Kornimate/medical-research-clean huggingface dataset:
the alighieri survey: an italian overview of global impact of the covid-19 pandemic on general surgery practice

Conditions: Surgery and covid19

Summary: introduction the present survey aimed to provide a comprehensive overview of the italian scenario concerning general surgery during the first wave covid-19 outbreak and evaluate the experiences, trends, attitudes, and possible educational outcomes that this emergency brought to light. material and methods a 31-item survey was designed and edited by the scientific board of the acoi (associazione chirurghi ospedalieri italiani), addressing the impact of the pandemic outbreak on surgical staff and activity during the period from march 9 to may 30, 2020 (phase 1, lockdown period) and addressing the status of surgical activity, staff, and surgery resumption in the period from june 1 to september 30, 2020 (phase 3, restart). the survey was distributed via email and social media to italian general surgeon working both in covid-19 and non-covid-19 hospitals. r

introduction the present survey aimed to provide a comprehensive overview of the italian scenario concerning general surgery during the first wave covid-19 outbreak and evaluate the experiences, trends, attitudes, and possible educational outcomes that this emergency brought to light. material and methods a 31-item survey was designed and edited by the scientific board of the acoi (associazione chirurghi ospedalieri italiani), addressing the impact of the pandemic outbreak on surgical staff and activity during the period from march 9 to may 30, 2020 (phase 1, lockdown period) and addressing the status of surgical activity, staff, and surgery resumption in the period from june 1 to september 30, 2020 (phase 3, restart). the survey was distributed via email and social media to italian general surgeon working both in covid-19 and non-covid-19 hospitals. .

Eligibility criteria:
inclusion criteria: * alla surgeon in activity exclusion criteria: * none
safety and efficacy of probuphine in the treatment of opioid dependence

Conditions: Opioid Dependence

Summary: buprenorphine (bpn) is an approved treatment for opioid dependence, however, in taking oral tablets, patients experience withdrawal and cravings when the variable bpn levels in the blood are low. probuphine is an implant placed just beneath the skin that contains bpn. it is designed to provide 6 months of stable bpn blood levels. this study will test the safety and efficacy of probuphine in the treatment of patients with opioid dependence.


Eligibility criteria:
inclusion criteria: * voluntarily provide written informed consent prior to the conduct of any study related procedures * male or female, 18-65 years of age * meet dsm-iv criteria for current opioid dependence * females of childbearing potential and fertile males must use a reliable means of contraception exclusion criteria: * current diagnosis of acquired immune deficiency syndrome (aids) * presence of aspartate aminotransferase (ast) levels ≥ 3 x upper limit of normal and/or alanine aminotransferase (alt) levels ≥ 3 x upper limit of normal and/or total bilirubin ≥ 1.5 x upper limit of normal and/or creatinine ≥ 1.5 x upper limit of normal * received treatment for opioid dependence (e.g., methadone, bpn), within the previous 90 days * current diagnosis of chronic pain requiring opioids for treatment * candidates for only short term opioid treatment or opioid detoxification therapy * pregnant or lactating females * previous hypersensitivity or allergy to bpn- or eva-containing substances or naloxone * current use of agents metabolized through cyp 3a4 such as azole antifungals (e.g., ketoconazole), macrolide antibiotics (e.g., erythromycin), and protease inhibitors (e.g., ritonavir, indinavir, and saquinavir) * current anti-coagulant therapy (such as warfarin) or an inr \> 1.2 * meet dsm-iv criteria for current dependence on any other psychoactive substances other than opioids or nicotine (e.g., alcohol, sedatives) * current use of benzodiazepines other than physician prescribed use * significant medical or psychiatric symptoms or dementia which in the opinion of the investigators would preclude compliance with the protocol, patient safety, adequate cooperation in the study, or obtaining informed consent * concurrent medical conditions (such as severe respiratory insufficiency) that may prevent the patient from safely participating in study; and/or any pending legal action that could prohibit participation and/or compliance in study * participated in a clinical study within the previous 8 weeks

