Kornimate/medical-research-clean huggingface dataset:
mechanisms of massage

Conditions: Healthy; Pain

Summary: the investigators have previously found moderately painful massage produces comparable changes in pain sensitivity as a conditioned pain modulation paradigm in healthy participants suggesting shared underlying mechanisms. the researchers aim to extend these findings by understanding the influence of expectation on these findings.

massage is a muscle biased intervention individuals seek for pain alleviation; however, the mechanisms of massage are not well established. in this study, the investigators aim to determine the effect of expectations on massage related hypoalgesia. individuals meeting eligibility criteria and agreeing to participate will attend one session that lasts approximately one hour. a myofascial trigger point (taut band of muscle tissue) will be assessed on the neck of the participant. next, a baseline assessment of pressure pain threshold will be performed followed by random assignment to one of four study arms.

Eligibility criteria:
inclusion criteria: * pain free exclusion criteria: * non-english speaking * systemic medical condition known to affect sensation (i.e. diabetes) * regular use of prescription pain medication to manage pain * current or history of chronic pain condition * currently using blood thinning medication * any blood clotting disorder such as hemophilia
laval university rouge et or post acl surgery program effectiveness

Conditions: Anterior Cruciate Ligament Injuries; ACL

Summary: the main objective is to compare the effectiveness of two readaptation programs post anterior cruciate ligament surgery. laval university rouge et or program is to be compared with the intervention guide from the chu. amateur athletes are recruited 3 months post acl surgery. the level of confidence, symptoms, functional recovery level and muscle strength are assessed and compared between the two groups at 3, 4, 5, 6 and 9-month post surgery.

it is experimental research with pre-post repeated measure with a control group. the subjects are randomised either in the intervention group (gr proro-ul) or the control group (gr chu-cp). the assessor is blinded to the randomisation. both groups receive their program at the first assessment at three months post-acl-surgery. they are strongly encouraged to continue their follow-up in physiotherapy to ensure the program is suitable to their individual progression. the participants are assessed again at 4, 5, 6 and 9 months post surgery to measure their progression. a weekly journal sent by e-mail is to be filled to ensure the subjects train according to their program attribution. it is a randomised control trial with a blinded assessor.

Eligibility criteria:
inclusion criteria: * amateur athlete aged from 18 to 35 years old doing sports at least 3 times a week * having suffered from an anterior cruciate ligament rupture * having undergone anterior cruciate ligament surgery either with an anterior approach (with the patellar tendon) or a posterior approach (with the semitendinosus tendon) * having a functional deficit (score 85% or under at knee outcome survey - activity of daily living scale questionnaire and/or score 80% or under at international knee documentation committee questionnaire) * being available for follow up and actively follow the programme attributed. exclusion criteria: * having suffered from multiple surgery for other ligaments in the same knee. * having undergone total meniscus removal * having suffered form posterior cruciate ligament rupture. * having other injuries that could affect the functional performance and prevent from training.

Keywords: acl anterior cruciate ligament post surgery
european myeloma network (emn) sample project

Conditions: Multiple Myeloma; Smoldering Multiple Myeloma; Plasma Cell Leukemia; Extramedullary Myeloma; MGUS

Summary: this is an observational, non-interventional, multicenter study for the prospective collection, storage and analysis of patients' biological samples. this study establishes a common international infrastructure useful to collect standard clinical variables at baseline and during treatment and to uniformly collect and store biological samples


Eligibility criteria:
inclusion criteria: * subjects with mgus, smouldering multiple myeloma (smm) , mm (multiple myeloma) (+/- emd), plasma cell leukemia (pcl) (+/- emd) * subjects are ≥ 18 years old. * subjects have provided written informed consent in accordance with federal, local, and institutional guidelines prior to initiation of any project-specific activities or procedures. 1. subjects do not have kind of condition that, in the opinion of the investigators, may compromise the ability of the subjects to give written informed consent and 2. subjects are, in the investigator's opinion, willing and able to comply with the protocol requirements. exclusion criteria: * previous treatment with anti-myeloma therapy (excluding one course of therapy in patients in which urgent therapy is deemed necessary according to physician's discretion, e.g. myeloma-related complications resistant to supportive care). * subjects have had prior unforeseen (serious) adverse reactions to blood donation including, but not limited to fainting, angina, severe bruising, allergic reactions, or any other adverse events. * any psychological, familial, sociological and geographical condition potentially hampering compliance with the protocol and follow-up schedule.
intradermal versus intramuscular polio vaccine booster in hiv-infected subjects

