Kornimate/medical-research-clean huggingface dataset:
study of colchicine to treat and prevent recurrent pericarditis after failure of conventional treatment.

Conditions: Pericarditis; Recurrence

Summary: the purpose of the study is to determine whether colchicine is safe and effective in treatment and prevention of recurrent pericarditis after failure of conventional treatment.

colchicine is safe and effective in the management of recurrent pericarditis after failure of conventional treatment. preliminary data (observational, non-randomized studies without a control group) have shown that the drug may be effective in treatment of the second and subsequent recurrence and the prevention of further recurrences.

Eligibility criteria:
inclusion criteria: * patients with the second and subsequent attack of recurrent pericarditis, * age≥ 18 years, * informed consent. exclusion criteria: * suspected neoplastic, tuberculous, or purulent etiology, * known severe liver disease and/or elevated transaminases \>1.5 times the upper limit of normality, * serum creatinine\>2.5 mg/dl, * serum ck over the upper limit of normality or known myopathy, * known gastrointestinal or blood disease, * pregnant or lactating women or women not protected by a contraception method, * known hypersensibility to colchicine, * treatment with colchicine at the enrolment.

Keywords: pericarditis recurrence therapeutics prevention colchicine
understanding the role of dietary fatty acids on liver fat metabolism in humans

Conditions: NAFLD

Summary: high levels of fatty substances in the blood increase the risk of developing heart disease. investigators know a lot about one of these fatty substances, cholesterol. however, there is another fatty substance in the blood called triglyceride. investigators do not understand much about what regulates the rate at which the liver produces triglyceride and liberates it into the bloodstream after eating a meal(s). it is known that taking fish oil lowers the amount of blood triglyceride however, it remains unclear how this happens. investigators will study if changes in liver fat metabolism, after taking fatty acids found in fish oil (n-3 fatty acids)can explain the lowering of blood triglyceride. investigators also want to know if taking fish oil alters the amount of fat that accumulates within the liver.

investigators will recruit men and women with no medical condition or relevant drug therapy that affects liver fat metabolism. purpose and design: investigators are asking the research question: "how do specific fatty acids, such as those found in fish ((n-3) fatty acids) influence postprandial liver fat metabolism?" it is known that n-3 fatty acids lower plasma triglyceride concentrations but it remains unclear how this happens. to address this research question investigators want to undertake detail physiological studies, in a randomised study where individuals will be studied before and after taking n-3 fatty acids or a placebo oil.

Eligibility criteria:
inclusion criteria: * participant is willing and able to give informed consent for participation in the study. * bmi \>19 \<35kg/m2 * no medical condition or relevant drug therapy known to affect liver metabolism exclusion criteria: * age \ 65 years * body mass index \ 35kg/m2 * a blood haemoglobin \<120mg/dl * any metabolic condition or relevant drug therapy * people allergic to fish / seafood or nuts * smoking * history of alcoholism or a greater than recommended alcohol intake * pregnant or nursing mothers * women prescribed any contraceptive agent or device including oral contraceptives, hormone replacement therapy (hrt) or who have used these within the last 12 months * history of severe claustrophobia * presence of metallic implants, pacemaker * haemorrhagic disorders * anticoagulant treatment

Keywords: plasma triglycerides dietary fat liver fat metabolism human
efficacy of intralesional sodium thiosulfate versus intralesional saline for dystrophic and idiopathic calcinosis cutis

Conditions: Calcinosis Cutis

Summary: the purpose of our research is to compare the effectiveness of 125mg/50ml sodium thiosulfate (sts) solution to normal saline (0.9% sodium chloride) when injected intralesionally for the treatment of calcinosis cutis. our specific aim is to assess the response of dystrophic and idiopathic calcinosis cutis to the injections of sodium thiosulfate in our patients.

our specific aim is to assess the response of dystrophic and idiopathic calcinosis cutis to the injections of sodium thiosulfate in our patients.

