Kornimate/medical-research-clean huggingface dataset:
rock steady boxing: a community based in person class

Conditions: Parkinson Disease

Summary: the purpose of this study is to evaluate the feasibility and effectiveness of a non-contact rock steady boxing class delivered to participants with parkinson's disease via an in-person community-based program. the study will also assess the overall feasibility of integrating an in-person community program within a neuromuscular course in a doctor of physical therapy program. specific aim: to examine the effects of an in-person community-based rock steady boxing class on the functional mobility, functional endurance, cardiovascular capacity, visual-motor reaction times, quality of life, mood/affect and overall physical activity completion and fear of falling on individuals with parkinson's disease.

participants will be recruited directly from the the brain center (non-for-profit neurology clinic). participants will be educated on the study but advised that their participation is voluntary and researchers will not coerce boxers to participate in the study. once a participant agrees to participate, the informed consent will be completed. during this time, participants will be told their participation is voluntary and they can quit at any time. he primary interventions being assessed in this study include the in-person rock steady boxing class offered at usahs once per week. prior to attending the rock steady boxing classes, all participants must be provided with medical clearance from a referring medical doctor. the rock steady boxing classes are 60-90 minutes in duration and include the following 4 components: (1) active warm up (2) functional mobility exercises (3) whole body strengthening exercises and (4) non-contact boxing exercises. during the classes, boxers' vitals are assessed using health rate monitors.

Eligibility criteria:
inclusion criteria: 1. male or female 2. age range: 18 years or older 3. history of parkinson's disease between hoehn and yarh stages i and iv 4. medical clearance from a referring medical doctor 5. able to complete all assessments 6. willing to complete a weekly exercise log exclusion criteria: 1. unable to complete the assessments. 2. pregnant or is expected to become pregnant during study 3. other reasons that may limit participation in exercises. -
staccato loxapine multidose pk

Conditions: Volunteers on Chronic, Stable Antipsychotic Regimens

Summary: the objectives of this trial are to assess the safety, tolerability, and pharmacokinetics of multiple inhaled doses of staccato loxapine.

the purpose of the present phase 1 study in schizophrenic patients is to assess the safety and pharmacokinetics of multiple doses of staccato loxapine given within a 24 hour time period. the study will be conducted in schizophrenic patients who are on chronic, stable antipsychotic medication. patients meeting entry criteria will be randomized to one of three dose sequences of staccato loxapine or to staccato placebo. following administration of medications, safety, tolerability and pharmacokinetic assessments will be conducted at serial time points.

Eligibility criteria:
inclusion criteria include: 1. male and female subjects between the ages of 18 to 65 years, inclusive. 2. subjects who are on stable, oral, chronic (\>2 mos) antipsychotic medication regimen and who are able to tolerate the rapid oral dose taper and substitution regimen. exclusion criteria include: 1. subjects who are currently treated with injectable depot neuroleptics within one dose interval must be excluded. 2. subjects who have received loxapine or amoxapine within the last 30 days must be excluded. 3. subjects with a history of allergy or intolerance to dibenzoxazepines (loxapine and amoxapine) must be excluded. 4. subjects with a history of movement disorders including parkinson's disease or a history of neuroleptic malignant syndrome must be excluded. 5. subjects who have a history within the past year of drug or alcohol dependence or abuse as defined by dsm-4 must be excluded.

Keywords: pharmacokinetic multidose staccato loxapine
functional assessment of adl in patients who underwent bifocal and trifocal presbyopic correction

Conditions: Presbyopia

Summary: patients who underwent bilateral bifocal or trifocal lenses implantation for presbyopia correction with monofocal intraocular lenses implantation are supposed to have sufficient uncorrected vision capacity for activities of daily living (adls) that require: a) distant vision (dv), (ie. driving), b) intermediate vision (iv), (ie. computer word processing), c) near vision (nv), (ie. book reading). primary objective of the study is the comparison in a series of adls of two cohorts of patients (group 1: subjects with bilateral bifocal lenses implantation, group 2: subjects with bilateral trifocal lenses implantation)


