Kornimate/medical-research-clean huggingface dataset:
18f-fspg pet/mri or pet/ct imaging of cardiac sarcoidosis or inflammation

Conditions: Cardiac Sarcoidosis; Myocardial Inflammation

Summary: the investigators will evaluate the detection of cardiac sarcoidosis or inflammation using 18f-fspg pet/mri (or pet/ct for participants with metal implants).

pet/mri scans will be performed with a whole-body pet/mr imaging system capable of simultaneous pet and mr imaging (signa, ge healthcare, milwaukee, wi). approximately 45-60 minutes after iv injection of 8 mci of 18f-fspg, pet emission scanning and mri acquisition t1 weighted scanning will begin imaging both whole body and the heart.

Eligibility criteria:
inclusion criteria: * patient is ≥ 18 years old at the time of the scan * patient with known or suspected cardiac sarcoidosis. * patient is capable of complying with study procedures * patient can remain still for duration of imaging procedure exclusion criteria: * patient is pregnant or nursing * metallic implants (contraindicated for mri) * history of renal insufficiency (only for mri contrast administration)

Keywords: pet/mr
study of aav-gad gene transfer into the subthalamic nucleus for parkinson's disease

Conditions: Parkinson's Disease

Summary: the purpose of this study is to determine the safety and efficacy of aav-gad gene transfer into the subthalamic nucleus (stn) region of the brain. this study involves the treatment of subjects with medically refractory parkinson's disease (pd). the gene transfer product, a disabled virus with a gene called gad, will be infused into the stn bilaterally using stereotactic surgical techniques. the overall goal of this approach is to normalize the activity of the stn and reduce the motor symptoms of pd. because the change in updrs demonstrated a positive outcome, the sham surgery subjects from the blinded portion of the study will be invited to crossover into the open-label arm portion of the study. the open-label arm will further evaluate the safety and efficacy of aav-gad gene transfer into the subthalamic nucleus (stn) region of the brain.


Eligibility criteria:
inclusion criteria: * idiopathic parkinson's disease * duration of disease for at least 5 years * levodopa responsiveness for at least 12 months * updrs part 3 score ≥ 25 or more in "off" state exclusion criteria: * past history of brain surgery for pd * beck depression inventory score ≥ 20 * any history of cerebral insult or central nervous system infection * cognitive impairment score \< 130 on the mattis dementia rating scale * focal neurological deficits * evidence of significant medical or psychiatric disorders * secondary parkinsonism * atypical parkinson's disease * history of substance abuse

Keywords: keywords: parkinson's disease gene transfer gene therapy subthalamic nucleus adeno-associated virus study placed in the following topic categories: ganglion cysts movement disorders parkinson disease basal ganglia diseases central nervous system diseases parkinsonian disorders neurodegenerative diseases brain diseases additional relevant mesh terms: nervous system diseases
the effect of theory menu-based intervention on vitamin d adherence in people with osteoporosis-pilot study

Conditions: Osteoporosis

Summary: this pilot study evaluates the effect of theory menu-based mini-videos on vitamin d adherence in older adult with osteoporosis. half of participants will watch the videos while the other half will receive usual care (treating physician advice).

osteoporosis is a common disease around the world. the morbidity and mortality attributed to osteoporosis is due to fracture. the evidence shows that vitamin d is effective in preventing osteoporotic fracture, however, adherence to vitamin d is low among people with osteoporosis (20%-60%). the health action process approach (hapa) has been found useful to describe, explain, and predict changes in health behaviours in a variety of setting. based on hapa, mini-videos will be developed aiming to increase vitamin d adherence in people with osteoporosis. mini-videos will address self-efficacy, outcome expectancy, risk perception and action and coping plan. this pilot study aims to evaluate the recruitment and participants' feedback about the mini-videos.

Eligibility criteria:
inclusion criteria: * over the age of 50 years * have been diagnosed with primary osteoporosis * have low vitamin d level (less than 75nmol/l) recently (within the previous month) * fluent in english exclusion criteria: * cognitive diseases * mal-absorption syndromes that may interfere with vitamin d absorption.
effects of instrumental and manipulative techniques for the suboccipital region in subjects with chronic mechanical neck pain

Conditions: Chronic Mechanical Neck Pain

Summary: the aim of the study is to compare the effectiveness between the suboccipital inhibition technique, the suboccipital inhibition carried out with the inybi instrument and the suboccipital inhibition with the inybi plus the upper cervical manipulation, all in patients with chronic mechanic cervicalgia, and to determine which of these techniques is the most effective in the variables studied. in order to do so, 96 subjects participated in the study, being assigned to the 3 intervention groups. we expected the combined treatment (inybi instrument + upper cervical manipulation) to be the one to produce the best results.


