Kornimate/medical-research-clean huggingface dataset:
the phenomenon of "chronic lyme"; an observational study

Conditions: Chronic Lyme Borreliosis

Summary: the current study is set up to chart clinically and laboratory findings in norwegian patients with symptoms attributed by themselves or their doctor to ongoing chronic bb infection. objectives is to assess laboratory findings in relation to established diagnostic criteria and to form a picture of the burden of symptoms and illness perception in this group of patients. the study is essentially exploratory, and is supposed to raise rather than to test hypotheses.


Eligibility criteria:
inclusion criteria: * symptoms attributed by themselves or their doctor to ongoing chronic bb infection exclusion criteria: * none
physiology and residual ischemia after percutaneous coronary intervention

Conditions: Ischemic Heart Disease; Angina Pectoris; Chest Pain; Coronary Artery Disease; Coronary Restenosis

Summary: despite optimal angiographic result after stent implantation, a number of patients will undergo repeat angiography within 1 year of index procedure. easy-pripci is an observational study evaluating the incidence of abnormal physiology results in patients undergoing repeat angiography after uncomplicated percutaneous intervention (pci).

despite successful pci and complete revascularization, about 25% of patients will present with angina and/or positive exercise testing during follow-up. with recurring or persistent symptoms, a number of those patients will be referred for control angiography. this might create a significant burden for health systems as well as putting patients to undergo further interventions without clear demonstration of ischemia. assessing physiology and fractional flow reserve in particular after pci could represent a further step to determine whether stent implantation and stenosis removal will be effective to relieve subjective and objective signs of ischemia. hypothesis: resting gradients such as whole cycle pd/pa and diastolic dpr and ffr will be abnormal (below ischemic threshold) in \> 20% of cases despite optimal stent implantation and angiographic result. the use of physiology assessment in previously intervened vessels in patients referred for persisting or recurring angina might help operators to decide upon further intervention.

Eligibility criteria:
inclusion criteria: * any patient referred for diagnostic angiography and possible pci within 12 months of uncomplicated pci with stent implantation. exclusion criteria: * unable to understand study design or objectives of study. * unable to sign informed consent. * evidence of in-stent restenosis or significant untreated coronary lesions (initial incomplete revascularization) * inability to comply with the study follow-up

Keywords: coronary artery disease fractional flow reserve (ffr) coronary physiology repeat intervention diastolic pressure ratio (dpr)
optimal type 2 diabetes management including benchmarking and standard treatment.

Conditions: Diabetes

Summary: demonstrate that the use of benchmarking improves quality of patient care, in particular the control of diabetes, lipids and blood pressure, by determining the percentage of patients in the benchmarking group achieving pre-set targets for hba1c 14,18, ldl-cholesterol16,18 and systolic blood pressure17,18 versus control group (non-benchmarking group) after 12 months of follow-up.


Eligibility criteria:
inclusion criteria: * provision of informed consent * patients suffering from diabetes type ii, insulin dependent or not insulin dependent. exclusion criteria: * type i diabetes * pregnancy diabetes * hospitalisation, as this is a primary care study * patients who are member of the belgian diabetes convention

Keywords: diabetes benchmarking quality of patient care diabetic population
a study of argx-110 in patients with nasopharyngeal carcinoma (npc)

Conditions: Cancer

Summary: to characterize the safety profile of argx-110 administered as mono- or combination therapy to patients with npc at various stages of its natural history (adjuvant vs. metastatic).


Eligibility criteria:
inclusion criteria: * age ≥18 years. * written informed consent prior to any study-related procedure * willing and able to comply with protocol-specified procedures and scheduled evaluations * pathological diagnosis of nasopharyngeal carcinoma (npc) * eastern cooperative oncology group (ecog) performance status of 0, 1or 2 * absolute neutrophil count (anc) \> 0.5 x 109/l * haemoglobin \> 80 g/l * platelet count ≥ 50 x 109/l * total bilirubin ≤ 2 x the upper limit of normal (uln) * alanine transaminase (alt) ≤ 5 x uln * serum creatinine ≤ 2 x uln exclusion criteria: * history or clinical evidence of neoplastic central nervous system (cns) involvement. note: irradiated brain metastases that have been stable for \> 1 month and do not require systemic glucocorticoid administration are allowed * major surgery within 4 weeks of argx-110 first dose administration * unresolved grade 3 or 4 toxicity from prior therapy (except mucositis from local radiation therapy). * active, untreated viral, bacterial, or systemic fungal infection * childbearing potential unless using an adequate measure of contraception * pregnancy or lactation. history of hypersensitivity to recombinant proteins * any clinical finding, including psychiatric and behavioural problems, which, in the opinion of the investigator, precludes the patient from safely participating in the study
prospective randomized controlled multicenter trial of 4 antiseptic strategies for prevention of catheter infection in intensive care unit for adults patients

Conditions: Preventing Catheter Related Infection

Summary: catheter related infection is the third cause of nosocomial infection in icus. most of them are avoidable and can be prevent by improving aseptic practices during catheter insertion and maintenance. indeed, the main route of catheter contamination for short-term catheters is the insertion site. consequently, the quality of skin disinfection is the most effective preventive measure to reduce the incidence of these infections. this aim of the present study is to compare four strategies of skin disinfection to determine whether a 2% alcoholic solution of chlorhexidine acts better than 5% alcoholic povidone iodine in reducing catheter infection and to assess whether a detersion phase prior to disinfection reduces catheter colonization as compared with no detersion.


