Kornimate/medical-research-clean huggingface dataset:
effects of rhomboids strength training regime among patients with upper crossed syndrome

Conditions: Upper Crossed Syndrome

Summary: upper cross syndrome (ucs) is characterized by weakening of the neck flexors and rhomboids and stiffness in the pectoralis major, upper trapezius, and levator scapulae. rhomboids major and minor need to be strengthened in order to enhance scapular stability and regain proper posture. the aim of this study is to determine effect of rhomboids strength training regime on pain, craniovertebral angle and disability among patients with upper crossed syndrome.

this study will be a randomized controlled trial and will be conducted in haleema surgical hospital, shorkot city. non-probability convenient sampling will be used to collect the data. sample size of 38 subjects with age group between 20-45 years will be taken. data will be collected from the patients having present complaint of upper crossed syndrome pain. outcome measures will be taken using numeric pain rating scale (nprs) for pain, craniovertebral angle, and neck disability index questionnaire for disability. an informed consent will be taken. subjects will be selected on the basis of inclusion and exclusion criteria and will be equally divided into two groups by computer-generated stratified randomization. the study will be a single-blind assessor. both the groups will receive hot pack, tens, posture training and stretching exercises while group a will receive rhomboids strengthening exercises additionally. outcome measures will be measured at baseline and after 4 weeks. data analysis will be done by spss version 25.

Eligibility criteria:
inclusion criteria: * age group between 20 and 45 years * both gender male and female * subject with head neck angle less than 50 degrees(for forward head posture). * subject with positive jandas upper crossed syndrome tests . * population with occupation tailor, computer users and students. exclusion criteria: * • exclusion criteria patients were excluded if they were diagnosed with the following conditions for ˃6 months * tuberculosis, carcinoma, heart disease, and osteoporosis * neural disorders due to prolapsed intervertebral disc * any trauma or localized infection in upper back region

Keywords: craniovertebral angle pain disability
macular hole surgery with temporal inverted internal limiting membrane flap (martial)

Conditions: Macula Hole

Summary: since 1991, idiopathic macular holes (mh) can benefit from an effective treatment initially involving pars plana vitrectomy, stripping of epiretinal membranes and intraocular gas tamponade followed by facedown positioning. the initial 58% success rate has further increased to 85-100% with internal limiting membrane (ilm) peeling. however, complete ilm removal has been shown to lead to anatomic changes causing the retina to have the appearance of a dissociated optic nerve fiber layer (donfl). moreover, it has been associated with decreased retinal sensitivity that may cause visual discomfort despite good visual acuity. nawrocki et al. recently suggested to reduce the area of peeled ilm (temporal inverted ilm flap technique) in order to minimize iatrogenic trauma while maintaining satisfactory surgical outcomes. the aim of this study is to compare the incidence of donfl appearance and retinal sensitivity after macular hole surgery in eyes that underwent temporal inverted ilm flap technique and eyes that had complete ilm peeling


Eligibility criteria:
inclusion criteria: * patients older than 18 years old exclusion criteria: * underage patients * history of intraocular surgery (except for cataract surgery) * macular hole secondary to trauma, diabetic retinopathy, uveitis or associated with retinal detachment * concurrent macular disease (diabetic maculopathy, age-related macular degeneration)
study of lv5fu2 versus folfox for curatively-resected, node-positive esophageal squamous cell carcinoma

Conditions: Curatively-resected, Node-positive Esophageal Squamous Cell Carcinoma

Summary: oxaliplatin is a platinum analogue that has significant antitumor activity with better tolerability than cisplatin. the objective of the study is to evaluate the safety and activity of leucovorin and 5-fluorouracil and leucovorin and 5-fluorouracil plus oxaliplatin combination chemotherapy given as adjuvant therapy for curatively-resected, node-positive esophageal cancer.


