Kornimate/medical-research-clean huggingface dataset:
oblique subcostal tap block efficacy in laparoscopic cholecystectomy

Conditions: Pain

Summary: laparoscopic cholecystectomy although a minimally invasive procedure, may be accompanied by considerable pain after surgery. more recently transversus abdominis plane (tap) block was extensively studied as a potential analgesic maneuver after laparoscopic cholecystectomy. the subcostal approach (ostap block) is a variation on the tap block that produces reliable supraumbilical analgesia.

laparoscopic cholecystectomy is a minimally invasive widespread surgical procedure, with postoperative lower pain scores and quick recovery of the patient. however some of patients may complain of considerable pain after surgery . there are several approaches to postoperative pain management after laparoscopic cholecystectomy such as patient-controlled analgesia with opioids (iv-pca), neuraxial blocks, intraperitoneal injection of local anesthetics, wound infiltration, each being more or less effective, with specific side effects. the transversus abdominis plane block (tap-block) is a regional analgesia technique that comes as an alternative to "classical" procedures of postoperative analgesia. described by rafi and mcdonnell et al. this technique has undergone some changes over times, which increased its efficiency. thus, hebbard et al. described ultrasound subcostal oblique approach (ostap) of the block allowing analgesia in both the upper and lower abdomen, with a lower rate of complications due to the direct ultrasound visualization. different studies confirmed the analgesic efficacy of this technique and the postoperative opioid sparing effect after laparoscopic cholecystectomy . traditionally, the transversus abdominis plane block is achieved with classical amino-amides local anesthetics, bupivacaine, levobupivacaine and ropivacaine being the most commonly used . based on the local anesthetic properties of pethidine, a synthetic opioid, our study aimed to evaluate prospectively the analgesic efficacy of pethidine in achieving transversus abdominis plane block by ultrasound oblique subcostal approach in patients scheduled for elective laparoscopic cholecystectomy.

Eligibility criteria:
inclusion criteria: * american society of anaesthesiologists (asa) i-ii * age over 18years old * patients scheduled elective laparoscopic cholecystectomy exclusion criteria: * open cholecystectomy - excluded due to increased levels of pain in open procedures * renal dysfunction (serum cr \> 1.2) - excluded due to potential altered metabolism of anesthetic and pain medications * coagulopathy or anticoagulation - increased risk of bleeding from nerve block injection * allergy or contraindication to any of the study medications or anesthetic agents * chronic opioid analgesic use at home - excluded due to potential difficulty in assessing pain caused by the procedure alone * patient inability to properly describe postoperative pain to investigators (language barrier, dementia, delirium, psychiatric disorder) * pregnancy * prisoners * patient or surgeon refusal

Keywords: pethidine laparoscopic cholecystectomy bupivacaine
prospective cohort study for varicose veins incidence and natural course

Conditions: Varicose Veins of Lower Limb; Thromboses, Venous; Venous Insufficiency

Summary: a prospective study of individuals without varicose veins and who have primary varicose veins to assess the morbidity, risk factors and natural course of chronic lower limb vein disease.

multicenter prospective cohort observational study based on a termless epidemiological registry. periodic inspection and collection of data from the subjects is carried out annually, in the last quarter of the current year. patient data is recorded in a digital database and is constantly updated

Eligibility criteria:
inclusion criteria: * a family members of the researcher (spouse, childrens, brothers and sisters, parents) or the researcher himself * the possibility of annual clinical and ultrasound assessment of the venous system of the observed individuals exclusion criteria: * any invasive treatment of the chronic venous disorder in anamnesis * venous thrombosis in the anamnesis or at the time of inclusion
pao2/fio2*peep (p/fp) ratio and mortality in acute respiratory distress syndrome.

