Kornimate/medical-research-clean huggingface dataset:
incidence of acute cerebrovascular events using either minimized or standard cardiopulmonary bypass circuit

Conditions: Coronary Artery Disease; Acute Cerebrovascular Accident; Intracranial Embolism; Embolism, Air

Summary: the prospective, randomized, two centre study investigates acute cerebrovascular events during extracorporal circulation and the early post operative outcome when using either the minimized cardiopulmonary bypass circuit (rocsafetm) or a standard cardiopulmonary bypass circuit in patients undergoing coronary artery bypass grafting.

coronary artery bypass grafting with extracorporal circulation is established as the golden standard. the conventional cardiopulmonary bypass (cpb) system is associated with inflammatory reaction, hemolysis, hemodilution an disturbances of the blood coagulation system. also it's well known that neurological disturbances caused by embolic material and air bubbles are potential risks of cpb. the new minimized perfusion circuit rocsafetm is a closed, reservoir-less, reduced prime, surface coated circuit, with optimized safety features in effectively eliminate both macro and micro air bubbles and should optimize the clinical outcome after cabg using cardiopulmonary bypass.

Eligibility criteria:
inclusion criteria: * patient is older than 17 years * patient is acceptable candidate for cabg operation * patient or the patient's legal representative has been informed of the nature of the study and agrees to its provisions and has provided written informed consent. exclusion criteria: * ejection fraction less than 30 % * valve surgery * acute endocarditis or history of endocarditis * cerebral ischemia within 4 weeks before surgery * detection of intracardial thrombi in preoperative echocardiography * stenosis of a. carotis int. greater than 70 % * patients older than 80 years * patients on dialysis * acute myocardial ischemia or infarction within two weeks before inclusion * markedly elevated baseline c-reactive protein (crp) or leucocytosis * cancer or immunologic diseases * dysregulation of the coagulation cascade (not concerning inr or ptt under cumarin or heparin treatment) * intake of steroids or nsar * female of childbearing potential * participation in an other study * contraindication for mri (e.g. pacemaker, any kind of implanted metal) * claustrophobia

Keywords: coronary artery bypass surgery cardiopulmonary bypass heart lung machine acute cerebrovascular event intracranial embolism embolism, air outcome assessment (health care) neuropsychological tests magnetic resonance imaging saccadic eye movement test
prediction of thrombosis using d-dimer trends in covid-19

Conditions: Covid19

Summary: a high incidence of venous thromboembolic events (vte) has been demonstrated in covid-19. this incidence correlates with disease severity. activation of coagulation secondary to sepsis combined with classical thrombotic risk factors may contribute to this prothrombotic state. since the beginning of march 2020, the issue of venous thrombosis during sars-cov-2 infection has rapidly emerged as a major medical challenge since a significant rate of patients were thrombosing, some of them in spite of a well conducted preventive anticoagulation. although d-dimers have been shown to be useful in identifying patients at risk of severe covid-19 and even mortality, they cannot be used for diagnostic exclusion of pulmonary embolism. indeed, since d-dimer levels rise non-specifically during infectious states, the exclusion threshold of 500 ng/ml cannot be used. it would therefore be useful to study the predictive value of d-dimers for thrombosis in covid-19 patients.

primary outcome : characterize different d-dimer trends in covid-19 patients. secondary outcomes : * identify the predictive value of different d-dimers trends for thrombosis / all-cause mortality / orotracheal intubation during hospitalization * identify the predictive value of d-dimers at admission for thrombosis / all-cause mortality / orotracheal intubation during hospitalization * identify the predictive value of 1st d-dimer/fibrinogen ratio for thrombosis / all-cause mortality / orotracheal intubation during hospitalization

Eligibility criteria:
inclusion criteria: positive sars-cov-2 pcr and at least one d-dimer result non inclusion criteria: below 18 yo
changes in postural stability following tha for oa

