Kornimate/medical-research-clean huggingface dataset:
allogeneic hematopoietic stem cell transplantation with reduced intensity pre-transplant conditioning for the treatment of high-risk hematological malignancies (v3)

Conditions: Hematological Malignancies

Summary: this is study is for patients that have been diagnosed with high-risk hematological malignancies. the main purpose of this study is to confirm previously published results of stem cell transplantation with reduced intensity pre-transplant conditioning. patients will be assigned to 1 of 3 regimens depending on the patient's diagnosis. participants will be followed by the transplant team for the remainder of the patient's life. patient's will visit musc daily, then visits will be reduced to frequent visits for up to 6 months. after 6 months, the visits will be reduced more depending on the patient's condition.


Eligibility criteria:
inclusion criteria: * a proven diagnosis of one of the conditions in table 1. * prior therapy including blood or marrow transplant will not exclude patients for reduced intensity transplant. * age \< 75 years. pediatric patients are eligible from the ages of 1 month to 18 years if the transplant physician believes that co-morbid conditions significantly increase the risk for a standard transplant regimen. * hiv antibody negative. * ecog performance status 0-3, (or equivalent karnofsky and lansky performance scores for patients \<18yrs, see appendix 2) * availability of an hla-identical related donor or suitable alternative donor, (≥7/8 allele match at a, b, c and drb). syngeneic transplants will not be allowed in this protocol. * due to the complexity of the study, all patients prior to enrollment will be assessed by the pi or co-pi. * patient with marrow failure states or immune deficiency syndromes undergoing stem cell transplants must be reviewed by one of the investigators to determine eligibility for study. * adequate insurance coverage (or financial resources) to cover the costs associated with the patient's transplant and, in the case of patients eligible for cohort c, to cover the costs associated with i 131 tositumomab treatment. exclusion criteria: * active cns involvement with malignant disease. * pregnancy. * fertile men or women unwilling to use contraceptive techniques during the study period. * creatinine clearance \< 30 ml/min. * left ventricular ejection fraction \<30% or clinical cardiac failure uncontrolled by medical therapy. * pulmonary disease requiring supplemental oxygen therapy. * patients with estimated life span less than 1 year due to medical illnesses other than the condition being treated on the study. donor selection: inclusion criteria * major hla identical relative or genotypically matched unrelated donor (7-8/8 alleles) . * donors must meet the selection criteria as defined by the foundation for the accreditation of cell therapy (fact) and will be screened per the american association of blood banks (aabb) guidelines. exclusion criterion * positive anti-donor hla antibody. * identical twin.

Keywords: high-risk hematological malignancies
graduated compression stockings (gcs) pilot substudy

Conditions: Venous Thromboembolism

Summary: this is a pilot substudy to the perioperative ischemic evaluation-2 trial (poise-2), to assess the feasibility of adding graduated compression stockings (gcs) to poise-2 as an intervention.

objective: to determine if thigh-level graduated compression stockings (below-knee graduated compression stockings may be used if thigh level graduated compression stockings are not feasible, such as after knee surgery), started before surgery and worn until discharge and for a minimum of 10 days (whichever is longer), reduce symptomatic venous thromboembolism (proximal deep vein thrombosis or pulmonary embolism) in the 30 days after surgery.

Eligibility criteria:
inclusion criteria: * randomized to perioperative ischemic evaluation-2 trial (poise-2 trial) exclusion criteria: * unable to wear a graduated compression stockings on a leg that has been operated on (e.g., below knee skin grafting) * leg has not been operated on and graduated compression stockings cannot be worn on either leg (e.g. bilateral leg amputations or skin ulceration, allergy to material in the graduated compression stockings) * graduated compression stockings cannot be fitted because the patient's legs are too big, or too small (not compatible with manufacturer's recommendations) * the responsible physician/nurse judges that graduated compression stockings are contraindicated because of: i) decreased circulation in the legs as evidenced by very pale, cyanotic, or gangrenous conditions; or ii) risk of stocking-induced skin necrosis due to an established sensory neuropathy with numbness to touch.

