Kornimate/medical-research-clean huggingface dataset:
prevention of intraoperative nausea and vomiting during cesarean section

Conditions: Cesarean Delivery

Summary: the study investigates the incidence of intraoperative nausea and vomiting under spinal anesthesia using a phenylephrine infusion with and without prophylactic antiemetics.


Eligibility criteria:
inclusion criteria: * english speaking asa i-ii non-laboring women with single gestations ≥36 weeks * scheduled or unscheduled cesarean delivery under spinal anesthesia * height: 5 feet-5 feet 11 in. exclusion criteria: * laboring women needing an emergency cesarean delivery * subjects less than 18 years of age * receipt of a drug with antiemetic properties in the 24 hours prior to cesarean section * allergy to ondansetron, or metoclopramide * severe hypertensive disease of pregnancy defined as systolic blood pressure (sbp)\>160mmhg, diastolic blood pressure (dbp)\>110mmhg requiring antihypertensive treatment or associated with significant proteinuria. * severe cardiac disease in pregnancy with marked functional limitations * diabetes type i * patients on monoamine oxidase inhibitors or tricyclic antidepressants * morbid obesity (body mass index (bmi)\>45) * inclusion in another anesthetic study involving drug administration

Keywords: nausea vomiting
cost of parkinson's disease in hong kong

Conditions: Parkinson Disease

Summary: the goal of this study is to estimate the cost of disease and falls among people with parkinson's disease in hong kong . there will be no intervention delivered to the participants. the healthcare cost of 12 months will be recorded using self-report and and the hospital authority clinical management system.

objective: estimate the cost of disease and falls among people with parkinson's disease in hong kong. design: prospective cost-of-illness analysis with one baseline assessment and two follow-up assessments after 6 and 12 months. participants: community-dwelling participants with parkinson's disease. intervention: n/a. outcome measures: self-reported questionnaires and the hospital authority clinical management system will be used to inform the healthcare utilisation. we will also assess the number of falls, severity of parkinson's disease, level of disability, balance, risk of falls, and quality of life. predictors of cost include fall frequency, balance status, disease severity, level of disability, quality of life and disease duration. analysis: cost-of-illness analysis will estimate the direct and indirect cost, using a prevalence-based approach, by converting physical units to monetary value based on unsubsidised charges for healthcare in hong kong published by the hospital authority for the year 2022. a multiple regression analysis will determine predictors influencing the overall cost. a two-way anova will assess differences in healthcare costs among frequent, infrequent and non-fallers. sensitivity analysis will include (1) tornado plots for studying the degree of impact of the cost variables on mean cost, (2) analysis after removing cost outliers and (3) varying the expenses on selected cost items by 25%.

Eligibility criteria:
inclusion criteria: community-dwelling participants with a confirmed diagnosis of parkinson's disease reside in hong kong exclusion criteria: patients who are bedridden or solely wheelchair users, have atypical parkinson's syndrome and have other associated major illnesses, such as stroke.

Keywords: cost of illness falls pd disease burden
promoting physical activity in chronic obstructive pulmonary disease (copd) through new technology and health coaching

Conditions: Chronic Obstructive Pulmonary Disease; Physical Activity

Summary: the objective of this project is to validate the proposed smartphone-based activity monitor and to test its use for motivational interviewing based counseling for physical activity in chronic obstructive pulmonary disease (copd).


Eligibility criteria:
inclusion criteria: * men and women age 40 years and older * current or former smoker of at least 10 pack-years * diagnosis of gold stage ii to iv copd as documented by pulmonary function testing (fev1 (forced expiratory volume in 1 second) \<80 percent predicted, fev1/fvc(forced vital capacity)\<0.71) * able to walk independently or with a walking aid (e.g. wheeled walker, cane, standard walker) exclusion criteria: * unable to walk without assistance of another person * patients with a high likelihood of being lost to follow-up or contact (patients with active chemical dependency), are planning to move out of the state, are not living in the healthcare area. * patients with an inability to provide good data or follow commands (patients who are disoriented, have a severe neurologic or psychiatric condition).

Keywords: chronic obstructive pulmonary disease physical activity self management exercise technology motivational interviewing
reliabılıty,validity of the turkish version of the back pain function scale

Conditions: Low Back Pain

Summary: this study, we performed the turkish version validity and reliability of the back pain function scale.

