Kornimate/medical-research-clean huggingface dataset:
cervix monitor for detection conditions leading to spontaneous preterm delivery

Conditions: Preterm Birth

Summary: preterm birth is a leading cause of neonatal mortality despite of numerous advances and intensive research in perinatal medicine. almost one million children die every year due to the complications of preterm birth and rates are on the rise. of the 14 million survivors per year, most face a lifetime of disability, including learning disabilities, visual and hearing impairments. the majority of preterm birth happen spontaneously (sptd) which is often a multi factorial event, precocious cervical softening, shortening and dilatation are a common underlying factor. in the scope of this project the investigators propose to develop and clinically validate a new device, cervix monitor (cm), for detecting cervix conditions leading to sptd and its risk assessment.

sptd is closely related to a premature cervical ripening. the scientific basis for the proposed project is that the elasticity modulus of a cervix is a more sensitive parameter characterizing the stage of cervical ripening. the main component of the cervical tissue is collagen. cervical ripening is the result of realignment of collagen, degradation of collagen cross-linking due to proteolytic enzymes. these processes affect the elasticity modulus of the cervical tissue. therefore, assessment of cervix by a device (cm) measuring cervical elasticity (stiffness) and cervical length (effacement) appears to be an adequate approach for identifying pregnant women at high risk of sptd. the cm is based on measuring applied pressure to the cervix by a tactile sensor array (stress data) and ultrasound measurement of cervix length (strain data). tactile and ultrasound sensors are allocated on the tip of the measuring part of vaginal probe. the discovery of novel bio markers that could reliably identify women who will subsequently deliver preterm, may allow for timely medical intervention and targeted therapeutic treatments aimed at improving maternal and fetal outcomes.

Eligibility criteria:
inclusion criteria: * gestational age from 24 to 28 weeks at time of cervix monitor measurement * singleton in the current pregnancy exclusion criteria: * fatal anomaly * history of fetal reduction in the current pregnancy to the singleton gestation * preterm rapture of membranes * current or planned cervical cerclage * planned indicated preterm delivery * active known cancer of the colon, rectum wall, cervix, vaginal, uterus or bladder * ischemic heart disease and or arrhythmia * active skin infection or ulceration within the vaginal/vulva (herpes infection)
daoib for the treatment of mild cognitive impairment

Conditions: Mild Cognitive Impairment

Summary: nmda neurotransmission plays an important role in learning and memory. nmda receptor-enhancing agent improved the cognitive function of patients with early-phase alzheimer's disease. this study is a randomized, double-blind, placebo-controlled drug trial. all subjects will be allocated randomly to 2 groups: (1) daoib group; (2) placebo group. the study period is 24 weeks. the investigators hypothesize that daoib may yield better efficacy than placebo for cognitive function in patients with mild cognitive impairment.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of mild cognitive impairment * mmse between 17-26 * cdr 0.5 exclusion criteria: * hachinski ischemic score \> 4 * substance abuse/dependence * parkinson disease, epilepsy, dementia with psychotic features * major psychiatric disorders * major physical illnesses * severe visual or hearing impairment
propolis in primary herpetic gingivostomatitis

Conditions: Herpetic Gingivostomatitis

Summary: the purpose of the present study is to investigate the efficacy of 5% propolis gel in the treatment of primary herpetic gingivostomatitis in children and its effect on salivary ifn-γ levels.


Eligibility criteria:
inclusion criteria: * clinical manifestations suggestive of phgs * positive culture for hsv-1 exclusion criteria: * negative culture for hsv-1 * allergic to honey or its products * patients diagnosed with any systemic diseases, immunosuppressed or immunocompromised patients
carbohydrates and gut hormones after gastric bypass surgery

Conditions: Overweight

Summary: to investigate the secretion of gut hormones, in particular glucagon-like peptide 1 (glp-1), after ingestion of glucose and fructose as separate monosaccharides or combined in the disaccharides sucrose and isomaltulose and the effect of acarbose in gastric bypass operated subjects and bmi-matched controls.

disaccharides such as sucrose or isomaltulose (also called palatinose) require digestion into monosaccharides (both are digested to glucose and fructose) by enzymes located in the brush border of the small intestine to be absorbed. the study will investigate the influence of carbohydrate digestion on gut hormone secretion.