Conditions: Adult Respiratory Distress Syndrome

Summary: the pao2/fio2 (p/f) ratio is same for all the positive end expiratory pressure (peep) ≥ to 5. this p/f ratio misleads the severity of disease without the knowledge of set peep. the oxygenation status is actually worse when the patient is using high peep. p/f ratio doesn't include peep in the calculation.the p/f ratio doesn't show the severity of the disease appropriate for the set peep. pao2/(fio2 x peep) p/fp ratio is a new formula which addresses this gap to appropriately calculate the severity of the disease by including peep in the formula. this formula is used to predict mortality for different severities of ards.

the main aim of this study is to analyse whether this formula can early diagnose the severity of the disease appropriate for the set peep, so the rescue measure can be started early which can eventually decreases the mortality. increasing the peep value with the same fio2 gives a different pao2 and spo2. the oxygenation improves substantially by increasing only the peep. so including the peep in calculating the severity of oxygenation is better than the current practice. the current definition of ards for oxygenation is p/f ratio of 300 to 200 is mild, 200 to 100 is moderate and less than 100 is severe ards with peep ≥ 5. the new p/fp ratio of 300 to 200 is mild, 200 to 100 is moderate and less than 100 is severe adult respiratory distress syndrome (ards) for all the different levels of peep values.

Eligibility criteria:
inclusion criteria: intubated patients for * adult respiratory distress syndrome * stroke * seizures * post neurosurgery * endoscopy procedure * post cardiac collapse exclusion criteria non intubated patients on * room air * nasal cannula * face mask * venturi mask * non rebreathing mask

Keywords: p/fp ratio ards definition severity of oxygenation in ards
insight - post marketing surveillance

Conditions: Carcinoma, Hepatocellular

Summary: in this international non-interventional post-marketing surveillance study we want to evaluate patient characteristics in hcc patients as well as efficacy and safety of sorafenib (nexavar®) treatment under daily-life treatment conditions. specifically investigated are the tumor status, prior and/ or concomitant surgical, radiological and drug treatment and the duration of sorafenib treatment.


Eligibility criteria:
inclusion criteria: * in- and outpatients with diagnosis of hepatocellular carcinoma (hcc) and decision taken by the investigator to prescribe nexavar exclusion criteria: * exclusion criteria must be read in conjunction with the local product information

Keywords: carcinoma, hepatocellular sorafenib
patient experiences and the role of team structures in pulmonary rehabilitation in türkiye

Conditions: Pulmonary Disease; Pulmonary Rehabilitation

Summary: the pretty study aims to evaluate patient satisfaction with pulmonary rehabilitation (pr) services across türkiye and to investigate how satisfaction levels are related to the organizational structures and team compositions of the pr programs. this national, multicenter, cross-sectional observational study will also identify structural and organizational factors that may enhance patient-centered care and promote the standardization of pr services.


Eligibility criteria:
patient inclusion criteria: * age ≥18 years * diagnosed with a respiratory condition (e.g., copd, interstitial lung disease, asthma, bronchiectasis, etc.) * completed a structured pr program (minimum duration and frequency as defined by national guidelines or center-specific protocols) * willing and able to complete the online patient satisfaction questionnaire * able to provide informed consent patient exclusion criteria: * ongoing participation in a pr program (only completed cases will be included) * inability to complete the questionnaire due to cognitive or language barriers without a caregiver coordinator inclusion criteria: * officially designated as the pr program coordinator or responsible team member * affiliated with a healthcare institution (public, university-affiliated, or private) in türkiye that provides pr services * willing to complete the institutional survey form regarding team structure, service delivery, and organizational characteristics * authorized by the institution to provide structural data related to the pr unit coordinator exclusion criteria: * pr services provided on an informal or ad-hoc basis without a designated team or structure * institutions not offering a structured pr program
pharmacokinetics, safety and tolerability of ago178c in subjects with renal deficiencies compared with healthy subjects

Conditions: Renal Impairment

Summary: this study will assess the pharmacokinetics, safety and tolerability of a single dose of ago178c in subjects with mild, moderate, severe renal impairment and end-stage renal disease with that in healthy matched control subjects.


