Kornimate/medical-research-clean huggingface dataset:
treatment of binge eating in obese patients in primary care

Conditions: Obesity; Binge Eating

Summary: this study will test the effectiveness of two empirically-supported but distinct treatments for recurrent binge eating in obese patients: 1) cognitive behavior therapy, using a pure self-help approach and 2) sibutramine, an anti-obesity medication also found to have efficacy for binge eating. self-help cognitive behavior therapy and sibutramine will be administered alone and in combination in a primary care setting.


Eligibility criteria:
inclusion criteria: * obese (bmi \>= 30) exclusion criteria: * medication regimen that represents medical contraindication to sibutramine * serious unstable or uncontrolled medical conditions that represent contraindication to sibutramine * pregnancy

Keywords: obesity binge eating sibutramine self-help primary care
evaluation of physical fitness after stroke

Conditions: Stroke

Summary: this study aims to examine the evolution and determinants of physical fitness after stroke.

stroke is a major cause of chronic severe disability. more than 50% of stroke survivors have residual motor and functional deficits which have an impact on their participation and quality of live (patel et al, 2006). limitations on daily functioning may lead to physical inactivity and a sedentary lifestyle. sustained physical inactivity (deconditioning) induces a reduction in aerobic capacity, which may further increase the risk of cardiovascular diseases in these individuals above that associated with stroke itself. therefore, improving aerobic capacity may be essential in prevention of secondary diseases due to lack of fitness in the stroke population. previous studies have also indicated that a critical level of aerobic capacity must be met in order to function independently (cress et al, 2003). therefore, in addition to disease prevention, enhancing aerobic capacity in individuals with stroke may also have beneficial effects on promoting functional abilities and independent living. it is also known that a limitation in functional performance is mostly associated with a restriction in social activities (icidh-2-model). clearly, stroke survivors can benefit from counseling on participation in physical activity and exercise training. a recent meta-analysis (pang et al, 2006) showed that there is good evidence to support the use of aerobic exercise to improve aerobic capacity in individuals with stroke. however, before going on that road, one needs to know more about the level of physical activity and physical fitness in the stroke population.

Eligibility criteria:
inclusion criteria: 1. first-ever stroke as defined by who 2. aged \< 75 years, 3. able to comprehend simple oral instructions. exclusion criteria: 1. other neurological impairments with permanent damage 2. stroke-like symptoms due to subdural haematoma, tumour, encephalitis or trauma 3. pre-stroke barthel index \<50 4. unable to perform a maximal exercise test in accordance with absolute contra-indications for exercise testing (acc/aha) 5. no informed consent.

Keywords: stroke physical fitness evolution determinants
the impact of the inflammation index on predicting postoperative complications in ovarian cancer

Conditions: Complications; Ovarian Cancer

Summary: advanced-stage ovarian cancer surgery is a procedure that inherently carries a high risk of mortality and morbidity. however, there are some uncertainties regarding whether these complications can be predicted before the operation. in this study, we aimed to examine the relationship between complications and inflammation.

objective: cytoreductive surgery (crs) is the most important treatment method that increases survival in advanced-stage ovarian cancer patients. however, complications after crs are seen as a significant cause of morbidity and mortality. preoperative risk assessment of patients is of great importance. in recent years, inflammatory markers have been the subject of many studies evaluating malignancy and surgical outcomes. neutrophil-lymphocyte ratio (nlr), platelet-lymphocyte ratio (plr), systemic inflammation index (sii), and systemic inflammatory response index (siri) stand out as prognostic and predictive tools in malignancies. this study aims to evaluate the preoperative inflammatory markers in patients who underwent crs for advanced-stage epithelial ovarian cancer and to investigate the predictive power of postoperative complications. materials and methods: this retrospective study examines patients who underwent crs due to advanced-stage epithelial oc at sakarya university training and research hospital between 2014 and 2023. postoperative complications of the patients were graded according to the clavien-dindo classification; nlr, plr, sii, and siri values were calculated using preoperative laboratory data, and the predictive values of inflammatory markers were analyzed with roc curves.

