Kornimate/medical-research-clean huggingface dataset:
smokerface mirroring in brazil rct

Conditions: Smoking

Summary: before february 2018 the baseline survey is conducted in about 60 class in brazilian secondary schools. these classes are randomized to control and intervention group in a 1/1 manner. a few weeks thereafter medical students from the local medical school visit the schools and perform a smoking prevention intervention called "photoaging mirroring intervention" which takes about 45 minutes. one month and six months after the intervention the intervention group receives another anonymous questionnaire monitoring smoking status. the primary endpoint is the difference in the chance of smoking prevalence between the two groups.

before february 2018 the baseline survey is conducted in about 60 class in brazilian secondary schools. these classes are randomized to control and intervention group in a 1/1 manner. a few weeks thereafter medical students from the local medical school visit the schools and perform a smoking prevention intervention called "photoaging mirroring intervention" which takes about 45 minutes. one month and six months after the intervention the intervention group receives another anonymous questionnaire monitoring smoking status. the primary endpoint is the difference in the chance of smoking prevalence between the two groups.

Eligibility criteria:
inclusion criteria: visiting a brazilian secondary school exclusion criteria: not visiting a brazilian secondary school
ixiaro as booster after mouse-brain derived vaccines for japanese encephalitis

Conditions: Japanese Encephalitis

Summary: the old mouse brain derived japanese encephalitis vaccines (mbjev) have been reported to cause serious adverse effects and are therefore replaced with the novel ixiaro vaccine. the present study investigates whether vaccinees primed with mbjev can be boosted with ixiaro. travellers receiving japanese encephalitis vaccines are enrolled for a follow-up of immune responses in four groups: a) primary immunization with bmjev, b) primary and secondary immunizations with mbjev, c) primary immunizations with ixiaro and s) primary immunization with mbjev and secondary immunization with ixiaro. immune responses are followed with help of serum samples collected before and after vaccination.


Eligibility criteria:
inclusion criteria: * male and female travellers ≥ 18 years of age. * general good health. * written informed consent. * ability to attend all visits scheduled in this study. * travellers who have previously got a primary vaccination series of 2 or 3 doses of je-mb and now receive a booster vaccination , either mb-jev or ixiaro, at the travel clinic for their journey to asia, or * travellers with no previous vaccination against je who are given the primary vaccination series with ixiaro at a travel clinic prior to their journey to asia. exclusion criteria: * - \< 18 years of age. * acute disease at the time of enrollment. * pregnancy or lactation. * known immunodeficiency or immune suppressive treatment. * any chronic illness that might interfere with the immune response; history of je. * alcohol or drug abuse. * any clinically significant history of known or suspected anaphylaxis or hypersensitivity (based on the investigator's judgement).

Keywords: ixiaro japanese encephalitis vaccine booster
using virtual reality before transcranial magnetic stimulation for the treatment of ocd

Conditions: Obsessive-Compulsive Disorder

Summary: this study will focus on the use of virtual reality (vr) technology in patients receiving treatment using transcranial magnetic stimulation (tms) for obsessive-compulsive disorder (ocd)


Eligibility criteria:
inclusion criteria: * participants must be at least 18 years old * patients must have been clinically evaluated by a yale interventional psychiatry service physician who has deemed them appropriate to receive tms for the treatment of ocd * ability and willingness, in the investigator's judgement, to comply with the study procedure and study requirements. exclusion criteria: * hearing or visual impairment to the degree that would interfere with ability to see or hear vr content. * difficulty in understanding spoken or written english * pregnancy * history of seizure disorder * unable to provide informed consent * dementia or other cognitive disorder or intellectual disability that would impair the subject's ability to understand the study procedure (per investigator judgment) * any implanted medical device, risk of interference with which by the vr device in the investigator's judgment can put patient at additional undue risk. * any other medical or psychiatric comorbidity that the investigator judges would put the participant at additional undue risk due to study participation or would impair subject's ability to participate in the study. * was previously enrolled/randomized into the study

