Kornimate/medical-research-clean huggingface dataset:
effect of core exercises on patellofemoral pain syndrome

Conditions: Patellofemoral Pain Syndrome

Summary: the goal of this interventional study is to investigate the effect of core strengthening exercises on pain, strength, function, and balance in patients with pfps.

purpose: patellofemoral pain syndrome is a frequent musculoskeletal disorder, which can result from core muscles instability that can lead to pain, function and altered dynamic balance. the objective of this study is to assess the effect of core muscle strengthening on pain, function, strength and dynamic balance in patients with patellofemoral pain syndrome. subjects and methods: forty-four patients with age ranging from 18 to 35 years with patellofemoral pain syndrome will be divided into study (n=22) and control (n=22) groups. both groups will be given 6 weeks of conventional physical therapy program and an additional core muscle strengthening for the study group. the tools are being used to assess the outcome are 1- visual analogue scale,2- handheld dynamometer,3-akps 4- biodex balance. hypotheses: it will be hypothesized that: 1. there is no effect of core strengthening exercises on pain in treating pfps. 2. there is no effect of core strengthening exercises on muscle strength in treating pfps. 3. there is no effect of core strengthening exercises on function in treating pfps.

Eligibility criteria:
inclusion criteria: 1. patients of both genders with an age range of 18- 35 years old. 2. gradual development of pain in the front of the knee lasting more than 12 weeks. 3. patients with body mass index 18- 25 kg m2. 4. pain is aggravated by at least 2 of the following activities: jumping, running, prolonged sitting, stair climbing, kneeling, and squatting. 1. positive patellar grinding test. 2. insidious onset of symptoms, unrelated to a traumatic damage. exclusion criteria: 1. traumatic patellar subluxation or dislocation. 2. a history of any of the following conditions: meniscal or other intra articular pathologic conditions; cruciate or collateral ligament involvement. 3. any lower limb bony or congenital deformities. 4. previous knee and hip joint surgeries. 5. osteoarthritis in the ankle, knee, or hip joints. 6. conditions that affect muscle strength such as diabetes mellitus or rheumatoid arthritis.

Keywords: core strengthening exercises, hip and knee-focused exercises, patellofemoral pain syndrome
development of a rapid and accurate diagnostic assay for tuberculosis

Conditions: Tuberculosis

Summary: this study evaluates new technique for diagnosis of tuberculosis. among patients who are suspected with tuberculosis, participants will be tested conventional method including xpert tb/rif assay, and new diagnostic technique using homobifunctionalimidoesters compounds.


Eligibility criteria:
inclusion criteria: * patients who are suspected with pulmonary tuberculosis, tuberculosis meningitis, tuberculosis peritonitis, tuberculosis pleurisy exclusion criteria: * under 18 years
to compare the efficacy of drugs in combination for treating irritable bowel syndrome associated with diarrhea

Conditions: Irritable Bowel Syndrome With Diarrhea

Summary: the goal of this clinical trial is to compare the efficacy of four different drugs in combination for management of irritable bowel syndrome (ibs)-associated diarrhea. the main question to answer is: * is there a significant difference in effect of different drug combinations in management of irritable bowel syndrome with diarrhea? participants will be divided into 3 treatment groups. * each group will be given a combination of drugs for 2 weeks * at the end of study, efficacy of different drug combinations and their potential side effects will be compared between the treatment groups

the goal of this clinical trial is to compare the efficacy of four different drugs (rifaximin , mebeverine, amitriptyline and psyllium husk) in combination for management of irritable bowel syndrome (ibs)-associated diarrhea. the main question to answer is: • is there a significant difference in effect of different drug combinations in management of irritable bowel syndrome with diarrhea? total of 162 participants will be enrolled in study. * participants will be divided into 3 treatment groups i.e. group a, group b and group c. * participants of group a will receive drug combination of rifaximin and mebeverine * participants of group b will receive drug combination of rifaximin and amitriptyline * participants of group c will receive drug combination of rifaximin and psyllium husk * each group will be given a combination of drugs for 2 weeks stool frequency, characteristic of stool and abdominal pain will be assessed at day 0 and day 14 of intervention data will be collected using questionnaire. questionnaire will be filled by the researcher spss will be used for analysis of data and appropriate test like chi square test, student t test and one way anova will be used to draw conclusions about the efficacy of different drug combinations and their potential side effects between the treatment groups

