Kornimate/medical-research-clean huggingface dataset:
addressing violence and hiv care among transgender women

Conditions: Acceptability of Health Care; HIV Infections

Summary: this project seeks to adapt and pilot a trauma-informed combination intervention named 'kickin' it with the gurlz' that was designed with, for, and by transgender women of color to improve hiv care continuum outcomes. the intervention components include a violence and gender affirmation screening tool, a peer-led adaptation of seeking safety, and individual-level peer navigation sessions. the project will examine the feasibility, acceptability, and preliminary promise of the multicomponent by conducting a one-arm pilot with 30 transgender women of color who have a history of trauma. participants will complete baseline, immediate post-intervention, and 3-month follow up assessments.

this project seeks to evaluate the feasibility and acceptability of the trauma-informed combination care intervention to improve hiv care continuum outcomes including the development of community-informed strategies for subsequent rcts. we will conduct a one-arm pilot of the adapted multicomponent trauma-informed intervention named "kickin it with the gurlz." this project will collect feasibility and acceptability data related to identifying, recruiting, enrolling, intervening with, and retaining participants (i.e. recruitment length, screening procedures, feasibility of conducting sessions, intervention acceptability, retention rates, feasibility of verifying self-reported and medical chart review data on viral load and exit interviews with participants and staff at program conclusion). the study will recruit 30 participants into the pilot study. participants will complete baseline, end of program, and 3-month post-intervention follow-up surveys. exit interviews and interviews with key stakeholders will identify strategies for implementing trauma-informed hiv treatment efficacy trials with transgender women of color within close-knit communities, such as acceptable and feasible control conditions, acceptable and feasible violence and gender affirmation screening, biomedical confirmation methods, contamination concerns, and potential changes needed within existing health care systems.

Eligibility criteria:
inclusion criteria: * at least 18 years old * assigned male at birth; identifies as female, transgender woman, or another feminine gender identity * self-identifies as a person of color (any racial/ethnic identity except non-hispanic white) * self-reports as hiv-positive * history of trauma (i.e., endorses at least 2 items on the adapted trauma history screener which includes ipv and experiencing or witnessing other forms of violence for transgender women * living or willing to travel to detroit * english-speaking * willing and able to provide informed consent. exclusion criteria: • evidence of severe cognitive impairment or active psychosis that may impede ability to provide fully informed consent
investigation of the safety and efficacy of eszopiclone in insomnia patients

Conditions: Insomnia

Summary: to investigate the safety and efficacy of administration of eszopiclone for 4 weeks in insomnia patients.


Eligibility criteria:
inclusion criteria: 1. insomnia participants who did not take eszopiclone before assessment 2. participants who receive assessment by using sleep questionaries

Keywords: insomnia
contrast-associated acute kidney injury in patients with different types of coronary artery disease

Conditions: Coronary Artery Disease; Angina, Unstable; Angina, Stable; STEMI - ST Elevation Myocardial Infarction; NSTEMI - Non-ST Segment Elevation MI; Contrast-induced Nephropathy; Acute Kidney Injury

Summary: the goal of the study is to assess the prevalence of contrast-associated acute kidney injury in patients with stable coronary artery disease, st-elevation myocardial infarction and unstable angina/nstemi, assess the risk factors of contrast-induced acute kidney injury development and the influence of contrast-induced kidney injury on 1-year prognosis.


Eligibility criteria:
inclusion criteria: * males and females aged 18-80 * stable cad receiving optimal medical treatment requiring pci or stemi or nstemi * intra-arterial injection of iodinated contrast media * informed consent exclusion criteria: * age less than 18 * pregnancy, lactation * refuse to sign the informed consent * contraindications for pci * other conditions affecting prognosis (oncology, liver failure etc) * ckd stage 4-5 * patients receiving nephrotoxic drugs

Keywords: coronary artery disease iodinated contrast media stable angina unstable angina stemi nstemi pci acute kidney injury
trans-abdominal fetal pulse oximetry: tissue light scattering

Conditions: Fetal Distress

Summary: this study is being conducted to study light scattering properties of maternal-fetal tissue.

the iss customized commercial frequency domain oximeter is used to obtain light scattering information from the maternal abdomen for 10-20 minutes preoperatively and postoperatively in subjects who are having a scheduled c-section.

