Kornimate/medical-research-clean huggingface dataset:
silodosin vs tamsulosin as met

Conditions: Stone, Urinary

Summary: the spontaneous passage rate for ureteral stone less than 1cm causing acute ureteral obstruction is about 50%. previous cochrane review has concluded that alpha blocker is likely to increase stone passage rate, reduce time to stone passage, analgesic use and hospitalisations. the european association of urology guideline also recommends giving alpha blockers as medical expulsive therapy to patients with distal ureteric stones \>5mm. however there is heterogeneity in different alpha blockers. silodosin is a recently introduced selective alpha blocker which has a much higher selectivity for the alpha-1-a receptor (17-fold compared with tamsulosin). from previous animal studies, ureteral contraction is mainly mediated by the alpha-1-a receptor, hence silodosin maybe more effective in increasing stone passage compared with tamsulosin. previous studies and meta-analysis has shown superiority of silodosin over tamsulosin on earlier stone passage and less pain. however, there is no data on chinese population. the investigators would like to compare the efficacy and side effect profile of silodosin versus tamsulosin on improving stone passage rate and hence reduce rate of further intervention for stone clearance.


Eligibility criteria:
inclusion criteria: * presented with radio-opaque ureteric stone of size 5mm to 10mm on kub * patients who can understand the study protocol and comply with the followup schedule exclusion criteria: * radiolucent stone * paper thin cortex * non-functioning kidney * renal insufficiency (serum creatinine greater than 1.8 mg/dl or 160umol/dl) * concurrent urosepsis * current \[alpha\]-blocker usage, ca channel blocker, steroid * pregnancy * age \< 18 * history of ureteral stricture * history of ureteric stone treatment within 2 years * allergic reaction to the study medication * unable to consent * patient on jj stent or pcn drainage
evaluation of the effectiveness of a nursing intervention program in reducing anxiety in users who perform scheduled sessions in the hyperbaric chamber

Conditions: Anxiety and Fear; Nurse's Role

Summary: the objective of this experimental study is to determine if the application of a nursing educational intervention reduces the anxiety of patients who are going to undergo treatment in the hyperbaric chamber. the researchers will compare the nursing educational intervention with the usual practice that is currently carried out in the unit for patients who are going to begin treatment in the hyperbaric chamber. participants will: * receive explanatory information through a camera triptych when the treatment is indicated. * come half an hour before the first session to receive a nursing educational intervention, with audiovisual support, on the operation of the camera.

the objective of this experimental study is to determine if the application of a nursing educational intervention reduces the anxiety of patients who are going to undergo treatment in the hyperbaric chamber. an educational intervention will be applied to the intervention group that will begin on the same day that the treatment is indicated. that day, you will be given an informative brochure about the most important aspects you should know about the hyperbaric chamber. on the first day of the session, you will be asked to come half an hour early to explain, in more detail, what the hyperbaric chamber consists of and important aspects that you should take into account. the control group will receive the same intervention that is currently being carried out. once treatment is prescribed in the chamber, they come on the first day and receive a brief explanation of how it works before entering.

Eligibility criteria:
inclusion criteria: * results in the pfeiffer questionnaire\<2. * that they understand spanish or catalan exclusion criteria: * that feel fear inside the hyperbaric chamber.

Keywords: anxiety nursing intervention hyperbaric chamber
acute high fat bulletproof coffee vs black coffee on metabolism, inflammation and cognitive function in healthy adults

Conditions: Leukocytosis; Triglycerides; Cognitive Function; Inflammatory Response

Summary: this study will determine whether acute ingestion of a high fat "bulletproof coffee" will lead to changes in plasma triglycerides, immune cell function, as well as cognitive function when compared to a black coffee.

in a randomized crossover design, participants will consume a single bulletproof coffee or a single black coffee separated by \~7 days. each visit commences in the morning after an overnight fast of 10-12 hours, with no exercise the day prior, no coffee consumption the morning of testing, and completion of a food log for dietary duplication prior to visit 2. a fasting blood draw is obtained and cognitive function tests administered, along with questionnaires to assess gastrointestinal distress, arousal, and hunger/fullness before coffee consumption. following this, one of the coffee beverages is consumed (randomized to each visit). cognitive testing and questionnaires are completed at 60 minutes after finishing the coffee, another blood draw at 90 minutes, and then cognitive testing, questionnaires and a final blood draw 180 minutes after consuming the coffee. this procedure is repeated during their second experimental visit, in which they consume the remaining coffee based on their randomization.

