Kornimate/medical-research-clean huggingface dataset:
lactose intolerance at ibs

Conditions: Lactose Intolerance

Summary: this cross-sectional study aims to determine the prevalence of lactose intolerance among patients with chronic diarrhea, assess its correlation with age and gender, and evaluate common symptoms in affected patients. the study will collect demographic data, conduct lactose intolerance testing via pcr, and use a symptom questionnaire.

the study is designed as a cross-sectional analysis conducted at a single healthcare center. its primary objectives are: to determine the point prevalence of lactose intolerance in patients suffering from chronic diarrhea (lasting more than four weeks). to explore potential correlations between lactose intolerance and demographic factors such as age and gender. to identify the most common symptoms associated with lactose intolerance in this patient population. methodology: data collection: demographic information (age, sex, medical history, and diarrhea duration) will be gathered. lactose intolerance testing: polymerase chain reaction (pcr) will be employed to diagnose lactose intolerance. symptom questionnaire: a standardized questionnaire will be administered to document symptoms like abdominal pain, bloating, flatulence, diarrhea, and nausea.

Eligibility criteria:
inclusion criteria: * all patients with ibs diarrhea dominant type meet rome criteria attending at al-rajhy university hospital during 6 months (from march to september). a patient must have recurrent abdominal pain (at least 1 day per week in the last 3 months) associated with at least two of the following: 1. related to defecation (pain improves or worsens with bowel movements). 2. change in stool frequency (diarrhea or constipation). 3. change in stool form (appearance) (loose, watery, hard, or lumpy). * patients aged \>18 years. * both males and females exclusion criteria: * -patient aged\<18 years old. * patients with chronic diarrhea don't meet rome criteria * patients with malignancies

Keywords: lactose intolerance chronic diarrhea
evaluation of predictive value of multisite intracardiac echocardiography during imaging of structure and function of left atrial appendage in comparison to transesophageal echocardiography

Conditions: Atrial Fibrillation

Summary: this is a 2- component, single center study, witch aims to evaluate the efficacy of multisite intracardiac echocardiography (mice) imaging of left atrial appendage (laa) and in detecting thrombus located in laa as compared to transesophageal echocardiography (tee). the study group will consist of patients eligible for atrial fibrillation (af) ablation procedure (component i) or cardioversion (component ii). first component will enroll 100 patients; these patients will undergo clinically indicated tee \& cardiac catheterization procedures with ice(af ablation). second component will enroll 15-20 patients with af or atrial flutter in whom a thrombus in laa was detected by tee prior to electrical cardioversion. the ice probe will be located in multiple positions in the right atrium (ra), coronary sinus (cs), pulmonary artery (pa), right ventricular outflow tract (rvot) and esophagus. this will enable the investigators to compare sensitivity and specificity of mice and tee. this study will examine two hypotheses in af patients undergoing invasive cardiac procedures: hypothesis 1: that ice has comparable efficacy to tee in visualization of laa from multiple positions (ra,cs,pa,rvot and esophagus ). this will be evaluated during the component i of the study. hypothesis 2: that ice can identify low risk patients, chads score \< 2,0 in whom immediate cardioversion during the procedure is as safe as based on conventional strategy.


Eligibility criteria:
inclusion criteria: 1. patients with paroxysmal/persistent af 2. patients with or without structural heart disease. 3. men or women aged 18 years or older. 4. patients undergoing an invasive catheterization procedure including right heart catheterization. 5. patients who give an informed consent for participation in the study. 6. patients who have undergone a trans-esophageal echocardiogram within the last 48 hours. patient witch chads2 score \> 2 exclusion criteria: 1. patients in whom placement of an ice catheter for adequate atrial visualization is technically not feasible (right atrium or esophagus). 2. women of child bearing potential, in whom pregnancy cannot be excluded. 3. patients with any medical condition or social circumstance, which in the opinion of the investigator, would make the patient's successful completion of the study doubtful
comparison of bowel ultrasound & mr enterography in the follow-up of previously diagnosed pediatric small bowel crohn disease

Conditions: Crohn Disease

Summary: to establish the accuracy of bowel ultrasound in the follow-up of known (previously diagnosed) pediatric small bowel crohn disease, using mr enterography (magnetic resonance imaging technology used to obtain detailed images of the small bowel) as the reference standard.

25-30% of individuals with crohn disease present during childhood or adolescence, and the incidence is rising. mre (magnetic resonance enterography) is considered the standard of care for imaging of pediatric small bowel crohn's disease. bowel ultrasound is an emerging technology for bowel assessment and offers several advantages over mre, including lower cost, shorter exam time, and lack of need for sedation and contrast materials and bowel medication. the researchers goal is to assess the accuracy of bowel ultrasound in the follow-up of known pediatric small bowel crohn disease using mre and the reference standard.

