Kornimate/medical-research-clean huggingface dataset:
hybrid blood pressure monitor validation

Conditions: Essential Hypertension

Summary: assessment of the accuracy of a blood pressure measuring device with a digital display-column, nissei dm 3000, according to an adaptation of the "european society of hypertension international protocol revision 2010 for the validation of blood pressure measuring devices in adults".

according to the "european society of hypertension international protocol revision 2010 for the validation of blood pressure measuring devices in adults", 33 patients have their blood pressure measured by two observers using parallel connected mercury sphygmomanometers, blinded from each other's result, and then by the supervisor using the tested device, nissei dm 3000. the measurements using the mercury sphygmomanometers are repeated 5 times and in between them, 4 measurements using the tested device take place. if the results of the comparison of these measurements according to the analysis required by the protocol, meet the required criteria, the device is regarded as "pass", otherwise as "fail". in this study, instead of consecutive, simultaneous measurements of the two mercury sphygmomanometers and tha tested device will be taking place. this will be so to exclude any inaccuracy due to blood pressure variability and because the tested device has a controllable deflation rate and allows simultaneous measurements with the mercury sphygmomanometers. in addition, the investigators will be performing 6 set of measurements instead of 4.

Eligibility criteria:
inclusion criteria: * above 25 years of age * sinus rhythm * informed consent exclusion criteria: * sustained arrhythmia * pregnancy * poor quality korotkoff sounds * unavailable cuff size * completed blood pressure range (according to protocol)

Keywords: blood pressure measuring devices essential hypertension automated blood pressure measurement
salivary evaluation in healthy volunteers

Conditions: Healthy; Salivary Gland Disease

Summary: saliva is critical in maintaining oral health and comfort. our laboratory has investigated several disorders of salivary glands. the purpose of this protocol is to obtain data from healthy volunteers for comparison with data from patients with salivary dysfunction. we plan to utilize the nih clinical center clinical research volunteer program to solicit paid participation from healthy adults. study procedures are accomplished in 2-3 outpatient visits that include an interview, saliva collection, lip biopsy, clinical laboratory studies, dry eye examination, and lip biopsy follow up, as needed. these are routine diagnostic procedures. biopsy specimens may be used in clinical and laboratory studies, such as in vitro biochemical analysis or in vivo transplantation. some of the healthy volunteers may be asked to participate in an mri study of the salivary glands.

* objective: to obtain data from healthy volunteers for comparison with data from patients with salivary dysfunction. * study population: healthy volunteers aged 18-70 years old * design: observational * outcome measures: clinical and basic science data to serve as controls for comparisons with subjects presenting with salivary gland dysfunction saliva is critical in maintaining oral health and comfort. our laboratory has investigated several disorders of salivary glands. the purpose of this protocol is to obtain data from healthy volunteers for comparison with data from patients with salivary dysfunction. we plan to utilize the nih clinical center clinical research volunteer program to solicit paid participation from healthy adults. study procedures are accomplished in 2-3 outpatient visits that include an interview, saliva collection, lip biopsy, clinical laboratory studies, dry eye examination, and lip biopsy follow up, as needed. these are routine diagnostic procedures. biopsy specimens may be used in clinical and laboratory studies, such as in vitro biochemical analysis or in vivo transplantation. some of the healthy volunteers may be asked to participate in an mri study of the salivary glands. the outcome measurement for this study is to determine those healthy subjects whose data and specimens can be used as control comparison for our patient subjects in our sj(sqrroot)(delta)gren s syndrome studies (15-d-0051, 99-d-0070, 11-d-0094 and/or 11-d-0172).

Eligibility criteria:
* inclusion criteria: * healthy male or female volunteers from 18 to 70 years old. * ability to understand and sign an informed consent document. exclusion criteria: * known pregnancy. * chronic medical illness, other than well-controlled hypertension or hyperlipidemia. * chronic use of medications, with the exception of oral contraceptives, hormone replacement therapy, antihypertensives and antilipemics. * have problems with dry mouth and/or dry eyes. * nih employees who are subordinates/relatives/co-workers of investigators.

Keywords: saliva parotid lip biopsy health exocrine normal volunteer
a study of bms-863233 in patients with hematologic cancer

Conditions: Refractory Hematologic Cancer

Summary: to determine safety, tolerability and maximum tolerated dose of bms-63233/xl413 in subjects with refractory hematologic cancer


Eligibility criteria:
inclusion criteria: * aml by current who diagnostic criteria, any fab type (except apml), refractory all, accelerated/blast phase cml and refractory mds with total ipss score of 2 or higher * ecog performance status \<= 2 * accessible for treatment, pk sample collection and required study follow-up * total bilirubin ≤ 1.5 x uln and alt, ast ≤ 3 x uln exclusion criteria: * women who are pregnant or breastfeeding * subjects with acute promyelocytic leukemia disease or cns leukemia disease) * hyperleukocytosis (defined as peripheral wbc \>50,000/ul) * treatment with any other investigational agent for any indication within 30 days of protocol enrollment * subjects a history of gastrointestinal disease * subjects less than four weeks from allogenic or autologous stem cell transplant infusion
does a phone-based meditation application improve mental wellness in emergency medicine personnel?

