Kornimate/medical-research-clean huggingface dataset:
analysis of neurocognitive elements of attention after chemotherapy

Conditions: Cancer Nos

Summary: data for this study will be obtained from the university of texas southwestern medical center simmons comprehensive cancer center. participants will be recruited through simmons cancer center. one hundred female breast cancer patients who have completed adjuvant chemotherapy will be enrolled. in order to reach this number, it is estimated that up to 125 eligible participants will need to be recruited. the study will last approximately two years. participants will undergo one cognitive testing session, and each subject's total participation time will last no more than two hours.

the study visit will be scheduled for three to six months after completing adjuvant chemotherapy treatment. at the study visit, informed consent will be obtained and neurocognitive attention testing will be performed. the assessments chosen were carefully selected based on breadth, psychometric properties, standardized broad clinical use, good external validity and time efficiency. the testing time for the battery of neuropsychological tests is approximately 45-60 minutes. participants will also be asked to complete a packet of several questionnaires including several self-rated measures of mood and quality of life, in addition to a brief questionnaire to obtain information about exercise, sleep, and education and employment backgrounds. it is estimated that questionnaire completion will require no more than 30 minutes. participants will be seen on only one occasion, and may receive, upon request, written feedback about the results of the evaluation.

Eligibility criteria:
inclusion criteria: * women; * diagnosed with breast cancer stages i-iv; and * completed a treatment regimen of adjuvant chemotherapy three to six months prior to evaluation. patients may be receiving anti-hormonal treatment. all subjects will be native speakers of english who have a minimum of a high school education (or ged equivalent) in order to ensure the validity of the neuropsychological tests that will be administered. in order to limit age effects, participants will be between the ages of 40 and 70 years. exclusion criteria: * subjects with a previous history of stroke, head injury with loss of consciousness greater than 30 minutes, major surgeries within the past 6 months unrelated to their breast cancer treatment, pre-cancer major axis i psychiatric disorder, diagnosis of adult attention deficit disorder, or other pre-existing disorder with known cognitive impairments (e.g. dementia, intellectual disability) will be excluded. * non- english speakers and subjects under the age of 40 or over the age of 70 will not be included.
outcomes of children with congenital single ventricle heart

Conditions: Congenital Disorders

Summary: congenital heart disease affects 1 in 100 newborn babies each year and more than 2,000,000 americans have a congenital heart defect. one common defect treated at children's healthcare of atlanta at egleston is single ventricle heart. due to these overwhelming numbers, the use of diagnostic imaging technology to assess these defects and heart function is an important step in the evolving care of this patient group.

the definition of single ventricle can mean a ventricle that is hypoplastic, too small, or completely absent. either the right or left ventricle may be affected. there may also be other cardiac anomalies present. infants with a single ventricle develop distress after birth when the ductus arteriosus and foramen ovale close. this may happen within hours or days of delivery. the severity of symptoms is determined by the degree of defect. but, single ventricle patients will not survive without treatment. patients with only one functioning ventricle can usually expect either a heart transplant or a series of palliative surgeries or sometimes both. their care is very complex requiring a team of dedicated practitioners to manage drug therapy, medical support and surgery. at children's healthcare of atlanta at egleston, it is standard of care for a patient with a single ventricle heart to undergo many non-invasive imaging studies and sometimes invasive studies such as heart catheterization. results of the studies provide valuable information used for treatment decisions and evaluation of heart function. we propose to do a retrospective chart review of patient data including a review of their invasive and non-invasive studies.

