Kornimate/medical-research-clean huggingface dataset:
prediction of functional outcomes from chronic critical illness

Conditions: Chronic Critical Illness; Prolonged Mechanical Ventilation

Summary: the purpose of the study is to establish clinical determinants of poor cognitive and physical functional outcome of cci patients so that the investigators may develop and validate a multi-dimensional clinical prediction model to more effectively inform decision making earlier in the course of the icu care. the investigators hypothesize that multiple premorbid and acute factors measured early in the course of cci will have strong independent associations with functional recovery. the investigators further hypothesize that social and economic factors are associated with long-term functional outcomes independent of the acute clinical problems.

a substantial number of critically ill patients experience persistent organ failure leading to chronic critical illness (cci). the majority of these patients die within a year, and many survivors must cope with long-term physical and cognitive limitations that are often severe. survival with severe physical and cognitive dysfunction is a significant clinical, emotional, and economic burden in this population, but little is known about which patients are at highest risk for physical and cognitive dysfunction. moreover, although long-term mortality in cci can be reliably estimated with a validated mortality prediction model, there is currently no validated method to predict long-term functional disability for purposes of shared decision-making and resource planning. in order to address these gaps in knowledge, the investigators will conduct a multi-center prospective cohort study that measures clinical and premorbid risk factors for long-term physical and cognitive dysfunction in cci. using these risk factors, the investigators will construct a multi-outcome prognostic model for survival with severe physical or cognitive dysfunction to facilitate shared decision-making and resource planning. additionally, the investigators will identify independent social and economic variables that are risk factors for long-term survival and functional disability.

Eligibility criteria:
inclusion criteria 1. patients in enrolling icu 2. expected to require 7 days of mechanical ventilation uninterrupted for 72 hours for acute illness. 3. adults \>/= 18yo of age. exclusion criteria 1. patients with respiratory failure due to neuromuscular disease 2. patients with respiratory failure due to severe burn 3. patients requiring chronic mechanical ventilation at home 4. patients receiving mechanical ventilation at an outside hospital \>7 days 5. expected death prior to day 8 of mechanical ventilation therapies in 24 hrs. 6. prisoners 7. no family member or surrogate available 8. patient not proficient in english (or spanish at select sites) 9. unwilling or unable to provide written informed consent (patient or when indicated, by surrogate) 10. co-enrollment in another study not approved

Keywords: prognosis critical illness ventilation, mechanical disease attributes socioeconomic factors activities of daily living cognition
a non interventional study with paclitaxel onkovis (paclitaxel) utilized for the treatment of cancer

Conditions: Carcinoma

Summary: the main purpose of this observational study with paclitaxel is to determine the number of treatment cycles and the quantity of paclitaxel onkovis needed therefore under the special circumstance of ambulant chemotherapy. onkovis aims an economical utilization of the chemotherapeutics.the provision with adapted packaging sizes as to decrease the excess quantity to be discarded follows also this objective. secondary objectives are the survey of the side effects of paclitaxel onkovis in comparison to docetaxel. to this purpose, data regarding co medications and adverse events are also collected.


Eligibility criteria:
inclusion criteria: * indication for paclitaxel according to the smpc and treating physician exclusion criteria: * according to the paclitaxel smpc

Keywords: carcinoma breast cancer non-small cell lung cancer ovarial cancer ambulant chemotherapy treatment cycles paclitaxel paclitaxel onkovis quantity of paclitaxel packaging sizes
conservative versus aggressive discectomy for primary disc herniation with radiculopathy

Conditions: Herniated Disc

Summary: summary: this is a prospective randomize study to compare conservative and aggressive discectomy for treatment of disc herniation with radiculopathy. study hypothesis: the investigators believe that conservative discectomy could preserve a higher disc space and has a better long-term outcomes.

objectives:to compare the effect of two type surgery(conservative discectomy and aggressive discectomy)on disc herniation with radiculopathy after long-term follow-up. methods:the patients who were confirmed suffer from disc herniation with radiculopathy and failed to nonsurgical treatment will be divided into two groups, and will be follow up 3\~6 years for seeking the effect on disc space preservation and recurrent. outcome measures:the rate of pain release and patients satisfaction were measured by sf-36,odi,vas,score post-op. the height of disc was measured on x-ray film by the end point.

