Kornimate/medical-research-clean huggingface dataset:
testing of a tool to elicit patient preferences for cts

Conditions: Carpal Tunnel; Carpal Tunnel Syndrome; Carpal Tunnel Syndrome Left; Carpal Tunnel Syndrome Right; Carpal Tunnel Syndrome Bilateral

Summary: this study will complete a randomized controlled trial to quantitatively measure patient decisional conflict (decisional conflict scale) in 150 patients treated for cts with the tool compared to 150 patients treated with standard care. the investigators hypothesize patients treated for cts will have lower decisional conflict with the tool.

the investigators will measure decisional conflict in 150 new patients being evaluated for cts with the tool compared to 150 patients being evaluated for cts with standard care. those patients randomized to receiving the tool will use it to identify their preferences for certain attributes of care. patients will then be presented with their preference data and the surgeon will have a discussion with the patient regarding cts. surgeons will have their standard discussion with the patients randomized to the standard care group (no tool). the tool will be operationalized on a health insurance portability and accountability act compliant data platform, such as qualtrics, and no identifiable data will be collected. de-identified data will be shared from study cites with our team at stanford. this data will be backed up on a computer encrypted by stanford.

Eligibility criteria:
inclusion criteria: * new patient * english fluency and literacy * able to take informed consent * clinical diagnosis of carpal tunnel syndrome exclusion criteria: * prior diagnostic testing for carpal tunnel (nerve test, ultrasound) * prior carpal tunnel release * diagnosis of c5/6 radiculopathy (double crush) * peripheral neuropathy (ex: diabetic) * worker compensation/emg required * symptoms of cubital tunnel syndrome
personal resilience empowerment program study

Conditions: Lung Cancer; Cholangiocarcinoma; Pancreatic Cancer; Liver Cancer

Summary: the personal resilience empowerment program (prep) at hackensack meridian integrative health \& medicine was designed in legacy meridian to assist all selected patients with upcoming hospitalization. for the "personal resilience empowerment program (prep) in the perioperative setting of surgically treated cancer patients", hereafter "the project or prep", the hackensack meridian integrative health \& medicine is designing a new pilot program to focus on the needs of oncology patients. all patients diagnosed with cancer that will undergo a scheduled surgical (hepato-biliary, and thoracic) procedure in hackensack meridian health and specifically in the jersey shore university medical center, will be eligible to participate (for more details please see eligibility criteria, section 4). overall, this pilot project will include 5 coaching sessions and an introductory session/visit that will take place on the physician's office. the initial physician visit will focus on patient eligibility, introduction to the project, informed consent and a pre-intervention survey and will be conducted by the principal investigator or one of the sub-investigators listed above. the following 5 sessions will be conducted by one of the integrative health coaches/registered nurses (for details please see section 5). a post-intervention survey will be completed during the final session and repeated at one month, and at 3 months from the final session. the goal of this project is to investigate whether using the prep as an intervention in patients diagnosed with cancer would result in improving various metrics including improvements to resilience, sleep, activity, purpose, nutrition, empowerment to manage one's own health and well-being, decrease in pain medication use and more rapid return to previous functional status according to eastern cooperative oncology group (ecog).


Eligibility criteria:
inclusion criteria: * patients diagnosed with cancer of the thoracic (lung), hepatobiliary system (cholangiocarcinoma, pancreatic, liver) that will undergo a scheduled surgical procedure * able to understand and sign the informed consent form * willingness to participate in the study and comply with protocol requirements exclusion criteria: * unable to provide consent * unable to participate at the discretion of the pi based on the ecog survey (if ecog \>1). see section 5 and appendix 1 for details. * non- english speaking patients . * opioid use for non-malignant pain for greater than 7 days 6 terminal or stage 4 cancer.

