Kornimate/medical-research-clean huggingface dataset:
standard versus advanced antimicrobial dressing containing ionic silver following colorectal cancer surgery

Conditions: Colorectal Cancer

Summary: the purpose of this study is to evaluate the efficacy of treatment with hydrofibre dressing in comparison with the efficacy of standard dressing in terms of prevalence of surgical site infections (ssi) in patients who underwent colorectal resection for malignancy.


Eligibility criteria:
inclusion criteria: * patients bearing solid tumours who are candidate to open radical surgery for colorectal cancer (histology proven) * age 18-75 * informed signed consent * performance status 0-2 (according to ecog score) * platelets \> 50.000/mm3 * prothrombin time (quick) \> 60% * white blood cells \> 2500/mm3 * life expectancy \> 3 months exclusion criteria: * intestinal obstruction * severe intestinal bleeding requiring blood transfusion * age under 18 or over 75 * severe hepatic failure (ascites, portal hypertension, jaundice or encephalopathy) * renal failure (hemodialysis, creatinin \> 2.5 mg/dl) * active infections * coagulopathy * inability to give an informed consent * known allergies to dressing components

Keywords: surgical site infections (ssi) advanced antimicrobial dressing and clean surgery hydrofibre dressing
application of left colic artery preservation, anastomotic reinforcing sutures and transanal tube in robotic low anterior resection

Conditions: Rectal Cancer

Summary: the purpose of this study is to evaluate the results of combined application of left colic artery preservation, anastomotic reinforcing sutures and postoperative transanal tube placement in robotic low anterior resection for rectal cancer.

combined application of left colic artery preservation, anastomotic reinforcing sutures and postoperative transanal tube placement in robotic low anterior resection for rectal cancer

Eligibility criteria:
inclusion criteria: * clinical diagnosis of low rectal cancer; low rectal cancer was defined by the presence of the inferior pole of the tumor below the peritoneal reflection (in 11 cm from the anal margin) * primary tumor has undergone histologically comfirmed rectal adenocarcinoma * together with clinical or radiological evidence of stage ii (t3-4, n0, m0) or stage iii (t1-4, n1-2, m0) disease (according to the 2016 revision of the international union against cancer primary tumor, regional nodes, metastasis (tnm) staging system) * performance status (ecog) 0\~1 * adequate hematological function: neutrophils≥1.5 x109/l and platelet count≥100 x109/l; hemoglobin (hb) ≥9g/dl (within 1 week prior to randomization) * adequate hepatic and renal function: serum bilirubin≤1.5 x upper limit of normal (uln), alkaline phosphatase ≤5x uln, and serum transaminase (either primary tumor, regional nodes, metastasis (ast) or alt) ≤ 5 x uln(within 1 week prior to randomization); * written informed consent for participation in the trial. exclusion criteria: * body mass index (bmi) more than 30 kg/m2 * serious pre-operative comorbidity, including cardiovascular disease (coronary arteriosclerosis, arrhythmia, heart failure), pulmonary dysfunction (lung emphysema, obstructive lung disease), liver insufficiency (child-pugh b or c), renal insufficiency (serum creatinine \>2.0 mg/dl), and arterial circulation disturbance (occlusion of arterial vessels of limb in patient's history * history of accepting abdominal surgery

Keywords: low rectal cancer robotic surgery anastomotic leak
covid-19 disease and coagulopathy: assessment of clotting factor levels in patients with sars-cov-2 infection

Conditions: SARS-COV2 Infection; COVID-19 Disease; Hospitalized Patients

Summary: effect of covid-19 disease in clotting factors levels in hospitalized patients

effect of covid-19 disease in clotting factors levels in hospitalized patients positive for sars-cov2 infection. association between clotting factors levels and disease severity,morbidity and mortality in these patients. effect of anticoagulant therapy in the clotting factors' levels in these patients

Eligibility criteria:
inclusion criteria: * age\> 18 * singed informed consent form * positive pcr test for sars-cov2 infection * findings in cxr or ct of the lungs consistent with infection of lower respiratory tract exclusion criteria: * age\<18 * denial to provide informed consent form * history of malignancy * prior use of anticoagulant therapy * prior use of steroids longer than 14 days * lactation-pregnancy
effectivity of laparoscopic inguinal hernia repair (tapp) in daily clinical practice - early and long-term results

