Kornimate/medical-research-clean huggingface dataset:
engage & connect: a psychotherapy for postpartum depression

Conditions: Postpartum Depression

Summary: this randomized controlled trial compares a novel psychotherapy, engage \& connect, with a symptom review and psychoeducation intervention, tailored to reduce postpartum depression. the study includes 9-weeks interventions, delivered remotely. it will examine changes in social isolation, processing of social rewards and depression severity over 9 weeks of treatment.

postpartum depression is linked with decreased motivation to seek rewarding activities and enjoyment of pleasurable experiences. social isolation and low perceived social support predict persistence of postpartum depression. engagement in rewarding social activities with significant others may increase motivation and enjoyment, motivating utilization of a therapy that addresses social isolation and reward response. the investigators developed engage \& connect (e\&c), a 9-week psychotherapy program that focuses on increasing meaningful social activities with significant others. this study will be a pilot randomized controlled trial that will compare the 9-week e\&c course for mothers with postpartum depression with a symptom review and psychoeducation condition (srp) for mothers with postpartum depression.

Eligibility criteria:
inclusion criteria: 1. up to 1 year post-delivery 2. edinburgh postnatal depression scale (epds) score ≥ 10. 3. off antidepressants or on a stable dose of an antidepressant for 8 weeks and do not intend to change the dose in the next 10 weeks. 4. capacity to provide consent for research assessment and treatment. 5. speaks english proficiently exclusion criteria: 1. intent or plan to attempt suicide in the near future 2. ongoing psychotherapy (no more than once every 8 weeks or during the duration of the intervention) 3. active substance abuse or dependence 4. severe fetal anomalies, stillbirth or infant death at time of enrollment for index pregnancy 5. history or presence of psychiatric diagnoses other than major depressive disorder without psychotic features, generalized anxiety disorder, persistent depressive disorder, or specific phobia. 6. use of psychotropic drugs or cholinesterase inhibitors other than use of ≤ 0.5 mg of lorazepam daily up to seven times per week.
point-of-care testing in outpatient diabetes care

Conditions: Diabetes

Summary: using a point-of-care (poc) platform, the investigators will investigate the effects of poc testing for glycated hemoglobin (hba1c) and cystatin c at out-patient clinics on long-term diabetes outcomes.

laboratory testing for hba1c and cystatin c is time-consuming, and healthcare providers often do not have update results when they evaluate outpatients with diabetes. a poc testing platform may help address this issue, and the investigators aim to examine its effects on diabetes outcomes.

Eligibility criteria:
inclusion criteria: -adults aged 18 to 80 receiving treatment and follow-up for diabetes at outpatient clinics of taichung veterans general hospital, taichung, taiwan. exclusion criteria: 1. past medical history of hemolytic anemia, hemoglobinopathies (sickle cell anemia hbs, fetal hemoglobin hbf), iron deficiency anemia, thalassemia, pernicious anemia, recent blood transfusions, acute bleeding requiring erythropoiesis-stimulating agents. 2. chronic liver disease, cirrhosis, hyperbilirubinemia, asplenia (splenomegaly, splenectomy). 3. hypertriglyceridemia (over 500 mg/dl), or alcoholism. 4. thyroid dysfunction, active malignant tumors under treatment, hiv infection. 5. long-term use (over three months) of steroids or cyclosporine. 6. severe proteinuria (e.g., nephrotic syndrome), or a baseline egfr \<60 ml/min/1.73 m².

Keywords: diabetes hba1c cystatin c point of care
the impact of soft contact lens attributes on symptoms associated with digital eye strain in symptomatic soft contact lens wearers

Conditions: Asthenopia; Myopia

Summary: despite its prevalence, the ocular causes of eye fatigue or unknown and may be related to the cornea/contact lens surface, the accommodative system, the convergence system, overall postural/muscle fatigue, or a combination of these or other causes. the current study aims to systematically investigate the incremental benefits in ameliorating eye fatigue.