Keywords: integrative medicine cancer patients
active external rewarming from accidental hypothermia - a dose-response pilot study

Conditions: Accidental Hypothermia

Summary: the aim of this pilot study is to evaluate if there is a dose-response relationship between the use of active external rewarming devices and core temperature rewarming rate from simulated accidental hypothermia. volunteer research participants will be cooled in a field laboratory, and they will recieve medications to inhibit shivering, enabeling a drop in core temperature. subsequently, they will be treated with either one, two or four heating blankets, and analyses will be performed to investigate whether we are able to find a difference between the three groups.

the aim of this pilot study is to evaluate if there is a dose-response relationship between the use of active external rewarming devices and core temperature rewarming rate from simulated accidental hypothermia. volunteer research participants will be cooled in a field laboratory, and they will recieve medications to inhibit shivering, enabeling a drop in core temperature. all participants will be monitored extensively using a trans-nasal esophageal temperature probe, ecg, spo2, blood pressure, skin temperature and with subjective scores. after the cooling phase, the participants will be treated with either one, two or four heating blankets assigned in a randomized order, and analyses will be performed to investigate whether we are able to find a difference between the three groups.

Eligibility criteria:
inclusion criteria: * healthy exclusion criteria: * normal bmi * smoking

Keywords: hypothermia active external rewarming
exploratory propofol dose finding study in neonates

Conditions: Adverse Reaction to Drug; Neonatal Disorder

Summary: the aim of the study is to explore the optimal propofol dose in neonates receiving a single intravenous propofol bolus for endotracheal intubation during (semi-)elective insure (intubation-surfactant-extubation) procedure (preterm neonates) and (semi-)elective non-insure procedures (term-preterm neonates).

the aim of the study is to evaluate the pharmacokinetics and pharmacodynamics of propofol (short acting anesthetic) in 50 neonates to whom the drug is administered as a intravenous bolus. this is part of routine clinical care in patients receiving (semi-) elective intubation. it's the aim to explore the most effective iv propofol dose for a successful insure (intubation, surfactant, extubation) procedure and for successful (semi-) elective intubation in non-insure procedures. we hereby aim to define the most optimal dose regimen for propofol in neonates. intubation condition score was assessed retrospectively by the intubating physician.

Eligibility criteria:
inclusion criteria: * neonates admitted to the neonatal intensive care unit who need short procedural sedation for (semi-) elective intubation will be considered for inclusion, after informed written consent of the parents. * patients can be included if they are hemodynamically stable and did not receive sedative or analgesic agents during the previous 24 hours. exclusion criteria: * known propofol intolerance

Keywords: neonatology intratracheal intubation propofol
lipid transport disorder italian genetic record (lipigen)

Conditions: Familial Hypercholesterolemia; Genetic Disorder

Summary: lipigen is an observational study involving italian physicians and researchers in the field of diseases related to blood lipid levels. this study aims to improve the diagnosis and treatment of people with familial dyslipidaemias, including very common conditions such as familial hypercholesterolaemia (fh) and less common ones such as familial chylomicronidaemic syndrome (fcs). what does the study do? it collects information on italian patients with familial hypercholesterolaemia (fh), following them in their normal clinical examination without adding extra procedures. it uses the data collected to further our understanding of diseases such as familial hypercholesterolaemia, examining how it is diagnosed clinically and by genetic testing, and evaluating the effectiveness of different treatments. it seeks to identify the genetic mutations that cause familial hypercholesterolaemia and other dyslipidaemias, helping to choose the most effective treatments. it evaluates the impact of long-term treatments and patient adherence to medication, as well as monitoring the incidence of cardiovascular events and other important outcomes. who can participate? the study is aimed at people of all ages, from children to adults, with familial hypercholesterolaemia or other genetic dyslipidaemia. more than 50 centres throughout italy are involved, making the study accessible to many. what does participation entail? participants will continue with their normal clinical practice. data such as family history, personal clinical findings and genetic information will be collected, without additional procedures. for some, further evaluations, such as ultrasounds, may be required to better study their condition. the lipigen study not only helps to better understand diseases related to high cholesterol but also aims to improve patients\&#39; lives through more precise diagnosis and personalised treatments.


