Kornimate/medical-research-clean huggingface dataset:
empowerment program for cancer survivors

Conditions: Cancer Survivors

Summary: this study aims to decrease cancer survivors' intrusive ruminative thoughts and cancer-related fatigue and increase their purposive ruminative thoughts and psychological resilience. in this context, an online (zoom) 10-session empowerment program based on the literature will be implemented for cancer survivors.

from the time they were diagnosed with cancer, individuals struggle with ruminative thoughts about why they have this disease, whether they will get better during the treatment process, whether the disease will recur in the future, and cognitive, physical, and emotional fatigue, the cause of which cannot be fully explained. all these processes continue to negatively affect the lives of cancer survivors during the remission period. studies show that when cancer survivors manage this stressful process well and learn effective coping methods, they can come out of it by developing their psychological resilience. therefore, this study aimed to determine the effect of an empowerment program to be applied to cancer survivors' ruminative thoughts, cancer-related fatigue, and psychological resilience. the hypotheses of this research are: h 1-1: there is a difference between ruminative thinking scores at the end of the empowerment program applied to individuals with cancer in remission and in the follow-up measurement compared to the pre-program and control groups. h 1-2: there is a difference between cancer-related fatigue scores at the end of the empowerment program applied to individuals with cancer in remission and in the follow-up measurement compared to the pre-program and control groups. h 1-3: there is a difference between psychological resilience scores at the end of the empowerment program applied to individuals with cancer in remission and in the follow-up measurement compared to the pre-program and control groups.

Eligibility criteria:
inclusion criteria: * volunteering to participate in the research, * being between the ages of 18-65, * to have knowledge of reading and writing in turkish, * being in remission * to have technical equipment (camera, microphone, computer) and usage knowledge to participate in the online group session exclusion criteria: - to have received psychological support in the last year

Keywords: patient nursing cancer psychological resilience rumination fatigue
assessing the impact of live music in the intensive care unit (icu) to improve care for critically ill patients

Conditions: Anxiety; Pain; Critical Illness; Relaxation

Summary: noise in the icu can worsen patient outcomes through factors such as increased cardiovascular stress, alteration in sleep, and increased discomfort or pain the purpose of this study is to determine the benefit of therapeutic music in the icu on patients, their families, and icu staff.

noise in the icu can worsen patient outcomes through factors such as increased cardiovascular stress, alteration in sleep, and increased discomfort or pain. the purpose of this study is to determine the benefit of therapeutic music in the icu on patients, their families, and icu staff. the results of this study will inform clinicians on best practices for redesigning, implementing and evaluating a patient and family focused therapeutic music program in the icu.

Eligibility criteria:
patient inclusion criteria: * current hospitalization in adult icu at vanderbilt university medical center patient exclusion criteria: * airborne or special contact isolation * unstable hypotension or bradycardia * pregnancy * current prisoner status * the inability to communicate either verbally or in writing in english to complete the therapeutic music evaluations * refusal to participate family member inclusion criteria * family member of icu patient family member exclusion criteria * the inability to communicate either verbally or in writing english to complete the therapeutic music evaluations * refusal to participate icu clinical staff inclusion criteria * icu clinical staff who are in the patient's room during the music session icu clinical staff exclusion criteria * refusal to participate
pelvic floor reconstruction using biological mesh with negative pressure wound therapy following elape

Conditions: Perineal Wound Complications After ELAPE

Summary: perineal wound healing is a significant challenge after extralevator abdominoperineal excision (elape) due to a high rate of wound breakdown. and it was proved that neoadjuvant radiotherapy significantly increases perineal wound problems after abdominoperineal resection for rectal cancer. negative pressure therapy has proven benefits in open wounds, and recently a negative pressure system has been developed for use on closed wounds at high risk of breakdown. a systematic review suggested a significant decrease in perineal wound complications when using incisional negative pressure wound therapy was demonstrated, with surgical site infection rates as low as 9% (vs 41% in control groups). the review suggested that incisional negative pressure wound therapy decreases perineal wound complications after abdominoperineal resection. prospective study also suggested that after elape the application of a negative pressure system to the perineal wound closed with biologic mesh may reduce perineal wound complications. the aim of the present study was to determine whether negative pressure therapy combined with biological mesh compared with biological mesh alone after elape could improve wound healing.


