Kornimate/medical-research-clean huggingface dataset:
can we predict coronary resistance by eye examination ? (coreye)

Conditions: Coronary Artery Disease

Summary: prospective interventional study, open, non-comparative and non-randomized. the research concerns physiological parameters of the coronary and ocular blood circulation. at the coronary level, the curves of pressure and doppler flow will be extracted from combomap® (philips). the coronary microvascular resistances, basal and hyperemic, will be determined by the average ratio of the distal pressure and flow. at the ocular level, a fundus oculi and an octa (angiography by tomography in optical coherence) examination will be performed. the measures of the ffr and the coronary microvascular resistance will be determined by a guidewire allowing measures of pressure and by a guidewire allowing measures of doppler flow (combowire®, volcano), in 123 patients with intermediate stenosis of the left anterior descending artery (lda). topological parameters characterizing the retinal area and choriocapillaries will be determined by statistical approaches and mathematical morphology. to establish a predictor of the coronary microvascular resistance from the eye vascular parameters, we shall use a non-linear regression by supervised machine learning. the main cardiovascular risk factors (hypertension, diabetes, dyslipidemia, age, sex) will be part of predetermined input features for the machine learning.


Eligibility criteria:
inclusion criteria: 1. male and female patient's ≥18 years of age with coronary arterial indication as usual and with proximal and / or mean iva stenosis ≥ 50%. 2. signed informed consent 3. affiliation to the social security system exclusion criteria: 1. unstable coronary artery disease 2. atrial fibrillation 3. history of myocardial infarction \<6 months in the territory of the proximal and / or mean iva. 4. asthma 5. aortocoronary bypass surgery. 6. collateral development at the level of the proximal and / or mean iva. 7. allergy to iodine, severe renal insufficiency. 8. ametropia\> = 6 diopters. 9. history of retinal ocular pathologies other than uncomplicated diabetic retinopathy and hypertensive retinopathy. 10. history of ophthalmic treatments such as macular or panretinal laser photocoagulation, intravitreal injection of anti-vegf or cortisone. 11. chronic glaucoma 12. patients under guardianship or curators. 13. pregnant or lactating women. 14. patient's not affiliated to the french social security. 15. persons placed under the protection of justice, 16. subject participating in another research including an exclusion period still in progress at pre-inclusion
local anesthesia and tuberculin skin test in infants and children

Conditions: Tuberculosis

Summary: the use of local anaesthesia efficiently reduces pain due to needle puncture. however, when tuberculin skin test is performed it is the skin reaction to tuberculin injection that is studied. it is a quantitative skin reaction measured in millimiters. from the study of literature it is not known whether local anaesthetic modify skin reaction to tuberculin. therefore, before recommending the use local anaesthesia for tuberculin intradermal injection we have to rule out a potential effect of local anaesthetic on the result of the test. this is particularly important in children, since there are more sensitive to pain than adults


Eligibility criteria:
inclusion criteria: hospitalized or non hospitalized infant or child (3 months-15 years)requiring a tuberculin skin test, in our hospital. hospitalized 1 to 3 months old infants requiring a tuberculin skin test, in our hospital. - exclusion criteria: * child with contra indication to the use of lidocaine / prilocaine * child with evolutive dermatitis on forearms * premature or newborn (less than 1 month of age) * infants (1 - 24 months of age)who has yet received repeated local anaesthesia (at least 2)during the 24 previous hours * infants (1 - 24 months of age)who is treated with a drug that could enhance the risk of methhaemoglobinemia * child with previous evere local reaction to tuberculin injection (necrosis,ulceration) * child with history of tuberculosis disease * child with hepatic failure * parents or the child himself if lod enough, have not given their agreement for the study

Keywords: tuberculosis, tuberculin, childhood, pain
feasibility of end-tidal oxygen concentration monitoring during preoxygenation for intubation in the intensive care unit.