Conditions: Polio Immunity

Summary: the purpose of this study is to determine whether a lower dose of inactivated polio vaccine (ipv) injected into the skin (intradermal administration) can work equally well or better than the standard dose injected into the muscle (intramuscular administration). there are more immune cells in the skin than in the muscle, and other vaccines have been shown to require a lower dose when administered intradermally. the study is being done in participants infected with hiv because hiv-infected people are known to respond less well to vaccines than other groups, so it is particularly important to know if ipv might work better in hiv-infected people if administered intradermally. if it is possible to lower the dose of ipv by intradermal administration, this would make inactivated polio vaccine more affordable in the developing countries where it is most needed

oral polio vaccine (opv) will not be sufficient to eradicate polio. opv has failed to provide adequate polio immunity in certain immunocompromised populations, such as people with aids. also, opv can mutate and form neurovirulent strains capable of causing polio outbreaks. inactivated polio vaccine (ipv), which cannot mutate into neurovirulent strains and which is more effective in populations that have failed to respond to opv, will be needed globally to eradicate polio, but it is unaffordable for many developing countries. because there are more immune cells in the skin than in the muscle, intradermal administration of ipv may be a way to increase the efficacy and reduce the dose (and thus the cost) of ipv. we plan to conduct a clinical trial randomizing 231 hiv-infected adults to receive a booster of two-fifths dose intradermal ipv, one-fifth dose intradermal ipv, full dose intramuscular ipv, or two-fifths dose intramuscular ipv. we will measure polio immunity before and after vaccine administration. through this study, we will determine the optimal booster dose of intradermal ipv, whether intradermal works better than intramuscular ipv administration, and whether intradermal ipv is effective in an immunocompromised population. the data from this trial could contribute to global polio eradication.

Eligibility criteria:
inclusion criteria: * documented hiv infection * age of at least 18 years old * hiv viral load \<400 on the most recent test exclusion criteria: * current acute moderate to severe illness (demonstrated by fever over 100.4 fahrenheit, shortness of breath, altered mental status, or by judgment of the primary clinician) * current pregnancy * history of allergic reaction to a polio shot, * history of a life-threatening allergic reaction to neomycin, streptomycin, or polymyxin b
changes in cardiac deformation following physiologic alterations and inotropic support.

Conditions: Heart Failure, Diastolic; Aortic Valve Stenosis; Monitoring, Physiologic; Physiology

Summary: the investigators want to compare the effects of two drugs, levosimendan and milrinone, on cardiac muscle, both in terms of contractility and relaxation. half of the participants will be randomized to each drug. the effects will be measured through echocardiographic deformation analyses. since deformation analyses could be dependent on different loading conditions of the heart, a second purpose of the study is to investigate the changes on deformation parameters after applied changes in preload and afterload, but also heart rate.

aortic stenosis is associated with myocardial hypertrophy and diastolic dysfunction. in patients undergoing open aortic valve replacement surgery due to stenosis, the investigators want to compare the effect on myocardial relaxation between two commonly used drugs, levosimendan and milrinone, using catheter-based measurements in combination with echocardiographic evaluation. standard anaesthesia and surgical care for these patients is performed. after surgery is completed and the participant is transferred to the intensive care unit, the studies are performed during general anaesthesia and the participants still connected to a respirator with controlled ventilation. echocardiographic data will be collected simultaneously with hemodynamic parameters - first at two control measurements, then after each of two different doses of the drug. preload, afterload and heart rate will be kept stable during this intervention. the echocardiographic data is later analyzed offline for strain and strain rate. to further investigate the dependency of strain and strain rate on changes in preload, afterload, and heart rate, these variables are consecutively changed prior to drug administration. for this purpose, all patients first have their baseline data recorded, thereafter are paced at two different rates, then preload and afterload is altered by passive leg elevation and phenylephrine, respectively. hemodynamic and echocardiographic data are collected simultaneously at baseline and after each intervention. before administration of the drugs, baseline conditions are restored.