Conditions: Osteoarthritis, Hip

Summary: total hip arthroplasty (tha) is a common surgery that eases pain, restores functional movement, and improves the overall quality of life in people with severe hip osteoarthritis (oa). unfortunately, problems with postural stability, commonly known as balance, are still noticed in people even years after the surgery. these postural stability problems typically result in falls. the aim of the proposed study is to investigate how tha surgery affects a person's overall quality of life, both physically and psychologically, in terms of postural stability and balance confidence (self-efficacy) within the first three months after tha for osteoarthritis. this prospective cohort study will focus on people over 60 years old.

the purpose of this study is to evaluate the changes in postural stability and balance confidence during the initial three months after elective unilateral total hip arthroplasty for osteoarthritis. specifically, the investigators aim to: 1. to evaluate change in postural stability between the da and dl surgical approaches during the first three months after elective unilateral tha for oa, using both a clinical measure and an instrumented measure. 2. to evaluate change in balance confidence between the da and dl surgical approaches during the first three months after elective unilateral tha for oa. secondary objective 3. to compare the da and dl approaches for activity levels, function, quality of life and pain during the first three months after elective unilateral tha for oa.

Eligibility criteria:
inclusion criteria: * ≥ 60 years of age, scheduled to receive an elective unilateral tha (da or dl approach) for oa * ambulatory for a minimum of 10 meters with or without a mobility aid but without the assistance of another person * able to read, write and speak english * able to provide consent exclusion criteria: * bilateral tha * underwent tha surgery for a diagnosis other than oa * any condition that will prevent participants from completing the study such as having a significant neurological, cardiovascular, musculoskeletal condition as denoted by their physician.

Keywords: postural stability total hip arthroplasty balance confidence osteoarthritis fall
i-stand r21: reducing sedentary time in older adults

Conditions: Obesity; Sedentary Lifestyle

Summary: the investigators are doing a study to learn how to support patients aged 60+ in taking more breaks from sitting and reducing total sitting time. the goal of the study is to find out if a sitting time reduction intervention reduces sitting time compared with a control group.

more than one-third of american adults over 60 have a body mass index \> 30 kg/m2. these older adults have more sedentary time than any other group -- an average of 10-11 hours per day. reducing the sedentary behavior of older adults with obesity, rather than only promoting more intensive physical activity, could provide a more feasible approach to health promotion. this randomized control pilot trial will evaluate a 12-week intervention to decrease sitting time and increase standing time and light physical activity among sedentary older adults a body mass index \> 30 kg/m2 as compared to control group. baseline and 12-week measurements include anthropometric measures, blood draw by finger stick, cardiovascular health assessments, physical function tasks, and a survey. the intervention will consist of two in-person visits with a health coach followed by phone-based coaching.

Eligibility criteria:
inclusion criteria: * kaiser permanente washington enrollees * men and women * age 60 - 89 * bmi 30 - 50 (calculated based on most recent height ever and most recent weight taken within previous 18 months) * primary care within integrated group practice * continuously enrolled at kaiser permanente washington for previous 12 months * no record of death * not on the no contact list * speaks and writes english * able to hold a conversation by phone (no hearing or other limitations) * self-reported sitting time of 6 hours/day or more * self-reported ability to stand with or without an assistive device * self-reported ability to walk one block with or without an assistive device * available for the study duration * able to come to kaiser permanente washington health research institute's research clinic for measurement visits * willing to wear study activity monitors exclusion criteria: * resides in long-term care, hospice care, or skilled nursing facility (previous 12 months) * wheelchair bound * diagnosis of dementia, serious mental health disorder, or substance use disorder (previous 24 months) * use of an assistive device

Keywords: sedentary time sit-to-stand transitions
four-unit implant supported fixed partial dentures fabricated from different materials

Conditions: Prosthesis Survival; Bone Loss

Summary: implant supported superstructure is necessary for long term success and durability of the implant itself in terms of stresses distribution and fracture strength capability. stresses falling on an implant are too much greater than those applied on a tooth structure with a periodontal ligament offering a degree of elasticity. the important mechanical and physical properties of materials used for the fabrication of dental prostheses include adequate flexural and tensile strength and modulus of elasticity, maximum fracture resistance, optimal bond strength and adequate polishability.

one objective of implant dentistry is to provide excellent esthetics and soft-tissue profiles in the esthetic zone. esthetic requirements have focused primarily on the position, inclination, shape, and color of the restoration. however, the peri-implant soft tissue also plays a major role in the esthetics of an implant-supported restoration especially in the anterior region.

