Kornimate/medical-research-clean huggingface dataset:
imaging modalities in detection of coronary artery disease in end-stage renal disease patients

Conditions: Coronary Artery Disease; Myocardial Infarction; Stroke; Death

Summary: this study investigates hypothesizes that the combination of dobutamine stress echocardiography with dobutamine stress echocardiography with real time perfusion myocardial contrast echocardiography and coronary computed tomography is a better modality for detecting coronary artery disease in end-stage renal disease patients than coronary angiography, and in predicting patient outcomes. demonstrating this would lead to increased use of dse with rtce and coronary ct at kidney transplant centers throughout the nation, leading to improved anatomical and functional detection of cad without the need for further invasive procedures.

primary: to examine the ability of dobutamine stress dobutamine stress echocardiography with real time perfusion (dse with rtce) and coronary computed tomographic angiography (ccta) to detect anatomically significant coronary artery disease (cad) as defined by quantitative coronary angiography in end-stage renal disease (esrd) patients secondary: to identify which of these tests is most predictive of patient outcomes. this will be a pilot study enrolling 75 participants. this is based off obtaining 80% power and a 90% rectangular confidence region for sensitivity and specificity using one-sided confidence limits, this corresponds to two 95% univariate confidence intervals (one for sensitivity and one for specificity). with 73 patients screened in total there will be 80% power to form a 90% rectangular confidence region around 90% sensitivity and 90% specificity, excluding sensitivities less than 69% and specificities less than 73%. we believe the sensitivities and specificities of both dse with rtce and ccta will be within these confidence regions.

Eligibility criteria:
inclusion criteria: 1. diabetes mellitus 2. patients undergoing kidney transplant evaluation. 3. currently on hemodialysis 4. adults 19-65 years of age 5. written informed consent from a participant who is deemed medically competent by principal investigator, secondary investigators, or participating personnel as written in ii.26 (b) 6. male or female exclusion criteria: 1. previous history of percutaneous coronary intervention 2. coronary artery bypass surgery 3. prior myocardial infarction or ami (troponin greater than 1.0) within 48 hours of the test 4. atrial or ventricular arrhythmias that cannot be controlled to heart rates \<65 beats per minute 5. known allergy to iodinated contrast 6. decompensated congestive heart failure 7. acute respiratory failure as manifested by signs and symptoms of carbon dioxide retention or hypoxemia 8. pregnant (based on history/information obtained from the patient) 9. possibility that potential subject may be pregnant (based on history/information obtained from the patient)
preferred neurostimulation moddalities - prefmod study

Conditions: Chronic Low-back Pain

Summary: this is a prospective 3x3 crossover study with randomized treatment order, comparing the short-term efficacy of conventional-spinal cord stimulation (con-scs) with subcutaneous stimulatio, high frequency-spinal cord stimulation (hf-scs), and combination therapy, in patients with chronic intractable back pain (with or without leg pain).

patients will be preselected for inclusion in this study at the pain management center of neurocenter of southern switzerland, ente ospedaliero cantonale (eoc) lugano, and will be informed about study-details by a study clinician. after informed consent signature, the participants with chronic intractable back or back and leg pain will be implanted with the stimulation lead(s). the leads are initially connected to an external trial neurostimulator. patients will be implanted with two epidural leads and two subcutaneous leads. a three weeks trial phase will follow. the first two days after the leads implant will be without stimulation and thereafter alternating stimulation every week will start, randomly ordering the treatments using a williams design balanced for first-order carryover effects (i.e. incorporating 6 different treatment orders), from: * 1) con-scs with subcutaneous stimulation * 2) hf-scs * 3) combination therapy a patient's favored scs mode, providing that there is at least 50% reduction in pain intensity on the nrs in the trial phase, will then be implanted and patients will be followed up for 12 months. pain intensity and pain medication will be assessed with a pain diary at baseline and during the trial phase and will be furthermore measured after 3, 6, and 12 months after the implantation. physical functioning, pain extent, patient global impression of change (pgic), and satisfaction with stimulation treatment (sst) will be assessed during the trial phase and will be furthermore measured after 3, 6, and 12 months after the implantable nerve stimulator (ins) implantation. the other secondary outcomes will be measured at baseline, and after 3, 6 and 12 months.

