Kornimate/medical-research-clean huggingface dataset:
development of a novel human in vitro sarcoidosis model

Conditions: Sarcoidosis

Summary: there is currently no experimental model that accurately represents sarcoidosis. the lack of a useful research model significantly slows progress towards developing new treatments for sarcoidosis. the investigators plan to develop a new model for sarcoidosis research and will test the model to see if it helps us understand how sarcoidosis develops and if it is useful for testing new treatments.

sarcoidosis is a systemic granulomatous disease of unknown cause, most commonly affecting the lungs, which tends to afflict young adults in the prime of their lives. recent data indicating that sarcoidosis mortality rates are rising in the u.s. (1) and europe (2) highlight the inadequacy of current therapies. as noted in a recent nih-sponsored sarcoidosis workshop, the lack of relevant animal, computer or in vitro models represents a bottleneck for progress towards understanding disease mechanisms and developing highly effective sarcoidosis treatments (3). the lack of useful disease models likely contributes to the current lack (zero) of investigator-initiated (ro1) projects supporting sarcoidosis research. the long-term goal of this proposal is to develop a novel human sarcoidosis research model to fill the current void in the field, thereby expediting exploration of basic disease mechanisms and pre-clinical testing of novel therapies. the objective of this application, which is the first step towards achieving the long-term goal, is to develop a novel in vitro human granuloma model to represent abnormal granuloma formation in the context of sarcoidosis. in this regard, a growing body of evidence indicates that mycobacterial antigens are commonly harbored in sarcoidosis tissues, to which these patients are sensitized (4, 5). our central hypothesis is that the pathological mechanisms of sarcoidosis can be modeled in vitro, as represented by abnormal granuloma formation in response to mycobacterial and other ubiquitous environmental antigens. the feasibility of our proposed model is supported by preliminary studies showing that subjects sensitized to mycobacterium tuberculosis antigens (latent tb tuberculosis with a positive tb skin test) form well-organized granulomas readily in response to challenge with tb antigens, compared to healthy controls. this project is highly innovative and we feel has an excellent likelihood of leading to a critical breakthrough in the field of sarcoidosis research.

Eligibility criteria:
inclusion criteria: * sarcoidosis, subjects (18 - 45 years of age), including 30 sarcoidosis, 15 latent tb and 15 healthy controls. exclusion criteria: * pregnant women
a study to compare lbvd to eupenta and imovax polio in healthy adults

Conditions: Diphtheria; Tetanus; Pertussis; Poliomyelitis; Hepatitis B; Haemophilus Influenzae Type b Infection

Summary: this is a single-center, randomized, active-controlled, parallel-group, open-label, phase i study to evaluate safety and immunogenicity of single injection of lbvd or eupenta co-administered with imovax polio in healthy adults.


Eligibility criteria:
inclusion criteria: 1. healthy adults between 19 and 55 years of age at the time of visit 1 (screening) 2. persons who or whose legal representatives have voluntarily signed an informed consent after receiving explanation about the objectives, methods, effects, etc. of the clinical study 3. persons who are surgically sterile, postmenopausal women, or agree to use contraceptive measures exclusion criteria: 1. persons who have an experience of participation in another interventional clinical study within 3 months prior to visit 1 (screening) 2. persons who have a record of vaccination with the tetanus toxoid (tt)/tetanus diphtheria (td)/tetanus diphtheria pertussis (tdap) vaccine or other vaccines containing tetanus-diphtheria for adults or who are suspected to have been vaccinated with either of them within 5 years prior to visit 1 (screening) 3. persons who were vaccinated within 4 weeks prior to visit 1 (screening) or who are scheduled to be vaccinated with the vaccines other than the study vaccine during the study period 4. persons with a history of diphtheria, tetanus, pertussis, hepatitis b virus, polio virus, or the invasive diseases caused by haemophilus influenzae type b
impact of inflammation biomarkers on the acute respiratory distress syndrome (ards) definition

Conditions: Acute Respiratory Distress Syndrome

Summary: the ards has a clinical definition with criteria of the american-european consensus conference (1994). this definition inconveniently applies to a lot of patients with acute respiratory failure. we know that there are 2 forms of ards morphology on ct scan : "lobar attenuation" (loss of aeration with no concomitant excess in lung tissue) predominating in the lower lobes and "non lobar attenuation" with diffuse and massive loss of aeration with excess lung tissue in all the pulmonary parenchyma. today, plasmatic biomarkers are used as prognostic and diagnostic markers of ards. some of them are characteristics of the different damages in the ards (alveolar epithelium and vascular endothelium lesions) : srage, sp-d, pai 1 and sicam 1. this study's hypothesis is that patients with ards criteria and lobar morphology on ct scan present loss of aeration but no inflammatory pulmonary oedema, whereas patients with non lobar morphology on ct scan present both characteristics. the primary purpose of our protocol is to show that the patients who respond to ards criteria and have a lobar morphology on ct scan do not have an elevation of the biomarkers specific to the pulmonary aggression of ards.

