Kornimate/medical-research-clean huggingface dataset:
proton therapy with chemotherapy for stage iii non-small cell lung cancer (lu02)

Conditions: Non-Small Cell Lung Cancer

Summary: the purpose of this study is to find out what effects, good and/or bad, proton radiation at a higher tumor dose (and lower normal surrounding lung dose) combined with standard chemotherapy has on lung cancer. the dose you receive to the tumor will be higher than the standard dose. this may be able to increase the control of the tumor. due to the accuracy of radiation given with protons, the dose to the normal lung tissue that surrounds the tumor will be lower than standard. this may be able to reduce the frequency and severity of the usual radiation side effects.


Eligibility criteria:
inclusion criteria: * histologically or cytologically documented non-small cell carcinoma of the lung diagnosed within 16 weeks prior to study enrollment. * patient must be at least 18 years old at the time of consent. * stage iii a or iii b disease. * patients must be able to start study treatment within 6 weeks of study enrollment. * induction chemotherapy is allowed. * marginally resectable or unresectable at presentation. * if the patient had exploratory thoracotomy, it must be done at least 3 weeks prior to enrollment. exclusion criteria: * evidence of distant metastasis. * prior thoracic radiotherapy. * any history of allergic reaction to taxanes. * prior tumor resection. candidate for upfront curative surgery. * pleural effusion visible on chest x-ray or the scout view of the ct chest. * unintentional weight loss within the month prior to diagnosis ≥ 10%. * previous or concomitant malignancy other than early stage tumor treated more than 3 years ago for cure. * the presence of pet positive contralateral hilar disease.

Keywords: non-small cell lung cancer proton radiation stage iii
textfluenza: using technology to promote flu vaccination in underserved maternal and child populations

Conditions: Influenza

Summary: the advisory committee on immunization practices (acip)recommends that the flu vaccine be administered annually to all children aged 6 months to 18 years as well as women who are pregnant during the influenza season. nevertheless, targeting and mobilizing these populations has been difficult and influenza immunization rates nationwide remain low. immunization reminder-recalls have been shown to be effective, but have had limited ability to rapidly identify and reach large target populations in a cost-effective manner. evidence on how to optimally design these systems is not yet available and thus text message immunization alerts have not been widely implemented. the investigators propose to implement and evaluate tailored, targeted influenza text message reminders in urban pediatric and pregnant populations.


Eligibility criteria:
inclusion criteria parents (2010-2011 and 2011-2012 influenza seasons) * children aged 6 months to 18 years at the beginning of current influenza season * children with one previous visit at participating pediatric community health center in last year * parent with cell phone number in registry pregnant women pilot (2010-2011 influenza seasons) * pregnant women who will be in their 2nd or 3rd trimester during the influenza season * own a cell phone with text message capability randomized controlled trial (2011-2012 influenza seasons) * pregnant and will be in their 2nd or 3rd trimester during the influenza season * cell phone number in registry

Keywords: influenza, text message, vaccination
alcohol use disorders (auds) and post-traumatic stress disorder (ptsd) treatment for victims of partner violence

Conditions: PTSD; Substance Use Disorders

Summary: the goal of this study is to evaluate a psychotherapy for ptsd and substance use disorders among women who have experienced domestic violence. the hypothesis is that women who receive present-focused, integrated treatment will have greater ptsd symptom reduction and have less substance use after treatment than women in the control condition who will receive supportive therapy based on a 12-step approach.

the goal of this study is to evaluate an integrated psychotherapy for ptsd and substance use disorders among female victims of intimate partner violence. the hypothesis is that women who receive present-focused, integrated treatment will have greater ptsd symptom reduction and have less substance use post-treatment than women in the control condition who will receive supportive therapy based on a 12-step approach.

Eligibility criteria:
inclusion criteria: * female victims of partner violence * at least one month out of the abusive relationship * meet dsm-iv (american psychiatric association, 1994) criteria for ptsd and an alcohol use disorder * literate in english * have not changed psychotropic medications or dosages within the past two months and agree not to during the active phase (first 12 weeks) of the intervention * have an identified primary care physician exclusion criteria: * moderate or severe cognitive impairment as measured by a mini-mental state examination score less than or equal to 18 * histories of psychosis or mania may be excluded because the presence of these disorders is thought to impede progress in psychotherapy

Keywords: ptsd substance use disorders psychotherapy
dose reduction of preoperative radiotherapy in myxoid liposarcomas

Conditions: Myxoid Liposarcoma of Soft Tissue

Summary: to study the feasibility of reducing the dose of preoperative radiotherapy in mls (myxoid liposarcomas) from 50 gy to 36 gy while maintaining comparable clinicopathological responses.

