Kornimate/medical-research-clean huggingface dataset:
biomechanical assessment of femoroacetabular impingement

Conditions: Femoro Acetabular Impingement

Summary: the purpose of this study is to determine the influence of fai abnormalities on hip joint biomechanics.

the purpose of this study is to quantify hip biomechanics of subjects with and without fai. the results of this study will advance our understanding of how the fai alters the biomechanics of the hip joint, improving diagnosis and directing treatment strategies.

Eligibility criteria:
inclusion criteria: * patients who present with hip pain subsequently diagnosed as femoroacetabular impingement * subjects who meet the following radiographic criterion of cam or pincer fai, will be given the opportunity to volunteer in this study. * subjects that demonstrate a cross-over-sign or a lateral center edge angle (lcea) without an alpha angle, will be classified as having pincer fai. * subjects with an alpha angle, without a cross-over sign or lcea, will be categorized as having cam type fai. * finally, with at least one cam (alpha angle) and pincer sign "cross-over-sign or a lateral center edge angle (lcea)" will be classified as mixed fai. control population inclusion criteria: * 12 controls will consist of volunteers in the same age range as the subject groups (18-35 years). * control hips will be screened with a standard ap radiograph. normal volunteers who have radiographic evidence of fai, dysplasia or other joint deformities will be excluded. exclusion criteria: * subjects who have radiographic evidence of osteoarthritis (tonnis grade iii or iv) will be excluded as this study focuses on the mechanics of hips before prominent cartilage damage. * subjects who have had prior procedures to correct fai or other hip conditions will be excluded (exploratory procedures will be included). * minors (under age 18), mentally disabled, persons incarcerated, on parole, probation awaiting trial, or pregnant women are excluded from this study. * a human chorionic gondaotropin (hcg) urine pregnancy test will be performed on all women prior to the study. * to limit the annual radiation exposure to any participating volunteers, we will exclude anyone who has had a ct scan or participated in a research study involving ionizing radiation in the past 12 months. motion capture exclusion criteria: * subjects who are unwilling or unable to perform the proposed activities of daily living or undergo the clinical exams will be dismissed. * subjects with a bmi less than 30 (www.nhlbisupport.com/bmi/) or those with dense hip musculature/wide hips (maximum of 42 cm of circumferential hip length) will be excluded. ct exclusion criteria: * subjects who are unwilling or unable to remain still. * subjects who are allergic to contrast agent and/or lidocaine will be dismissed.
national registry of cardioneuroablation in recurrent reflex syncope

Conditions: Syncope, Vasovagal; Bradycardia; Heart Arrest

Summary: this registry aims to collect patient data on cardioneuroablation for vasovagal syncope from multiple centers in france. the aim is to evaluate success rates, compare techniques and help institutions set up their own cardioneuroablation program

cardioneuroablation is an emerging technique used to treat patients with vagally-mediated extrinsic bradycardia. it seems particularly efficient in patients with recurrent vasovagal syncope due to a strong cardioinhibitory effect. the procedure consists in using radiofrequency ablation to destroy cardiac ganglionated plexi located in epicardial fat pads around the atrias. key questions concerning this procedure still remain unanswered: 1) what is the success rate of the procedure 2) which patients will benefit from this technique? 3) which fat pads should be targeted during the procedure? 4) what is the best way of identifying the location of these fat pads? 5) what are the long-term effects of this procedure? a multicenter registry seems ideal to try to answer these questions at minimal cost

Eligibility criteria:
inclusion criteria: * patients aged 18 or more * recurrent vasovagal syncope (≥2 episodes during the last year) with an asystolic component (≥3 second pause) recorded during a spontaneous episode. the asystole can be related to sinus arrest or paroxysmal av block. * scheduled cardioneuroablation procedure * estimated residual battery life ≥ 1 year. * patient affiliated to or beneficiary of national health security scheme. * patient who have received an information notice and has not objected to the use of their data in the registry. exclusion criteria: * contraindication to anticoagulation therapy: major bleeding, risk of major bleeding, severe hepatic disease * contraindication to cardiac ct: contrast medium allergies * intracardiac thrombus * patient detained by judicial or administrative decision.