Eligibility criteria:
inclusion criteria: * male or female adult 18 years of age or older * must have health insurance will be eligible to participate * must have a current diagnosis of dystrophic or idiopathic calcinosis cutis * subjects must have at least 2 lesions of at least 2mm in size exclusion criteria: * unable to read and speak english * allergy to any component of the sodium thiosulfate solution * adults unable to consent * individuals who are not yet adults (infants, children, teenagers) * pregnant women * women who are breastfeeding * prisoners

Keywords: calcinosis cutis sodium thiosulfate sodium chloride
pro 140 by iv administration in adults with hiv-1 infection

Conditions: HIV Infections

Summary: the purpose of this study is: 1. to assess and characterize the pk and pd of pro 140 administered iv 2. to assess the antiviral activity of pro 140 3. to assess the safety and tolerability of pro 140


Eligibility criteria:
inclusion criteria: 1. males \& females, age ≥ 18 years (or minimum adult age as determined by local regulatory authorities) 2. screening plasma hiv-1 rna ≥ 5,000 copies/ml 3. cd4+ t-lymphocyte cell count ≥ 300 cells/mm3 and no documented count \< or = 250 cells/mm3 4. has not taken any anti-retroviral therapy (art) w/in 12 wks of early screening visit 5. exclusive ccr5-tropic virus as determined by trofile™ assay at early screening visit 6. clinically normal or "not clinically significant (ncs)" resting electrocardiogram 7. women of reproductive potential must have a negative serum pregnancy test at late screening visit \& a negative urine pregnancy test w/in 72 hrs prior to first dose of study medication, \& be non-lactating. male \& female subjects must agree not to participate in a conception process from early screening visit through day 59. exclusion criteria: 1. cxcr4 tropic virus or dual/mixed tropic (r5x4) virus determined by the trofile™ assay. 2. females who are pregnant, lactating or breastfeeding, or who plan to become pregnant during the study. 3. history of active hepatitis within the previous 24 wks 4. prior use of any entry, attachment, ccr5 co-receptor or fusion inhibitor, experimental or approved.

Keywords: hiv treatment naïve
laparoscopic versus open partial nephrectomy - surgical and oncological outcomes

Conditions: Tumor; Nephrectomy; Laparoscopy

Summary: partial nephrectomy is the standard care for small (\<4 cm) renal tumors. despite the expanding use of laparoscopic approach, debate exist regarding the short and long term outcomes compared to the open approach. our goal is to perform a prospective randomized trial to compare these methods


Eligibility criteria:
inclusion criteria: * patients referred to partial nephrectomy exclusion criteria: * contra-indication for laparocopic surgery * complexed , large tumors, single kidney, chronic renal failure

Keywords: renal tumor, rcc, partial nephrectomy, laparoscopy
covid-19 in children in niger, 2020

Conditions: to Contribute to a Better Control of COVID-19 in Children in Niger

Summary: on january 30, 2020, the who declared covid-19 a global health emergency. children were affected with less severe forms. niger had implemented measures in a context where children are a source of contamination. the objective was to determine the factors associated with covid-19 in children in niger from february to august 2020 through an analysis of the national database.

we conducted an analytical cross-sectional study including all covid-19 suspects in the database. we used excel and epi info 7.2.4. software for data extraction and analysis. frequencies and proportions were calculated, we estimated in a logistic regression the or of association with their 95% confidence interval, the factors associated with covid-19 at the threshold of p\<0.05. results: of 572 notified suspected covid-19 cases in children aged 0-15 years, 11.36% were positive. the median age of infected children was 10 years \[iqr: 5- 13 years\]. the sex ratio of males to females was 2.1. children aged 11-15 years were 49.2%, 61.5% resided in niamey, 4.6% had comorbidities. the notion of travel was 12.3% and 40% had a notion of contact, 24.4% had a fever, 23.2% had a cough, 18% were hospitalized and the case fatality was 1.5%. in etiological analysis, the factors associated with covid-19 were sex ora= 0.51 \[0.28-0.93\] p=0.028, the presence of symptoms ora= 2.29 \[1.23-4.25\] p=0.008 and the notion of contact ora= 0.32 \[0.13-0.77\] p=0.011. exposed children were sensitive to covid-19, all age groups were affected with a male predominance. we recommend barrier measures adapted to young people, early detection and management of infected children.

