Kornimate/medical-research-clean huggingface dataset:
implementation of a habit-ile intervention at william lennox neurological hospital (neureha) - adult

Conditions: Stroke

Summary: using a randomized controlled trial design, in an hospital environment, possible changes induced by the "hand-arm bimanual intensive therapy including lower extremities (habit-ile)" treatment program will be investigated in functional activities of daily living, motor and cognitive assessment of patients with sub-acute post-stroke

the aim is to investigate, for the first time, the effectiveness of habit-ile therapy in a hospital setting in the treatment of a population representative of the clinical population for adult patients with subacute stroke. the hypothesis is that an in-hospital habit-ile protocol will be more effective than conventional therapies usually given to patients with sub-acute post-stroke, and that this difference will be objectively demonstrated by clinical assessments of motor function, cognition and participation conducted before and after treatment periods. the aim of the study is therefore to evaluate the effect of intensive bimanual hand-arm therapy including the lower extremities (habit-ile) on body functions and structures, activity and participation in adulte patients suffering from subacute stroke..

Eligibility criteria:
inclusion criteria: * phase aiguë ou subaiguë exclusion criteria: * epilepsie instable * absence à déterminer sa volonté à participer * traitement toxine pendant le stage

Keywords: stroke, intensive intervention, motor skill learning, subacute
cholinergic nicotinic receptors and cognition in pd

Conditions: Parkinson's Disease

Summary: mild cognitive impairment and dementia are frequent non-motor complications of moderate to advanced parkinson's disease. brain positron emission tomography (pet) study findings confirm post-mortem evidence that cholinergic loss is related to cognitive impairment in parkinson's disease. however, current cholinergic augmentation therapy is not always effective and it should only target those parkinson's disease patients who have evidence of cholinergic system impairment. the objective of this study is to study the association of a particular subtype of cholinergic receptors, so-called nicotinic acetylcholine receptors, with cognition in parkinson's disease using a novel pet marker of cholinergic system integrity.

parkinson's disease patients will undergo nicotinic acetylcholine receptor pet imaging with the radioligand \[18f\]flubatine and mri on one day and extensive neuropsychological testing on another day. the degree of nicotinic receptor expression obtained with pet imaging will be correlated with the neuropsychology test results. positive \[18f\]flubatine pet findings in this study would establish nicotinic receptors as an important contributor to cognitive dysfunction in parkinson's disease and could kindle pharmaceutical interest in pursuing these agents for parkinson's disease applications. we expect that lower nicotinic receptor expression is associated with impaired cognitive functioning in parkinson's disease. in a personalized medicine approach the pet radioligand \[18f\]flubatine could serve as an important marker to identify those patients who are expected to benefit most from nicotinic receptor drug treatment.

Eligibility criteria:
inclusion criteria: * pd subjects (m/f, non-smoking, ≥ 50 years old, hoehn \& yahr stages 1-4) * normal control subjects (n=15, m/f, non-smoking, ≥ 50 years old) exclusion criteria: * active smoking, use of other tobacco products, or use of nicotinic drugs such as nicotine patches or varenicline. * subjects with contra-indications to mr imaging, including pacemakers or claustrophobia. * evidence of large vessel stroke or mass lesion on mri. * use of (anti-)cholinergic or neuroleptic drugs. * dementia or severe cognitive impairment confirmed by clinical and detailed neuropsychological assessment precluding safe study participation, performing study procedures, or unable to follow directions by study personnel. * evidence of atypical parkinsonism on neurological exam. * subjects limited by participation in research procedures involving ionizing radiation. * pregnancy (test within 48 hours of each pet session) or breastfeeding

Keywords: cognition cholinergic nicotinic receptors positron emission tomography
prognostic impact of nlr, plr, and mpv in patients undergoing aaa open repair

