Kornimate/medical-research-clean huggingface dataset:
efficacy of two bolus doses of remifentanil on the incidence of coughing during emergence of anesthesia

Conditions: Cough; Anesthesia

Summary: this study is designed to compare the effects of two bolus doses of intravenous remifentanil given prior to the emergence of anesthesia: * on the incidence of perioperative coughing * on the time needed for the emergence of a desflurane-based anesthesia * on the incidence of sore throat after extubation. the investigators hypothesis is that the use of a higher remifentanil bolus dose (0.5 mcg/kg) given prior to emergence of a desflurane-based anesthesia will reduce the incidence of perioperative coughing when compared to a lower dose of remifentanil (0.25 mcg/kg).

emergence is an important period of general anesthesia during which several problems can occur. coughing, hypertension, tachycardia and agitation have been observed during emergence of general anesthesia. most patients will cough during emergence. different techniques and drugs have been studied to reduce coughing during emergence. there is some evidence supporting the administration of intravenous opioids prior to emergence of general anesthesia to reduce perioperative coughing, agitation and haemodynamic stimulation. however, depending on the type of opioids given, this may delay the emergence from anesthesia. the effect of a remifentanil infusion given in combination with isoflurane as the volatile agent has been shown to reduce the incidence of perioperative coughing without delaying the emergence of anesthesia. the effect of a small bolus of remifentanil given prior to emergence to prevent perioperative coughing has yet to be studied. desflurane is a newer volatile agent allowing early recovery from anesthesia. this agent has led to earlier discharge and more rapid resumption of normal activities after surgery. however, an incidence of coughing around 70% has been reported after a desflurane-based anesthesia. this study will compare the effects of two bolus doses of remifentanil (0.25 mcg/kg to 0.5 mcg/kg) when given prior to emergence to prevent perioperative coughing after a desflurane-based anesthesia.

Eligibility criteria:
inclusion criteria: * patients aged 18-80 years * physical status 1-3 * patients undergoing elective surgery under general anesthesia requiring endotracheal intubation (excluding head and neck surgery) exclusion criteria: * current use of ace inhibitors * chronic cough * asthma or severe pulmonary disease * pulmonary tract infection * anticipated difficult intubation * current use of opioids * current use of cough medicine * contraindication to remifentanil * pregnancy * symptomatic cardiac, renal or hepatic disease
a phase 2, to evaluating the safety and efficacy of pridopidine vs placebo for symptomatic treatment in patients with huntington's disease

Conditions: Huntington's Disease

Summary: this is a multicenter, multinational, randomized, parallel-group, double-blind, placebo-controlled, dose range finding study to compare the efficacy and safety of different doses of pridopidine versus placebo in the treatment of motor impairment in huntington's disease (hd).

originally, the study was designed to assess the effect of pridopidine on motor function at 26 weeks. due to the recognition that the primary target of pridopidine is the sigma-1 receptor, the trial was extended from 26 to 52 weeks to evaluate the effect of pridopidine on total functional capacity (tfc). a minimum of 52 weeks are needed for the placebo group to decline and allow a window to assess an effect on tfc (a prespecified endpoint). approximately 20% of patients completed 26 weeks of the study before irb approvals for this extension, and did not continue into the 2nd treatment period up to 52 weeks.

