Kornimate/medical-research-clean huggingface dataset:
efficacy of a positive psychological intervention in patients with eating disorders

Conditions: Eating Disorder; Daily Activities

Summary: this study is aimed to test the efficacy of a positive psychological intervention for promoting positive emotions and optimistic thinking in eating disordered patients. participants are randomly assigned to receive the positive intervention or the control condition, which consists on thinking about daily activities.

eating disorders (ed) are very difficult conditions to treat. therefore, interventions in this field are shifting their main target towards the disorder's impact in quality of life, rather than ed symptomatology in itself. in this sense, a focus in the promotion of positive emotions and well-being is emerging in order to buffer from the harmful effects caused by ed. positive psychological interventions have shown efficacy in the promotion of positive emotions and well-being. in this sense, one of these interventions is called best possible self (bps), since is aimed to enhance positive emotions and well-being. specifically, bps is a positive future thinking technique, which requires people to envision themselves in the future, after everything has gone as good as it possibly could. this exercise has shown efficacy improving optimism, future expectancies and positive affect compared to a control condition, in general population and depressive patients. furthermore, the progress of information and communication technologies, has allowed the development of technology applications and devices that could enhance the quality of experience and the well-being levels. this approach is called positive technology and it can be used as a complement to positive psychological interventions. positive technology can be defined as the scientific and applied approach to improve the quality of our personal experience trying to increase wellness and generate strengths. taking into account the prior literature, the aim of the present study is to carry out a randomized controlled study with ed patients in order to explore if bps is able to produce improvements in different well-being and clinical measures. the exercise will be applied through a positive technology system. the design employed in this study is similar to the used in other studies. five assessment moments were used: before the exercise (baseline), after the first session (day 1) and post-training (1 month). moreover, two follow-ups were included: one month after finishing the training period (1st follow-up) and three months after finishing the training (2nd follow-up)

Eligibility criteria:
inclusion criteria: * subject has a diagnosis of eating disorder by a clinical psychologist according to dsm-iv criteria * subject accepts to participate in the study voluntarily exclusion criteria: * subject suffering a severe physical condition * subject suffering from substance or alcohol depedence

Keywords: best possible self
estimating average vitamin a requirements in indonesian and american women

Conditions: Vitamin A Deficiency

Summary: women of reproductive age had their vitamin a stores estimated by retinol isotope dilution and then were given vitamin a supplements near the us vitamin a rda or placebo for 42(usa) or 60 (indonesia) days, after which retinol isotope dilution was repeated and the change in vitamin a stores was determined in each group to estimate how much vitamin a is needed to maintain nutrient balance in these women.


Eligibility criteria:
inclusion criteria: * normal nutritional status (bmi 18.5-25) exclusion criteria: * significant clinical illness
comparative study of efficacy of 10 mg dequalinium chloride (fluomizin) in the local treatment of bacterial vaginosis

Conditions: Bacterial Vaginosis

Summary: the purpose of this clinical study was to evaluate whether vaginal tablets containing 10 mg dequalinium chloride (fluomizin) are comparable in clinical efficacy and safety to clindamycin vaginal cream (2%) in patients suffering from bacterial vaginosis.

an international, multi-center, single-blind, randomized, active-controlled study with two parallel groups in patients with bacterial vaginosis. eligible patients were randomized to receive fluomizin vaginal tablets for 6 days or clindamycin vaginal cream (2%) for 7 days. control examinations were performed 3 to 14 days and 2 to 6 weeks after the end of the therapy.

Eligibility criteria:
inclusion criteria: * diagnosis of bacterial vaginosis * women aged 18-55 years exclusion criteria: * pregnancy or lactation * uterine bleeding (including menstruation but not including cervical contact bleeding on sampling) or vaginal bleeding of unknown origin * acute infections of the upper genital tract * clinical symptoms of a vulvovaginal candidiasis * use of anti-infectives (local or systemic) in the previous 14 days and/or during the study

Keywords: fluomizin dequalinium chloride bacterial vaginosis vaginal therapy
regional anesthesia / peripheral nerve block and general anesthesia on preoperative anxiety

Conditions: Anxiety Disorders

Summary: the researchers aimed to investigate that preoperative anxiety scores of patients who are informed about the anesthesia before surgery with using state-trait anxiety inventory and amsterdam preoperative anxiety and information scale tests together.

patients will be informed about the anesthesia procedure in service ad then it will be held anxiety questionnaires one day before surgery and operation rooms.