Eligibility criteria:
inclusion criteria: * molecular or clinical diagnosis of genetic dyslipidemia * informed consent signed exclusion criteria: * none

Keywords: lipigen familial hypercholesterelomia genetic dyslipidemia
using retinal photograph based ai to predict incident coronary heart disease

Conditions: Coronary Heart Disease (CHD)

Summary: to determine whether an integrated retinal ai decision support can improve predictive accuracy of coronary heart disease (chd), the investigators are conducting a randomized controlled study of ai guided prediction of chd compared to clinical prediction by physicians (e.g., usingpces), both using clinical intuition as baseline.

this is a randomized controlled trial (rct) evaluating the effectiveness of an ai-based decision support tool in chd risk prediction and decision making by physicians. prospective cohort study participant cases will be randomly assigned to either guideline group (e.g., pces) or ai group after baseline assessment (clinical intuition): there are three settings: (1) clinical intuition (baseline assessment) physicians' make decision about prevention strategy initiation (e.g., statin initiation) without any external assistance. assessment relies solely on the physician's clinical judgment and experience. (2) guideline-based group (guideline group) physicians use a pce table to calculate the 10 year ascvd risk. this approach aligns with current clinical guidelines to assist in decision-making. (3) ai-assisted group (ai group) physicians receive chd probability estimates from an ai model based on retinal photographs. the ai tool provides individualized obstructive chd probabilities, leveraging retinal biomarkers associated with cardiovascular risk. primary objective to evaluate whether ai-guided decision support could improves diagnostic accuracy of chd to a greater extent than standard clinical assessments, both compared to clinical intuition. the accuracy could be assessed by the extent of prevention initiation (e.g., prescribing statins) corresponding with actual chd outcomes observed. secondary objective to assess whether ai-guided decision support reduces the time required to complete chd assessments and decision making. participants, readers and randomization: participants: participants in prospective cohort studies, with 10-year follow up. readers: physicians performing evaluations of chd probability and make primary prevention recommendations. randomization: participants will be randomized into one of the groups (pces or ai) after clinical assessment at baseline using block randomization to ensure balanced group sizes.

Eligibility criteria:
inclusion criteria: * individuals without uncontrolled vascular risk factors * age range: 40-75 years old * can accept and cooperate with the examination and potential follow-up work after being selected for clinical trials exclusion criteria: * severe lung disease and cancer or surgery patients * statin user or pre-existing cardiovascular disease * individuals with severe liver and kidney dysfunction and electrolyte imbalance
effect of low-level laser therapy during maxillary molar distalization using a skeletally anchored appliance

Conditions: Class II Division 1 Malocclusion

Summary: study will be directed to evaluate the effect of low-level laser therapy during maxillary molar distalization using a skeletally anchored appliance

effect of low-level laser therapy during maxillary molar distalization using a skeletally anchored appliance

Eligibility criteria:
inclusion criteria: * 1- an age range from 14-17 years old. 2- all permanent teeth are present (except for third molars). 3- bilateral dental class ii malocclusion. 4- skeletal class i or mild class ii relationship. 5- normal or reduced vertical face height. 6- no posterior crowding or spaces. exclusion criteria: 1. patients who required surgery to correct skeletal discrepancies. 2. patients with congenital dentoskeletal disorders. 3. missed or mutilated teeth in maxillary arch. 4. patients with poor oral hygiene and/or periodontally compromised patients.
femoral lengthening might impair physical function and lead to structural changes in adjacent joints

Conditions: Leg Length Inequality; Leg; Lengthening; Osteoarthritis, Knee; Osteoarthritis of Hip; Quality of Life

Summary: this study evaluates function, quality of life and development of hip- and knee osteoarthritis minimum 15 years after unilateral femoral lengthening on people with idiopathic or post-traumatic anisomelia.

this study has a cross-sectional design, where patients that completed femoral lengthening more than 15 years ago and fulfills the inclusion criteria's are invited to participate. patients will undergo radiographic imaging to evaluate hip- and knee arthritis, axis deviaton and leg length discrepancy. to evaluate quality of life, function and pain, the participants will complete the forms eq-5d-5l, knee osteoarthritis outcome score (koos) and international physical activity questionnaire (ipaq). bilateral active hip and knee range of motion will be measured with hand held goniometer, and the functional tests 30 seconds sit to stand, hop tests and stair test will be conducted.