Eligibility criteria:
inclusion criteria: 1. self-reported "eye fatigue" at least once per week attributable to digital device use with baseline. 2. uses a digital device (phone, tablet, computer, etc) at least 4 hours per day 3. mobile digital device with active data and text plan, able to receive email and text messages 4. habitual 2-week or monthly silicone single vision hydrogel soft contact lens use; habitually wearing lenses for 6 or more hours per day for 5 or more days per week for the past 30 days 5. habitual soft contact lens prescription optimized over-refraction within ±0.25 d 6. 18-35 years of age 7. the subject must appear able and willing to adhere to the instructions set forth in this clinical protocol. 8. vertex corrected refractive cylinder must be -0.75 or less. 9. visual acuity best correctable to 20/25 or better for each eye 10. the subject must read and sign the informed consent form. exclusion criteria: 1. a habitual wearer of any of the test lenses 2. any active conditions that may prevent soft contact lens wear. 3. any doctor diagnosed, self-reported ocular surface disease or dry eye requiring regular, ongoing treatment 4. any doctor diagnosed, self-reported accommodative or binocular vision issues 5. history of issues of eye alignment or binocularity by self-report

Keywords: eye fatigue
generic vs. name-brand levothyroxine

Conditions: Congenital Hypothyroidism; Hypothyroidism

Summary: this study compares two different brands of thyroxine (thyroid hormone). currently, pharmacists may be substituting generic formulations of thyroid hormone without your doctor knowing about this. although a small difference in thyroid function is not significant in most healthy children, adolescents and adults, in infants and toddlers even a small difference in thyroid function can have important harmful consequences on brain development. the purpose of the present study is to learn whether the difference between brands of thyroid hormone that are currently being substituted is sufficient to cause a difference in thyroid function.

this study is an unblinded, randomized controlled cross-over study, which involves taking 2 different forms of levothyroxine sequentially over a 16 week period. subjects will have a total of 3 visits over this time period. at the first visit, subjects are randomized to receive either generic (sandoz) levothyroxine or synthroid (abbott) brand of levothyroxine. blood is drawn for baseline thyroid function studies and other markers which are influenced by thyroid hormone at each visit. the second visit is the cross-over visit, and the final visit is a close-out visit, after which each subject will resume taking their previous formulation of levothyroxine.

Eligibility criteria:
inclusion criteria: * age between 3 and 18 years * diagnosis of congenital hypothyroidism with initial tsh \> 100 * ability to understand directions and follow all instructions exclusion criteria: * not on any drug interfering with absorption of levothyroxine
analgesic efficacy of multiple mid-transverse process to pleura (mtp) block and pca in idiopathic scoliosis patients undergoing posterior spinal fusion

Conditions: Multiple Mid-Transverse Process to Pleura; PCA; Idiopathic Scoliosis; Posterior Spinal Fusion

Summary: this study aims to compare the analgesic efficacy of multiple mid-transverse process to pleura (mtp) block and pca in idiopathic scoliosis patients undergoing posterior spinal fusion surgery.

the postoperative period for idiopathic scoliosis patients undergoing posterior spinal fusion (psf) is fraught with challenges, including adequate postoperative pain control and prolonged hospitalization. regional anesthesia techniques, mainly epidural analgesia and, more recently, paravertebral blocks, became crucial parts of the multimodal analgesia (mma) regimen after introducing ultrasound (us) in the regional anesthesia practice. erector spinae plane (esp) block and mid-transverse to pleura (mtp) block are the latest developments in postoperative pain therapy.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * both sexes. * american society of anesthesiology (asa) physical status i-ii. * idiopathic scoliosis patients undergoing posterior spinal fusion surgery. exclusion criteria: * patients with pre-existing infection at block site. * known allergy to study drugs. * coagulation disorder. * history of psychiatric illness. * pre-existing neurological deficits. * patient with morbid obesity (body mass index \>40 kg/m2). * presence of any pre-operative pain or history of chronic pain. * history of regular analgesic.
a phase i, study to evaluate the safety and tolerability of intravenous ezn-2208 in patients with advanced solid tumors or lymphoma (ezn-2208-02)

Conditions: Lymphoma; Advanced Solid Tumors

Summary: the goal of this clinical research study is to find the highest tolerable dose of ezn-2208 that can be given to patients with advanced cancer or lymphoma. the safety of the study drug and its effect on the disease will also be studied. enzon will also perform pharmacokinetic (pk) testing of ezn-2208. pk testing measures the amount of a drug in the body at different time points.


Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed diagnosis of advanced and/or metastatic solid tumor or lymphoma that is refractory to standard therapy * measurable or evaluable disease * score of 0 to 2 on the ecog performance scale exclusion criteria: * concurrent serious medical illness * known, clinically suspected, or history of central nervous system (cns) tumor involvement * active diarrhea * known history of coagulation disorder * patients requiring cytochrome p450 3a4 (cyp3a4) enzyme inducing medications * requirement for ketoconazole or other strong inhibitor of cyp3a4 enzymes * prior chemotherapy, immunotherapy, investigational agent, or other therapy used to treat the cancer within 4 weeks (6 weeks for prior treatment with mitomycin c or nitrosoureas) prior to the scheduled administration of ezn-2208.
an ecological approach to addressing childhood obesity issues in imperial county

Conditions: Childhood Obesity

Summary: our choice is one of three cord (childhood obesity research demonstration) studies funded by the centers for disease control and prevention in 2011 to test multi-sector, multi-level approaches to prevent and control childhood obesity. our choice is translating evidence-based approaches for modifying behaviors, policies, systems, and environments to promote fruit and vegetable consumption, physical activity, water consumption, and quality sleep. the ultimate goal is to assist children's health insurance program-eligible children between 2-12 years old attain a healthy weight. in addition to site-specific intervention and evaluation activities, our choice is working with the university of houston evaluation center to conduct a cross-site evaluation on a set of shared measures.

our choice is a partnership between a university-affiliated research institute, a federally qualified health center, and a county public health department. we used formative research, advisory committee members' recommendations, and previous research to inform the development of the our choice project. our theory-informed multi-sector, multi-level intervention targets improvements in four health behaviors: fruit, vegetable, and water consumption, physical activity, and sleep. intervention partners include 1200 families, a federally qualified health center (including three clinics), 26 early care and education centers, two elementary school districts (and 20 elementary schools), three community recreation centers, and three restaurants. intervention components in all sectors target changes in behaviors, policies, systems, and the social and physical environment. evaluation activities include assessment of the primary outcome, bmi z-score, at baseline, 12- and 18-months post-baseline, and sector evaluations at baseline, 12, and 24-months.

Eligibility criteria:
inclusion criteria: * if family had school-age child, child must attend one of the designated our choice schools located in one of three designated cities. * if family had preschool-age child, family must reside in one of three designated cities. * children ages 2-11 years old * maximum two children per household * children above the 5th percentile body mass index * family agrees to remain in the area throughout the duration of the study * participating parent had to understand english or spanish exclusion criteria: * child has any condition that significantly limits eating or physical activity in a way that interventions would be impacted

Keywords: childhood obesity latino hispanic
characterization of fatty acid composition of triglycerides in patients with hypertriglyceridemia-induced acute pancreatitis

Conditions: Hypertriglyceridemia

Summary: ) finding a unique pattern in the triglyceride composition of patients with hypertriglyceridemia that increases the chances of getting pancreatitis and which can serve as a laboratory predictive tool for patients and define them as a at-risk population. 2) finding the typical fatty acid composition in triglycerides for patients at high risk of pancreatic acute inflammation that can be used to develop unique drugs for pancreatic acute inflammation caused by high levels of triglycerides.

the study will be conducted at the sheba medical center lipid institute, number of participants: 10 healthy participants, 10 participants with hypertriglyceridemia without prior pancreatitis and 10 participants with hypertriglyceridemia and at least one case of severe pancreatitis in the last 5 years. a total of 30 participants participants who are found suitable during their visit to the lipid institute clinic or during their hospitalization at sheba medical center will receive an explanation of the study, will be asked to sign a consent form. and check the fatty acid levels. healthy volunteers who meet the inclusion conditions will also be asked to sign a consent form and their blood will be taken and kept frozen for further study