Eligibility criteria:
inclusion criteria: * participants aged between 18 and 40 all diagnosed with chronic mechanic cervical pain with an evolution of at least 3 months and who show pain that increases with maintained postures, during movement and during spinal muscles palpation. exclusion criteria: * participants that can't read and/or fill in the informed consent, either due to a language and/or cognition alteration or age-related factors. * subjects with psychological pathologies, such as hysteria, depression or anxiety. * subjects that have received a manual treatment two months before the beginning of the clinical trial. * subjects who have been recommended by a physician or an anesthetist to receive any type of analgesic, anti-inflammatory or neuromodulator medication, such as antidepressants, antiepileptics and benzodiazepines. if the patient took in this type of medication in an occasional way 72 hours before the beginning of the study, he/she could participate. * the treatment and assessment techniques will be avoided if: fear to vertebral manipulation in the upper cervical area or positive klein test and other integrity test of the vertebral artery, positive cervical instability test and positive spurling test (foraminal compression test).
ppmi tau pet imaging

Conditions: Parkinson Disease

Summary: the assessment of brain tau burden in participants with parkinson's disease in the ppmi study (ppmi tau pet imaging) will evaluate if \[18f\] pi-2620 facilitates better understanding of tau deposition in the brain in parkinson's disease (pd).

the assessment of brain tau burden in participants with parkinson's disease in the ppmi study (ppmi tau pet imaging) is a companion study to the parkinson's progression markers initiative clinical protocol (ppmi-002; nct04477785). after consenting to the ppmi clinical protocol, participants interested in completing an additional scan under this study will be asked to complete consent, additional activities, and one \[18f\]pi-2620 pet imaging scan as part of this study. enrollment in the ppmi tau pet imaging companion study will facilitate comparison of tau deposition to clinical, imaging, blood and csf tau already acquired in these ppmi participants under the ppmi clinical protocol. the primary goal of this imaging study is to test whether positron emission tomography (pet) with \[18f\] pi-2620 can visualize in vivo brain tau deposition in participants with pd. the secondary goal is to evaluate tau deposition in pd lrrk2 mutation carriers given recent data that tau pathology may be present in those individuals.

Eligibility criteria:
inclusion criteria: * enrolled in ppmi clinical protocol * able to provide informed consent * male or female (females must meet additional criteria specified below, as applicable) * females must be of non-childbearing potential or using a highly effective method of birth control 14 days prior to until at least 24 hours after injection of \[18f\]pi-2620. * non-childbearing potential is defined as a female that must be either postmenopausal (no menses for at least 12 months prior to pet scan) or surgically sterile (bilateral tubal ligation, bilateral oophorectomy or hysterectomy). * highly effective method of birth control is defined as practicing at least one of the following: a birth control method that results in a less than 1% per year failure rate when used consistently and correctly, such as oral contraceptives for at least 3 months prior to injection, an intrauterine device (iud) for at least 2 months prior to injection, or barrier methods, e.g., diaphragm or combination condom and spermicide. periodic abstinence (e.g. calendar, ovulation, symptothermal, post-ovulation methods) is not acceptable. * females of childbearing potential must not be pregnant, breastfeeding or lactating. * females of childbearing potential have a negative urine pregnancy test prior to \[18f\]pi-2620 injection on day of pet scan. exclusion criteria: * exposure to an effective radiation dose of 50 msv, which would be above the acceptable annual limit established by the us federal guidelines during the past year. * any other medical or psychiatric condition or lab abnormality, which in the opinion of the site investigator might preclude participation.
safety and effectiveness of the pxl-platinum 330 system for corneal cross-linking in eyes with corneal ectasia

Conditions: Keratoconus; Pellucid Marginal Corneal Degeneration; Corneal Ectasia

Summary: to evaluate the safety and effectiveness of the pxl platinum 330 system for performing corneal cross-linking (cxl) for the treatment of ectatic disorders.

patients with progressive keratoconus, pellucid marginal degeneration, or at risk for post-refractive corneal ectasia will be recruited and undergo epithelial-on corneal crosslinking with the peschke pxl-330 system using pulsed, accelerated energy delivery. patients will undergo monitoring for 1 year, with serial measurements of corneal topography, visual acuity, intraocular pressure, pachymetry, and visual function questionnaire.

