Kornimate/medical-research-clean huggingface dataset:
effect of a program of deep inspiration combined to expiratory positive airway pressure in asthmatic

Conditions: Improvement of Functional Capacity.; Improvement of Quality of Life.; Improvement of Cardiovascular Autonomic Control.

Summary: the purpose of this study is to determine the effects of a deep inspiration combined to expiratory positive airway pressure protocol on respiratory function, quality of life, exercise tolerance and heart rate variability in adults with severe asthma.

asthma is associated with high morbidity and significant mortality. this disease has functional impact on activities of daily living (adls) and according to some studies in the united states and europe, the percentage of asthmatics who have significant restrictions in their adls is quite significant. asthma is characterized as a major public health problem, not only in brazil but worldwide. currently there are few studies reporting the effects of a domiciliary program of deep inspiration associated with positive expiratory pressure in the airways of asthmatics. this study aims to analyze the benefits of this program on lung function, quality of life and response to exercise.

Eligibility criteria:
inclusion criteria: * age between 20 and 80 * severe asthma exclusion criteria: * disagreement with consent form * other respiratory disease * acute severe asthma * pregnancy or breastfeeding * current smoking * lack of capable of conducting the study visits
magnesium sulfate versus ipratropuim bromide in acute exacerbation of chronic obstructive pulmonary disease

Conditions: COPD Exacerbation

Summary: treatment with short acting β2 agonists for exacerbations of copd results in clinical improvement. it has not been established whether combining short acting β2 agonists to other bronchodilators is more effective than β2 agonists alone. the aim of this study is to evaluate the efficacy and safety of combination of saba and mgso4 in comparison to saba and ipratropium bromide (ib) in patients attending the emergency department for aecopd.

patients presenting to the emergency department with exacerbation of copd are randomized to receive nebulised ipratropuim bromide or combined nebulised and an intravenous bolus of magnesium sulfate during 1 hour.

Eligibility criteria:
inclusion criteria: * 40 years old or over * have known or suspected copd based on pulmonary function test, arterial blood gas, clinical history, physical examination, and chest radiograph * worsening of dyspnea within 2 weeks, * partial pressure of arterial carbon dioxide (paco2) \>45 mmhg * respiratory rate \>24/min * arterial ph \<7.35 * partial pressure of arterial oxygen (pao2) \<50 mmhg under room air exclusion criteria: * hypersensitivity to anticholinergics and to magnesium sulfate * patients that received anticholinergics within 6 hours before ed admission * systolic arterial pressure \<90 mmhg or need to vasoactive drugs

Keywords: copd exacerbation magnesium sulfate ipratropium bromide emergency departement
a safety and pharmacokinetic study of cvx-096 in type 2 diabetics

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of this study is to determine safety and tolerability of cvx-096 in adult, type 2 diabetic patients.


Eligibility criteria:
inclusion criteria: * male and/or female patients (females will be women of non-childbearing potential) with an historical diagnosis of type 2 diabetes mellitus, who are currently being treated with metformin at a dose at or near maximum. * hb a1c between 7-10%. * fasting c-peptide \>0.4 nmol/l. exclusion criteria: * history of clinically significant chronic conditions other than t2dm not well controlled by either diet or medications. * patients with pancreatitis or considered a high risk for pancreatitis. * history of contraindications to metformin therapy. * previous treatment with an approved or investigational glp 1 mimetic.

Keywords: phase 1 type 2 diabetes cvx-096 diabetes mellitus adult-onset diabetes mellitus non-insulin dependent
integral single-cell landscape of immunological hallmarks for ankylosing spondylitis

Conditions: Ankylosing Spondylitis

Summary: three hla-b27-positive health donors (hds) with matching age were enrolled via genetic screening, and fourteen as patients were recruited at fujian provincial hospital from may to july 2021. all as patients satisfied the modified new york (ny) criteria, and the categorization of three disease groups (ea, ld and rm) was according to clinical hallmarks and imaging evidences. the five patients in the ea group were in the early stage of disease, showing obvious symptoms, and had not yet received standard treatments, including various nsaids and dmards. the five patients in the ld group were all disabled, and confirmed by radiographic evidence of structural damage in hip joints and spinal deformity. the four patients in the rm group received standardized treatment under the guidance of specialist doctors, and maintained clinical remission and normal laboratory indicators for over six months. patients in both ea and rm groups were confirmed to have no structural damage or deformities by radiographic evidences.