Eligibility criteria:
inclusion criteria: * mild, moderate, severe renally impaired or esrd patients. * healthy male or female subjects to match renally impaired patients in bmi (±15%), age (± 7 years) and gender (in this order). smoking status (yes or no) will also be used as a final criterion, if deemed feasible by the investigator. exclusion criteria: * pregnant or nursing (lactating) women * women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless using effective contraception during the study as defined in the protocol. * smokers, smoking 10 cigarettes or more per day from screening to study completion * any surgical or medical condition which might significantly alter the absorption, distribution, metabolism, or excretion of drugs, or which may jeopardize the subject in case of participation in the study * co-medication for healthy subjects other protocol-defined inclusion/exclusion criteria may apply

Keywords: ago178c, renal impairment, esrd, pharmacokinetics
digital patient support program for self-efficacy and medication adherence in women on adjuvant endocrine treatment for breast cancer

Conditions: Breast Cancer; Cancer

Summary: this is a randomized, controlled study to assess the effect of sidekick health's digital program on self-efficacy and medication adherence in breast cancer patients prescribed adjuvant anti-hormonal treatment. participants will be treated with the digital program in addition to standard of care (soc), or soc only.

sidekick health has developed a digital patient support tool delivered via mobile application (app), to support people who have been diagnosed with breast cancer with self-efficacy in managing their symptoms and with medication adherence and holistic lifestyle modification. the sidekick platform includes a medication center, including behavioral change material and tools aimed at improving adherence. the study will be a 2-arm, parallel-group, randomized (1:1) controlled trial to evaluate the performance of sidekick's digital patient support program for patients with breast cancer on patients' self-efficacy and medication adherence in women undergoing adjuvant endocrine treatment. 140 participants will be included, and eligible participants will be randomized to receive the sidekick digital support program plus standard of care, or standard of care only.

Eligibility criteria:
inclusion criteria: * adult patient (18 years or older) diagnosed with breast cancer of stage i, ii or iii from 1st september 2023 or later * have been prescribed adjuvant endocrine therapy for breast cancer. * understands written and spoken icelandic or english. * owns a smart-phone compatible with the sidekick app and capable to use it * willing to download the sidekick app on the smart-phone and to comply with the study measures and visits according to the protocol. * capable of providing informed consent for participating in the study. exclusion criteria: * having other concurrent conditions that in the opinion of the oncologist may compromise patient safety or study objectives. * concurrent participation in another clinical study in which the study treatment may confound the evaluation of the investigational program. * metastatic breast cancer (stage iv) * previous experience with sidekick breast cancer program

Keywords: cancer breast cancer medication adherence self-efficacy lifestyle change endocrine treatment digital health application
is there hearing loss after acute mastoiditis

Conditions: Acute Mastoiditis; Acute Otitis Media

Summary: following acute mastoiditis there is a possible risk to develop hearing loss. the cause could be either possible involvement of the inner ear, or in cases that underwent surgery, secondary to the effect of the drill's noise. extended hearing test will be performed for 25 children that suffered acute mastoiditis that resolved with conservative treatment and compared with 25 children that needed surgical intervention.


Eligibility criteria:
inclusion criteria: * history of acute mastoiditis 4 years and older exclusion criteria: * younger than 4 years old not cooperative for hearing test active ear disease major medical illness

Keywords: acute mastoiditis hearing loss mastoidectomy audiogram
nt-probnp versus clinical guided discharge in acute heart failure