Conditions: Abdominal Aortic Aneurysm

Summary: abdominal aortic aneurysm (aaa) is a multifactorial degenerative disorder, which if untreated might lead to catastrophic complications. the treatment for aaa includes open and endovascular repair, both of which carry a significant degree of risk. thus, researchers have performed several studies addressing simple and readily available risk stratification markers, such as complete blood count in patients undergoing open aaa repair. the neutrophil to lymphocyte ratio (nlr) has been frequently used as a marker of systemic inflammatory response, which reflects neutrophilia and lymphopenia. the primary pathophysiology of aaa involves chronic inflammation in the aortic wall and atherosclerosis, accompanied with thrombosis. nlr was proposed as a fair indicator for poor prognosis in patients with aaa. the mean platelet volume (mpv) is the marker of platelet activation and an indicator of the activation of thrombus formation. moreover, it is reportedly associated with the prognosis of patients with cardiovascular diseases. moreover, the platelet to lymphocyte ratio (plr) suggests thrombosis and inflammation and indicates a high risk of cardiovascular events in various groups of patients. the plr is associated with poor prognosis following aaa repair. despite accumulating evidence for the prognostic value of white blood cell counts in abdominal aortic aneurysm, few studies have investigated the value of these parameters, including nlr, mpv, and plr, in patients undergoing aaa open repair. the investigators aimed to investigate if preoperative neutrophil to lymphocyte ratio (nlr), platelet to lymphocyte ratio (plr), or mean platelet volume (mpv) could be used to predict 1-year mortality in patients undergoing open abdominal aortic aneurysm (aaa) repair.

the investigators will retrospectively review medical records who underwent open abdominal aortic aneurysm repair between jan 2008 and july 2019. the investigators will divide the patients into two groups according to the occurrence of 1-yr mortality. then the investigators compare complete blood count including nlr, plr and mpv between the groups. furthermore, the patient will be divided into tertiles according to the preoperative nlr, plr, and mpv values to compare the incidence of 1-yr mortality and other morbidities. multivariable logistic regression analysis will be performed to investigate possible prognostic factor for 1-yr mortality in these patients.

Eligibility criteria:
inclusion criteria: * patients who underwent open repair of abdominal aortic aneurysm. exclusion criteria: * patients with previous aortic repair within 6 months. * mycotic aneurysm. * iliac artery aneurysm. * aorta occlusive disease. * incomplete data.

Keywords: neutrophil to lymphocyte ratio platelet to lymphocyte ratio mean platelet volume aortic surgery abdominal aortic aneurysm.
a trial of radial ebus versus vbn for the peripheral pulmonary lesions

Conditions: Lung Cancer; Tuberculosis; Pneumonia

Summary: peripheral pulmonary lesions are of growing importance in respiratory field. early detection of lung cancer, tuberculosis and other diseases often needs a bronchoscopic investigation with different types of navigation. current randomized clinical study is intended to compare three different modalities of navigation in bronchial tree - virtual bronchoscopy (vbn), radial endobronchial ultrasound (ebus) and combination of both techniques.

current randomized clinical study is intended to compare three different modalities of navigation in bronchial tree - virtual bronchoscopy, radial ebus and combination of both techniques. around 300 patients with incidentally detected peripheral pulmonary lesions will be enrolled in 9 centers among russia. all patients after obtaining an informed consent will be randomized in 1:1:1 fashion to three study groups depending on type of navigation technique used. all patients will undergone navigational bronchoscopy with rebus (group a), vbn (group b) and rebus+vbn (group c), data on diagnostic efficacy and safety of each modality of navigation will be analyzed.

Eligibility criteria:
inclusion criteria: 1. patients with newly diagnosed unverified solitary or multiple (up to 3) peripheral pulmonary lesions (ppls) 2. ppl size 5 - 40 mm 3. actual chest ct scan (\<31 days prior to navigation bronchoscopy), collimation 1 mm, pulmonary window, dicom format 4. age \> 18 years 5. signed informed consent form 6. willing and ability to undergone a navigational bronchoscopy exclusion criteria: 1. unability to undergone navigation bronchoscopy for any reason 2. any malignant disease during last 36 months 3. known central endobronchial lesion of any cause 4. hiv-infection

Keywords: navigation bronchoscopy virtual bronchoscopy navigation radial endobronchial ultrasound bal tblb
simplified medical abortion in rural india