Eligibility criteria:
inclusion criteria: * the inclusion criteria of the patients were determined as those who underwent surgery with the diagnosis of figo stage iiic and iv epithelial ovarian cancer. exclusion criteria: * the exclusion criteria of the study were patients who had recently undergone blood transfusion or bacterial or viral infection within two weeks before surgery. * pregnant patients or patients with hematological diseases. * patients with thrombotic diseases. * patients with immunological diseases. * patients with severe liver or kidney diseases, patients with a previous history of cancer. * patients receiving anticoagulant and/or antiplatelet therapy due to venous or arterial thromboembolism.

Keywords: inflammation markers complications ovarian cancer
quantitative flow ratio or angiography for the assessment of non-culprit lesions

Conditions: Coronary Artery Disease

Summary: the aim of this study is to study whether the use of complex 3-dimensional assessment of the severity of a stenosis improves angina and in general cardiovascular outcomes in patients who have residual intermediate coronary artery stenosis following an acute coronary syndrome (acs) treated with percutaneous coronary intervention (pci). goals of the study are: * to investigate whether decision-making based on quantitative flow reserve (qfr) is associated with a decrease in angina 3 months after an acs * to investigate whether use of qfr is associated with an improved prognosis.

the study is a single-center, randomized superiority trial to compare two strategies for the assessment of the hemodynamic relevance of coronary lesions. the primary analysis will be on the per-protocol principle (i.e. including all patients who are not protocol violators). a separate analysis will be performed on an intention-to-treat basis (i.e. all randomized patients randomized to a treatment arm). primary endpoint 1. angina questionnaire secondary endpoints: number and % of patients undergoing pci seattle angina questionnaire * saq physical limitation scale * saq angina stability scale * saq angina frequency scale * saq quality of life * saq treatment satisfaction disease perception scale follow-up (3 and 12 months) - patient-oriented composite endpoint (death, myocardial infarction, unplanned revascularization) and its components.

Eligibility criteria:
inclusion criteria: * successfully treated acute coronary syndrome * at least one additional intermediate stenosis (\>30% and \<90%). * patient ≥18 years old exclusion criteria: * stenoses or patients a priori not amenable to treatment with pci (at the discretion of two interventional cardiologists - e.g. patients with limited life expectancy, stenosis in very small vessels, very diffuse disease with complex/very calcified stenosis requiring surgery etc). * persistent symptoms or evidence of ischemia requiring intervention of the non-culprit lesion. * any contraindication to pci according to guidelines * an acs in the period following the index acs and randomization * timi (thrombolysis in myocardial infarction) flow grade \< 3 in the culprit vessel * presence of thrombus in the non-culprit lesion * participation in another randomized interventional study interfering with the present protocol * patient unable to give informed consent * women of child-bearing potential or lactating * previous coronary artery bypass surgery cabg * recent (within 30 days) unsuccessful pci * decompensated congestive heart failure (chf) or hospitalization due to chf during the last 3 months * left ventricular ejection fraction \<30% * severe chronic obstructive pulmonary disease (copd) * severe valvular heart disease * ffr (or rfr, ifr etc) assessment of non-culprit lesions at the time of the index procedure
interferon pathway activation in monogenic and nonmonogenic forms of pediatric sle

Conditions: Systemic Lupus Erythematosus of Childhood

Summary: pediatric sle includes monogenic forms, some of which involve the interferon type i (ifn-i) pathway. the ifn-i pathway is renally active in adult sle and correlates with the extent of renal damage. in pediatric sle, and particularly in lupus nephritis, activation of the ifn-i pathway has never been studied, nor is it known whether monogenic forms underlie more pronounced interferon activation.