Eligibility criteria:
inclusion criteria: * 1) healthy participants - triglyceride levels\< 150 mg / dl over the past 5 years, with no diabetes or cardiovascular disease in the background. 2) participants with triglyceride levels 1000-5000 mg / dl without acute pancreatitis cases in the past. 3) participants with triglyceride levels 1000-5000 mg / dl and at least one case of acute pancreatitis in the last 5 years. exclusion criteria: 1. a past pancreatitis event that occurred with measurement of triglyceride levels greater than 5000 mg / dl. 2. acute pancreatitis events in the past that occurred for a cause other than hypertriglyceridemia -
study of the absorption of vitamin e water-soluble form (pegylated) in the familial hypocholesterolemia with chylomicron retention

Conditions: Hypobetalipoproteinemias

Summary: to evaluate the kinetics of intestinal absorption of vitamin e water-soluble form from the classical lipid-soluble form in a population of patients with intestinal malabsorption (hypocholesterolemias family by retention of chylomicrons).


Eligibility criteria:
inclusion criteria: * patient suffering from familial hypocholesterolemia by retention of chylomicrons * systematically followed in the department of gastroenterology and paediatric nutrition in women mother child's hospital or in the endocrinology department of ghe (louis pradel hospital); * during treatment with oral vitamin e; * over the age of 3 years and weighing over 16 kg at the time of inclusion * for which there is a signed informed consent from the patient or parents / guardians in the case of a minor patient, and benefit from social security coverage. exclusion criteria: * patient with encephalopathy * hypersensitivity to the active substance or the excipients of vedrop * a suspected allergy to local anaesthetics (including xylocaine) * patients who may not be compliant to treatment (psychiatric); * in case of refusal to participate in the study from the patient and / or parents or legal guardian; * patients unable to consent (if patients with encephalopathy)

Keywords: vitamin e pegylated chylomicron retention familial hypocholesterolemia hypobetalipoproteinemias
whole body vibration therapy in a participant with multiple sclerosis related balance deficits - a case study

Conditions: Multiple Sclerosis

Summary: the purpose of this investigation is to determine the effect of whole body vibration therapy (wbv) on balance in a participant with multiple sclerosis (ms) related balance deficits as measured by the neurocom balance master, the sapphire iime emg device and the kurtzke expanded disability status scale (edss) and the berg balance score.


Eligibility criteria:
inclusion criteria: logan student, staff, or faculty or general public with a minimal of 2 year history of diagnosed multiple sclerosis (ms) exclusion criteria: 1)visual or vestibular condition that would affect balance; 2) non-ms related systemic illness that would have an adverse effect on balance; 3) local infection, acute inflammation, injury, tumors or other malignancy, recent wounds, diabetes; 4) any unstable joints of the lower extremity, recent hip and knee joints or fitted hip or knee pins, bolts and/or plates; 5) acute thrombosis; 6) severe migraine, epilepsy; 7) serious cardiovascular disease, wearing a pacemaker; any spinal manipulation within 48 hours; 8) acute disc herniation, discopathy or spondylolysis; 9) prescription or herbal muscle stimulants, relaxants, etc. that could affect balance; 10) any implanted device or prosthesis or intrauterine iud type of device; 11) pregnancy
knowledge and attitude of pregnant women towards preeclampsia in assiut governorate

Conditions: Preeclampsia

Summary: our study will be a cross sectional study to evaluate the knowledge level and attitude of pregnant women towards preeclampsia and factors affecting it ,the study will be done at assiut university hospitals - women's health hospital. all pregnant women who will come to anc visits will be included .the study tool is a well structured questionnaire for assessment of our outcomes.

preeclampsia is a pregnancy-related hypertensive disorder that usually occurs after 20 weeks of gestation. it is characterised by hypertension and proteinuria . preeclampsia is the leading cause of maternal death, complicating about one-tenth of all pregnancies worldwide . it is the second greatest cause of direct maternal death, accounting for 70,000 maternal mortality globally each year .the burden of preeclampsia and eclampsia is most significant in low- and middle-income countries (lmics), where hypertensive disorders of pregnancy account for 10-15% of maternal deaths. early detection of symptoms, rapid presentation to healthcare facilities, and subsequent management with antihypertensive medications, magnesium sulphate, and delivery of the foetus and placenta improve outcomes in pregnancies complicated by preeclampsia and eclampsia . as a result, anc visits and intrapartum admission are critical chances for patient counselling despite the essential relationship between women's awareness of preeclampsia and health seeking behaviour, research on this topic is limited, particularly in underdeveloped countries. even in developed countries, studies in high-income countries show that only half of patients were counselled about preeclampsia signs and symptoms, despite the fact that counselling by healthcare personnel is related to higher patient knowledge. so there is a gap in studying pregnant women's knowledge and attitudes concerning preeclampsia in underdeveloped countries, particularly egypt, where studies on this topic are scarce.

