Kornimate/medical-research-clean huggingface dataset:
evaluation of zinc in patients with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: investigation of the impact of zinc level on the development of dm and to elaborate on whether daily consumption of zinc affects the disease's evolution.

the relationship between the pathophysiology of diabetes mellitus and trace element dysregulation emphasizes how crucial it is to maintain appropriate micronutrient status in order to manage this chronic metabolic disease. one promising strategy for enhancing glycemic control and lowering the risk of diabetic complications may be to address these underlying dietary imbalances. accordingly, the aim is to investigate the impact of zinc level on the development of dm and to elaborate on whether daily consumption of zinc affects the disease's evolution.

Eligibility criteria:
inclusion criteria: * confirmed type 2 dm with no known complication * more than or equal 40 years old exclusion criteria: pregnancy and lactation type 1dm known dm complication other endocrinological disorders malignancy

Keywords: type 2 dm, zinc
effectiveness and safety of mmscs for enhancing hematopoietic recovery and prophylaxis of neutropenic enterocolitis

Conditions: Neutropenic Enterocolitis; Myeloablative Chemotherapy Induced Bone Marrow Aplasia

Summary: subjects will undergo peripheral blood stem cell mobilisation and collection with subsequent high-dose chemotherapy. after finalization of high-dose chemotherapy subjects will receive bone marrow derived allogeneic multipotent mesenchymal stromal cells intravenous infusion two hours prior to autologous peripheral blood cells infusion. this is a single arm study with no control. all patients receive cell therapy.

patients with verified diagnosis hodgkin's lymphoma or non-hodgkin's lymphoma will undergo peripheral blood stem cell mobilisation and collection (chemotherapy + g-csf or g-csf+plerixafor). after that high-dose chemotherapy will be performed according to protocols ice and beam (standard scheme). patient will receive bone marrow derived allogeneic multipotent mesenchymal stromal cells infusion 48 hours after last administration of cytotoxic agent . number of cells calculated according to patient's body weight (1,5-2,0 mln of cells/kg), time of infusion - 30 minutes. two hours later patient will receive autologous peripheral blood cells infusion.

Eligibility criteria:
inclusion criteria: * patient suffers from hodgkin's lymphoma, non-hodgkin's lymphoma with complete or partial remission. * patient is candidate to high-dose chemotherapy with subsequent autologous hematopoietic stem cell transplantation. * absence of infection, cardiovascular, respiratory, renal and hepatic dysfunctions, focal neurological symptoms. * karnofsky score at least 70. * patient successfully undergone mobilization of peripheral blood stem cells. * patient is familiar with participant information sheet. * patient signed informed consent form. non-inclusion criteria: * severe chronic comorbidity with symptoms of organ or system failure. * significant abnormalities in laboratory tests. * participation in other clinical trials (or intake of study drugs) within prior 3 months. * conditions restricting commitment to participating in the trial (dementia, neuropsychiatric disorders, drug and alcohol abuse) * patients with malignant solid tumors. * patients with medical history of heterotopic ossification. exclusion criteria: * progression or relapse of lymphoma during therapy. * confirmed syphilis, hiv, hepatitis b or c infection * absence of clinical and laboratory signs of hematopoietic recovery and persistent enterocolitis at day 14 after the manipulation (visit 15). while the patient remains in the hospital and continues treatment according to requirements of standard therapy

Keywords: hodgkin lymphoma non-hodgkin's lymphomas allogeneic mesenchymal stem cell transplantation autologous peripheral blood stem cell transplantation neutropenic enterocolitis myeloablative chemotherapy bone marrow aplasia
radiation induced cystitis treated with hyperbaric oxygen - a randomized controlled trial

