Kornimate/medical-research-clean huggingface dataset:
study of the repair of flexor tendons of the hand

Conditions: Tendon Injury - Hand

Summary: injury to the flexor tendons of the fingers of the hand is a frequent and disabling injury, since it produces tendon retraction and functional limitation. a prompt and adequate diagnosis and treatment is required to minimize the risk of tendon retraction, re-rupture, reoperation rate, and the presence of tendon adhesions that limit the range of motion. on occasions, the limitation of the articular balance of the mcp, pip and dip joints generates a loss of strength and difficult in completely closing the fingers to the palm of the hand.

to retrospectively evaluate the results obtained with the suture/ reinsertion of the flexor tendons of the hand, in the acute, subacute and chronic phases, treated surgically in our center between the years 2000 and 2021. to evaluate the clinical and functional results obtained in patients who underwent surgery for a section of the flexor tendons, superficial, profundus or both, preferably in zone ii of the hand. the investigators evaluate the epidemiological and prognostic factors associated with the injury, in the different phases and anatomical zones. the researchers evaluate the functional results: pain at rest with movements: assessed using the visual analogue pain scale (vas scale from 0 to 10). joint balance / range of motion of the mcp, pip, dip joints. evaluation by digital goniometer. evaluation using buck-gramcko (1976) and using the tang (2007) criteria. grip strength. evaluation using a jamar dynamometer. functional rating scales: quickdash score reoperation rate: 1) for re-rupture / re-suture, 2) for infection, 3) for excision of tendon adhesions: arthrolysis and tendolysis, 4) for tendon transfer 5) for tendon graft placement.

Eligibility criteria:
inclusion criteria: * patients with section of the superficial and / or profundus flexor tendons in the hand. * patients with section of the flexor tendon in the thumb * tendon injury in any anatomical area * in the acute, subacute or chronic phases of the disease * associated or not with fractures * associated or not with arterial or nerve injuries exclusion criteria: * previous bone disease * history of tendon injury to the extensor or flexor tendons * joint stiffness prior to tendon section * rheumatic arthropathy * history of operations in the same area.

Keywords: tendon, flexor, hand
living with fibromyalgia: triggers,subgroups, and a cognitive-behavioral and interactive technology-based intervention

Conditions: Fibromyalgia

Summary: the purpose of this study is to conduct semi-structured qualitative interviews to examine the personal experiences of women living with fibromyalgia. the specific aims of this study are to identify clinically relevant "triggers" of fibromyalgia symptoms and examine their impact on activity limitations and participation restrictions.

fibromyalgia (fm) may currently be the most common rheumatic diagnosis of rheumatologists among their female patients, with 15-20% of all new rheumatology referrals meeting the 1990 american college of rheumatology (acr) diagnosis criteria for fibromyalgia. people with fibromyalgia live through widespread musculoskeletal chronic pain, fatigue, psychological distress, and exhibit diminished physical performance due in part to the cycle of pain that adversely affect their activity participation and overall well-being. the purpose of this prospective mixed methods study is to conduct semi-structured qualitative interviews using ethnographic techniques to examine the personal experiences of women living with fibromyalgia. the specific aims of this study are to identify clinically relevant "triggers" of fibromyalgia symptoms and examine their impact on activity limitations and participation restrictions.

Eligibility criteria:
inclusion criteria: (1)at least 18 years of age; (2) meet the american college of rheumatology (acr) criteria for fm as diagnosed by a physician; (3) have been diagnosed with fm at least 1 year prior to admission to the study; (4) have sufficient vision, based on a functional vision test (i.e., read newsprint) to operate a computer program; (5) speak english; and (6) have a private telephone line. exclusion criteria: (1)living beyond a 40-mile radius from the oakland campus of the university of pittsburgh. (2)disability in everyday tasks related to a diagnosis other than fm (e.g., stroke, parkinson disease) will also be grounds for exclusion.