Eligibility criteria:
inclusion criteria: * single ventrical heart exclusion criteria: * those patients who do not have single ventrical heart

Keywords: pediatric cardiac single ventricle
effect of hippotherapy and schroth exercise on pulmonary function and aerobic capacity in idiopathic scoliosis

Conditions: Scoliosis Idiopathic

Summary: background: idiopathic scoliosis has been identified as a common spinal malalignment that negatively impacts the respiratory system and physical conditioning in adolescents. hippotherapy is an equestrian intervention that optimizes physical performance and mobility in a bunch of contexts; however, its influence on pulmonary function remains unclear. aim: this research aimed to analyze the impact of ten weeks of hippotherapy combined with schroth exercises on ventilatory function and aerobic capacity in ais. design: randomized controlled trial setting: outpatients attend a single center that includes a rehabilitation room and recreational riding center. population: forty-five patients were arbitrarily recruited to the experimental (n= 22) and control group (n=23). methods: patients in the experimental group received 30 minutes of walking and sitting trot training, 15 sessions split into 2 phases over ten weeks. the two groups attended a 60-minute session of schroth's intervention, 3 times/ week for 10 weeks. two-way anova for between-group comparisons and independent t-test for within-group comparisons were used in the statistical analysis.

a total of 45 patients (13 males and 32 females) participated in the current study. the participants were assigned to one of two groups in a random manner: an experimental group who received hippotherapy combined with schroth exercise and the control group who received only schorth exercise. (fvc, fev1, fev1/fvc, mvv, and 6mwt) were measured before and after 10 weeks intervention

Eligibility criteria:
inclusion criteria: * all types of curves, * curves between 10 and 20 degrees (29), * risser grade 0 to 5 * the availability to be engaged in once a week visit exclusion criteria: adolescents with: * obstructive pulmonary diseases * associated neuromuscular diseases * recent infectious episodes in the previous two months * history of cardiovascular or psychological disorders * any significant history of riding horses

Keywords: hippotherapy pulmonary function idiopathic scoliosis
taiwan health promotion intervention study for elders

Conditions: Frail Elderly Syndrome; Cognitive Impairment; Cognitive Decline

Summary: objectives: 1-year multidomain health promotion on prevention of physical and cognitive decline for community-living older people. design: methods: randomized controlled trial setting: five cities(taipei, taichung, kaohsiung, kinmen, i-lan) in taiwan participants: age 65 or older community-dwelling prefrail or frail adults intervention: 1-year multidomain health promotion (physical, cognitive, nutritional intervention) measurements: primary outcome includes frailty status and cognitive performance. secondary outcomes include depressive symptoms, nutrition assessment, and functional capacity; all the variables were measured at 0, 6, 12 months. the effect of intervention was investigated by intention-to-treat analysis.

eligibility criteria includes: community-dwelling older people aged 65 or older, and those with confirmed diagnosis of dementia or dependent on activities of daily living were excluded. primary outcome includes frailty status measured by chs frailty score. general and sub-domain cognitive performance measured by montreal cognitive assessment (moca). secondary outcomes include depressive symptoms, nutrition assessment, and functional capacity; which were evaluated by 5-item geriatric depression scale(gds-5), mini-nutrition assessment(mna), and instrumental activities of daily living (iadl) individually.

Eligibility criteria:
inclusion criteria: * prefrail or frail community-dwelling people exclusion criteria: * institutionalized or adl dependent * diagnosed dementia * limited life expectancy
immediate versus early invasive approach in non-st-elevation myocardial infarction (ideal nstemi)

Conditions: Non-ST-elevation Myocardial Infarction

Summary: of estimated 140,000 cases of acute myocardial infarction admitted to hospitals in germany per year, approximately 50% present with non-st-elevation myocardial infarction (nstemi). the currently available evidence led to current guideline recommendations that a systematic approach of immediate angiography in nstemi patients stabilized with contemporary antiplatelet treatment is not mandatory. however, this immediate invasive approach is appealing because it allows treating the underlying cause (the plaque rupture) as early as possible with subsequent reduction of death and recurrent myocardial infarction. in the ideal nstemi trial we test an immediate invasive approach (\<2 h) with an approach 12-72 h according top guidelines with respect to 6 months death and mortality.


