Kornimate/medical-research-clean huggingface dataset:
affective and cognitive responses to acute bouts of physical activity and mindfulness training

Conditions: Sedentary Behavior

Summary: the purpose of the present study is to investigate the benefits of mindfulness training during an acute bout of physical activity. we will compare the combination of mindfulness training and physical activity to mindfulness training alone and physical activity alone in three 20 minute sessions.

we will investigate whether mindfulness training during a single bout (20 minutes) of physical activity influences ratings of perceived exertion, feeling states and physiological response (blood pressure and heart rate) during physical activity. changes in affect and cognitive function pre- and post- physical activity bout will also be assessed. the effects of mindfulness training during an acute bout of physical activity will be compared to mindfulness training alone and acute physical activity alone. this research will contribute to larger questions of how to increase rates of physical activity in the general population and make physical activity more enjoyable.

Eligibility criteria:
inclusion criteria: * fluent in spoken and written english * have access to internet to complete baseline and post-study assessments exclusion criteria: * respiratory, joint, or cardiovascular problems precluding physical activity participation * fail the physical activity readiness questionnaire (par-q) and are unable to obtain physician consent to participate

Keywords: mindfulness physical activity
botulinum toxin type a in the treatment of chronic anal fissure

Conditions: Chronic Anal Fissure

Summary: this study is aimed at studying the effectiveness and safety of surgical treatment of chronic anal fissure.

a chronic anal fissure is a rupture of the mucous membrane of the anal canal, lasting more than 2 months and resistant to non-surgical treatment. this condition is accompanied by a strong pain syndrome during and after defecation (defecation). this condition is most often found in young and able-bodied adults, so the issue of treatment is of particular relevance. the main cause of the development of a chronic anal fissure is a spasm of the internal sphincter. it should be eliminated first of all to ensure effective therapy. all the main treatment methods, such as medicinal relaxation of the internal sphincter with 0.4% nitroglycerin ointment, lateral subcutaneous sphincterotomy, and pneumodivulsion of the anal sphincter are aimed at its removal. however, the optimal method has not yet been developed. non-surgical treatments are often attended by relapse of disease, while surgical treatment is often complicated by intestinal contents incontinence, usually gas and loose or hard stool in some occasions (grade 3 anal sphincter insufficiency). in particular, lateral subcutaneous sphincterotomy performed in such patients is associated with an increase in the degree of anal incontinence in the early post-operative period. botulinum toxin type a application in treatment of patients with chronic anal fissure (after fissure excision) is intended to improve the therapy results, namely to reduce the frequency and duration of anal sphincter insufficiency after sphincter spasm removal (reduction in the number of patients suffering from post-operative incontinence).

Eligibility criteria:
inclusion criteria: * patients with chronic anal fissure with spasm of anal sphincter exclusion criteria: * inflammatory diseases of the colon * pectenosis * previous surgical interventions on the anal canal * iv grade internal and external hemorrhoids * rectal fistula * severe somatic diseases at the decompensation stage * pregnancy and lactation * anal sphincter insufficiency * chronic paraproctitis * fibrous polyp of the anal canal, accompanied by clinical manifestations * individual intolerance and hypersensitivity to botulinum toxin * myasthenia gravis and myasthenic syndromes

Keywords: fissure in ano anal fissure botulinum toxin a chronic anal pain fecal incontinence spasm of the internal sphincter anal sphincter insufficiency
curcumin; rose bengal; denture stomatitis

