Kornimate/medical-research-clean huggingface dataset:
fluorescence-guided surgery using crgd-zw800-1 in oral cancer

Conditions: Squamous Cell Carcinoma of the Head and Neck; Oral Cancer; Squamous Cell Carcinoma of the Oral Cavity

Summary: this is a two-staged clinical trial to investigate the feasibility of intraoperative fluorescence imaging (fli) to adequately assess tumor margins in patients with oral cancer using crgd-zw800-1.

work package i: in wp-i, the preferred dose of the agent for imaging of margins in oral cancer will be determined. the signal-to-noise ratio will be determined in dose group a (n=7), which will receive 0.05 mg/kg of the tracer, 16-20 hours before surgery. after an interim evaluation of this ratio, the second dose group b (n=7) will receive either a higher or a lower dosage (to be determined) of the tracer. after inclusion of all patients (n=14), the dose with the highest intraoperative signal-to-noise ratio will be selected. work package ii: in wp-ii, an expansion cohort (n=14) will be added to the group of patients that had received the selected dose in wp-i. in this group of 21 patients, it will be determined if fli can improve the rate of adequate surgical resection margins. as secondary research questions, the following aspects will be assessed: * sensitivity, specificity, positive and negative predictive values of fli; * colocalization with immunohistochemistry; * change in surgical management; incremental operation time; * fli of excised cervical lymph nodes.

Eligibility criteria:
inclusion criteria: 1. patients with biopsy-proven squamous cell carcinoma of the oral cavity, eligible for surgical resection of the primary tumor; 2. ≥ 18 years of age; 3. before patient registration, written informed consent must be given according to ich/gcp, and national/local regulations; 4. screening ecg and clinical laboratory test results are within normal limits, or if any are outside of normal limits they are considered to be clinically insignificant. exclusion criteria: 1. previous surgery, chemotherapy or radiotherapy to the oral cavity; 2. history of a clinically significant allergy or anaphylactic reactions to any of the components of the agent. 3. patients pregnant or breastfeeding, lack of effective contraception in male or female patients with reproductive potential; 4. patients with renal insufficiency (egfr\<60); 5. patients with a previous kidney transplantation in the medical history; 6. immuno-compromised patients who do not have the ability to respond normally to an infection due to an impaired on weakened immune system, caused by either a pre-existing disease or concomitant medications; 7. any condition that the investigator considers to be potentially jeopardizing the patient's well-being or the study objectives.

Keywords: crgd-zw800-1 fluorescence-guided surgery image-guided surgery fluorescence imaging cancer
the efficacy and safety of periocular acupoint stimulation on myopia progression in children

Conditions: Myopia

Summary: myopia is widely one of the three commonly detected refractive errors. myopia is usually managed by correction through glasses or contact lenses. other alternative available include surgery, drugs and acupuncture. there are various therapeutic approaches and different points can be used in acupuncture treatment for myopia, such as auricular acupuncture, acupressure body acupuncture. however, the mechanism of acupuncture therapy for myopia is largely unknown. furthermore, little information exists regarding the effects and safety of acupuncture for degenerative myopia in children. the investigators aimed to assess the overall effectiveness, safety of periocular acupressure for children with myopia the hypotheses of this study are as follows: periocular acupressure is effective for myopia progression delay. the study aims to include 56 participants.


Eligibility criteria:
inclusion criteria: * aged 7-12 years * spherical equivalent greater than -5d * individuals without strabismus, anistopia * willingness to participate in the study exclusion criteria: * the presence of a related disease such as cataract, glaucoma, or other eye disease. * individuals who were received ocular or scalp trauma. * individuals who were received ocular surgery and had ocular wound. * individuals who were adapted bifocal lense. * individuals suffering fever or bad conditions. * individuals suffering systemic or neurologic disease. * indibiduals who were receiving other therapy during the period of study * individuals who did not comply with the treatment which affected myopia progression.