low back pain is defined as the pain that can occur in the region between the lower border of the scapula and the hip, sometimes spreading to the lower extremities, which causes activity limitation and is one of the most common health problems in the society. appropriate use of assessment questionnaires is one of the most important steps in the evaluation of the functional level of the patient and in deciding on an effective treatment protocol. the purpose of our study is to determine the turkish version, validity and reliability of back pain function scale. 180 patients with chronic low back pain were included in the study. test-retest and internal consistency analysis were conducted to determine the reliability of the questionnaire. test-retest results were evaluated using the intraclass correlation coefficient method. intraclass correlation coefficient results vary between 0.857 and 0.951, and the total intraclass correlation coefficient value is found to be 0.961. these results indicate that the test-retest responses have a high degree of correlation. for internal consistency analysis, the cronbach alpha score was fou nd to be 0.910, indicating that the survey has high internal consistency. the total score obtained from the back pain function scale was assessed using the pearson correlation analysis with the total scores obtained from the roland morris disability scale , oswestry disability scale. pearson's correlation coefficient was -0.840 with oswestry disability scale of back pain function scale, pearson's correlation coefficient was -0.803 with roland morris disability scale. the results show that the back pain function scale correlates perfectly with the oswestry disability scale and the roland morris disability scale. in conclusion, turkish version of bac pain function scale is valid and reliable.

Eligibility criteria:
inclusion criteria: having a low back pain literate exclusion criteria: pregnant canser trauma

Keywords: validity, reliability, low back pain
effect of oc000459 on eosinophilic airway inflammation in severe asthma

Conditions: Severe Eosinophilic Asthma

Summary: the aim is to study the effect of oc000459 on eosinophilic airway inflammation and asthma control in subjects with severe, refractory eosinophilic asthma.

at week 12 subjects not on oral corticosteroids (ocs) will complete the treatment period and return after 4 weeks for final follow up visit. those subjects who were taking ocs at baseline will continue for a maximum of 12 additional weeks, double blind period during which their current ocs treatment will be titrated down according to their clinical response.

Eligibility criteria:
inclusion criteria: * show evidence of reversible airflow obstruction documented within the previous 12 months or prior to randomisation. * meet the european respiratory society/american thoracic society (ers/ats) criteria for severe asthma at screening. * have documented evidence of eosinophilic airway inflammation during the 12 months prior to screening. * have evidence of eosinophilic airway inflammation at screening as reflected by an induced sputum eosinophil count of ≥3%. * subjects who are taking oral corticosteroids (ocs) must be receiving a 20 mg prednisolone equivalent dose, or less, daily for at least four weeks before the first dose of study drug. the dose of ocs should be unchanged for at least 14 days prior to the baseline visit. exclusion criteria: * treatment with xolairtm or anti-th2 biologicals within 6 months prior to screening. * subjects with clinically significant abnormal serum biochemistry, haematology and urine examination values * subjects who have been hospitalised in the last 3 months. * history of more than 2 episodes of confirmed bacterial lower respiratory tract infection or current lower respiratory tract infection. * subjects are current smokers or have a smoking history of \>15 pack years. * significant comorbidity that in the investigator's opinion is likely to impact the subject's participation in a 26 week study. * presence of a clinically important lung condition other than asthma, malignancy or previous history of cancer in remission for less than 12 months, clinically important liver or kidney disease, uncontrolled clinically significant cardiovascular disease, hypereosinophilic syndromes such as churg-strauss syndrome or eosinophilic oesophagitis.
clinical characteristics and surgical outcomes of full-thickness macular hole without focal vitreomacular traction.

Conditions: Macular Holes

Summary: this multicenter, retrospective, observational comparative study. we occasionally encounter ftmhs in which pvd has not been achieved and vmt is absent. these ftmhs cannot be defined by stage in the gass1) or ivts3) classification. it is not known whether traction is involved in the development of these atypical macular holes, but they are often classified as gass stage 2 or 3 according to the size of the hole. the aim of this study was to investigate the clinical features and surgical outcomes of ftmhs without focal vmt and to discuss possible underlying mechanisms.

the clinical characteristics and surgical outcomes the patients diagnosed with ftmh without focal vmt in the macula (classified as vmt-) are presented, in addition to a comparative analysis of the patients presenting with classic stage 2 ftmh with focal vmt (classified as vmt+) according to international classification criteria.

Eligibility criteria:
inclusion criteria: - macular hole without posterior vitreous detachment at the fovea exclusion criteria: * macular hole with posterior vitreous detachment at the fovea * stage1.3.4 macular hole * macular hole-associated retinal detachment * macular hole with subretinal hemorrhage * traumatic mh

Keywords: macular hole epiretinal prolidferation vitrectomy
safety and acceptance of gourmed© prepackaged nutritional products in the elderly dysphagic patient: modiet project

Conditions: Dysphagia

Summary: the aim of the modiet study is to evaluate the usefulness of the gourmed© prepackaged diet in guaranteeing a safe, compliant and effective diet satisfying the nutritional needs of the elderly dysphagic patient.

the objective of the modiet study is to evaluate the usefulness of the gourmed© (medicair food srl, milano, italy) prepackaged diet in guaranteeing a safe, compliant and effective diet satisfying the nutritional needs of the elderly dysphagic patient.

