Kornimate/medical-research-clean huggingface dataset:
endoscopic mucosal resection (emr) for diagnosis of hirschsprung's disease

Conditions: Chronic Constipation; Hirschsprung's Disease

Summary: the purpose of this study is to compare the diagnostic yield with endoscopic mucosal resection (emr) in hirschsprung's disease versus that of standard rectal suction biopsy. in order to compare emr versus rectal suction biopsy, patients' diagnostic specimens will be analyzed by tissue size, the presence of submucosal tissue, and positive acteylcholinesterase staining. additionally, the proportion of patients who would have required subsequent full thickness surgical biopsy with each technique will be compared. biopsy results will be compared with clinical data including history, bristol stool scale, anorectal manometry results and sitz markers studies. finally, the estimated costs that would have been incurred with each method will be evaluated.


Eligibility criteria:
inclusion criteria: * patients offered a rectal suction biopsy exclusion criteria: * any contraindication to general anesthesia or conscious sedation * contraindication to endoscopy * untreated or unmanageable coaguloapathy * thrombocytopenia (\<50) * inability to provide informed consent.

Keywords: hirschsprung's disease constipation endoscopy, digestive system diagnosis colonoscopy
physical and psychosocial work environmental risk factors of low-back pain

Conditions: Musculoskeletal Disorders; Stress

Summary: background: musculoskeletal disorders, and in particular low-back pain (lbp), are common among blue collar workers. in the work environment, both physical- and psychosocial risk factors exist. working in warehouses in denmark involve large quantities of occupational lifting, high work pace and a low degree of influence at work. this study investigates both acute and long-term associations between physical- and psychosocial work environmental factors and risk of lbp in warehouse workers. the specific study aims are to investigate 1) exposure-response associations between quantity of occupational lifting and short-term (day-to-day) changes in lbp, 2) the influence of accumulated workdays and rest days during a working week on lbp, 3) long-term association between occupational lifting exposure and lbp when assessed over 1 year, and 4) the role of psychological and social factors on the above associations. methods: the present study is designed as a 1-year prospective cohort study that will examine full-time warehouse workers from up to five retail chains in denmark. study aims 1 and 2 will be addressed using objective data based on company records with information on weight of all the goods handled by each warehouse worker during every single workday for 3 weeks. during this period, each worker will reply to text messages received before and after every workday (also on days off work) in which study participants will score their pain in the low back, bodily fatigue and perceived mental stress (scale 0-10). long-term pain development is assessed using questionnaire surveys before and after 1 year. further, pressure pain threshold (ppt) will be measured for selected trunk extensor muscles in approximately 50 workers using algometry along with measurements of maximal trunk extensor strength. associations are modelled using linear mixed models with repeated measures between variables and lbp controlled for relevant confounders. discussion: this study provides knowledge about the acute and long-term associations between physical- and psychosocial work environmental factors and lbp. the obtained data will have the potential to provide recommendations on improved design of the working week to minimize the risk of lbp among warehouse workers, and may potentially enable to identify a reasonable maximum lifting threshold per day (ton lifted/day).


Eligibility criteria:
inclusion criteria: * working ≥30 h per week in a registered retail industry warehouse * ability to read and understand danish or english, * ≥18 years of age. exclusion criteria: * hypertension \> 160/100 mmhg
real-life pan-her-blockade with neratinib

Conditions: Breast Neoplasm

Summary: so far, there is no data available on treatment of patients with early-stage hormone receptor (hr) positive, human epidermal growth factor receptor 2 (her2)-overexpressed/amplified breast cancer, who completed adjuvant trastuzumab-based therapy less than one year ago, in the clinical routine setting. eleanor - designed as a prospective, longitudinal, non-interventional study (nis) - will investigate real-world use of neratinib and its treatment management in patients with hr-positive, her2-overexpressing/amplified breast cancer stage i-iii having completed adjuvant trastuzumab-based therapy less than one year ago. data from this study will contribute to a deeper understanding and characterization of the everyday use of neratinib in a broader patient population in the german and austrian routine setting.