Conditions: Cystitis, Radio Induced

Summary: the primary objective of this study is to assess the relief of symptoms after hyperbaric oxygen therapy (hbot) in patients with late radiation cystitis by having expanded prostate cancer index composite (epic)symptom estimation scale as primary variable. study hypothesis: * hbot can reduce or reverse the change or otherwise limit the damage of the bladder function and/or structure, which arose as a result of radiation therapy of cancer in the pelvic region organs. * the effects of hbot are associated with relief of symptoms that, at least in part, is related to the reduction of the extent of the radiation damage. * vascular density increases, fibrosis prevalence and inflammatory activity are reduced as a sign of an improved function of the mucosa. * treatment results of hbot remains, in whole or in part, during the follow-up (residual effect)

radiotherapy is commonly used in the management of malignant diseases. despite a continuous improvement of the technique, with improved efficacy and tolerance, adverse effects are still rather common. the urinary bladder and rectum are the major organs most commonly affected by radiotherapy to the pelvis area. one of the most significant causes of the symptoms of radio therapy is inflammation and degeneration of blood vessels in the radiated tissue. hyperbaric oxygen therapy involves administration of oxygen at greater than normal atmospheric pressures. a well-documented effect of hbot is the stimulation of angiogenesis. hbot is an established treatment for degeneration of blood vessels in the jaw bone as a result of radiotherapy and several publications have shown good efficacy also when soft tissue is affected. if the method of treatment with hbot means a reduction of the radiotherapy side effect it is thus an obvious importance for the individual patient. there is also significant potential savings for the healthcare and society.

Eligibility criteria:
inclusion criteria: * provision of informed consent prior to any study specific procedures * female or male aged 18-80 years * intended curative radiation of the pelvic region as a treatment for cancer * end of radiation therapy more than 6 months ago * radiation cystitis with urological epic \< 80 * radiation cystitis is the most probable cause for the patient's symptoms exclusion criteria: * patients with major and ongoing bleedings from the bladder (requiring more than 0.5l blood-transfusion within the last four weeks) * refractory incontinence requiring catheter or surgical intervention * urine bladder capacity \< 100ml * fistula in the urine bladder * contraindications for hbot according to the local centres routines * pregnancy * mechanical ventilator support * unable to follow and understand simple commands * not oriented to person, place and time

Keywords: radio therapy stri urinary bladder hyperbaric oxygen
endotypic stability in crs

Conditions: Chronic Sinusitis

Summary: a case control study with 150 cases and 50 controls will be conducted. immunologic (cytokines measurements in nasal secretions and sinonasal tissues), histopathologic (tissue eosinophilia) and clinical parameters (lund-mackay and lund-kennedy score, lung function tests), surveys (snot- 22, sf-36 quality of life survey) will be compared between different groups of patients


Eligibility criteria:
inclusion criteria: * patients with chronic sinusitis (with or without polyps) * undergoing endoscopic sinus surgery during the study period * more than 18 years * no chronic illness/ malignancy
long term effect of general practitioner education on antibiotic prescribing

Conditions: Respiratory Tract Infections

Summary: respiratory tract infections are the most common indication for antibiotic prescribing in primary care. several studies have shown a strong relationship between antibiotic use and bacterial resistance. the aim of this trial was to assess the long-term effect of a continuous education program on general practitioners antibiotic prescribing behaviour. 170 physicians were included in this study. physicians randomized in the education group attended a two days seminar focused on evidence-based guidelines on antibiotic use in respiratory tract infections. the intervention was limited at physicians level and did not target the patients.


Eligibility criteria:
inclusion criteria: * general practitioners practicing in three departments of the parisian area in france * general practitioners attending a two days didactic educational meeting on evidence-based guidelines for diagnosis and treatment of acute respiratory tract infection. exclusion criteria: * none

Keywords: antibiotic prescribing behaviour guidelines respiratory tract infections non-antibiotic prescription
aqt90 flex d-dimer clinical sensitivity and specificity

Conditions: VTE (Venous Thromboembolism)

Summary: the goal of this study is evaluate the clinical performance of the aqt90 flex d-dimer test as an aid in the diagnosis of venous thromboembolism.

the objective is to evaluate the clinical performance of the aqt90 flex d-dimer test as an aid in the diagnosis of vte in patients presenting with low or moderate pretest probability (ptp), by determining the clinical sensitivity, specificity, negative predictive value (npv), positive predictive value (ppv), positive likelihood ratio (lr+) and negative likelihood ratio (lr-) of the assay.

