapy. the first goal of this study is to improve naming abilities of individuals with progressive aphasia. this will be accomplished by carrying out an intensive treatment program for anomia. the second goal is to evaluate whether this intense language treatment re-activates affected areas and/or connections within the language network, using functional magnetic resonance imaging (to measure neural activity in specific brain regions) and diffusion tensor imaging tractography (to measure the connectivity between specific brain regions). this is the first study on progressive aphasia addressing both treatment and imaging in the same patients.


Eligibility criteria:
inclusion criteria: * diagnosis of progressive aphasia * native english speaker or fluent in english * adequate hearing and vision (not requiring more than +6 diopter correction) * willing and able to participate in each phase of the study (including two fmri sessions) exclusion criteria: * contraindications to fmri (e.g., claustrophobia, pacemaker, ferromagnetic implant) * current medical or psychiatric condition affecting cognition (other than progressive aphasia)

Keywords: progressive aphasia semantic dementia neuroimaging treatment errorless learning
geriatrics in the intensive care unit

Conditions: Geriatrics

Summary: life expectancy is longer in populations of medium- and high-income countries. older adults are an increasingly large population in intensive care units (icus). there are limited publications about the epidemiology, benefits, expenditure, and outcomes of elderly and very old critically ill patients. we are designing a study to characterize older adults admitted to the intensive care unit and determine factors associated with adverse outcomes. the discharge registry of the icu of a third-level hospital was reviewed. records from january to december 2024 were reviewed. three age groups were selected for comparison: a. \<65 years; b. 65-79 years; c. 80 years and above. the outcomes to compare will be: mortality, need for invasive mechanical ventilation, icu length of stay, and duration of mechanical ventilation.

background: older adults represent a significant and increasing proportion of patients admitted to the intensive care unit, as the population's life expectancy is longer. the study aims to investigate factors associated with mortality in geriatric patients receiving critical care. methodology: we are designing a retrospective analytical cross-sectional clinical trial. the discharge records from january to december 2024 of one of the intensive care units (icus) from the orinoco region in colombia will be reviewed. the records will be divided into three groups for comparison: a. lower than 65 years; b. between 65 and 79 years; c. 80 years and older. the records of patients admitted to the intermediate unit will be excluded. outcomes to be evaluated will include mortality, icu length of stay, invasive mechanical ventilation (imv), and duration of imv. the data will be exported to excel. the frequency and proportion of categorical variables will be described. the central distribution and dispersion of quantitative variables will also be defined. chi-square and mann-whitney u tests will be used for the statistical comparison of the variables. a value \<0.05 of p will be designated as statistical significance. results: the frequency of older adults admitted to the icu will be revealed at the end of the study. the outcomes and factors associated with mortality by age groups will be discriminated. conclusions: the study is feasible, pertinent, affordable, and essential for the region, as it will optimize resource planning and improve healthcare for critically ill older adults.

Eligibility criteria:
inclusion criteria: * registry of adults older than 18 years, discharged from the critical care unit. exclusion criteria: * none.

Keywords: aged frail older adults intensive care units critical illness colombia
screening and molecular diagnosis-based individualized precision management of monogenic diabetes

Conditions: Monogenic Diabetes

Summary: the goal of this observational study is to establish a registry, screening, and individualized management platform for patients with monogenic diabetes mellitus(mdm) using internet-based and mobile application software. the main questions it aims to answer are: * what are the genetic mutations causing mdm in china (genetic landscape)? * how effective and safe is the individualized, molecular-diagnosis-based management platform for mdm in improving patient outcomes? participants will: * register in the mdm platform via mobile app or internet-based software * undergo genetic screening for mdm diagnosis * participate in follow-up visits for individualized management and monitoring of blood glucose control and outcomes