Eligibility criteria:
inclusion criteria: 1. pregnant women with singleton pregnancies, vertex or breech presentation, scheduled for non-emergent cesarean delivery, including cesarean delivery for failure to progress with reassuring electronic fetal heart rate tracing 2. age greater than or equal to 18 years of age. 3. healthy women at equal to or greater than 36 weeks gestation undergoing non-emergency cesarean delivery 4. spinal or epidural anesthesia exclusion criteria: 1. emergency cesarian delivery 2. non-reassuring fetal heart rate tracing 3. less than 18 years of age 4. multiple gestation (twins, triplets) 5. presentation other than vertex or breech 6. less than 36 weeks of gestation 7. general anesthesia
immune thrombocytopenia (itp) immune-genetic assessment

Conditions: Thrombocytopenia

Summary: primary itp has wide heterogenous biology, presentation and response to therapy. the immune-genetic assessment of itp may help to identify differences among patients with itp and optimize the therapeutic choice.


Eligibility criteria:
inclusion criteria: * adult patients with primary itp exclusion criteria: * secondary itp

Keywords: patients with primary immune thrombocytopenia (itp)
leap2 kinetics in healthy individuals

Conditions: Obesity

Summary: the study aims to investigate the kinetics of the naturally occurring peptide liver-enriched antimicrobial peptide 2 (leap-2) in healthy volunteers. the overall objective is to investigate the physiological importance of leap-2 in healthy subjects.

in a recent study, the molecular phenotype of enteroendocrine cells in the small intestine before and after roux-en-y gastric bypass (rygb) surgery in obese individuals was examined. enteroendocrine cells were identified and isolated from intestinal biopsies and analysed for differentially expressed genes by illumina high throughput rna-sequencing. it was discovered that the gene encoding liver-enriched antimicrobial peptide 2 (leap2), a naturally occurring peptide in humans, was significantly upregulated compared to baseline expression. interestingly, leap2 was recently shown to antagonize ghrelin function in response to feeding in mice. moreover, the mature murine leap2 peptide is identical in mice and humans. thus, leap2 has been identified as an endogenous peptide that may be able to alter feeding behaviour and maintenance of glucose levels during calorie restriction. this study aims to investigate the kinetics of exogenous leap2 in healthy subjects.

Eligibility criteria:
inclusion criteria: * caucasian men * age between 18 and 25 years * body mass index between 20-35 kg/m2 * informed consent exclusion criteria: * anaemia (haemoglobin below normal range) * alanine aminotransferase (alat) and/or aspartate aminotransferase (asat) \>2 times normal values) or history of hepatobiliary and/or gastrointestinal disorder(s) * nephropathy (serum creatinine above normal range and/or albuminuria) * allergy or intolerance to ingredients included in the standardised meals * first-degree relatives with diabetes and/or glycated haemoglobin (hba1c) \>48 mmol/mol * regular tobacco smoking or use of other nicotine-containing products * any ongoing medication that the investigator evaluates would interfere with trial participation. * any physical or psychological condition that the investigator evaluates would interfere with trial participation including any acute or chronic illnesses
efficacy of "tailored physical activity" in health care workers

Conditions: Pain

Summary: the purpose of this study is to test the effect of "tailored physical activity" on the number of sick-days. the hypothesis is that "tailored physical activity" is superior in efficacy on sick-days.

health care workers have high prevalence of musculoskeletal pain. pain in the back and neck and other musculoskeletal disorders are the leading cause for long-term sick leave. this study test the effect of "tailored physical activity" on self-reported days on sick leave and parameters regarding pain, function and quality of life respectively on the body function and participation level of health care workers which have experienced musculoskeletal pain related to the back or upper body. a minimum of 44 health care workers in dk-sønderborg municipality will be randomized for "tailored physical activity" or a reference group. primary endpoint is 3 months and 12 months follow-up.

Eligibility criteria:
inclusion criteria: health care workers in municipality of sønderborg that have experienced musculoskeletal pain related to the spine or upper body. exclusion criteria: medically safety.

Keywords: health care workers tailored physical activity prevention spine upper body pain related to spine or upper body
a 12 week physical training programme for patients with chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the purpose of this study is to determine whether water based or land based group training is more effective for people with copd.

copd is a more common diagnosis today compared to 20 years ago, and the group is growing fast. the suffering caused by copd and the financial cost to society is on the increasing. the principal causes of copd are smoking and inactivity. so far it is poorly understood wich form of exercise is the most effective in training this condition.

Eligibility criteria:
inclusion criteria: * copd gold ii * not taking part in physical activity during the last year exclusion criteria: * copd gold i, iii, iv * pain in the legs that make activity difficult

Keywords: chronic obstructive pulmonary disease copd physical group training water exercise cardiorespiratory fitness functional exercise capacity health related quality of life
effects of kinesio taping in patellofemoral pain

Conditions: Patellofemoral Pain Syndrome

Summary: the study aims to analyze the immediate effects and 72 hours after application of the kinesio taping (kt) in the electromyographic activity of the vastus medialis oblique (vmo) and vastus lateralis (vl), the isokinetic performance of the quadriceps and referred pain of subjects with pfps. the volunteers will be randomly assigned to one of the three groups and perform one of the protocols: control - remain at rest; kt - application of kinesio taping with tension in the vmo region; placebo - application of kinesio taping without tension, in the same region. all volunteers will be submitted to the evaluation of pain intensity, the electromyographic activity of the vmo and vl and dynamometric parameters in 3 times: before the application of kt, immediately after the application of kt and after 72h of application. average effect estimates (differences between groups) for all variables will be calculated using the mixed model anova with a significance level of 5% (p ≤ 0.05).