Eligibility criteria:
inclusion criteria: * subject is 18 years of age and older * subject, who presents with signs and symptoms of vte and had low or moderate pre-test probability of dvt or pe assessed by well's score * subject must be able to understand information given, and be willing and able to voluntarily give their consent to participate in this study exclusion criteria: * subject, who is pregnant * subject, who has received fibrinolytic therapy within the previous seven days * subject, who has received treatment with anticoagulants (unfractionated heparin, lmwh, vka (vitamin k-antagonists), doacs (direct oral anticoagulants) within the previous seven days * subject, who has had trauma or surgery within the previous four weeks * subject with malignancy * subject with disseminated intravascular coagulation (dic) * subject, who has an invalid written informed consent or has withdrawn consent

Keywords: d-dimer
community interventional trial (citfomist)

Conditions: Vitamin D Deficiency

Summary: the cluster randomized trial (citfomist) was conducted on 15-19-year old guidance and high school students of both genders from different districts of tehran, the iranian capital, in winter 2011. the 36 schools enrolled in this study were randomly assigned to receive one of the three groups of milk -- whole milk, milk that contained 600 iu vit d/1000cc, milk that contained 1000 iu vit d /1000cc -- for a 30-day period. in order to study the effect of vitamin d-fortified milk on the circulating concentrations of 25(oh)d, a serum vitamin d levels were checked in a subgroup before and after the intervention.

the cluster randomized trial (citfomist) was conducted on 15-19-year old guidance and high school students of both genders from different districts of tehran, the iranian capital, in winter 2011. the 36 schools enrolled in this study were randomly assigned to receive one of the three groups of milk -- whole milk, milk that contained 600 international unit (iu) vit d/1000cc (120iu), milk that contained 1000 iu vit d /1000cc (200iu)-- for a 30-day period. in order to study the effect of vitamin d-fortified milk on the circulating concentrations of 25(oh)d, a serum vitamin d levels were checked in a subgroup before and after the intervention.

Eligibility criteria:
inclusion criteria: * 15-19-year old guidance and high school students of both genders from different districts of tehran, the iranian capital exclusion criteria: * those taking vitamin d supplements * those with underlying disease affecting bone health * those taking medication affecting bone metabolism * those taking fortified products on a regular basis * those following special diets

Keywords: vitamin d deficiency compliance milk
mbsr program and evaluating its effectiveness on relieving chronic pain in the elderly

Conditions: Chronic Pain

Summary: it has been shown that mbsr could be effective in different types of chronic pain in geriatrics, but more evidence in the interdisciplinary context is needed. this study is conducted to develop and compile a mindfulness-based stress reduction (mbsr) program within a context of physiotherapy rehabilitation to manage chronic pain in the elderly in an iranian clinical setting. the 8-session mbsr treatment protocol was translated, revised for the iranian elderlies, and compiled as a one-on-one therapy using a unique protocol with 20-session physiotherapy. 40 volunteers aged 65 or more with musculoskeletal chronic pain will be selected and receive the program for 8 consecutive weeks with a 3-month follow-up. treatment satisfaction levels, adherence to treatment sessions, and patient-reported clinical outcome measures were used at baseline, immediately post-intervention, and three months following the intervention, measuring pain, anxiety, fatigue, sleep disturbance, pain interference levels, and kinesiophobia.


Eligibility criteria:
inclusion criteria: * aged 65 or more * have chronic pain * have ability of reading and writing in persian * visiting the clinic in which the study was took place exclusion criteria: * dose not have any diagnosed cognitive impairment * failure to approve the consent form

Keywords: mindfulness-based stress reduction program chronic pain elderly physiotherapy
laryngomalacia exposed

Conditions: Complications

Summary: laryngomalacia is the most common congenital laryngeal anomaly and the most frequent cause of stridor in infants and children. symptoms usually appear within the first 2 weeks of life. its severity increases up to 6 months. 15-60% of infants with laryngomalacia have synchronous airway anomalies.

