Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of heparin-coated surface-treated polyacrylonitrile membrane hemofilter in critical ill crrt patients

Conditions: Critical Ill Patients; Patients Needing Continuous Renal Replacement Therapy

Summary: crrt patients are generally critical ill patients with unstable conditions, such as low blood pressure,severe sirs,et al. acute kidney injury(aki)is especially prevalent,with even two or more organ failure. crrt serves as an important supportive therapy.continuous anticoagulation is needed to prevent treatment interruptions due to clotting of the extracorporeal circuit. unfractionated heparin or low molecular weight heparin both increase the risk of bleeding and heparin induced thrombocytopenia in such cases.however, the problem of crrt without anticoagulation is the early filter clotting. an alternative method is the use of heparin coated hemofilter. the an69 st hemofilter, a surface-treated polyacrylonitrile membrane hemofilter, allows irreversible fixing of heparin to filter membrane, is able to reduce thrombogenic properties of the membrane. in this study, we observe the efficacy and safety of heparin-coated an69 st hemofilter in crrt patients, and compare to the original an69 membrane hemofilter.


Eligibility criteria:
inclusion criteria: * critical ill patients who need continuous renal replacement therapy * continuous anticoagulation therapy is not necessarily during crrt process exclusion criteria: * patients needing continuous anticoagulation during each crrt process * expectant survival time less than 72 hours * extremely unstable vital signs such as low blood pressure * any reasons that resulting in blood flow rate less than 150ml/min * pregnant women * patients allergic to heparin

Keywords: heparin-coated surface-treated polyacrylonitrile membrane hemofilter critical ill acute kidney injury chronic kidney disease continuous renal replacement therapy
steady state bioequivalence study of torrent pharmaceuticals ltd's bioequivalence study of torrent pharmaceuticals ltd's quetiapine tablets

Conditions: Schizophrenia

Summary: objective: primary objective was to study steady-state bioequivalence of torrent's quetiapine fumarate tablets 300 mg. study design: randomized, two-way, crossover, multiple dose, and open-label


Eligibility criteria:
inclusion criteria: * sex: male of female * age: 25-65 years * patients who are receiving a stable daily dose of quetiapine 300 mg every 12 hourly for atlist one month * patient willing to adhere to the protocol requirements exclusion criteria: * clinically relevant abnormalities in the results of the laboratory screening evaluation. * clinically significant abnormal ecg. * significant orthostatic hypotension (i.e., a drop in systolic blood pressure of 30 mm hg or more and/or a drop in diastolic blood pressure of 20 mm hg or more on standing) * concurrent use of antihypertensive medication or any medication that might pre-dispose to orthostatic hypotension. * history of allergic reactions to quetiapine or other chemically related psychotropic drugs. * concurrent primary psychiatric or neurological diagnosis including organic mental disorder, severe tardive dyskinesia, or idiopathic parkinson's disease. * existence of any surgical or medical condition, which in the judgement of the principal investigator, might interfere with the absorption, distribution, metabolism or excretion of the drug or likely to compromise the safety of patients. * concurrent use of other drugs known to suppress bone marrow function. * hiv, hcv, hbsag positive. * expected changes in concomitant medications during the period of study. * a history of epilepsy or risk for seizures * positive urine drug of abuse test at enrollment. * a history of alcohol or drug dependence by diagnostic and statistical manual of mental disorders iv(dsm-iv) criteria during the 6 month period immediately prior to study entry. * a total white blood cell count below 4000/ml, or absolute neutrophil count below 2000/ml * female patients with pregnancy or breast feeding or intend to become pregnant during the study and not able to follow contraception methods. * history of multiple syncopal episodes. * administration any study drugs in last 3 months prior to entry in the study. * history of significant blood loss due to any reason in the past 3 months. * any pre-existing bleeding disorder.
effect of linezolid on ex vivo neutrophil and monocyte function in healthy males

Conditions: Gram Positive Infection

Summary: results from previous studies have been inconclusive and the effect of linezolid on cytokines remains unclear. this study is designed to evaluate the effect of linezolid on the functionality of white blood cells (neutrophils and monocytes) in healthy subjects.


