Kornimate/medical-research-clean huggingface dataset:
comparison of two different approaches in the surgical treatment of tubal ectopic pregnancy

Conditions: Ectopic Pregnancy

Summary: in this study we aim to compare conventional laparoscopy and natural orifice transluminal endoscopic surgery in the surgical treatment of ectopic pregnancy. all the patients, with an indication of surgery for ectopic pregnancy, will be asked to participate in this clinical trial. indication of surgery will be based on clinical findings, ultrasound scans and serum hcg levels. there will be no exclusion criteria. duration of surgery, successful completion of the operation, intraoperative data and postoperative data will be collected. all the patients will be asked to fill out quality of recovery-40 (qor-40) questionnaire and 36-item short form health survey (sf-36) before surgery. qor-40 questionnaire will be repeated 24 hours after surgery and repeated every 24 hours until discharge. sf-36 will be repeated at 1-month follow-up visit. patients will be also evaluated at postoperative 3-months, and female sexual function index will be asked to be filled-out.


Eligibility criteria:
inclusion criteria: * adults over 18 years of age, * diagnosis of tubal ectopic pregnancy * patient's preference to undergo salpingectomy exclusion criteria: * patients with contraindication to endoscopic surgery * refusal to sign informed consent.

Keywords: natural orifice transluminal endoscopic surgery laparoscopy ectopic pregnancy minimally invasive surgery quality of life sexual function
biofeedback intervention in rehabilitation of adolescence with posterior sagittal anorectoplasty

Conditions: Fecal Incontinence in Children

Summary: most of children undergo posterior sagittal anorectoplasty complain from faecal incontinence and faecal soiling which negatively impacts the social life of these children prohibiting their participation with their bears.

most of children undergo posterior sagittal anorectoplasty complain from faecal incontinence and faecal soiling which negatively impacts the social life of these children prohibiting their participation with their bears so this study aims prevent faecal incontinence so continue life time without any interference with social life and activities

Eligibility criteria:
inclusion criteria: * age from 10-13 years old * reliable females * able to understand verbal commands * normal vision and hearing exclusion criteria: * neuromuscular or musculoskeletal disorders * behavioural disorders * psychological disorders
neutrophil elastase and elafin as prognostic biomarker for acute respiratory distress syndrome

Conditions: Acute Respiratory Distress Syndrome, ARDS

Summary: the acute respiratory distress syndrome (ards), characterized by alveolar flooding with protein-rich pulmonary edema fluid, is one of the most common disease in the intensive care unit (icu) throughout the world. in recent years, much effort has been focused on the biological markers for their potential values to diagnose ards and outcomes. ards is generally accompanied by the disruption in alveolar-capillary barrier permeability, which subsequently caused an influx of neutrophils into the interstitium and alveolar space. it was reported that the aggregation, adhesion activation and release proteases of neutrophils are the key pathogenesis of ards pulmonary edema. neutrophil elastase (hne), the most crucial protease generated in neutrophil azurophilic granules, plays an important role in various inflammations, especially the lung injury. the destructive action of hne on almost all extracellular matrix influences cell signaling through cleavage of surface receptors. once released in circulation, hne is rapidly inactivated by conjugation with pi3. this local inhibitor reduces hne mediated tissue injury and inflammation. thus, the investigators plan to conduct a cohort study with repeated measures to examine the diagnostic and prognostic value of hne and pi3 for ards.


Eligibility criteria:
exclusion criteria: * age \<18 years * history of chronic lung diseases, such as interstitial pulmonary fibrosis or bronchiolitis * history of pneumonectomy * treatment with immunomodulating therapy other than corticosteroids, such as granulocyte colony stimulating factor, cyclophosphamide, cyclosporine, interferon, or tnf-α antagonists * presence of other immunodeficient conditions, such as hiv infection, leukemia, or neutropenia (absolute neutrophil count \<1000/μl) * history of organs or bone marrow transplant other than autologous bone marrow transplant * directive to withhold intubation * icu stay duration\<72h * patient developed ards before icu admission. sepsis and septic shock were defined according to the berlin definition
exercise in pregnant women with gestational diabetes

Conditions: Gestational Diabetes

Summary: gestational diabetes (gdm) impacts 1 in 10 pregnancies; hyperglycemia and hypertriglyceridemia are common features of the condition. women are recommended to do at least 150 minutes of moderate-intensity aerobic activity a week during pregnancy and the postpartum period. exercise both during and out of pregnancy has been shown to be an effective non-pharmacologic tool to reduce glucose and lipid profiles. the goals and purpose of this pilot study is to 1) determine the influence of exercise and the timing of exercise surrounding a meal on glucose and lipid metabolism in pregnant women with gdm and 2) determine the feasibility of low-resistance and aerobic activity and measuring exercise metrics during pregnancy. the overarching objective of this study is to determine the effects of low-resistance and aerobic exercise on glucose and lipids following a meal in pregnant women with gdm.