Conditions: Burnout, Professional; Depression; Anxiety; Stress

Summary: emergency medicine is notorious for its high rate of burnout and mental health issues. the emergency department (ed) is a high paced work environment dealing with life and death issues. employees in the ed work shift times that are not conducive to a natural circadian rhythm. all of these factors lead to high rates of burnout and overall dissatisfaction with their career choice. these are known downsides of a career in emergency medicine, but little effort is put into addressing this issue in everyday eds. cell phones offer an easy and convenient means to participate in meditation. there are multiple evidence-based meditation apps available to cell phone users free of charge. meditation has been shown to decrease burnout, rates of depression, and rates of anxiety. we hypothesize that weekly use of a meditation-based cell phone application will improve the mental health of emergency department employees as measured on various wellness inventories.


Eligibility criteria:
inclusion criteria: * employment in the emergency department (with at least 8 shifts a month at dell seton medical center or seton medical center) as either an attending physician, resident physician, or nurse * age greater than/equal to 18 years old and younger than 75 years old * must own a mobile phone operating on the ios system exclusion criteria: * already use a phone-based meditation app on a weekly basis * currently undergoing psychological treatment in the form of weekly therapy or psychotropic medications
quantitative imaging metrics from cect in measuring disease response or progression in patients with kidney cancer

Conditions: Renal Cell Carcinoma

Summary: this pilot research trial studies quantitative imaging metrics derived from contrast enhanced computed tomography (cect) in enhancing assessment of disease status in patients with kidney cancer. quantitative imaging is the extraction of quantifiable features from radiological images for the assessment of disease status. collecting quantitative imaging metrics from cect imaging may help doctors predict tumor aggressiveness and nuclear grade (tumor stage) and assess treatment response and prognosis in cancer imaging.

primary objectives: i. to investigate the role of quantitative imaging metrics (qim) as a potential diagnostic biomarker. ii. to investigate if qim parameters can differentiate clear cell renal cell carcinoma (rcc) from papillary rcc. iii. to evaluate the tumor grade of the target lesion as assessed by qim from cect for agreement with the pathological (fuhrman) grade. iv. to investigate the role of qim as a potential prognostic biomarker. v. to develop a novel method of calculating renal tumor contact surface area (csa) using advanced image-processing technology (matlab®, 3 dimension \[d\] synapse) and predict peri-operative variables such as blood loss, operative time and post-operative estimated glomerular filtration rate (egfr) in patients undergoing partial nephrectomy (pn). vi. to develop qim that would help in predicting postoperative functional outcomes such as predicted surgically resected volume and postoperative glomerular filtration rate (gfr). outline: patients' clinical and imaging data are collected from routine multiphase cect imaging and used to establish and validate the classification/prediction rule for qim.

Eligibility criteria:
inclusion criteria: * subjects with a renal mass who are scheduled for surgery for presumed rcc * subjects scheduled for standard of care contrast enhanced ct examination at usc norris comprehensive cancer center * subjects competent to sign study specific written informed consent exclusion criteria: * subjects who are pregnant * subjects who cannot consent for themselves
effects of workplace intervention in occupational rehabilitation on return to work

Conditions: Mental Disorders; Musculoskeletal Diseases; Fatigue Syndrome, Chronic

Summary: aim is to study the effect of a work place intervention during a multicomponent return-to-work rehabilitation program on return-to-work. the intervention is compared with inpatient rehabilitation only, and participants will be recruited from the diagnostic groups dominating the sick-leave statistics, namely musculoskeletal disorders, common mental disorders (e.g. stress, depression and anxiety), and unspecific disorders including chronic fatigue.

long-term sick-listing from work has considerable impact on social function, on the families of the sick-listed persons, the companies they work for, and society as a whole. hence, the need for documented effective vocational rehabilitation programs is pressing. vocational rehabilitation services described in the scientific literature have been specific to one single or a specific group of medical conditions (e.g.low back pain). in contrast, most people on sick leave have several health complaints, and many of the factors influencing sick leave are shared regardless of disorder (e.g. social surroundings, workplace environment), calling for rehabilitation programs that can be employed for both musculoskeletal, unspecific and common mental disorders. research indicates that interventions on the work place might facilitate return to work. the aim of this study is therefore to investigate the effect of a work place intervention during a multicomponent return-to-work rehabilitation program on return-to-work.