* a bayesian approach is considered for the analysis of this trial. the aim is to provide a stopping rule for inefficacy of the new dose. * two aspects are important to elucidate the mechanism of this treatment: dynamic investigations of perfusion and vasculature. apart from participation to the dose reduction paragraphs of this study, patients will be also asked to undergo, at clinically relevant dose points, dynamic contrast enhanced (dec) mri scans and separately tumor biopsies.

Eligibility criteria:
inclusion criteria: 1. age above or equal to 18 years 2. biopsy proven mls (including the reciprocal chromosomal translocation t(12;16)(q13;p11); a the primary sarcoma in case of non-metastatic disease for management is with curative intent (regimen to be chosen = 18 x 2 gy) b in case of oligometastatic patients, the metastasis may also be irradiated to a dose of 36 gy in order to postpone the time interval to next systemic chemotherapy. these patients are usually not operated upon and the total dose may also be reached in 12 times 3 gy, for convenience purposes (see paragraph 10 for radiobiological considerations). 3. ecog (eastern cooperative oncology group) ps (performance status) 0-2 4. patients must be able (physically, mentally and socially) to complete a series of rt, followed by an observation period of 4-6 weeks and undergo surgery. 5. written informed consent exclusion criteria: 1. prior radiotherapy to the target area. 2. anticoagulant medication of any kind; especially ascal®(and derivates), coumarines (sintrom® and marcoumar®), all heparin and heparin-like formulations. (note: this exclusion criterion only applies for patients consenting to the translational research part of the study; patients on anticoagulant medication as described above may take part in the dose reduction part of the study, but the repeat biopsies may not be taken.) 3. pregnancy -

Keywords: radiotherapy myxoid liposarcoma soft tissue sarcoma
phosphodiesterase 4 gene variant and salbutamol response in persistent childhood asthma

Conditions: Asthma

Summary: this study is designed to investigate whether the phosphodiesterase 4 gene variability could be implicated in the salbutamol responsiveness in asthmatic children.

patients from 6 to 18 years old with asthma and receiving a treatment by salbutamol according to the usual care will be recruited. saliva from patients will be collected using oragen®.dna og-575 kit.

Eligibility criteria:
inclusion criteria: * children 6-18 years * asthma: confirmed asthma symptoms (wheeze, cough, dyspnea, chest tightness) and evidence for variable airflow limitation (≥ 12% increase in post bronchodilator fev1, or ≥ 20% decrease in fev1 post methacholine) * spirometry prescribed for follow-up * airflow limitation: fev1\<80% and/or fev1/fvc \<80 pre-bronchodilator exclusion criteria: * no exclusion criteria

Keywords: asthma salbutamol response phosphodiesterase 4 variant lung function airflow limitation
investigating the clinical and cost effectiveness of lycra splinting

Conditions: Learning Disability

Summary: people with learning disabilities (lds) experience high levels of health problems, including cerebral palsy, other problems associated with posture, movement and function, and injury (falls are the commonest cause of injury in this population, and poor balance/coordination are a contributory factor). the aim of this project is to investigate the clinical and cost effectiveness of lycra splinting garments (lsgs), worn to improve posture, movement and function, for adults (16 years and over) with lds who fall. this project aims to investigate the clinical and cost effectiveness of lsgs to prevent future falls of adults with lds, to inform practice and guidelines within local and national (national health service - nhs) adult services. falls and fall injury are a serious problem for people with lds (people with lds experience similar rates of falls as the elderly in the general population but at a younger age), whereby interventions are warranted. lab based 3d movement analysis will be conducted with adults with lds who fall during two visits to perform simple tasks (e.g. walking) (once prior to being provided with lsg, and once 6 weeks after wearing the lsgs at home).

adults with learning disability who have capacity will be recruited to participate in the lycra splinting trial via their local physiotherapist. the eligibility criteria is an adult with learning disability who has had a fall and who has problems with their balance and/or gait as identified by their local physiotherapist. the participants will be recruited via participant information sheets. the participants will attend the glasgow caledonian university (gcu) gait laboratory to undertake three-dimensional movement analysis; gaitrite test (the gaitrite is a commercially available instrumented walkway); and centre of pressure testing. this will take place before prescription of a lycra splinting garment and a minimum of 6 weeks wear after receiving a lycra splinting garment. analysis of data captured before and after wearing the lycra splinting garment will take place. the use-ability of the lycra splinting garment will also be determined by completion of a user and carer questionnaire and by completion of a questionnaire by their local physiotherapist. the cost effectiveness of lycra splinting garments will be analysed by a health statistician within gcu.