Eligibility criteria:
inclusion criteria: * must be over the age of 18 * must drink between 1-4 cups of coffee per day (on average) * must be able to tolerate lactose and dairy products * have not been sick for the past 3 weeks (immune function) * non smoker * must be able to fast for 10-12 hours exclusion criteria: * if you are required to take corticosteroids (immune function) * cannot understand or speak english * individual has an auto-immune disease and requires medication * individual is following a ketogenic diet * individual has allergy or sensitivity to dairy, coffee or caffeine or coconut oil * individual has hypertension

Keywords: triglycerides leukocyte monocyte neutrophil activation high-fat
human amniotic tissue-derived allograft, nucel, in posteriolateral lumbar fusions for degenerative disc disease

Conditions: Lumbar Degenerative Disc Disease; Spinal Stenosis; Spondylolisthesis; Spondylosis; Intervertebral Disk Displacement; Intervertebral Disk Degeneration; Spinal Diseases; Bone Diseases; Musculoskeletal Diseases; Spondylolysis

Summary: the purpose of this study is to compare the effect and safety of nucel to dbx on patients undergoing posteriolateral lumbar spinal fusions for degenerative disc disease.


Eligibility criteria:
inclusion criteria: * between the ages of 18 and 75 years * symptomatic, single-level degenerative lumbar disc disease, spondylosis or spondylolisthesis * failed conservative treatments * low risk for non-union * must be candidates for single-level, posteriolateral lumbar spine fusion * must be able and willing to give informed consent * english-speaking exclusion criteria: * smoker (any smoking ≤3 months prior to consent); (patel et al. 2013) * patients with poorly controlled diabetes mellitus (hgba1c \> 7%) * documented osteoporosis * prior lumbar spinal surgery at the same spinal level, or immediately adjacent spine level, to the level being operated on * back pain due to infection, tumour, or metabolic bone disease * terminal disease, such as hiv infection, neoplasm * autoimmune disease, such as rheumatoid arthritis * morbid obesity (body mass index (bmi) of 35 kg/m2) * major psychiatric illness in the last year * history of alcohol or drug abuse in the last year * pregnant women

Keywords: nucel lumbar spine degenerative disease efficacy fusion
an observational study of statin treatment induced hdl changes

Conditions: Cardiovascular Disease

Summary: the aim with this study is to investigate the effect of statin induced changes in hdl-c on all cause mortality and cvd with adjustment for changes in other blood lipids and clinical parameters in sweden, uk and the netherlands.

an observational study of statin treatment induced hdl changes - effect on cardiovascular disease

Eligibility criteria:
inclusion criteria: * started treatment with statins within the observation period (2004-2010) * the patient must have valid baseline and follow-up measurements for hdl-c and ldl-c. exclusion criteria: * malignancy alcohol abuse/alcohol dependence

Keywords: statin treatment cardiovascular disease statin treatment induced hdl changes and the effect on cardiovascular disease
the effect of reiki on anxiety, stress, and comfort

Conditions: Reiki; Gastro-Intestinal Disorder

Summary: upper gastrointestinal (gi) endoscopy is a procedure that is used in the examination, diagnosis, and treatment of the esophagus, stomach, and duodenum. with developments in present-day technology, it is safe and widely used. this study's aim is to determine the effect of reiki when applied before upper gastrointestinal endoscopy on levels of anxiety, stress, and comfort. this single-blind, randomized, sham-controlled study was held between february and july 2021.

anxiety and stress are problems that are often seen in patients undergoing upper gi endoscopy, and managing them is an important step in calming the patient and thereby reducing complications.the results of this study will contribute to the literature in forming a basis for other studies on the topic. the aim of this study is to evaluate the effects of the application of reiki and sham reiki on anxiety, stress, and comfort levels in patients undergoing upper gi endoscopy.