Eligibility criteria:
inclusion criteria: 1. rectal cancer within 4 cm of the anal verge 2. t3 or t4, as determined by pre-operative mri examination; patient did receive neoadjuvant chemoradiotherapy 3. absence of distant metastases 4. absence of intestinal obstruction exclusion criteria: 1. t1-t2, as determined by pre-operative mri before neoadjuvant chemoradiotherapy 2. distant metastases 3. intestinal obstruction 4. pregnancy or lactating 5. contraindications to surgery 6. a mental disorder

Keywords: extralevator abdominoperineal excision perineal wound healing negative pressure wound therapy biological mesh
weekly single fraction hypofractionated adjuvant radiotherapy for early stage breast cancer

Conditions: Breast Cancer; Radiotherapy Side Effect

Summary: the current study is a prospective phase ii study; eligible patients will receive hypofractionated irradiation at a total dose of 28.5gy in 5 once-weekly fractions of 5.7gy in 5 weeks to the whole breast or chest wall with or without peripheral lymphatic irradiation.

testing the feasibility of a hypofractionated adjuvant radiotherapy regimen after breast surgery on a-once-weekly basis for a total dose of 28.5gy in 5 fractions over 5 weeks in kasr el aini hospital.

Eligibility criteria:
inclusion criteria: 1. histologically proven diagnosis of invasive breast adenocarcinoma. 2. prior radical surgery (modified radical mastectomy or breast conservative surgery). 3. no macroscopic evidence of distant metastases at diagnosis. exclusion criteria: 1. prior radiation to the thoracic region. 2. pregnancy. 3. patients with synchronous or prior malignancy. 4. positive surgical margins.

Keywords: breast cancer radiotherapy hypofractionation
a study of the safety and pharmacology of pi3-kinase inhibitor gdc-0941 in combination with either paclitaxel and carboplatin (with or without bevacizumab) or pemetrexed, cisplatin, and bevacizumab in patients with advanced non-small cell lung cancer

Conditions: Non-Squamous Non-Small Cell Lung Cancer

Summary: this is an open-label, multicenter, phase ib dose-escalation study to assess the safety, tolerability, and pharmacokinetics of oral (po) gdc-0941 administered with one of three planned regimens: arm a: paclitaxel and carboplatin in bevacizumab-ineligible nsclc patients, arm b: paclitaxel, carboplatin, and bevacizumab in bevacizumab-eligible nsclc patients and arm c: pemetrexed, cisplatin, and bevacizumab in bevacizumab-eligible, non-squamous nsclc patients.


Eligibility criteria:
inclusion criteria: * histologically or cytologically documented nsclc with advanced disease (stage iiib not eligible for chemoradiotherapy or stage iv or recurrent disease) * adequate organ function as assessed by laboratory tests * evaluable disease or disease measurable per response evaluation criteria in solid tumors (recist) exclusion criteria: * more than one anti-cancer regimen (chemotherapy or radiotherapy) for advanced nsclc prior to initiation of study treatment * any adjuvant or neoadjuvant anti-cancer therapy within a specified timeframe prior to first study treatment * history of grade \>= 3 fasting hyperglycemia or diabetes requiring regular medication * active autoimmune disease, active infection requiring iv antibiotics, or other current uncontrolled illness * history of clinically significant cardiac or pulmonary dysfunction * history of malabsorption syndrome or other condition that would interfere with enteral absorption * clinically significant history of liver disease * any condition requiring full-dose anticoagulants, such as warfarin, heparin, or thrombolytic agents * known brain metastases that are untreated, symptomatic, or require therapy * pregnancy, lactation, or breastfeeding

Keywords: nsclc pi3k avastin
study to assess the safety, pharmacokinetics, and efficacy of baloxavir marboxil in healthy pediatric participants with influenza-like symptoms

Conditions: Influenza

Summary: this study will evaluate the safety, pharmacokinetics, and efficacy of baloxavir marboxil compared with oseltamivir in a single influenza episode in otherwise healthy pediatric participants (i.e., 1 to \<12 years of age) with influenza-like symptoms.


