Kornimate/medical-research-clean huggingface dataset:
dexamethasone and wound healing after thyroid surgery

Conditions: Wound Infection

Summary: dexamethasone is a potent glucocorticoid with analgesic and anti-emetic effects \[1-3\]. perioperative single-dose dexamethasone therapy has been used for several purposes: to reduce post-operative nausea and vomiting (ponv), pain and sore throat. there are also some reports on beneficial effects of less cardiac arrhythmia, improved appetite and less edema from glucocorticoids. preoperative small dose of dexamethasone was reported to prevent reversal laryngeal nerve injury and improve voice quality after thyroid surgery. while accepted wildly in clinical anesthesia practice, the immune-press related potential risks of side effects associated with dexamethasone, such as delayed wound healing, infection, as well as effects on blood sugar, make the use of perioperative single dose of glucocorticoid controversial. the effect of perioperative dexamethasone on wound healing varied with different types of surgery. the present study will observe the effect of dexamethasone on the safety of thyroid surgery.

patients who has the thyroid surgery for their thyroid cancer will be randomly allocated into two groups, either dexamethasone group or saline group. in the dexamethasone group, patients will receive 5mg dexamethasone iv right after general anesthesia induction while in the saline group, patients will have 1ml saline iv. the drainage fluid will be collected at 6 hours after surgery and on every morning after operation till the drainage tube is taken out. the total amount of drainage fluid and blood stain area in dressing will be collected and calculated after the operation. the c-reaction protein is checked in drainage fluid and in blood after operation. besides, the pain scores of incision pain and throat pain will be evaluated. postoperative nausea and vomit will be checked as well.

Eligibility criteria:
inclusion criteria: * elective total thyroidectomy or hemithyroidectomy with lymphadenectomy for thyroid cancer exclusion criteria: * age \> 65 years, \< 18 years * thyroid tumor with grave's disease * thyroid tumor size over 5 cm * second or more than 2 times for thyroid surgery * non-traditional pathway for thyroid surgery * asa \> ii * pharyngitis * smoking, alcohol drinking history * contraindication or long term use of dexamethasone (allege, ulcer bleeding history, et al)
is diverting ileostomy necessary in stapled ileoanal pouch?

Conditions: Ulcerative Colitis; Familial Adenomatous Polyposis

Summary: total proctocolectomy with ileal pouch anal anastomosis is the first choice surgical operation for management of ulcerative colitis and familial adenomatous polyposis. the addition of diverting ileostomy may reduce septic complications. in this randomized study the investigators compare two groups of patients with stapled ileoanal pouch one of them had diverting ileostomy and in the other this step is omitted.


Eligibility criteria:
inclusion criteria: * patients having total proctocolectomy with ileal pouch anal anastomosis. exclusion criteria: * hypoalbuminemia * prolonged steroid use * anemia * anastomosis under tension * leak with air test * bleeding * poor vascular supply of anastomosis

Keywords: total proctocolectomy with ileal pouch anal anastomosis with and without ileostomy
an open-label, single dose pharmacokinetic study of benefix (recombinant factor ix) in male chinese subjects with hemophilia b

Conditions: Hemophilia B

Summary: the sample size of 12 male chinese subjects are based on the cfda requirement for a china pk study and to support the registration in china.


Eligibility criteria:
inclusion criteria: * male chinese subjects 6 years or older (weight ≥20kg) with moderate to severe hemophilia b (factor ix activity ≤2%). * subjects should not have received an infusion of any factor ix products for at least 4 days before the administration of benefix on day 1. * subjects must be in a non-bleeding state before the administration of benefix on day 1. exclusion criteria: * evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at time of dosing) disease or clinical findings at screening. * diagnosed with any other bleeding disorder in addition to hemophilia b. * current fix inhibitor or history of fix inhibitor (defined as \> upper limit of normal (uln) of the reporting lab).
bacterial overgrowth associated with chronic multisymptom illness complex

Conditions: Gulf War Syndrome

Summary: the adverse impact of gulf war syndrome (gws) on the health of veterans and on the resources of the va healthcare system underscores the need to resolve its underlying cause. in response, the investigators propose to investigate the central hypothesis that gut bacteria may be responsible for symptoms associated with gws. the investigators will enroll a total of 120 patients with gws and 90 healthy controls.

the investigator will assess the prevalence and role of abnormal gut microbial fermentation among veterans with gws and investigate the efficacy of diagnostic and treatment strategies directed at indigenous gut microbes in the management of gws.

