Kornimate/medical-research-clean huggingface dataset:
an open-label, pilot clinical trial to test the safety and feasibility of a suspension of freeze-dried microbiota in patients undergoing colon resection

Conditions: Recurrent Clostridioides Difficile Infection; Colonic Surgery

Summary: this phase 1 pilot clinical trial that will evaluate the initial safety and feasibility of orally administered preparation of fecal microbiota (mtp-101p) in patients undergoing colon resection. we plan to enroll male and female patients, ages 18-75, diagnosed with colon polyps or early (stage i or ii) colorectal cancer or medically refractory diverticulitis. we will recruit 40 patients total to receive the investigational product. this trial will inform development of future trials in treatment of colon and rectal surgery. active drug is composed of highly purified, freeze-dried, fecal microbiota from healthy donors. this study will also allow for limited evaluation of pharmacokinetics in terms of donor microbiota engraftment. the exploratory objective is to evaluate engraftment of donor microbiota with this preparation and compare the results with data generated with the data generally from microbiota transplantation (ind28152).


Eligibility criteria:
inclusion criteria: * able/willing to provide informed consent * between 18-75 years of age * undergoing surgery for unresectable polyps, early-stage colon cancer (stage 1 or 2) not predicted based on pre-operative national comprehensive cancer network guidelines to meet criteria for adjuvant chemotherapy, or a history of diverticulitis. * able to provide fecal samples. * stated willingness to comply with all study procedures and availability for the duration of trial to follow-up by telephone, in-person, email, and/or video visits or correspondence exclusion criteria: * any history of inflammatory bowel disease * pregnancy or breastfeeding. a pregnancy test will be obtained from females of child-bearing potential on the proposed day of mtp-101p (prior to its administration). patients with a positive pregnancy test will be excluded. a negative result will be required for subjects who are females of child-bearing potential to receive mtp-101p. * life expectancy of \< 6 months * presence of ileostomy or colostomy * known history of inflammatory bowel disease (crohn's, ulcerative colitis) * patients on immunosuppressants (calcineurin inhibitors, prednisone ≥ 20 mg/day, methotrexate, azathioprine, immunosuppressive biologics, jak inhibitors). * patients with neutropenia (an absolute neutrophil count \<0.5 x 10\^9 cells/l) obtained on a complete blood count with differential at screening. * history of solid organ or bone marrow transplant. * anticipated recurrent antibiotic use (e.g., patients with frequent urinary tract infections or sinusitis). * history of severe anaphylactic food allergy. * history of celiac disease. * patients receiving cancer chemotherapy, immunotherapy, or radiation.
a novel technique for prediction of preterm birth: fetal breathing patterns

Conditions: Preterm Birth

Summary: preterm birth refers to a delivery that occurs before 37 weeks of gestation. identification of those who will eventually deliver in the preterm period is very important. however, few interventions have been proven to prolong pregnancy in women at risk such as cervicovaginal fetal fibronectin (ffn) level or transvaginal cervical length measurements. in a meta-analysis comparing fetal breathing with cervicovaginal fetal fibronectin (ffn) level or transvaginal cervical length measurements, absence of fetal breathing was superior to other methods for prediction of preterm birth in 48 hours or 7 days. in this study, the investigators hypothesized that if a fetus holds its breath in case of preterm birth, then there may be specific fetal breathing patterns during preterm labor, which may be detected by ultrasonography

preterm birth refers to a delivery that occurs before 37 weeks of gestation and it is the leading cause of neonatal morbidity and mortality. 33% of prenatal hospital admissions are due to preterm labor but almost 50% of patients receiving tocolytics in order to prevent birth deliver in the term period. therefore, identification of those who will eventually deliver in the preterm period is very important. ideally, identification of modifiable and nonmodifiable risk factors for preterm birth in will lead to interventions that help prevent this complication. however, few interventions have been proven to prolong pregnancy in women at risk such as cervicovaginal fetal fibronectin (ffn) level or transvaginal cervical length measurements. another method for preterm birth prediction is presence of fetal breathing. in a meta-analysis comparing fetal breathing with cervicovaginal fetal fibronectin (ffn) level or transvaginal cervical length measurements, absence of fetal breathing was superior to other methods for prediction of preterm birth in 48 hours or 7 days. in this study, the investigators hypothesized that if a fetus holds its breath in case of preterm birth, then there may be specific fetal breathing patterns during preterm labor, which may be detected by ultrasonography