Conditions: Candida Albicans Infection; Cigarette Smoking

Summary: cigarette smoking in conjugation with bad oral hygiene is considered a typical predisposing factor for many oral diseases including denture stomatitis. this study investigated the effect of rose bengal (rb)-and curcumin (cur)-mediated photodynamic therapy (pdt) in comparison with nystatin therapy in the intervention of denture stomatitis in cigarette smokers. overall, 45 habitual cigarette smokers aged \~58 years having denture stomatitis were categorized into three groups: group-i - rb-mediated pdt, group-ii - cur-mediated pdt, and group-iii - nystatin therapy. the primary outcome of the interest was: counts of candida colony from denture surface and palatal mucosa, calculated as cfu/ml, whereas the prevalence of candida species determined in 3 research groups comprised the secondary outcome. oral swab specimens were gathered from the denture surfaces and palatal mucosa. all clinical assessments were performed at baseline, 6 weeks, and 12 weeks. c. albicans was the most prevalent yeast identified on both denture surfaces and palatal mucosa, followed by c. tropicalis and c. glabrata. a considerable decrease in the cfu/ml scores were observed in group-i and group-ii at the end of the interventions and on the 12-week follow-up (p\<0.05). group-i, ii, and iii demonstrated clinical efficacy rates of 53%, 51%, and 49%, respectively. cur-and rb-mediated pdt was found to be as effective as topical nystatin therapy for the intervention of denture stomatitis among cigarette smokers.


Eligibility criteria:
inclusion criteria: the inclusion criteria consisted of the following: (1) completely edentulous participants; (2) removable complete denture wearers diagnosed with denture stomatitis (loss of filiform papillae, erythema, and feeling of mucosal burning); and (3) habitual cigarette smokers (individuals smoking at least 1 cigarette per day since ≥3 years). exclusion criteria: the exclusion criteria consisted of the following: (1) individuals who received steroids, antifungals, or antibiotics over the past 90 days before the initiation of the study; (2) lactating or pregnant women; (3) individuals who had been using the same denture over the past ten years; individuals who underwent cancer treatment (chemotherapy or radiotherapy); (5) patients who are immunocompromised, anemics, or diabetics; (6) habitual alcohol drinkers; and (7) participants who refused to sign the informed consent document.

Keywords: candida albicans curcumin nystatin photodynamic therapy rose bengal
preoperative oral carbohydrate treatment minimizes insulin resistance

Conditions: Insulin Resistance

Summary: insulin resistance is a positive protective reaction against surgery .this resistance has some negative consequences for patient health. it is associated with infectious complications. at the same time, postoperative insulin resistance has been shown to correlate with the length of postoperative stay in hospital. recently several clinical studies have shown that a carbohydrate-rich drink given 2 h before surgery diminishes postoperative insulin resistance in patient. the aim of our study is to investigate the influence on insulin resistance in patient with diabetes.

insulin resistance is a positive protective reaction against surgery . as a response to surgery, activation of neuroendocrine and inflammation systems occurs as a protective reaction. however, this resistance has some negative consequences for patient health. it is associated with infectious complications. at the same time, postoperative insulin resistance has been shown to correlate with the length of postoperative stay in hospital. recently several clinical studies have shown that a carbohydrate-rich drink given 2 h before surgery diminishes postoperative insulin resistance in patient. the aim of our study is to investigate the influence on insulin resistance in patient with diabetes.

Eligibility criteria:
inclusion criteria: * patients underwent elective open colorectal resection for colorectal carcinoma and electric orthopedic surgery exclusion criteria: * weight loss greater than 10 per cent during the previous 6 months * renal insufficiency (creatinine, \> 3 mg/dl; hemodialysis) * hepatic insufficiency (child-pugh class, ≥ b) * gastro-oesophageal reflux disease * gastrointestinal obstruction or conditions (including pharmacological treatment) known to affect gastric emptying rate

Keywords: insulin resistance diabetes mellitus carbohydrate
combination of dpmas and low volume pe for patients with hbv related aclf

Conditions: Hepatitis B, Chronic; Acute-On-Chronic Liver Failure

Summary: this study is to investigate investigate the safety and efficacy of double plasma molecular adsorption system with sequential low-dose plasma exchange in treating hepatitis b virus-related acute-on-chronic liver failure.

