Kornimate/medical-research-clean huggingface dataset:
assessment of endothelial function in patients with non alcoholic fatty liver disease and the impact of statin treatment

Conditions: Non Alcoholic Fatty Liver Disease

Summary: the aim of the current study is to evaluate the association of fatty liver severity and endothelial function in non-alcoholic fatty liver disease (nafld) patients and to find the impact of statin treatment compared to usual care or life style modification on endothelial function, liver steatosis and fibrosis.

the study cohort will include 150 patients with fatty liver per ultrasound or histology. the patients will be divided randomly to one of three arms: follow up group, lifestyle modification group, and statins therapy (atorvastatin 20mg/d for 6 months). at screening, after 6 months (end of treatment), and 12 months the patients will undergo: 1. complete physical examination 2. blood pressure measurement 3. assessment of height and weight, body mass index and waist circumference 4. blood samples for complete blood count, fasting plasma glucose, fasting plasma insulin, lipid profile, liver enzymes, albumin, bilirubin, prothrombin time (pt inr), hemoglobin a1c, ferritin, adiponectin, c-reactive protein, tumor necrosis factor alpha, lipoprotein-phospholipase a2, apolipoproteins b100, a1, c3, c4, ceruloplasmin 5. liver elastography and sonographic liver fat quantification 6. brachial artery flow-mediated dilatation (fmd) measurement

Eligibility criteria:
inclusion criteria: * subjects willing to comply with study requirements and have signed an informed consent form * fatty liver per abdominal ultrasound or liver biopsy exclusion criteria: * alcohol drinking \>140g/week * presence of hepatitis b or c or hiv * known liver disease other than fatty liver * usage of drugs known to cause liver steatosis * subjects with known allergies or hypersensitivity to statins * subjects with known cardiovascular/cerebrovascular disease * subjects with known dyslipidemia requiring drug treatment * subjects with diabetes mellitus * history of drug or alcohol abuse * refusal to sig the informed consent form

Keywords: non alcoholic fatty liver disease endothelial function liver steatosis liver fibrosis statin treatment
usefulness of neutrophil gelatinase-associated lipocalin(ngal) to confirm acute kidney function decrease of the patients who had non-cardiac surgery

Conditions: Chronic Kidney Disease

Summary: although post-op renal function decrease is determined by serum creatinine, serum creatinine has disadvantages that it increases a long time after renal function decrease and it has various increasing time based on the level of renal function. neutrophil gelatinase-associated lipocalin (ngal's) usefulness as an evidence for acute kidney damage occurring from post-op cardiac surgery, being critical patients and contrast medium use is already proven. but ngal's usefulness for renal function after non-cardiac surgery is not proven and especially, ngal's usefulness for renal injury after non-cardiac surgery in chronic renal disease patients is not proven.therefore, the investigators will study about renal function decrease after non-cardiac surgery with ngal and serum creatinine.


Eligibility criteria:
inclusion criteria: * 43 patients who had non-cardiac surgery in seoul paik hospital. exclusion criteria: * have viral hepatitis and aspartate aminotransferase, alanine aminotransferase \> 2 time of normal level * severe lung disease * severe heart failure ( ejection fraction \< 40% ) * pregnancy
efficacy of telepsychiatry in the treatment of depression

Conditions: Depression

Summary: telepsychiatry is a novel means of providing expert psychiatric treatment to patients who live far from a source of care. if it can be demonstrated that treatment via telepsychiatry is as effective as in-person treatment, then many individuals with psychiatric illness will have easy access to psychiatric care, even if they live in geographically remote areas.