Eligibility criteria:
inclusion criteria: * aged 1 to \< 12 years at randomization (day 1). * written informed consent/assent for study participation obtained from participant's parents or legal guardian, with assent as appropriate by the participant, depending on the patient's level of understanding * participant able to comply with study requirements, depending on the patient's level of understanding * participant with a diagnosis of influenza virus infection confirmed by the presence of all of the following: * fever ≥ 38 degree celsius (tympanic temperature) at screening * at least one respiratory symptom (either cough or nasal congestion) * the time interval between the onset of symptoms and screening is ≤ 48 hours exclusion criteria: * severe symptoms of influenza virus infection requiring inpatient treatment * concurrent infections requiring systemic antiviral therapy at screening * require, in the opinion of the investigator, any of the prohibited medication during the study * previous treatment with peramivir, laninamivir, oseltamivir, zanamivir, or amantadine within 2 weeks prior to screening * immunization with a live/attenuated influenza vaccine in the 2 weeks prior to randomization * concomitant treatment with steroids or other immuno-suppressant therapy * known hiv infection or other immunosuppressive disorder * uncontrolled renal, vascular, neurologic, or metabolic disease (e.g., diabetes, thyroid disorders, adrenal disease), hepatitis, cirrhosis, or pulmonary disease or participants with known chronic renal failure. * active cancer at any site * history of organ transplantation * known allergy to either study drug (i.e., baloxavir marboxil and oseltamivir) or to acetaminophen * females with child-bearing potential * participation in a clinical trial within 4 weeks or five half-lives of exposure to an investigational drug prior to screening, whichever is longer
prehabilitative exercise prior to immobilization

Conditions: Sarcopenia; Skeletal Muscle Atrophy; Disuse Atrophy

Summary: this is a 10-week human study involving 24 younger (20-35 y) and 24 older (65-85 y) healthy individuals. all participants will undergo unilateral immobilization of a knee for 7-10 days, followed by 4 weeks of heavy resistance exercise training (hret). half of the participants (12 younger and 12 older) will also undergo 4 weeks hret prior to the immobilization. prehabilitative exercise may confer protective effects on subsequent immobilization, and the various underlying mechanisms involved


Eligibility criteria:
inclusion criteria: * age: between 20-35 years old or between 65-85 years old. * bmi: between 18.5 and 35 kg/m2. * healthy and well, with normal dietary habits (not vegan). exclusion criteria: * more than one muscle biopsy previously taken from both vastus lateralis muscles. * smoking. * pregnancy. * past or present substance or alcohol abuse. * medical/surgical conditions that are assessed to affect protein synthesis or the participant's involvement in the trial. * knee pain that could affect the completion of the training intervention. * high intake of supplements that increase the risk of bleeding during muscle biopsy (such as fish oil and ginger). * participation in regular strength training within the past year. * regular participation in structured sports. * current use of blood-thinning medication. * previous participation in trials involving oral intake of heavy water. * metal in the body preventing mri scanning. * for the older group, not having gone through menopause, and for the younger group, not having a regular menstrual cycle.
online learning of veterinary anatomy during covid-19 pandemic

Conditions: COVID-19

Summary: this study aims to analyze the online learning of veterinary anatomy during covid-19 pandemic lockdown.

analysis of the online learning of veterinary anatomy during covid-19 pandemic lockdown.

