Kornimate/medical-research-clean huggingface dataset:
evaluating the relationship between fatty acids and heart disease

Conditions: Cardiovascular Diseases; Heart Failure, Congestive; Atrial Fibrillation; Cerebrovascular Accident

Summary: cardiovascular disease (cvd) affects millions of people in the united states; each year, more people die from cvd than from any other disease. individuals with low levels of n-3 fatty acids and high levels of trans-fatty acids may have an increased risk of developing cvd. this study will evaluate the link between fatty acids and the presence of cvd in older adults.

cvd includes diseases that affect the heart and blood vessels, including congestive heart failure (chf), atrial fibrillation (af), and stroke. cvd may be associated with low levels of n-3 fatty acids and high levels of trans-fatty acids, but more research is needed to determine the role of various fatty acids in the development of cvd. results from prior studies on this topic have not always been reliable because data from self-reported dietary questionnaires on fatty acid intake have sometimes been inaccurate. a more effective way to measure levels of fatty acids is to analyze blood samples. this study will use blood samples of participants in the cardiovascular health study, a study that examined cvd risk factors in older adults, to determine the link between various fatty acids and the incidence of chf, af, and stroke. the results from this study may help researchers identify the dietary factors that influence the development of cvd in older adults. this study will examine previously collected data from participants in the cardiovascular health study. there will be no study visits specifically for this study. plasma samples obtained from participants will be analyzed for the presence of n-3 fatty acids and trans-fatty acids. the study will also determine the incidence of chf, af, and stroke and the way in which fatty acids are related to hemodynamics, heart structure and function, electrophysiology, insulin sensitivity, inflammation, endothelial function, and obesity.

Eligibility criteria:
inclusion criteria: * participated in the cardiovascular health study

Keywords: stroke
effect of serving size and addition of sugar on the glycemic response elicited by oatmeal

Conditions: Diabetes Mellitus

Summary: the purpose of this study was to determine the impact of serving size and the addition of sugar on the glycemic response elicited by oatmeal compared to that elicited by cream of rice cereal.


Eligibility criteria:
inclusion criteria: * body mass index (bmi) 20.0 - 34.9 kg/m² exclusion criteria: * known to have diabetes * use of medications considered by the principal investigator to influence glycemic responses

Keywords: blood glucose humans postprandial sugar carbohydrate oat beta-glucan
surgical conversion of candonilimab (ak104) plus paclitaxel, s-1 and apatinib for unresectable advanced g/gej cancer

Conditions: Gastric Cancer

Summary: this is a prospective, single-arm, open-label，single-center, phase ii study, aiming to to evaluate the surgical conversion feasibility of ak104 combined with apatinib, paclitaxel and s-1 in unresectable stage iv g/gej cancer.

eligible patients receive ak104 (10mg/kg, iv, q3w) combined with apatinib (250mg, po, qd), paclitaxel (non-peritoneal metastasis: 130mg/m2, iv, d1; peritoneal metastasis :90mg/m2, iv, 40mg/m2, ip, d1) and s-1(60mg, po, bid, d1-d14) for up to 6 cycles. patients assessed by multi-disciplinary treatment (mdt) to meet the criteria for surgical resection undergo gastrectomy.

Eligibility criteria:
inclusion criteria: 1. males or females aged ≥ 18 to ≤ 75 years at the time of signing informed consent. 2. clinically diagnosed unresectable stage iv gastric (g) or gastroesophageal junction (gej) adenocarcinoma by ct/mri/positron emission tomography (pet) -ct. 3. not received prior systemic therapy for stage iv g/gej adenocarcinoma 4. at least one measurable tumor lesion per recist v1.1; 5. major organ functions are adequate; 6. expected survival is ≥ 3 months; 7. eastern cooperative oncology group performance status (ecog ps) 0-1; exclusion criteria: 1. human epidermal growthfactor receptor 2 (her2)-positive g/gej adenocarcinoma; 2. previously received immune checkpoint inhibitors, including but not limited to programmed death 1 (pd-1) inhibitors and cytotoxic t lymphocyte-associated antigen-4 (ctla-4) inhibitors; 3. central nervous system, lung, or bone metastases; 4. known history of active or autoimmune disease; 5. known history of other malignancies; 6. known history of severe cardiovascular and cerebrovascular diseases; 7. known history of gastrointestinal bleeding within the past 3 months or significant tendency to gastrointestinal bleeding; 8. active infection or fever of unknown origin; 9. known history of pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonitis, drug-related pneumonia, and severe impairment of lung function; 10. known history of immunodeficiency, positive hiv antibody (hivab) test, or other acquired or congenital immunodeficiency disorder, or active hepatitis; 11. known history of mental disorder or psychoactive substance abuse; 12. hypersensitivity to the drugs of this regimen;
ultrasound guided diagnostic lumbar medial branch blocks