Keywords: qualitative interview symptom triggers activity and participation
evaluation of fats on postprandial glucose control

Conditions: Type 1 Diabetes

Summary: the purpose of this study is examine the effect of different fat types on postprandial glucose control in patients with type 1 diabetes. subjects will have several admissions and, in random order, will receive lunches with identical carbohydrate content but different fat content: lunch a will minimal fat content, lunch b will contain added butter, lunch c will contain added olive oil, and lunch d will contain added cheese. total fat content in lunches b-d will be the same. subjects will receive identical insulin doses (calculated using the subject's usual insulin-to-carbohydrate ratio) for the meals. the investigators hypothesize that, despite identical carbohydrate content,the lunches higher in saturated fat will lead to more postprandial hyperglycemia than the lunch containing minimal fat and the lunch high in monounsaturated fat. the hypothesis is that from time points 0-180 minute area under the curve for lunches a, b, c, and d will be the same, whereas from time points 180-360 minutes for lunch b and d will be greater than that of lunch a and c.

subjects for this study will be adults with type 1 diabetes who use insulin pump in their diabetes self-management. prior to admission the the clinical research center the basal rates and insulin-to-carbohydrate ratio of the subjects will be optimized using standard clinical procedures. subjects will be admitted to the clinical research center in mid-morning following a light breakfast at home. subjects will have several admissions and, in random order, will receive lunches with identical carbohydrate content but different fat content: lunch a will minimal fat content, lunch b will contain added butter, lunch c will contain added olive oil, and lunch d will contain added cheese. total fat content in lunches b-d will be the same. subjects will receive identical insulin doses (calculated using the subject's usual insulin-to-carbohydrate ratio) for the meals. blood samples for measurement of plasma glucose and insulin levels will be drawn for the subsequent 6 hours. we hypothesize that postprandial glucose levels 3-6 hours after start of the meal will be higher following lunches b and d, compared to lunches a and c.

Eligibility criteria:
inclusion criteria: * adult patients (aged 18-75 years) with type 1 diabetes \> 3 years. * on insulin pump therapy. * a1c \< 8.5%. exclusion criteria: * history or symptoms suggestive of gastric dysmotility, celiac disease, pancreatic exocrine dysfunction or other conditions that cause malabsorption or maldigestion. * eating disorder. * diet allergies. * special diet restrictions, such as vegan or any nut allergy. * medications know to affect insulin sensitivity (such as glucocorticoids) or affect gastrointestinal motility (such as reglan). * high-titre insulin autoantibodies with delayed insulin kinetics. * women who are breast feeding, pregnant, or wanting to become pregnant.
hydrodissection in carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: compare the efficacy on carpal tunnel syndrome (cts) treatment between hydrodissection with hyaluronic acid (ha) vs 5% dextrose

compare the efficacy on carpal tunnel syndrome treatment between hydrodissection with hyaluronic acid vs 5% dextrose through ultrasonographic evaluation.; 2) evaluate the association of median nerve gliding results between using duplex doppler ultrasound and b mode video with cross-correlation algorithm.

Eligibility criteria:
inclusion criteria: * 20-80 years old patients with carpal tunnel syndrome exclusion criteria: * pregnancy, diabetes, hypothyroidism, uremia, rheumatoid arthritis, coagulopathy, cervical radiculopathy and patients who has ever received surgery for carpal tunnel syndrome or wrist fracture

Keywords: carpal tunnel syndrome hydrodissection ultrasonography median nerve gliding
effects of the spinal manipulative therapy and myofascial release in individuals with non-specific chronic low back pain

Conditions: Chronic Low Back Pain

Summary: the aim will be to compare a experimental group submitted to a protocol of spinal manipulation and myofascial release; and a control group composed by spinal manipulation only, in individuals with chronic non-specific low back pain. this is a randomized controlled trial, characterized by the application of manual therapy, in two modalities: spinal manipulation plus myofascial release and spinal manipulation alone. participants will be enrolled and randomly allocated into two groups: 1) spinal manipulation plus myofascial release, totaling 6 sessions, 2x/week, for 3 weeks; 2) spinal manipulation: 6 sessions, 2x/week, for 3 weeks. participants will be evaluated in two different moments: 1) baseline (pre-intervention); 2) at the end of intervention period (3 weeks); and 3) after 3 months follow-up. the primary outcomes will be pain intensity (measured in centimeters with the visual analogue scale - vas) and disability (measured by the quebec questionnaire - qds). the secondary outcomes will be muscle fatigue (measured by the biering-sorensen test), postural balance (measured by the y balance test), pain threshold (algometry, in kgf) and perception of recovery (likert scale of 6-points) and health status (measured by the eq5d3l questionnaire). data analysis will be performed with the spss (statistical package for the social sciences) software version 24.0. data normality assumptions will be confirmed by the shapiro wilk test. if the assumptions were met, a mixed anova with repeated measures will be adopted, based on the outcomes and the independent variables (groups), for the comparison between pre-intervention and post-intervention. spinal manipulation plus myofascial release is expected to have better effects than spinal manipulation alone, associated with the outcomes of interest.


