Kornimate/medical-research-clean huggingface dataset:
analysis of body balance parameters in children with idiopathic scoliosis

Conditions: Idiopathic Scoliosis

Summary: the aim of the study is to compare body balance parameters assessed using the amti dynamometric platform in children with idiopathic scoliosis (with and without schroth therapy) compared to control group.

assessment of balance parameters on the amti dynanometric platform in children with adolescent idiopathic scoliosis and healthy children in the same age group. each person examined will have one trial measurement, followed by a 3-minute break. after the trial measurement, the actual examination will take place - 3 trials of 60 seconds each in 4 different variants: eyes open, eyes closed, single leg left lower limb eyes open, single leg right lower limb eyes open.the variants will be randomized. assessment of body posture using photo recordings taken with an olympus digital camera, which will be used to classify the type of scoliosis. anthropometric points will be marked using a washable marker: cervical-thoracic junction c7-th1, thoracic-lumbar junction th12/l1, lumbosacral junction l5/s1, right and left anterior superior iliac spine (asis), right and left posterior superior iliac spine ( psis), the center of the right and left greater trochanters and the center of the lateral malleolus. photo registration will be made in four positions: front, back, right side and left side. the camera is 3 m away from the subject and the height of the tripod is half the height of the body. analysis of spine x-ray images: cobb angle, schroth type of scoliosis, bordering vertebrae, apex vertebra, vertebral rotation, sagittal plane analysis

Eligibility criteria:
inclusion criteria: * idiopathic adolescent scoliosis aged 10-18 years, female, * control group aged 10-18 years, female. exclusion criteria: * congenital spine defects, * spine surgeries, * neurological diseases, * cardiological diseases, * genetic diseases, * rheumatological diseases, * immunological diseases, * endocrine diseases * back pain, * lower limb pain, * past injuries of lower limbs or spine

Keywords: spinal deformity amti platform balance postural stability
the test of those managing pain with their own pain

Conditions: Empathy

Summary: the study aims primarily to investigate physicians' awareness of their health status, empathy towards patients, and management processes through a questionnaire targeting physicians who diagnose and manage patients' pain.


Eligibility criteria:
inclusion criteria: * specialist physicians actively working in pain treatment and management (e.g., algology, physical medicine and rehabilitation, anesthesiology, neurology, rheumatology, etc.) or physicians currently undergoing specialty training in these areas. * physicians who volunteer to participate in the study and sign the informed consent form. * physicians who have actively followed up patients and applied pain management techniques within the last year. exclusion criteria: * physicians who are not actively involved in pain management or who specialize in different medical fields. * physicians who do not wish to complete the questionnaire or do not provide voluntary consent. * physicians who complete the questionnaire incompletely or invalidly during the study.
red blood cell atp release and vascular function in humans

Conditions: Cardiovascular Diseases

Summary: previous work demonstrates that the red blood cells of older adults do not release a potent vasodilator (atp) as well as the red blood cells of younger adults. the investigators are targeting a pathway within the red blood cell using fasudil hydrochloride to determine if both the release of atp from red blood cells and blood flow responses to low oxygen (hypoxia) and exercise in older adults can be improved.

participants will initiate contact with the investigators by responding to flyers placed in the community either by phone or email. the first correspondence (phone or email) will provide a brief description of the research and ask a series of screening questions to determine age, height, weight, and any medications participants may be taking as well as the current health status (diagnoses, basic health history, and physical activity level) of participants. if they qualify, a two hour screening visit is scheduled during a time when the participant will be examined by the physician. all participants will undergo informed consent in a face to face private meeting with the research coordinator. following informed consent, participants will be evaluated by a physician and undergo a treadmill stress test to rule out cardiovascular disease. during the study, heart rate will be monitored with a 3-lead ecg and blood pressure will be monitored noninvasively with a blood pressure cuff on the finger (finometry). venous blood will be collected at multiple time points via a catheter inserted into a forearm vein draining skeletal muscle circulation for measurement of blood gases (0.5 ml/sample) and plasma \[atp\] (2 ml/sample), with less than 100 ml of blood being drawn in total (\~60ml total). blood flow at rest and in response to hypoxia and exercise will be measured non-invasively using doppler ultrasound of the brachial artery. hypoxia trials will be performed by having participants breathe a low oxygen gas mixture via a mouthpiece that is hooked up to gas tanks and an anesthesia monitor to decrease their oxygen saturation to \~80% (similar to hiking a 14er) for 10 minutes. exercise trials will last for approximately 15 minutes and will involve participants performing graded-intensity rhythmic handgrip exercise by lifting weights (corresponding to a low, moderate, and high workload) using a pulley system. the drug treatment used in this study (fasudil) is being given because it may improve red blood cell atp release in older adults. this is a double-blinded placebo controlled study, thus participation will occur on two randomized experimental days.