Eligibility criteria:
inclusion criteria: * healthy male subjects between the ages of 20 and 45 years, inclusive (healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and pulse rate measurement and clinical laboratory tests). * body mass index (bmi) of 17.5 to 30.5 kg/m2; and a total body weight \>50 kg (110 lbs). exclusion criteria: * any condition possibly affecting drug absorption (eg, gastrectomy). * subject who had a bacterial/viral infection within 2 weeks prior to the first dose of study medication. * subjects with current or prior neutropenia (eg, \<1.4 x 109 neutrophils /l).
esp block in radical prostatectomy

Conditions: Erector Spinae Plane Block

Summary: our study aimed to examine the effects of ultrasound guided erector spinae plane block in radical prostatectomy surgery on pain and surgical stress response, to reduce adrenocortical and sympathetic discharge due to anesthesia and surgery, and to reduce peroperative opioid analgesic consumption.

in this study 46 patients between the ages of 30-74, american society of anesthesiologists (asa) score i-ii and undergoing radical prostatectomy surgery at t.r. ministry of health i̇stanbul göztepe prof. dr. süleyman yalçın city hospital were included. the patients were randomly divided into two groups as espb applied group b (n=23) and not group k (n=23). patient-controlled analgesia (pca) was initiated in all patients for postoperative analgesia. patients' demographic data (age, gender, asa score), intraoperative hemodynamic data, intraoperative and postoperative additional narcotic consumption, postoperative numeric rating scale (nrs) scores (postoperative 0, 5 and 20 minutes and then, 1, 3, 6, 12, 18 and 24 h), postoperative nausea-vomiting scores and possible complications related to block and / or surgery were recorded.intraoperative map, hr, spo2, bis values of patients in both groups were recorded every 5 minutes. blood glucose, insulin, cortisol, prolactin and c-reactive protein (crp) were studied three times; preop morning at 6:00, intraoperative when surgical incision closing and postoperative 24h. in order to evaluate the surgical stress response in the patients.

Eligibility criteria:
inclusion criteria: * asa i-ii exclusion criteria: * diabetes * coagulopathy * local anesthetic * drug allergy * long hospitalization history, * hormone disorder * advanced organ failure * history of steroid use * vertebral anomalies * mental retardation

Keywords: erektor spinae plane block postoperative analgesia surgical stress response
povidone-iodine for nasal decolonization

Conditions: Surgical Wound Infection; Preoperative Care; Methicillin-Resistant Staphylococcus Aureus

Summary: to evaluate the efficacy and tolerability of 10% povidone-iodine in eliminating nasal carriage of staphylococcus aureus and mrsa. to determine whether a more convenient, single-dose, pre-operative 10% povidone-iodine (pi) application is effective in reducing nasal carriage of s. aureus and mrsa. we expect a statistically significant decrease in s. aureus/mrsa colonization in nasal cultures taken perioperatively after intervention in patients who received pretreatment with pi as compared to patients who received normal saline (ns).

this will be a prospective single-blinded randomized placebo-controlled trial of two applications of a nasal 10% povidone iodine (pi) solution used on the intranasal mucosal surfaces of each nostril in the preoperative holding area within 2 h prior to surgical incision compared with ns using the same technique. both the pi and ns will be applied by rotating the swab over the intranasal mucosal surface for 15 seconds; this process will be performed twice for both nostrils, using a new swab for each application. nasal cultures will be obtained prior to pi or ns application as well as intraoperatively 1 hour and 2 hours after first surgical incision. the primary study end point is the decrease in s. aureus/mrsa colony forming units (cfu) in nasal cultures taken within 2 hours after intervention in patients who presented with a positive preintervention nasal culture. a secondary endpoint is the presence or absence of surgical site infections within 30 days postoperatively

Eligibility criteria:
inclusion criteria: * community-based patients ages 18-80 * american society of anesthesiology (asa) 1-3 * undergoing an outpatient surgery for at least 1 hour and up to 6 hours duration exclusion criteria: * pregnancy * allergy to povidone-iodine * infectious indication for surgery or preexisting known infection/wound * immunocompromised state * use of chemotherapy or steroids within 30 days prior to surgery * use of antimicrobial therapy within 30 days prior to surgery * surgeries where field avoidance prevents intraoperative access to the nares
intravenous tranexamic acid in diabetic macular trd surgeries

