Kornimate/medical-research-clean huggingface dataset:
reliability and validity of dida-q in parkinson's disease

Conditions: Parkinson Disease

Summary: the aim of our study is to investigate the validity and reliability of the dual task impact on daily-living activities (dida-q) to assess the degree of difficulty felt when performing dual tasks during activities of daily living in patients with parkinson's disease. in our study, the validity and reliability of a questionnaire to assess the degree of difficulty felt while performing dual tasks during activities of daily living in parkinson's disease will be examined for the first time. the study will include 95 participants with hoehn-yahr stage 1-3, diagnosed with idiopathic parkinson's disease and able to walk 10 metres without an assistive device.

dual task ability is defined as the ability to perform two activities simultaneously . it is known that the ability to perform a motor or cognitive secondary activity at the same time during walking (talking to a person next to you while walking or carrying objects while walking) leads to gait and balance problems of different severity depending on the type of secondary task in parkinson's disease (pd). when patients with parkinson's disease (pwpd) are exposed to dual-task walking, their walking speed and length of stride decrease, and the frequency of freezing phenomena during walking increases. consequently the risk of falling increase during activities of daily living. individuals often perform dual tasks while performing activities of daily living because of the nature of the tasks' requirements. therefore, it has become important to evaluate dual task performance in order to create the right treatment plan in the field of neurological physiotherapy and rehabilitation. although dual task performance is evaluated with different formulae in the literature, the number of scales evaluating the level of difficulty perceived by the patient during the performance of activities of daily living under dual task is limited. the validity of the existing scales for pd has not been studied. the dual-task impact on daily-living activities questionnaire (dida-q) is a patient-reported questionnaire developed to assess the degree of difficulty perceived when performing dual tasks during activities of daily living.

Eligibility criteria:
inclusion criteria: * diagnosed with idiopathic parkinson's disease according to uk brain bank criteria * walking at least 10 metres without an assistive device * to have the cognitive capability to understand and answer the questions asked in the scale exclusion criteria: * having any neurological disease other than idiopathic parkinson's disease * the person has an orthopaedic or cardiopulmonary disease that affects walking * severe hearing-visual impairment

Keywords: parkinson's disease dual-task assessment neurological physiotherapy
kontakt australia a social skills group training for adolescents on the autism spectrum

Conditions: Autism Spectrum Disorder

Summary: this study evaluates the kontakt social skills group training in australian adolescents on the autism spectrum compared to an active control group which is a group cooking class

kontakt is a manualized social skills group training program designed for children and adolescents with asd which aims to improve communication, social interaction skills, reduce the severity of asd symptoms, improve the ability to empathise and adapt in a group setting. a large randomized controlled trial in sweden found that adolescents who participated in kontakt demonstrated improvements in social skills, behaviour, reduced stress and improved overall functioning as reported by parents immediately following and at three months after the program. however, social skills are at least in part influenced by social cultural contexts and there is a need to understand the feasibility, acceptability and effectiveness of kontakt in an australian context. moreover, in the previous studies, the social skills groups were compared to treatment as usual groups. therefore, this study evaluates the kontakt social skills group training in australian adolescents on the autism spectrum compared to an active control group which is a group cooking class

Eligibility criteria:
inclusion criteria: * individuals aged 12 to 17 * clinical consensus diagnosis of asd as defined by dsm-5 and confirmed by the autism diagnostic observation schedule-2 * iq scores \> 70 as measured by the wechsler abbreviated scale of intelligence - second edition (wasi-ii) exclusion criteria: * existing prior comorbid externalizing behaviours as assessed by the childhood behaviour checklist (cbcl). * clinically assessed self-injurious behaviour * low intrinsic motivation to participate in a social skills training group * insufficient english language skills

Keywords: social skills group training adolescents active control group australian
effect of wheelchair handrail compensator and rehabilitation training for patients with hemiplegic shoulder pain

Conditions: Shoulder Pain

Summary: the purpose of this study is to determine whether wheelchair handrail compensator plus rehabilitation training could do better than ordinary wheelchair plus rehabilitation training in relieving pain and improving daily life activity, upper limb motor function and quality of life for patients with hemiplegic shoulder pain.

the ideal management of hemiplegic shoulder pain(hsp) is prevention,and a normal limb position is necessary for preventing and reducing hemiplegic shoulder pain.the foam or board supports has been used to prevent shoulder pain and could be recommended for wheelchair users to keep normal position. therefore, the investigators designed the equipment wheelchair handrail compensator and expected to help paralyzed limbs to maintain a normal position.using of the wheelchair handrail compensator may help patients achieve: pain relieve, improvement of upper limb function and increase of the quality of life.the aim of this study was to evaluate the effect of treatment by wheelchair handrail compensator and rehabilitation training for people with hemiplegic shoulder pain.

