Kornimate/medical-research-clean huggingface dataset:
thermography and burning mouth syndrome

Conditions: Burning Mouth Syndrome

Summary: medical thermography is a noninvasive technique that allows an examiner to visualize and estimate the temperature of the body . this technique allows for an evaluation of the functionality of the structures, which is why it is considered a physiological test and records the variation in the surface temperature of the human body based on the infrared radiation emitted by the surface of that body .subjects with burning mouth syndrome (bms) have altered sensitivity and pain thresholds for thermal stimuli compared to a control group an objective of this study is to standardize temperature values derived from thermograms of the tongue in bms .

an objective of this study is to standardize temperature values derived from thermograms of the tongue in bms subjects will make one visit to our clinic with burning mouth syndrome and control healthy . they will be asked to acclimate to room temperature for at least 20 minutes. subjects are requested not to consume hot drinks or food for at least an hour before imaging and not to use any skin preparations. during the tests, infrared thermal images were taken immediately after subjects protruded their tongues forward and downward to the desired position

Eligibility criteria:
inclusion criteria: * written informed consent signed he patients were diagnosed with bms according to the criteria of the international classification of headache disorders exclusion criteria: * fibromyalgia * fever * reflux * cancer, * oral infection, * pregnant or breastfeeding women
cleft palate technique and maxillary growth

Conditions: Cleft Palate; Growth

Summary: comparison of the maxillary growth between cleft palate patients that underwent to repair by 2 flap palatoplasty versus furlow with buccinator technique


Eligibility criteria:
inclusion criteria: * 5-6 years old childreen with previous treated complete cleft lip and palate, nonsyndromic. * lip and palate repair performed by one craniofacial surgeon exclusion criteria: * patients with syndromic cleft lip. * redu cases * bilateral cleft lip * patient older 6years or younger 5 years. * associated cardiac anomalies. * any systemic condition
association between bmi and covid-19

Conditions: SARS-CoV 2

Summary: this study will involve collection of pseudonymized data from hospital-based data reporting at multiple international sites. collating data from a large volume of patients with covid-19 admitted in icu across multiple international sites will enable investigation of whether obesity is a risk factor for complicated from of sars-cov-2 in adult patients and whether this association is independent of other cardiometabolic risk factors.

the covid-19 pandemic is characterized by a high frequency of patients with severe acute respiratory syndrome coronavirus-2 (sars-cov-2), who often require invasive mechanical ventilation (imv). body mass index (bmi) was however rarely mentioned in early clinical reports. disease severity gradually increased with body mass index (bmi) categories among patients admitted in intensive care unit (icu) for severe acute respiratory syndrome coronavirus-2 (sars-cov-2), the need for invasive mechanical ventilation (imv), reaching 85% in patients with class ii or iii obesity ( bmi \> 35 kg/m2). in summary, there is an urgent need for more evidence on the specific role played by obesity in the development of covid-19 complications, and more particularly of severe acute respiratory syndrome coronavirus-2 (sars-cov-2)

Eligibility criteria:
inclusion criteria: * participant is aged 18 years or over * has been admitted to icu with covid-19 disease. * covid-19 disease has been confirmed by pcr for sars-cov-2 * height and weight or bmi on admission has been recorded * data has been collected in an ethical manner as part of a national database or clinical auditing process approved by the local institution or collaboration exclusion criteria: -there are no exclusion criteria

Keywords: intensive care invasive mechanical ventilation body mass index obesity
impact of stress management training on the resilience and stress of student nurse anaesthetists

Conditions: Stress, Psychological

Summary: the study aims to evaluate the effectiveness of stress management training provided to student nurse anaesthetists on: their level of chronic perceived stress in the last month, their level of acute perceived stress each day for one month, their level of resilience and their level of sleep quality.

