Kornimate/medical-research-clean huggingface dataset:
clinical study of tripterygium capsule to treat early ankylosing spondylitis

Conditions: Early Ankylosing Spondylitis

Summary: this study is a 12-week, randomized, placebo and positive drug controlled clinical trial to investigate whether tripterygium capsule is effective and safe in treating patients with ankylosing spondylitis. the investigators expect that the tripterygium capsule is more effective than placebo and has few adverse effects.


Eligibility criteria:
inclusion criteria: 1. fulfill the essg criteria for spa and not fulfill any criteria for the subtype including ankylosing spondylitis, psoriatic arthritis, reactive arthritis and inflammatory bowel disease associated arthritis. 2. disease is in active status defined by basdai\>=40mm. 3. dmards administration must be suspended for at least 4 weeks before screening. nsaids dose must be stable for at least 4 weeks before screening. exclusion criteria: 1. intra-articular injection of glucocorticoid within 3 months. 2. previous history of heart failure, multiple sclerosis, chronic obstructive pulmonary disease, recurrent infection, lymphoma or other tumors. 3. accompanied by fibromyalgia syndrome or other rheumatic diseases. 4. female of pregnancy or breast-feeding. 5. poor compliance or with mental diseases.
taste test between desloratadine and cetirizine syrup in children (study p03826)

Conditions: Allergic Rhinitis

Summary: this study was conducted to compare the taste acceptability of zyrtec syrup with desloratadine syrup in children. children between 6 and 11 years of age received 5 ml of each syrup, separated by 15 to 20 minutes on a single day.

this study is a cross-over study design.

Eligibility criteria:
inclusion criteria: subjects must be: * between 6 and 11 years of age in good general health * premenarcheal if female exclusion criteria: subjects who: * have known allergies or sensitivities to either of the drug formulations * have a medical condition that may interfere with the subject's ability to discriminate between tastes * have used any antihistamines within 24 hours prior to dosing * were taking sedatives, tranquilizers, or monoamine oxidase inhibitor drugs * were involved in another clinical or market research study within the past 30 days
a study of cytokine and inflammatory markers in patients with chronic renal failure

Conditions: Chronic Renal Failure

Summary: we hope to study components within the blood that may predict success, failure or other associated complications in relation to the type of vascular access being used.

renal failure affects more than 350,000 patients in the united states. all patients undergoing dialysis must have access to the vascular system (blood stream) for hemodialysis treatment. methods of access include a catheter, or tube, that goes through the skin and into a large vein, a surgically created connection of a vein to an artery called an av fistula, or a surgically created connection of a vein to artery using a graft or plastic tube. previous research has shown considerable differences in the function and success in these types of vascular access for dialysis. research investigators try to explain these differences and find the causes and explanations for the variations seen in vascular access. forty patients undergoing dialysis treatment will be evaluated by analyzing serum specimens obtained during outpatient hemodialysis access. serum will also be collected from ten pre-dialysis patients and ten normal volunteers for comparison. pre-dialysis patients are those who have stage 3, 4, or 5 chronic kidney disease but are not yet on dialysis and have never had any type of created vascular access. normal subjects will have no kidney disease, autoimmune disorders, recent (\<6 months) chemotherapy treatment or corticosteroid use, or other chronic condition determined by the investigator to interfere with cytokine and inflammatory markers. the serum specimens will be analyzed for cytokine/inflammatory markers and correlated with clinical access type and other medical data and demographic information.

Eligibility criteria:
inclusion criteria: * male and female patients of dr. william jennings and dr. pranay kathuria undergoing dialysis therapy as outpatients * male and female patients of dr. pranay kathuria who have been diagnosed with stage 3, 4, or 5 chronic kidney disease, but who are not yet on dialysis. * healthy volunteers with no kidney disease, autoimmune disorders, recent (\<6 months) chemotherapy treatment or corticosteroid use, or other chronic condition determined by the investigator to interfere with cytokine and inflammatory markers. * 18 to 90 years of age exclusion criteria: * under 18 years of age * over 90 years of age * prisoners * institutionalized patients * pregnant individuals * patients with mental illness who are not able to give informed consent

Keywords: hemodialysis vascular access arteriovenous fistula indwelling percutaneous catheters arteriovenous grafts
adaptation of a knowledges exchange portal between (kep) healers and patients : obstacles and sources to kep use for breast cancer women

