Kornimate/medical-research-clean huggingface dataset:
the effects of high-definition transcranial direct current stimulation on balance control in older adults with chronic low back pain

Conditions: Chronic Low Back Pain

Summary: the goal of this clinical trial is to investigate the effects and mechanisms of high-definition transcranial direct current stimulation over left dorsolateral prefrontal cortex on chronic low back pain and balance in older adults. the main questions it aims to answer are: primary hypothesis 1: active stimulation would have greater improvement in pain and balance, reduced left dorsolateral prefrontal cortex activation than sham stimulation. primary hypothesis 2: active stimulation would have enhanced functional connectivity than sham stimulation. primary hypothesis 3: the balance improvement would be related to reduced pain, decreased left dorsolateral prefrontal cortex activation, enhanced functional connectivity, attention, and/or executive function. participants will be randomly received a single-session of high-definition transcranial direct current stimulation (active or sham stimulation). before and immediately after the intervention, balance (semi-tandem stance and timed up-and-go test (tug)) and cognitive (attention and executive function) tests will be assessed.


Eligibility criteria:
inclusion criteria: * aged 60-85 years; * with non-specific chronic low back pain that has no definitive diagnosis but lasted for at least 3 months, typically occurs in the area between the lower rib margins and the buttock creases; * with an average pain intensity over the last week to be ≥ 3 on an 11-point numerical rating scale (nrs) anchored with "no pain" at zero and "worst pain imaginable" at 10; * have normal cognitive function (hong kong montreal cognitive assessment ≥ 22); * who agree to sign an informed consent form. exclusion criteria: * inability to ambulate without assistance from another person or tools (e.g., canes or walkers); * having specific causes of low back pain (e.g., spinal stenosis, lumbar disc herniation, spondylolisthesis, recent vertebral fracture, spinal infection); * having other acute or overt musculoskeletal conditions in other parts of the body (e.g., fractures, severe pain, multiple joint pain (e.g., knee pain)); * history of lumbar or lower extremity surgery; * receiving lbp treatment within the past one month or at present; * have never received non-invasive brain stimulation (e.g., transcranial direct current stimulation, repetitive transcranial magnetic stimulation, and transcranial alternating current stimulation) before.
phase ii trial of gleevec and taxotere as a combined regimen for advanced gastric adenocarcinoma

Conditions: Gastric Adenocarcinoma

Summary: the purpose of this trial is to test the combination of gleevec® (also known as imatinib mesylate) and taxotere (also known as docetaxel) in patients with incurable stomach cancer. this study is being performed to see if the combination of gleevec and taxotere is an effective treatment for incurable stomach cancer with minimal side effects.

the purpose of this trial is to test the combination of gleevec® (also known as imatinib mesylate) and taxotere (also known as docetaxel) in patients with incurable stomach cancer. gleevec is a pill form of chemotherapy and is indicated for the treatment of adult patients with chronic myeloid leukemia (cml) and gastrointestinal stromal tumors (gist). it is considered experimental for the treatment of stomach cancer. taxotere (docetaxel) is a chemotherapy which is injected into the vein. it is approved for breast and lung cancer but has been shown to shrink many different types of tumors. taxotere has been shown to shrink stomach cancer in about 20% - 30% of patients treated with taxotere only. this study is being performed to see if the combination of gleevec and taxotere is an effective treatment for incurable stomach cancer with minimal side effects. treatment on this study consists of two drugs, gleevec® and taxotere. patients will be take four tablets of gleevec® daily throughout the study. after one week of gleevec®, patients will then begin receiving doses of taxotere intravenously once a week for two weeks in a row followed by one week without taxotere.

Eligibility criteria:
inclusion criteria: * this study is for patients with histologically confirmed unresectable gastric adenocarcinoma and who have not received any chemotherapy other than 5-fu for adjuvant therapy either alone or in conjunction with radiation. exclusion criteria: * patients may not have received any chemotherapy agents other than 5-fu. * patients may not have received 5-fu for for therapy for metastatic gastric cancer. * patients must be more than 5 years free of another primary malignancy except: if other primary malignancy is a basal cell skin cancer or a cervical carcinoma in situ. existence of any other malignant disease is not allowed. * patients must not have grade iii/iv cardiac problems, or any severe and/or uncontrolled medical disease (i.e. uncontrolled diabetes, chronic renal disease, or active uncontrolled infection). * patient must not have had previously received radiotherapy to \>/= 25% of the bone marrow, or have had major surgery within 2 weeks prior to study entry * final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Keywords: gastric adenocarcinoma
cross-sectional study of the prevalence and risk factors of asymptomatic bacteriuria in pregnancy