Eligibility criteria:
inclusion criteria: * presbyopic patients that underwent either bilateral bifocal or trifocal intraocular lenses implantation exclusion criteria: * glaucoma, corneal pathology, fundus pathology, mental or neurological disorder
vitamin a to reduce hiv in vaginal secretions and prevent viral transmission

Conditions: HIV Infections; Vitamin A Deficiency; HIV Seronegativity

Summary: hiv infected individuals with vitamin a deficiency may be more likely to transmit the virus to others than hiv infected individuals who have normal levels of vitamin a. the presence of hiv dna in vaginal secretions may indicate a greater risk for transmission of hiv to others. the purpose of this study is to determine if taking vitamin a decreases the level of hiv dna in vaginal secretions.

vitamin a deficiency leads to pathological changes in mucosal epithelium, including the vagina, and is correlated with immune dysfunction in both hiv-1 infected and uninfected individuals. recent studies of genital tract shedding of hiv-1 dna in infected women have found that lower serum concentrations of vitamin a were strongly associated with detection of hiv-1 in vaginal secretions. in addition, maternal vitamin a deficiency has been associated with significantly increased risk of vertical hiv-1 transmission. this study will assess the effect of vitamin a supplementation on the prevalence and quantity of hiv-1 dna and rna in cervical and vaginal secretions. participants in this study will be hiv infected nonpregnant women in mombasa, kenya. participants will be randomized to receive 6 weeks of daily dosage of either 10,000 iu vitamin a or placebo. cervical and vaginal swabs will be obtained at enrollment and at week 6 for detection and quantification of hiv-1 dna and rna. in addition, venous blood will be obtained at the two time points for quantification of plasma hiv-1 rna, cd4 lymphocyte count, and serum vitamin a levels.

Eligibility criteria:
inclusion criteria: * hiv infected exlusion criteria: * pregnant

Keywords: hiv-1 women vitamin a shedding
rehabilitation, quality of life, and exercise tolerance in patients with an icd

Conditions: Heart Patients After ICD Implantation

Summary: relax-icd trial/research study; quality of life/protocol no.p-kare-01: a 3-month outpatient rehabilitation therapy and psychological counselling including informative talks with conventional therapy, by a cardiologist or general practitioner after implantation of an internal cardioverter defibrillator (icd) in adult patients, whereby the effects of three different strategies are compared. study hypothesis: the rehabilitation programme will be beneficial in the management of any psychological problems possibly as a result from the intervention, and will help to overcome anxiety, and contribute to improved quality of life.

university hospital inselspital berne,switzerland: site nr. 1 - jean-paul schmid, md, ... recruiting / virga jesseziekenhuis,hasselt, belgium: site no. 2 - paul dendale,md,.... recruiting / medical university of gdansk, poland, site no. 3 - dominika zielinska,phd,.... recruiting / cliniques universitaires saint luc, brussel, belgium: site no. 4 - christian brohet,md prof.... recruiting / state hospital for cardiology, balantonfüred, hungary: site no. 5 - gabor veress, md prof, ...recruiting

Eligibility criteria:
inclusion criteria: * first icd implant within past 12 weeks * agrees to sign patient/partner informed consent exclusion criteria: * angina pectoris ccs iii \& iv * nyha functional class iv * inability to follow rehabilitation programme * exercise limitations due to clinical condition * symptomatic exercise-induced tachyarrhythmias * any major non-cardiac condition that would adversely affect survival during study duration * unable to comply to study procedures * participates in a concurrent study

Keywords: icd distress anxiety quality-of-life
elongation of foveal tissue after macular hole surgery

Conditions: Macular Holes

Summary: in our experience, elongation of foveal tissue after macular hole surgery which was undetectable by conventional time-domain optical coherence tomography was often observed on spectral-domain optical coherence tomography images. elongation of tissues inevitably induces some degree of disorganization of tissue microstructure. the purpose of the present study was to evaluate elongation profile of foveal tissue after macular hole surgery and to investigate its impact on visual acuity and metamorphopsia.