Conditions: Back Pain

Summary: can an ultrasound machine be used to perform a diagnostic lumbar medial branch block?

the diagnostic lumbar medial branch block for low back and radiating to lower extremity due to lumbar facet joint pain has been traditionally done under fluoroscopic guidance. some recent studies have shown that the diagnostic lumbar medial branch may alternatively be done under ultrasound guidance. this proposed technique has many advantages, avoid radiation exposure and decrease waiting period for patients to have a pain procedure for low back pain. the time taken, patients' satisfaction score, pain score, the distance the needle tip placed under ultrasound and the ideal position visualized under fluoroscopy will be measured. this study will be done in 2 parts. the first part will determine landmarks for ultrasound. it will involve using 5 cadavers. the second part of the study will involve 25 patients. the needles will be placed initially with ultrasound and then will be verified with c-arm fluoroscopy. certain criteria will be used to determine its feasibility, for example, less than 20 minutes, less than 5 mm.

Eligibility criteria:
inclusion criteria: * low back and/or leg pain due to possible lumbar facet joint disease exclusion criteria: * patient with bmi\>35 * coagulopathy * allergy to local anesthetic and ultrasound gel * patient unable to fill out post procedure pain diary

Keywords: ultrasound diagnostic lumbar median branch block lumbar facet joint pain
assessment of relationship between preoperative nutritional status and perioperative/postoperative conditions in patients with lung cancer scheduled for lobectomy

Conditions: Lung Cancer; Malnutrition; Nutritional Deficiency

Summary: malnutrition is common in patients with lung cancer. in patients with malnutrition risk, the risk of complications is high both in the perioperative, early and late postoperative periods. malnutrition is an independent risk factor for length of hospital stay and cost in these patients. patients with lung cancer may have many morbidities in postoperative period, especially problems with wound healing. therefore, assessment of the nutritional status of patients with lung cancer should begin at the diagnosis stage.

in patients with lung cancer scheduled for lobectomy, anthropometric measurements will be measured and the results of laboratory tests(albumin, prealbumin, creatinine, total lymphocyte count, c reactive protein), nutritional risk screening-2002, nutritional risk index, mini nutritional assessment, glasgow prognostic score, prognostic nutritional index and neoadjuvant chemotherapy or not will be recorded in 72 hours before surgery. in addition, demographic information of the patients (name, surname, identification number, age, comorbidity, american society of anesthesiologists score) will be recorded. after the information is given to the patients, their written and verbal consent will be obtained. in the operating room, routine monitoring (electrocardiography, invasive blood pressure measurement, arterial blood gas monitoring, peripheral oxygen saturation, end-tidal carbon dioxide measurement by capnography) will be applied to the patients in accordance with the standard protocol for elective lobectomy surgery. hemodynamic changes (eg. dysrhythmia, hypotension, hypertension, hemorrhage), metabolic status (ph, bicarbonate, base excess), lactate, glucose level in blood gas evaluation and intraoperative complications will be recorded during the intraoperative period. in the postoperative period, length of stay in the intensive care unit, length of hospital stay, early complications (eg. dysrhythmia, acute coronary syndrome, sepsis, mediastinitis, pneumonia, surgical site infection, prolonged air leak), time to start oral intake and transition to adequate oral intake will be recorded in the one-month postoperative period.

