Kornimate/medical-research-clean huggingface dataset:
a pilot study of tms effects on pain and depression in patients with fibromyalgia

Conditions: Major Depression; Fibromyalgia

Summary: in this pilot study, the pi proposes to include 20 african american participants with fibromyalgia to explore the effect of r tms on pain and depressive symptoms.

in this pilot study, the pi proposes to include 20 african american participants with fibromyalgia to explore the effect of r tms on pain and depressive symptoms. the focus on african americans is due to the mandate from the funding source (internal), as well as possible higher prevalence of fm in aa women. if recruitment is slow, the pi proposes to open up the study to other groups. twenty subjects will be randomized to either sham or active tms condition. inclusion/exclusion criteria are well thought out and seem appropriate. mtreatments will be administered at iop 5 times/wk with each session lasting 20 minutes. pain intensity and unpleasantness will be measured pre and post each tms session using three different pain evaluation paradigms. gcrc resource is mainly requested for two blood draws pre and post first tms session. the blood samples will be used to measure inflammatory cytokines il-1, il-6, and il-8. the main aim is to ascertain feasibility of the study and secondary aim is to gather information on variability in response for power analysis for future larger study. the introduction and rationale (including pain evaluation, and methods relating to tms) are clearly presented. use of gcrc resources seem appropriate.

Eligibility criteria:
inclusion criteria: * age 18-80, * meet acr criteria for fm for more than 6 months, * may or may not have a diagnosis of major depressive disorder (not bipolar) past or present, * current major depressive episode must be without psychotic features * not be on medication known to increase risk of tms-induced seizures * no prescription medication changes in the previous 4 weeks with agreement not to change during the treatment course (2 weeks) and 2 weeks thereafter * no history of epilepsy or stroke or recent head trauma (loc \> 5 minutes) within the past 6 months * african americans will be initially sought out for study, however the recruitment may extend to include caucasian and hispanic subjects to carry out the study. exclusion criteria: * primary, current diagnosis of schizophrenia * other (non-mood disorder) psychosis * mental retardation * substance dependence or abuse within the past 6 months (except nicotine) * psychotic features in this episode, dementia, or delirium * contraindication to rtms * increased intracranial pressure * brain surgery, or head trauma with loss of consciousness for \> 15 minutes * implanted electronic device * metal in the head, or pregnant * has an active autoimmune, endocrine, viral, or vascular disorder affecting the brain or unstable cardiac disease * uncontrolled hypertension, or severe renal or liver insufficiency * unstable and active suicidal intent or plan * history of attempt requiring medical hospitalization within in the past 6 months * -currently an involuntary inpatient on a psychiatric ward.

Keywords: major depression fibromyalgia tms
transdermal lidocaine for pain control during diagnostic office hysteroscopy

Conditions: Infertility, Female

Summary: to compare the effectiveness of transdermal lidocaine for pain control during diagnostic office hysteroscopy

hysteroscopy is commonly used in the diagnosis and treatment of intrauterine lesions such as polyps, ﬁbroids, septa, and adhesions, and in the presence of abnormal bleeding and during the removal of an intrauterine device or foreign body. cervical ripening is made possible by the use of medication through different routes.

Eligibility criteria:
inclusion criteria: * patients with an indication for ofﬁce hysteroscopy exclusion criteria: * patient refuse to participant * contraindication for lidocaine patch
lidocaine supplement for minimal invasive parathyroid surgery

Conditions: Parathyroid Disease

Summary: primary objective: 1. to determine if the application of lidocaine to the airway will obtund or abolish the laryngeal reflexes. this in turn will lead to a quiescent controlled surgical field.

lidocaine is a local anesthetic that causes numbness to the throat when misted into the air. this numbness in the throat should stop the urge to clear the throat in the middle of the operation. therefore, this should stop the interruptions during the surgery. if you agree to take part in this study, you will be randomly assigned (as in the toss of a coin) to one of 2 groups. participants in group 1 will receive the saline mist. this will moisturize and soothe the throat. participants in group 2 will receive the lidocaine mist. lidocaine or saline is misted into the air that you breathe during the surgery. you and your surgeon will not be told which group you were assigned to. at the end of the surgery, your surgeon will answer some questions to help determine if the use of lidocaine or saline is beneficial. you will be considered off-study once you are sent to the recovery room after surgery. this is an investigational study. lidocaine is fda-approved and commercially available for local anesthesia. if you are in the lidocaine or the saline group. up to 105 patients will take part in this study. all will be enrolled at m. d. anderson.

Eligibility criteria:
inclusion criteria: * all outpatients scheduled for mips at the acb by dr n perrier, dr d evans and dr je lee. exclusion criteria: * patients who are excluded will be any who require elective endotracheal intubation as a preoperative decision by the anesthesia team. these patients will be those with sleep apnea, bmi\>35, uncontrolled gastro esophageal reflux. * patients who have a history of allergy/hypersensitivity to lidocaine.