Conditions: Pregnancy

Summary: it is estimated that around 50 000 women die every year due to consequences of unsafe abortion (singh et al, 2009). a majority of these deaths occur in low-income countries where access to safe abortion care is limited. unplanned pregnancy and unsafe abortion thus place a huge burden on scarce medical resources. any improvement in comprehensive abortion care (cac) would mean important improvements for the concerned women and their families (singh, 2006) as well as for the societies at large. recommended improvements concern increased access to the safest and most cost-effective methods such as medical abortion provided at primary level facilities (singh et al, 2009). a cochrane review concludes that most randomised controlled trials within the field of medical abortion are conducted in high-income settings with good access to emergency health care services (kulier et al, 2004). a simplified regime for medical abortion, which could be used at primary level facilities, would contribute to the reduction of maternal mortality and morbidity related to unsafe abortions globally. however, there is a knowledge gap in order to determine if a simplified follow up of medical abortion is equally effective as the standard procedure in a low-income setting. the results will provide evidence-based information to be used in revising training and service delivery guidelines' in order to reduce maternal mortality and morbidity in both low and high-income setting.


Eligibility criteria:
inclusion criteria: * women presenting with a positive urine test and uterine size equivalent to or up to 9 +0 weeks (63 days) of gestation * opting for medical abortion and * residing in an area where follow-up is feasible. * woman agrees for a follow up contact at 10-14 days. exclusion criteria: * women with contraindications to medical abortions, * haemoglobin level less than 85 (hb \< 85) and * age less than 18 years.

Keywords: low sensitivity urinary hcg follow up medical abortion rural india rct
physical activity and academic achievement across the curriculum (a+paac)

Conditions: Intelligence; Obesity

Summary: there is currently considerable interest in both improving academic achievement (no child left behind) and reducing the rates of obesity and its associated negative health consequences in elementary school students. increased physical activity (pa) offers a potential intervention to address both issues. evidence is available which suggests an association of pa with both academic achievement and obesity, and an association between obesity and academic achievement. to provide increased pa while maintaining academic instruction time, we developed a program we call "physical activity across the curriculum" (paac) in which regular classroom teachers were trained to deliver academic lessons using moderate to vigorous physical activity (mvpa) for 20 minutes/d, 5 days/wk. this study is looking to compare academic achievement between students in elementary schools that participate in academic lessons taught through mvpa (paac) to students that do not (con).


Eligibility criteria:
inclusion criteria: * grade 2 or 3 student at one of the randomly selected elementary schools * students that agree to complete assessments * signed parental consent form * signed child assent form exclusion criteria: * students that do not agree to complete assessments

Keywords: academic achievement elementary school physical activity exercise
study of max-40279 in patients with relapsed or refractory acute myelogenous leukemia (aml)

Conditions: AML

Summary: this is a non-randomized, open-label, single-arm, dose-escalation phase i study to evaluate the safety and tolerability of max-40279-01 in patients with relapsed or refractory aml.

this is a two-part study comprised of a dose escalation part and a dose expansion part.

Eligibility criteria:
inclusion criteria: * males and/or females over age 18. * subject has morphologically documented relapsed or refractoryprimary aml as defined by the world health organization (who) 2016 criteria for which no established standard therapy is available. * ecog performance status of 0 to 2. * persistent chronic clinically significant non-hematological toxicities from prior treatment (including chemotherapy, kinase inhibitors, immunotherapy, experimental agents, radiation, hsct, or surgery) must be grade ≤ 1. * any anti-tumor treatment with radiation therapy, surgery, or immunotherapy wihtin 2 weeks prior to trial entry. * life expectancy of at least 3 months. * both men and women of reproductive potential must agree to use a highly effective method of birth control during the study and for six months following the last dose of study drug. exclusion criteria: * disease diagnosis of acute promyelocytic leukemia. * medical history of difficulty swallowing, malabsorption or other chronic gastrointestinal disease, or conditions that may hamper compliance and/or absorption of the tested product. * previously treated malignancies other than the current disease, except for adequately treated non-melanoma skin cancer, in situ cancer, or other cancer from which the subject has been disease-free for at least 5 years at the trial entry. * laboratory values not within the protocol-defined range. * concomitant disease or condition that could interfere with the conduct of the trial, or that would, in the opinion of the investigator, pose an unacceptable risk to the subject in this trial.
evaluation of the zynex blood volume monitor in healthy adult patients during a blood draw

Conditions: Blood Loss

Summary: non-invasive monitoring to measure changes in blood volume.