Eligibility criteria:
inclusion criteria: * subject has aortic valve stenosis * subject is scheduled for open heart aortic valve replacement with or without simultaneous coronary artery bypass grafting exclusion criteria: * less than normal systolic function, defined as ejection fraction less than 0,5 * non-sinus rhythm * any major surgical complication * problems understanding the informed consent

Keywords: transesophageal echocardiography milrinone levosimendan strain deformation diastole afterload preload systole
a study to learn about the effectiveness of the medicine called elranatamab in people with relapsed refractory multiple myeloma

Conditions: Multiple Myeloma

Summary: this study is to understand how well elranatamab (pf-06863135) may be used for relapsed refractory multiple myeloma (rrmm). sometimes mm might improve at first, but then gets resistant to the treatment and starts growing again (known as relapsed refractory). this study medicine will be compared with standard-of-care (soc) therapies used in real-world clinical practice. for people receiving elranatamab, the investigators will use data from the phase 2 clinical trial (magnetismm-3). the investigators will also use data from multiple real-world sources, representing the soc in clinical practice. this study does not seek any participants for enrollment. the investigators will compare the experiences of people receiving elranatamab to people receiving soc therapies. this way, it will help the investigators to know how well elranatamab can be used for rrmm treatment.


Eligibility criteria:
inclusion criteria: * aged 18 years and older at index date * diagnosis of mm * measurable disease according to imwg criteria * ecog performance status ≤2 * refractory to at least 1 proteasome inhibitor, 1 immunomodulatory drug, and 1 anti-cd38 treatment (ie, triple-class refractory \[tcr\]) * at least 1 treatment following their tcr eligibility exclusion criteria: * acute plasma cell leukemia * amyloidosis * smoldering mm * stem cell transplant within 12 weeks of index or active graft versus host disease (gvhd) * active malignancy within 3 years before index, except for basal cell or squamous cell skin cancer or carcinoma in situ * administration with an investigational drug within 30 days prior to index

Keywords: myeloma multiple myeloma relapsed multiple myeloma refractory multiple myeloma pf-06863135 bcma bispecific bispecific antibody bcma-cd3 bispecific elranatamab magnetismm-3
prevalence of clopidogrel (plavix) resistance in hemodialysis patients

Conditions: Cardiovascular Disease

Summary: the investigators are trying to find out if clopidogrel (plavix) is as effective in hemodialysis patients as in patients not hemodialysed.

cardiovascular disease is very frequent in hemodialysis patients. lot of hemodialysis patients are on clopidogrel (plavix). their is some evidence that clopidogrel is not effective in hemodialysis as it is effective in patient without kidney problem. verifynow plavix is a machine that measure the ability of the blood to clot after giving plavix. we will collect blood from hemodialysis patients on plavix and check the ability of their blood to clot and thus indirectly measuring the efficacy of plavix.

Eligibility criteria:
inclusion criteria: * all patients on hemodialysis taking plavix exclusion criteria: * known to have bleeding disorder * severely anemic with hemoglobin level (hb) \< 10g/dl * low platelets \< 10000

Keywords: plavix or clopidogrel resistance
evaluation of the strength of handgrip in patients with pulmonary artery hypertension

Conditions: Pulmonary Hypertension

Summary: our study aims to investigate the changes in muscle strength and muscle mass in pah patients compared to healthy individuals and determine its effects on prognosis. further categorization of pah patients based on their nyha class will help determine if their handgrip strength decreases while progressing from nyha class 1 to 4. this in turn allows us to examine if the handgrip test can be considered as an alternative to a 6-minute walking test (6mwt). the jamar hydraulic hand dynamometer device in our hospital is used for measuring the handgrip strength test. the data of the included subjects in this study are obtained and recorded from the existing files. also, the handgrip strength test data will be recorded after the investigation

in our study, dynamometer tests will be applied to approximately 15 patients diagnosed with pah. for control purposes, a hand dynamometer test will be applied to 40 healthy children. patients' age, gender, weight, height, nyha class, used medications, complete blood count (hb, hct, mcv, rdw), bnp, troponin-t, biochemical parameters, catheterization findings at diagnosis, echocardiographic findings (tricuspid annular plane systolic excursion-tapse), right ventricular end systolic remodeling index (rves-ri), pulmonary artery acceleration time (paacct), tricuspid velocity time integral (tr-vti), rv area, rv length, right ventricular load adaptation index (rv lai), congenital heart disease and whether there is a shunt recorded or not. patients are informed about the test before the dynamometer test. this may affect the integrity and accuracy of test results. to prevent such inaccuracies, the test will be performed on patients' both hands and the results are not recorded. patients are asked to sit in a specific position. that is to sit upright with their elbows flexed 90° and the palms facing inwards (medially). then, the test is performed 3 times with both hands. the results are recorded as the average of all the trials for dominant and non-dominant hands separately. the length of patients' hands is also measured. with the help of this test,it is possible to measure the difference in handgrip strength between healthy subjects and pah patients. additionally, patients are divided into 4 groups based on their nyha classes. this will investigate if the patients' handgrip strength decreases as progress from nyha class 1 to 4

Eligibility criteria:
inclusion criteria: pulmonary hypertension group: * diagnosed with pulmonary hypertension and attending the clinic for follow-ups. * older than 5 years. healthy control group * individuals without any known diseases, structural cardiac anomalies, familial history of heart diseases and sudden death. * older than 5 years. exclusion criteria: volunteers' rejection criteria: * younger than 5 years. * mental state disorders which will cause inaccuracies in the study's i. volunteers' dismissal criteria: * inadaptation to the study's steps. * if subjects become reluctant to continue with the study.

