Kornimate/medical-research-clean huggingface dataset:
a study of bevacizumab in previously untreated extensive-stage small cell lung cancer (salute)

Conditions: Small Cell Lung Cancer

Summary: this is a placebo-controlled, double-blind, multicenter, randomized study for preliminary evaluation of the efficacy and safety of combining bevacizumab with cisplatin (or carboplatin) and etoposide in patients with previously untreated extensive-stage small cell lung cancer (sclc).


Eligibility criteria:
inclusion criteria: * histologically or cytologically documented small cell carcinoma of the bronchus, classified as extensive-stage disease * measurable disease or lesions * eastern cooperative oncology group (ecog) performance status of 0, 1, or 2 exclusion criteria: * life expectancy of \< 12 weeks * current, recent, or planned participation in another experimental drug study * ongoing or active infection * active malignancy other than sclc or superficial basal/squamous cell carcinoma within the previous 5 years * prior systemic therapy, radiation therapy, or surgery for sclc * inadequate bone marrow function, renal function, or hepatic function * serum sodium of \< 120 mg/dl * inadequately controlled hypertension * history of hypertensive crisis or hypertensive encephalopathy * new york heart association class ii or greater congestive heart failure * history of myocardial infarction or unstable angina within 6 months prior to study enrollment * history of stroke or transient ischemic attack within 6 months prior to study enrollment * known central nervous system disease, except for brain metastases treated with whole-brain radiotherapy * significant vascular disease or recent peripheral arterial thrombosis within 6 months prior to study enrollment * history of hemoptysis within 4 weeks prior to study enrollment * evidence of bleeding diathesis or coagulopathy in the absence of therapeutic anticoagulation * major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to study enrollment or anticipation of a need for a major surgical procedure during the course of the study * core biopsy or other minor surgical procedure, including placement of a vascular access device, within 7 days prior to day 1 * history of abdominal fistula or gastrointestinal perforation within 6 months prior to study enrollment * serious, non-healing wound, active ulcer, or untreated bone fracture * known hypersensitivity to any component of bevacizumab * pregnant (positive pregnancy test) or lactating

Keywords: sclc salute lung cancer avastin
effects of stretch-shortening cycle exercises postural control in down syndrome

Conditions: Down Syndrome

Summary: to investigate the effect of a 3-month, trampoline-based stretch-shortening cycle (ssc) exercises on muscle strength and postural control in children with down syndrome.

a variety of physical therapy techniques are being used to improve lower limb muscle strength and postural control in children with down syndrome including, but not limited to, progressive resistance training, hippotherapy, aquatic therapy, and isokinetic strength training. stretch-shortening (ssc) exercises-also referred to as plyometric exercises, is a traditional form of resistance training that involves three-phase muscle contraction during dynamic movements (like jumping and hopping), where the muscle moves rapidly through the eccentric, isometric, and concentric phases.

Eligibility criteria:
inclusion criteria: * age between 7 and 9 years. * able to follow one step motor commands. * independent ambulators. * not suffering from atlantoaxial joint instability as reported from their medical files. exclusion criteria: * children with un-corrected cardiac anomalies. * children with un-corrected vision or hearing loss. * children with un-corrected pulmonary disorders. * children with un-corrected neurological signs as epilepsy. * children who had a history of musculoskeletal surgery in the lower extremities through the past year.
open versus close chain exercise effects with lifestyle modification and education in knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: a randomized clinical trial will be conducted in gujranwala and 24 patients with grade 3 knee oa will be recruited. after consent, patients will be randomly allocated into 2 groups by lottery method. group a will do close kinetic chain exercises, including static cycling, lifestyle modification, and patient education. group b will do open kinetic chain exercises including quadriceps drills with lifestyle modification and patient education. a total duration of 12 weeks with 3 sessions per week will be given. outcome measures assessment will be done at 0 weeks, 4 weeks, 8 weeks, and 12 weeks.