the most common health complications associated with laryngomalacia were: 1. gastroesophageal reflux which was presented by arching, choking, gagging, feeding aversion and continuous crying 2. frequent unilateral eye infections 3. repeated choking, frequent vomiting and poor weight gain 4. repeated upper respiratory tract infections (viral and bacterial), coughing and cyanosis 5. repeated secretory otitis media 6. aspiration pneumonia

Eligibility criteria:
inclusion criteria: * 500 full term babies ≥ 37 weeks of both sexes were delivered by different modes of delivery, with birth weights of ≥ 2.5 kg, with no history of natal complications and from the same community. * mothers of these babies are from different socioeconomic standards with different educational levels.

Keywords: factors predisposing or causing
olanzapine for chemotherapy-induced nausea and vomiting prophylaxis

Conditions: Complete Response Rate to Chemotherapy-induced Nausea and Vomiting Prophylaxis

Summary: to investigate that olanzapine can reduced side effect about nausea and vomiting in women with gynecologic cancers receiving carboplatin-based regimen by using olanzapine and placebo

a double-blind, placebo-controlled, randomized crossover trial

Eligibility criteria:
inclusion criteria: * women with gynecological cancer receiving carboplatin-based chemotherapeutic regimen * ecog performance status 0-1 * normal bone marrow, liver, and renal functions * can speak and write in thai language exclusion criteria: * women with nausea or vomiting prior to chemotherapeutic administration * pregnant women * women with active infection * women with bowel obstruction * women with symptomatic brain metastases * women who received dopamine receptor antagonists within 1 week before chemotherapeutic administration * women who received corticosteroid within 1 week before chemotherapeutic administration * women with past history of chemotherapy or radiotherapy * women with psychiatric disorders * women with poor controlled diabetes mellitus * women who received anticonvulsant medication * women with history of neuroleptic malignant syndrome * women with history of olanzapine allergy * women with history of lactose intolerance

Keywords: olanzapine chemotherapy-induced nausea and vomiting carboplatin gynecologic cancer
effect of topical brimonidine on post cataract surgery corneal edema

Conditions: Corneal Edema; Visual Acuity

Summary: most patients undergoing cataract surgery suffer from corneal edema after the surgery. brimonidine drops are a well known and safe anti-glaucoma medication. the investigators have made several clinical observations that patients receiving brimonidine drops had a faster resolution of their corneal edema even if they had normal intra-ocular pressure. the investigators believe that administering topical brimonidine to patients with significant post operative corneal edema will hasten the resolution of their corneal edema.

most patients undergoing cataract surgery suffer from corneal edema after the surgery which temporarily reduces their visual acuity until corneal edema resolves over several weeks brimonidine drops are a well known and safe anti-glaucoma medication, used to lower intra ocular pressure. there have been several clinical observations that patients receiving brimonidine drops had a faster resolution of their corneal edema even in the presence of normal intra-ocular pressure. the investigators postulated that administering topical brimonidine to patients with significant post operative corneal edema will hasten their recovery and visual improvement. in order to prove that brimonidine drops contribute to faster resolution of cornel edema and visual improvement, the study will randomly compare 50 post cataract surgery patients (group a)who will be administered brimonidine to 2 control groups (50 people in each group): group b will be given topical timolol drops 0.5% (another well recognized anti glaucoma medication which reduces intra-ocular pressure by different mechanism than brimonidine. group c will not be given any test drug. all 3 groups will receive the regular post operative medications which include corticosteroids and antibiotics.

