Kornimate/medical-research-clean huggingface dataset:
expert panel statement for the respiratory management of covid-19 related acute respiratory failure (c-arf)

Conditions: Covid19; Acute Respiratory Failure; Acute Respiratory Distress Syndrome

Summary: the investigators aim to achieve experts consensus on respiratory interventions in management of covid-19 related acute respiratory failure (c-arf).

the investigators aim to achieve experts consensus on respiratory interventions in management of covid-19 related acute respiratory failure (c-arf). the pandemic of covid-19 is unique in terms of a multitude of patients suffering from arf and requiring invasive mechanical ventilation with single underlying inciting etiology.the experts have given divergent opinions on respiratory support of c-arf which may have confused physicians globally. the investigators are going to use a modified delphi based methodology involving global participating experts. the objective is to achieve consensus statement on the management of c-arf using "collective intelligence". the whole process of this study will be done in the form of two-three rounds of google forms-based delphi surveys. in this survey questionnaire, the investigators have prepared statements on the concern areas in the respiratory support of c-arf. the survey has been divided into five sections related to c-arf management. the majority of these statements are to be rated on likert scale and others have multiple choices. there is an option for collecting participating experts comments in provided open space in round one which will be considered during round two questionnaire.

Eligibility criteria:
inclusion criteria: (all the three criteria should be there) h index more than 10; one or more publication on respiratory failure in indexed journal; actively involved in management of covid-19 related acute respiratory failure. exclusion criteria: not meeting inclusion criteria
pro-calcitonin marker as indicator of ischemia in patients with complicated coronary intervention.

Conditions: Coronary Disease

Summary: the aim of this study is to determine on preliminary basis weather an elevated pro-calcitonin level can be used to assess ischemia as a result of coronary artery complications during percutaneous coronary intervention (pci).

pro-calcitonin is a type of protein found in the blood. this protein has recently be found to be elevated in patients with diseases of the arteries of the heart such as heart attack. percutaneous coronary intervention (pci) is widely used in the treatment of many patients with blockage in the arteries of the heart. the investigators normally used a marker called troponin after cardiac catheterization. however, this marker may not be specific. pro-calcitonin has been found to be a useful marker for the detection of myocardial injury. the value of pro-calcitonin as a marker for the identification of myocardial damage undergoing pci has not yet been studied.

Eligibility criteria:
inclusion criteria: * patients older than 18 years old. exclusion criteria: * no consent. * suspicion of sepsis. * patients with elevated troponin or procalcitonin before enrollment. * patients who had non-elective angioplasty (e.g. rescue angioplasty, primary angioplasty, salvage angioplasty, or emergency angioplasty)
effect of intravitreal bevacizumab on clinically significant macular edema

Conditions: Diabetic Macular Edema

Summary: to compare the effect of intravitreal bevacizumab alone or in combination with triamcinolone acetonide with laser photocoagulation on clinically significant macular edema (csme)

we entered 150 eyes into the study that recruitment of cases finished recently.eligible eyes randomly assign to one of the study arms including intravitreal bevacizumzb, intravitreal bevacizumzb/triamcinolone and macular photocoagulation groups. every patient needs at least 1 year followup. during this time bcva, oct, fa will be done for each patient and inaccording to interpretation of datas and fundus exam repeatation of injection will be done.

Eligibility criteria:
inclusion criteria: * case with clear media iop below 23 mm/hg female after menopause at least for 12 months or had 2 contraceptive roots visual acuity between 20/50 to 20/320 exclusion criteria: * no prp or n.d yag laser in past 6 months no intraocular surgery in past 12 months * cva in past 12 months blood sugar above 250 * active infection in extraocular adnexa

Keywords: bevacizumab csme mpc triamcinolone acetonide
a nis evaluating injectable treatments in patients with relapsing multiple sclerosis

Conditions: Relapsing Multiple Sclerosis

Summary: this is an observational, non-interventional, multicenter, open-label study in patients being treated with any approved injectable disease-modifying therapy (dmt) for relapsing multiple sclerosis in germany. prospective, primary data will be collected via questionnaires and an electronic case report form (ecrf) over a period of up to approx. two years of treatment. additionally, medical history of participants will be collected including disease duration, edss, mri parameters and relapses.

the prerequisite for participation in this observational study is the independent decision of the treating physician and patient to start an approved injectable dmt for rms as routine medical treatment. this decision must have been made prior to enrollment in this study. the prospective observational period per patient will be up to approx. two years from the time of consent (2 years +2 months visit window). the observational period will not be dictated by the protocol. the follow-up documentation will take place at a frequency defined as per investigator's discretion. the diagnostic or monitoring procedures are only those ordinarily applied to the therapeutic strategy and to routine clinical care, can be performed as telemedicine visits and will take place as per investigator's discretion.