Keywords: handgrip functional status
comparison between the effect of ultrasound debridement and conventional treatment in diabetic foot ulcers (dfu).

Conditions: Diabetic Foot Ulcer

Summary: the investigators aimed to elucidate the effects of ultrasound debridement on the area and healing of diabetic foot ulcers compared to their conventional treatment.


Eligibility criteria:
inclusion criteria: * male and female patients ≥18 years old. * type 1 or type 2 diabetes mellitus with hba1c ≤ 10%. * dfu grades ia, iia, ib, iib, ic, iic, id, iid, according to the university of texas classification. * dfu grades pedis 1-absence of infection, pedis 2-mild infection and pedis 3-moderate infection, according to the pedis-idsa classification. * wound size between 1 cm² and 30 cm². * evolution time dfu between 1 and 24 months. * ankle-brachial index (abi) ≤0.9 and ankle systolic blood pressure (asbp) ≥70mmhg, or toe systolic blood pressure (tsbp) ≥50mmhg, abi\>0.9, tsbp ≥50mmhg and toe-brachial index (tbi) ≤0.7 exclusion criteria: * critical limb ischemia patients with abi≤0.5 and asbp\<70mmhg or tsbp\<50mmhg. * clinical suspicion of osteomyelitis. * pregnant or lactating women or women of childbearing potential who are not using effective contraception. * patients diagnosed with hepatitis or human immunodeficiency virus (hiv)

Keywords: diabetic foot diabetic foot ulcer ultrasound debridement ultrasonic debridement
reduce speed limits from 90km/h to 80 km/h on french roads: impact on mortality

Conditions: Health Risks; Death

Summary: on the first july 2018, the french government lowered the maximum authorized speeds on two-way roads without a central separator from 90 km/h to 80 km/h. the network concerned represents approximately 400 000 km of roads outside the built-up area, accounting for 55% of road deaths. the objective of the measure is to reduce the number of deaths on the roads concerned by encouraging the reduction of the average speed practiced by drivers. the analysis deals with a comparison of the number of killed persons on the network concerned, before and after the reduction of the speed limits. the "before" period is 2015-2017. the "after" period is from july 2018 to june 2019. the data used are extracted from the national bodily injury accident file (baac). the police fills this file for each road accidents occurring on a road open to public traffic and causing at least one victim (i.e., one user requiring medical care and involving at least one vehicle).

this measure was intended general and concerns a type of roads in its entirety. the rest of the road network is too heterogeneous (urban, highways ...), leading to an accidentology very far in terms of severity, users concerned and families of accidents to allow the establishment of control groups that would not be affected by a reduction in the speed limit. as a result, the principle of an assessment of "before-and-after" effects has been retained.

Eligibility criteria:
inclusion criteria: * people who circulate on french non-motorway non-urban roads during the period of the study * any person who dies in a road accident on this network during the period of the study, who either dies instantly or within 30 days of the accident, due to the consequences of the accident exclusion criteria: * all persons involved in an accident on a private road * all persons involved in a road accident without a motor vehicle

Keywords: speed road safety
sensory perceptual training on activities of daily living and hand functions

Conditions: Cerebral Palsy, Spastic

Summary: many risk factors can come to the fore in cp. with the new studies on cp, new risk factors are defined and existing risks are better understood. in the light of current information, general risk factors for cp are defined as premature birth, fetal growth restriction, multiple pregnancies, infections in the fetal or neonatal period, birth asphyxia, perinatal stroke, and congenital developmental disorders in addition, related risk factors are classified as prenatal, perinatal and postnatal

children and youth with cerebral palsy face unique challenges when learning, practicing, and mastering activities of daily living (adls). active participation in dressing, feeding, toileting, clothing management, and small space mobility is influenced by body structures and function and environmental and personal factors

Eligibility criteria:
inclusion criteria: * modified ashworth 1 and 1 + * gmfcs level i and ii * able to understand and follow instructions exclusion criteria: * fixed contracture or deformities in the spine or extremities * visual or respiratory problems, * orthopedic surgery