Eligibility criteria:
inclusion criteria: * patients who were diagnosed with idiopathic macular hole exclusion criteria: * traumatic macular hole * evidence of ocular inflammation, diabetic retinopathy, hypertensive retinopathy, and retinal vasculitis, media opacity that would influence visual acuity or preclude acquisition of clear spectral domain optical coherence tomography images * presence of cataract judged to affect visual function, -6.0 diopters or more of spherical equivalent, prominent staphyloma * history of intraocular surgery other than uncomplicated cataract surgery, other ocular diseases that may influence the macular microstructure or visual function * patients with indistinct intraretinal structure on spectral domain optical coherence tomography images

Keywords: macular holes spectral domain optical coherence tomography elongation of foveal tissue m-score
conventional versus individual extralvator abdominoperineal excision for advanced lower rectal cancer

Conditions: Rectal Cancer

Summary: an alternative treatment for low rectal cancer is the extralevator abdominoperineal excision (elape) technique. we aim to compare the outcomes of patients undergoing conventional elape versus individual elape.

we suppose that the elape technique may be performed according to individual conditions. for the rectal tumors suitable for elape, most of them were circular or nearly circular infiltrating tumors. patients with these rectal tumors should receive full elape resection. in those rectal tumors not involving the levator ani muscle, the dissection plane may continue close to the external anal sphincter and the levator ani muscle, leaving the ischioanal fat and the terminal branches of the pudendal nerve intact.if the tumor has only penetrated into 1 side of the levator ani muscle, the dissection might include the levator ani muscle and the fat of the ischioanal fossa on the side of the tumor to achieve a clear circumferential resection margin, whereas the ischioanal fat and levator ani muscle on the other side of the tumor may be left . this individual elape may be as effective as conventional elape while minimizing the operative trauma and the damage to the nerves of the genital organs.

Eligibility criteria:
inclusion criteria: * tumor within 5 cm of the anal verge or with a very narrow pelvis * t3-t4 as determined by preoperative magnetic resonance imaging or endorectal ultrasonography examination or a low tumor is fixed or tethered at rectal examination * absence of distant metastases * absence of intestinal obstruction exclusion criteria: * t1-t2 as determined by preoperative magnetic resonance imaging or endorectal ultrasonography examination * with distant metastases * with intestinal obstruction * pregnancy or lactation * allergic constitution to heterogeneous protein * with operation contraindication

Keywords: advanced lower rectal cancer extralevator abdominoperineal excision circumferential resection margin morbidity survival
prognostic value of stress spect myocardial perfusion imaging with half dose 99mtc-tetrofosmin

Conditions: Cardiovascular Disease

Summary: the purpose of this study is to evaluate the quality and prognostic ability of low dose 99mtc-tetrofosmin myocardial perfusion spect imaging.

the objective of this study is to determine if myocardial perfusion imaging (mpi) using a new spect reconstruction software and a low dose (ld) of 99mtc-tetrofosmin will provide equal quality and prognostic value as a full dose (fd) of 99mtc-tetrofosmin myocardial perfusion spect imaging methodology. the images of clinical patients from the diagnostic imaging department will be assessed and compared for image quality and myocardial perfusion. the outcomes of participants that have had fd studies will be compared to those who have had ld studies. consented participants will be contacted and will be asked to provide information on their cardiovascular health since the date of their ld or fd scan, such as non fatal myocardial infarction, death, congestive heart failure, admission to hospital with chest pain, further cardiac diagnostic testing, including angiography and early and late revascularization. the event information will be tabulated at 6, 12, 18, and 24 months for the ld and fd studies. the study hypothesizes that there will be no difference in the quality and prognostic value between the ld and fd 99mtc-tetrofosmin spect mpi imaging protocols. the study hypothesizes that there will be no increase in repeat diagnostic testing and angiography with using the ld imaging protocol.