Eligibility criteria:
inclusion criteria: * duration of symptoms: 6 or more weeks. * treatments tried: non-steroidal anti-inflammatory medical therapy and physical therapy. * surgical screening: persistent radicular pain provoked by moderate exercise, sitting, increased abdominal pressure, decreased mobility, list (scoliosis), straight leg raising. * tests: mri to confirm diagnosis and level(s). exclusion criteria: * previous lumbar spine surgery. * not a surgical candidate for any of these reasons: overall health which makes spinal surgery too life-threatening to be an appropriate alternative, dramatic improvement with conservative care, or inability (for any reason) to undergo surgery within 6 months. * possible pregnancy. * active malignancy: a patient with a history of any invasive malignancy (except non-melanoma skin cancer) is ineligible unless he or she has been treated with a curative intent and there has been no clinical signs or symptoms of the malignancy for at least 5 years. * current fracture, infection, and/or deformity (greater than 15 degrees of lumbar scoliosis, using cobb measure technique) of the spine. * age less than 18 years. * cauda equina syndrome or progressive neurological deficit (usually requiring urgent surgery). * unavailability for follow-up (planning to move, no telephone, etc.) or inability to complete data surveys. * symptoms less than 6 weeks. * patient currently enrolled in any experimental "spine related" study.
observing patients with palliative asymptomatic centrally located advanced non-small cell lung carcinoma (nsclc)

Conditions: Non-small Cell Lung Carcinoma

Summary: the aim of the study is to assess current practice within prop \& lung teams, for treating asymptomatic patients with centrally located non-small cell lung cancer (nsclc), and to observe outcomes for those patients receiving immediate or deferred rt. this is a prospective cohort trial. patients will be managed by immediate radiotherapy (rt) or a deferred approach according to physicians' individual current clinical practice. baseline and follow-up data collection will be structured to focus on patient-reported measures to describe clinical outcomes in the two management groups. indications for prescribing rt and dose fractionation schedules will also be collected. a new intervention will not be introduced during this trial. instead, a follow-up regimen will be offered to both groups of patients, so that rt can be offered to the deferred group of patients if/when symptoms develop, and we can monitor symptoms/toxicities and qol in both groups of patients.


Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed nsclc * central disease, as defined by tumour (either primary or nodal disease) arising or extending within a 2cm circumferential expansion from the centre of the trachea or within the zone of the proximal bronchial tree * disease is visible on thoracic ct (diagnostic or simulation) * asymptomatic from intra-thoracic tumour (may have background chest symptoms related to underlying coad etc, but these symptoms must not have worsened due to tumour) * patient (due to age or co-morbidities) or tumour (due to locally advanced or metastatic disease) is not suitable for radical treatment (defined as surgery or rt dose \>50gy in 20 fractions or equivalent). * previous chemotherapy, thoracic rt or surgery is allowed * rt to other metastases (e.g. brain, bone etc) is allowed •≥ 18 years of age * able to provide written informed consent exclusion criteria: * intra-thoracic disease is peripheral only, not extending within 2cm of trachea/proximal bronchial tree * symptomatic from intra-thoracic nsclc * histological diagnosis of small cell lung cancer, or malignant mediastinal lymphadenopathy from another malignancy (not nsclc)

Keywords: palliative treatment advanced non-small cell lung cancer patients with asymptomatic centrally located advance nsclc who are palliative
high-frequency oscillatory ventilation (hfov) in preterm infants with severe respiratory distress syndrome (rds)

