Kornimate/medical-research-clean huggingface dataset:
lactose intolerance in infants with gastrointestinal disturbances

Conditions: Lactose Intolerance

Summary: this study enrolled thirty infants who presented by git symptoms and their comiss was ≥ 12. the patients were assessed upon presentation, after 2 weeks of receiving lactose free diet regimen and 2 weeks after rechallenging them with lactose. assessments of infants included anthropometric measurements, comiss estimation, neonatal/infant pain scale (nips) and pediatric quality of life assessment (peds ql). the study aims to detect the frequency of infants with li with positive cow's milk-related symptom score (comiss) (which could lead to misdiagnosis as cmpa) and validate of this score to be used as a screening tool for li in infants.


Eligibility criteria:
inclusion criteria: * artificially fed infants. * presented with git symptoms such as vomiting, diarrhea, abdominal pain, discomfort and distention. * cow's milk-related symptom score (comiss) of 12 or higher. exclusion criteria: * infants with positive family history of cow's milk protein allergy cmpa. * any allergic diseases. * history of anaphylaxis. * atopic dermatitis, swelling of lips or eyelids, urticaria or wheezy chest.
ultracet (tramadol hydrochloride and acetaminophen) for the treatment of rheumatoid arthritis pain.

Conditions: Arthritis, Rheumatoid

Summary: the purpose of this study is to assess the effectiveness of ultracetâ® (a combination analgesic) as add-on therapy in rheumatoid arthritis patients taking an nsaid (e.g. advilâ®, motrinâ® or other nonsteroidal anti-inflammatory drug) or a cox-2 inhibitor (e.g. celebrexâ®).

this is a randomized, multicenter, placebo-controlled, double-blind study to evaluate the efficacy and safety of ultracet® (tramadol 37.5 mg and acetaminophen 325 mg) as add-on therapy in rheumatoid arthritis patients taking an nsaid or a cox-2 inhibitor. the patients will be randomized into 2 treatment groups: the first group will receive one ultracet® tablet 3 times per day for 7 days. the second group will receive one placebo tablet 3 times per day for 7 days. the primary efficacy measurement will be the patients' average daily pain score. safety will be monitored throughout the study. the study hypothesis is that ultracet® will be well tolerated and the average daily pain relief score for the ultracet® treatment group will be better than that of placebo group. patients will take one ultracet® tablet or placebo by mouth 3 times per day, for 7 days.

Eligibility criteria:
inclusion criteria: * patients diagnosed with rheumatoid arthritis at least 6 months before the participation in the clinical trial, (defined by having more than 4 of the diagnosis criteria suggested by american college of rheumatology (acr * 1987)) * have been on a stable daily dose of an nsaid or a cox-2 inhibitor for at least 30 days prior to the start of the study * have arthralgia (arthritis pain in the joints) for at least 2 days before the entering clinical trial, with a pain score on the visual analogue scale (vas) of 40 mm or greater. exclusion criteria: * have had an inadequate response to tramadol hcl therapy, or have discontinued tramadol hcl therapy due to adverse events * have taken tramadol hcl within 30 days prior to study entry * have recently taken other medications for pain relief, (other than their daily nsaid or cox-2 inhibitor * daily use of aspirin at a dose greater than 100 mg per day.

Keywords: rheumatoid arthritis nsaid add-on therapy tramadol acetaminophen
treatment study of carnosine versus placebo in gulf war illness (gwi)

Conditions: Persian Gulf Syndrome

Summary: the purpose of this study is to perform a randomized double-blind, placebo-controlled, 12 week study of the effects of carnosine on cognitive, psychometric, autonomic, and muscle strength outcomes in 100 gwi subjects.

