Kornimate/medical-research-clean huggingface dataset:
long term outcome of argon plasma coagulation of cervical heterotopic gastric mucosa as an alternative treatment for globus sensations

Conditions: Globus Sensations in the Throat

Summary: apc of gastric inlet patches is successful for the treatment of globus sensations in the throat (bajbouj et al gastroenterology 2009; 137:440-4). there is no data for long term efficiency of this treatment. to measure long term efficacy all patients treated with this therapy in our clinic were followed up with complaint-evaluation sheets and endoscopy.


Eligibility criteria:
inclusion criteria: * former apc therapy of gastric inlet patches as treatment for globus sensations * at least 6 month since last apc therapy exclusion criteria: * patients with reduced general condition * malignancy of the upper gastrointestinal tract * patients older than 80 years

Keywords: gastric inlet patches argon plasma coagulation globus sensations
afp- l3% and dcp as tumor markers in patients with hepatocellular carcinoma (hcc) treated with transarterial chemoembolisation (tace)

Conditions: Hepatocellular Carcinoma

Summary: hepatocellular carcinoma (hcc) is one of the tumors with an increasing incidence worldwide. often treatment possibilities are limited and only palliative treatment such as a transarterial chemoembolisation (tace) is possible. therapeutic response is evaluated three months after tace by imaging techniques (ct, mri). in some hcc patients the tumor marker afp ( alpha-fetoprotein) is elevated, but not all patients show this elevation. in the last years new tumor markers such as afp-l3 (subfraction of afp) and des-y-carboxyprothrombin (dcp) have been examined. in this clinical trial the course of these markers are examined after tace in order to receive hints if the patient will be a therapeutic responder. furthermore the investigators are interested in the quality of life after tace. patients receive a questionnaire with regard to the quality of life before and 3 months after tace.

patients with hepatocellular carcinoma (hcc) treated with transarterial chemoembolisation are enrolled in this clinical trial. the aim of this trial is to evaluate the usefulness of the liver cancer markers afp, afp-l3% (subfraction of afp) and des-y- carboxyprothrombin (dcp) after tace therapy. some authors could have shown that afp-l3% is rising in small tumor nodules under 2 cm and so the markers which should decrease after tace can give a hint for the therapeutic response after the intervention. so the important aim of this trial is to improve the early detection of tumor recurrence after tace. furthermore the quality of life measured by the eortc qlq c30 before and after tace is evaluated.

Eligibility criteria:
inclusion criteria: * age between 18 and 80 * diagnosis of hcc according the aasld criteria * tace is planned * resection is impossible exclusion criteria: * liver tumor of unknown origin * other liver tumors * tace is impossible

Keywords: hepatocellular carcinoma transarterial chemoembolisation liver cancer markers: afp, afp-l3% and dcp
effects of video information on preoperative anxiety in patients with colorectal cancer

Conditions: Colorectal Cancer; Video Information

Summary: patient's anxiety prior to surgery has been linked to more harmful outcome after surgery. the investigators aim to evaluate the effect of video information on preoperative anxiety level in patients with colorectal cancer.


Eligibility criteria:
inclusion criteria: * age: 20-75 * elective surgery exclusion criteria: * history of previous any surgery * emergency surgery * dementia * psychological disease
neochord tact post-market surveillance registry

Conditions: Mitral Valve Insufficiency; Heart Valve Diseases; Heart Diseases; Cardiovascular Diseases

Summary: to monitor the long-term performance of the ce marked neochord artificial chordae delivery system


Eligibility criteria:
inclusion criteria: * grade 3+ or 4+ mitral valve regurgitation exclusion criteria: * heavily calcified valves * valvular retraction with severely reduced mobility * active bacterial endocarditis * complex mechanism of mr (leaflet perforation, etc.) * significant tethering of leaflets * inflammatory valve disease

Keywords: neochord ds1000 mitral valve mitral valve regurgitation mr mitral valve repair mitral valve prolapse artificial chordae
esophageal absorption in eoe

Conditions: Eosinophilic Esophagitis

Summary: to determine how the esophagus in active and inactive stages of eosinophilic esophagitis tranmit fluids.