Eligibility criteria:
inclusion criteria * patients who were having an upper gi endoscopy for the first time, * patients who were age 18 or over, * patients who had not previously had reiki or sham reiki (sr), * patients who did not have a history of an operation in the previous six months, * patients who were not using anxiolytic, hypnotic, or sedative drugs, * patients who had no cognitive or effective problems or any hindrance in communication, * patients who was literate, and who agreed to take part in the study. exclusion criteria * patients who had an upper gi endoscopy with more than one elective condition, * patients who was undergoing an emergency upper gi endoscopy, * patients who were using anxiolytic, hypnotic, or sedative drugs, * patients who had taken an opioid analgesic before the procedure, * patients who completed the data collection forms incorrectly or incompletely, * patients who had previously had reiki or sr, * patients who had a runny nose, fever, cough or any complaint of breathing difficulty, * patients who were not literate and who did not wish to voluntarily participate.
effect of a dietary supplement on quality of life

Conditions: Quality of Life

Summary: the purpose of this research study is to evaluate the effect of a combination of 3 food components to improve the quality of life in people who have trouble sleeping. ten subjects with insomnia will drink 2 ounces of the supplement or a placebo for 1 week and after a 2 weeks washout period, will take the treatment they did not take the first week. questionnaires to evaluate quality of life, and a sleep study will be done before and after each treatment week.

each participant will be in the study for about 1 month. the questionnaires consist of chubon quality of life rating, the multi-dimensional fatigue inventory, insomnia severity index, the epworth sleepiness, pittsburgh sleep quality index. subjects will be screened with a medical questionnaire, vital signs, height, weight, oximetry to identify sleep apnea, a cbc and chemistry panel and the insomnia severity index. weight, vital signs, adverse event questioning, dispensing and collection of test material will be done at each visit. during each treatment week subjects will wear an actigraph, keep a sleep diary and at the beginning and end of each treatment week subjects will have a polysomnography. at the end of each treatment period subjects will have a chemistry panel, a cbc, and a buffy coat will be archived.

Eligibility criteria:
inclusion criteria: * healthy men or women \>50 years of age * usual bedtime between 9pm and midnight * insomnia for \>6months by icsd-2 criteria * insomnia severity index score \>10 and sleep-onset latency or waking after sleep onset \>30 minutes exclusion criteria: * have diabetes mellitus * taking chronic medication not on a stable dose for \>1month * taking sedating or hypnotic medications * have a sleep disorder other than insomnia (like sleep apnea) adults unable to consent prisoners pregnant women individuals not yet adults
nobio antimicrobial particles effect in a split mouth model

Conditions: Cervical Caries

Summary: the study purpose is to evaluate the antimicrobial effect of nobio particles incorporated within novidia dental bonding and flowable composite versus standard of care within a split mouth model.the study population will include 35 subjects considered to be at high risk for cervical caries and affected by uncontrolled plaque accumulation

an exploratory, comparative, self-controlled single blinded interventional study. intended to evaluate the antimicrobial effect of nobio particles incorporated within novidia dental bonding and flowable composite versus filtek bond and flow composite within a split mouth model.the study population (n=35) will be high risk population for cervical caries (with at least 2 carious cavities in the mouth) affected by uncontrolled plaque accumulation.each subject will serve in this model as his own control.on one side the novidia intervention will be made and on the contralateral side the filtek intervention.

Eligibility criteria:
inclusion criteria: * male or female over 18 years of age. * requires two cervical restorations or the exchange of existing ones * subject has poor oral hygiene and at high risk for plaque accumulation. * subject able and willing to comply with study visits and follow up visits and signed the informed consent. exclusion criteria: * allergic reaction to iodide. * pregnant or lactating women. * use of antiseptic mouth rinse or antibiotic up to 2 weeks before the beginning of study. exclusion criteria for the chosen teeth for the study: * tooth designated for extraction in the following 6 month. * tooth designated to have a root canal treatment. * tooth or several teeth designated for periodontal surgery.
safety and effectiveness of cyclosporin in the management of covid19 ards patients in alexandria university hospital

Conditions: COVID-19 Acute Respiratory Distress Syndrome; Cytokine Release Syndrome; Pulmonary Fibrosis