Keywords: symptomatic venous thromboembolism graduated compression stockings randomized controlled trial noncardiac surgery
under-resourced adults with chronic pain ehealth study

Conditions: Chronic Pain

Summary: the purpose of this study is to examine the feasibility of the dissemination of a cognitive-behavioral ehealth application (app) for pain self-management with black and lgbtq+ adults with high-impact chronic pain lasting at least 3 months and disrupting daily functioning (implementation aim).


Eligibility criteria:
inclusion criteria: * identify as black or lgbtq+. * reside in mn, wi, or ia. * chronic pain diagnosis for at least 3 months. * experience chronic pain that makes it harder to do their day-to-day activities * have daily access to a smart mobile device (smartphone or table) and are willing to use the epio app. exclusion criteria: * unable or unwilling to use the digital app for the study * do not have daily access to a smart mobile device (smartphone or tablet) * self-report cancer related pain, or severe untreated psychological illness (e.g., psychosis); and/or do not fit into one of the demographic categories listed in #1-3 for inclusion criteria.
the effect of progressive relaxation exercise on fatigue in intensive care nurses

Conditions: Intensive Care Nurse; Fatigue

Summary: this study was planned as a randomized controlled experiment. it was aimed to examine the effect of progressive relaxation exercises applied to intensive care nurses on fatigue. the sociodemographic information of the participants will be collected with the 'personal information form' and their fatigue levels with the 'fatigue severity scale'. spss 22.0 package program will be used in the analysis of the data. p\<0.05 will be considered significant.

intensive care nurses experience high levels of fatigue due to the physically and mentally demanding tasks they undertake. for example; conditions such as prolonged seizures, difficulty sleeping, and heavy workload trigger this fatigue. one of the non-pharmacological interventions used in the management of fatigue experienced by intensive care nurses is progressive relaxation exercise (pge). pge involves voluntary, continuous and systematic stretching and subsequent relaxation of various muscle groups and was first described by jacobson in 1938. the purpose of pge is to focus attention on skeletal muscles and relax the whole body. while doing the exercise, the individual feels the difference between tension and relaxation in the muscles. thus, when needed, it learns to relax in order to reduce the tension in the muscles. in the literature, it has been shown that pge reduces the severity of fatigue caused by different chronic diseases. in this context, in this study, it is aimed to examine the effect of progressive relaxation exercise applied to intensive care nurses on fatigue and to contribute to the literature and to the fatigue management of nurses in line with the results obtained.

Eligibility criteria:
inclusion criteria: * working for at least 6 months * having a fatigue severity scale score of 2.8 and above * volunteer to participate in research exclusion criteria: * having a problem that prevents breathing through the nose * having a diagnosis of chronic obstructive pulmonary disease (copd) or asthma * being pregnant * having physical and mental health problems that prevent communication * practicing any complementary method (relaxation exercise, yoga, etc.) during the study * informed about the research but willing to participate in the research

Keywords: fatigue intensive care nursing progressive relaxation exercises
types of photoplethysmographic waves in adult patients with septic shock

Conditions: Shock Septic; Photoplethysmography; Waveform

Summary: the objective of this study is to identify the types of photoplethysmographic waves present in adults with septic shock and determine whether these waves correlate with other variables of tissue hypoperfusion such as capillary refil, serum lactate and mottling score.

photoplethysmography is the technology used in pulse oximeters in order to calculate arterial oxygen saturation and pulse rate, this technology generates a wave whose morphology has been related to blood flow and arterial tone. recently tusman and collaborators described a morphological classification of the photoplethysmografic wave that has a high correlation with arterial tone, such classification is divided in 6 types; types i and ii indicate vasoconstriction, type iii normal arterial tone and types iv, v and vi describe mild, medium and severe vasodilation respectively, therefore it could be used to identify the arterial tone in those patients with septic shock. this study will identify the type of photoplethysmographic waves that are present in adults with septic shock based in the tusman and collaborators classification, it will also describe the frequency of appearance and their correlation with other hemodynamic variables such as capillary refill, serum lactate, mottling score, heart rate, mean arterial pressure, pulse pressure and perfusion index.