Keywords: tms transcranial magnetic stimulation virtual reality vr
facial and body motion technology and stroke

Conditions: Stroke

Summary: the purpose of this study is to customize privacy protected facial expression and body motion tracking for use in the home environment by stroke survivor-informal caregiver dyads by investigating within a simulated home environment, background variability,possible occlusions, privacy considerations, and the motor weaknesses, gait impairments, and facial expressions of stroke survivors and to determine the acceptability of the customized facial expression and body motion technology in stroke survivors and their informal caregivers.

stroke is a leading cause of disability. most stroke survivors are discharged home after hospitalization and receive care from informal caregivers (e.g., unpaid spouses) who are often unprepared for the role. stroke survivorship is an exemplar of a chronic condition that detracts from the affected individual and caregiver's capacity to live well within the home (e.g., psychosocial distress). early identification of psychosocial distress is likely to lead to timely interventions and, subsequently, decreases in associated morbidity, mortality, and disability. yet, only a minority of survivors are properly identified and treated for psychosocial distress, and caregivers are primarily forgotten. in-home, objective measures to identify psychosocial distress are lacking. using facial expression and body motion technology by extracting facial characteristics and body joints (skeletal graph) known to be associated with psychosocial distress (e.g., frowning) provides new opportunities to support in-home telemonitoring. to accommodate real-world, post-stroke home environments, the technology needs to be customized to an in-home environment. toward this end, the investigators must consider background variability, possible occlusions, privacy concerns, and stroke survivor motor weaknesses, gait impairments, and facial paralysis. objectives: the primary objectives are to customize facial expression and body motion technology and examine the acceptability of the technology through a study of 6 stroke survivor-informal caregiver dyads within a simulated home environment. the project will serve as a necessary step to amass critical information to design future trials using facial expression and body motion technology. the ultimate goal is to improve psychosocial well-being for those aging at home.

Eligibility criteria:
inclusion criteria: * can read, write, and speak english * are willing and able to provide informed consent * informal caregivers must live in the home with the stroke survivor and be unpaid for their role * stroke survivors must have some degree of facial and limb weakness and a modified rankin scale (mrs)13 score between 1 and 3. exclusion criteria: - stroke survivors currently reside outside of the home and are wheelchair bound.

Keywords: stroke caregiver technology psychosocial aging
diode laser therapy as an adjunct to scaling and root planing

Conditions: Chronic Periodontitis

Summary: laser therapy has been proposed as a novel treatment option in controlling subgingival microorganisms. this randomized controlled clinical trial evaluates the effect of 980nm diode laser as an adjunct to scaling and root planing (srp) in the management of chronic periodontitis (cp).

conventional mechanical debridement can achieve a temporary decrease in the subgingival levels of pg along with other pathogens. however, mechanical therapy alone may fail to eliminate pathogenic bacterial niches in inaccessible areas like deep pockets, root concavities, furcation areas etc. in search of more efficient and less traumatic techniques to improve periodontal healing, researchers proposed the use of lasers in periodontal therapy. the adjunctive use of lasers with conventional tools may facilitate treatment and have the potential to improve healing. the diode laser is highly absorbed in hemoglobin and other pigments and is excellent for use in soft tissue surgical procedures.laser application in improving clinical outcome in periodontal therapy, needs to be further investigated with well designed clinical trials. the investigators attempted to evaluate the efficacy of diode laser as an adjunct to srp in the management of cp by evaluating clinical parameters coupled with quantitative estimation of p.gingivalis using real-time polymerase chain reaction (rt-pcr) assay.