Keywords: myopia children acupressure refractive error axial length korean medicine
using continuous positive airway pressure to reduce the incidence of acute kidney injury in hospitalized patients with chronic kidney disease

Conditions: Chronic Kidney Disease; Obstructive Sleep Apnea

Summary: obstructive sleep apnea (osa) is a common and undertreated condition in patients with chronic kidney disease (ckd). both physiologic and empiric data suggest that renal hypoxia due to osa is associated with worsening kidney function. hospitalized patients are often exposed to multiple nephrotoxins such as antibiotics, contrast agents, and diuretics, which place them at risk for acute worsening of kidney function. this study aims to determine whether immediate diagnosis and treatment of osa in ckd patients will decrease the incidence of acute kidney injury during hospitalization. the investigators will evaluate the extent to which this effect can be attributed to a decrease in nocturnal hypoxia and improved blood pressure control. secondary endpoints include hospital length of stay, and a composite outcome comprised of hemodialysis initiation, major cardiovascular events, and mortality.


Eligibility criteria:
inclusion criteria: 1. ckd defined by national kidney foundation staging system: egfr \< 60 2. overnight sleep study consistent with osa exclusion criteria: 1. currently treated with positive airway pressure for sleep-disordered breathing 2. hemodynamically unstable, defined as sbp \< 90, or use of vasopressors 3. intubated or mechanically ventilated 4. respiratory insufficiency, defined as p/f ratio \< 250, or requiring mechanical ventilation 5. end stage renal disease on renal replacement therapy 6. contraindication to cpap, including active emesis, recent intracranial surgery, altered level of consciousness

Keywords: chronic kidney disease, acute kidney injury, obstructive sleep apnea
the impact of gut microbiota in anastomoses insufficiency after resection and direct anastomosis for colorectal cancer.

Conditions: Colorectal Cancer, Peritoneal Carcinomatosis, Anastomosis Insufficiency

Summary: the role of gut microbiota in anastomosis insufficiency in patients operated for colorectal cancer and for peritoneal carcinomatosis is going to be investigated. this is a pilot study.


Eligibility criteria:
inclusion criteria colorectal group * adenocarcinom in colon or rektum * curative operation planed * direct anastomose plan * elective surgery inclusion criteria hipec group : * all patients with appendix, colon or rectal cancer accepted for crs+hipec exclusion criteria: * ongoing antibiotics treatment * antibiotics treatment in the last 6 months * acute surgery * palliative surgery * ulcerös colitis or crohns disease * prior colectomy * small intestine stoma before the operation * neoadjuvant treatment * colon preparation
evaluation of the ez blocker

Conditions: Intubation; Thoracic Surgery; One-lung Ventilation

Summary: in anesthetized patients the airway needs to be secured due to lack of protective reflexes. golden standard is the endotracheal intubation. in patients undergoing lung surgery single lung ventilation is essential. in these cases a double lume tube is commonly used. the double lume tube has a proximal tracheal and a distal bronchial end reaching into the left or the right side of the lung dependant of the model of the tube. thus it is possible to operate on one collapsed side of the lung while ventilating the other side. due to length and stiffness resulting of the construction of the device more side effects than after intubation with a conventional single lumen tube is expected. possible side effects may be bleeding, swelling, sore throat or croakiness. the ez-blocker is a new device promising to overcome these side effects. the ez-blocker is a device placing a balloon into one bronchus to be able to provide single lung ventilation like the double lume tube. however, the ez-blocker is a catheter pushed through a conventional single lume tube after intubation with a hook on one and a balloon on the other distal end. the hook prevents the device from being pushed too far to be able to harm the lung. inside the ez-blocker is a small lumen able to deflate the lung which is blocked with the balloon. the device is easily positioned using a bronchoscope and when the anaesthesiologists confirmed the correct position of the device, the balloon can be inflated and deflated as needed. due to the easier approach the investigators expect less side effects as mentioned earlier using the ez-blocker compared to the double lume tube. as well the stress caused by intubation may be reduced.