Conditions: Respiratory Distress Syndrome

Summary: respiratory distress syndrome (rds) is common in preterm infants born at less than 32 weeks gestation; surfactant and mechanical ventilation have been the standard treatment. however, despite advances in neonatal respiratory care, a considerable number of preterm infants develop chronic lung disease, termed bronchopulmonary dysplasia (bpd), which is associated with neonatal death, prolonged neonatal intensive care stay, and impaired neurodevelopment. high-frequency oscillatory ventilation (hfov) was developed as a new ventilation technique in the late 1970s. it was expected to result in less bpd and death as a primary model of ventilation compared to conventional ventilation (cv) in the treatment of rds. however, there is disagreement concerning the advantage of hfov over cv in the treatment of rds in preterm infants regarding the prevention of death, bpd, intraventricular hemorrhage, and periventricular leucomalacia in the short term. the purpose of this study was to compare the efficacy and safety of hfov and cv in preterm infants with severe rds.

all patients were monitored including blood pressure, heart rate, oxygen saturation, ventilator settings, and arterial blood gases pre- or during mechanical ventilation. pao2/fio2 was calculated. after 2 hours ventilation, if pao2/fio2 \<200, patients were given rescue surfactant therapy (curosurf 200mg/kg). a subsequent dose (100mg/kg) was administered when pao2/fio2 \<200 12 hours after the previous dose. surfactant was administered with use of in-line catheters. suctioning was performed 6 hours after surfactant administration, except for some patients needed suction soon, with use of an in-line suction catheter. ventilation continued during the administration of surfactant and suctioning.

Eligibility criteria:
inclusion criteria: 1. preterm infants admitted to the nicu with gestational age \<32 weeks, birth weight \<1500g and less than 24 hours of age 2. who developed rds requiring mechanical ventilation 3. presented a partial pressure of oxygen (pao2): fraction of inspired oxygen (fio2) ratio \<200 4. radiograph criteria of severe rds exclusion criteria: 1. infants with genetic metabolic diseases 2. congenital abnormalities 3. pneumothorax 4. grade iii-iv intracranial hemorrhage

Keywords: high-frequency oscillatory ventilation respiratory distress syndrome preterm infants neurodevelopment preterm infants with severe respiratory distress syndrome
new-des vs bms in svg -1 year outcomes

Conditions: Coronary Artery Disease

Summary: data regarding the efficacy of the percutaneous coronary intervention (pci) with new-designed drug-eluting stent (new-des) vs. bare metal stent (bms) of saphenous vein grafts (svg) stenosis is scarce. the primary objective was to compare one-year clinical outcomes of pci in stenosis of svg using new-des vs. bms in a real-world population. we carried out a multi-center registry comparing new-des with bms in all consecutive patients undergoing pci of svg. the primary composite endpoint was major adverse cardiac and cerebrovascular events (macce) at 1 year.


Eligibility criteria:
inclusion criteria: * patients after cabg with significant svg stenosis referred for pci exclusion criteria: * patients who had both types of stents implanted in the same procedure * patients with the old-des * patients who had pci of other vascular territories during the same procedure

Keywords: percutaneous coronary intervention saphenous vein graft new generation drug-eluting stent bare metal stent
the role of point-of-care polymerase chain reaction in managing nosocomial pneumonia

Conditions: Nosocomial Pneumonia

Summary: the study compares a device that is used for the detection of bacteria and mdr pathogens from skin, soft tissue and nose with the gold-standard (microbiological lab). it is a novel use for this device because it has been used in samples from the lower-respiratory tract.

the purpose of this study is to find out if a poc-pcr device can be use in the diagnosis of hospital acquired pneumonia and ventilation-associated pneumonia.

Eligibility criteria:
inclusion criteria: * patients that are admitted for at least 48 hours * radiological findings typical for pneumonia * signs of infection exclusion criteria: * patient or patient relatives doesn't accept to enter the study

Keywords: polymerase chain reaction
association between pre-op non-selective beta-blockers and hepatocellular carcinoma recurrence post-liver transplant

Conditions: Hepatocellular Carcinoma Recurrent; Hepatocellular Carcinoma

Summary: the goal of this observational study is to investigate the effect of non-selective beta-blocker (nsbb) on the recurrence of hepatocellular carcinoma (hcc) following liver transplantation in patients who underwent liver transplantation (lt) for treating hepatocellular carcinoma. the main question\[s\] it aims to answer are: * is the usage of non-selective beta-blocker associated with decreased recurrence of hepatocellular carcinoma following liver transplantation? * is the usage of non-selective beta-blocker associated with all-cause mortality following liver transplantation? researchers will compare the nsbb group, including patients who received non-selective beta-blocker therapy for at least 30 consecutive days within 3 months prior to liver transplantation more than 30 days prior, with the control group to to see if non-selective beta-blocker treatment is associated with decreased recurrence of hepatocellular carcinoma following liver transplantation.


