Kornimate/medical-research-clean huggingface dataset:
serologic surveillance for sars-cov-2 (covid-19) in a prospective cohort of health care workers

Conditions: COVID-19; SARS-CoV 2; Health Personnel

Summary: the investigators will follow a single prospective cohort of 50 health care workers in the hospital italiano de buenos aires (argentina) from may 15th to august 31st 2020 using antibody testing for sars-cov-2 igm and igg at baseline and every 2 weeks in order to assess the incidence of covid-19, the prevalence of anti-sars-cov-2 antibodies (igm and igg) and incidence of reinfection or reactivations of previous covid-19 using viral gene sequencing in this cohort.

sars-cov-2 infection in healthcare workers (hcw) is nowadays a frequent problem for patient care and organization of care teams. sars-cov-2 antibody assessment provides a tool to evaluate antibody prevalence in hospital staff identifying previously exposed individuals. serologic testing could identify new cases of covid-19 in an early fashion and could help to investigate cases of reactivation or reinfection in hospital workers. the study purpose is to conduct a study using serological screening for health care workers in a university hospital in buenos aires in order to assess the risk of covid-19 on those who have not developed an immune response against the virus, or to detect it in an early fashion (either pre-symptomatic or asymptomatic). if a study participant is suspected to have potential reinfection or reactivation of covid-19, the investigators will conduct genome sequencing in order to be able to differentiate each case. the investigators will include 50 participants chosen at random among health care workers from the hospital emergency department (ed), internal medicine wards, or critical care units who are exposed to covid-19. participants who agree to join the study and sign the informed consent form will be screened at baseline for sars-cov-2 igm and igg antibodies, along with a physical exam and basic laboratory determinations. they will be re-screened with antibodies every 2 weeks for a total of 3 months. if they contract covid-19, antibody determinations and nasopharyngeal swabs will be carried out in order to identify those who are in favorable conditions to return to work. the main objective is to prospectively determine the incidence of covid-19, anti sars-cov-2 antibody prevalence, and incidence of sars-cov-2 reinfection or reactivation of covid-19 in a health care workers cohort.

Eligibility criteria:
inclusion criteria: 1. healthcare staff (physicians) and 2. directly involved in care of patients with confirmed or suspected covid-19 and 3. working in any of the two hospital venues (hospital italiano central and hospital italiano san justo agustín rocca). exclusion criteria: 1. refusal to sign the informed consent form or 2. experienced symptoms compatible with covid-19 in the last 14 days prior to eligibility screening

Keywords: sars virus sars-cov-2 covid-19 health personnel
expectations, satisfaction and quality of life in total hip arthroplasty

Conditions: Hip Osteoarthritis; Arthroplasty, Replacement, Hip

Summary: the goals of this study are to identify predictors of improvement in quality of life and satisfaction with total hip arthroplasty three to five years after surgery.

the goals of this study are to identify predictors of improvement in quality of life and satisfaction with total hip arthroplasty three to five years after surgery. predictors that will be considered are variables that were obtained prospectively and systematically at the time of surgery, including demographic characteristics, functional status, expectations, perioperative complications, and comorbidity. at the follow-up functional status and patient satisfaction will be measured, as well as fulfillment of expectations and predispositional factors.

Eligibility criteria:
inclusion criteria: * patients will be eligible for this study if they are part of an assembled cohort of patients who underwent primary unilateral or bilateral total hip arthroplasty in 1998-2000 at the hospital for special surgery. exclusion criteria: * patients will be excluded if they are unable to be interviewed, refuse to participate, or are deceased.

Keywords: total hip arthroplasty expectations satisfaction quality of life
stroke ready - optimizing acute stroke care

Conditions: Stroke, Acute; Stroke

Summary: the study aims to increase acute stroke treatment rates in flint, michigan through a two-pronged approach of hospital and community level interventions. it also aims to inform future stroke preparedness interventions by exploring the relative importance of hospital optimization and community interventions.


Eligibility criteria:
inclusion criteria:adult stroke patients who presented to one of three hospitals in the flint community.
changes in oral vitamin k intake for optimization of chronic oral anticoagulation: a randomized trial

Conditions: Blood Coagulation Disorders

Summary: the primary hypothesis of this trial is that changes in oral vitamin k intake, based on simple food registries, may be superior to conventional changes in doses of medications in order to stabilize chronic oral anticoagulation.


Eligibility criteria:
inclusion criteria: * patients with any clinical indication for chronic oral anticoagulation with one inr level out of target, without a clear clinical cause for inr instability (unplanned changes in coumadin medications, other pharmacological interactions, clinical illnesses and laboratory errors). exclusion criteria: * clinical evidence of bleeding or thrombosis. * inr \> 4 or inr \< 1,5.

