Kornimate/medical-research-clean huggingface dataset:
effects of home-based mirror therapy combined with task-oriented training for patients with stroke

Conditions: Stroke

Summary: the specific aims of this study will be: 1. to compare the immediate and retention treatment effects of the patients receiving home-based mirror therapy combined with task-oriented training (mtot) with a hospital-based mtot group and a hospital conventional rehabilitation group on different aspects of outcomes. 2. to examine the feasibility, satisfaction, and safety of this novel home-based mtot program. 3. to investigate the factors that may affect the efficacy of home-based stroke rehabilitation.

in this 3-year study project, we will design a single-blind randomized controlled trial (1) to compare the treatment effects of home-based mtot with a hospital-based mtot group and a hospital conventional rehabilitation group, (2) to investigate the feasibility, satisfaction, and safety of this home-based program, and (3) to identify the factors that might influence treatment outcomes. an estimated total of 90 patients with stroke will be recruited in this study. all participants will be randomly assigned to receive home-based mtot or hospital-based rehabilitation for a 4-week training period (a total of 12 sessions). before the first treatment session, a client-centered questionnaire will be administered to each patient for identifying individual needs and goals. feasibility evaluation and caregiver's wellbeing will be also assessed. outcome measures will be conducted at baseline, immediately after treatment, and 3 months follow-up.

Eligibility criteria:
inclusion criteria: * diagnosed as having a unilateral stroke * at least 3 months after stroke onset * from 20 to 80 years of age * having completed acute rehabilitation care or discharged home * a baseline score of the fugl-meyer assessment (fma) of 20 to 60 * able to follow the therapy instructions (cognition status will be measured by the montreal cognitive assessment) * capable of participating in therapy and assessment sessions. exclusion criteria: * neglect * global or receptive aphasia * major medical problems * comorbidities that influenced ue usage or caused severe pain

Keywords: home-based rehabilitation stroke combination therapy client-centered approach post-acute
urdu version of core outcome measure index - neck scale: reliability and validity study

Conditions: Chronic Neck Pain

Summary: the purpose of this study is to culturally adapt and translate core outcome measure index-neck scale into urdu language as well as to investigate the reliability and validity in pakistani population. also check its correlation with neck disability-index, neck-pain and the disability-scale and functional-rating-index.

the english version of the core outcome measure index-neck scale will be translated and culturally adapted urdu language. in patients who suffer from chronic-neck pain, core outcome measure index-neck scale will be distributed among one hundred and twenty participants choose a convenience sampling technique based on pre-defined inclusion and exclusion criteria. to test intra and inter observation reliabilities for the final core outcome measure index-neck scale, neck-pain and the disability scale, functional-rating-index and neck-disability-index questionnaire will be filled on the same day, by two observers, and for the inter-observer's assessment, with an interval of 30 minute between the first and the second application. third assessment will be carried out after 7 days by for intra-observer assessment. data will be entered and analyzed using statistical package of social sciences software version 24. internal consistency will be analyzed by using cronbach-alpha-value. test-retesting reliabilities will assesses using the intraclass correlation coefficient. core outcome measure index-neck scale will be evaluated for content validities, construct validities, and responsiveness.

Eligibility criteria:
inclusion criteria: * individuals, including both male and females (age ≥18). * participants with chronic-neck pains lasting more than three months duration. * participants with sufficient knowledge and understanding urdu language. exclusion criteria: * participants with the history of neck-pains due to deformity, existing central or peripheral nervous disorders and cervical spinal cord fracture were excluded. * participants having systematic diseases (tumor or articular diseases). * participants with any pertinent comorbidities, including heart attack, cancer, cognitive impairment's and mental disorders were also excluded.

Keywords: core outcome measure index-neck scale chronic neck pain reliability validity urdu version
survey of the need for information on fertility and menopause-related treatment effects among hsct patients

Conditions: Stem Cell Transplantation

Summary: primary objective: - to understand the importance of receiving information on fertility- and menopause-related treatment effects for female patients undergoing hematopoietic stem cell transplantation.

researchers are currently conducting a survey on how important it is to women who are having a stem cell transplant to have information about the effects of the treatment on their fertility (their ability to have children) and on the risk of early menopause. researchers know that some women who had transplants think that the information that they received may have been lacking or was not appropriate for their needs. therefore, researchers would like to ask women who have had stem cell transplants at m. d. anderson cancer center to report what kind of information they got and would like to have gotten before or during their treatment.

