Kornimate/medical-research-clean huggingface dataset:
resilience and acute stress in simulation

Conditions: Stress, Professional; Resilience; Anaesthesiology; Simulation

Summary: the objective is to study an association between the resilience developed by anesthesia professionals and the level of acute stress during a simulation session.

this trial will take place at the grenoble alpes university hospital. volunteer anaesthetists, nurse anaesthetists, professionals or students will perform a simulation scenario. this scenario generates a high level of stress and focuses on medication errors, which is a good educational tool for the participants. the simulation is performed in an available operating room with a dedicated anesthesia cart. in this environment, 17 error opportunities were created, i.e., factors that could contribute to the occurrence of a medication error. a person playing the role of the anesthesiologist will give instructions, leave the room, and return to interrupt the participant several times, which will contribute to the intensity of the stressor. the simulation will proceed as follows: briefing: welcome and explanation of the session. collection of age, gender, number of years in anesthesia, number of previous simulation sessions, participation or not in stress management training. presentation of the context and the anesthesiologist, then the participants evaluate their stress using the vas (visual analog scale) stress, which triggers the beginning of the scenario. introduction of the setting and the anesthesiologist, then participants rate their stress using the vas stress scale, triggering the start of the scenario. scenario: 10 minutes in length. after the briefing, the anesthesiologist announces the imminent arrival of a patient with a suspected abdominal aortic aneurysm. the participant must quickly prepare a tray of medications. the scenario ends just prior to the patient's arrival, with the anesthesiologist presenting the stress vas again for further evaluation. debriefing: the participant completes a questionnaire about opportunities for detected errors, followed by a 15-minute debriefing after the simulation session. for each participant, data regarding stress vas, cd-risc, pss-10 and number of errors detected will be compared. the primary objective is to analyze an association between resilience developed by anesthesia professionals and acute stress level. the secondary objectives are to study the association between the resilience developed by the anesthesia professionals and the level of acute stress present immediately at the end of the simulation. immediately at the end of the simulation. measure the association between resilience (cdrisc 10) and performance (number of potential errors detected). compare resilience and acute stress between different statuses (anesthesiologist, intern, nurse anesthetist, student nurse anesthetist).

Eligibility criteria:
inclusion criteria: * accepts healthy volunteers exclusion criteria: * participants who object to the use of their data for research purposes.
sglt2 inhibition and stimulation of endogenous glucose production: protocol 2

Conditions: Type II Diabetes Mellitus

Summary: in protocol 2, the investigators will determine the role of pancreatic hormones (increase in plasma glucagon and decrease in plasma insulin concentration) in the stimulation of egp following sglt2 inhibition.

the inhibition of the renal (kidney) sglt2 transporter has proven to be an effective therapeutic intervention to reduce plasma glucose levels (amount of glucose found in the liquid part of blood) and hba1c. in this study, the investigators hope to define the role of increased plasma glucagon, decline in plasma insulin, and fall in plasma glucose concentration. the investigators will examine whether the signal for the increase in egp (endogenous glucose production) caused by glucosuria (an excess of sugar in the urine, typically associated with diabetes) is mediated via the decrease in plasma glucose and insulin concentrations, or by the increase in plasma glucagon concentration.

Eligibility criteria:
inclusion criteria: * t2dm subjects * 18 - 70 yrs old * bmi = 25-45 kg/m2 * must be on a stable dose (more than 3 months) of monotherapy or combination therapy with metformin and/or a sulfonylurea * hba1c \<10.0% * stable body weight (± 3 lbs) over preceding 3 months * do not participate in excessively heavy exercise exclusion criteria: * subjects taking drugs known to affect glucose metabolism (other than metformin and sulfonylurea) * individuals with evidence of proliferative diabetic retinopathy, plasma creatinine \>1.4 females or \>1.5 males, or 24-hour urine albumin excretion \> 300 mg
troponin release induced by procedure - czech

Conditions: Coronary Artery Disease

Summary: a prospective study aiming to analyse the relation between different variables and high sensitivity troponin i (hstni) elevation within a group of patients undergoing a coronary angiography with or without subsequent percutaneous coronary intervention.

the study tries to seek potential causes and context of subclinical myocardial injury within patients with baseline concentration of hstni below the 99th percentile value upper reference limit or with demonstrated fall of hstni levels.