background: homocarnosine (beta-alanine - gamma-aminobutyric acid) is one of the most abundant dipeptides in the brain. it has important antioxidant properties. both beta-alanine and gaba are neurotransmitters, suggesting that cleavage of this dipeptide by carnosine dipeptidase 1 (cndp1) may have important regulatory functions in vivo. drug: homocarnosine is not available. carnosine (beta-alanine - histidine) is an over-the-counter dietary supplement that shares the antioxidant properties. we proposed that oral carnosine would be absorbed from the gut, cross the blood brain barrier, reduce presumed brain oxidant stress that participated in illness pathology, and improve subject health. hypothesis: carnosine supplementation for 12 weeks by mouth in gulf war illness subjects would improve cognitive and other outcomes compared to placebo treatment. subjects: gulf war illness subjects met 1996 fukuda criteria for chronic multisymptom illness. design: pilot study. double blind randomized placebo controlled with comparisons between week 0 (baseline, pre-randomization) and week 12 (end of study) outcomes: this pilot study included included cognitive testing, magnetic resonance imaging during the 2-back working memory task, self-report of psychometric and other subjective symptoms, tenderness testing by dolormetry, and pain threshold to assess reproducibility in the placebo-treated subjects, and potential treatment effects in the active study drug subjects. the study and each of the outcomes at weeks 0 and 12 are described in detail in the final published paper and in its extensive supplementary on-line materials (baraniuk jn et al. glob j health sci. 2013 5:69-81. pmid:23618477 pmcid:pmc4209301). an improvement on accuracy on the 2-back working memory task between 0 and 12 weeks was the primary outcome. other evaluations were secondary outcomes.

Eligibility criteria:
inclusion criteria: * evidence of military enlistment between august 1, 1990 and july 31, 1991, and deployment for 30 consecutive days to: * persian gulf waters and adjacent land areas, * other global locations, or, * u.s. only. 1990-1991 enlistment status: * active duty * national guard * reserves exclusion criteria: * hiv/aids * pregnant women * active duty military personnel * children * incarceration

Keywords: carnosine antioxidant persian gulf war gulf war syndrome gwi gulf war illness exercise chronic fatigue fibromyalgia veterans irritable bowel syndrome migraine headaches neuropathy multiple chemical sensitivity
serum squamous cell carcinoma antigen level and tumor volume in head and neck cancer

Conditions: Head and Neck Cancer

Summary: correlation between serum squamous cell carcinoma antigen level and tumor volume in head and neck cancer is to determine a correlation between level of serum squamous cell carcinoma antigen and tumor volume in head and neck caner measured by cross-sectional imaging.

the study is a cross-sectional study. a single measurement of serum squamous cell carcinoma antigen level is performed in the eligible head and neck squamous cell carcinoma patients. the study tool measuring serum squamous cell carcinoma antigen level is architect scc (abbott). the gross tumor volume in the cross sectional imaging obtained within 2 weeks of each patient is calculated with the typical ellipsoid formula. correlation between both parameters will be determined.

Eligibility criteria:
inclusion criteria: * histologically proven squamous cell carcinoma in head and neck * getting a cross-sectional imaging of head and neck within 2 weeks of collecting serum squamous cell carcinoma antigen exclusion criteria: * metastatic disease * accompanied non-head and neck squamous cell carcinoma * nasopharyngeal, thyroid, salivary, nose and paranasal sinus carcinoma * skin disease: eczema, erythrodermic epidermitis, pemphigus, and psoriasis * pulmonary disease: tuberculosis, adult respiratory distress syndrome, pulmonary infiltration with eosinophilia, sarcoidosis, and bronchogenic cyst * renal failure * using antihistamine eye drops

Keywords: serum squamous cell carcinoma antigen tumor volume head and neck cancer
sofia rsv fia field study

Conditions: Respiratory Syncytial Virus

Summary: the objective of this study is to demonstrate the clinical performance of the sofia rsv fia with specimens from symptomatic pediatric subjects who are less than nineteen (19) years of age.


