Kornimate/medical-research-clean huggingface dataset:
screens, virtual reality and digital addiction (evadd)

Conditions: Internet Addiction Disorder

Summary: this is an observational study questionnaire-based. this study will be carried out to evaluate the methods of consumption (work/outside work), the characteristics of the tools used, the addictive risk, the consequences on mental and physical health and the impact on quality of life of people exposed to screens and smartphones. a sample of 800 000 people will be used to learn about the entire french population. participants will be asked to respond to an anonymous digital survey. the ultimate goal of this work is to have quality information to help facilitate therapeutic efforts in support of those who may need it.

inappropriate use of the smartphone is defined as excessive use of the technological tool interfering with social and/or professional activities causing negative consequences such as the alteration of certain cognitive functions such as attention. in addition, the excessive use of smartphones has generated a new form of digital symptoms such as nomo or nomophobia (addiction to mobile phones by compulsive checking of new messages or social networks) and fomo (fear of being excluded enriching social experiences, fear of missing out). from the perspective of social media addiction, research has shown that there is a fine line between habitual, frequent, unproblematic use and problematic and possibly addictive use of social media. users who express symptoms and consequences traditionally associated with substance addiction (salience, mood changes, tolerance phenomenon, craving, withdrawal, relapse) could be addicted to social media. nowadays, abstinence from digital media and consumption cannot realistically be achieved in the context of sr addiction, as the internet and social media have become essential parts of our lives. rather than shutting down social media altogether, therapy should focus on establishing controlled social media use and digital media awareness. this study will be carried out to evaluate the methods of consumption (work/outside work), the characteristics of the tools used, the addictive risk, the consequences on mental and physical health and the impact on quality of life of people exposed to screens and smartphones. a sample of 800 000 people will be used to learn about the entire french population. participants will be asked to respond to an anonymous digital survey. this is an observational study questionnaire-based. the ultimate goal of this work is not to overpathologize daily behaviours, but to have quality information to help facilitate therapeutic efforts in support of those who may need it.

Eligibility criteria:
inclusion criteria: * 18 years old or older (adult) * members of the pro-btp insurance (email list) * understanding french language exclusion criteria: * less than 18 years old

Keywords: smartphone social media
analysis of the factors influencing the occurrence of peri-implant inflammation in patients with oral implant repair and study on the maintenance effect of subgingival sandblasting

Conditions: Peri-implantitis; Dental Implant Complications; Periodontal Inflammation; Gingival Diseases

Summary: abstract objective the purpose of this study was to analyze the factors affecting the occurrence of peri-implant inflammation in patients with oral implant repair, and to explore the effect of subgingival sandblasting technology on the maintenance of microecology around the implant, so as to provide a basis for optimizing clinical prevention and treatment strategies. method ninety-six patients with early periimplantitis treated in our hospital from july 2022 to july 2024 were selected as the inflammation group. all patients were randomly divided into control group, glycine subgingival sandblasting group and erythritol subgingival sandblasting group (n=32). the clinical therapeutic effect of the two groups was compared. a total of 102 patients who underwent oral implant repair in our hospital during the same period without peri-implant inflammation were selected as the group without inflammation. the independent risk factors of peri-implant inflammation were analyzed.


Eligibility criteria:
inclusion criteria clinical diagnosis of peri-implantitis (pd ≥4 mm with bop/suppuration) at least one functional dental implant in place for ≥6 months willing and able to maintain standard oral hygiene protocol no antibiotic or anti-inflammatory drug use in the past 30 days absence of uncontrolled systemic diseases (e.g., diabetes, hypertension) complete baseline clinical data available (medical history, radiographs, lab results) exclusion criteria acute oral infections requiring immediate treatment history of radiation therapy to the head/neck region severe uncontrolled periodontal disease active malignancy or current cancer treatment coagulation disorders or anticoagulant therapy pregnancy or lactation cognitive impairment affecting compliance allergy to glycine or erythritol compounds non-inflammatory group additional criteria successful implant placement with no signs of inflammation (pd ≤3 mm, no bop) matched to study group by age (±5 years) and implant location meets all other inclusion/exclusion criteria regarding systemic health note: all participants must provide informed consent. healthy volunteers without implants are not eligible.
steroid hormones, th1/th2 cytokines and reproductive status