Eligibility criteria:
inclusion criteria: * elective surgery * thoracic surgery with requiring single lung ventilation in lateral position * asa status 1-3 * oral and written consent to participation * age 18- 90 exclusion criteria: * contraindications against placing a double lume tube, like tracheal lesions, etc. * thoracic surgery within the last four weeks * any form of infection (pneumonia, pleural empyema) or suspected tbc * bmi higher than 45 * patients with a previous diagnoses or suspected difficult airway

Keywords: ez blocker double-lumen tube airway thoracic surgery time for intubation blind insertion conditions of surgery postoperative sore throat postoperative hoarseness
resistive exercise for arthritic cartilage health (reach)

Conditions: Osteoarthritis

Summary: female subjects over the age of 40 will be recruited and randomised into a progressive resistance training (prt) or sham-exercise group. the prt group will train at 80% of their peak strength, using keiser pneumatic resistance machines, and progress approximately 3% per session. strength will be re-assessed fortnightly. exercises will target muscles around the hip and knee. the sham-exercise group will train on the same equipment as the prt group except hip adduction, but without added resistance or progression. both groups will train 3 days per week for roughly 45 minutes for 6 months. it is hypothesised that high intensity prt will decelerate the tibial and femoral cartilage degeneration in the knee affected most by oa. primary outcome: articular cartilage morphology following 6 months high intensity progressive resistance training secondary outcomes: muscle and fat cross-sectional area (csa) (pre and post) muscle strength, power, endurance, and contraction velocity (pre, 3 months, \& post) medications (pre, 3 months, \& post) body composition (pre, 3 months, \& post) balance; physical function (pre, 3 months, \& post) questionnaires (pre, 3 months, \& post) * habitual exercise (pase) -womac index (pain, stiffness and functional ability) * depressive symptoms (depression scale) -quality of life (sf36) * confidence performing physical activity (ewart) -demographics


Eligibility criteria:
inclusion criteria: * female * aged over 40 years old * primary osteoarthritis in at least one knee using standard criteria of the american college of rheumatology (acr) criteria for classification of clinical osteoarthritis * ambulatory without human assistance * willingness to be randomised to experiential or control group * ability to attend scheduled exercise and testing sessions exclusion criteria: * regular exercise of any kind over the past 3 months (\>1dpw). * secondary osteoarthritis (traumatic or post-surgical), rheumatic disease, gouty or septic arthritis, paget's disease, pseudogout, major congenital abnormalities, hemochromatosis, wilson's disease and other rare forms of arthritis * joint injury, injection or surgery within the past 6 months or knee joint replacement * contraindications to mri/exercise

Keywords: osteoarthritis cartilage exercise progressive resistance training
effects of booster sessions on depression vulnerability following cognitive control training

Conditions: Major Depression in Remission

Summary: the current study aims to examine the impact of booster sessions of cognitive control training (cct) on indicators of depression vulnerability. remitted depressed individuals (rmd) will be randomized over two groups, each receiving 10 sessions of the adaptive paced auditory serial addition task, a well-established cct procedure (koster et al., 2017; siegle et al., 2007). during and following completion of the training procedure, functioning will be monitored on a weekly basis over a period of 15 weeks. during this period, one group will be offered booster sessions based on early warning signs for possible recurrence of depression, whilst the other group will not receive booster sessions.

cognitive impairments are closely associated with depression and recent studies have found that these cognitive problems can persist following remission of depression. internet-delivered cognitive control training (cct), and the adaptive paced auditory serial addition task (apasat) in particular, has shown to be an effective preventative intervention for remitted depressed individuals (rmd), where beneficial effects have been found for rumination, depressive symptomatology (hoorelbeke \& koster, 2017), and risk for recurrence of depression (hoorelbeke et al., 2021). at the same time, prior studies suggest significant heterogeneity in response to cct, where rmd individuals can show strong fluctuations in functioning in the months following completion of apasat training. in line with this, recent findings suggest that, for individuals with high-risk profiles, initial training gains may diminish over time, resulting in recurrence of internalizing symptomatology (hoorelbeke et al., 2022). as such, there may be merit in the use of cct booster sessions. currently, it is unclear whether offering additional cct sessions when rmd individuals are reporting increased symptomatology (i.e., adding booster sessions based on early warning signs for possible recurrence of depression) can increase the long-term effectiveness of cct. in this study, two groups of rmd individuals will perform 10 cct sessions, after which one group will be offered booster sessions (contingent on indicators of functioning). for this purpose, we will rely on 15 weekly mobile assessments, using the phq-9 questionnaire. in addition, functioning will be assessed using a more extensive assessment battery at baseline, post-training (2 weeks after baseline) and follow-up (15 weeks after baseline).