Eligibility criteria:
inclusion criteria: * written informed consent of the patient with regard to the pseudonymized documentation; * legally capable female patient ≥ 18 years of age (no upper limit); * decision was taken to treat the patient with neratinib in accordance with the current smpc and by prescription; this decision was taken prior to and independent from the inclusion into the study; * treatment with neratinib is planned to be started; * hormone receptor (hr) positive, human epidermal growth factor receptor 2 (her2) overexpressing/amplified breast cancer stage i-iii; * completion of prior trastuzumab-based therapy less than 1 year ago; * no signs of relapse before initiation of neratinib treatment. exclusion criteria: * presence of any contraindication with regard to the neratinib treatment as specified in the corresponding summary of product characteristics (smpc); * current or upcoming participation in an interventional clinical trial; * prisoners or persons who are compulsorily detained (involuntarily incarcerated)
healthy kids-houston: a community childhood obesity intervention program

Conditions: Obesity

Summary: the collaborative study is to determine the effectiveness of an after-school community-based program to prevent obesity among minority children.

childhood obesity is a major health issue in the united states, particularly among minority children. an integrated after-school program that offers structured and fun physical activities with nutrition and behavior lessons in community centers operated by the houston parks and recreation department might prevent obesity among minority children who live in the neighborhood.

Eligibility criteria:
inclusion criteria: * live in close proximity of the community centers exclusion criteria: * medical or physical conditions that prevent the child from participating in the physical activities

Keywords: obesity minority children community intervention program lifestyle changes physical activities nutrition lessons behavior modification
platelet rich plasma as an adjunct therapy at the time of transvaginal native tissue prolapse surgery

Conditions: Pelvic Organ Prolapse

Summary: the purpose of the study is to evaluate the surgical outcomes of injecting platelet-rich plasma (prp) into the vaginal tissue as an adjunct therapy at the time of prolapse surgery

platelet rich plasma (prp) is an autologous product with high levels of platelets which are concentrated with bioactive growth factors responsible for accelerating tissue healing by stimulating the number of reparative cells to create collagen production, angiogenesis and neurogenesis. the overarching goal is to evaluate the effectiveness and safety of the adjunct application of prp in the fibromuscular connective tissue (the site of anterior tissue plication) at the time of anterior colporrhaphy (the site of highest recurrence risk) in women undergoing native tissue vaginal prolapse repair, to promote tissue healing and regeneration, thus to improve surgical outcomes.

Eligibility criteria:
inclusion criteria: * desire surgical treatment via a transvaginal native tissue approach. * completed child-bearing exclusion criteria: * unable to follow-up, not willing to, or unable to participate in the proposed study * prior pelvic surgery within the past 12 months * prior anterior/apical suspension procedures * prior graft augmented prolapse surgery * pelvic/abdominal radiation * pelvic mass * history of solid organ malignancy
effect inverse ratio ventilation on arterial oxygenation and respiratory mechanics during lapalar

Conditions: Colorectal Neoplasms

Summary: changes of inspiration: expiration ration from 1:2 to 1:1 could improve the arterial oxygenation and respiratory mechanics

inverse ratio ventilation already known as effective to improve the oxygenation and respiratory mechanics in the ards patients. recently, there were report of decrease in airway pressure and improve in respiratory compliance during inverse ration ventilation undergoing one lung ventilation. we hypothesized that changes of inspiration and expiration ratio from 1:2 to 1:1 could improve the arterial oxygenation and respiratory mechanics in the patients who undergoing laparoscopic low anterior resection. however, prolonged inspiratory time might compromise cerebral perfusion pressure due to an elevation in central venous pressure and concomitant reductions in mean arterial pressure.