pediatric systemic lupus erythematosus (sle) (csle), compared with adult sle, is characterized by a more severe phenotype, with more marked hematologic, neuropsychiatric, and renal changes. lupus nephritis is a pivotal manifestation of pediatric sle and an important prognostic factor. it is hypothesized that activation of the interferon pathway is more pronounced in monogenic forms, in which the response to ifn-i represents the primary alteration and likely the main pathogenic mechanism. this finding may also be relevant in light of the availability of new drugs that selectively target the ifn-i pathway. demonstration of ifn-i pathway activation could be used as a diagnostic algorithm in aggressive pediatric forms resistant to immunosuppressive therapy and represent a therapeutic target.

Eligibility criteria:
inclusion criteria: * diagnosis of sle arising before the age of majority (until the age of 18 years) according to slicc and/or eular criteria 2019; * clinical, laboratory and/or histologic evidence of renal involvement manifested before the age of 18 years; * signature of informed consent. exclusion criteria: * onset of renal disease after the age of 18 years; * sle secondary to drugs or associated with other diseases such as systemic sclerosis, rheumatoid arthritis, sjögren's syndrome, and other connectivities.
symptom-targeted rehabilitation for concussion

Conditions: Mild Traumatic Brain Injury

Summary: the investigators are comparing two methods for helping improve everyday cognitive functioning in canadian armed forces (caf) veterans who have sustained a mild traumatic brain injury (mtbi). the two methods are 1) providing educational materials (education group) and 2) individual cognitive rehabilitation delivered by a trained occupational therapist or speech-language pathologist (therapy group). the study is a pilot randomized controlled clinical trial (rct), and will serve as pilot data for a future rct.

the investigators are comparing two different methods for helping canadian armed forces veterans with mild traumatic brain injury (mtbi) manage everyday cognitive difficulties. cognitive rehabilitation is a type of therapy that helps people with brain injury who have challenges in everyday thinking. the investigators have developed a streamlined version of this type of cognitive rehabilitation therapy that can be done in person or virtually and takes place over a 3-week period. the investigators will provide education materials only to one group and individual cognitive rehabilitation delivered by a trained speech language pathologist or occupational therapist to the other group. the investigators want to find out whether the individual therapy is better than providing the usual educational material. the therapy sessions are audio-recorded. at mcmaster, the investigators job is to listen to the recordings and making sure the therapists are following the study manual. that includes making notes of what the therapists say or do. what the investigators learn in this study may help veterans with mtbi and cognitive issues affect their abilities to do everyday activities.

Eligibility criteria:
inclusion criteria: * is a community-dwelling canadian armed forces veteran. * is age 18 years or older. * self-identifies as a fluent english speaker. * has no previous history of neurological disorder affecting cognition, by self-report. * is able to participate in rehabilitation for 4 weeks: 3 weeks of treatment + baseline + outcome assessment, with potential rescheduling for missed sessions. * is not actively participating in cognitive rehabilitation directed by a registered health professional (e.g., speech-language pathologist or occupational therapist). * has access to an electronic device with zoom video platform capacity and internet access. exclusion criteria: * a score of less than 20 on the montreal cognitive assessment (moca), which indicates a risk for dementia. * cannot identify at least 3 problems on the common cognitive complaints after concussion questionnaire (c4), as there would be insufficient areas for intervention.

Keywords: cognitive rehabilitation cognitive functioning
mobile health application (pact) to improve engagement in advance care planning

Conditions: Malignant Solid Neoplasm

Summary: this clinical trial tests a new mobile health application (app) called planning advance care together (pact) to help people with cancer talk about and plan for advance care planning (the care they would want if they were unable to communicate) with their loved ones and doctors. the development of the pact mobile app may help future patients incorporate their social network (typically, but not exclusively, family) into the advance care planning process.

outline: patients and support persons are randomized to 1 of 2 arms. arm i: participants use pact mhealth app. arm ii: participants engage in standard care with no modifications. after completion of study intervention, participants are followed up at 3 and 6 months.