Eligibility criteria:
inclusion criteria: individual of both gender between the age of 18-50 years diagnosed case of irritable bowel syndrome associated with diarrhea exclusion criteria: * presence of co morbid diseases * coronary artery disease (cad) * chronic obstructive pulmonary disease (copd) * congestive heart failure (chf) * patients taking drugs which modify or aggravate symptoms of ibs (antidepressants, calcium channel blockers etc.) * patients having hyperthyroidism \& gluten hypersensitivity * patients with alarming symptoms, viz. history of fever, passage of blood in stool, loss of weight, any organic gastrointestinal disease in the recent past * patients with recent change in bowel habits, patients on any other concomitant medication for abdominal pain, bowel disturbance or altering gastrointestinal motility and malignancy of any other organ * patients with irritable bowel disease and celiac disease

Keywords: irritable bowel syndrome diarrhea ibs-d
exercise training study for patients with cystic fibrosis

Conditions: Cystic Fibrosis

Summary: the aim of this study is to test the effect of a 6-month program of self-regulated, home-based exercise with telephone reinforcement on the cardiorespiratory fitness, pulmonary function and health-related quality of life of children with cystic fibrosis (cf), compared to controls. exploring the exercise experiences of the children and parents is a secondary aim.

cf is a life-long illness that requires complex and dynamic adjustment by the patient and family. the nursing role is vital to the multidisciplinary team approach required in providing comprehensive, individualized care for these patients. nurses facilitate the coordination of health care efforts and support the patient and family across physical and psychosocial domains. with the well-documented correlation between exercise tolerance and both survival and hrqol, exercise represents a critical treatment focus for cf patients. nurses contribute to standard exercise rehabilitation programs, through education, psychosocial support, and communication. in this exercise training study, the nursing role will include: a) teaching the patients and families how to use the omni scale, b) confirming that they understand the home-based exercise regimen, and c) ensuring that the home-care program is properly followed by placing weekly telephone calls to assess progress and barriers. long-term nursing application will occur via dissemination of the omni training manual, to be developed as part of this study, for use by cf nurses in clinics worldwide.

Eligibility criteria:
inclusion criteria: * cf diagnosis * age 10-18 years * reliable pulmonary function tests * living at home * able to read * able to ride a stationary bike * able to walk and/or run on a treadmill. exclusion criteria: * enrolled in another intervention study * in structured aerobic activity for 30 continuous minutes 3 times per week * sibling enrolled in study.

Keywords: cystic fibrosis exercise perceived exertion aerobic fitness lung function health related quality of life self-regulated exercise
clinical investigation of the next-generation intraocular lens

Conditions: Cataract

Summary: this study is a 6-month, prospective, multicenter, bilateral, randomized clinical investigation of the tecnis model zhr00 and model zqr00 iols versus the tecnis symfony control iol. the study was conducted at 12 sites in the u.s.a and treated approximately 240 subjects, equally split between the two test groups and the control group.