this trial will be conducted at the chu grenoble alpes (chuga). volunteer nurse student anaesthetists trained in stress management will complete questionnaires assessing resilience, perceived stress over the past month, sleep quality and will assess perceived stress on each working day using the visual analogue stress scale over 3 periods of the working day. the results of the trained students will be compared to the results of the untrained students who participated in the anaesthesia worker stress in the operating room survey registered under the clinical trial number: nct05392972 the main objective is to evaluate the impact of stress management training provided to nurse anaesthetist students on their chronic perceived stress over one month assessed with the perceived stress scale 10. the secondary objectives are: 1. to compare the level of resilience of students who have received training in stress management methods with that of students who have not received such training. (comparison of the average of the connor-davidson resilience scale for each population) 2. compare the perceived stress during a working day in students who have received stress management training to those who have not. (comparison of the average of the two visual analogue stress scales (vas stress) (start of shift/end of shift) collected on working days over a period of one month for both populations) 3. compare the stress peaks experienced (acute stress) by students who have received stress management training and those experienced by students who have not. (comparison of the median of the stress vas peaks of the two populations followed over one month). 4. determine whether the quality of sleep of the students is influenced by the stress management training (comparison of the pittsburgh sleep quality index (psqi) of the nurse student anaesthesist population that received stress management training with the psqi of population that did not receive this training). 5. conduct a satisfaction survey among the nurse student anaesthesist regarding the training provided by the grenoble training institute and identify the stress management methods retained as useful by the nurse student anesthesist following this training.

Eligibility criteria:
inclusion criteria: * student nurse anaesthetist exclusion criteria: * student objecting to the use of their personal information * student on study leave. * student on sick leave during the study period.

Keywords: resilience acute stress sleep quality anaesthetist chronic stress
long-term safety and efficacy of tenofovir amibufenamide in patients with chb

Conditions: Hepatitis B, Chronic

Summary: tenofovir amibufenamide (tmf) is a novel prodrug of tenofovir that has been widely used in mainland china for the treatment of chronic hepatitis b (chb). the previous registrational study (nct03903796) has established the non-inferior virologic efficacy of tmf to tenofovir disoproxil fumarate (tdf), while demonstrating higher rates of alanine aminotransferase (alt) normalization and improved bone and renal safety profiles. this study presented the long-term efficacy and safety of tmf in a phase iv study.

participants from the phase iii registrational trial of tmf were enrolled and followed for another seven years, starting at week 144 in the phase iii study as the baseline. once-daily oral dose of 25 mg tmf were maintained in all participants. clinical assessments were conducted every 24 weeks. the primary efficacy endpoint was the percentage of patients with serum hbv dna levels below the quantification limit at week (144+) 96.

Eligibility criteria:
inclusion criteria: * patients with hbeag-positive or hbeag-negative chronic hepatitis b who completed a pivotal phase iii clinical study of hs-10234-301 exclusion criteria: * 1) completion of hs-10234-301 pivotal phase iii clinical study interruption of tmf treatment for more than 24 weeks or continuous use of alternative, commercially available hepatitis b antivirals for more than 24 weeks (participants who have discontinued tmf for more than 24 weeks can only be enrolled in this study after investigator evaluation and confirmation) 2）evidence of hepatocellular carcinoma (e.g. as evidenced by recent imaging). 3)significant bone disease (e.g. osteomalacia, chronic osteomyelitis, osteogenesis imperfecta, osteochrondroses), or multiple bone fractures. 4）currently receiving therapy with immunomodulators (e.g. corticosteroids), investigational agents, nephrotoxic agents, or agents capable of modifying renal excretion. 5）known hypersensitivity to study drugs, metabolites, or formulation excipients. 6) in the investigator's judgment, current alcohol or substance abuse may interfere with the subject's compliance with the study requirements 7）current alcohol or substance abuse judged by the investigator to potentially interfere with participant compliance.

Keywords: hepatitis b, chronic；hbv infection
grass observational study

Conditions: Grass Allergy; Rhinoconjunctivitis

Summary: grass pollen allergens are universally recognised as a major cause of allergic diseases in humans, including asthma, allergic rhinitis, conjunctivitis and dermatitis. the purpose of the current study is to evaluate allergy symptoms and allergy medication in subjects with grass-related rhinoconjunctivitis.