Eligibility criteria:
inclusion criteria: * pregnant patients between 24-37 gestational weeks with preterm labor : uterine contractions ≥4 in number in 20 minutes or ≥ 8 in number in 60 minutes and one of the following: * cervical dilation ≥ 3 cm * transvaginal cervical length \<20mm exclusion criteria: * multifetal pregnancy * cervical dilation \> 5 cm * heavy vaginal bleeding * non-reassuring fetal non-stress test * preterm premature rupture of membranes * intrauterine growth restriction * oligohydramniosis * fetal anomaly * patients who received tocolytics for preterm labor or corticosteroids for lung maturation * drug or substance use which may depress fetal breathing

Keywords: preterm birth fetal nasal doppler fetal breathing
using continuous glucose monitoring to quantify the effects of nourish's culturally modified meals on asian americans with type 2 diabetes

Conditions: Type 2 Diabetes Mellitus (T2DM); Type 2 Diabetes

Summary: the investigators are hoping to determine whether tailoring the diet of someone with type 2 diabetes to their ethnic group while following american diabetes association guidelines can make a significant difference in their blood sugar controls. participants will be required to wear a continuous glucose monitor (cgm) for 1-month so that the investigators can compare blood sugar levels when participants are eating their routine diet vs. the culturally tailored diabetes diet.

this clinical trial evaluates the impact of culturally tailored, american diabetes association (ada)-compliant meals on the glycemic control of asian indian and filipino individuals with type 2 diabetes mellitus (t2dm). this study leverages a crossover design to compare glycemic responses during two distinct dietary phases: a self-selected diet phase (baseline/control/routine diet) and an intervention phase featuring nourish meals. nourish meals will be delivered to designated pick-up points on the stanford campus and stanford clinics. participants will be equipped with continuous glucose monitors (cgms) to track glucose trends across the study and will be required to keep a food log through tastermonial, enabling detailed analysis of postprandial glucose responses and key metrics.

Eligibility criteria:
inclusion criteria: * self-identification as asian indian or filipino * diagnosed with t2dm * can pick up meals from a designated area on the stanford campus * willing to wear a cgm for 30 days exclusion criteria: * currently taking insulin, glp -1 and sglt 2 * known severe allergic reactions and/or food intolerances that would interfere with the ability to eat * those who, in the opinion of the investigators, cannot reliably complete the study protocol.

Keywords: type 2 diabetes asian american asian indian filipino medically tailored meals culture culturally tailored meals continuous glucose monitoring nutritional interventions dietary adherence diabetes management
colonisation of scalp by topical probiotic micrococcus luteus q24

Conditions: Microbial Colonization

Summary: the purpose of this study is to evaluate the skin quality improvement and colonization efficacy following the application of probiotic micrococcus luteus q24 (blis q24) to the scalp from a serum format in healthy adults.

this is a randomized double-blind baseline controlled pilot study with no crossover for the assessment of any changes to the microbial make-up of the skin (the local skin microbiome), detection of colonization by the probiotic bacterium (blis q24) on the skin on the scalp and to evaluate the changes in skin quality parameters following topical application of probiotic in a serum format.