gestational diabetes (gdm) impacts 1 in 10 pregnancies; hyperglycemia and hypertriglyceridemia are common features of the condition. women are recommended to do at least 150 minutes of moderate-intensity aerobic activity a week during pregnancy and the postpartum period. exercise both during and out of pregnancy has been shown to be an effective non-pharmacologic tool to reduce glucose and lipid profiles. the goals and purpose of this pilot study is to 1) determine the influence of exercise and the timing of exercise surrounding a meal on glucose and lipid metabolism in pregnant women with gdm and 2) determine the feasibility of low-resistance and aerobic activity and measuring exercise metrics during pregnancy. the overarching objective of this study is to determine the effects of low-resistance and aerobic exercise on glucose and lipids following a meal in pregnant women with gdm. women will perform either low-resistance or aerobic exercise. blood will be taken before and 2 hours after a fixed meal. for safety, women will have supervised exercise and oxygen consumption will be measured throughout the activity.

Eligibility criteria:
inclusion criteria: * diet and lifestyle controlled gestational diabetes * gestational age 28 weeks-32 weeks gestation * age 18-50 years * singleton pregnancy exclusion criteria: * chronic hypertension * pregestational diabetes * history of peripartum cardiomyopathy * any condition contraindicating for exercise * taking any cardiovascular modifying medications (beta-blockers, calcium channel blockers, corticosteroids) * asthma or other underlying lung disease that is equivalent or worse than persistent mild classification (defined as at least \>2 day/week asthmatic symptoms, 1-2x/month nighttime awakenings, \>2days/week short-acting beta-agonist use for symptom control, and minor limitations with normal activity; ≥2 exacerbations in 6 months requiring oral systemic corticosteroids, ≥4 wheezing episodes/1 year lasting \>1 day) * congenital anomalies * multifetal gestation * current alcohol use * current tobacco use

Keywords: gestational diabetes pregnancy exercise
a randomized controlled trial of a conservative fluid balance strategy for patients with sepsis and cardiopulmonary dysfunction (balance study)

Conditions: Sepsis

Summary: sepsis is a common inflammatory response to infection characterized by hypovolemia and vasodilation for which early administration of intravenous fluids has been suggested to improve outcomes. the ideal fluid balance following initial resuscitation is unclear. septic patients treated in the intensive care unit commonly receive significant volumes of intravenous fluids with resultant positive fluid balance for up to a week after their initial resuscitation. observational studies have associated fluid receipt and positive fluid balance in patients with severe sepsis and septic shock with increased mortality but are inherently limited by indication bias. in order to determine the optimal approach to fluid management following resuscitation in patients with severe sepsis and septic shock, a randomized controlled trial is needed. the primary hypothesis of this study is that, compared to usual care, a conservative approach to fluid management after resuscitation in patients with sepsis and cardiopulmonary dysfunction will increase intensive care unit free days.


Eligibility criteria:
inclusion criteria: * icu patients * adults * sepsis as defined by at least two systemic inflammatory response syndrome criteria and receipt of antimicrobial therapy * cardiopulmonary dysfunction as defined shock or respiratory failure exclusion criteria: * inability to obtain consent * greater than 48 hours since inclusion criteria initially met * allergy to furosemide and bumetanide * rhabdomyolysis with creatinine kinase \> 5000 u/l * hypercalcemia with calcium \>11 mg/dl * diabetic ketoacidosis requiring continuous insulin infusion * tumor lysis syndrome diagnosed clinically * pancreatitis diagnosed clinically * chronic hypoxic respiratory failure with home oxygen use of fio2≥0.3 * chronic ventilator dependence * cervical spinal cord injury at level c5 or higher * amyotrophic lateral sclerosis * guillain-barré syndrome * myasthenia gravis * renal failure requiring renal replacement therapy * burns \>20% of body surface area * pregnant * preexisting pulmonary hypertension with papmean\>40 on rhc * severe chronic liver disease with childs-pugh score \>11 * moribund and not expected to survive an additional 24 hours * actively withdrawing life support or transitioning to comfort measures only * unwillingness of treating physician to employ conservative fluid strategy

Keywords: sepsis severe sepsis septic shock conservative fluid management fluid balance fluid restriction
effects of 12 weeks walking on cognitive function in schizophrenia

Conditions: Schizophrenia

Summary: this study is a 12-week randomized-controlled clinical trial. it will be planned to conduct in a total of 120 male and female subjects from the department of psychiatry at kaohsiung chang gung memorial hospital. eligible subjects will be psychiatric patients, aged between 20-65 years old, who have psychiatric diagnosis of schizophrenia and fulfill the inclusion and exclusion criteria. the intervention with aerobic walking programs will be initiated after randomization for patients who continue their usual treatment. subjects will be enrolled for 12 weeks aerobic walking treatment and randomly assigned to (1) treatment-as-usual, (2) treatment-as-usual plus aerobic walking. we will measure the treatment response to clarify the effect of aerobic walking in patients with schizophrenia. this study is being performed to investigate the possibly beneficial effects of aerobic walking on cognitive function and energy metabolites in schizophrenia.

