Kornimate/medical-research-clean huggingface dataset:
effects of different periodontal treatments on quality of life in patients with periodontitis

Conditions: Quality of Life

Summary: in this study, the quality of life of patients with stage 3 grade c periodontitis who underwent surgical and non-surgical periodontal treatments was evaluated. patients were compared based on their quality of life using ohip-14 and ohrqol-uk questionnaires, as well as a vas scale, against those who did not receive periodontal treatment, those who received only phase 1 treatment one month prior, and those who underwent periodontal surgical treatment three months prior.

currently, the most commonly used reliable scales to measure oral health-related quality of life are the ohip-14 (oral health impact profile) and ohrqol-uk questionnaires. fifty patients with stage 3 and grade c whose clinical periodontal records (pi, gi, pd and bop) were obtained were included in the study. ohrqol-uk, ohip-14 questionnaires and vas were applied at the first session (t1). initial periodontal treatment (scaling, polishing and oral hygiene education) was performed, and non-surgical periodontal treatment (root surface debridement under local anesthesia) was performed in the next session. three to four weeks after this treatment, patients were recalled for follow-up and all clinical indices and questionnaires were repeated (t2). after re-evaluation, the patients were divided into a surgical group (23 patients) and a non-surgical group (27 patients). open flap debridement was performed in areas requiring surgery (radiologic bone loss and scd\>5mm). patients were recalled 12-14 weeks after surgery and all indices and questionnaires were repeated (t3).

Eligibility criteria:
inclusion criteria: * literate * over 18 years of age * willing to voluntarily participate in the study * no mental retardation or any other disorder that would impede communication exclusion criteria: * presence of any systemic disease affecting periodontal tissues or use of medication that impacts periodontal health * pregnancy or lactation * having undergone periodontal treatment in the past 6 months

Keywords: periodontitis quality of life vas ohip-14 ohrqol-uk
aptus at home: co-design of a home-based monitoring system for anaemia

Conditions: Anemia; Iron Deficiency Anemia

Summary: co-design of a home-based anaemia monitoring system with participants who have previous diagnosis of anaemia.

the device/ monitoring system being developed is called aptus home. aptus home measures the haemoglobin and haematocrit levels in blood from a single drop of blood. by measuring these blood parameters, participants are able to monitor anaemia in participants' homes. the use of the device will take place in the participant's home to simulate what the investigators believe will be the ideal location for people who would prefer to self-manage their condition. this study is a unique opportunity to gain feedback on the future design and development of a home-based monitoring system through user evaluation. as this is an adaptive/ iterative study design, this will give the sponsor the opportunity to make changes to the user interface and user platform based on the feedback received from the end user.

Eligibility criteria:
inclusion criteria: * prior diagnosis of anaemia * commitment to perform finger pricking to use the device every two weeks and complete 2 monthly questionnaires * participant's willingness to participate in 1 to 1 interviews and, or focus groups * understands and has a good level of spoken and written english exclusion criteria: * no prior diagnosis of anaemia * not committed to perform two weekly finger pricks to use device and complete 2 monthly questionnaires * unwilling to attend interviews and focus groups * doesn't have a good level of written and spoken english
ai-based system for lung tuberculosis screening: diagnostic accuracy evaluation

Conditions: Tuberculosis, Pulmonary

Summary: testing of ai solutions to assess diagnostic accuracy for tuberculosis detection.

tuberculosis remains a key problem of modern medicine. new approaches for burden overcoming should be proposed. new screening strategies may include artificial intelligence (ai). an ai-based system for chest x-ray analysis and triage ("normal/tuberculosis suspected") have been developed and trained. a special data-set was prepared. there are 238 normal x-rays and 70 x-rays with lung tuberculosis in data-set. the data-set was randomly divided into 2 samples: * sample n1 (n=140) with ratio "normal: tuberculosis" 50:50, * sample n1 (n=150) with ratio "normal: tuberculosis" 95:5. both samples will be analysed by ai-based system. results will be quantified using diagnostic accuracy metrics: sensitivity and specificity, positive and negative predictor values, likelihood ratio, and area under the roc (receiver operating characteristic) curve.

