Kornimate/medical-research-clean huggingface dataset:
a study to test the efficacy and safety of the beta-3 agonist mirabegron (ym178) in patients with symptoms of overactive bladder

Conditions: Urinary Bladder, Overactive

Summary: the study is intended to test efficacy, safety and tolerability of two doses of once daily (qd) mirabegron against placebo to treat patients with symptoms of overactive bladder.


Eligibility criteria:
inclusion criteria: * patient is willing and able to complete the micturition diary and questionnaires correctly * patient has symptoms of overactive bladder (oab) for ≥ 3 months * patient must experience frequency of micturition on average ≥ 8 times per 24-hour period during the 3-day micturition diary period * patient must experience at least 3 episodes of urgency (grade 3 or 4) with or without incontinence during the 3-day micturition diary period exclusion criteria: * patient is breastfeeding, pregnant, intends to become pregnant during the study, or of childbearing potential, sexually active and not practicing a highly reliable method of birth control * patient has significant stress incontinence or mixed stress/urge incontinence where stress is the predominant factor * patient is using medications intended to treat oab * patient has an indwelling catheter or practices intermittent self-catheterization * patient has diabetic neuropathy * patient has evidence of urinary tract infection, chronic inflammation such as interstitial cystitis, bladder stones, previous pelvic radiation therapy or previous or current malignant disease of the pelvic organs * patient receives non-drug treatment including electro-stimulation therapy * patient has severe hypertension * patient has participated in a clinical study within 30 days, or had participated in any previous study with mirabegron * patient had an average total daily urine volume \> 3000 ml as recorded in the 3-day micturition diary period * patient has serum creatinine of \>150 μmol/l, or aspartate aminotransferase (ast) or alanine aminotransferase (alt) \> 2x upper limit of normal range (uln), or gamma-glutamyl transpeptidase (γ-gt) \> 3x uln * patient has a clinically significant abnormal electrocardiogram (ecg)

Keywords: urgency ym178 urinary incontinence mirabegron micturition frequency urinary urgency incontinence overactive bladder
study of welltang- a cell phone-based diabetes management application's effect on blood glucose control

Conditions: Diabetes Mellitus

Summary: the aim was to assess the impact of a cell phone-based diabetes management application (welltang) on hba1c, blood glucose, lipids, physical activity, weight, and blood pressure during 3 months. and hypoglycemic events, the satisfaction of the patients with boyibang, their diabetes knowledge and self-care behaviors were also evaluated.

at baseline, all patients completed the diabetes self- care behavior questionnaire and a diabetes knowledge survey. health, medical and demographic history, height and weight, waist and hip circumferences, and blood pressure were recorded. hba1c and low-density lipoprotein cholesterol (ldl-c) level were tested. all of these data were measured 3 months later at the conclusion of the study intervention.

Eligibility criteria:
inclusion criteria: * all diabetes, aged more than 18 years old. no limit for hba1c was defined exclusion criteria: * patients have any severe complications such as end phase of diabetic nephropathy or proliferative retinopathy. patients who cannot use smart phone.
effect of the pelvic loin musculature training on the dynamic hip stabilization

Conditions: Exercise Addiction

Summary: introduction: the stability of the pelvis is of great importance in body balance as a whole, can be improved by training the pelvic muscles fillet (mlp), which is characterized by low intensity isometric synchronous and the deep muscles of the trunk. this study aims to determine the effect of a stability program target, with the training of the mlp region on pelvic stability.

this study aims to determine the effect of a stability program target, with the training of the mlp region on pelvic stability. materials and methods: we recruited 20 volunteers of both sexes were randomly divided into control group (cg) and training group (tg). the evaluations were performed before and after training the mlp. the training was held four isometrics series with a time of 30 seconds with 30 seconds rest in between reps during 10 sessions distributed twice weekly.