hepatitis b virus (hbv) related acute-on-chronic liver failure (aclf) is a serious condition with high mortality rate in china. but there still lacks of effective therapies in treatment of hbv related aclf, except liver transplantation. non-bioartificial liver support system treatments may be effective due to previous clinical data. plasma exchange (pe) and double plasma molecular adsorption system (dpmas) are two common ways in clinical practice. this study is to investigate the clinical efficacy and safety of combination treatment of dpmas and low volume pe in patients with hbv related aclf. this study will be completed in 6 medical center. two hundred patients with hbv related aclf enrolled in this study are divided into trial group (dpmas, low volume pe, and comprehensive internal medical treatment) and control group (comprehensive internal medical treatment). symptoms, signs, laboratory tests results, adverse events, mortality rates are recorded from treatment baseline to 12 weeks.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of chronic hepatitis b virus infection (positive hepatitis b surface antigen or positive hepatitis b virus dna \> 0.5 year); 2. age from 18 to 65 years old; 3. clinical diagnosis of liver failure (serum total bilirubin level \> 10 times upper limit of normal; prothrombin time activity \ 1.5); 4. platelets \> 50\*10 e9/l. exclusion criteria: 1. other active liver diseases; 2. hepatocellular carcinoma or other malignancy; 3. pregnancy or lactation; 4. human immunodeficiency virus infection or congenital immune deficiency diseases; 5. severe diabetes, autoimmune diseases; unstable infarction due to cardio-cerebrovascular events; 6. other important organ dysfunctions or transplantation; 7. severe complications including severe infection, gastrointestinal bleeding, hepatic encephalopathy, hepatorenal syndrome; 8. patients can not follow-up; 9. investigator considering inappropriate.

Keywords: hepatitis b virus acute-on-chronic liver failure double plasma molecular adsorption system plasma exchange
temporary pacemaker in transcatheter aortic valve implantation patients

Conditions: Aortic Stenosis

Summary: during transcatheter aortic valve implantation (tavi) procedure, a new valve is implanted. the valve can be corevalve (medtronic company) or edward sapiens (edwards company). all tavi patients require a temporary pacemaker(pmk), which is usually performed by insertion of a standard temporary electrode through the femoral vein. the temporary pmk is associated with a small but significant rate of complications. the pmk is usually removed immediately at the end of the tavi procedure, only when using the edward sapiens valve. the corevalve valve is more associated with conduction complications, and thus the pmk is later removed in these cases. pmk complications seen include: * right ventricle perforation by temporary electrode, leading to pericardial bleeding, in some cases with tamponade * infection * electrode dislocation causing in-effective pacing (and/or sensing) * prolonged bed rest * prolonged hospitalization * access related problems (hematoma, pneumothorax) in a review of a large cohort (1) of patients from milan (jacc 2012) the rate of tamponade was 4.3% most of which was associated with the temporary pmk.

the investigators had experienced not infrequent occurrences of temporary electrode associated tamponade, either acutely after transcatheter aortic valve implantation (tavi) completion, or delayed, in association with the electrode removal. the tamponade rate in patients with a temporary pacemaker(pmk) was 14/150 (9.3%). not all tamponade cases were related to the temporary pmk, 2 occurred in the setting of catastrophic annular rupture and one of the first cases was related to the left ventricle stiff wire. the investigators also noted a significant prolongation of bed rest and hospital stay in patients with temporary pmk. using a flexible permanent pacing electrode which is actively fixed to the right ventricle and is placed through the jugular vein will reduce pacing-related complication rates (due to the flexibility of the electrode), time to ambulation (due to the fixation of the electrode), hospital stay and also unnecessary pmk. cost will also be reduced due to prevention of complications and reduction in intensive cardiac care unit time. procedure time might be slightly prolonged since the placement of the standard electrode is more timely, however this prolongation is negligible, and the benefits of the flexible permanent pacing electrode are worth this prolongation