Eligibility criteria:
inclusion criteria: * adult patients * underwent liver transplantation for treating hepatocellular carcinoma * between jan. 2008 - may. 2022 exclusion criteria: * pediatric patients (age under 18 years) * re-transplantation * multi-organ transplantation
evaluation of the vi polysaccharide vaccine against typhoid fever

Conditions: Typhoid; Paratyphoid Fever

Summary: this study is part of the international vaccine institute's (ivi's) typhoid vi demonstration project that aims to accelerate the rational introduction of vi vaccines in typhoid endemic countries. the purpose of this study is to determine the effectiveness of the vi vaccine following a mass typhoid immunization campaign in an endemic area in kolkata, india. the cost-effectiveness of the vi vaccination and the logistic feasibility of a mass typhoid immunization campaign will also be evaluated.

typhoid fever is a major cause of morbidity worldwide. the disease predominantly affects school-aged children, is more prevalent in urban areas, may last for several weeks and can lead to serious complications. management of this disease is further complicated by the emergence of multi-drug resistant strains. vaccination of high risk populations is considered the most promising strategy for the control of typhoid fever. the vi polysaccharide vaccine has been targeted for accelerated introduction into public health programs since it has been shown to have consistent efficacy results even in areas of high typhoid incidence, is given as a single dose, lacks patent protection and requires less strict cold chain requirements. this project attempts to evaluate a new vaccination strategy for residents of endemic areas. a cluster-randomized trial involving the vi polysaccharide vaccine and an active control (hepatitis a) was designed to determine the effectiveness and the feasibility of providing vi vaccine under actual programmatic conditions in 2 contiguous urban wards in kolkata. the vaccines used in this study are internationally produced and locally licensed. a 1 year pilot phase will precede the actual vi-demonstration project. surveillance for typhoid fever cases will continue after the mass immunization campaign. a passive surveillance system to evaluate adverse events following immunization will be implemented. socio-economic studies will be conducted in parallel to the effectiveness evaluation. the knowledge, attitudes, beliefs and practices among parents and health care providers regarding typhoid illness, treatment and prevention will be assessed. logistic, feasibility and vaccine costs will also be determined.

Eligibility criteria:
inclusion criteria: * registered in the project census * age \>=2 years * provide informed consent to receive vaccine exclusion criteria: * fever (\>37.5 degrees celsius) * pregnancy * lactating

Keywords: salmonella typhoid vaccine enteric fever
a realworld study of acute respiratory distress syndrome in china

Conditions: Acute Respiratory Distress Syndrome

Summary: ards is a critical respiratory disease caused by endogenous and exogenous factors. the mortality of ards varies from 30 to 70%. in 2012, a new international diagnostic criterion has been put forward. yet, its feasibility, reliability and validity need to be tested. meanwhile, the correlation of different severity and prognosis remains unclear. as so far, the epidemiological information about ards in china is lacking. investigators plan to conduct a multi-center observational study（real-life study） to investigate the risk factors, morbidity, management and prognosis of ards in china, in order to facilitate standardization of diagnosis and management of ards and provide basic data and idea for further clinical intervention studies.