Eligibility criteria:
inclusion criteria: * healthy * sedentary to moderately active * 18 to 30 years old for young subjects * 60 to 80 years old for older subjects exclusion criteria: * obesity (bmi ≥ 30 kg/m\^2) * cardiovascular disease * metabolic disease * use of medications that can influence cardiovascular function * blood pressure greater than or equal to 140/90 * smoker * use of hormone replacement therapy
early versus delayed intubation of patients with covid-19

Conditions: COVID-19; Acute Hypoxemic Respiratory Failure

Summary: although management of acute hypoxemic respiratory failure associated with coronavirus disease 2019 (covid-19) often includes mechanical ventilation, the optimal timing of initiation of invasive mechanical ventilation remains unknown. we hypothesise that a randomized controlled trial comparing early intubation as opposed to delayed intubation among patients with covid-19 suffering from severe acute hypoxemic respiratory failure is feasible.

a common manifestation of covid-19 is severe acute hypoxemic respiratory failure. management of acute hypoxemic respiratory failure associated with covid-19 often includes mechanical ventilation. the optimal timing of initiation of invasive mechanical ventilation remains unknown. on the one hand, early initiation of invasive mechanical ventilation (i.e. early endotracheal intubation) has been advocated as a means to reduce subsequent possible aerosolization of the virus, as would happen by alternate means of oxygenation/ventilation allowing air leaks. also, early intubation may prevent the induction of self-inflicted lung injury in patients who breath spontaneously and have high respiratory drive and, therefore, large transpulmonary pressure swings. on the other hand, delaying intubation, by trying alternate means of oxygenation/ventilation, may mean that some of the patients may not be intubated at all and therefore will be protected from the adverse events of invasive mechanical ventilation (such as ventilator-induced lung injury, ventilator-associated pneumonia and ventilator-induced diaphragmatic dysfunction). the latter strategy may also address the unavailability of enough ventilators to meet the increased demand of treating patients with covid-19. given that no randomized controlled trials are currently available to guide clinical practice regarding optimal timing of intubation, we propose a single-center randomized controlled feasibility trial to compare early intubation versus delayed intubation among patients with covid-19 suffering from severe acute hypoxemic respiratory failure. the aim is that we gain experience and produce pilot data, which could inform the design of a subsequent large multi-center clinical trial.

Eligibility criteria:
inclusion criteria: adult patients with confirmed covid-19 and severe acute hypoxemic respiratory failure exclusion criteria: * postoperative acute respiratory failure (within one week from surgery) * after cardiac arrest * chronic hypoxemic respiratory failure * hypercapnic respiratory failure * no full code * lack of equipoise of the clinical team * lack of informed consent

Keywords: covid-19
study of muromonab-cd3 and cyclosporine in patients with giant cell myocarditis

Conditions: Myocarditis

Summary: this is a study to determine the efficacy of muromonab-cd3 and cyclosporine as treatment in patients with giant cell myocarditis (gcm). t lymphocytes appear to be involved in gcm. muromonab-cd3 has been shown to reduce the number of lymphocytes and cyclosporine inhibits lymphocyte activation. this treatment may prolong patient survival until transplantation or ventricular assist device placement is possible.