Eligibility criteria:
inclusion criteria: * participant has a learning disability, and has had a fall within the last 12 months due to a balance or gait issue. exclusion criteria: * any participant who does not have capacity to consent.

Keywords: falls
laparoscopic supracervical hysterectomy versus total laparoscopic hysterectomy

Conditions: Gynecologic Diseases

Summary: the purpose of this research study is to evaluate whether there is any difference in recovery time and return to normal activities following a laparoscopic supracervical hysterectomy (lsh) compared with total laparoscopic hysterectomy (tlh). both types of hysterectomies are commonly performed at our institution. patients will be assigned by chance (like a coin toss) to have either a lsh or a tlh. preoperatively, participants will complete a quality of life questionnaire (sf-36), a sexual function questionnaire (fsfi)and a 3 question questionnaire about urinary function (3iq). following surgery participants will be asked to keep a diary of pain symptoms and use of narcotics. the diary will be filled out daily until patients have resumed normal activities from prior to the surgery. the sf-36 will be completed again 6 weeks following the original surgery. 6 months following surgery participants will receive a copy of the sf-36 and the fsfi in the mail. they will also be asked questions about urinary symptoms and persistent vaginal bleeding.


Eligibility criteria:
inclusion criteria: * candidates for laparoscopic hysterectomy for benign indications exclusion criteria: * malignancy of the uterus, cervix or adnexa * pre-malignant changes of the uterus, cervix or adnexa * history of severe cervical dysplasia (cin ii or above)

Keywords: hysterectomy laparoscopic
biomarkers of brain injury in critically-ill children on extracorporeal membrane oxygenation

Conditions: Extracorporeal Membrane Oxygenation; Children; Neurologic Injury

Summary: the beam study is a multicenter, prospective, observational study in children supported on extracorporeal membrane oxygenation (ecmo). the primary goals of this study are to develop and refine a brain injury multimarker panel for accurate neurologic monitoring at the bedside and early classification of mortality and disability outcomes of critically ill children supported on ecmo.

the specific aims are to: 1. determine if circulating levels of brain injury markers during ecmo and brain mri abnormalities within 6 weeks after ecmo are associated with survival at 18 months after ecmo with a score ≥85 on the vineland adaptive behavior scales, third edition (vabs-iii). 2. determine whether the presence and degree of inflammation during ecmo and markers of neuroinflammation on brain magnetic resonance spectroscopy (mrs) within 6 weeks after ecmo are associated with survival at 18 months after ecmo with a score ≥85 on vabs-iii. 3. determine whether metabolic and lipid neuroinflammatory pathways will distinguish between at-risk for, acute, and recovery phases of neurologic injury (ni) during ecmo.

Eligibility criteria:
inclusion criteria: * children (2 days to \<18 years) cannulated onto ecmo and admitted to a pediatric or cardiac intensive care unit at participating institutions. exclusion criteria: * ecmo cannulation at an outside institution with transport to a study site \>24 hours after ecmo initiation * limitation of care (e.g., family planning to withdraw support) * brain death evaluation within 24 hours of ecmo cannulation * inability to speak or understand english or spanish * pregnancy.

Keywords: brain injury biomarkers neurodevelopmental outcomes
pulmonary ultrasound for the assessment of atelectasis in anesthetized children using a laryngeal mask airway.

Conditions: Atelectasis; Hypoxemia

Summary: this study will use lung ultrasounds (lus) to evaluate the incidence and severity of intraoperative atelectasis in anesthetized children undergoing minor surgery using a laryngeal mask airway. the children will be randomly assigned to be left in spontaneous ventilation with a positive end expiratory pressure (peep) of 5cmh2o or to be ventilated with a pressure support mode.

it is well known and described the deleterious effect that general anesthesia (ga) has on functional residual capacity (frc), especially in children. this population is at higher risk of decreasing frc during ga because of their lower capacity for elastic retraction and lower relaxation volume comparing to adults, predisposing them to the development of atelectasis and airway closure. these factors will lead to intrapulmonary shunts, which may impair the gas exchange and consequently oxygenation. by reducing the intrapulmonary shunt, positive end expiratory pressure (peep) during controlled mechanical ventilation in patients with healthy lungs optimizes the frc. however, the available data for an optimal ventilation strategy, including optimal peep, using a laryngeal mask airway (lma) in the pediatric population are scarce, even though this device is frequently used in all age groups for brief general anesthesia. diagnosing anesthesia-induced atelectasis in the perioperative period can be possible by using lung ultrasounds (lus), a simple, easily accessible, non-invasive and radiation free technique, which might help determine the impact in pulmonary aeration between different ventilation strategies. in our study, we will focus on comparing spontaneous ventilation (vs) with a peep of 5 cmh2o and pressure-support ventilation using a lma in anesthetized children undergoing minor and elective outpatient surgery.