Conditions: Urinary Tract Infection (Diagnosis); Pregnancy

Summary: asymptomatic bacteriuria (asb) is the presence of bacteria in the urine without symptoms of urinary tract infection. it is common during pregnancy and, if left untreated, may lead to complications such as pyelonephritis, preterm labor, and low birth weight. this cross-sectional study aims to determine the prevalence and identify associated risk factors of asb among pregnant women attending antenatal care at a tertiary care hospital. pregnant women meeting the inclusion criteria will be enrolled and evaluated through urine analysis and relevant history-taking. the findings may help guide future screening and treatment policies in antenatal care settings


Eligibility criteria:
inclusion criteria: * pregnant women attending her regular anc check-ups at the hospital. * who give consent to participate in the study. exclusion criteria: * individuals not willing to participate * pregnant women showing signs and symptoms of uti. * pregnant women on antibiotics or had been on antibiotics at least two weeks prior to presentation. * pregnant women with known underlying renal pathology. * pregnant women who are using immune-suppressants.
clinico-pathologic correlative study of 3t magnetic resonance spectroscopy in the localization of prostate cancer

Conditions: Prostate Cancer

Summary: we seek to develop an advanced imaging approach to identifying and localizing prostate cancer. we believe that high field mri (magnetic resonance imaging) has the potential to do this and we will endeavor to prove this by having patients with prostate cancer pre-operatively undergo a technique called magnetic resonance spectroscopy. after surgery, the microscopic locations of cancer will be compared with the pre-operative images to assess how well the imaging technique succeeds.

the proposed research is enormously relevant to the clinical understanding of early prostate cancer. we propose to test to see whether characteristic patterns of invivo 3t mrsi associated metabolites can be identified in correlation with clinically active tumor reserved on histopathologic analysis of resected specimens. we also plan to demonstrate that 3t mr spectra of prostate cancer will allow for more detailed metabolic assessment with higher sensitivity, specificity and accuracy and publish results established from mr spectra using 1.5t mr units. functional imaging (eg. molecular imaging such as this) is felt to be the clinical wave of the future for cancer imaging, and if successful, will assume a very major role in the detection, assessment, treatment planning and delivery of drugs, radiation, heat and novel therapeutics in the fight against prostate cancer.

Eligibility criteria:
inclusion criteria: * histologically verified prostate cancer * patient has opted for surgery * low risk prostate cancer psa \<1 0, gleason \< 7, stage \< t2b * no contraindication to mr scanning * no prior history of malignancy * fit for surgery exclusion criteria: * nonbiopsied lesion * intermediate or high risk prostate cancer * unfit for surgery * contraindication to mr scanning (i.e. pacemaker, aneurysm clips, claustrophobia)

Keywords: magnetic resonance imaging prostate cancer imaging 3t mrs functional imaging
combined anterior suprascapular nerve block and superficial cervical plexus block in shoulder arthroplasty surgery

Conditions: Diaphragmatic Paralysis; Anterior Suprascapular Nerve Block; Superficial Cervical Plexus Block; Phrenic Nerve Paralysis

Summary: the suprascapular nerve, originating from the c5 trunk, provides innervation to the acromioclavicular and glenohumeral joints. the supraclavicular nerve, a branch of the cervical plexus, contributes to the sensory innervation of the upper deltoid region. cervical and brachial plexus blocks can cause diaphragm paralysis. this study examined the effects of low-volume combined anterior suprascapular nerve block and superficial cervical plexus block on pain and phrenic nerve in participants underwent reverse shoulder arthroplasty surgery.

a retrospective analysis was performed on data obtained from eight participants who underwent reverse shoulder arthroplasty surgery. anterior suprascapular nerve block and superficial cervical plexus block were applied to these participants. anterior suprascapular nerve block was performed using 5 ml and superficial cervical plexus block was performed using 3 ml of %0,5 bupivacaine. ultrasound was used to measure the diaphragm thickness at the end of inspiration and expiration, and to calculate the diaphragm thickness fraction. postoperative pain management included patient-controlled analgesia with morphine, opioid consumption and vas score recorded by pain observation forms. data will be collected by examining these pain observation forms and diaphragm thickness measurements.