Eligibility criteria:
inclusion criteria: clinical diagnosis of ankylosing spondylitis clinical hallmarks and imaging evidences exclusion criteria: pregnant patients other diseases, tumors and injuries
prevention of pressure sores in the prone position in ards patients

Conditions: Pressure Sores

Summary: a nursing strategy to prevent pressure sores in the prone position in acute respiratory distress syndrome (ards) patients. a multicenter controlled prospective stepped wedge trial.


Eligibility criteria:
inclusion criteria: * 18 years or more in age * staying in intensive care unit (icu) * intubated * mechanically ventilated * severe ards defined as arterial pressure in oxygen (pao2)/ oxygen inspired fraction (fio2) \< 150 mmhg with positive end-expiratory pressure (peep) ≥ 5 cmh2o and fio2 ≥ 0.60 * prone positioning indicated by the clinician in charge * weight \< 140 kgs * agreement to participate obtained from the confidence person of the patient * affiliated to social protection insurance exclusion criteria: * contra-indication to the prone positioning * prone positioning before inclusion * person under legal protection * pregnancy * weight \> 140 kg * tracheotomy * extracorporeal membrane oxygenation (ecmo) * refusal to participate
clinical validation of bactec™ plus aerobic/f culture vials compared with equivalent product

Conditions: Sepsis

Summary: this study is a multi-center, randomized clinical validation. subjects should be fully informed of this protocol and related risks, and can only be enrolled into this study after signing the informed consent form. blood collection of the subjects at the same puncture point at a single site will be injected into the test vial and the control vial respectively, and the vials will be transferred to the bactec system for culture and the results will be observed. after the bactec system incubation completion, the vials will be subcultured. strains grown on plates will be identified using appropriate methods and, if possible, at the species level.


Eligibility criteria:
inclusion criteria: * subject is willing to provide written informed consent to sponsor. * blood specimens * patients with suspected blood infection that have one or more of the following characteristics : a) body temperature \> 38°c or body temperature \ 10.0×109/l, especially if there is a "left shift") or decrease (count \ 20 beats/min or arterial partial pressure of carbon dioxide (paco2) \ 90 beats/min; f) mucocutaneous hemorrhage; g) coma; h) multi-organ dysfunction; i) decreased blood pressure; j) elevated inflammatory response parameters such as c-reactive protein or hypersensitive c-reactive protein, procalcitonin (pct), 1,3-β-d-glucan (g test), etc. exclusion criteria: * subjects have been enrolled in this study and samples have been collected * patients with severe and very severe anemia (last hemoglobin \<60g/l within seven days) * females with known pregnancy
expression and sequence of calcium channels in non-small cell lung carcinoma (nsclc)

Conditions: NSCLC

Summary: calcium is an extremely important ion used in our body for many processes. one of its tasks is to control gene expression. cells intake calcium from their surroundings though special calcium channels located on the surface membranes of the cells. the great many studies on such calcium channels were performed on excitable cells such as muscle, heart or neuronal cells, where the calcium ions are controlled by voltage. surprisingly, not much is known about the identity of calcium subunits in non-excitable cells like epithelial cells (which compose most of the connective tissue in the body), liver cells, lung cells, immune system cells, etc. recently, the investigators have shown that calcium channels from muscles are, in fact, expressed in t cells of the immune system, where they are used for proliferation. the investigators postulated that probably other cell types, especially cancerous cell types, might be using these subunits similarly. the aim of this study is to determine the identity and sequence of calcium subunits expressed in non-small cell lung carcinoma (nsclc), which accounts for 80% of the worldwide lung cancer deaths.

initial examination of nsclc cell lines determined that they express the mrna of voltage gated calcium subunits, found normally in neurons. furthermore sequence analysis of these subunits has shown that modifications have occurred. the aim of the study in nsclc patients is to sequence and clone the calcium channel subunits expressed in their tumor. expression and sequence will be compared between the normal and cancerous lung tissue for each patient.

