Kornimate/medical-research-clean huggingface dataset:
exercise programs on gait in children jia

Conditions: Juvenile Idiopathic Arthritis; Gait, Frontal

Summary: juvenile idiopathic arthritis (jia) is one of the common chronic diseases in childhood. problems such as weakness or pain may occur in jia, especially in the joints and the muscles around the trunk. these conditions may lead to abnormal displacement of the center of gravity, deterioration of biomechanics, and muscle imbalance in children with jia. all these situations can lead to postural imbalance and asymmetrical loading pattern, which we often encounter in children with jia. current studies describing various exercise methods effective on postural alignment. however, no study was found in the literature that searching the effects of these exercise methods on gait parameters in children jia.

juvenile idiopathic arthritis (jia) is one of the common chronic diseases in childhood. problems such as weakness or pain may occur in jia, especially in the joints and the muscles around the trunk. these conditions may lead to abnormal displacement of the center of gravity, deterioration of biomechanics, and muscle imbalance in children with jia. these conditions may lead to abnormal displacement of the center of gravity, deterioration of biomechanics, and muscle imbalance in children with jia. all these situations can lead to postural imbalance and asymmetrical loading pattern, which we often encounter in children with jia. current studies describing various exercise methods effective on postural alignment. however, no study was found in the literature that searching the effects of these exercise methods on gait parameters in children jia. therefore, this study aimed to investigate the effects of two different exercise programs (core based exercise program against neuromuscular training) on gait parameters in children jia. in this study, the participants will be evaluated and then they will be divided into two groups randomly. the first group will be administered as a core based exercise program group and the second one will be undergone as a neuromuscular training group. after the interventions, they will be re-evaluted by the physiotherapist and the outcomes will be recorded.

Eligibility criteria:
inclusion criteria: * having a diagnosis of oligoarticular jia * being between the age of 8 and 16 * having included knee joint. exclusion criteria: * having an additional neurological or orthopedic diagnosis other than jia affecting treatment results, * having had any surgery on the spine or the extremity joints * being at a level that will not understand the questions asked.

Keywords: juvenile idiopathic arthritis gait exercise physiotherapy
trastuzumab based therapy in her2 positive agc

Conditions: Gastric Adenocarcinoma

Summary: trastuzumab plus chemotherapy is an effective therapy in her2 positive advanced gastric cancer (agc). however, the efficacy of routine trastuzumab therapy and its association with clinicopathologic factors remain unclear. the object of the study is to determine whether the addition of trastuzumab to first-line chemotherapy improves efficacy compared with chemotherapy alone in her2 positive agc.

a total of 98 patients with her2 positive agc were enrolled in this prospective observational study. all patients were treated with trastuzumab plus chemotherapy as the first line therapy. efficacy and safety of trastuzumab were analyzed, clinical and pathological data were collected to evaluate the potential prognostic factors on progressive free survival.

Eligibility criteria:
inclusion criteria: 1. pathology and medical imageology proven advanced gastric adenocarcinoma, inoperable; 2. received trastuzumab plus chemotherapy as the first-line palliative chemotherapy; 3. with measurable lesion with a diameter 20 mm using conventional computed tomography (ct) or magnetic resonance imaging (mri) scans or 10 mm using spiral ct scans; 4. eastern cooperative oncology group performance status (ecog ps ) of 0-2; 5. left ventricular ejection fraction(lvef) more than 50 percents; 6. sufficient bone marrow, liver and renal function. exclusion criteria: 1. received previous systemic therapy for advanced disease (except adjuvant/neoadjuvant chemotherapy completed at least 6 months before enrollment); 2. trastuzumab based adjuvant/neoadjuvant therapy; 3. treatment with any other anticancer therapy (lapatinib, immunotherapy, etc); 4. patients with heart failure, coronary artery disease or myocardial infarction within the previous 6 months. 5. trastuzumab based first line therapy started beyond 4 weeks from the first diagnoses of agc.

