Kornimate/medical-research-clean huggingface dataset:
dopamine transporter density profiles in patients with periodic limb movements

Conditions: Periodic Limb Movements in Sleep

Summary: restless legs syndrome and periodic limb movement (plm)are sleep-related movement disorders and studies have shown changes in striatal dopaminergic activity in patients with these disorders. physical exercise has been shown to improve the symptoms of restless legs syndrome and plm, as has treatment with dopamine agonists. however, the mechanism by which physical exercise acts as a non-pharmacological treatment in improving symptoms of restless legs syndrome and plm remains unknown. the investigators evaluated dopamine transporter density profiles in 16 sedentary patients (control and experimental - with plm, groups) and the influence of acute physical exercise on its concentration after a maximal exercise test. each patient underwent baseline polysomnography to evaluate sleep patterns and plm index values. after obtaining the polysomnography baseline, the single photon emission computer tomography baseline was determined. subsequently, the volunteers performed a maximal exercise test in the morning, followed by a single photon emission computer tomography two hours later and polysomnography that night, to assess the effect of acute physical exercise on dopamine transporter and sleep patterns. the results showed significant lower dopamine transporter baseline densities in the striatum region for the experimental group. the results also showed a significant reduction in the periodic leg movement rate in the experimental group and a significant increased percentage of stage-1 non-rem sleep in both groups after maximal exercise test. significant differences between the groups were only observed for stage 2 sleep and slow wave sleep. our results show that patients with plm had a lower dopamine transporter density in the left putamen region compared to the control group and an acute physical exercise (maximal exercise test) did not alter this profile, providing evidence that this improvement is the result of chronic physical exercise.

experimental design each volunteer (in both control and experimental groups) underwent polysomnography (psg) adaptation. after one week, a baseline cerebral spect was performed (1-3pm) and a baseline psg was performed that night to evaluate the sleep pattern and the plm index. subsequently (after one week), each subject underwent a maximal exercise test (met) in the morning (11am to 1pm) after which spect examination was performed in the afternoon (1-3 pm). a psg was then performed that night to evaluate the effect of acute exercise on dat density and sleep pattern (figure 1).

Eligibility criteria:
inclusion criteria: * with and without plm, * no other health problems, * sedentary exclusion criteria: * other clinical and neurological conditions, * continuous pharmacological treatment

Keywords: plm dopamine physical exercise
prophylactic prp in moderate npdr

Conditions: Eye Diseases; Diabetes; Diabetic Retinopathy

Summary: diabetic retinopathy (dr) is a challenge to ophthalmic practice in communities with poor socioeconomic development. the covid 19 pandemic has accentuated the challenge. dr is one of the leading causes of vision loss worldwide, estimated to account for 1.25% of moderate to severe visual impairment and 1.07% of blindness. pan retinal photocoagulation (prp) remains the gold standard treatment for preventing visual loss in pdr. scatter photocoagulation is not recommended for eyes with mild or moderate non-proliferative diabetic retinopathy (npdr) provided careful follow-up can be maintained,. when retinopathy is more severe, scatter photocoagulation should be considered and should not be delayed if the eye has reached the high-risk proliferative stage. as many as 27% of patients with moderate npdr are estimated to progress to pdr in 1 year; therefore, they should be seen every 4 to 8 months. this ideal, good as it is, is not what ophthalmic practice has to deal with in communities of low-resource settings, where patients often seek medical advice due to visual complaints from the complications of pdr without being diagnosed in the non-proliferative stage or high risk pdr. screening protocols are not followed, a situation aggravated during the covid pandemic lockdown.