each patient will be randomized to receive either standard care and immunosuppression therapy (treatment group) or standard care alone (control group). to prevent bias, randomization will be stratified by recency of symptom onset to ensure that both the treatment and control groups are balanced with respect to it. within each of these 2 strata, permuted-block randomization will be done to keep the number of treatment and control patients balanced. due to the necessary monitoring of the patients randomized to receive immunosuppression therapy, treatment cannot be blinded. approximately 1 year after the last patient has been randomized, the observed times from randomization to the composite endpoint (death, transplantation, or lvd placement) will be compared in the treatment and control groups. completion date provided represents the completion date of the grant per oopd records

Eligibility criteria:
inclusion criteria: * idiopathic heart failure and/or arrhythmia of less than 3 months duration * endomyocardial biopsy diagnostic of idiopathic giant cell myocarditis * negative pregnancy test exclusion criteria: * clinical evidence of sepsis or active infection (e.g., meningitis or osteomyelitis) * pregnant * any contraindication to immunosuppression * allergy to cyclosporine or muromonab-cd3 * creatinine greater than 2.5 mg/dl * ast or alt greater than 3 times upper limit of normal * other severe concurrent disease that would preclude study * unreliable or uncooperative subject

Keywords: giant cell myocarditis
prospective metabolic surgery in t2dm chinese subjects

Conditions: Diabetes; Obesity

Summary: the primary goal of this study is to assess impact of metabolic surgery on glycemic control in diabetic patients.

the primary objective of this study is to assess the impact of metabolic surgery (roux-en-y gastric bypass \[rygb\] or sleeve gastrectomy \[sg\]) on composite measure of glycemic control at 2 years post surgery in a type 2 diabetes mellitus (t2dm) cohort of subjects.

Eligibility criteria:
inclusion criteria: 1. 20 to 60 years of age (inclusive) on the date the informed consent document (icd) is signed; 2. a body mass index (bmi) from 28 kg/m2 to 50 kg/m2 ; 3. previously diagnosed for at least 6 months with t2dm according to world health organization (who) criteria; 4. c-peptide \> 1 ng/ml (0.3 nmol/l); 5. able and willing to comply with procedures required by the protocol; and 6. able to comprehend and sign or, if illiterate, leave their thumb impression on the study icd. exclusion criteria: 1. history of t2dm for a duration \> 10 years; 2. history of drug and/or alcohol abuse within 2 years of screening visit; 3. any previous major gi surgery (e.g., any gi surgery with a resection, etc.). previous gi surgery allowed include: appendectomy, gall bladder surgery, liver biopsies, and endoscopic procedures; 4. scheduled concurrent surgical, non-endoscopy, procedure from visit 1 through the end of visit 3; 5. women of childbearing potential who are pregnant or lactating at the time of screening, at the time of surgery, or planning to become pregnant one year or sooner after the surgery; 6. psychiatric disorders that may affect compliance with the clinical study, including dementia, active psychosis, severe depression, or history of suicide attempts; 7. any of the following conditions: 1. inflammatory diseases of the gi tract, including severe intractable esophagitis, gastric ulceration, duodenal ulceration, or specific inflammation such as crohn's disease or ulcerative colitis that have been active within the past 10 years; 2. end stage renal disease; 3. abnormal results from glutamic acid decarboxylase autoantibodies (gada) or protein tyrosine phosphatase-like protein (ia-2a) testing; or 4. immunocompromised such as that resulting from chronic oral steroid use, cancer chemotherapeutic agents, or immune deficiency disorders; 8. participation in any other clinical study (not to include registries or survey-only studies) within 30-days or 5 half-lives of an investigational drug (which ever is longer), of visit 1 (screening visit) and for the duration of the study.
incidence of respiratory depression in cesarean section

Conditions: Respiratory Depression; Postoperative Pain

Summary: this study is designed to determine the incidence and severity of respiratory depression in elective cesarean section patients who have received a spinal or epidural narcotic called duramorph for management of postoperative pain. a monitoring device called a capnograph as well as a device called a pulse oximeter is placed on the patient once in the recovery room after delivery. the capnograph monitors the carbon dioxide level that the patient breathes out as well as their respiratory rate. the pulse oximeter is a device that is taped on the patient's finger and measures their oxygen saturation level. the monitoring is maintained for 18-24 hours after surgery.