background: telepsychiatry is a novel means of providing expert psychiatric treatment to patients who live far from a source of care. if it can be demonstrated that treatment via telepsychiatry is as effective as in-person treatment, then many individuals with psychiatric illness will have easy access to psychiatric care, even if they live in geographically remote areas. objectives: the major goal of this study was to determine whether treatment of depressive disorders via telepsychiatry is as effective as in-person treatment. in addition, this study was designed to determine if depressed patients are as compliant and as satisfied with telepsychiatry as with in-person treatment. another goal was to compare the cost and cost-effectiveness of remote treatment via telepsychiatry to in-person treatment. methods: in this randomized controlled trial, veterans who presented with depression to any of three va maryland health care facilities with a scid-iv depression diagnosis and a hamilton rating scale for depression (ham-d) score of 16 or above were eligible for participation. eligible veterans were randomized to either "in-person" treatment or "remote" treatment. treatment occurred over six months and consisted of psychotropic medication and psycho-education concerning the disease, medications, and side effects. the major outcome variables included changes in ham-d depression ratings and beck depression inventory (bdi) self-reported depression ratings. status: completed.

Eligibility criteria:
inclusion criteria: depression, hamilton 16 or above, scid-iv depression diagnosis exclusion criteria:
characterisation of gut microbiota in patients undergoing gastrointestinal surgery with postoperative delirium (gim-pod)

Conditions: Postoperative Delirium; Gut Microbiota

Summary: the study is a case-controlled observational trial. sixty patients will be divided into 2 groups depending on whether postoperative delirium or not. this study aims to characterise the gut microbiota in patients undergoing gastrointestinal surgery with postoperative delirium. the cam-icu (confusion assessment method for intensive care unit) was used for delirium assessment.

the study is a case-controlled observational trial. sixty patients will be divided into 2 groups depending on whether postoperative delirium or not. this study aims to characterise the gut microbiota in patients undergoing gastrointestinal surgery with postoperative delirium. the cam-icu (confusion assessment method for intensive care unit) was used for delirium assessment. general anesthesia was induced as follows: 0.3 mg kg-1 intravenous (iv) etomidate, 2 mg iv midazolam, 0.4 μg kg-1 iv sufentanil, and 0.2 mg kg-1 iv cisatracurium. anesthesia was maintained with an end-tidal concentration of 2-3 vol% sevoflurane and 0.2-0.3 μg kg-1h-1 sufentanil to maintain the bispectral index between 40 and 60.

Eligibility criteria:
inclusion criteria: * 1. ethnic chinese; * 2. age, 18 to 80 years old; * 3. american society of anaesthesiologists (asa) physical status i or ii; * 4. required gastrointestinal surgery exclusion criteria: * cognitive difficulties * partial or complete gastrectomy * previous esophageal surgery * previous treated by radiotherapy or surgery * inability to conform to the study's requirements * deprivation of a right to decide by an administrative or juridical entity * ongoing participation or participation in another study \<1 month ago
effects o laughing qigong program on psychological outcomes and the physiological immunological responses

Conditions: Breast Cancer Survivors

Summary: laughter programs are safe, affordable, and age-appropriate activities. few studies have utilized mixed study designs to look at the impact on resilience in and experiences of participants in such activities.

the laughing qigong program is a physical and mental practice program that combines qigong and laughter. it is influenced by chinese local culture. it emphasizes the transformation of voice, body, and emotional use so that people can experience relaxation and tranquility, and then the transformation of emotions so that physical and mental energy can be released then to achieve balance. our research has shown that laughter-related psychological interventions have consistent effects on mental health, reducing mood conditions under life stress (grace, 2013), depressed mood (hsieh et al., 2015), and cortisol concentration (grace, 2013). however, there have only been a few studies where similar protocols focused on positive mental states (e.g. resilience, well-being) and the application of laughing in immune function. therefore, the current quasi-experimental trial was to investigate the effects of the lqp on psychological outcomes (resilience and well-being), mucosal immunity (salivary immunoglobulin a, s-iga), and immune-inflammatory index (interleukins, il-6) amongst breast cancer survivors. we hypothesized that (a) experimental group participants would have significantly higher levels of resilience and well-being at baseline (before the test) and post-treatment (post-test) compared to the wait list control group; (b) compared to the control group on the wait list, experimental group participants will have significant differences in mucosal immunity (s-iga) and inflammatory index (il-6) before and after the test; and (c) experimental group membership had a significant effect on psychological outcomes (resilience and well-being) as well as mucosal immunity (s-iga) and immune-inflammatory indices (il-6) after a 12-week lqp intervention

Eligibility criteria:
inclusion criteria: 1) female adult (18 years old); 2) diagnosed with stage i-iii breast cancer; 3) major treatment completed at least 3 months ago (i.e. surgery, chemotherapy, and/or radiotherapy); and 4) no communication difficulties (visual and auditory). exclusion criteria: 1) having recurrent or metastatic breast cancer; 2) being involved in other studies at the same time, 3) patients who are unable to cooperate with the trial and follow-up; and 4) having a history of mental illness in past 3 months (major depression disorder)..