Eligibility criteria:
inclusion criteria: patients with moderate npdr at high risk which includ: * patients with pdr in the other eye * patients whose glycosylated haemoglobin (hba1c) more than 8 %. * patients with early cataract * patients on regular renal dialysis or with impaired renal function * patients with restricted mobility because of neurological or orthopedic conditions * patients dependent on others, including old age. * women in rural areas, who are dependent on the accompaniment of a male relative. exclusion criteria: * any patient who or whose relatives confirmed their attendance for regular follow-up according to the planned schedules after being informed of the possible complications which could happen if he or she did not attend. * patients with clinically significant macular edema (csme).
"effect of screening using imaging (ct/ eus) on early detection of pancreatic ductal adenocarcinoma (pdac) in patients with new onset diabetes (nod)" - a prospective pilot observational study

Conditions: Pancreatic Ductal Adenocarcinoma (PDAC)

Summary: to assess whether eus (endoscopic ultrasound) can serve as a valuable diagnostic tool for identifying pdac at an early stage in individuals who have recently been diagnosed with diabetes. purpose: to improve the rates of early detection of pancreatic cancer. pancreatic ductal adenocarcinoma (pdac) is a type of cancer that starts in the pancreas, a gland located in your abdomen. it happens when some cells in the pancreas start growing abnormally and form a cancer.


Eligibility criteria:
inclusion criteria: * age \> 50 years * patients diagnosed with diabetes based on fbs/ ppbs/ hba1c * presence of atleast 1 fbs parameter measured in the past 6-18 months which was not \> 125 mg/dl * end-pdac score \> 2 exclusion criteria: * known or newly detected chronic pancreatitis * past history of pancreatic cancer * history of steroid use * contraindications for eus
effect of aminobiphosphonates and statins on circulating vgamma9vdelta2-t cells

Conditions: Bone Metastases of a Malignant Tumor

Summary: the purpose of this study is to investigate the effects of aminobiphosphonate treatment on the phenotype and function of circulating vgamma9vdelta2-t cells and to determine whether these effects are inhibited by simultaneous treatment with statins.

a total of 40 patients will be entered in this study. half of the patients will receive standard intravenous treatment with aminobsiphosphonates, the other half will be additionally be treated with a statin. patients already receiving statin treatment will continue this treatment, other patients will be asked whether they are willing to be treated with a statin for a maximum of 5 weeks. consenting patients will be randomized to receive i.v. aminobisphosponates plus or minus simvastatin 40 mg once daily. simvastatin will be started one week prior to the first administration of aminobisphosphonates and continued for a maximum of 5 weeks. in each patient 10 ml peripheral blood will be drawn (t=0, t=24 hr, t=1 week, t=3-4 weeks (prior to the 2nd aminobisphosphonate administration). in addition, patients will be requested to measure their temperature thrice daily during the 2 days following the first aminobisphosponate administration. this, because a relation between the occurrence of a febrile response upon aminobisphosponate administration and an activation and expansion of vy9vd2-t cells has been suggested. peripheral blood mononuclear cells will be isolated from the drawn peripheral blood. using intra- and extracellular flowcytometry vy9vd2-t cells will be characterized phenotypically (apc markers: cd1d, cd40, cd80, cd83, cd86, hla-dr; activation/memory markers: cd25, cd27, cd45ra, cd45ro, ccr7) and functionally (ifn-γ, tnf-α, granzyme b). in addition, the frequency of cd3+, cd4+, cd8+ t cells, nk cells, b cells, inkt cells, cd4+cd25+ regulatory t cells, and circulating dendritic cells will be assessed.

Eligibility criteria:
inclusion criteria: * patients with an indication for intravenous treatment with an aminobiphosphonate because of a malignant tumor * who 0,1,2 performance score exclusion criteria: * who 3, 4 performance score * prior or current use of aminobisphosphonates -immunosuppressive medication (nsaid allowed) * chemotherapy and/or radiotherapy in 4 weeks prior to start of aminobisphosphonate administration * renal insufficiency (creatinine clearance \< 30 ml/min) * liver enzyme abnormalities: * bilirubin \> 1.5 times uln (upper limit of normal) * asat or alat \> 2.5 times uln (in absence of liver metastases) * asat or alat \> 5 times uln (in presence of liver metastases) * concomitant use of strong inhibitors of cyp3a4, such as itraconazole, ketoconazole, erytromycin, clarithromycin, hiv-protease inhibitors or grapefruit juice is contra-indicated.
profile of pain and unpleasant sensations in patients with referred pain