Eligibility criteria:
inclusion criteria: * colorectal cancer exclusion criteria: * obesity (bmi\>35), uncontrolled hypertension, coronary artery disease, uncompensated cardiovascular disease, current respiratory disease, open procedure

Keywords: laparoscopy, trendelenburg position, ventilation
prevalence of deficiency of vitamin d in critically ill patients

Conditions: Vitamin D Deficiency; Critical Illness

Summary: vitamin d has been shown to related to clinical outcomes in critically ill patients. the object of this study is to investigate the prevalence of vitamin d deficiency in critically ill patients with various length of icu stay .

studies have revealed that the serum level of 25-hydroxyvitamin d, as known as calcidiol, is low in critically ill patients. the prevalence ranges from 26 to 82%. 25-hydroxyvitamin d deficiency is associated with longer icu stay, higher medical cost and higher death rate in septic patients. 25-hydroxyvitamin d is a kind of hormone related to bone and mineral metabolism. moreover, the receptors were found in almost all cells, and it is related to immune system, cytokine release, cellular proliferation and differentiation, angiogenesis, and muscular energy. the main source is skin metabolism triggered by sunshine and food consumption. it is subsequently converted to calcifediol in the liver and then calcitriol in the kidney (the active form). its serum level is regulated by parathyroid hormone and serum calcium and phosphate. the critically ill patients are deprived of sunshine, suffered from poor nutrition support, impaired liver and kidney function, higher rate of consumption, and are under higher risk of deficiency. nowadays, the studies about 25-hydroxyvitamin d in icu patients were conducted mostly in europe and america. there is no large-scale study in taiwan or asia. a randomized controlled study from austria has shown large dose supply in patients with 25-hydroxyvitamin d deficiency could decrease the mortality. the object of this multi-center study is to investigate the prevalence of 25-hydroxyvitamin d deficiency, the risk factors and the correlation with outcomes. the results could be a step-stone for future randomized controlled studies.

Eligibility criteria:
inclusion criteria: * all icu patients exclusion criteria: * 1, less than 20 years 2, bmi \< 18 kg/m\^2 3, had large dose vit d within previous four weeks (over 3000 iu per day) 4, icu admission within previous three months 5, have disease affecting vit d level, calcium metabolism, bone metabolism such as parathyroid disease, rickets, liver cirrhosis child c 6, communication difficulty

Keywords: vitamin d deficiency critical illness
crd007 for the treatment of abdominal aorta aneurysm (the aorta trial)

Conditions: Abdominal Aortic Aneurysm

Summary: this is an investigation of the efficacy and safety of crd007 compared to placebo in the treatment of patients with abdominal aortic aneurysm.


Eligibility criteria:
inclusion criteria: * infra-renal abdominal aortic aneurysm exclusion criteria: * previous infra-renal aortic surgery * known diabetes
ischemia time and graft survival

Conditions: Liver Transplant

Summary: study the effect of ischemia time on patient and graft survival.

study the effect of cold ischemia and warm ischemia on graft function after one year and patient one year survival.

Eligibility criteria:
inclusion criteria: * recipients of living donor liver transplantation exclusion criteria: * early mortality

Keywords: liver transplant recipient
therapeutic recommendations for nephroblastoma

Conditions: Nephroblastoma

Summary: the study is based on results form 2 previous studies carried out by the gfaop. the aim of this study is to evaluate the capacity of units to follow the recommendations in the protocol.

the study is based on results form 2 previous studies carried out by the gfaop. this study aims to evaluate the capacity of units to follow the recommendations in the protocol. it will look mainly at treatment compliance and outcome for the children treated. the study will also evaluate the improvement in treatment compliance and reporting. this work will help the group to evaluate future needs in participating units and help us adapt treatment programmes to local conditions.

Eligibility criteria:
inclusion criteria: unilateral nephroblastoma tumor not previously treated the general health of the child will permit treatment. . exclusion criteria: bilateral nephroblastoma tumor previously treated disease too advanced doubt concerning the diagnosis treatment refusal
hyperspectral imaging in thoracic surgery

Conditions: Bronchus Anastomosis; Bronchus Stump; Tissue Oxygenation

Summary: the aim of this study is to find out whether hyperspectral imaging enables bronchus stump and bronchus anastomosis oxygenation.

the bronchus before lung resection and the bronchus stump or bronchus anastomosis, respectively, are investigated. the hyperspectral imaging camera head is placed and aligned over the surgical (camera and object distance: 30 cm for all measurements). the field of view is illuminated by 8 halogen spots (20 w each) and 100 wavelengths in the wavelength range from 500 to 1000 nm were applied. the software calculates the tissue oxygenation \[%\] , organ-hemoglobin-index, near-infrared-index and the tissue-water-index of the investigated tissue. the study was designed to investigate tissue oxygenation in the superficial (app. 1mm) and deeper layers (app. 4-6mm) of the bronchus before and after lung resection.

