Kornimate/medical-research-clean huggingface dataset:
efficacy of external nasal nerve block in prevention of postoperative agitation following nasal surgeries

Conditions: Agitation States as Acute Reaction to Gross Stress

Summary: emergence agitation following general anaesthesia may lead to serious complications like self-extubation or removal of catheters, which can lead to hypoxia, aspiration pneumonia, bleeding or reoperation. nose surgery is associated with a higher incidence of emergence agitation. the investigators planned to evaluate the efficacy of external nasal nerve block in prevention of postoperative agitation following external nasal surgeries under general anesthesia(ga).


Eligibility criteria:
inclusion criteria: * 110 adult patients of asa physical status i and ii, * age 20-60 years, * scheduled for elective external nasal surgeries in which nasal packing on each side was used postoperatively for 24 hours. exclusion criteria: 1. history of uncontrolled hypertension, 2. ischemic or valvular heart disease, 3. use of mao inhibitors or adrenergic blocking drugs, 4. cognitive impairment, 5. patients taking antipsychotics, 6. renal insufficiency or liver dysfunction

Keywords: nasal surgery external nasal nerve block postoperative agitation
remote ischemic postconditioning during percutaneous coronary interventions

Conditions: Coronary Artery Disease

Summary: angioplasty is a commonly performed procedure for treating blockage of the blood vessels in the heart. although this procedure is usually successful, it is often accompanied by a small degree of damage to the heart (i.e., small heart attack). the purpose of this study is to find out if inflating a blood pressure cuff on the arm or the leg at the time of angioplasty for several minutes has a beneficial effect. patients will be assigned to one of three treatment groups: inflating blood pressure cuff on the arm, inflating blood pressure cuff on the leg and a control group.


Eligibility criteria:
inclusion criteria: * patients scheduled for pci exclusion criteria: * acute myocardial infarction * myocardial infarction or coronary bypass surgery during the last 4 weeks before pci * use of glyburide * heart failure (nyha iii/iv) * chronic inflammatory disease * severe renal impairment * significant peripheral vascular disease * unsuitable for use of an embolic protection device for pci to svg

Keywords: coronary artery disease pci postconditioning elective or urgent pci
a retrospective molecular epidemiology study in singapore patients with advanced non small cell lung cancer (nsclc) of adenocarcinoma histology to assess epidermal growth factor receptor (egfr) mutation status

Conditions: NSCLC

Summary: to determine egfr mutation status in patients with advanced stage adenocarcinoma nsclc. to determine the association between egfr mutation status and demographic data in advanced stage adenocarcinoma nsclc patients.


Eligibility criteria:
inclusion criteria: nil exclusion criteria: nil

Keywords: egfr mutation status in patients with advanced stage adenocarcinoma nsclc the association between egfr mutation status and demographic data in advanced stage adenocarcinoma nsclc patients.
the impact of mitotane therapy on serum free proteins in patients with adrenocortical carcinoma

Conditions: Adrenocortical Carcinoma

Summary: this work will evaluate the effects of mitotane treatment on serum protein concentrations in patients treated for acc with mitotane therapy and compare them to patients with an adrenal neoplasm and pregnant cohort. all of the individuals were treated at king's hospital between april 2019 and june 2020. proteins which will be evaluated during this study, include cbg and tbg.

background: adrenocortical carcinoma (acc) is a rare malignancy of the adrenal cortex. the annual incidence of acc is thought to be between 0.5-2.0 cases per million. adjunctive therapy with mitotane may be offered post- surgically to minimise risk of recurrence. aims: evaluate the effects of mitotane treatment on serum protein concentrations in patients treated for acc with mitotane therapy and compare to patients with an adrenal neoplasm and a pregnant cohort. patients were treated at king's hospital between april 2019 and june 2020. methods: cortisol, tft's acth, cbg, tbg and gonadotrophins will be measured during the same venepuncture using serum samples. spss v27 and graphpad prism v9.3.1 will be used for analysis and illustrations. thirty-five patients will be included, within acc with mitotane, adrenal neoplasm or pregnant groups. data will be tested for normality, described as mean± sd, compared using paired sample t-test with 5% p-value for significance and 95% confidence interval (ci).