Eligibility criteria:
inclusion criteria: * 40 systemically healthy subjects diagnosed with generalized moderate cp in the age group of 30 to 50 years. * minimum of 20 teeth having atleast two non-adjacent sites per quadrant with probing pocket depth of ≥ 5mm and clinical attachment loss of 3- 4 mm exclusion criteria: * patients who had undergone periodontal therapy 6 months prior to the commencement of the study. * subjects on antibiotics or immunosuppressants. * chronic smokers, alcoholics, smokeless tobacco users. * subjects with acute illnesses/acute intraoral lesions. * pregnant women * subjects who had undergone extensive restorative dental treatment.
efficacy of pantoprazole in patients older than 18 years who have symptoms of non-erosive reflux or gastroesophageal reflux disease (by1023/de-004)

Conditions: Gastroesophageal Reflux

Summary: the aim of the study is to evaluate the effect of pantoprazole on fast symptom reduction in hospitalized patients with nerd (non-erosive reflux disease) or gerd (gastroesophageal reflux disease, los angeles \[la\] grade a-d). during the study, the patients will complete a patient-orientated, self-assessed reflux questionnaire (request™). the study duration consists of a treatment period of 7 days ± 3 days. pantoprazole (tablet) will be administered once daily in the morning to patients with nerd or gerd at one dose level for each indication. the study will provide further data on the safety and tolerability of pantoprazole.


Eligibility criteria:
main inclusion criteria: * written informed consent * inpatients (hospitalization during the entire study period is mandatory) * symptomatic (heartburn, acid regurgitation or dysphagia for at least 1 day since admission to the hospital) non-erosive reflux disease (nerd) or erosive gastroesophageal reflux disease (gerd, la grade a-d) main exclusion criteria: * known zollinger-ellison syndrome or other gastric hypersecretory condition * previous acid-lowering surgery or other surgery of the esophagus and/or upper gastrointestinal tract (exception: polypectomy and cholecystectomy) * on initial endoscopy, presence of obstructive esophageal strictures, schatzki's ring, esophageal diverticula, esophageal varices, achalasia or barrett's esophagus with known high-grade dysplasia or longer than 3 cm * acute peptic ulcer and/or ulcer complications * pyloric stenosis * known inflammatory bowel diseases

Keywords: gerd pantoprazole nerd
improving the function of the foot by core foot system (cfs) exercise theory in patients after hallux valgus surgical procedure

Conditions: Hallux Valgus

Summary: the aim of the study is to identify the impact of cfs foot muscle training on time-space parameters, anthropometric parameters and bioelectrical activity (emg) of the foot muscles during walking and to develop an algorithm for an effective therapeutic method in patients after hallux valgus correction. achieving the purpose of the research will contribute to the answer to the following research questions: * does the cfs therapy used significantly change the arch of the foot in hv patients compared to the control group? * does the cfs therapy used significantly improve gait characteristics after hv surgery in relation to the control group? * does muscle stimulation and the moment of their activation differ in groups in which different therapies have been used? * will the results of the questionnaires and scale be significantly different in both groups?


Eligibility criteria:
inclusion criteria: * hallux valgus deformity * surgical procedure * voluntary consent to the study exclusion criteria: * lack of consent to research * other deformation and operations of the foot * pain after the surgery which prevents experimental procedure

Keywords: hallux valgus core foot system rehabilitation protocol
safety study of imexon plus gemcitabine in untreated pancreatic adenocarcinoma

Conditions: Pancreatic Adenocarcinoma

Summary: amp-004 is a phase 1b dose escalation trial designed to evaluate the safety of the new drug imexon in combination with an approved drug, gemcitabine, for the treatment of patients with previously untreated pancreatic cancer. the treatment consists of dosing with both imexon and gemcitabine on days 1, 8, and 15 of each 28 day cycle. the study is designed to determine the highest doses of the two drugs that can be safely combined together.