Eligibility criteria:
inclusion criteria: * considered individuals of both sexes, aged 18 and 35 * absence of low back pain * lack of musculoskeletal dysfunction in the lower limbs * have never participated in any stabilization training program of the mlp region * agree to the terms informed consent form (icf) and the sign voluntarily. exclusion criteria: * the study of abandonment by a participant * the disagreement with the terms of ic and its not signing * the volunteer does not understand the implementation of dynamic hip stabilization test * present cramps or pain during the test and / or training * historical column in injury, knee and / or ankle.

Keywords: physiotherapeutic techniques pelvis muscle strength
the study of the early administration of alendronate on prevention of bone loss after hip fracture.

Conditions: Osteoporosis

Summary: to determine whether administration of alendronate early is more effective than late in the prevention of osteoporosis following a hip fracture


Eligibility criteria:
inclusion criteria: male and female aged \> 55 low trauma hip fracture up to 90 days be willing to submit to periodic bone mineral density radiographic studies of the spine \& 24 hr urine collection written informed consent - exclusion criteria: * disorders known to affect bone metabolism not taking bisphosphonates within last 6 months drugs known to interfere with calcium metabolism within the lats 6 months prior to hip fracture serum calcium\> 2.65 mmol/l treatment with any investigational drug within the last 30 days
lactate use as triage tool in sepsis : veinous, capillary or arterial?

Conditions: Sepsis

Summary: severe sepsis and septic shocks are increasingly codified. a biomarker as lactate is very interesting to detect those situations. usually, lactate used is arterial but results are often too slow to obtain if we want to respect surviving sepsis campaign guidelines. some analyzers (ekf diagnostics lactate scout\*) can give results in 15 seconds. we hypothesized that capillary lactate, easy to sample, tested with this analyzer may detect earlier those infections states and we want to find the most accurate site to detect severe sepsis (capillary, venous or arterial sample).

actually, patients presenting a sepsis with arterial lactate\> 2 mmol.l-1 must be considered as criticals, and if lactate\> 4 mmol.l-1 as septic shock. however, results are usually slow to obtain, especially if we want to respect the surving sepsis campaign, which preconize antibiotic as soon as possible (first hour). in admission room, arterial sample can't be easily done and usual results need more than 30 minutes. on the contrary, using analyzers like "ekf diagnostics lactate scout\*" can give results faster with capillary blood (15 seconds). we will compare this results with both veinous and arterial lactate. * for primary outcome, we will determine the most accurate value of capillary or veinous lactate that may be able to detect critical patient suspected of infection. * for secondary outcomes, we will determine if quick capillary lactate test may replace arterial lactate in this indication and be able to predict mortality.

Eligibility criteria:
inclusion criteria: * age \>18 years * s.i.r.s : 2 or more criteria (fever \> 38.3°c or hypothermia (core temperature \ 90.min-1, tachypnea, altered mental status) * suspected infection exclusion criteria: * arterial sample by laboratory reference method no available

Keywords: lactate sepsis capillary lactate venous lactate quick test
effects of wound infiltration with ketamine versus dexmedetomidine added to bupivacaine on cytokines

Conditions: Endometrial Adenocarcinoma

Summary: this study aims to compare the effects of local wound infiltration with ketamine versus dexmedetomidine when added to bupivacaine on inflammatory cytokine response after total abdominal hysterectomy.


Eligibility criteria:
inclusion criteria: * asa i-ii patients * age range (18-60) years, * weight (50- 90) kg exclusion criteria: * allergy to study drugs * significant cardiac disease * respiratory disease * renal disease * hepatic disease
preliminary study for selective detection of the cd8+ myelin specific t cell in the blood of multiple sclerosis patients

Conditions: Multiple Sclerosis

Summary: most experts in the field consider multiple sclerosis as the main auto immune disease of the central nervous system. in spite of many works, the data in the literature concerning the antigens targeted by the cd8+ t-cell response are still contradictory and insufficient.

30 patients distributed in 3 groups of 10 patients with specific inclusion criteria will participate in this trial: * 10 ms patients in early disease onset, * 10 ms patients under natalizumab treatment * and control group of 10 patients with other neurological diseases. the aim of this clinical trial is to detect the cd8+ myelin specific t-cells in the blood of multiple sclerosis patients.

