Kornimate/medical-research-clean huggingface dataset:
magnetic resonance spectroscopic imaging of the prostate at 3 tesla

Conditions: Prostate Cancer; MRI

Summary: the purpose of this study is to determine the benefits of magnetic resonance imaging (mri) combined with magnetic resonance spectroscopic imaging (mrsi), on an instrument called a 3.0 tesla (t) mr scanner.


Eligibility criteria:
inclusion criteria: * patient must have clinically suspected or biopsy proven prostate cancer. if a patient has been diagnosed with prostate cancer an official report of biopsy from mskcc or outside site is required. all outside pathology reports will be confirmed at mskcc. * for those patients who have undergone prostate biopsy it is recommended that the interval between biopsy and protocol mri/mrsi should be at least 8 weeks. * patient is a potential surgical candidate for treatment of prostate cancer * patient is willing to undergo an endorectal mri/mrsi exam on the 3.0t mr scanner exclusion criteria: * patients who because of general medical or psychiatric condition, or physiologic status unrelated to the presence of prostate cancer cannot give valid informed consent. * patients who are unwilling or unable to undergo mri/mrsi (including patients with contra-indications to mri such as the presence of cardiac pacemakers or non-compatible intracranial vascular clips. * patients who cannot tolerate or have contra-indications to endorectal coil insertion; for example, patients who have had a prior abdominoperineal resection of the rectum or have crohn's disease, patients with severe hemorrhoids, patients who have had prior radiation to the pelvis to treat a malignancy, or patients who have had minor rectal surgery within the previous 8 weeks. * patients with an allergic reaction to latex. * patients with a metallic hip implant or any other metallic implant or device in the pelvis that might distort local magnetic field and compromise quality of mri/mrsi.

Keywords: prostate cancer cancer mri magnetic resonance imaging 06-035
reducing air pollution exposure to lower blood pressure among new york city public housing residents

Conditions: Blood Pressure

Summary: fine particulate matter \<2.5 µm (pm2.5) air pollution is the fifth leading risk factor for global mortality, with the largest portion of deaths due to cardiovascular disease (cvd). while several mechanisms are responsible, pm2.5-induced elevations in blood pressure (bp) may be relevant. indoor portable air cleaners (pacs) are a novel approach to reduce exposure to pm2.5 and potentially lower blood pressure. the current study is being conducted to provide evidence that pacs reduce pm2.5 exposure and lower systolic blood pressure (sbp) in key patient populations.


Eligibility criteria:
inclusion criteria: * self-reported nonsmokers living in a nonsmoking household. * adults living with hypertension (htn) from nyc public housing. exclusion criteria: * history of major known arrhythmias (e.g. atrial flutter or fibrillation, ventricular tachycardia). * screening systolic bp ≥160 mm hg or diastolic bp ≥100 mm hg (i.e. severe hypertension by the 2017 acc/aha bp guideline). * a change in drug regimen in the prior 2 weeks or a planned change in drug regimen during the first 30 days for those taking antihypertensive medication. * current smoking or living with an active smoker who smokes indoors * planned travel out of nyc for ≥2 weeks in next 6 months * incarcerated * pregnant * unable/unwilling to consent * established cardiovascular disease * end-stage renal disease (chronic kidney disease stage iv or on dialysis) * barrier to technology use (e.g., visual or hearing impairment) * lung disease requiring oxygen * cancer receiving treatment

Keywords: self-measured morning home systolic blood pressure (am h-sbp)
single center, open label, follow up study in subjects who previously received rabies vaccine as simulated post-exposure regimen

Conditions: Rabies

Summary: this study will evaluate the immunogenicity of rabies vaccine at 13 months, 3 year and 5 years after initial vaccination, administered in two different post-exposure vaccination schedules


Eligibility criteria:
inclusion criteria: * male and female subjects who received complete vaccine series in accordance to the designated vaccination schedule in the previous m49p8 study exclusion criteria: * any disease condition, that in the opinion of investigator may interfere with subjects ability to participate in the study. * receipt of additional doses of rabies vaccine after completion of initial vaccine series. * for additional entry criteria please refer to protocol.