Eligibility criteria:
inclusion criteria: * no systemic diseases that might alter the tissue response to implantation. * mobility grade 3 at the site of the 4 lateral incisors. * sufficient available inter-arch space * normal maxillomandibular relation. * no temporomandibular joint exclusion criteria: * grade 1 or 2 mobility at the incisor's region. * patients with systematic diseases that contraindicate implant placement.
comparative effects of plyometric training and theraband resistant exercises in karate players

Conditions: Sports Physical Therapy

Summary: the aim of this study is to find out the comparative effects of plyometric training and theraband resistant exercises on agility, power and dynamic balance in karate players with patellofemoral syndrome. understanding how these methods impact agility, power, and dynamic balance provides practical insights for designing rehabilitation programs.it help therapists to find which evidence-based recommendations are beneficial for maximizing the athletes agility, power, dynamic balance and overall performance or well-being of the karate players with patellofemoral pain syndrome.

the literature gap in this study on the comparative effects of plyometric training and theraband resistant exercises on agility, power and dynamic balance in karate players with patellofemoral syndrome may exist, there might be limited studies specifically addressing this unique combination of factors, further investigation is needed to explore the evidence based effect of these exercises on karate players with patellofemoral syndrome, considering the interplay between the exercises and the sport specific demands.

Eligibility criteria:
inclusion criteria: * males * age 18 to 25 years * with playing experience of 3 to 5 years will be included * minimum sports activity 1 hour 4 times a week * positive patella femoral compression test (pain is in around the patella and back of knee cap) exclusion criteria: * recreational players * players with recent injury in past 6 months * any musculoskeletal and neurological problem * player addicted to any drug or alcohol will be excluded

Keywords: muscle imbalance patellofemoral pain theraband resistance exercises
lods role in predicting 30-day mortality outcome in icu

Conditions: Mortality

Summary: lods score for deceased icu patients within 30 days is higher than survived icu patients


Eligibility criteria:
inclusion criteria: * adult patient (age 18 years and above) admitted to icu exclusion criteria: * patients admitted to icu due to burn injury, coronary artery disease, post cardiac surgery * patients with incomplete required information for lods score * patients deceased or discharged less than 24 hours of admission

Keywords: intensive care unit logistic organ dysfunction system 30-day mortality sepsis mortality prediction
the effect of nursing support program for women in surgical menopause on their life quality

Conditions: Nursing Caries; Surgical Menopause; Quality of Life

Summary: objective: the aim of this study was to determine the effect of the nursing support program developed in line with the roy adaptation model on the quality of life, sleep quality and depressive symptom status of women in surgical menopause. design: the study was a single-center, randomized, controlled trial. setting: this study was carried out in the gynecology clinic of a training and research hospital in türkiye. method: the participants were randomized into two equal groups: intervention and control. the nursing support program developed in addition to routine nursing care was applied to the intervention group. routine nursing care was given to the women in the control group. data were collected with "personal information form", "menopause-specific quality of life questionnare", "pittsburgh sleep quality index" and "perimenopausal depression scale". hypothesis: h0-a: nursing support program developed in line with the roy adaptation model has no effect on the quality of life of women who have undergone surgical menopause. h0-b: nursing support program developed in line with the roy adaptation model has no effect on the sleep quality of women who have undergone surgical menopause. h0-c: nursing support program developed in line with the roy adaptation model has no effect on the depressive symptom status of women who have undergone surgical menopause.