Keywords: opioid dependence opioid addiction buprenorphine methadone heroin implant opioid withdrawal opioid pain medication suboxone
evaluation of a treadmill workstation in an emergency dispatch center

Conditions: Work-Related Condition

Summary: the principal objective of this study is to determine if the provision of a treadmill workstation in an emergency medical services (ems) dispatch center increases the number of steps that participants make daily within 6 months compared to the usual working conditions. the investigators hypothesized that the provision of a treadmill workstation with a slow walking could increase the number of daily steps and decrease days of leave, musculoskeletal disorders without decreasing the dispatch quality.

sedentariness, measured by the daily duration of time spent seated is a cardiovascular risk factor, chronic pathologies (cancer, musculoskeletal pain) and mortality. the employees who remain seated from 8 to 11 hours per day have an increase risk of death within 3 years (15%). this increase reaches 40% for more than 11 hours a day. the restoration of a daily moderate physical activity from 60 to 75 minutes could permit to eliminate this increased risk. interventions in workplace to limit sitting are associated with a metabolic benefit, but also with a reduction in musculoskeletal problems and fatigue. the role of dispatchers is to initiate the medical record by determining the severity of the call and take rapid and adequate decision. they are seated behind their desks from 8 to 11 hours in a busy and stressful environment. many dispatchers are complaining of musculoskeletal disorders and weight gain. an internal study conducted between between 2012 and 2016 showed an increase in long-term pain, irritability and sleep disorders. overall, 65% of the respondents reported that they were tired at work and had less empathy. the use of workstations with low-speed treadmills were assessed to allow physical activity at work. a recent review concluded that their use reduced the time that the employees spent seated, stress and improved energy expenditure, as well as different biological and physical parameters (weight loss, lipid determination, glycaemia). this study did not reveal any alterations in performance at work. the investigators assume that the establishment of a position allowing slow walk during dispatch call would increase the number of steps made by dispatchers on a daily basis and reduce the number of days of leave and musculoskeletal disorders, without impairing the quality of call pick-up.

Eligibility criteria:
inclusion criteria: * dispatchers working in emergency medical service exclusion criteria: * pregnant women * inability to walk

Keywords: treadmills exercise number of steps dispatchers
association between basal proteinuria levels and pregnancy outcomes in familial mediterranean fever

Conditions: Basal Proteinuria in Pregnancy

Summary: to investigate the effect of basal proteinuria on pregnancy outcomes of patients with familial mediterranean fever (fmf).

familial mediterranean fever (fmf) is also known recurrent polyserositis the most common hereditary recurrent febrile disorder. it is characterized by paroxysmal episodes of the high fever and signs of serositis-peritonitis, pleuritis, synovitis. between these attacks, patients are usually asymptomatic. fmf mainly affects populations of the mediterranean region such as turks. the diagnosis of fmf may be extremely difficult to establish in the presence of atypical signs, and absence of family history . colchicine is effective in most of the patients with fmf. the one the most important complications of fmf is the development of renal amyloidosis. it potentially progress sequentially through preclinical, proteinuric, nephrotic, azotemic and uremic stages to end stage renal disease if not treated properly with colchicine. previous studies suggests that colchicine does not appear to be a major human teratogen, and, probably, has no cytogenetic effect. fmf affects females mainly in their childbearing years. fmf is associated with higher rates of recurrent abortion, premature rupture of membranes (prom) and preterm birth. despite of adverse outcomes have been reported in pregnants with fmf the outcome of pregnancies in fmf appear favorable with the healthy population since the usingof the colchicine. although the effect of pregnancy on the course of fmf related amyloidosis is controversial, it is generally accepted that renal function may disrupt during pregnancy. few studies have investigated the effect of fmf complications (amyloidosis and nephrotic syndrome) on pregnancy course. the aim of this study is to investigate the effect of basal proteinuria on pregnancy outcome of patients with familial mediterranean fever (fmf).