Conditions: Diabetic Retinopathy; Macular Traction Retinal Detachment

Summary: the goal of this observational study is to learn about safety and results of peroperative and intraoperative intravenous tranexamic acid for diabetic macular tractional detachment eye surgeries . the main question it aims to answer is: adverse events and their frequency? immediate postoperative bleeding incidence? effective vitrectomy time?

all patients who agreed and gave informed consent forsurgery as well as to be included in study were included patients injected intravenous tranexamic acid 500 mg diluted to 10 ml with normal saline slowly in immediate preoperative period accordingly, whenever bleeding was anticipated before removing active taut membranes or when bleeder was noted txa 0.5 g was added upto maximum of 2 g. in chronic kidney disease patients dose was kept as maximum of 1.5 g data analysis pack of microsoft excel will be used for statistical analysis. descriptive statistics will be applied. wherever mean of continuous variables is to be compared among subgroups, unpaired students t test will be used. to find any relationship among continuous variables , pearsons correlation or multiple regression will be used from data analysis pack of microsoft excel.

Eligibility criteria:
inclusion criteria: * eyes of diabetic patients having macular tractional retinal detachment confirmed on indirect ophthalmoscope or b scan when associated with vitreous hemorrhage or optical coherence tomography exclusion criteria: * pregnancy, lactation, oral contraceptive use, within 6 months thromboembolic disease ,underlying cardiac arrhythmia where anticoagulation is indicated ,seizures severe liver disease,previous history of variceal bleeding ,allergic history to tranexamic acid ophthalmic exclusion criteria previous vitreoretinal surgery combination of tractional and rhegmatogenous retinal detachment coexisting macular hole macular dystrophies arterial or venous occlusions age related macular degeneration extensive macular scarring posterior segment inflammation

Keywords: tranexamic acid diabetes mellitus macular trd
effect of esketamine on abdominal pain during tace-haic in patients with hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma; Transarterial Chemoembolization; Hepatic Arterial Infusion Chemotherapy; Pain

Summary: previous studies have confirmed that limb pain caused by oxaliplatin chemotherapy is related to spinal cord central sensitization - induced hyperalgesia through oxaliplatin activating spinal cord nmda receptor(n-methyl-d-aspartic acid receptor). the investigators speculate that this may be the same as the mechanism of severe abdominal pain caused by haic(hepatic artery infusion chemotherapy) during oxaliplatin infusion. the analgesic effect of esketamine is mainly related to its inhibition of nmda receptor in spinal cord. therefore, this study hypothesized that esketamine can inhibit the sensitization of spinal cord center by inhibiting nmda receptor, so as to alleviate severe abdominal pain during haic perfusion, and reduce abdominal pain caused by ischemia and inflammation by tace(transcatheter arterial chemoembolization) by improving organ perfusion and anti-inflammatory effect, therefore, it is expected that esketamine can better alleviate acute severe abdominal pain caused by tace-haic (transcatheter arterial chemoembolization combined with hepatic artery infusion chemotherapy )treatment than sufentanil, decrease the dosage of opioids, and reduce the incidence and degree of chronic abdominal pain after treatment.


Eligibility criteria:
inclusion criteria: * participate in this study and sign informed consent * voluntarily receive postoperative intravenous controlled analgesia * patients receiving tace-haic treatment * hcc (hepatocellular carcinoma)patients with primary liver cancer bclc(barcelona clinic liver cancer) stage b and c, liver function a * age 18 to 80 exclusion criteria: * patients who were unable to cooperate or refused to participate in the trial * pregnant women * patients with sensory abnormalities such as diabetes neuropathy * patients with or having a history of serious mental disorders * patients with poorly controlled or untreated hypertension (arterial hypertension, resting systolic / diastolic blood pressure more than 180/100mg) * patients with unstable angina pectoris or myocardial infarction within 6 months or congestive heart failure * patients with intracranial hypertension or glaucoma * patients with hyperthyroidism without treatment or insufficient treatment * patients with severe respiratory dysfunction * allergy or existing contraindication to chemotherapeutic drugs, opioids or ketamine drugs * can not follow with the study procedure
total intravenous anaesthesia (tiva) versus spinal anaesthesia in patients undergoing transurethral prostate resection