Eligibility criteria:
inclusion criteria: * 18 years of age or younger * subjects with known small bowel crohn disease undergoing a clinically ordered imaging follow-up with mr enterography. exclusion criteria: * subjects with suspected or newly diagnosed crohn disease * subject who have the following in their body may not undergo mre imaging: * metal chips/shrapnel * surgical clips * artificial joints * metallic bone plates * prosthetic devices * heart pacemakers * clips in or around the eye balls * artificial heart valves * bullet fragments * chemotherapy or insulin pumps
the therapeutic effects of topiramate and metformin on second generation antipsychotics-induced obesity

Conditions: Obesity

Summary: the primary aim of the study is to investigate the efficacy of metformin and topiramate on second-generation antipsychotic-induced obesity. the secondary domain we look at is the adverse effects of both drugs. the investigators hypothesize that metformin and topiramate are effective in treating obesity induced by second-generation antipsychotics.


Eligibility criteria:
inclusion criteria: 1. diagnosis: schizophrenia or schizoaffective disorder 2. age: 20 to 65 3. bmi\>27 4. receiving second-generation antipsychotics(olanzapine, clozapine, quetiapine, risperidone, amisulpride, zotepine) exclusion criteria: 1. allergy to metformin or topiramate 2. currently taking metformin or topiramate 3. currently taking drugs that may interact with topiramate, including carbamazepine, eslicarbazepine, oxcarbazepine, phenobarbital, phenytoin, primidone, amitriptyline, lithium, metformin, propranolol, and sumatriptan. 4. being pregnant or planning to become pregnant during the study period, 5. history of hypertension, dm, liver or renal function impairment, cardiovascular disease, cva, or neurological disorders 6. history of hypoglycemia 7. history of suicidal attempt 8. current scale of hamilton depression rating scale\>8

Keywords: metformin topiramate obesity metabolic syndrome
p400 for stage ii-iv pressure ulcers in home and extended care

Conditions: Pressure Ulcers

Summary: to assess the efficacy of a pressure ulcer treatment mattress, the p400 mattress, in the treatment of multiple stage ii or one or more large stage iii or iv pressure ulcers in the home care and extended care (nursing home) environment.

subjects will be recruited from those presenting to the wound clinic and meet the inclusion criteria. a total of 30 evaluable subjects will be recruited for this study from up to 2 wound care clinics /home health agencies (15 in home care and 15 in extended care). subjects will be followed by weekly wound assessments for a period of 12 weeks or until their wounds heal. the outcome measurement is the rate of healing over the 12 week period.

Eligibility criteria:
inclusion criteria: 1. subject has multiple stage ii pressure ulcers or at least one stage iii or iv pressure ulcer(s) (as per national pressure ulcer advisory panel staging guidelines) located either on the trunk or pelvis (which would include trochanter and ischial ulcers ) having a clean wound bed of less than or equal to 25% necrotic tissue at the base of the pressure ulcer. 2. subjects may have heel ulcers, however these ulcers may not be considered a target study ulcer. 3. subject, or legally authorized representative is able to provide informed consent 4. subject weighs between 70 and 350 pounds 5. subject's nutritional status is thought to be adequate to support wound healing 6. subject qualifies for a group 2 support surface (target study ulcer must be at least 8 cm\^2 in area to qualify) exclusion criteria: 1. subject's target ulcer is unstageable due to eschar or necrosis or a suspected deep tissue injury may be located at the base of the wound. 2. subject has unresolved systemic infection, or pressure ulcer infection, or a history of osteomyelitis, or greater than 25% eschar or necrotic tissue present in the wound bed. 3. patient has already been enrolled in this study 4. patient has a recent history of non-compliance with pressure ulcer offloading, repositioning, or other areas of the treatment care plan, which would jeopardize wound healing if continued. 5. care plan goals are palliative

Keywords: pressure ulcer treatment mattresses home care extended care wound measurements
new mri sequences in spine and joint