this multicentric prospective observational study will compare the level of different biomarkers specific to ards damages : the soluble form of the receptor for advanced glycation end products (srage), the surfactant protein d (sp-d), plasminogen activator inhibitor type 1 (pai-1) and soluble intercellular adhesion molecule-1 (sicam 1) in the two pulmonary morphologies of ards on ct scan : lobar and non lobar. patients under mechanical ventilation and with ards criteria for less than 24 hours(american-european consensus conference, 1994) will be enrolled. within 24 hours of enrolment, 10ml of blood sample will be collected and stored at -80°c. plasmatic biomarker concentrations will be determined through elisa method. within 48 hours of enrolment, patients will have a pulmonary ct scan without injection (end of expiration and zeep), a classical practice in this pathology. nine university hospitals will take part in this study.

Eligibility criteria:
inclusion criteria: * patients \> 18 years * patients within the first 24 hours after onset of ards according to the 1994 american-european consensus conference (aecc) * patients under mechanical ventilation exclusion criteria: * pregnancy * acute exacerbation of diabetes * dialysis for end-stage kidney disease * alzheimer's disease * amyloidosis * evolutive neoplastic lesion * chronic hepatic disease: type c hepatitis, non alcoholic cirrhosis and adenocarcinoma. * evolutive copd * patients enrolled in another study

Keywords: ards plasmatic biomarkers lung morphology mechanical ventilation ct scan
improving myoelectric prosthetic and orthotic limb control

Conditions: Hemiparesis

Summary: the purpose of this study is to improve control of myoelectrically-controlled advanced orthotic devices (an exoskeleton device that use the body's muscle signals to drive movements of a robotic brace) by using advanced predictive decode algorithms, and the use of high count (\> 8) surface electromyographic (semg) electrodes.

this study looks to improve control of myoelectrically-controlled advanced powered orthoses (orthoses that use the body's muscle signals to drive movements of a robotic exoskeleton) by using advanced predictive decode algorithms, and the use of high count (\> 8) surface electromyographic (semg) electrodes.

Eligibility criteria:
inclusion criteria: * first-ever ischemic or hemorrhagic stroke * chronic stroke (at least 6 months since onset) * chronic hemiparesis * functional range of motion for contralateral arm exclusion criteria: * individuals who are currently incarcerated
sleep quality after cesarean delivery

Conditions: Cesarean Section Complications; Sleep Disturbance; Perioperative Complication

Summary: surgery causes poor sleep quality for several reasons eg. increasing stress hormonal production, pain, starvation, and environmental procedure namely noise, light, and nursing procedures. poor sleep quality also brings numerous side effects including delirium, delayed recovery, and affect breastfeeding. we, therefore, aim to elucidate the incidence of poor sleep quality in parturients undergoing cesarean delivery in the early postoperative period and investigate the factors involving poor sleep conditions.

surgery causes poor sleep quality for several reasons eg. increasing stress hormonal production, pain, starvation, and environmental procedure namely noise, light, and nursing procedures. postoperative pain after cesarean delivery can be found as high as 70 percent in the first postoperative pain. also, the side effect of anesthetic may cause poor sleep quality such as itching, nausea, and vomiting. poor sleep quality brings numerous side effects including delirium, delayed recovery, and affect breastfeeding. the data on obstetric patients sleep quality in the early postoperative period is scarce. we, therefore, aim to elucidate the incidence of poor sleep quality in parturients undergoing cesarean delivery in the early postoperative period and investigate the factors involving poor sleep conditions.

Eligibility criteria:
inclusion criteria: * age \>,= 18 years, undergoing cesarean delivery * receive spinal anesthesia with local anesthetic drug and intrathecal morphine * understand thai exclusion criteria: * patients receive epidural block or nerve block * patients require conversion to general anesthesia with any reasons * patients require endotracheal intubation with any reasons * patients admit to intensive care unit in postoperative period * patients with the end of operation at the time 24.00-6.00 am

Keywords: cesarean delivery sleep quality perioperative complication
cognitive behavioral therapy for depression relapse prevention in children and adolescents

Conditions: Depression

Summary: this study will determine the effectiveness of cognitive behavioral therapy in preventing a relapse of depressive symptoms in children.