Conditions: Unilateral Inguinal Hernia With Gangrene and Obstruction

Summary: the effectiveness of laparoscopic inguinal hernia repair still remains unclear. during a one year period a total of 1208 inguinal hernias in 952 patients were consecutively operated using the laparoscopic technique by a total of 11 general surgeons in daily clinical routine. laparoscopic hernia repair in the tapp technique seems to have the potential to become the standard procedure in inguinal hernia repair in future.

objective: hernia repair is the most frequent operation in general surgery worldwide, but about 25 years after the advent of minimal invasive surgical techniques the effectiveness of laparoscopic inguinal hernia repair still remains unclear. methods: all patients admitted to the hospital for surgery of an inguinal hernia during a one year period were prospectively documented and included in a follow-up study. the follow-up was performed at least 5 years after surgery and consisted of a clinical examination, ultrasound investigation and a questionnaire.

Eligibility criteria:
inclusion criteria: * all patients fit for general anesthesia and presenting an inguinal hernia. exclusion criteria: * not fit for general anesthesia, young age (\>21 years), not wanting a mesh.

Keywords: inguinal hernia repair laparoscopic inguinal hernia repair tapp
evaluation of curexcell® in treating chronic venous leg ulcers

Conditions: Chronic Venous Leg Ulcers

Summary: the primary objective is to evaluate the clinical benefit of curexcell® as adjunct to standard of care in the treatment of chronic venous leg ulcers. curexcell® is a cell based therapy, containing activated homologous white blood cells prepared from donated healthy whole blood. a total of 252 patients will be randomized to receive either curexcell® or placebo.


Eligibility criteria:
inclusion criteria: * ankle brachial pressure index (abi) ≥ 0.80 * venous insufficiency confirmed by duplex doppler ultrasound * presence of a venous leg ulcer, unresponsive to standard of care treatment for at least 4 weeks and between ≥ 1 cm2 and ≤ 17.1 cm2 at screening; and between ≥ 1 cm2 and ≤ 12cm2 at the baseline visit exclusion criteria: * target ulcer has decreased \>30% in size from screening to baseline * documented history of osteomyelitis at the target ulcer location within 6 months preceding the baseline visit. * patients who are unable to tolerate multi-layer compression therapy. * ulcer, which in the opinion of the investigator is suspicious for cancer. * any malignancy within the past 5 years, excluding successfully treated basal cell carcinoma or squamous cell carcinoma without evidence of metastases. * history of radiation at the target ulcer site in previous 12 months prior to baseline visit. * patients with clinically significant claudication * current sepsis * patients with known history of significantly compromised immunity for any reason including radiation therapy, chemotherapy or hiv

Keywords: chronic ulcers venous ulcers
adaptation of a behavioral activation treatment to treat depression in autistic adults

Conditions: Autism Spectrum Disorder; Depression; Depressive Symptoms

Summary: the present study aims to adapt and evaluate the feasibility of the beatit behavioral activation intervention for people with intellectual disabilities and low mood to be implemented with autistic individuals, with and without intellectual disabilities.

the study has two specific aims: 1. adapt beatit materials for use with autistic adults with and without intellectual disability (id). focus groups engaging key stakeholders will inform the adaptation of beatit for autistic adults (i.e., beatit-asd). a stakeholder advisory team will provide input through the duration of the study. 2. evaluate the feasibility, acceptability, and preliminary efficacy of beatit-asd for autistic adults. this includes examining if the data demonstrate the feasibility and acceptability of the beatit-asd program for autistic adults and provide preliminary evidence for behavioral change (i.e., increased engagement in meaningful activities and reduced depressive symptoms). data will demonstrate the feasibility and acceptability of the adapted beatit intervention for autistic adults and provide preliminary evidence for reduction of depression symptoms via regulation of routines and achievement of meaningful goals.