Eligibility criteria:
inclusion criteria: subjects who have one or both eyes that meet criteria 1 and 1 or more of the following criteria will be considered candidates for this study: 1.10 years of age or older 2. presence of central or inferior steepening 3. axial topography consistent with keratoconus, post-surgical ectasia, or pellucid marginal degeneration 4. presence of one or more findings associated with keratoconus or pellucid marginal degeneration, such as: 1. fleischer ring 2. vogt's striae 3. decentered corneal apex 4. munson's sign 5. apical corneal scarring consistent with bowman's breaks 6. scissoring of the retinoscopic reflex 7. crab-claw appearance on topography 5. steepest keratometry (kmax) value ≥ 47.20 d 6. i-s keratometry difference \> 1.5 d on the pentacam map or topography map 7. posterior corneal elevation \>16 microns 8. thinnest corneal point \>300 microns 9. contact lens wearers only: a. removal of contact lenses for the required period of time prior to the screening refraction: contact lens type minimum discontinuation time soft or scleral 3 days rigid gas permeable 2 weeks exclusion criteria: all subjects meeting any of the following criteria will be excluded from this study: 1. eyes classified as either normal or atypical normal on the severity grading scheme. 2. corneal pachymetry at the screening exam that is \<300 microns at the thinnest point in the eye(s) to be treated. 3. previous ocular condition (other than refractive error) in the eye(s) to be treated that may predispose the eye for future complications, for example: 1. history of or active corneal disease (e.g., herpes simplex, herpes zoster keratitis, recurrent erosion syndrome, acanthomeoeba, etc.) 2. clinically significant corneal scarring in the cxl treatment zone that is not related to keratoconus or, in the investigator's opinion, will interfere with the cross-linking procedure. 4. pregnancy (including plan to become pregnant) or lactation during the course of the study 5. a known sensitivity to study medications 6. patients with nystagmus or any other condition that would prevent a steady gaze during the cxl treatment or other diagnostic tests. 7. patients with a current condition that, in the physician's opinion, would interfere with or prolong epithelial healing.
the influence of a fasting mimicking diet on ulcerative colitis

Conditions: Inflammatory Bowel Disease; Diet Modification; Ulcerative Colitis

Summary: the purpose of this study is to see how a diet that mimics fasting effects inflammation in patients with mild to moderate ulcerative colitis (uc). the diet may allow users to receive the benefits of fasting while also being able to enjoy food (the ingredients of which are gras (generally recognized as safe) by the food and drug administration (fda). research on dietary interventions and uc are very limited. fasting mimicking diets (fmd) have been studied with support of the national institute of health and published in leading journals. this research investigates whether markers of inflammation decrease and/or quality of life increases after three cycles of a five-day period of the fasting mimicking diet, and may provide rationale for its use to treat uc.


Eligibility criteria:
inclusion criteria: * mild to moderate ulcerative colitis on the partial mayo score out of 9 (score between 2 to 7) * age of 18-70 at start of study (inclusive) exclusion criteria: * women who are pregnant or nursing or expect to be pregnant * individuals allergic to nuts * individuals with a body mass index (bmi) lower than 18 * individuals diagnosed with a serious medical condition as defined by the patient's physician, unless approved in writing by a physician * individuals who have been severely weakened by a disease or medical procedure, * individuals who are taking medication which may not be safely consumed with a calorie restricted diet * individuals with diabetes who are taking anti-diabetic drugs associated with risk of hypoglycemia * individuals with more than mild-moderate cardiovascular disease or life-threatening cancer (as determined by patient's physician) unless approved by a physician * individuals with history of severe cardiac disease (particularly uncompensated congestive heart failure nyha grade 2 or more or lvef \< 40%) * individuals with a history of syncope * individuals with dietary needs incompatible with the fmd meal plan * individuals with liver or kidney disorders that may be affected by very low glucose and protein content of the diet. * patients on a caloric restricted diet will also be excluded. * patients with relevant prior gastrointestinal surgery and consequences such as short bowel syndrome, ostomy of small or large intestine, hemi- or total colectomy, proctocolectomy, ileoanal pouch will be excluded.

Keywords: ulcerative colitis ibd diet fasting fasting mimicking diet uc intermittent fasting
effect of diet versus sleeve gastrectomy and gastric bypass on appetite

Conditions: Obesity

Summary: the biggest challenge in obesity management is maintaining weight loss in the long-term. currently, bariatric surgery is the most effective treatment, leading to sustained weight loss that is not yet achievable with lifestyle intervention (e.g. diet). the reasons behind its success is still not clearly understood, but beneficial changes in the homeostatic and hedonic appetite systems (the two major physiological regulators of appetite), along with the microbiome (known to have a mediatory effect on appetite) have been shown to occur after bariatric surgery. these alterations are in opposition to what is seen after diet-induced weight loss. today, the component of appetite regulation that drives bariatric surgeys' long-term success is still unknown. by comparing a lifestyle and surgical intervention in parallel, the investigators can observe the impact of a similar magnitude of weight loss on these three domains of appetite regulation simultaneously, thereby illuminating the mechanisms behind bariatric surgerys' success.