Eligibility criteria:
inclusion criteria: * aged 20 years or older * histologically confirmed squamous cell carcinoma of esophagus * curatively (r0) resected, lymph node positive * ecog performance status of 0 or 1 * restoration of oral intake \>1500 kcal/d * no prior chemotherapy except for neoadjuvant ones * no prior radiotherapy within 1 month before registration * adequate marrow, hepatic, renal and cardiac functions * provision of a signed written informed consent exclusion criteria: * severe co-morbid illness and/or active infections * prior treatment with oxaliplatin * pregnant or lactating women * active cns metastases not controllable with radiotherapy or corticosteroids * known history of hypersensitivity to study drugs
dose response study of a topical gel for the treatment of raynaud's phenomenon

Conditions: Raynaud's Disease; Raynaud's Disease Secondary to Scleroderma; Raynaud's Disease Secondary to Autoimmune Disease

Summary: the purpose of this study is to determine the response to two different strengths of a topical gel containing nitroglycerin in patients with raynaud's disease.

the purpose of this clinical study is to determine, in a controlled fashion, the response to two dosage strengths of a topical gel formulation of nitroglycerin, mqx-503, in the determination of changes in finger blood flow and skin temperature in the fingers of patients with moderate to severe primary raynaud's phenomenon and with raynaud's phenomenon secondary to autoimmune diseases, such as scleroderma. the dosage strength response in the treatment of the symptoms (pain, tingling, numbness) will also be monitored.

Eligibility criteria:
inclusion criteria: * outpatients, 18 to 75 years * clinical diagnosis of raynaud's, or observed event by study physician, or symptoms with reduced blood flow as meausred using laser doppler equipment * agree to have test gels applied to finger * discontinue current vasodialator therapeis for raynaud's treatment * four weeks from last clinical trial participation * agree not to use any other investigational medications or therapies to treat raynaud's and its symptoms while participating in this study including other dosages or forms of nitroglycerin, isosorbide dinitrate, fenoldopam mesylate, milrinone lactate, nifedipine, diltiazem, felodipine, nimodipine, nisoldipine, and verapamil * negative pregnancy test for women prior to study start and agree to use effective contraception throughout * must be able to give written informed consent and comply with all study requirements exclusion criteria: * concurrent use of any nitrate medication or medications known to interact with nitroglycerin such as sildenafil, and other treatments for erectile dysfunction * patients who have a known allergy to nitroglycerin or common topical gel ingredients * patients with a history of migraine, cluster or vascular headaches, or those who suffer from chronic pain * patients with a history of an unstable medical problem or any current condition that would interfere in participation in the study * patients unable to complete pain assessment instructions * patients who in the last three months have had a myocardial infarction, uncontrolled congestive heart failure, unstable angina, uncontrolled hypotension or uncontrolled hypertension * patients who have participated in another investigational drug study within four weeks of the first study treatment * patients with out of range laboratory screening values * patients who have had major abdominal, thoracic or vascular surgery within six months of the first study treatment * patients with open lesions or skin conditions where gel is to be applied * pregnant or nursing women * women who will not agree to comply with contraceptive requirements * patients with a history of poor compliance, poor cooperation or unreliability

Keywords: raynaud's nitroglycerin topical gel cold hands painful hands scleroderma
study on hyperlipidemia combined with carotid atherosclerosis with shenju granules

Conditions: Hyperlipidemia; Carotid Atherosclerosis

Summary: this study focuses on pwv as the main outcome, aiming to evaluate the efficacy and safety of shenju in treating patients with hyperlipidemia combined with carotid atherosclerosis, and provide a basis for traditional chinese medicine treatment of hyperlipidemia combined with carotid atherosclerosis.

hyperlipidemia is very harmful and easy to cause atherosclerosis. atherosclerosis is the main factor of carotid atherosclerosis. carotid atherosclerosis and plaque are usually the characteristic manifestations of atherosclerosis. carotid arteriosclerosis is closely related to stroke, and carotid arteriosclerosis, rupture and detachment of carotid plaques, carotid stenosis and occlusion can all lead to the occurrence of cerebrovascular events. early detection and evaluation of hyperlipidemia with carotid atherosclerosis by various means can effectively reduce the risk of cardiovascular and cerebrovascular diseases. in order to better serve the vast number of patients, professor wang lei has developed shenju granules based on traditional chinese medicine prescriptions and years of clinical experience. compared to decoction, shenju granules have a higher concentration, are more convenient to carry, and are easy to absorb. they have received unanimous praise from patients in clinical applications.