depression is a chronic and episodic condition that may have devastating effects on social and emotional functioning, particularly in the pediatric population. while approximately 90% of children eventually recover from an episode of depression, up to 40% of those children relapse within 1 to 2 years. data indicate that cognitive behavioral therapy (cbt) delivered after depressive symptoms subside can significantly reduce depression relapses in adults. however, there are no comparable studies in children or adolescents. this study will determine whether cbt is effective in reducing a relapse of depressive episodes in children and adolescents with major depression. this study comprises two phases. in phase 1, all participants will receive drug treatment for 12 weeks. participants who respond to the treatment will complete the study after 12 weeks. participants whose depression symptoms return after 12 weeks will be enrolled in phase 2. in phase 2, participants will be randomly assigned to either continue drug therapy alone or to receive drug therapy plus cbt for 6 months. the cbt will focus on teaching participants skills to manage depressed moods and to identify situations which might put them at risk for a relapse in depressive symptoms. self-report scales will be used to assess the depressive symptoms of participants who complete phases 1 and 2 at study entry and at the end of the study.

Eligibility criteria:
inclusion criteria: * diagnosis of nonpsychotic major depressive disorder at least 4 weeks prior to study entry * clinical global impression severity score of 4 or greater * children's depression rating scale score of 40 or greater * currently attending school * willing and able to use acceptable methods of contraception, if applicable * in good general health * parent or guardian willing to provide informed consent, if applicable exclusion criteria: * history of psychotic disorders * alcohol or substance abuse or dependence within 6 months prior to study entry * history of anorexia nervosa or bulimia * chronic medical illness requiring regular medication * current use of medication with psychotropic effects * first-degree relatives (e.g., mother, father, sister, brother) with bipolar i disorder * at risk for suicide * failure of a previous adequate treatment with fluoxetine (defined as at least 40 mg/day for 4 weeks) * iq less than 80 * pregnancy or breastfeeding

Keywords: child adolescent cbt drug therapy
effects of basic body awareness therapy on pain, sleep, disability and quality of life in chronic low back pain

Conditions: Chronic Low-back Pain

Summary: chronic low back pain is a common problem worldwide. in treatment, conservative methods usually are used. basic body awareness therapy is related to mindfulness-based therapies and meditation techniques. it is a method that has been used and found effective in some diseases affecting the musculoskeletal system. therefore, in this study, body awareness was applied in addition to conventional treatment in patients with chronic low back pain.

throughout a lifetime, chronic low back pain is a common problem that affects approximately 80% of people. among musculoskeletal system problems, it is one of the most commonly observed issues. there are various treatment methods available. the absence of evidence-based treatment guidelines negatively affects the choice of treatment to be applied. there are medical and conservative treatment options. these methods include acupuncture, transcutaneous electrical nerve stimulation, injection therapy, non-steroidal anti-inflammatory drugs, and lumbar supports. basic body awareness therapy is a physiotherapy treatment method that has been developed in the scandinavian countries over the course of the last two decades. this innovative approach focuses on enhancing body awareness and has gained recognition as an effective therapeutic technique in the field of physiotherapy. basic body awareness therapy has been applied as a secondary treatment method in various conditions such as fibromyalgia, neck pain, and ankylosing spondylitis, and has been found to be effective. it has yielded positive results when used in addition to conventional treatments for musculoskeletal problems, as demonstrated in the literature. this study aims to apply basic body awareness therapy to individuals with chronic low back pain, based on its effectiveness in musculoskeletal issues, and create a new treatment combination. twenty-eight patients were included in the study, and in addition to the standard treatment protocol, basic body awareness therapy exercises were administered.

Eligibility criteria:
inclusion criteria: * having low back pain for 3 months or more * being between the ages of 18-65 * not having received any back-related treatment before * volunteer to participate in the study exclusion criteria: * pregnancy * history of tumor / metastatic disease * history of spinal trauma, spinal cord injury * history of infection * presence of congenital deformity in the spine * history of previous spinal surgery * having a neurological disease (alzheimer's, amyotrophic lateral sclerosis, multiple sclerosis, parkinson's, stroke) * having musculoskeletal problems other than low back pain (rheumatoid arthritis, pathological fractures, avascular necrosis or osteonecrosis, severe osteoarthritis, spondylo-arthropathy) * patients who received a physiotherapy rehabilitation program in the last 6 months

Keywords: pain quality of life disability sleep body awareness
quantitative evaluation of muscle tone using elastic ultrasound

Conditions: Muscle Tone Increased; Ultrasonography

Summary: the test subjects were selected from patients with clinical manifestations in muscle tone and healthy volunteers. elbow flexor is the main target muscle. fifty patients and 50 healthy subjects were given three assessment methods to measure muscle tension: modified ashworth rating scale, elastic ultrasound technology and surface electromyography, and the data obtained by these three methods will be statistically analyzed and discussed.