Eligibility criteria:
inclusion criteria: * presence of non-specific chronic low back pain for more than 12 consecutive weeks; * have not performed physical therapy, osteopathic and/or chiropractic sessions for at least 3 months prior to the research. exclusion criteria: * history of trauma or fractures in the trunk and lumbar spine; * presence of neural root symptoms; * infection and inflammation on spine and upper and lower limbs for at least 3 months prior to research; * have undergone surgery on spine, chest and abdomen; * rheumatologic and myopathic diseases; * renal, digestion and neurological diseases; * use of anti-inflammatories drugs and analgesic drugs for at least 2 weeks prior the research.

Keywords: spinal manipulative therapy myofascial release low back pain
preconditioning of tumor, tumor microenvironment and the immune system to immunotherapy

Conditions: Immunotherapy

Summary: promit is a single arm phase 2 trial evaluating the clinical activity of immune checkpoint blockade (icb) after administration of dacarbazine (dtic) in patients with unresectable or metastatic, braf wildtype melanoma with primary resistance to anti-programmed-cell-death-1 (pd-1/pd-l1) or pd-1 plus anti-cytotoxic-t-lymphocyte antigen 4 (ctla-4) blockade therapy. if the activity is clinically meaningful, dtic could become a new therapeutic option to break primary resistance to immunotherapy.

promit is a phase 2, single arm, open label study of dtic followed by combined immune checkpoint blockade (icb) therapy or pd-1/pd-l1-blockade monotherapy in adult (≥ 18 years) subjects with previously treated, unresectable or metastatic melanoma (stage iii or stage iv melanoma as per the ajcc staging system). subjects must be braf wildtype and must have shown primary resistance to icb. fresh tumor tissue from an unresectable or metastatic site of disease must be available. subjects will be treated with dtic 850 mg/m² day 1 and 21 i.v. (dtic phase). afterwards, patients will receive combined ipilimumab (3 mg/kg) and nivolumab (1 mg/kg) 4 times every 3 weeks i.v. or nivolumab 240 mg every 2 weeks or pembrolizumab 200 mg every 3 weeks (icb re-exposure phase; ema-approved dosing scheme). by the end of the icb phase, response will be documented (primary endpoint). a safety follow-up for treatment-related adverse events will be performed until 30 days after the last dose of combined icb. patients will be followed for survival every 12 weeks after the end of the combined icb phase (second primary endpoint). tumor and blood samples will be assessed over the course of the study to evaluate changes in tumor, tumor microenvironment and immune system.

Eligibility criteria:
inclusion criteria: 1. histologically confirmed metastatic melanoma 2. progression after checkpoint inhibitor therapy (pd-1/pd-l1 or pd-1 + ctla-4 blockade) 3. accessible tumor metastases 4. ecog 0 or 1 5. adequate organ function exclusion criteria: 1. uvea melanoma, mucosal melanoma 2. previous chemotherapy in metastatic disease 3. previous response to checkpoint inhibitor therapy (pd-1/pd-l1 or pd-1 + ctla-4 blockade) in metastatic disease 4. braf v600 mutation 5. active brain metastases 6. autoimmune disease requiring more than 10 mg prednisolone daily or other immunosuppressive drugs

Keywords: immune checkpoint blockade resistance dacarbazine
super skills for life effectiveness in the online modality

Conditions: Depressive Disorder; Depressive Symptoms; Anxiety Disorders; Anxiety Disorders and Symptoms; Mood Disorders; Child Mental Disorder; Emotional Disorder