Eligibility criteria:
gastric bypass operated patients: inclusion criteria: * uncomplicated gastric bypass surgery performed minimum 12 months prior to study exclusion criteria: * type 1 or 2 diabetes mellitus prior to or after gastric bypass surgery * pregnancy or breastfeeding * haemoglobin levels below 6,5 mm healthy control subjects: exclusion criteria: * bariatric surgery or complicated upper abdominal surgery * pregnancy or breastfeeding * haemoglobin levels below 6,5 mm * co-morbidities or medicine significantly affecting glucose metabolism or appetite regulation

Keywords: glucagon-like peptide 1 carbohydrates gastric bypass bariatric surgery overweight
persistent covid-19 symptoms in minia

Conditions: COVID - 19

Summary: objective this study aims to identify the nature and prevalence of persistent symptoms in patients discharged from minya university hospitals in egypt after recovery from covid-19, the severity of these symptoms, and the possible risk factors associated with them.

this is a cross-sectional observational retrospective study. the study population included patients, both hospitalized and non-hospitalized, who were diagnosed with covid-19. demographic information, symptom severity, present comorbidities, and persistent covid-19 symptoms were collected. spss software was used for the statistical analysis, and p-values less than 0.05 were considered significant.

Eligibility criteria:
inclusion criteria: - inclusion criteria patients were included in this study if they tested positive for covid-19 at the time of their illness (positive covid-19 polymerase chain reaction \[pcr\] test) or if laboratory, clinical, and radiological criteria suggested the infection with covid-19, and the severity of their symptoms ranged from asymptomatic to severe. both hospitalized and non-hospitalized patients were included. exclusion criteria: exclusion criteria patients excluded were frail or at the end of their life or had severe cognitive dysfunction, as well as patients \<18 years of age. -

Keywords: covid19 risk factors self-medication
limbal astigmatic keratotomy to correct high degrees of astigmatism after phacoemulsification

Conditions: Astigmatism

Summary: compare manually performed astigmatic keratotomy to femtosecond laser astigmatic keratotomy to manage corneal astigmatism more than three diopters after phacoemulsification.

create circumferential corneal incisions, following the limbal curvature, at 1-1.5 mm anterior to the limbus, manually and by using femtosecond laser to correct corneal astigmatism more than three diopters after phacoemulsification.

Eligibility criteria:
inclusion criteria: * possibility to have informed consent and attendance of all study visits. * patients who have undergone conventional phacoemulsification at least one month ago. * clear cornea. * astigmatism more than 0.5 diopters. exclusion criteria: * corneal opacity. * history of corneal surgery. * thin cornea. * astigmatism equal to or less than 0.5 diopters.
pilot study of vitamin d supplementation in heart failure

Conditions: Heart Failure

Summary: the purpose of this study is to determine if the methods are feasible for a larger clinical trial.the study will examine the relationship between vitamin d status, quality of life, pain and walking distance of individuals living with heart failure.

this study is being conducted as a pilot project to determine the feasibility of the methods to inform the conduct of a future larger study. this double-blind randomized controlled trial will examine the relationship between vitamin d status, quality of life (qol), pain and functional capacity of individuals living with heart failure (hf) pre and post vitamin d supplementation. the study outcome measures include: the rate of recruitment, retention and compliance with the study procedures. quality of life will be measured by the eq-5d™ questionnaire; the brief pain inventory (bpi) will be used to evaluate subject pain. the 6-minute walk test (6mwt) will evaluate functional capacity. serum 25-hydroxyvitamin d (25ohd) levels will quantify the adequacy of vitamin d dosing to achieve target 25ohd levels. a convenience sample of 40 subjects (20 per treatment group) will be prospectively recruited from the royal columbian hospital (rch) heart function (hfx) clinic. subjects will be randomized to receive either vitamin d3 (cholecalciferol) or a matching placebo at a dose of 20,000 iu daily for 30 days followed by 20,000 iu once weekly for 8 weeks. subjects will have their 25ohd levels measured, self-administer the eq-5d™ and bpi questionnaires and perform the 6mwt at the study entry and again at the completion of the study (12 weeks after entry). descriptive statistics (mean, standard deviation and proportion as appropriate) will be used to describe the data. the feasibility of all study procedures will be reported by percentage and compared to the standard set by the team of 80%.

Eligibility criteria:
inclusion criteria: * 65 years of age or older * new york heart association functional class ii or iii symptoms * ability to communicate in english or through a translator * competent to sign the informed consent exclusion criteria: * co-morbidity that would negatively impact quality of life (e.g. severe arthritis, or fibromyalgia) * co-morbidity that would negatively impact vitamin d metabolism (glomerular filtration rate-15-29%, significant liver dysfunction * on a pharmaceutical agent that could lower vitamin d levels (e.g. glucocorticoids, anticonvulsants) * taking \>600 iu vitamin d (cholecalciferol or ergocalciferol) daily * moderate or severe cognitive impairment * contraindication to vitamin d supplementation: history of hypercalcemia or conditions that increase the risk of hypercalcemia (sarcoidosis, tuberculosis or lymphoma) * wheelchair bound (ambulation is a component of the qol questionnaire

Keywords: heart failure vitamin d pain pilot study rct
a study of the effects of fish protein intake on glucose regulation in overweight and obese adults.