Eligibility criteria:
inclusion criteria: * lung resection or other resection via thoracotomy exclusion criteria: * restriction of the ability to consent
improving congenital heart disease care

Conditions: Congenital Heart Disease; Behavior, Health; Quality of Life; Empowerment, Patient; Activation, Patient

Summary: the theory-informed digital health intervention, called as "empower my congenital health (empowermych)" aims to activate and engage achd patients in building confidence toward navigating the adult healthcare system. this tool is built after incorporating the theories of behavior change, gathering inputs from target patients in all stages of its design and implementation. the key features of the tool include a digital medical passport, updated congenital information, community support, and patient stories and advice. the investigators aim to test the acceptability, feasibility, efficacy, and effectiveness of the intervention.

the goal of this clinical trial study is to learn whether a digital multi-component intervention would increase the knowledge, self-efficacy, self-advocacy, and patient engagement skills of adults with congenital heart disease (chd) to confidently navigate the health care system and have timely recommended specialist visits. the multicomponent intervention contains features such as a digital medical passport, updated health-related specific information, opportunities to engage with chd community, peer-support, doctor visit reminders, etc. the intervention components are designed with inputs from the patients and the chd community and have the potential to be adapted on an ongoing basis depending on the needs of the patients. the main question it aims to answer is: does the digital multi-component chd patient engagement intervention enhance the patient engagement skills and lead to timely specialist visit? participants will be recruited from the clinics, through word of mouth, social media, and others. participants can use the website link or a qr code to sign an electronic consent form to be eligible to participate. once consented, the participants will receive surveys to collect baseline and health status information as well as intervention components at regular intervals. the study will be available for participants to join on the web or mobile, depending on their preferences.

Eligibility criteria:
inclusion criteria: * have congenital heart disease * 18 years or older * can sign the informed consent exclusion criteria: * developmentally delayed * unable to consent
effects of wb-ems and high protein diet in ibd patients

Conditions: Inflammatory Bowel Diseases

Summary: patients with inflammatory bowel disease (ibd) often suffer from muscle weakness and a low bone mineral density as a consequence of systemic inflammation and disease treatment limiting quality of life in a considerable way. exercise interventions to build up muscle mass and increasing physical function are promising tools to improve the whole muscular status of those patients. however, in the acute phase of ibds conventional training methods may be too strenous, also because patients are suffering from acute gastrointestinal symptoms and feel fatigued. due to those symptoms, patients present low food intake and great loss of nutrients and energy especially by diarrhea. individualized nutritional support may be helpful to avoid malnutrition. the aim of this pilot study is to investigate the effect of a combined exercise and nutrition intervention using the gentle training method of whole-body electromyostimulation (wb-ems) combined with a individual high protein nutritional support on muscle mass, body composition, physical function, quality of life and gastrointestinal symptoms in outpatients with ibd.


Eligibility criteria:
inclusion criteria: * outpatients with inflammatory bowel disease (crohn's disease, ulcerative colitis) * adults (18 years and older) exclusion criteria: * simultaneous participation in other nutritional or exercise intervention trials * acute cardiovascular events * use of anabolic medications * epilepsy * severe neurological diseases * skin lesions in the area of electrodes * energy active metals in body * pregnancy * acute vein thrombosis

Keywords: muscle weakness muscle mass whole-body electromyostimulation wb-ems nutrition protein crohn's disease ulcerative colitis
a study of hydroxychloroquine, vitamin c, vitamin d, and zinc for the prevention of covid-19 infection

Conditions: COVID-19; Coronavirus Infection; Sars-CoV2; Corona Virus Infection; COVID; Coronavirus; Coronavirus-19; Coronavirus 19

Summary: this is a phase ii interventional study testing whether treatment with hydroxychloroquine, vitamin c, vitamin d, and zinc can prevent symptoms of covid-19

in this study, subjects will take a regimen of hydroxychloroquine, vitamin c, vitamin d, and zinc to test if this combination can prevent covid-19. treatment with hydroxychlorquine will last 1 day. treatment with vitamin c, vitamin d, and and zinc will last 12 weeks. the study will last 12 weeks.

