Kornimate/medical-research-clean huggingface dataset:
effects of cardiopulmonary bypass (cpb)-leukocyte filtration on interleukins serum levels and pulmonary function

Conditions: Systemic Inflammatory Response Syndrome (SIRS); Leukocyte Disorders; Complications Due to Coronary Artery Bypass Graft

Summary: to test the hypothesis that leukocyte filtering during cardiopulmonary bypass (cpb) might reduce the inflammatory response and protect the lungs against the acute injury

background and objectives: the extension of the systemic inflammatory response observed after cardiopulmonary bypass (cpb) in cardiac surgery is associated to postoperative pulmonary dysfunction degree. the leukocyte depletion during cpb can modify that response. the aim of this study was to evaluate the effects of leukocyte filtering on the inflammatory response and lung function in patients undergoing coronary artery bypass grafting. methods: after approval by the institutional ethical committee, a prospective randomized study was performed to compare nine patients undergoing coronary artery bypass grafting (cabg) using leukocyte filtration in the arterial line (lg-6, pall biomedical products) and eleven others submitted to standard cpb. chest ct, oxygenation analysis and a complete leucocyte count were performed before surgery. after intravenous anesthesia induction, patients were mechanically ventilated with tidal volume of 8 ml.kg-1, with fio2 0.6, and peep of 5 cm h2o, except during cpb. haemodynamic data, pao2/fio2, shunt fraction, interleukins, elastase and myeloperoxidase were evaluated before and after cpb, at the end of surgery, 6, 12 and 24 hours after surgery. chest ct was repeated on the first postoperative day. data were analyzed using two-factor anova for repeated measures.

Eligibility criteria:
inclusion criteria: * patients undergoing coronary artery bypass grafting (cabg), having their physical state classified as pii and piii, according to the american society of anesthesiologists (asa). surgical risk was stratified according to parsonnet criteria, and only patients considered low to moderate risk were admitted. exclusion criteria: * subjects older than 70 years * body mass index (bmi) over 35 kg/m2 * congestive heart failure (chf) greater than class iii (nyha) * left ventricle ejection fraction less than 40% * submitted to recent surgery * creatinine ≥ 1.4 mg / dl or in use of oral anticoagulants were excluded

Keywords: coronary artery bypass surgery cardiopulmonary bypass leukocyte reduction filtrations pulmonary function systemic inflammatory response
ecaa brain mri: seeking the link between extracranial carotid artery aneurysms and small vessel disease

Conditions: Extracranial Carotid Artery Aneurysm

Summary: in order to understand which ecaa patients benefit from medical therapy, more should be known about the possible outcomes of this rare disease. small vessel disease seen on brain mri's could be a good marker to assess possible silent cerebrovascular disease caused by ecaa's, suggesting underlying generalized vascular disease. with this knowledge, medical therapy for ecaa patients can be optimized and individualized to treat possible generalized vascular disease, aiding physicians in choosing a treatment strategy.

the ecaa brain mri study is a monocenter longitudinal observational cohort study, initiated by the department of vascular surgery at the university medical center utrecht (umcu), the nederlands. the study aims to recruit 50 participants with an extracranial carotid artery aneurysm (ecaa) who are currently receiving conservative treatment. patients will undergo mri at baseline and after 2 years of follow-up. the expected duration of the study is approximately 3 years. the study will be conducted according to the principles of the declaration of helsinki (64th wma general assembly, fortaleza, brazil, october 2013). the medical ethics committee of the umcu has approved the study. to be eligible to be included in the ecaa brain mri, patients must be enrolled in the carotid aneurysm registry (car, nct02229370)

Eligibility criteria:
inclusion criteria: * patient older than 18 years registered in the car treated with conservative therapy * willingness and ability to participate in all scheduled procedures outlined in the protocol * understanding of the dutch language * patient is able and willing to give informed consent. exclusion criteria: * inclusion criteria are not met * subjects registered in the car that have undergone surgical or endovascular treatment of the ecaa * contradictions for mri, such as 1) metallic objects in or around the body (e.g. cardiac implantable electronic device such as pacemakers and implantable cardioverter defibrillators (icd); 2) claustrophobia, 3) pregnancy. * other major neurological or psychiatric conditions affecting the brain and interfering with the study design (e.g. multiple sclerosis, epilepsy, parkinson's disease, vascular dementia) * unable to read or write the patient information letter and broad consent file * patients who have a life expectancy of less than two years due to a pre-existing condition e.g. cancer
effectiveness of placental drainage in the third stage of labor: a randomized clinical trial