Keywords: cardioneuroablation vasovagal syncope registry
implementation of the families accelerating cascade testing toolkit (factt) for hereditary breast and ovarian cancer and lynch syndrome

Conditions: Hereditary Breast and Ovarian Cancer; Lynch Syndrome

Summary: the purpose of this research study is to learn how cancer care providers can help their patients communicate the need for genetic testing in families with inherited cancer syndromes.


Eligibility criteria:
inclusion criteria: * documentation of hboc or lynch-associated "pathogenic/ likely pathogenic" mutation per american college of medical genetics and genomics criteria (1) * diagnosis of one or more invasive cancers: epithelial ovarian, fallopian tube, primary peritoneal, breast, colorectal, endometrial * mutation listed in nccn guidelines with at least category 2a evidence for intervention * over the age of 18 * psychological ability and general health that permits completion of study requirements and follow-up * willingness to complete follow-up surveys in person, electronically, or by telephone for up to 6 months exclusion criteria: -"variant of undetermined significance," "likely benign" or "benign" variant per acmgg criteria
the effect of unripe carob fruit in celiac patients

Conditions: Celiac Disease

Summary: the aim of this study was to investigate the effects of the consumption of cookies produced by adding the unripe part of carob fruit, which has high insoluble fiber, polyphenol and antioxidant content, on the oxidative parameters (tas and mda), intestinal permeability (zonulin, gip) and microbiota of celiac patients and to develop new products containing unripe carob fruit for celiac patients in this direction.

between 01.02.2022 and 30.05.2022 by specialist dr. orhan sezgi̇n the study will be conducted with 30 volunteers who present to the mersin university faculty of medicine hospital gastroenterology department in mersin.

Eligibility criteria:
inclusion criteria: * have been diagnosed with celiac disease within a maximum period of 1 year, * have not received dietary treatment by a dietitian before * body mass index value between 18.5-25.0 kg/m2, * who have consumed carob fruit and have not had any allergies, * signed the informed consent form, * between the ages of 19 and 64, * who has not had gastrointestinal tract surgery, * without mental disorder, * without inflammatory disease, * no antibiotics or probiotics for the last 1 month, * not taking prescription drugs and/or fiber supplements, * not taking vitamin, mineral supplements, * not during pregnancy and lactation, * without excessive alcohol consumption (\>2 drinks/day) exclusion criteria: * diagnosed with celiac disease for more than 1 year, * have gastrointestinal diseases other than celiac disease, * have previously received dietary treatment by a dietitian, following a diet other than a gluten-free diet, * body mass index values below 18.5 kg/m2 and above 25.0 kg/m2, * who have consumed carob fruit and have had any allergies, * not signing the informed volunteer consent form, * not between the ages of 19-64, * gastrointestinal tract surgery, * with a mental disorder, * with inflammatory disease, * taking antibiotics or probiotics for the last 1 month, * taking prescription medication and/or fiber supplements, * taking vitamin and mineral supplements, * during pregnancy and lactation, * excessive alcohol consumption (\>2 drinks/day)

Keywords: celiac unripe carob antioxidant microbiota
de-implementation of low-value testing in patients undergoing low-risk surgery

Conditions: Breast Lumpectomy; Laparoscopic Cholecystectomy; Inguinal Hernia Repair

Summary: this trial aims to evaluate the effectiveness of a multi-level, multi-component de-implementation strategy to reduce unnecessary preoperative testing. sixteen michigan value collaborative (mvc)/michigan surgical quality collaborative (msqc) sites in michigan will implement several tools that have been proven to reduce unnecessary testing at a single site, including clinician education, a decision aid, audit and feedback on performance, and a pay-for-performance incentive. the researchers believe that, through the use of these strategies, there will be a significant reduction in unnecessary preoperative testing during the intervention.


Eligibility criteria:
site inclusion criteria: * over 30% of testing rates on at least one of the three index procedures (breast lumpectomy, laparoscopic cholecystectomy, and inguinal hernia repair) exclusion criteria: * none surgical participants must be over 18 years old.