Eligibility criteria:
inclusion criteria: * all tavi patients exclusion criteria: * existing contraindication for either femoral or jugular venous access * refused informed consent * permanent pmk * platelets count less than 50 k.
decamp 1 plus: prediction of lung cancer using noninvasive biomarkers

Conditions: Pulmonary Disease

Summary: decamp 1 plus aims to improve the efficiency of the diagnostic evaluation of patients with indeterminate pulmonary nodules (8-25 mm). molecular biomarkers for lung cancer diagnosis measured in minimally invasive and non-invasive biospecimens may be able to distinguish between malignant or benign indeterminate pulmonary nodules in high-risk smokers. ultimately, this study aims to validate molecular as well as clinical and imaging biomarkers of lung cancer in individuals with indeterminate lung nodules.

the detection of early lung cancer among military personnel (decamp) consortium is a multidisciplinary and translational research program that previously initiated the decamp-1 and decamp-2 studies for lung cancer early detection. now, with the support of johnson and johnson, 3 veterans administration hospitals (vah), 3 military treatment facilities (mtf) and 12 academic hospitals as clinical study sites, several molecular biomarker laboratories, along with biostatics, bioinformatics, pathology and biorepository cores, we are expanding our work in lung cancer early detection.

Eligibility criteria:
inclusion criteria: * radiologic diagnosis of solid indeterminate pulmonary nodule (0.8 to 2.5 cm) identified in the past 3 months or semi-solid (mixed density) nodule with solid component of at least 0.6 cm identified in the past 12 months; must be of appropriate size at enrollment. * ct scan completed within 3 months prior to enrollment * able to tolerate all biospecimen collection as required by protocol * able to comply with standard of care follow up visits including clinical exams, diagnostic work-ups, and imaging for approximately three years from enrollment * able to complete the patient lung history questionnaire with study staff arm 1 - screening * age 55-77 years old * current and former smokers with 30 pack-years or more(and quit less than 15 years ago) arm 2 - incidental * age \> 45 years old * current and former smokers with 10 pack-years or more(and quit less than 15 years ago) exclusion criteria: * history or previous diagnosis of primary lung cancer, metastatic lung cancer, or any other non-lung cancer within 5 years (not including non-melanoma skin cancer) * symptoms of lung cancer (unexplained weight loss 10 lbs or more in 3 months, recent hemoptysis) * diagnosis of pure ground glass opacities for the target lesion on chest ct within the last 12 months (i.e., mixed features on the target lesion and pure ground glass opacity on non-target lesions are acceptable as mentioned above)

Keywords: indeterminate pulmonary nodules molecular biomarkers for lung cancer diagnosis imaging for lung cancer diagnosis high risk smokers
evaluation of feasibility and aesthetic outcomes of benelli technique for nipple sparing mastectomy in surgical treatment of grade 3 and 4 gynecomastia

Conditions: Surgical Managment of Gynecomastia

Summary: gynecomastia is the benign proliferation of male breast tissue caused by an increase in the estrogen/androgen activity ratio. it manifests itself physiologically (adolescence, puberty, and old age) as well as pathologically (androgen insufficiency caused by drugs or disease, testicular tumors, hyperthyroidism, and chronic renal failure). * in spite of the variety of methods and tools such as (liposuction and circumareolar inframammary inscion ) used in gynecomastia surgery, in gynecomastia the results are satisfactory in grades 1 and 2 while grades 3 and 4 gynecomastia present a surgical challenge. * as some postoperative frustrating problems still cannot be completely eliminated, the most common of these are a saucer-like deformity (over resection under areola), bleeding, followed by seroma, infection, ischemic necrosis of nipple areola complex residual gynecomastia (under resection), persistence of inframammary fold, contour irregularities, and asymmetries between breasts. * the objective, in this research, is to demonstrate the the role of benelli technique in removal of gynecomastia grade 3 and grade 4 in clinical and cosmetic outcomes