Eligibility criteria:
inclusion criteria: * stable or unknown coronary artery disease * acute coronary syndrome without st-segment elevation meeting the criteria of low risk with demonstrated fall of ctn levels exclusion criteria: * acute coronary syndrome with persistent st-segment elevation * acute coronary syndrome without st-segment elevation meeting the criteria of high or intermediate risk

Keywords: myocardial injury high-sensitivity troponin i periprocedural myocardial infarction
explanted liver and ex-vivo pancreatic specimen evaluation by 7 tesla mri

Conditions: Liver Cirrhosis; Liver Steatosis; Hepatocellular Carcinoma; Pancreatic Cancer; Magnetic Resonance Imaging

Summary: aim of this study is to evaluate the correlation between the characteristics detected by the 7t mri equipment and the histological composition of native explanted livers (group a), liver graft excluded for donation (group b) and surgical specimens of primary pancreatic tumour, which underwent pancreaticoduodenectomy (group c).


Eligibility criteria:
group a of native liver inclusion criteria: * informed consent * full possession of one's faculties * patients who are going to undergo liver transplantation, independently from previous therapy or from the primary disease they are affected by. exclusion criteria: * patients affected by polycystic liver disease * excluded from liver transplantation. group b of excluded grafts inclusion criteria: - liver grafts with histologically proven macrovescic steatosis, not fit for transplantation exclusion criteria: * liver grafts histologically proven macrovescic steatosis fit for transplantation * liver grafts not fit for transplantation due to causes other than steatosis group c of focal pancreatic lesion inclusion criteria: * informed consent * full possession of one's faculties * pancreatic lesion assessed by ct examination and histologically proved, which are candidates for pancreaticoduodenectomy or total pancreatectomy exclusion criteria: - excluded from surgery due to the severity of their condition.

Keywords: liver cirrhosis steatosis hepatocellular carcinoma pancreatic cancer 7 tesla magnetic resonance imaging
a phase ii study of docetaxel and carboplatin in late relapse of ovarian cancer

Conditions: Ovarian Epithelial Cancer Recurrent

Summary: a phase ii single arm study of carboplatin and docetaxel in treatment of first sensitive relapse of epithelial ovarian, peritoneal or tubal cancer. hypothesis: treatment with this combination in second line is safe and with a low frequency of neurologic side effect.

evaluation of toxicity and response of treatment with carboplatin and docetaxel to patients with epithelial cancer of ovary, fallopian tube or peritoneum with their first relapse occurring at least 6 months after end of first line treatment- evaluation of toxicity according to clinical toxicity criteria version 2.

Eligibility criteria:
inclusion criteria: * epithelial carcinoma of ovarian, peritoneal or fallopian tube origin. * female * age above 18 years * who performance status 0-2 * life expectancy \> 3 months * previous treatment with one platinum and taxane containing regimen. * platinum and taxane sensitive relapse * at least one evaluable/measurable lesion. * adequate hematologic, renal and liver function * consent form signed and dated before inclusion exclusion criteria: * prior treatment with more than one line of chemotherapy * concurrent severe and/or uncontrolled co-morbid medical condition. * history of previous or concurrent malignancy within the previous 5 years • history of prior serious allergic reactions such as anaphylactic shock * pregnant or lactating women (or potentially fertile women not using adequate contraception) * peripheral neuropathy \> grade 2 * history of allergy to drugs containing the excipient tween 80®. * concomitant administration of any other experimental drug under investigation or concurrent treatment with any other anti-cancer therapy * clinical evidence of brain metastases

Keywords: phase ii study, recurrent platinum-sensitive ovarian cancer docetaxel carboplatin toxicity
effects of systemic drugs on intraocular pressure

Conditions: Glaucoma, Angle-Closure; Glaucoma Suspect; Glaucoma Secondary to Drugs, Bilateral; Hypertension

Summary: to assess intraocular pressure changes among glaucoma patients on systemic antihypertensive and antihistaminic drugs.

changes in intraocular pressure in glaucomatous patients with narrow angle may elicit attacks of angle closure glaucoma. in this study we aim to assess changes in intraocular pressure (iop) among glaucomatous patients on systemic antihypertensive and antihistaminic drugs.