Eligibility criteria:
inclusion criteria: * history of ≥ 1 depressive episode(s) * currently in remission (≥ 3 months) * access to a computer with an internet connection * access to a smartphone exclusion criteria: * ongoing depressive episode * psychotic disorder (current and/or previous) * neurological impairments (current and/or previous) * excessive substance abuse (current and/or previous) * use of antidepressant medication is allowed if kept at a constant level

Keywords: depression remission relapse prevention cognitive control training internet intervention
evaluation of clinical characteristics and outcome of covid19 pneumonia in assiut university hospital

Conditions: Coronavirus

Summary: * evaluation of the clinical presentation of covid 19 pneumonia. * identification the risk factors of severing covid 19 pneumonia. * evaluation of the outcome of the disease.

coronavirus disease 2019 (covid-19) is defined as illness caused by a novel coronavirus now called severe acute respiratory syndrome coronavirus 2 (sars-cov-2; formerly called 2019-ncov), which was first identified amid an outbreak of respiratory illness cases in wuhan city, hubei province, china. it was initially reported to the who on december 31, 2019. on january 30, 2020, the who declared the covid-19 outbreak a global health emergency.on march 11, 2020, the who declared covid-19 a global pandemic, its first such designation since declaring h1n1 influenza a pandemic in 2009. the incubation period for coronavirus disease 2019 (covid-19) is believed to extend to 14 days, with a median time of 4-5 days from exposure to symptomatic onset. in one study, 97.5% of symptomatic patients developed symptoms within 11.5 days of becoming infected. most patients with coronavirus disease 2019 (covid-19) will experience the following (in descending frequency): fever, cough, fatigue, anorexia, shortness of breath, sputum production, myalgia. atypical presentations have been described, and older adults and persons with medical comorbidities may have delayed presentation of fever and respiratory symptoms. less common symptoms (\< 10%) include headache, confusion, rhinorrhea, sore throat, and hemoptysis. some patients have experienced gastrointestinal symptoms such as diarrhoea and nausea prior to developing fever and lower respiratory tract signs and symptoms. anosmia may precede the onset of respiratory symptoms. the most common serious manifestation of covid-19 upon the initial presentation is pneumonia. fever, cough, dyspnea, and abnormalities on chest imaging are common in these cases. bilateral distribution of ground-glass opacities (ggo) with or without consolidation in posterior and peripheral lungs was the cardinal hallmark of covid-19. however, with further analysis of increasing cases, a diversity of interesting ct imaging features were found, including crazy paving pattern, airway changes, halo sign, pleural changes including pleural thickening and pleural effusion, vascular enlargement, air bubble sign, lymphadenopathy, etc, which may shed light on the possible mechanism of lung injury in covid-19. on the laboratory aspect leukopenia, leukocytosis, and lymphopenia were common among early cases. lactate dehydrogenase and ferritin levels are commonly elevated.

Eligibility criteria:
inclusion criteria: * patients with covid 19 pcr positive exclusion criteria: * patients less than 18 years of age .
from inflammation to remodelling towards personalized diagnosis in post-acute sequelae of covid-19

Conditions: PASC Post Acute Sequelae of COVID 19; Long COVID; Long Covid-19; PASC; FAPI; FAP; Fibroblast Activation Protein Inhibitor; Fibroblast; Restrictive Lung Disease