Eligibility criteria:
inclusion criteria: * nsclc patients * patients without nsclc * men or woman between 18-80 years of age exclusion criteria: * pregnant woman

Keywords: expression of l-type calcium subunits
pocket sized carotid stenosis screening by junior doctors

Conditions: Ischemic Attack, Transient; Transient Ischemic Attack; Stroke; Cerebrovascular Accident; Cerebrovascular Apoplexy

Summary: among patients admitted with cerebral ischemia (stroke and transitory ischemic attack (tia)) it is important to reveal the underlying cause of the disease. in special it is important to reveal if carotid artery stenosis is present as such a finding will directly influence on treatment and follow-up. for the diagnosis of carotid artery stenosis due to atherosclerosis ultrasound examinations is the cornerstone, but computer tomography and magnetic resonance imaging may be better in some cases. development of high quality pocket-sized ultrasound scanners has allowed for semi quantitatively bed-side assessment of the carotid arteries and the heart. the investigators aim to study the feasibility and reliability of bed-side assessment of the carotid arteries by pocket-sized ultrasound scanners in inexperienced hands and the clinical influence of this examination when performed by experienced users. the investigators hypothesize that a significant proportion of this patient population can be clarified bed-side by junior doctors with no need of further imaging procedures for the assessment of the carotid arteries and the heart.

population: approximately 100 patients admitted to the department of medicine, levanger hospital and stroke department, st. olavs hospital with history and findings suspicious of stroke/transitory ischemic attack (tia). informed consent mandatory. exclusion criteria: ct angiography of carotid vessels performed after index event, unless all participating clinicians are fully blinded to the results. hypotheses: the carotid arteries can be assessed bed-side by pocket-size ultrasound scanners with high feasibility and reliability by junior doctors with limited training. bed-side assessment of the carotid arteries by pocket-size ultrasound scanners may reduce the need for more advanced (higher cost) imaging procedures. new high frame rate tracking doppler can increase accuracy and reproducability of stenosis grading. methods: pocket-size imaging device from ge ultrasound, commercial available. approved for clinical use. high-end carotid doppler ultrasound by high-end equipment (ge vivid 9) and computer tomography and magnetic resonance imaging at the department of radiology, levanger hospital and st. olavs hospital verasonics research scanner for high fram rate imaging

Eligibility criteria:
inclusion criteria: * admitted to the department of medicine with history and findings suspicious of (transient) cerebrovascular ischemia and willing and able to give their informed written consent exclusion criteria: * evaluation of carotid artery stenosis by imaging (ct, mri or ultrasound) performed during the stay prior to inclusion.

Keywords: hand-held ultrasound diagnosis carotid artery stenosis
a study intravitreal thn391 in diabetic macular oedema secondary to non-proliferative diabetic retinopathy.

Conditions: Diabetic Macular Edema; Diabetic Retinopathy

Summary: thn391-opt-101 is a study assessing safety and preliminary efficacy of thn391 in patients with diabetic macular edema (dme) given as monotherapy.

this is an open label, multiple ascending dose (mad) study, in which the safety of thn391 will be assessed in escalating doses. this study will enroll a total of approximately 21 participants into 3 sequential dose-escalating cohorts. participants will receive 3 monthly thn391administrations.

Eligibility criteria:
inclusion criteria: * be willing and able to understand the study procedures and the risks involved and provide written informed consent before the first study-related activity * 18 to 80 years of age (inclusive at the time of informed consent). * diagnosis of diabetic macular edema (dme) * vision loss in the study eye exclusion criteria: * be pregnant or breastfeeding * cataract surgery or any other previous ocular surgery in the study eye within 3 months before screening * any other condition except for dme that could affect interpretation of study assessments

Keywords: diabetic macular oedema non-proliferative diabetic retinopathy
effects of diaphragmatic and iliopsoas myofascial release in patients with chronic low back pain

Conditions: Low Back Pain, Recurrent

Summary: the aim of this study is to effectively investigate the relaxation of the diaphragm and iliopsoas muscle with myofascial technique in patients with chronic low back pain.