Eligibility criteria:
inclusion criteria: * age 65 years and over * gugging swallowing screen ranging 10-20; exclusion criteria: * known or suspected intolerance to any ingredient * taking other prepackaged products for dysphagia * creatinine ≥1,5 mg/dl

Keywords: dysphagia diet elderly subjects
safety and efficacy of remote ischemic conditioning for spontaneous intracerebral hemorrhage

Conditions: Intracranial Hemorrhages

Summary: the purpose of this study is to determine the efficacy and safety of remote ischemic conditioning in treating acute intracerebral hemorrhage.

spontaneous intracerebral hemorrhage is a major cause of disability and mortality among different types of stroke, and few effective treatment options are available. therefore, it is essential to develop new approaches to improve the prognosis of these patients. recently, remote ischemic conditioning (ric), a method that involves inducing multiple brief episodes of ischemia and reperfusion in the limbs, has been indicated to exert neuroprotective effects in experimental stroke. the underlying neuroprotective mechanism triggered by ric induces gene expression, alters pathways, promotes neurogenesis and blood vessel development, reduces oxidative stress and neuronal apoptosis, and inhibits proinflammatory signals. previously, several clinical trials have shown that single or repeated ric treatments for cerebrovascular diseases are feasible and safe. therefore, we hypothesize that ric could improve functional outcome in patients with intracerebral hemorrhage. we design this prospective, multicenter, randomized controlled trial to evaluate the efficacy and safety of ric in treating intracerebral hemorrhage.

Eligibility criteria:
inclusion criteria: 1. age ≥18 years. 2. supratentorial intracerebral hemorrhage confirmed by brain ct scan. 3. no disability in the community before ich (premorbid mrs≤ 1). 4. nihss score ≥ 6 and gcs ≥ 8 upon presentation. 5. able to commence ric treatment within 24 hours of stroke onset. 6. systolic blood pressure ≤ 180 mmhg before randomization. 7. signed and dated informed consent is obtained. exclusion criteria: 1. definite evidence of secondary ich, such as structural abnormality, brain aneurysm, brain tumor, thrombolytic drug. 2. hematoma with a mid-line shift, cerebral herniation or isolate intraventricular hemorrhage. 3. already booked for surgical treatment. 4. life expectancy of less than 180 days due to comorbid conditions. 5. concurrent use of anticoagulation drugs including warfarin, dabigatran, rivaroxaban or coagulopathy (defined as inr, aptt, and pt beyond the upper limit of normal range). 6. any soft tissue, orthopedic, or vascular injury, wounds or fractures in healthy upper limb which may pose a contraindication for application of ric. 7. severe hepatic and renal dysfunction, or alt/ast \>3 times upper limit of normal, or serum creatinine \>265umol/l. 8. known pregnancy or breastfeeding. 9. patients being enrolled or having been enrolled in other clinical trial within 3 months prior to this clinical trial. 10. a high likelihood that the patient will not adhere to the study treatment and follow up regimen. 11. patients unsuitable for enrollment in the clinical trial according to investigators decision making.

Keywords: intracranial hemorrhage remote ischemic conditioning
the role of angiojet rheolytic thrombectomy in the management of iliofemoral deep venous thrombosis

Conditions: Iliofemoral Deep Vein Thrombosis

Summary: the aim of this study is to evaluate the efficacy and safety of rheolytic thrombectomy in restoring venous patency dvt, periprocedural complications and development of pts after tratment of iliofemoral dvt.

deep venous thrombosis (dvt) is a common disease affecting approximately 0.1% of the world population.1 the incidence of dvt steadily increases as the patient gets older. one-third of patients with dvt may develop pulmonary embolism (pe)2. dvt can significantly influence the quality of life of patients, and it represents an important clinical and economic disease burden on health-care systems. over the years, different options for dvt treatment have been introduced to restore patency, save valve function, and reduce the occurrence of post-thrombotic syndrome (pts). the conventional treatment of acute dvt aims to prevent thrombus propagation and to reduce the risks of pe and dvt recurrence5. however, this treatment is ineffective at reducing thrombus burden and consequently does not prevent pts. recent advances in catheter-based interventions have led to the development of a variety of minimally invasive endovascular strategies to remove venous thrombus. lower-extremity dvt, especially proximal or iliofemoral dvt, has been demonstrated to confer the greatest risk for complications such as pulmonary embolism, thrombosis recurrence, and post- thrombotic syndrome. most practice guidelines recommend early clot removal for patients with iliofemoral dvt who have symptoms less than 14 days in duration, good functional ability, and acceptable life expectancy and who are at low risk for bleeding complications. removal of clot can be achieved by using catheter-directed thrombolysis (cdt) or pharmacomechanical.use of cdt is limited because of the lengthy procedure/hospitalization time and intensive care unit (icu) stays required for the procedure11. pharmacomechanical was developed to address the limitations of cdt by combining catheter-based and mechanical technology to fragment and/or aspirate thrombus in addition to delivering a thrombolytic drug throughout the thrombus. percutaneous rheolytic thrombectomy (rt) technique is highly effective at clearing thrombus, which preserves venous valve function and prevents subsequent pts. the use of rt to treat dvt may reduce long-term morbidity in dvt patients by restoring the patency of the veins and preventing pulmonary embolism.