Summary: the study to evaluate the effect of cyclosporine ( il2 inhibitor and antiviral) verse standard care treatment on decrease adrs, hyper inflammation, hypercytokinemia, and the mortality rate

to test the efficacy of il-2 inhibitors (cyclosporine) compared to the standard of care according to hospital protocol on covid-19 patients concerning the clinical outcome (cytokines level, clinical improvement, and pcr of sars-cov-2 through the study period). aim: the slow progression of the disease, improving survival among covid-19 patients, and standard assessment of patient improvement. * standard assessment of patient improvement: * pcr-sars-cov-2 negative * no fever * no cytopenia (hb ≥90 g/l, anc ≥0.5x109/l, platelets ≥100x109/l) • * no hyperferritinemia ≥500 μg/l * (decrease of il2)

Eligibility criteria:
inclusion criteria: 1. current infection with covid-19 2. written informed consent 3. confirmed diagnosis of covid-19 by pcr (polymerase chain reaction) tests and/or positive serology or any existing and validated diagnostic covid-19 parameters during this time. 4. 18yrs ≥ age \<66 yrs 5. chest x-ray showing suggestive of covid-19 disease. 6. both gender 7. the presence of pulmonary fibrosis or hyper inflammation signs or a syndrome of cytokine release defined as any of the following:: 1. leukopenia or lymphopenia, 2. ferritin \> 500ng/ml or d-dimers ≥ 500 ng/ml 3. hs\>90 exclusion criteria: 1. lactation and pregnancy women 2. unlikely to survive beyond 48h 3. need for mechanical ventilation. 4. cases of multiorgan failure or abnormal renal function and shock. 5. malignancies, autoimmune disease, perforation of the bowels or diverticulitis. 6. active bacterial or fungal infection. 7. we define impairment of cardiac function as poorly controlled heart diseases, cardiac insufficiency, unstable angina pectoris, myocardial infarction within 1 year before enrollment, supraventricular or ventricular arrhythmia needs treatment or intervention, uncontrolled hypertension (\>180/110 mmhg. 8. levels of serum transaminase \>5 upper references rang 9. symptoms of active tuberculosis or human immunodeficiency virus (hiv) positivity 10. the patient receiving vaccines: live, attenuated vaccines 11. subjects received monoclonal antibodies within one week before admission. 12. patients receiving high-dose systemic steroids (\> 20 mg methylprednisolone or equivalent), immunosuppressant or immunomodulatory drugs 13. contraindications for use in people with psoriasis include concomitant treatment with methotrexate, other immunosuppressant agents, coal tar, or radiation therapy. -

Keywords: covid-19 cyclosporine secondary haemophagocytic lymphohistiocytosis (shlh) acute respiratory distress syndrome (ards)
ibuprofen versus ketorolac for perioperative pain control after open hysterectomy

Conditions: Postoperative Pain; Hysterectomy

Summary: the aim of this study is to compare the analgesic effect of intravenous ibuprofen to ketorolac for pain control after open hysterectomy

thirty minutes before the surgery, all patients will receive 1 gm paracetamol intravenously then every 6 hours postoperatively. a research assistant is responsible for opening the envelopes, group assignment and drug preparation (the three doses will be prepared and marked with the patient's name as well as the time of administration) without any further involvement in the study. the patient, attending anesthetist, nurse and data collector will be blinded to the administered drug. upon arrival to the operating room, routine monitors (electrocardiogram, pulse oximetry, and non-invasive blood pressure monitor) will be applied; intravenous line will be secured, and prophylactic antiemetic will be provided in the form of slow intravenous injection of 8 mg dexamethasone drugs. anesthesia anesthesia will be induced with 2 mg/kg propofol, 1 mcg/kg fentanyl, and tracheal intubation will be facilitated by 0.5 mg/kg atracurium after loss of consciousness. anesthesia will be maintained with isoflurane 1-1.2% in oxygen and 0.1 mg/kg atracurium every 20 minutes. intraoperative analgesia will be in the form of 1 mcg/kg fentanyl boluses as needed. postoperatively, pain assessments using the visual analogue scale (vas) will be performed at rest and during movement (knee flexion) at 0.5, 2, 4, 6, 10, 18, and 24 h after leaving the operating room. if the vas score is \> 3 intravenous titration of 2 mg morphine given slowly to be repeated after 30 minutes if pain persisted. intravenous ondansetron 4 mg will be given to treat postoperative nausea or vomiting