Conditions: Heart Failure

Summary: our objective is to compare a policy of hospital discharge guided by nt-probnp levels versus discharge guided by conventional clinical criteria, in patients admitted with acute heart failure. the hypothesis is that the nt-probnp guided discharge will shorten hospital stay without worsening the outcome

nt-probnp levels as well as their response to pharmacological treatment are predictive of prognosis in patients with heart failure. the purpose of the present project is to investigate, in patients hospitalized with acute heart failure, whether a discharge decision guided by nt-probnp response shortens hospital stay and improves prognosis the included patients will be randomly assigned to one of these two strategies: hospital discharge according to clinical conventional criteria or discharge guided by nt-probnp. all patients will be treated following clinical guidelines. in the guided nt-probnp strategy, patients will be discharged the third day if nt-probnp levels drops \>30% compared to admission values. if such a reduction is not achieved, then the pharmacological treatment will be increased and nt-probnp will be measured the following days until reaching the 30% reduction. in the conventional strategy, patients will be discharged at criterion of the attending cardiologist according to clinical assessment without nt-probnp. the main outcome will be the number of days of hospitalization at the index episode, and the secondary outcome will be death or readmission by heart failure at one and 6 months. our hypothesis is that the nt-probnp guided discharge will allow to precisely evaluate the response to treatment and to determine the best time for hospital discharge. this will reduce hospital stay and death or readmission rate after discharge.

Eligibility criteria:
inclusion criteria: 1. clinical signs and symptoms of acute heart failure, according to the criteria of the european guidelines 2. nt-probnp levels \> 1000 pg/ml at the time of admission 3. age over 18 years old 4. signed informed consent exclusion criteria: 1. gfr less than 30 ml/minute/m2, 2. life expectancy as determined by concomitant diseases under one year, 3. acute coronary syndrome within 10 days prior, 4. valvular heart disease with surgical approach, 5. infection or process active malignancy, 6. chronic respiratory failure with pulmonary disease.

Keywords: heart failure nt-probnp
comparison of scar results and time for closures of scalp defects via pulley sutures or layered repairs

Conditions: Scar

Summary: surgical defects on the scalp require closure via various techniques of suture placement. a traditional technique requires both dermal (deep) and epidermal (superficial) placement of sutures to close the defect; this is referred to as intermediate or complex linear repair. however, the scalp is a location with high tension, and thus the closures take an hour or longer to perform. a type of suture placement referred to as the "pulley stitch" requires placement of a few stitches along the defect. the pulley stitch can be used in areas of high tension to close a large defect. the purpose of this study is to compare the scar results and time taken to perform scalp closures via only pulley stitches or via intermediate/complex linear repairs. to my knowledge, no such study has been performed to compare the two techniques. such a study would be useful in demonstrating comparable scar appearance and reduce the time to perform scalp closures.


Eligibility criteria:
inclusion criteria: 1. age greater than 18 years 2. ability to understand risks, benefits, and alternatives to the study and to be able to give an informed consent 3. lesions such as skin cancer or benign lesions on the scalp amenable to surgical excision or to mohs surgical technique 4. frontal scalp defects defined as frontal hair line to crown of scalp 5. scalp defect size of 2cm - 8 cm exclusion criteria: 1. patients who tend to form keloids or hypertrophic scars 2. patients with a history of scleroderma or morphea 3. pregnant or breast-feeding females 4. patients whose surgical defects require flap closures

Keywords: pulley scalp defects
exploring the utility of [18f]3f4ap for demyelination imaging in controls, neurodegeneration and traumatic brian injury

