venous thromboembolism prophylaxis in a tertiary uae hospital: comparison of clinical practice guidelines.

Conditions: Venous Thromboembolism

Summary: study title:assessment of adherence to guidelines for thromboprophylaxis in a tertiary united arab emirates (uae) hospital study site: al qassimi hospital, united arab emirates study objectives: the primary objective of this study is assessment of appropriateness of vte prophylaxis administered to critically ill and surgical patients for whom pharmacologic treatment is indicated according to the american college of chest physicians (accp) 2012 guidelines. the secondary objective is to: 1.identify some causes of inadequate vte prophylaxis in different patient populations, such as prescribing problems and errors at the level of administration. study design: cross sectional retrospective observational study sample size: approximately 400 study population: inclusion criteria patients who meet the following criteria will be included: 1. patients aged 18 and above. 2. patients admitted to any of the critical care units, or the general or orthopaedic surgical wards. 3. patients who have been in hospital more than 24 hours. 4. caprini score \> 1 (see procedure) exclusion criteria patients with any of the following criteria will be excluded: 1. patients who have been admitted to a critical care unit and transferred out to a non surgical unit within 24 hours of admission. 2. patients receiving oral anticoagulant therapy for indications other than vte prophylaxis or treatment, such as atrial fibrillation and prosthetic heart valves. study outcome measurements: the main outcome measure of interest is to determine the proportion of patients who have received inappropriate or inadequate vte prophylaxis considering their calculated risk factor compared to the recommended prophylactic measures for that risk. secondary outcome measures are to identify whether there is inadequate vte prophylaxis because of medication errors such as missed doses or wrong doses given. study duration: 4 months statistical analysis data was entered into microsoft excel® and subsequently checked to ensure accurate data entry and correct any errors. it was subsequently exported into spss version 20 where it will be analysed.quantitative data such as age was expressed mean (± standard deviation). categorical data such as gender, risk factors for bleeding, type of mechanical and pharmacologic prophylaxis, missed doses and wrong doses were expressed as number and percentage of population.the student's t-test was used to analyse parametric data. the pearson chi-square test and wilcoxon rank sum test were used to analyse non parametric data. simple and multiple logistic regression analysis was done to identify factors that are associated with inappropriate vte prophylaxis. factors that were included in the analysis included: age, type of admission (medical or surgical), area of admission (critical care, general surgery, orthopaedic surgery), caprini score, and inappropriate vte prophylaxis as the outcome. a p-value of less than 0.05 was be considered statistically significant.


Eligibility criteria:
inclusion criteria: 1. patients aged 18 and above. 2. patients admitted to any of the critical care units, or the general or orthopaedic surgical wards. 3. patients who have been in hospital more than 24 hours. 4. caprini score \> 1 (see procedure) exclusion criteria: 1. patients who have been admitted to a critical care unit and transferred out to a non surgical unit within 24 hours of admission. 2. patients receiving oral anticoagulant therapy for indications other than vte prophylaxis or treatment, such as atrial fibrillation and prosthetic heart valves.