Eligibility criteria:
inclusion criteria: group 1: hla-a2 patients whose multiple sclerosis has just been diagnosed * 18 year old and older patients, * hla-a2 patients with multiple sclerosis or clinically isolated syndrome at high risk of being affected by multiple sclerosis (criteria of spatial scattering according to the 2010 or 2005 mcdonald's criteria) * patients without treatment or treated with immunomodulating therapy * patients affiliated to health insurance coverage * information and comprehensive agreement signed by the patient and the investigator group 2: hla-a2 patients hospitalized in the neurology department who are not affected with a neuroimmunological disorder * 18 year old and older patients, * hla-a2 patients hospitalized in the neurology department * patient not affected by multiple sclerosis or a related inflammatory disorder * affiliated or profitable subject of a national insurance scheme * patients affiliated to health insurance coverage * information and comprehensive agreement signed by the patient and the investigator group 3: hla-a2 multiple sclerosis patients treated by natalizumab therapy * 18 year old and older patients, * hla-a2 patients with relapsing remitting (rr) ms fulfilling mcdonald 2005 or 2010 multiple sclerosis diagnostic criteria * patients treated by natalizumab therapy for at least 3 months * patients affiliated to health insurance coverage * information and comprehensive agreement signed by the patient and the investigator exclusion criteria: group 1 and 3: * patients undergoing immunosuppressive therapy at present or in the past except natalizumab * pregnant women group 2: * patients undergoing immunosuppressive therapy at present or in the past * patients affected by multiple sclerosis or a related disorder * pregnant women

Keywords: multiple sclerosis cd8+ t-cells class i major histocompatibility complex (mhc) pentamers
effect of plasma derived exosomes on cutaneous wound healing

Conditions: Ulcer

Summary: this study is an open prospective clinical trial. the objective is to evaluate the effect of autologous exosomes rich plasma on cutaneous wound healing. the participants are patients with intractable cutaneous ulcers (e.g. rheumatic disease, peripheral arterial disease, chronic venous insufficiency, decubitus or burns). the participants will be treated autologous exosomes rich plasma every day for 28 days. the cutaneous wound healing will be evaluated by the length, width and depth of the wound.

exosomes are small vesicles 0.03-0.1 μm in size, which are shed from most cell types into the extracellular space via intracellular endocytosis. they are found abundantly in body fluids such as blood. they consist of lipid bilayer so that their structure is stable. they can be preserved for 2 weeks at 4℃. they contain proteins, lipids and nucleic acids including coding or non-coding rna. resent studies have revealed that exosomes have an important role in cell-to-cell communication. the investigators found that serum exosome levels were significantly decreased in scleroderma patients with vascular involvements such as cutaneous ulcers and/or pitting scars compared to in normal subjects. the investigators also elucidated that serum-derived exosomes accelerated cutaneous wound healing in balb/c mice. exosome supplementation to cutaneous ulcers seems to have significant therapeutic value. the objective of present study is to evaluate the effect of exosomes derived from plasma on intractable cutaneous ulcers (e.g. rheumatic disease, peripheral arterial disease, chronic venous insufficiency, decubitus or burns). autologous exosomes are obtained from the participants' own plasma. the duration of study is 28days. the cutaneous wound healing will be evaluated at day1, day2, day7, day14, day 21 day 28.

Eligibility criteria:
inclusion criteria: patients with intractable cutaneous ulcers (e.g. rheumatic disease, peripheral arterial disease, chronic venous insufficiency, decubitus or burns) exclusion criteria: 1. patients who have ulcers with bone involvement. 2. patients who have ulcers with a history or suspected neoplasia. 3. patients who are in chemotherapy or radiation therapy on the skin ulcers. 4. patients with marked immunodeficiency (i.e., patients with severe liver failure, heart failure, hematologic failure or endocrine failure) 5. patients who have clinical signs of malnutrition or serum albumin \<2 mg / dl. 6. patients who have severe infection. 7. patients who are pregnant or breastfeeding. 8. patients who are participating in another study. 9. patients who are judged inappropriate for this trial by their attending physician.
clinical evaluation of direct composite veneer restorations

Conditions: Molar Incisor Hypomineralization

Summary: the objective of this research was to evaluate the clinical success of direct composite veneer restorations performed in permanent incisors affected by molar-incisor hypomineralization.