Keywords: rabies vaccine long-term immunogenicity
preoperative carbohydrate loading in bariatric surgery

Conditions: Obesity, Morbid

Summary: the aim of this study is to perform a randomized non-blinded clinical trial to assess influence of preoperative carbohydrates loading in patients undergoing bariatric surgery measured by changes in the course of the postoperative period, changes in body composition and changes in insulin resistance


Eligibility criteria:
inclusion criteria: * obtaining written and informed patient consent. * no medical contraindications to perform a bariatric operation * no contraindications for the use of a rich carbohydrate drink exclusion criteria: * no consent to participate in the study * age under 18 years * the intolerance of the carbohydrate drink used in the test * the contraindications to perform bioimpedance measurements of body composition

Keywords: bariatric surgery carbohydrate loading insulin resistance
growth hormone during fasting.signaltransduktion in muscle and adipose tissue and changes in intrahepatic lipid content

Conditions: Metabolism; Fatty Liver

Summary: the purpose of this study is to examine the effects of growth hormone during fasting in healthy lean men.

during fasting the human body is known to metabolize relatively large amounts of fat, in the expense of proteins and glucose. partly this shift in metabolism is caused by increasing gh secretion, but exactly how growth hormone exerts these effects remains to be further investigated. 10 healthy lean young men are studied at 4 different occasions in a randomized single-blinded cross-over study. 1: after 12 hours of fasting + gh bolus, 2: after 36 hours of fasting + gh bolus, 3: after 36 hours + saline, 4: after 36 hours of fasting + somavert. aim: * to study the signal transduction in muscle and fat tissue * to study the metabolism during fasting * to study the intrahepatic fat content using magnetic resonance techniques

Eligibility criteria:
inclusion criteria: * male * healthy * age 20 - 40 years of age * bmi 20 -25 exclusion criteria: * uses any medication * drinks more than 21 units of alcohol per * is claustrophobic * carries any magnetic devices

Keywords: growth hormone fasting signaltransduction fatty liver insulin sensitivity forearm model protein metabolism respiratory quotient
optimal timing of hepatitis b vaccination after transplants

Conditions: Transplant-Related Disorder; Hepatitis B Virus Infection; Vaccine Reaction

Summary: the investigators aim to perform a randomized clinical trial to determine the optimal timing of hepatitis b vaccination after hematopoietic cell transplantation (hct) through evaluating the immunity effect of two different vaccination schedules (initiated at 3 or 6 months after transplantation) in patients with different immune reconstitution status.


Eligibility criteria:
inclusion criteria: 1. patients must be ≥ 16 years old; 2. patients receiving hematopoietic cell transplantation; 3. patients achieving complete molecular remission; 4. patients or their guardians have to sign an informed consent form before the start of the research procedure. exclusion criteria: 1. multiple transplantations; 2. donors' hbv-dna or hbsag are positive; 3. patients' hbv-dna or hbsag are positive before transplantation or \< 3 months after transplantation; 4. patients who are unable to comply with the research treatments and monitoring requirements due to mental or other medical conditions; 5. patients who are ineligible for the study due to other reasons which would cause unacceptable risks to the patients.
management of patients with type 2 diabetes and hypertension using mobile health care system

Conditions: Diabetes; Hypertension; Obesity

Summary: the purpose of this study is to determine whether cellular phone based health care system is effective in the treatment of diabetes and hypertension.

diabetes care is facilitated by a patient's being engaged in a self-management program with the advice and counsel of physicians, but many diabetic patients can not receive the continous monitoing and advice from his physician in their every day life. it is very difficult to keep up life style modification in their real life. few studies have examined the effects of cellular phone based intervention that provide an interactive component daily. our goal is to test the hypothesis that diabetes and hypertension management using cellular phone based health care system would result in significant improvement of blood glucose and blood pressure level.