Keywords: preoperative testing
comparator trial using insulin glulisine vs. insulin lispro for treatment of gestational diabetes

Conditions: Diabetes During Pregnancy

Summary: we hypothesize that insulin glulisine is non-inferior to currently proven rapid-acting insulin lispro when used in a basal/bolus regimen to treat hyperglycemia in patients with gestational diabetes mellitus.

to date, only two rapid-acting insulin analogs have been shown to be safe and effective for the treatment of diabetes during pregnancy: insulin aspart and insulin lispro. the pharmacokinetics and pharmacodynamics of insulin glulisine are unique and insulin glulisine may be the best rapid-acting analog for the treatment of post-prandial hyperglycemia. we believe that insulin glulisine should be evaluated in women with gestational diabetes for its potential efficacy.

Eligibility criteria:
inclusion criteria: * informed consent to participate in clinical trial * pregnant and 20-30 weeks gestation * diagnosed with gestational diabetes * failed diet therapy (failed lifestyle modification will be defined as 10% or greater smbg values above pre-meal \<90mg/dl and post prandial \< 120mg/dl * eat at least 2 meals per day exclusion criteria: * pregnant women \<18 years old * blood pressure \> 140/80 mmhg * a1c equal to or greater than 6.5% at time of enrollment * pre-pregnancy bmi \> 40kg/m squared * evidence of any fetal anomaly on any fetal ultrasound * currently using hypoglycemic agent * refusal to use insulin before meals * inability to understand instructions or to consent to participate * pregnant women with history of t1dm or t2dm * clinical judgment by investigator that patient is inappropriate for clinical trial or has a metabolic disorder that could interfere with results

Keywords: bolus treatment
recurrence in high-grade lesions after conization

Conditions: Cervical Intraepithelial Neoplasia

Summary: objectives: to identify factors associated with disease recurrence in patients with high-grade cervical intra-epithelial neoplasia (cin) undergoing large loop excision of the transformation zone (lletz). study design: a case-control study that included 103 patients. patients were included in the study if they had a history of surgery for conization by lletz for the histopathological diagnosis of cervical intraepithelial neoplasia grades ii and iii (cin ii and cin iii). follow-up exams were conducted every six months with pap smear collection and colposcopic examination with biopsy, when necessary, for a minimum period of twelve months. cure was defined as a normal follow-up examination within 24 months. during follow-up, relapse occurred when cytology and/or biopsy results showed that cin had returned after 12 months, at which time a new cervical conization by lletz was performed.


Eligibility criteria:
inclusion criteria: 1. history of surgery for conization exclusion criteria: 1. under 18 years of age, 2. immunosuppressed, 3. patient with a histopathological diagnosis of low-grade intraepithelial neoplasia 4. patient with invasion, or surgical margins obtained by lletz that were unable to be evaluated.

Keywords: cervical intraepithelial neoplasia human papillomavirus conization
cross-sectional examination of the reliability of oral implants

Conditions: Periimplantitis

Summary: aim of the multi centrical, cross-sectional study is the registration of the prevalence and incidence of mucositis and periimplantitis.

aim of the multi centrical, cross-sectional study is the registration of the prevalence and incidence of mucositis and periimplantitis. additional clinical examination of the tolerance of titanium using cytosine analysis of periimplant sulcus smear and of blood lymphocytes on titanium plates in vitro. in total 10 centers will examine clinical, genetic and microbiological parameters in 200 patients during 12 months. study hypothesis: the incidence of mucositis and periimplantitis during a time period of 10 years in patients is less than 30%

Eligibility criteria:
inclusion criteria: * patients with oral implants inserted after 01.04.2002 * periodical recall exclusion criteria: * no other titanium implants inside the body

Keywords: peri-implant disease prevalence incidence tolerance titanium
curative effect evaluation of shexiang baoxin pill on coronary artery disease not amenable to revascularization

Conditions: Coronary Artery Disease(CAD)

Summary: the purpose of this study is to determine whether shexiang baoxin pill is effective in the treatment of coronary artery disease not amenable to revascularization on the basis of western medicine therapy.

the western medicine treatment for cad not amenable to revascularization is limited. shexiang baoxin pill, a kind of chinese patent medicine has been used for treating coronary artery disease in clinical practice in china for many years. shexiang baoxin pill(sbp) is applicable to "qi deficiency and blood stasis syndrome" in traditional chinese medicine. recent experimental research has indicated that sbp can improve myocardial ischemia and promote therapeutic angiogenesis.