Eligibility criteria:
inclusion criteria: * pregnant patients with fmf exclusion criteria: * multiple pregnancies

Keywords: basal proteinuria fmf pregnancy
genetic determinants of opioids analgesia

Conditions: Nephrolithiasis

Summary: the response to opioids varies greatly among individuals. some of these variability is accounted for by genetic factors. the present study was designed to evaluate the possibility that genetic polymorphism in the gene encoding for mu opioid receptor may explain variability in the response to alfentanil during lithotripsy.


Eligibility criteria:
inclusion criteria: * age \> 20 exclusion criteria: * regular use of opioid drugs * known hypersensitivity to alfentanil
crisis response planning for military personnel

Conditions: Suicidal; Suicide Threat; Suicidal Ideation

Summary: the study is a randomized trial comparing outcomes of active duty service members who present to the emergency department at risk for suicide and receive care from providers trained in crisis response planning versus those providing treatment as usual.


Eligibility criteria:
inclusion criteria: * active duty service members * \>18 years old * present to the emergency department at nmcsd with a primary concern related to suicidal ideation, plan, intention, or attempt, or are assessed as being at elevated risk of suicidal behavior * able to understand and speak english * able to provide consent exclusion criteria: * unable to provide informed consent due to impaired mental status (e.g., acute intoxication, psychosis, mania, altered consciousness)
effects of deep neck flexor and extensor exercises

Conditions: Mechanical Neck Pain

Summary: deep cervical flexor and extensor muscles show decreased strength in patients with mechanical neck pain. exercises involving deep cervical muscles has improved coordination and motor control. this study aim to determine the effects of deep flexor muscle exercises along with deep extensor muscle exercises on pain, range of motion and muscle strength in mechanical neck pain.

this study will be a randomized controlled trial and will be conducted in riphah rehabilitation clinic lahore and physiotherapy outpatient department of wapda teaching hospital lahore. non-probability consecutive sampling will be used to collect the data. sample size of 36 subjects with age group between 18-40 years will be taken. data will be collected from the patients having present complaint of mechanical neck pain. outcome measures will be taken using numeric pain rating scale (nprs) for pain, manual muscle testing (mmt) for muscle strength and universal goniometer (gu) for range of motion. an informed consent will be taken. subjects will be selected on the basis of inclusion and exclusion criteria and will be equally divided into two groups by random number generator table. both the groups will receive hot pack, superficial neck muscles stretching and neck isometrics, while group a will receive deep neck flexor and extensor exercises, and group b will receive conventional treatment. outcome measures will be measured at baseline and after 4 weeks. data analysis will be done by spss version 25.

Eligibility criteria:
inclusion criteria: * males and females * 18 and 40 years of age * forward head posture * manual muscle testing (mmt) grade less than 6 * deep flexor strength measured by pressure biofeedback unit (20 mmhg), patients who cannot hold craniocervical flexion (indicating yes) for 10 seconds exclusion criteria: * cervical radiculopathy * history of whiplash injury * history of cervical and thoracic spine surgery * neck pain associated with vertigo * history of spinal osteoporosis * vertebral fractures * tumors * diagnosed psychological disorders

Keywords: neck muscles neck pain muscle strength range of motion
pain management for cystoscopy: a prospective randomized study focused on understanding the role of the "bag squeeze" to manage pain for patients undergoing cystoscopy

Conditions: Pain, Procedural

Summary: the purpose of this study is to determine whether utilization of the "bag squeeze" technique during flexible cystoscopy changes pain scores using a study questionnaire designed by the team which comprises a validated lingard pain rating scale.