Eligibility criteria:
inclusion criteria: * type ii diabetes using only oral hypoglycemic agents * 7% \< hba1c \< 10% * systolic blood pressure \> 130 or diastolic blood pressure \> 80 * bmi \> 23 * 20 \< age \< 75 exclusion criteria: * type i diabetes or type ii diabtes using insulin treatment * liver, renal or heart disease * recent change (within 1 month) in the type or dosage of anti-diabetic agent, anti-hypertensive medication

Keywords: mobile health units chronic disease
validity of turkish version of abc scale in diabetes mellitus patients

Conditions: Diabetes Mellitus; Balance; Distorted; Evaluations, Diagnostic Self

Summary: activities-specific balance confidence (abc) scale is a well-known tool to evaluate functional balance. diabetic patients suffer more often from balance disorders than the rest of the population. the aim is to investigate the validity of the turkish version of abc short form in patients with diabetes mellitus (dm).

thirty patients with dm will be included according to the inclusion and exclusion criteria. all the participants will be evaluated by abc form and timed up and go test (tug). the cumulative illness rating scale (cirs ) will be used for all the patients. abc scale is a self-assessment test with 16 items that helps assess balance impairments and falling risk, and it also investigates how confident people are while they are in some specific activities both indoors, and outdoors. total score changes between 0-100. the hba1c values of all patients will be noted if a blood test will be performed in the last three months.

Eligibility criteria:
inclusion criteria: * 45-75 years old * diabetes mellitus * the complete existence of the data to be used in the study in the records of our hospital exclusion criteria: * not having any other additional disease that will affect balance coordination * no lower extremity joint replacement or lower extremity amputation at any level

Keywords: balance diabetes mellitus
the effects of nutrition supplementation and resistance exercise during hemodialysis

Conditions: End Stage Renal Disease

Summary: to test the hypothesis that an exercise session combined with adequate nutritional supplementation improves skeletal muscle protein accretion during a hemodialysis session.


Eligibility criteria:
inclusion criteria: * on hemodialysis for more than 3 months, on a thrice weekly hemodialysis program. * adequately dialyzed (kt/v \> 1.2). * age 18-75 exclusion criteria: * pregnant women. * patients unable to perform exercise * severe unstable underlying disease besides commonly associated with esrd. cardiac patients that are stable will be included. * patients hospitalized within the last month prior to the study. * patients with malfunctioning arterial-venous access (recirculation and/or blood flow \< 750 ml/min) * patients receiving steroids and/or other immunosuppressive agents.
an evaluation of the safety and efficacy of lipo-102 for the reduction of subcutaneous abdominal adiposity

Conditions: Subcutaneous Abdominal Adiposity

Summary: this is a double-masked evaluation of the safety and efficacy of lipo-102 for the reduction of subcutaneous abdominal adiposity.


Eligibility criteria:
inclusion criteria: * male or non pregnant female * good general health * sufficient abdominal fat for injections * signed informed consent * bmi greater than or equal to 18 and less than 28 kg/m2 * history of stable weight in past 3 months exclusion criteria: * known hypersensitivity to study drugs * treatment with an investigational agent within 30 days of first dose

Keywords: subcutaneous adipose tissue reduction
nanos neck preserving hip stem

Conditions: Primary Osteoarthritis; Secondary Osteoarthritis; Dysplasia Osteoarthritis; Avascular Femoral Neck Necrosis; Post-Traumatic Femoral Neck Necrosis; Intact Femoral Neck With Good Bone Quality

Summary: the objective of this study is to determine the long-term safety and effectiveness of the nanos neck preserving stem in terms of radiographic and clinical performance as well as short-, mid- and long-term survivorship

the goal of this multicenter clinical observation is to validate short-, mid-, and long-term outcome (efficacy and safety) of the nanos neck preserving hip stem. effectiveness measures: * evaluation of function, range of motion (rom) and pain as assessed by harris hip score, hoos score \[4-6\], ucla activity rating \[7\] * radiographic changes as defined by radiolucent lines, osteolysis, hypo- and hypertrophy, implant loosening or migration safety evaluations: * intra- and peri-operative device-related adverse events (ae) and complications up to discharge * postoperative ae up to 10 years

Eligibility criteria:
inclusion criteria: * inclusion criteria: * patient requires primary total hip replacement (thr) to the affected side, unilateral or bilateral. bilateral only if \>3 months after the first thr * patient agreed to participate in the mco study by signing the informed consent form. * age of patient at date of surgery 18 to 65 years * patient is likely to comply with study follow-up requirements exclusion criteria: * previously failed endoprosthesis and /or thr components in relevant hip * patient has proven osteoporosis * pronounced coxa valga with a femoral neck angle \> 145º * pronounced coxa vara with a femoral neck angle \< 125º * history of infection in the affected joint; systemic infections * grossly insufficient femoral or acetabular bone stock in the involved hip where a revision cup is indicated * spinal disease with neurologic movement disorders * alcoholism or addictive disorders * asa score is 3 or 4 * body mass index (bmi) \> 30 * patient is pregnant or being pregnant during follow up intervals * patients understanding of the language is insufficient for understanding the patient information and consent