Eligibility criteria:
inclusion criteria: * ≥ 18 year-old * expected duration of icu stay ≥ 48 hours * patient requiring the insertion of at least one arterial catheter and/or central venous catheter and/or catheter for hemodialysis. exclusion criteria: * patient with history of allergy to any of the antiseptic agent studied * expected survival \< 48 hours * catheter inserted outside the icu or in emergency without respect of preventive measures. * use of antimicrobial impregnated catheters or antiseptic impregnated dressings. * pregnant woman or breast-feeding mother
cold snare polypectomy versus hot snare polypectomy for resection of small pedunculated colorectal polyps：a randomized controlled trial

Conditions: Pedunculated Colorectal Polyps; Haemorrhage

Summary: endoscopic resection of pedunculated polyps mainly focuses on how to prevent bleeding, and also needs to pay attention to the convenience of resection and the integrity of resection, which means that different endoscopic resection strategies should be adopted for pedunculated polyps with different stalk sizes. small pedunculated polyps with heads smaller than 20mm and stalks less than or equal to 5mm are defined as having a relatively small risk of bleeding. preliminary studies in recent years suggest that the use of cold snare polypectomy for small pedunculated polyps may also be a safe resection strategy. however, for small pedunculated polyps, asge and esge guidelines currently recommend hot snare polypectomy in the middle and lower pedicles (evidence level medium). therefore, the provision of high-quality clinical evidence related to cold resection techniques in the resection strategy of small pedunculated polyps may provide a basis for revision of guidelines.


Eligibility criteria:
inclusion criteria: * 1. patients undergoing endoscopic resection of small pedicled polyps in the first affiliated hospital of ningbo university from october 2023 to august 2026; 2. patients who voluntarily agreed to participate in this study and signed informed consent. exclusion criteria: * 1. persons under 18 years of age 2. persons unwilling or unable to provide informed consent 3. treatment or radiotherapy for malignant diseases, severe chronic heart or lung diseases, coronary or cerebrovascular events requiring hospitalization within the last 3 months 4.malignant polyps have infiltrated the pedicle 5. abdominal symptoms such as severe abdominal pain, abdominal distension, and nausea 6.patients with inadequate intestinal preparation 7. patients with lifelong anticoagulant therapy or severe bleeding diseases, patients who have recently taken anticoagulant drugs or antiplatelet drugs (within 1 week) 8.pregnant or lactating
assessment of post-operative pain after different instrumentation techniques in pulpectomy treatment of primary molars

Conditions: Pulp Necroses

Summary: the goal of this clinical trial is to compare the post operative pain after using three different instrumentation techniques in pulpectomy treatment of pediatric participant. the main question it aims to answer: if different instrumentation techniques will affect the post operative pain in pulpectomy treatment of primary molars ? participants will evaluate the pain using modified wong baker pain rating scale. researchers will compare \[ the adaptive xp endo shaper, fanta af baby files, and hand k files\] to see if they will affect the post operative pain.


Eligibility criteria:
inclusion criteria: * cooperative children free from systemic diseases. * teeth with sufficient coronal tooth structure. * teeth with necrotic pulp. * teeth should have 2/3 of the remaining roots. exclusion criteria: * children taking medications up to six hours before the treatment. * children with multiple teeth that required pulpectomy will not be included to eliminate the possibility of pain referral. * excessive tooth mobility. * teeth with perforated pulpal floor. * teeth with external or internal root resorption.

Keywords: pulpectomy, xp endo shaper, post operative pain
heart failure medication adherence

Conditions: Heart Failure

Summary: the objective of this investigation is to pilot test a medication in-hand intervention (meds to beds) compared to standard care for patients with heart failure (icd-50\[all numbers\]). the study will evaluate if the intervention improves adherence and physical health, and reduces hospital re-admissions. the study will provide evidence for the feasibility and acceptability of the medication-in-hand intervention.