Conditions: Management of Delivery

Summary: the purpose of this study is to determine if placental drainage shortens third period of labor and reduces postpartum blood lost.

the study aims to compare the effectiveness of placental drainage versus maintenance of maternal cord clamped end in the third stage of labor to reduce postpartum blood loss.

Eligibility criteria:
inclusion criteria: * low risk pregnant women * pregnancy at term * women at low risk for assisted labor / delivery and postpartum care. * live fetus exclusion criteria: * women under 18, mentally handicapped and indigenous; * women who agreed to participate signed the informed consent, but evolved to cesarean section or instrumental delivery by forceps; * instrumental delivery by forceps or c-section

Keywords: drainage pregnancy active management postpartum hemorrhage
morphine titration by patient self-controlled by a mechanical device versus administration by the nurse for patients with severe acute pain in the emergency department

Conditions: Acute Pain

Summary: intense acute pain is a common reason for emergency admittance and its management is one of the major public health goals. in the recommendations formalized experts, it is recommended to use a protocol titration with morphine bolus of 2 mg (for patients less than 60 kg) or 3 mg (for patients over 60 kg) repeated every 5 minutes with a target of the visual analog scale less than or equal to 30. despite these specific recommendations and a broad awareness of the teams, management of pain remains to be improved, the major difficulty of morphine titration at the emergency department being the availability of paramedical personnel to perform revaluations and reinjection. thus, effective analgesia would be obtained in 50% of cases to 30 minutes. the investigators want to study the self-controlled morphine titration by the patient by a mechanical device for single use (efficacy/safety).


Eligibility criteria:
inclusion criteria: * admission to an emergency department * acute pain (visual analog scale \> 60) * able to assess pain using the numerical scale * prescription of morphine titration exclusion criteria: * physical or mental disorders limiting the understanding and / or use of a pca * history of allergy to morphine / hypersensitivity to any component * long-term treatment morphine * opioid therapy administered prior to inclusion * analgesic treatment level 2 (codeine, tramadol, nefopam ...) administered prior to inclusion or planned * history of substance abuse * severe respiratory insufficiency * severe hepatic impairment * head trauma * intracranial hypertension * uncontrolled epilepsy * pregnant or lactating * patient jailed * incapacitated adult under guardianship * incapable of giving informed consent

Keywords: pain analgesia morphine pca nurse
covid-19 and the brain

Conditions: Covid19; Brain; Neurocognition; fMRI

Summary: the main objective of this project is: 1. to assess the impact of covid-19 on the brain and executive functioning. twenty adult subjects of uz brussels (volunteers), who needed intensive care due to covid-19 (n=10) or exhibited mild symptoms due to covid-19 (n=10), will be recruited after hospital discharge. after signing an informed consent the subjects will undergo brain scans (t1, dti, swi, dwi, flair mri and rsfmri), an emotion regulation task and a neurocognitive test battery. the latter test battery will be performed using an ipad and will test different neurocognitive functions such as memory, abstract thinking, spatial orientation and attention. the duration of the test battery is 18min. the total duration of one trial is estimated at one hour and a half. all tests are planned at the department of radiology-magnetic resonance (uz brussel). after three months patients will visit the department of radiology-magnetic resonance a second time for the same experimental trial. additionally, a matched control group (n = 20; non covid or icu patients) will be included and undergo the same tests in order to compare the results of the brain scans, emotional regulation task and neurocognitive test battery with results of both covid-groups. next to objective data, questionnaires will be filled out, i.e. visual analogue scales of mental and physical fatigue, profile of mood states and some additional return to work questions.