Eligibility criteria:
inclusion criteria: * adult patients of 18 years of age and above dignossed with septic shock according to the definition stated in sepsis 3.0 * patients with axillary temperature above 36°c * patients and/or family that agree to participate in such study and sign the informed consentment * patients that tolerate supine position exclusion criteria: * patients with cardiogenic shock, hipovolemic, obstructive and distributive (neurogenic, anafilactic) shock the exception being septic shock * patients with history of any type of cardiac arrhythmia * patients with history of chronic hepatic disease * patients with limited or diffuse systemic sclerosis * patients that have scarring, nail polish or thickened nails that may impede the proper placement and accurate measurement of photoplethysmography with the pulse oximeter * patients with history of heart insufficiency p- atients with septic shock that already have vasopressor aggents

Keywords: shock septic waveform vasodilation photoplethysmography arterial tone
cleidocranial dysplasia (ccd): from genotype to phenotype and considerations for care

Conditions: Cleidocranial Dysostosis

Summary: cleidocranial dysplasia (ccd) is a rare, autosomal dominant disorder characterized by dysplasia of bones and teeth. given the rarity of this condition (prevalence of 1 in 1,000,000), the variable phenotype and lack of correlation to specific genotypes, coordinated clinical research is needed to better understand ccd. the purpose of this project is to: investigate the genetic makeup and phenotypic expression of ccd, understand the quality of life for patients with this diagnosis, and further identify the multidimensional healthcare needs of these patients. participation involves completion of a survey to ascertain medical history and quality of life, a physical exam and research whole exome sequencing from a blood or saliva sample. the goal of this research is to elucidate critical pathways in skeletal and dental development and improve quality of life for ccd patients through the standardization and optimization of timely diagnosis and multidisciplinary care.


Eligibility criteria:
inclusion criteria: * patient has molecular or clinical diagnosis of ccd * caregiver or parent of patient with ccd. exclusion criteria: * patient does not have ccd * patient over 18 but cannot consent for themselves * not fluent in english.
phase ii pilot study of visudyne® photodynamic therapy (pdt) (low and very low fluence) combined with bevacizumab.

Conditions: Macular Degeneration

Summary: to determine if visudyne photodynamic therapy (low or very low fluence rate) combined with intravitreal injections of bevacizumab (avastin) compared with bevacizumab alone will, with similar safety and efficacy, delay time to retreatment with bevacizumab after the initial treatment, in subjects with new wet amd hypothesis: pdt in combination with avastin at either the low or very low fluence rate will delay time to retreatment and reduce the average number of treatments required, compared to avastin alone, but will have a similar safety and efficacy profile.


Eligibility criteria:
inclusion criteria: new wet amd exclusion criteria: -

Keywords: amd avastin visudyne medical condition being studied amd
evaluation the safety and tolerance of gp681 tablets in healthy subjects

Conditions: Influenza

Summary: influenza (influenza for short) is an acute respiratory infectious disease caused by influenza virus. the symptoms of the disease range from mild, moderate to severe, and severe cases require hospitalization and may die. according to estimates by the us centers for disease control and prevention in 2018, influenza causes approximately 290,000 to 640,000 deaths worldwide each year. therefore, the prevention and treatment of influenza has become a serious public health problem.

the gp681 in this test is a prodrug of a polymerase acidic protein (pa, polymerase acidic protein) inhibitor. its metabolite gp1707d07 can selectively inhibit the cap-dependent endonuclease of influenza virus and prevent influenza virus replication. mechanism of action against influenza virus. the results of previous non-clinical studies show that gp681 can effectively inhibit influenza virus replication, has good safety, and has antiviral activity 1,000 times that of oseltamivir phosphate. it also has good antiviral activity against oseltamivir resistant strains. and it is expected to have a longer half-life than oseltamivir phosphate. therefore, it is expected that a new type of pa inhibitor can be developed to provide patients with influenza with a new mechanism of action, better efficacy, and higher compliance.