Eligibility criteria:
inclusion criteria: * bilateral cataracts * potential for postoperative bcdva of 20/30 snellen or better * corneal astigmatism of 1.00 d or less in both eyes * normal corneal topography * clear intraocular media other than cataract in each eye * signed informed consent and hipaa authorization or equivalent documentation necessary to comply with applicable privacy laws pertaining to medical treatment in the governing countries exclusion criteria: * any clinically-significant pupil abnormalities (non-reactive, fixed pupils, or abnormally-shaped pupils) * irregular corneal astigmatism * inability to focus or fixate for prolonged periods of time (e.g., due to strabismus, nystagmus, etc.) * prior corneal refractive (lasik, lasek, rk, prk, etc.) or intraocular surgery * corneal abnormalities such as stromal, epithelial or endothelial dystrophies that are predicted to cause visual acuity losses to a level worse than 20/30 snellen during the study * inability to achieve keratometric stability for contact lens wearers * recent ocular trauma or ocular surgery that is not resolved/stable or may affect visual outcomes or increase risk to the subject * subjects with diagnosed degenerative visual disorders * subjects with conditions associated with increased risk of zonular rupture, including capsular or zonular abnormalities that may lead to iol decentration or tilt, such as pseudoexfoliation, trauma, or posterior capsule defects * use of systemic or ocular medications that may affect vision * prior, current, or anticipated use of tamsulosin or silodosin * poorly-controlled diabetes * acute, chronic, or uncontrolled systemic or ocular disease or illness * known ocular disease or pathology that may affect visual acuity or may require surgical intervention during the course of the study or may be expected to require retinal laser treatment or other surgical intervention during the course of the study * patient is pregnant, plans to become pregnant, is lactating or has another condition associated with the fluctuation of hormones that could lead to refractive changes * concurrent participation or participation within 45 days prior to preoperative visit in any other clinical trial * desire for monovision correction
a study to assess the safety, tolerability and effect of nexagon™ applied to the eye after prk laser eye surgery for nearsightedness

Conditions: Corneal re-Epithelialization

Summary: phase 1 randomized, prospective, double-masked, vehicle-controlled, dose-escalation study to evaluate the safety, tolerability and clinical effect of nexagon™ in subjects following bilateral prk for the correction of mild to moderate myopia.


Eligibility criteria:
inclusion criteria: * male or female pre-presbyopic myopes. * aged between 20 and 50 years inclusive. * females are eligible to participate only if they are currently non-pregnant and non-lactating. females of child-bearing potential must commit to consistent and correct use of an acceptable method of birth control. * subjects willing and able to undergo bilateral prk for the correction of their myopia. * subjects with mrse \<6.0 d, with less than 2.0 d of astigmatism. * no more than 1.0 d of refractive difference between eyes. * stable prescription in both eyes as defined by \<0.25 d change over the preceding 2 years. * subjects who are able to comply with all study procedures, including wearing a soft bandage contact lens in the immediate postoperative period. * subjects who are willing and able to give written informed consent to take part in the study. exclusion criteria: * subjects who have a past or present disease, which as judged by the investigator may affect the safety of the subject or the outcome of the study. * subjects who have previously had corneal surgery. * subjects who require mitomycin c following their prk. * subjects with any ocular disease or corneal abnormality, including but not limited to: * decreased corneal sensation / neurotrophic cornea; * corneal vascularization; * keratoconus; * keratoconjunctivitis sicca requiring chronic treatment; * lagophthalmos; * blepharitis; * history of infectious keratitis; * history of glaucoma or intraocular pressure of \>21 mmhg or use of glaucoma medications; * significant dry eye disease that requires regular topical treatment; * corneal thickness \<480 µm at the thinnest point, and * posterior elevation \>40 mmhg. * subjects with corneal haze \>+1 as assessed using the grading scale in the protocol. * subjects who require any topical ophthalmic medication other than the pre- and postoperative regimen defined in the study protocol. * subjects with: * diabetes; * collagen disorders associated with autoimmune diseases, e.g., lupus, rheumatoid arthritis; * severe atopic disease; * any systemic disease or condition where the subject is immunocompromized. * subjects who require any systemic medication that affects healing, e.g., steroids, hormone replacement therapy. * subjects who are taking amiodarone, long acting anticholinergics, e.g., atropine, scopolamine, or medications or agents that can cause dry eye. * subjects who have participated in a clinical trial within the 30 days prior to the date on which prk is scheduled.

