Kornimate/medical-research-clean huggingface dataset:
in vivo anatomy, physiology, mechanics and function of the lower esophageal sphincter

Conditions: GERD; Barretts Esophagus

Summary: the purpose of this study is: * to study the components of the gastroesophageal junction high-pressure zone individually and as a group, by pharmacologically eliminating or accentuating the pressure profile generated by the smooth muscle components. * to differentiate the gastric sling fibers from the clasp fibers based on the spatial orientation of these muscle groups.

the purpose of this research study is to examine and evaluate a part of the digestive system (gastrointestinal tract). the specific part the study team will look at is called the "lower esophageal sphincter complex." this complex is located where the esophagus (food pipe) meets the top of the stomach. the lower esophageal sphincter complex involves a group of muscles, and the study team hopes to better understand how they work. the study team hopes that, by studying the lower esophageal sphincter complex, it may be possible to discover how it functions and what causes it to fail. when a complex fails, this can lead to reflux and heartburn. so learning more about the lower esophageal complex may help doctors' better treat future patients with reflux problems. we plan to study these functions in normal control subjects, in patients with gerd (heartburn symptoms), and in patients with barrett's esophagus (a change in the lining of the esophagus due to chronic reflux). the doctor performing the study procedure has previous experience with and is skilled in performing these procedures.

Eligibility criteria:
inclusion criteria: inclusion criteria for gerd patients are: * symptomatic heartburn * regurgitation * chest pain or water brash exclusion criteria: exclusion criteria for normal volunteers include: * medications-subjects on any medication which could effect the gastroesophageal junction high-pressure zone will be excluded, this includes use of antacids, h2 blockers, proton pump inhibitors, prokinetic agents, erythromycin type antibiotics and anticholinergics. * gi symptoms, conditions and disorders in addition exclusion criteria will include a history of: * esophagitis * gastrointestinal symptoms such as abdominal pain * heartburn * reflux * regurgitation * chest pain * difficulty swallowing * pain on swallowing * dysphagia * abdominal surgery involving the stomach or esophagus * nausea or vomiting * diabetes * scleroderma * esophageal motility disorders * non cardiac chest pain * achalasia and current pregnancy.

Keywords: gerd heartburn esophageal reflux barretts esophagus normal subjects
temporary clipping of the uterine arteries during laparoscopic myomectomy

Conditions: Leiomyoma; Laparoscopic Myomectomy

Summary: the aim is to verify, whether intraoperative temporary clipping of the uterine vessels with vascular clips can reduce blood loss significantly.


Eligibility criteria:
inclusion criteria: * patients are eligible for the study when between 18 and 50 years of age, * diagnosed with either symptomatic or asymptomatic leiomyomata, and with desire to keep the uterus, and whose leiomyomata had a minimal combined diameter of ≥ 4 cm. exclusion criteria: * patients with severe accompanying medical problems, or * with psychiatric illnesses, which jeopardize the participation, or * undergoing treatment affecting coagulation and/or hematopoiesis, and * patients with suspected malignancy.

Keywords: laparoscopic myomectomy, leiomyoma, blood loss, uterine artery
diet & activity community trial: high-risk inflammation

Conditions: Inflammation

Summary: south carolina has many gaps in health status of our citizens. some of the biggest gaps are higher cancer rates among african americans. the purpose of this study is to find people who have increased inflammation and study how well a community-based dietary and physical activity program works at reducing the risk of african americans developing inflammation-related diseases.

a diet and physical activity intervention was developed to provide knowledge and skills to facilitate health behavior change in african-american baptist church members in south carolina and promote healthy lifestyles to reduce colon cancer disparities. the intervention entitled, "h.e.a.l.s. (healthy eating and active living in the spirit)" was used to train church education teams to deliver church and community educational activities promoting a diet rich in fruits and vegetables and an active lifestyle. the training focused leadership and empowerment skills to enable church lay leaders to become church education teams (cets) . the educational activities made it easier for church and community members to eat more fruits and vegetables, reduce fat intake, increase physical activity, and increase dietary intake of anti-inflammatory foods associated with colon cancer risk. this 12 week healthy eating and physical activity program is tailored to meet a church's needs and goals by: 1. providing cooking classes, recipes, 2. tips for increasing the level of physical activity in their daily routine 3. assistance tracking basic measurements like * weight * blood pressure, * inflammation levels education goals: * increase knowledge of health behavior and changes that can impact health status * increase confidence in sharing health information with church, family, and community members. * develop skills to facilitate behavior change * develop skills to overcome barriers to behavior change