Eligibility criteria:
inclusion criteria: * diagnosis of hd based on the presence of \>/= 36 cag repeats * male or female age ≥21 years, with an onset of hd after 18 years' old. * females of childbearing potential must be compliant in using adequate birth control throughout the duration of the study * body weight ≥50 kg * sum of \>= 25 points on the uhdrs-tms and uhdrs independence score \<=90% * able and willing to provide written informed consent prior to any study related procedure. * willing to provide a blood sample for genetic analyses * willing and able to take oral medication and able to comply with the study specific procedures. * ambulatory, being able to travel to the study center, and judged by the investigator as likely to be able to continue to travel for the duration of the study. * availability and willingness of a caregiver, informant or family member to accompany the patient to the clinic at study, and the suitability of the caregiver should be judged by the investigator. * other criteria apply, please contact the investigator for more information. exclusion criteria: * patients with clinically significant heart disease at the screening visit * treatment with tetrabenazine within 6 weeks of study screening * patients with a history of epilepsy or of seizures within the last 5 years * have other serious medical illnesses in the opinion of the investigator may put the patient at risk when participating in the study or may influence the results of the study or affect the patient's ability to take part in the study * patients receiving medications (within the last 6 weeks prior to screening) that have been proven to prolong qt interval or who may require such medications during the course of the study such as but not limited to non allowed anti psychotic medications, tricyclic antidepressants and/or class i antiarrhythmics * other criteria apply, please contact the investigator for more information

Keywords: huntington's disease pridopidine pride-hd
adapted physical activity in patients with resected pancreatic cancer (apacapop prodige-56 study): a national multicenter randomized controlled phase ii trial

Conditions: Pancreas Cancer; Quality of Life

Summary: exercise during chemotherapy (ct) is a promising strategy to reduce fatigue and improve health-related quality of life (hrqol). exercise may also have beneficial effects on tumor outcome by decreasing insulin resistance, inflammation, and by modulating various pro-tumoral signalling pathways. it has been shown to reduce mortality in breast and colorectal cancer adjuvant setting. this study aims to explore the effects of adapted physical activity (apa) in patients with resected pancreatic ductal adenocarcinoma (pdac).


Eligibility criteria:
inclusion criteria: * histologically proven pdac * complete macroscopic resection (r0 or r1 resection) * patients randomized within 12 weeks of surgery * no evidence of malignant ascites, liver metastasis, spread to other distant abdominal organs, peritoneal metastasis, spread to extra-abdominal organs * sufficient recovery from the operation and fit to take part in the trial * able to attend for administration of the adjuvant ct * ecog ps 0-2 * age ≥ 18 years * life expectancy \> 3 months * dated and signed informed consent * registration in a national health care system (cmu included). exclusion criteria: * macroscopically remaining tumor (r2 resection or tnm stage iv disease) * histology other than pdac * cardiovascular, respiratory, psychiatric, musculoskeletal, or neurological condition contra-indicating exercise practice * pregnancy or breastfeeding * protected adults (individuals under guardianship by court order). note: participation to another concomitant clinical trial is allowed but the patient must inform and get an authorization from the investigator.
ultrasound-guided deep versus superficial continuous serratus anterior plane block for pain management in patients with multiple rib fractures

Conditions: Multiple Rib Fractures; Pain, Acute; Serratus Anterior Plane Block

Summary: the present clinical study will be undertaken to evaluate the effect of ultrasound-guided deep versus superficial continuous serratus anterior plane block for pain management in patients with multiple rib fractures.

thoracic blunt trauma, especially when multiple rib fractures are associated, is challenging to manage and causes significant morbidity due to the severe pain implied. patients can present with respiratory compromise as their capacity to expand the thorax is limited by pain. as a result, they are at high risk to develop atelectasis and pneumonia. the key goal of management is adequate analgesia and pulmonary volume expansion various strategies to treat such pain have been utilized, including regional analgesia (intrapleural, intercostal paravertebral nerve blockade), and neuraxial analgesia (thoracic epidural analgesia (tea), intrathecal opioids). the use of neuraxial analgesia in polytrauma is frequently limited by the need for aggressive venous thromboembolic (vte) prophylaxis, and positioning of the patient for a neuraxial approach may be impossible. there is a growing interest in exploring treatments that are less invasive than ea and can be performed on patients who have contraindications to neuraxial analgesia. ultrasound-guided serratus anterior plane (sap) block is a recent technique, first described by blanco et al. in 2013, that provides analgesia for the thoracic wall by blocking the lateral branches of the intercostal nerves from t2 to l2. it is a safe, simple to perform block with no significant contraindications or side effects. he described 2 potential spaces, one superficial and another deep to serratus. the sapb has been used effectively for the management of pain in the context of rib fractures, thoracoscopic surgery, thoracotomy, breast surgery, and post-mastectomy pain syndrome, few studies compared the two approaches, and the difference between them has not yet been studied in patients with multiple rib fractures.