Eligibility criteria:
inclusion criteria: * admission diagnosis of heart failure icd-50, including i50.1, i50.2, i50.20, i50.21, i50.22, i50.23, i50.3, i50.30, i50.31, i50.32, i50.33, i50.4, i50.40, i50.41, i50.42, i50.43, i50.8, i50.81, i50.810, i50.811, i50.812, i50.813, i50.814, i50.82, i50.83, i50.84, i50.89, i50.9, or any combination thereof * age 18 or older * new york heart association heart failure class ii or class iii, with ejection fraction below 45% * cognitively intact, without significant psychological impairment affecting medication adherence such as dementia noted in patient record. exclusion criteria: * medical conditions, such as active cancer or pregnancy, expected to alter heart failure medication management * discharged to nursing homes or hospice care, where patient may not responsible for their own adherence * high risk of loss to follow-up, e.g., leaving the hospital against medical advice, prisoners, living in a homeless shelter, or unable to provide a phone number * no plan to fill medications at the jackson memorial hospital pharmacy

Keywords: adherence, medication, prescription
functional outcome in patients that underwent laparoscopic sigmoid and/or rectum resection

Conditions: Endometriosis

Summary: questionnaire to assess the functional outcome in patients that underwent laparoscopic sigmoid and/or rectum resection.

a questionnaire will be sent to every patient by mail. the questionnaire that will be used is the corefo questionnaire (colorectal functional outcome). depending on the amount of responses, we will try to make connections between peri-operative data and functional outcome after considerable period of follow-up. peri-operative factors include grade of endometriosis, surgical technique and post-operative complications.

Eligibility criteria:
inclusion criteria: * patients that underwent laparoscopic sigmoid and/or rectum resection with the indication of deep infiltrating endometriosis exclusion criteria: -

Keywords: deep infiltrating endometriosis laparoscopic sigmoid resection laparoscopic rectum resection colorectal surgery
endometrial cancer recurrence in patients taking metformin

Conditions: Recurrent Endometrial Carcinoma

Summary: given the early literature available and its biological plausibility as an inhibitor of the mammalian target of rapamycin (mtor) protein, it is hypothesized that women with endometrial cancer who take metformin for non-cancer related reasons have a lower cancer recurrence rate compared to women not taking metformin. the primary goal of this study is to determine whether metformin use is associated with a decrease in the rate of endometrial cancer recurrence. secondary objectives are to assess whether women with endometrial cancer taking metformin have longer progression free survival and overall survival than those that do not take metformin.

this is a retrospective chart review study. medical records are reviewed and data collected through the hospital's electronic medical record (emr). participants are women that had definitive treatment for endometrial cancer between 2016-2020 at wellspan york hospital department of gynecologic oncology. participants are identified and their chart reviewed for demographic data of age, race, comorbid conditions, and use of metformin. possible confounding information is documented, including chemotherapy status, radiotherapy status, cancer and tumor type, grade, and stage, available genetics information, medications at the time of cancer diagnosis, and medication durations. those patients who had cancer recurrence are identified. recurrence data including type, time interval, additional treatment are collected. recurrence is defined as any recurrence validated by clinical, imaging and histological data and can be identified based on the cancer registry. recurrence rate in participants that took metformin vs. those that did not is calculated. time to endometrial cancer recurrence is calculated. progression free survival and overall survival are calculated. statistical analysis is performed to compare each of these outcomes between participants who took metformin vs. those that did not.

Eligibility criteria:
inclusion criteria: * participants with endometrial cancer of all histologies treated in the wellspan system from 2016-2020 exclusion criteria: * participants who underwent palliative treatment for endometrial cancer

Keywords: metformin endometrial cancer
wei nasal jet tube vs nasal cannula oxygen support in gastrointestinal endoscopy patients

Conditions: Supraglottic Airway Obstruction; Airway Complication of Anesthesia; Airway Obstruction; Anesthesia Complication; Bronchospasm; Nasal Bleeding; Oxygen Deficiency

Summary: sedoanalgesia is applied to patients during gastrointestinal endoscopy. sedoanalgesia may cause respiratory depression and hypoxia in patients. during these procedures, patients should be given oxygen support to reduce the incidence of hypoxia.this study aimed to compare the efficacy and procedural performance of two different airway devices (wei nasal jet tube vs nasal cannula oxygen support) in gastrointestinal endoscopy

gastrointestinal endoscopy is performed as standard for the diagnosis of many gastrointestinal diseases. during gastrointestinal endoscopy, sedoanalgesia is applied to relieve patients' pain and increase patient comfort. anesthetic drugs used for sedoanalgesia may cause respiratory depression and hypoxia in patients. hypoxia resulting from hypoventilation in patients is responsible for many events, including coronary ischemia. during these procedures, patients should be given oxygen support to reduce the incidence of hypoxia. the purpose of this procedure is to provide safe oxygenation and ventilation. while providing oxygen support, nasal cannula, classical oxygen mask can be used, as well as new generation oxygenation devices. our study will show us which method is more beneficial in preventing hypoxia and other side effects, providing comfort for the doctor performing the procedure and for the patient undergoing the procedure. this study aimed to compare the efficacy and procedural performance of two different airway devices (wei nasal jet tube vs nasal cannula oxygen support) in gastrointestinal endoscopy