osteoarthritis is a clinical syndrome characterized by joint pain, varying degrees of functional impairment, and a poor quality of life and in 21st century it is predicted that the number of persons over 65 would double placing a heavy burden on healthcare systems and caregivers' resources. for individuals with knee oa, open kinetic chain (okc) and closed kinetic chain (ckc) exercises have been recommended thus far. the distal segment of the body components can move freely during okc exercise since it is not bound, but remain static on the ground during ckc exercise. a single-blinded randomized clinical trial will be conducted at al-raee trust hospital gujranwala and 24 patients of both genders and age of 50-70 years with grade 3 knee oa (according to kellgren and lawrence classification system based on plain x-rays) will be recruited. after taking written consent, patients will be randomly allocated into 2 groups by lottery method. group a will be treated with close kinetic chain exercises including static cycling with lifestyle modification and patient's education and group b will be treated with open kinetic chain exercises including quadriceps drill with lifestyle modification and patient's education about 30 minutes per session including 10 min of walking as a warm up for total duration of 12 weeks with 3 sessions per week. outcome measures such as pain, disability and health status will be assessed by nprs, womac and oakhqol respectively. assessment will be done by therapist at 0 week, 4 weeks, 8 weeks and 12 weeks.

Eligibility criteria:
inclusion criteria: * • both genders * with grade 3 of knee osteoarthritis (kellgren-lawrence scoring) * mild-to-moderate pain on nprs * age 50-70 years old * available three times a week for over 3 months exclusion criteria: * • having knee surgery in the past 6 months * having acute symptomatic koa * having any muscular, joint or neurological conditions that affect lower limb function * conducting another structured exercise programme specifically for koa during this study period * having motor neuron disorders such as alzheimer's and parkinson's diseases.
multicenter database of patients with germ cell tumor

Conditions: Neoplasms, Germ Cell and Embryonal

Summary: retrospective and prospective cohort of patients with germ cell tumor in treatment.

the primary objective of this study is to create a multicenter database in order to characterize epidemiologically and clinicopathologically patients with germ cell tumor and evaluate the prognosis and clinical outcomes during cancer treatment.

Eligibility criteria:
inclusion criteria: * male patients with diagnosis of testicular, retroperitoneum or mediastinal primary tumor. * histological confirmation of germ cell tumor or clinical condition based on the elevation of tumor markers (afp, hcg e/ou dhl) associated to testicular mass or/and retroperitoneal lymphnode enlargement or/and mediastinal mass. * medical records of the disease and treatment exclusion criteria: * female patients diagnosed with ovary germ cell tumor * male patients diagnosed with germ cell tumor in other locations.
evaluation and detection of facial propionibacterium acnes bacteria and phage

Conditions: Acne

Summary: this multi-center, outpatient study will extract and evaluate the presence of facial p. acnes bacteria and phage strains using pore strips on up to 400 human subjects.

this multi-center, outpatient study will extract and evaluate the presence of facial p. acnes bacteria and phage strains using pore strips on up to 400 human subjects. an additional p. acnes visual detection method (visiopor ® pp34n) will be used in this study as per pi decision to explore whether there is a correlation between p. acnes bacterial presence and fluorescent signal.

Eligibility criteria:
inclusion criteria: 1. adults between 14 to 50 years of age inclusive at the time of signing the informed consent 2. able to provide written informed consent 3. subjects who are willing to undergo pore strip treatment using the cosmetically acceptable pore strip product 4. subjects who are willing to provide comprehensive demographic data using questionnaires exclusion criteria: 1. unwilling or unable to follow the procedures outlined in the protocol 2. subjects treated with isotretinoin or tretinion during the 6 months prior to visit 1 3. subjects treated with immunosuppressant agents 4. pregnant subjects
efficacy of pre- and post-operative oral dextromethorphan