Eligibility criteria:
inclusion criteria: * patients with narrow angle glaucoma on systemic antihypertensive and/or antihistaminic drugs. exclusion criteria: * open angle glaucoma patients confirmed by gonioscopy examination. * cases with dense corneal opacity or iris trauma that may affects gonioscopy examination. * cases with secondary glaucoma.

Keywords: angle closure glaucoma hypertension antihistaminic antihypertensive
prophylactic cerclage for twin pregnancy with shortened cervix

Conditions: Preterm Birth; Twin Pregnancy With Antenatal Problem; Cervical Shortening

Summary: this randomized controlled trial is aimed to evaluate pregnancy and neonatal outcomes in twin pregnancies, in which a cervical cerclage is placed due to the shortening of the cervix with or without visible fetal membranes.

introduction multiple pregnancies are high-risk pregnancies and usually associated with an increased risk of neonatal morbidity and mortality, mainly due to preterm births. preterm births occur in 50% of twin pregnancies and the mean gestational age for delivery is 35.3 weeks. ten percent of all twin births take place before 32 weeks of gestation.1 preterm births are responsible for more than 70% of all neonatal and infant mortality.2 prematurity can have serious consequences for the child, such as hearing difficulties, vision impairment, learning disabilities, reduced iq, and cerebral palsy. a cervical length of ≤25 mm in twin pregnancies is a good predictor of a spontaneous preterm birth when measured around 24 weeks of gestation.3,4 numerous interventions have been attempted in order to prevent preterm births in twin gestations, but until now, no intervention has been effective. use of cerclage in twin pregnancies is controversial. some experts claim that placing a cervical cerclage could increase the risk of preterm births.5 however, there is growing evidence of beneficial effect of applying cervical cerclage. based on a few, small, controlled trials, cervical cerclage may extend the pregnancy, if it is applied to a cervix of less than 15 mm.6,7 such practice is still in need for further validation by well-structured and powered randomized controlled trials. rationale: pregnant in twins with history suggesting cervical weakness and evidence of shortened cervix in the current pregnancy might get benefit from mechanical support by cervical cerclage in trial to reduce the risk of preterm birth.

Eligibility criteria:
inclusion criteria: * age between 18-45 years. * dichorionic twins. * transvaginal sonographic cervical length is \<25 mm with or without internal os dilatation ≥10 mm at 14-20 weeks gestational age. * asymptomatic. exclusion criteria: * triplets and quadruplets. * monochorionic twins. * threatened/ inevitable miscarriage * bulging membranes through the external os. * extremes of age. * major fetal anomalies. * known cases with uterine anomalies e.g. bicornuate uterus, uterus didelphis... etc. * fetal demise. * fetal reduction in the current pregnancy.
the effect of bedside whiteboard use on anxiety, depression and nursing care in chronic obstructive pulmonary patients

Conditions: COPD; Nursing Care

Summary: abstract chronic obstructive pulmonary disease (copd) is a disease characterized by the inability of the body to adequately exchange gases, resulting in progressive shortness of breath that can form secretions and compromise the performance of daily activities. copd is reported as the third most common cause of death worldwide, with 3.23 million deaths in 2019. anxiety and depression are common in individuals with copd. however, copd is more common in patients with other chronic diseases such as hypertension, diabetes, cancer or musculoskeletal disorders. communication is a key component in interprofessional care as well as in improving patient care outcomes. strategies to address gaps in the quality of information and communication between patients, caregivers and professionals improve patient safety as well as quality of care. one of these strategies is the use of whiteboards at the bedside. the use of whiteboards at the bedside has emerged as a strategy to improve interprofessional team participation, communication and information sharing with care teams, patients and families. this study will be conducted in randomized controlled single blind parallel groups to examine the effect of bedside whiteboard use on anxiety, depression and nursing care satisfaction in copd patients. the research will consist of patients who are hospitalized in atatürk university research hospital chest diseases clinic and who meet the inclusion criteria. in the results of the research, it is thought that the use of whiteboard will affect the communication between health care team members.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * having a medical diagnosis of copd * to be in a condition to be followed up with at least 7 days exclusion criteria: * - having strong reading and comprehension skills
music intervention for preterm birth