Eligibility criteria:
inclusion criteria: 1. informed consent, provided electronically via the edc, demonstrating the subject understands the procedures required for the study and the purpose of the study 2. male or female patients 18 years of age or older that are considered to be high-risk individuals. a. high-risk individuals are defined as all health care workers in hospitals, clinics, and emergency rooms, and medical facilities. 3. subjects must agree to practice at least two highly effective methods of birth control for the duration of the study this includes condoms with spermicide, oral birth control pills, contraceptive implants, intra-uterine devices, or diaphragms. at least one of these must be a barrier method. subjects not of reproductive potential will be exempt (e.g. post-menopausal, surgically sterilized) exclusion criteria: 1. refusal to provide informed consent 2. any previous positive test for covid-19 by rt-pcr 3. symptomatic for covid-19 4. diarrhea prior to the start of treatment 5. type i or ii diabetes 6. atherosclerotic coronary artery disease 7. any contraindication for treatment with hydroxychloroquine including: 1. hypoglycemia 2. g6pd deficiency 3. porphyria 4. anemia 5. neutropenia 6. alcoholism 7. myasthenia gravis 8. skeletal muscle disorder 9. maculopathy 10. changes in the visual field 11. liver disease, with alt/ast \> 2.5 upper limit normal and total bilirubin \>2.5 upper limit normal 12. psoriasis 13. any contraindicated medications found in appendix 2 8. any comorbidities which, in the opinion of the investigator, constitute health risk for the subject. 9. vaccination for sars-cov-2
cognition and neuroimaging in neurodegenerative disorders (cognid)

Conditions: Dementia (Diagnosis)

Summary: this prospective study aims: 1. to compare cognitive performance in different clinical groups of participants with mild cognitive impairment (mci) or mild dementia \[alzheimer's disease (ad), vascular cognitive impairment (vci) and fronto-temporal dementia (ftd)\] to determine whether scores reveal differential profiles between the groups, 2. to demonstrate differences in imaging markers between different dementia syndromes and healthy volunteers using ultra high-field mri at 7t.

the imaging arm of the study include: 1. to demonstrate differences in brain iron levels between different dementia syndromes and healthy volunteers using ultra high-field mri, quantitative susceptibility mapping (qsm) at 7t. 2. to demonstrate variations in the resting oxygen usage as an important biomarker to discriminate between different dementia syndromes. 3. to demonstrate cerebral blood flow changes in the brain, particularly in the hippocampus region, and its correlation with different dementia syndromes using arterial spin labelling mri technique. 4. to demonstrate increased blood brain barrier leakage in the brain, particularly in the hippocampus region, and its correlation with alzheimer's disease (ad) and vascular cognitive impairment (vci) using a new dynamic contrast-enhanced mri (dce-mri) technique.

Eligibility criteria:
inclusion criteria: 1. ability to give informed consent. 2. either pathological, genetic or imaging biomarker evidence to suggest fronto-temporal lobar degeneration, alzheimer's disease or vascular cognitive impairment, or defined clinical diagnoses. exclusion criteria: 1. lack of mental capacity to consent to study involvement. 2. not speaking english before age 5 years. 3. learning disability. 4. mri contraindications
tightrope fixation of acromioclavicular joint dislocation - a prospective series

Conditions: Acromioclavicular Joint Dislocation

Summary: several surgical techniques are used for the treatment of acute acromioclavicular joint dislocations. the investigators investigate a new method using arthroscopic repair using the tightrope fixation device.

the tightrope consists of a suspension system with a strong suture thread intertwined between an oval button and a round button, which is inserted through drilling holes in the clavicula and the coracoid. the investigators want to prospectively evaluate the results in a series of 25 patients.

Eligibility criteria:
inclusion criteria: * acute acromioclavicular joint dislocation * 18 years or older exclusion criteria: * unable to sign informed consent

Keywords: acromioclavicular injury dislocation surgery