Conditions: Efficacy of Dextromethorphan; Morphine Consumption; Pain

Summary: we studied the effect of dextromethorphan (dex), an n-methyl-d-aspartate antagonist, on analgesic consumption and pain scoring after abdominal hysterectomy. our aim was to compare the analgesic effectiveness and incidence of adverse side effects of oral dex with placebo (p)

one hundred patients were randomized to two groups. group dex was given 30 mg tablets of oral dextromethorphan with their pre-medication and three more times in the first 24 hours after surgery. group p received the placebo following the same schedule. post-operative analgesic requirements were assessed using a patient-controlled analgesia system. pain was assessed at rest using a visual analog scale in the post anesthetic care unit(pacu), 6 and 24 hours after surgery.

Eligibility criteria:
inclusion criteria: * women aged between 30 and 60, with an asa physical status of i or ii, undergoing elective total abdominal hysterectomy under general anesthesia. exclusion criteria: * women with a history of significant renal or hepatic impairment, allergy to any of the study medications, antitussive or nsaid use (48 hours or 1 week, respectively) before surgery, chronic pain and regular analgesic use, were excluded. patients taking medications that could interact with dextromethorphan, including quinidine, flecainide, mexiletine, fluoxetine, amitriptyline, nortriptyline, and propafenone

Keywords: nmdareceptor antagonist, dextromethorphan pain, post-operative opioid consumption, morphine
regional analgesia techniques for effective recovery to coronary artery bypass surgeries: a retrospecti̇ve study in a single center experience

Conditions: Postoperative Pain

Summary: background pain after cardiac surgery is both multifocal and multifactorial. sternotomy, sternal retraction, internal mammary dissection, posterior rib dislocation or fracture, possible brachial plexus injury, and mediastinal and pleural drains contribute to pain experienced in the immediate postoperative period. ineffective pain management can cause systemic and pulmonary complications and significant cardiac consequences. methods this study was conducted to compare the effectiveness of regional anesthesia techniques for perioperative pain management in cardiac surgery patients at our clinic. the effects of analgesic methods, in terms of contributing to recovery, have been examined.

this study was approved by the koç university clinical research ethics committee (2021.464.irb1.131); patients who underwent coronary artery bypass grafting (cabg) surgery at the vkv american hospital between january 2015 and may 2020 were reviewed retrospectively. patients with a history of cerebrovascular events, scheduled carotid surgery, or emergency cabg surgery were excluded from the study. demographic data from the preoperative evaluation forms and operation types from the surgery reports were recorded. intraoperative anesthesia follow-up forms were assessed if regional anesthesia was used, and the type and extent of opioids during the operation were examined. the postoperative transfer forms were examined to the cardiovascular intensive care unit (cicu), intensive care follow-up forms, and service ward record follow-up forms. pain scores (nrs) during rest and coughing, vital signs, mobilization, and the start of respiratory exercises were recorded for postoperative respiratory complications.

Eligibility criteria:
inclusion criteria: * who underwent coronary artery bypass grafting (cabg) surgery at the vkv american hospital between january 2015 and may 2020 were reviewed retrospectively exclusion criteria: * history of cerebrovascular event * history of alzheimer's and dementia * inadequate cognitive functions * history of chronic pain * long-term opioid therapy
impact of pax good behavior game on elementary school students in estonia

Conditions: Mental Health Wellness 1; Mental Disorders

Summary: the aim of this study is to measure the impact of the intervention (pax gbg) in estonian-language 1st grade classrooms on students' mental health and behaviour, and teacher's self-efficacy.

2-year, matched-pair, cluster-randomized controlled trial with a intervention and wait-list control arm is conducted during school years 2016/17 and 2017/18. 42 volunteering schools were matched to pairs. one school in each pair was randomly selected to receive the pax gbg or continue their normal activities without intervention. after a post-test assessment in spring 2018 the control group teachers are trained and supported to implement pax gbg.