Eligibility criteria:
inclusion criteria: * african american exclusion criteria: * history of cancer * history of ulcerative colitis * chrome disease

Keywords: inflammation
training therapists in motivational interviewing

Conditions: Spinal Cord Injuries

Summary: the purpose of this study is to test the efficacy of a motivational interviewing intervention on therapy participation as performed by physical and occupational therapists in an inpatient setting with patients with spinal cord injuries.

physical and occupational therapists that work in the inpatient spinal cord injury unit will be trained in motivational interviewing and will use the communication style to determine whether it is an effective tool to increase participation in therapy as opposed to patients who will have physical and occupational therapists that are not trained in motivational interviewing.

Eligibility criteria:
therapist inclusion criteria: * inpatient therapist specializing in spinal cord injury patients for at least 3 months * practicing on one of the two designated inpatient units * willing to collect patient rehabilitation participation scale (prps) daily on their patients * willing to audio record conversations with patients; * willing and able to participate in 16 hours of mi training * willing to receive feedback on mi skills therapist exclusion criteria: * inpatient therapist specializing in spinal cord injury patients for less than 3 months * unwilling or unable to follow the study protocol patient inclusion criteria: * inpatient in the spinal cord injury unit * has a physical or occupational therapist who is a participant in the study patient exclusion criteria: * unwilling to allow for therapy sessions to be recorded

Keywords: spinal cord injury motivational interviewing
nutritional intervention and dna damage of patients with hboc

Conditions: HBOC Syndrome; DNA Damage; Nutrition Therapy

Summary: breast and ovarian cancer syndrome (hboc) is characterized by mutations in tumor suppressor genes such as brca1 and brca2, which increase the carrier's risk of developing breast and ovarian cancer, especially before 40. in this pathology the dna damage is increased because there is a state of chronic inflammation, plus the antineoplastic treatments and changes in body composition result in oxidative stress. the inductions of epigenetic changes by a nutritional intervention with an specific distribution of macronutrients, micronutrients and polyphenols, not only ensures an optimal nutritional status, but also shows a decrease in oxidative stress, and therefore in dna damage. the aim of this study is to assess if the dna damage in patients with hboc decreases after the nutritional intervention.

breast and ovarian cancer syndrome (hboc) is a genetic disease characterized by mutations in tumor suppressor genes such as brca1 and brca2, elevation of reactive oxygen species (ros), inflammation and dna damage; all this as a result of the pathology itself. antineoplastic treatments and changes in body composition such as malnutrition, cachexia and obesity lead to an increase of the inflammatory state. the induction of epigenetic changes by a nutritional intervention suggests that an hypo caloric diet, complex carbohydrates, polyunsaturated fatty acids, some amino acids, and some vitamins, minerals and polyphenols as well, can reduce dna damage because of the interaction between mechanisms related with dna stability and reparation, cellular replication, induction of apoptosis, and antioxidant systems. previous studies report that using polyphenols supplements can reduce de dna damage, but when the administration is only through food there's no benefit at all. so the aim of this study is to assess if the use of different micronutrients and polyphenols in conjoint can make synergism and reduce de dna damage without the need of supplements.

Eligibility criteria:
inclusion criteria: * female patients diagnosed with hboc according to the mexican consensus of breast cancer * patients over 18 years who voluntarily agree to participate in the study and sign the informed consent. exclusion criteria: * patients with end-stage chronic kidney failure, heart failure, liver failure, rheumatoid arthritis, non-inherited ac or hiv. * patients who carry out a structured exercise plan (rehabilitation) at the time of inclusion in the study. * patients who carry out a structured eating plan (adherence to diet) or who are consuming a food supplement at the time of inclusion in the study. * patients with significant primary clinical disorders: hematological (hemoglobin \ 3), neurological (other than epilepsy).