Eligibility criteria:
inclusion criteria: * 18 years or older at inclusion * chronic, intractable back or back and leg pain during at least 6 months * pain intensity of ≥ 5 on a nrs (ranging from 0 to 10) * previous drug therapy unsuccessful exclusion criteria: * psychological disorders * coagulation disorders * known immune-deficiency
hereditary haemorrhagic telangiectasia flight safety study

Conditions: Hereditary Haemorrhagic Telangiectasia

Summary: hereditary haemorrhagic telangiectasia (hht) is a condition in which sufferers have abnormal blood vessels which makes them more likely to bleed than other people, particularly in the lungs, which results in low blood oxygen levels. flying may make this worse and cause problems. the investigators want to know if there are an increased number of problems on flights compared to on land. the investigators currently do not have any evidence based guidelines on air travel to best advice people who suffer with hht. the investigators would therefore like to ask individuals who have hht about their experience on a flight, using a postal questionnaire.

individuals with hereditary haemorrhagic telangiectasia (hht) previously reviewed at hhtic london will be sent an invitation to participate in a short questionnaire study. quantitative variables from the questionnaires for statistical analysis will be the number of individuals responding (and number of questionnaires sent out); number of flights taken and number of complications, subgrouped by type, and flight duration in hours. complication rates will be expressed as proportion of person flight hours. the quantitative data from the questionnaire will then be compared with quantitative data from patients' medical records using non parametric methods such as mann whitney for univariate analyses.

Eligibility criteria:
inclusion criteria: hht exclusion criteria: unable to provide informed consent

Keywords: previous flight by aeroplane
identification and validation of blood-based biomarkers for early detection of asymptomatic lung cancer in high-risk heavy smokers

Conditions: Lung Cancers

Summary: the goal of this observational study is to develop and evaluate a blood test for asymptomatic heavy smokers to screen for those at highest risk of developing lung cancer. the aim of this study is to develop, train, and validate a blood-based screening test designed to detect biomarkers associated with lung cancer. the study will utilize samples collected from 4 distinct cohorts. 1. participants confirmed to have lung cancer 2. participants without cancer 3. participants with moderate risk of lung cancer (indeterminate) 4. participants confirmed to have other types of cancers linked to smoking the main question this study aims to answer is whether the blood test can detect existing early-stage lung cancer in heavy smokers without symptoms and to provide insights into device performance and long-term outcomes when scans show no nodules, benign findings, or indeterminate nodules. participants will provide blood samples at the start of the study and during follow-up visits at 12 and 24 months. participants will share information about their smoking history, lung cancer status, and relevant medical history researchers will collect blood samples, process them, and analyze the biomarkers at the everest detection laboratory. no results will be shared with participants or their doctors. the study will run for about 48 months, including a 24-month enrollment period and 24 months of follow-up to track participants' health and lung cancer outcomes.


Eligibility criteria:
inclusion criteria: all participants: * understands the study and can provide written informed consent * willing and able to provide a blood sample * age 30-80 * current or former smoker non-cancer cohort: * recent ct scan within 3 months and * no lung nodules (lung-rads 1) or benign/stable nodules indeterminate cohort: * recent ct scan within 12 months and * indeterminate lung nodules under active monitoring highly suspicious or confirmed lung cancer cohort: * confirmed untreated lung cancer or * highly suspicious lung nodules undergoing diagnostic work-up other cancer cohort: - confirmed, untreated cancer associated with smoking exclusion criteria: * cancer diagnosis within the last 5 years * systemic therapy, radiation, or surgery for cancer within 1 year prior to enrollment * any history of hematologic malignancies or myelodysplasia * known infection with hiv, hcv, or hbv * active pregnancy
cytological screening for early diagnosis of precancerous or cancerous lesions of oral cavity

Conditions: Mouth Neoplasms

Summary: prospective study of diagnosis validation of a cytological technique. 200 patients with oral cavity cancerous and precancerous lesions will be enrolled. a cytological sample of the lesion will be performed by transepithelial brushing ( orcellex® rovers brush) in cytology liquid-based technology (methode thinprep 2000 (hologic®)). a microscopic double blind reading will be performed. a biopsy sampling will be carried out in accordance with current strategy of screening. the brushing diagnosis quality will be compared to the biopsy which is the gold standard.


Eligibility criteria:
inclusion criteria: * one or several cancerous or pre-cancerous lesions of oral cavity newly diagnosed or detected during a follow-up visit exclusion criteria: * pregnant or lactating women * patients under juridical protection

Keywords: oral cavity cancerous and precancerous lesions
enhancing the outcomes of a behavioral parent training intervention

Conditions: Disruptive Behavior Disorder; Parenting

Summary: this study is a feasibility trial, testing the hypothesis that among sedentary mothers of behaviorally at-risk preschool-aged children, those who receive behavioral parent training (bpt) programs and concurrently increase their physical activity levels will demonstrate improved parenting and child behavior outcomes compared to those who receive bpt but remain sedentary.

the investigators will randomly assign 20 participants to two groups: behavioral parent training plus contingency management to increase steps (bpt+cm) or behavioral parent training alone (bpt). contingency management procedures will involve monetary rewards for meeting weekly step-count goals. the specific aims of the proposed project are to: 1) assess the feasibility of the study design and procedures, 2) assess the acceptability of the bpt+cm condition to participants, and 3) determine whether a signal of an effect of increased physical activity exists (via preliminary comparisons of measures of fatigue, perceived energy, parenting behaviors, parenting sense of competence, parenting stress, and child behavior ratings between participants in the two conditions). this innovative pilot study will prepare us for a fully powered trial to test the efficacy of this approach.