Eligibility criteria:
inclusion criteria: 1. male or female 2. children less than nineteen (19) years of age can participate (assuming appropriate consent is obtained). 3. must currently be exhibiting symptoms characteristic of respiratory syncytial virus (rsv) illness. 4. subjects must present with one or more of the following to be eligible for enrollment: * fever, ≥ 37.8º c (100º f) at present or within past 24 hours * moderate to severe runny nose\* * moderate to severe congestion\* * decreased appetite * coughing * sneezing\* * wheezing * irritability * decreased activity * labored breathing exclusion criteria: 1. subjects nineteen years of age or older. 2. the parent or legal guardian is unable to understand and consent to participation. 3. current or prior treatment during this infection with anti-rsv synagis®.
improving arm and hand functions in chronic stroke (cihr 2012-2015)

Conditions: Stroke; Upper Extremity Paresis

Summary: improving arm and hand function after stroke has been difficult to achieve within the rehabilitation service provided in the acute stage often due to the limited resource in health care. while spontaneous recovery plateaus after 6 months, the prolonged disability affects quality of life and social participation in stroke survivors. this study is aimed at improving chronic motor impairment arm and hand impairment by providing the intervention with intensive training schedule. this study will compare two types of rehabilitation intervention using a randomized controlled trial. measurements also will be taken on various brain functions non-invasively to help discover how each of the intervention strategies works differently to repair the brain.

after unilateral stroke, incomplete recovery of arm and hand movement is common and its long-lasting negative effects include increased care giving costs and overall reduced quality of life. recent evidence suggests that a novel behavioral intervention could improve motor functions in sub-acute patients with added benefits in cognitive and brain functions. however few studies have addressed whether chronic stage patients can also benefit from the intervention and how brain plasticity works over the course of rehabilitation. this study will investigate the benefits of two types of intervention methods that are extendable for community-based intervention services in the future. it also will examine changes in integrity of motions before and after the intervention. further comparisons between brain functions and structure will be made using magnetoencephalography (meg) and magnetic resonance imaging (mri), non-invasively. these behavioural and physiological measures will inform the mechanisms of stroke recovery and training.

Eligibility criteria:
inclusion criteria: * post-acute stroke patients with unilateral first-time mca stroke sustained . (more than 6 months ago prior to the enrolment to the study). * patients' residual motor impairments in the affected hand and arm should be greater than stage 3 on the chedoke mcmaster scale. exclusion criteria: * patients with moderate apraxia, aphasia or dementia, and patients with severe sensory loss in the paretic hand, severe language-communication disability, posture problems, involuntary movements, high-blood pressure, depression or other psychological disorders, metal in body that interferes with meg and mri measurements.
gp vs tp in the treatment of advanced nasopharyngeal carcinoma in northwest china

Conditions: Nasopharyngeal Squamous Cell Carcinoma; Toxicity Due to Radiotherapy

Summary: the present study is a randomized, control, phase ii study of locally advanced nasopharyngeal carcinoma (npc) in northwest china treated with gemcitabine plus cisplatin regimen (gp) or docetaxel plus cisplatin regimen (tp) induction chemotherapy followed by concurrent chemoradiotherapy. the population consists of stage iii-ivb nasopharyngeal carcinoma (npc). the effectiveness, side effects and quality of life will be evaluated according to standard who response criteria, nci-ctc ae v3.0 and eortc qlq-c30 and h\&n35 questionnaire.

nasopharyngeal carcinoma has an unique geographic distribution, and has different pathological types, natural history, treatment modalities in endemic and non-endemic regions. nasopharyngeal carcinoma is both radiosensitive and chemosensitive. chemoradiotherapy is the main therapy choice for the locoregionally advanced nasopharyngeal carcinoma. however,the optimal chemoradiotherapy regimen has not been determined. many new drugs including docetaxel and gemcitabine have been incorporated in the induction chemotherapy phase of npc. the investigators designed the present study with induction chemotherapy follow by ccrt for locoregionally advanced npc in non-endemic northwest china, comparing induction chemotherapy regime of tp and gp. the primary objectives were overall response rate (orr), acute toxicity, tolerance; second objective were overall survival (os), progression free survival (pfs), rate of distant metastases,late adverse events and quality of life.