Eligibility criteria:
inclusion criteria: * cooperative children diagnosed with mih according to european academy of paediatric dentistry (eapd) criteria * maxillary anterior teeth with mih-caused coloring and opacity areas * fully erupted anterior teeth exclusion criteria: * patients and parents of patients who accept to participate. * patients who are not in cooperation with the procedure.
study of responsiveness of seven functional tasks in patients with poststroke upper limb spasticity with botulinum toxin type a treatment

Conditions: Stroke; Muscle Spasticity

Summary: this study evaluates the responsiveness of 7 functional tasks to botulinum toxin type a treatment in poststroke patients with spasticity of the upper-limb flexors


Eligibility criteria:
inclusion criteria: * medically stable poststroke with focal unilateral upper-limb spasticity exclusion criteria: * stroke within 6 months of the study enrollment visit * previous or current botulinum toxin therapy of any type in the study limb
prednisolone urinary excretion kinetics

Conditions: Articular Cartilage Disorder of Knee

Summary: the urinary elimination kinetics of glucocorticoids after intra-articular injection is very poorly documented. it is estimated that glucocorticoids may be present in the urine up to 6 weeks after intra-articular injection. however, this is not supported by any scientific literature. despite this lack of evidence, in doping control practice, any presence of glucocorticoids in urine is accepted when the athlete provides evidence of an intra-articular injection that took place less than 6 weeks prior to the doping control. many doping cases are open to challenge because they are based solely on measurements of prednisolone concentrations and its blood esterase product, prednisone. in order to demonstrate the use of prednisolone for doping purposes (systemic and not intra-articular use), it is therefore necessary to know the urinary elimination kinetics of prednisolone and prednisone, as well as the evolution of the concentration ratio between these 2 molecules.


Eligibility criteria:
inclusion criteria: * - male or female * 18-65 years old * requiring intra-articular injection of prednisolone as part of routine care * naive to any corticosteroid administration * requiring a blood biology test as part of routine care and before the infiltration procedure * for women of childbearing age, negative urine pregnancy test at inclusion * affiliated to a social health insurance plan * able to understand the protocol and give free, informed and written consent exclusion criteria: * na

Keywords: doping prednisolone pharmacokinetics pharmacogenetics
presence of enamel fluorosis in libyan children

Conditions: Dental Fluorosis

Summary: fluorosis is caused by hypomineralization in the enamel due to increased fluoride ingestion during early childhood (cawson.1, wong et al. 2, and sudhir 3). a considerable amount of evidence has been reported over the years, which has shown that presence of fluoride ions at up to one part per million in public water supply has reduced the prevalence of teeth decayed with minimal chance of dental fluorosis. the who recognized these facts by its resolution in 1969 4 and 1975 5, which stated that water fluoridation, where applicable, should be the cornerstone of any national policy of caries prevention

the optimal concentration is defined as that which gives maximal protection against dental caries, with minimal clinically observable dental fluorosis (dunning 7). this level is determined according to the climate and the resultant drinking habits (newborn 6). cawson 1 stated that mottling of enamel is the most frequently seen and most reliable sign of excessive quantities of fluoride in the drinking water. dean 8 concluded that a fluoride level of above 1ppm does not significantly reduce caries beyond the optimal effect of 1ppm. different classifications have been introduce to score dental fluorosis. (dean 9, al -alousi 10, thylstrup \& fejerskov 11, (fejerskov, 12). and the dde index by fdi 1982). aira sabokseir 13, concluded, fluorosis indices, if used alone, could result in misdiagnosis of dental fluorosis and information about adverse health-related conditions linked to ddes (developmental defects of enamel) at specific positions on teeth could help to differentiate between genuine fluorosis and fluorosis-resembling defects.various figures for mouth prevalence of enamel fluorosis have been reported by different investigators. 39.2% by al-alousi 10, for welsh children, 32% by akpata 14 for nigerian children. using the dde index of the fdi (1982), al alousi 10 defective enamel of 48.9% in children from south wales. in england,tabari 15 found the prevalence of fluorosis was 54% in the fluoridated area and 23% in the fluoride-deficient area. in iran the prevalence of fluorosis was 61% (azami-aghdash et al., 16).