Eligibility criteria:
inclusion criteria: * patient: diagnosis of poor prognosis advanced cancer defined as locally advanced or metastatic cancer and/or disease progression following at least first line systemic therapy. * patient: access to a mobile device; the principal investigator (pi) will ensure that those who have access to a mobile device have access to a mobile device with internet access to ensure they can complete study procedures. * patient: the ability to provide informed consent. * patient: identification and enrollment of a loved support person. * patient: 18 years of age or older. * support person: the person (family member or friend) whom the patient indicates being a support person. * support person: english speaking. * support person: 18 years of age or older and able to provide informed consent. * provider: current clinical practice and/or research with advanced cancer patients. * provider: a history of 3+ years working with advanced cancer patients. * provider: 18 years of age or older. providers across disciplines (e.g., social work, oncology) will be enrolled. exclusion criteria: * patient: not fluent in english. * patient: severely cognitively impaired (as measured by short portable mental status questionnaire scores of \>= 6) to be delivered by trained study research staff during screening. * patient: too ill or weak to complete the interviews (as judged by the interviewer). * patient: currently receiving hospice at the time of enrollment. * patient: children and young adults under age 18. * patient: resides outside of the united states. * support person and providers: resides outside of the united states.

Keywords: advance care planning advance directives end-of-life cancer
observational study on dynamic changes of blood pressure during post-epileptic seizure stage (ocbps)

Conditions: Epilepsy; Seizure; Blood Pressure

Summary: this article details a multicenter study on changes of blood pressure and heart rate during post-epileptic seizure stage.

in contrast to the well-documented changes in heart rate and respiration, post-seizure changes in blood pressure have received insufficient attention. fluctuations in blood pressure may worsen brain injury and elevate the risk of sudden unexpected death in epilepsy (sudep), yet evidence regarding postictal blood pressure changes remains limited. this multicenter study aims to investigate the changes of blood pressure and heart rate during post-epileptic seizure stage in epilepsy patients, providing high-quality evidence on postictal hemodynamic changes and laying the foundation for future interventions. the study will enroll 2000 seizure events from hospitalized epilepsy patients aged 14-80 years between october 2024 and october 2025. data on blood pressure, heart rate and blood oxygen will be collected during multiple time intervals post-seizure, alongside clinical information such as seizure type, duration, and medication use.

Eligibility criteria:
inclusion criteria: 1. age 14-80 years old, male and female; 2. meet the diagnostic criteria for epilepsy, including focal epilepsy and generalized epilepsy. 3. patients diagnosed with epilepsy, with at least one seizure during the hospitalization. 4. seizures lasting longer than 30 seconds (including convulsive and non-convulsive status epilepticus, if seizure cessation can be determined and medications were recorded, they can be included). 5. hypertensive patients who are on antihypertensive medication and have well-controlled blood pressure are eligible. 6. patients who agree to participate in the study. exclusion criteria: 1. patients with structural heart disease, coronary artery disease (cad), cardiomyopathy 2. patients with severe systemic diseases 3. pregnancy 4. preictal seizures or myoclonic seizures.

Keywords: seizures epilepsy blood pressure change post-seizure post-epileptic seizure stage
blue light therapy of c. acnes

Conditions: Acne

Summary: this proposal aims to investigate a novel light-based treatment to reduce morbidity in shoulder surgical patients. this has potential to improve outcomes and reduce health care utilization associated with infectious complications of shoulder arthroplasty. participants will be healthy male volunteers at least 18 years of age. they will be on study for approximately 2 days.

