Kornimate/medical-research-clean huggingface dataset:
source-monitoring & psychosis

Conditions: Psychosis

Summary: source-monitoring is a cognitive process that refers to the ability to remember the source of an information. some studies have showed source-monitoring deficits in patients with schizophrenia as well as in individuals at ultra-high risk for psychosis (uhr) and in first-episode psychosis patients (fep). source-monitoring deficits have thus been proposed as a potential early risk factor for psychosis. however, further studies are needed to better characterize this deficit. the aim of this project is to investigate source-monitoring performances in uhr, fep patients and healthy controls (hc) and to characterize these deficits in terms of brain anatomy, basic auditory processes and social functioning.

ninety participants will be included in the study: 30 uhr, 30 fep and 30 healthy controls. all the participants will complete a standardized source-monitoring task, an mri acquisition (3d-t1 anatomical scan), a tone-matching task as well as a socio-demographic and clinical evaluation including an assessment of the social functioning.

Eligibility criteria:
inclusion criteria: * men and women aged between 18 and 30 * having given their written informed consent * french speakers and readers * absence of hearing impairments (or tinnitus) that could prevent the successful completion of tasks involving listening to sounds or words * absence of visual impairments that could prevent the successful completion of tasks involving reading on the screen * for the healthy control group, no history of previous diagnosed psychiatric disorders (according to the criteria of the diagnostic and statistical manual of mental disorders - dsm5), absence of relatives diagnosed with spectrum disorder schizophrenia and bipolar disorder (dsm5), absence of psychotic prodromes measured by a score of less than 6 in the "prodromal questionnaire" - pq-16 (ising et al., 2012), absence of drug treatments (except oral contraception). * for the uhr group, meeting the uhr criteria according to the "comprehensive assessment of at-risk mental state" (caarms). * for the fep group, presenting with daily psychotic symptoms for at least a week. exclusion criteria: * do not consent to be included in the study * contraindication to mri scan * history of neurological disease * pregnancy * being under tutorship or curatorship * having developed musical abilities (that is, regularly practicing a musical instrument)

Keywords: source-monitoring at-risk mri neuroimaging
walking meditation exercise in breast cancer patients

Conditions: Breast Cancer

Summary: this study is to evaluate the effects of walking meditation on vascular function in breast cancer patients receiving anthracyclines chemotherapy

walking meditation program will be based on aerobic walking exercise combined with buddhist meditation. the subjects will perform walking while listening to the sound "budd" and "dha" and squeeze rubber balls according to the sound in order to practice mindfulness while walking. in phase 1 (week 1-6), walking meditation will be conducted at initial moderate intensity (41-50% heart rate reserve) 3 sets, 10 minutes per set and rest 3 minutes between set in phase 2 (week 7-12), the training intensity will be increased to ultimate moderate intensity (51-60% heart rate reserve) 3 sets, 15 minutes per set and rest 3 minutes between set. in both phases of the training, the frequency of walking meditation training is three times a week.

Eligibility criteria:
inclusion criteria: 1. the inclusion criteria included stage 1-2 of breast cancer patients after an operation with or without hormone receptor positive and her2 positive. 2. all participants will be planned to use anthracyclines chemotherapy in next 1 month by oncologist. 3. all participants did not participate in any exercise training in the past 6 months 4. all participants are free from acute or chronic renal failure, heart failure, myasthenia gravis, pregnancy and history of smoke. exclusion criteria: 1. participants will be excluded if they dropped out or completed less than 80% of the training schedule.

Keywords: walking meditation vascular function flow-mediated dilatation breast cancer patients anthracyclines chemotherapy
a questionnaire for endoscopic prediction improvement of gastrointestinal cancer

Conditions: Early Detection of Cancer

Summary: despite improvements in a range of chemo, radio and surgical therapies, the overall survival at 5 years from gastrointestinal cancer remains poor. endoscopic early diagnosis is a key strategy to improve survival but the detection rate of early cancer varies among different countries. risk factor questionnaire result is easy to be obtained and may be of great help for improving the detection rate. the aim of this research is to validate a risk factor questionnaire to help predict gastrointestinal cancer therefore allowing earlier diagnosis and higher detection rate.