Eligibility criteria:
inclusion criteria: 1. in general, good health, is 18 - 80 years of age. 2. practice good general body and hair hygiene. exclusion criteria: 1. have a history of autoimmune disease or are immunocompromised (have a weakened immune system). 2. free from any scalp disease, active cut, or open wound 3. on hair loss treatment at least 2 months prior to sampling. 4. have used anti-dandruff shampoos on the scalp and hair for at least 1 week prior to the trial. 5. on concurrent antibiotic or antifungal therapy or regular antibiotic or antifungal. use within the last 1 week. 6. people with allergies or sensitivity to dairy.
one-anastomosis gastric bypass/mini-gastric bypass versus roux-en y gastric bypass

Conditions: Obesity

Summary: the aim of this prospective randomized controlled trial is to compare the two procedures one-anastomosis gastric bypass/mini-gastric bypass (oagb/mgb) and roux-en y gastric bypass (rygb) in relation to intraoperative and postoperative complications (classification of clavien-dindo), mortality, metabolic impact (remission of type 2 diabetes mellitus, hypertonus, gastro-esophageal reflux disease, sleep apnea, dyslipidemia, quality of life, operation time, postoperative excess weight loss, malnutrition and re-do/revisonal surgery.

oagb/mgb is gaining popularity as a primary surgical treatment for morbid obesity due to reduced operation time, a shorter learning curve, better weight loss, higher metabolic impact and fewer major complications compared to rygb. in this prospective randomized controlled trial we want to compare oagb/mgb and rygb with a fu of up to 24 month. patients with indication for gastric bypass get randomized in group a (rygb, n = 50) or b (oagb/mgb, n = 50). fu is performed 1, 3, 6, 12 and 24 month after surgery.

Eligibility criteria:
inclusion criteria: 1. primary obesity surgery and indication for gastric bypass 2. age: 18 - 65 years 3. bmi \> 40 kg/m² or bmi \> 35 kg/m² with obesity related comorbidities 4. informed consent exclusion criteria: 1. obesity surgery in the anamnesis 2. visceral surgery in the anamnesis (excluding appendectomy and cholecystectomy)

Keywords: roux-en y gastric bypass one-anastomosis gastric bypass mini-gastric bypass metabolic surgery
pilocarpine after combined cataract/trabectome surgery

Conditions: Open Angle Glaucoma; Ocular Hypertension

Summary: combined cataract + trabectome surgery is a surgery designed to help lower the intraocular pressure (pressure in the eye) and hopefully reduce the need for topical drops, progression of glaucoma, and/or further glaucoma surgeries. the purpose of this study is to assess whether using pilocarpine, a medication which is fda approved to induce miosis, (in other words cause the pupil to constrict or become smaller) provides additional benefit to the success of trabectome and cataract surgery.

glaucoma is the leading cause of irreversible blindness worldwide, and its treatment consists of lowering intraocular pressure (iop) to prevent damage to the optic nerve and loss of vision. microincisional glaucoma surgery (migs) have become more popular in recent years as less invasive methods than traditional surgeries that effectively reduce iop and help reduce the medication burden on patients.there are multiple available migs procedures, most of which act by increasing trabecular outflow. one such procedure is the trabectome, which is usually performed in combination with cataract surgery. trabectome is an fda approved device used to perform a trabeculectomy via an internal approach. a strip of 60-120 degrees of the nasal angle trabecular meshwork and the inner wall of schlemm's canal are removed providing a direct pathway for aqueous outflow from the anterior chamber into the collector channels\[2\]. pilocarpine, a parasympathomimetic agent, is a glaucoma medication that works by causing contraction of the ciliary muscle leading to opening of the trabecular meshwork\[3\]. due to its frequent dosing requirement and large number of ocular and systemic side effects, pilocarpine has largely fallen out of favor for the treatment of primary open angle glaucoma (poag), except in patients for whom few other alternatives exist. however, pilocarpine is often used after trabectome surgery. the rationale for its use after trabectome procedure is for its miotic effect, which theoretically may prevent the formation of peripheral anterior synechiae. formation of peripheral anterior synechiae can lead to the closure of the cleft that is generated and the possibility of failure of the procedure. while the theoretical benefit of pilocarpine has been proposed, its actual benefit has never been proven. in this study, the aim is to evaluate whether trabecome / cataract surgery without pilocarpine is non-inferior to trabecome / cataract surgery procedure followed by treatment with pilocarpine

Eligibility criteria:
inclusion criteria: * age range: 30 to 100 years old * patients with ocular hypertension or open angle glaucoma undergoing combined cataract surgery with trabectome in a single surgical center exclusion criteria: * patients with previous history of eye surgeries (including laser procedures).

