Kornimate/medical-research-clean huggingface dataset:
natural history of non-steroidal anti-inflammatory drug and non-helicobacter pylori in bleeding peptic ulcers

Conditions: Peptic Ulcer

Summary: the aim of this study is to study the natural history of the ulcer healing while on proton pump inhibitors (ppi) and the ulcer recurrence without acid suppression therapy of non-steroidal anti-inflammatory drugs (nsaid), non-helicobacter pylori (hp) bleeding ulcer patients.

non-steroidal anti-inflammatory drugs (nsaid), non-helicobacter pylori (hp) bleeding peptic ulcers are relatively common in the west (11%-44%). it is uncommon in hong kong (4%). significant number of these patients with non-nsaid, non-hp bleeding ulcers had co-morbid illness and many had life-threatening conditions. our recent study showed that there is an increasing incidence of non-steroidal anti-inflammatory drugs (nsaid), non-helicobacter pylori (hp) bleeding peptic ulcers. there is no datum on the natural course of these patients and this is our aim to have this observational study.

Eligibility criteria:
inclusion criteria: * patient has non-nsaid (non-steroidal anti-inflammatory drugs), non-helicobacter pylori bleeding peptic ulcer * age \> 18 years old * informed consent exclusion criteria: * concommitant use of high dose steroid or warfarin * new start on non-steroidal anti-inflammatory drugs or aspirin or cox2 inhibitors * renal failure (serum creatinine \> 200umol/l) * previous gastric surgery * oesophagitis, esophageal varices * terminal illness or malignancy

Keywords: non-nsaid non-hp bleeding peptic ulcer
testing the interactive effects of delta-9-tetrahydrocannabinol and pregnenolone

Conditions: Healthy

Summary: the overall purpose of this study is to examine the effect of pregnenolone (preg) on the acute psychosis-like and cognitive effects of delta-9-tetrahydrocannabinol (thc). this will be tested by pretreating healthy individuals with preg and then assessing their responses to thc.


Eligibility criteria:
inclusion criteria: * exposed to cannabis at least once in lifetime. exclusion criteria: * cannabis naive * individuals with a documented reaction/allergy to pregnenolone

Keywords: cannabis marijuana thc pregnenolone psychotic disorders preg
the clinical study of assessing her-2 expression in gastric cancer with extra tumor tissue paraffin blocks using immunohistochemistry

Conditions: Gastric Cancer Surgical Specimens,18-80 Years Old, at Least Two Tumor Tissue Blocks

Summary: background: gastric cancer (gc) is major global health concern and the second leading cause of cancer deaths worldwide. amplification of her2/neu gene and/or overexpression of the her2/neu protein have been observed in gc. trastuzumab (herceptin™) is an anti-her2/neu antibody, which has been successfully applied in gc. however, the intratumoral heterogeneity of her2/neu overexpression and amplification in gc should be noticed. the investigators investigated the significance of evaluating her2/neu expression in different paraffin blocks of tumor tissue in gc. methods: 2000 gc patients from ten centers, patients were divided into a cohort using one tumor tissue paraffin block (cohort 1, n=1000) and a cohort using dual tumor tissue paraffin blocks (cohort 2, n=1000) when evaluating her2/neu expression status by immunohistochemistry (ihc). in cohort 2, the investigators combined the results from two different paraffin blocks and used the higher one as the final score.


Eligibility criteria:
inclusion criteria: * undergone curative surgery of gastric cancer, * 18-80 years old. exclusion criteria: * none

Keywords: gastric cancer her2/neu dual paraffin blocks trastuzumab clinical prospective multicenter cohort study
faith-based african american cancer survivorship storytelling

Conditions: Cancer

Summary: the purpose of this research study is to evaluate the feasibility and acceptability of an intervention (viewing of video recordings) designed to reduce psychological distress among african americans during treatment for cancer. this knowledge will inform a larger test of an intervention.

this study addresses a need to integrate spirituality with cancer care as requested among african americans. in the pi's research with african americans, a dominant mental health promoting strategy used in response to a cancer diagnosis is the use of religious stories and songs. african americans have a strong cultural history of relying on religious stories and songs to overcome oppression and mental suffering encountered in their lived experience. if successful, the findings from this preliminary study will contribute to the evidence that spirituality is important to cancer care and to achieving optimal patient outcomes among this medically underserved population. more importantly, the infusion of spirituality in cancer care has to potential to reduce the high levels of psychological distress experienced among african americans and fcg's; to enable them to become more engaged in their cancer care and in supportive family relationships; and, ultimately to improve the overall quality of life for african american cancer patients and fcgs. the actual administration of the intervention (viewing of video recordings) will take approximately 30 minutes with all sessions to occur over a 3 week period. the intervention will consist of participants viewing a selection of video recorded vignettes during 3 weekly sessions. the vignettes are of actual african american cancer survivors narrating stories of ways in which hymns can be used to overcome their anxieties and depressed moods through the use of a hymn.