Keywords: nanos hip neck preserving stem
efficacy of proximal caries infiltration

Conditions: Dental Health; Caries

Summary: the goal of the project is to investigate the clinical efficacy of management of early caries lesions by resin infiltration and to further scrutinize the patient stress experiences.

the aim of this study is to test the clinical efficacy of caries infiltration to arrest proximal caries lesions in primary molars. it was hypothesized that infiltrated lesions (test lesions) will progress significantly less than non infiltrated lesions (control lesions). additionally, it was hypothesized that dental anxiety and stress related to caries infiltration will be significantly less than dental anxiety related to a conventional restorative procedure. the study will be a controlled clinical trial with a split mouth design and blind evaluation of the outcome (caries progression). caries progression will be evaluated annually, 12, 24, and 36 months after treatment.

Eligibility criteria:
inclusion criteria: * children with one tooth surface with active caries lesions * two primary molars with proximal lesion detected on the x-ray (scores 2 (e2) or 3 (d1) in mejàre et al. scoring system with less depth * asigned informed consent. exclusion criteria: * children who do not cooperate during dental appointments * primary molars supposed to exfoliate in less than two years * lesions showing obvious cavitation or clear sings of inactivity

Keywords: caries infiltration caries arrest dental anxiety dental stress resin infiltration
freeze all on oocyte maturatin by gonadotropin agonist versus human chorionic gonadotroipin

Conditions: Infertility

Summary: estradiol valerate in the form of cycloprogenova™ (white tablet only) was started on day 2 or 3 of cycle with oral dose 4 mg divided on 2 doses in addition to aspocid 75 mg once daily with folic acid 500 mcg once daily.

u/s was done on day 9 or 10 of cycle to assess endometrial thickness, then every other day until endometrial thickness of 8 mm or more is reached and when endometrial thickness reaches 8 mm or more fet was planned. progesterone in the form of prontogest™ 400 mg vaginal suppository twice dtwo to four day 5 embryos was transferred

Eligibility criteria:
inclusion criteria: * pcos patients according to rotterdam criteria * female age between 20 and 40 years. * primary or secondary infertility. * body mass index (bmi) between 18 and 40 kg/m2. exclusion criteria: * ovarian endometriosis. * ovarian cysts before induction. * known uncontrolled endocrinal abnormalities (like hypo or hyperthyroidism)
implant system for fixation of cranial bone flaps after craniotomy for brain surgery

Conditions: Skull Fixation After Craniotomy for Neurosurgical Procedures

Summary: bone flaps after craniotomy are typically fixed with suture material, mini plates and others devices. in some cases, fixation with suture material is not secure as it may result in shifting of the bone flap with its dislocation. we will test the safety and efficacy of skull grip a new device for fixation of the bone flap during cranial procedure comparing to traditional suture materials.

at the end of the operation to start the fixation of cranial bone flaps, at least three skull grip titanium clamps will be positioned equidistant to one another along the craniotomy opening. the lower parts (complete circle) will be inserted between the dura and the cranium. the linear parts of the superior semicircle have to be in line with the craniotomy borders to allow the lodging of the bone flap. the different heights of the device are finalized to suit it for the different thickness of the cranial vault. the same procedure will be performed with all remaining skull grip titanium clamps.the bone flap will be then placed in its original position. by using a forceps, a simple and easy clockwise rotation of the superior semicircle will allow to block the skull grip clamp in place. for simple removal if necessary of the skull grip titanium clamps, even if bone ossification of the craniotomy edges has already occurred, it will be necessary just to lift up the superior semicircle of the skull grip by a forceps and to cut by a cutting forceps the pin between the two circle. then, craniotomy could be completed in a standard way.