• the aim of this study the investigator determines the feasibility and cosmetic outcomes of benelli technique for nipple sparing mastectomy in cases of grade 3 and 4 gynecomastia

Eligibility criteria:
inclusion criteria: * adult male complaining of unilateral or bilateral grade 3 and 4 gynecomastia * pseudo gynecomastia following massive weight loss with excess skin and laxity exclusion criteria: * patients with chronic liver failure * hyperthyroidism * malignant mass * diabetics * smokers * patients with medical treatment as anabolic steroids .
invasive validation of non-invasive central blood pressure measurements using oscillometric pulse wave analysis

Conditions: Arterial Hypertension; Coronary Heart Disease

Summary: there is growing evidence that central blood pressure is a better predictor of hypertensive end-organ damage and cardiovascular outcome than routine brachial readings. the investigators aimed to evaluate the accuracy of a novel device for the non-invasive determination of central blood pressure based on automated oscillometric radial pulse wave analysis.


Eligibility criteria:
inclusion criteria: * patients undergoing routine coronary angiography exclusion criteria: * inability to give informed consent * hemodynamic instability

Keywords: central blood pressure measurement oscillometric radial pulse wave analysis
evaluation of executive function with virtual reality among people with schizophrenia

Conditions: Schizophrenia

Summary: this cross-sectional study included patients that diagnosed with schizophrenia, aged 18-55, 20 of which hospitalized in mental health department and 20 in medical follow-up. different test will be administered, in two or three sessions, to evaluate cognitive ability, function ability and participation. the results of the vis shopping task performance (statically \& dynamically) and its correlation with the cognitive and function tests as well as the participation questionnaire will be examined. these findings will indicate whether the shopping task is valid to assess executive functions for people with schizophrenia and whether it is ecologically valid.

background: schizophrenia often reflect by decrease in executive functions that may cause difficulty in instrumental activities of daily living (iadl). we've found it very difficult to simulate these functions with the existing tools in the clinic and to assess iadl accordingly. the use of virtual reality (vr) became popular in the last decade to overcome these limitations in clinical practice and assessment of functioning in iadl. vr is a computer program that simulates a functional environment in which the subject impacts on events through various actions. recent studies indicated that vr can be used to assess cognitive abilities and functioning of population with schizophrenia. as far as we know, no researches were performed using virtual interactive shopping (vis) in this population, nor did dynamic evaluation was used to identify potential learning abilities. the aim of this study is to examine the validity of the shopping task in the vis, performed statically and dynamically, in order to assess executive function, and the ability to reflect cognitive, functional and participation ability among people that diagnosed with schizophrenia. method: this cross-sectional study included patients that diagnosed with schizophrenia, aged 18-55, 20 of which hospitalized in mental health department and 20 in medical follow-up. different test will be administered, in two or three sessions, to evaluate cognitive ability, function ability and participation. the results of the vis shopping task performance (statically \& dynamically) and its correlation with the cognitive and function tests as well as the participation questionnaire will be examined. these findings will indicate whether the shopping task is valid to assess executive functions for people with schizophrenia and whether it is ecologically valid.

Eligibility criteria:
inclusion criteria: * schizophrenia or scizoeffective diagnosis, hebrew language proficiency, three weeks of anti-psychotic drug treatment exclusion criteria: * score of under 70 in the 3ms (screen test), physical disability, neurological diagnosis (ex. dementia)

Keywords: virtual reality
risk factors and complications of ventral hernia repair

Conditions: Ventral Hernia

Summary: the aim of this study is to evaluate risk factors and complications of ventral hernia repair. a retrospective study of journal files with patients undergoing ventral hernia repair, and an analyses of complications by use of the clavien-dindo classification of surgical complications.


Eligibility criteria:
inclusion criteria: * surgically treated ventral hernia repair exclusion criteria: * all surgically treated patients are included