Summary: the study aims to evaluate the effectiveness of the transdiagnostic program super skills for life (ssl). this protocol targets children aged 8 to 12 with emotional problems (anxiety, depression, low self-esteem, and lack of social skills). ssl consists of eight sessions targeting common risk factors for internalizing disorders such as cognitive distortions, avoidance, emotional management, low self-esteem, social skills deficits, and coping strategies. the present research focuses on assessing the effectiveness of ssl applied online (through a virtual platform).

after selecting the children based on the online questionnaires completed by the parents (preintervention assessment) and inclusion/exclusion criteria, they were randomly allocated to the conditions of the intervention group and the wait-list control group. parents and children from both groups completed the same measures at baseline, post-treatment, and 12 months follow-up. children in the experimental group received the ssl program by the virtual platform. the objective of the study is to evaluate the benefits of the super skills for life protocol applied online. for this purpose, the researchers will test to what extent the experimental group decreases its anxiety symptoms, anxiety impairment, depressive symptoms, behavioral problems, hyperactivity/inattention, and peer relationship problems, and increase its self-esteem and prosocial behaviors, compared to the control group. in conclusion, the purpose of the study is to explore whether ssl implemented online can be a cost-effective psychological intervention to prevent emotional problems in spanish children.

Eligibility criteria:
inclusion criteria: * children aged 8-12 * presenting subclinical symptoms of emotional problems (anxiety, depression) * speaking, reading, writing, and understanding spanish. * not receiving psychological or pharmacological treatment for emotional and/or behavioral problems exclusion criteria: * had a psychiatric diagnosis already established * presenting a severe developmental disorder (intellectual disability, autism spectrum disorder, etc).

Keywords: super skills for life emotional problems internalizing problems children anxiety depression
study of gdc-0980 versus everolimus in participants with metastatic renal cell carcinoma who have progressed on or following vascular endothelial growth factor- (vegf) targeted therapy

Conditions: Renal Cell Carcinoma

Summary: study pim4973g is a multicenter, international, open-label phase ii trial. participants with metastatic renal cell carcinoma who have progressed on or after vegf targeted therapy will be randomized in 1:1 to two groups either to receive daily gdc-0980 or everolimus orally.


Eligibility criteria:
inclusion criteria: * histologically or cytologically documented, incurable metastatic renal cell carcinoma with clear-cell component that progressed on or within 6 months of stopping vegf-targeted therapy * disease that is measurable per response evaluation criteria in solid tumors version 1.1 (recist v1.1) * karnofsky performance status of greater than or equal to (\>=) 70 percent (%) * adequate hematologic and end organ function * for female participants of childbearing potential and male participants with partners of childbearing potential, agreement to use two effective forms of contraception and to continue its use for the duration of the study exclusion criteria: * any anti-cancer therapy, including chemotherapy, biologic or other targeted therapy, herbal therapy, hormonal therapy, or radiotherapy, within 5 half-lives (for systemic agents) or 2 weeks, whichever is shorter, prior to day 1. certain forms of radiation therapy may be considered for pain palliation if participants are deriving benefit * previously established diagnosis of pulmonary fibrosis of any cause * new york heart association (nyha) class ii or greater congestive heart failure * history of malabsorption syndrome or other condition that would interfere with enteral absorption * presence of positive test results for hepatitis b (hepatitis b \[hb\] surface antigen \[hbsag\] and/or total hb core antibody \[anti-hb-c; both tests are required\]) or hepatitis c * known human immunodeficiency virus (hiv) infection * pregnancy, lactation, or breastfeeding * major surgical procedure or significant traumatic injury within 28 days prior to day 1 or anticipation of the need for major surgery during the course of study treatment * leptomeningeal disease as a manifestation of cancer * history of other malignancies less than equal to \<= 5 years of day 1 except for tumors with a negligible risk for metastasis or death, such as adequately controlled basal cell carcinoma or squamous cell carcinoma of the skin or carcinoma in situ of the cervix * need for current chronic corticosteroid therapy (\>= 10 milligrams \[mg\] of prednisone per day or an equivalent dose of other anti-inflammatory corticosteroids for greater than \[\>\] 7 days) or use of other immunosuppressant
olfactory dysfunction of rhinosinusitis - cyclic adenosine monophosphate (camp)/calcium signaling study