Eligibility criteria:
inclusion criteria: * patients with idiopathic or post traumatic leg length discrepancy who are lengthened with the callutasis method minimum 15 years ago exclusion criteria: * patients that are lenghtened with innate pathology resulting in shortening of the limb, angle deviation and less musculature, for example congenital femoral deficiency or fibula hemimelia. * patients with acquired leg length discrepancy who have had infection in knee or hip joint
the effect of intrawound vancomycin powder on surgical site infection in inguinal lymph node dissection

Conditions: Postoperative Complications

Summary: the study will be a pilot randomized control trial with a 1:1 patient randomization of vancomycin powder placement at the time of surgery (compared to no vancomycin placement) with the goal of reducing postoperative complications in patients undergoing an inguinal lymph node dissection for vulvar cancer. the primary objective is to measure the composite rate of postoperative complications within 30 days of inguinal lymph node dissection in patients with vulvar cancer.

the aim of the study is to investigate the impact of intrawound vancomycin powder on surgical site infections. the primary objective is to measure the composite rate of postoperative complications, including inguinal wound infection (superficial and deep surgical site infection), inguinal incision separation, and hospital readmission within 30 days of inguinal lymph node dissection in women with vulvar cancer. secondary objectives include assessing the rate of seroma or lymphocele development within 30 days of surgery. adverse events including allergic reactions (systemic or local hypersensitivity reactions) and antibiotic resistant infections (based on wound cultures) will be described. the study will be a pilot randomized control trial with a 1:1 patient randomization of vancomycin powder placement at the time of surgery. the investigators will identify women who are planning to undergo inguinal lymph node dissection for vulvar cancer and after consented will be randomized to either receive intrawound vancomycin powder in the operating room or to not receive intrawound vancomycin powder. women randomized to receive vancomycin powder will receive 1g into each of the irrigated inguinal surgical beds (maximum of 2g dose per patient). patients will be followed post operatively at their standard postoperative visits typically at 1-3 week intervals until adequate healing of their incisions. an electronic questionnaire will be administered to all patients at the postoperative visits between 3-6 weeks to assess recovery and complications. outcomes will be collected until six weeks postoperatively. the study will be conducted at a single institution

Eligibility criteria:
inclusion criteria: * women who are undergoing inguinal lymph node dissection for vulvar dysplasia * women with a prior lymph node dissection \>30 days before * women undergoing either a sentinel lymph node biopsy or full lymphadenectomy in a unilateral or bilateral groin dissection exclusion criteria: * known allergy to vancomycin * known resistance to vancomycin
alterations of conjunctival microcirculation in brain dead patients

Conditions: Brain Death

Summary: study hypothesize that ocular microcirculation is reflecting cerebral perfusion. the purpose of this study is to evaluate ocular microcirculation in brain dead patients using side dark field (sdf) videomicroscope and compare it with microcirculatory parameters of healthy volunteers.

microcirculation videomicroscopy techniques are used to evaluate a global organ perfusion in various critical conditions using limited suitable sites available for visualisation. however, ocular microcirculation may become a window to specifically cerebral perfusion due to related blood supply, close anatomical proximity and easy accessibility for videomicroscopy. cerebral perfusion mainly depends on cerebral flow and intracranial pressure and therefore we aim, for the first time, to demonstrate microcirculatory status of ocular conjunctiva in clinical conditions when cerebral flow is completely absent. in a single center open label observational study investigators analyzed conjunctival and sublingual microcirculation using sdf videomicroscopy in brain dead patients after reaching systemic hemodynamic targets to optimise perfusion of donor organs. all brain death diagnoses were confirmed by cerebral angiography. microcirculatory images obtained and analyzed using standardized published recommendations by experts in this field. microcirculation of sublingual and conjunctival areas were recorded in matching number of healthy volunteers using same techniques.