Eligibility criteria:
inclusion criteria: * patients between the ages of 18 and 80 with eosinophilic esophagitis diagnosed by a combination of compatible symptoms, endoscopic findings, histology, and lack of response to proton pump inhibitors or negative ph study * endoscopy with esophageal and duodenal biopsies within two weeks of performance of this study * patients between the ages of 18 and 80 with eosinophilic esophagitis diagnosed by a combination of compatible symptoms, endoscopic findings, histology, and lack of response to proton pump inhibitors or negative ph study, and are now in histologic remission( \<15phf) by the use of steroids or the six food elimination diet. * volunteers will be selected for not having any history of esophageal symptoms exclusion criteria: * vulnerable populations, such as those with diminished mental acuity, will be excluded. * patients taking nsaids within 48 hours of the d-xylose testing * artificial sweeteners within 48 hours of the d-xylose testing * history of ibd * currently smoking or history of smoking * history of celiac disease * bacterial overgrowth, * motility disorders * other diffuse small bowel diseases.

Keywords: eosinophilic esophagitis eoe dysphagia
eus guided liver biopsy - will it give better yield, more tissue with less complication?

Conditions: NAFLD; Alcoholic Hepatitis

Summary: liver biopsy would be done by endoscopic ultrasound using acquire needle.

in this study, we aim to evaluate the tissue adequacy of eus guided liver biopsy for parenchymal liver disease and to evaluate if diagnostic yield of left lobe is non-inferior to right lobe biopsies and to assess if combination biopsies have better yield than single lobe biopsies. safety of the procedure and technical success would be noted. the data would be analysed using spss software and needful variables and tests would be used as per statistical requirement.

Eligibility criteria:
inclusion criteria: * patients of any undiagnosed hepatic disease (after extensive investigation - serological as well as imaging) requiring a liver biopsy * patients of nafld who need liver biopsy * alcoholic hepatitis patients needing biopsy * any patient with unexplained transaminesemia \> 1.5 times uln needing a liver biopsy as advised by hepatologist exclusion criteria: * any liver space occupying lesion suspicious of malignancy * platelet count \<80,000 * inr \> 1.5 * pregnancy * severe cardiovascular and pulmonary diseases * recent use of anti-platelet agents within 5 days of the procedure * unwilling to provide informed consent
effects of inspiratory muscle and endurance training in heart failure patients with pacemaker

Conditions: Pacemaker

Summary: it is well-known that not only peripheral muscles, but also respiratory muscles muscle weakness and deconditioning play an important role in low exercise capacity of patients with heart failure (hf). exercise training has been shown to improve exercise tolerance and quality of life in patients with heart disease. however, hearth failure patients with pacemaker such as implantable cardioverter defibrillators (icds), cardiac resynchronization pacemakers or defibrillators (crt-p or crt-d) have additional specific issues when performing exercise. no study investigated the effects of different inspiratory muscle training protocols. for this reason, we aimed to investigate the effects of inspiratory muscle training on outcomes in hearth failure patients with pacemaker

heart failure patients with pacemaker will be included. primary outcome measurement is respiratory muscle strength, secondary outcomes are functional exercise capacity, peripheral muscle strength, pulmonary functions, maximal exercise capacity, fatigue, quality of life, depression, physical activity.

Eligibility criteria:
inclusion criteria: * heart failure patients with pacemaker who are clinically stable * after 12 weeks of pacemaker implantation * no change in medications over one month exclusion criteria: patients with * severe cognitive disorders * pulmonary, neurological and orthopedic diseases * pregnant and lactating patients * acute infection or exacerbation

Keywords: pacemaker inspiratory muscle training exercise capacity quality of life respiratory muscle strength
children and adolescents with dental anxiety - randomized controlled study of cognitive behavioral therapy

Conditions: Dental Anxiety

Summary: the purpose of this study is to determine whether cognitive behaviour therapy is effective in the treatment of children and adolescents with dental anxiety. our hypothesis is that children and adolescents who have been offered cbt shows significant better performance on outcome measures compared with patients in control group who have received treatment as usual.