Conditions: Obesity; Overweight

Summary: the purpose of this study is to compare the possible health benefits of intake of proteins from salmon, herring, cod and milk on glucose tolerance in overweight and obese adults. overweight and obese subjects often have reduced glucose tolerance, and previous findings from a study on cod proteins suggested that glucose tolerance was improved.

participants receive 2.5g protein per day for 8 weeks as tablets.

Eligibility criteria:
inclusion criteria: * bmi above 27 kg/m2 * healthy exclusion criteria: * fasting blood glucose above 7 mm * medication that affects blood glucose, lipids and inflammatory status * pregnancy or breastfeeding * allergies to fish or milk * intentional weight loss and large fluctuation in body weight * a high consumption of fish * an extreme diet * use of fish oil, n-3 or multivitamin supplements
ischemic conditioning as an intervention to improve motor function in chronic stroke

Conditions: Stroke

Summary: the investigators will test whether an intervention called ischemic conditioning can improve paretic leg motor function in chronic stroke subjects.

this study will study ischemic conditioning (ic) as an intervention to improve motor function post-stroke. ic is a well studied, well tolerated intervention which has been shown to improve regional blood flow, motor neuron excitability and muscle function in multiple patient groups and in young, healthy subjects. because ic targets three physiological systems which are all affected by stroke, the investigators hypothesize that repeated bouts of ic will result in improved motor function of the paretic leg.

Eligibility criteria:
inclusion criteria: 1. be between the ages of 18-85 2. able to give informed consent 3. be ≥ 6 months post diagnosis of unilateral cortical stroke and 4. have residual leg paresis. exclusion criteria: 1. chronic low back or hip pain 2. substance abuse 3. head trauma in last 6 months 4. neurodegenerative disorder 5. any uncontrolled medical condition 6. any condition where knee extension contractions are contraindicated 7. people who are unable to follow multi step commands. 8. people who cannot walk ≥ 10 ft without physical assistance. 9. history of major psychiatric disorder 10. participant has had a myocardial infarction in the last year 11. participant has uncontrolled hypertension 12. participant is unable to contract knee muscles
can minimally invasive decompression surgery restore sagittal balance in a patient population with sagittal imbalance and lumbar spinal stenosis

Conditions: Lumbar Spinal Stenosis

Summary: from adulthood onwards, the aging process manifests itself in the spine through loss of disc height and kyphotic deformity. as the general population ages, the prevalence of lumbar degenerative diseases and sagittal imbalance increases. sagittal balance is a physiological alignment resulting from the effective muscular and ligamentary forces that place patients' heads harmoniously in line with their pelvis. roussouly first classified this alignment by differentiating four types of balance in an asymptomatic population. he established a link between the varieties of sagittal balance of the spine, the sacral slope and the position of the pelvis in space. he went on to explain sagittal imbalance in the aging population suffering from degenerative diseases. one of the most common lumbar degenerative diseases is lumbar spinal canal stenosis. stenosis of the lumbar spinal canal is frequently associated with sagittal imbalance of the spine. lumbar canal stenosis causes lumbar pain, leg pain, neurogenic intermittent claudication and bladder and rectal disorders. the severity of clinical symptoms increases linearly with progressive sagittal imbalance \[8\]. we represent the sagittal imbalance of the spine by a positive sagittal vertical axis (sva) presented by patients to reduce the pressure exerted by the yellow ligament, which is hypertrophied in degenerative disease . many have shown that this forward-flexing posture can be improved by simple decompression, and that this deformity corresponds to an analgesic position and not to a structural deformity. little is known about the factors that influence alignment after lumbar canal decompression and short segment fusion. this study therefore aims to elucidate some of the clinical and radiological factors likely to affect postoperative sagittal balance in patients undergoing simple minimally invasive decompression surgery and short segment fusion (1 or 2 levels).