Eligibility criteria:
inclusion criteria: * specific diagnosis refer to the "china guideline for cerebrovascular disease prevention and treatment" * course of disease range from two weeks to six months * age range from 20 to 85 years old * brunnstrom scale range from i to ii * good mental status and could be able to answer questions exclusion criteria: * patients with brain trauma, thalamic lesions or peripheral neuropathy * patients with a history of cervical spondylosis, periarthritis, fracture or trauma at the shoulder, osteoporosis or myocardial infarction which could cause shoulder pain * patients get worse as a result of cerebral edema or coma following stroke * patients with serious infection or disorder in heart, liver and kidney * patients withdraw from the research by themselves

Keywords: hemiplegia shoulder pain wheelchair stroke rehabilitation
the european prospective investigation into cancer in norfolk prospective population study

Conditions: Neoplasms; Cardiovascular Diseases; Death

Summary: the european prospective investigation into cancer and nutrition in norfolk is a population based prospective study of approximately 25,000 men and women resident in norfolk united kingdom. they were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. while part of a ten country half million participant european collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease.

the european prospective investigation into cancer and nutrition in norfolk is a population based prospective study of approximately 25,000 men and women resident in norfolk united kingdom. they were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. while part of a ten country half million participant european collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease. detailed data on sociodemographic, lifestyle, medical and family history were collected and a biological sample bank including urine and blood samples established. participants have been followed up through repeat examinations, mailed questionnaires as well as through record linkage with routine health records including death certification by cause, cancer registration and hospital admissions by cause till present.

Eligibility criteria:
inclusion criteria: * willing to participate * on general practice age sex registers in norfolk, united kingdom in 1993-1997 exclusion criteria: * not willing to participate in study * terminal illness

Keywords: nutrition physical activity lifestyle smoking
a clinical trial to find out v81444's side effects and blood levels in healthy men

Conditions: Parkinson's Disease

Summary: a double-blind, randomised, placebo-controlled study of the safety, tolerability and pharmacokinetics of single and multiple ascending oral doses of v81444 in healthy male volunteers

part a - single ascending dose (sad) double-blind, randomised, placebo-controlled, single ascending dose study. each study subject will participate in a screen visit, three identical treatment periods, in each of which they will receive a single oral dose of v81444 or placebo in accord-ance with the randomisation schedule, and one post-study visit. in each treatment period, subjects will be admitted the day before dosing (day -1) and, subject to satisfactory medical review, discharged in the morning, 4 days later (day 4). part b - multiple ascending dose (mad) double-blind, randomised, placebo-controlled, parallel group, multiple ascending dose study each study subject will participate in a screen visit, one treatment period in which they will receive repeated oral doses of v81444 or placebo in accordance with the randomisation schedule, and one post-study visit. in each treatment period, subjects will be admitted the day before dosing (day -1), dosed daily on days 1 to 14 and, subject to satisfactory medical review, will be discharged in the morning, 3 days after the final dose (day 17).

Eligibility criteria:
inclusion criteria: * healthy male volunteers: aged 18 to 45 years, in good general health as determined by medical history, physical examination and screening investigations, and taking no regular medication. confirmation to be sought for all volunteers that their general practitioner has provided an acceptable medical history. exclusion criteria: * have a history or evidence of clinically significant gastrointestinal disease, including ulcers, gastro-oesophageal reflux disease or gastritis * any known malformations that would make ogd difficult or unsafe(part b only) * have taken v81444 in any previous investigational study * have taken any restricted concomitant medication * have multiple drug allergies or be allergic to any of the components of v81444 study medication or its matching placebo or midazolam (part b only) * in the 4 calendar months before study drug administration have smoked more than 5 cigarettes per day have consumed more than 28 units of alcohol per week have donated blood or plasma in excess of 500 ml been exposed to any new investigational agent or any other adenosine a2a receptor antagonist used non-steroidal anti-inflammatory drugs regularly had a new tattoo or body piercing * have any clinically relevant abnormal findings at screening and/or admission * intend to father a child with their female partner or through sperm donation within 4 months after the last dose of study medication
efficacy of sealing molars: split-mouth randomized clinical trial