Eligibility criteria:
inclusion criteria: * female patients who had a hematopoietic stem cell transplantation between january 1987 and september 2004 at m. d. anderson cancer center. * age 16 to 50 years at the time of the transplant. exclusion criteria: * history of ovarian cancer. * history of hysterectomy/oophorectomy * non-english speaking patients

Keywords: fertility menopause hematopoietic stem cell transplantation questionnaire survey
physical and psychological profiles associated with patient's preference for esrd treatment

Conditions: End Stage Renal Failure

Summary: highlighting the relationship between psychological and physical profiles and patient's preference to better understand the patient's treatment preference and improve the information provided.

ckd is a public health problem with a prevalence of 10% in general population. for patients reaching the making decision to treat esrd with renal replacement therapy is a complex process and needs to be shared between patients, family, physician and nephrologist. systematic information delivery about several treatments of esrd is recommended for patients and his family (hemodialysis, peritoneal dialysis, kidney transplantation and conservative treatment). some studies on the preference of patients for renal replacement therapy reported a choice for pd about 50% while the registers report a low diffusion of pd (around 10%). since 2009 we propose a systematic information about the different therapeutic options for esrd and identified some clinical characteristics associated to patient's preference. however we want to know if psychological or physical phenotype is associated to patient's preference. the objective of the study is to highlight the relationship between psychological and physical profiles and patient's preference to better understand the patient's treatment preference and improve the information provided.

Eligibility criteria:
inclusion criteria: * more than 18 years * ckd with estimated gfr below 20 ml/min/1.73m2 without dialysis treatment * patient who accepts information delivery about treatments of esrf * patient who accepted and signed the informed consent * subject beneficiary of a social security system exclusion criteria: * inability to achieve psychological tests * inability to achieve physical tests
identification of jaundice in newborns using smartphones

Conditions: Jaundice, Neonatal; Hyperbilirubinemia, Neonatal

Summary: neonatal jaundice is a common and most often harmless condition. however, when unrecognized it can be fatal or cause serious brain injury. three quarters of these deaths are estimated to occur in the poorest regions of the world. the treatment of jaundice, phototherapy, is in most cases easy, low-cost and harmless. the crucial point in reducing the burden of disease is therefore to identify then children at risk. this results in the need for low-cost, reliable and easy-to-use diagnostic tools that can identify newborns with jaundice. based on previous research on the bio-optics of jaundiced newborn skin, a prototype of a smartphone application was developed and tested in a pilot study and the application refined. this smartphone application will now be evaluated in a clinical trial set in two hospitals in norway. the smartphone application gives immediate estimates of bilirubin values in newborns, and these estimates will be compared to the bilirubin levels measured in standard blood samples, as well as the results from ordinary transcutaneous measurement devices.

the smartphone jaundice app system works by taking pictures of newborns with a custom-made color calibration card placed on their chest. this makes it possible to measure the skin color precisely regardless of the specific light source that is used to illuminate the newborn. the measured skin color is then compared with items in a database of simulated newborn skin colors. these simulated newborn skin colors have been created using numerical simulations of how light moves through skin, with varying skin parameters including, but not limited to, skin thickness, blood concentration, melanin, and of course bilirubin, the pigment that causes jaundice. by comparing the measured skin color with the simulated skin colors that are most similar to it, the investigators can then estimate the bilirubin concentration in the newborn's skin by e.g. averaging the bilirubin concentrations used to create these simulated skin colors. in a group of 200 newborns with varying degree of jaundice, correlation between smartphone bilirubin estimates will be compared with total serum bilirubin and standard transcutaneous bilirubinometry.

Eligibility criteria:
inclusion criteria: * born in st.olavs hospital, trondheim or in haugesund hospital, norway * born with gestational age \>36+6 * birth weight ≥ 2500g and \<4500g * age 1 - \<15 days * are having a blood sample performed, as newborn screening or for jaundice assessment exclusion criteria: infants needing intensive treatment. this includes: * infants in the need for respiratory support * infants with conditions that could compromise skin circulation, as sepsis, heart failure or other * infants that have received phototherapy

Keywords: diagnosis cell phones infant, newborn skin pigmentation
preoperative image-based education effect on postoperative satisfaction of patients undergoing first-time dermatologic surgery

Conditions: Skin Cancer; Skin Wound

Summary: this research study aims to understand whether visual and written education on wound appearance can improve patients' experience and understanding of what their wound will look like following dermatologic surgery.

undergoing surgery is a stressful process for many patients. by its nature, dermatologic surgery carries additional stressors given that it is performed on the skin, a very cosmetically sensitive area. in our dermatologic surgery practice, we have found that patients are often surprised by the length of their surgical wound immediately post-surgery; many have expressed confusion about the length of the wound relative to the much smaller targeted lesion. our research study will utilize image-based education prior to patients' first dermatologic surgery to determine whether this intervention helps patients feel more satisfied with their wound appearance immediately post-surgery. our primary hypothesis is that patients who are undergoing dermatologic surgery for the first time will benefit from image-based education about the surgical wound closure process. we hypothesize that a greater proportion of such patients would feel more satisfied and less distressed with the cosmetic outcomes immediately after their surgery relative to patients who did not receive image-based education. if this hypothesis is found to be true, we will conclude that there is a need for better patient education prior to their dermatologic surgery procedure. we hope that this study will create a framework for sharing educational resources with patients so that they may set expectations as to surgical outcomes. these findings may also be relevant to other surgical procedures where patient satisfaction would be improved by the implementation of pre-operative education.