Keywords: parathyroid disease minimal invasive parathyroid surgery mips laryngeal reflexes lidocaine saline
dance study for post-surgical pain in breast cancer survivors

Conditions: Breast Cancer; Survivorship; Pain, Postoperative

Summary: the purpose of this study is to examine how a 12-week, virtual dance program may improve pain and quality of life in participants with persistent post-surgical pain, or ppsp, following mastectomy or lumpectomy.

this is a single-arm, phase 1 study is to assess how a 12-week, virtual dance program may improve persistent post-surgical pain (ppsp) and other participant-reported outcomes of quality of life, fatigue, and body image for breast cancer survivors following mastectomy or lumpectomy. the study procedures including screening for eligibility and surveys. participation in this research study is expected to last up to 16 weeks. it is expected that about 30 people will take part in this research study.

Eligibility criteria:
inclusion criteria: * history of stage 0-iii invasive breast cancer * having undergone lumpectomy or mastectomy * moderate to severe persistent post-surgical pain, as defined by pain scores ≥3 on a numerical rating scale (nrs) of 0-10 (10 being the most severe pain) at least 3 months after completion of surgery, chemotherapy, and/or radiation * pain scores of 3-4 are categorized as moderate pain; scores of 5-10 are categorized as severe pain26 * age ≥ 18 years * able to read and understand english (to complete required questionnaires and participate in classes) * ability to provide informed consent * ability to perform seated exercises exclusion criteria: * unstable cardiovascular disease in the last 6 months * psychiatric disorders or conditions that would preclude participation in the study intervention (e.g. untreated major depression or psychosis, untreated substance use disorder, severe personality disorder) * metastatic breast or other concurrent cancer * pregnant * recent history of attending regular dance or similar classes (e.g. yoga or tai chi classes i.e. 20 or more classes in the past 6 months) * planned surgery anticipated during the intervention period * history of a chronic medical condition that has the potential to significantly impact upper extremity function (e.g. stroke, parkinson's disease, multiple sclerosis) * currently enrolled in a physical therapy course * presence of medical conditions or medications that would prohibit participation in an exercise program

Keywords: breast cancer survivorship breast cancer survivor survivorship pain, postoperative ppsp persistent post-surgical pain
pet-ct scans in healthy volunteers after flu vaccination

Conditions: Flu

Summary: this study is being done to learn how previous flu vaccination or previous infection with flu virus affects the immune response to vaccination.

until recently, all recipients of influenza vaccine received a killed form of virus, typically in the same nondominant arm, each year before flu season. we hypothesize that natural infection, and some forms of vaccination, could allow vaccine induced responses to spread beyond the local lymph nodes near the vaccination site. from a practical perspective, if vaccine induced proliferation of specific immune cells in sites distant from the vaccination site lead to beneficial immune memory, it would suggest vaccination strategies that could be as simple as alternating the injected arm from year to year, or alternating inhaled vs. injected forms of vaccine. this will be a 4 armed prospective study of individuals receiving unilateral flushield i.m. healthy adult volunteers 21-55 will be grouped according to the following criteria: i. documented history of prior natural infection with influenza a or b within the past 5 years (diagnostic test or high titer hemagglutinin ha ab in absence of vaccination); ii. history of flumist vaccination within the past 2 years; iii. history of tiv (trivalent (inactivated) influenza vaccine) vaccination, any number of times, but only in a single (e.g., non-dominant) arm. within one month of screening and baseline blood draws for pbmcs (peripheral blood mononuclear cells) and ab (antibody) titers, individuals will receive flushield injections. for those individuals with prior history of unilateral tiv injections, half will receive their shots in the same arm that has always been injected (group iiia). the other half of these individuals will receive flushield in the opposite (dominant) arm (group iiib). upon entering the study, 50cc of heparinized blood and 10 cc of serum will be drawn by antecubital venipuncture. within 4 weeks of this blood draw, volunteers will receive a standard dose of i.m. tiv (flushield). four-seven days later they will have an fdg pet-ct scan performed after an 8 hour fast. additional blood draws of 50cc heparinized blood and 10 cc serum will be obtained at 2, 4, and 6 weeks post vaccination, and at 10-12 months post vaccination. after the last blood draw, volunteers will also be asked questions pertaining to flu-like symptoms during the past 10 months.