Eligibility criteria:
inclusion criteria: * histologically proven who ii\~iii native npc in northwest region of china; * 18 years to 70 years; * stages iii-ivb according to ajcc stage classification(7th edition), no previous chemotherapy and radiotherapy; * performance status: 0-1(ecog); * wbc \> 4.0x109/l, plt \> 100x109/l, with normal hepatic function(ast, alt \< 2.5 x upper limit of normal, and bilirubin \< 1.5 x upper limit of normal), with normal renal function (creatinine \< 1.5 x upper limit of normal); * ability to comply with trial requirements. exclusion criteria: * evidence of metastases by clinical or radiographic examinations; * history of malignancy; * prior chemotherapy or anticancer biologic therapy for any type of cancer, or prior radiotherapy to the head and neck region except for radioactive iodine therapy.; * patients with uncontrolled intercurrent disease; * patients with currently active malignancy; * pregnant or lactating women patients of childbearing potential who are unwilling to practice adequate contraception during study treatment and for two months after the last administration of study drug.

Keywords: advanced nasopharyngeal carcinoma treatment northwest china
intracranial pressure monitoring in moderate traumatic brain injury

Conditions: Moderate Traumatic Brain Injury

Summary: objectives the primary focus for scientific investigation is to conduct a multi-center observational study to determine if intracranial pressure (icp) monitoring to direct treatment of patients with moderate traumatic brain injury (tbi) improves medical practice and patient outcomes in china. design and outcomes this is a prospective observational cohort multi-center study with blinded evaluation of outcome. it is a 2-group design. neurologic outcome is evaluated by extended glasgow outcome score(gose) at 6 months. interventions and duration this is an observational study. the decision of intracranial pressure monitoring is made by the relatives of patient. management of all patients will be consistent with protocols presently being used in the study hospitals. for patients who received icp monitoring, the management will also be based specifically on the presence of intracranial hypertension. each patient will be evaluated at 6 months post injury on neurological outcomes. sample size and population 832 patients with moderate traumatic brain injury will be collected on this study.


Eligibility criteria:
inclusion criteria: * history of head trauma * 18 ≤ age ≤ 70 years * abnormal head ct scan (skull fracture, intracranial hematoma, brain contusion, cerebral infarction, brain edema, hydrocephalus, etc.) * glasgow coma scale at admission: 9-12 * arriving at hospital within 24 hours after injury * systolic blood pressure ≥100 millimeter of mercury * no pregnant exclusion criteria: * refusing follow up visit * penetrating head injury, spine or spinal cord injury * surgical treatment in other hospital before admission * cardiopulmonary resuscitation after injury or in need of blood transfusion due to active bleeding * consciousness disorder caused not by head trauma (alcoholism, drug overdose, etc.) * prior history of head trauma or stroke * multiple injuries, with severity score of other parts\>18 * rhabdomyolysis, with blood creatine kinase (ck)\>5000 international unit/l * injury of aorta, carotid artery or vertebral artery * serum creatinine (female)\>1.2mg/dl (106μmol/l), serum creatinine (male)\>1.5mg/dl (133μmol/l) * glomerular filtration rate (egfr) \<60 milliliter/min * body mass index (bmi) \ 40kg/m2 * estimated survival time less than 1 year * participating in other on-going clinical researches * other systemic diseases: uremia, liver cirrhosis, malignant tumor, mental illness, drug, or alcohol dependence, etc.

Keywords: intracranial pressure
digital, innovative, sustainable, and knowledge-based acute municipal healthcare services illness and trauma

Conditions: Multiple Chronic Conditions; Acute Disease

Summary: through introducing physicians in front in the medical assessment and decision-making processes in acute and sub-acute illness in the municipalities, as well as including machine learning in analyzing prospective and retrospective data, the project will develop and implement innovative and knowledge-based digital diagnostic tools and decision-making support systems to be used in the municipalities. as such, the project will contribute to early identification of severe illness, prevent deterioration of disease, and facilitate early medical intervention.