Eligibility criteria:
inclusion criteria: * patients aged more than 18 years with or without gi symptoms attending for endoscopy. exclusion criteria: * patients unable to cooperated the endoscopy or unable to complete it. people with endoscopy contraindications are naturally excluded.

Keywords: early detection of cancer gastrointestinal neoplasms endoscopy, gastrointestinal
progression of cognitive and physical symptoms in multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the purpose of this study is to look at multiple sclerosis patients process of awareness, learning, and judging status over a 3 year time period.

patients with multiple sclerosis (ms) frequently experience cognitive and emotional difficulties. theses neuropsychiatric symptoms are known to be associated with reduced quality of life. however, little is known about the evolution of ms patients' neuropsychiatric difficulties and how these neuropsychiatric changes may be related to other ms symptoms. the purpose of the present study is to examine ms patients' cognitive and emotional status over time as part of standard neuropsychological evaluations in a private practice setting. ms patients presenting for neuropsychological evaluation at the midamerica neuroscience institute will be provided with the option of participating in thorough evaluation of their cognitive and affective ms symptoms. they will then be followed clinically and receive re-evaluation over a period of 3 years on a yearly basis. it is hoped that this study will help us obtain a better understanding of the factors associated with worsening cognition in ms. a greater understanding of the factors associated with cognitive and affective decline in ms help could lead to the early identification and treatment of at-risk patients.

Eligibility criteria:
inclusion criteria: * male/female subjects at least 18 years of age with a diagnosis of clinically definite multiple sclerosis (cdms) or clinically isolated syndrome (cis)as confirmed by a neurologist. * subjects must be able to give written informed consent and comply with the study protocol. subjects must also be able to read, write and understand english. * are capable of performing the requirements of the neuropsychological test battery. exclusion criteria: * as judged by the investigator, any clinically significant, unstable or major concomitant disorder or medications. * in the opinion of the investigator should not participate in the study.

Keywords: cognition, affective ms symptoms
cleavage pattern of embryos and oxidative parameters

Conditions: Infertility

Summary: to investigate prospectively whether embryos with abnormal cleaving pattern have different oxidative parameters from normally cleaving embryos, and to analyze whether these parameters have an association with demographic, laboratory and clinical parameters including treatment outcome.

to investigate prospectively whether embryos with abnormal cleaving pattern have different oxidative parameters from normally cleaving embryos, and to analyze whether these parameters have an association with demographic, laboratory and clinical parameters including treatment outcome.

Eligibility criteria:
inclusion criteria: * patients undergoing ivf for the treatment of infertility exclusion criteria: * age \ 45 years old * patients with no embryos with direct cleavage
home exercise telerehabiliation for ms

Conditions: Multiple Sclerosis

Summary: the primary purpose of this study is to evaluate the effects of an individualized telerehabilitation program on mobility, fatigue, and quality of life for veterans with ms. the secondary purpose was to assess adherence to exercise recommendations and overall satisfaction with the intervention.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of ms based on the mcdonald criteria * expanded disability status scale (edss) of 3.0 - 6.5 * cognitive ability (montreal cognitive assessment score \>23/30) * physician clearance for exercise participation * physical therapy referral exclusion criteria: * ms-related exacerbation within last 3 months * unstable cardiac or pulmonary disease * active substance abuse * uncontrolled seizures

Keywords: multiple sclerosis rehabilitation telerehabilitation telehealth veteran health physical therapy
a study of ly3499446 in participants with advanced solid tumors with kras g12c mutation

Conditions: Advanced Solid Tumor; Non-Small Cell Lung Cancer; Colorectal Cancer

Summary: the reason for this study is to see if the study drug ly3499446 is safe and effective in participants with solid tumors with kras g12c mutation.