Eligibility criteria:
inclusion criteria: * resident of central norway * sick-listed due to common mental disorders, musculoskeletal pain/problems, unspecific disorders and/or fatigue * sick-listed more than 50 % * sick-listed longer than 8 weeks * has employer and is willing to participate in a work place intervention during the rehabilitation program exclusion criteria: * is self-employed * has, or is currently examined for, a serious somatic or psychiatric disorder * suffers from substance abuse * has trouble with participating in a group * is in a rehabilitation process that will interfere with the occupational rehabilitation program * function level is to weak to participate in the rehabilitation program

Keywords: rehabilitation return to work
myofunctional therapy in open bite - rct

Conditions: Open Bite

Summary: the goal of this clinical trial is to learn if myofunctional therapy in 6-10-year-old children with infant type of swallowing and open bite is effective. primary hypothesis: myofunctional therapy results in correction of open bite researchers will compare a group in which myofunctional therapy is performed for 6 months to a group in which myoufunctional therapy will be delayed by 1 year. participants will exercise according to a pre-established regimen and schedule


Eligibility criteria:
inclusion criteria: * generally healthy children aged 6-10 years, * infant swallowing type, * open anterior occlusion (i.e. no contact between the maxillary and mandibular medial incisors), * mixed dentition exclusion criteria: * finger sucking habit (or similar) occurring within the last 6 months, * previous myofunctional therapy, * upper airway obstruction, * congenital craniofacial developmental disorder, * connective tissue or muscle disease, * macroglossia, * ankyloglossia, * mental retardation

Keywords: open bite child myofunctional myotherapy exercises
inertial sensors for obstetrical walking epidural tracking

Conditions: Pregnancy Related; Epidural; Anesthesia, Headache; Labor Complication

Summary: freedom of movement and the ability to walk are crucial during the first stage of labor, potentially reducing labor duration, cesarean section risk, epidural analgesia use, and bladder catheterization. while the clinical effects of ambulation during labor remain controversial, there is a consensus on its positive impact on the birthing experience and satisfaction. epidural analgesia remains the gold standard for pain control during labor, with a utilization rate of 82% in france. recent advancements in obstetric analgesia have allowed for lower doses of analgesics, often administered via patient-controlled analgesia, which maintains the potential for ambulation during labor. however, only a small number of maternity units in france offer this technique. the main barriers include organizational issues such as unsuitable facilities, lack of wireless telemetry, and potential risks such as falls and hypotension. significant changes in gait characteristics are observed throughout pregnancy, particularly during the third trimester, and are studied in laboratory settings using video capture and analysis. gait during labor is influenced by pain, fetal progression, and anatomical changes in the pelvis. the presence of epidural analgesia, where local anesthetics likely affect neural transmission, may impact motor commands and sensory feedback, further altering gait characteristics. these biomechanical aspects of labor remain understudied. wearable inertial sensors show promise in maternal health monitoring by providing real-time data for motion and gait studies. however, their application has not been described or validated during labor, particularly in walking conditions. continuous dynamic study of gait in these conditions could enable non-invasive, non-intrusive monitoring of analgesia effectiveness, fall risk prediction, and labor progression analysis. the aim of this feasibility study is to validate the use of wearable inertial sensors to quantify movements and characterize gait during the first stage of labor, both with and without low-dose epidural analgesia.


Eligibility criteria:
inclusion criteria: * pregnancy \>= 38 gestation weeks * no significant medical history (american society of anesthesiologists class asa 1) * receiving low-dose epidural analgesia with ambulation (in accordance with current service protocol) * not opposed to the study exclusion criteria: * refusal to participate in this study * non-french-speaking patient * history of osteoarticular pathology likely to change gate (severe scoliosis, spinal surgery, congenital hip deformity, pelvic fracture, ligament or knee joint pathology) * adults under legal protection * multiple pregnancy * need for continuous intravenous infusion with infusion stand during ambulation

Keywords: pregnancy labor epidural analgesia walking epidural movements gait inertial sensor
a study to compare the efficacy and safety of lisocabtagene maraleucel vs investigator's choice options in adult participants with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma, whose disease has failed treatment with both btki and bcl2i therapies

Conditions: Leukemia, Lymphocytic, Chronic, B-Cell

Summary: the purpose of this study is to compare the efficacy and safety of liso-cel vs investigator's choice options (idelalisib + rituximab or bendamustine + rituximab) in adult participants with r/r cll or sll, whose disease has failed treatment with both btki and bcl2i targeted therapies.