Keywords: gastric cancer her2 trastuzumab prognosis
alicia (acalabrutinib in cll therapy)

Conditions: Chronic Lymphocytic Leukemia

Summary: this is a multicenter non-interventional observational study conducted with a single hand arm to collect real-world data. in this study, commercially available acalabrutinib will be used as prescribed treatment for cll as per the treating physician's best clinical judgement. no additional procedures besides those already used in the routine clinical practice will be applied to the patients. treatment assignment will be done according to the current practice. a multi-center collaborative effort in 15 centers selected from regions within russia will help capture more patients into the database, rather than limiting the data to a single institution. this will be critical for: * increasing database sample size * reducing bias (single institution bias) * increasing result's generalizability to the whole russian population being an observational study, only data available from routine clinical practice and standard of care (soc), in line with national and international laws and regulations, will be recorded. patients will be treated according to prescribing information, with visit frequency and assessments performed according to routine medical practice and soc. only data corresponding to these visits and assessments will be collected as part of the study. data for the study will be transcribed and entered into an electronic case report form (ecrf) from the patient's medical records. the site investigator will be responsible for ensuring that all required data is collected and entered into the ecrf with the involvement of clinical research organization


Eligibility criteria:
inclusion criteria: * age ≥18 years * confirmed diagnosis of cll * patient started treatment with monotherapy acalabrutinib (prescribed by physician decision no more than 4 weeks ago before screening) * capability of providing written informed consent form exclusion criteria: * patients not corresponded to inclusion criteria * pregnancy * lactation * patients included in open-label trials * previous bruton tyrosine kinase inhibitors (btki) treatment

Keywords: chronic lymphocytic leukemia
psychological impact of haploidentical allogeneic hematopoietic stem cell transplantation on donors

Conditions: Haplo-identical Transplantation; Transplantation

Summary: allogeneic hematopoietic stem cell transplantation (allo-hsc) is currently one of the only curative treatments for haematological malignancies with a poor prognosis, the realization of which presupposes the identification and availability of a compatible donor. in recent years, haploidentical transplants have been developed, a reliable alternative for patients who do not have 100% compatible donors. the development of haplo-identical transplants leads to an exponential increase in the use of intra-family donation. intrafamilial donation of hematopoietic stem cells (hsc) has the advantages of lower financial cost and faster availability of the graft, thus avoiding the risk of relapse before the procedure. nevertheless, intrafamilial donation raises clinical and ethical questions. indeed, the psychological impact of intra-family donation on the donor cannot be overlooked. thus, in the context of the development of haplo-identical transplants, measuring the impact of donation on donors (ascendants and descendants) will make it possible to assess the relevance of taking psychosocial aspects into consideration in the choice of donors, to assess the psychological impact of haplo-identical donation and to offer psychological support adapted to donors.

this is a prospective, exploratory and bicentric study with a quantitative and qualitative approach, with the aim of exploring the psychosocial aspects of the experience of haplo-identical transplantation in adult hsc donors for transplantation. haplo-identical for their children or for their parents. for this, the evolution of the anxiety and depression) of the donors will be evaluated on d0, d90, d180 and d360 post donation, thanks to state-trait anxiety inventory questionnaire, center for epidemiologic studies depression scale and by the 12-item short form health survey;

Eligibility criteria:
inclusion criteria: * identical haplo csh donors ascending (parents) or descending (children) * major identical haplo hsc donors * haplo-identical hsc donors living in mainland france and cared for in the centers participating in the study * haplo-identical hsc donors benefiting from social security system. * haplo-identical hsc donors who have signed the consent form * - ability to read and write in french exclusion criteria: - insufficient understanding of the french language

Keywords: hsc transplantation anxiety depression donors hematology familly psychic state
body image in youth with hiv