Eligibility criteria:
inclusion criteria: * nstemi with * ischemic symptoms \>10 minutes within 24 h * elevated troponin or creatine kinase above the upper limit of normal * st-segment depression or transient st-segment elevation, t-wave inversion * informed consent. exclusion criteria: * age \< 18 years * age \> 90 years * persistent angina * hemodynamic instability * overt congestive heart failure * life-threatening arrhythmias * stemi * limited life-expectancy \< 6 months * chronic oral anticoagulation * fibrinolysis \< 48 hours * pci \< 14 days * contraindication for treatment with glycoprotein iib/iiia inhibitors, heparin, aspirin and clopidogrel * recent major trauma or surgery

Keywords: non-st-elevation myocardial infarction angiography percutaneous coronary intervention timing
short-term structured exercise training program plus diet intervention in patients with polycystic ovary syndrome (pcos)

Conditions: Polycystic Ovary Syndrome; Anovulation

Summary: clomiphene citrate (cc) is the first-line therapy for infertile women with polycystic ovary syndrome (pcos). unfortunately, at least 20% of pcos results are not responsive to cc. structured exercise training (set) and diet has been successfully employed to restore ovarian function and to improve reproductive outcomes in obese and overweight women with pcos. the current study was aimed to test the hypothesis that a short-term set program plus diet intervention can improve the ovarian response to cc in cc-resistant pcos patients.

ninety-six pcos patients considered cc-resistant because not responsive to 150 mg daily of cc were randomized in three arms (group a, b, and c). group a underwent set program plus hypocaloric diet for two months, group b had one month of observation followed by one-cycle of cc therapy, and group c underwent set program plus hypocaloric diet for two months and received one-cycle of cc for one cycle. cc was always given at the maximal dose previously used. clinical, hormonal and metabolic data were assessed at baseline and after intervention. ovulation was monitored by ultrasound and confirmed by plasma progesterone assay.

Eligibility criteria:
inclusion criteria: * pcos * anovulation exclusion criteria: * major medical condition * severe obesity

Keywords: clomiphene diet exercise infertility pcos physical activity treatment
dietary antioxidants and chronic diseases-the swedish national march cohort

Conditions: Myocardial Infarction; Diet; Osteoarthritis

Summary: dietary antioxidants might protect from the development of chronic diseases by reducing levels of oxidative stress. the investigators therefore investigated the effect of dietary non enzymatic antioxidant capacity, which measures interactions between antioxidants in the whole diet, on the risk of 1) myocardial infarction and 2) osteoarthritis.

aim: among an initial sample of 43,880 men and women who participated in the swedish national march cohort in 1997 the investigators aimed to investigate the effect of dietary non enzymatic antioxidant capacity (neac), assessed by a validated food frequency questionnaire at baseline, on the risk of 1) myocardial infarction and 2) osteoarthritis. identification of cases: incident cases of myocardial infarction (icd-10 code i21) and osteoarthritis (icd-10 m15-19) were identified through exact linkages to the swedish registries of population, migration, death, cancer, and inpatient care, using the national registration numbers as identifiers. main methods: the investigators fitted cox proportional hazards regression models with age as underlying time scale to estimate hazard ratios (hr) with 95% confidence intervals (95% ci) for each outcome of interest at different levels of dietary neac. the investigators fitted multiple imputation models based on chained equations to address missingness of confounder variables.

Eligibility criteria:
exclusion criteria study 1: * incorrect national registration number * subjects who were \<18 years * emigration before beginning of follow-up * death before beginning of follow-up * cancer diagnosis * any cardiovascular disease * extreme energy intake exclusion criteria study 2: * incorrect national registration number * subjects who were \<40 years * emigration before beginning of follow-up * death before beginning of follow-up * osteoarthritis diagnosis * bone cancer- or metastases * joint injury or any arthropathy disease other than osteoarthritis * extreme energy intake

Keywords: antioxidants oxidative stress atherosclerosis epidemiology
mitraclip® and hemodynamic effects of relevant iatrogenic atrial septum defect closure

Conditions: Mitral Valve Insufficiency; Heart Septal Defects, Atrial

Summary: aim of this prospective trial is to assess the hemodynamic effects of a mitraclip procedure caused iatrogenic arterial septal defect (iasd) and the functional changes after interventional iasd closure in a randomized setting.