Eligibility criteria:
inclusion criteria: * ≥18 years of age; hospitalized patients with main diagnosis as ards. exclusion criteria: * \<18 years of age * patients or their families refused to participate in the study * patients diagnosed as copd, pulmonary fibrosis or bronchiectasis

Keywords: acute respiratory distress syndrome epidemiology clinical features management prognosis
biofeedback for second stage of labor

Conditions: Labor Long; Labour;Obstructed

Summary: the purpose of this study is to examine whether transperineal ultrasound as visual biofeedback can be used during labor as an effective tool for shortening the second stage of labor and reducing the need for instrumental delivery, in a prospective randomized design.

biofeedback provides patients with better control of their body and their physiological reactions respective of the examined process, such as stress/anxiety, sports activity, labor, etc. women under epidural anesthesia, may frequently feel lack of control over the birthing process and difficulty in bearing down effectively, which is a very significant part of the second stage of labor. transperineal ultrasound during labor is a standard procedure in many medical centers in the world, mainly used to assist obstetricians in evaluating the progress of labor, fetal head position and assessing the chances of successful operative delivery. one of the most common tools used in transperineal ultrasound in measurement of the angle of progression, which has been suggested as a subjective method for assessing fetal station and for predicting successful vaginal delivery. a preliminary non-randomized study raised the possibility that the use of transperineal ultrasound during labor as a biofeedback tool may shorten the second stage of labor. the purpose of this study is to examine whether this tool can be used during labor as an effective tool for shortening the second stage of labor and reducing the need for instrumental delivery, in a prospective randomized design.

Eligibility criteria:
inclusion criteria: 1. first labor 2. full dilation 3. head position between sp-1 and sp+2. 4. epidural anesthesia 5. no contraindication for vaginal delivery 6. parturient informed consent exclusion criteria: 1. participation in parallel studies. 2. category iii fetal monitoring requiring immediate delivery.

Keywords: biofeedback second stage of labor operative delivery transperineal ultrasound
breast cancer 2-prevent translational center of excellence (tce) - metastatic markers of recurrent tumor phenotype for breast cancer

Conditions: Women With Suspected or Confirmed Recurrent Breast Cancer

Summary: this is a cohort study of women with suspected or confirmed recurrent breast cancer, with accessible tumor by standard clinical biopsy, prior to starting a new therapy for recurrent metastatic disease. study participants will be ascertained from the population of all persons greater than eighteen years of age receiving care at the clinical practices of the rowan breast center (rbc) at the university of pennsylvania. the overarching goal of this study is to identify the genetic and molecular markers of molecular evolution identified in patients who have progressed from a primary diagnosis of breast cancer to recurrent, metastatic disease. as an observational study, this study seeks to gather data regarding the molecular and genetic changes that a primary cancer undergoes as a patient's cancer recurs and ultimately progresses. we anticipate enrolling 600 women with recurrent breast cancer who meet eligibility requirements for this study. participation in this study will include the following: a biopsy and blood collection, completion of the study questionnaire, an optional bone marrow aspiration, and repeat collection of blood, offer of a research biopsy and a optional bone marrow aspirate collection at each progression time point. the study participants' medical information will be updated and changes in disease status will be captured on a regular basis.


Eligibility criteria:
inclusion criteria: * histologically-confirmed breast cancer - based upon pathology report of the primary or metastatic diagnosis * recurrent breast cancer (local, regional, or distant disease) - as determined by either clinical,radiological, or pathological evaluation * willing to undergo or provide tissue from a recent biopsy of recurrent tumor for both clinical and research testing * willing to undergo blood specimen collection * age 18 or over and are able to give informed consent exclusion criteria: * non-metastatic breast cancer (stage i, ii or iii) * anticoagulation that cannot be interrupted for the purpose of study evaluation (patients must have normal inr and ptt at the time of study biopsy)
innovative spinopelvic solutions with real-world evidence

Conditions: Sacroiliac Joint Dysfunction; Sacroiliac Joint Pain

Summary: inspire is a prospective decentralized study evaluating post-operative health outcomes in patients who undergo a procedure using implants manufactured by si-bone.


Eligibility criteria:
inclusion criteria: 1. age \> 21 at time of screening. 2. patient will undergo a procedure utilizing an ifuse implant family product. 3. patient is comfortable communicating in written and spoken english. 4. patient is willing and able to complete study questionnaires online, using either a smartphone, tablet, or computer. 5. patient is willing and able to provide informed consent to participate exclusion criteria: 1. patient has fibromyalgia. 2. patient has a pain pump. 3. patient is currently receiving or seeking worker's compensation, disability remuneration, and/or involved in injury litigation