Eligibility criteria:
inclusion criteria: * are female \>= 18 years of age and \<=55 years of age with asa class i-iii * schedule for cesarean surgery * are willing and able to sign informed consent form for this study * are willing and able to follow the instruction in this study protocol exclusion criteria: * have known contraindication/allergy to neuraxial anesthesia or morphine. * have an asa class \> iii * age \> 55 years

Keywords: postoperative pain management respiratory depression capnography duramorph
bupropion for fatigue in end-stage kidney disease patients on hemodialysis

Conditions: End Stage Renal Disease; Fatigue

Summary: fatigue is the most common symptom reported by end-stage kidney disease patients on maintenance hemodialysis. unfortunately, there currently is no medical management for this overwhelming feeling of tiredness. as a result, patients continue to suffer with poor quality of life and impaired daily activities. the purpose of this pilot trial is to find out if bupropion (a medicine commonly prescribed for stopping smoking, seasonal mood disorder, and depression) may help lessen fatigue in hemodialysis patients. in this study, hemodialysis participants will receive bupropion tablet orally three times a week during routine dialysis procedure for consecutive 8 weeks. study participants will complete a battery of questionnaires to self-report fatigue, cognition, and quality of life. the study team will collect biological specimens. all these procedures will be performed at the dialysis clinic during routine dialysis procedure.

while taking part in this study, participants will be asked to complete study procedures with the researchers or study staff three times a week during routine dialysis visits. collections of blood, urine (if available) and stool will be collected at different time points over the 8-week intervention. blood will be analyzed for markers of inflammation, amino acids, and for safety labs as needed. blood will also be tested for pharmacokinetics of bupropion. primary objective: to evaluate the feasibility and efficacy of bupropion for the treatment of fatigue in patients with end-stage kidney disease on maintenance hemodialysis. secondary objective: to evaluate the effect of bupropion in reducing inflammatory markers in hemodialysis patients with fatigue. exploratory objective: to examine whether bupropion improves cognitive function.

Eligibility criteria:
inclusion criteria: 1. male and female eskd patients between aged 25-74 yrs on maintenance in-center hemodialysis procedure 3 times/week for ≥3 months with an arteriovenous fistula or graft. 2. blood hemoglobin of ≥10.0 g/dl based on most recent routine laboratory profile. 3. dialysis adequacy measured with kt/v of ≥1.2 4. ability to understand and the willingness to sign a written informed consent document exclusion criteria: 1. currently on bupropion or hypersensitivity/ intolerance to bupropion by history and monoamine oxidase inhibitors. 2. diagnosis or history of eating disorders (bulimia or anorexia nervosa) and seizure. 3. pregnant, lactating, childbearing women 4. history of post-acute covid-19 syndrome 5. diagnosis of depression and/or on antidepressants and bipolar affective disorder 6. patient health questionnaire (phq)-9 score of ≥10 7. diagnosis of cognitive impairment including dementia 8. current participation in another interventional trial 9. scheduled for kidney transplantation in next 6 months 10. life expectancy \<6 months as judged by the attending nephrologist/primary care physician. 11. current or history of substance abuse or dependency.

Keywords: hemodialysis kidney dialysis
the management of surgical scars around knee after pediatric orthopedic surgery: an observational, case-control study

Conditions: Surgical Scar

Summary: scar is an unpleasant symptom that commonly appear after orthopedic surgery, especially the joint procedure. due to the wide motion range, skin around joint has excessive tension that may increase risk for wide or conspicuous scar formation of surgical wound. noticeable scar can negatively impact the quality of life and psychosocial development. however, scar management is overlooked in early recovery period easily. patients commonly start to turn their attention to the surgical scar after the completion of rehabilitation or the resolution of disease or unbearable symptom. it is always beyond the best period of scar treatment, 3 to 6 months after wound healing. this study is aimed to observe and evaluate the scar formation with or without aggressive management in pediatric population within 6 months after wound healing.

this is an observational, case-control study. patients will be invited to participate and allocated to scar dressing group if they plan to use scar dressing. after gaining the written inform consent, participants will be asked to fulfill the patient diary, including the record of scar dressing use, patient scar assessment scale and satisfaction assessment, with parents' help. in regular group, patients are retrospectively selected by matched factors, such as demographics data. scar-related data, including scar pictures, vancouver scar scale assessment and complication, are collected from medical history in both groups.

