Kornimate/medical-research-clean huggingface dataset:
automatic segmentation of polycystic liver

Conditions: Polycystic Liver Disease; Polycystic Hepatorenal Disease; Liver Injury

Summary: assessing the volume of the liver before surgery, predicting the volume of liver remaining after surgery, detecting primary or secondary lesions in the liver parenchyma are common applications that require optimal detection of liver contours, and therefore liver segmentation. several manual and laborious, semi-automatic and even automatic techniques exist. however, severe pathology deforming the contours of the liver (multi-metastatic livers...), the hepatic environment of similar density to the liver or lesions, the ct examination technique are all variables that make it difficult to detect the contours. current techniques, even automatic ones, are limited in this type of case (not rare) and most often require readjustments that make automatisation lose its value. all these criteria of segmentation difficulties are gathered in the livers of hepatorenal polycystosis, which therefore constitute an adapted study model for the development of an automatic segmentation tool. to obtain an automatic segmentation of any lesional liver, by exceeding the criteria of difficulty considered, investigators have developed a convolutional neural network (artificial intelligence - deep learning) useful for clinical practice.


Eligibility criteria:
inclusion criteria: * patients ≥ 18 years old * patients with hepato-renal polycystosis, with or without surgery * patients with at least one abdominal-pelvic ct scan without injection or with injection between january 1, 2016 and august 2018 * patients with good quality and available images exclusion criteria: * patients with no ct scan images available * patients with bad quality of ct scan images
the relationship between the spi and the postop ed

Conditions: General Anesthesia

Summary: surgical plethysmography index (spi) is a device that can noninvasively monitor the balance between the nociception and ant-nociception using pulse photoplethysmographic amplitude (ppga) and heart rate obtained through an oxygen saturation measuring device. spi has recently been studied as a useful tool to monitor the stress response of patients due to surgery or anesthesia and to guide the appropriate use of analgesics/anesthetics. however, these spi devices have been developed for adults and have not been studied in pediatric patients with relatively high heart rates, and no direct effects on post-operative arousal excitability have been reported.


Eligibility criteria:
inclusion criteria: * pediatric patients aged 2-7 years with an american society of anaesthesiologists physical status (asa ps) of 1 or 2, who were planned to undergo ophthalmology surgery requiring general anesthesia. exclusion criteria: * asa ps 3 or 4 * presence of developmental delays or neurological diseases * history of allergies or contraindications to the use of ketamine (increased intracranial pressure, open-globe injury, or a psychiatric or seizure disorder) * treatment with beta-receptor blockers, beta-receptor agonists or any other drug suspected to interact with the sympathovagal balance * diseases with impairment of sensitivity (diabetes, polyneuropathy, peripheral arterial obstructive disease et etc) * pacemaker therapy * dermal diseases with the affection of the forearm/hand

Keywords: emergence delirium pulse oximetry children, preschool
dry needling, manipulation and stretching vs. manual therapy, exercise and ultrasound for lateral epicondylalgia

Conditions: Lateral Epicondylitis

Summary: the purpose of this research is to compare two different approaches for treating patients with lateral epicondylalgia: electric dry needling, thrust manipulation and stretching versus impairment-based manual therapy, exercise and ultrasound. physical therapists commonly use all of these techniques to treat lateral epicondyalgia. this study is attempting to find out if one treatment strategy is more effective than the other.

patients with epicondyalgia will be randomized to receive 2 treatment sessions per week for 4 weeks (up to 8 sessions total) of either: (1) electric dry needling, thrust manipulation and stretching or (2) impairment-based manual therapy, exercise and ultrasound