Eligibility criteria:
inclusion criteria: 1. have a confirmed diagnosis of autism spectrum disorders (asd) 2. have a best estimate diagnosis of clinically significant depressive symptoms by the study team. this will be based on dsm-5 criteria or dm-id (diagnostic manual - intellectual disability). 3. have a support person willing to participate 4. live in new jersey or new york, or be within travel distance to rutgers university 5. half of participants will have a best estimate diagnosis of mild to moderate intellectual disability and half will not have intellectual disability. this will be based on participant cognitive assessment and self and/or supporter report of adaptive function during the baseline visit. exclusion criteria: 1. are unable to speak and understand english fluently (because the instruments being investigated are currently only validated in english and the focus group and intervention will be delivered in english). 2. are currently enrolled in another behavioral therapy or psychotherapy targeting depression. participants will not be excluded if they are currently taking medication.

Keywords: behavioral activation
high risk screen of childhood late-onset pompe disease in pediatric outpatient clinics

Conditions: Pompe Disease

Summary: establish of high-risk screening criteria to earlier identify possible childhood lopd for early treatment and better prognosis. therefore, validation of the high-risk screening criteria for childhood lopd will be critical for identifying children of lopd in taiwan.


Eligibility criteria:
inclusion criteria: * children who are \>1 year and \< 18 year of age from pediatric neurology, pediatric orthopedics and pediatric rehabilitation in ntuh exclusion criteria: * children who have been diagnosed as specific neuromuscular disorders.
assessment of arthroscopy in patients undergoing wrist fracture

Conditions: Wrist Injuries

Summary: the use of arthroscopy with the surgery of wrist fractures has a great health and economic impact (prolongs the time of surgery, requires adequately trained personnel, increases the time and surgical expenses and the risk of complications, however, in return ameliorate the prognosis and improves the functional recovery). there are few clinical trials showing a sufficient level of evidence in comparing the results of the surgical treatment of these fractures with volar plate and added arthroscopy so it is necessary to perform a clinical trial with an appropriate design and a sufficient sample size to elucidate the usefulness of arthroscopy in wrist fractures. therefore, the investigators want to perform an open and controlled clinical trial to adequately analyze the role of arthroscopy in the surgical treatment of wrist fractures in the investigators hospitals. the main objective of the study is to probe the arthroscopy effectiveness in the functionality of the injured wrist by prwe (a questionnaire assessing pain and wrist function) between the treatment groups of the trial at 12 months after surgery and for this the investigators plan a phase iv multicenter clinical trial.


Eligibility criteria:
inclusion criteria: * informed consent * patients able to read and understand the same consent. * patients over 18 years * broken wrist surgery with criteria based on the following criteria (must meet all): * patients functionally independent, ie, they can make the purchase without help, categorized according mackenney or patients who require assisted support by crutches / walker for walking. * radiographic unacceptable reduction after 1 attempted closed reduction in the er, defined as: 1. dorsal angulation\> 0 ° 2. ulnar variance\> 3mm postreduction. 3. step articular\> 1mm (20) 4. radial inclination \<15 ° * patients with unstable fracture. exclusion criteria: * type iii open fractures of gustilo and anderson. * bilateral fractures (not acceptable include more than one doll per patient for the analysis of the variables in the study, always choosing the wrist of the dominant hand). * fractures associated ipsilateral upper limb affection (except distal ulnar fracture). * fracture or serious injury prior ipsilateral wrist. * medical criteria that contraindicate surgery. * patients with low functional demand, categorized as dependent as mackenney, ie, they need help to go shopping and do not require assisted support by crutches / walker for walking. * patients with tumor lesions secondary processes (eg osteosarcoma, prostate cancer, breast cancer, multiple myeloma), congenital metabolic (eg osteogenesis imperfecta) and others involving themselves poor prognosis associated with disease. * women with suspected pregnancy or pregnancy can not participate in this clinical trial because the collection of monitoring data is expected performing radiographic examinations, in case of pregnancy, would be contraindicated.
clinical evaluation of a restorative glass ionomer and a composite resin for the restoration