Conditions: Human Immunodeficiency Virus; HIV

Summary: this is an observational study that seeks to gather information about perceptions of body image through the use of a one-time questionnaire completed by participants at the time of study enrollment. effective management of human acquired immune deficiency syndrome (aids) caused by the human immunodeficiency virus (hiv) has become possible through the use of highly active antiretroviral treatment (haart). as a result of more successful treatment options, hiv/aids has transitioned from a terminal illness to one which is treated as a chronic condition. one particular group that has been impacted tremendously by hiv in the united states is the adolescent population. as youth are living longer with hiv/aids, clinicians and researchers are beginning to examine ways in which the disease can affect one's physical health, mental health, and other psychosocial factors. research emerging involving adults with hiv/aids has suggested that increased attention to and negative views of one's body image may be found at a higher rate in this group. to our knowledge, very few studies have examined this relationship in adolescents with hiv.

the purpose of this exploratory study is to characterize body image perceptions among youth with perinatally and behaviorally acquired hiv. in a cross-sectional design, adolescents will be asked to complete an acasi questionnaire that will assess body image, medication adherence, depressive symptoms, medical, and other sociodemographic variables which may relate to adolescents with hiv. information regarding the adolescents' medical history, medications, and physical functioning also will be abstracted from his or her medical record. guided by the intervention mapping (im) approach, findings from this study will inform future intervention studies designed to enhance hiv disease management among adolescents. primary objective: to characterize body image perceptions among youth with hiv.

Eligibility criteria:
inclusion criteria: * diagnosis of hiv infection as documented in adolescent's medical record * adolescent is aware of his/her hiv diagnosis * the adolescent/caregiver's primary language in english * adolescent is ≥ 16 and \< 24 years old * adolescent is willing and able to provide consent per institutional guidelines exclusion criteria: * adolescent has documented diagnosis of mental retardation or a significant motor or sensory impairment that would preclude participation in the study survey. * adolescent has known acute psychiatric illness, including suicidal ideation, homicidal ideation or active psychosis. * adolescent is a pregnant female.

Keywords: adolescents body image
anterior stromal changes after prk by using intraoperative mitomicin c

Conditions: Refractive Disorders

Summary: to evaluate the confocal microscopy changes in keratocyte density at the anterior stromal after photorefractive keratectomy (prk) surgery, using intraoperative mitomycin c(mitolem, lemery, s.a. de c.v. mexico d.f. reg. 136m92 ssa).

10 eyes of 10 patients underwent prk,using intraoperative mitomycin c (mitolem, lemery, s.a. de c.v. mexico d.f. reg. 136m92 ssa), and 10 eyes for the same patients underwent prk without intraoperative mitomycin c. a central scan of the total corneal thickness was taken with the confocal microscope (confoscan 4, fortune technologies, italy) after surgery, and 1 week, 1 month, 3 months, and 6 months after surgery. corneal epithelial thickness and the anterior stroma morphology were analyzed by using the navis software v. 3.5.0 (nidek, multi-instrument diagnostic system, japan).

Eligibility criteria:
inclusion criteria: * patients ask for prk surgery * patients with stable refraction in the last year * patients without systemic and ocular disease * patients with 500 microns in pachymetry normal topography exclusion criteria: * patients cannot attend their appointments * residual, recurrent or active ocular disease * previous ocular surgery except prk * autoimmune or connective tissue disease * pregnancy

Keywords: mitomycin c corneal epithelium photorefractive keratectomy (prk) confocal microscope
low dose versus usual dose dexamethasone for symptom control in children undergoing cranial or craniospinal radiation

Conditions: Vomiting; Headache

Summary: the purpose of this study is to evaluate the effectiveness of low dose dexamethasone versus high dose dexamethasone in the treatment of radiation induced vomiting.

dexamethasone is an effective medication to ameliorate radiation induced headache and vomiting. in our toronto experience dexamethasone in low doses (1 mg/m2/day) is sufficient in treating these symptoms. however this experience is not shared from many neuro-oncology centers of excellence that more commonly use 5 mg/m2/day according to the results of the trans-canadian survey. a prospective multicenter trial evaluating the effectiveness of dexamethasone in different dose regimens in symptomatic children while undergoing cns radiation will elucidate the appropriate dose.