Keywords: chronic oral anticoagulation
act-128800 in patients with moderate to severe chronic plaque psoriasis

Conditions: Psoriasis

Summary: this study will assess the efficacy, safety and tolerability of two doses of act 128800 in patients with moderate-to-severe chronic plaque psoriasis.


Eligibility criteria:
inclusion criteria: * adult males and females aged 18 to 60 years (inclusive) with moderate to severe chronic plaque psoriasis who require systemic treatment. exclusion criteria: * patients with other forms of psoriasis and patients who are currently treated for autoimmune disorders other than psoriasis. * systemic or topical treatments for psoriasis other than emollients. ongoing bacterial, viral or fungal infections. history or presence of malignancy. * additional inclusion and exclusion criteria apply with respect to medical conditions and concomitant treatments which could affect patients' risk from participating in the study.

Keywords: psoriasis chronic plaque psoriasis moderate to severe chronic plaque psoriasis
diagnostic performance of a convolutional neural network for diminutive colorectal polyp recognition

Conditions: Artificial Intelligence; Colorectal Polyp

Summary: rationale: diminutive colorectal polyps (1-5mm in size) have a high prevalence and very low risk of harbouring cancer. current practice is to send all these polyps for histopathological assessment by the pathologist. if an endoscopist would be able to correctly predict the histology of these diminutive polyps during colonoscopy, histopathological examination could be omitted and practise could become more time- and cost-effective. studies have shown that prediction of histology by the endoscopist remains dependent on training and experience and varies greatly between endoscopists, even after systematic training. computer aided diagnosis (cad) based on convolutional neural networks (cnn) may facilitate endoscopists in diminutive polyp differentiation. up to date, studies comparing the diagnostic performance of cad-cnn to a group of endoscopists performing optical diagnosis during real-time colonoscopy are lacking. objective: to develop a cad-cnn system that is able to differentiate diminutive polyps during colonoscopy with high accuracy and to compare the performance of this system to a group of endoscopist performing optical diagnosis, with the histopathology as the gold standard. study design: multicentre, prospective, observational trial. study population: consecutive patients who undergo screening colonoscopy (phase 2) main study parameters/endpoints: the accuracy of optical diagnosis of diminutive colorectal polyps (1-5mm) by cad-cnn system compared with the accuracy of the endoscopists. histopathology is used as the gold standard.


Eligibility criteria:
phase 1a - - patients with one polyp subtype (based on histology) phase 1b patients older than 18 years that underwent colonoscopy in one of the participating centres. phase 2:- validation cad-cnn system inclusion criteria: all patients older than 18 years old undergoing screenings colonoscopy in one of the participating centres. exclusion criteria: * diagnosis of inflammatory bowel disease, lynch syndrome or (serrated) polyposis syndrome. * boston bowel preparation scale (bbps) \<2 in one of the colon segments * patients who are unwilling or unable to give informed consent

Keywords: artificial intelligence computer aided diagnosis diminutive colorectal polyps optical diagnosis
a placebo-controlled study of levetiracetam in children (1mo to 4yrs of age) with partial onset seizures.

Conditions: Epilepsy, Partial

Summary: to evaluate the safety and efficacy of levetiracetam used as adjunctive treatment in pediatric subjects age 1 month to less than 4 years with partial onset seizures. subjects will be evaluated with 48 hour inpatient video electroencephalograms (a selection and an evaluation). other neuropsychological clinical assessments will be performed during the 34 day length of the study.


Eligibility criteria:
inclusion criteria: * pediatric patients from 1 month to less than 4 years of age * pediatric patients diagnosed with refractory partial onset seizures, on a stable regimen of one to two other anti-epileptic drugs and at least 2 partial onset seizures per week in the two weeks prior to screening * patients must have two partial onset seizures (with corresponding clinical event) during the 48-hour video eeg at screening exclusion criteria: * a ketogenic diet * previous exposure to levetiracetam * seizures too close together to count accurately * treatable seizure etiology * current diagnosis of lennox-gastaut syndrome or epilepsy secondary to a progressing cerebral disease * diagnosis of a terminal illness

Keywords: partial onset seizure levetiracetam video electroencephalogram keppra
apidra registration study

Conditions: Diabetes Mellitus, Type 1

Summary: to collect effectiveness and safety data during the treatment with apidra glulisine (hmr1964) by means of subcutaneous injections to patients with diabetes mellitus 1st type during 12 weeks-active phase.