participants will have two study visits (consent plus treatment and swabs for culture). these visits will be conducted at the main uw hospital, uw health at the american center, or uw health at 1 s. park. all visits will be conducted in reserved conference rooms at each location. once a subject is determined to be eligible and has consented to the study, they will be randomized into one of three treatment groups. study team has blank envelopes that contain one of the three treatment groups enclosed. after a subject consents to the study, the study team will randomly draw an envelope to assign a treatment arm. arm 1. one group will receive 5% topical benzoyl peroxide gel plus 2% chlorhexidine gluconate with 70% isopropyl alcohol arm 2. one group will receive blue light therapy plus 2% chlorhexidine gluconate with 70% isopropyl alcohol arm 3. one group will receive both of the above treatments all participants will have their contralateral shoulder serve as the control (2% chlorhexidine gluconate with 70% isopropyl alcohol only). all treatment will be provided by the study team. participants will also be asked to complete a research intake form. if c. acnes does grow for a tissue culture, investigators plan to bank a colony of the bacterium for potential use in a future study. there will be no added risk to research subjects as no additional cultures will be taken and samples will be completely anonymized. the banked samples will simply be a colony of growth from the culture media for storage for possible future use. samples will be banked for 5 years from the date of study completion after which time the samples will be destroyed.

Eligibility criteria:
inclusion criteria: * healthy male * 18 years or older exclusion criteria: * allergy to benzoyl peroxide or chlorhexidine * \<18 years of age * previous history of shoulder infections * antibiotics taken within one month of research visit * immunocompromised state * active cancer * diabetic * skin lesions or abrasions over the deltopectoral interval * topical corticosteroid treatment to either shoulder or or systemic corticosteroid treatment within 2 weeks of research visit * topical benzoyl peroxide treatment to either shoulder within 2 weeks of research visit * blue light therapy treatment to either shoulder within 2 weeks of research visit * prior incision over the deltopectoral interval of either shoulder * contraindication to blue light treatment
prevention of orthostatic hypotension with electric stimulation in persons with acute sci

Conditions: Spinal Cord Injury; Orthostatic Hypotension

Summary: background: the presence of orthostatic hypotension (oh) as a consequence of blood volume redistribution during verticalisation in persons with spinal cord injury (sci) is a common condition. aims: to investigate the impact of three different types of electric stimulation (es) (es of the abdominal muscles versus es of lower limb muscles versus simultaneously es of abdominal and lower limb muscles versus control) on blood pressure stabilization and verticalisation-degrees between 0° and 70°. the hypothesis is, that the es-induced contractions of the muscles cause a stabilisation respectively an increase of the blood pressure during the tilt-table test. subjects: 20 women and men, at least 18 years of age, following an acute and traumatic sci, with a lesion level above t6, an american spinal injury association (ais) impairment scale a,b or c and a diagnosis of oh (by tilt table test) were eligible for the study. methods: each patient underwent randomly three different types of es sessions while being positioned on a tilt-table. the following sessions were planned: a) es of the abdominal muscles b) es of the lower limb muscles c) combination of a and b d) control session (=diagnostic session) study type: intervention design: prospective interventional study


Eligibility criteria:
inclusion criteria: * inpatients * positive diagnosis of oh * acute traumatic sci * lesion level above t6 * ais a, b or c exclusion criteria: * fractures of the lower limbs * decubitus (npuap \>2) * massive psychiatric dysfunction * suicide intention

Keywords: electric stimulation tilt-table
safety and efficacy studies of rhsa/gcsf fusion protein for injection to treat neutropenia

Conditions: Underdose (Unintentional); Cancer; Tumor

Summary: safety and efficacy studies of rhsa/gcsf fusion protein for injection in treatment of neutropenia induced by chemotherapy of cancer patients.

a dosage climbing for the safety and efficacy studies for the neutropenia induced by chemotherapy cancer patients repeat-dose studies for the safety and efficacy studied for the neutropenia.

Eligibility criteria:
inclusion criteria: - chemotherapy induced neutropenia exclusion criteria: - treated with other biological drugs or other neutropenia therapy drugs

Keywords: neutropenia chemotherapy rhsa/gcsf