Eligibility criteria:
inclusion criteria: * population is defined by database within a given time frame * participants who underwent combined anterior suprascapular nerve block and superficial cervical plexus block in reverse shoulder arthroplasty surgery * participants aged 18-80 * asa i-ii-iii exclusion criteria: * asa score \> iii * pediatric individuals under 18 years of age * individuals who are pregnant * known diaphragmatic paralysis * had an allergy or toxicity to local anesthetic agents * have an opioid drug allergy

Keywords: diaphragmatic paralysis anterior suprascapular nerve block superficial cervical plexus block reverse shoulder replacement shoulder pain
comparing remote interpreter modalities in the pediatric emergency department

Conditions: Limited English Proficient Patients and Families

Summary: professional interpretation improves quality of care for patients with limited english proficiency (lep). however, many health care settings lack access to professional interpreters, and even in locations with good access, logistical factors and perceived barriers have limited their widespread use. remote methods of professional interpretation, including telephone and video, hold great promise for expanding access, but only limited data exist on the relative impacts of these modalities on patient care and provider uptake. comparing how these modalities impact multiple aspects of health care quality, including family comprehension, provider communication, and consistency of provider interpreter use will inform dissemination of strategies for delivery of safe, efficient, and equitable care to lep families. aim 1: to determine whether randomly assigned remote interpreter modality (telephone versus video) impacts parent-reported quality of communication and interpretation, diagnosis comprehension, and length of stay (los) among lep spanish-speaking families seen in a pediatric emergency department (ed). hypothesis 1: parent-reported quality of communication and interpretation and parent diagnosis comprehension will be higher among families assigned to video interpretation compared to telephone interpretation. hypothesis 2: los will not differ between families assigned to video and telephone interpretation. aim 2: to determine whether assigned interpreter modality is associated with provider decision to communicate without professional interpretation. hypothesis 3: parent-reported provider communication without professional interpretation (e.g. using the patient or a family member to interpret for some part of the visit) will be lower for families assigned to video interpretation compared to telephone interpretation.


Eligibility criteria:
inclusion criteria: * preferred language for medical care of spanish * at least one primary caregiver requires interpretation * presenting to seattle children's ed during recruiting hours exclusion criteria: * triage level 1 (life-threatening illness) * no parent or legal guardian present * reason for visit is concern for abuse * reason for visit is primary behavioral or psychiatric complaint
dapivirine gel rectal safety and pk study

Conditions: HIV 1 Infection

Summary: dapivirine gel rectal safety and pk study

a randomized, double blind, placebo-controlled phase 1 safety and pharmacokinetic study of dapivirine gel (0.05%) administered rectally to hiv-1 seronegative adults

Eligibility criteria:
inclusion criteria: * age of 18 - 45 years (inclusive), verified per site sop * able and willing to provide written informed consent * hiv-1/2 uninfected at screening and enrollment, per applicable algorithm in appendix ii and willing to receive hiv test results * able and willing to provide adequate locator information, as defined in site sop * available to return for all study visits and willing to comply with study participation requirements * in general good health at screening and enrollment, as determined by the site ior or designee * per participant report, a history of consensual rai at least once in the past calendar year * willing to not take part in other research studies involving drugs, medical devices, genital products, or vaccines for the duration of study participation, including the time between screening and enrollment exclusion criteria: at screening: * hemoglobin grade 1 or higher\* * platelet count grade 1 or higher\* * white blood count grade 2 or higher\* * serum creatinine 1.3 the site laboratory upper limit of normal (uln) * international normalized ratio (inr) 1.5 the site laboratory uln * aspartate aminotransferase (ast) or alanine transaminase (alt) grade 1 or higher\* * positive for hepatitis c antibody * positive for hepatitis b surface antigen * history of inflammatory bowel disease by participant report
impact of nudges on downloads of covid-19 exposure notification smartphone apps: a randomized trial

Conditions: COVID-19

Summary: eligible participants who were active beneficiaries of a large insurer living in pennsylvania were sent an email encouraging them to download the contact tracing app in pennsylvania, covid alert pa. participants will be randomly assigned to one of four conditions in a 2 (self-benefit vs. other-benefit) x 2 (social norms present vs. social norms absent) design. all participants received an email that said : "covid alert pa is the official exposure notification app from the pennsylvania department of health. join penn medicine in the fight against covid-19 and download covid alert pa today!" ---investigators manipulated the content here--- "the app uses bluetooth to sense when one person is in close contact with another person with the app. if someone tests positive for covid-19, and they decide to upload the information to the health department, people who have the app and who have been in contact with them will be alerted. if you are interested in downloading the app, please click covid alert pa. we appreciate you joining our efforts. together we can beat covid-19!" in the other-benefit condition, it said: "it can help you reduce your risk of unknowingly spreading the virus to your friends, family, and larger community." in the self-benefit condition, it said: "it can help you determine where and when to get testing, and how to get care if you need it." in the social norms present condition, it said: "over 650,000 pennsylvanians have already downloaded the app!" in the social norms absent condition, it said the statement about social norms above. participants who do not open the initial email received a follow-up email.