Eligibility criteria:
inclusion criteria for enrolment: * children between 2-18 years of age. * children who underwent resection of a brain tumour with ≤ 1.5 cm2 residual tumour after surgical resection. * children regardless of extent of leptomeningeal or spinal metastasis (m1-3) are eligible. * children who undergo focal or whole brain (± spinal) radiation as part of their brain tumour treatment. * children treated at one of the 16 tertiary care centers in canada (cpbtc). * patients on any anticonvulsive treatment are eligible. * patients on concomitant chemotherapy while undergoing radiation are eligible. * patients must be ≥ 24 hours steroid-free prior to starting radiation. * parents/legal guardians have to have signed and dated an informed consent to allow study enrolment of their child. (as per institutional guidelines, patients over a certain age may have signed their own informed consent form.) * patients \> 8 years of age should assent to study participation. * patients less than 10 years of age should have a lansky score of \>/= 50. * patients 10 years of age or older should have a karnofsky score of \>/= 50. if ecog performance scale is used, patient should have a score of 0, 1 or 2. exclusion criteria for enrolment: * children with residual brain tumour lesion \> 1.5 cm2 after surgical resection. * children on steroids (dexamethasone) that will not be stopped ≥ 24 hours prior to start of radiation therapy. inclusion criteria for randomization to a dexamethasone treatment group: * patients must have been enrolled on the dexamethasone study prior to the start of radiation therapy. * children who develop either symptoms of vomiting (defined as either retching or vomiting ≥ once per day) or headache (≥ 2 points increase in severity of the most intense headache/day) while undergoing irradiation. * patients who are currently undergoing focal or whole brain (± spinal) radiation. exclusion criteria for randomization to a dexamethasone treatment group: * patients who were not enrolled on dexamethasone study prior to start of radiation therapy.

Keywords: pediatrics vomiting headache radiation therapy
randomized study of beta interferon and thalidomide in patients with adrenoleukodystrophy

Conditions: Adrenoleukodystrophy

Summary: objectives: i. evaluate the efficacy of interferon beta and thalidomide in male patients with adrenoleukodystrophy who show evidence of brain inflammatory response and are receiving concurrent glyceryl trierucate and glyceryl trioleate (lorenzo's oil). ii. evaluate the progress of the disease and possible side effects of the medication in these patients.

protocol outline: this is randomized, double blind, placebo controlled study. patients are randomized to receive beta interferon and thalidomide placebo (arm i), thalidomide and beta interferon placebo (arm ii), or placebo for both beta interferon and thalidomide (arm iii). patients receive interferon beta by subcutaneous injection and thalidomide orally. all patients are maintained on glyceryl trierucate and glyceryl trioleate (lorenzo's oil) therapy. patients are followed at 3, 6, and 12 months and then may be followed every 6 months thereafter.

Eligibility criteria:
protocol entry criteria: --disease characteristics-- adrenoleukodystrophy (ald) diagnosis based on history and examination, mri, and biochemical assay clinical evidence of rapidly progressive phase of cerebral ald must include 2 or more of the following during the preceding year: significant and progressive impairment of school performance significant loss of cognitive function leading to an iq of 75 or less progressive impairment of the ability to understand spoken words progressive impairment of vision progressive deterioration of handwriting progressive difficulty in walking progressive impairment in speech articulation, and vocabulary progressive weakness of one or more limbs must have mri abnormalities characteristic of cerebral ald, especially evidence of the breakdown of the blood-brain barrier using gadolinium contrast medium and magnetization transfer technique evidence of brain white matter inflammatory response must not meet criteria for bone marrow transplantation not in an apparent vegetative state --prior/concurrent therapy-- concurrent glyceryl trierucate and glyceryl trioleate (lorenzo's oil) therapy required --patient characteristics-- effective contraception required of all patients

Keywords: adrenoleukodystrophy inborn errors of metabolism rare disease sphingolipidoses
the effect of web-based exercises on postural deformities