Eligibility criteria:
inclusion criteria: * inclusion criteria: adult patients (ages 18-100) who will be undergoing dermatology surgery at johns hopkins. we will include only patients who are undergoing their first dermatology surgery. only patients whose incisions are closed with primary closure will be eligible. exclusion criteria: * patients who have already undergone dermatology surgery. * patients whose incisions are not closed with primary closure

Keywords: mohs surgery wide local excision
an observational study of adjuvant treatment with capecitabine (xeloda) in combination with oxaliplatin in participants with stage iii colon cancer

Conditions: Colorectal Cancer

Summary: this observational study evaluates the efficacy and safety of capecitabine in combination with oxaliplatin in the adjuvant setting in participants with stage iii colon cancer. data were collected from each participant for up to 36 months or until disease recurrence.


Eligibility criteria:
inclusion criteria: * adult participants, \>/= 18 years of age * treatment in line with the currently approved indication in the summary of product characteristics exclusion criteria: * contraindications according to the current summary of product characteristics

Keywords: colorectal cancer adjuvant setting capecitabine oxaliplatin
study of immunity dysfunction induced by extracorporeal assistance (ecmo / ecls)

Conditions: Acute Respiratory Distress Syndrome; Cardiogenic Shock

Summary: study of immunosuppression biomarkers in patients with ards or cardiogenic shock with ecmo / ecls, compared to patients with ards or cardiogenic shock without ecmo / ecls


Eligibility criteria:
inclusion criteria: * patient older than 18 years old * patient hospitalized in an intensive care unit * patient whose initial ards or cardiogenic shock began less than 5 days before admission * patients hospitalized for ards or cardiogenic shock with ecmo / ecls or - patients hospitalized for ards or cardiogenic shock without ecmo / ecls exclusion criteria: * opposition of patient, relative or legal representative for participation in the study * pregnant woman * pre-immunodepression * implementation of immunosuppressive therapy such as chemotherapy, cyclophosphamide, high-dose corticosteroids (\> 0.5mg / kg / day).
knowledge levels and experiences of intensive care nurses on the prevention of pressure sores: mixed method

Conditions: Nurses; Pressure Ulcer; Critical Care

Summary: this research aims to determine the knowledge levels and practices of intensive care nurses regarding the prevention of pressure sores. the main questions it aims to answer are: 1. what is the level of knowledge of intensive care nurses regarding the prevention of pressure sores? 2. what is the impact of sociodemographic characteristics of intensive care nurses on their knowledge level regarding the prevention of pressure sores? 3. what are the experiences of intensive care nurses regarding their practices for the prevention of pressure sores? in this research, a survey and interview technique will be applied to determine the knowledge levels and experiences of nurses working in adult intensive care units regarding the prevention of pressure sores and their practices.

this study is a mixed method research conducted to determine the knowledge levels and experiences of nurses working in adult intensive care units regarding the prevention of pressure sores. in accordance with the purpose of the study, parallel data type in convergent parallel mixed design will be used as the research design. the quantitative phase will be conducted as a descriptive survey, and the qualitative phase will be conducted as a descriptive case study design. in this mixed design, equal priority, parallel timing and combining results during interpretation are planned. the research will be conducted with nurses working in adult intensive care units of a public hospital located in a city center. \&#39;sociodemographic form\&#39;, \&#39;pressure ulcer knowledge level assessment tool 2.0- updated version\&#39;, \&#39;semi-structured interview form\&#39; will be used as data collection tools. within the scope of our research questions, quantitative and qualitative data will be analyzed independently of each other. in the discussion section, the integration of quantitative and qualitative evidence will be interpreted by making analytical generalization by combining data without transformation.

Eligibility criteria:
inclusion criteria: * nurses working in adult intensive care units agreeing to participate in the research exclusion criteria: * nurses who do not work in adult intensive care units nurses who did not agree to participate in the research

Keywords: intensive care nurse pressure ulcer
an exploratory study to evaluate fmx-8 to treat anemia in ckd

Conditions: Anemia in Chronic Kidney Disease

Summary: fmx-8 is a new type of drug being tested for the treatment of anemia in chronic illnesses.