Keywords: cataract surgery trabectome eye surgery vision glaucoma surgery
the effect of parental anxiety level on the child's anxiety level and postoperative pain in children undergoing surgery.

Conditions: Anxiety; Children

Summary: the aim of this prospective study is to investigate whether the anxiety levels of parents of children aged 2-6 years who will undergo inguinal area surgery have an effect on the child\&#39;s preoperative anxiety level and postoperative pain level.

hospitalization of children for any health problem or treatment is a complex and difficult process that negatively affects the child and his family and creates stress. surgical treatment in children can be planned or unplanned, minor or major, invasive or non-invasive, but every type of surgery is considered a stressful experience. studies have shown that by controlling the anxiety and fear experienced in the preoperative period, children can achieve faster recovery in the postoperative period, better pain tolerance and earlier discharge. for this reason, we aim to contribute to the literature by investigating whether the anxiety levels of the parents of children aged 2-6 who will undergo inguinal area surgery affect the child\&#39;s preoperative anxiety level and postoperative pain level.

Eligibility criteria:
inclusion criteria: * the child is between the ages of 2-6 * patients scheduled for surgery under general anesthesia due to inguinal area pathology * surgery performed as planned * there is no mental or neurological disorder in both the mother and the child. * there are no vision, hearing or speech problems in both the mother and the child. * parents and children who volunteer to participate in the research * children with asa i exclusion criteria: * not volunteering to participate in the study (those for whom parental consent cannot be obtained) * those who underwent surgery with a pathology other than the inguinal area * having emergency surgery * children at risk with asa 2 and above * having a pathology that may cause difficulty in communicating with both the family and the child (such as mental retardation, neurological problem).

Keywords: children anxiety analgesia pediatric anaesthesia
radiomics in pancreatic cancer

Conditions: Pancreatic Cancer

Summary: the images of patients with pancreatic cancer were collected and analyzed based on the methodes of radiomics


Eligibility criteria:
inclusion criteria: * gender unlimited, 18-80 years old; * received abdominal imaging; * informed consent signed. exclusion criteria: * pregnant / lactating women； * contraindications of imaging examination。
assessment of the sympathetic nervous system blockade of the upper limb after a brachial plexus block in patients with end stage renal failure

Conditions: Renal Failure

Summary: the purpose of this study is to investigate what effect a local anesthetic nerve block of the arm in patients with end stage renal failure has upon blood flow in the skin of the arm.

aim to quantify the degree of sympathetic blockade in the upper limb in patients with end stage renal failure produced during a regional anaesthetic technique, using laser doppler flowmetry. hypothesis regional anaesthesia of the upper limb results in blockade of motor and sensory nerves, providing surgical and post-operative analgesia. sympathetic nerves are also blocked resulting in local vasodilatation. this may be of benefit in surgery where enhanced blood flow is beneficial such as arterio-venous fistula creation. the degree and duration of sympathetic blockade produced by regional blocks however, has never been quantified. this study aims to quantify sympathetic blockade by measuring the changes in skin blood flow and skin temperature after placement of a brachial plexus block.