Eligibility criteria:
inclusion criteria: 1. adult between 18 and 60 years old that is able to speak english. 2. report of at least 6 weeks of elbow (i.e. lateral epicondyle) and dorsal forearm pain, consistent with lateral epicondylitis: 3. patient has not had physical therapy, massage therapy, chiropractic treatment or injections for elbow pain in the last 6 months: 4. diagnosis of lateral epicondylitis, defined as two of more of the following: 1. pain on palpation over the lateral epicondyle and the associated common extensor unit 2. pain on gripping a hand dynamometer 3. pain with stretching or contraction of the wrist extensor muscles exclusion criteria: 1. report of red flags to manual physical therapy to include: severe hypertension, infection, uncontrolled diabetes, peripheral neuropathy, heart disease, stroke, chronic ischemia, edema, severe varicosities, tumor, metabolic disease, prolonged steroid use, fracture, ra, osteoporosis, severe vascular disease, malignancy, etc. 2. report of previous surgery of the elbow, history of elbow dislocation, elbow fracture and/or tendon rupture 3. report of systemic neurological disorders and/or neurological deficits to include the following: 1. nerve root compression (muscle weakness involving a major muscle group of the upper extremity, diminished upper extremity deep tendon reflex, or diminished or absent sensation to pinprick in any upper extremity dermatome) 2. cervical spinal stenosis (exhibited bilateral upper extremity symptoms) 3. central nervous system involvement (hyperreflexia, sensory disturbances in the hand, intrinsic muscle wasting of the hands, unsteadiness during walking, nystagmus, loss of visual acuity, impaired sensation of the face, altered taste, the presence of pathological reflexes) 4. history of whiplash injury within the previous 6 weeks 4. history of surgery to the head/neck or affected upper extremity. 5. psychiatric disorders or cognitively impaired 6. pregnancy
sutent maintenance after response to taxotere

Conditions: Prostate Cancer; Hormone Refractory

Summary: the major goal is to determine whether the experimental agent has clinically promising activity that would merit progression to a formal phase iii trial. patients with hormone refractory prostate cancer after docetaxel chemotherapy have limited treatment options and no systemic treatment has been proven to be effective. because of its action, safety and simple administration su011248 has potential for effectiveness in this disease setting. promising activity in this study would provide the necessary proof-of-principle for a larger confirmatory study in this population, and potentially in earlier stages of this common disease.


Eligibility criteria:
inclusion criteria: * histological or cytological diagnosis of adenocarcinoma of the prostate * metastatic or locally recurrent disease not curable with standard therapy * ecog performance status 0, 1 or 2 * prior single agent docetaxel or docetaxel combination chemotherapy with a documented psa or imaging response, and no objective evidence of disease progression at study enrolment exclusion criteria: * patients with a history of other invasive cancer, except adequately treated non * melanoma skin cancer. * patients with known brain metastases. * history of allergic reactions attributed to compounds of similar chemical or biologic composition to su011248. * other serious intercurrent illness or medical condition that might be aggravated by protocol treatment.

Keywords: sutent
phase 1 study investigating effects of htl0009936 on cognition and bold fmri signals in healthy elderly subjects

Conditions: Alzheimer's Disease

Summary: to determine if treatment with htl0009936 will lead to changes in neural activity, measured using the fmri bold signal and asl, in brain areas that are associated with spatial and working memory, learning and executive functioning.


Eligibility criteria:
inclusion criteria: * healthy on the basis of medical history, physical examination, vital signs, 12-lead ecg, haematology, blood chemistry, urinalysis and a pre-study psychological assessment. * mini mental state examination (mmse) score of ≥24. * intermediate or extensive metaboliser as determined by cyp2d6 genotype. * fluent english speaker. * right-handed. * not a regular smoker exclusion criteria: * recreational drug use within 3 months prior to screening visit. * positive alcohol breath test. * positive urine drug screen. * consumption of large amounts of caffeinated drinks. * consumption of any food or any drinks containing cranberry, pomegranate, star fruit, grapefruit, pomelos, exotic citrus fruits or seville oranges. * ultra-rapid or poor metabolizer as determined by cyp2d6 genotype. * by self-report, taking two or more daytime naps per week which in the opinion of the investigator is likely to interfere with the ability of the subject to complete the study procedures. * history of, or presents (in the opinion of the investigator) with, significant neurological or psychiatric conditions. * personal or family history of congenital long qt syndrome or sudden death. * concomitant use of drugs that are metabolised by and/or are inhibitors of cyp2d6. * concomitant use of drugs that are substrates for the organic cation transporter 2. * history of significant claustrophobia. * fulfils any of the mri contraindications on the standard site radiography screening questionnaire (e.g. history of surgery involving metal implants).
webnovela for hispanic dementia family caregivers