Eligibility criteria:
inclusion criteria: acute if dvt life expectancy more than 1 year exclusion criteria: * recurrence of dvt chronic dvt the catheter cannot be used in vessels smaller than 6mm. patients have contraindications for endovascular procedures patients cannot tolerate contrast media in patients with lesions that cannot be accessed with the guide wire pregnancy history of pelvic surgery with left iliac vein injury or pelvic radioactive therapy
coronary artery plaque burden and morphology in type 2 diabetes mellitus.

Conditions: Type2 Diabetes; Atherosclerosis; Plaque, Atherosclerotic; Plaque Vulnerability; Diabetes Complications; Microalbuminuria; Coronary Computed Tomography Angiography

Summary: unstable plaque, the primary cause of myocardial infarction, is characterized by distinct a morphology including positive remodeling (pr), low attenuated plaque (lap), napkin ring sign (nrs), and spotty calcifications (sc) the purpose of the present study is to investigate the influence of microvascular dysfunction and additional risk factors on plaque morphology and plaque burden in patients with diabetes mellitus.

coronary artery disease (cad) is the leading cause of death and morbidity in type 2 diabetes mellitus (t2dm) and diabetics holds the same risk for death or myocardial infarction (mi) as patients with a prior (mi) without diabetes. in addition to macrovascular complications, and traditional cardiac risk factors, t2dm is burdened by microvascular dysfunction affecting several organs. the dynamics between microvascular dysfunction, known cardiac risk factors and coronary atherosclerosis in diabetic disease is not well characterized. in the present study, a primary cohort of 300 type 2 diabetics and a subgroup of 50-100 type 1 diabetics will be examined with ccta at baseline and after one year. in addition, cad in diabetes will be compared to a historical cohort of patients with acute myocardial infarction (ami). all study participant will undergo the following examinations at baseline: * ccta * cac-score * transthoracic echocardiography * 12-lead ecg * blood pressure and pulse frequency * height, weight, waist to hip-ratio * blood samples and urin samples * medical history after 12 months all of the above examinations will be repeated.

Eligibility criteria:
inclusion criteria: * age \> 18 years * type 1 or 2 diabetes mellitus * ability to provide informed conscent exclusion criteria: * history of cad * symtoms of cad (angina) * any tachyarrhythmias making ccta impossible * glumerular filtration rate (gfr)\< 45 ml/min * allergy to iodine contrast * critical illness with life expectancy less than 1 year * documented heart failure
behavior problems prevention using the online triple p parenting program

Conditions: Parenting

Summary: the triple p program is a comprehensive system of parenting and family support of multilevel preventive intervention, developed for families with members up to 16 years of age, whose objective is to improve parenting skills and prevent or modify dysfunctional parenting practices, thus reducing family risk factors that affect both child abuse, behavioral problems and emotional problems.

based on the importance that evidence-based parental interventions have acquired and the need from the health field to provide innovative alternatives that facilitate access to this type of services, parental support programs given through the web emerge. there is evidence that supports the idea that parenting programs taught through the web have an influence on reducing disruptive behaviors in children. triple p online (tpol) is an adaptation of the positive parenting program, triple p, a program that has been empirically tested. this adaptation is a parental intervention through the web with self-directed modality, which is based on level 4 of the triple p parental program and is configured in 8 interactive sessions with online modules. the topics covered are: 1) what is positive parenting, 2) reinforcing the behavior we want, 3) teaching new skills, 4) managing negative behaviors, 5) managing disobedience, 6) preventing problems through planning, 7) making fun outings, 8) raising confident and competent children. the main results observed in the implementation of the online triple p program are (sanders et al, 2012): reduction of problem child behavior, dysfunctional parenting styles, increasing parents' confidence in their parenting role, and reduction of parental anger.

Eligibility criteria:
inclusion criteria: * belong to one of the three socio-economic levels according to simce classification (high, medium and low). * attend to a primary school of the municipality of lo barnechea, santiago, chile. * previous participation in the instruments validations stages. * identification in the strengths and difficulties questionnaire (sdq) with behavior problems above the 80th percentile. * have internet access. exclusion criteria: * attend to a school that is developing or implementing a manualized program for parents associated with the prevention of behavioral problems * participating in a similar study.

Keywords: program parental competence behavior problems emotional problems