Eligibility criteria:
inclusion criteria: * patients with end stage renal failure * over 18 years of age * written consent obtained * due to undergo surgery for forearm fistula creation under a regional block exclusion criteria: * smokers * damaged skin on the arm * circulatory disorders such as raynaud's disease, systemic sclerosis, sickle cell trait or disease * current use of beta blockers * undergoing haemodialysis for more than 12 months
yoga to prevent mobility limitations in older adults

Conditions: Aging; Mobility Limitation; Sedentary Lifestyle

Summary: the loss of mobility during aging impacts independence and leads to further disability, morbidity, and reduced life expectancy. the study objective was to examine the feasibility and safety of conducting a randomized controlled trial of yoga for older adults at risk for mobility limitations. the investigators hypothesized that sedentary older adults could be recruited for the study, would attend either yoga or a health education control, would complete assessments, and that the interventions could be safely delivered.


Eligibility criteria:
inclusion criteria: * age 60-89 years * self-reported sedentary lifestyle (not exercising in the past 3 months; included walking at a brisk pace or regular walking for exercise purposes) * sppb summary score \> 3 and ≤ 8 * willingness attend either yoga or health education for 10 weeks * willing to complete two assessments * residence in san diego metropolitan area * provided a physician-signed health clearance form. exclusion criteria: * practiced yoga \> 2x in the last year * life expectancy \< 12 months.
notification of incidental coronary artery calcium in patients with atherosclerotic cardiovascular disease (notify-ascvd)

Conditions: ASCVD; Coronary Artery Calcification

Summary: estimate the impact of notifying both patients and their clinicians of the presence of incidental coronary artery calcium (cac) on initiation of lipid-lowering therapy in patients with ascvd who are not receiving lipid-lowering therapy.

this is a randomized quality improvement (qi) project evaluating the impact of notifying patients and their clinicians (primary care, cardiologists, neurologists, or vascular surgeon) of incidental cac detected on a prior chest ct scan. patients will be identified by screening previous non-gated chest ct scans and electronic health records. the presence of cac will be confirmed by a radiologist. eligible patients will be randomized to: 1) notification of presence of cac with a ct scan image; 2) notification of presence of cac without a ct scan image; 3) or usual care.

Eligibility criteria:
inclusion criteria: 1. presence of cac on non-gated chest ct scans performed from 2021 to 2023 2. age \<85 years 3. diagnosis of coronary artery disease, peripheral artery disease, or cerebrovascular disease 4. visit to stanford affiliated clinician since 2021 at one of the following stanford clinics including university affiliated clinics: 1. internal medicine 2. family medicine 3. cardiology 4. neurology 5. vascular surgery exclusion criteria: 1. no diagnosis of ascvd 2. patients receiving lipid-lowering therapy 3. dementia 4. metastatic cancer or active cancer undergoing chemotherapy
thyroid and cortisol hormone response to sepsis

Conditions: Sepsis

Summary: thyroid and cortisol hormone response to sepsis

sepsis is dysregulated host response to infection that results in life-threatening organ dysfunction. virtually every body system can be affected by this syndrome to greater or lesser extents. endocrine alterations are well characterised in sepsis with variations in circulating blood levels and/or receptor resistance. in response to any psychological or physical stressor, there is widespread neurohormonal activation to adapt body with the stressor. production and secretion of stress hormones increase to modulate behaviour many studies have been performed investigating specific hormonal perturbations such as critical illness-induced corticosteroid insufficiency ,all of which are associated with worse outcomes and poor of body inflammation. however, the endocrine system as a whole has been largely overlooked as a fundamental contributor to the integrated host response to sepsis thyroid axis is affected during sepsis with decreased pituitary release of thyroid stimulating hormone (tsh) and inhibition of the peripheral conversion of thyroxine (t4) by 5-deiodinase to the much more metabolically active triiodothyronine (t3). high cortisol levels also inhibit this enzymatic conversion.

Eligibility criteria:
inclusion criteria: * the study will include adults (≥18 years), both genders * septic patients admitted to critical care unit exclusion criteria: * thyroid disease * hypopituitarism * addison disease * cushing syndrome)