Conditions: Critically Ill

Summary: intubation is a common procedure in the intensive care unit. hypoxemia is the most frequent complication of this procedure. monitoring the end-tidal of oxygen is recommended in operating room (or). end-tidal of oxygen (eto2) \>90% is an indication of a correct preoxygenation. this monitoring is not used in routine in intensive care unit (icu). there is no recommendation on the monitoring of end-tidal of oxygen in intensive care unit. in practice, clinicians use pulsed oxygen saturation (spo2) to determine whether the patient is sufficiently preoxygenated. however, this parameter is not a good indicator of a correct preoxygenation. in the or, patients are compliant during the preoxygenation period and the measure of eto2 with the face mask monitor is considered reliable because i) mask leakage is minimal and ii) the patient can breathe slowly and regularly. theses conditions are not available in critical ill patients requiring emergency intubation. eto2 measured on the facemask may not reflect true eto2. this concern about the reliability of eto2 measurement via the facemask justifies that we conduct a study to compare eto2 measured on a facemask (facemask eto2) to eto2 measured in pharynx (via e nasopharyngeal catheter). the aim of this study is to determine whether the measurement of eto2 on facemask is reliable in patients in icu.

this is a prospective non-comparative interventional study. a double monitoring of eto2 will be performed during the procedure of intubation (from the beginning of the preoxygenation to the success of intubation): * in the pharynx (via a nasopharyngeal catheter) for the needs of the study * on the facemask (as the practice in the or) the duration of the study will not exceed one hour, including the installation of the devices.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * requiring an intubation in icu for acute respiratory failure defined as a respiratory rate ≥ 25/min or clinical signs of respiratory distress or hypoxemia defined as oxygen requirement ≥ 15l/min or fio2 ≥80% to maintain spo2 ≥92% or a pao2/fio2 ratio \<100 mmhg * with preoxygenation by noninvasive ventilation exclusion criteria: * intubation for cardiac arrest * eto2 monitoring not available * pulsed oxygen saturation monitoring specific for the study not available * preoxygenation by high-flow nasal oxygen therapy or bag-mask ventilation * allergy to lidocaine (for local nasal anesthesia) * previously * patient not affiliated or excluded from social protection, or under law protection (namely minors, pregnant or breastfeeding women, persons deprived of their liberty by court or administrative decision) * previously included in the study

Keywords: preoxygenation intubation end-tidal of oxygen intensive care unit critically ill patients
intermittent mechanical compression for peripheral arterial disease

Conditions: Peripheral Arterial Disease

Summary: the study tests the use of a portable mechanical compression device (fm220, flowmedic, usa) for the treatment of claudication and peripheral arterial disease. major endpoints are improved exercise tolerance and relevant blood pressure ratios


Eligibility criteria:
inclusion criteria: * stable claudication with an absolute claudication distance \>40 meters but \<300 * resting abi in the affected limb \<0.8 exclusion criteria: * presence of diabetes

Keywords: claudication peripheral arterial disease intermittent compression mechanical compression flowmedic
a study to evaluate suppression of the pituitary-ovarian axis with three different oral contraceptive regimens

Conditions: Healthy

Summary: this is a randomized, open-label study to evaluate pituitary ovarian suppression in healthy, reproductive-aged women using three different regimens of oral contraceptives (ocs). two extended regimen ocs, seasonale (levonorgestrel/ethinyl estradiol 0.15/0.03 mg for 84 days followed by 7 days of placebo), and seasonique (levonorgestrel/ethinyl estradiol 0.15/0.03 mg for 84 days followed by 7 days of ethinyl estradiol 0.01 mg), and a 28-day regimen oc, portia (levonorgestrel/ethinyl estradiol 0.15/0.03 mg for 21 days followed by 7 days of placebo).


Eligibility criteria:
inclusion criteria: * premenopausal * not pregnant or breastfeeding * weight \<200 lbs * currently taking oral contraceptives in the standard 28-day regimen for at least two months exclusion criteria: * any contraindication to the use of oral contraceptives * pregnancy within the last 3 months * smoking \> 10 cigarettes per day
testing cognitive functions in patients with copd using a driving simulator

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: little is known about the causes and degree of cognitive dysfunction in patients with chronic obstructive pulmonary disease (copd), especially their driving abilities. the purpose of the study is to examine the cognitive skills of patients with copd by using a driving simulator and to examine correlations to factors that may predict cognitive dysfunction in these patients.