Eligibility criteria:
inclusion criteria: * gulf war veterans meeting the 1994 centers for disease control and prevention (cdc) criteria for the diagnosis of chronic fatigue syndrome(cfs), i.e \> six months of one or more symptoms from at least two of the following three clusters: general fatigue, mood and cognitive abnormalities, and musculoskeletal pain * must be under the care of a primary physician and have had a previous diagnosis of gulf war-related illness or gws and have medical records documenting investigations to rule out other causes of fatigue * minimum of the following laboratory screening tests: complete blood count with leukocyte differential, erythrocyte sedimentation rate, serum electrolytes, calcium, glucose, blood urea nitrogen, creatinine,urinalysis, and thyroid function tests * subjects must also have a gi consult first as part of routine care to confirm eligibility and availability * patients with irritable bowel syndrome (ibs), fibromyalgia (fm), anxiety or depression will not be excluded, but will be identified for subgroup analysis * healthy controls will be screened with complete blood count (cbc) and comprehensive metabolic panel to confirm eligibility exclusion criteria: * history of peptic ulcer, inflammatory bowel disease, diabetes, cirrhosis, rheumatoid arthritis, lupus, narcotic dependence,celiac disease, tropical sprue, bowel resection(including gastric, small bowel or colon; but gallbladder surgery or appendectomy are not exclusion criteria) * patients with chronic illness (hiv, tuberculosis) * pregnant or breast-feeding, psychotic depression, bipolar disorder, schizophrenia, eating disorders * healthy subjects will be excluded if their questionnaire indicated abnormal symptom profile

Keywords: chronic multisymptom complex small intestinal bacterial overgrowth gulf war syndrome chronic multisymptom illness complex
optical biopsy for thoracic lymph nodes.

Conditions: Mediastinal Lymphadenopathy; Non-small Cell Lung Carcinoma; Sarcoidosis

Summary: eus-fna is the recommended diagnostic examination of choice when patients present with suspected lower mediastinal lymph nodes on imaging. eus-fna is minimal invasive and low in costs, and although it has a good record in detecting diseases (eg confirm a nodal metastasis or granulomas) it has limitations in excluding diseases (missing metastases/ or granulomas) resulting in a false negative rate of 15-20%. substantial limitations that most likely can be attributed to areas within the node that are not sampled during eus-fna tissue acquisition. improved needle based ebus/ eus guided nodal diagnostics might result in improved quality of the fine needle aspirations, reduce in surgical diagnostic procedures , reduced costs and result in a shorter timebefore-treatment interval.

needle based confocal laser endomicroscopy (ncle) is a modern imaging technique, compatible with the conventional diagnostic aspiration needle, that uses an excitation laser light to create 'real-time' microscopic images of tissues. therefore this technique provides additional information regarding the nodal status and could therefore improve the diagnostic yield of eus-fna. specifically, we will describe the ncle image characteristics of lymph nodes involved in lung cancer and sarcoidosis as well as in healthy lymph nodes. improved characterization of mediastinal nodes might lead to improved diagnosis.

Eligibility criteria:
inclusion criteria: * ≥18 years of age * suspected or tissue proven sarcoidosis (stage i or ii based on ct/pet-ct) and referred for diagnostic endosonographic work up or * suspected or tissue proven nsclc with suspected mediastinal lymph nodes within reach of eus-fna exclusion criteria: * inability and willingness to provide informed consent * inability to comply with the study protocol * patients with known allergy for fluorescein * use of betablokker within 24 hours before procedure * possible pregnancy or lactating women
surgical treatment of hepatic hydatidosis in elderly patients