Eligibility criteria:
inclusion criteria: 1. the patient has informed consent and signed the informed consent form 2. age between 18-65 years old 3. meet the diagnostic criteria for hyperlipidemia and accompanied by carotid arteriosclerosis 4. meet the diagnostic criteria of tcm wet certificate: refer to the scoring standard of tcm wet disease scale exclusion criteria: 1. severe liver, kidney and cardiac insufficiency 2. any other serious disease or condition such as: malignant tumor, uncontrolled severe hypertension, diabetic ketoacidosis (acute complication/vascular abnormality), arrhythmia, coagulation abnormalities 3. have participated in another clinical study within 30 days prior to enrollment or have received a history of randomized ketoacidosis in this study 4. pregnant women, women preparing to become pregnant and lactating women 5. patients who are allergic to relevant chinese medicine ingredients 6. patients who have had a stent inserted 7. patients who the investigator determines are not suitable to participate in this study

Keywords: hyperlipidemia carotid arteriosclerosis bapwv
reducing the risk of alarm fatigue through the use of focused management in safety huddles

Conditions: Clinical Alarms

Summary: context: alarm fatigue is a threat to hospital patient safety. national surveys reveal that high alarm rates interrupt patient care, reduce trust in alarms, and lead clinicians to disable alarms entirely. safety huddles offer an appropriate forum for reviewing alarm data and identifying patients whose high alarm rates may necessitate safe tailoring of alarm limits. objectives: to evaluate the impact of a focused physiologic monitor alarm reduction intervention integrated into safety huddles that involves discussing safe monitor parameter adjustments on the physiologic monitor alarm rates of individual patients with high alarm rates who meet "low acuity" criteria. study design: a prospective, quasi-experimental pilot study of the impact of the huddle intervention on the alarm rates of low acuity high alarm rate individual patients discussed in huddles in the picu. the huddle intervention will consist of a script to facilitate the discussion of the alarm data. setting/participants: participants will include all low acuity patients and their providers in the picu at the children's hospital of philadelphia. study interventions and measures: the primary outcome is the rate of crisis and warning alarms per patient day for intervention cases as compared with others in the high alarm / low acuity cohort. safety measures will include unexpected changes in patient acuity or code blue events within one week of monitor change or discharge.


Eligibility criteria:
eligible primary participants will be the physicians and nurse practitioners caring for the picu patients who are discussed as part of the huddle interventions. eligible secondary participants will include all low acuity patients in the picu at the children's hospital of philadelphia. inclusion criteria primary subjects: any physician or nurse practioner caring for an intervention patient or control patient in the picu at chop secondary subjects: * low acuity patients as determined by optilink guidelines * high alarm patients (top 10-20%) * admission to the picu exclusion criteria primary subjects: none secondary subjects: patients who are medically ready for transfer out of icu or discharge home (status continuously tracked by charge nurse). patients who are medically ready for transfer out have an accepting service in place and a bed ready on the floor.

Keywords: alarm fatigue
a study measuring quality of life, treatment preference and satisfaction of adpkd patients in europe

Conditions: Autosomal Dominant Polycystic Kidney Disease

Summary: this is a prospective, non-interventional study (nis) measuring health-related quality of life (hrqol), treatment satisfaction, and other patient-reported outcomes (pros) of adpkd patients in europe.

this is a prospective, non-interventional study (nis) measuring hrqol, treatment satisfaction, and other pros of adpkd patients in europe. the study aims to enrol at least 486 patients. data will be prospectively collected at clinics, from medical notes and via pro measures for each patient at baseline, month 1, month 3 and subsequently at 3 month intervals up to and including the final assessment (18 months maximum follow-up time). no visits with the patients' treating physician will be imposed by the protocol. any clinical visits will occur as per normal clinical practice