Keywords: photorefractive keratectomy re-epithelialization nexagon prk coda
a phase iv-pharmacovigilance study of keppra greece - s.k.a.t.e.: safety of keppra as adjunctive therapy in epilepsy

Conditions: Epilepsy

Summary: patients in community-based practices correspond to the 25% of patients who need a first add-on drug when not controlled by their standard monotherapy drug. this was a therapeutic use trial in which the population corresponds more closely to that seen in daily clinical practice.


Eligibility criteria:
inclusion criteria: * partial onset seizures with or without secondary generalisation with epilepsy. exclusion criteria: * hypersensitivity to levetiracetam or other pyrrolidone derivatives or to any of the excipients.

Keywords: levetiracetam keppra
cold water immersion modulates reinforcing effects of nitrous oxide - 2

Conditions: Opioid-Related Disorders; Substance-Related Disorders

Summary: the purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. to evaluate: cold water immersion modulates the reinforcing effects of nitrous oxide in healthy volunteers.


Eligibility criteria:
please contact site for information.

Keywords: nitrous oxide choice subjective effects pain analgesia reinforcer healthy volunteer
online hemodiafiltration versus hemodialysis in removal of indoxyl sulfate in chronic hemodialysis patients

Conditions: Hemodialysis

Summary: this study aimed to compare the removal of indoxyl sulphate between hemodiafiltration, high flux hemodialysis and low flux hemodialysis


Eligibility criteria:
inclusion criteria: * maintenance hemodialysis patients aged more than 18 years exclusion criteria: * active illnesses, hospitalization, malignancy
video-based counseling & rapid hiv testing for teens

Conditions: HIV; HIV Infections

Summary: this study evaluated the educational effectiveness of a youth-friendly pre-test video (derived from a previous qualitative study) and compared it with in-person hiv pre-test counseling. a convenience sample of 200 medically stable individuals between the ages of 15 and 21 presenting to an urban ed were recruited to participate in this study and randomized into 2 groups. individuals were eligible if they were english-speaking, sexually active and able to consent. all participants completed a sexual risk factor and demographic survey. group 1 completed a validated pre-test knowledge measure, viewed the hiv education video then completed a post-test knowledge measure. group 2 completed the same knowledge measures, but received pre-test hiv counseling from a trained public health advocate. hiv testing was optional


Eligibility criteria:
inclusion criteria: * 15-21 year old * sexually active * english-speaking exclusion criteria: * medically unstable

Keywords: hiv hiv knowledge measure teen hiv testing hiv seronegativity
a clinical investigation of the copeland™ humeral resurfacing head

Conditions: Osteoarthritis; Rheumatoid Arthritis; Avascular Necrosis; Humeral Fractures

Summary: the purpose of this study is to perform a five-year, prospective evaluation of the copeland™ humeral resurfacing head prosthesis for outcome and durability. relief of pain and restoration of function will determine long-term clinical outcome while durability will be measured by the absence of revisions.


Eligibility criteria:
inclusion criteria: * non-inflammatory degenerative joint disease including osteoarthritis and avascular necrosis. * rheumatoid arthritis * correction of functional deformity * reconstructable rotator cuff * treatment of acute fracture of the humeral head * traumatic arthritis exclusion criteria: * patients less than 18 years. * patients with rapid joint destruction, osteomalacia, osteoporosis, or marked bone loss, which would preclude proper fixation of the prosthesis. * patients with marked bone loss apparent on roentgenogram. * metabolic disorders, which may impair bone formation. * patients who are pregnant. * patients with an active or suspected infection in or around the shoulder or distant foci of infections, which may spread to the implant site. * patients with severe instability or deformity of the ligaments and/or surrounding soft tissue, which would prelude stability of the prosthesis. * patients who have had revision procedures where other devices or treatments have failed. * patients with a highly communicable disease or diseases that may limit follow-up (e.g. immuno-compromised conditions, hepatitis, active tuberculosis, neoplastic disease, etc). * patients unwilling or unable to comply with a rehabilitation program for a cemented or cementless partial or total shoulder replacement or who indicate difficulty or inability to return for follow-up visits prescribed by the study protocol. * patients with previous shoulder surgery or conditions that may interfere with the partial or total shoulder replacement's survival or outcome. * patients who qualify for inclusion in the study, but refuse consent to participate in the study. * patients who have had a partial or total shoulder arthroplasty on the contralateral shoulder within the last year.