Eligibility criteria:
inclusion criteria: * the patient and parents agree to participate in the research project * a primary diagnosis of specific phobia (dental anxiety or needle phobia) can be established according to the diagnostic and statistical manual of mental disorders, 4th. edition. exclusion criteria: * the diagnostic interview shows that other psychiatric or developmentally related diagnoses should be consider as the primary diagnosis * the patient undergoing psychiatric examination and/or psychotherapy * the patient has no dental treatment needs or the dental treatment needs are of an emergency nature.

Keywords: dental fear dental phobia cognitive behavior therapy specific phobia children and adolescents anxiety self efficacy
lamellar transplant with lyophilized corneas

Conditions: Keratoconus

Summary: - the goals of this study are to develop a lyophilization method for anterior lamellar transplants in brasil and to make a comparative analysis among patients transplanted with lyophilized and optisol corneas

* after the development of a techinique to lyophilize corneas, we randomly assingned 20 patients with keratoconus and visual acuity of \< 20/60, who signed the consent term and divided them into 2 groups. one group was transplanted with lyophilized corneas and the other group with optisol corneas. * patients are being followed for 6 months with visual acuity, refraction, topography, orbscan, pachmetry, ultrasound biomicroscopy and confocal microscopy. * results are going to be statistically analysed by spss program.

Eligibility criteria:
inclusion criteria: * keratoconus patient * bcva \< 20/60 * no systemic diseases * who signed the inform consent exclusion criteria: * bcva \> 20/60 * presence of deep opacities * systemic diseases

Keywords: lamellar transplant lyophilization corneas storage keratoconus patients best corrected visual acuity < 20/60 signed the consent inform
precision imaging to evaluate kaposi sarcoma (prime-ks): a device feasibility trial

Conditions: Kaposi Sarcoma

Summary: while tremendous progress has been made against hiv, both in preventing the infection and in treating aids, the disease it causes, aids-related malignancies like kaposi sarcoma (ks) remain a significant health burden, in both the u.s. and especially the developing world. in many cases, multiple ks lesions develop simultaneously, and may progress and regress independently. photographs are an essential part of the evaluation for ks, as reflected in their formal usage described in the ks tumor assessment manual of procedures. however, acquiring a clear, informative photo is not trivial, since anatomy is 3d and conventional imaging is 2d. the importance of accurate, quantitative 3d information is especially pronounced for the treatment of ks because when a tumor responds positively to treatment, the initial change is usually a flattening of the lesion, without any significant change in the projected 2d area. to evaluate the vertical space, along with other characteristics of a ks lesion, we have created an innovative imaging system, skinscan3d, utilizing new commercial liquid lens technologies and ai based image analysis software, with strategies borrowed from astronomical imaging techniques previously used on nasa space telescopes. in this study, the investigators will develop and demonstrate a protocol for recording measurable 3d parameters, which may be used in a longitudinal study to rigorously monitor therapeutic responses of ks and statistically compare with that of the conventional amc criteria.


Eligibility criteria:
eligibility criteria: * have been diagnosed with histologically or cytologically proven kaposi sarcoma (ks). * has at least 3 cutaneous kaposi sarcoma lesions. * at least 18 years of age. * ability to understand and willingness to sign an irb approved written informed consent document.