Eligibility criteria:
inclusion criteria: * veterinary medical students who are studying anatomy online during the pandemic lockdown exclusion criteria: -

Keywords: covid-19 anatomy online learning
korean post marketing surveillance for comirnaty injection (bretovameran)

Conditions: COVID-19 Vaccination

Summary: this study is to identify any problems and questions with respect to the safety of comirnaty injection (bretovameran) during the post-marketing period.

all assessments are performed as part of normal clinical practice or standard practice guidelines for the subject population and healthcare provider specialty in the countries where this non-interventional study is being conducted. this study is conducted under normal clinical practice in accordance with regulatory requirements. therefore, the inclusion and exclusion criteria for study subjects are related to indications and contraindications outlined in the local product document. this study will not provide or make recommendations on any vaccine use. the vaccines are all given as part of the standard of care. all enrolled subjects have to meet the general prescription criteria for comirnaty injection (bretovameran) according to the local product document and have to be enrolled at the doctor's discretion. this is an open-label, non-comparative, non-interventional, prospective, and multi-center study conducted in korean health care centers by accredited physicians (investigator). the study population is korean subjects who are scheduled for covid-19 vaccination. comirnaty injection (bretovameran) will be administered according to the "dosage and administration" of the authorized label. there is no visit or activity mandated by this study. the investigator will collect data from the subject's medical records and diary and record data on each subject's case report form (crf).

Eligibility criteria:
inclusion criteria: * korean subjects who are eligible for administration of comirnaty injection according to the locally authorized label * subjects with evidence of a personally signed and dated informed consent/assent document indicating that the subject (or a legally acceptable representative) has been informed of all pertinent aspects of the study exclusion criteria: * subjects who involved in the contraindications of use indicated in the locally authorized label * subjects with a history of hypersensitivity to any ingredients of this product or this product * any subjects (or a legally acceptable representative) who does not agree that pfizer and companies working with pfizer use his/her information

Keywords: covid-19 bretovameran adverse events sars-cov-2 safety
quality of life and sexual function of the novasure endometrial ablation in menorrhagia

Conditions: Quality of Life; Sexual Activity

Summary: the aim of this study is to investigate the influence on the quality of life and sexual function before, 6 month and one year after novasure endometrial ablation in the treatment of menorrhagia.

patients diagnosed menorrhagia scheduled for novasure endometrial ablation because of menorrhagia between november, 2012 and november, 2014 are enrolled to this study. patients are asked to complete preoperative questionnaires considering health related quality of life questionnaire(hrqol) and sexual female sexual functioning index questionnaire(fsfi). same questionnaires will also be completed six months and one year after operation.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of menorrhagia * family complete * normal endometrial pathology * had not been referred specifically for surgery * with normal uterine cavity exclusion criteria: * pregnancy or demand to preserve fertility * acute reproductive tract inflammation or urinary tract inflammation * pathology demonstrate endometrial cancer or precancerous change * acute pelvic inflammation * intrauterine device(iud) in uterus * depth of uterine cavity less than 4cm or more than 10cm * pathologic myometrium( such as history of hysteromyomectomy or classical cesarean section)

Keywords: quality of life sexual activity novasure endometrial ablation menorrhagia
the impact of arabic gamified mobile application on diabetes control in egyptian pediatric patients with type 1 diabetes.

Conditions: Diabetic Pediatric Patients With Type 1 Diabetes

Summary: this is a prospective randomized parallel two group pharmacist-led interventional study. the study will involve introduction of the mobile game to pediatric diabetic patients to improve their blood glucose level. the outcomes to be measured are diabetes control and behavioral change in pediatric patients with type1 diabetes mellitus


Eligibility criteria:
inclusion criteria: 1. pediatric patients age from 7 to 14 years old to be able to deal with and understand the game. 2. children previously diagnosed with type1 dm. 3. arabic speaker. 4. smart phone (android) access at home, either the mobile of the child or his/her parents. exclusion criteria: 1. severe cognitive or psychiatric conditions that prevent a patient from understanding the game. any disorder that significantly impairs the cognitive function of an individual to the point where normal functioning in society is impossible without treatment ,examples: dementia- developmental disorders-motor skills disorders- amnesia- substance induced cognitive impairment)25 2. diabetic pediatric patients at goal with hba1c \< 7.
efficacy study of acupuncture to treat spinal pain

Conditions: Low Back Pain

Summary: this study is being conducted to investigate the effectiveness and safety of acupuncture for alleviating pain of spondylosis.

this study is being conducted at the daegu catholic university medical center. enrolled participants will be randomized into two groups : acupuncture treatment plus epidural block and epidural block alone. this trial will include treatments during 3 weeks, and then follow up after 2 weeks. participants will have acupuncture treatments of three times per week and epidural block of once per week. all examinations and treatments will be provided free of charge. compared with epidural block group, acupuncture plus epidural block group will give more effectiveness for alleviate pain caused by lumbar spondylosis.