Keywords: fractured humeral head traumatic arthritis resurfacing shoulder shoulder replacement shoulder arthritis
genomics in michigan impacting observation or radiation

Conditions: Prostate Cancer

Summary: to determine the impact of decipher test results on adjuvant treatment decisions of high-risk post-rp patients with undetectable post-op prostate specific antigen (psa) compared to clinical factors alone.

this prospective, randomized trial will compare the receipt of adjuvant therapy for high-risk radical prostatectomy (rp) patients who undergo decipher testing to those who do not. 350 subjects from within the statewide michigan urological surgery improvement collaborative (music) will be randomized to either a genomic classifier (decipher) or usual-care-based (uc) strategy for a period of three months. if enrolled during the genomic classifier period, both subjects and their treating physician will be provided decipher results and capra-s scores. in the uc periods, capra-s scores but not decipher results will be provided. the enrollment goal, initially and throughout the study, was to enroll 350 evaluable patients. during the study, the target accrual goal was raised to 550 patients to allow more flexibility among sites to achieve the enrollment goal of 350 evaluable patients.

Eligibility criteria:
inclusion criteria: * prostate cancer patients who have undergone radical prostatectomy * psa \< 0.1 ng/ml at enrollment * at least one of the following: * pt3 (seminal vesicle invasion or extraprostatic extension), or * positive surgical margins * radical prostatectomy within one year of enrollment exclusion criteria: * individuals who have any of the following will not be eligible to participate: * have regional or distant metastatic disease * received any radiation or hormone therapy (neo-adjuvant, adjuvant, or salvage) * node positive

Keywords: genomics adjuvant treatment
the influences of watching a movie clip of normal walking on measurable walking parameters among post-brain-stroke patients as opposed to the influences of a control movie clip showing backwards walking

Conditions: Stroke

Summary: the study will include 20 subjects who will be randomly divided to two groups: a ten person group being the study group and a ten person group acting as a control group (each group will include a similar number of females and males as the other group). in addition, the physiotherapy treatments at the rehabilitation center, the study group will gain an intervention consisting of 12 therapy sessions, administered for 12 consecutive days (apart of weekends). the intervention will include 6 minutes of watching a movie clip alternately showing a healthy man and a healthy woman at their sixties, walking while being filmed from various angles. immediately after watching, the subject will perform 6 minutes of walking, under the experimenters supervision, but without his or hers intervention. immediately following the walking, the whole procedure will be repeated (watching a clip and walking). the control group will undergo 12 treatments of the same nature, but will watch the movie clip shown backwards, so that the people filmed will seem to walk backwards (it was established that watching a reversed action does not activate the mns system activated by a regular execution of the activity \[celnik et al., 2008\]), followed by 6 minutes of walking under the experimenters supervision, then watching the movie again and walking again. the person performing the examinations will be blinded as to the division of the subjects to the study group and the control group. after performing the previously noted examinations needed to participate in the research, the subjects found fit will be examined before the beginning of the intervention, at its end and then three months after its conclusion. the examinations will include smart step and walking parameters.


Eligibility criteria:
inclusion criteria: * people after a first ischemic or hemorrhagic stroke, up to 60 days following the event. * a fac (functional ambulation category) score test result of 2 or 3, in order to ensure basic mobility, even if still requiring supervision. * a nihss (national institutes of health stroke scale) score of 3 to 18. * patients suffering from the following will not be part of the study: * significant neglect (a bit score under 129 in the conventional tests). * hemianopsy as determined upon a clinical examination by a rehabilitation physician. * clarity of vision problem, determined upon an sc based examination. * significant cognitive decline (a mini mental test score of under 24). * aphasia which prevents understanding the signing a helsinki form. exclusion criteria: * patients participating in concurrent researches will not participate