Eligibility criteria:
inclusion criteria: * having a diagnosis of lung cancer * lung lobectomy operation will be performed * 18 years and older patients * having an american society of anesthesiologists score of 1, 2, 3 * having approved and signed the informed consent form exclusion criteria: * patients who underwent lobectomy with a diagnosis other than lung cancer * patients younger than 18 years * patients with an american society of anesthesiologists score of 4 and above * patients who did not accept informed consent * patients who refused to participate in the study
probiotic saccharomyces boulardii for the prevention of antibiotic-associated diarrhoea

Conditions: Antibiotic-associated Diarrhea; Clostridium Difficile; Diarrhea

Summary: when patients in hospitals receive antibiotics they often develop diarrhoea. the consequences may be grave for the patient. thus far, no preventive measure is available. the investigators hypothesize that the apathogenic yeast saccharomyces boulardii, administered in addition to the antibiotic, may prevent episodes of diarrhoea or may lead to less pronounced diarrhoea. to test this hypothesis, the investigators are carrying out a clinical trial in 1520 adult patients in several hospitals.

antibiotic-associated diarrhoea (aad) is a frequent condition in hospitalised patients receiving antibiotic treatment. the same is true for clostridium difficile-associated diarrhoea (cdad) with even more grave consequences of increased morbidity and mortality. the development and evaluation of preventive strategies is one key public health challenge. in the absence of clinically evaluated alternatives, probiotics have been suggested to be beneficial for the prevention of aad and cdad. however, data have so far been inconclusive and recently published meta-analyses strongly recommended large state-of-the-art clinical trials on probiotic substances for the prevention of aad and cdad. since the efficacy, side-effects and modes of action of different probiotic bacteria and yeast are strain specific, benefits and risks cannot be generalised. the non-pathogenic yeast saccharomyces cerevisiae var. boulardii (sac. boulardii) is considered the most promising probiotic substance for the prevention of aad and cdad. we carry out a randomised, placebo controlled, double blind multicentre clinical trial to evaluate sac. boulardii for the indication of prevention of aad and cdad in 1520 adult, hospitalised patients.

Eligibility criteria:
inclusion criteria: * adult patient (≥ 18 years) * patient hospitalized * patient receives systemic antibiotic treatment * patient contractually capable * patient able to follow study procedures * informed consent of patient exclusion criteria: * allergy against yeast and/or perenterol® forte und/oder placebos containing saccharomyces cerevisiae hansen cbs 5926, lactose-monohydrate, magnesium stearate, gelatine, sodium dodecyl sulfate, titan dioxide, microcrystalline cellulose. * central venous catheter * immunosuppression * diarrhoea and/or chronic diarrhoea * regular intake of perenterol®, perenterol® forte oder yomogi® in the last seven days before the start of the study * systemic antimycotic treatment * systemic antibiotic treatment within the last 6 weeks * no protection against conception, pregnancy, or lactation * simultaneous participation in other clinical trials

Keywords: antibiotic associated diarrhoea saccharomyces boulardii antibiotic-associated diarrhoea (aad) clostridium difficile-associated-diarrhoea (cdad)
biomaterials and mesenchymal stem/stromal cells in the treatment of knee articular surface lesions

Conditions: Knee Injuries; Cartilage Injury; Osteochondral Defect

Summary: the goal of this observational study is to evaluate the combined single-step approach with biomaterials and mesenchymal stem/stromal cells in the treatment of knee articular surface lesions. the clinical analysis of the treatment outcomes, regarding postoperative improvements and safety, is going to be accompanied with laboratory analysis of the intraoperatively applied cellular products. the main hypothesis are: (1) such combined single-step procedure significantly improves patients' functioning and quality of life; (2) this therapeutic approach is safe; (3) cellular parameters of the applied filtered bone marrow aspirate (fbma) impact treatment outcomes, among other potential predictors. researchers will compare subjective (questionnaire) and objective (clinical examination) status of patients before and after the operation, record any potential complications and perform regression analysis to assess the influence of potential predictors on postoperative improvements.