Conditions: Dental Caries

Summary: the sealing of fossae and fissures is an effective procedure in preventing occlusal caries lesions. however, there are gaps regarding its efficacy in the treatment of initial enamel lesions. in addition, there are no studies in the literature that have compared the longevity of sealings performed with the different sealants available in the market. thus, the objective of this study is to evaluate the efficacy of fossae and fissures sealings performed with a low-cost resinous sealant in occlusal lesions in enamel in permanent and deciduous molars. this is a multicenter clinical study of non-inferiority, randomized, controlled, double blind (patient and operator) with 60 deciduous molars and 340 permanent molars of children 4 and 9 years of age. the sample unit will be the tooth, which will be randomized into two groups using a distributed randomization list in mixed envelopes that will be open only at the time of the procedure. the teeth allocated in the test group will be treated with the sealant preventâ; those allocated in the control group will employ the fluroshieldâ sealant. in both groups the procedure will follow the manufacturer's standards. the efficacy of the sealant will be evaluated by means of clinical and radiographic control at 6, 12 and 18 months after the procedure. secondary outcomes, such as retention, cost, acceptability and quality of life, will also be evaluated.


Eligibility criteria:
inclusion criteria: * children with at least two deciduous and/or permanent molars with occlusal caries lesions scores 1, 2 or 3 of the icdas (ismail et al., 2007) will be included, one on each side, preferably from the same arch. exclusion criteria: * patients with special needs; * using orthodontic appliances; * with systemic diseases; * teeth that present restorations, sealants, formation defects, deep caries lesions that may lead to pulp impairment; * teeth with fistula and/or abscess; * teeth with spontaneous painful symptomatology.

Keywords: dental caries molars pit and fissure sealants
antithymocyte globulin in treating patients undergoing stem cell transplant for multiple myeloma

Conditions: Multiple Myeloma and Plasma Cell Neoplasm

Summary: rationale: biological therapies, such as antithymocyte globulin, may stimulate the immune system in different ways and stop cancer cells from growing. purpose: this phase ii trial is studying how well antithymocyte globulin works in treating patients undergoing stem cell transplant for multiple myeloma.

objectives: primary * determine the response rate at 4 weeks in patients with multiple myeloma treated with anti-thymocyte globulin at least 4 to 6 weeks prior to undergoing conditioning therapy for allogeneic or autologous stem cell transplantation. secondary * determine the toxicity of this drug, in terms of formation of antirabbit antibodies, in these patients. outline: this is an open-label, multicenter study. patients receive anti-thymocyte globulin iv over 6 hours on day 1 and over 4 hours on days 3 and 5. treatment begins 4 to 6 weeks prior to undergoing conditioning therapy for autologous or allogeneic stem cell transplantation. after completion of study treatment, patients are followed at 28 days. projected accrual: a total of 12 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: * histologically confirmed multiple myeloma * candidate for autologous or allogeneic stem cell transplantation within 1 to 3 months after study treatment * measurable disease, defined as serum monoclonal protein ≥ 1 g/dl or urinary light chain excretion = 500 mg/24 hours * no malignant cns disease patient characteristics: * life expectancy ≥ 6 months * absolute neutrophil count ≥ 1,000/mm³ * platelet count \> 50,000/mm³ * creatinine ≤ 2 mg/dl * hepatic function ≤ 2 times upper limit of normal * dlco ≥ 50% * no active infection * no hypersensitivity to rabbit proteins * no symptomatic hyperviscosity syndrome * negative pregnancy test prior concurrent therapy: * more than 28 days since prior chemotherapy, including prednisone (20 mg equivalent/day) * no prior anti-thymocyte globulin * no concurrent radiotherapy

Keywords: stage i multiple myeloma stage ii multiple myeloma stage iii multiple myeloma refractory multiple myeloma
atrial fibrillation after catheter versus thoracoscopic ablation using patient activated implantable loop recorders: the actual study

Conditions: Atrial Fibrillation

Summary: atrial fibrillation (af) is a common but often distressing condition. it can be treated with medications, but these are not always effective or tolerated. ablation is a well-recognised technique that is recommended for those with symptomatic af who have failed medical therapy. ablation can be performed in a number of ways. in percutaneous ablation, ablation is performed via tiny punctures in the skin in the groin. in minimally-invasive thoracoscopic ablation, ablation is performed under general anaesthetic via very small incisions in the chest wall. because af can be intermittent, the only reliable way to look for it is with long-term ecg monitoring. a safe and practical way to do this is to use implantable loop recorders (ilrs). in this study, the investigators are trying to see if minimally-invasive thoracoscopic ablation is better than percutaneous ablation, and in turn if they are better than direct current cardioversion (dccv), using ilrs to monitor af.