Eligibility criteria:
inclusion criteria: 1. major patient (aged ≥ 18 years) 2. patient scheduled for craniotomy for a benign tumor 3. patient informed and have signed informed consent exclusion criteria: 1. patient not affiliated with a social security scheme (or beneficiary entitled) 2. patient with a known allergy to titanium 3. patient non-compliant or whose follow-up to 3 months is impossible 4. patient with against-indication scanner 5. pregnant or lactating

Keywords: craniotomy skull fixation skull grip reconstructive cranial surgery
folfiri as third line of treatment

Conditions: Gastric Cancer; Ramucirumab; Third Line

Summary: the aim of this study is to investigate the activity of folfiri as third line of treatment in mgc progressed after ramuciramb-based second line.


Eligibility criteria:
inclusion criteria: * patients with histologically confirmed, ramucirumab pretreated metastatic gastric cancer who received * eastern cooperative oncology group performance status ≤2 (ecog ps) * aged \> 18 years * neutrophil count ≥1500/μl * platelet count ≥100 000/μl), * renal (serum creatinine ≤1.5 mg/dl) * liver (serum bilirubin ≤2 mg/dl) functions * normal cardiac function, * absence of second primary tumor other than non-melanoma skin cancer * no concurrent uncontrolled medical illness. exclusion criteria: * eastern cooperative oncology group performance status \>2 (ecog ps) * no prior treatment with ramucirumab * operable metastatic disease were excluded from the study * severe cardiac dysfunction, congestive heart failure or a recent myocardial infarction * uncontrolled sites of infection.
a study of xeloda (capecitabine) in women with high-risk breast cancer

Conditions: Breast Cancer

Summary: this 2 arm study will compare the efficacy and safety of taxotere + xeloda, versus taxotere alone, following a regimen of adriamycin plus cytoxan in women with high-risk breast cancer. following 4 cycles of adriamycin and cytoxan, patients will be randomized to receive either 1)taxotere 75mg/m2 iv on day 1 and xeloda 825mg/m2 po bid on days 1-14 of each 3 week cycle or 2) taxotere 100mg/m2 iv alone on day 1 of each 3 week cycle. the anticipated time on study treatment is until disease progression, and the target sample size is 500+ individuals.


Eligibility criteria:
inclusion criteria: * female patients 18-70 years of age; * adenocarcinoma of the breast; * previous invasive breast cancer if diagnosed \>5 years before entering study; * no evidence of metastatic disease. exclusion criteria: * history of severe hypersensitivity reaction to taxotere; * previous treatment with anthracycline, anthracenedione (mitoxantrone), or taxane; * treatment with fluoropyrimidine (5-fluorouracil) within the last 5 years.
influenza a h1n1: retrospective analysis of pcr confirmed cases of h1n1 infections in styria - risk factors, clinical features and outcome.

Conditions: Clinically Suspected H1N1 Infection

Summary: this retrospective study will analyse all pcr-proven h1n1 cases from the influenza season 2009/2010 treated within the styrian "lkh hospital network". for this purpose all pcr-positive case files are reviewed in medocs (electronic patients database) and data regarding clinical presentation, laboratory and radiological findings, treatment, outcome and preexisting underlying chronic illnesses will be systematically collected. in a second step the same data collection will be performed in a group of pcr-negative patients, which were tested during the influenza season 2009/2010 for influenza-like illness. the data from the pcr-positive group will be compared to the data from the pcr-negative group. we expect significant differences between the proven and unproven group regarding the primary presentation at hospital. based on these results a clinical score will be developed. this score should improve h1n1 case identification in emergency departments, even if specific diagnostic test are negative (rapid antigen testing) or still pending (pcr), reduce the number of missed hospitalized h1n1 infection and optimize the decision making process in emergency departments regarding which patient has to be admitted with infection control measures and which not, and as infection control measures are expensive (face masks, gloves) and limited (isolation room), such a score should also reduce unnecessary expense. to evaluate the sensitivity and specificity of the score a prospective study will follow in the influenza season 2010/2011.


Eligibility criteria:
inclusion criteria: * inclusion criteria: 1. all patients tested for influenza illness by pcr of respiratory tract specimens at the institute of hygiene, karl-franzens-university graz, and at the institute for hospital hygiene and microbiology, kages graz. 2. stratification according to the following definition: * pcr-negative influenza-like illness (ili) is defined as febrile illness tested by pcr for the presence of influenza infection but finally not proved as influenza infection. * influenza illness is defined as febrile illness confirmed by positive pcr as true influenza infection. exclusion criteria: * none