Eligibility criteria:
inclusion criteria: * female * age 18 years or older * custodial caregiver of a child aged 2-5 years who lives full-time in the caregiver's home * reports that her child has behavioral problems * never or rarely engages in regular physical activity * able to understand, speak, and read english exclusion criteria: * the child has been diagnosed with a severe developmental condition (e.g., extreme developmental delay, severe autism, debilitating neurological conditions) * participant reports a condition that may contraindicate physical activity (e.g., asthma)
qualitative study on the experiences of mothers 6 to 12 months after their participation in the mother-baby groups of the hugs study

Conditions: Postnatal Depression; Postpartum Depression (PPD)

Summary: the hugs-quali study is a qualitative investigation that explores the experiences of mothers who participated in hugs mother-baby therapy groups. conducted 6 to 12 months after the intervention, the study aims to understand how this culturally adapted therapy influences the bond between mothers and their infants and affects their daily lives. by collecting detailed personal stories through in-depth interviews, the study seeks to understand if the adapted hugs program effectively support french mothers in improving their interactions with their babies, when facing postpartum depression.

postpartum depression affects 15-20% of women in france and is often associated with impaired mother-infant interactions, a disruption observed in up to 73% of cases that can adversely influence both short and long-term child development. although standard treatments effectively reduce depressive symptoms, they frequently fail to enhance the quality of the maternal bond, underscoring the need for interventions specifically targeted at early relational dynamics. the hugs program (happiness, understanding, giving, and sharing), a brief cognitive behavioral therapy originally validated by professor jeannette milgrom's australian team, has been culturally adapted for the french context to improve mother-infant relationships. the ancillary hugs-quali study employs a qualitative approach by conducting in-depth interviews with mothers 6 to 12 months following their participation in hugs mother-baby groups, implemented across several french maternity centers.

Eligibility criteria:
inclusion criteria: * women who participated in the hugs mother-baby groups of the hugs study (at various recruitment sites: toulouse university hospital (paule de viguier maternity), joseph ducuing maternity in toulouse, and bordeaux maternity) and who have completed their follow-up as part of the original study. exclusion criteria: * women refusing to participate in the study. * women who did not participate in the hugs group of the hugs study.

Keywords: postpartum depression mother-child interaction early intervention mother-baby interaction
coordinated healthcare for complex kids

Conditions: Asthma; Diabetes Mellitus; Sickle Cell Disease; Premature Birth

Summary: the university of illinois health and health sciences system (ui health) developed an integrated care management quality improvement model designed to provide comprehensive care coordination for medicaid insured minority children and young adults with chronic health conditions living in chicago. this program, called check (coordinated healthcare for complex kids), targeted children and young adults with chronic disease.

the university of illinois health and health sciences system (ui health) developed an integrated care management quality improvement model designed to provide comprehensive care coordination for medicaid insured minority children and young adults with chronic health conditions living in chicago. this program, called check (coordinated healthcare for complex kids), was funded by a centers for medicare and medicaid services innovation (cmmi) award. the check model took a broad approach to health promotion by addressing social determinants of health, caregiver wellness and mental health needs; in addition to disease management. the program targeted children and young adults from birth to age 25 with diagnoses of asthma, diabetes, sickle cell disease, seizure disorder or prematurity. all participants were enrolled in either the traditional (fee-for-service) state medicaid program or a medicaid managed care organization (mco) in illinois. check provided access to care coordination delivered by community health workers; mental health services and health education. check was designed as a demonstration program and participants were enrolled passively over time and received different services depending on their level of risk and need. one primary aim of the check program was to decrease medicaid expenditures over a three-year period by decreasing unnecessary emergency department visits and hospitalizations. though check was designed as a care delivery demonstration program, in april, 2016 we had the opportunity to prospectively randomize 6,259 participants who met eligibility criteria for check, for the purpose of program evaluation.