Eligibility criteria:
inclusion criteria: * participants are aged between 45 and 75 years, diagnosed with sever cad through coronary arteriography which shows that the left main coronary artery and three-vessel have sever diffuse stenosis, calcification or vascular ectasia, be in accordance with traditional chinese medicine syndrome of "qi deficiency and blood stasis syndrome" or "phlegm and stasis mu-tual obstruction syndrome". exclusion criteria: * patients with severe valvular disease, congenital cardiomyopathy decompensation * patients with cad complicated with severe multiple organ disease such as severe heart failure, severe lung, liver or renal dysfunction, peptic ulcer in active stage, or intracranial hemorrhage * patients that use high-dose steroids due to connective tissue disease * patients with serious infections * patients with malignant tumor * patients with hematopoietic diseases * pregnant or lactating women.

Keywords: coronary artery disease revascularization shexiang baoxin pill
the study of aln-ttr02 (patisiran) for the treatment of transthyretin (ttr)-mediated amyloidosis in patients who have already been treated with aln-ttr02 (patisiran)

Conditions: TTR-mediated Amyloidosis

Summary: the purpose of this study is to evaluate the safety and tolerability of long-term dosing with aln-ttr02 (patisiran) in patients with transthyretin (ttr) mediated amyloidosis (attr).


Eligibility criteria:
inclusion criteria: * previously received and tolerated aln-ttr02 (patisiran) in study aln-ttr02-002. * adequate karnofsky performance status, liver function, and renal function. exclusion criteria: * pregnant or nursing. * has had a liver transplant. * has a new york heart association heart failure classification \>2. * has unstable angina. * has uncontrolled clinically significant cardiac arrhythmia.

Keywords: rnai therapeutic
efficacy and safety of auricular acupuncture in depression during the covid 19 pandemic

Conditions: Depressive Symptoms; Depression; Anxiety; Insomnia; Quality of Life

Summary: participants with moderate depressive symptoms measured by phq-9 will be randomized to receive auricular acupuncture. the triple blinded procedure will be conducted in 12 sessions (6 weeks). the primary outcome is the response to the treatment 3 months after inclusion.

depression, often under-diagnosed and under-treated, is the leading cause of disability worldwide and contributes significantly to the global burden of diseases, with university students being a major risk group. there is a growing demand for non-pharmacological treatments for depression. in this sense, auricular acupuncture is considered a simple, low cost technique, well accepted by patients. the unified health system (sistema único de saúde -sus) incorporated this practice in 2006, but there is a lack of studies evaluating its efficacy and safety. the main objective of this study is to evaluate the efficacy of auricular acupuncture to reduce depressive symptoms in comparison with usual care and non-specific auricular acupuncture. this is a randomized clinical trial, blinded to the evaluator, participant and statistician. the study sample will be composed of 280 university students, divided equally into two groups: experimental group - ge (auricular acupuncture) and control group - gc (non-specific auricular acupuncture). the ge and gc participants will be submitted to 12 sessions of auricular acupuncture, 2 times a week. the primary outcome of the study will be the proportion of participants who present improvement of 50% or more in their symptoms, evaluated by the phq-9, three months after inclusion. the secondary outcomes will be: improvement of 50% or more in their symptoms, after six months; quality of life (sf-36), change in the use of antidepressant medication, events and adverse effects, levels of brain-derived neurotrophic factor (bdnf), interleukin 1β, interleukin-6 and tnf-α in blood plasma. the data will be analyzed aiming at treating according to the principles of consort.