Conditions: Arthritis, Rheumatoid; Healthy; Pregnancy

Summary: this study is designed to evaluate blood th1 and th2 immunoregulatory cytokine production and hormonal levels associated with the third trimester of pregnancy and the postpartum state. cytokine and hormone levels will be assessed in blood specimens obtained from healthy pregnant and postpartum females and compared to levels from premenopausal non-pregnant and non-postpartum females. blood samples obtained at 30-36 weeks of gestation and 2-6 weeks postpartum will be the primary study points. samples will also be obtained from pregnant, postpartum, and non-pregnant, non-postpartum, premenopausal female patients with rheumatoid arthritis. additional data will be generated from samples from normal males, which will be compared with data from females. we expect to find that pregnancy is associated with enhanced th2 cytokine expression and that the postpartum state is associated with enhanced th1 cytokine expression. we expect to see differences in cytokine expression between males and females as well. we seek to gather data supporting the view that distinct hormonal environments regulate these contrasting immunological states.

this study is designed to evaluate blood th1 and th2 immunoregulatory cytokine production and hormonal levels associated with the third trimester of pregnancy and the postpartum state. cytokine and hormone levels will be assessed in blood specimens obtained from healthy pregnant and postpartum females and compared to levels from premenopausal non-pregnant and non-postpartum females. blood samples obtained at 30-36 weeks of gestation and 2-6 weeks postpartum will be the primary study points. samples will also be obtained from pregnant, postpartum, and non-pregnant, non-postpartum, premenopausal female patients with rheumatoid arthritis. additional data will be generated from samples from normal males, which will be compared with data from females. we expect to find that pregnancy is associated with enhanced th2 cytokine expression and that the postpartum state is associated with enhanced th1 cytokine expression. we expect to see differences in cytokine expression between males and females as well. we seek to gather data supporting the view that distinct hormonal environments regulate these contrasting immunological states.

Eligibility criteria:
no current medications or hormone therapy within the last 3 months.

Keywords: androgens female immunology neuroendocrine axis rheumatoid arthritis postpartum pregnancy
comparison of different weight loss methods in obese individuals

Conditions: Obesity

Summary: although obesity is a rapidly increasing epidemic worldwide, it is associated with many health-related comorbidities. as a result of the developments in social life and observes the sedentary life in individuals, an effect of the age of technology the fact that this epidemic will cause even massive health problems in the coming period affecting the health systems of countries and indirectly their economies that, this situation necessitates the creation of alternative treatment methods for the prevention of obesity. this study aims to determine the effect of a therapy approach that can be applied to the vagus nervous system, which is associated with many organs and systems, on weight loss and general health. as an alternative treatment against lifestyle changes such as diet and exercise, individuals have made for weight loss.


Eligibility criteria:
inclusion criteria: * age range 18 - 65 * being in the stage i, ii and iii obesity class exclusion criteria: * those with unstable dm * those with stage ii hypertension * those who have had cardiovascular disease (especially those who have had an attack) * those with pulmonary disease * those with kidney disease * orthopedic restrictions * those with mnd * those tied to the chair
contribution of hepatic and intestinal lipoproteins to human atherosclerosis

Conditions: Heart Disease

Summary: this study will use excess tissue from endoscopic or surgical procedures to examine the elements of plaque that are found in the carotid walls of patients who have a type of heart and blood vessel disease called atherosclerosis. tissue will be collected from patients undergoing carotid procedures as well as patients undergoing liver and/or intestinal biopsies. this lab study will examine the different types of proteins that play a role in developing heart plaque.