Eligibility criteria:
inclusion criteria: * aged between 18 and 80, * both women and men, * patients will be operated exclusion criteria: * psychiatric and neurologic diseases, * hearing and speech disorders, * psychiatric drug and chronic alcohol use
a problem solving intervention for hospice caregivers

Conditions: Anxiety Generalized; Quality of Life; Depression

Summary: hospice care is conceptualized as quality compassionate care for people facing a life-limiting illness, with services that cover clinical care, pain management, and emotional and spiritual support tailored to patients' and families' needs and preferences. family members, spouses, friends or others who assume the unpaid or informal caregiving role are essential to the delivery of hospice services; however, stress and caregiver burden can negatively affect caregivers' morbidity and mortality. the emotional needs of individuals caring for dying persons at home are not well attended, and interventions aiming to provide support to hospice caregivers are notably lacking. the investigator team recently completed a study with 514 hospice caregivers to test a problem-solving therapy (pst) intervention tailored specifically for the hospice setting, entitled pisces (problem-solving intervention to support caregivers in end of life care settings). the findings demonstrate that the pisces intervention when delivered face to face was effective leading to statistically significant decrease in anxiety and increase in quality of life when compared to the other groups (video group and attention control). an additional lesson learned from that rct study was that caregivers wanted to focus not only on specific problems or challenges, but also on recognizing the positive aspects of caregiving. this approach of positive reappraisal has been found to enhance problem solving interventions in other settings. the specific aims of this new study are: 1) to compare the effectiveness of the pisces intervention when delivered face to face and when delivered in a hybrid platform (with the first session in person and remaining sessions via video) to hospice caregivers; 2) to compare the effectiveness of the pisces intervention to the refined pisces intervention (piscesplus) that integrates positive reappraisal elements; 3) to assess caregivers' perceptions of and satisfaction with the piscesplus intervention; and 4) to conduct a cost analysis of the three intervention groups.


Eligibility criteria:
inclusion criteria: * enrolled as a family/informal caregiver of a hospice patient * 18 years or older * with access to a standard phone line or internet and computer access at home * without functional hearing loss or with a hearing aid that allows the participant to conduct telephone conversations as assessed by the research staff (by questioning and observing the caregiver) * speak and read english, with at least a 6th-grade education exclusion criteria: * hearing or visual impairment that prohibits from conducting phone conversations or video conference sessions
a study of b013 in combination with paclitaxel in patients with platinum-resistant recurrent ovarian cancer.

Conditions: Platinum-resistant Recurrent Ovarian Cancer

Summary: to evaluate the efficacy and safety of b013 in patients with platinum-resistant recurrent ovarian cancer.


Eligibility criteria:
inclusion criteria: 1. subjects who voluntarily participate in this study and sign informed consent form; 2. ovarian cancer, fallopian tube cancer or primary peritoneal cancer confirmed by histopathological examination and meeting the criteria for platinum resistance recurrence; 3. ecog performance status of 0 or 1； 4. expected survival \> 12 weeks; 5. the subject has at least one measurable lesion; 6. normal function of major organs; 7. the fertile subjects agree to use reliable contraception from signing the informed consent to at least 6 months after the last dose. exclusion criteria: 1. subjects who have received prescribed treatment previously; 2. subjects who are still using anti-tumor traditional chinese patent medicines at the time of signing informed consent; 3. subjects with known central nervous system metastasis and multiple bone metastasis; 4. subjects who had clinical symptoms of pleural effusion, pericardial effusion or ascites before randomization and needed puncture drainage, or had received puncture drainage within the previous 2 weeks; 5. have a history of other malignant tumors within 5 years before signing the informed consent; 6. subjects with prescribed cardiovascular diseases; 7. subjects with infections requiring intravenous antibiotic infusion within 2 weeks prior to randomization; 8. had severe lung disease before randomization; 9. before randomization, the peripheral nerve toxicity of previous anti-tumor treatment was \> grade 2, and other reversible toxicity was \> grade 1; 10. subjects who had undergone surgery within 28 days prior to randomization and did not recover from adverse effects of surgery; 11. subjects who participated in clinical trials within 30 days prior to randomization and received other unmarketed investigational drugs; 12. subjects who are known to be allergic to any component of b013 or paclitaxel. 13. subjects with a known history of substance abuse, alcohol or drug use; subjects with a known history of neurological or psychiatric disorders; 14. female subjects who are pregnant or breastfeeding; 15. other situations determined by the researchers and/or sponsors as unsuitable for participation in this trial.
investıgatıon of temporomandıbular dysfunctıon in patıents wıth breast cancer-related lymphedema

Conditions: Breast Cancer; Lymphedema

Summary: this study is the first study to examine temporomandibular joint dysfunction (tmd) in patients with breast cancer. the aim of the study was to investigate the relationship between lymphedema (lö) and tmd in patients with breast cancer. socio-demographic characteristics of 38 individuals included in the study were recorded. patients were divided into stage 0, 1 and 2 groups according to their lö stage and mild, moderate and advanced groups according to their tmd levels. in the evaluation of severity of lymphedema, symptoms and signs of tmd, pain threshold and tolerance assessment and normal range of motion, anxiety and depression, posture analysis environmental measurement, craniomandibular dysfunction index for clinical, visual analogue scale (vas) and algometer , goniometer and inclinometer, turkish version of the hospital anxiety and depression scale (had) ,photogrammetric assessment method and inclinometer were used