low back pain is a common health problem that can be seen as a symptom and symptom of many diseases in the clinic. myofascial release technique is thought to be effective in patients with chronic low back pain. therefore, when the literature is examined, it has been observed that the myofascial release technique has studies on pain, range of motion, functionality, muscle stiffness and shortness. this study will be performed on patients with a total of 42 low back pain. the cases will be divided into 2 groups of 21 people by simple random sampling. group 1 (control) will be used with sham diaphragm and iliopsoas muscle myofascial release technique and traditional physiotherapy method. the second group (experiment) will apply the diaphragm and the myofascial release technique of the iliopsoas muscle and the traditional physiotherapy method. patients will be treated for 4 weeks. traditional physiotherapy method will be applied a total of 20 sessions 5 days a week. a total of 12 sessions will be performed, with the myofascial release technique of the diaphragm and iliopsoas muscle applied 3 days a week. the study focuses on the analysis of the following variables: pain : numerical pain scale joint range of motion: goniometer flexibility: tape measure pulmonary function test: spirometer anxiety and depression: beck depression inventory kinesiophobia: tampa kinesiophobia scale disability: roland-morris disability questionnaire the results of these pre-intervention and post-intervention variables will be compared between the two groups .

Eligibility criteria:
inclusion criteria: * patients with chronic low back pain diagnosed by the physician between the ages of 20-50 * both genders * people who have low back pain for 3 months or more * persons who have not received physical therapy application for the past 6 months, who have not used analgesics and non-streoids * volunteer patients exclusion criteria: * having had surgery for the lumbar region or had a surgical diagnosis * spondylolisthesis and inflammatory symptoms in the spine * pregnant patients * other contraindicated conditions determined by the physician: 1. those with systemic infections 2. those with undiagnosed breathing difficulties 3. those with undiagnosed bowel and bladder problems

Keywords: low back pain diaphragm iliopsoas myofascial release
development of eye-tracking based markers for autism in young children

Conditions: Autism Spectrum Disorder

Summary: the main aim of the present study is to examine eye-tracking based markers for social processing deficits in children with autism spectrum disorder (asd). to this end a battery of five eye-tracking paradigms will be administered to young children with asd and typically developing children. to additionally evaluate the specificity of the eye-tracking markers a group of children with disorders of delayed development other than asd will be included.

during an initial screening session all participants will undergo the autism diagnostic observation schedule (ados). asd-related symptomatology and levels of impairments will be further characterized using the social responsibilities scale 2 (srs 2), caregiver strain questionnaire (csq), aberrant behavior checklist (abc), social communication questionnaire (scq), and repetitive behaviour scale revised (rbs-r). subsequently all participants will be administered the following eye-tracking paradigms: (1) dynamic social and non-social visual preference paradigm during which dynamic geometric images (dgi) and dynamic social images (dsi) will be presented, (2) non-biological versus biological motion paradigm, (3) social attention and sharing of enjoyment paradigm, (4) preference for real versus schematic emotional face stimuli paradigm during which photographs of human faces and emoticons will be presented, (5) shared social attention and gaze direction paradigm.

Eligibility criteria:
exclusion criteria for all participants: * visual, auditory or motor impairments * use of medication inclusion criteria for all participants: * written informed consent from parents / caregiver * age: 1-10 years additional inclusion criterion for the asd group: - diagnosis of autism spectrum disorder according to dsm-5 additional inclusion criteria for typically developing children in the control group: * no symptoms of developmental disorders * no current or history of psychological disorder additional inclusion criterion for the unspecific disorder of delayed development children in the additional control group: - disorder of delayed development other than asd

Keywords: eye tracking visual preference
an intervention program to control diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: study to evaluate the effectiveness of a structured intervention to improve diabetes control.