Conditions: Referred Pain; Somatic Pain; Neuropathic Pain

Summary: this feasibility study primarily aimed to assess the technology acceptance and usability of a pain tracking software in patients with spinally referred chronic pain. the secondary aim was to assess the fluctuations in pain intensity and distribution, using the pain tracking software during a 3-month period. additionally, the study aimed to explore the patients' behavior when self-reporting pain when given the opportunity to use a variety of pain quality descriptors, such as tingling, burning and stabbing. patients with spinally referred chronic pain will be recruited to participate. participants will be asked to use a pain tracking software to create weekly pain reports for a 3-month period. these pain reports consist of pain drawings and intensity scales. additionally, patients will complete baseline disability and pain catastrophizing online questionnaires. the project does not affect treatment or does not offer any intervention.


Eligibility criteria:
inclusion criteria: * suffer from pain in the neck or lumbar spine referring to a limb for a more than 7 consecutive days * participant is willing and able to give informed consent for participation in the study. exclusion criteria: * pregnancy or breastfeeding, severe infections, cancer. * epilepsy, multiple sclerosis, history of stroke, diabetes, traumatic spinal cord injury resulting in permanent functions loss * lack of ability to cooperate due to language barrier, cognition or inability to use technology.

Keywords: pain drawings referred pain somatic pain neuropathic pain e-health pain location biopsychosocial factors back pain neck pain pain extent function
acute effects of exercise on the cortical silent period in prostate cancer patients

Conditions: Prostate Cancer

Summary: in canadian men, prostate cancer (pca) is the most prevalent form of cancer and the third leading cause of cancer-related death. unfortunately, pca survivors are often burdened with feelings of anxiety and depression associated with the disease and associated treatments. short-term exercise interventions (8-24 weeks) have improved psychosocial well-being in this population, but the impact of single bouts of exercise and related psychological or neurological changes have never been studied. the primary objective of the proposed study is to examine the effect of an acute bout of exercise on neurophysiological and psychological indicators of well-being in a randomized controlled trial (rct) of 36 men with pca. participants will be randomly assigned to the intervention (60 min exercise) or control (60 min of television) and will undergo a brief neurological test (cortical silent period) and psychological questionnaires before and after their group assignment.


Eligibility criteria:
inclusion criteria: * histologically confirmed pca; * \> 6 months post curative therapy for pca (radical prostatectomy or radiation therapy) with or without adjuvant androgen deprivation therapy; * willing and able to provide informed consent; * if metastatic disease is present, they are asymptomatic; v) n * no contraindications to exercise exclusion criteria: * severe coronary artery disease (canadian cardiovascular society class iii or greater); * significant congestive heart failure (new york heart association class iii or greater); * uncontrolled pain; * neurological or musculoskeletal co-morbidity inhibiting exercise; * diagnosed psychotic, addictive, or major cognitive disorders or are currently or have a history of using psychotropic medication (anti-depressants, anti-anxiety, anti-psychotics, benzodiazepines, etc); * contraindications to magnetic exposure (surgical clips in the brain; cardiac pace maker or valves; cochlear implants; metal rods, plates, screws in head; shrapnel/metal fragments in head/eyes; dentures); * prior history of seizures or diagnosis of epilepsy; * left-hand dominant; and * no more than two of the following coronary risk factors as defined by the american college of sports medicine\[41, 42\]: * family history of coronary disease, cigarette smoking, hypertension (systolic blood pressure (sbp) \> 140 mmhg; diastolic blood pressure (dbp) \> 90 mmhg), known dyslipidemia, known impaired fasting, glucose (\>110 mg/dl), obesity (bmi \> 30 kg/m2 or waist circumference \> 102cm), or physically inactive (\<150 min of moderate intensity physical activity per week)

Keywords: prostate cancer exercise cortical inhibition cortical silent period transcranial magnetic stimulation
vascular endothelial growth factor levels in ectopic pregnancy

Conditions: Complication Following Ectopic Pregnancy

Summary: the aim of this study is to determine plasma vascular endothelial growth factor level and change in patient with ectopic pregnancy who needs to surgical treatment. patient with ectopic pregnancy diagnosed and treated with medically or surgically will be included in the study. this is an observational study.the plasma vascular endothelial growth factor level will be measured first day and two day after the diagnosis of ectopic pregnancy.