Eligibility criteria:
inclusion criteria: 1. signed informed consent must be obtained prior to participation in the study 2. male or female patients aged ≥18 years at enrollment 3. diagnosis of ms according to the 2017 revised mcdonald criteria (thompson et al 2018b) 4. rms with active disease as defined by lublin et al. (2014) 5. max. 1 relapse during the previous year and max. 2 relapses during the previous two years prior to enrollment 6. disability status at enrollment with an edss score of 0 to 2.5 (inclusive) 7. planned initiation or initiation within the past 14 days with an approved injectable dmt for ms as routine medical treatment exclusion criteria: 1. patients being treated outside of the approved label 2. \> 5 years since first symptom(s) (leading to ms diagnosis) at enrollment 3. previous therapy with any dmt for the treatment of ms prior to enrollment (except within the past 14 days with an approved injectable dmt for ms as routine medical treatment; see inclusion criteria #7) 4. relapse prior to enrollment which has led to a severe deficit relevant to everyday life upon discretion of the investigator after exhaustion of the relapse therapy 5. poor recovery from the first two relapses prior to enrollment upon discretion of the investigator 6. edss functional system score "pyramidal functions" ≥ 2 at enrollment 7. simultaneous participation in any investigational trial or simultaneous participation in another novartis-sponsored non-interventional study with ofatumumab

Keywords: relapsing multiple sclerosis rms nis ofatumumab
continuous monitoring of right ventricular function, based on the correlation between the c-x segment of the central venous pressure curve, and the echocardiographic evaluation of right ventricular systolic function

Conditions: Heart Surgery; Ultrasonography Right Ventricle Systolic Function

Summary: close analysis of right ventricular function is still not done by all clinicians, even though it is indispensable; notably in cardiovascular icus. right ventricular dysfunction is responsible for increased morbidity and marks a turning point in the patient's prognosis. it is difficult to analyse, and is principally assessed using echocardiography and by measuring the peak of the s' wave with pulsed doppler and by measuring the tricuspid annular plane systolic excursion (tapse) in the tm mode. new studies have shown the interest of using 2d strain as a marker of systolic and diastolic function of the right ventricle. finally, the use of 3d ultrasound seems to be more reliable than cardiac mri for fine analysis of the right ventricle, even though it is rarely used in routine practice. study of the right ventricle using ultrasonography alone requires experienced and available operators for closely repeated evaluations making it possible to detect right ventricle dysfunction quickly. us monitoring of left and right heart function is done systematically and repeatedly during post-operative care following heart surgery. this us evaluation could be optimized by finding a way to monitor the right ventricle continuously. from a physiological point of view, we know about the tight relationship between the aspect of the central venous pressure curve and more precisely the c-x segment (tricuspid bulging into the atrium and start of contraction of the right ventricle) and right ventricular function. we wish to analyse this segment, combined with a us evaluation, and to look for a possible correlation so as to allow continuous, easy-to-interpret monitoring of right ventricular systolic function. this will be facilitated by the systematic presence of a central venous catheter in every patient undergoing heart surgery, thus allowing central venous pressure to be monitored. to this end, we wish to collect different data from patients in the cardiovascular icu, especially the central venous pressure curve, the ventilatory pressure curve and settings of the respirator, and to carry out an echography evaluation of each patient.


Eligibility criteria:
inclusion criteria: * patients admitted to the cardiovascular icu * patients with spontaneous breathing * with a central venous catheter placed in the internal jugular vein and for whom the central venous pressure curve is exploitable * with a us window allowing a 4-chamber view making it possible to calculate the right ventricle ejection fraction (peak of the s' wave, of the tapse, strain of the right ventricle) exclusion criteria: * non-echogenic patients or those without an exploitable us window * patients without a central venous catheter in the internal jugular vein * patients with an unexploitable central venous pressure curve
reminiscence therapy on depression, self esteem, life satisfaction, and loneliness of the elderly

Conditions: Depression

Summary: the primary hypothesis is, comparing with the control group, reminiscence therapy is significantly and clinically effective to improve the experiment group's depressive symptoms after six weeks therapy, and the efficacy can be maintained on the three months follow-up. the secondary hypothesis is, comparing with the control group, reminiscence therapy significantly reduce the loneliness and increase the self-esteem and life satisfaction of the experiment group.

the subjects who are arranged to the experiment group will be intervened using the reminiscence therapy manual proposed by watt and cappeliez (2000). according to the manual, the group consisted of six weekly sessions of 90 min each. during each weekly session, the memories recalled focused on a different theme. data collection will occur on screening (as for baseline or pre-test), after intervention immediately (as for post-test), and three months after the intervention (as for follow-up). and outcome measures use standardized instruments with demonstrated validity and reliability: geriatric depression scale (gds) rosenberg self-esteem scale (ses) life satisfaction index a (lsi-a) russell's ucla loneliness scale