Eligibility criteria:
inclusion criteria: * history of moderate to severe rhinoconjunctivitis consistent with allergy to grass for at least 2 years. * forced expiratory volume in 1 second (fev1) of at least 70% of predicted value or personal best if available at the screening visit. * perennial rye grass or timothy grass-specific ige ≥ 0.35 ku/l as measured by immunocap®. * positive skin prick test to perennial rye grass or timothy grass allergen exclusion criteria: * positive skin prick test ≥ 5 mm to any confounding, co-existing seasonal allergens likely to be present during the pre-season baseline and grass pollen period. * medical records of symptomatic perennial allergic rhinitis and/or asthma or a positive skin test ≥ 5 mm due to a perennial allergen to which the subject is regularly exposed (moulds, dust mites, cockroaches, and animal dander) and which cannot be avoided during the course of the study. * previous immunotherapy treatment with any grass allergen for more than 1 month within 5 years prior to screening. * subjects who had been treated with any non-grass licensed allergen immunotherapy extracts or non-grass investigational immunotherapy for more than 1 month within 1 year.
infusion laboratory: protocol 2 (lisuride) - 3

Conditions: Cocaine-Related Disorders

Summary: the purpose of this study is to evaluate clinical safety issues pertaining to lisuride, to cocaine, and to its interaction in a chronic, crack dependent population, and to determine how pretreatment with lisuride modifies the subjective as well as physiological effects of cocaine.


Eligibility criteria:
inclusion criteria: m/f ages 21-50. meet dsm-iv criteria for cocaine dependence. agree to conditions of the study and sign informed consent. exclusion criteria: psychiatric disorder that requires medication therapy. history of seizures. pregnant and/or nuring women. dependence on etoh or benzodiazepines or other sedative/hypnotics. acute hepatitis. other medical condtions that deem participation to be unsafe.

Keywords: cocaine dependence
assessment of head and neck tumor hypoxia using 18f-fluoromisonidazole

Conditions: Squamous Cell Carcinoma; Head and Neck Neoplasms; Metastases, Neoplasm

Summary: the purpose of this clinical research study is to answer the following questions using 18f-fluoromisonidazole as an imaging agent: 1. do cells exist in human tumors that are at very low oxygen levels (hypoxic cells)? 2. if hypoxic cells exist in human tumors, do they effect the ability of radiotherapy to control human tumors? 3. can positron emission tomography (pet scanning) detect hypoxic cells in human tumors?

hypoxic (low oxygen) cells have long been known to exist in animal tumors. it is also known that hypoxic cells are more difficult to eliminate with radiotherapy than tumor cells at normal levels of oxygen (normoxic cells). however, the extent to which hypoxic cells limit the curability of human tumors is uncertain. to determine if hypoxic cells exist in human tumors and how hypoxic cells might influence the efficacy of radiotherapy, this study involves direct measurements of oxygen levels in human tumors compared to the tumor uptake of the experimental drug, 18f-fluoromisonidazole (18f-fmiso), visualized with pet scanning. 18f-fluoromisonidazole has been used with pet imaging to tell the difference between growing tumors which have high and low oxygen content. before beginning radiotherapy, a pet scan (series of pictures, 20 min. scan) will be performed at 2 hours after an intravenous injection of a small amount of radioactive traces drug, 18f-fluoromisonidazole (18f-fmiso) to observe the active hypoxia tumors areas. upon completion of the 18f-fmiso pet scan, direct oxygen measurements will be obtained by placing a small needle into the tumor under computer tomographic (ct) guidance. the pet scan and needle measurements will be repeated every 4 weeks into the course of radiotherapy and again after the completion of radiotherapy. the measurement obtained by 18f-fmiso pet scanning (non-invasive technique) and by direct needle measurements (invasive technique) will be correlated with the eventual treatment outcome for future use.