Eligibility criteria:
inclusion criteria: * female between 18 and 35 years; * bmi below 30; * clinical diagnosis- previous pain or retropatellar in at least two of the following functional activities: stay for a long time sitting, up or down stairs, run, kneel, crouch, jump; * onset of symptoms insidiously and nontraumatic; * pain intensity 3 or more on eva; * presence of pain for at least 1 month; exclusion criteria: * be performing currently physiotherapy; * it present surgery, trauma or musculoskeletal system of the lower limb injury within 6 months; * there have other pathologies associated with the knee joint; * does not run the tests properly; * does not attend all assessments.

Keywords: electromyography torque quadriceps muscle
psychological intervention for misophonia

Conditions: Misophonia

Summary: the investigators are proposing to test acceptance and commitment therapy (act)+ traditional audiological behavioral intervention as an integrated, multi-disciplinary approach for the assessment and treatment of misophonia. participants will be 60 adults with misophonia and will be randomly assigned to receive 12 sessions of act+behavioral intervention or receive 12 weeks of progressive relaxation training+psychoeducation (prt; a commonly used active control condition) after undergoing a comprehensive psychological and audiological evaluation.

acceptance and commitment therapy (act) is a promising psychotherapy for supporting traditional behavioral methods for treating misophonia, but has not been previously tested. act teaches skills to develop acceptance, mindfulness, and defusion from difficult internal experiences while increasing connections with personal values and encouraging meaningful behavioral changes. this study will help determine if act+behavioral intervention is a feasible and acceptable treatment for misophonia, help clarify active psychological mechanisms of misophonia, and determine whether or not this combination of services can effectively help individuals diagnosed with misophonia.

Eligibility criteria:
inclusion criteria: * individuals seeking treatment for misophonia. * meet clinical cut-off for misphonia (minimum score of five on the misophonia questionnaire). * stable on psychotropic medication for at least 30 days. * english speaking. exclusion criteria: * presence of psychological and/or neurological impairments that would preclude someone from participating in the study or exceed misophonia as the primary presenting problem (e.g. active self-harm or need for treatment for psychosis).
recurindex guided avoidance of regional nodal irradiation for node positive breast cancer

Conditions: Breast Cancer; Radiation

Summary: the purpose of this study is to validate whether clinically low-risk, and recurindex high-risk n1 patients receiving regional lymph node radiotherapy can further improve clinical outcomes.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years old, ≤ 70 years old. * eastern cooperative oncology group (ecog) ≤ 2. * postoperative pathology is clearly diagnosed as invasive breast cancer. * meet the clinical definition of low risk: ①axillary lymph node micrometastasis (n1mic) or ②n1 patients who meet the following conditions at the same time, a）age ≥ 40 years old, b）vascular tumor thrombus (lvi) negative or allow few positive lvi (excluding extensive or massive lvi), c）three subtypes are allowed (lumina a, lumina b/her2 negative, lumina b/her2 positive) , namely er positive (er ≥ 1%), her2 negative (her2 expression negative or + by ihc, or 2+ but negative by fish) or er positive (er ≥ 1%), her2 positive (3+ by ihc, or 2+ but positive by fish). * postoperative pathological diagnosis of axillary lymph node status is any of the following: a. sentinel lymph node biopsy or axillary lymph node dissection for micrometastasis (n1mic), b. sentinel lymph node biopsy for 1-2 lymph node macrometastasis (n1sln), c. sentinel lymph node biopsy + axillary lymph node dissection or simple axillary lymph node dissection for 1-3 lymph node metastasis (n1). * the primary tumor and breast undergo breast-conserving surgery or total resection ± breast reconstruction (autologous/prosthetic). * there must be adequate systemic examination (such as chest x-ray, b-ultrasound, ct, etc.) within 3 months before randomization of radiotherapy to confirm that there is no distant metastasis. * no contralateral breast cancer must be confirmed by molybdenum target and/or mri within 12 months before randomization of radiotherapy. * at least 4 courses of adjuvant chemotherapy with anthracycline or taxane should be completed after surgery. * radiotherapy must be performed sequentially after the completion of adjuvant chemotherapy, starting no later than 8 weeks after the end of chemotherapy. * the patient must have sufficient primary fresh frozen specimens or post-paraffin tissue sections for recurindex testing. * no previous history of malignant tumors, except for basal cell carcinoma of the skin. * signed an informed consent form. exclusion criteria: * postoperative radiotherapy was confirmed as t3-4, n0, n2-3, m1 lesion staging before enrollment. * receive any new adjuvant therapy before surgery, including chemotherapy, endocrine therapy, targeted therapy or radiation therapy. * patients who underwent total mastectomy and only sentinel lymph node biopsy. * have a history of contralateral breast cancer. * history of chest radiotherapy. * combined with severe heart, lung, liver, kidney, hematopoietic, neurological diseases, and mental illness. * history of autoimmune diseases such as scleroderma or active lupus erythematosus. * pregnant and lactating patients. * unable or unwilling to sign an informed consent form.
effect of exercise given to factory workers with ergonomics training on pain and functionality