Eligibility criteria:
inclusion criteria: * participants who have completed the fd and ld mpi studies on the ge infinia haweye or ge nm 530 (czt crystal) cameras * retrospective participants must consent to the study interview(s) for data collection * prospective participants must consent to follow up for data collection exclusion criteria: * unwilling to consent to data collection either retrospectively or in follow up prospectively

Keywords: 99mtc-tetrofosmin myocardial perfusion imaging spect radiation
yoga in adult cancer: a feasibility trial

Conditions: Quality of Life

Summary: a feasibility study to determine the appropriateness of yoga intervention to improve health-related quality of life in adult cancer patients.

a prospective, mixed methods feasibility trial allocated participants to receive one of three yoga interventions over a four-week study period. data collection was completed through online survey of qol-ca/cs and customized surveys.

Eligibility criteria:
inclusion criteria: 1. male and female adult cancer patients 19 years of age or older 2. patients receiving or planning to receive conventional treatment that includes at least one of chemotherapy, radiotherapy, hormone therapy or active surveillance within 28 days 3. patients in any stage of cancer diagnoses of all tumour types and locations 4. participants with internet access and willingness to participate in online communication 5. participants with access to transportation and personal willingness to attend meetings in central vancouver, canada. 6. participants fluent in the english language exclusion criteria: 1. patients with any physical limitation, risk of personal injury or under proscription of light to moderate physical activity 2. patients with pre or post surgical interventions were excluded due to potential physical limitations or safety concerns with wound healing 3. regular or experienced practitioners of yoga were excluded and defined as those patients reporting current or historical use of regular yoga (\>2 session per month in past 12 months) 4. patients undergoing medical treatment for serious psychological disturbances that might have interfered with adherence to protocol and/or ability to provide informed consent were excluded (e.g. multiple personality disorders, severe depression, obsessive-compulsive disorder)
a study of an automated insulin delivery system in adult participants with type 1 diabetes mellitus

Conditions: Type 1 Diabetes Mellitus

Summary: the purpose of this study is to evaluate whether an automated insulin delivery (aid) system is safe to use and functions as intended with personalized basal insulin rates and when basal insulin rates are increased.


Eligibility criteria:
inclusion criteria: * participants with t1dm for at least 2 years and who have used an insulin delivery system with any rapid-acting insulin analog for the preceding 6 months * have a body mass index of 18.5 to 37 kilogram per meter squared * have a hemoglobin a1c level ≥6.0% and ≤9.0% exclusion criteria: * have known allergies or history of hypersensitivity to insulin lispro * have had an episode of severe hypoglycemia within the past 6 months * have had more than 1 episode of diabetic ketoacidosis in the past 6 months
measures to increase the effectiveness of fast track colorectal clinics for iron deficiency anaemia.

Conditions: Colorectal Cancer

Summary: a retrospective cohort study was conducted from 2016-18 in a single busy district general hospital providing services to a population of 700,000 people. in the study, patients with true ida (low mcv and ferritin) were found to be more likely to have colorectal cancer compared to any other type of anaemia which confirmed the latest guidelines for management of ida. compared to symptoms, only the presence of a mass on abdominal examination and rectal examination was found to be more likely associated with cancer.

although there are strict and specific guidelines for referring patients with iron deficiency anaemia (ida) to fast track colorectal cancer (ft crc) clinics for further assessment and investigation, patients with other types of anaemia are still referred by primary care physicians in the uk. investigators aim was to find out whether this practice is correct, or if it is causing an overburden on colorectal clinics and endoscopy services. investigators also want to find out whether true/absolute ida has a higher predictive value for diagnosing colorectal cancer (crc) compared to other types of anaemia and specific bowel symptoms. investigator's hypothesis was that patients with ida are more likely to have crc compared to patients with no anaemia or non-ida anaemia. by confirming this hypothesis, investigators can identify high risk patients from the population who can then be preferentially subjected to investigations mandated by guidelines. this strategy can help to increase the diagnostic yield of ft crc clinics. a retrospective cohort study was conducted from 2016-18 in a single busy district general hospital providing services to a population of 700,000 people. in the study, patients with true ida (low mcv and ferritin) were found to be more likely to have crc compared to any other type of anaemia which confirmed the latest guidelines for management of ida. compared to symptoms, only the presence of a mass on abdominal examination and rectal examination was found to be more likely associated with cancer. physicians should be able to stratify patients based on blood indices when referring them to ft crc clinics. diagnostic yield of these clinics can be increased if clinicians strictly adhere to fast track guidelines and confirm true ida before referring patients to clinic.