Eligibility criteria:
inclusion criteria: an individual being investigated for a malignant neoplasm treated with mitotane or matched number of patients with adrenal neoplasm not treated with mitotane under the endocrinology team or a matched cohort of pregnant women. patients included in the analysis were seen in the period between april of 2019 and june 2020 at king's college hospital nhs foundation trust. - exclusion criteria: * patients not investigated for a malignant neoplasm/ adrenal neoplasm under the endocrinology team or were a matched cohort of pregnant women at king's college hospital nhs foundation trust during the period someone under the age of 18

Keywords: mitotane adrenocortical carcinoma acc serum free proteins cortisol binding globulin thyroid binding globulin
dietary adherence and cognitive function in older adults

Conditions: Cognitive Function; Mediterranean Diet; Dietary Approaches to Stop Hypertension; Elderly Population

Summary: this study aimed to evaluate the relationship between adherence to the mediterranean, dash, and mind diets and cognitive function in elderly individuals. data were collected from 1,027 participants aged 65 and older, using dietary assessment tools and the standardized mini mental test (smmt), and were analyzed with spss 26.

a total of 1027 elderly individuals aged 65 years and over were included in the study. demographic questionnaire and mediterranean diet adherence scale were administered to the individuals. adherence to the mediterranean-dash intervention for neurodegenerative delay (mind) diet was scored and food consumption was recorded for adherence to the dietary approaches to stop hypertension (dash) diet. standardised mini mental test (smmt) was used to assess mental status. data were analysed with spss 26 software.

Eligibility criteria:
inclusion criteria: 1. individuals aged 65 years and older. exclusion criteria: 1. individuals diagnosed with psychiatric or neurological diseases (e.g., dementia, alzheimer\&#39;s disease). 3. individuals with alcohol or drug addiction. 4. illiterate individuals.

Keywords: cognitive function mediterranean diet elderly health dash diet mind diet
effect of intravenous fluid supplementation on serum bilirubin and cardiorespiratory parameters in preterm infants during phototherapy

Conditions: Hyperbilirubinemia

Summary: the aim of the study was to evaluate the influence of a systematic extra intravenous fluid supplementation during phototherapy in comparison to a fluid supplementation due to short term demand in preterm infants.

60 preterm infants (ga ≤ 32 week) were assigned randomly to either receive a fluid supplementation due to short term demand (control group, n=30;) or a 20% extra fluid supplementation (study group, n=30) during intermediate phototherapy. collected data: * cardiorespiratory parameters(heart rate, blood pressure, sao2 and capillary refill time, breathing rate, temperature) and a pain score was completed at the first day of phototherapy * the maximum total serum bilirubin levels (tsb) within one week after onset of phototherapy

Eligibility criteria:
inclusion criteria: * hyperbilirubinemia exclusion criteria: * preterm infants \> 33 weeks of gestation

Keywords: preterm infants < 32 weeks of gestation
topical interferon alfa 2b and mitomycin c in conjunctival-corneal intraepithelial neoplasia

Conditions: Conjunctival Intraepithelial Neoplasia; Corneal Intraepithelial Neoplasia

Summary: the purpose of this study is to evaluate the therapeutic efficacy of interferon alfa 2b and topical mitomycin c in patients with diagnosis of conjunctival-corneal intraepithelial neoplasia.

the corneal and conjunctival intraepithelial neoplasia is the most common malignant tumor of the ocular surface. classic treatment is complete excision with safety margins, however, usually the edges are not sharp and difficult clinical differentiation between healthy areas that are not; to this treatment has joined him carrying out cryotherapy bedding and borders . despite this treatment the recurrence rate ranges from 9-52 %. antineoplastic drugs have been used either as adjuvant or primary treatment . among the drugs used the investigators have mitomycin c (mmc) and interferon alpha 2b (infα 2b). controlled clinical trial , single-blind , randomized . non-probability sampling of consecutive cases. patients will be assigned to treatment with mmc or infα2b periodic clinical evaluations and photos will be made. time of resolution, resistance and adverse effects will be determined. patients treated with mitomycin will be handled by cycles until resolution of the lesion, which according to previous studies is expected between 3 and 6 cycles (between half months and 3 months). patients managed with interferon will be treated for a period ranging from one month to 12 months according to clinical resolution of the lesion. both groups will be evaluated by at least one year after the resolution of the lesion to determine the presence of recurrences.

Eligibility criteria:
inclusion criteria: * patients with clinical diagnosis of corneal and conjunctival intraepithelial neoplasia (cin) with no history of ocular neoplasia exclusion criteria: * patients who did not agree to participate in the study. * patients with corneal abrasion * patients who have the diagnosis of cin, but are pregnant

Keywords: conjunctival-corneal intraepithelial neoplasia mitomycin c interferon alfa 2b
use of a hand-held digital cognitive aid in the early management of simulated war wounds.