Eligibility criteria:
inclusion criteria: * diagnosed brain dead exclusion criteria: * conjunctival or sublingual mucosa damage

Keywords: conjunctival microcirculation sublingual microcirculation sidestream dark field (sdf) microscopy
an exploratory study of iliac artery branch stent for internal iliac artery reconstruction in abdominal aortic aneurysm/iliac aneurysm repair

Conditions: Aortic Aneurysm, Abdominal; Iliac Aneurysm

Summary: the purpose of this study is to evaluate the efficacy and safety of ibd stent of shenzhen xianjian company and ibe stent of american gore company in the treatment of abdominal aortic aneurysm/iliac aneurysm reconstruction of internal iliac artery

this study is a prospective observational exploratory cohort study without a control group. as a single-group target value validation study, the main evaluation indicator is the primary patency rate one year after surgery. as an exploratory study, considering the enrollment ability to facilitate data analysis, 40 subjects are enrolled in the final study, and 20 are expected to be included in each study. all enrolled patients will be followed for 12 months for cta to assess primary patency. telephone follow-up was conducted at 1, 3, 6, and 12 months for adverse events.

Eligibility criteria:
inclusion criteria: 1. patients with iliac aneurysms combined with or without abdominal aortic aneurysms and internal iliac arteries reconstructed with iliac branch stents; 2. male or female ≥18 years old, ≤85 years old; 3. life expectancy \> 2 years; 4. the patient signed the informed consent voluntarily and was able to comply with the treatment plan and complete the follow-up and examination as planned. exclusion criteria: 1. fungal or ruptured aneurysm 2. known complications of thoracic aortic aneurysm require interventional treatment 3. american association of anesthesiologists (asa) grade v 4. creatinine \> 2.5mg/dl or dialysis patients 5. nyha grade iv heart failure 6. intercalation, severe calcification, or anchoring area with thrombosis 7. severe curvature or narrowing of the iliac and/or femoral arteries, resulting in difficulty in stent delivery 8. conduct another device or drug study within 1 year of treatment 9. systemic infection 10. combined with connective tissue disease 11. known history of drug use 12. known allergies or allergies to equipment materials

Keywords: iliac artery branch stent patency rate internal iliac artery
impact of currently recommended postnatal nutrition on neonatal body composition

Conditions: Premature Birth; Preterm Birth

Summary: the purpose of this study is to gain information that may be useful in helping to figure out better or newer ways to provide nutrition to babies born premature.

babies born premature weigh significantly less at the time of hospital discharge when compared to babies born at the corresponding age. the researchers in this study believe that the lower body weight at discharge may be due to lower muscle mass. however, there is no such information available for that at this time. it is important to have this information as babies who weigh less than normal at hospital discharge may develop higher blood pressure and higher sugar levels when they are 10-15 years old. by doing this study, researchers will be able to have information about the baby's muscle mass, which will help the researchers to provide better nutrition to babies who are born premature. researchers will also be able to determine if there are any differences in the muscle/fat mass based on the type of feeding (breast milk alone, formula alone or a combination of breast milk and formula). this information may be beneficial in helping to promote the appropriate type of feeding for babies born premature.

Eligibility criteria:
inclusion criteria: * newborns \<32 weeks gestational age, singleton or multiple gestation * 34-36 weeks gestational age newborns * term healthy infants from uncomplicated pregnancy exclusion criteria: * babies with life threatening illness unlikely to survive * congenital and chromosomal anomalies

Keywords: pea pod body composition