transcatheter mitral valve repair with the mitraclip system is a therapeutic alternative to surgery in selected high-risk patients. clip placement requires interatrial transseptal puncture and meticulous manipulation of the steerable sheath. there is evidence that the persistence of a relevant iasd after mitraclip is associated with worse clinical outcomes and increased mortality. the purpose of this study is to investigate, if the interventional closure of an persistant hemodynamic relevant iasd 30 days after mitraclip implantation, has favorable effects on clinical outcome. eligible patients, after obtaining written informed consent, are 1:1 randomized either in group a (interventional occlusion of iasd) or group b (best supportive care).

Eligibility criteria:
inclusion criteria: * informed consent * previous mitraclip implantation * persistent relevant iasd 30 days after mitraclip intervention exclusion criteria: * unsuccessful mitraclip implantation * no relevant iasd 30 days after mitraclip intervention * unstable angina in the previous 4 weeks * valvular heart disease (aortic, tricuspid or pulmonary valve) planed for surgery or interventional therapy * constrictive pericarditis / restrictive cardiomyopathies * pericardial effusion planed for surgery or interventional therapy * coagulation disorders * malignant disease with a life expectance \< 12 months * pregnancy * participation in another study * iasd diameter \> 38 mm * aortic minimum distance of the iasd \< 5 mm * thrombus in left atrial appendage * venous access impossible with a 24 french catheter system * presence of an inferior vena cava filter
an observational study of ertapenem in outpatient parenteral antibiotic therapy (opat) for complicated urinary tract infections.

Conditions: Urinary Tract Infections

Summary: the aim of this study is to determine the outcomes when using ertapenem for complicated urinary tract infections in the opat setting. the study hypothesis: ertapenem is an efficacious and safe therapeutic option for complicated urinary tract infections in the opat setting.

enterobactericae spp. is a common cause of urinary tract infections. the prevalence of quinolone-resistance in enterobactericae is rising and often co-exists with expression of extended-spectrum beta-lactamases (esbl, limiting viable outpatient therapeutics options. in singapore, there is an increasing trend of treating patients who respond favourably to initial antimicrobial therapy in the outpatient setting (fisher, et.al, 2006). ertapenem is one of several agents with excellent antimicrobial activity against enterobactericae (including esbl producers). in view of its safety profile and its viability in elastromeric pump, it has great potential to be used in opat patients. there is no study analyzing outcomes in a large cohort of patients with complicated urinary tract infections treated with ertapenem.

Eligibility criteria:
inclusion criteria: * adult patients between 21 years old to 70 years old. * diagnosed with complicated urinary tract infection due to pathogen susceptible to ertapenem based on microbiology report, and the use of ertapenem is deemed clinically appropriate by the infectious disease physician in charge. exclusion criteria: * hypersensitivity reactions to ertapenem. * participation in another interventional clinical investigation within 30days * unable to obtain informed consent.

Keywords: ertapenem clinical outcome complicated urinary tract infections
potential biomarkers for early diagnosis of acute aortic dissection

Conditions: Aortic Dissection; Biomarkers and Early Diagnosis

Summary: acute aortic dissection (aad) is an acute vascular lesions with high early misdiagnosis rate(31.8%), and mortality rate was 38%. in recent years, the incidence is rising and serious threat to human health. at present, the clinical diagnosis of aad commonly used imaging methods, including chest x-ray, b ultrasound, ct, mri and aortic angiography. chest x-ray and two-dimensional ultrasound is limited in diagnosis of aad, esophageal ultrasonography can display the intimal, identify the true and false lumen, but greater risk. ct, mri and aortic angiography can be used as diagnosis method, but time-consuming, expensive and requires handling patients in emergency situations, should not be used as the preferred. therefore, it is significance that biomarkers with high specificity and sensitivity for clinical fast diagnosis of aad. parts small sample tests found that single serum α-smooth muscle actin (α-sma), myosin heavy chain(mhc) and human soluble elastin fragments (selaf) levels in patients with aad were significantly higher than that of others (normal people, acute myocardial infarction patients). but because of the small study sample, limited control risk factors and incomplete comparison, their conclusions were questionable. in our previous studies also found that serum α-sma, mhc and selaf levels and the pathogenesis of aad and prognosis are closely related. therefore, on the basis, a prospective study is needed. we observe all the three biomarkers in enrolled patients with acute chest pain in emergency department, levels in healthy volunteers as the blank control. then make definite diagnosis of the enrolled patients, and further observe the biomarkers dynamic change in aad. lastly, evaluate the early diagnostic value of combination serum α-sma, mhc and selaf level on patients with aad.