Eligibility criteria:
inclusion criteria: * children aged 0-15 years suspected of having covid-19 whose data were in the dsre database were included exclusion criteria: * children whose data is not complete

Keywords: factors, covid-19, children, database, niger
contracture reduction following bunionectomy: a longitudinal, controlled trial

Conditions: Hallux Limitus

Summary: to determine the efficacy of metatarsal dynasplint sytem (mtp) in reducing contracture of hallux limitus secondary to bunionectomy, in a longitudinal, controlled trial.


Eligibility criteria:
inclusion criteria: * diagnosis 1st mtj contracture following bunionectomy exclusion criteria: * current treatment with botulinium toxin-a (botox), lower extremity * current treatment fluoroquinolones (antibiotic medication) * current use of muscle relaxant medications * fibromyalgia * stroke, cva, brain injury, spinal cord injury, or any neural pathology causing plasticity or hypertonicity * treatment with electrical stimulation assisting ambulation (i.e bioness, walkaide, parastep, etc.)
expanded access for bulevirtide

Conditions: Chronic Hepatitis Delta Virus Infection

Summary: the goal of this study is to provide access to bulevirtide (blv (gs-4438), hepcludex®) to eligible participants with chronic hepatitis delta virus infection (chd).


Eligibility criteria:
key inclusion criteria: * diagnosed with chd as confirmed by medical records. * compensated liver disease with liver cirrhosis (defined by biopsy, fibroscan, or clinically by the treating physician) and child-pugh score ≤ 6. * positive hdv rna test within 6 months of initial eap request (only applicable to patients who have not received treatment with blv). key exclusion criteria: * coinfection with hepatitis c virus (hcv) (hcv viremia defined by polymerase chain reaction (pcr)) or uncontrolled hiv infection (cd4 \< 500 cells/mm\^3 and detectable hiv rna). * current or previous (within last 3 months from screening) decompensated liver disease, including coagulopathy, hepatic encephalopathy, and esophageal varices hemorrhage. * significant medical diseases or conditions, that might decrease the benefit-risk ratio of participating in this program to an unacceptable level, as determined by the treating physician. note: other protocol defined inclusion/exclusion criteria may apply.
neuromodulation in chronic ankle instability

Conditions: Ankle Sprains

Summary: ankle sprain is a common injury. around 712,000 sprains occur every day in the world. it is estimated that they account for 45% of sports injuries, being the second part of the body that is most frequently injured in sports. of the patients who suffer this injury, around 70% will develop chronic ankle instability, a situation that can cause residual pain, recurrent sprains, a feeling of lack of stability and decreased physical activity. two entities can be included in chronic ankle instability: mechanical instability, which involves movement of the joint beyond its physiological limit, and functional instability, which includes proprioceptive dysfunction, impaired neuromuscular control, postural control, and strength deficits. currently, the conservative treatment of these patients consists of neuromuscular training through the use of dynamic balance platforms, taping, joint mobilization, dry needling, and the use of plantar supports, balance training being the one that has shown the best result. ultrasound-guided percutaneous neuromodulation (pnm) is a recently used technique in the field of invasive physiotherapy that consists of applying a square wave biphasic electrical current through an acupuncture needle-like electrode that is place in close proximity to the nerve with ultrasound guidance. the aim of this study is to evaluate the effectiveness of pnm in ankle instability.


Eligibility criteria:
inclusion criteria: * ankle instability exclusion criteria: * subjects taking nsaids, analgesics or muscle relaxants * epilepsy * belonephobia or allergy to metals
study of cartilage relaxometry and physical activity in osteoarthritis

Conditions: Osteoarthritis

Summary: this study is the radiological component of an earlier registered trial under the title: efficacy of exercise on physical function and cartilage health in patients with knee osteoarthritis. the main purpose in this component of the study is to evaluate the efficacy of aerobic exercise and strength training on the t2 and t1 rho relaxation times of the articular cartilage. it has been proven that exercise can improve function and reduce the need for analgesics in patients with osteoarthritis. with this study, we wish to investigate if different kinds of exercise can cause measurable improvements in t2 and t1 rho relaxation times of the articular cartilage, and also if this improvements are transient or permanent.