Keywords: hboc syndrome dna damage nutrition therapy
fmt in ulcerative colitis-associated pouchitis

Conditions: Ulcerative Colitis Associated Pouchitis

Summary: the purpose of this study is to test whether fecal microbiota transplant (fmt) is a safe and effective treatment for people who have ulcerative colitis and have had an ileal pouch anastomosis. ulcerative colitis (uc) is a type of inflammatory bowel disease (ibd) that may be caused by a person's immune system responding in an unusual way to bacteria normally found in the gut. studies have shown that the gut bacteria in people with ulcerative colitis (uc) are different from the gut bacteria in people without ulcerative colitis (uc). often, people with ulcerative colitis (uc) have fewer types of bacteria in their gut which can change the way that person's immune system works. this study is for people who have had a proctocolectomy with an ileal pouch anastomosis (ipaa) to treat ulcerative colitis (uc). more than 50% of people who have had an ipaa will develop a condition called pouchitis. pouchitis is short or long-term inflammation of the ileal pouch that was created in order to store waste from your intestines. patients with pouchitis are being asked to take part in this study. currently, antibiotics, probiotics and prebiotics are used to treat pouchitis. however, it has been shown that probiotics are not very helpful once the patient stops taking them. in addition, antibiotics may cause unfavorable side effects. fecal microbiota transplantation (fmt) is being studied as another form of treatment for patients with active pouchitis. fecal microbiota transplantation (fmt) or "stool transplant" involves receiving a single fecal enema from someone who has volunteered to donate their stool. there are two purposes of this research study: 1. to see whether or not fecal microbiota transplantation (fmt) is a useful treatment for patients with ulcerative colitis (uc) associated pouchitis 2. to study the changes within the bacteria in the gut in patients with pouchitis (before and after study treatment) using stool, blood and urine samples


Eligibility criteria:
inclusion criteria: * male or female * age 18 to 65 years * ulcerative colitis-associated pouchitis * patients of emory clinic and/or emory university hospital exclusion criteria: * age \ 65 years of age * exposure to immunosuppressive therapy (defined as steroid, etanercept, or anti-tumor necrosis factor (tnf)agents) within 1 month prior to enrollment * concomitant clostridium difficile infection * suspected crohn's disease * documented active infection of any kind * patients on anti-coagulant therapy, with platelet count less than 50,000, significant anemia with hemoglobin less than 7 or those with other conditions that place them at increased risk of bleeding * absolute neutrophil count (anc) less than 1000 or history of opportunistic infection * administration of investigational drug within one month prior to planned fmt * pregnant or breastfeeding women

Keywords: ulcerative colitis fecal microbiota transplantation
italian prospective data collection for better patient characterization in a highly treatment experienced population

Conditions: HIV Infections

Summary: data collection for better patient characterization in a highly treatment experienced population. studying the clinical practice for the treatment of hiv multiexperienced patients in the real life. the research will be divided into two phases: * the first phase intends to define and understand the clinical practice using a questionnaire about general topics: definitions of multiexperienced patients and vl failure, therapeutic strategies and behaviour in particular cases. * the second part of the research will collect the clinical data of double pis failure patients.


Eligibility criteria:
inclusion criteria: patients double pis failure exclusion criteria: not applicable
electronic warning system for atrial fibrillation

Conditions: Atrial Fibrillation

Summary: the aim of this randomized controlled study is to evaluate whether a newly designed electronic warning system will increase the initiation rate of adequate stroke preventive measures in patients with atrial fibrillation.

a large proportion of patients with atrial fibrillation do not receive stroke prevention therapy in line with the guidelines, in spite of the presence of an increased risk of stroke. it will be investigated whether an electronic alert to physicians, whose patients with atrial fibrillation do not receive stroke preventive measures, will increase the rate of adequate stroke preventive measures as compared to a control group of patients without an electronic alert. the electronic alerts will be sent if patients with atrial fibrillation but without adequate stroke preventive measures receive in-patient treatment at the university hospital bern. the electronic alert system includes a feature that helps the physicians in charge to evaluate the cha2ds2vasc score. at the end of the hospital stay medical discharge letters will be reviewed for initiation of adequate stroke preventive measures.

Eligibility criteria:
inclusion criteria: * all in-patients with atrial fibrillation exclusion criteria: * ongoing anticoagulant therapy

Keywords: prevention anticoagulation electronic warning system
an open-label study to evaluate the effect of every other week procrit� (epoetin alfa) dosing (40,000-60,000 units) on maintaining quality of life and target hemoglobin levels in anemic hiv-infected patients (champs ii)

Conditions: Anemia; HIV Infections

Summary: the objective of this study was to treat anemic (hemoglobin (hb) \ 13 g/dl and then to assess if the target hb level and improvements in quality of life (qol) could be maintained with every other week (q2w) procrit (epoetin alfa) dosing.