Conditions: Alzheimer's Disease; Dementia

Summary: photozig and stanford university are creating a new program for hispanic dementia caregivers to help cope with caregiving, alleviate related stress, and enhance quality of life for caregivers, with funding from the national institute on aging. the program includes a new education online telenovela (webnovela), online resources, handouts and a dvd (for users without internet) on how to deal with caregiving stress and handle difficult situations.

the goal of webnovela program is to evaluate and develop materials for helping caregivers to cope with caregiving, alleviate related distress, and improve their quality of life. the investigators are evaluating different materials, which may provide caregiving strategies, practical tips and help to enhance caregivers' skills to deal with demanding tasks of caregiving, alleviate related stress, and improve quality of life. research program steps: 1. caregivers will be asked some simple questions about themselves and their family members to see if they are eligible for the project (fill out enrollment form and informed consent). 2. a program survey will be sent, which can be completed online, or returned in a pre-mailed envelope. 3. participants will receive links to online resources, related materials and instructions. the investigators ask participants to access the online resources, read provided brochures and guides, and follow the instructions. materials are expected to help participants in their caregiver role. 4. after completing the program, the second and final survey should be filled out online or returned by pre-mailed envelope.

Eligibility criteria:
inclusion criteria: * care for an individual with alzheimer's disease or other dementia. * have internet access or own a dvd player. * minimum age of 18 years old. * belong to hispanic/latino ethnic group. * spend at least 8 hours/week caring for a person with dementia, which may include assisting, watching, monitoring, or being available to help (e.g. during sleep time) exclusion criteria: * severe psychological or physical illness. * inability to read and follow spanish instructions. * high level of depressive symptoms. * unwillingness to participate in all aspects of the study.

Keywords: alzheimer's disease dementia caregiving caregiver coping coping with caregiving stress hispanic caregiver latino caregiver
application of 68ga-labeled cd73 targeting probe pet/ct imaging in the diagnosis of malignant tumor

Conditions: Tumor Immunity

Summary: 68ga-dota-dpne pet/ct imaging was performed on patients with malignant tumors to observe the binding of lesions with the tracer and evaluate the expression of cd73. at the same time, correlation analysis was performed combined with relevant clinical indicators to evaluate the efficacy of 68ga-dota-dpne in the diagnosis and guidance of malignant tumor patients, and predict the response of targeted therapy.


Eligibility criteria:
inclusion criteria: * 1: age: ≥18 years, expected survival ≥12 weeks 2: without radiotherapy and chemotherapy, surgery or biopsy is feasible to obtain pathological diagnosis 3: standard solid tumor response evaluation criteria (recist) version 1.1 with at least one measurable target lesion 4: obtain written informed consent and be able to follow up exclusion criteria: - 1: severe liver and kidney dysfunction. 2: women who are planning to conceive, pregnant, or breastfeeding, as well as those planning to have children during the study period, are not eligible to participate in this research. women of childbearing potential must use effective contraception throughout the course of the study. 3: individuals unable to lie flat for thirty minutes. 4: suffers from claustrophobia or other mental illnesses 5: researchers believe that the subject has other conditions that make them unsuitable for inclusion in this study 6: refuses to join this clinical study
comparison of two hysteroscopy approaches

Conditions: Menorrhagia

Summary: this randomized clinical trial compares two methods of diagnostic hysteroscopy: vaginoscopic hysteroscopy vs. traditional method. pain intensity was estimated using a visual analogue scale (vas), and patient satisfaction was evaluated. these endpoints were compared by treatment assignment. vaginoscopic hysteroscopy was associated with significantly lower vas scores, indicating reduced experience of pain in this treatment group; however, this was not associated with improved patient satisfaction.