Eligibility criteria:
inclusion criteria: * a diagnosis of copd (forced expiratory volume in 1 second (fev1) / forced vital capacity (fvc) \< 0,70) * no exacerbations within the last 6 weeks * valid driver's license and having driven a car within the last 3 months exclusion criteria: * lacking the ability to use the driving simulator * no valid driver's license * alcohol abuse (\> 21 units per week) * a known diagnosis of obstructive sleep apnea * uncorrected impaired vision or hearing * unstable ischemic heart disease, left-sided heart failure, severe neurologic diseases, cancer, severe peripheral vascular disease, severe psychiatric diseases, former apoplexia and uncontrolled hypertension, thyroid diseases or diabetes
radiotherapy of motor deficits from metastatic epidural spinal cord compression

Conditions: Metastatic Epidural Spinal Cord Compression

Summary: the primary aim of this randomized multi-center trial is to investigate the efficacy of the radiotherapy regimens 5 x 4 gy and 10 x 3 gy with respect to the effect on motor function in patients with metastatic epidural spinal cord compression.

the primary aim of this randomized multi-center trial is to investigate the efficacy of the radiotherapy regimens 5 x 4 gy and 10 x 3 gy with respect to the effect on motor function in patients with metastatic epidural spinal cord compression. the response rate (improvement in motor function or prevention of progression) will be assessed at one month following radiotherapy. in addition, the following endpoints will be evaluated: 1. motor function; additional assessments directly and at 3 and at 6 months after radiotherapy 2. ability to walk; assessment directly and at 1, 3 and 6 months after radiotherapy 3. sensory function; assessment directly and at 1, 3 and 6 months after radiotherapy 4. quality of life; evaluation directly and at 1, 3 and 6 months after radiotherapy 5. pain assessment directly and at 1, 3 and 6 months after radiotherapy 6. overall survival up to 6 months following radiotherapy 7. local progression-free survival up to 6 months following radiotherapy

Eligibility criteria:
inclusion criteria: * motor deficits of the lower extremities resulting from metastatic epidural spinal cord compression, which have persisted for no longer than 30 days * confirmation of diagnosis by magnetic resonance imaging (spinal computed tomography allowed) * relatively poor survival prognosis (defined as ≤35 points on the survival score published in cancer 2008) * written informed consent exclusion criteria: * prior radiotherapy or surgery of the spinal areas affected by mescc * history of symptomatic brain tumor or symptomatic brain metastases * metastases of the cervical spine only * other severe neurological disorders * pregnancy, lactation * indication for decompressive surgery + stabilization of the affected spinal areas

Keywords: metastatic epidural spinal cord compression motor function ambulatory status pain quality of life overall survival local control toxicity
covid-19 in hospitalised norwegian children - risk factors, outcomes and immunology

Conditions: Pediatric Respiratory Diseases; COVID; Fatigue Post Viral

Summary: prospective cohort study of covid-19 infection among children in norway.

this nation-wide, prospective cohort study of covid-19 infection addresses three main issues: 1) epidemiological risk factors; 2) natural history (including immunological mechanisms and long term effects) and 3) support of infection prevention. also, the study focuses solely on children. children (0-18 years of age) admitted to hospital with suspected covid-19 are eligible (fig. 1). those with confirmed covid-19 serve as cases, whereas those with non-covid-19 serve as controls; both groups will be followed prospectively for 6 months. three objectives/work packages (wps) are defined: * in wp1, the investigators will investigate risk factors for severe outcome of the acute infection; potential risk factors include sex, age, comorbidities, initial clinical findings, infectious load, and genetic markers. * in wp2, the investigators will investigate the immunological response to acute infection, focusing on initial innate host response and its associations to inflammatory enhancement, genetic factors and clinical course. * in wp3, the investigators will investigate the prevalence and risk factors of long-lasting complication, in particular the development of post-infectious chronic fatigue