Eligibility criteria:
inclusion criteria: * inoperable cancer of the pancreas. * blood cell counts and blood chemistries in or near normal range. * able to perform the activities of daily living. * a projected life expectancy of at least 2 months. * if female, neither pregnant nor nursing. * willing to use contraceptives to prevent pregnancy. * no other serious illnesses. * no other active malignancy. * no serious infections. * no current other drug therapy for the cancer or steroid therapy. * prior radiation is permitted as is chemotherapy given during radiation or to prevent relapse after surgical removal of the disease. exclusion criteria: * prior chemotherapy for metastatic disease. * brain metastases
long-term outcome of laparoscopic hiatal hernia repair with or without alloderm mesh at a university hospital

Conditions: Gastroesophageal Reflux Disease; Hiatal Hernia; Paraesophageal Hernia

Summary: to study the long term outcome of laparoscopic hiatal hernia repair with human acellular dermal matrix alloderm (lifecell, branchburg, nj) mesh.

to study the long term outcome of laparoscopic hiatal hernia repair with human acellular dermal matrix alloderm (lifecell, branchburg, nj) mesh. a barium swallow test with x-rays will be performed to look for recurrence of hiatal hernia. if the participants are symptomatic, additional medical therapy will be provided as deemed appropriate.

Eligibility criteria:
inclusion criteria: * subjects who underwent paraesophageal hernia repair at unmc. * greater than 19 years of age * not pregnant exclusion criteria: * children and adolescents * pregnant and breast-feeding patients * vulnerable subjects such as decisionally impaired persons

Keywords: gerd hiatal hernia paraesophageal hernia biologic mesh
optical frequency domain imaging vs. intravascular ultrasound in percutaneous coronary intervention

Conditions: Coronary Artery Disease

Summary: the aim of this randomized study is to evaluate the impact of optical frequency domain imaging (ofdi) guidance for percutaneous coronay intervention (pci) with drug-eluting stent (des) as compared with intravascular ultrasound (ivus) guidance.

optical frequency domain imaging (ofdi) is a novel, high resolution intravascular imaging modality. intravascular ultrasound (ivus) is a widely used conventional imaging modality for achieving optimal stent deployment. the aim of this randomized study is to evaluate the impact of ofdi guidance for percutaneous coronay intervention (pci) with drug-eluting stent (des) as compared with ivus guidance. we will enroll 800 patients with a de novo lesion who will undergo pci with des as is routine practice. patients will be rondomely assigned to either ofdi-guided pci arm or ivus-guided pci arm. patients will then have a follow-up contact at the time of hospital discharge, 8 month and 12 month after pci.

Eligibility criteria:
inclusion criteria: * patients with a de novo lesion (in the native coronary circulation) and planned to undergo drug-eluting stent implantation for indications according to the japan and usa guidelines * patients aged between 20 and 85 years old * patients who has provided written informed consent exclusion criteria: * patients with acute myocardial infarction (ami) within 3 months * patients with cardiogenic shock * patients with chronic heart failure * patients with renal failure (egfr \ =1.5mg/dl) * patients who are currently enrolled in other clinical trial which has possibility to influence the primary endpoint of opinion trial. * patients planned use of bare metal stent * patients with 3-vessel diseases * planned surgery within 1 year * patient on dialysis * target lesion such as: * left main coronary artery * aorto-ostial lesion location within 3mm of the aorta junction * chronic total occlusion * small vessel (reference vessel diameter \<2.5mm) * coronary artery bypass graft

Keywords: coronary artery disease percutaneous coronary intervention optical frequency domain imaging intravascular ultrasound
aids-associated cardiomyopathy

Conditions: Acquired Immunodeficiency Syndrome; Heart Diseases; Myocardial Diseases; HIV Infections

Summary: to define the incidence and prevalence of aids-associated cardiomyopathy. also, to conduct immunopathology and serologic studies in endomyocardial biopsies and autopsy tissues.