Conditions: Degeneration of Spine and Osteoarticular

Summary: low back pain and osteoarticular degeneration or injury is the leading worldwide cause of years lost to disability, accounting for 17 % of all patients with disabilities and its burden is growing alongside the increasing and aging population. the anatomical regions of the intervertebral disc include the central nucleus pulposus, the peripheral fibrocartilaginous annulus fibrosus, and the superior and inferior cartilaginous endplates (cep). the cep is a thin layer of hyaline cartilage located between the avascular intervertebral disc and the bony vertebral endplate. the endplate cartilage consists of chondrocytes interspersed throughout an extracellular matrix of proteoglycans, collagen (types i and ii), and water. it plays an important role in the function and homeostasis. the cep has been considered the pathway between the largely avascular disk tissues and the blood supply of the vertebral body and thus provides nutrition for disk cells. many musculoskeletal tissues, including the cep, cartilage-bone interface of articular joints, entheses, tendons, and ligaments, have components with very short t2 values (much less than 1 msec), which are orders of magnitude shorter than that of the nucleus of the disk (\~100 msec). in a conventional pulse sequence, such as proton density-weighted spin-echo (se) or fast se, with standard clinical section profile, the minimum echo time (te) is typically 10 msec, which is much longer than that needed to capture the short-lived signal from these tissues. recently, ultrashort echo sequence ute technology has been introduced, and the te time can be as low as 0.008ms. this range of te is sufficient to capture signals from the cartilage endplate before it decays. with using new mri technology, such as ir-ute, ute-mt, ute-t2\*mapping, maigc, dti, and ivim, which can quantitative tissues that have previously been "invisible" at conventional mr imaging, and provide imaging basis for early diagnosis of injury at molecular level. the purpose of this study was to investigate the clinical application value of different mri sequences in spine and joint.


Eligibility criteria:
inclusion criteria: * 1.the patient had history and clinical symptoms of low back pain and joint sports injury 2.the patient had a history of osteoporosis; 3.there was no contraindication of mri; 4.the patient who has clear lumbar intervertebral disc degeneration or herniation or osteoporosis or joint sports injury found by routine ct or mri examination, and the clinical symptoms were consistent with the image. exclusion criteria: * 1. patients with previous history of lumbar or joint surgery; 2. patients with congenital bone deformity; 3. patients with history of lumbar tumor and infection; 4. cognitive function is limited or mental illness can not cooperate with imaging.

Keywords: magnetic resonance imaging low back pain disk degeneration ultrashort echo time osteoarticular degeneration
impact on muscle strength, quality of life and functionality in individuals submitted to hip arthroplasty: a prospective study.

Conditions: Arthroplasty Complications; Arthropathy of Hip

Summary: introduction: total hip arthroplasty has been increasingly used as a means of treating the various pathologies of this joint. however, this surgical reconstruction initially brings important deficits in subjects submitted, such as: inhibition of muscle strength, limitation of range of motion and functional deficit. therefore, an immediate physiotherapeutic treatment is necessary in the short and long term, taking into account both biomechanical issues and the quality of life of these individuals. objective: to evaluate the clinical evolution of individuals submitted to total hip arthroplasty in the ten year period. method: twenty individuals submitted to unilateral total hip arthroplasty will be evaluated by the medical group of hip surgeries of the brotherhood of santa casa de misericórdia of são paulo, during a period of ten years. these individuals will undergo a primary clinical evaluation and after signing the consent form, will be evaluated functionally with the harris hip score and whoqol-bref questionnaires and physically with the analysis of muscular strength through manual dynamometry to measure the strength level of the muscles involved in the bilateral coxo-femoral joint, such as abductors, adductors, flexors, extensors, internal rotators, external rotators, knee joint, such as extensors and flexors, and ankle, plantar flexors. finally, they will be referred to the kinematic gait analysis, to identify the functional characteristics of these individuals, through reflexive markers at specific anatomical points, where they will walk for 5 minutes on a treadmill at a speed of 1.5km per hour.


Eligibility criteria:
inclusion criteria: * the inclusion criteria in the study will be: patients submitted to total hip arthroplasty between 2 years (24 months - 35 months), 5 years (60 months - 71 months) and 10 years (120 months - 131 months), age between 50 and 80 years and sign the terms of free and informed consent exclusion criteria: * the exclusion criteria will be: patients with a history of prosthesis dislocations or revision of the arthroplasty, pain in the hip or lower limb region, asymmetry of the lower limbs greater than 2 centimeters, previous surgeries in the lower limbs, limitation of range of motion in the joint (impossible to perform muscle strength tests), use of antidepressive drugs or analgesics of continuous use, chronic diseases not controlled (hypertension, rheumatoid arthritis and diabetes) and the presence of neuromuscular pathologies

Keywords: arthoplasty gait muscle strenght quality of life
the effect of food and beverage based nutritional supplements in recipients of home care services at risk of malnutrition

Conditions: Malnutrition

Summary: malnutrition increases the risk of complications and predisposes ti infections through impaired immune response and wound healing. healthcare costs related to the management of malnourished patients is estimated to be more than double the amount spent managing non- malnourished the objective of this study is to examine the effect of newly developed energy and nutrients-dense beverage product on the nutritional status among patients at risk of malnutrition.

malnutrition is a complex state described as a deficiency of energy, protein and other nutrients causing measurable adverse effect on body tissue, function and clinical outcome. oral nutritional supplementation has in multiple individual trials and meta-analyzes shown an increased total energy intake and protein intake in patients in hospital settings as well as in the community. the largest producer of dairy products in norway, tine as released a new milk based energy- and nutrient dense product, called e+. the initiative behind this was haukeland university hospital and the municipality of bergen. the product were developed to prevent malnutrition in the elderly and patients with a low food intake and high energy requirements. the overall contribution to this study will be to provide new insight on how to offer malnourished patients the best available treatment.