Eligibility criteria:
inclusion criteria: * informed consent * 18-70 adults * type 2 diabetes * males and non-pregnant females exclusion criteria: * use of exogenous insulin for glucose control * use of medications or supplements for weight loss * advanced diabetes complications * recent history of cardiovascular event
gadobutrol/gadavist-enhanced cardiac magnetic resonance imaging (cmri) to detect coronary artery disease (cad)

Conditions: Coronary Artery Disease

Summary: participants being evaluated for suspected or known coronary artery disease (cad) based on signs and/or symptoms, will be invited to participate in the study. the duration for a participant in the study may range from 2 days to 4-6 weeks. one to four visits to the study doctor will be required. this study will investigate the diagnostic results of gadobutrol-enhanced cardiac magnetic resonance imaging (cmri) images regarding the detection (sensitivity) and exclusion (specificity) of coronary artery disease utilizing a uniform image acquisition software. the cmr images will be tested either against the results from routine clinical coronary angiography (ca) or those from computed tomography angiography (cta), which is used as the standard of reference. the ca/cta may have been performed up to 4 weeks prior to enrollment or be scheduled up to 4/6 weeks after the study. cmri and ca/cta images will be collected for an independent image review (blinded read).


Eligibility criteria:
inclusion criteria: * male or female participants aged ≥18 years * participants with suspected or known cad based on signs and/or (typical or atypical) chest pain who have routine ca without intervention or cta within 4 weeks around gadobutrol-enhanced cmri * willingness to undergo stress/rest cmri and to follow directions and complete all study procedures * women of childbearing potential (e.g. age \< 60y, no history of surgical sterilization or hysterectomy): use of contraception and a negative pregnancy test exclusion criteria: * suspected clinical instability or unpredictability of the clinical course during the study period * contraindication to the cardiac mri examination (e.g. inability to hold breath; severe claustrophobia, metallic devices such as pace makers) * history of severe allergic or anaphylactoid reaction to any allergen including drugs and contrast agents according to the investigator's assessment / judgment * estimated glomerular filtration rate (egfr) value \<30 ml/min/1.73 m\^2 derived from a serum / blood creatinine result within 2 weeks prior to gadobutrol injection. any participant on hemodialysis or peritoneal dialysis is excluded from enrollment. * acute renal insufficiency * coronary artery bypass grafting (cabg) * acute myocardial infarction (\< 14 days prior to inclusion), unstable angina / acute coronary syndrome, severe congestive heart failure * irregular heart rhythm * condition that precludes the safe administration of pharmacological stressor according to the respective approved label such as sinus node disease, 2nd or 3rd degree atrioventricular block, obstructive lung disease

Keywords: myocardial perfusion imaging
rsyr for fatigue reduction in cancer survivors

Conditions: Cancer-related Problem/Condition

Summary: this randomized phase ii trial to establish the efficacy of traditional chinese medicine (tcm) herbal products above control group for treating fatigue in patients with cancer.

patients who were randomized and been enrolled in, had stable disease and no anemia, and reported moderate to severe fatigue over two months (rated ≥4 on a 0-10 scale). patients took tcm decoction renshen yangrong decoction (rsyr),which containing 12 tcm herbs, twice a day for 6 weeks. rsyrt aims to correct qi deficiency. fatigue was assessed before and after rsyrt therapy.

Eligibility criteria:
inclusion criteria: pathological diagnosis of malignant tumors; 3 months without surgery, radiotherapy and chemotherapy, biological treatment; hemoglobin \> 11g/l; complete remission of the lesion, or recent review of the disease is stable, the estimated survival time is more than 6 months; ecog score is 0-2, fatigue score of the last 24 hours \> 4 ; age is 18-65 years old; tcm syndrome differentiation for deficiency of qi; liver, kidney function, electrolyte normal; willing to join the group and sign the informed consent. exclusion criteria: allergies to herbs and plant drugs; uncontrollable diabetes, hypertension, tsh abnormalities, uncontrollable pain, and a history of myocardial infarction within 6 months; scores of anxiety disorders and depression (had-d) were 11 or more, antidepressants and antioxidants were used in the past month; breast cancer receptor positive patients took endocrine therapy drugs; tonics were used in the past 2 weeks.; children, pregnant and lactating women; receiving anemia-related treatment; chinese medicine syndrome differentiation with excessive heat; unable to read or understand the scale.

Keywords: fatigue, cancer