this study is a prospective, observational, single-center study. ethical approval was obtained from the institutional review board. this study will be completed with 30 patients with ectopic pregnancy. an intervenous cannula will be centrifuged for 15 minutes at 1000 g within 30 minutes of collection. aliquots of plasma will be added to eppendorf tubes and stored at -20°c. plasma vascular endothelial growth factor levels will be measured using a human vegf-a platinum elisa kit (bioscience company, catalog no: 00122, santa clara, california, usa). all assays will be performed according to the manufacturer's instructions. the test kit sensitivity is 2.5 pg/ml. intracycle variability is %4-6, intercycle variability is %8-10.

Eligibility criteria:
inclusion criteria: * patients who suspected ectopic pregnancy exclusion criteria: * hemodynamically unstable patient * healthy pregnancy (a healthy increase in ß hcg) * missed abortion * incomplete abortion * the patient who need immediate surgical treatment

Keywords: vegf, ectopic pregnancy.
pilot study evaluation of 2 artificial tears. evaluation of tbut, tear meniscus height and tear thickness

Conditions: Tear Film Thickness

Summary: to determine baseline tear thickness and improvement immediately post installation of two artificial tear solutions:(9582x) and allergan refresh tears.


Eligibility criteria:
inclusion criteria: 1. normal, healthy volunteers 18 years or older 2. males or females 3. any race or ethnic background exclusion criteria: 1. corneal refractive surgery within 6 months of this study. 2. contact lens use on day of examination. 3. corneal ectasia
comparing the safety and effectiveness of topiramate with the safety and effectiveness of amitriptyline in preventing migraine headaches

Conditions: Migraine; Headache

Summary: the purpose of this study is to compare the effectiveness and safety of two treatment regimens in preventing migraines. the antidepressant amitriptyline has been used successfully to prevent migraine headaches.

people who suffer from migraines have many prescription medications to choose from, both to treat the migraine and to prevent it from starting. however, many patients have not had success in finding the drug that helps them best. amitriptyline, an antidepressant, has been used successfully for many years to prevent migraine headaches. this study will compare the effectiveness of amitriptyline with the effectiveness of topiramate, an anti-seizure drug, in preventing migraines. the safety of both drugs will also be assessed. the objective of the study is to demonstrate that topiramate will be at least as effective as amitriptyline in preventing migraines. during the first 4 weeks of the study, topiramate or amitriptyline will be increased by 25 mg per week up to a total dose of 100 mg per day or up to the maximum tolerated dose, whichever is less. treatment will continue at 100 mg per day for 22 weeks.

Eligibility criteria:
inclusion criteria: * migraine headache for at least 6 months, with 3 to 12 headaches a month for the previous 3 months * no more than 15 headache days in the previous month before study start * no heart rhythm problems or neurologic problems * women must not be pregnant and must use birth control exclusion criteria: * cannot have failed at least 2 previous trials of migraine prevention drugs * cannot have failed a previous trial of topiramate or amitriptyline * no cluster headaches * no migraine with aura without headache * no pain that is worse than the migraine pain

Keywords: migraine headache analgesics prophylaxis prevention
forward head posture and hand function in dentists

Conditions: Forward Head Posture

Summary: this observational study investigates the correlation between forward head posture and hand grip strength, pinch grip strength, and wrist joint position sense among dentists aged 23-30 years. the aim is to understand the impact of poor head posture on upper limb function in dental professionals.

the study evaluates the relationship between craniovertebral angle and upper limb strength and proprioception using hand dynamometers, pinch gauges, and goniometers. forward head posture is assessed photometrically. a total of 82 participants will be recruited, all dentists, aged 23-30 years, with fhp confirmed by cva \<50°. hand grip, pinch grip (tip, palmar, lateral), and wrist joint position sense (flexion/extension) will be assessed in the dominant hand only.