objective: to compare the vaginoscopic approach of diagnostic hysteroscopy without anesthesia with the traditional diagnostic hysteroscopy after intracervical injection of mepivacaine hydrochloride 3%. methods: a total of 130 women undergoing diagnostic hysteroscopy were included in the study and were randomized, using a computer-generated randomization list, into two groups with a ratio of 2:1. eighty three women underwent vaginoscopy without speculum, tenaculum or anesthesia. forty seven women received intracervical anesthesia with 10 ml of 3% mepivacaine hydrochloride solution injected at two sites (3:00 and 9:00 positions) and underwent traditional hysteroscopy using a speculum and tenaculum. hysteroscopy was performed using a rigid 3.7 mm hysteroscope in a medium of 0.9% saline, and the image was transmitted to a screen visible to the patient. a visual scale analogue (vas) consisting of a 10 cm line was used to assess the intensity of pain experienced during and after the procedure. overall patient satisfaction was assessed during, immediately after, 15 minutes later, and three days post hysteroscopy. results: the mean pain score was significantly lower in the vaginoscopy group (3.8±2.7 vs 5.34±3.23, p=0.01). patient satisfaction rate was similar in both groups. conclusion: patients reported significantly less pain with the vaginoscopic approach to diagnostic hysteroscopy even without anesthesia compared to patients undergoing the traditional procedure with anesthesia. this new approach should therefore be considered as a replacement for the traditional hysteroscopic technique.

Eligibility criteria:
inclusion criteria:adult female, referred for outpatient diagnostic hysteroscopy, subscriber to maccabe health maintenance organization - exclusion criteria:heavy vaginal bleeding; severe cervical stenosis; patients refusing the examination on an outpatient basis. -

Keywords: menorrhagia intrauterine diagnosis visual analogue scale
study to evaluate if inhaled nitric oxide improves liver function after transplantation

Conditions: Reperfusion Injury; Liver Injury

Summary: this blinded, placebo-controlled study will administer inhaled nitric oxide to patients undergoing liver transplantation. the purpose of the study is to test if inhaled nitric oxide prevents liver injury associated with the restoration of blood flow. the premise of the current study is provided by previous studies which document a protective effect of inhaled nitric oxide in this clinical setting.

specifically, presenting ischemia-reperfusion injury to transplanted livers remains a therapeutic goal in improving liver function and potentially expanding the number of transplantable livers. this study aims to assess the efficacy of inhaled nitric oxide to limit ischemia-reperfusion injury in transplanted livers and by doing so improve liver function post transplantation and decrease patient hospital length of stays.

Eligibility criteria:
inclusion criteria: * patients \> 19 yr of age scheduled to undergo liver transplantation. exclusion criteria: * patients \< 19 yr of age * patients undergoing re-transplantation or dual organ transplantation * patients with underlying pulmonary complications

Keywords: ischemia-reperfusion nitric oxide inflammation cell-death liver-function post transplantation
lsfg in patients with normal tension glaucoma tension glaucoma

Conditions: Glaucoma, Primary Open Angle

Summary: glaucoma is the second leading cause of blindness worldwide. literature shows increasing evidence that dysfunction of ocular microcirculation in the optic nerve influences the progression of glaucoma. laser speckle flowgraphy (lsfg) represents a non-invasive method to quantify ocular perfusion also at the onh. lsfg enables noninvasive quantification of microcirculation of the optic disc in japanese glaucoma patients