Conditions: Telerehabilitation; Posture; Lordosis; Kyphosis; Home Based Rehabilitation

Summary: this study aims to investigate the effect of telerehabilitation with web-based exercises on postural deformities in individuals with postural problems. this randomized controlled study is planned to include 40 individuals. the individuals will be university students between the ages of 18-25. the students will be divided into two groups: home exercise program and telerehabilitation group. exercises will be applied to both groups 3 times a week for 6 weeks.

objective: recent studies have shown that the use of telerehabilitation in different areas can result in significant clinical gains. the effect of telerehabilitation on head forward posture, thoracic hyperkyphosis and lumbar hyperlordosis is not yet fully understood. therefore, this study aims to investigate the effect of telerehabilitation with web-based exercises on postural deformities in individuals with postural problems. method: this randomized controlled study is planned to include 40 individuals. the individuals will be university students between the ages of 18-25. the students will be divided into two groups: home program and telerehabilitation group. exercises will be applied to both groups 3 times a week for 6 weeks. individuals with postural problems will be evaluated for craniovertebral, kyphosis and lordosis angles, shortness of hamstring and pectoral muscles and trunk endurance. craniovertebral, kyphosis and lordosis angles will be evaluated with the "clinometer + buble" application, muscle shortness will be evaluated with muscle shortness tests, and trunk endurance will be evaluated with trunk endurance tests.

Eligibility criteria:
inclusion criteria: * volunteering for research, * be a young adult between the ages of 18 and 25, * to be a student of sbu gülhane faculty of ptr, * body mass index less than 30 kg/m2, * cranioverterbral angle less than 52 degrees, exclusion criteria: * - neck, back or lower back pain, * being a regular exerciser or professional/amateur athlete * having a three-dimensional deformity such as scoliosis, * having a previous operation, neurological, orthopedic or congenital problem in the spine, * visual and hearing loss that prevents them from performing the assessments and exercises, * physiotherapy within the last 6 months,

Keywords: telerehabilitation posture lordosis kyphosis exercise
the use of cervical length to reduce hospital stay in women admitted because of preterm labor.

Conditions: Labor, Premature; Cervical Length

Summary: the objective of this study was to investigate the effect of the use of sonographic cervical length (cl) on the hospital stay in women admitted because of preterm labor.

eligible women who agreed to participate in the study were randomized by means of a central randomization office into two groups: control group: cervical length was measured but the result was blinded to the physician in charge and women was managed according to the standard protocol. study group: cervical length was measured and the result was reported to the physician in charge. if cervical length was of 25 mm or more, discharge in 12-24 h was recommended. if cervical length was less than 25 mm, decision on discharge was made following clinical criteria.

Eligibility criteria:
inclusion criteria: * admitted because of preterm labor * not delivered after 24-48 h of admission * single pregnancy * intact membranes * gestational age between 24.0 and less tahn 36.0 weeks * bishop score \< 6 exclusion criteria: * fetal death or malformation * signs of chorioamnionitis * non-reassuring fetal test

Keywords: preterm labor cervical ultrasonography hospital stay
the use of butyrate therapy in pediatric ulcerative colitis

Conditions: Ulcerative Colitis

Summary: butyrate is an important metabolite produced by the gut microbiome and has been shown as a helpful therapy in ulcerative colitis. this is a feasibility study to determine the efficacy of butryate enemas in pediatric ulcerative colitis.

butyrate enemas will be administered for 12 weeks to children ages 7 to 21 with mild to moderate ulcerative colitis to determine if butyrate therapy can help improve the clinical disease in those children. standard management of the disease will be performed during these 12 weeks including routine laboratory studies and endoscopy.

Eligibility criteria:
inclusion criteria: * 7-21 years, mild to moderate ulcerative colitis exclusion criteria: * uc therapy within 4 weeks of study medication initiation * infectious colitis, -pregnancy

Keywords: ulcerative colitis