Eligibility criteria:
inclusion criteria: * adult patients of uz brussels, who left the hospital and needed intensive care * adult patients of uz brussels, who left the hospital and exhibited mild symptoms * healthy volunteers (who never had covid-19) * ability to give informed consent * dutch or french speaking exclusion criteria: * history of neurological diseases
"overlap syndrome and psc: evaluating role of gut microflora and its identification with antibiotics in children"

Conditions: Primary Sclerosing Cholangitis; Autoimmune Hepatitis; Overlap Syndrome

Summary: based upon the possible implication of microbiota and abnormal microbial metabolites such as altered bile acids, in the pathogenesis of psc, emerging data suggests that oral antibiotics, such as vancomycin and metronidazole, may have therapeutic effects in this overlap syndrome or psc. the goal of our study is to evaluate role of antibiotics and microflora in children with aih/psc overlap syndrome or with psc alone. the investigators hope to learn what effects oral antibiotics has on the bacteria present in stool, and hope to learn to characterize human intestinal microbial communities, in children suffering from overlap syndrome or psc. the hypothesis of the investigators is that overlap syndrome and psc develop due to altered microflora and the resulting abnormal bile acids pool. the outcome of overlap syndrome or psc could be affected by presence or absence of rcuh. antibiotics to correct the microflora may result in disease/cholangiopathy remission.

the used antibiotic is metronidazole (flagyl), during 14 days, as induction therapy or rescue therapy. study participants will provide blood and stool samples in order to evaluate bile acids profile and microbiome, before and after the course of metronidazole, and then comparison will be made pre- and post-antibiotics. the investigators will determine the benefit of oral metronidazole therapy through improvement of clinical symptoms and improvement of liver function tests.

Eligibility criteria:
inclusion criteria: * children diagnosed with overlap syndrome, overlap syndrome + ulcerative colitis (uc), primary sclerosing cholangitis (psc) or psc + uc * children for whom consent is available * children under regular follow-up * children with at least one liver biopsy (for overlap syndrome patients) * children with at least one liver biopsy and one mrcp (for psc patients) exclusion criteria: * death * patients older than 18 years old at the time of diagnosis of liver disease
asymmetrical recovery of cone outer segment tips and foveal displacement after macular hole surgery

Conditions: Macular Hole

Summary: evaluation of asymmetry in recovery of cone outer segment tips and foveal displacement after macular hole surgery


Eligibility criteria:
inclusion criteria: * the patients with macular hole exclusion criteria: * the patients with follow-up less than 6 months

Keywords: cone outer segment tips line, foveal displacement
study of dentoxol® mouthrinse for oral mucositis

Conditions: Oral Mucositis

Summary: the primary objective of this study is to determine the efficacy of dentoxol® mouthrinse in reducing the severity of oral mucositis secondary to radiation therapy for head and neck cancer.


Eligibility criteria:
inclusion criteria: * planned to receive radiation therapy for cancer of the oral cavity, oropharynx, nasopharynx, hypopharynx or larynx, with or without concomitant chemotherapy. * planned to receive at least 5000cgy radiation therapy to at least 2 of 12 pre-specified areas in the oral cavity exclusion criteria: * unable to give written informed consent * known allergy/intolerance to any component of the study rinse or placebo * planning to use any contraindicated medications during the study period (pain medications are allowed) * age below 18 years * pregnant or nursing (if the patient is a woman of childbearing potential, a pregnancy test must be performed within fourteen days before enrollment in the study)

Keywords: mucositis
safety and efficacy of lumiracoxib in patients with osteoarthritis and with controlled hypertension

Conditions: Osteoarthritis; Controlled Hypertension

Summary: this study will investigate the effect on ambulatory blood pressure of lumiracoxib 100 mg once daily versus ibuprofen 600 mg three times a day in osteoarthritis patients with controlled hypertension.