Conditions: Combat Casualty Care

Summary: combat casualty care has proven to increase survival rate in military conflict by treating without delay the quickest-to-kill wounds. the french militaries are trained to the marche ryan acronym, an algorithm designed to help every soldiers provide simple treatment in order to bring the patient to the surgeon alive. our first study (max, lelaidier et al, bja 2017) clearly showed that the use of a digital cognitive aid in the hand of the leader significantly improves the management of anaesthesia \& intensive care emergencies (malignant hyperthermia, anaphylactic shock, acute toxicity of local anaesthetics, severe and symptomatic hyperkalaemia). the present study exclusively deals with the management of combat casualties with the same digital cognitive aid adapted for marche ryan algorithm.

in a first study (max, bja 2017, lelaidier et al) the investigators designed a digital cognitive aid (max for medical assistant expert) under the form of a smartphone application including 5 scenarios of anaesthesia and intensive care crises (malignant hyperthermia, anaphylactic shock, acute toxicity of local anaesthetics, severe and symptomatic hyperkalaemia, ventricular fibrillation), designed to be used in the hand of the leader managing the situations. technical and non-technical skills were improved in 4 out of 5 scenarios. combat casualties are dealt with a stereotyped management in the french army, and all soldiers learn the algorithm (acronym) designed for this purpose, the marche ryan. situations requiring the use of the marche ryan are extremely stressful (on the battlefield, performed by non-medical personal, often on a comrade). the present study exclusively deals with the management of combat casualties with the digital cognitive aid max adapted for marche ryan algorithm.

Eligibility criteria:
inclusion criteria: * soldiers * already trained in combat care level 2, under training for external operations. exclusion criteria: * none
evaluation of multi-modal supportive actions in outpatient cardiac rehabilitation in subjects with cardiovascular disease

Conditions: Evaluation of Multi-modal Supportive Actions in Outpatient Cardiac Rehabilitation in Subjects With Cardiovascular Disease

Summary: cariovascular diseases (cvd) are the most common cause of death worldwide with high micro- as well as macro-economic burden. several modifiable risk factors increase the probability of contracting a cve. these risk factors can be positively influenced by a cardiac rehabilitation measure (cr), which has been shown to reduce mortality in cvd patients and to reduce the economic burden. an increase in physical activity and performance are central goals in cr, as they have a positive effect on several cardiovascular risk factors and correlate strongly with a reduction in mortality in cvd patients. these goals can be achieved in most cvd patients but can only be achieved by a modification of lifestyle. in order to positively influence this lifestyle modification beyond the duration of the cr measure and thus in the long term, cr phase ii should begin as soon as the patient fulfils one of the well-defined inclusion criteria. cr phase ii can be carried out as an inpatient or outpatient procedure and depends on the patient's state of health, personal preference and availability of an outpatient cr facility in the vicinity of the patient. in the austrian healthcare system, inpatient cr and thus differs from other european countries. after completion of phase ii, the patient is offered an outpatient phase iii with weekly visits to the outpatient cr facility, so that lifestyle changes achieved at short notice can be sustainably maintained. for the secondary prevention of the cvd beyond the cr measure recommend international guidelines a physical activity of ≥ 150 min with moderate intensity or ≥ 60 to 75 min high intensity per week. the current study situation allows the statement that a greater benefit can be expected from more physical activity and that the training should be personalized and highly titrated. patients in advanced stages of cvd and very inactive patients, defined as \<14 mets h/week, achieve the greatest health benefit from increased physical activity. despite the well-studied benefits, even adherence to the above minimum recommendations for cvd patients after completion of cr is low. this deficit has been addressed in the latest european prevention guideline and recommended that patients i) set clearly defined goals, ii) exercise in the iii) identify obstacles on the way to achieving the goals so that lifestyle changes are effective and sustainable and the benefits of physical activity can be achieved and maintained. the planned study will investigate the effect of multi-modal support measures to help patients during the home training phase and their influence on the patients' lifestyle.


Eligibility criteria:
inclusion criteria: * age \>= 18 years * participation rehabilitation phase iii new * documented cardiovascular disease * signed informed-consent exclusion criteria: -

Keywords: rehabilitation cardiovascular disease outpatient cardiac rehabilitation
prevalence of lipodystrophy syndrome and its role as cause of metabolic disturbances

Conditions: Lipodystrophy; Metabolic Syndrome

Summary: to evaluate the prevalence of lipodystrophy syndrome in patients receiving currently available antiretroviral drugs, and the prevalence of associated metabolic syndrome in hiv-infected patients with a previous diagnosis of lipodystrophy syndrome, according to the severity of fat accumulation and antiretroviral drug use.

cross-sectional evaluation of two groups of patients: * patients receiving currently available drugs, in order to determine the changes in fat accumulation by successive dual x-ray absorptiometry (dxa) determinations * patients with previous lipodystrophy syndrome, as evaluated by questionnaire (hops) and total body dual x-ray absorptiometry (dxa), in order to determine the prevalence of hypertension, low high density lipoprotein (hdl)-cholesterol, glucose disturbance (insulin resistance or diabetes), fat accumulation (waist circumference) and hypertriglyceridemia. the prevalence of metabolic syndrome will be evaluated according to the different definitions (idf, ncep-atp iii, who).