Eligibility criteria:
inclusion criteria: suspected covid-19 infection and age 0-18 years exclusion criteria: age \>18 years
a study for patients with osteoporosis

Conditions: Osteoporosis

Summary: the purpose of this study is to compare the effect of injectable teriparatide to intranasal salmon calcitonin on lumbar spine bone mineral density, in the treatment of chinese patients with established osteoporosis


Eligibility criteria:
inclusion criteria: * clinical diagnosis of osteoporosis * no other severe disabling conditions * should have at least 1 vertebral or non-vertebral prevalent fracture, and bone mineral density t-score should be less than -2.5 * ambulatory * men (aged 40 to 85 years) or postmenopausal women (aged 55 to 85 years) exclusion criteria: * history of a disease that affects bone metabolism * history of treatment with any drug that may significantly affect bone metabolism * history or presence of liver disease * history or presence of kidney disease * history of excessive alcohol drinking or drug abuse
common bile duct pressure after surgical exploration

Conditions: Choledocholithiasis

Summary: a study that included patients of any gender between 15 and 70 years, with the diagnosis of choledocholithiasis who required a cholecystectomy with an exploration of bile ducts. conventional cholecystectomy was performed and a t-tube was inserted in the common bile duct (cbd) to measure the intraluminal pressure immediately after the procedure, and weekly thereafter, with a 6-week follow-up. a control t-tube radiological study was performed at six weeks to exclude residual stones.

a clinical, controlled, prospective, longitudinal, descriptive, observational and double-blinded study was designed. patients of any gender between 15 and 70 years, with a diagnosis of choledocholithiasis, and who required a cholecystectomy with an exploration of bile ducts were included. conventional cholecystectomy was performed and perioperative t-tube cbd pressure was registered immediately after the procedure, and weekly thereafter, with a 6-week follow-up. control t-tube cholangiogram was performed at six weeks to exclude residual stones. data was analyzed with t-test for parametric values.

Eligibility criteria:
inclusion criteria: choledocholithiasis - exclusion criteria: to not complete the follow-up period -

Keywords: choledocholithiasis; common bile duct; cholangiogram.
practical usability of egfr mutation detection in ctdna from resectable nsclc

Conditions: Lung Neoplasms

Summary: the aim of the study is to assess the practical usability of egfr mutation detection in ctdna from early nsclc.


Eligibility criteria:
inclusion criteria: * patient with clinical stage ib to iiia non-small cell lung cancer * patients with resectable lung cancer * one of followings: 1) never-smokers or ex-smokers who quit 10 years ago, 2) female 3) subsolid nodule in chest ct 4) biopsy-proven adenocarcinoma exclusion criteria: * patients with metastatic lung cancer (stage iiib-iv) * patients who underwent chemotherapy or radiotherapy * patients with other malignancies
r(+)ppx high dose treatment of als

Conditions: Amyotrophic Lateral Sclerosis

Summary: r(+)pramipexole is administered in escalating doses to patients with early als. plasma and spinal fluid levels of r(+)ppx are monitored, in addition to biochemical markers of oxidative stress.


Eligibility criteria:
inclusion criteria: * definite als no prior exposure to r(+)ppx exclusion criteria: * alsfrs at baseline \<40 fvc at baseline \<70%

Keywords: neuroprotection oxidative stress
a pilot study on usefulness of probe-based confocal laser endomicroscopy targeted gastric biopsy

Conditions: Gastric Cancer

Summary: the purpose of this study is to conduct a study on genetic pathology, obtaining of pure cancer tissues is mandatory. although the endoscopy with biopsy has been a gold standard for diagnosing gastric cancer, percentage of cancer cells in biopsy samples is usually 30% or less. recently, confocal laser endomicroscopy has been introduced for real-time histopathologic diagnosis in various cancers. the investigators aim to evaluate that biopsy using probe-based confocal laser endomicroscopy will increase the percentage of cancer cells in biopsy samples.