Eligibility criteria:
inclusion criteria: * scheduled for bariatric surgery * patient in obesity clinic * body mass index (bmi) 35-55 exclusion criteria: * currently taking medication known to affect energy metabolism or appetite * current cancer diagnosis * substance abuse * enrolled in another obesity treatment * eating disorders * pre-existing endocrine disorders (e.g. diabetes) will not be excluded, but final analysis will controlled for these conditions

Keywords: diet bariatric surgery appetite
effect of ras on balance and gait after stroke

Conditions: Stroke; Gait, Hemiplegic; Gait Disorders, Neurologic

Summary: a rhythmic auditory stimulation intervention may be beneficial in order to improve movement parameters after stroke. reviews argue that more randomized controlled trials with a control group are needed. main objective: evaluate the effect of a rhythmic auditory stimulation on the quality of balance and gait parameters in people with stroke. methodology: quasi-experimental study. the study has been approved by the hospital ethics committee.

a rhythmic auditory stimulation (ras) intervention may be beneficial in order to improve the parameters of the post-stroke movement: increase of the speed of the walk, improvement in the width of the step with the affected side, improvement of the walking index dynamics (dynamic gait index), improvement in cadence and improvement in the static balance. current systematic reviews argue that more randomized controlled trials with a control group are needed. main objective: to evaluate the effect of a rhythmic auditory stimulation on the quality of progress and balance in people with stroke. methodology: experimental group will be done between 2019 and 2020 and historical control group of the years 2017 and 2018. experimental group will do 3 sessions in a week of ras, and daily 2 hours of physiotherapy except of sundays. control group received 2 hours daily of physiotherapy, except sundays. the study has been approved by the hospital ethics committee.

Eligibility criteria:
inclusion criteria: * had a stroke in the last 3 weeks * rankin 3-4 * barthel before stroke: \>85 * tinetti \< 23 exclusion criteria: * patient can walk independently (functional ambulation category \>3) * global and/or mixed aphasia * glasgow \< 10 * mini-mental state examination \< 24 * posterior cerebral artery stroke * gait and/or balance disorders before stroke (parkinsons disease, neurodegenerative diseases)

Keywords: rhythm musicotherapy balance gait stroke physiotherapy
performance of the gynaecological examination in the lateral decubitus position

Conditions: Medical Care

Summary: the gynaecological examination consists of a breast examination, abdominal examination, inspection of the vulva, vaginal touch and pelvic examination with a speculum. the latter is essential for the insertion and removal of intrauterine devices (iuds), for the diagnosis and screening of pathologies that may cause pelvic symptoms, for assessment of the vaginal wall and for regular screening for cervical cancer. the gynaecological examination is feared by many women because of the feeling of exposure, vulnerability and loss of control. the parallel with a sexual position is particularly disturbing for patients who do not want to see this representation mixed with a medical necessity, which can lead some women to have irregular or even discontinued follow-up. for the past ten years, medical practice theses and midwifery dissertations have evaluated the interest of another position for the pelvic examination with the speculum : the lateral decubitus position in which the patient lies on her side. the lateral decubitus pelvic examination seems to be an alternative for comfort and respect for modesty, which is favoured by the patients. this examination position would have advantages in situations of anterior anatomical position of the position of the cervix, prolapse, severe obesity, hip pathology or significant reluctance to the examination. the effectiveness of this technique in terms of examination performance needs to be evaluated to promote its dissemination. the impact of an examination that is better experienced by patients is that of better adherence and therefore better follow-up, which is the particular challenge of primary care. single group: gynaecological examination in lateral decubitus, conventional repositioning if unsuccessful


Eligibility criteria:
inclusion criteria: * woman of legal age, 18 years or older. * who already had a gynaecological examination in the conventional position. * requiring a gynaecological consultation in primary care with speculum for screening, diagnosis or prevention. * woman of childbearing age with a negative urine pregnancy test or postmenopausal woman (no period in the last 12 months). * patient who has read and understood the information letter and signed the consent form. * affiliated to the social security. exclusion criteria: * pregnant woman * who already participated to this protocol * person deprived of liberty by an administrative or judicial decision or person placed under judicial protection / sub-guardianship or curatorship. * major cognitive impairment that prevents the subject from fully understanding the requirements for participation in the study or from giving informed consent