Conditions: Cystic Echinococcosis

Summary: cystic echinococcosis is a clinically complex chronic parasitic disease and a major socioeconomic problem in endemic areas. the safety of liver resection in elderly patients is often debated among medical professionals. the investigators analyzed the postoperative morbidity and mortality rates of elderly patients who underwent surgery at our unit.

retrospective observational study from prospective database focused on liver hydatidosis carried out at our hepato-pancreato-biliary surgery unit. the study period spanned from january 2006 to october 2020. the study was approved by the research ethics committee of our hospital. an informed consent from the patient was not required since the study was retrospective and observational, and entailed no risk. seventy years of age was the cutoff age to consider patients as elderly. inclusion criteria of patients: liver hydatid cyst (lhc) diagnosed by preoperative computed tomography (ct) or magnetic resonance imaging (mri) and pathological diagnosis after surgery, and lhc treated by total or partial pericystectomy. exclusion criteria of patients: emergency surgery and simple drainage of cyst.

Eligibility criteria:
inclusion criteria: * liver hydatid cyst (lhc) * pathological diagnosis after surgery * lhc treated by total or partial pericystectomy exclusion criteria: * emergency surgery and simple drainage of cyst
botox® intravesical instillation in participants with overactive bladder and urinary incontinence

Conditions: Urinary Incontinence; Overactive Bladder With Urinary Incontinence

Summary: this study will evaluate the efficacy and safety of botox® intravesical instillation in participants with overactive bladder and urinary incontinence.


Eligibility criteria:
inclusion criteria: * symptoms of oab (frequency/urgency) with urinary incontinence for at least 6 months * inadequate response or limiting side effects with pharmacotherapy for the treatment of oab exclusion criteria: * overactive bladder caused by neurological condition * patient has predominance of stress incontinence * history or evidence of pelvic or urological abnormality * prior use of botox for any urological condition
compassionate use (cu) of regn5458 for patients with relapsed or refractory multiple myeloma (mm)

Conditions: Multiple Myeloma

Summary: provide compassionate use' of regn5458 for patients with relapsed or refractory multiple myeloma

compassionate use requests are only being considered in response to individual patient investigational new drug (ind) applications.

Eligibility criteria:
inclusion criteria: - exclusion criteria: -

Keywords: relapsed, refractory
effects of aromatherapy on anxiety in invasive radiologic procedure

Conditions: Anxiety; Anxiety Preoperative

Summary: the purpose of this study is to see if using aromatherapy (lavender or bergamot) will lower anxiety in patients having invasive radiology procedures. first, the level of anxiety is assessed prior to the procedure using a questionnaire. then, patients are given the aromatherapy treatment during the pre-procedure period. then, the same questions are asked to determine how anxious the patient is after the aromatherapy and before going into the procedure room. after the procedure, patients are asked to evaluate the process of the study.


Eligibility criteria:
inclusion criteria: * scheduled for myelogram or ir invasive procedure at investigative site exclusion criteria: * incapable of giving informed consent * requiring pre-medication for scheduled procedure * allergy to lavender or bergamot * asthma (type of breathing related condition) * copd (chronic obstructive pulmonary disorder - breathing disease) * respiratory issues requiring oxygen therapy
chronic neck pain: mobility, sleep, function

Conditions: Pain; Neck

Summary: the goal of this observational study is to compare pain, cervical mobility, sleep quality, and functional status between individuals with chronic neck pain (cnp) and healthy individuals. the study focuses on understanding the complex relationships between these factors in individuals with cnp, with the aim of providing insights that could contribute to more effective rehabilitation strategies. the main questions it aims to answer are: * how pain, cervical mobility, sleep quality, and functional status differs between individuals with and without chronic neck pain? * what is the relationship between functional status and cervical mobility and sleep quality in individuals with chronic neck pain?


Eligibility criteria:
inclusion criteria: * age between 18 and 55 years. * chronic neck pain (cnp) persisting for longer than 3 months (for the cnp group). * volunteering participation in the study. * healthy controls, including relatives of cnp participants. exclusion criteria: * history of neck trauma or other cervical spine conditions (e.g., radiculopathy). * prior surgical interventions involving the head, face, cervical spine, upper or lower extremities, or cervical disc herniation. * degenerative spinal conditions. * use of analgesics, anti-inflammatory medications, or muscle relaxants within the previous week. * presence of rheumatological or cardiovascular diseases, chronic neurological or psychiatric disorders, substance abuse, anemia, or diabetes.