Eligibility criteria:
inclusion criteria: * libyan children born and lived in the same area. 2. limited to incisors only. exclusion criteria: * non- libyan children. 2. children who born or lived outside the study areas. 3. incisors with class ii fracture (ellis type 1970) or crowned

Keywords: fluoride mottling libya fluorosis
st2, a novel biomarker for cardiac remodeling in adults with congenital heart disease

Conditions: Congenital Heart Disease

Summary: the remarkable improvement in survival of children with congenital disease has led to a continuously growing number of adults with congenital heart disease in the developed world. many of these patients had had cardiac surgery at early age, the may live for many years with pressure overload, volume overload, systolic or diastolic dysfunction, cyanosis or any combination of the above. these past and ongoing cardiac insults often result in significant cardiac remodeling. a biomarker for fibrosis and remodeling may have enormous clinical and prognostic value for these patients. serum biomarkers are now integrated in many fields in medicine. in cardiology, a number of biomarkers are used. in the last decade, our group has focused on the natriuretic peptides as markers for heart disease in infants and children. this resulted in many studies and more than 25 publications in the medical literature. we believe that the newly discovered cardiac marker, st2, will emerge as an important addition to cardiac evaluation in the coming years.the aim of this study is to measure st2 levels in patients with congenital right heart disease and correlate st2 levels to clinical status, imaging and prognosis.


Eligibility criteria:
inclusion criteria: * adults (age\>18 y) * congenital heart disease exclusion criteria: * additional lung diseases, renal disease or inflammatory disease. * patients who underwent therapeutic intervention between the mri and the st2 - measurements. * pregnant women
health economics evaluation of the management of severe postpartum hemorrhage: comparison of recombinant activated factor vii strategy to the reference strategy

Conditions: Health Care Cost; Post Partum Haemorrhage

Summary: the main objective of this project is to assess the average cost of the treatment of bleeding postpartum with recombinant activated factor vii (novoseven®) and compare it to the reference strategy. costs related to medicine novoseven® can generate surplus, but it also avoids in some cases very costly invasive procedures. it will be interesting to compare the average cost of the complete strategies supported.


Eligibility criteria:
inclusion criteria: * severe haemorrhage is defined by the following criteria: blood loss greater than 1500 ml graduated measured in the bag and / or hemodynamically unstable and / or requiring transfusion of packed red blood cells (3); * sulprostone (nalador®) ineffective; * age over 18 years; * the term is more than 27 sa (child's viability); * without anthropomorphic limit; * the outcome of the pregnancy is normal or pathological; * informed consent "emergency procedure" is signed by the husband or family. exclusion criteria: * minors, majors in guardianship, with a personal history of venous or arterial thrombosis may cons-indicate treatment with rfviia or refuses to sign the consent
effect of fes of back muscles on spinal posture and gait in hemiplegia

Conditions: Stroke

Summary: hemiplegic patient have unbalanced posture because paralysis leads to muscle atrophy, which then causes an unbalanced alignment in the structure of spinal joints. evaluation and therapy of postural alignment are important as early predictable factors in the overall daily function of stroke patients

to evaluate whether the application of fes of the back muscles in hemiplegic affect spinal posture and/or gait

Eligibility criteria:
inclusion criteria: * 20 children with c.p. hemiplegia * moving and performing daily activities independently * no problems in terms of verbal communication * no physical and cognitive restrictions. exclusion criteria: * having cognitive impairment as tested by the mini-mental state examination (with scores \< 24) * uncontrolled hypertension (systolic blood pressure \> 160 mmhg) * joint replacement * incontinence