Eligibility criteria:
inclusion criteria: * no pathology in a lung on chest x-ray * signs of lung tuberculosis on chest x-ray exclusion criteria: * any pathology in the lungs (except tuberculosis)

Keywords: ai deep learning tuberculosis radiology x-ray e-health screening chest artificial intelligence
reproducibility of computed tomography

Conditions: Tuberculosis; Pleural Effusion

Summary: thus, the aim of this study was to evaluate the reproducibility of the computed tomograph scan three-dimensional reconstruction method for the measurement of the tb pleural effusion volume in clinically stable patients.

speed, accuracy, and precision in the quantification of pleural effusion are of critical importance as it determines whether or not thoracocentesis should be carried out and which technique should be employed for such a procedure. this study evaluates the precision of thoracic computed tomography with three-dimensional (3d) rebuilding in determining the volume of tuberculosis pleural effusion.twenty patients with pleural effusion were screened and invited to take part in the study. each patient underwent two computed tomography scans, before and after one month of treatment for tuberculosis, a total of 40 exams. these were evaluated by two expert radiologists. in conclusion, the quantification of the pleural effusion volume by using thoracic ct with volumetric three-dimensional reconstruction is a highly reproducible method.

Eligibility criteria:
inclusion criteria: * patients age 18 years with a confirmed diagnosis of pleural tb effusion . * signed out an informed consent term exclusion criteria: * patients with human immunodeficiency virus (hiv).

Keywords: tuberculosis pleural effusion computed tomography
buddy tape vs. splint for metacarpal shaft fracture recovery

Conditions: Non-thumb Metacarpal Shaft Fracture

Summary: the goal of this clinical trial is to see if buddy tape can treat shaft fracture of hand long fingers as well as splint. the main question it aims to answer is: two months after the fracture, are the hand activities as good with buddy taping as with splint? researchers will compare buddy tape group to splint group to see if the strength of the arm is not lower with buddy tape. participants will attend 4 visits after receiving either buddy tape or splint, to control their hand strength and the correct healing of their franture.

patients will be identified in the emergency ward after x-rays are positive for a non-thumb metacarpal fracture. if they consent to participate in the study, they will be put into either the buddy taping or the short arm splint group. this decision will be made through randomization, and the physician will not select which group the patient is in. as in routine practice, the patients are seen again on d15 ± 3 days, d30 ± 5 days and d60 ± 5 days in an orthopedic consultation with x-ray to control the hand face, strict profile and 3/4. both devices are removed at the check-up consultation on day 30 ± 5 days. the patients will then attend the end of trial visit at day 90 ± 5 days in an orthopedic consultation with x-ray. no specific act is added by this research.

Eligibility criteria:
inclusion criteria: 1. adult patient 2. fingers 2 to 5 metacarpal shaft fracture, little or no displacement 3. tilt less than or equal to thirty degrees 4. no rotation disorder 5. patient who has given consent to participate in the study and has signed an informed consent exclusion criteria: 1. surgical treatment indicated 2. patient pregnant or likely to be pregnant 3. patient who does not speak or understand french 4. subject under guardianship or curatorship 5. subject not beneficiary of a social security system.

Keywords: metacarpal shaft fracture
artificial intelligence and postoperative acute kidney injury

Conditions: Non-cardiac Surgery

Summary: the main objective of this study is to develop and validate an artificial intelligence model that predicts postoperative acute kidney injury.

postoperative acute kidney injury is known to increase the length of hospital stay and healthcare cost. a lot of risk prediction models have been developed for identifying patients at increased risk of postoperative acute kidney injury. recent advances in artificial intelligence make it possible to manage and analyze big data. prediction model using an artificial intelligence and large-scale data can improve the accuracy of prediction performance. furthermore, the use of an artificial intelligence may be a useful adjuvant tool in making clinical decisions or real-time prediction if it is integrated into the electrical medical record systems. however, before implementing an artificial intelligence model into the clinical setting, prospective evaluation of an artificial intelligence model's real performance is essential. however, to our knowledge, there was no artificial intelligence model for prediction of postoperative acute kidney injury, which was prospectively evaluated. therefore, we aimed to develop an artificial intelligence model which predicts postoperative acute kidney injury and evaluate the model's performance prospectively.