Eligibility criteria:
inclusion criteria: * to have undergone surgical menopause * to be literate * to agree to participate in the study exclusion criteria: * to have natural menopause before the operation * to have an oncological disease * to have a psychiatric disease * to use sleeping pills * to use hormonal therapy * to have physical and mental disability * to have barrier to communication

Keywords: nursing support program roy adaptation model depressive symptom status sleep quality
effect of a modified propofol preparation on injection pain during induction of anesthesia in children

Conditions: Anesthesia

Summary: the purpose of the study is to determine wether a modified propofol preparation shows any effect on the incidence of injection pain in children undergoing elective surgery under general anesthesia. study hypothesis: the use of a modified propofol preparation will reduce the incidence of injection pain in the study group.

pain on injection is the most frequently reported side effect associated with the use of propofol for induction of anesthesia. various measures have been taken to reduce the pain on injection, e.g. administration of lidocaine or fentanyl prior to propofol administration, mixture of lidocaine and propofol as well as cooling of the emulsion. although pain on injection had been reduced with some of the above mentioned methods, they may not be regarded as a satisfactory solution of the problem.

Eligibility criteria:
inclusion criteria: * age \>= 2 and \< 6 years * written informed consent of the parents * anesthetic risc classified as asa i - iii * patient undergoing elective surgery under general anesthesia * venous access for induction of anesthesia on the dorsum of the hand * hospital care for at least 3 hrs after end of anesthesia guaranteed exclusion criteria: * intolerability of the drugs tested * current drug medication with sedative effect * patient is expected to require concomitant medication not allowed in the study * history of or current renal or hepatic disease, cardiac insufficiency * hypovolemia * increased cranial pressure * simultaneous participation in another clinical trial or participation during the month preceding this study
study to evaluate the efficacy and safety of gsk239512 in schizophrenia

Conditions: Schizophrenia

Summary: this study aims to evaluate the cognitive enhancing effects and tolerability of gsk239512 compared to placebo in patients with schizophrenia

this is a 7-week, phase ii, multi-centre, randomised, double-blind, placebo-controlled, parallel group design study in male and female subjects with schizophrenia who are stabilised on antipsychotic medication. subjects will be randomised to receive either gsk239512 or placebo for 7 weeks. they will undergo weekly review of safety, tolerability and cognitive performance measures.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of schizophrenia 2. no acute exacerbation of symptoms requiring hospital admission or step up care in the previous six months. 3. not on any symptomatic treatment for cognition exclusion criteria: 1. poses a significant homicidal or suicidal risk or evidence of previous homicidal or suicidal risk. 2. co-morbid psychiatric or significant physical illness 3. alcohol or drug abuse or dependence.

Keywords: h3 antagonist schizophrenia double blind histamine randomised placebo controlled cognition
study of fmt combined with nivolumab in gastric cancer

Conditions: Gastric Adenocarcinoma; Esophagogastric Junction Adenocarcinoma; Esophagus Adenocarcinoma

Summary: this study is a single-arm, single center study. the purpose of this study is to evaluate the efficacy and safety of fmt capsules xbi-302 combined with nivolumab in the treatment of anti-pd-1/l1 resistant gastric cancer.

the primary purpose of this single-arm, open-label, single center trial is to evaluate the efficacy and safety of xbi-302 combined with nivolumab in the treatment of anti-pd-1/l1 resistant gastric cancer. during treatment period, all eligible subjects will receive xbi-302 with nivolumab following gut preparation. the imaging evaluation of efficacy will be performed every 6 weeks.

Eligibility criteria:
inclusion criteria: * voluntarily participate in this study and provide written informed consent * age ≥ 18 years and ≤70 years, male or female * pathological confirmed locally advanced, unresectable or metastatic gastric adenocarcinoma, esophagogastric junction adenocarcinoma and lower esophagus adenocarcinoma that are resistant to anti-pd-1/l1 antibodies * able and willing to provide tumor tissue * at least one measurable extracranial target lesion according to irecist * eastern cooperative oncology group (ecog) performance status of 0 or 1 * life expectancy ≥3 months exclusion criteria: * history of other primary malignancies within 5 years except adequately treated in situ carcinoma of the cervix or non-melanoma carcinoma of the skin * had systemic diseases that were difficult to control within 4 weeks prior to screening * history of anti-pd-1 antibodies related adverse reactions that led to the permanent withdrawal of anti-pd-1 therapy * history of coagulation disorders * mechanical or paralytic obstruction of the gastrointestinal tract * anticipated to receive a great number of antibiotics during study period
dobutamine stress echocardiography in cardiac resynchronization therapy (crt) patients selection