Conditions: Breast Cancer

Summary: the project is imbued with the whole problematic of patient follow-up and patient support, taking into account the experiences and needs of breast cancer patients. it concerns the dissemination of knowledge through the implementation of a specific clinical innovation designed to optimizing breast cancer patient pathway. the " patients en réseau " association offers us to participate at the web platform evolution mon réseau cancer du sein in adapting it. the feasibility study focuses on (1) the platform utilization and (2) sources and obstacles to its utilization in the french context

one of the french cancer plan 2014-2019 objectives is to improve the town-hospital coordination and information's exchange between professionals. this research project aims to reach this important objective of exchange development and the amelioration of the coordination concerning breast cancer women. breast cancer requires the integration of aggressive treatments implying physical, psychological and social consequences. that's why an optimized care pathway needs a coordinated and multidisciplinary organization, and more particularly a personalized approach taking into account the whole patients' needs in physical, psychological and social perspectives. to reach this goal, it is important to support those patients, to answer their needs for a better disease management in their own health pathways. the research issues lie in this outcome. the project is imbued with the whole problematic of patient follow-up and patient support, taking into account the experiences and needs of breast cancer patients. it concerns the dissemination of knowledge through the implementation of a specific clinical innovation designed to optimizing breast cancer patient pathway. the " patients en réseau " association offers us to participate at the web platform evolution mon réseau cancer du sein in adapting it. the feasibility study focuses on (1) the platform utilization and (2) sources and obstacles to its utilization in the french context

Eligibility criteria:
inclusion criteria of patients : * age ≥ 18 y.o; * with a diagnosis of breast cancer, * treated at the bergonié institute; * patients who express a non-opposition to participate to savaq research; * patients who have an internet access at home. inclusion criteria of healers : - doctors, nurse, senior health manager, technologist medical imaging from the center participated to the research exclusion criteria of patients: * patients with a severe psychiatric pathology (medical diagnosis); * patients who doesn't speak french
lung cancer screening in high-risk black women

Conditions: Lung Cancer; Lung Carcinoma

Summary: the goal of this research study is to study u.s. black women with a history of smoking to examine the feasibility, acceptability, and performance of low-dose computed tomography (ldct) screening among this population. the name of the intervention used in this research study is: low-dose computed tomography (radiologic scan) chest scan

the goal of this single-arm pilot research study is to evaluate the feasibility and acceptability of low-dose computed tomography (ldct) screening for lung cancer among u.s. black women with a history of smoking. ldct screening is currently the only recommended way to screen for lung cancer among high-risk individuals. however, the majority of black women at high-risk for lunch cancer are currently ineligible for lung cancer screening. study procedures include screening for eligibility, completion of questionnaires, and a ldct screening test. participation in this study is expected to last up to 3 months. it is expected about 900 people will participate in this study.

Eligibility criteria:
inclusion criteria: * self-identified black women. * have a self-reported history of smoking. no restriction will be placed on the number of smoking pack years participants must have nor the number of years former smokers must have quit smoking. * aged \>= 50 years. exclusion criteria: * individuals with a history of lung cancer. * individuals with symptoms suggestive of lung cancer. we will evaluate whether women have symptoms suggestive of lung cancer by administering an online screening questionnaire, which will ask whether they have experienced shortness of breath, whether they become easily winded, and whether they have had a chronic cough within the last 12 weeks that has not improved. women who select that they have any one of these symptoms will be advised to follow up with their primary doctor and will not be eligible to participate in the study. * individuals with pneumonia or acute respiratory infection within 12 weeks prior to enrollment that was treated with antibiotics.

Keywords: lung cancer lung carcinoma
evaluating an ehealth solution for screening in pediatric care

Conditions: Pain; Stress Disorders, Post-Traumatic

Summary: this study will evaluate the predictive validity of a game-based screening system based on child self-report measures. the core study hypotheses are that (1) in-game assessments will predict problematic recovery (child pain and posttraumatic stress symptoms \[ptss\]) and (2) parents in the intervention group will report greater confidence in managing child recovery.

this study will evaluate the predictive validity of a game-based screening system based on child self-report measures. the core study hypotheses are that (1) in-game assessments will predict problematic recovery (child pain and ptss) and (2) parents in the intervention group will report greater confidence in managing child recovery. study design: this study is a randomized controlled trial that will examine validity of escreen measures (primary aim) and assess the impact of the escreen system on parent confidence in managing child symptoms and recovery (secondary aim). at t1, after baseline assessment (questionnaires), children will be randomized to the usual care plus escreen (escreen) or usual care alone (usual care) groups. in the escreen group, children will use the game-based screening component and parents the parent information component for 6 weeks. all participants will complete follow-up research assessments by phone, online, or mail at t2 (6 weeks) and t3 (12 weeks). following their t3 research assessment, child participants in the usual care group will have the option to play and provide feedback on the game (with no in-game assessment and no parent information component).