Eligibility criteria:
inclusion criteria: * caucasian men and women aged over 50 years * subject is generally healthy with no current significant or a history of a significant neurological, cardiovascular, pulmonary (including asthma), hepatic, metabolic, rheumatic, autoimmune, hematological or renal disorder, as determined by the investigator's clinical judgment through collection of medical history and performance of a physical examination. a significant disorder is defined as a disease or medical condition associated with impaired health status, requiring regular or current medical treatment and/or follow up. for the purposes of this study, an investigator may classify a medical condition as a nonsignificant disorder despite the fact that the subject receives treatment. subjects having controlled stage 1 hypertension (blood pressure of 140-159 mmhg systolic and/or 90-99 mmhg diastolic) are eligible for participation in this study * normal open angle in a gonioscopic examination * presence of glaucomatous optic disc changes in biomicroscopy and * visual field defects in at least two visual field examinations (reliability criteria: fixation errors \< 20%, false positives \< 15%, and false negatives \< 33%) or * abnormal circumpapillary retinal nerve fiber layer thinning (rnfl evaluated by oct) exclusion criteria: * history of ocular or systemic disease causing optic nerve damage * history of iop greater than 21 mm hg (corrected by cct) * participation in a clinical trial in the 3 weeks preceding the study * ocular surgery (including intravitreal injection) during the 3 months preceding the study * ametropia \> 6 dpt * smoking * pre- or perimenopausal women * relevant ophthalmic diseases/conditions that could interfere with lsfg measurements (e.g. optic nerve head drusen, tilted disc, etc.) * opacities of the cornea (e.g. corneal scars, corneal oedema), the lens (e.g. locs-ii grading \> 2, posterior capsule opacification) or the vitreous (e.g. vitreous haemorrhage, asteroid hyalosis) * patients who are not able to cooperate or with insufficient ability to fixate (tremor, nystagmus) * blood donation in the 3 weeks preceding the study * symptoms of a clinically relevant illness in the 3 weeks before the first study day * ocular infection or clinically significant inflammation * pregnancy, planned pregnancy or lactating
group o whole blood : storage lesion impact and inflammation

Conditions: Blood Donation; Blood Platelets; Blood Donors; Inflammation; Transfusion

Summary: "etablissement français du sang" (efs) prepares labile blood products from blood donations that are separated by type (red blood cells, plasma and platelets). the "centre de transfusion sanguine des armées" (ctsa) produces an innovative labile blood product, lto-wb, corresponding to group o leukocyte-free whole blood. the objective of the pedestal efs study is to compare the inflammatory and biological characteristics of blood products prepared by the efs vs. the labile blood product prepared by the ctsa.

hemorrhage is one of the main causes of preventable death among soldiers in combat. currently, the majority of patients receive blood components (red blood cells, platelets, plasma) rather than whole blood. these factors lead doctors deployed on external operations (opex) to use plasma, rbcs and platelets. however, platelet concentrates may not be available on missions, as their storage conditions and shelf life are not always compatible with opex logistics. the only solutions to this problem is to use group o leucocyte-depleted whole blood without hemolysin (or low titer o whole blood, ltowb), which provides the three elements in physiological proportions. however, while studies have shown this product to be effective in stopping bleeding, its inflammatory potential, linked to the presence of platelets, has not yet been investigated. indeed, in addition to their hemostatic role, platelets are also involved in inflammation. the main objective of our research project is to deploy in vitro and in vivo tools to compare ltowb, focusing on its inflammatory component with conventional and well-mastered transfusion products for (1) platelet-related inflammation (ltowb vs. buffy coat pooled platelet concentrate or single donor apheresis platelet concentrates), (2) rbc-related inflammation (ltowb vs. rbc concentrates) and (3) other circulating inflammatory molecules (ltowb vs. fresh frozen plasma). the definition of biomarkers is essential to optimize the use of these products, depending on the therapeutic indication. linking these biomarkers with the effectiveness of transfusions will help to determine the risk/benefit ratio of transfusions that may be required in rural and austere environments, such as opex in comparison to civilian transfusion medicine.

Eligibility criteria:
inclusion criteria: self-referred donors eligible for blood donation (whole blood and/or platelet/plasma apheresis), meeting the following inclusion criteria: * be in good health * weigh at least 50 kg * must be between 18 and 70 years of age for whole blood donation and between 18 and 65 years of age for plasma/platelet donation by apheresis. exclusion criteria: subjects ineligible to donate blood

Keywords: blood lto-wb characterization of labile blood products whole blood apheresis plasma platelet red blood cells inflammation transfusion