Eligibility criteria:
inclusion criteria: * men and women 21-55 years old. * willingness to participate in the study for a full year including multiple blood draws and pet-ct scanning exclusion criteria: * diabetes * use of systemic steroids * pregnancy or unwillingness to practice birth control of some kind through the pet-ct scanning period * recent vaccination for other reasons (e.g., traveler's vaccines) * significant intercurrent illness that might interfere with vaccination "take" or interpretation of pet-ct scanning (e.g., chemotherapy for cancer)

Keywords: influenza flu vaccine vaccination immune response flushield flumist pet-ct healthy volunteers
cthrc1: a biomarker for evaluation of rheumatoid arthritis disease activity

Conditions: Rheumatoid Arthritis

Summary: the purpose of the study is to determine whether plasma levels of the collagen triple helix repeat containing (cthrc1) protein can serve as a blood-based biomarker for diagnosis of rheumatoid arthritis (ra) ,and furthermore its correlation with disease activity

rheumatoid arthritis (ra) is a chronic, progressive, autoimmune disease of synovial joints. characterized by periods of flares with high disease activity involving both a systemic immune response and tissue-specific inflammatory events that can lead to erosive joint and bone destruction and subsequent disability . currently, diagnosis of ra is based mainly on the extent of tenderness and swelling of the joints , levels of acute-phase reactants such as c-reactive protein (crp) ,erythrocyte sedimentation rate(esr) , high titers of rheumatoid factor (rf) and high titers of antibodies against cyclic citrullinated peptide (anti-ccp) in the plasma .recently, reported increased levels of collagen triple helix repeat containing 1 protein (cthrc1) are strongly associated with the severity of murine proteoglycan-induced arthritis and collagen antibody-induced murine arthritis (caia) , further cthrc1 expression in murine experimental arthritis is increased in the synovium and specifically detected in activated murine , located at the synovial intimal lining and at the bone-pannus interface .of interest,the expression pattern of cthrc1 in pannus, its role in the function of fls relevant to cartilage damage in ra, and cthrc1's association with disease severity in murine arthritis raised the question of whether cthrc1 could be used as a marker for ra diagnosis and monitoring of disease activity in patients .

Eligibility criteria:
inclusion criteria: * patients diagnosed as ra * age more than 18 years exclusion criteria: * other rheumatological diseases malignancies hepatic diseases
leflunomide versus azathioprine for maintenance therapy of lupus nephritis

Conditions: Nephritis; Lupus

Summary: leflunomide versus azathioprine for maintenance therapy of lupus nephritis

proliferative glomerulonephritis is a common and severe manifestation of systemic lupus erythematosus (sle) that usually requires intensive therapy with high doses of glucocorticosteroids and cytotoxic drugs, such as intravenous (iv) cyclophosphamide (cyc). the objective of this trial is to compare leflunomide (lef) and azathioprine (aza), in terms of efficacy and toxicity, as remission-maintaining treatment of proliferative lupus glomerulonephritis, after a remission-inducing therapy with a short-course iv cyc regimen. the hypothesis of this trial is that lef is non-inferior to aza.

Eligibility criteria:
inclusion criteria: * aged 18 to 65 years * biopsy-proven proliferative lupus nephritis * disease activity, sledai score ≥ 8 points * persistent proteinuria (≥ 1g/24h), with or without microscopic hematuria; * signed informed consent exclusion criteria: * allergy to the lef, ctx, aza * recent treatment with high-dose glucocorticoids * weight \<45kg * recent treatment with immunosuppressive drugs * cns( central nerve system) lupus patients * hepatic failure patients * severely abnormal renal function or end-stage renal failure * more exclusion criteria in the protocol

Keywords: lupus nephritis leflunomide azathioprine
regulation of katp channels and na+/k+ atpase in relation to fatigue development

Conditions: Insulin Resistance

Summary: to investigate the role of atp sensitive k+ potassium channels and the na+/k+ pump in the development of fatigue in healthy and in insulin resistant subjects.


Eligibility criteria:
inclusion criteria: * non smokers * hba1c \ 1.7 (insulin resistant) * vo2max \<40 ml/kg/min (insulin resistant), 45-55 ml/kg/m2 (healthy) * bmi \>26 kg/m2 (insulin resistant), 19-26 kg/m2 (healthy) exclusion criteria: * use of antidiabetic medication or any other medication deemed to interfere with study outcomes * allergy towards nicorandil * chronic disease other than type 2 diabetes deemed to interfere with study outcomes * excessive alcohol consumption (\>14 units/week) * abnormal ecg

Keywords: skeletal muscle muscle fatigue ion handling
efficacy of pegamotecan (peg-camptothecin) in localized or metastatic cancer of the stomach or gastroesophageal junction

Conditions: Cancer of Stomach; Gastroesophageal Cancer

Summary: the purpose of this study is to evaluate the safety and efficacy of pegamotecan (peg-camptothecin) in patients with pathologically-diagnosed locally advanced or metastatic adenocarcinoma of the stomach or gastroesophageal junction who have relapsed or progressed following one prior chemotherapy treatment regimen.