Eligibility criteria:
inclusion criteria: * histologically proven squamous cell carcinoma of head and neck wth metastatic neck nodes greater than or equal to 2cm * karnofsky performance status greater or equal to 60% exclusion criteria: * no prior irradiation or surgery to head/neck area * no prior chemotherapy within 1 month of participation and have recovered from associated related effects * not pregnant * any intercurrent medical or physiologic disorder which would prevent informed consent * underlying medical problems which would compromise technical ability to deliver a "standard course" of radiation therapy * patients with pt or ptt over 1.5 times normal

Keywords: squamous cell carcinoma of head and neck
evaluation of efficacy and safety of vx-548 for painful diabetic peripheral neuropathy (dpn)

Conditions: Diabetic Peripheral Neuropathy

Summary: the purpose of this study is to evaluate the efficacy and safety of vx-548 doses in treating painful dpn.


Eligibility criteria:
key inclusion criteria: * diagnosis of diabetes mellitus type 1 or type 2 with * glycosylated hemoglobin a1c (hba1c) ≤9%; and * presence of bilateral pain in lower extremities due to dpn for at least 1 year key exclusion criteria: * painful neuropathy other than dpn * history of cardiac dysrhythmias requiring anti-arrhythmia treatment(s) * history of a clinical atherosclerotic event, such as myocardial infarction or stroke, within the past 12 months other protocol defined inclusion/exclusion criteria may apply.
effect of upper thoracic manipulation on neck pain and selected muscle activities

Conditions: Chronic Neck Pain

Summary: this study will investigate the immediate and short-term effects of upper thoracic manipulation versus sham upper thoracic manipulation on pain intensity, cervical rom, the myoelectric activity of the sternocleidomastoid muscle and upper trapezius muscle during maximum voluntary isometric contraction.

this study will investigate the immediate and short-term effects of upper thoracic manipulation versus sham upper thoracic manipulation on pain intensity measured by the visual analogue scale, cervical rom measured by crom, the myoelectric activity of the sternocleidomastoid muscle and upper trapezius muscle during maximum voluntary isometric contraction measured by neuro-soft using surface electrodes. all outcomes will be measured pre-intervention, immediately post-intervention, one-week post-intervention, two-week post-intervention.

Eligibility criteria:
inclusion criteria: 1. male and female subjects diagnosed and classified as having chronic non-specific np with mobility disorders based on clinical guidelines of np: * having np for at least 3 months that may be associated with referred shoulder or upper extremity pain (blanpied et al., 2017; erdem et al., 2021; puntumetakul et al., 2015). * present with a limitation of cervical rom and their pain can be provoked by sustained end-range spinal movements or positions will be included (blanpied et al., 2017). * patients present with unilateral or bilateral symptoms will be included (blanpied et al., 2017; yang et al., 2015). 2. age between 18-40 (j. dunning \& rushton, 2009) 3. negative four tests of the wainner cluster to exclude np with radiating pain (wainner et al., 2003). 4. hypomobility of at least one of the upper thoracic vertebrae (t1-t4) during segmental mobility assessment (ssavedra-hernández et al., 2011). exclusion criteria: 1. subjects diagnosed as cervical radiculopathy or myelopathy (ssavedra-hernández et al., 2011). 2. a history of whiplash injury, past cervical or thoracic surgery, rheumatoid arthritis, spinal fracture, heart disease, a recent significant trauma, and meningitis (joshi et al., 2020; puntumetakul et al., 2015). 3. the presence of contraindications of spinal manipulation as spinal infection and spinal osteoporosis(ssavedra-hernández et al., 2011).

Keywords: neck pain thoracic manipulation manual therapy neck pain with mobility deficits muscle activity
spc2996 in chronic lymphocytic leukaemia

Conditions: Chronic Lymphocytic Leukemia

Summary: the purpose of this study is to determine whether spc2996 is effective and safe in the treatment of chronic lymphocytic leukaemia (cll)

chronic lymphocytic leukaemia (cll) is the most common leukaemia in adults in the us and most of western europe. many patients suffering from cll have tumour cells expressing high amounts of bcl-2 protein. since over expression of bcl-2 inhibits apoptosis, it is possible that this gene participates in the pathogenesis of cll. by lowering the bcl-2 protein in these tumour cells the cells may go into apoptosis due to changed balance in pro- and anti apoptotic proteins and thereby it might be possible to induce a tumour response. the study is an open-labelled, international, multicenter, dose escalating phase i/ii study where patients receive 6, 3, 2 or 1 dose(s) of spc2996, a lna antisense molecule against bcl-2, over a period of up to 2 weeks, and are followed for 6 months.