Keywords: laughing qigong program, well-being, salivary biomarkers
vte incidence in severe sepsis and septic shock

Conditions: Severe Sepsis With Septic Shock

Summary: prospective studies on the incidence of vte during severe sepsis and septic shock remain absent, hindering efficacy assessments regarding current vte prevention strategies in septic patients. the investigators will prospectively study consecutively enrolled icu patients with severe sepsis and septic shock admitted at three hospitals. all patients will provide informed consent and the study will be irb approved. vte thromboprophylaxis, provided per standard of care and according to the patients' primary team, will be recorded for all patients. patients will undergo bilateral lower (and upper, if a central venous catheter \[cvc\] was present) comprehensive compression ultrasonography (cus) and will be followed for symptomatic deep vein thrombosis (dvt) and pulmonary embolism (pe) prior to discharge. the investigators will perform multivariate regression analyses to identify predictors of vte.


Eligibility criteria:
inclusion criteria: * icu patients with severe sepsis and septic shock exclusion criteria: * admission diagnosis of acute vte, * age \< 13 years, * pregnancy, * severe chronic respiratory disease, * severe chronic liver disease (child-pugh score of 11-15), * moribund patients not expected to survive 24 hours, and * acute myocardial infarction within 30 days.
atn 151 work-to-prevent: employment as hiv prevention

Conditions: HIV Prevention

Summary: the investigators aim to pilot-test a novel social and structural-level hiv intervention for ymsm and ytw of color ages 16-24.

work2prevent will advance the science by adapting, tailoring, and pilot-testing a novel social and structural-level hiv intervention for ymsm and ytw of color ages16-24 aimed at increasing economic stability (i.e., employment) through youth empowerment and asset development, and decreasing hiv risk behaviors (i.e., sex work) associated with social and economic marginalization.

Eligibility criteria:
phase 2 inclusion criteria: 1. being male or assigned male at birth (ytw) 2. identifies as a man who has sex with men (ymsm) and/or a gay bisexual man or transgender woman/transwoman 3. identifies as african american/black or hispanic/latino 4. 16-24 years old 5. english-speaking (primary) 6. currently unemployed but seeking employment, or employed only part-time (35 hrs or less on avg/wk) 7. is able to attend a 4-session employment program phase 2 exclusion criteria: 1. individuals identifying as non-hispanic white 2. individuals not assigned male at birth 3. individuals with a known hiv positive-status at time of consent phase 3 inclusion criteria: 1. being male or assigned male at birth (ytw) 2. identifies as a man who has sex with men (ymsm) and/or a gay bisexual man or transgender woman/transwoman 3. identifies as african american/black or hispanic/latino 4. 16-24 years old 5. english-speaking (primary) 6. currently unemployed but seeking employment, or employed only part-time (35 hrs or less on avg/wk) 7. is able to attend a 4-session employment program 8. did not participate in phase 2 phase 3 exclusion criteria: 1. individuals identifying as non-hispanic white 2. individuals not assigned male at birth

Keywords: youth empowerment employment intervention young men who have sex with men young transgender women
hydratation status at initiation of peritoneal dialysis: study of the role of peritoneal permeability

Conditions: Fluid Overload; Peritoneal Hyperpermeability; Peritoneal Dialysis; Chronic Kidney Disease