Eligibility criteria:
inclusion criteria: * male and female dentists aged 23-30 bmi 18.5-29.9 kg/m² dominant hand used for testing forward head posture (cva \< 50°) exclusion criteria: * history of cervical trauma or surgery cervical radiculopathy or disc herniation upper limb neurological or orthopedic disorders dizziness, blurred vision, or neck/shoulder pain

Keywords: craniovertebral angle hand function posture assessment wrist proprioception
pilot trial to elaborate a cutaneous antigen neutralization test in patients suffering from rhinoconjunctivitis

Conditions: Allergy

Summary: to find a test to elaborate a parameter for specific immunotherapy in allergic patients


Eligibility criteria:
inclusion criteria: * age between 18 and 65 * signed informed consent * sit 2000/2001 * 10 patients with sit with a good result- 10 patients with bad results exclusion criteria: * pregnancy and breastfeeding
population-centered risk- and evidence-based dental inter-professional care team

Conditions: Dental Caries

Summary: the main goal of the payment and delivery system reform is to reduce disparities in oral health and dental care access of low-income mothers and children living in rural oregon counties. the target population is children, pregnant women and new mothers enrolled in oregon health plan (ohp) in rural oregon.

to implement a payment plan model based on global budgeting and alternative quality contract (pay-for-performance) for dental providers within advantage dental services, llc with the goal of incentivizing implementation of delivery system changes aimed at reducing disparities in access and oral health for low-income mothers and children living in rural oregon counties. to implement delivery system changes where a team of dental providers (dentists, dental hygienists, case managers, community outreach workers and others) within advantage dental services, llc provide evidence-based screening, risk assessment and primary preventive care in non-conventional community settings (wic, head start and similar settings) and seamless, timely and appropriate evidence-based care in advantage dental clinics. to evaluate and document the payment and delivery system changes to assess whether the changes result in (1) reductions in disparities in access for low-income mothers and children; (2) efficiency in allocation of limited resources with the application of evidence-based screening; (3) seamless and appropriate care for mothers and their child at high risk of dental caries

Eligibility criteria:
inclusion criteria: * children less than 21 years old and women who are pregnant or up to 2 months-post-partum. * enrollment in medicaid and assigned by oregon health authority to receive dental care from advantage dental plan. * home address is located in the selected counties. exclusion criteria: * none

Keywords: managed healthcare child dental care
emotion regulation dysfunctions in nssi adolescents in naturalistic contexts

Conditions: Nonsuicidal Self Injury; Emotion Regulation

Summary: nonsuicidal self-injury (nssi) is defined as direct, deliberate bodily harm without suicidal intention. recent studies indicate that prevalence rates are increasing worldwide, in particular under adolescents, indicating a growing public health issue. an impaired ability to regulate negative emotion has been suggested to play a potential role in nssi behavior. some recent interventions aim at improving dysfunctional emotion regulation via 'acceptance'. acceptance represents an objective, nonreactive, nonjudgmental, and calming emotion regulation strategy, partly based on the philosophy of dialectical behavior therapy (dbt) that has been widely used in the clinical treatment of nssi behaviors. the aim of the present functional magnetic resonance imaging (fmri) study is to examine whether adolescents with nssi can implement the acceptance strategy in naturalistic emotional contexts (immersive video clips) and whether they differ from healthy controls in terms of behavioral and neural effects. to this end, the investigators recruit one group of nssi adolescents (n=40) and one healthy control group (n=40), to compare the subjective emotional experience as well as underlying neural activity as measured by blood oxygenation level-dependent (bold) fmri. the investigators hypothesize that compared to hc, nssi adolescents will experience stronger negative emotions and show dysregulated neural recruitment of brain systems engaged in emotional reactivity and regulations (e.g. limbic regions, default mode network, and frontal regions).


Eligibility criteria:
inclusion criteria: * 15-18 years * right-handed * normal or corrected normal visual acuity * meet the proposed dsm-5 frequency criteria (e.g., ≥5 days of nssi behaviors in the past year) exclusion criteria: * diagnosis of borderline personality disorder, major depressive disorder, other psychiatric disorders, etc. * high suicidal risk * recent use of medications that can affect neural activity * have received or are receiving dialectical behavior therapy (dbt) other treatment for emotional problems within the past 6 months * have a contraindication to mri scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for mri scanning)