Eligibility criteria:
inclusion criteria: * pathologically confirmed diagnosis of adenocarcinoma of the stomach or gastroesophageal junction. * disease measurable in at least one dimension. * target tumors outside of prior radiation field(s). * an eastern cooperative oncology group (ecog) performance scale score of 0 or 1 * adequate hematologic profile, as determined by hemoglobin, platelet, and neutrophil count. * adequate renal function, as determined by serum creatinine and serum albumin measurements. * adequate liver function, as determined by total bilirubin and transaminases levels. transaminases may be \<= 5.0x uln if due to metastatic disease in the liver. * fully recovered from prior surgery. * no history of hemorrhagic cystitis. * no microscopic hematuria (\>10 rbc/hpf) unless documented to be due to an infection or non-bladder origin. * capable of understanding the protocol requirements and risks and providing written informed consent. exclusion criteria: * concurrent serious medical illness unrelated to tumor within the past 6 months. * known chronic infectious disease, such as aids or hepatitis (screening for hepatitis and hiv will not be performed). * positive screening pregnancy test or is breast-feeding. * female or male subject of reproductive capacity who is unwilling to use methods appropriate to prevent pregnancy during the course of this study. * receiving concurrent chemotherapy, investigational agents, radiotherapy, surgery, or has received wide field radiation within the previous 4 weeks. * history of another malignancy (except basal and squamous cell carcinomas of the skin and carcinoma in situ of the cervix) within the last 5 years. * known or clinically suspected brain metastases. * received more than one prior regimen of chemotherapy for locally advanced or metastatic adenocarcinoma of the stomach or ge junction. * received prior neoadjuvant and/or adjuvant cytotoxic chemotherapy * received any investigational drug within the last 30 days. * not fully recovered from any prior, and from any reversible side effects related to the administration of cytotoxic chemotherapy, investigational agents, or radiation therapy. * prior treatment with a camptothecin analog.

Keywords: cancer gastric gastroesophageal junction neoplasms gastric cancer gastric neoplasms
electronic archive of internal medicine for the treatment of severe organ failure and liver transplantation-mitigo

Conditions: Organ Failure, Multiple; LIVER TRANSPLANTATION

Summary: electronic archive of internal medicine for the treatment of serious organ failures and liver transplantation

this is an observational, spontaneous, monocentric study with structured data collection from the medical records of patients diagnosed with acute or chronic liver failure. the study will involve both retrospective and prospective data collection: retrospective data collection: patients diagnosed between 01/01/2013 and the start date of the study. prospective data collection: patients diagnosed after the start of the study until the end of the recruitment period (10 years).

Eligibility criteria:
inclusion criteria: * diagnosis of acute or chronic liver disease or lt * age ≥ 18 years * obtaining informed consent exclusion criteria: * no one
quality assurance via telephone interviews after cataract surgery

Conditions: Cataract

Summary: to analyse quality assurance after cataract surgery by assessing discomfort and other symptoms via telephone interviews either in the evening of the day of the surgery or 1 day after surgery versus no additional call after surgery.

as there is a trend towards shorter hospital stays, an increasing number of patients is leaving the hospital the same day after cataract surgery. there may be questions or complaints after the patients' dismissal after cataract surgery, consequently it might be useful to call patients at the day or one day after surgery in order to ask them about their concerns. in general, possible complications after cataract surgery are explained to patients already before surgery and patients often receive additional written information. but as patients may still be uncertain whether it would be beneficial to visit a doctor in case of problems, it might be useful to call the patients and if necessary, advise them to see a doctor. during the phone call patients have the opportunity to ask more questions if something still does not seem clear. for patients who are scheduled for cataract surgery for both eyes, the routine procedure is as follows: if cataract surgery is scheduled for both eyes, in general the surgeries are performed one week apart. cataract surgery is usually performed under local anaesthesia and the patient can leave the department on the same day. when patients arrive at the department of ophthalmology for the second surgery, doctors evaluate the condition of the eye, operated the week before. after each surgery of each eye patients receive a prescription of topical medication. it is recommended to see the referring ophthalmologist within a week after the procedure. in case of problems or complaints patients are always told to see a doctor immediately. a respective written information is given to the patients. during this study we plan to call patients, who are scheduled for cataract surgery for both eyes, in the evening of the day of the surgery or one day after the surgery of the first eye and to ask questions about their current condition for quality assessment. when people return for cataract surgery of the second eye, a questionnaire will be handed out to the patients. this questionnaire includes questions concerning problems after surgery of the first eye, visits in outpatint clinics and about their satisfaction with the phone call after the surgery of the first eye. in this study 200 patients will be included: 100 patients will receive a telephone call (50 in the evening of the day of the surgery, 50 one day after surgery) and 100 patients who will not receive a phone call.

Eligibility criteria:
inclusion criteria: * men and women aged 18 and older * planned cataract surgery of both eyes * good knowledge of the german language

Keywords: telephone call