Eligibility criteria:
inclusion criteria: * age 0-25 years; * documentation of asthma, * diabetes mellitus (type 1 or 2), sickle cell disease, * seizure disorder or * prematurity; 3) * enrolled in medicaid; and * ride in cook county, illinois. exclusion criteria: • none

Keywords: care coordination children young adults chronic disease
a study to investigate the efficacy and safety of subcutaneous lunsekimig (sar443765) compared with placebo in adult participants with moderate-to-severe atopic dermatitis

Conditions: Dermatitis Atopic

Summary: this is a parallel, phase 2b, randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy, safety, and tolerability of lunsekimig monotherapy in adult participants (aged 18 to 80 years, inclusive) with moderate-to-severe atopic dermatitis (ad). this study explores the efficacy and safety of 3 subcutaneous (sc) dose regimens of lunsekimig in adult participants with moderate-to-severe ad who have a documented history, within 6 months prior to baseline, of an inadequate response to topical treatments or for whom topical therapies are not advised. the study consists of 6 arms: 3 parallel dosing regimens and matching placebo arms. additionally, participants have the option of engaging in a dense pharmacokinetic/pharmodynamic (pk/pd) sampling subgroup. the study duration will be up to approximately 36 weeks, including up to 4 weeks of screening, 24 weeks of treatment period and an 8-week safety follow-up period.


Eligibility criteria:
inclusion criteria: * participants must be 18 to 80 years of age, inclusive, at the time of signing the informed consent. * diagnosis of atopic dermatitis (ad) as defined by the american academy of dermatology (aad) clinical guidelines (2023) for 1 year or longer at baseline (day 1) * documented history within 6 months prior to screening visit, of either inadequate response or inadvisability of topical treatments * eczema area and severity index (easi) score of 16 or higher (range, 0 to 72) at baseline (day 1) * validated investigator global assessment scale for atopic dermatitis (viga-ad) score of 3 or 4 at baseline visit (day 1) (on the 0 to 4 viga-ad scale, a viga-ad score of 3 and 4 represents moderate and severe, respectively). * ad involvement of 10% or more of body surface are (bsa) at baseline (day 1) * weekly average of daily peak pruritis-numerical rating (pp-nrs) score of ≥4 at baseline (day 1) * must have applied a stable dose of topical bland emollient (simple moisturizer, no additives \[eg, urea\]) at least once daily for a minimum of 5 out of 7 consecutive days before baseline (day 1). exclusion criteria: participants are excluded from the study if any of the following criteria apply: * skin comorbidity that would adversely affect the ability to undertake ad assessments (eg, psoriasis, tinea corporis, and lupus erythematosus) according to the investigator's judgment. * known history of, or suspected, significant current immunosuppression note: the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial
social justice advocacy skills and ethical sensitivity

Conditions: Educational Problems

Summary: the aim of this study is to determine the effect of advocacy education on social justice advocacy skills and ethical sensitivity in undergraduate nursing students.

advocacy is an effort to correct or change situations that affect people, society and systems.the origin of advocacy is to provide active support in the latin "advocates" dictionary. it is defined as "defense work" in turkish dictionary advocacy is an ethical dimension of nursing practices in nursing science that shows how nursing care is needed and how the nurse will approach the individual, group and society in need.social justice advocacy has an increasing importance as people are affected by pressure from the social system.disease, weakness and early deaths are more common in ethnic and diverse races, poor people and societies that do not receive services.within the scope of advocacy, the duties and responsibilities of individuals, families and society have been determined by laws and regulations in order to protect and improve the health of the society. advocacy is the nurse's professional role and ethical responsibility.total 80 students (i̇ntervention and control group)was selected randomly from 112 4 th grade student. students were randomly assigned to the experimental group(n=40) and the control group(n=40). the experimental group students will take advocacy intervention courses the control group students will the routine curriculum. in this study, effect size will be determined with 5% error margin by using sample size power analysis gpower 3.1.9.2 program. accordingly, it was calculated that 35 students were included in the intervention and control groups with 5% error margin and 80% power. i̇t was decided to include at least 40 people in each working group with 20% surplus, considering that they might be lost in data collection. theoretical education, film and video screening, case study, social security institution (ssi̇) study, web based work, the student will preparation of advocacy action plan, students prepared poster and advocacy awareness activity, poster were exhibited at the campus. data collection tools: student information form, social justice advocacy scale , moral-ethical sensitivity scale. statistical analysis:similarity of experimental and control groups; number, percentage, average and standard deviation, pre-test, post test; scale scores difference in dependent groups t-test.

Eligibility criteria:
inclusion criteria: * student who speak very well turkish exclusion criteria: * foreign students who do not speak very well turkish.

Keywords: patient advocacy justice social nursing education