Eligibility criteria:
inclusion criteria: * hiv infection * older than 18 years * receiving first or second antiretroviral regimen or * previous evaluation and classification of lipodystrophy syndrome exclusion criteria: * pregnancy * diagnosis of hypothyroidism, cushing's syndrome or prolonged intake of corticosteroids or hormones before inclusion * patients who had received antiretroviral drugs known to produce fat disturbances (for lipodystrophy prevalence objective)
global kidney patient trials network

Conditions: Kidney Diseases

Summary: this is a prospective international multi-centre, observational cohort study of incident and prevalent patients diagnosed with a kidney disease


Eligibility criteria:
inclusion criteria: 1. documented diagnosis of primary kidney disease 2. regular visits (at least 6 monthly) with a physician at a participating site 3. egfr \> 15 ml/min/1.73m2 4. ≥ 2 years of age 5. willing and able to sign informed consent 6. willing to be approached about participation in interventional research studies exclusion criteria: 1. life-expectancy of less than 6 months 2. currently receiving renal replacement therapy or planned to start in the next 6 months 3. currently participating in a clinical trial involving investigational medicinal product (exception is participation in studies implemented through the gkptn)

Keywords: chronic kidney disease diabetic nephropathy hypertensive kidney disease glomerulonephritis (gn) focal segmental glomerulosclerosis (fsgs) membranous nephropathy minimal change disease immunoglobulin a nephropathy (igan) glomerulonephritis not otherwise specified gn fsgs
fluid responsiveness in septic shock evaluated by caval ultrasound doppler examination

Conditions: Septic Shock; Vein Collapsibility; Intravascular Doppler; Volume Responsiveness in Septic Shock

Summary: the study aims at clarification of venous collapsibility measures with real venous flow measurements during dynamic maneuver testing fluid responsiveness in septic shock patients.

sedated and mechanically ventilated patients in septic shock will be enrolled in the study. a fine catheter with ultrasound doppler probe will be introduced into the central venous catheter already in place in superior vena cava. doppler signal will be evaluated by console prototype (nilus medical) and continuous analysis of blood flow velocity respiratory variation will be performed. these values will be compared to standard hemodynamic monitoring parameters (central venous and arterial pressures) and to parameters acquired by transoesophageal (toe) and transthoracic echocardiography.

Eligibility criteria:
inclusion criteria: * patients in severe sepsis or septic shock * intubation and mechanical ventilation * sedated patient without spontaneous respiratory efforts * central venous catheter in place inserted via right internal jugular vein * signed informed consent by family members exclusion criteria: * superior vena cava vascular anomaly * irradiation of neck or mediastinum in medical history * thrombosis of superior vena cava in medical history * atrial fibrillation or other irregular rhythm * permanent or external pacemaker * aggressive mechanical ventilation (peep above 10 cm h2o, pmax above 30 cm h2o) * toe contraindication (oesophageal varices, stricture, tumour, upper gastrointestinal bleeding) * pericardial effusion, constrictive pericarditis * moderate or severe valvular lesion * severe systolic dysfunction of the left (ef less than 30%) or right ventricle (fac less than 25%) * intraabdominal pressure above 20 mmhg * open chest * obvious severe hypovolemia ( lveda\<5.5cm2/m2bsa)
testicular vascular evaluation in patients undergoing inguinal hernia repair

Conditions: Inguinal Hernia; Testicular Diseases

Summary: patients scheduled to undergo laparoscopic preperitoneal or open inguinal hernia repair will be evaluated by means of scrotal/testicular ecocolordoppler ultrasound investigation before and after surgery in order to rule out the potential impact of the surgical procedure on testicular arterial and venous blood flow

patients scheduled to undergo laparoscopic preperitoneal or open inguinal hernia repair will be evaluated by means of scrotal/testicular ecocolordoppler ultrasound investigation before and after surgery in order to rule out the potential impact of the surgical procedure on testicular arterial and venous blood flow ecocolordoppler will evaluate: 1. testicular arterial flow (peak systolic velocity testicular artery - end-diastolic velocity testicular artery - resistive index testicular artery) 2. venous impaired outflow using varicocele classifications (dubin - scale 1-3; hirsch scale 1-5) 3. testicular volume

Eligibility criteria:
inclusion criteria: * inguinal hernia with surgical indication for surgical repair exclusion criteria: * history of urologic surgery and/or radiotherapy * recurrence of inguinal hernia