Eligibility criteria:
inclusion criteria: * age between 18 and 50 years old * phq-9 score between 10 and 19 (moderate depression) * availability for sessions exclusion criteria: use complementary and integrative practices at the last 3 months; suicidal risk evaluated by question number 9 in the phq-9 severe depression score in the phq-9 prior use of auricular acupuncture pregnancy menopause tape and metal allergy

Keywords: depression auricular acupuncture clinical trial anxiety insomnia quality of life
appetite increase in schizophrenia patients treated with atypical antipsychotics

Conditions: Schizophrenia

Summary: the purpose of this study is to understand, with the use of functional magnetic resonance imaging, the neural correlates involved in appetite control and the mechanism of weight gain in patients with schizophrenia treated with atypical antipsychotics. we hypothesize that a difference in cerebral activations between weight gaining and non-weight gaining patients will be detected after four months of treatment with olanzapine.

atypical antipsychotics (aap) have revolutionize treatment of schizophrenia. they are considered to be more effective in reducing positive and negative symptoms and in improving cognitive deficits. they cause less extrapyramidal symptoms and tardive dyskinesia than typical antipsychotics. they still have a lot of important side effects like sedation, metabolic syndrome and weight gain. these effects could lead to obesity, type ii diabetes and cardiovascular diseases, particularly for schizophrenia patients because they are already at an increased risk for these complications. moreover, an increase in weight gain has been demonstrate to exacerbate negative symptoms and can lead to non compliance with a consequent risk of relapse. it also can create an additional social disadvantage for schizophrenia patients and decrease their quality of life. the weight gain will result, in part from an increased food intake (and probably an increased appetite) and from a decreased energy expenditure. the purpose of this study is to understand the cerebral mechanisms of appetite in patients with schizophrenia treated with atypical antipsychotics to prevent or treat their weight gain.

Eligibility criteria:
inclusion criteria: * patients with schizophrenia (dms-iv) * 18 to 60 years old * right handed * begin a treatment with olanzapine and had not received it for at leat 6 months * other medication accepted (except antipsychotic) exclusion criteria: * concomitant axis-i or axis-ii disorders * unstable medical condition * concomitant antipsychotic medications

Keywords: schizophrenia atypical antipsychotics weight gain appetite fmri
accuracy and primary stability of straight and tapered implants in immediate implant placement using dynamic navigation

Conditions: Tooth Diseases

Summary: prosthetic-driven immediate implant placement for optimal aesthetic restoration has been increasing in demand during the last decades but requires higher accuracy. dynamic navigation has been a reported better implant positioning. there are two main choices of implant macrogeometry: straight and tapered implants. one feature of implant design that may influence implants' accuracy is the taper of the implant body. however, their exact role is still needed to be investigated further. besides, implant macrogeometry may influence primary stability, which is a prerequisite in achieving osseointegration. therefore, we designed a randomized controlled clinical trial study to verify the clinical efficacy of the implant macrogeometry by comparing straight implants with tapered implants in immediate implant placement using dynamic navigation.


Eligibility criteria:
inclusion criteria: 1. ≥18 years old and in good health; 2. the maxillary incisor that cannot be retained due to non-periodontitis; 3. the buccal bone plate is complete; 4. no acute infection; 5. the extraction socket have at least 3-5 mm apical bone. exclusion criteria: 1. general contraindications of oral implant surgery (such as immunodeficiency, long-term use of corticosteroids); 2. treatments or diseases that may affect bone tissue metabolism (for example, taking bisphosphonates or receiving local radiotherapy); 3. periodontitis history or uncontrolled periodontitis. bleeding of probing (bop) positive site ≥ 10%, or probing depth (pd) ≥ 4mm; 4. heavy smokers or previous heavy smoking history (quit smoking time \ 20 cigarettes per day); 5. refuse to participate in this trial.
adherence to exercise and dietary intervention in cancer patients

Conditions: Adherence; Gastrointestinal Cancer

Summary: intervention programs in cancer patients have been proposed with the aim of improving outcome. bearing in mind that compliance is a limiting factor to the benefit provided from exercise and diet, assessing adherence to these interventions is paramount before pursuing further studies. therefore the purpose of this study was to study the adherence of gastrointestinal cancer patients to a combined exercise and dietary intervention (cedi) during neo-adjuvant chemotherapy.


Eligibility criteria:
inclusion criteria: * patients with esophageal, gastric, pancreatic and rectal cancer * due to commence neo-adjuvant chemo/ radiotherapy (cht) exclusion criteria: -

Keywords: body composition wasting malnutrition