Eligibility criteria:
inclusion criteria: * patients with relapsed or refractory chronic lymphocytic leukaemia requiring therapy * screening blood sample must show circulating lymphocyte count of more then 5 x 109/l and circulating lymphocytes expressing the phenotype cd5+cd20+cd23+. * the pcr bcl-2 m-rna level must be positive * the patients must be 18 years or older and have given informed consent. exclusion criteria: * previous treatment with rituximab, alemtuzumab or autologous stem cell transplantation within 6 months prior to visit 1 or allogeneic stem cell transplantation at any time * patients that received anti-cancer therapy, glucocorticoids or radiotherapy within 4 weeks prior to visit 1 and patients with known or suspected transformation of cll

Keywords: antisense, mrna antagonist, bcl-2, cll
a study of bgm0504 in participants with obesity

Conditions: Obesity

Summary: to evaluate the efficacy and safety of bgm0504 compared with tirzepatide in adult participants who have obesity without diabetes after 26 weeks of treatment.


Eligibility criteria:
inclusion criteria: * ● able and willing to provide a written informed consent. * male or female subjects, 18-65 years of age at the time of signing informed consent. * at screening visit, 35.0 ﹤bmi﹤ 45.0 kg/m2; * diet and exercise control for at least 3 months before screening visit, and be of stable weight (± 5%) self-reported change within the last 3 months. exclusion criteria: * ●history of chronic or acute pancreatitis. * history of severe drug allergy or specific allergic disease or severe allergies. * family or personal history of medullary thyroid carcinoma (mtc) or multiple endocrine neoplasia syndrome type 2(men-2). * history of malignant tumors \[except carcinoma in situ with no recurrence within 5 years (except for malignant melanoma in situ), skin basal cell carcinoma and squamous cell carcinoma\]. * suspected or confirmed history of alcohol or drug abuse; * any chronic infections likely to interfere with study conduct or interpretation such as hepatitis b (hbv), hepatitis c (hcv), human immunodeficiency virus (hiv) or treponema pallidum (tp). * donation or loss of 400 ml or more of blood within 3 months prior to screening, or blood donation during screening or within 3 months after the end of the trial. * pregnant or lactating woman. * any disorder, unwillingness, or inability not covered by any of the other exclusion criteria, which in the investigator's opinion, might jeopardize the participant's safety or compliance with the protocol.
diastolic dysfunction and atrial fibrillation in cabg surgery

Conditions: Heart Disease; Atrial Fibrillation

Summary: left ventricular (lv) diastolic dysfunction is a common manifestation of heart disease that is responsible for significant morbidity and mortality.it is present when the ventricular filling is impaired as a result of delayed relaxation or decreased compliance. during coronary artery bypass grafting (cabg) surgery, lv diastolic dysfunction is a frequent occurrence. failure of the left ventricle to dilate normally causes an increase in lv filling pressure. atrial fibrillation (af) is a common complication after cardiac surgery affecting 20-30% of patients undergoing coronary revascularization procedures. af is associated with significant morbidity and mortality and has been identified as a causative factor of increased length of both hospital and intensive care unit (icu) stay after cabg surgery, resulting in increased resource utilization and medical care costs.the primary aim of this study is to determine if patients with preoperative diastolic dysfunction are exposed to higher risk of af after coronary revascularization surgery.


Eligibility criteria:
inclusion criteria: * scheduled for elective cabg or opcab surgery * signed informed consent exclusion criteria: * patients with a history of previous heart surgery and/or undergoing valvular heart surgery. * patients with preoperative atrial fibrillation. * patients in whom tee is contraindicated.

Keywords: cardiac surgery diastolic dysfunction atrial fibrillation