Eligibility criteria:
inclusion criteria: * child treated or admitted for injury or illness event that occurred within the past month * child has regular access to a compatible (ios or android) tablet at home * parent has an internet-capable smartphone and can receive text messages on that phone, or has email account that can receive messages about child status * child and parent read or understand english well enough to consent / assent to participation and complete study tasks (e.g., checklists, use of screening system) exclusion criteria: * index medical event is due to family violence
femoral or sciatic nerve block to provide analgesia after proximal tibial osteotomy

Conditions: Postoperative Pain

Summary: proximal tibial osteotomy is associated with moderate to severe postoperative pain. the proximal part of the tibia is innervated by branches from the femoral nerve anteriorly and the sciatic nerve posteriorly. little is known on the type of peripheral nerve block to perform so that optimal postoperative analgesia is provided with minimum impact on the motor function. this randomised controlled double-blinded trial tested the hypothesis that a femoral nerve block provides superior analgesia than a sciatic nerve block after proximal tibial osteotomy.


Eligibility criteria:
inclusion criteria: * proximal tibial osteotomy exclusion criteria: * femoral or sciatic nerve deficit, * pre-existing peripheral neuropathy, * chronic pain diagnosis, * pregnancy, * identified contraindications to peripheral nerve block (e.g., local anesthetic allergy, coagulopathy, or infection at the block site).
early administration of long-acting insulin treatment of diabetic ketoacidosis in pediatric type 1 diabetes

Conditions: Diabetes Mellitus, Type 1; Diabetic Ketoacidosis

Summary: the management goals of diabetic ketoacidosis (dka) in the pediatric type 1 diabetes (t1dm) population are fluid and electrolyte repletion, insulin administration, and correction of acidosis in order to stabilize the patient. traditionally, a rapid-acting insulin iv infusion is begun immediately and continued until the acidosis is corrected and hyperglycemia normalized. once the acidosis is corrected, patients are able to be transitioned to a subcutaneous insulin regimen. the role that a subcutaneous long-acting insulin such as glargine has in the acute treatment of dka has not been extensively studied. while giving glargine during the treatment of dka is becoming more common place, few studies have examined the potential risks and benefits of its use. this study will investigate the effects of early administration of glargine during dka in patients with newly diagnosed tidm. the design of this study is a prospective, double-blind study of children ages 2-21 who are admitted to the hospital in dka with a diagnosis of t1dm. the control group will receive all traditional methods of treatment for dka, including a placebo subcutaneous injection. the study group will receive the same treatment, but will be supplemented with a subcutaneous glargine injection.


Eligibility criteria:
inclusion criteria: * t1dm * hyperglycemia \>200 mg/dl * bicarbonate ≤ 15 mmol/l * ph \< 7.3 * ketonemia * ketonuria * glucosuria * admission to picu (pediatric intensive care unit) * ages 1-21 years exclusion criteria: * patients who received glargine within the last 24 hours * patients with sepsis
enhancing hiv risk reduction among indian women with risky husbands

Conditions: Behavioral Risk for HIV

Summary: this grant involved the development, implementation, and assessment of the feasibility and acceptability of an hiv prevention intervention for at-risk wives in mumbai, rhani wives (raising hiv awareness among non-infected indian wives). the rhani wives intervention was adapted from the hiv intervention program (hiv-ip), a community-based, multi-session hiv intervention with demonstrated effectiveness among latinas whose primary risk for hiv was from their primary male partner (raj et al. 2001). specific aims of this study are as follows: 1. to adapt hiv-ip, a culture and gender-tailored hiv intervention for latinas with demonstrated effectiveness in reducing risk for hiv, and to create rhani wives for use with at-risk indian wives. 2. to determine the feasibility and acceptability of rhani wives with at risk wives\* in india. a two-group cluster randomized trial will involve random assignment of 12 neighborhood clusters (25 women/cluster) to receive the intervention (n=150) or a control condition (n=150). intervention effects on the more proximal and likely safer sex mediating outcome of marital communication for this feasibility trial will be assessed via surveys at baseline and 3 month follow-up. note: only 220 participants were able to be recruited into the study. \*at risk wives are defined as having a husband at higher risk for transactional sex based on wife's reports of his risky alcohol use (drunk in past 30 days, 3+ drinking days in past 7 days) or partner violence perpetration


Eligibility criteria:
inclusion criteria: 1. married female aged 18-40 years 2. fluency in hindi or marathi 3. residence with husband in the area of study for a period of 2 months or greater 4. reports that husband engaged in either heavy drinking- past 30 day drunken behavior, or frequent drinking- 3 drinking days in past 7 days, or lifetime spousal violence perpetration 5. no plans to relocate from the area in the next year. exclusion criteria: * cognitive impairment indicated at recruitment