Eligibility criteria:
inclusion criteria: * male and female aged ≥ 18 years. * patient has a diagnosis of adpkd between ckd stages 1-3, and is deemed by their treating physician to likely have rapidly progressing disease. * patient has a life expectancy greater than 18 months at time of enrolment. * patient is able and willing to give informed consent, if required according to local regulations. * patient is fluent in local language. exclusion criteria: * patient is currently participating in, or has in the last 12 months participated in an interventional clinical trial. * presence of any condition/circumstance which in the opinion of the investigator could significantly limit the complete follow up of the patient. * inability of the patient to complete pros remotely.

Keywords: adpkd ckd rapid progressor quality of life dce
single dose of clonazepam versus intermiittent diazepam for febrile seizures prevention

Conditions: Recurrent Febrile Convulsion

Summary: to study the efficacy and safety of single dose clonazepam compared with intermittent oral diazepam for prevention of recurrent febrile seizures in children who had three or more febrile seizures.

febrile seizures are the most common type of seizures disorder of young children. the risk of recurrences are 33 percent overall, half of them had at least one recurrent seizure (the 3rd febrile seizures). after that the recurrent rate is 50-100 percent depend on their risk factors. a few studies found that multiple recurrent febrile seizures might associated with language developmental delayed, poor speed performance quotient, attention deficit hyperactivity disorders. moreover, seizures are upsetting both parents and children. during the febrile illness, the intermittent diazepam, continuous phenobarbital and valproate are effective for prevention of the recurrences. because of the benign nature of a simple febrile seizures, the risks of side effects generally outweigh the benefits. however, there is no clinical guidelines for prevention of recurrent febrile seizures in the children who experienced multiple occurrences. the better prophylactic drug; safe, effective and easy to use, for prevention of recurrent febrile seizures in children with multiple recurrences might be needed. clonazepam, the long half-life benzodiazepine, is commonly used for treatment of epilepsy may be effective in preventing recurrent febrile seizures. this study, a single-blind, randomized clinical trial, single dose clonazepam at the time of fever present compared with oral diazepam during the fever to prevent the recurrent febrile seizures.

Eligibility criteria:
inclusion criteria: * age 6-60 months at date of enrollment * 3 or more episodes of clinically diagnosed febrile seizures exclusion criteria: * history of afebrile seizures or any history suggested the epilepsy * history of previous brain insults; cns infection, birth trauma, traumatic brain injury. * delayed developmental milestones * abnormal neurological examinations * currently treatment by continous antiepileptic drug(s) * a contraindication to clonazepam, diazepam such as drug hypersensitivity, liver disease. * predictable lack of available of follow up.

Keywords: recurrent febrile convulsions clonazepam prophylaxis
endometrial sampling (pipelle)in ivf patients

Conditions: Infertility

Summary: a prospective cross-over randomized study aimed to test the hypothesis that local injury of the endometrium increases the implantation rate in the successive cycle. seventy ivf patients will be randomly selected to undergo either endometrial biopsies or minimal cervical scratch on days 8-10 and 21-23 of their cycle, preceding the ivf treatment. if not pregnant, the women will continue for another ivf cycle, preceded by endometrial or cervical scratch complimentary to their procedure in the first cycle. the main major outcomes will include pregnancy rate, implantation rate, endometrial thickness, abortion rate, live births and embryo quality.


Eligibility criteria:
inclusion criteria: * women undergoing ivf treatment * repeated implantation failure exclusion criteria: * pid or suspected pid * undiagnosed irregular bleeding
effects of various types of ultrasound therapy in hip osteoarthritis

Conditions: Hip Osteoarthritis

Summary: this study evaluates the effects of various types of ultrasound therapy: continuous, pulsed, sham ultrasound and ultrasound combined with electrotherapy in patients with hip osteoarthritis. beside ultrasound therapy, patients received usual physiotherapy (balneotherapy, exercise and massage) either.

during ultrasound therapy electrical energy is converted into mechanical energy and heat. it has physical, chemical and biologic effects, like thermal effect, micro-massage, increased tissue metabolism, capillary permeability and tissue healing. continuous or pulsed forms can be applied. as pulsed ultrasound therapy has no thermal effect, greater intensity can be used. it can alleviate acute pain and inflammation. continuous ultrasound is usually used in chronic musculoskeletal diseases, in case of limitation of joint motion because its thermal effect. ultrasound can be combined with electrotherapy, when the effects of the two modalities are summed up.