Eligibility criteria:
inclusion criteria: * informed consent * patients treated with combined single-step procedure (scaffold and fbma) for knee articular surface lesions, between january 2013 and december 2020 * symptomatic knee articular surface lesions (international cartilage repair society (icrs) grades 3-4, size ≥ 1.5 cm2) unresponsive to conservative treatment, * only mild concomitant osteoarthritis (kellgren-lawrence grades 1-2) exclusion criteria: * patients that refuse to participate in the study * non responders to the invitation to answer proms at the follow-up * associated medical conditions (inflammatory, metabolic, neoplastic, etc.) that could directly handicap the musculoskeletal system or indirectly impact the quality of life

Keywords: biomaterials mesenchymal stem/stromal cells bone marrow aspirate cartilage osteochondral lesion knee
brief admission by self-referral for individuals with self-harm: effects on compulsory care

Conditions: Self-injury; Suicide; Suicide, Attempted; Self-harm; Borderline Personality Disorder; Emergency Psychiatric; Hospitalizations Psychiatric

Summary: brief admission by self-referral (ba) is a standardized treatment model, providing patient-controlled and person-centered care. it was developed to reduce self-harm and compulsory care by promoting autonomy. randomized clinical trials have not yielded significant between group differences with respect to inpatient care, including compulsory care. the major difficulty in evaluating ba is preventing the control group from cross-contamination, as in the implementation process of ba, all physicians, all inpatient and outpatient staff as well as managers need to be informed and undergo basic education regarding the intervention. as ba addresses a prevalent and frustrating issue in psychiatric health care, there is considerable risk that the approach leaks to the control group, reducing the possibility to detect between-group differences. in the current study this will be addressed through a register-based approach, comparing similar clinics, implementing ba at different timepoints over time. individuals with traits of borderline personality disorder will be included and comparisons will be made with respect to compulsory care, voluntary inpatient care and mortality.


Eligibility criteria:
inclusion criteria: * living in the uptake area of lund, linköping, helsingborg or norrköping * age 18-65 years at the time of inclusion * admitted to hospital either diagnosed with icd-10 diagnosis bpd f60.3, or admitted at least twice with intentional self-harm x60-83 in combination with one of more of the following diagnoses adhd (f90.0-f90.x), bipolar disorder type 2, (f31.8w, f318a-f, f31.0, f31.8-9, f31.8w) or autism, atypical autism, aspergers syndrome (f84.0, f84.1, f84.5) or mild intellectual disability (f70.0-f70.9). exclusion criteria: * not fulfilling inclusion criteria

Keywords: brief admission by self-referral self-harm traits of borderline personality disorder compulsory care
effects of pilates exercises on core stability after recovery from covid -19

Conditions: Covid19; Pilates, Core Stability

Summary: this study will be conducted in the department of physical therapy, college of applied medical sciences,jazan university, to effects of pilates exercises on core stability after recovery from covid - 19

145 male and female students who had infected with covid 19 with age 19 to 26 years old, will be recruited from the college of applied medical sciences, jazan university. subjects will be randomly assigned to a pilates and home exercises (pah) group or a control group who will perform only home exercises (coh) four core endurance tests will be performed to assess the core stability pilates exercise program will be composed of pilates mat exercise program for a period of 12 weeks and three sessions every week. each session took one hour. every session started with 10 minutes of simple stretching movements to warm-up followed by the main part of the exercise plan for 40 min, followed by 10 minutes, some cool-down stretching. when the 12-week study period will over, the core stability will be assessed by the endurance tests and prokin system for balance

Eligibility criteria:
inclusion criteria: 1. persons who had mild to moderate covid- 19 illness. 2. asymptomatic period of at least seven days (without chest pain, breathlessness). 3. no musculoskeletal damage. 4. no pregnancy. 5. no visually identified asymmetries in the spinal trunk and lower limbs. 6. none of the subjects has a history of balance training 7. subjects will not have any diseases of the central nervous system. 8. subjects with body mass index (bmi)\<25 kg/m2. exclusion criteria: 1. persons who had more severe covid 19 illnesses and were hospitalized. 2. persons who had during their illness chest pain breathlessness, palpitation, symptoms, and signs of heart failure. 9. subjects with cardiopulmonary disorders. 3. a history of previous back or abdominal surgery/injury 4. evidence of a systemic or musculoskeletal disease within the past six months -
effects of autologous blood injection versus platelet rich plasma on chronic plantar fasciitis