Eligibility criteria:
inclusion criteria: * adults patients undergoing non-cardiac surgery exclusion criteria: * age under 18 years * surgery duration \< 1 hour * transplantation surgery * nephrectomy * cardiac surgery * patients who had severe kidney dysfunction preoperatively as follows: * serum creatinine ≥ 4 mg/dl * estimated glomerular filtration rate \<15 ml/min/1.73m2 * history of renal replacement therapy * patients who had no results of preoperative or postoperative serum creatinine

Keywords: artificial intelligence postoperative acute kidney injury prospective validation
effectiveness of skit video to improve oral hygiene status of children with hearing impairment

Conditions: Hearing Impaired Children

Summary: introduction: oral health is considered as a vital component of overall health and its importance in children may not be disregarded. in children with hearing impairment, communication barriers may hamper their understanding of oral hygiene practices, making them particularly vulnerable to dental problems. objective: the objective of this study was to compare effectiveness of skit video, pictorial and sign language interventions to improve oral hygiene status of children with hearing impairment. methods: sixty children were completed the study and allocated randomly into each group with twenty children as follows: group a: skit video, group b: pictorial, and group c: sign language. mean gingival and ohi scores were recorded before and after implementation of interventions. oral hygiene habits, oral hygiene and gingival index scores were recorded by structured questionnaire.


Eligibility criteria:
inclusion criteria: * children with hearing impairment and total hearing loss at birth * aged 7 to 20 years for both genders, * minimum of 20 teeth in the oral cavity * children with mild, moderate, and severe gingivitis exclusion criteria: * children with dental plaque covered more than two-thirds of their tooth surface, had a plaque score of \>1.0 * children with fair to poor oral hygiene * children who had previously participated in any activity or programme promoting oral health within the previous six months * children with mild to moderate hearing loss * children taking long-term antibiotics * children who had used mouthwash within the previous three months * children with any known systemic diseases * presence of extensive dental calculus * uncooperative children
phox2b mutation-confirmed congenital central hypoventilation syndrome in a chinese family: presentations from newborn to adulthood

Conditions: Central Alveolar Hypoventilation Syndrome

Summary: detect the phox2b mutation-confirmed congenital central hypoventilation syndrome

background: congenital central hypoventilation syndrome (cchs) is characterized by compromised chemo-reflexes that results in hypoventilation during sleep. recently, a heterozygous phox2b gene mutation was identified in cchs. this report was made to increase physicians' awareness of this rare disease. methods: a chinese family of cchs with presentations from newborn to adulthood and genetic analysis confirming the phox2b mutation was analyzed. after identifying central hypoventilation in an adult male (index case), clinical evaluation was performed on the complete family, which consisted of the parents, five siblings, and five offsprings. in addition, pulmonary function test, overnight polysomnography, arterial blood gas, and hypercapnia ventilatory response, and genetic screening for phox2b gene mutations were performed on living family members.

Eligibility criteria:
inclusion criteria: * members of familiar congenital central hypoventilation syndrome exclusion criteria: * refuse to participate study

Keywords: sleep apnea, phox2b, hypoventilation, polysomnography
ultrasound measured epidural depth for midline approach in pediatric patients with scoliosis: prospective observational study

Conditions: Scoliosis

Summary: the purpose of this study was to 1. investigate the degree of agreement between the ultrasound-measured depth (in the transverse median and paramedian sagittal oblique plane) and the actual depth to the epidural space in pediatric patients with scoliosis. 2. investigate the quality of ultrasound view for detecting ligamentum flavum and dura mater.