Keywords: hiv condom use india women
cardiac function and cardiovascular risk profile in testicular cancer patients

Conditions: Testicular Cancer; Seminoma; Non-seminomatous

Summary: for many years, researchers and doctors have studied different kinds of treatments to improve the survival of men with testicular cancer. however, recent research has shown that many years later, men who had testicular cancer appear to be at higher risk for developing heart disease (heart attack or heart failure), especially if they received chemotherapy. since these studies were done many years after men received treatment, there was no way to know if other factors contributed to the health problems they experienced. this study is being done because it would be helpful to study heart function and cardiovascular disease risk factors of men who have been diagnosed with testicular cancer, before and after they receive chemotherapy treatment compared to men who receive treatment with surgery alone.

the aim of this pilot study is to examine global and regional lv systolic and diastolic function, cardiac output, cardiac reserve, vo2peak and cvd risk profile in males recently diagnosed with testicular cancer treated with surgery alone or surgery and chemotherapy.

Eligibility criteria:
inclusion criteria: * surgery and surveillance * surgery and multi-cycle chemotherapy * both good and intermediate prognosis seminoma and non-seminomatous germ cell testicular tumors * karnofsky performance index \> 70% * no contraindications to cardiopulmonary testing exclusion criteria: * documented cardiovascular disease or evidence of myocardial ischemia on the incremental exercise (vo2peak) test.

Keywords: cardiovascular risk factors cardiac function vo2peak chemotherapy
whole-body 18f-fdg pet in induction chemotherapeutic response for advanced npc patients

Conditions: Nasopharyngeal Cancer

Summary: 18f-fdg pet, a whole-body imaging technology based on glucose metabolism, can effectively detect subclinical and clinical therapeutic responses at stages that are earlier than those detected by conventional approaches. we propose to conduct a prospective study to evaluate therapeutic response using 18f-fdg pet before and after induction chemotherapy for locally advanced npc patients.

in order to improve locoregional control and to eradicate micrometastases for patients with locally advanced nasopharyngeal carcinoma (npc), induction chemotherapy followed by concurrent chemoradiotherapy has been the preferred therapeutic approach.although it would be of great advantage to identify non-responder during or immediately after therapy to formulate an alternative treatment strategy, non-invasive methods for early evaluation of therapeutic response for advanced npc patients have not been fully evaluated. decrease of tumor volume in anatomical images and relief of symptoms in clinical follow-up have been used in many conventional approaches to evaluate the effectiveness of therapy. however, an effective therapy could very well have resulted in early subclinical alterations in tumor physiology and biochemistry. these alterations may have occurred long before changes in the tumor mass become apparent. thus therapeutic effect may not be assessed accurately using the conventional anatomical imaging studies, such as ct and mri.recent studies have shown that 18f-fdg pet, a whole-body imaging technology based on glucose metabolism, can effectively detect subclinical and clinical therapeutic responses at stages that are earlier than those detected by conventional approaches.we therefore propose to conduct a prospective study to evaluate therapeutic response using 18f-fdg pet before and after induction chemotherapy for locally advanced npc patients.

Eligibility criteria:
inclusion criteria: * newly diagnosed locally advanced npc patients who are receiving induction chemotherapy for treatment exclusion criteria: * age below 18 year old * pregnancy women

Keywords: npc induction chemotherapy therapeutic response 18f-fdg pet
mgus, smm, and mm patient experience with coronavirus 19 (covid-19) survey

Conditions: Multiple Myeloma; Smoldering Multiple Myeloma; Monoclonal Gammopathy of Undetermined Significance; Coronavirus

Summary: the purpose of this study is to examine how patients with multiple myeloma (mm) have been impacted by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) pandemic. the study will use a questionnaire to further understand how patients are being affected and gather information in order to track the long-term effects of the coronavirus. the scope of the questionnaire will include, covid-19 diagnosis and treatment, changes in myeloma treatment and care, clinical trial familiarity, health and fitness, and quality of life. this questionnaire is a follow-on to the "mm and covid-19" questionnaire.


Eligibility criteria:
inclusion criteria: * adult patients (greater than 18 years) diagnosed with mgus, smoldering myeloma, and multiple myeloma. * access to a computer or electronic device with internet access, or phone * willing to create a patient profile on the healthtree cure hub for multiple myeloma * willing to give electronically-signed consent * ability to read questions in english

Keywords: questionnaire