Conditions: Preterm Birth

Summary: this study will test a music intervention (mi) versus a sham control (sc) arm which only includes a verbal intervention, to determine if the effects of the music intervention will reduce the biological impact of chronic stress among pregnant black women, reduce preterm birth, and improve infant outcomes.

preterm birth occurs at unacceptably high rates in the united states, with black women disproportionately affected. a long-recognized risk factor for preterm birth in this population is the relentless exposure to intersectional stress related to racial and sexual discrimination, poverty, and neighborhood disadvantage that black women often experience from an early age. in this interdisciplinary study, the investigators bring together experts in preterm birth, music therapy, and metabolomics to address this health disparity by testing the efficacy of a live, culturally based music intervention to reduce the production of metabolites and metabolic pathways associated with chronic stress and thereby improve birth outcomes.

Eligibility criteria:
inclusion criteria * aged 18 to 40 years * generally healthy pregnant women in the first trimester of pregnancy exclusion criteria: * non-pregnant women * women with a chronic medical condition that could impact pregnancy health or duration * women regularly taking any medications other than prenatal vitamins

Keywords: chronic stress preterm birth black women stress metabolomics of chronic stress music and medicine music intervention
prediction of pulmonary rehabilitation outcomes in patients with chronic respiratory disease based on metabolomics: a prospective cohort study

Conditions: Chronic Obstructive Pulmonary Disease; Bronchiectasis

Summary: to comprehensively evaluate the pulmonary rehabilitation (pr) outcomes of patients with chronic respiratory disease (crd), and to screen biomarkers for predicting different pr outcomes of patients with crd using metabolomics methods, and to build a prediction model.


Eligibility criteria:
inclusion criteria: * for copd 1. meets the global initiative for chronic obstructive lung disease (gold) 2022 definition of stable copd; 2. age 30-75 years; 3. lung ct images only showed chronic bronchitis and emphysema; 4. agree to participate in the study and is able to cooperate with exhaled breath condensate collection. * for bronchiectasis 1. lung ct showed bronchiectasis; 2. age 18-75 years; 3. spirometry suggests obstructive ventilatory dysfunction: forced expiratory volume in one second (fev1) is less than 70% of forced vital capacity (fvc) post bronchodilator inhalation. exclusion criteria: 1. asthma or other respiratory diseases 2. history of pulmonary surgery 3. α1 antitrypsin deficiency 4. autoimmune diseases 5. patients with acute myocardial infarction, chronic heart failure, severe cerebral infarction or cerebral hemorrhage 6. a history of malignant disease now or within 2 years 7. history of acute exacerbation or change of medication in the past 4 weeks 8. a history of blood transfusion within the last 4 weeks 9. drugs or alcohol abuse 10. breastfeeding or pregnant women 11. unable to cooperate with pulmonary rehabilitation for various reasons

Keywords: pulmonary rehabilitation chronic respiratory disease metabonomics
autologous bone marrow stromal cell and endothelial progenitor cell transplantation in ischemic stroke

Conditions: Stroke; Infarction, Middle Cerebral Artery

Summary: the purpose of this study is to evaluate the feasibility, efficacy, and safety of autologous transplantation of ex vivo expanded bone marrow stromal cells (bmscs)and endothelial progenitor cells (epcs) for treatment of patients with ischemic stroke.

this study is a multi-center, single-blind, randomized, parallel controlled trail. patients with acute cerebral infarcts within the middle cerebral arterial territory and with severe neurological deficits will be enrolled and randomly allocated into 3 groups: autologous bmscs transplantation group, autologous epcs transplantation group and placebo control group. randomization codes were established by the study statistician and were revealed only to the stem cell laboratory technician responsible for separating the cells into aliquots or preparing the placebo material. all patients will undergo a bone marrow aspiration procedure at 7 days after symptom onset. bmscs and epcs will be expanded ex vivo and then intravenously infused into own body, respectively. the control group will not receive cell therapy. observe will followed for up to 1 year after the onset. neurological score, neuroimaging, mortality of any cause, side effects, and new-onset comorbidities will be monitored and compared between each groups.