Conditions: Sinusitis

Summary: the study examines the biochemistry underlying human olfaction in both normal and diseased states. the study aims are: 1. to determine the levels of camp in olfactory tissue from people with chronic rhinosinusitis and other nasal disorders. 2. to correlate preoperative olfactory function with camp levels from biopsied olfactory tissue. 3. to determine odorant and pheromone-mediated activation of cultured human olfactory sensory neurons using calcium imaging and 4. to determine odorant and pheromone-mediated activation of cultured human olfactory sensory neurons using "smell-chip" technology.

subject will be recruited from those scheduled to have endoscopic sinus surgery and similar procedures. this study uses the tissue that would normally be discarded during the surgical process. the tissue is cultured and frozen for purposes of the following testing: odor detection and signal transduction, cyclic adenosine monophosphate and odor detection, the role of camp in olfactory dysfunction, and pheromone detection. only tissue that would normally be discarded during the course of the surgery will be used. the study does not interfere with or change any clinical care.

Eligibility criteria:
inclusion criteria: * subjects will be 18 years old and over and scheduled for one of the following: * endoscopic sinus surgery for chronic sinusitis * endoscopic transnasal approach to the pituitary for pituitary tumor removal * endoscopic inferior turbinectomy or septoplasty for nasal congestion * endoscopic repair of cerebrospinal fluid (csf) leaks exclusion criteria: * subjects are excluded if they are unable to give informed consent or unable to complete self-administered questionnaires due to english language barrier, cognitive impairment, or severe medical conditions

Keywords: sinusitis
hypospadias and exome: identification of new genes for familial hypospadias

Conditions: Hypospadias

Summary: hypospadias is the second most common malformation of the male genitalia and consists in a congenital hypoplasia of its ventral face. hypospadias results from abnormal development of the penis that leaves the urethral meatus proximal to its normal glanular position. meatus position may be located anywhere along the penile shaft, but more severe forms of hypospadias may have a urethral meatus located at the scrotum or perineum. glandular and penile anterior represents approximately 70% of all the diagnosed cases. the frequency of family reached depend on the severity of hypospadias. the number of children which have hypospadias mutation discovered by classical technique is low. families are often the cause of the discovery of new genes involved in sexual differentiation because they allow comparison of genomes of related persons, and detect more easily mutations.

the aim of this protocol is to search for new genes involved in genital malformations such as hypospadias. addressed to families with usual causes of these malformations excluded. the search for these mutations will be done by exome sequencing in families where several cases of hypospadias were identified.

Eligibility criteria:
inclusion criteria: * hypospadiac patients with a familial history of hypospadias exclusion criteria: * hypospadiac patients without a family history of hypospadias * hypospadiac patients with a family history of hypospadias where etiology is identified

Keywords: hypospadias exome sequencing genital malformation
the psychological interventions for alleviating anxiety and depressive emotion among oocyte retrieval patients

Conditions: Infertility; in Vitro Fertilization; Mental Health; Anesthesia, General

Summary: the goal of this clinical trial is to learn if psychological interventions alleviate the anxious emotion of women undergoing oocyte retrieval operation with general anesthesia. the main questions it aims to answer are: if psychological interventions reduced participants' anxiety scores before the oocyte retrieval operation. researchers will compare psychological interventions to no interventions to see if psychological interventions work to alleviate anxious emotion. questionnaires related anxiety were completed online before surgery by participants.


Eligibility criteria:
inclusion criteria: * underwent oocyte retrieval operation with general anesthesia * able to use smartphone to complete questionnaire exclusion criteria: * had major psychological trauma, schizophrenia * morbid obesity (bmi greater than 40.0 kg/m2.) * serious disease of cardiovascular system including uncontrolled hypertension * serious endocrine system disease including uncontrolled hypothyroidism * history of severe adverse events related to anesthesia * history of substance abuse or severe allergy * refusal to provide written consent

Keywords: oocyte retrieval anxiety symptoms depression symptoms psychological intervention intravenous anesthesia