Eligibility criteria:
inclusion criteria for patients: * age 30-89 years * newly diagnosed with any stage cancer * treatment plans to include weekly outpatient chemotherapy * previously screened and with greater than 0 level of psychological distress * willingness to participate in all study activities including data collection * willing to identify a family caregiver (fcg) (immediate or extended family member) to also participate exclusion criteria for patients: * have completed surgery with no plans for chemotherapy * find conversations around religion or spirituality emotionally upsetting * have completed more than half of prescribed chemotherapy treatments * in hospice care * not able to provide informed consent inclusion criteria for family caregiver: * immediate or extended family member of the patient * 18 years of age or older * able to provide informed consent * willing to participate in study activities, including data collection exclusion criteria for family caregiver: * find conversations around religion or spirituality emotionally upsetting

Keywords: behavioral research social research spirituality late stage cancer
mobile clinic - a cross-sectional epidemiological survey

Conditions: Age Related Macular Degeneration

Summary: the aim of the study is to find out prevalence of aged-related macular degeneration (amd) in slovak republic. the outcome of the project will be epidemiology survey, prevalence of wet form of amd in relation to demographic data, patient´s anamnesis, nutrition, co-morbidities etc.

it´s cross-sectional epidemiological survey, multi-centric, non-interventional 1. patients will fill a questionnaire with demography data, anamnesis, risk factors. 2. patients will be assessed by using amsler grid. 3. patient´s back of the eye will be examined with fundus camera (searching for long-term back of the eye changes, retina vessels, macula and surrounding tissues) by retina specialist. 4. patient undergoes optical coherent tomography (oct) examination (cross-section of fovea and macula) by retina specialist. the project actively screen patients with wamd. all patients will sign an informed consent. the process of screening will be held in certain timeframe (cca. 2 months) and selected areas of slovak republic.

Eligibility criteria:
inclusion criteria: 1. adult patients (aged≥55 years) from selected areas in slovak republic 2. patients with home base far than 35 km from the nearest center (centers: bratislava, nitra, nové zámky, trenčín, bojnice, žilina, martin, ružomberok, banská bystrica, zvolen, poprad, prešov, košice, trebišov) 3. patient´s informed consent signed. exclusion criteria: * patients who do not meet the inclusion criteria

Keywords: wet amd epidemiology
individualized assessment of motor function and balance in intensive therapy

Conditions: Neurodevelopmental Disorders

Summary: the goal of this study is to assess the individualized use of technology to assess motor function and balance for ambulatory children participating in an intensive therapy episode of care and determine the effectiveness of the program. children 7-17 years old who can walk and are completing an intensive therapy episode of care will be recruited to participate in this study. demographic, health history, and pt,ot,st medical records will be collected. based on the participant's functional goals, motor function and balance tests will be selected including common balance tests (standing with eyes open, standing with eyes closed), walking, walking and turning, standing up and sitting down from a bench, reaction time, and step down. participants will be tested before, immediately after, 6 weeks after, and 12 weeks after the episode of care.

the goal of this study is to assess the individualized use of instrumented assessment of motor function and balance for ambulatory children participating in an intensive therapy episode of care and determine the effectiveness of the intervention. children 7-17 with neurodevelopmental diagnosis, gmfcs levels i and ii and completing an intensive therapy episode of care will be recruited to participate in this study. demographic, health history, and pt,ot,st medical records will be collected. based on the participant's functional goals, motor function and balance tests in single and dual conditions will be selected including romberg balance tests, walking, walking and turning, sit to/from stand, reaction time, and step down administered while participant is recorded using a portable measurement platform which incorporates a custom force plate, azure kinect spatial sensor, and interface board. participants will be tested before, immediately after, 6 weeks after, and 12 weeks after the episode of care. testing is estimated to last for 45 minutes.

Eligibility criteria:
inclusion criteria: * ambulatory children 7-17 years old receiving care in an interdisciplinary, intensive therapy program * gmfcs levels i and ii * able to follow 2-3 step directions * english speaking exclusion criteria: * orthopedic surgery in the past year or * significant visual impairment * significant hearing impairment.