Conditions: Tooth Disease

Summary: the clinical performances of a restorative glass ionomer and a composite resin will be compared in the restoration of non-carious cervical lesions (nccls) at patients with systemic diseases. after recruiting participants with at least 2 nccls and at least one systemic disease, all restorations will be placed by a single clinician. all lesions will be cleaned before restoring. nccls will be divided into two groups: a conventional restorative glass ionomer cement \[fuji bulk (gc, tokyo japan) (fb)\] and a posterior composite resin \[g-ænial posterior (gc, tokyo japan) (gp)\] all restorative procedures will be conducted according to manufacturers' instructions. restorations will be scored using modified united states public health service (usphs) criteria after a week (baseline) 6, 12, 24, 36 and 48 months. descriptive statistics will be performed using chi-square tests.


Eligibility criteria:
inclusion criteria: patients with at least one systemic disease such as hypertension, cancer in remission after chemotherapy or radiotherapy, diabetes mellitus, hemophilia, heart disease, coronary artery disease, rheumatoid arthritis, chronic obstructive pulmonary disease, lupus eritematozus. patients using medications for hypertension, diabetes mellitus, hemophilia, heart disease, coronary artery disease, rheumatoid arthritis, chronic obstructive pulmonary disease, lupus eritematozus. patients who are able to attend recall appointments. age greater than 18 years who had at least one systemic disease at least two nccls needed to be restored. at least 20 teeth in occlusion. exclusion criteria: non-vital teeth mobility of teeth severe periodontal disease heavy bruxism habit

Keywords: non-caries cervical lesions glass ionomer composite resin
piers and bis, sfit:pigf, adrenomedullin

Conditions: Eclampsia

Summary: pre-eclampsia, more than being proteinuric gestational hypertension alone, is a state of exaggerated systemic inflammation and remains a leading direct cause of maternal morbidity and mortality worldwide.1 standardization of antenatal and postnatal assessment and surveillance of pre-eclampsia with protocols that recognize the systemic inflammatory model of preeclampsia have been associated with reduced maternal morbidity.

background: pre-eclampsia, more than being proteinuric gestational hypertension alone, is a state of exaggerated systemic inflammation and remains a leading direct cause of maternal morbidity and mortality worldwide.1 standardization of antenatal and postnatal assessment and surveillance of pre-eclampsia with protocols that recognize the systemic inflammatory model of preeclampsia have been associated with reduced maternal morbidity.2 to quantitatively asses electroencephalography (eeg) mental involvement in pre-eclampsia is still time consuming and not always readily available. piers was developed and internally validate as a pre-eclampsia outcome prediction model- (preeclampsia integrated estimate of risk) model.3 the purpose of our study was to evaluate the discriminative power of the bispectral index (bis), biomarkers sfit (soluble fms-like tyrosine kinase): pigf (placental growth factor) ratio,4 and adrenomedullin mortality risk stratifier,5 to classify the degree and progression of pre-eclampsia. methods: in 24 patients with eclampsia or pre-eclampsia investigators will use an artefact-free 20-min mean bis value, as well as biomarkers sfit (soluble fms-like tyrosine kinase): pigf (placental growth factor) ratio and adrenomedullin mortality risk stratifier to classify the degree of pre-eclampsia correlated the piers pre-eclampsia risk assessment piers percentage (http://piers.cfri.ca/pierscalculatorh.aspx) will be calculated from patients' clinical and laboratory findings documented in their charts, compared with 24 pregnant patients without eclampsia or pre-eclampsia.

Eligibility criteria:
inclusion criteria 1. pregnancy at any stage (3 trimesters) 2. eclampsia (frank eclampsia) will be the crux of the study 3. pre-eclampsia that is suspected will end up with frank eclampsia exclusion criteria: 1. any neurological conditions that can alter the electroencephalography like epilepsy 2. any medical conditions that can alter the electroencephalography like hypoglycemia
clinical efficacy of iomt-based exercise program for the elderly

Conditions: Lower Back Pain; Knee Osteoarthritis

Summary: the purpose of this study is to evaluate the efficacy of internet of medical things (iomt) based home exercise programs for the elderly with degenerative knee arthritis or chronic low back pain.