Conditions: Prostate; Hyperplasia

Summary: comparison of total intravenous anaesthesia with spinal anaesthesia in patients undergoing transurethral prostate resection

comparison of total intravenous anaesthesia with spinal anaesthesia in patients undergoing transurethral prostate resection regarding patient satisfaction and discharge time

Eligibility criteria:
inclusion criteria: * 18 years and older * signed informed consent * elective transurethral prostata resection exclusion criteria: * asa more than 3 * kidney disease, liver disease * intolerance against bupivacaine, fentanyl, propofol og remifentanil * chronic pulmonary disease * dementia

Keywords: prostata hyperplasia transurethral resection tiva spinal anaesthesia
video gaming improves robotic surgery simulator success

Conditions: Robotic Surgery; Simulator

Summary: investigators aimed to investigate the effects of video game habits, duration of experience, and training in different surgical clinics on the success of robotic surgery simulators. in this prospective, observational, comparative, and multi-clinic study, all participants played the temple run and piano tiles 2™ mobile games for one month after responding to a questionnaire including their sociodemographic characteristics, surgical experience, and past and current video game experience. at the end of the study period, participants experienced four different robotic surgery simulator tasks (camera targeting 1, energy switching 1, ring \& rail 2, vertical defect suturing) in the da vinci® skills simulator™. additionally, sociodemographic data were statistically analyzed with mobile game scores, and 13 different performance scores were obtained from the simulator.


Eligibility criteria:
inclusion criteria: * to be a physician trained in surgery in the department of general surgery. pediatric surgery and urology. * to be an assistant and specialist of the departments with robotic surgery experience. * to be acquainted with laparoscopic surgery. * having played video games. exclusion criteria: * participation in our study is on a voluntary basis and we have no criteria other than physicians who want to leave the study voluntarily.

Keywords: robotic surgery simulation-based learning video game experience surgical education
genetic contribution of pain and inflammation in ibs

Conditions: Irritable Bowel Syndrome

Summary: the goal of the study is to identify possible polymorphisms on the loci of candidate genes that may be involved in modulation of pain and inflammation in irritable bowel syndrome.

stored and de-linked blood or dna from subjects with ibs will be utilized for analysis for possible polymorphisms at predetermined genetic loci located in chosen genes.

Eligibility criteria:
inclusion criteria: * subjects with ibs and previously stored samples exclusion criteria: * subjects without ibs and no previously stored samples

Keywords: ibs
study of inflammatory markers and symptom severity in personalized nutritional intervention in ibs

Conditions: IBS - Irritable Bowel Syndrome; Inflammation

Summary: irritable bowel syndrome (ibs) is a widespread disease with variable symptoms that have an important impact on the quality of life. despite the prevalence of ibs, its etiology and pathophysiology are still to be fully understood, but immune response is known to be involved. in this study, the investigators researched the variation of two specific cytokines, b-cell activating factor (baff) and platelet-activating factor (paf), the levels of food-specific igg and the symptom severity, using irritable bowel syndrome - symptom severity score (ibs-sss), following a personalized an unrestricted-calorie diet.

the investigators enrolled 30 subjects with diagnosis of ibs, according to rome-iv criteria, whose inflammatory markers were measured at baseline and after 6 weeks of dietary intervention. the subjects were monitored in a general practice outpatient setting (gp) and nutritional advice was offered remotely via two telephone sessions with a nutritionist. the researchers investigated the variation of two specific cytokines, b-cell activating factor (baff) and platelet-activating factor (paf), the levels of food-specific igg and the symptom severity, using irritable bowel syndrome - symptom severity score (ibs-sss). data monitoring was ensured by an external monitor (hippocrates research, genova, italy). all data entry was in accordance with gcp protocol, and ae were classified using ctcae 4.0