Eligibility criteria:
inclusion criteria: 1. pediatric patients (aged 3-14 years) with scoliosis (cobb angle \>10 degree) scheduled for correctional osteotomy of the lower extremity and requesting epidural analgesia for postoperative pain control exclusion criteria: 1. contraindications to epidural analgesia (local infection, blood clotting disorder, anatomical abnormality, sepsis, etc.) 2. if all of the parents of the subject are foreigners or illiterate (if the parents of the subject can not read the agreement)
radial or focus extracorporeal shock wave therapy in epin calcanei

Conditions: Spur, Heel

Summary: objective: the aim of the study was to investigate the effectiveness of radial and focused eswt treatment on pain, function, and size of the calcaneal spur in patients with a clinical and radiological diagnosis of epin calcanei. methods: a total of 112 patients aged between 18 and 95 years were randomly divided into two groups: group 1 received reswt (2.4 bar 12 hz 2000 beats), and group 2 received feswt (0.14 bar 14 hz 1000 beats) three times a week for three weeks. all patients were evaluated using the visual analog scale (vas)-pain and foot function index (ffi) before and after the treatment, at 4 weeks and 12 weeks. epin size was measured radiographically in the patients before and after the treatment at the 12-week follow-up.


Eligibility criteria:
inclusion criteria; * presence of heel pain for at least four weeks, * receiving no medical treatment, injection, physical or surgical treatment for the last four weeks and * agreed to participate in the study. exclusion criteria: * history of fracture or surgery, * polyneuropathy, * rheumatological diseases, * coagulation disorders, * tumor, * thrombosis, * soft tissue or bone infection, * pregnancy and lactation, * epilepsy, * presence of a pacemaker.
diffusion mri; predictive value for cervical uterine cancer recurrence

Conditions: Uterine Cervical Cancer; Diffusion-weighted MRI; Recurrence

Summary: uterine cervical cancer is the second most common female malignancy. therapy monitoring is essential to detect early recurrence. diffusion-weighted magnetic resonance imaging is an emerging mri imaging technique which has a potential value for the detection of primary and recurrent disease and for the assessment of response to therapy. the purpose of this project is to evaluate the predictive value of dwi during and after therapy in the prediction of recurrence of cervical uterine cancer. it will be considered whether dwi is able to provide early information about the response to therapy. this could enable the identification of less- or non-responsive tumors and in this way therapy can be adapted as soon as possible. hence the investigators could offer the patient a more efficient treatment scheme and a reduction in toxicity related to the treatment could be established.


Eligibility criteria:
inclusion criteria: * patients diagnosed with cervical uterine cancer are, on a voluntary basis, enrolled in the study. these are patients who either underwent curative chemoradiation (mainly patients with advanced stage cancer) or neoadjuvant chemotherapy (predominantly in patients with early stage cancer) before undergoing surgery. exclusion criteria: * patients with known contra-indications for mri (cardiac pacemakers, cochlear implants, claustrophobic patients) will be excluded from this study. and so are patients with contra-indications to gadolinium-based contrast agents and patients with a known restricted renal function (gfr \< 30 ml/min).

Keywords: uterine cervical cancer diffusion-weighted mri recurrence
cytokine profile of the uterine secretome after therapeutic endometrial scratching

Conditions: Infertility, Female

Summary: this study investigates the impact of endometrial scratching on endometrial secretion, when correlated to pregnancy.


Eligibility criteria:
inclusion criteria: * ivf or icsi patients with ≥1 previous implantation failure, despite transfer of a top quality embryo or blastocyst. * antagonist treatment * fsh: 2-12 iu/l * bmi: 18-32 * regular menstrual cycle * written consent exclusion criteria: * suspected intrauterine abnormalities planned use of specialized media or aha

Keywords: endometrium, cytokines, endometrial secretion, implantation, endometrial scratching
pumch dementia longitudinal cohort study

Conditions: Dementia; Dementia, Vascular; Dementia With Lewy Bodies; Dementia, Mixed; Dementia Alzheimers; Dementia Frontal; Dementia, Mild

Summary: the pumch dementia cohort is a hospital-based, observational study of chinese elderly with cognitive impairment.