Keywords: kaposi imaging photography 3d
a comparative study of support devices for ventilator-assisted icu patients

Conditions: Device Dislocation

Summary: assisting critically ill patients with early mobilization or early ambulation during their stay in the intensive care unit (icu) can reduce the duration of mechanical ventilation use, length of icu or hospital stay, probability of complications during hospitalization, and sedation days in the icu and improve disease prognosis. however, over 80% of critically ill patients have endotracheal tubes and require the use of mechanical ventilators in the icu, and due to the numerous invasive treatments and tubes, there are high concerns regarding the safety of tube stability and risk of tube dislodgement during early mobilization. although there are commercially available fixed tracheal tubes or external support devices for breathing tubes to prevent displacement, they do not solve the problems of the weight of the breathing tube during ambulation or endotracheal tube slippage. therefore, through interdisciplinary collaboration, the investigator has designed a "wearable support device" (type a support device). the unique design of the fixed frame uses a plug-in-latch shape to fix the y-shaped breathing tube to the patient's chest position. in addition to reducing the displacement of the free section of the endotracheal tube downwards, it can also fix the main body of the breathing tube. the dual-disc strap method allows adjustment of the position and tightness for patients of different body sizes, and a single specification can be used for patients of various body shapes. currently, a modified version of this wearable support device (type b support device) has been designed based on clinical suggestions.the purpose of this study is to compare the feasibility, safety, and comfort of using the type a-support device and the type b-support device to assist in supporting breathing tubes during early ambulation in icu patients using mechanical ventilators.


Eligibility criteria:
inclusion criteria: 1. glasgow coma scale score of ≥6, 2. relatively stable respiratory status (oxygen saturation \>92%, settings on the mechanical ventilator: fraction of inspired oxygen ≤60%, positive end-expiratory pressure ≤10 cmh2o) 3. a stable cardiovascular system (resting heart rate ≤130 and \>40 beats per minute) 4. no requirement for high-dose vasopressors \>0.2 μg/kg/min). exclusion criteria: 1. patients with temporary limb immobilization as prescribed by the physician. 2. patients with a tendency to bleed. 3. patients with pre-existing mental abnormalities. 4. patients who are expected to die within the next 24 hours or are primarily receiving palliative care in the intensive care unit. 5. patients with sustained intracranial pressure elevation (\> 20 millimeters of mercury (mmhg)). 6. pregnant patients. 7. uncontrolled epilepsy. 8. acute myocardial infarction or rapidly progressing neuromuscular diseases occurring in the intensive care unit. 9. patients with abnormal skin conditions such as skin abrasions, redness, swelling, etc., in the chest/back area.

Keywords: intensive unit care early mobilization mechanical ventilation
hemodynamic changes in the aorta after endovascular treatment of the aortic dissection

Conditions: Aortic Dissection

Summary: aortic dissection (ad) is a serious pathology affecting one person for 300 000 habitants per year. in case of complicated ad on the descending aorta, it is necessary to perform an endovascular surgery in association with medical treatment. an endoprosthesis is implanted on the descending thoracic aorta in order to close the main intimal tear. this closure lead to an increase in the thoracic true lumen diameter, a decrease in the thoracic false lumen diameter, a better perfusion of the aortic branches. furthermore, even in case of open surgical treatment of the ascending aorta it can be necessary to perform an endovascular treatment on the descending aorta, either to prevent and treat aneurysmal evolution or to treat patent malperfusion syndrome. ct and magnetic resonance angiography, by the realization of an aortic morphologic evaluation, are the two key imaging exams in the da. nevertheless, ct can't provide aortic dynamic evaluation, contrary to mri. this exam, thanks to the phase-contrast sequence can measure velocity and flow data in vessels, including aorta but also true and false lumen in the ad. thus, by verifying the perfusion of the aortic true lumen and the aortic branches it is possible to perform an early evaluation of the endovascular treatment of the da. actually, only one study has realized an aortic dynamic evaluation on the ad, unfortunately this study was limited to non-operated patients. in order to assess the place of mri in the ad, the ingestigation propose to determine if phase-contrast mri is able to evaluate the impact of the endovascular treatment on the hemodynamic state of the aorta and its branches.