this is a prospective clinical study designed to procure blood samples from patients who present to the emergency department with suspected aad. subjects enrolled in this study will sign and informed consent and have 3 blood samples drawn at different time points during their emergency department visit. in addition, data will be collected about the patient's health history, hospital procedures, and final diagnosis. blood samples collected in this study will be sent to laboratory for long-term storage and analysis in the future for these blood markers as they become available. no genetic testing will be conducted on these samples.

Eligibility criteria:
inclusion criteria: * chest pain without diagnosis confirmed * symptom occurred in 2 hours * ≥18 years old * can complete the base information * able and willing to give written consent exclusion criteria: * known aad * known causes of acute chest pain such as tumour and trauma * pregnant or lactating female * associated chronic inflammatory diseases

Keywords: acute aortic dissection serum biomarkers early diagnosis
single session intervention to prevent common mental disorders and among college students

Conditions: Depression, Anxiety

Summary: the present study aims to determine the effect of presenting psychoeducation emphasizing "growth-mindset," and information on depression and anxiety symptom severity. the investigators hypothesize that psychoeducation emphasizing that mental health is malleable will increase the participant's engagement with risk factors outlined in the intervention

depression and anxiety disorders (or common mental disorders; cmds) are increasingly common among college students, with rates comparable to the general population. as such, brief, scalable and transdiagnostic prevention efforts targeting cmds are needed. in order to address this need, this study aims to evaluate the impact of a single session intervention (ssi) utilizing growth mindset (gm) on cmd symptom severity and investigate the mediating role of changes in modifiable risk factors in the relationship between intervention and cmd symptom reduction. the intervention will adapt existing gm interventions for college students to engage mechanisms in the prevention and management of common mental disorders including engagement in modifiable risk factors. college students will be randomly assigned to complete either a gm intervention or a psychoeducation control.

Eligibility criteria:
inclusion criteria: * age 17-26 * college student at the university of nevada, reno exclusion criteria: * under the age of 17, over the age of 26 * participated in pilot study * not a college student at the university of nevada, reno
intervention with a gaba supplement in prediabetics

Conditions: Prediabetes; Hypertension

Summary: in this double-blind parallel placebo controlled intervention study the effects of 3 times daily 500 mg gamma-aminobutyric acid (gaba) supplementation on glucose tolerance and cardiovascular health will be assessed in prediabetics.


Eligibility criteria:
inclusion criteria: * age between 50 and 70 * bmi higher or equal to 27 kg/m2 * impaired fasting glucose (fasting glucose ≥ 6.1 and ≤ 6.9 mmol/l) or/and * impaired glucose tolerance (glucose levels ≥ 7.8 and ≤ 11.1 mmol/l, 2-hours after an ogtt or/and glucose levels ≥8.6 mmol/l, 1-hour after an ogtt) exclusion criteria: * has been diagnosed with diabetes * having other conditions, like liver, pancreatic, cardiovascular, gastro-intestinal or endocrine diseases, that could influence the study results * use of medications or supplements that could influence the study results * sensitive to medical skin adhesives * more than 5kg weight change in the past 12 weeks * excessive alcohol consumption (\>21 glasses/week for men and \>14 glasses/week for women on average) * being an employee of wageningen university, division human nutrition and health * currently a research subject in other research