in china, the burden of dementia is increasing, which has a major impact on medical care, society, and the economy. in order to solve this important public health problem, a cohort study of cognitive impairment in the elderly should be carried out. we designed an age stratified dementia cohort and tried to to clarify the risk and prognostic factors, disease characteristics, cognitive evaluation, biomarkers, diagnosis, treatment of dementia and its subtypes in china. it is of great significance to establish a relatively comprehensive dementia database, improve the level of clinical diagnosis and treatment of cognitive impairment, and formulate prevention and treatment strategies for dementia. baseline data collection and cohort establishing: detailed clinical information including demographic data, clinical history, past history and physical examination are collected. formatted neuropsychological battery is used in all patients, including screening tests (mmse, moca-pumch, adl, had) and domain specific evaluation (memory, executive function, visual spatial, calculation, language). samples including serum, csf, urine, skin, saliva are stored. every patient is followed up every 6 months. autopsy brain tissue will be collected if patients died. the main contents of this study are following: 1. explore the relationship between lifestyles, stress and dementia. 2. assess risk factors for dementia. 3. evaluating behavioral and psychological symptoms of dementia. 4. improve the long-term follow-up cohort stratified by age and dementia type and construct the high standard information and sample bank. 5. explore biomarkers of different groups of dementia, incorporating neuropsychology, multi-model neuroimaging, metabolics and proteomics based fluid biomarkers as well as genetic biomarkers. autopsy after clinical follow up help to verify the biomarkers. 6. establish and promote standardized and consistent biomarker detection methods. 7. dementia education and training. 8. use machine learning methods to establish computer-assisted dementia diagnosis system and evaluation system. establish prediction models for the progression of dementia.

Eligibility criteria:
inclusion criteria: * neurodegenerative dementia diagnosis based on 2011 nia-aa criteria of dementia * fixed care giver and can follow up regularly exclusion criteria: * not demented, including mci * systemic severe diseases and severe vision or hearing problem effecting follow up and neuropsychological evaluation * without fixed care giver * reject informed consent * expected life shorter than 2 years
taxol/ carboplatin as first line therapy in patients with epithelial ovarian cancer

Conditions: Ovarian Cancer

Summary: the combination of paclitaxel and carboplatin in a three weeks schedule has emerged as the current standard approach for the adjuvant treatment of ovarian cancer. based on a phase i study now a multi-center phase ii-trial was conducted.


Eligibility criteria:
inclusion criteria: * histologically-confirmed epithelial ovarian cancer of figo stage iib - iv * life expectancy of more than three months * ecog performance status less than 3 * laboratory parameters within the normal range, including a glomerular filtration rate (gfr) greater than 60 ml/min, serum creatinine levels below 1.6 mg/dl, liver transaminases less than two times the normal levels, bilirubin concentrations below 1.5 mg/dl, adequate bone marrow function as indicated by a neutrophil count greater than 1,500/µl, and a platelet count greater than 100,000/µl. * written informed consent exclusion criteria: * suffering from secondary malignancy or underlying serious, uncontrolled concurrent medical or psychiatric disease * radiotherapy within 4 weeks for study entry

Keywords: ovarian neoplasms paclitaxel, carboplatin clinical trials, phase ii first-line chemotherapy weekly therapy schedule
prevalence and reversibility of lung hyperinflation in asthma

Conditions: Asthma

Summary: the aim of this observational study is to evaluate the pulmonary hyperinflation and its immediate reversibility to a short acting beta2 agonist test in uncontrolled persistent asthmatic patients with dyspnea.

the other objectives are : * the evaluation of the hyperinflation defined by an increase of the residual volume (rv), * the observation of the relationship between the hyperinflation and the asthma characteristics, * the study of the improvement of the functional parameters after a reversibility test * the evaluation of the correlation between hyperinflation parameters evolution, chest tightness and dyspnea

Eligibility criteria:
inclusion criteria: * patient with a diagnosis of uncontrolled persistent asthma (act \ /= 1 * patient requiring a check-up including a pulmonary function test by plethysmography with a reversibility test exclusion criteria: * patient participating to an other clinical trial or having participated to a clinical trial with medicine in the last 3 months

Keywords: distal airways hyperinflation reversibility