Eligibility criteria:
inclusion criteria: * male * undergoing flexible cystocopy at university health network that have undergone a flexible cystocopy and did not demonstrate difficulty during exploration (meatal stenosis or urethral stricture), simultaneous removal or ureteral stents or bladder biopsies or have a chronic history of pelvic pain exclusion criteria: - patients that do not meet the inclusion criteria.
to evaluate the immunogenicity and safety of inactivated hepatitis a vaccine

Conditions: Hepatitis A Vaccine

Summary: the purpose of this study is to evaluate the immunogenicity and safety after one primary dose and one additional dose of inactivated hepatitis a vaccine are administered in korean healthy children aged 12-23 months.

the objective of this study is to evaluate the immunogenicity and safety after one primary dose and one additional dose (administered twice in total at an interval of 6 months) of inactivated hepatitis a vaccine are administered in korean healthy children aged 12-23 months. for this, a two-group comparison study will be conducted using a previously approved inactivated hepatitis a vaccine (havrix inj., manufactured by gsk) as the control vaccine to prove that the immunogenicity of the test vaccine treatment group is not inferior to the control vaccine treatment group and to statistically confirm that there is no difference in safety.

Eligibility criteria:
inclusion criteria: * a child whose parents or representative provided written consent * a korean child aged 12-23 months on the day of the first vaccination * no history of hepatitis a or a having hepatitis a vaccination * a child who was determined by the investigator that there is no problem with the participation in the clinical study according to the medical history and physical examination results exclusion criteria: * tympanic temperature of 38℃ or above within 48 hours prior to the vaccination or on the day of vaccination * moderate to severe acute or chronic infectious disease on the day of vaccination * history of sensitivity to the following drugs: neomycin, formaldehyde, gentamicin sulfate, any preventive vaccines * disorders in the immune system, or congenital or acquired immunodeficient diseases * received immunosuppressive dose of systemic corticosteroids therapy within 12weeks days before vaccination * a child with uncontrolled epilepsy or neurological disorders * planned with other vaccine within 4 weeks after the vaccination date * administered with other vaccine within 4 weeks prior to the vaccination date * used immunoglobulin formulation or human plasma, or received a transfusion within 12 weeks prior to the vaccination date * a child who has participated or is participating in another clinical trial within 12 weeks prior to the vaccination date(systemic corticosteroids administered at doses corresponding to ≤0.5 mg/kg/day of prednisolone for 14 consecutive days or less is exceptionally allowed) * other reasons not specified above that, in the opinion of the investigator, may make the subject ineligible to participate in the study

Keywords: hepatitis a vaccine
back pain prevention in multiple myeloma using an external spinal brace

Conditions: Multiple Myeloma

Summary: consenting patients with multiple myeloma (mm) will be randomly allocated to receive either standard medical treatment (chemotherapy, radiotherapy, pain-killing medication) alone or standard medical treatment plus a brace. patients will be regularly evaluated in research clinics; the results data will inform the design of a full trial. information will be collected to inform a list of requirements a centre needs to have in place to run an rct of these interventions.

multiple myeloma (mm) is a neoplasia of plasma cells mostly within the bone marrow, commonly leading to multiple vertebral collapses. this causes spinal deformity, leading to incapacitating back pain and reduced quality of life. in spite of advances in medical therapy, some patients are left with disabling back pain, sometimes requiring surgical intervention. university hospitals of north midlands nhs trust have observed on an audit of our own practice that application of an external spinal brace as early in the disease process as is possible appears to maintain the overall alignment of the spine, thus minimising risk of spinal deformity and consequent back pain. the ultimate aim is to undertake an rct to determine whether the use of an external spinal brace can reduce back pain and spine-related disability in patients suffering from back pain due to multiple myeloma, in comparison to conventional management without a brace. however, prior to this, a feasibility study is required. the feasibility study is needed to see if the trial processes (providing patient information, consent process, conducting the baseline investigations and outcome measures) can be accommodated without causing too much delay to the application of the brace. suitable patients will be consented by the research team and randomised to receive a brace or no brace in addition to their routine myeloma treatment. after baseline data collection and questionnaires, the participant would be followed up for data collection at 6 weeks and 3 months.