Eligibility criteria:
inclusion criteria: 1. 60 years of age and older; 2. a score above 10 and lower than 26 on the geriatric depression scale (gds); 3. a score of 24 or higher on the mini-mental state examination (mmse); 4. not taking anti-depressant medication or taking part in other psychotherapy when enrolling, if taking anti-depressant medication, must be stabilized on that medication for at least three months; 5. having no problem with communication (such as, can speak fluent mandarin, or if he/she speaks a dialect, his/her dialect can be understood by most of people). exclusion criteria: 1. suicide attempt; 2. a diagnosis of cognitive impairment by dsm-ⅳ, or mental disorders other than depression; 3. alcohol or drug abuse; 4. cannot grantee attending the therapy at a weekly base due to physical impairment, lack of time or unwilling etc.
hospice quality score assessment post pharmacist intervention

Conditions: Respiratory Disease; Cardiovascular Diseases; Neurologic Disorder; Dementia; Cancer

Summary: the study aims to investigate the impact of pharmacist delivered interventions on hospice patients quality metric scores.

the objective of this study is evaluate a program at a hospice involving activities designed to improve the site's national quality forum (nqf) and consumer assessment of healthcare providers and systems (hcahps) scores. these scores are calculated by the hospice using existing patient satisfaction survey scores (hcahps). the institution quantifies their compliance with national quality metrics (nqf) and reports this existing data to the pharmacist providing counseling services to their patients. the pharmacist assesses for areas for improvement and provides additional counseling services to improve the continuity and quality of care. the pilot program is scheduled to launch april 2020 and the researchers will look to assess for changes in the nqf scores, hcahps scores, and time for their partnering pharmacy to refill the first set of prescriptions.

Eligibility criteria:
inclusion criteria: adult patients who were referred to hospice by a healthcare provider exclusion criteria: patients 89 years or older

Keywords: national quality forum score hcahps medication refill number medications
recanalization rate of acute dvt

Conditions: Acute DVT of Lower Extremity

Summary: rporting and evaluation of the rate of recanalization of acute dvt of the lower limb at one year follow-up comparing the results of using noacs vs. conventional treatment.

deep vein thrombosis (dvt) is an important cause of disability and mortality in our society . the incidence of dvt significantly increases with age, being more prevalent in women than men . the location of dvt is also an important factor to be studied because of its association with pulmonary embolism and development of post-thrombotic syndrome (pts) , currently, duplex ultrasound scanning (dus) is the method of choice for diagnosis of dvt because it is non-invasive, provides real-time imaging, and has high sensitivity and specificity especially for detection of proximal dvt . the new oral anticoagulants (noacs), are poised to replace warfarin for treatment of the majority of patients with venous thromboembolism (vte), with a rapid onset of action and the capacity to be administered in fixed doses without routine coagulation monitoring, noacs have been shown to be noninferior to conventional anticoagulant therapy for prevention of recurrence with less bleeding. most studies have reported that more advantages than disadvantages for noacs when compared with vkas, with the most important advantages of noacs including safety issues (ie, a lower incidence of major bleeding), convenience of use, minor drug and food interactions, a wide therapeutic window, and no need for laboratory monitoring. nonetheless, there are some conditions for which vkas remain the drug of choice.

Eligibility criteria:
inclusion criteria: * • patients suffering from first attack of acute dvt (de novo) of the lower limb who (only femoral-popliteal type) aged 18 - 80 years. exclusion criteria: * patients suffering from recurrent dvt. * patients with acute dvt candidate for cdt (limb threatening acute dvt). * patients suffering from acute dvt with malignancy. * pregnant and lactating females. * patients with severe renal impairment (crcl \<30ml/min), severe hepatic impairment.
impact of external nasal dilator on the rhinogram

Conditions: Nasal Obstruction

Summary: the aim of this study is to present new data for a better understanding of the anatomic correlation of these two notches. this study included 32 nasal cavities (16 individuals) with external nasal dilator strip (breath right®) and after decongestion (0.05% oxymetazoline chloride applied as an aerosol spray);

acoustic rhinometry is more accurate in the anterior portion of the nasal cavities, from the nostril to the nasal valve (nv), the most important site of nasal obstruction. literature presents different opinions regarding the anatomical correlation of the two notches at the beginning of the rhinogram curve in normal adult caucasian individuals. this prospective study included 32 nasal cavities under the following conditions: 1st - basal condition; 2nd - with external nasal dilator strip (ends) (breath right®); 3rd - after decongestion (0.05% oxymetazoline chloride applied as an aerosol spray); 4th - after decongestion with ends.