Eligibility criteria:
inclusion criteria: - 18-45 years old, male or female (the food impact test is limited to males); male ≥50 kg, female ≥45kg,bmi19-26; fully understand the purpose and requirements of this trial, voluntarily participate in the clinical trial and sign a written informed consent form, and be able to complete the entire trial process according to the trial requirements. exclusion criteria: - history of allergies, allergic diseases or allergies to drugs in research; medical history of the central nervous system, cardiovascular system, digestive system, respiratory system, urinary system, blood system, metabolic disorders, etc. or other diseases that are not suitable for participating in clinical trials (such as mental illness history, etc.); donated blood or blood loss ≥ 400 ml within 3 months before enrollment;
open-label trial of oral pf-00299804 by continuous dosing in patients with recurrent or metastatic head and neck squamous cell cancer

Conditions: Head and Neck Neoplasms

Summary: this study will investigate the safety and efficacy of oral pf-00299804 in patients who have not yet undergone any other drug treatment for recurrent and/ or metastatic head and neck squamous cell cancer.


Eligibility criteria:
inclusion criteria: * recurrent or metastatic squamous cell cancer of the head and neck; * measurable disease; * eastern cooperative oncology group (ecog) 0-1 in stage 1 = first 23 patients; * eastern cooperative oncology group (ecog) 0-2 in stage 2 = 33 patients; exclusion criteria: * prior therapy for recurrence; * platelets \< 75,000; * prior epidermal growth factor receptor (egfr) therapy; * interstitial lung disease; * primary of nasopharynx

Keywords: recurrent or metastatic squamous cell cancer of the head and neck; no prior systemic therapy for recurrence
multicenter survey about acute uncomplicated diverticulitis management

Conditions: Acute Uncomplicated Diverticulitis

Summary: acute uncomplicated diverticulitis is a quite prevalent situation and consultation in the emergency department. its management has progresively changed towards a more conservative one and it is currently recommended in several guidelines the option of avoiding antibiotics in certain highly selected cases. nevertheless, the implantation of such recommendations in current clinical pratice is unknown and, hypothesizing it was still low, the reasons for such reluctancy are also unknown. both aspects can be considered quite interesting in order to design a specific plan in order to overcome such difficulties. in order to do so, an online survery was designed and colorectal surgeons along spain, based in the census of the young group from the spanish association of colorectal surgery were invited to participate. invitations were distributed along usual communication channels of this group, such as email or chat mobile phone applications. all the responses to the survey will be analyzed in order to find out how many hospitals are using current managemente without antibiotics, its characteristics and, opposite, what are the main reasons for those hospitals that are not using it yet.


Eligibility criteria:
inclusion criteria: * colorectal surgeons. * surgeons with emergency surgery activity. exclusion criteria: * any other medical speciality.
high tibial osteotomy with/without fulkerson osteotomy in knee oa

Conditions: Osteoarthritis, Knee; Patellofemoral Disorder

Summary: this study will compare hight tibial osteotomy with or without fulkerson osteotomy performed on patients with early stages of osteoarthritis with patellofemoral joint disorders. the purpose of this study is evaluate which type of osteotomy provides better clinical, radiological and laboratory outcomes.

progression of knee cartilage degenerative changes leads to necessary total knee arthroplasty in future, which is the most popular procedure for treating oa. hto applied at early stages of osteoarthritis allow slow down cartilage degeneration process, but the choice of performed surgery depends on surgeons personal assessment. patellofemoral pain syndrome often occurs with knee arthritis. antero-medialisation of tibial tubercle is frequent procedures for patella maltracking. so far, both, hto and fulkerson osteotomy was performed separately, even if patient have symptoms from patellofemoral joint and oa. the investigators believe that simultaneously surgery of hto and fulkerson osteotomy provides better outcomes and significantly slow down knee degeneration.