Summary: rationale: the diagnosis and pathogenesis of long covid remains unknown. we have previously shown that \[68ga\]fapi positron emission tomography-computed tomography (pet/ct) imaging shows potential for diagnosis and molecular understanding of this syndrome. we have previously shown that fibroblast activation protein (fap) can be imaged in the lung, muscle and nasopharynx of long covid patients (with dyspnea and fatigue). however, these preliminary data are derived from a selective group of patients with long covid after critical covid-19. we aim to explore the generalizability of these findings in patients with long covid with dyspnea and fatigue, irrespective of the severity of their acute sars-cov-2 infection. primary objective: to assess if pulmonary fibroblast activity, measured by \[68ga\]fapi-46 pet/ct, is higher in patients with current long covid dyspnea and fatigue compared to patients with resolved complaints. study design: this is a zonmw funded single centre prospective observational cohort study of long covid-19 patients with dyspnea and fatigue. study population: we will recruit 60 adult long covid patients (aged \>20 years) of which 30 have complaints of dyspnea and fatigue and compare them to 30 patients with resolved complaints and healthy controls. main study parameters/endpoints: the primary endpoint is fap expression in the lung measured by \[68ga\]fapi-46 pet/ct. secondary endpoints are the expression of fap in other tissues (muscle) and the relation between fap and inflammation and remodelling biomarkers in various biological samples (e.g. serum/nasal epithelium). study procedures: in a single visit day the following data and samples will be collected: questionnaires, a lung function test, 6-minute walking test, blood samples, nose swabs, \[68ga\]fapi pet/ct scan and hrct scan. when increased \[68ga\]fapi uptake is measured in the muscles a muscle biopsy will be performed as well.


Eligibility criteria:
inclusion criteria: - self-reported complaints of dyspnea or fatigue \> 3 months after sars-cov-2 infection confirmed with pcr, serology test or covid-19 reporting and data system (co-rads) score 4/5. exclusion criteria: * inability or unwilling to give informed consent. * history of claustrophobia or feeling of inability to tolerate supine position for the pet/ct scans. * individuals who are pregnant or currently breastfeeding are not eligible to participate
octa in patients with primary open-angle glaucoma

Conditions: Open Angle Glaucoma

Summary: is to investigate retinal microvascular changes in primary open angle glaucoma patients using optical coherence tomography angiography.

optical coherence tomography angiography (oct-a) is a non-invasive imaging technique developed to visualize vascular networks in the retina and choroid. it utilizes low-coherence interferometry to measure changes in backscattered signal to differentiate areas of blood flow from areas of static tissue. octa provides both structural and functional (i.e. blood flow) information in tandem. the "corresponding" oct b-scans can be co-registered with the simultaneous oct angiograms so the operator is able to scroll through the oct angiogram like a cube scan. as a result, the precise location of pathology can be viewed on the corresponding oct b-scans. this makes octa a better tool when detecting the exact location of a retinal pathology. glaucoma is the first cause of irreversible blindness and represents approximately 15% of all causes of blindness . this makes it a real public health problem. in 2020, glaucoma affected about 80 million people worldwide, with nearly 75% of open-angle glaucoma primary open-angle glaucoma (poag) is a chronic, progressive, blinding, irreversible optic neuropathy characterized by damage to the optic nerve head and retinal nerve fibers with subsequent visual field defects ,elevated intraocular pressure (iop) is a crucial glaucoma risk factor that causes direct damage to rgcs and the optic nerve . moreover, glaucomatous retinsl ganglion cells loss occurs as well in people with normal iop, implying mechanisms behind pressure-mediated damage. rgcs death may be due to the reduced blood supply and microvasculature dysfunction may be essential in glaucoma pathogenesis . one hypothesis is that poag is categorized by impaired chemical endothelial signaling between both: a) the inner wall schlemm's canal endothelial cells as well as endothelial cells located in the ciliary body and the posterior longitudinal muscle that helps to set outflow resistance and b) the ocular vascular endothelial cell and underlying luminal smooth muscle for vessels supplying the retinal ganglion cells (rgcs). this hypothesis could explain why poag occurs across a spectrum of iop but it does not consider the role systemic endothelial cell dysfunction may play in the disease. the non-invasive technique of oct angiography (octa) can image and quantify both large vessels and the microvasculature of the optic nerve head (onh), retina and choroid layers . using the octa technique, reduced vessel density (vd) was observed in the onh, peripapillary area and macula, predominantly in primary open-angle glaucoma (poag)

Eligibility criteria:
inclusion criteria: - clinical diagnosis of primary open angle glaucoma. exclusion criteria: * media opacity * poor fixation due to advanced disease * associated vascular retinopathy * chronic uveitis * optic nerve disease due to other etiologies