Eligibility criteria:
inclusion criteria: * diabetes mellitus 1st type, with нba1c level in the range of ≥ 6,5 - \<=11%, receiving the regimen of multiple injections of insulin during one year. exclusion criteria: * active proliferative diabetic retinopathy connected with focal or panretinal photocoagulation or vitrectomy carried out within 6 months before visit 1, or any unstable (quickly progressive) form of retinopathy, which may need in surgical intervention (including laser photocoagulation) during study * diabetes mellitus of the 2nd type * patients transmitted pancreatectomy * patients transmitted transplantation of pancreas or islet cells * probable therapy by means of products not approved by study minutes during the study * anamnestic indications of convulsive disorders * allergic reaction on insulin or any filler of preparation apidra (glulisine) * clinical serious diseases of cardiovascular system, liver, nervous system, endocrine system, oncologic diseases or other serious system diseases, which complicate keeping of minutes or interpretation of study results, and, at the investigator's opinion, impede the safe participation of patients in study * drug addiction or alcoholism * disturbance of liver functions confirmed with the increase of alt or ast activity up to the level twice as high as the upper standard limit (these indications may not be single) * disturbance of functions of kidneys confirmed with the level of creatinine in serum that is more than 177 mµmol/l at visit 1 (this indication may not be single) * pregnancy or breast-feeding the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
end tidal anesthetic concentration in different anesthesia techniques where depth of anesthesia adjusted with entropy

Conditions: General Anesthesia; Inhalation; Gas

Summary: the aim of this study is to adjust the end tidal inhalation anesthetic concentration by observing the entropy value in patients who will be provided anesthesia maintenance with volatile anesthetics after applying the routine epidural anesthesia technique and to observe the end tidal volatile concentration that will provide to remain in the target entropy limits during the operation.

the hypothesis of this study is that in general anesthesia cases which is combined with thoracic epidural anesthesia (tea), lower alveolar concentration will be required to reach the same anesthesia depth. the main aim of the study is observing and comparing the alveolar concentrations of anesthetic agents with entropy monitoring which is an anesthesia depth monitor in major abdominal surgeries where general anesthesia is combined or not with tea. in cases where tea is combined with general anesthesia or not, anesthesia depth will be effectively monitored by entropy monitoring, in this way the adequate depth of anesthesia will be provided with the use of minimal volatile anesthetics and we will be able to prevent the use of large amounts of volatile anesthetics., it will be determined how much reduction in alveolar concentration is required in cases combined with tea. nowadays, with the development of reliable anesthesia machines, "low-flow anesthesia" (lfa) is becoming more widespread, and its benefits on patient health, economy and ecology have been demonstrated. in lfa, the depth of anesthesia should not be too superficial or too deep during the time the alveolar concentration of volatile agent reaches equilibrium. therefore, alveolar concentrations of volatile anesthetics are monitored in modern anesthesia machines. some machines may also adjust the depth of anesthesia according to the alveolar concentration of the agent.

Eligibility criteria:
inclusion criteria: * undergoing major abdominal surgery * patients who will not undergoing operation for thoracic cavity * body mass index (bmi) between 20-30 exclusion criteria: * denial of patients * contraindications for thoracic epidural anesthesia * patients who are fev1/fvc \< 60 * patients with thoracic and lomber vertebrae surgery

Keywords: minumum alveoler concentration entropy monitorining general anesthesia general anesthesia combined with tea
real-time telehealth to promote self-care management for chronic obstructive pulmonary disease

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: hypothesis:the study purpose is to evaluate the effectiveness of a structured pursed-lips breathing (plb) protocol taught via real-time interactive telecommunication with a home computer using the lnternet and skype software in veterans with chronic obstructive pulmonary disease (copd. the primary hypothesis is veterans with copd and dyspnea on exertion who receive a plb educational intervention taught via weekly interactive telecommunication over a 4-week period will have greater reduction of exertional dyspnea compared to those who receive the plb educational intervention with no weekly interactive sessions. research plan: an experimental two- group design is used. all subjects receive a brief 5 - 10 minute one-on-one plb educational session. subjects are then randomized to either the intervention group or the control group. the intervention group receives 4 weekly interactive group sessions with the health educator (principal investigator)via computer. a free software program known as skype allows synchronous video and audio interaction. the comparison group receives only the brief plb educational session with no weekly follow-up. results: at end of 4 weeks, the intervention group had significantly lower dyspnea intensity scores (group x time interaction f = 6.69, p = 0.02) and significantly higher social support scores (group x time interaction f = 4.34, p = 0.058). clinical significance: skype is a viable means for providing patient education. a structured plb protocol provides significant differences in exertional dyspnea over time. a structured plb protocol plus skype showed significant reduction in patients' sense of dyspnea intensity and increased social support scores.