Eligibility criteria:
inclusion criteria: * female patients aged 18-75 years who were treated for unilateral breast cancer and developed breast cancer-related le were included in the study exclusion criteria: * patients with general joint diseases affecting the head and neck region that may cause tmd (e.g. rheumatoid arthritis), * jaw fracture, * trauma or orthognathic surgery history, * cervical disc herniation, * congenital disease, * facial paralysis, * patients who have been treated for tmd for the last 3 months and patients who use antidepressant drugs were excluded.
clinical evaluation of antiseptic skin preparation in revision total joint arthroplasty of the hip and knee

Conditions: Revision Total Hip Arthroplasty (RTHA); Revision Total Knee Arthroplasty

Summary: the goal of this clinical trial is to compare two types of skin preparation solutions (chlorhexidine gluconate-alcohol solution and povidone-iodine solution) that help eliminate harmful bacteria on the skin at the time of surgery for patients having revision arthroplasty surgery of the hip or knee. the main outcome of interest for the definitive study is the need for re-operation for a wound complication or an infection of the prosthetic joint within one year after surgery. for the pilot trial, our main interest is to determine feasibility of a definitive trial. feasibility outcomes will include: ability to recruit patients, ability to randomize patients, ability to collect complete data, estimate the event rate of our primary outcome, ability to carry out data linkages and determine the accuracy of collected data. participants will be contacted at two time points after surgery to complete a 5-minute survey: after 30 days, and after 1 year.

in this trial, participants will be assigned randomly to have their surgical skin site prepared for surgery with either chlorhexidine gluconate-alcohol solution or povidone-iodine solution. these are two types of solutions that have antiseptic properties, which means they help eliminate harmful bacteria on the skin at the time of surgery, and therefore, reduce the risk of infection. surgeons routinely use either chlorhexidine-based or iodine-based skin preparation solutions at the time of surgery to sterilize the surgical area. however, we don't know which one works best for patients having revision joint replacement surgery. there is a small chance of having an allergic reaction to the chlorhexidine or iodine, but there is no additional risk by participating in this study, as these skin preparation solutions are routinely used in practice. the main outcome of interest is the need for re-operation for a wound complication or an infection of the prosthetic joint within one year after surgery. other key outcomes are surgical site infection, mortality, and readmission to hospital. participants will be contacted 30 days after surgery to complete a survey online, by phone, or in person, which will take approximately 5 minutes to complete. all other outcome data will be collected by phone call, health records, routine hospital monitoring, or electronic registry data at thirty days and one year after surgery.

Eligibility criteria:
inclusion criteria: 1. aged 18 years or older 2. scheduled to undergo aseptic revision total hip arthroplasty or total knee arthroplasty with exchange of at least one prosthetic component exclusion criteria: 1. revision for prosthetic joint infection or wound complication 2. known history of previous prosthetic joint infection in the operative joint 3. any degree of clinical concern for prosthetic joint infection 4. history of allergy to iodine, chlorhexidine, or alcohol

Keywords: prosthetic joint infection registry-based rct pji
mindfulness-based childbirth and parenting education on pregnant women

Conditions: Stress, Psychological; Pregnancy Related

Summary: the purpose of this study is to explore the differences between stress, depression, childbirth self-efficacy, mindfulness and postnatal maternal outcomes in pregnant women with mindfulness-based childbirth and parenting education program.

being a mother is a huge change for women, and she will undergo a high degree of change and a strong threat in this transformation process. the purpose of this study is to explore the efficacy of a mindfulness-based childbirth and parenting(mbcp) education program on prenatal stress, depression, mindfulness, childbirth self-efficacy, and postnatal maternal outcomes. randomized controlled trial comparing two education programs with health and singleton pregnant women is run by the random allocation software (saghaei, 2004). use the g-power 3.1.9 windows: repeated measures and between factors among two groups to calculate the number of samples, and setting the power = .8, α = .05, effect size = .25. the estimated number of samples may be lost 20%, total 104 samples ( 52 samples in each group). the protocol for the study used mbcp education, this program helps participants practice in the present moment, so that they may develop more confidence and well-being during pregnancy. the mbcp course is held for 3 hrs once a week for 8 weeks. they also had the home practice of 30 minutes a day with a dvd for the experimental group. the control group attending a hospital-based antenatal education program for 2 hrs once a month for 2 months from hospital staff nurses in all aspects of pregnancy, childbirth and postpartum. this study uses a standard verbal script to the eligible participants who were volunteers of pregnant women in the waiting room of metropolitan hospital in taiwan.