Eligibility criteria:
inclusion criteria: * adult, caucasian exclusion criteria: * allergies, sinusitis, nasal polyps, external nasal deformities congenital or acquired, obstructive nasal deviation and regular use of any drug.

Keywords: external nasal dilator strip nasal valve acoustic rhinometry
t cell dysfunction in esrd

Conditions: ESRD; T-Cell Dysfunction

Summary: patients with end-stage renal disease (esrd) suffer from high morbidity and mortality of cardiovascular and infectious disease and increased risk of all-cause mortality which is mainly attributed to the disturbed immune response. more and more evident indicated that t cell dysfunction was universal in esrd. however, few studies clarified the association of t cell dysfunction and clinical outcomes. this study is aim to explore valuable markers of t cell dysfunction predicting bad clinical outcomes including death, cardiovascular disease, infection and tumor. hopefully, these finding will provide foundation for further mechanism research and better therapeutic options for esrd patients in the future.

patients with end-stage renal disease (esrd) suffer from high morbidity and mortality of cardiovascular and infectious disease and increased risk of all-cause mortality which is mainly attributed to the disturbed immune response. more and more evident indicated that t cell dysfunction was universal in esrd. recent evidence suggests uremia-related immune changes resemble to aging immune system, increasing immunological age of t cells by 20-30 years. as compared to an age-matched healthy control, esrd patients present a lower thymic output of naïve t cells, a decline in the t-cell telomere length and an increase in the differentiation status towards the terminal differentiated memory phenotype with a large number of cd28-negative t cells. more importantly, these changes are strongly associated with a history of cardiovascular diseases and the occurrence of severe infectious episodes in this population, supporting the idea that t cell dysfunction is a critical feature in this population and will impact clinical outcomes profoundly. this study prospectively researched the predictive value of t cell dysfunction for all-cause mortality and clinical complication in hemodialysis (hd) patients.

Eligibility criteria:
inclusion criteria: * had been on hemodialysis treatment for at least 6 months in blood purification center,zhongshan hospital, fudan university exclusion criteria: * underwent any kind of cardiovascular or infection event in three months * with hematological diseases, rheumatic diseases, active malignancies * with history of human immunodeficiency virus infection * currently use of any immunosuppressants * not followed-up at zhongshan hospital, fudan university

Keywords: t cell dysfunction end-stage renal disease clinical outcome
gene and protein expression profiles after treatment of actinic keratoses

Conditions: Actinic Keratoses

Summary: the primary aim of this study is to investigate the effect of 5-fluorouracil, imiquimod, and melatonin for actinic keratosis on immunological gene, and protein expressions profiles. secondarily, the aim is to assess the effect of the treatment on the histopathology of actinic keratoses.


Eligibility criteria:
inclusion criteria: * participants should have a clinical diagnosis of actinic keratosis * participants should be 18 years old or above * participants must sign an informed consent exclusion criteria: * known allergic reaction to either 5-fluorouracil , imiquimod, or melatonin * immunomodulating treatment * predictable poor compliance (due to i.e. dementia, substance abuse, psychiatric disease, life-threatening disease or language barriers) * pregnant or breastfeeding * females not in menopause (defined as no menstruation during the last 12 months) should use a secure birth control (intrauterine devices, hormonal contraceptives including - oral pills, patches, vaginal rings and injections) during the entire period of the trial
patient-driven compression in urography

Conditions: Urologic Diseases

Summary: compression of the abdomen during urography with either a patient-regulated compression device or conventional compression. evaluation of radiation dose, image quality and patients' experiences

patients are subjected to radiation from radiographical studies. the nurse can reduce the radiation dose for the individual by using dose-reducing measures. one of these is compression. it is known that compression in urography reduces the radiation dose because the radiation has less tissue to transverse when it is compressed. by reducing patient radiation doses, the risk of harmful radiation effects is reduced. this study aims to study if a patient-regulated compression device can reduce the radiation dose as effectively as the conventional compression, regulated by the nurse. two compression devices are investigated in each patient, in randomized order. aims of the study: 1. evaluate if the radiation doses are comparable with a patient-regulated compression device and conventional compression. 2. evaluate image quality with the two devices. 3. describe patients' experiences from using the two devices.

Eligibility criteria:
inclusion criteria: * outpatients with a request for a urographic study exclusion criteria: * emergency studies, * cannot participate actively with compression, * contraindications to compression of the abdomen, * pregnancy, * inability to understand the language of the questionnaire

Keywords: urography radiation dosage image enhancement