Eligibility criteria:
inclusion criteria: * patients over 18 years of age with moderate hip osteoarthritis (radiologically kellgren- laurence ii-iii. stage) * chronic hip pain (for at least 8 weeks) * pain intensity is ≥ 50mm on a visual analogue scale * no physiotherapy or local injection (steroid, hialuronic acid) within 3 months before starting the study exclusion criteria: * acute hip pain (duration is less than 8 weeks) * steroid, hialuronic acid injection into the hip joint within 3 months * physiotherapy of the hip within 3 months * inflammatory hip osteoarthritis * infection * fever * tumour * epilepsy * pregnancy * untreated hypertension * heart failure (nyha ii-iv. stage) * inflammatory rheumatic diseases * hip arthroplasty * pacemaker or intracardiac device * severe osteoporosis * osteomyelitis

Keywords: hip osteoarthritis sonotens pulsed ultrasound continuous ultrasound
continuous adductor canal block for total knee arthroplasty analgesia

Conditions: Neuromuscular Blockade; Pain Management

Summary: the purpose of the study is to determine whether the association of sciatic nerve block to continuous adductor canal block is effective in the treatment of total knee arthroplasty post operative pain .


Eligibility criteria:
inclusion criteria: * elective unilateral tka, * planned continuous spinal anesthesia , * ability to follow study protocol, * american society of anesthesiologists class 1 to 3. exclusion criteria: * contraindication for neuraxial anesthetic, * chronic opioid use (defined as daily or almost daily use of opioids for \>3 months), * hypersensitivity and/or allergies to any of the study medications, * intraoperative use of volatile anesthetics, * preexisting neuropathy on the operative limb, * contraindications to a femoral, adductor canal or tibial nerve block.

Keywords: analgesia nerve block total knee replacement
lock solutions for epicutaneo-caval catheters in neonates: a "loosen" pilot study

Conditions: Catheter-related Bloodstream Infection; Preterm; Catheter Infection; Catheter Complications

Summary: epicutaneo-caval catheters (eccs) are widely used in neonatal intensive care units (nicus). they are small catheters inserted via superficial veins of the limbs or scalp using direct vein visualization the pathogenic microorganisms colonized inside catheters can easily form a bacterial biofilm and eventually spread with blood flow which causes bloodstream infection. many authors have studied the antibiotic-lock therapy (alt) in which a high-dose antibiotic solution is dripped and maintained in the catheter cavity for a certain period and can dissolve the biofilm formed on the wall to reduce the colonization of the bacteria and kill the embedded bacteria.the aim of the study is to evaluate the patency of the epicutaneo-caval catheter after its closure for 1 hour.


Eligibility criteria:
inclusion criteria: all the epicutaneo-caval catheter that need to be removed electively will be included in the study - exclusion criteria: all the epicutaneo-caval catheters removed not electively but for infectious or mechanical complications will be excluded from the study. -
intrathecal morphine vs. intrathecal morphine and regional anesthesia after cesarean section.

Conditions: Post-operative Pain

Summary: the objective of the study is to optimize post-operative analgesia and improve patient satisfaction while reducing total opioid consumption after cesarean section


Eligibility criteria:
inclusion criteria: * able to consent * bmi\<35 exclusion criteria: * adults unable to consent * bmi\>35 * individuals \<18 years of age at time of admission * individuals taking anticoagulant medications * significant co-morbid disease of pregnancy (including: gestational diabetes and significant abnormal placentation) * pre-existing chronic pain or pain disorder diagnosis * conversion from neuraxial to general anesthesia * prisoners

Keywords: erector spinae plane block