Conditions: Work-related Illness; Work Accident; Occupational Diseases

Summary: the aim of this study is to evaluate the effects of ergonomics training with exercises applied on factory workers with low back pain on pain, functionality, sleep and fatigue.

the study was planned as a randomized controlled trial. workers between the ages of 18 and 60 working in a plastic casting factory in gebze/kocaeli with back and low back pain will be included in the study. participants will be divided into two groups using a simple randomization method. ergonomics training will be given to the first group together with core stabilization exercises; the second group will be given only ergonomics training. the exercises they will do will be explained to the participants individually and will be supported by an exercise brochure. participants will be asked to do the given exercises 3 days a week and continue for 8 weeks. follow-up of the given exercises will be done with the exercise follow-up chart. persons with psychological or physical disabilities who can exercise regularly will not be included in the study. in order to collect data on the sociodemographic characteristics of the participants, a personal information form will be prepared by the researcher and the participants will be asked to fill in this form. in order to collect data from the participants; "mcgill pain questionnaire (short)" and "visual analog scale" to collect information on pain; "fatigue severity scale" will be used to determine fatigue levels, "pittsburgh sleep quality questionnaire" will be used to determine sleep quality, and "oswestry low back pain scale" will be used to evaluate functionality. the questionnaires will be repeated before and after the study. the data before and after the intervention will be analyzed statistically.

Eligibility criteria:
inclusion criteria: * be between the ages of 18-65, * having low back pain in the last 3 months * visual pain scale (vas) \>4 * no surgical intervention in the last 6 months, exclusion criteria: * not being cooperative desk work * presence of psychological problems, * using sleeping pills * presence of neurological and orthopedic disease.

Keywords: workers pain exercise ergonomics functionality
phototoxic doses of ultraviolet a for treatment of alopecia areata

Conditions: Alopecia Areata

Summary: alopecia areata (aa) is a disease of the hair follicles with multifactorial etiology and a strong component of autoimmune origin. it is characterized by non-scarring hair loss on the scalp or any hair-bearing surface. various therapeutic agents have been described for the treatment of aa, but none are curative or preventive. the aim of aa treatment is to suppress the activity of the disease. phototherapy in the form of topical psoralen and ultraviolet a (puva) has been a well documented therapy for aa since 1978. a more recent technique of topical puva, namely phototoxic puva, has been adopted in two previous studies. sessions were carried out once every 3 months, and a higher efficacy with more encouraging response rates in comparison to the conventional puva therapy has been documented. this assumed upper hand over the conventional puva might be due to increasing the amount of uv reaching the hair follicle cells and the surrounding inflammatory cells. also it has been suggested that it might play a role as a powerful initiating agent of suppression through direct action at the dna level. however, still the exact effect of this treatment has not been fully clarified.


Eligibility criteria:
inclusion criteria: * patients presenting with alopecia areata, patchy type (max 3 patches not exceeding 50% of the scalp surface area) of more than 2 months duration. * age: 12 years and above exclusion criteria: * age: less than 12 years old. * affection of more than 50% of the scalp area * diagnosis or history of local dermatological disease in the scalp apart from aa such as eczema, seborrheic dermatitis, psoriasis,.. * any present / past history of dermatological disease with a potential for koebnerization such as psoriasis, vitiligo. * diagnosis or history of any contraindication to receiving phototherapy such as malignancy, systemic lupus * dermoscopic evaluation revealing absence of any signs of presence of hair follicles. * any psychiatric illness or psychological state impairing future compliance or influencing expectations of the patient. * patients with aa totalis or ophiasis

Keywords: alopecia areata phototherapy phototoxic ultraviolet a randomized controlled trial interferon gamma transforming growth factor beta-1 insulin like growth factor-1