Eligibility criteria:
inclusion criteria: * osteoarthritis of the hand, hip, knee or spine * high blood pressure (\<140/ 90 mmhg) which is controlled by antihypertensive medication(s). exclusion criteria • evidence or history of any cardiac and cerebral thrombotic/ ischemic diseases and/ or events other protocol-defined inclusion/exclusion criteria may apply

Keywords: osteoarthritis, hypertension, lumiracoxib, ibuprofen, 24-hour blood pressure profile
dat'aids prevention

Conditions: HIV Prevention

Summary: dataids prevention is a cohort study of hiv prevention in over 23 hiv sites in france including overseas, aiming to describe hiv prevention in every aspect including hiv screening, sti and hepatitis screening, post-exposure prophylaxis and pre-exposure prophylaxis


Eligibility criteria:
inclusion criteria: * male and female over 18 years old, * hiv negative * attending for : * hiv screening * hepatitis screening * sti screening / treatment * blood, body fluid or sexual exposure * post-exposure prophylaxis * pre-exposure prophylaxis * signed consent exclusion criteria: * hiv-infection * refusal to participate
cerebral perfusion during neonatal cardiac surgery

Conditions: Congenital Heart Defects; Hypoplastic Left Heart Syndrome; Aortic Coarctation

Summary: neonates with a congenital heart defect are often in need of early cardiac surgery. in complex congenital heart defects, cardiopulmonary bypass is usually employed, with or without deep hypothermic circulatory arrest (dhca). the brain is especially vulnerable to ischemic injury, which puts neonates undergoing complex operations at high risk of neurodevelopmental disorders. selective antegrade cerebral perfusion (acp) instead of dhca during these complex operations may contribute to less cerebral damage, but literature is not conclusive on this issue. therefore, the investigators will perform a randomised controlled trial comparing dhca and acp in neonatal aortic arch reconstructions, focusing on cerebral damage and neurological outcome.


Eligibility criteria:
inclusion criteria: * aortic arch reconstruction (diagnosis of hypoplastic left heart syndrome, hypoplastic aortic arch, severe coarctation and/ or interrupted aortic arch) * infants \<4 months old exclusion criteria: * anticipated arch reconstruction time longer than 60 minutes * sedation and intubation especially for the pre-operative mri-scan of this research project * participation in another clinical trial * failure of data collection

Keywords: congenital heart disease cardiopulmonary bypass neonatal brain injury deep hypothermic circulatory arrest antegrade cerebral perfusion
biomarkers in prehospital prediction of need for neurosurgical observation or intervention in tbi patients

Conditions: Traumatic Brain INjury

Summary: the pretbi ii study aims to investigate the diagnostic potential of prehospital s100b and gfap measurements in prediction of need for neurosurgical observation and/or intervention in moderate tbi patients, to rule-in high-risk patients. ultimately to select patients who will benefit from neuro surgical expertise in specialized departments and thereby possibly better patient outcome. hopefully also minimize treatment delay, secure optimal resource consumption and streamline patient courses by predicting the presence of neurotrauma. hypotheses: 1. a prehospital serum s100b level \> 0,10 microgram/l and expectedly above a certain and currently unknown cut-off value indicates the need for neurosurgical observation and/or intervention in moderate tbi patients. 2. a prehospital serum gfap level above a certain and currently unknown cut-off value can significantly predict a need for urgent neurosurgical observation and/or intervention in moderate tbi patients. 3. biomarker dynamics between prehospital and in-hospital biomarker values of s100b and gfap can significantly predict a need for urgent neurosurgical observation and/or intervention. 4. biomarker dynamics between prehospital and in-hospital biomarker values of s100b and gfap can significantly predict hospital course and outcome of patients with moderate tbi.


Eligibility criteria:
inclusion criteria: * patients presenting with glasgow coma score (gcs) gcs 9-13 suffering relevant trauma and displaying relevant clinical indices compatible with tbi as evaluated by ems staff. patients are considered incompetent due to on-going alteration of mental state. exclusion criteria: * patients \ 6 hours elapsed after trauma, unknown time of trauma, multi trauma, known dementia, chronic psychosis or active central nervous system (cns) pathology.