Eligibility criteria:
inclusion criteria: * healthy volunteers * between 18-35 years of age * weight between 130-200 pounds exclusion criteria: * known cardiac disease * recent caffeine intake * tobacco use in the (4) hours prior to screening * infection * pregnancy * hemoglobin \<13.5 g/dl

Keywords: blood loss
uterocervical angle in idiopathic polyhydramnios

Conditions: Preterm Labor

Summary: to evaluate the performance of uterocervical angle (uca) in the prediction of preterm labor in isolated polyhydramnios


Eligibility criteria:
inclusion criteria: * isolated polyhydramnios pregnancies * no previous systemic illnesses exclusion criteria: * abnormal pap smear * previous cesarean section * history of dilatation and curettage (d\&c) * history of loop electrosurgical excision procedure (leep) and cervical conization
effects of enamel matrix derivative in the treatment of peri-implant mucositis

Conditions: Mucositis; Peri Implant Mucositis

Summary: to evaluate the naturally occurring peri-implant mucositis (pm) treatment by means of non-surgical sub-marginal peri-implant instrumentation (nspi) with or without use of enamel matrix protein derivative (emd). specifically, the primary outcome of the present study compared the efficacy of nspi +emd with respect to nspi and placebo in the treatment of pm at 6 months follow-up by means of bop reduction. the secondary outcome evaluated the influence of possible predictors on the bop changes among all follow-up sessions.

patients (n° 54) with implants affected by pm were randomly assigned to test (nsmd+emd) or control procedures (nsmd + placebo). at baseline, 1, 3, 6 months, full-mouth plaque score (fmps), full-mouth bleeding score (fmbs), probing depth (pd), bleeding on probing (bop), modified gingival index (mgi), and modified plaque index (mpli) will assessed as well as levels of periodontal bacteria such as aggregatibacter actynomycencomitans, porphyromonas gingivalis, tannerella forsythia and treponema denticola. the bop reduction was set as a primary outcome and the patient was considered statistical unit. data were analysed to assess bop reduction at a 6-month follow-up and to identify significant predictors of implant-site bop through mixed generalized linear regression.

Eligibility criteria:
inclusion criteria: * age ≥18 years old; * implants with smooth necks supporting cemented or screw-retained single-unit crowns with at least one bop-positive site (berglundh et al., 2018), * implants placed in both maxilla and mandible * patients with gingivitis or treated periodontitis with the absence of residual pd ≥5 mm * presence at least of 2 mm of keratinized mucosa (kt) at implant sites exclusion criteria: * presence of systemic diseases; * pregnancy or lactating; * use of inflammatory drugs or antibiotics within 3 months prior to study recruitment; * implants with modified (i.e., micro-rough) necks; * interproximal open contacts between implant restoration and adjacent teeth; peri-implantitis (berglundh et al., 2018)

Keywords: enamel matrix derivative
effect of short-term chinese tea-flavor liquor consumption

Conditions: Cardiovascular Diseases

Summary: human studies of chinese liquor are sparse. the investigators hypothesize that short-term chinese tea-flavor liquor (tfl) consumption may be beneficial to inflammation biomarkers and cvd risk factors. guizhou meijiao liquor (gml) is a traditional chinese liquor, fermented from sorghum, corn, sticky rice, wheat and rice, while tfl is a novel chinese liquor fermented from above 5 grains plus green tea. forty-five volunteers(23 males, 22 females) were selected to participate a paralleled randomized trial drinking 30 ml two kinds of chinese liquors: tfl and gml respectively with meal every day for 28 days. serums of volunteers were collected for analyzing serum lipids, inflammation biomarkers and cvd risk factors. tfl could significantly decrease systolic blood pressure of males, but increase diastolic blood pressure of females. tfl could also decreased blood lipid of volunteers, especially for females. both liquor significantly decrease serum uric acid and glucose in males and females. the effect of the two liquors on inflammation biomarkers were complicated and needs further research work. tfl may possess more beneficial effect on cvd risk factors than gml probably because of the special fermentation products of green tea with other grains.