Eligibility criteria:
inclusion criteria: 1. patients aged 18 to 80 years, within 7 days of the onset of symptoms 2. ischemic lesion within the mca territory as assessed using diffusion-weighted imaging (dwi) 3. the national institutes of health stroke scale (nihss) ≥ 7 at day 7 after the onset 4. signed informed consent exclusion criteria: 1. lacunar syndrome 2. diagnosis other than ischemic stroke(eg. intracranial hemorrhage or intracranial tumor) 3. hematological causes of stroke 4. severe respiratory, hepatic, or renal disorders 5. presence of severe febrile illness or viral diseases 6. malignant diseases 7. presence of autoimmune diseases 8. positive response of penicillin skin test, or multiple drug allergies 9. breast-feeding or pregnant women

Keywords: central nervous system diseases stroke infarction, middle cerebral artery cerebral infarction cerebrovascular accident stem cell transplantation mesenchymal stem cell transplantation bone marrow stromal cells mesenchymal stem cells endothelial progenitor cells adult stem cells cell therapy
non-invasive quantitative imaging of human local arterial wall elasticity using supersonic shear imaging

Conditions: Healthy Volunteers; Vascular Ehlers Danlos Syndrome

Summary: arterial stiffness is associated with increased risk of cardiovascular events and death. most of existing technique need dedicated device for arterial stiffness evaluation and indirect calculation of intra arterial pressure. supersonic shear imaging (ssi) is a novel non-invasive technique based on remote palpation of biological tissues that can image with very high temporal resolution (up to 10,000 images/s) and quantify the local viscoelastic properties of tissues. the investigators goal was to apply this ssi technique for arterial stiffness evaluation and local pulse wave velocity (pwv) calculation. as a first step, the primary goal of this study is to establish normal values of local pulse wave velocity and arterial stiffness (carotid and femoral) by ssi on hundred healthy volunteers.

provide a more extensive description, if desired. avoid duplication of information to be recorded elsewhere, such as eligibility criteria or outcome measures.

Eligibility criteria:
inclusion criteria for healthy volunteers * healthy volunteers between 18 and 70 years old of two sexes. * caucasian origin * no tobacco or stopped for more than 5 years * bmi between 18 and 30 kg/m2. * blood pressure after 5 minutes of rest \< 140 and 90 mmhg. * biological test (haematological biochemistry test in blood , urine test and toxicology tests are all normal) ecg, blood pressure and heart rhythm normal. * all volunteers received information on the research and signed the consent form. * health system protection required inclusion criteria for patient : * age between, 18 et 70 years old for the two sexes * presence of two major criteria of villefranche classification (am j med genet 1998 ;77:31-7) and/or heterozygote pathogen mutation of col3a1 gene. * at least 4cm long normal arterial segment (carotid or femoral) analyzed by mode b echograph. * all patient received information on the research and signed the consent form. * health system protection required general exclusion criteria : * pregnancy * echograph gel allergy * local artery disease (dissection or thrombosis) * arrhythmia * no health insurance coverage * incapacity or refused to sign the consent form exclusion criteria for healthy volunteers * acute or chronic systemic disease (atherosclerosis) * alcohol abuse or drug abuse (cocaine,cannabis,etc..) * active or past tobacco * hypercholesterolemia (ldlc \>1.09 g/l) * exclusion period according to the national record for volunteer of clinical trial. exclusion criteria for patients * no intact (carotid or femoral) segment for ssi analysis * at2 inhibitors or beta blockers treatment will be notified but are not considered as exclusion criteria.

Keywords: arterial stiffness pulse wave velocity ultrafastecho supersonic shear imaging