Eligibility criteria:
inclusion criteria: 1. diabetes patients who developed before 25 years old; or they were diagnosed with diabetes before the age of 35, and two or more immediate relatives were diagnosed with diabetes before the age of 45; 2. body mass index (bmi) at diagnosis \< 28 kg/m2; 3. anti glutamic acid decarboxylase antibody (gad ab), anti islet cell antibody (ica ab), and anti insulin autoantibody (iaa ab) were all negative; exclusion criteria: 1. secondary diabetes patients with other endocrine diseases, such as hyperthyroidism or hypothyroidism, hyperparathyroidism or hypothyroidism, acromegaly, cushing's syndrome, autoimmune multiple endocrine diseases, etc.; 2. systemic use of corticosteroids, immunosuppressants, and other drugs within the past 6 months; 3. patients with malignant tumors.
effect of different administration routes of dexmedetomidine combined with ultrasound-guided fascia iliaca block on emergence agitation after hip replacement surgery

Conditions: Dexmedetomidine; Fascia Iliaca Block

Summary: to examine the impact of various administration routes of dexmedetomidine in conjunction with ultrasound-guided fascia iliaca block (fib) on emergence agitation (ea) during the postoperative recovery period after hip replacement surgery.


Eligibility criteria:
inclusion criteria: 1. age between 18 and 65 years, with no restriction on gender 2. diagnosis of hip joint disease necessitating hip arthroplasty 3. asa grade i-ii 4. no significant cardiopulmonary, hepatic, or renal dysfunction prior to the operation 5. no history of psychiatric disorders or long-term use of sedative medications prior to the operation 6. signing of an informed consent form to voluntarily participate in the study. exclusion criteria: 1. patients allergic to or with contraindications to ropivacaine or dexmedetomidine 2. patients exhibiting symptoms of agitation or delirium prior to the procedure 3. patients with severe central or peripheral nervous system disorders 4. patients with coagulation disorders or receiving anticoagulant therapy 5. pregnant or breastfeeding women 6. patients who received other medications or treatments prior to the procedure that might affect the study results 7. patients unable to cooperate with the study or intolerant to ultrasound-guided iliofascial block

Keywords: fascia iliaca block dexmedetomidine emergence agitation ropivacaine analgesic mechanism
an analysis of blood management in patients having hip or knee arthroplasty

Conditions: Transfusion-dependent Anemia

Summary: the main objective of this study is to examine the transfusion rate and appropriateness in patients undergoing elective knee and hip replacement surgery at siriraj hospital

the main objective of this study is to examine the transfusion rate and appropriateness in patients undergoing elective knee and hip replacement surgery at siriraj hospita by reviewing data from previous medical records (retrospective chart review).

Eligibility criteria:
inclusion criteria: * patients having elective hip or knee arthroplasty in siriraj hospital exclusion criteria: * none
behavioural treatment of hypertension

Conditions: Hypertension

Summary: the objective of the study is to determine whether psychological therapy (self-help or individualized intense stress management) is different than a single drug treatment in terms of their effectiveness for lowering blood pressure.


Eligibility criteria:
inclusion criteria: * must be at least 19 years of age * subjects can be male or female * subjects must have an average resting blood pressure of \>140 systolic pressure an/ or \>90 diastolic pressure off anti-hypertensive medication exclusion criteria: * must not be on more than 2 blood pressure lowering drugs * must not have known or suspected of having secondary hypertension on initial examination * must not be pregnant or anticipating pregnancy during study period * must not have history of allergy, hypersensitivity or intolerance to diuretics * must not have medical condition that may result in an unacceptable risk of complications due to uncontrolled hypertension during time period of study * must not have average resting bp readings that exceed 190 systolic, or 115 diastolic, or have two consecutive readings of 180 systolic or 110 diastolic

Keywords: hypertension, ambulatory bp, office resting bp, hydrochlorothiazide, stress reduction, self-help, psychotherapy, efficacy
comparing detection of standard colonoscopy, cad-eye and combined cad-eye and g-eye® aided colonoscopy