Keywords: pain neck range of motion sleep quality functional status
mechanical stimulation of the ovary for infertility treatment in patients with very low ovarian reserve

Conditions: Ovarian Stimulation

Summary: examine the possibility that mechanical stimulation and ovarian fragmentation in women with premature ovarian failure or low ovarian reserve intended for egg donation may cause early follicular recruitment and increase chances of achieving pregnancy through ivf.

the women will undergo a surgical laparoscopy during which one of the two technique will ensue. 1. one of the ovaries will be scratched ( 2 mm depth) with a knife. simultaneously, a piece of the ovary will be preserved for further histologic analysis and research in the laboratory. 2. a piece of one ovary will be resected (up to one third of the ovary's volume, without harming the other ovary. the resected ovarian tissue will be transferred immediately to the laboratory where the cortex will be divided from the medulla and sliced to small pieces of 1-2 square millimeters. these pieces will be transferred back to the operation room in order for them to be transplanted under the serosa layer of the remaining ovary. any bleeding would be stopped using a stiches or hemostatic mesh (diathermy will not be used). simultaneously, a piece of the ovary will be preserved for further histologic analysis and research in the laboratory. post operational follow up ( up to two years) including: menstrual cycle surveillance, hormonal profile, amh level, us of the pelvis and antral follicles count (afc). a month after the surgery, an ovarian stimulation will commence following ivf while close monitoring the ovarian response and comparing the pre and post operation response. moreover, the treated ovary will be compared to the untreated one: using the us the ovarian volume and antral follicles size and count will be evaluated. the preserved pieces of ovary will be histologically evaluated for ovarian reserve analysis. additionally, these pieces will be used for experiments for the evaluation of various methods for primordial follicles stimulation including mechanical stimulation like the laser or using substances like akt stimulators.

Eligibility criteria:
inclusion criteria: * healthy women, aged 21-40. with premature ovarian failure. * healthy women, with poor ovarian reserve, aged 38-45, undergoing ivf low ovarian response: recruitment of up to three eggs in previous treatments. * after the failure of at least 4 cycles. * two functioning ovaries, follicular and hormonal response of both ovaries in prior therapies. * women candidates for egg donation, and seeking further treatment before switching to egg donation. exclusion criteria: * women with kidney disease. * women with infertility factors other than ovarian failure, such as endometriosis, pcos, male factor. * women with one non-functioning ovary, or that was removed. * women with an intrauterine or pelvic pathology.

Keywords: mechanical laboratory ovarian stimulation poor responders
group therapy for depressed dementia caregivers

Conditions: Depression

Summary: depression in family caregivers of relatives with alzheimer's disorder and related dementias is a serious public health problem. this is a randomized, controlled, single-blind pilot clinical trial of depressed caregivers, to determine the efficacy and mechanisms of group therapy for depressed dementia caregivers.

the trial was designed to measure clinical outcomes including depressive symptoms and other secondary outcomes of caregivers of persons living with dementia. it also included magnetic resonance imagery scanning at baseline (prior to study group) and post group to identify candidate mechanisms of effects. notes related to outcome measurement. on 05.10.2017 (prior to participant enrollment), all secondary outcomes were approved by the ucsf irb #16-20163. it was noted in the irb that the primary outcome timepoint was to be obtained 4 weeks after the first group session. due to magnetic resonance imaging scanning scheduling constraints, which occurred at the same time as the 4 weeks visit, the outcome could not be exactly four weeks post the first group session but was collected approximately at this time. on 05.10.2017 (prior to participant enrollment), three-month post group secondary outcomes were also approved.