Eligibility criteria:
inclusion criteria: * recipients of homecare services in the municipality of bergen * recipients determined as at-risk of malnutrition based on screening with mna (mini-nutritional assessment) * informed consent by participant * informed consent by participants and close relatives or guardian in case of dementia exclusion criteria: * terminal care patients with \< 3 month life expectancy * patients using parenteral or enteral nutrition * patients prescribed oral nutritional supplementation before recruitment * pregnancy * diabetes mellitus * lactose intolerance * patients without a norwegian personal identification number * psychiatric patients

Keywords: malnutrition
telbivudine renoprotective effect in patients with hbv-related liver cirrhosis

Conditions: HBV-related Liver Cirrhosis

Summary: • to estimate renoprotective efficacy of telbivudine treated patients with hbv-related liver cirrhosis.


Eligibility criteria:
inclusion criteria: subjects eligible for enrolment in the study must meet all of the following criteria: * aged between 18-75 years (inclusive). * male or female. * subjects with positive hbsag for more than 6 months and anti-hbs negative regardless of hbeag status , hbv dna ≥2×103 iu/ml * subjects with hbv-related liver cirrhosis, including compensated cirrhosis and decompensated, but only child-pugh a or b. * the ablility to understand and sign a written informed consent prior to any study related procedure and comply with the requirements of the study. exclusion criteria: * subjects meeting any of the following criteria must not be enrolled in the study * subjects with non-hbv cirrhosis * co-infection with hav/hcv/hdv/ hiv * subjects who take nucleosides within 6 months * kidney injury due to non-hbv factors * inability to comply with study requirements as determined by the study investigator * patients with very low gfr, who may need dialysis or renal transplantation

Keywords: tebivudine egfr non-tebivudine
role of vacuum assisted closure (vac) device in postoperative management of pelvic and acetabular fractures

Conditions: Pelvic Fractures; Acetabular Fractures; Hip Fractures

Summary: the purpose of this research is to study the efficacy and cost effectiveness of the vac device in comparison to traditional gauze wound dressing in pelvic, acetabular and hip fractures, specifically to see if there is a reduction in the incidence of post operative surgical wound drainage, infections, and hospital stay.

soft tissue injuries are commonly associated with pelvic and acetabular injuries and additional tissue injury occurs during surgery. post operative wound drainage, infections and prolonged hospital stay are a common problem during postoperative care. traditional treatment is dressing of the surgical wound with different conventional dressings. use of negative pressure wound therapy has been shown to be beneficial in significantly decreasing wound drainage. stannard et al. reported the results of randomizing 44 patients with lower extremity fractures (including 4 pilon fractures) into either receiving standard post operative dressing versus npwt (negative pressure wound therapy). his results showed no difference in infection rate or wound breakdown, but did show a significant difference in the drainage time. the npwt group stopped draining 3 days earlier than the standard dressing group. the use of npwt has greatly increased over the years and has been an important adjunct to wound management. these results and anecdotal clinical experience with the use of npwt (wound vac) has led us to develop our research question; does the use of incisional vac following pelvic \&/or acetabular surgery decrease wound complications. the vac (kci usa) device is relatively new device that utilizes negative pressure as a treatment modality for soft tissue injuries following high velocity injuries. vac device exerts intermittent or constant negative pressure and removes excess fluid from the interstitial space and increases perfusion through vessels. previous vac studies showed decreased bacterial load after applying vac device to the infected wounds. there have been no randomized studies to prove the cost effectiveness and efficacy of vac device in reducing wound drainage, infections, and prolonged hospital stays in comparison to traditional gauze dressing wound management during post operative management of pelvic and acetabular fractures. in examining the incidence of wound complications/infections, we can determine if the incisional vac decreases the need for additional intervention and if there are any patient related factors (i.e. obesity) related to increased risk of wound complications.

Eligibility criteria:
inclusion criteria: * 18 years or older * scheduled for surgical repair of pelvic and/or acetabular fracture * subject/guardian able to provide informed consent exclusion criteria: * less than 18 years of age * subject/guardian unable to provide informed consent

Keywords: fractures pelvic bones acetabulum hip bones