Summary: bioimpedance is recently known to be a reliable, reproducible and validated technic allowing determination of hydratation status in patients with chronic kidney disease treated with peritoneal dialysis (pd). overhydratation attested by bioimpedance is strongly associated with cardio-vascular morbidity and mortality in patients with pd. overhydratation might concern more than half of patients at pd initiation, though the underlying mechanism remains unknown. high peritoneal permeability (hpp) might concern about a third of patients starting a pd, although only a few datas are published on this condition. hpp at initiation of pd is associated with a decrease in both technical and patient survival and might be responsible of ultrafiltration failure. the underlying mechanisms of hpp at initiation of pd also remains unknown. to our knowledge, the correlation between hydratation status and peritoneal permeability at initiation of peritoneal dialysis remains unknown. moreover, there is no datas concerning the cinetic evolution of peritoneal permeability; demographic or biologic factors associated with hpp in days and months following pd start. the aim of the present study is to correlate hydratation status (attested by bioimpedance) and peritoneal permeability at early start of peritoneal dialysis. thus, we investigated early cinetic of peritoneal permeability at different time point during the first year of peritoneal dialysis and we analyzed the demographical and biological factors associated with hpp and overhydratation during this period. this study is a prospective, multicentric cohort study. fourty patients recruited in a two years' period in five centers of nephrology will be included. hydratation status will be determined with fluid overload measurement by bioimpedance technic thanks to bcm system (fresenius medical care®). peritoneal permeability will be determined by modified peritoneal equilibration test with complete drainage at sixty minutes. datas will prospectively be collected, including: weight, blood pressure, diuretic posology, diuresis, pd modality, dialysate prescribed.


Eligibility criteria:
inclusion criteria: * end stage chronic kidney disease * ambulatory * starting a peritoneal dialysis in one of the participant centers * accepting the study protocol * age \> 18yo exclusion criteria: * age \<18yo * protected by the law

Keywords: fluid overload hydratation statud peritoneal hypepermeability peritoneal dialysis impedancemetry
study of sunitinib in combination with folfox in patients with colorectal cancer

Conditions: Colorectal Neoplasms

Summary: to assess the safety and tolerability of sunitinib when administered in combination with modified folfox6 in japanese patients with metastatic colorectal cancer in the first-line treatment setting.


Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed adenocarcinoma of the colon or rectum with documented locally advanced or metastatic disease. * evidence of unidimensionally measurable disease as defined by the response evaluation criteria in solid tumors (recist). * eastern cooperative oncology group (ecog) performance status of 0 or 1. exclusion criteria: * prior treatment with systemic therapy for locally advanced or metastatic colorectal cancer. * prior surgery or investigational agent within 4 weeks prior to study entry. * pregnancy or breastfeeding. all female patients of reproductive potential must have a negative pregnancy test (serum or urine) prior to the start of the study.

Keywords: phase 1 crc su011248 sunitinib folfox colorectal cancer metastatic carcinoma of the colon or rectum
outcomes and risk factors of cpr in picu

Conditions: Cardio Respiratory Arrest

Summary: 1. to detect the frequency and the underlying causes of cardiopulmonary arrest . 2. to detect outcome of cpr 3. to identify the associated risk factors for the different outcomes after cpr among those patients

cardiac arrest (ca) is uncommon in children, and the epidemiology of pediatric ca is different from adults. ca is a critical cause of death in children in the hospital especially in the pediatric intensive care unit (picu). ca is reported in 2-6% of children in the picu, which is much higher than out-of-hospital arrest (about 8 to 20 annual cases per 100,000 pediatric population . previous studies reported that return of spontaneous circulation (rosc) after cardiopulmonary resuscitation (cpr) for in-hospital ca (ihca) is about half of these patients, and ∼30% survived to hospital discharge previous studies had analyzed the cause and prognostic factors associated with outcomes after ihca, which included the initial rhythm, duration of ca and cpr, the underlying disease, and where the event attacked . patients in picu are more likely to develop ca because they are more critically ill. information on factors associated with prognosis of in-picu ca can promote improvement in picu care, which means improving survival with good neurologic outcomes . analyzing the epidemiological variables and risk/prognostic factors of in-picu ca is of great importance in developing the better therapeutic strategy and deciding appropriate preventive measure . probability of death on admission and a longer length of stay in the picu were associated with increased odds of receiving cpr. children admitted with cardiac conditions were at significantly higher risk of receiving cpr in the picu compared with those admitted with noncardiac primary diagnosis. the risk of receiving cpr was significantly associated with age, history of preadmission cpr, also, electrolyte imbalances and multi-organ dysfunction increase risk of receiving cpr in picu .