Eligibility criteria:
inclusion criteria: endorse clinically relevant baseline depressive symptoms primary caregiver for a relative with dementia exclusion criteria: age \< 45 meditation / guided imagery practice more than twice per week ideas of harming relative with dementia current violence towards relative with dementia adult protective services report on file primary psychiatric disorder other than unipolar major depression cognitive impairment on the part of the caregiver (mini mental state examination score less than 24) unstable medical illness planned surgery active drug or alcohol abuse inability to understand written and oral english.
bronchodilators and respiratory mechanics in chronic obstructive pulmonary disease (copd) patients

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the aim of this study is to assess the effects on respiratory mechanics of one "classical" short-term bronchodilator (i.e., salbutamol) versus placebo, and to verify the hypothesis that the addition of another bronchodilator (i.e., anticholinergic) may induce a further improvement on the work of breathing of stable copd patients.

studies with long-acting b2-agonists in copd patients who poorly respond to routine airways obstruction reversibility tests with forced expiratory manoeuvres, such as forced expiratory volume in one second (fev1), are scarce. such studies, however, seem to show favourable effects on clinical parameters. this may explain the subjective improvements and changes in quality of life with long-acting b2-agonists in patients with copd. the lack of effect on forced expiration tests may be due to early airway collapse and subsequent airflow decline causing underestimation of the existing bronchodilatory effects located more peripherally in the respiratory tract, where the major site of resistance is located in obstructive lung disease. we therefore design a study aimed to assess the short term effects of one short-acting beta2-agonist vs placebo, and the effects of an additional and sequential administration of a different bronchodilator, like tiotropium bromide (anticholinergic agent) on the work of breathing, and its components (i.e., lung resistances and compliance) of copd patients with poor reversibility assessed using the classical pulmonary function tests.

Eligibility criteria:
inclusion criteria: * copd patient with a tiffenau ratio \ 25% predicted * poor reversibility to an acute bronchodilator test (i.e. fev1 changes\<10% from baseline) exclusion criteria: * lack of informed consent * cancer * concomitant lung and airways diseases

Keywords: copd respiratory mechanics bronchodilators copd patients with poor reversibility
study of an essential oil and a delmopinol mouthrinse effect on dental plaque accumulation index, gingivitis index and on streptococcus mutans, lactobacillus, aerobic and anaerobic oral bacteria colony counts.

Conditions: Gingivitis; Dental Plaque Accumulation

Summary: the use of mouthrinses may be of relevance as a complement to daily dental hygiene procedures, especially for patients who do not comply with a proper mechanical removal of dental plaque. essential oils and delmopinol mouthrinses are effective to reduce dental plaque accumulation and gingivitis. also an effect on dental bacteria can be found. the study hypothesis states that there are no differences between the mouthrinses on the reduction of gingivitis and dental plaque accumulation as well on the bacterial counts of streptococcus mutans, lactobacillus, aerobic and anaerobic bacteria.


Eligibility criteria:
inclusion criteria: * patient at the dental hygiene clinic of faculdade de medicina dentária * signature of consent form * have, at least, two quadrant with 6 teeth each * gingival index at baseline less than 3 * presence of dental plaque exclusion criteria: * use of a mouthrinse * dental hygiene appointment in the past 6 months * use of antibiotics in teh past 3 months * presence of extensive caries and fractures of teeth

Keywords: clinical trial prevention mouthrinse
ultrahypofractionated, adaptive radiation therapy of prostate cancer

Conditions: Prostate Cancer; Adaptive Radiotherapy; Quality of Life

Summary: in this prospective, multi-center cohort study, the tolerability and quality of life during ultrahypofractionated radiotherapy (rt) of early stage prostate cancer is surveyed at several institutions in germany. radiotherapy is delivered by an online-adaptive rt device (varian ethos), which is able to correct daily variations in anatomy and to adjust the irradiation plan accordingly. a digital patient questionnaire is used to asses quality of life longitudinally. quality of life (qol) and toxicity profiles will be correlated with planning parameters and compared to retrospective cohorts of patients who underwent normofractionated rt or moderately hypofractionated rt, respectively.


Eligibility criteria:
inclusion criteria: * no androgen deprivation therapy within the last 2 months prior to rt * good performance status (eastern cooperative oncology group, ecog, 0/1) * no secondary malignancy

Keywords: adaptive radiotherapy quality of life ultra-hypofractionation