Eligibility criteria:
inclusion criteria: all schools with first grade classrooms and estonian-language as instruction language in estonia were qualified to take part of the study if they did fit the inclusion criteria. schools were suitable to participate if they: * had equal to or more than 13 pupils in the first grade classroom in 2016/17 school term; * did not implement any other evidence-based program in basic school stage 1 (grades 1-3), (for example kiva bullying prevention program); * did not already implement pax gbg; * had at least one first grade teacher who volunteers to participate for the whole study period of two years. exclusion criteria: * schools for children with special educational needs and schools with russian language as instruction language were excluded. * schools with single-sex classrooms were excluded.
hyperthyroidism as a potential predictive of worse outcome of renal graft

Conditions: Kidney Diseases; Kidney Transplant; Hyperthyroidism

Summary: the objectives of the study are: to research the association, if any, between the occurrence of thyroid function changes in the immediate post-transplant period and the prognosis of the transplant itself; identify any risk factors for the occurrence of thyroid disorders in the immediate post-transplant period.

kidney transplant patients are by definition affected by mrc, regardless of egfr. however, at the same time, several factors make them a unique category with distant characteristics from non-kidney transplant mrc patients. immunosuppressant and corticosteroid therapy could affect a variety of systems, including the pituitary-thyroid-kidney axis. mtor inhibitors, for example, would result in increased iodine uptake in tsh-stimulated thyrocytes. corticosteroids, on the other hand, inhibit the conversion of t4 to t3 and inhibit the tsh production in a dose-dependent manner, and this activity could contribute to the low t3 syndrome that some sturi repot in the phase immediately following kidney transplantation. in addition, abrupt changes in the serum concentration of thyroid hormones in the immediate post kidney transplantation could be influenced by the stress surgery related to the surgery itself and by exposure to iodinated agents (antiseptics and iodinated contrast medium). the objectives of the study are: 1. to research the association, if any, between the occurrence of thyroid function changes in the immediate post-transplant period and the prognosis of the transplant itself in terms of: * renal function three months after transplantation. * medical complications in the post-transplant period (from surgery to patient discharge) * patient survival at three months after transplantation. 2. identify any risk factors for the occurrence of thyroid disorders in the immediate post-transplant period. during the past 5 years at the transplant center of the nephrology ou, dialysis, transplantation of our hospital, 579 kidney transplants have been performed with an average of about 115 transplants per year. it is therefore estimated for our study a sample size of about 100 patients, given the need to meet the inclusion criteria.

Eligibility criteria:
inclusion criteria: * subjects transplanted at our center; * subjects whose 3-month follow-up is available; * age ≥18 years; * availability of clinical and laboratory data regarding thyroid function trends in the immediate post-transplant period (within 30 days after transplantation); * subjects giving informed consent to participate. exclusion criteria: * none.

Keywords: hyperthyroidism kidney diseases
effects antioxidants supplementation on muscular function patients facioscapulohumeral dystrophy (fshd)

Conditions: Facioscapulohumeral Muscular Dystrophy

Summary: on the basis of published data and the investigators' results indicating that oxidative stress may contribute to the peripheral skeletal muscle dysfunction in patients with fshd, the investigators propose a study to test whether or not an antioxidant supplementation has a therapeutic interest for patients with fshd. their results have important implications for the successful implementation of rational antioxidant therapy in fshd in which cell loss could be linked to oxidative stress.

this study will compare the effect of the therapeutic interest of an antioxidant supplementation on the functional deficits and the molecular muscle abnormalities into two groups of patients affected by fshd, one treated with the antioxidant supplementation during 17 weeks. the antioxidant by capsule consisted of:vitamin e (400 mg /day), selenium (200 µg/day in the form of selenomethionine), vitamin c (500 mg/day), zinc (25 mg/day in the form of gluconate). the second one treated with a placebo during 17 weeks. patients will be assigned to intervention groups by chance, and neither physician, nor patient, will know which product is administrated (study in "double blind").