Eligibility criteria:
inclusion criteria: * knee medial compartment or patellofemoral osteoarthritis in medical interview and physical examination * confirmation of cartilage degeneration/damage and knee malalignment in radiological tests exclusion criteria: * no informed consent to participate in the study * age under 18 years or above 65 * multi ligament injury or single plane knee instability * another musculoskeletal disorders in lower limb * lower limb deformity requiring axis correction below 4o or above 12.5o * joints inflammatory diseases * asa score \> ii

Keywords: hto fulkerson osteoarthritis
optimizing peep in laparoscopic bariatric surgery using bedside lung ultrasound

Conditions: Atelectasis, Postoperative Pulmonary

Summary: lung ultrasound imaging is a promising non-invasive, non-radiant, portable and easy to use tool that as yet to be studied in the intraoperative setting. in our current study, we are trying to reach the optimum peep in laparoscopic bariatric patients to prevent postoperative collapse and atlectasis with simple non-invasive procedure.


Eligibility criteria:
inclusion criteria: * they are between 18 and 65 years of age * bmi more than 35 * patients with normal respiratory functions * asa 1 or 2 exclusion criteria: * previous lung surgery * bronchial asthma * contralateral lung bullae 4. uncompensated cardiac disease (nyha class 3 or 4) 5. obstructive or restrictive lung disease 6. patients on home oxygen therapy 7. hemodynamic instability and increased intracranial pressure 8. in adittion , any patient who developes hemodynamic instability (map \<60mmhg) or hypoxia (po2 less than 60) during the study will excluded from the study
functional mri of cognitive control in autism

Conditions: Autism

Summary: this study aims to investigate the role of fronto-striatal circuits and cognitive control in the perseverative and inflexible behavior that is a defining feature of autism. we hypothesize that deficits in the development of fronto-striatal circuitry may underlie cognitive inflexibility in autism. specifically, we hypothesize that repetitive, inflexible behavior arises as (1) fronto-striatal systems are capable of learning patterns present in the environment (as in implicit learning paradigms), but are unable to adapt behavior to changing circumstances, related to either (2) decreased ability of basal ganglia to detect violations of expectancy, (3) decreased ability of prefrontal cortex to respond to detected violations, or (4) decreased connectivity of the circuits. we are conducting three functional magnetic resonance imaging (fmri) studies to address these hypotheses.


Eligibility criteria:
inclusion criteria: * aged 6 - 12 years at inclusion inclusion criteria for subjects with autism * dsm-iv (apa, 1994) diagnosis of autism, according to adi-r interview inclusion criteria for controls * no dsm-iv (apa, 1994) diagnosis, according to disc interview * no scores in the clinical range on the child behavior checklist (cbcl) and teacher rating form (trf) * iq \> 70 exclusion criteria: * major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system * presence of metal objects in or around the body (pacemaker, dental braces) * history of or present neurological disorder

Keywords: functional mri
magnetic nanoparticle sperm separation for teratozoospermia male and women older than 35 years

Conditions: Infertility

Summary: women over 35 years old are likely to suffer from impaired oocyte repair capacity. teratozoospermia is a condition reflects morphological affection of sperm. these spermatozoa would add an extra burden on the oocyte after icsi. whether selecting mature sperm by magnetic nanoparticle protocol would provide a more competent sperm to a likely affected oocyte would improve icsi outcomes is the question of this research.


Eligibility criteria:
inclusion criteria: * women indicated for icsi but with teratozoospermia exclusion criteria: * women not failing in this group