Eligibility criteria:
inclusion criteria: * adult (40-65 years) * asa i-ii women * scheduled to undergo open elective abdominal hysterectomy with or without salpingo-oophorectomy exclusion criteria: * renal impairment, * allergy to any of study's drugs, * history of gastrointestinal bleeding or ulceration, or inflammatory bowel disease, * severe cardiac comorbidity (impaired contractility with ejection fraction \< 50%, heart block, significant arrhythmias, tight valvular lesions), * patients undergoing surgery for suspected gynaecological cancer, * patients on chronic analgesic medication, * inability to comprehend the visual analogue pain scoring scale
effects of glucose fluctuation intervention on the prognosis of patients with type 2 diabetes and cerebral infarction

Conditions: Type 2 Diabetes and Cerebral Infarction

Summary: the present randomized control trial sought to establish glucose fluctuation as an important target for management on metabolic index, neurologic function, and quality of life in type 2 diabetes mellitus (t2dm) patients and cerebral infarction (ci).

there is a significant association between glycemic ﬂuctuation and the incidence of diabetes macrovascular complications. therefore, understanding the impact of glycemic fluctuations on diabetic macroangiopathy could be helpful for discovering a strategy of prevention and treatment of macroangiopathy in diabetes. however, previous studies on the glycemic fluctuation in t2dm patients with ci were cross-sectional studies, there has been no prospective intervention study confirming the effects of glucose fluctuation targeted management on the prognosis of t2dm patients following ci. based on previous fingdings, investigators will assess the effects of glucose fluctuation targeted intervention on metabolic index, neurologic function, and quality of life in t2dm patients and ci.

Eligibility criteria:
inclusion criteria: * 1. cerebral infarction within one month, diagnosed by magnetic resonance imaging (mri) or computed tomography (ct) according to 1995 acute cerebral infarction diagnosis standards promulgated by the fourth national cerebrovascular disease conference \[1\]; * 2. having type 2 diabetes mellitus (as defined by the who diagnostic criteria in 1999) \[2\]; exclusion criteria: * 1. coexisting acute complications of diabetes including diabetic ketoacidosis (dka), hyperglycemic hyperosmolar syndrome (hhs), metabolic acidosis; * 2. severe comorbid chronic complications of diabetes; * 3. active malignancy; * 4. subjects with mental illness and communication disorders; 5) those actively participating in other research studies.

Keywords: type 2 diabetes cerebral infarction glucose fluctuation targeted intervention
perineal trauma after jet ski accidents and long-term functional outcomes results

Conditions: Perineum; Tear, Traumatic; Anal Tear; Anal Incontinence

Summary: french multicentric retrospective cohort study including patients who underwent an ano-perineal trauma following a personal watercraft/jet-ski accident and that were treated in france from january 2017 to december 2023. aims of the study were to describe the initial management of the patients and to evaluate the digestive, urological and sexual functional outcomes as well as the quality of life, using validated questionnaires commonly employed in clinical practice.

ano-perineal injuries and their mechanisms resulting from personal watercraft (pwc)/jet-ski accidents are poorly understood and may lead to long-term functional repercussions, previously unmentioned in studies. these accidents are in france but, mostly, concerned young women, back-seated on the pwc without any specific protection. therefore, the research team conducted a french multicentric cohort study that retrospectively included patients who experienced ano-perineal trauma following a personal watercraft/jet-ski accident and were treated in france. data on pre-hospital management, pre-operative work-up, surgical management (including surgical techniques), short-term and long-term complications (routinely used functional scores) were collected through the analysis of personal medical records. several patients had sphincteric, rectal, vaginal, or combined injuries, sometimes requiring the establishment of a stoma. the investigators subsequently evaluated the rate of fecal incontinence (evaluated by anorectal manometry or wexner score), urological (usp score), and sexual outcomes (fsfi). quality of life was also assessed using the sf12 score.

Eligibility criteria:
inclusion criteria: * ano-perineal trauma following a pwc/jet-ski accident between january 2017 and december 2023 * managed and followed in france exclusion criteria: * \<18 years old

Keywords: ano-perineal trauma ano-perineal injury personal watercraft jet-ski functional outcomes peripheral neurogenic bladder fecal incontinence