Eligibility criteria:
inclusion criteria: * adult patients of either sex, having three or more unilateral fracture ribs and admitted to the trauma icu, rib fractures were confirmed by x-ray and ct scan reads. exclusion criteria: * significant head injury and unconsciousness (gcs less than 14) * patients with significant pain from other injuries * pathological obesity (body mass index ≥35) * history of drug allergy local anesthetics * local infection at the injection site * inability to obtain consent from patient or surrogate, and patient refusal

Keywords: serratus anterior plane block multiple rib fractures
lipid-lowering therapy for secondary prevention in patients undergoing elective percutaneous coronary intervention (pci)

Conditions: Coronary Artery Disease

Summary: the purpose of the study is to follow the management of blood lipids in patients with planned percutaneous coronary intervention (widening of coronary vessels) in a period from 6 to 10 weeks after the intervention.


Eligibility criteria:
inclusion criteria: * male or nonpregnant female * coronary patient hospitalised for elective pci * hypercholesterolaemia defined as ldl-c ≥ 2 mmol/l exclusion criteria: * any chronic inflammatory condition * chronic anti-inflammatory pharmacotherapy (except low-dose asa)

Keywords: blood lipids percutaneous coronary intervention lipid lowering treatment
a long-term study in patients with amyotrophic lateral sclerosis (als)

Conditions: Amyotrophic Lateral Sclerosis (ALS)

Summary: the purpose of this study is to investigate the safety and efficacy of long-term e0302 administration in patients with amyotrophic lateral sclerosis (als).


Eligibility criteria:
inclusion criteria: 1. patients who have completed phase ii/iii study of e0302 (e0302-j081-761, hereafter referred to as study 761) except for those patients who discontinued the treatment of study 761. completed patients are defined as those who completed the treatment period of study 761, those on 24-hour use of non-invasive positive pressure ventilation (nippv), or those who eventually resulted in the use of nippv. 2. patients who are able to submit written informed consent. if patients are duly capable of study consent but are unable to sign (or affix a seal) by themselves due to aggravation of disease condition, written informed consent can be obtained from a legally authorized representative who can sign on behalf of the patients after confirming the patients' agreement to study participation. exclusion criteria: 1. patients with cognitive impairment. 2. pregnant women or women who may have a possibility of becoming pregnant. 3. patients or their partners who are not willing to use reliable contraception. 4. patients with severe disease in the renal, cardiovascular, hematological, or hepatic system (severe disease will be judged referring to "ministry of health, labor and welfare (mhlw) drug safety dept. notification no. 80, drug safety classification criteria for severity of adverse drug reaction by medicinal products, grade 3." however, an event due to the primary disease will be precluded). 5. patients with malignant tumor. 6. patients who participated in another clinical study after the completion of study 761. 7. patients with present illness or history of drug allergy or severe allergic disease (anaphylactic shock). 8. patients who are judged to be ineligible for study entry by the investigator or subinvestigator.

Keywords: amyotrophic lateral sclerosis motor neurons muscular atrophy
evaluation of different diagnostic methods of tuberculosis in assiut university hospitals

Conditions: Tuberculosis Diagnosis

Summary: * detection of sensitivity and specificity of microscopic examination and molecular studies using polymerase chain reaction (pcr) mycobacterium tuberculosis (mtb)/ non tuberculous mycobacterium (ntm) mdr-tb compared to culture which is the gold standard technique in the diagnosis of tb to reach the most reliable one for better health care service. * assess the prevalence of tuberculosis cases among clinically suspected cases admitted to the hospital throughout the selected study period.