Eligibility criteria:
inclusion criteria: * healthy male and female volunteers exclusion criteria: * subjects with a history of liver disease, diabetes, or heart disease * smokers

Keywords: short term consumption chinese liquor serum lipids uric acid inflammation biomarkers
menopur mixed protocol

Conditions: Infertility

Summary: the objective of this study was to compare the fertilization rate between the combination of menopur and bravelle mixed in the same syringe and menopur alone, both administered subcutaneously (sc), in subjects undergoing assisted reproductive technology (art). additionally the study assessed subjects' ability to mix and store the combination of menopur and bravelle and to assess safety of the menopur and bravelle combination.


Eligibility criteria:
main inclusion criteria: * infertile pre-menopausal female subjects * documented history of infertility (eg., unable to conceive for at least 1 year, or 6 months for women ≥36 years of age, or women with bilateral tubal occlusion or absence, or subjects who require donor sperm). * subject's male partner with semen analysis that was at least adequate for intracytoplasmic sperm injection (icsi) within 6 months prior to the subjects beginning down-regulation with gonadotropin-releasing hormone (gnrh)-agonist. partners with severe male factor requiring invasive or surgical sperm retrieval or donor sperm could have been used. * anti-mullerian hormone (amh) \> 1 ng/ml and \< 3 ng/ml at screening. * eligible for in-vitro fertilisation (ivf) or icsi treatment. main exclusion criteria: * oocyte donor or embryo recipient; gestational or surrogate carrier * previous ivf or assisted reproductive technology (art) failure due to a poor response to gonadotropins. poor response was defined as development of ≤ 2 mature follicles or history of 2 previous failed cycle cancellations prior to oocyte retrieval due to poor response. * inadequate number of oocytes, defined as fewer than 5 oocytes retrieved in previous art attempts. * subject's male partners with obvious leukospermia (\>2 million white blood cells \[wbc\]/ml) or signs of infection in semen sample within 2 months of the start of subject's pituitary down-regulation. if either of these conditions existed, the male was to be treated with antibiotics and retested prior to subject's pituitary down-regulation. * undergoing blastomere biopsy and other experimental art procedures. * body mass index (bmi) of ≤18 and ≥32 kg/m\^2

Keywords: assisted reproductive technology
effects of time of sleep restriction in obesity

Conditions: Obesity; Sleep Restriction; Appetite Regulation; Eating

Summary: the purpose of this study is to determine the effect of different time of sleep restriction on control of food intake and metabolism of obese and normal subjects.

the reduction of sleep time has now become a common habit, driven by the demands and opportunities of modern society. some studies have suggested that sleep restriction would be an important factor in predisposing to obesity. however studies of sleep restriction in obese individuals have not yet been conducted. still, the time of sleep restriction varies greatly between studies, making it difficult to compare results. the investigators aim to recruit 20 young adults, 10 obese and 10 normal weight individuals. the study will be conducted as a randomized, crossover study with three conditions. each participant will be subjected to reduction of the beginning of sleep (from 3-7h), reduction of the end of sleep (from 23-3h), and normal sleep (from 23-7h), in random order, for three consecutive nights. in each condition, subjects will stay for 4 days in the laboratory. three control meals will be offered. visual analogue scales will be applied before and after each meal to assess hunger and appetite for different food categories. blood samples will be collected hourly during 24 hours.

Eligibility criteria:
inclusion criteria: * obese (bmi\>30) and normal weight (bmi between 19 and 24,9) * regular time of sleep between 6.5 and 8 hours exclusion criteria: * self-reported sleep problems (pittsburgh sleep quality index score \>5); * obstructive sleep apnea (ahi \> 5 in polysomnography) * night work; * variable sleep habits or habitual daytime naps; * regular physical exercise (\>3 hours/week); * excessive intake of alcohol (\>7 drinks/week); * excessive intake of caffeine (\>300 mg/day); * smoking; * substance abuse; * use of prescription medications or over-the-counter drugs affecting sleep or metabolism; * chronic diseases (e.g. cancer, asthma, back pain, thyroid disease, heart disease, diabetes, etc.) * history of neurological, medical or sleep disorders; * trans-meridian travelling the last month; * chronotype: extreme morning or extreme evening * unable to comply with the protocol.