Eligibility criteria:
inclusion criteria: * participants must have diagnosis of a solid tumor with kras g12c mutation that did not respond to at least 1 line of standard therapy and has spread to other part(s) of the body * for phase ii, participants must be willing to have new tumor tissue biopsies (doctor removes a small amount of tissue) during the study if it does not cause undue risks to health * participants must be willing to use highly effective birth control * participants must have adequate organ function * participants must be able to swallow capsules exclusion criteria: * participants must not have certain infections such as hepatitis or tuberculosis or hiv that is not well controlled * participants must not have another serious medical condition including a serious heart condition, such as congestive heart failure, unstable angina pectoris, or heart attack within the last three months * participants must not have cancer of the central nervous system that is not stable * participants must not be pregnant or breastfeeding * participants must not use herbal supplements
oxford niaspan study: effects of niaspan on atherosclerosis and endothelial function

Conditions: Atherosclerosis

Summary: aim 1 will test the hypothesis that elevation of high-density lipoprotein (hdl) through treatment with niaspan will accelerate the regression of atherosclerotic plaque in patients with established atherosclerosis. the investigators will therefore study patients with atherosclerosis in the aorta and carotid artery. plaque quantification will be with magnetic resonance imaging (mri). aim 2 will assess the ability of niaspan to improve endothelial function in patients with coronary artery disease and type ii diabetes mellitus, who typically have low high-density lipoprotein cholesterol (hdl-c), and high risk of cardiovascular events.

patients will be randomised to receive either niaspan 2000mg each night or placebo. niaspan will be commenced at 375mg daily and increased to 500mg then to 750, and 1000mg daily at weekly intervals. after 4 weeks the dose will be increased to 1500mg daily and, after a further one month, the study dose of 2000mg daily2 will be instigated. immediately before randomization (to exclude patients unable to tolerate mri because of claustrophobia), and 6 and 12 months after commencing treatment participants will undergo mr examination.

Eligibility criteria:
inclusion criteria: * aim 1: carotid or peripheral arterial disease and hdl \<1mmol/l * aim 2: coronary artery disease, type ii diabetes and hdl \<1mmol/l exclusion criteria: the following will constitute exclusion criteria: * inability to provide informed consent, * known intolerance of a study drug, * use of niacin or a fibrate at time of screening, * ast or alt elevated above normal range at time of screening * use of oral nitrates or nicorandil * uncontrolled or newly diagnosed diabetes mellitus * symptomatic heart failure or heart failure requiring treatment with diuretics * fasting triglycerides \> 500mg/dl \[5.65mmol/l\] * patients with acute coronary syndromes, active peptic ulcer disease, * active gout, * standard exclusions for mri will apply, i.e. pacemakers, implantable defibrillators, metal implants or embedded metallic fragments of any kind.
pharmacokinetic and pharmacodynamic study of s-1 in patients with digestive organ cancer

Conditions: Gastric Cancer; Esophageal Cancer; Pancreatic Cancer; Colon Cancer

Summary: s-1 is a novel oral fluorouracil antitumor drug that consists of tegafur which is a prodrug of 5-fluorouracil (5-fu); 5-chloro-2,4-dihydropyridine (cdhp), which inhibits dihydropyrimidine dehydrogenase (dpd) activity; and potassium oxonate (oxo), which reduces gastrointestinal toxicity. 5-fu is metabolized by cyp2a6 and dpd. in this study, the researchers investigate the influences of differences in activities of cyp2a6 and dpd on pharmacokinetics and pharmacodynamics of s-1 and clinical outcomes in digestive organ cancer patients treated with s-1.