Eligibility criteria:
inclusion criteria: * fasted children between 12 months and 8 years of age; american society of anesthesiology (asa) score i or ii without lung disease; baseline pulse oximetry in room air \>96%; scheduled for minor urological surgery (circumcision) under general anesthesia; written parent's agreement. exclusion criteria: * asa score \> ii, chronic lung disease, airway infection in the last 15 days, impossibility of insertion of lma.

Keywords: lung ultrasounds laryngeal mask airway anesthetized children spontaneous ventilation pressure support ventilation positive end expiratory pressure
serum il-17 correlated with inflammatory changes in osteoarthritis and rheumatoid arthritis

Conditions: Rheumatoid Arthritis (RA) and Osteoarthritis (OA)

Summary: the total number of the included subjects was 120 in 3 equal groups (ra, oa and control). all subject was subjected to serum il17 level measurement. msk us (of both wrists, mcps, pips and dips) was done to all patients in ra and oa groups. disease activity was measured by disease activity score (das28) for ra patients. visual analogue scale for pain (vas) was obtained from patients in ra and oa groups. functional assessment was done using health assessment questionnaire (haq) for ra patients and the australian/canadian (auscan) osteoarthritis hand index for oa patients


Eligibility criteria:
inclusion criteria: * a patient is considered having definite ra if he/she scores at least 6 points in the established classification system * a patient is considered having hand oa if he /she hand pain, aching, or stiffness plus 3 or 4 of hard tissue enlargement of 2 or more of 10 selected joints or hard tissue enlargement of 2 or more dip joints or fewer than 3 swollen mcp joints, or deformity of at least 1 of 10 selected joints which are are the second and third distal interphalangeal (dip), the second and third proximal interphalangeal, and the first carpometacarpal joints of both hands exclusion criteria: * any subject with liver diseases, coronary artery diseases, kidney diseases or other inflammatory conditions was excluded from the study.
cost information on carpal tunnel syndrome treatment decisions

Conditions: Carpal Tunnel Syndrome

Summary: the purpose of this study was to determine whether the provision of societal cost information affects patients' decisions whether or not to undergo surgical management in carpal tunnel syndrome, using a hypothetical scenario.

given the large societal costs of carpal tunnel surgery and existence of a relatively inexpensive treatment option, carpal tunnel release provides fertile ground for testing whether societal costs can influence patient decision-making in hand surgery. such work would inform future efforts to reduce societal healthcare costs by elucidating whether appeals to societal cost are effective at driving stewardship of limited healthcare resources at the patient level. in this study, the investigators aimed to answer this question by presenting participants with a hypothetical scenario in which the participants had to choose between surgery and wrist bracing for carpal tunnel syndrome. participants were randomized into two cohorts and societal cost information was presented to the intervention group. the effect of societal cost information on treatment choice is assessed, along with participants' healthcare attitudes.

Eligibility criteria:
inclusion criteria: * english speaking upper extremity patients * nontraumatic condition exclusion criteria: * traumatic condition
inflammation and daily life study

Conditions: Inflammation

Summary: ucla researchers looking for healthy individuals (age 45-60) to participate in a study investigating whether an anti-inflammatory medication can impact daily life experiences. everyday for two weeks, participants will take either an anti-inflammatory medication (naproxen) twice daily, or a placebo pill twice daily. participants will also answer daily questions during the 2-week period. participants will also fill out questionnaires and complete a few tasks on the computer: once prior to the 2-week period and once immediately after the 2-week period, both during online study sessions.

participants (ntotal=50) will be men and women, ages 45-60. all interested participants will first complete a structured telephone interview in order to assess eligibility. the study will begin with filling out questionnaires, as well as an online session to complete some tasks. you will then be randomly assigned to take either an anti-inflammatory medication (naproxen) or placebo (inactive substance) to take twice daily everyday for the following two weeks. you will also be contacted by text message to remind you to take your pills, to ask if you have taken your pills, and to send you a link to fill out questionnaires once daily. after the two weeks are over, you will again complete questionnaires and the online study session with tasks. finally, two weeks after the second session, you will receive an email to fill out questionnaires online.

Eligibility criteria:
inclusion criteria: * healthy adults 45-60 exclusion criteria: following a structured telephone interview, participants with the following conditions will not be able to participate: * certain active, uncontrolled medical disorders * use of certain medications (e.g., hypnotic and psychotropic medication, steroid use, opioid use) * psychiatric disorders (e.g., current major depression, bipolar disorder) other exclusion criteria may apply.

Keywords: immune system social psychology health psychology