the overall objective of the project is to determine if and how innovative digital decision-making tools based on artificial intelligence (ai) can help to develop more accessible, efficient, cost-effective, and sustainable municipal healthcare services. more specifically, the project aims are: * to explore different outcomes of a municipal rapid response car manned with dedicated physicians * to compare outcomes from norwegian and swedish out-of-hospital ems in acute illness * to explore how decision-making tools based on ai can be used to optimize dispatch * to explore how decision-making tools based on ai can assist dispatched personnel and in prehospital care * to determine the quality and efficacy of the different systems explored through cost-analyses and exploration of stakeholders' experiences with the decision-making tools

Eligibility criteria:
inclusion criteria:all patients receiving services from the physician manned rapid response car - exclusion criteria:none -
quality of ventilation with facial versus nasal mask vs nasal mask anesthesia in children 3 to 12 years old

Conditions: Ventilation; Intubation Complication; Intubation; Difficult or Failed

Summary: in this single-blind clinical trial study, 70children who are candidates for lower abdominal elective surgery under general anesthesia presented at imam hossein hospital in isfahan will be included in the study and will be divided into 2 groups. in the first group, ventilation with facial mask and in the second group, ventilation with nasal mask will be done for three minutes. then the reduction in spo2 and the impossibility of ventilation of patients will be evaluated and compared between the two groups.


Eligibility criteria:
inclusion criteria: * age category between 3 to 12 years * candidate for lower abdominal elective surgery under general anesthesia * no obstruction in the nasal pathway * no deformity and fractures in facial * no acute or chronic lung disease exclusion criteria: * impossibility of airway oropharyngeal ventilation * impossibility of ventilation of the anatomical facial mask with neck extension * dissatisfaction with participating in the study.
the neuroprotection of sevoflurane preconditioning on intracranial aneurysm surgery

Conditions: Brain Ischemia

Summary: the current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery.

the current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery. the patients with cerebral aneurysm will be recruited in current study. the sevoflurane preconditioning will be performed before the surgical procedure. the neurological injury biomarkers, such as s-100b and nse will be detected. the neurological function and recovery will be assessed after the surgery.

Eligibility criteria:
inclusion criteria: * patient under intracranial aneurysm surgery. exclusion criteria: * patients who refused to participate or who had a history of chemotherapy/convulsions two weeks prior to admission, stroke/cardiopulmonary resuscitation/head trauma three months prior to admission, alzheimer's disease, amyotrophic lateral sclerosis, and prior melanoma were excluded.

Keywords: cerebral ischemia sevoflurane preconditioning intracranial aneurysm surgery
ultrasound guided intermediate cervical plexus block in thyroid surgery

Conditions: Postoperative Pain

Summary: studying the effect of dexmeditomidine addition to bupivacaine in bilateral intermediate cervical block for patients undergoing thyroidectomy under general anaesthesia

80 patients who will be undergoing elective thyroidectomy will be randomly allocated into one of two groups ; group a will receive 20 mg isobaric bupivacaine + 8 mg dexamethasone(diluted in 5 ml) group b will receive 20 mg isobaric bupivacaine + 1 ml normal saline. block will be done under complete a septic condition after induction of general anaesthesia.

Eligibility criteria:
inclusion criteria: * elective surgery * asa 1, ii, and iii exclusion criteria: * patient refusal * infection at the entry site * bmi \> 3
influence of proximal motor control in treating lateral epicondylitis

Conditions: Lateral Epicondylitis

Summary: this study will be conducted to investigate the effect of scapular muscles (lower trapezius, middle trapezius and serratus anterior) strengthening on pain, pain free hand grip strength and functional outcome added to conventional physical therapy in patients with chronic lateral epicondylitis.

this study will try to investigate if scapular muscles strengthening have an effective role on pain, pain free hand grip strength and function when added to conventional physical therapy in patients with le.

Eligibility criteria:
inclusion criteria: 1. symptoms of lateral epicondylitis from at least the past 3 months. 2. pain in at least two of the following four tests; tomsen test, maudsley test, mill's test and handgrip dynamometer test. 3. their ages range from 30-50 years old. exclusion criteria: subjects will be excluded from the study if they have: 1. peripheral neuropathy. 2. lesions of upper limb nerves. 3. history of surgery in the affected elbow 6 months ago. 4. cervical radiculopathy.