Eligibility criteria:
inclusion criteria: 1. age, between 20 and 80 2. initial-onset gastric cancer which would be treated with surgery exclusion criteria: 1. previous subtotal gastrectomy 2. pregnancy or breast milk feeding 3. active infection 4. significant cardiopulmonary disease 5. active hepatitis or severe hepatic dysfunction 6. severe renal dysfunction 7. severe bone marrow dysfunction 8. severe neurologic or psychotic disorder
hyperpolarized noble gas mr imaging for pulmonary disorders

Conditions: COPD; Cystic Fibrosis; Asthma; Healthy

Summary: the purpose of this study is to test the efficacy of hyperpolarized helium-3 gas in mr imaging in copd, asthmatics, cf and healthy volunteers.

current pulmonary imaging techniques are clinically regulated to machines that produce radiation. mr which does not produce radiation was not possible due to the low concentration of fluids in the open spaces of the lungs. with hyperpolarized noble gases we can now use the safe techniques of mr imaging to view the airways of the lungs, thus limiting human exposure to radiation. this technique has already been proven to be possible in human subjects but there is insufficient data show its efficacy in a clinical setting. this study is designed to image a variety of pulmonary disorders to better find possible clinical uses for hyperpolarized gas mri.

Eligibility criteria:
inclusion criteria: * are male or female and are 5 years or older * consent/assent from the patient * have been diagnosed with a pulmonary disease such as copd, asthma, or cystic fibrosis. or healthy individuals. * must be able to hold their breath for up to 15 seconds exclusion criteria: * have any contraindications to an mr exam such as a pace-maker, metallic cardiac valves, magnetic material (i.e., surgical clips) implanted electronic infusion pumps or any other conditions that would preclude proximity to a strong magnetic field; * are undergoing the mr exam in an emergency situation * are pregnant or become pregnant at any point within the study time. * people with psychiatric disorders will be excluded from the study. * are claustrophobic and can not tolerate the imaging. * uses supplemental oxygen

Keywords: helium mri hyperpolarized helium hyperpolarized noble gas
pc protocol: preconceptional screening

Conditions: Infertility

Summary: background: despite considerable progress in the field of assisted reproductive technology (art) maximum pregnancy rates generally do not exceed 30%. furthermore, substantial differences in pregnancy rates are seen between women starting art from seemingly similar clinical starting points and information on pregnancy/neonatal complications after art is limited. for physicians and patients it would be extremely valuable if tools could be developed through which individualised chances of live birth and the development of pregnancy/neonatal complications can be calculated. in addition, there is increasing knowledge about health risks associated with subfertility and in particular with polycystic ovarian syndrome (pcos) and premature ovarian failure (pof). an important void in research to date is the absence of a control group to check important new findings. objectives: the study protocol aims to form a cohort of normo-ovulatory women with a regular indication for art which can aid the investigators principle lines of research: 1. to study initial predictors of ovarian response to stimulation for ivf 2. to study predictors of chances for live birth after repeated ivf cycles 3. to assess the role for vascular health in the probabilities of success in art treatment 4. to study predictors for pregnancy and neonatal complications 5. to form a control group for cycle disturbance studies study design: in this part of the protocol, serum and material for dna analysis will be collected by asking patients to have 20 ml of blood drawn during a routine blood withdrawal. this blood will be stored in the biobank of the umc utrecht at -80 c. study population: all women starting art will be asked to participate. women starting donorinsemination treatment will be asked to participate, from the viewpoint that they potentially will form a normal fertile control group. nature and extent of the burden and benefits associated with participation: there are no benefits or risks for the study patient as blood is withdrawn during a routine venapuncture and results will not be used for clinical practice.

the aim of this protocol is to collect serum and genotype from normo-ovulatory women with a regular indication for ivf/icsi that can aid further research into the investigators principle lines of research which include improving performance art treatment , limiting pregnancy complications, and improving offspring health.

Eligibility criteria:
inclusion criteria: * normo-ovulatory with a regular indication for art or undergoing donorinsemination exclusion criteria: * women with cycle disturbances