Conditions: Colorectal Cancer; Adenoma

Summary: the purpose of this study is to compare the additional diagnostic yield over standard colonoscopy (i.e., the adenoma miss-rate reduction) obtained by performing cadeye and g-eye® aided colonoscopy, vs. the additional diagnostic yield over standard colonoscopy (i.e., the adenoma miss-rate reduction) obtained by performing cad-eye aided colonoscopy.

the purpose of this study is to compare the additional diagnostic yield over standard colonoscopy (i.e., the adenoma miss-rate reduction) obtained by performing cadeye and g-eye® aided colonoscopy, vs. the additional diagnostic yield over standard colonoscopy (i.e., the adenoma miss-rate reduction) obtained by performing cad-eye aided colonoscopy. this is a single-center, four-arm dual-tandem, randomized, open-label study intended to compare the additional detection yield beyond standard colonoscopy obtained by performing combined cad-eye and g-eye® high definition colonoscopy vs. the additional detection yield beyond standard colonoscopy obtained by performing cad-eye high definition colonoscopy. consecutive adult subjects who were referred for elective colonoscopy will be asked to enroll into this randomized clinical study if the candidate meets the study inclusion and exclusion criteria

Eligibility criteria:
inclusion criteria: 1. screening and surveillance population for adenoma and crc. 2. subjects age is at least 18 years 3. the patient must understand and sign a written informed consent for the procedure. exclusion criteria: 1. subjects with inflammatory bowel disease; 2. subjects with a personal history of hereditary polyposis syndrome; 3. subjects with suspected chronic stricture potentially precluding complete colonoscopy; 4. subjects with diverticulitis or toxic megacolon; 5. subjects with prior colonic surgery (exclusion appendectomy) 6. subjects with a history of radiation therapy to abdomen or pelvis; 7. pregnant or lactating female subjects; 8. subjects who are currently enrolled in another clinical investigation. 9. subjects with current oral or parenteral use of anticoagulants, not considered eligible by the investigator. 10. subjects with recent (within the last 3 mounts) coronary ischemia or cva (stroke) 11. any patient condition deemed too risky for the study by the investigator

Keywords: g-eye colonoscopy cad-eye adenoma colorectal cancer
the impact of psychological factors on the outcome of surgical repair for rotator cuff

Conditions: Rotator Cuff Tear

Summary: the proposed study will be a multi-centre, prospective, observational cohort to determine if psychological well-being has an impact on the outcome of surgical repair for rotator cuff tears.

this study will take place at multiple centres across the university of toronto network. the primary outcome of interest will be the western ontario rotator cuff index (worc) measured at one year following surgery. the worc is a disease specific, quality of life measurement tool with 21 questions separated into 5 domains: physical symptoms, sports/recreation, work, lifestyle, and emotion. secondary outcomes of interest will be the constant murley score (cms), which relies on subjective as well as objective components of scoring, and the eq-5d-5l which will be used as a general measure of health. psychological well-being will be measured using the patient health questionnaire-8 (phq-8), the 7-item general anxiety disorder scale (gad-7), the patient catastrophizing scale (pcs) , and the expectations survey from the musculoskeletal outcomes data evaluation and management system \[modems\] . post-operative satisfaction will be measured using the modems satisfaction survey.

Eligibility criteria:
inclusion criteria: * males and females aged 35-80 * symptomatic, full-thickness tear of the rotator cuff, confirmed by mri examination * patients undergoing rotator cuff repair * symptoms must have been present for 3 or more months exclusion criteria: * patients undergoing subacromial decompression alone * glenohumeral arthritis of grade 2 or higher * patients undergoing revision surgery * patients receiving workplace safety and insurance board (wsib) benefits * neurologic disorder affecting the upper extremity * injury to the rotator cuff sustained as a result of polytrauma, or any other significant injuries sustained that the treating surgeon believes will have an effect on the recovery from rotator cuff repair surgery * patients involved in a legal case/proceedings or seeking legal advice related to the injury sustained to the rotator cuff