Eligibility criteria:
inclusion criteria: * age ≥18 years * scheduled for a clinically indicated, standard-of-care carotid endarterectomy (cea) or scheduled for a clinically indicated, standard-of- care surgical, laparoscopic or endoscopic intestinal biopsy or excision or scheduled for a clinically indicated, standard-of-care surgical, laparoscopic or endoscopic liver biopsy or partial resection/excision * ability and willingness to consent and authorization for use of phi exclusion criteria: * age ≤18 years * inability or unwillingness to consent and authorization for use of phi * for carotid patients - history of carotid trauma, that is determined by the principal investigator to significantly have changed the carotid tissue structure * for carotid patients - history of middle- or large-vessel vasculitis, that is determined by the principal investigator to significantly have changed the carotid tissue structure
therapeutic controlled hypothermia in the treatment of neonates with severe necrotizing enterocolitis

Conditions: Necrotizing Enterocolitis

Summary: hypothesis: controlled hypothermia to 33.5c for 48 hours reduces the severity of critical illness in neonates with severe necrotizing enterocolitis.


Eligibility criteria:
inclusion criteria: * weight at diagnosis \> 700 grams * confirmed nec (bell's stage ii or iii) * radiological evidence of pneumatosis coli * systemic compromise as defined by increase in ventilation requirement and/or requiring inotopic support

Keywords: hypothermia cooling necrotizing enterocolitis nec neonates preterm
efficacy of two concentrations of autologous serum for the treatment of severe dry eye

Conditions: Dry Eye; Keratoconjunctivitis Sicca; Sjogren's Syndrome; Corneal Diseases; Conjunctival Diseases; Keratitis; Lacrimal Apparatus Diseases

Summary: the purpose of this study is to compare the effects of autologous serum 20% and autologous serum 50% for the treatment of severe dry eye syndrome

to determine the difference between autologous serum 20% vs 50%, in terms of improvement of symptoms, improvement of ocular surface parameters and acceptable tolerability in patients with severe dry eye syndrome.

Eligibility criteria:
inclusion criteria: * man/woman ≥ 18 years old, able to freely give consent to participate in the study * at least 1 of the following tests altered: * ocular surface disease index (osdi) test symptoms \> 32 * but ≤5 seconds * oxford staining ≥ 3 * schirmer test without anesthesia ≤ 5 mm exclusion criteria: * sensitivity or known intolerance to any of the products used in the study * contraindication of venipuncture * story of ocular infections within the 6 previous months to study inclusion * any active ocular pathology other than dry eye syndrome * use of contact lenses in the 3 previous months to study inclusion * no pregnant or breastfeeding women is allowed to participate in the study. childbearing potential women must use contraceptive means during the whole study. * participation in another clinical trial in the last 30 days before study inclusion

Keywords: autologous serum concentration autologous serum 20% autologous serum 50% severe dry eye
the norwegian cervical arthroplasty trial

Conditions: Radiculopathy, Cervical

Summary: the study will compare cervical arthroplasty with cervical discectomy and fusion, in the treatment of cervical radiculopathy. the 0-hypothesis is that there is no difference between the two methods, when comparing primary and secondary outcome variables.

anterior discectomy and fusion (acdf) is in norway currently the most common operative method against cervical radiculopathy, caused by disc herniation and/or spondylosis. in the last decade cervical arthroplasty has emerged as a new alternative operative method. arthroplasty is claimed to preserve the natural motion of the spine, thereby preventing adjacent level disc disease and providing better clinical results. however, this hypothesis has not yet been adequately proven. in our study, we will prove if there is any real difference in terms of clinical effect between cervical arthroplasty and acdf.we will also compare the overall costs of the two methods, including cost-utility analyses. moreover, we will study the development of adjacent level disease by use of mri scans, and analyze cervical spine motion and disc height by use of distortion compensated roentgen analysis (dcra).