Eligibility criteria:
inclusion criteria: 1. aged 5 to 18 years 2. had orthopedic surgery 3 weeks ago and within 6 weeks 3. had incision sites around the knee 4. all surgical wounds healed completely 5. length of surgical wounds between 2 and 15 centimeters 6. planed to treat incisional scar with scar dressing, adhesive tapes, or adhesive strips exclusion criteria: 1. surgical wound infection 2. atopic dermatitis or sensitive skin 3. not able to make return visits regularly 4. participation was not appropriate determined by physician

Keywords: scar-care surgical wound incision site cicatrix fibrosis knee pediatric orthopedic procedures
integrated mindfulness for provoked vestibulodynia

Conditions: Provoked Vestibulodynia

Summary: this study aims to test the efficacy of a 4-session intervention (group psychoeducational treatment) using a randomized study design. participants will be randomized in to 'immediate treatment' or 'waitlist control'. women in the wait-list condition will receive the 4-session improved treatment, just as women randomized to the experimental group, after the end of their wait-list period.


Eligibility criteria:
inclusion criteria: * must be a patient at the british columbia centre for sexual medicine * diagnosis of provoked vestibulodynia (pvd) * 19 years of age or older * premenopausal * fluent in english exclusion criteria: * not at patient at the bc centre for sexual medicine * unprovoked vulvar pain, other pathology causing pain with penetration, or chronic pelvic pain * being uncomfortable and unwilling to participate in a group setting.

Keywords: provoked vestibulodynia dyspareunia vulvodynia mindfulness cognitive behavioural therapy
study of psycho-social impact of keloid

Conditions: Keloid

Summary: despite their benign nature, keloids may constitute a severe aesthetic, and in some cases, functional problem which translates to various repercussions on person's quality of life, including much stress and insecurities. keloids are mostly observed between the ages of 10 and 30. although keloid is a common condition and the investigators can make assumptions about those living with keloids, the investigators do not know the actual impact of the illness on the overall performance of patients' and how this disease, day to day, is impacting their lives. the investigators are conducting this study, aimed to investigate the psychosocial impact of keloid on daily life. information is collected anonymously. you must be 18 years of age or older to take this survey. parents can respond on behalf of their children who are not 18 years of age yet. the online survey will take 20-30 minutes to complete.


Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of keloid 2. informed consent 3. age above 18 to answer the survey questions 4. parents shall respond on behalf of their minor children

Keywords: keloid
the effect of nursing care program on women with endometriosis

Conditions: Endometriosis; Quality of Life; Healthy Life Style

Summary: this study was carried out to determine the effect of the endometriosis nursing care program (encp) given to women with endometriosis in line with the health promotion model, on the quality of life and healthy lifestyle behaviors of women.

this experimental study, which was conducted in a single-blind, with control group, prospective, randomized type in the first test-post-test order, was carried out in the endometriosis polyclinic of istanbul zeynep kamil gynecology and pediatrics training and research hospital. in the preliminary evaluation, 46 women with endometriosis health profile questionnaire-5 (ehp-5) scores of 22 and above (50 and above in the 100 system) constituted the sample of the study, including 23 intervention and 23 control groups. while the nursing care program for women with endometriosis (ncpe) was applied to the intervention group, only routine care was applied to the control group. introductory information form, ehp-5, healthy lifestyle behaviors scale ii (hlbsii), and satisfaction questionnaire for ncpe were used as data collection forms in the study.

Eligibility criteria:
inclusion criteria: * having been diagnosed with endometriosis, * being in the reproductive period, * no communication barrier, * not having been diagnosed with a psychiatric illness, exclusion criteria: * getting pregnant during the study, * it was determined as wanting to leave the study,

Keywords: endometriosis, health promotion model, nursing care