Keywords: biomarker point-of-care analysis
effect of lavender on sleep quality and insomnia severity in patients

Conditions: Insomnia, Psychophysiological

Summary: today, psychophysiological insomnia is the most common persistent insomnia. lavender essential oil is frequently used in the literature as an aromatherapy method to improve sleep quality. studies have found that lavender improves sleep quality. they also emphasized that more studies are needed in this area. when the relevant literature is reviewed, no studies examining the effects of lavender oil on patients with psychophysiological insomnia were found. in this context, the aim of the study was to evaluate the effect of lavender on sleep quality and insomnia severity in patients with psychophysiological insomnia.

today, psychophysiological insomnia is the most common persistent insomnia. the patient's inability to sleep occurs as a result of repetitive negative thoughts such as the thought that he will have difficulty sleeping before going to bed and/or past experiences involving the bedroom or the night. more effort to sleep causes more wakefulness and more difficulty falling asleep. numerous studies have shown that insomnia seriously affects health and quality of life and can cause various problems including memory problems, depression, irritability, cardiovascular and cerebrovascular diseases, etc. therefore, looking for effective ways to improve sleep quality is important for individual and social health. today, drug therapy, psychotherapy, physiotherapy and cognitive-behavioral therapy are widely used treatments for insomnia. recently, more and more studies have found that aromatherapy is one of the non-drug treatments to improve sleep quality. lavender essential oil appears in the literature as an aromatherapy method frequently used to improve sleep quality. studies have found that lavender improves sleep quality. they also emphasized that more studies are needed in this area. when the relevant literature was examined, no studies were found examining the effects of lavender oil on patients with psychophysiological insomnia. in this context, the aim of the study was to evaluate the effect of lavender on sleep quality and insomnia severity in patients with psychophysiological insomnia.

Eligibility criteria:
inclusion criteria: * being 18 years of age or older, * being over 65 years old * being diagnosed with psychophysiological insomnia, * knowing turkish at a level that will allow you to read and understand the survey questions, * accepting to participate in the study exclusion criteria: * having a serious physical or cognitive disability that would prevent him/her from answering the survey, * being under the age of 18, * not accepting to participate in the study, * being allergic to lavender, * having a chronic additional disease related to the respiratory system, * having a psychiatric or neurological additional disease, * using medication(s) that may affect sleep, * experiencing a physical activity limitation that causes bedriddenness, * having or contracting a disease that will affect the ability to smell.

Keywords: insomnia sleep quality sleepiness lavender
omega-3 fatty acids for treatment of depression in adolescents

Conditions: Depression

Summary: adolescence is the highest risk period for depression onset. more than 1.3 million youths suffer from major depression annually in the united states, and there is evidence for an increasing trend. because many adolescents have their first depressive episode in adolescence and adolescent depression often leads to recurrent mood disorders in adults, effective treatment during early illness can minimize the negative consequences of initial and repeated episodes. although some antidepressants (particularly selective serotonin reuptake inhibitors (ssris)) are effective treatments for juvenile depression, recent warnings about suicide and the use of ssrls highlight the need for new and safe treatment for juvenile depression. data in adults suggest that supplementation with polyunsaturated fatty acids (pufa) might be useful for the treatment of depression. the purpose of this study is to investigate the safety and efficacy of pufa for the treatment of adolescent depression.


Eligibility criteria:
inclusion criteria: 1. adolescents between the ages of 13 and 21 currently under standard of care treatment at the child division of the department of psychiatry at csmc 2. diagnosed with major depressive disorder using the dsm-iv diagnostic criteria exclusion criteria: 1. active suicidal ideation, with a current plan and/ or a recent suicide attempt 2. severe psychotic symptoms (presence of distressing or common hallucinations and/ or delusions) 3. history of bipolar disorder, eating disorder, schizophrenia, schizoaffective disorder, or autism 4. potential subjects using psychotropic medication(s), alcohol, and/ or drugs within 2 weeks prior to entry into the study (8 weeks for fluoxetine and maois - monoamine oxidase inhibitors) 5. pregnant or lactating females, or those who are not using a medically accepted means of contraception (defined as oral contraceptive pill or implant, condom, diaphragm, spermicide, iud, s/p tubal ligation, partner with vasectomy) and become pregnant 6. seizure or other neurological disorders 7. dermatological conditions 8. unstable cardiac, pulmonary, endocrine, or renal disorder 9. adolescents who are currently being effectively treated with antidepressants

Keywords: adolescent depression depression teenage depression los angeles