Eligibility criteria:
inclusion criteria: * age 25 - 60 years * clinical c6 or c7 root radiculopathy with corresponding radiologic findings with or without neurological symptoms * mechanical provoked pain which aggravate with physical activity or positive spurling test * radiological nerve root compression on the basis of disc herniation or spondylosis * ndi =/\> 30 percent * the patient has not responded to non-operative treatment and shown no sign of improvement during the last 6 weeks exclusion criteria: * significant spondylosis involving more than one level * intramedullary changes on mri * ankylosis at adjacent level * clinical suspicion of myelopathy * chronic generalised pain syndrome * infection * active cancer * rheumatoid arthritis involving the cervical spine * previous trauma involving the cervical spine * pregnancy * allergy against contents in cage/artificial disc * previous neck surgery * psychological or somatic illness that causes the patient not to be suitable for the study * the patient does not understand norwegian orally or in writing. * abuse of medication/narcotics

Keywords: radiculopathy, cervical nerve root compression disc, intervertebral intervertebral disk displacement spondylosis spinal osteophytosis arthroplasty, replacement diskectomy spinal fusion
efficacy and safety of losartan in children with ig a nephropathy

Conditions: Glomerulonephritis, IGA

Summary: the investigators hypothesize that using losartan would help decrease proteinuria in controlling proteinuria in children with immunoglobulin a nephropathy.

twenty nine patient with iga nephropathy with proteinuria (urine protein to creatinine ratio \> 0.3 mg/mg) were included in the study. all patients had received losartan treatment for 24 weeks. changes in blood pressure, proteinuria, renal function, and biochemical parameters were prospectively evaluated before and at 4 weeks and 24 weeks.

Eligibility criteria:
inclusion criteria: * age: 2years or older and younger than 18 years * biopsy-proven ig a nephropathy * estimated gfr ≥ 90ml/min/m\^2 * mean urinary protein-creatinine ratio \> 0.3 g/g from three first-morning spot urine collections exclusion criteria: * hypertension * under dialysis or organ transplanted * bilateral renal artery stenosis * primary hyperaldosteronism * pregnant

Keywords: losartan ig a nephropathy children proteinuria
therapeutic treatment of amyotrophic lateral sclerosis

Conditions: Amyotrophic Lateral Sclerosis

Summary: the goal of this study is to investigate the safety and tolerability of allogeneic wharton's jelly-derived mesenchymal stem cells administration in the individuals with diagnosed amyotrophic lateral sclerosis.

amyotrophic lateral sclerosis (als) is one of the progressive neurodegenerative disorders, affecting upper and lower motor neurons in the cerebral cortex, brainstem and spinal cord. hence, the signs of damage motor neurons are both at the peripheral (eg. atrophy), and central (eg. spasticity) level. there is no effective treatment for als and the majority of patients die within 5 years after diagnosis, usually due to the respiratory failure. numerous studies on murine models revealed that mesenchymal stem cells (mscs) successfully improve the clinical and pathological features of als patients. the goal of this nonrandomized, open label study is to investigate the safety and tolerability of allogeneic wharton's jelly-derived mesenchymal stem cell transplantation into the individuals with diagnosed amyotrophic lateral sclerosis. this clinical trial is conducted to test the therapeutic (neuroprotective and paracrine) effect of allogeneic wharton's jelly-derived mesenchymal stem cells (wj-mscs). all patients enrolled will have a documented history of als disease prior to enrollment. patients are recruited for a clinical trial no more than 1 year from the disease diagnosis. then, patients are divided into two groups: group i - patients receiving intrathecally one application of wj-mscs and group ii - patients receiving intrathecally three applications (each administration every two months) of wj-mscs. subsequently, allogeneic wharton's jelly-derived mesenchymal stem cell transplantation to the cerebrospinal fluid at the site of the spinal cord will be performed. finally, treatment safety, adverse events and exploratory parameters, including electromyographic (emg) studies, forced vital capacity (fvc) and functional rating scale (frs) to establish als progression rate will be recorded throughout the duration and in the post-treatment follow up period.