this study presents the protocol of a prospective, single-center, single-blinded, two-armed randomized controlled trial. the investigators plan to recruit patients over 65 years of age with degenerative knee arthritis or chronic low back pain. patients will be randomly divided into two groups with 1:1 allocation. the intervention group will receive 6 weeks of the iot-based home exercise program. the iomt-based home exercise program is implemented to the patients via a smartphone application. the home exercise program sets the exercise intensity to 3 levels (low, medium, and high) according to the disease and consists of 2 stretches, 3 strengthening and/or functional exercises, and a cool-down exercise (figure 1). the exercise group applies a daily home exercise program (30min/day, 7days/week for 6 weeks). the activity detector records the amount of activity and the speed of movement within the home. the door sensor detects the enter and exit and records the number of outings. the pillbox notifies subjects to take the medication time. the smart-care phone provides emergency call and guardian connection services. the body composition analyzer measures body mass index, fat, and muscle mass. the primary outcome in patients with degenerative knee arthritis is western ontario and mcmaster universities osteoarthritis. and the primary outcome in patients with chronic low back pain is oswestry disability index. the secondary outcomes are numeric rating scale for pain, 36-item short-form health survey, geriatric depression scale, timed-up and go test, and 30s chair sit and stand. the investigators evaluate primary and secondary outcomes before and after the home exercise programs.

Eligibility criteria:
inclusion criteria: * knee pain for more than 3months, kellgren-lawrence grade 2 or higher * low back pain for more than 3months * a person who underdtands the exercise program * numeric rating scale of 4 or higher exclusion criteria: * history of knee surgery * systemic inflammatary disease * history of polyneuropathy * history of stroke * severe heart failure * chronic obstructive pulmonary disease
effects of oriental music on preterm infants

Conditions: Premature; Behavior, Child

Summary: the goal of this study is to explore the effect of oriental music on premature infants' physiological and behavioral parameters during their hospital stay in the nicu.

music exposure during care of preterm infants is the subject of increasing research. many studies have shown positive impact of music exposure such as classical western music, lullabies or quran on pain and physiological parameters of preterm infants in a neonatal intensive care unit (nicu) setting. no such study have explored the effect of oriental music which is the main popular music listened to in the levant and middle east and north afrika (mena) region. we aim in this study to find out if the oriental music exposure in preterm infants improves babies' heart rate variability, physiological parameters and behavior state during their nicu stay.

Eligibility criteria:
inclusion criteria: * clinically stable infants born between 28 and 366/7 weeks of gestation and ≥31 weeks post menstrual age (pma). * infants planned to stay in the nicu for at least 2 weeks at the time of enrollment. exclusion criteria: * congenital anomaly affecting heart rate and hearing, significant brain insult (such as severe or moderate hypoxic ischemic encephalopathy, intraventricular hemorrhage (ivh) grade 3 or 4 or periventricular leukomalacia) that might affect the neurodevelopmental outcome. * receiving medications that might interfere with heart rate and reaction to music exposure such as midazolam or morphine.

Keywords: music therapy premature infant heart rate variability behavior state
clinical trial to evaluate the efficacy and safety of adhesion barrier mediclore versus no treatment in patients with total thyroidectomy

Conditions: Patients With Thyroidectomy (Scheduled)

Summary: a randomized, single-blind, multi-center, phase iii clinical trial to evaluate the efficacy and safety of adhesion barrier mediclore versus no treatment in patients with total thyroidectomy


Eligibility criteria:
inclusion criteria: * written informed consent * male or female at least 20 years of age * patients without clinically significant lab * patients scheduled for thyroidectomy exclusion criteria: * another clinical trials within 1 month * history of previous surgery on same position * anticoagulant, general steroids within a week from surgery * immunosuppression or autoimmune disease * general or local infection * serious diseases (heart failure, renal failure, liver failure, uncontrolled hypertension, diabetes mellitus, coagulation deficiencies) * incompatible medications * history of drug or alcohol abuse, mental disorder * pregnant or lactating women and fertile women who is not using proper contraceptive method * history of esophagus diseases * keloid symptoms