Eligibility criteria:
inclusion criteria: * patients with an aortic dissection requiring endovascular treatment * the endovascular treatment will be indicated according to the guidelines after medical, radiological and surgical multidisciplinary discussion in our hospital. * patients that have signed the informed consent form. * members of a social protection scheme. exclusion criteria: * patients with an aortic dissection requiring an emergency intervention * patients with a contra-indication to endovascular treatment * contra-indication to mri: claustrophobia, ferromagnetic materials: pacemaker, prosthetic heart valve, implantable cardioverter defibrillators, vascular clip * pregnancy * breastfeeding * dementia * patients under guardianship * patients with difficulty in understanding the french language

Keywords: aortic dissection hemodynamic 4d flow phase contrast mri
registry study on primary ciliary dyskinesia in chinese children

Conditions: Primary Ciliary Dyskinesia

Summary: this study is a multicenter, prospective cohort study of patients diagnosed with primary ciliary dyskinesia, the clinical information of recruited patients, including clinical manifestations, lung function, chest imaging, quality of life and other indicators, will be followed for 10 years.

all new cases of primary ciliary dyskinesia which was confirmed or diagnosed at each center from the beginning of the study are made the investigation of the clinical manifestations and specific tests by the standard diagnostic process.then all the patients' following clinical data will be followed for 10 years (once per six month): clinical manifestations, lung function, chest imaging (once per year), quality of life and other indicators.

Eligibility criteria:
inclusion criteria: a included patient must be coincident with all the following items: * age 0\~18 years old * any organ system symptoms consistent with pcd and being conform to the clinical diagnostic standard of katergener syndrome or being coincident with at least two following specific tests: * abnormal ciliary beat frequency or movement by the high speed photography microscope * abnormal ciliary structure through the electronic microscopy * the nasal no decreased significantly * the target gene mutation found * the clinical diagnostic criteria of the katergener syndrome: ① bronchial expansion; ② sinusitis or nasal polyps; ③ transposition of viscera and (or) dextrocardia. * if all the typical clinical manifestations but only 1 specific test with positive results, can also be included in the registration of suspected pcd cases * consent to provide the related clinical specimen to the certain hospital * the guardians of the patients fully understand the purpose of the study, volunteer their children to participate in this study, and sign informed consent. exclusion criteria: subject will be excluded if she or he has one of the following: * it is unable to provide complete medical records or the current condition can not accept the diagnosis process * she or he cannot agree to participate in the study.

Keywords: children
the efficacy of methylprednisolone in the treatment of patients with ocular involvement in behcet's disease

Conditions: Behcet's Disease

Summary: the goal of this study is to examine the efficacy of 1gram/day intravenous pulses of methylprednisolone on 3 consecutive days in behcet's patients with ocular involvement. a total of 34 behcet's patients referring to behcet's clinic in shariati hospital whose problem was confirmed with new international criteria of behcet's disease (icbd) will be randomly assigned into one of the two equal groups of intervention or control. behcet's patients are those with ocular involvement who were under the same cytotoxic treatment with cyclophosphamide and azathioprine. for the patients in the intervention group, intravenous infusion of 1000 mg methylprednisolone in 100cc d/w 5% or 100cc d/w5% on 3 consecutive days will be added to treatment diet. then treatment will begin with oral prednisolone, 0.5 mg/kg. after that, all the patients were followed up with no other therapeutic intervention by study group. the patients will be visited every 2 months by an ophthalmologist and study group for 6 months in 3 settings. to estimate the ocular inflammation of patients, we use visual acuity, retinal and ocular posterior chamber inflammation index.


Eligibility criteria:
inclusion criteria: * diagnosed behcet's disease according to international criteria * new or relapse of retinal vasculitis who received any cytotoxic or glucocorticoid since 2 months ago * new or relapse of severe posterior uveitis who are candidate for cyclophosphamide and azathioprine according to their physician exclusion criteria: * not signing the informed consent * visual acuity lower than 1/10 by snellen chart * presence of infectious diseases such as tb * presence of diabetes mellitus, hypertension, heart disease, liver disease, renal disease, or edema * presence of other glucocorticoid consumption contraindications

Keywords: retinal vasculitis posterior uveitis methylprednisolone