Conditions: Heart Failure

Summary: while cardiac resynchronization therapy (crt) has a well demonstrated therapeutic effect in selected patients with advanced heart failure (hf) on optimized drug therapy, non-responder rate remains high. the low-dose dobutamine stress-echo (dse) test to predict positive response to crt (lodo-crt) trial is designed to improve patient selection for crt.

lodo-crt is a multicenter prospective study enrolling hf patients with conventional indication to crt (symptomatic stable nyha class iii-iv on optimized drug therapy, qrs≥120 msec, left ventricular (lv) dilatation, lvef≤35%) is designed to assess the predictive value of lv contractile reserve (lvcr), determined through dse, in predicting crt response during follow-up. assessment of crt effects will follow two sequential phases: in phase 1 crt response end-point is defined as left ventricular end-systolic volume (lvesv) reduction ≥ 10% at 6 months; in phase 2, both lvesv reduction and clinical status via a clinical composite score will be evaluated at 12 months follow-up. predictive value of lvcr will be compared to other measures, such as lv dyssynchrony measures, through adjusted multivariable analysis. for the purpose of the study, target patient number is 270 patients (with 95% confidence, 80% power, α≤0.05). lvcr assessment, using low-dose des test, should effectively predict positive response to crt both in terms of the reverse remodeling process as well as favorable long-term clinical outcome. moreover, the predictive value of lvcr will be compared to that of conventional intra-lv dyssynchrony measures.

Eligibility criteria:
inclusion criteria: * severe hf despite optimized medical therapy * nyha functional class iii-iv * dilated cardiomyopathy of both ischemic and non-ischemic origin * left ventricular ejection fraction (lvef) \<=35% * qrs complex duration ≥120 ms * normal sinus rhythm. exclusion criteria: * younger than 18 years old * unstable angina * acute myocardial infarction * coronary artery bypass graft (cabg) or percutaneous transluminal coronary angioplasty (ptca) within the past 3 months * already implanted with a conventional implantable pulse generator or with an implantable cardioverter defibrillator (icd) * previously implanted with a crt device * chronic permanent atrial arrhythmias

Keywords: heart failure crt dobutamine echocardiography
effect of non-surgical periodontal treatment on lipoxin a4 levels

Conditions: Periodontitis

Summary: the aim of this study was to evaluate the levels of lipoxin a4 (lxa4), prostaglandin e2 (pge2) and leukotriene b4 (ltb4) in gingival crevicular fluid (gcf) and saliva in individuals with periodontal healthy and chronic periodontitis. in addition, the investigators evaluated the levels of these mediators after non-surgical periodontal treatment in patients with chronic periodontitis. a total of 20 subjects, 10 patients with chronic periodontitis (cp) and 10 periodontally healthy individuals were included in the study. clinical parameters including plaque index (pi), gingival index (gi), probing depth (pd) and clinical attachment levels (cal) were recorded. gcf and saliva samples were obtained at the beginning of the study from all individuals. gcf and saliva samples were re-collected from patients with cp at 1 month after non surgical periodontal therapy.


Eligibility criteria:
inclusion criteria: * have at least 20 natural teeth, excluding third molars. * chronic periodontitis patients had at least two non-adjacent sites per quadrant with probing depth (pd) ≥ 5 mm and clinical attachment level (cal) ≥ 5 mm with gingival inflammation, and alveolar bone loss affecting \>30% of the teeth, as detected on clinical and radiographical examinations. * periodontally healthy control group had no sign of gingival inflammation, no pd \> 3mm and no evidence of attachment or bone loss. exclusion criteria: * history of systemic disease. * regular use of any drugs which can effect the immune system or inflammatory response in the 6 months preceding the start of the study. * periodontal treatment during last 6 months that could affect periodontal status. * smoking. * history of radiotherapy or chemotherapy. * ongoing orthodontic treatment. * aggressive periodontitis. * current pregnancy, lactation or menopause.

Keywords: gingival crevicular fluid lipid mediator periodontal treatment