Eligibility criteria:
inclusion criteria: clinical diagnosis of copd, expiratory airflow limitation evidenced by forced expiratory volume 1 second/forced vital capacity percent (fev1/fvc %) less than 70 and fev1 % predicted less than 80 with no reversibility by inhaled bronchodilator, and self report of shortness of breath when walking as assessed with the modified medical research council (mrc) chronic dyspnea questionnaire. - exclusion criteria: exacerbation of symptoms (dyspnea, increased sputum volume, and/or increased sputum purulence) within the past four weeks, hospital admission within the past four weeks, change in bronchodilator therapy within the past two weeks, unable to walk, unstable angina, unstable cardiac dysrhythmia, unstable congestive heart failure, and/or unstable neurosis or psychiatric disturbance. -

Keywords: telemedicine internet dyspnea self care breathing exercises real-time systems
observational study to assess protection to mumps in children received one-dose mumps-containing vaccine

Conditions: Parotid Gland Infection; Fever

Summary: this study was aimed to conduct a 3-year perspective study to observe the immunological effect of one-dose mumps-containing vaccine, monitor the incidence of mumps in vaccinated population aged 3-7 years，and provide basis for adjusting mmr immunization strategy in jiangsu province, china.

in 3-7 years old children with high risk of mumps, epidemiological investigation of the serum igg antibody level were conducted, and then a prospective observational cohort was established in the population with a history of mumps vaccination, and the incidence of mumps in each antibody level group will be observed, the relationship between different antibody levels and the incidence after mumps vaccinated were analyzed, to explore attenuation of mumps igg antibody levels in the body,s79 vaccine strain against f genotype mumps' antigenic cross-reactivity and the protective effect of antibodies.

Eligibility criteria:
inclusion criteria: 1. children aged 3-7 years old; 2. local resident children living at least 3 months; 3. physical health, has been vaccinated at least once a dose of muv exclusion criteria: 1. did not administer muv; 2. refused to collect venous blood; 3. have been infected with mumps; 4. have serious illness or other reasons should not participate in the study after clinical evaluation

Keywords: mumps immunity cohort study children vaccine
effect of vestibular rehabilitation on trunk kinetic and kinematic parameters in patients with multiple sclerosis

Conditions: Vestibular Rehabilitation in MS

Summary: the cawthorne cooksey exercises and conventional program of physical therapy were administered.

• the cawthorne cooksey exercises and conventional program of physical therapy were administered.

Eligibility criteria:
inclusion criteria: * aged 35-55 years. * ambulatory without assistance. * diagnosed with relapsing-remitting ms by a neurologist, with approximately five relapse attacks in the hemiparesis type with a muscular tone of 1 or 1+ depending on the mas, or modified ashworth scale. * all individuals were evaluated by a neurosurgeon to confirm central vertigo using test of dix hallpike. * degree of ms-related disability based on the enlarged disability status scale, ranging from 2-2.5. exclusion criteria: * people with musculoskeletal deformities. * people with inner ear abnormalities. * people with psychiatric disturbances or seizures.

Keywords: trunk kinetic and kinematic parameters, vestibular rehabilitation, multiple sclerosis.
combination therapy with myo-inositol and folic acid versus myo-inositol alone

Conditions: Polycystic Ovary Syndrome; Hirsutism; Menstrual Irregularity

Summary: previous studies have demonstrated that myo-inositol is capable of restoring spontaneous ovarian activity, and consequently fertility, in most patients with pcos. the aim of our study is to investigate the role of folic acid conteined in the inositol preparation. the study group included 50 patients, randomly allocated to subgroup a (myo-inositol 1500 gr) and subgroup b (myo-inositol 2000 gr + folic acid 200 mcg). the investigation include menstrual pattern and hirsutism score evaluation, hormonal assays, oral glucose tolerance test, euglycemic hyperinsulinaemic clamp and lipide profile at baseline and after six months of treatment.


Eligibility criteria:
inclusion criteria: * women with pcos diagnosed in accordance with rotterdam consensus conference criteria 2003 * bmi \> 25 kg/m2 * age 18-35 years exclusion criteria: * pregnancy * significant liver or renal impairment * other hormonal dysfunctions (hypothalamic, pituitary, thyroidal or adrenal causes for the clinical signs) * neoplasms * unstable mental illness * diagnosis of diabetes mellitus or impaired glucose tolerance * use of drugs able to interfere with gluco-insulinaemic metabolism for at least three months prior entering the study.

Keywords: myo-inositol folic acid
the impact of early palliative care on the survival of locally advanced and / or metastatic cholangiocarcinoma patients

Conditions: Cholangiocarcinoma

Summary: the prognosis for cholangiocarcinoma is bad. potentially, early management by a palliative care team could increase overall survival. we will also assess whether early management by a palliative care team could impact progression-free survival, the place of death and the date of the last chemotherapy, in particular to avoid unnecessary chemotherapy cures in an imminent end of life


Eligibility criteria:
inclusion criteria: * age\> 18 years old * intra- or extra-hepatic cck or histologically proven vesicular adenocarcinoma * locally advanced and / or metastatic disease from the start or recurrent * initial diagnosis or recurrence between 1/01/2013 and 31/12/2019 exclusion criteria: * \<18 years old * death less than one week after the diagnostic