Eligibility criteria:
inclusion criteria: * ibs (according to rome iv criteria) * blood analysis within 1yr with cbc, tshr, esr, crp, urine, glucose * attitude to change dietary habits * willing to follow study protocol exclusion criteria: * low bmi (\<18.5 kg/m2) * pregnancy * restrictive dietary habits (e.g. veganism) * positive fobt * faecal calprotectin \>200 mcg/g * known or recurrent bowel infections * known or recurrent uti (\>3/yr) * former diverticulitis * alcohol abuse * major concurrent disease (e.g. ibd, coeliac disease, eating disorder,...) * pharmacological treatment with drugs that alter intestinal motility (e.g. ppi, metformin,...)
targeted intraoperative therapy registry at bethesda north hospital (targit)

Conditions: Early Stage Breast Cancer; Neoplasm of the Breast; Breast Tumor

Summary: the purpose of this study is to create a registry to evaluate the use of intra-operative radiation therapy (iort) and to study the efficacy and toxicity of breast radiotherapy given intra-operatively as a single fraction after breast conserving surgery,

a registry trial has been designed and modeled after the original successful targit protocol, to continue the use of iort for a select population of women, and to follow outcomes with regards to local and regional control, toxicity and morbidity. patients selected for breast conserving surgery, who are considered to have a low risk of local recurrence, are eligible for this registry trial once their informed consent is obtained. this single arm cohort study allows entry of patients who have been diagnosed with early stage breast cancer and whose clinical stage is suitable for treating conservatively (small tumor and no gross nodal involvement). tumors should not be more than 3.5 cm in size.

Eligibility criteria:
inclusion criteria: * female * age 45 or greater * diagnosed with operable invasive breast cancer, t1 and t2 (\< 3.5 cm), n0, m0, confirmed by cytological or histological examination * suited for breast conserving surgery * have had an ipsilateral (same side as current cancer) diagnostic mammogram within 12 months of enrollment exclusion criteria: * age 44 or less * axillary lymph node positive breast cancer * invasive lobular cancer * tumor size \> 3.5 cm * extensive intraductal component (eic= \> 25% of the lumpectomy specimen involved with ductal carcinoma in situ, dcis) as assessed on surgical pathologic lumpectomy specimen * multicentric cancer in the same breast not amenable to excision with a single lumpectomy * inability to assess pathologic margin status * synchronous bilateral breast cancer at the time of diagnosis. * ipsilateral breast had a previous cancer and/or prior in-field radiation. * patients known to have brca1/2 gene mutations * neoadjuvant treatment (hormones or chemotherapy)
gaming console home-based exercise for adults with cystic fibrosis

Conditions: Cystic Fibrosis

Summary: physical activity and exercise have become an accepted and valued component of cystic fibrosis care. regular physical activity and exercise can slow the rate of decline of pulmonary function, improve physical fitness, and enhance quality of life. however, motivating people to be more active is challenging. supervised, facility-based exercise programs are expensive and labor intensive (since groups of patients with cf cannot exercise together in the same physical location). home-based exercise using an interactive exergame device may be an effective way to improve adherence to an exercise program for patients with cf. therefore, the primary objective of this study is to evaluate the effects of a 12-week, home-based exergame exercise intervention on aerobic capacity (peak vo2). the secondary endpoint is nasal potential difference, an indicator of how well sodium and chloride flow across the mucous membranes in the nose. other outcomes include patient-reported quality of life and habitual physical activity level. following baseline assessments participants will be begin a 12 week, partially-supervised exercise program consisting of at least 90 minutes per week of aerobic and resistance exercise training using the nintendo wii fit plus exergaming device. participants will receive at least monthly follow-up phone calls to provide additional exercise counseling and motivation. after 12 weeks, they will continue with the exergame intervention for another 12 weeks, but without external supervision.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of cf * currently sedentary (\<60 min/week of physical activity) * stable clinical condition (no exacerbation in last 6 weeks) exclusion criteria: * nasal surgery for polyposis in the past 2 years * participating or have participated (in the past 30 days) in another clinical trial which can affect the outcomes of the proposed study * unable to read/speak english * recurrent pneumothorax (in the past 6 months) * hemoptysis (hospitalized in the past 6 months) * uncontrolled cf-related diabetes (hba1c \> 10%)

Keywords: exercise