background: in 1988, the leading cause of death in aids patients was respiratory mechanisms might have played a significant role in its pathogenesis. the project was part of an institute-initiated study on aids-associated heart disease in adults. the concept was approved by the national heart, lung, and blood advisory council in september 1987. the request for applications was also released in september 1987. awards were made in july 1988. design narrative: the prevalence study was one of three subprojects with the common failure due to chronic opportunistic pulmonary infection, primarily pneumocystis carinii pneumonia. drugs such as azidothymidine (azt) and trimetrexate showed some effectiveness in prolonging the lives of some aids patients. with increased survival, it was believed that cardiac diseases might well become an important complication of aids. reports described a syndrome of rapidly progressive cardiomyopathy associated with aids. the etiology of aids-associated cardiomyopathy was yet unknown although immunologic theme of the immunopathogenesis of aids-associated cardiomyopathy. the other two subprojects dealt with immunopathology studies in endomyocardial biopsies and autopsy tissues and serologic studies. the aids clinical research center at johns hopkins hospital served as the source of patients. all patients underwent serologic testing and echocardiography at time of entry and at six and twelve months. the screening electrocardiogram identified 40 to 50 patients per year with aids-associated cardiomyopathy. approximately 30 patients per year had no contraindications for endomyocardial biopsy. comprehensive tissue studies and cellular immune studies were performed on the cohort and autopsies, if possible. immunohistochemical techniques and in situ hybridization of biopsy and autopsy material were used to determine if aids-associated cardiomyopathy was associated with hiv infection of the heart or with some other viral or opportunistic non-viral infection. indirect immunofluorescence and a western immunoblotting assay using patient sera determined the prevalence of heart autoimmunity. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
the effect of jazz on postoperative pain and stress in patients undergoing elective hysterectomy

Conditions: Pain; Anxiety

Summary: the purpose of this study is to investigate the effects of music on patients after surgery in the post anesthesia care unit (pacu). for many patients, surgery creates significant emotional stress and anxiety which can include discomfort or pain. music therapy has proven to be a useful adjuvant in various inpatient and outpatient settings by providing a relaxing effect that decreases heart rate, blood pressure, and hormonal measures of stress. it has been shown that classical music can cause physiological and psychological differences in patient outcomes, but few studies have looked specifically at effects of jazz music. some have argued that jazz may be too involved to provide the same relaxed state as classical music, but this may be due in part to the type of jazz played for the patient. it is our hypothesis that slow jazz music by artists including miles davis, ella fitzgerald, diana krall, dave brubeck, etc. will reduce measures of stress and anxiety in patients in the pacu following surgery for hysterectomy (laparoscopic or robotic) to a greater extent than the control group. jazz music or "no music" will be played through headphones to participants in the study post-surgically while they are in the pacu and measures of stress, anxiety, and pain will be monitored.

* patients will be identified the morning of surgery from the operating room schedule. * the patients will be randomized to two groups: jazz music or no music. * head phones will be applied to all patients included in the study; in one group jazz music will be provided through the headphones. the second group no music will be played. * blood pressure will be monitored by a non-invasive blood pressure cuff at 5 minute intervals throughout the patient's stay in the pacu. * heart rate will be measured, using a pulse oximeter, at the same intervals as blood pressure. * before the patient leaves the pacu, she will be asked to rate her perception of her levels of pain and anxiety on scales that use a numeric scale of 1-10. the primary variable outcomes are: heart rate and mean blood pressure. secondary outcomes include: perceived pain, anxiety, and level of relaxation. * headphones will be used to deliver one of the following sounds to the patients: 1) jazz music (bpm\<100) by artists including miles davis, ella fitzgerald, diana krall, dave brubeck, etc.; or 2) no music providing.

Eligibility criteria:
inclusion criteria: * undergoing elective hysterectomy (laparoscopic or robotic) * asa 1 or 2 * normotensive * normal heart rate exclusion criteria: * patient does not wish to participate in the study * deaf or hearing impaired patients * ear deformities or abnormalities * pre-existing diagnosis of anxiety disorder, depression, substance abuse, or any other psychiatric diagnoses

Keywords: music stress anxiety post-surgical pain