Eligibility criteria:
inclusion criteria: * patients with digestive organ cancer exclusion criteria: * patients without digestive organ cancer
patient-portal vs text-based hypertension monitoring among black medicaid/medicare patients

Conditions: Hypertension; Cardiovascular Diseases

Summary: the coronavirus disease 2019 (covid-19) pandemic has uprooted conventional health care delivery for routine ambulatory care, requiring health systems to rapidly adopt telemedicine capabilities. the digital divide, has been well documented with lower rates of technology and broadband adoption among racial/ethnic minorities. additionally, black patients suffer a disproportionate burden of hypertension and cardiovascular disease. this study will implement a text-based home hypertension monitoring program among black medicaid patients with hypertension and cardiovascular disease (cvd) and compare its uptake to the currently available blood pressure monitoring program using the patient portal that is integrated into the electronic health record (ehr).


Eligibility criteria:
inclusion criteria: * self-identified black race * medicaid or medicare insurance * hypertension * cardiovascular disease or presence of at least 1 cardiovascular risk factor * seen for in-person consultation at the heart and vascular clinic at the hospital of the university of pennsylvania exclusion criteria: * does not speak english * already owns a bp cuff * does not have internet access or a phone 15 with texting capabilities

Keywords: racial disparities digital technology hypertension
the effect of coffee consumption on the serum levels of leptin, folic acid, and vitamin b12

Conditions: Atherosclerosis

Summary: the effect of coffee and body weight during the last 3 months on the level of leptin, folic acid, and vitamin b12

coffee consumption has been associated with several risk factors leading to cardiovascular diseases (cvds), including hyperhomocysteinemia and hyperlipidemia. frequent coffee consumption has beneficial effects in reducing the risk of diabetes mellitus (dm) type 2, obesity, liver disease, cvds, some types of cancer, parkinson's disease, and alzheimer's disease. controversies concerning coffee consumption benefits and risks in regards for cvds were mentioned in many studies. folic acid and vitamin b12 are necessary vitamins in homocysteine metabolism which is a risk factor for atherosclerosis. leptin, is a hormone linked to obesity and it could be related to atherosclerosis. the combined effect of coffee consumption and body weight on the levels of leptin, folic aid, and vitamin b12 is not well studied. in our study, we will study the effect of coffee consumption in males with different body mass indices to see the effect of several important parameters such as leptin, folic acid, and vitamin b12.

Eligibility criteria:
inclusion criteria: * male, * asu student, * do not have any acute or chronic medical conditions. exclusion criteria: * students who used any medications for either an acute and/or a chronic condition during the past 3 months prior to the study entry.

Keywords: coffee bmi leptin folic acid vitamin b12
retrospective evaluation of delirium data from previous study patients for studies at the clinic for anesthesiology and intensive care medicine ccm/cvk/cbf

Conditions: Delirium

Summary: evaluation of several studies of the clinic for anesthesiology and intensive care medicine ccm/cvk/cbf to create a register with the delirium data from anesthesiology study patients between 18 - 100 years. the primary purpose of the register is to assess factors influencing the development of delirium. in a subproject, risk factors that may lead to the development of postoperative delirium in the elderly will be evaluated with regard to gender differences using patients from the age of 60 with different surgical procedures. the risk factors examined are based on the evidence-based and consensus-based recommendations of the esa guideline and literature review. in addition, the delirium incidence rate and the delirium severity is examined regarding gender differences.


Eligibility criteria:
inclusion criteria: * male and female patients age ≥ 18 years of studies of the clinic for anesthesiology and intensive care medicine ccm/cvk/cbf exclusion criteria: * none
combination chemotherapy followed by surgery with or without radiation therapy in treating young patients with stage ii or stage iii neuroblastoma

Conditions: Neuroblastoma

Summary: rationale: drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. giving more than one drug (combination chemotherapy) may kill more tumor cells. giving combination chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. radiation therapy uses high-energy x-rays to kill tumor cells. giving radiation therapy after surgery may kill any tumor cells that remain. it is not yet know whether combination chemotherapy followed by surgery alone is more effective than combination chemotherapy followed by surgery and radiation therapy in treating neuroblastoma. purpose: this randomized phase iii trial is studying combination chemotherapy followed by surgery to see how well it works compared to combination chemotherapy followed by surgery and radiation therapy in treating young patients with stage ii or stage iii neuroblastoma.