Eligibility criteria:
inclusion criteria: * a documented hemoglobin level to be less than 10 g/dl at screening * diagnoses of ckd 4 or 5 * body mass index (bmi) between 18 kg/m2 and 42 kg/m2, inclusive, based upon the height and weight at screening * ferritin levels ≥100 ng/ml or tsat ≥20% at screening * erythropoietin (epo) level greater than 8 ng/ml * able to provide written informed consent * able to understand and follow all trial procedures * willing to use contraception as detailed in the protocol exclusion criteria: * receipt of red blood cell (rbc) transfusion within four weeks before screening * overt gastrointestinal bleeding or other bleeding episode that required transfusion within 2 months prior to screening * infection necessitating antibiotic or anti-viral treatment within a month prior to screening * requiring coumadin (warfarin), pradaxa®, eliquis®, or xarelto® * hemoglobinopathies such as homozygous sickle-cell disease or thalassemias of all types * active hemolysis or chronic hypoxia * active malignant diseases (except non-melanoma skin cancer) or life expectancy less than 6 months * chronic, uncontrolled or symptomatic inflammatory disease or non-renal cause of anemia such as rheumatoid arthritis, systemic lupus erythematosus, hiv, or systemic acute infection * on immunosuppressive therapeutics except topical corticosteroids or nasal sprays * chronic congestive heart failure (new york heart association class iii, iv) * significant hypertension (≥90 diastolic) based on a sitting diastolic blood pressure at screening * kidney transplant within the past year: patients who are off immunosuppressive agents following a failed transplant are eligible for the trial * end-stage liver disease * known hypersensitivity to recombinant protein therapies * female patients who are pregnant or breast feeding * previous exposure to fmx-8 * previous exposure to epogen®, procrit® (erythropoietin) aranesp® (darbepoietin alpha), omontys® or hematide® (peginesatide) anemia treatment * uncontrolled hyperparathyroidism (pth \>750) based upon latest pth determination within the past 4 months * inability to comply with the trial scheduled visits

Keywords: chronic kidney disease ckd anemia of chronic illness
albuterol hfa mdi in pediatric participants with asthma

Conditions: Asthma

Summary: the primary objective of this study is to evaluate the chronic-dose and efficacy of albuterol-hfa-mdi relative to placebo in pediatric asthmatics.


Eligibility criteria:
inclusion criteria: * male and female child aged 4-11 years, inclusive asthma of a minimum of six months duration that has been stable for at least four weeks prior to screening. exclusion criteria: * hospitalization for acute asthma exacerbation greater than two years in 12 months prior to screening and/or received er treatment or hospitalization for asthma exacerbation.

Keywords: pediatric, asthma, albuterol-hfa and placebo
acetaminophen vs placebo in the pre-operative setting and outcomes on post-operative pain, nausea and vomiting

Conditions: Post Operative Pain; Post Operative Nausea and Vomiting

Summary: the purpose of this study is to determine whether a single dose of iv acetaminophen can improve post-operative pain, nausea, and vomiting in the outpatient setting. patient satisfaction, time to readiness of discharge, and the amount of opiates post operatively will also be measured.

the purpose of this study is to determine if using a one time pre-operative dose of iv acetaminophen has an effect on post-operative nausea, vomiting, and pain. this is a randomized, double-blind, placebo-controlled prospective study on patients from the katzmann breast center undergoing outpatient breast surgery (including excisional biopsy, lumpectomy, sentinel lymph node biopsy, axillary node dissection, or ductal excision). iv acetaminophen (paracetamol) has been in europe and other countries. in the u.s. the fda approved iv acetaminophen (ofirmev) in november of 2010. since then, it has been used in many different ways, but most commonly in the first 24 hours post operative recovery period. there will be two arms included in this study. patients in arm one will receive a one gram dose of iv acetaminophen in the pre-operative area. patients in arm two will receive a dose of the placebo (iv normal saline). the medication will be disguised in the same bag as the normal saline, so no one (including the patient) in the pre-operative area will know which arm the patient is in. this prospective, randomized, double blind study will compare post-operative nausea, vomiting, and pain rates in patients from both arms. the primary endpoint of this study will be to compare post-operative pain in patients receiving a pre-operative dose of iv acetaminophen to patients receiving the normal saline placebo. secondary endpoints will include post-operative nausea and vomiting, recovery times, and overall satisfaction of pain management throughout their experience (assessed on post operative day one). if this study shows that iv acetaminophen given in the pre-operative setting decreases post-operative nausea, vomiting, and/or pain and/or shortens recovery time, and improves patient satisfaction in regards to their pain management, it could also become a routine medication given to all patients in the pre-operative setting.

Eligibility criteria:
inclusion criteria: each of the following must be met: * greater than or equal to 18 years of age. * female * undergoing outpatient breast surgery (unilateral or bilateral surgery) exclusion criteria: if any of the following apply: * history of an allergy or hypersensitivity to acetaminophen (oral, rectal, or iv) * chronic alcoholism * severe deficiency of liver and/or kidney * any patient unable to sign informed consent * pregnancy * any patient currently enrolled in another experimental protocol