Eligibility criteria:
inclusion criteria: * there are clinical manifestations of changes in muscle tension of the elbow flexor group; * subject's diagnosis is clear; * the degree of joint mobility meets the method of muscle tension assessment. exclusion criteria: * has serious diseases such as heart, lung, liver, kidney, etc., cardiac function grade is greater than grade i (nyha), has symptoms and signs or examination results such as respiratory failure; * history of muscle disorders; * recent (within 6 months) history of external injury, fracture or surgery of the limb; * are using drugs that affect muscle tone; * severe osteoporosis; * acute phase of inflammation * acute limb thrombosis of the subject; * pregnancy.
massive transfusion protocol with coagulation algorithm

Conditions: Bleeding

Summary: in 2008 at the university hospital zurich (usz) a massive transfusion protocol was introduced. based on laboratory diagnostics and point of care (poc) devices including rotem. goal of this retrospective study is to evaluate the influence of this algorithm on coagulation, use of blood products, coagulation factors and rotem evolution.

in 2008 at the usz a massive transfusion protocol was introduced. based on laboratory diagnostics and poc (point of care) devices including rotem. goal of this retrospective study is to evaluate the influence of this algorithm on coagulation, use of blood products, coagulation factors and rotem evolution over three years (2008-2010)

Eligibility criteria:
inclusion criteria: * massive transfusion exclusion criteria: * non
the efficacy and safety of qizhiweitong granule on patients with functional dyspepsia in a multi-center clinical study

Conditions: Functional Dyspepsia

Summary: the study aims to verify the efficacy and safety of qizhiweitong granule on chinese patients with functional dyspepsia diagnosed by the rome iii criteria. it includes two subtypes of functional dyspepsia, postprandial distress syndrome or abdominal pain syndrome.


Eligibility criteria:
inclusion criteria: 1. patient with written icf signed 2. patient with functional dyspepsia diagnosed by the rome iii criteria 3. age between 18y and 65y;male or female. 4. patient without gastric ulcers, erosive gastritis or other gastric organic diseases according to the endoscopy in the past one year in the hospital 5. patient without hepatobiliary and pancreatic diseases according to b-ultrasoundin the past one year in the hospital 6. patient with normal ecg (qt interval in the normal range) within one month prior to enrollment in this center 7. patient with symptoms of only one subtype of functional dyspepsia exclusion criteria: 1. history of abdominal surgery; 2. take drugs related to gastrointestinal motility or gastric acid secretion and gastric acid drugs, anti-helicobacter pylori drugs within 5 days of inclusion 3. suffering from hepatobiliary and pancreatic diseases with b ultrasound 4. suffering from high blood pressure and uncontroled hypertension 5. diabetes mellitus 6. have history of thyroid disease, systemic sclerosis, systemic lupus erythematosus 7. severe mental disorders 8. pregnant women, breastfeeding women or those who plan to become pregnant 9. allergy to qizhiweitong particle 10. have symptoms of both subtypes of functional dyspepsia
limits of stability in sitting in healthy controls and participants post stroke

Conditions: Stroke; Balance; Distorted

Summary: in this cross-sectional study we will compare the limits of stability in non-ambulatory participants post stroke compared to healthy controls. this will be done by placing participants in a seated position on a force platform, that will measure centre of pressure displacements during a leaning task in multiple directions. the results of the limits of stability test will be compared to standard clinical measures of trunk control and functional balance, to see if there is a relationship between both ways of measuring. and how balance and trunk control are affected in the subacute stroke population.


Eligibility criteria:
inclusion criteria participants post stroke: * a stroke with clear hemiplegia (a previous stroke is accepted when complete recovery was achieved) * being a patient at the uz pellenberg * functional ambulation catergory of two or less * to be able to sit independently for 2 minutes * to be cooperative enough to fulfill multiple evaluations and tests * to be able to understand simple instructions and be able to execute those. exclusion criteria participants post stroke: * to have musculoskeletal and/or other neurological disorders that could influence the protocol * severe communication, memory or language disorders that could disturb the understanding of the research protocol. * no signed informed consent inclusion criteria healthy controls: * age above 50 * to be able to stand independently for 2 minutes exclusion criteria healthy controls: * a disorder that could influence balance capabilities * berg balance scale less than 50 points * no signed informed consent
study of chemotherapy and patient health outcomes for nausea and emesis (0000-041)

Conditions: Chemotherapy Induced Nausea and Vomiting

Summary: the purpose of this study is to assess whether timely feedback to providers on patient experiences with delayed chemotherapy induced nausea and vomiting (cinv) lead to differences in patient outcomes for subsequent cycles.


Eligibility criteria:
inclusion criteria: * highly or moderately emetogenic chemotherapy planned for at least 2 cycles exclusion criteria: * concurrent other anti-cancer therapy (e.g. radiation, hormone, etc.); vomiting during the 24 hours prior to first chemotherapy cycle; having a disease/condition or taking medication that may cause emesis