Eligibility criteria:
inclusion criteria: * adults with mm * myeloma infiltration in the spine confirmed by radiological evidence * mm-related back pain * can attend for the whole follow up period exclusion criteria: * presenting with cord compression and neurological deficit requiring urgent decompression and intervention * chronic pain syndrome * language barrier that cannot be overcome using translation services * unwilling or unable to give informed consent * painful vcfs at the lumbosacral junction, l4 to sacrum, where application of brace is not possible. not suitable for treatment with a brace e.g. pregnancy
effect of ondansetron for withdrawal symptoms

Conditions: Substance Withdrawal Syndrome

Summary: we hope to determine whether ondansetron, an anti-nausea medication, works to help relieve withdrawal symptoms experienced while the patient is being weaned off opioid medications. this medication has shown anecdotal evidence of being affective for the treatment of withdrawal symptoms and we hope to determine whether this is affective.


Eligibility criteria:
inclusion criteria:-over 18 years of age * no medical contraindications to medication * able to fulfill research procedures exclusion criteria:-subjects who are unable to respond to our questionnaires or to stimuli as required by the experimental protocol will be excluded. * subjects will be excluded if they have a history of significant psychiatric disorders that would prevent them from engaging in a treatment program. * participating in other studies that would interfere with the procedures in this study * known or apparent pregnancy
the effects of nutrition supplementation and education on the healing of diabetic foot ulcer (dfu)

Conditions: Diabetic Foot Ulcer

Summary: the overall aim of this study was to assess the effects of nutritional supplementation and education on the healing of foot ulcers in diabetic patients. the hypothesis was that improving dietary intake can promote wound healing by improving nutritional status, blood flow, and decreasing inflammatory biomarkers while increasing anti-inflammatory factors.


Eligibility criteria:
inclusion criteria: male or non-pregnant, non-lactating female ages 50 ± 20 years, diagnosis of diabetes mellitus, undergoing pharmacological treatment for glycemic control, with at least one foot with one ulcer of grade 1a based on university of texas classification - exclusion criteria: subjects were excluded from the study if they had hba1c concentrations \> 12%, bioengineered tissue use within four weeks prior to initial screening, a history of radiation treatment to the ulcer site, known immunosuppression, active malignancy, chronic kidney disease, liver failure/cirrhosis, heart failure and/or myocardial infarction in the past three months, use of warfarin, alcohol abuse, or any mental or physiological condition that may interfere with nutrition education and nutritional supplement intake.-

Keywords: dfu, wound healing, nutrition education,supplementation
registry for evaluating outcome of acute ischemic stroke patients treated with mechanical thrombectomy.

Conditions: Ischemic Stroke

Summary: the bernese-european registry for ischemic stroke patients treated outside current guidelines with neurothrombectomy devices using the solitaire™ fr with the intention for thrombectomy (beyond-swift) is a retrospective, multi-center, non-randomized observational study aims to investigate the safety and efficacy of a medtronic market-released neurothrombectomy device (applied as initial devices used for intervention) in acute ischemic stroke patients who do not fulfill treatment eligibility according to current guidelines. patients will be treated or were treated at the discretion of the investigator, independent of participation in this registry. primary analysis is the impact of successful reperfusion on functional outcome at day 90 in patients presenting with large infarct cores (aspects\<6) or minor symptoms (nihss\<8).


Eligibility criteria:
inclusion criteria: * patients or patient's legally authorized representative have given informed consent according to good clinical practices (gcp) and/or irb and/or local or institutional policies. * the patient presents with an intracranial large vessel occlusion and therewith-related neurological symptoms and has been or will be treated with a medtronic marketed-release neurothrombectomy device (applied as first device to attempt retrieving the thrombus). exclusion criteria: * current participation in another clinical trial

Keywords: thrombectomy eligibility large vessel occlusion