Eligibility criteria:
inclusion criteria: * eligible participants were active beneficiaries of a large insurer living in pennsylvania. exclusion criteria: * participants who did not subscribe to offers and promotions emails were excluded, as were medigap beneficiaries.
effects of dietary polystyrene microplastics on anxiety- and depression-like behaviors

Conditions: Depression, Anxiety

Summary: the objective of this clinical trial is to explore the potential impact of dietary polystyrene microplastics on anxiety- and depression-like behaviors in resident physicians. specifically, the study aims to address two key questions: 1. can dietary polystyrene microplastics induce alterations in the human gut microbiome? 2. can dietary polystyrene microplastics exacerbate anxiety- and depression-like behaviors? participants will be divided into two groups based on their habitual eating practices: the control group, consisting of resident physicians, will use non-disposable plastic tableware (ndpt) provided by hospital canteens for two months. in contrast, the exposure group, also comprising resident physicians, will use disposable plastic tableware (dpt) made of polystyrene, provided by the same hospital canteens, over the same period.

the mental health and well-being of resident physicians is a critical topic that has gained increasing attention recently. recent studies have shown a growing prevalence of mental health illnesses worldwide. for medical trainees and resident physicians, high rates of depression, anxiety, suicidal ideation, and burnout have been consistently observed. moreover, contemporary research suggests that dietary exposure plays a pivotal role in the development of mental illnesses. disposable plastic tableware, commonly used during resident training programs, could be a contributing factor. however, the specific effects of dietary exposure from such tableware on mental health, particularly through the gut-brain axis, remain largely unexplored. consequently, investigating the potential impact of dietary polystyrene microplastics on anxiety- and depression-like behaviors in resident physicians is essential.

Eligibility criteria:
inclusion criteria: * volunteer resident physician at the base of northern jiangsu hospital, yangzhou, china exclusion criteria: * received chemotherapy, radiotherapy, or surgery in the 3 -6 months before sampling * diagnosed with mental illness * diagnosed with digestive system diseases

Keywords: gut microbiome anxiety depression polystyrene microplastics
virtual reality and fatigue education

Conditions: Fatigue; Anxiety

Summary: it was planned to evaluate the effect of distraction intervention with virtual reality and fatigue education on the level of fatigue and anxiety in children with cancer.

h1: the fatigue scores of the patients who received distraction intervention with virtual reality and were given fatigue training were lower than the group that was given only fatigue training. h2: the anxiety scores of the patients who received distraction intervention with virtual reality and were given fatigue training were lower than the group that was given only fatigue training. data collection after the child and his family are informed about the study, their written informed consent will be obtained. all children included in the study on the day (day 0) prior to the start of chemotherapy treatment will be given training on fatigue. in order to determine how he felt and his level of fatigue on the day of the training, it was planned to apply the child anxiety scale-state (cas-d), child fatigue scale-24 hours and visual fatigue scale at 16.00 (pretest). after randomization is achieved, a distraction intervention will be applied once a day for 10-15 minutes with virtual glasses on the 1st, 2nd and 3rd days of the chemotherapy treatment of the children in the study group. this intervention is planned to take place between 14.00-15.00 in the afternoon.

Eligibility criteria:
inclusion criteria: * be between 7-18 years old * inpatient chemotherapy treatment for more than three days * 4 weeks over the time of diagnosis (not in the induction phase) * having a hemoglobin level above the criteria for transfusion of blood products (8 mg/dl for hematological malignancies, below 7 mg/dl for oncological malignancies). * the child voluntarily agrees to participate in the study and consent is obtained from the child and parent exclusion criteria: * being in terminal period * undergoing a surgical operation * unwillingness to participate in the study

Keywords: virtual reality
cardiovascular treatment

Conditions: Obesity

Summary: exercise training is proved to protect against premature cardiovascular mortality. additionally there is evidence that relatively high exercise intensity may be an important factor for improving aerobic capacity and endothelial function in patients with post-infarction heart failure, metabolic syndrome, coronary artery disease, as well as in overweight and obese individuals. the aim of this study is to investigate the amount of high-intensity exercise needed to improve aerobic capacity and endothelial function.


Eligibility criteria:
inclusion criteria: * bmi: 25-30 * males, 35-45 years * healthy

Keywords: slightly overweight males 35-45 years
lactoserum (dermacyd femina®) and prevention of recurrence of bacterial vaginosis

Conditions: Bacterial Vaginosis

Summary: the purpose of this study is to demonstrate if the use of dermacyd can avoid the recurrence of bacterial vaginosis after three months of the standard treatment.


Eligibility criteria:
inclusion criteria: * women in reproductive age * confirmed cure of bacterial vaginosis after treatment with oral metronidazole. * vaginal bacterioscopic examination negative for candida and trichomonas. exclusion criteria: * pregnant or breastfeeding women * allergy to dermacyd the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.