Keywords: technology neurodevelopmental disorders pediatrics rehabilitation intensive therapy
brachytherapy in treating patients with prostate cancer

Conditions: Prostate Cancer

Summary: rationale: radiation therapy uses high-energy x-rays to damage tumor cells. giving radiation therapy through seeds implanted into the prostate may kill more tumor cells. purpose: phase ii trial to study the effectiveness of brachytherapy in treating patients with stage i or stage ii prostate cancer.

objectives: i. evaluate the effectiveness of transrectal ultrasound guided permanent radioactive implantation of the prostate in patients with confined adenocarcinoma of the prostate. ii. assess the overall survival, disease specific survival, clinical relapse (local or distant), psa levels, and genitourinary and gastrointestinal morbidity in these implant patients. iii. assess the quality of life of these patients. outline: this is a multicenter study. patients receive transrectal ultrasound guided radioactive i-125 seeds implanted into the prostate. at least one week prior to implant, patients undergo transurethral ultrasound study to determine the volume of prostate. following implantation, seeds that have extruded into the bladder or lodged in the urethral wall are retrieved, and extra seeds may be implanted into identified "cold spots" for uniform seed distribution. prostate rebiopsy is required before starting hormonal therapy for local progression or biochemical failure without clear focus of progression. quality of life is assessed every 3 months for 1 year, then every 6 months for 1 year, and then annually for 3 years. patients are followed every 3 months for 1 year, then every 6 months for 2 years, and then annually thereafter. projected accrual: a total of 95 patients will be accrued for this study within 1 year.

Eligibility criteria:
disease characteristics: histologically proven locally confined adenocarcinoma of the prostate stage i or ii (t1b-c or t2a-b, nx, m0) psa no greater than 10 ng/ml prostate volume by transurethral ultrasound no greater than 45/mm3 at least 1 week, but no more than 4 weeks, prior to implant gleason score no greater than 6 american urological association voiding symptom score no greater than 12 no evidence of distant metastases no lymph node involvement patient characteristics: age: not specified performance status: karnofsky 70-100% life expectancy: not specified hematopoietic: not specified hepatic: not specified renal: not specified other: no prior or concurrent malignancy within 5 years except basal or squamous cell skin cancer no major medical or psychiatric illness prior concurrent therapy: biologic therapy: not specified chemotherapy: no prior chemotherapy endocrine therapy: no prior hormonal therapy, including finasteride radiotherapy: no prior pelvic radiotherapy surgery: no prior radical surgery for prostate cancer (e.g., transurethral prostatectomy) no hip prosthesis

Keywords: stage i prostate cancer stage iib prostate cancer stage iia prostate cancer
ph 2/3 study in subjects with mpm to assess adi-peg 20 with pemetrexed and cisplatin

Conditions: Mesothelioma

Summary: this is a study of adi-peg 20 (pegylated arginine deiminase), an arginine degrading enzyme versus placebo in patients with malignant pleural mesothelioma. malignant pleural mesothelioma have been found to require arginine, an amino acid. thus the hypothesis is that by restricting arginine with adi-peg 20, the malignant pleural mesothelioma cells will starve and die.


Eligibility criteria:
inclusion criteria: * histologically proven unresectable mpm of biphasic or sarcomatoid histology * naïve to chemotherapy or immunotherapy * ecog ps 0-1 * expected survival of at least 3 months * age 18 years or over (there is no upper age limit) * measurable disease by modified recist criteria for mpm for local pleural disease and recist 1.1 criteria for metastatic lesions * written (signed and dated) informed consent and must be capable of co-operating with treatment and follow up * adequate hematologic, hepatic, and renal function exclusion criteria: * radiotherapy (except for palliative reasons) in the previous two weeks before study treatment * history of unstable cardiac disease * ongoing toxic manifestations of previous treatments * symptomatic brain or spinal cord metastases (patients must be stable for \> 1 month post radiotherapy or surgery) * major thoracic or abdominal surgery from which the patient has not yet recovered.

Keywords: malignant pleural mesothelioma
heart failure management program versus usual care

Conditions: Cardiac Failure; Congestive Heart Failure

Summary: heart failure (hf) patients discharged to skilled nursing facilities have higher rehospitalization rates and mortality than patients discharged to home. hf disease management programs have been shown to reduce rehospitalizations in community settings, no national guidelines have been set forth for skilled nursing facilities (snf). this study will investigate the the effect of a heart failure-disease management program on the outcome of all-cause hospital readmissions, emergency room admissions and mortality for 30 days post-snf admission using 7 component heart failure disease management program.