Eligibility criteria:
inclusion criteria: * women and men aged 45-65 years * clinical knee oa according to the american college of rheumatology clinical criteria 17 * kellgren and lawrence radiographic oa grade 2 and 3 (mild to moderate radiographic oa) exclusion criteria: * severe knee oa according to the kellgren and lawrence classification (grade 4) * other known major musculoskeletal impairments in the lower extremities or the back or prostheses in any joint of the lower extremities * known coronary heart diseases or cancer * body mass index \> 35 * scheduled for surgery in any joint * known mental or psychologic diseases * known drug abuse * persons who already perform sports related moderate physical activity more than two times a week * contraindications for magnetic resonance imaging (specific point list at diagnostic imaging division, akershus university hospital) * not speaking norwegian

Keywords: osteoarthritis,articular cartilage, relaxometry, morphometry, mri, t2 mapping, t1 rho
real-world clinical efficacy of abatacept in the t3 data registry

Conditions: Arthritis, Rheumatoid

Summary: the purpose of this study is to assess the effectiveness of abatacept in real-world clinical practice. the main hypothesis to be examined in this study is, "abatacept's effectiveness results in a single real-world clinic (n = 100) are reproducible at another site (n \~= 200)".

two secondary hypotheses that will be tested are: * abatacept aids in achieving low disease activity or clinical remission in patients of the following rheumatoid arthritis (ra) sub-groups: rf+/ccp+, rf+/ccp- rf-/ccp+ rf-/ccp-; first time on a bio-tech drug; having previously failed a biological drug; having interstitial lung disease; identified as disabled; twenty-eight individual joints identified as {swollen, painful, tender, deformed or having decreased range of motion}; on or not on oral dmard; age; or gender. * a database with sufficient attributes exists from which a patient's efficacy on abatacept is accurately predictable.

Eligibility criteria:
inclusion criteria: * diagnosed with rheumatoid arthritis * have used abatacept for 3 or more months exclusion criteria: * none

Keywords: retrospective database data warehouse data mining collaborative effectiveness comparative effectiveness outcome based medicine evidence based medicine
the impact of a helicopter emergency medical system on prognosis in stroke patients

Conditions: Thrombolysis

Summary: stroke is a leading cause of death and disability, and 15 million people suffer a stroke each year; one-third die and one-third are left permanently disabled. because the risk of stroke increases with age, it has been considered a disease of the elderly, but stroke also occurs in middle-aged people. thrombolysis with tissue plasminogen activator (tpa) is the preferred choice of reperfusion therapy of ischemic stroke if performed within 4.5 hours from symptom onset. time to thrombolysis is associated with improved outcome: the sooner the treatment, the less risk of serious - and possibly permanent - damage to the brain. unfortunately, only a small fraction of stroke patients make it to thrombolysis within the 4.5-hour; one explanation may be system delays including prolonged transportation. in may 2010, the first physician-staffed helicopter emergency medical service (hems) was implemented in the eastern part of denmark. an observational study evaluating the short-term effects of hems implementation compared patients transported by conventional ground ambulance (ground emergency medical service (gems)) to patients transported by hems. patients transported by helicopter had increased time to specialized care. however, both 30-day and 1-year mortality was slightly lower in patients transported by hems, although not significant, as was the degree of disability at three months measured by the modified rankin scale (mrs).


Eligibility criteria:
inclusion criteria: * all patients arriving at the regional stroke unit at copenhagen university hospital, roskilde, suspected of an acute vascular condition within the geographical area covered by both hems and gems in a 40-month period from january 1st 2010 until april 30th 2013. exclusion criteria: * for patients with multiple contacts; only the first contact is included in the data for analysis.