Eligibility criteria:
inclusion criteria: * age 18 to 65 years * meyerding grade i-ii spondylolisthesis * low back pain of at least 1-year duration * follow-up possible during the clinical trial * written informed consent voluntarily exclusion criteria: * cauda equina syndrome, persistently exacerbated symptoms, progressive neurologic signs (sensory or motor changes) * previous spine surgery * senile dementia, impaired cognitive function or other cerebral disease, severe psychiatric or psychological disorders * severe, concomitant disease (neuromuscular scoliosis, neurodegenerative disease) * all contraindications to corticosteroid injection (e.g., insulin-dependent diabetes) * alcohol/drug abuse * significant renal or hepatic disease * pregnant, lactating or planning a pregnancy * hypersensitive reaction to acupuncture treatment * inability to comprehend or express oneself in the korean language * an individual deemed to be ineligible by a physician * refusal to participate in the trial or to provide informed consent
a trial to investigate the bioequivalence of norditropin® (somatropin) versus genotropin® (somatropin) in healthy adult subjects

Conditions: Growth Disorder; Healthy

Summary: this trial is conducted in the united states of america (usa). the aim of the trial is to investigate the bioequivalence (the expected biological equivalence of two pharmaceutical drug products with identical active ingredient) of norditropin® (somatropin) versus genotropin® (somatropin) in healthy adult subjects.


Eligibility criteria:
inclusion criteria: * healthy subjects at trial entry with no previous exposure to recombinant human growth hormone or igf-i (insulin-like growth factor-i) * body mass index (bmi) 18.0-27.0 kg/m\^2 (both inclusive) * considered generally healthy upon completion of medical history, physical examination, vital signs, screening laboratory results, and electrocardiogram (ecg), as judged by the investigator exclusion criteria: * the receipt of any investigational medicinal product within 1 month prior to this trial * current or previous treatment with growth hormone or igf-i * female of childbearing potential who is pregnant, breast-feeding or intends to become pregnant or is not using adequate contraceptive methods (adequate contraceptive measures as required by local law or practice) for the duration of the trial * known presence or history of malignancy * diabetes mellitus * use of systemic corticosteroids * use of anabolic steroids * history of drug or alcohol abuse
self-reported outcomes of patients in eras nursing

Conditions: Enhanced Recovery After Surgery

Summary: we aimed to evaluate the effect of eras nursing program on self-reported outcomes of patients undergoing minimally invasive lung cancer surgery, and compared the differences in length of hospital stay, complications, and readmission rate between eras and non-eras nursing programs


Eligibility criteria:
inclusion criteria: * ≥18years,minimally invasive elective surgery,cooperate exclusion criteria: * pneumonectomy was performed and converted to open surgery surgery intensive care, unable to cooperate (language speech disorders, psychopathology)
lung cancer location: a repository

Conditions: Lung Cancer

Summary: the purpose of this repository is to prospectively examine subjects with known or suspected lung cancer to determine the extent of mediastinal lymph node involvement with respect to primary lung cancer location. the data collected in this repository may be used to influence our current standard of care and streamline indications for eus.


Eligibility criteria:
inclusion criteria: * subjects undergoing eus evaluation of a mediastinal mass, or suspected/known lung cancer * subjects with a prior history of lung cancer * subjects referred to thoracic surgery for evaluation of a suspected/known lung cancer exclusion criteria: * altered mental status that would prohibit the giving and understanding of informed consent * dementia * psychiatric illness that would preclude adequate compliance with communication for this protocol * prisoners