Eligibility criteria:
inclusion criteria: * heart failure is listed as the hospital discharge primary diagnosis * heart failure is listed as the hospital discharge secondary diagnosis exclusion criteria: * any life threatening condition which predicts mortality in 6 months or less

Keywords: skilled nursing facility heart failure transitional care
non-mesh repair of inguinal hernia: desarda versus darn

Conditions: Inguinal Hernia Repair; Inguinal Hernia

Summary: to compare the results of desarda and darn techniques in inguinal hernia repair in assiut university hospital.

inguinal hernia is one of the most common types of abdominal hernias with a prevalence of 75% of all abdominal hernias. inguinal hernia repair is one of the most encountered surgeries all over the world. the use of mesh for inguinal hernia repair is the most commonly applied technique. however, being a foreign body, mesh repair has its own disadvantages. these include postoperative hematoma and seroma, foreign body reaction, infection, mesh rejection, mesh migration, and fistula formation. moreover, the use of mesh in potentially contaminated operating field is not advisable. infectious complication and their consequences have restricted the use of mesh in emergency settings. in addition, mesh repair is not available in every part of the world since it increases the cost of the operation. therefore, the non-mesh repair of inguinal hernia has been recently revisited. different techniques for non-mesh inguinal hernia repair are available including bassini, shouldice, desarda and darn. in 2001,indian surgeon dr. desarda, introduced a novel technique of a tissue- based hernia repair without mesh with almost zero recurrence rates in which an undetached strip of the external oblique aponeurosis is sutured to the inguinal ligament below and the muscle arch above, behind the cord, to form a new posterior wall. external oblique muscle gives additional strength to the weakened muscle arch to keep this strip physiologically dynamic. in 1948, moloney described a suture inguinal herniorrhaphy in which two layers of continuous monofilament non-absorbable suture lines with no tension were inserted. the first suture line is between the lower edge of the internal oblique muscle/aponeurosis and the inguinal ligament. the second superficial layer is between the rectus sheath and the inguinal ligament. all sutures should be placed without tension but with no slack . literature are deficient in comparing desarda technique and darn technique in the repair of inguinal hernia.

Eligibility criteria:
inclusion criteria: * inguinal hernia * age more than 18 * male patients exclusion criteria: • simultaneous performance of other surgical procedures

Keywords: hernia desarda repair darn repair inguinal hernia
a prospective longitudinal collection of subjects diagnosed with small cell lung cancer

Conditions: Small Cell Lung Cancer

Summary: the purpose of this study is to collect samples to evaluate the progrp and nse assays independently as aids for monitoring the course of disease and therapy in subjects diagnosed with sclc.


Eligibility criteria:
inclusion criteria: * age ≥ 18 * confirmed diagnosis of sclc or mixed sclc/non-sclc per histopathology results * scheduled to undergo first-, second- or third-line treatment for sclc, including chemotherapy, chemotherapy + radiation therapy, or combined concurrent chemoradiotherapy. * able to understand and willing to provide informed consent exclusion criteria: * no diagnosis of sclc * not scheduled to undergo treatment for the diagnosis of sclc * unable to provide informed consent

Keywords: small cell lung cancer sclc lung cancer subjects diagnosed with sclc who will undergo treatment
cold therapy in the treatment of exercise-induced muscle damage

Conditions: Cryotherapy Effect

Summary: subjects were randomly placed in five groups: (1) single exposure at 5°c in cold water immersion, (2) single exposure at 15°c in cold water immersion, (3) multiple exposures at 10°c in cold water immersion, (4) whole body cryotherapy (wbc) at 110°c and (5) passive recovery (control group). the single exposure groups performed cold water immersion immediately after exercise-induced muscle damage (eimd) for 20 minutes. the multiple exposures group performed cold water immersion immediately, 24h, 48h and 72h after eimd (once a day) for 20 minutes. the wbc group remained in the cabin immediately after eimd for 3 min. the control group was not exposed to treatment after the eimd protocol. the subjects were asked to visit the laboratory on seven occasions. the first visit was the familiarization of the subjects with experimental procedures and their anthropometric assessment. one week after familiarization, on visit two, volunteers performed the exercise-induced muscle damage (eimd) protocol and they were allocated to one of experimental groups. indirect markers of muscle damage and inflammatory responses were evaluated at baseline (pre), immediately post, 24h, 48h, 72h, 96h, and 168h following the eimd protocol by measuring anterior thigh muscle swelling, isometric knee extensors peak torque, knee extensors muscle soreness, countermovement vertical jump and blood sample analyzes.

to avoid circadian influences, subjects were asked to visit the laboratory always at the same time of day. volunteers were asked to not perform any vigorous physical activities or unaccustomed exercise during the experiment period. in addition, they were instructed not to intake medications or supplements during the study.

Eligibility criteria:
inclusion criteria: * college students were eligible for inclusion. exclusion criteria: * exclusion criteria included a history of eccentric quadriceps exercise in the past 3 months * a history of quadriceps muscle tear * neurological disease involving the lower limbs * current lower-limb musculoskeletal injury and thigh skinfold thickness \>20 mm.. * participants with potential vascular problems which cold therapy is contraindicated (eg, diagnoses of diabetes or raynaud's disease) were also excluded

Keywords: exercise-induced muscle damage skeletal muscle injury recovery cryotherapy recovery of function rehabilitation