Eligibility criteria:
inclusion criteria: * patient age ≥ 18 years * french-speaking patients * patients undergoing minimally invasive lumbar decompression with or without one- or two-level arthrodesis * patients with preoperative sagittal imbalance measured on eos images (sagittal vertebral axis \> 50 mm) exclusion criteria: * patients under guardianship or curatorship * patient deprived of liberty * patient under court protection * patient objecting to the use of his or her data for this study * revision surgery

Keywords: lumbar stenosis sagittal imbalance minimally invasive decompression surgery
relation of obesity with frequency of meals (mst 0557)

Conditions: Obesity; Insulin Resistance; Fatty Liver

Summary: the purpose of this study is to test the relationship between frequency of meals and hepatic fat content and insulin sensitivity. we, the researchers at rockefeller university, hypothesize that low plasma insulin levels (as achieved by periods of fasting) will prevent insulin resistance and reduce hepatic lipid content. in contrast, frequent, carbohydrate-rich meals will predispose to hepatic steatosis (non-alcoholic) and insulin resistance. this is a 6 week inpatient study.

the hypothesis will be tested by studying two groups of normal subjects who will receive a defined weight maintenance diet: one group will be given meals twice a day and other group will be given eight meals (snacks) per day. at the beginning of the study period and after 4 weeks following the specified frequency of meals, the study subjects will have their whole body insulin sensitivity and hepatic fat content measured by the euglycemic-hyperinsulinemic clamp and mri of the liver, respectively.

Eligibility criteria:
inclusion criteria: 1. healthy individuals 2. age between 18-45 years 3. body mass index (bmi) between 18.5 - 24.9 exclusion criteria: 1. diabetes mellitus 2. chronic drug treatment for any medical condition like hypertension or hyperlipidemia, hyperthyroidism or taking weight control medications. 3. inability to give informed consent. 4. inability to give contact information including permanent residence or provide evidence of stable living environment for the study period. 5. active weight reduction of more than 7 pounds in the last 3 months. 6. history of bleeding or blood clotting disorders. 7. pregnancy or breast-feeding in the women. 8. history of anaphylaxis or anaphylactoid-like reaction as a result of food allergies. 9. hiv or hepatitis b and c positive subjects. 10. subjects with hemoglobin \< 8.5 gm/dl. 11. abnormal liver function test (alt, ast, alkaline phosphate, ldh, ggt or total bilirubin). 12. serum creatinine or bun greater than the upper limit of the normal, serum albumin less than 3.5g/dl, or proteinuria 1+ or greater. 13. history of alcohol intake of more than 40 g/day. 14. contraindications to magnetic resonance imaging (mri) including pacemakers, surgical clips, metallic implants, neuromuscular- skeletal stimulators and internal orthopedic screws or rods.

Keywords: non-alcoholic hepatic steatosis
the step 4life trial

Conditions: Alzheimer Disease, At Risk; Alzheimer Disease, Protection Against; Dementia

Summary: the objective of this study is to test the feasibility of using behavioral economic interventions (gamification with social incentives) targeting daily step counts to prevent or delay the development of alzheimer's disease and related dementias (adrd).

increased physical activity by walking further or more vigorously may prevent or delay the development of alzheimer's disease and related dementias (adrd) but reaching higher levels of activity and maintaining it as a long-term habit is difficult to do. this project will use concepts from behavioral science to create a game older adults can play in order to increase their levels of activity while having fun doing it. the game is played with a support partner who is a spouse, family member, or close friend who provides feedback and encouragement to help the game-player reach activity goals and maintain them as habits over time. participants in the game will use their own smartphone and a wristwatch that tracks activity (such as a fitbit, provided by this study) to set goals, get feedback, and play the game for 12 weeks. participants will be asked to continue wearing the wristwatch for another 6 weeks to track activity after the game is over. to determine the effectiveness of this game, investigators will randomly assign 50 people to the game and 50 people to only get the wristwatch but no game component. all participants in this study will be recruited from an online registry of adults age 55-75 who have not been diagnosed with alzheimer's (genematch) which offers genetic testing on risk for adrd to all participants. investigators will recruit participants who have elevated genetic risk as well as those without specific genetic risks for the study to see if either group responds differently to the game.

Eligibility criteria:
inclusion criteria: * own a smartphone * be enrolled in genematch * know their genetic testing results (apoe4) * able to provide informed consent exclusion criteria: * inability to provide informed consent * does not have daily access to a smartphone compatible with the wearable device and not willing to use a device that we can provide them * already enrolled in another physical activity study * unable to ambulate independently * any other medical conditions that would prohibit participation in physical activity program

Keywords: alzheimers disease gamification physical activity behavioral science
corona in the saarland

Conditions: Covid19

Summary: the corsaar study is an observational, prospective study to investigate the natural biology of covid-19

patients with all forms of covid-19 are included and followed up. medical history, measurements and biomarkers are registered and collected at baseline, dung hospitalization and after discharge. in addition, patients with long-covid-19 are recruited.

Eligibility criteria:
inclusion criteria: all form of covid-19 including long-covid-19 exclusion criteria: -