objectives: * compare the local control and event-free and overall survival of young patients with stage iib and iii neuroblastoma treated with neoadjuvant combination chemotherapy followed by surgery with vs without radiotherapy. * determine the toxic effects of these regimen in these patients. outline: this is a multicenter, randomized study. * induction combination chemotherapy: patients receive vincristine iv and cyclophosphamide iv on day 1. patients also receive cisplatin iv continuously over 24 hours on day 1 and etoposide iv over 4 hours on day 2 during courses 1, 3, and 5 and carboplatin iv over 1 hour and etoposide iv over 4 hours on day 1 during courses 2 and 4. treatment repeats every 21 days for 5 courses in the absence of disease progression or unacceptable toxicity. patients then proceed to surgery unless complete resection was done during initial staging and complete response was maintained. * surgery: patients undergo biopsy or surgical resection of the tumor 2-3 weeks after completion of induction combination chemotherapy. * post-surgical treatment: patients are randomized to 1 of 2 treatment arms. * arm i: patients receive two additional courses of combination chemotherapy comprising vincristine, cisplatin, etoposide, and cyclophosphamide in course 6 and vincristine, carboplatin, etoposide, and cyclophosphamide in course 7. * arm ii: patients undergo radiotherapy 2-4 weeks after surgery. beginning 3 weeks after completion of radiotherapy, patients receive chemotherapy as in arm i after completion of study treatment, patients are evaluated periodically. projected accrual: a total of 150 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: * histologically confirmed stage iib or iii neuroblastoma * no n-myc amplification patient characteristics: * not specified prior concurrent therapy: * no prior chemotherapy or radiotherapy

Keywords: localized resectable neuroblastoma localized unresectable neuroblastoma regional neuroblastoma
dose titration of propofol for tracheal intubation in children with sevoflurane inhalation induction

Conditions: Pediatric Urinary Disorders

Summary: dose titration of propofol for tracheal intubation in children with sevoflurane inhalation induction.


Eligibility criteria:
inclusion criteria: * pediatric patients scheduled for elective day case surgery were enrolled. exclusion criteria: * history of obstructive sleep apnea * evidence of cardiorespiratory disease * those who were obese or allergic to any of the anesthetic agents in this study * those with an anticipated difficult airway, full stomach * history of malignant hyperthermia or other myopathy were excluded.
rirs with tip flexible pressure-controlling ureteral access sheath versus mini pcnlfor kidney stones

Conditions: Kidney Stone

Summary: the goal of this observational study is to compare the safety and efficacy between rirs with tip flexible pressure-controlling ureteral access sheath and mini percutaneous nephrolithotripsy（pcnl） for the treatment of 2-3-cm kidney stones.

retrograde intrarenal stone surgery (rirs) has become one of the most common treatments for renal stones. the development of ureteral access sheath (uas) is a significant advance in rirs. in recent years, various improvements have been made to uas, especially the emergence of a suction uas and a tip flexible uas. using the advantages of suction and tip flexible technology, our team developed a tip flexible pressure-controlling uas, which significantly improves the safety and effectiveness of rirs. however, the current guidelines can recommend the indication of rirs in kidney stones less than 2cm, and percutaneous nephrolithotomy(pcnl) is still preferred for kidney stones larger than 2 cm. therefore, this study is the first to compare the safety and efficacy between rirs with tip flexible pressure-controlling uas and mini pcnl in the treatment of 2 to 3 cm kidney stones.

Eligibility criteria:
inclusion criteria: * adults aged ≥ 18 years * american society of anesthesiology score 1-2 * kidney stone diameter of 2-3 cm confirmed by ct * capable of giving written informed consent, which includes adherence with the requirements of the trial exclusion criteria: * patients with abnormal urinary tract anatomy (such as horseshoe kidney or ileal conduit) * patients with uncontrolled uti * patients with health or other factors that are absolute contraindications to rirs or pcnl .patients unable to understand or complete trial documentation.