Eligibility criteria:
inclusion criteria * must have what doctors call measurable disease, which will be evaluated before each participant take part of the study. * must have received both a btki and a bcl2i treatment, and their disease must have come back or not responded to treatment, or they must not have been able to tolerate the side-effects of the btki and/or bcl2i treatment(s). * must also have an ecog performance score of 0 or 1, which means they are able to carry out their normal daily activities without any problems. exclusion criteria * heart problems. * bleeding disorders. * active cancer in their brain. * other reasons include:. i) having certain treatments in the past. ii) having certain infections that are not under control. iii) having certain brain conditions. - other protocol-defined inclusion/exclusion criteria apply.

Keywords: small lymphocytic lymphoma b cell malignancies cd19+ b cell malignancies non-hodgkin lymphoma
study of feasibility to reliably measure functional abilities' changes in nonambulant neuromuscular patients without trial site visiting

Conditions: Spinal Muscular Atrophy; Neuromuscular Disorders

Summary: clinical trials organization in several neuromuscular disorders (nmd) has some specific issues. nonambulant status and difficulties with transportation are among them. moreover a lot of patients with nmd have so poor condition that even short transportation is able to worse it. such situation forces researchers to limit a region of recruitment for clinical trials and to exclude from trials more severe subgroup of patients, which cause additional issues especially for rare diseases. the purpose of this study is to prove hypothesis about possibility to reliably monitor patient condition remotely, without trial site visiting. visit-free study design is potentially able to widen eligible patient population and to decrease patient dropout rate as well as burden of numerous assessments. meanwhile assessment frequency could be increased enabling monitoring of short fluctuations in patients' condition. spinal muscular atrophy (sma) is a rare neuromuscular condition to which all mentioned above issues are completely applicable. direct current stimulation (dcs) of neural structures is well studied and safe intervention, however, its effects on sma patients' strength and durability has not been reported for today. the investigators suppose that investigation of dcs action in sma patient population is an adequate model for visit-free design feasibility, reliability and sensitivity evaluation.


Eligibility criteria:
inclusion criteria: * signed informed consent * 5q sma confirmed by molecular testing exclusion criteria: * need for ventilation * hypersensitivity (pain or allergic reaction) to current stimulation

Keywords: spinal muscular atrophy neuromuscular disorders outcome measures visit-free clinical trial design
diving for post traumatic stress disorder (ptsd)

Conditions: Ptsd

Summary: within the components of scuba diving there are similarities with meditation and mindfulness techniques. ptsd and emotion dysregulation are known to be involved by meditation training this study evaluates the benefits of scuba diving on quality of life and mindful functioning comparing the benefits of diving training using a clinical trial protocol


Eligibility criteria:
inclusion criteria: * ptsd exclusion criteria: * mindfulness practice
elo water in diabetes care for enhancement of blood sugar control

Conditions: Diabetes Mellitus

Summary: this double-blinded, randomised and controlled trial evaluates the efficacy of oxygen-enriched elo drinking water as an adjuvant modality in diabetes care for enhancement of glycemic control in patients with type 2 diabetes mellitus. adults with type 2 diabetes will be randomized to drink 1.5 l of either elo water or normal drinking water for 24 weeks. the primary outcome is improvement in glycaemic control.

global diabetes mellitus prevalence is rapidly increasing. in 2015, idf reported that singapore has 12.8% of its population diagnosed with diabetes mellitus, of which more than 90 percent are type 2 diabetes with underlying insulin resistance. with the aging population and increasing prevalence of obesity and sedentary lifestyles, the prevalence is expected to continue to rise. in vitro studies demonstrated that hypoxia creates a state of insulin resistance through hif (hypoxia inducible factor) transcription factor expression in adipocytes. insulin sensitivity was shown to improve in type 2 diabetes patients and overweight non diabetic patients placed in a hyperbaric oxygen chamber.increased water intake has been associated with lower hba1c in the general population , and also with lower post-prandial glucose in type 2 diabetic individuals. this study aims to evaluate the effects of 1.5 l daily of elo water, a drinking water enriched with molecular oxygen in a stable form, with a similar volume of bottled drinking water, on glycaemic control in adults with type 2 diabetes in singapore.

Eligibility criteria:
inclusion criteria: type 2 diabetes mellitus with hba1c 8.0% to 11%, within the last 6 months exclusion criteria: 1. type 1 diabetes patients 2. pregnant or lactating women 3. comorbid conditions requiring fluid restriction to below 1.5 l daily 4. terminal illness with life expectancy less than 1 year

Keywords: oxygen-enriched water