Eligibility criteria:
inclusion criteria: * fshd patients will be recruited on the basis of: * the number of repeat units (4 to 9) * fshd patients with a positive family history for fshd * not confined to a wheelchair * no smokers * no associated co-morbidity (cardiac or pulmonary disease, diabetes etc.) * no medications or nutritional supplementation (vitamins and/or antioxidants) at the time of the study * no hiv positive exclusion criteria: * no consent form

Keywords: fshd antioxidants oxidative stress muscle function quality of life activity (fshd;4q35)
i can move with purpose now! a pilot lifestyle intervention study in myeloproliferative neoplasm patients

Conditions: Myeloproliferative Disorders; Leukemia

Summary: the goal of this study is to see if patients with myeloproliferative disorders are able to successfully complete the cardiac lifestyle program(clp). the goal of the clp is to teach patients how to become more active and eat healthier foods. the name of the intervention used in this research study is: cardiac lifestyle program (a 12-week, tailored nutrition and physical activity program)

this is a single-arm, prospective pilot study that will enroll eligible myeloproliferative neoplasms (mpn) patients in a 12-week exercise and nutrition-based cardiac lifestyle program (clp). this research study is a feasibility study, which is the first time investigators are examining this exercise program in myeloproliferative disorder patients. study procedures include screening for eligibility, an in-clinic visit, questionnaires, program group classes, and blood work. participation in this research study is expected to last 12 weeks. it is expected that about 30 people will take part in this research study.

Eligibility criteria:
inclusion criteria: -≥18 years of age * diagnosed with an mpn by who 2016 criteria,22 including essential thrombocythemia (et), polycythemia vera (pv), prefibrotic myelofibrosis (pre-mf), myelofibrosis (mf), and mpn not otherwise specified (nos). within mf patients, only patients who are low or intermediate-1 risk by the dynamic international prognostic scoring system (dipss) are eligible.23 all risk groups are eligible for the remaining mpn subtypes. * eastern cooperative oncology group (ecog) performance status 0-1 * must have at least one cardiovascular risk factor including: body mass index (bmi) \>25 kg/m2, hypertension, hyperlipidemia, diabetes mellitus or pre-diabetes or metabolic syndrome, or any prior history of cardiovascular disease, transient ischemic attack, stroke, or peripheral vascular disease. patients not meeting any cardiovascular risk criteria must receive prior approval from the pi to participate in this study. exclusion criteria: -- mf patients with intermediate-2 or high-risk disease by dipss * ecog performance status \>2. * any injury or medical condition that would prohibit being able to safely perform exercise, as determined by the treating physician.

Keywords: myeloproliferative disorders leukemia
investigation of urinary biomarkers for the diagnosis of insulin resistance

Conditions: Insulin Resistance

Summary: the study aims at the identification and the quantification of urinary branched-chain amino acids (bcaas) by mass spectometry in healthy subjects and patients with insulin resistance and correlating urinary bcaas with homa index. blood and urine levels of bcaas will be correlated with homa index to assess and quantify insulin resistance. identification and quantification of urine bcaas by an innovative method based on synthetic biology will also be performed. correlations between mass spectometry and the innovative detection method of bcaas will be searched.

blood and urine samples will be collected in 330 persons to assess bcaas levels and correlate them with homa index. persons included will be: 110 persons with bmi\>27 and homa \>4 with no diabetes 110 persons with bmi\>27 and homa \< 4 with no diabetes 110 persons with bmi \< 27 and homa \<4 with no diabetes, including at least 50 men and 50 women, 30 aged 18-35, 30 aged 36-55, 30 aged 56-75. urine bcaas will be measured by both mass spectrometry and the innovative method based on synthetic biology.

Eligibility criteria:
inclusion criteria: * no diabetes * according to studied subpopulations: bmi\ 27 and homa\>4, bmi\>27 and homa\<4 exclusion criteria: * pregnancy or lactation * active or suspected chronic infection * treatment affecting insulin sensitivity

Keywords: insulin resistance