Eligibility criteria:
inclusion criteria: * diagnosis of the als disease before the cell transplantation (diagnose established following the el escorial criteria for definite als) * good understanding of the protocol and willingness to consent * signed informed consent * disease duration: up to 2 years * fvc \> 50% / pulmonologist certificate about respiratory function of the patient exclusion criteria: * cancer, * autoimmune diseases * renal failure, * subject is a respiratory dependent. * subject unwilling or unable to comply with the requirements of the protocol * pregnancy, breastfeeding
effects of hypolipemic treatment on adipokines

Conditions: Hyperlipidemia; Impaired Fasting Glycemia

Summary: the study is planned to show whether monotherapies or combined hypolipemic therapy influence the fasting plasma glucose, serum adipokines (leptin, adiponectin, resistin) and proinflammatory cytokines (interleukin-6, tnf alpha) during 30 and 90 day course.


Eligibility criteria:
inclusion criteria: * age (35-64yr) * primary hyperlipidemia (total cholesterol \>200mg/dl, triglycerides \>150mg/dl) * impaired fasting glycemia (glycemia 100-125mg/dl) * for women: * menopause (\>12 months) * post hysterectomy * mechanical contraception * obtained informed consent exclusion criteria: * secondary hyperlipidemia * morbid obesity (bmi\>40kg/m2) * alcohol or drug abuse * acute or chronic inflammation * congestive heart failure (nyha iii or iv) * unstable ischaemic heart disease * moderate or severe hypertension * cancer in less than 5 years * chronic kidney disease (stage iii-v) * liver failure * diabetes * oral contraception * not compliant patient * laboratory results: * alanine transferase (\>3xuln) * creatine kinase (\>5xuln) * haemoglobin (\<10/dl) * plt (\<100g/l) * wbc (\ 10g/l)

Keywords: hyperlipidemia impaired fasting glycemia adipokines atorvastatin fenofibrate
culturally adapted i-cbt for farsi/dari speaking migrants

Conditions: Depressive Symptoms; Anxiety Symptoms; Grief; Psychological Trauma; Insomnia; Resilience; Stress; Psychological Well Being; Marital Relationship; Wellbeing; Common Mental Health Problems; Rumination

Summary: the aim of this randomized controlled trial (rct) is to investigate the effectiveness of a culturally adapted internet-based cognitive behavioral therapy (i-cbt) intervention in reducing symptoms of common mental health issues among farsi/dari-speaking youth migrants and refugees. investigator hypothesizes that there will be a significant decrease in psychological symptoms after participants receive the intervention compared to a control group.

participants who are included in the study will be allocated to the experimental group and the control group (waiting list). participants will be invited to participate tailored i-cbt intervention over 10-weeks. intervention covers common psychological issues. participants will have access to support through a chatting function, during the interventional period. intervention effects will be measured prior-treatment, post-treatment, and 6 months post-treatment.

Eligibility criteria:
inclusion criteria: * between the ages of 15 and 29. * a score above the cut-off 1.75 on hscl-25 * has a refugee or migrant background * has a good and stable internet connection * has access to a computer, tablet or smartphone * is fluent in reading and writing arabic * has the ability to dedicate time to take part in the intervention for 6-10 weeks. exclusion criteria: * is suffering from a severe mental illness, such as psychosis or severe depression. * is suffering from substance abuse * is undergoing a psychological treatment * has a high risk of suicide

Keywords: refugee cognitive behavioral therapy psychological problems persian speaking psychological well-being youth mental problems resilience asylum seeker
crystalloid versus colloid rapid co-load for cesarean delivery under spinal anesthesia

Conditions: Pregnancy; Cesarean Delivery; Hypotension

Summary: the study aims to compare crystalloid co-loading and colloid co-loading in parturients receiving prophylactic phenylephrine infusion during cesarean delivery in terms of the incidence of hypotension.


Eligibility criteria:
inclusion criteria: * healthy, full-term parturients who scheduled to undergo elective cesarean delivery under spinal anesthesia. exclusion criteria: * multiple pregnancy * gestational age \< 36 weeks * preexisting or pregnancy-induced hypertension * morbid cardiovascular impairments * cerebrovascular disease ⑥ known fetal anomaly ⑦ contraindications to spinal anesthesia ⑧ any sign of onset of labor ⑨ body weight \ 90 kg ⑩ height \ 180cm