Eligibility criteria:
inclusion criteria: * all pregnant women. * pregnant women in first, second and third trimester. * pregnant women who come to receive anc at assiut university hospitals - women's health hospital out patient clinic. exclusion criteria: * pregnant women that are unwell to give consent. * pregnant women who are already diagnosed by preeclampsia and eclampsia.
pet imaging in potentially surgically resectable non-small cell lung cancers

Conditions: Non-small-cell Lung Carcinoma

Summary: lung cancer remains the leading cause of cancer deaths in men and women. although overall survival remains poor, early stage non-small cell lung cancer (nsclc) is potentially curable. improved staging has led to stage-specific therapies such that patients with early stage nsclc are potential candidates for surgical resection, and those with more advanced disease are spared the morbidity and risk of mortality from thoracotomy and pulmonary resection. despite contemporary staging techniques, 25-50% of patients who appear to have limited disease amenable to surgical resection go on to die from metastatic lung cancer. if occult micro-metastatic disease that becomes evident later could be detected reliably during the pre-operative assessment, patients harboring such disease could be spared a non-curative thoracotomy. pet imaging has the potential to detect mediastinal and extrathoracic metastatic disease not detected by conventional imaging modalities. this prospective, multicenter trial will enroll patients with biopsy-proven clinical stage i-iiia nsclc who are considered to be candidates for surgical resection with curative intent. preoperatively, patients will be randomized to conventional staging for metastatic disease (ct liver/adrenals, total body bone scan, and ct with contrast or mri with gadolinium of the brain) versus whole body pet or pet-ct and brain ct or mri with contrast/gadolinium.


Eligibility criteria:
inclusion criteria: * histological or cytological proof of nsclc * stage i, ii, or iiia nsclc based upon clinical staging * the primary lesion appears technically appropriate for surgical resection, based on information from the chest x-ray (cxr) and ct thorax. * age over 18 years exclusion criteria: * poor pulmonary function precluding radical surgery (inadequate pulmonary reserve for radical surgery) with predicted post-resection forced expiratory volume in 1 second (fev1) \< 0.8 liter or \< 40% predicted, and diffusing capacity of the lung for carbon monoxide (dlco) \< 40% predicted * poor performance status (eastern cooperative oncology group \[ecog\] 3-4) * significant concurrent medical problems (e.g. uncontrolled diabetes, active cardiac problems, significant chronic obstructive pulmonary disease) making the patient unfit for surgery * pregnant or lactating females * unable to lie supine for imaging with pet * patients with previously treated cancer other than non-melanotic skin cancer or carcinoma in situ of the cervix, unless disease-free for 5 years or greater * patients who, at the time of the initial evaluation, have already undergone a whole body pet/pet-ct, ct brain, mri brain, total body bone scan or mediastinoscopy within 8 weeks prior to randomization will be excluded. however, patients who have had a ct scan of the thorax with abdomen are not excluded. * failure to provide informed consent

Keywords: positron-emission tomography pet scan lung cancer thoracic surgery diagnostic randomized controlled trial oncology
impact of the excess weight loss on mineralization patterns of the knee after bariatric operations

Conditions: Obesity; Weight Loss; Knee Osteoarthritis

Summary: evaluation of the subchondral mineralization plate after excess weight loss in patientes undergoing bariatric operation by means of ct-osteoabsorptiometry.


Eligibility criteria:
inclusion criteria: * bmi \> 35 * need for bariatric operation * knee pain (vas \> 2) exclusion criteria: * malignancy * poor compliance * previous bariatric operation * pregnancy * lack of knee pain (vac \< 2) * previous knee operation

Keywords: obesity weight loss knee osteoarthritis subchondral mineralization