Eligibility criteria:
inclusion criteria: * patients undergoing gastrointestinal endoscopy * asa physical status 1-2 * body mass index 18.5 - 35 kg/m2 exclusion criteria: * high risk of pulmonary aspiration * pregnancy * anesthesic drug allergies * difficult airway or facial deformities * height \<155 cm * alcohol or narcotic drug usage * restrictive or obstructive pulmonary diseases * hepatic cardiac or renal failure * neurologic or cognitive deficiencies. * previous cervical surgery or cervical radiotherapy * previous esophagus surgery * psychotic problems

Keywords: wei nasal jet tube airway complication nasal cannula oxygen support gastrointestinal endoscopy sedation
influenza vaccine revaccination in ambulatory elderly subjects

Conditions: Influenza; Orthomyxovirus Infection; Myxovirus Infection

Summary: this is a multi-center study designed to evaluate the safety and immunogenicity of a fluzone revaccination in elderly adults aged ≥ 65 years. primary objective: to describe the safety profile for all subjects. secondary objective: to describe immunogenicity 28 days following revaccination with one of three fluzone formulations.

subjects who previously participated in study fid29 will be invited to participate in this revaccination study. they will be assigned to 1 of 3 groups based on the group they were previously randomized to and the vaccine received in study fid29.

Eligibility criteria:
inclusion criteria : * aged ≥ 65 years on the day of vaccination * enrolled in and completed study fid29 and received the correct vaccine for the group to which they were randomized * informed consent form signed and dated * able to attend all scheduled visits and to comply with all trial procedures * subject is medically stable. exclusion criteria : * known systemic hypersensitivity to any of the vaccine components or history of a life-threatening reaction to the trial vaccine or to a vaccine containing any of the same substances * participation in another clinical trial investigating a vaccine, drug, medical device, or a medical procedure in the four weeks preceding the trial vaccination * planned participation in another clinical trial during the present trial period * known or suspected congenital or acquired immunodeficiency, immunosuppressive therapy such as anti-cancer chemotherapy or radiation therapy within the preceding 6 months, or long-term systemic corticosteroids therapy * chronic illness, at a stage that could interfere with trial conduct or completion, in the opinion of the investigator * current alcohol abuse or drug addiction that may interfere with the subject's ability to comply with trial procedures * receipt of blood or blood-derived products in the past 3 months, that might interfere with the assessment of immune response * receipt of any vaccination in the 4 weeks preceding the trial vaccination * planned receipt of any vaccine in the 4 weeks following the trial vaccination * known human immunodeficiency virus (hiv), hepatitis b (hbs) antigen, or hepatitis c seropositivity. * previous vaccination against influenza in the past 6 months with the trial vaccine or another vaccine * thrombocytopenia, bleeding disorder or anticoagulants in the 3 weeks preceding inclusion contraindicating intramuscular (im) vaccination * subject deprived of freedom by an administrative or court order, or in an emergency setting, or hospitalized without his/her consent * neoplastic disease or any hematologic malignancy, (except localized skin or prostate cancer that is stable at the time of vaccination in the absence of therapy, as well as subjects who have a history of neoplastic disease and who have been disease free for ≥ 5 years). * personal or family history of guillain-barré syndrome.

Keywords: influenza orthomyxovirus infection inactivated split-virion influenza vaccine elderly
expression of g-protein coupled receptor 120 receptor in adipose tissue of german diabetes center cohort subjects

Conditions: Type 2 Diabetes

Summary: g-protein coupled receptor 120 (gpr120) is a g-protein-coupled receptor whose endogenous ligands have been identified as long-chain fatty acids. recently, it has been shown that gpr120 expression in human adipose tissue is higher in obese than in lean individuals. interestingly, a gpr120 deficient mouse model presents an unfavorable phenotype when fed a high-fat diet with obesity, glucose intolerance and fatty liver, characteristics also found in type 2 diabetes (t2d). moreover, in obese subjects, a single nucleotide polymorphism (r270h) has been identified that inhibits gpr120 signaling activity. the investigators now want to investigate if gpr120 expression in adipose tissue may be altered in patients with t2d compared to non-diabetic subjects and might contribute to diabetes-associated metabolic changes. additionally, the investigators want to assess the frequency of the r270h mutant in t2d.


Eligibility criteria:
inclusion criteria: * type 2 diabetes mellitus / normoglycemia * bmi \ 30 kg/m2 * age 20 - 69 years exclusion criteria: * severe chronic diseases * anemia * medication altering fatty acid metabolism

Keywords: gpr120 adipose tissue type 2 diabetes