Eligibility criteria:
inclusion criteria: - patients with age more than 18 years presenting to fast track colorectal clinic 1. with bowel symptoms 2. presenting with anaemia 3. rectal bleeding exclusion criteria: * any patient presenting through routine colorectal clinics 1. with bowel symptoms 2. presenting with anaemia 3. rectal bleeding aged less than 18 years

Keywords: anaemia colorectal cancer iron deficiency anaemia
pk and pd profile of dance 501 in healthy, non-diabetic subjects with mild to moderate asthma or copd

Conditions: Safety and Tolerability

Summary: this will be a randomized, open-label, active-controlled, single dose crossover study with either three or four treatment periods. investigational treatment is with dance 501 human insulin inhalation solution (dance 501) and the comparator is insulin lispro (humalog®). target population will be non-diabetic individuals with mild to moderate asthma or chronic obstructive pulmonary disease (copd) and non-diabetic individuals without underlying lung disease (healthy subjects).

the pk and pd profile of dance 501 (human insulin inhalation solution and inhaler) will be compared to subcutaneous injection of insulin lispro.

Eligibility criteria:
inclusion criteria: * non-diabetic subjects with asthma, or copd. non-smokers or smokers quit at least 6 months prior to enrollment. bmi \<= 35 kg/m2. fasting blood glucose \<= 125 mg/dl. exclusion criteria: * pulmonary disorder other than asthma or copd. upper respiratory within previous 4 weeks. significant exacerbation of asthma or copd symptoms. hospitalization for asthma or copd within previous 3 months. clinically significant medical condition. current medications interfering with glucose metabolism.

Keywords: inhaled insulin asthma copd
promoting physical activity in people with schizophrenia.

Conditions: Schizophrenia

Summary: people with schizophrenia die approximately 20 years earlier than those in the general population, and this is mostly due to cardiovascular disease (cvd) and related poor physical health. the risk factors for cvd are significantly more prevalent in people with schizophrenia, but they are largely preventable by, for example, engaging in regular pa. existing interventions to increase pa in schizophrenia are generally atheoretical and lack manualisation and appropriate evaluation, thus reducing their usefulness to clinical practice. drawing on the mrc guidelines for the development and evaluation of complex interventions, a 12-week intervention was developed and informed by a systematic review of the factors that influence pa in people with schizophrenia and a qualitative study exploring the barriers and motivators to pa (n=10). the feasibility and acceptability of the intervention was then investigated in an uncontrolled pilot study (n=20). the pilot study demonstrated that the intervention was both feasible and acceptable to people with schizophrenia. the retention rate was 90% (n=18), and reasons given for dropout were work commitments and other illness. of the 18 who completed the intervention, 17 (94%) increased their weekly step count, 14 (78%) met current public health guidelines of 10,000 steps per day at some point during the 12 weeks, 10 (56%) experienced some weight loss, 12 (67%) took up an additional health promotion opportunity (e.g., improving diet, stopping smoking, joining a gym) and 13 (72%) took up another form of pa in addition to walking (e.g., swimming). participants found the intervention enjoyable and thought it should be offered to everyone with schizophrenia. the intervention also proved to be feasible and acceptable to staff who referred patients to take part. informal feedback from staff confirmed the need for such a service, particularly for those taking anti-psychotic medication, and indicated that, if it was to be implemented more widely, it would be a popular and useful resource.


Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia or related disorder (e.g., schizoaffective disorder, psychosis) * living in the community * clinically stable for at least 8 weeks prior to intervention enrolment * ability to safely walk unaided exclusion criteria: * inability to provide informed consent

Keywords: physical activity intervention walking