tuberculosis (tb) is an infectious disease of global public health importance caused by the m. tuberculosis complex. alarmingly, the disease has worsened with the emergence of multidrug-resistant strains of tuberculosis (mdr-tb). annually, it is estimated that approximately 450,000 new cases of mdr-tb occur according to a report from 2021. there is an alarming increase in the global incidence rate of tuberculosis in the year 2021 after covid-19 pandemic, reversing the downward trend maintained in previous decades. in parallel, there is a rise in cases of drug-resistant tuberculosis. early diagnosis and appropriate treatment of tuberculosis are essential public health priorities. in this context, microbiology laboratories play a vital role in the rapid and accurate detection of tuberculosis and drug resistance. accurate and prompt diagnosis of tb is essential for the control and management of the disease, but there are numerous factors that affect the effectiveness of this process. these problems include the difficulty of correctly diagnosing latent and active forms of tb, the lack of precise protocols for different types of tb, and the difficulty of accessing diagnostic facilities in regions with limited resources. laboratory diagnosis of pulmonary tuberculosis is essential in combating the disease, with a significant role in patient management and isolation of contagious cases. in many developing countries with a high incidence of tb, advanced diagnostic methods and drug susceptibility testing are rarely available. given its substantial influence on global health, it is imperative that the investigators continue researching and developing innovative techniques and technologies to better the detection and treatment of tuberculosis. in our study, the investigators try to compare between different available tests to diagnose tb for better treatment and health care service.

Eligibility criteria:
inclusion criteria: * patients with signs and symptoms of tuberculosis (suspected cases) * patients diagnosed with tuberculosis. exclusion criteria: * patients with pulmonary infections other than tb
lymphocyte enhancement in gastroenteric oncology

Conditions: Advanced Gastrointestinal Cancers

Summary: lego is single center double-blind randomized trial aimed at testing the efficacy of an essential ammino acid (eaa) supplementation in improving the absolute count of peripheral lymphocytes and the tolerance to chemotherapy in patients with advanced gastrointestinal malignancies not candidates to immune check-point inhibitors containing regimens.

the aim of the study is to verify that, in lymphopenic patients, aae supplementation leads to an increase in lymphocytes circulating in the blood. in particular, at the end of treatment, in patients with lymphocytes \< 29.7% of the total number of white blood cells, we want to observe the disappearance of lymphopenia.

Eligibility criteria:
inclusion criteria: * diagnosis of epithelial neoplasia of the gastrointestinal tract in advanced stage with indication for first-line chemotherapy for palliative purposes and with circulating lymphocytes \< 29.7% of the number total white blood cells in the blood. * ecog ps ≤ 2 * start of first-line palliative chemotherapy agreement with aiom guidelines. * adequate nutritional counseling carried out before starting of the treatment * willing to participate by providing written informed consent exclusion criteria: * age \< 18 years * current or indicated artificial nutrition * gluten intolerance * prediction of use of granulocyte growth factors * confirmed diagnosis of copd, chronic heart failure, insufficiency chronic kidney disease, chronic liver failure, collagen disease, diseases endocrine, insulin-dependent diabetes, malignancy in other locations. all these conditions are associated with documented alterations in the plasma profile of amino acids and potentially of subsets of circulating t lymphocytes.
systemic redesign and demonstration for early detection, evaluation and management of chronic kidney disease in shanghai

Conditions: Chronic Kidney Diseases

Summary: based on clinical evidence based medicine and organizational management model, investigators redesign the prevention and treatment of chronic kidney disease of public health system in shanghai china. the investigators hope to find early chronic kidney disease, prevention and clinical intervention of orderly combination. the advantages of this system were confirmed by comparing the prevalence rate, awareness rate and treatment rate before and after the completion of the system.

the whole study mainly includes the following parts: 1. establishment of a database of patients with kidney disease, and training data entry specialist in every center. 2. conduct propaganda of kidney disease knowledge, training professional doctors in center hospital and community hospital. 3. search for high-risk patients, and screening for patients with kidney disease from community residents in community hospital. 4. establishment of a standardized and orderly patient referral process from community hospital to center hospital or three level of first-class hospital.