Conditions: Brain Injuries, Traumatic; Demyelinating Disorder; Alzheimer Disease

Summary: the overall objective is to obtain an initial assessment of the value of using \[18f\]3f4ap for imaging demyelinating diseases such as traumatic brain injury (tbi), neurodegenerative diseases such as mild cognitive impairment (mci) and alzheimer's disease (ad): * aim 1) assess the safety of \[18f\]3f4ap in healthy volunteers and subjects with traumatic brain injury (tbi) and neurocognitive impaired subjects (ad/mci). hypothesis 1: administration of \[18f\]3f4ap will result in no changes in vitals or other adverse events. * aim 2) assess the radiation doses to the main organs in healthy volunteers. hypothesis 2: the radiation doses to each organ will be comparable in all subjects and within the acceptable limits. * aim 3) assess the pharmacokinetics of a bolus infusion of \[18f\]3f4ap in humans including healthy volunteers and patients. hypothesis 3: the pharmacokinetics of \[18f\]3f4ap at the whole brain level will be similar in controls, tbi and ad/mci subjects. the kinetics in demyelinated lesions will be slower than in healthy areas. * aim 4) correlate mr images with \[18f\]3f4ap pet images. hypothesis 4a: all the lesions seen on the mri will show increased signal (vt or suv) on the pet images. hypothesis 4b: some of the lesions on the mri will show increased signal (vt or suv) on the pet but not all. * aim 5) correlate \[18f\]3f4ap pet signal with neuropsychological testing in people with tbi and ad/mci. hypothesis 5a: increased pet signal (vt or suv) will correlate with impaired mini mental state examination (mmse).


Eligibility criteria:
inclusion criteria: * subjects are 18 years of age and older, except ad subjects who are 60 to 90 years of age. exclusion criteria: * a subject will not be eligible for inclusion in this study if any of the exclusion criteria for pet/ct or mri studies applies. a negative stat quantitative serum hcg pregnancy test is required on the day of the pet/ct scan before female subjects of childbearing potential can participate. any woman of childbearing potential, who is seeking to become pregnant, is breastfeeding, or who suspects she may be pregnant will not be enrolled in the study.

Keywords: 3f4ap
symptoms experienced and quality of life in breast cancer receiving radiotherapy

Conditions: Quality of Life

Summary: eortc-qlq-30 questionnaire filled in by participants 6 times

eortc-qlq-30 questionnaire filled in by participants 6 times * 1st before receive radiotherapy * 2nd after receive radiotherapy * 3th 1 month after receive radiotherapy * 4th 3 month after receive radiotherapy * 5th 6 month after receive radiotherapy * 6th 1 year after receive radiotherapy

Eligibility criteria:
inclusion criteria: * good consciousness * ability to understand and provide information * no hearing impairment * eastern cooperative oncology group performance level of 0 to 2 exclusion criteria: * prior radiotherapy
carotid ultrasound study

Conditions: Resistant Hypertension

Summary: to use carotid ultrasound to screen 20-30 patients with longstanding or resistant hypertension for carotid atherosclerotic disease and bifurcation anatomy. this will establish a screening protocol for cibiem's eventual endovascular carotid body modulation trial and will give insight into the prevalence and specific location of carotid plaque at the bifurcation in this patient population.


Eligibility criteria:
inclusion criteria: * 18-75 years old * uncontrolled hypertension on 3 or more medications or longstanding controlled hypertension on 4 or more medications. exclusion criteria: * previous stroke * carotid endarterectomy or carotid stent procedure * \>50% stenosis anywhere in carotid arteries
real-world of ai in diagnosing retinal diseases

Conditions: Artificial Intelligence; Retinal Diseases

Summary: the objective of this study is to apply an artificial intelligence algorithm to diagnose multi-retinal diseases in real-world settings. the effectiveness and accuracy of this algorithm are evaluated by sensitivity, specificity, positive predictive value, negative predictive value, and area under curve.

the objective of this study is to apply an artificial intelligence algorithm to diagnose referral diabetes retinopathy, referral age-related macular degeneration, referral possible glaucoma, pathological myopia, retinal vein occlusion, macular hole, macular epiretinal membrane, hypertensive retinopathy, myelinated fibers, retinitis pigmentosa and other retinal lesions from fundus photography. tic 45-degree fundus cameras, trained operators took binocular fundus photography on participants. operators were then asked to identify gradable images and unload for algorithm diagnosis. the effectiveness and accuracy of this algorithm are evaluated by sensitivity, specificity, positive predictive value, negative predictive value, area under curve, and f1 score.

Eligibility criteria:
inclusion criteria: * fundus photography around 45° field which covers optic disc and macula * complete identification information exclusion criteria: * insufficient information for diagnosis