Keywords: helicopter emergency medical system mortality labour market affiliation modified rankin scale
trial to compare the effectiveness of group versus individual therapy on alternate days in patients with subacromial impingement syndrome

Conditions: Mobility

Summary: pathology of the rotator cuff and subacromial bursa is considered to be the principal cause of pain and symptoms arising from the shoulder. physiotherapy specialists often disagree about which type of exercise is most appropriate. manual physiotherapy combined with guided exercise is a commonly applied clinical treatment, but no proof of its effectiveness has been shown. clinical trials comparing results of treating subacromial syndrome of the shoulder with guided self-treatment and conventional physiotherapy yielded a slightly higher improvement, basically because patients suffered from chronic tendinitis and the treatment period lasted only two weeks. that is the reason why the investigators propose a long-term follow-up study and a more complete assessment of effectiveness of the exercise prescribed to improved this pathology. objectives: * assessment of effectiveness of two different types of treatment of subacromial syndrome of the shoulder. * comparison of effectiveness of both treatments in order to select that one yielding better results as the one to be applied as a routine practice. patients will be assigned one of the following treatments: * group 1: patients will be taught exercises in groups of six people, on a daily basis for twelve sessions. * group 2: patients will be taught the same exercise as group 1, individually, and will receive manual therapy consisting of muscular and joint re-centering. a modified version of the constant scale will be used to assess mobility and pain shoulder.


Eligibility criteria:
inclusion criteria: * history of shoulder pain defined as at least 2 positive results in subacromial impingement tests. * self-perceived pain reported by the patient under clinical examination of the shoulder. * a minimum of 90º mobility in flexion. exclusion criteria: * luxation, a history of surgery, or evidence the current shoulder pain or other symptoms under cervical examination or other shoulder bone disease, except for acromioclavicular joint arthrosis. * patients were receiving other physiotherapy or rehabilitation treatments. * patients had been treated for sis (subacromial impingement syndrome) with injection of anti-inflammatory or analgesic drugs in the last month.
ultrasound versus fluoroscopy-guided selective lumbar nerve root injection

Conditions: Lumbar Radiculopathy

Summary: the study is conducted to compare pain relief, accuracy and safety and radiation exposure of selective lumbar nerve root injection for lumbar radicular pain using ultrasound guidance versus fluoroscopy guidance

radicular pain is believed to be induced by irritation or inflammation of a nerve root caused by mechanical pressure or chemical irritation from degeneration herniation or rupture of intervertebral disc .nerve root steroid injection is the most commonly performed minimally invasive technique for treatment of radicular pain in lumbar spine.the mechanism of action of steroids is to reduce inflammation by reduction in proinflammatory mediators around the nerve root, causing reduction in pain levels . although fluoroscopy guided technique is the most widely accepted method in lumbar selective nerve root injection, but recently ultrasound technique has gained acceptance among physicians due its reliability, efficacy, real-time guidance of injection and reduction of radiation exposure. real-time guidance of injection provided by ultrasonography allows for good identification of the spinous process and adjacent structures such as lamina, zygapophyseal articulations and transverse process allowing for safer and potentially equally effective injection technique. the patients are randomly allocated into two groups; one group will receive injection under fluoroscopy guidance and the other group will receive injection under ultrasound guidance. the two groups are compared in terms of pain relief, accuracy and safety and radiation exposure.

Eligibility criteria:
inclusion criteria: * adult patients aged 18-60 years . * both sexes . * with unilateral chronic lumbar radicular pain for more than 3 months. * cooperative and oriented patients. * all patients are diagnosed by a neurologist for radicular low back pain through clinical presentation, medical examinations, computed tomography (ct), or magnetic resonance imaging (mri). exclusion criteria: * uncontrolled diabetes. * infection at the site of injection. * spine fractures. * previous back surgery. * progressive neurologic disorders. * fever. * peripheral neuropathy. * presence of motor or sphencteric disturbance. * bilateral radicular pain. * allergy to substance of injection. * patients with body mass index (bmi) more than 35.

Keywords: lumbar radicular pain selective nerve root injection ultrasound selective lumbar nerve root injection