Conditions: Plantar Fascitis

Summary: to explore effects of autologous blood injection versus platelet rich plasma injection for treatment of chronic plantar fasciitis

after clinical diagnosis of patients with plantar fasciitis. patients were divided into two groups. group a (prp injection group) and group b (abi group) were randomized according to web based block group randomization. patients were evaluated prior to injection in terms of health related quality of life scores related to foot and ankle diseases (aofas and fadi) and vas. after injection at 1st, 3rd and 6th months hrqol were compared between groups. intra group evaluation for hrqol were performed at f/up visits. independent t test and repeated measure anova test used for statistical analysis

Eligibility criteria:
inclusion criteria: 1. participants who were diagnosed with chronic plantar fasciitis 2. nonresponded to o conservative treatment (stretching exercises, nonsteroidal anti-inflammatory drugs, and heel pads) for at least 6 weeks 3. patient should be able to understand the informed consent about type of treatment and blindness and randomization 4. visual analog scale pain higher than 5 (on a 10-point visual analog scale) exclusion criteria: 1. previous history of any type of local injection treatment for heel pain 2. history of surgery for heel pain, foot and ankle disorders, fractures 3. associated pathology involving the lower limb such as * tarsal tunnel syndrome * effusion of the ankle indicating an intra-articular disease * peroneal/achilles/tibialis tendons pathology * any obvious deformity of foot and ankle, 4. patients with systemic disorder like diabetes mellitus, ankylosing spondylitis rheumatoid arthritis, hematological disease, or gout 5. pregnancy 6. use of antiocoagulation -

Keywords: heel pain, platelet rich plasm, autologous blood injection
changes in adiponectin and cardiovascular disease risk factors in overweight patients

Conditions: Exercise; Cardiac Myosins; Patients

Summary: this study aimed to determine if eight-weeks of exercise-based cardiac rehabilitation could improve adiponectin and cardiovascular disease risk factors in overweight coronary heart disease patients. patients were included in the study if: they were approved to do so following a physical, physiological and psychological test; did not take part in regular physical activity; had stable heart failure for at least 3 months. exclusion criteria included: a history of surgery within the preceding 4 months; had an unstable angina, acute phase of myocardial infarction, and/or unstable arrhythmia; had obstructive cardiomyopathy, exercise-induced ischemia or arrhythmias, uncontrolled arrhythmias, resting blood pressure more than 200/120 millimeters mercury, aortic stenosis, and/or peripheral artery disease; exercise limitations due to neuromuscular and/or musculoskeletal disease; had any health problems that prevented maximum effort on the treadmill test. target population included of all patients with a history of myocardial infarction and diagnosis of congestive heart failure who were referred to isfahan cardiovascular research centre. 60overweight coronary heart disease patients were randomly assigned to either an eight-week, three times weekly exercise group (n=30), or a non-exercising control group (n=30). exercise sessions took place at 60-85% of maximal heart rate, lasted 45-60 minutes and included a 10-minute warm-up, 40 minutes of aerobic exercises, consisting of stationary cycling, walking and/or jogging, flexibility, balance exercises, and weight-bearing activity and a 10-minute cool-down.


Eligibility criteria:
inclusion criteria: * they were approved to do so following a physical, physiological and psychological test; resided and worked in the city of isfahan; did not take part in regular physical activity; had stable heart failure for at least 3 months. exclusion criteria: * a history of surgery within the preceding 4 months * had an unstable angina, acute phase of myocardial infarction (mi), and/or unstable arrhythmia * had obstructive cardiomyopathy, exercise-induced ischemia or arrhythmias, uncontrolled arrhythmias, resting blood pressure more than 200/120 millimeters mercury (mmhg), aortic stenosis, and/or peripheral artery disease * exercise limitations due to neuromuscular and/or musculoskeletal disease, such as any type of orthopedic, low back pain, bone fracture of less than 6 months * uncontrolled systemic disease, such as dm; were 75 years or older * had any health problems that prevented maximum effort on the treadmill test * unable to answer the screening questionnaires assessing depression and anxiety.