Eligibility criteria:
inclusion criteria: * symptomatic persistent atrial fibrillation * age over 18 years * informed consent exclusion criteria: * pre-existing ilrs or permanent pacemakers that do not allow for continuous monitoring for af occurrence, or are not mri safe. * patients unable to undergo general anaesthesia for af ablation. * previous cardiac surgery, such as coronary artery bypass grafting or valvular surgery * previous thoracic surgery * participation in a conflicting study * participants who are mentally incapacitated and cannot consent or comply with follow-up * pregnancy * other cardiac rhythm disorders

Keywords: atrial fibrillation ablation percutaneous ablation minimally-invasive thoracoscopic ablation implantable loop recorder
the effect of low level tragus stimulation on the electrophysiological substrate of patients with ischemic cardiomyopathy substrate of subjects with ischemic cardiomyopathy

Conditions: Ischemic Cardiomyopathy

Summary: patients with ischemic cardiomyopathy (left ventricular ejection fraction \<35%) and heart failure who already have an implantable device with an atrial lead (dual chamber defibrillator or biventricular defibrillator) will undergo sequentially 1. sham low level tragus stimulation (llts) (5min), 2. active llts at 5hz (15min) and 20hz (15min) and 3. active llts group with atrial pacing at 100bpm at 5hz (15min) and 20hz (15min). the latter is required to examine the effect of llts on ra independent of heart rate. repolarization alternans will be measured by analyzing a regular 12-lead ecg using a custom-made software.


Eligibility criteria:
inclusion criteria: 1. ischemic cardiomyopathy (lvef \<35%) and heart failure 2. implantable device with an atrial lead (dual chamber icd or crt-d) 3. sinus rhythm at the time of the study exclusion criteria: 1. recent (\<6 months) stroke or myocardial infarction 2. persistent atrial fibrillation 3. recurrent vaso-vagal syncopal episodes 4. unilateral or bilateral vagotomy 5. pregnancy or breast feeding 6. uncontrolled diabetes or hypertension 7. sick sinus syndrome and 2nd or 3rd degree av block (without a pacemaker) 8. bifascicular block or prolonged first degree block 9. hypotension due to autonomic dysfunction 10. inability or unwillingness to understand and/or sign informed consent

Keywords: ischemic cardiomyopathy; neuromodulation; repolarization alternans
comparison of loading dose magnesium sulphate with prichard regimen in the management of severe preeclampsia and eclampsia.

Conditions: Severe Pre-eclampsia; Eclampsia

Summary: preeclampsia/eclampsia is part of a spectrum of multi-systemic pregnancy disorder that contributes substantially to maternal and perinatal morbidity and mortality, especially in low resource setting. this study was done in abakaliki, ebonyi state, southeast nigeria. to compare the efficacy of loading dose of magnesium sulphate with that of the pritchard regimen in the prevention of eclampsia in severe preeclampsia and recurrent fits in eclampsia in a low resource setting. a prospective, single blinded randomized controlled study of loading dose versus pritchard regimens of mgso4 at the teaching hospital abakaliki. one hundred and twenty patients were recruited 60 to each arm using computer-generated numbers. sociodemographic characteristics, efficacy and adverse effects of the drug on the mother and baby were noted.

background: preeclampsia/eclampsia is part of a spectrum of multi-systemic pregnancy disorder that contributes substantially to maternal and perinatal morbidity and mortality, especially in low resource setting. this study was done in abakaliki, ebonyi state, southeast nigeria. objectives: to compare the efficacy of loading dose of magnesium sulphate with that of the pritchard regimen in the prevention of eclampsia in patients with severe preeclampsia and recurrent fits in eclampsia in a low resource setting like ours. methods: this was a prospective, single blinded randomized controlled study of loading dose versus pritchard regimens of mgso4 at alex ekwueme federal university teaching hospital abakaliki. one hundred and twenty patients were recruited 60 to each arm using computer-generated numbers. social demographic characteristics, efficacy and adverse effects of the drug on the mother and baby were noted. data were collated, tabulated and analyzed using the statistical package for social sciences (spss) software (version 22, chicago ii, usa)

Eligibility criteria:
inclusion criteria: * pregnant women with severe preeclampsia * pregnant women with eclampsia * signing of informed consented to participate in the study. exclusion criteria: * refusal of consent, * gestational age \< 28 weeks * received magnesium sulphate prior to presentation * mild preeclampsia * chronic hypertension in pregnancy * medical or obstetrical complication of pregnancy.

Keywords: pre-eclampsia eclampsia magnesium sulphate