Eligibility criteria:
inclusion criteria: * including children aged 1 month to 18 years who received at least 1 minute of cpr exclusion criteria: * exclusion of 1-children aged below1 month and older than 18 years . * terminal disease patients, such as malignancy
short duration levetiracetam to extended course for seizure prophylaxis after asah

Conditions: Subarachnoid Hemorrhage

Summary: our primary objective is to compare two treatment options for prevention of seizures following a subarachnoid hemorrhage and determine if a short-course regimen of levetiracetam is as efficacious in the prevention of in-hospital seizures when compared to an extended course.

this is a prospective, single-center, randomized, controlled trial. patients admitted with spontaneous sah (and meet enrollment criteria) will be randomized to either levetiracetam 1000 mg twice daily for 3 days or levetiracetam 1000mg twice daily until hospital discharge.

Eligibility criteria:
inclusion criteria: 1. age \>18 years of age 2. diagnosis of spontaneous sah exclusion criteria: 1. sah secondary to trauma or arteriovenous malformation 2. early death (defined as death within 3 days of presentation) 3. known allergy to levetiracetam 4. know seizure history on chronic aeds 5. pregnancy 6. current incarceration

Keywords: subarachnoid hemorrhage seizure prophylaxis levetiracetam
real-world therapy of alk-positive nsclc in sweden: the sequencing of alk tyrosine kinase inhibitor drugs and their therapeutic outcomes based on data from national registers.

Conditions: ALK-positive NSCLC

Summary: this study aims to explore for the first time how the different alk tkis have been sequenced in real-world clinical practice and with which outcomes for swedish lung cancer patients


Eligibility criteria:
inclusion criteria: -inclusion criteria for alk-positive nsclc patients will be based on prescription data i.e. defines eligible patients as adult patients with at least one filled prescription of alk-inhibitors identified by the national prescription register. only prescriptions filled at pharmacies can be captured in prescription registers, as they do not include data on hospital drugs. alk-inhibitor treatments for patients with nsclc are given primarily outside of the hospital setting minimizing the selection bias under the inclusion criteria. exclusion criteria: -not applicable
oral zinc supplement as adjunctive therapy for erosive oral lichen planus

Conditions: Oral Lichen Planus

Summary: lichen planus (lp) is a chronic mucocutaneous inflammatory disease and considered as t-cell mediated autoimmune disorder. zinc is a potent antioxidant micronutrient that contributes to the proper functioning of the antioxidant defense system. in addition, this mineral protects cells against inflammation by oxidative stress, because it acts in the stabilization of cell membrane. it also maintains macrophage and neutrophil functions, natural killer cell activity, and complement activity. matrix metalloproteinases (mmps) are a family of zinc-containing endopeptidases and have the main function of proteolytic degradation of connective tissue matrix proteins. zinc prevents (mmp-1) activation and inhibition of the t-cell accumulation in (olp) through inhibiting of (mmp-9). aim of the study: to evaluate and compare the efficacy of adding oral zinc supplementation 50 mg to 0.1%triamcinolone orabase (ta)versus 0.1%triamcinolone orabase alone on the healing of erosive olp.


Eligibility criteria:
inclusion criteria: * all patients involved in this clinical trial will have symptomatic olp exclusion criteria: * smokers or tobacco users will be excluded from this clinical trial. * pregnant and lactating females. * any patient that has history of cancer, kidney, liver or other autoimmune disease will be excluded from this study. * patients showing dysplastic changes in their confirmatory biopsy specimen will be also excluded. * any patients presenting with extra oral lichen planus lesions will be excluded. * suspicious lesions of both lichenoid contact reaction and lichenoid drug reaction lesions will be excluded. * vitamin administration intake within the last 3 months