Eligibility criteria:
inclusion criteria: * over 18 years of age. * signed informed consent exclusion criteria: * refused to accept the blood and urine test
a single-arm study evaluating the effectiveness and safety of suzetrigine (suz) for acute pain after aesthetic or reconstructive surgeries

Conditions: Acute Pain

Summary: the purpose of this study to evaluate the effectiveness, safety, and tolerability of suz as part of multimodal therapy (mmt) in treating acute postoperative pain.


Eligibility criteria:
key inclusion criteria: * body mass index (bmi) of greater than or equal to (≥)18.0 to less than or equal to (≤) 40.0 kilogram per meter square (kg/m\^2) * participants scheduled to undergo an aesthetic or reconstructive surgical procedure that would typically be treated with opioid therapy for at least 72 hours postoperatively key exclusion criteria: • participated in a previous study with suz or received journavx other protocol defined inclusion/exclusion criteria may apply.
the effect of dexmedetomidine on the emergence agitation in nasal surgery

Conditions: Airway Extubation

Summary: the investigators examined the effect of dexmedetomidine on the emergence agitation and postoperative quality of recovery in nasal surgery

emergence agitation during the immediate postanesthetic period is common. it may lead to serious consequences for the patient, such as injury, increased pain, hemorrhage, self-extubation, and removal of catheters. emergence agitation is common in ent surgery. the aim of this study is to evaluate the effect of dexmedetomidine on the emergence agitation and postoperative quality of recovery in adult patients undergoing nasal surgery.

Eligibility criteria:
inclusion criteria: * age ≥ 20, * asa class i and ii, * nasal surgery exclusion criteria: * bradycardia (\< 45 bpm), * heart block, * liver failure, * renal failure, * uncontrolled hypertension, * body mass index ≥ 30 kg/m2
functional outcome after arthroplasty

Conditions: Fracture Neck of Femur

Summary: bipolar hemiarthroplasty (ba) has long been the preferred treatment and is performed in most fracture neck of femur (fnf) cases. it is justified by the reasonable operative time, low blood loss and acceptable functional outcomes. the dual mobility cup total hip replacement (dmtha) has emerged as a relevant alternative to ba. since then, there is an on-going debate on the best implant to use. age, co-morbidities, patient independence and potential surgical complications must be considered when deciding between implants. the risk of dislocation is a crucial factor because of its important consequences. the investigators evaluated the functional and mechanical outcomes of ba versus dmtha in fnf in active elderly patients.


Eligibility criteria:
inclusion criteria: * active patients * displaced fracture neck of femur * age from 60 to 80 exclusion criteria: * ipsilateral previous hip surgery * grade 3 hip osteoarthritis according to tonnis classifiction * dysplastic acetabulum
endoscopic mucosal resection (emr) in barrett's esophagus

Conditions: Barrett's Esophagus; Early Esophageal Adenocarcinoma

Summary: existing records will be reviewed to evaluate the predictors of complications including stricture formation, bleeding or perforation associated with endoscopic mucosal resection

barrett's esophagus (be) is a complication of gastroesophageal reflux disease in which the normal squamous lining of the esophagus is replaced by specialized columnar epithelium.1 approximately 5%-10% of patients diagnosed with be are thought to be at risk of developing esophageal adenocarcinoma.2 patients with high-grade dysplasia (hgd) on biopsy are at the greatest cancer risk³. emr is being performed clinically in our barrett's esophagus unit on a regular basis during endoscopy for patients with barrett's esophagus and/or early esophageal adenocarcinoma. there are two predominant endoscopic mucosal resection (emr) techniques exist using fda approved devices - the emr cap method using a transparent cap/snare combination and the endoscopic variceal ligation method using a band ligator/snare combination to resect tissue.

Eligibility criteria:
inclusion criteria: * barrett's esophagus early esophageal adenocarcinoma history of endoscopic mucosal resection exclusion criteria: * na

Keywords: endoscopic mucosal resection