Eligibility criteria:
inclusion criteria: * 1 day after uneventful cataract surgery * corneal edema (grade 2 to 3) exclusion criteria: * glaucoma * higher than normal intraocular pressure (\>23 mm hg) * known sensitivity or contra indication to brimonidine * known sensitivity or contra indication to timolol * pre operative corneal or anterior segment disease * intraoperative complications * major ocular pathology other than corneal that reduced vision (retinal degeneration, optic neuropathy etc.) * pregnant women * children

Keywords: corneal edema postoperative corneal edema central corneal thickness visual acuity postoperative brimonidine timolol cataract surgery
autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (me/cfs)

Conditions: Myalgic Encephalomyelitis; Chronic Fatigue Syndrome

Summary: this study investigates whether there is an immune response directed against gut microbes or food and parts of the body in severe myalgic encephalomyelitis/chronic fatigue syndrome (me/cfs) patients.

severe myalgic encephalomyelitis/chronic fatigue syndrome (me/cfs) patients will be identified by epsom and st helier cfs service and the clinical research network eastern. information sheets will be posted by health professionals to eligible patients. interested patients are asked to arrange a telephone call with the research team to receive more information about the study. volunteers still interested after the 72 hour consideration period arrange a home visit to be taken through the consenting process. household controls will be recruited through patients participating in the study. patients invited will be provided with information about household controls. the patient identifies and informs potential household controls of the study using information sheets provided by their health professional. household controls willing to participate in the study will be taken through an eligibility questionnaire with gcp trained researchers. six stool and blood samples will be collected over the three year study period. stool and blood samples need to be collected within 24 hours of each other, during home visits. 48 hour food diaries will be completed prior to each stool sample collection. the study is based at the quadram institute and the university of east anglia (uea). the research is funded by the uea and invest in me research uk.

Eligibility criteria:
inclusion criteria: * severe me/cfs patients: men or women aged 18 to 70 years with a clinical diagnosis of severe me/cfs patients * household controls: men or women aged 18 to 70 years, no current or on-going medical conditions. has to be either related/non-related, living in the same household or in close proximity to, or providing care to the severe me/cfs patient they are paired with. exclusion criteria: * severe me/cfs patients: the presence of significant anxiety or depression. have received probiotics or antibiotics up to six weeks before joining the study. * household controls: the presence of long term medical conditions, in particular, affecting the stomach or bowel. previously diagnosed with autoimmune diseases, for example, systemic lupus erythematous or rheumatoid arthritis. suffer from significant anxiety or depression. in recipient of immunomodulatory drugs, statins, beta blocker or steroids. have received probiotics or antibiotics up to six weeks before joining the study.
study of blood parameters of the malnourished children: before and after giving nutritional biscuit's treatment

Conditions: Undernutrition

Summary: present study was designed to evaluate the efficacy of the nutritional intervention, in the sam (severe acute malnutrition)children by monitoring various anthropometric,biochemical ,hormonal and enzymatic parameters before and after the nutritional intervention treatment.this study was also intended to study possible functional role of gene hri (heme regulated inhibitor) as a molecular marker for the early detection of iron deficiency anemia in malnourished children similarly present study has also tried to find anthropometric marker and different correlations among study parameters.

in india, child malnutrition is responsible for 22% of the country's burden of disease. development of local therapeutic nutritional intervention is highly recommended by who. present study was designed to evaluate the efficacy of the nutritional intervention, as well as to study hri (heme regulated inhibitor) gene expression, to suggest it as a molecular marker for the early detection of iron deficiency anemia in malnourished children also to find anthropometric marker and different correlations of study parameters. 105 test and 100 control sam (severe acute malnutrition) children without infection, of 1 to 5 years of age and either sex were enrolled. test group was given treatment of nutritional intervention therapy (nit), providing 2.5 to 3gm protein and 90-100kcal/kg body weight/day, for the three months period. their anthropometric, enzymatic, biochemical and hormonal parameters were measured before and after the nit. correlation of serum triglyceride with weight for height% , as well as correlation of hri with mean corpuscular hemoglobin,(mch) was studied. similarly status of hairs, skin, oedema, who z- score,and bmr was also studied before and after the nit.

Eligibility criteria:
inclusion criteria: * subjects from age group of 1 to 5 years of either sex belonging to sam (severe acute malnutrition) category and provided therapeutic nutritional biscuit's treatment. * subjects from age group of 1 to 5 years of either sex belonging to sam and not taking nutritional biscuit's treatment, included as a control for comparative study. exclusion criteria: * children above 5 years of either sex. * sam children with various infections.

Keywords: nutritional intervention iron deficiency anemia