this was a phase iv, open-label, non-randomized, multi-center study conducted in community based practices, physicians networks, or academic institutions in the us. this study included anemic (hb \< 12 g/dl) hiv-infected subjects and hiv/hepatitis c (hcv) co-infected subjects not receiving hcv treatment on a stable anti-retroviral therapy (art) regimen for at least 4 weeks prior to enrollment. quality of life assessments, laboratory results, and transfusion information were obtained during the study. laboratory tests, vital signs (blood pressure), and incidence and severity of adverse events were collected and assessed. the primary objective of this study was to assess if every other week procrit (epoetin alfa) dosing can maintain quality of life in anemic hiv-infected patients. the primary hypothesis of interest was that the mean quality of life score (as measured by mos-hiv general health perception score) at the end of the every other week (q2w) maintenance phase was not lower than that at the beginning of the maintenance phase by more than 7 points. it was anticipated that less frequent dosing, every other week, was more convenient for patients and will improve patient compliance. the starting dose (baseline/study day 1) of procrit (epoetin alfa) for all eligible subjects was 40,000 u given subcutaneously qw. the maximum duration was 24 weeks. subjects who achieved target hb levels \>= 13 g/dl were converted to a maintenance dose of procrit (epoetin alfa) sc q2w.

Eligibility criteria:
inclusion criteria: * understand and sign written informed consent * hiv-infected patients (as documented by hiv-rna values) * hiv/hcv co-infected patients not receiving treatment * hemoglobin \< 12 g/dl unrelated to transfusion * estimated life expectancy of \> 9 months * has been maintained on a stable antiretroviral regimen for at least four weeks prior to enrollment into this study. exclusion criteria: * acute, symptomatic opportunistic infection or other acute aids defining illness * anemia attributable to factors other than hiv infection (i.e., iron, b12 or folate deficiencies, hemolysis, gastrointestinal bleeding) * hcv co-infected patients who are anticipated to receive treatment with ribavirin/interferon during the study period. previous treatment with ribavirin/interferon must have been completed at least 12 weeks prior to study entry * ferritin level \< 40 ng/ml * uncontrolled or severe cardiovascular disease including recent (\< 6 months) myocardial infarction, uncontrolled hypertension or congestive heart failure

Keywords: anemia erythropoetin epoetin alfa erythropoetin recombinant hiv, aids
can a digital tooll facilitate shared decision-making and increase self-efficacy in vocational rehabilitation?

Conditions: Musculoskeletal Pain

Summary: the study investigates both the effects and the experienced value of the mobile application, mira, which is a combination of an electronic diary, a dialogue tool and a decision support tool. the individual user registers real-time data reported in a mobile application, e.g. pain, sleep, mood, social activities, work-related activities, based on the goals and condition of the individual user. in this study, users are citizens participating in vocational rehabilitation due to long term sick leave. the purpose of mira is to support a positive and trustful relationship between the citizen and the professional, and to enhance user involvement and shared decision making in the course of rehabilitation. this happens through promotion of the citizens knowledge and understanding of their own health condition and increase his or her self-efficacy, i.e. their ability to cope with their health condition at work and in everyday life. the study uses a combination of quantitative and qualitative methods, analysed both individually and in combination, where findings of the different methods are combined to provide a deeper understanding of the positive and negative effects of using mira in vocational rehabilitation. in this way the study investigates both the effect of applying a digital tool, such as mira, on a number of quantifiable measures (using questionnaires), and at the same time the study explores what works for whom and why using qualitative and combined methods. in this way, the study aims to contribute with knowledge in a balanced manner, regarding the pros and cons of using digital tools with real-time self-reported data in rehabilitation. the study aim will be fulfilled through the following sub-purposes: 1. to investigate the effect of using mira in a course of vocational rehabilitation in relation to the citizens' self-efficacy for pain and work and their experience of shared decision-making in the course of rehabilitation. 2. to investigate the citizens' experience with and perception of using a digital tool like mira in their course of rehabilitation. 3. to investigate the professionals' experience with and perception of using a digital tool like mira in the course of rehabilitation. 4. to investigate the mechanisms of effect of mira (i.e. what works for whom and why), through and integrated analysis of the findings of sub-purpose 1-3.


Eligibility criteria:
inclusion criteria: * referred for a course of vocational rehabilitation at a multidisciplinary health care unit at a municipal employment department. * on sick leave or unemployed due to musculoskeletal or stress-related disorders * in the working age (18 - 68 years approximately) exclusion criteria: * on sick leave or unemployed for other reasons, e.g. psychiatric disorders or cancer; * under the age of 18 or older than 68 years (approximately) * not sufficiently familiar with danish language to use the mira app as intended.

Keywords: rehabilitation, vocational telemedicine