Eligibility criteria:
inclusion criteria: * subjects were pregnant from 13th to 28th weeks gestation with a singleton pregnancy * subjects were at the age over 20 * could speak and read chinese fluently * willing and be able to attend the education program * determined to have a vaginal birth exclusion criteria: * taking medication for diagnosing mental illness * with complicated or high-risk pregnancies
a novel approach for brain stimulation in severe stroke

Conditions: Stroke

Summary: the long-term goal of this project is to develop upper limb rehabilitation interventions that can be utilized for stroke survivors, specifically survivors with more severe limitations in use of their affected upper limb. this study will utilize a novel method of non-invasive brain stimulation in conjunction with upper limb training given for 12 visits over a period of 6 weeks. the study will include the following site visits: * eligibility screening and informed consent visit * an mri visit * two testing visits in which motor function of the upper limb and neurophysiology will be measured * 12 intervention visits during which patients will receive upper limb training in conjunction with non-invasive brain stimulation * repeat testing of motor function of the upper limb and neurophysiology * repeat mri testing * a follow-up visit completed 3 months after the completion of interventions

in a pilot, randomized clinical trial, 24 stroke patients with moderate/severe impairments will receive non-invasive brain stimulation (repetitive transcranial magnetic stimulation or rtms) to one of two targets in the brain in conjunction with upper limb training for 2 days a week for 6 weeks. the primary outcome will be upper limb motor impairment, and secondary outcomes will be tests of functional abilities, proximal motor control, and patient-reported disability. associated neural mechanisms will also be studied using neurophysiological and functional connectivity mri techniques. damage to ipsilesional corticospinal pathways will be indexed with diffusion tensor imaging (dti).

Eligibility criteria:
inclusion criteria: * chronic phase (≥6 months) after index stroke * moderate or severely impaired (uefm ≤42) * have either extensive damage to ipsilesional pathways (mep-), or, have one of the following: less than 10 degrees active wrist extension, less than 10 degrees active thumb extension/abduction, less than 10 degrees active extension in at least 2 additional digits (i.e. will not meet minimum constraint-induced movement therapy \[cimt\] criteria). * medically stable exclusion criteria: * cerebellar stroke * brainstem stroke * bilateral strokes affecting sensorimotor structures * severe cognitive impairment * substantially elevated tone/spasticity in wrist/hand (modified ashworth scale \>3) * severe contracture * participation in outpatient or botox therapy within 2 months * exclusion criteria for tms and mri (metal implant in head, h/o seizures, alcohol or substance abuse, intake of medications contraindicated with tms, cardiac pacemaker or programmable implant).

Keywords: stroke brain stimulation tms upper limb mri cva rehabilitation
a psychoeducational intervention for stroke family caregivers

Conditions: Stroke

Summary: this is a randomized controlled trial with a 3-month psychoeducational program as intervention, followed by a 3 month observational period. the purpose of this study was to examine whether a psychoeducational program focusing on equipping caregivers with problem-solving skills would improve caregiver's problem-solving abilities, their psychological responses and caregiving resources, and would minimize the use of health and social services among stroke survivors.


Eligibility criteria:
inclusion criteria (caregiver): * family member of stroke survivor * chinese adult * live with stroke survivors * primary caregiver * being able to communicate with the researcher inclusion criteria (stroke survivor): * chinese adult with diagnosis of stroke * live at home after discharge * being able to understand and to give consent exclusion criteria (caregiver and stroke survivor): * history of self-reported doctor-diagnosed psychiatric illness * (stroke survivor): being mild to totally independent

Keywords: caregiver stroke psychoeducation problem-solving
efficacy and safety of astaxanthin in volunteer with refraction errors

Conditions: Refractive Errors

Summary: this study will investigate efficacy and safety of astaxanthin in 180 volunteers with refraction errors. visual test, skin test, liver function test, renal function test, and adverse event will be evaluated before and after taking astaxanthin for 1 and 2 months.

this study will investigate efficacy and safety of astaxanthin in 180 volunteers with refraction errors. they will divided into 3 groups which are astaxanthin 4 mg group , astaxanthin 6 mg group, and placebo group. they will take the sample 1 capsule once daily for 2 months. visual test, skin test, liver function test, renal function test, and adverse event will be evaluated before and after taking the sample for 1 and 2 months.

Eligibility criteria:
inclusion criteria: * age 18-65 years * refraction errors, dry eye, or blurred vision * have a willingness to participate in the study exclusion criteria: * uncontrolled disease * have complications during the study * have astaxanthin more than 2 weeks * allergic to astaxanthin, seafood, or seaweed * osteoporosis or thyroid disease * immunodeficiency or taking immunosuppressants * liver and kidney diseases * a person with a brain disorder, vision or hearing unusual * pregnancy or lactation * cannot follow the protocol * during participated in other studies