this 12-week randomized-controlled clinical trial will be planned to conduct in a total of 120 male and female subjects from the department of psychiatry at kaohsiung chang gung memorial hospital. eligible subjects will be psychiatric patients, aged between 20-65 years old, who have psychiatric diagnosis of schizophrenia and fulfill the inclusion and exclusion criteria. the intervention with aerobic walking programs will be initiated after randomization for patients who continue their usual treatment. subjects will be enrolled for 12 weeks aerobic walking treatment and randomly assigned to (1) treatment-as-usual, (2) treatment-as-usual plus aerobic walking. the wearable watch will be used during the participants join the walking programs. we will measure the treatment response to investigate the effect of aerobic walking in patients with schizophrenia. this study is being performed to investigate the possibly beneficial effects of aerobic walking on cognitive function in schizophrenia.

Eligibility criteria:
inclusion criteria: 1. the patient has been diagnosed of schizophrenia according to the diagnostic and statistical manual of mental disorders, fifth edition criteria (dsm-5) criteria 2. the patient has the ability to complete the written informed consent exclusion criteria: 1. the patient has been diagnosed with organic mental disorders, intelligence disability, dementia, major depressive disorder, bipolar affective disorder, and alcohol or substance use disorder 2. the patient has major systemic physical diseases, including cardiovascular diseases, uncontrollable arrhythmia, renal diseases, liver diseases or thyroid diseases 3. the patient has certified as physical disability 4. the patient is pregnant or has genetic diseases or infectious conditions
prevention of contrast-induced nephropathy in diabetic patients with undergoing coronary angiography

Conditions: Contrast Induced Nephropathy

Summary: the aim of this study is to determine whether sodium bicarbonate is superior to sodium chloride in preventing contrast induced nephropathy in diabetic patients undergoing coronary angiography or intervention.

contrast induced nephropathy (cin) is a common cause of renal failure associated with prolonged hospitalization, significant morbidity or mortality, and cost. cin has been reported to account for 10% of hospital acquired renal failure. several strategies or medications were tried to prevent cin. of these, mucomyst and normal saline infusion are effective to prevent cin. sodium bicarbonate has shown mixed results from recent randomized trials. moreover,limited data have been available for preventing cin in diabetic renal dysfunction undergoing coronary angiography or intervention. our hypothesis is that addition of sodium bicarbonate will be more efficacious than normal saline in preventing cin at above situation.

Eligibility criteria:
inclusion criteria: * age\>18 years, no upper limits * diabetes treated with insulin or oral hypoglycemic agents * serum creatinine \>=1.1 and * resting estimated glomerular filtration rate \<60ml/min/1.73 square meter exclusion criteria: * serum creatinine \>=8mg/dl * resting estimated gfr \<15ml/min/1.73 square meter * end stage renal disease on hemodialysis * multiple myeloma * uncontrolled hypertension (systolic bp \>160mmhg or diastolic bp\>100mmhg) * acute myocardial infarction * emergent coronary angioplasty or angiography * recent use of contrast within 2 days * allergic reaction to contrast * pregnancy * allergic to following medication : theophylline, dopamine, mannitol, fenoldopam, n-acetylcysteine

Keywords: sodium bicarbonate diabetes mellitus coronary angiography or intervention
a health belief model based intervention to increase human papilloma virus (hpv) vaccination among college men

Conditions: HPV Vaccine Acceptability

Summary: the purposes of this study are to (1) identify predictors of human papillomavirus (hpv) vaccine acceptability among college men based on the health belief model through focus groups, (2) triangulate focus group results with a prior quantitative study in developing an intervention based on the health belief model to enhance hpv vaccine acceptability, and (3) test the efficacy of the above intervention based on the health belief model by comparing it to a knowledge-based intervention. approximately five focus groups with ten participants in each group with college students in the ages 18-25 years will be conducted at a large midwestern university for the qualitative piece. data will be analyzed for categories and triangulated with previous study to develop a theory based intervention. for the quantitative piece a randomized controlled design with 45 participants in each arm (theory based intervention and knowledge based intervention) will be implemented.

up to this date, there was a lack of qualitative research on vaccine acceptability among men and theory-based interventions that promote hpv vaccination among men. a few studies have been conducted with parents and physicians regarding hpv vaccination with girls, and a few regarding women's awareness and acceptability. results indicated increasing awareness of hpv, informing costs and benefits associated with the vaccine, and perceived susceptibility. based on this information, it is crucial to obtain a further understanding of knowledge, awareness, and predictors related to hpv and its vaccination in men. information obtained can be utilized in developing an intervention to increase intentions of taking the hpv vaccine. refining results will lead to a standardization of an intervention that can be implemented across college campuses.

Eligibility criteria:
inclusion criteria: * males * english speaking * 18-25 years * undergraduate or graduate student at the university of cincinnati exclusion criteria: * females * under 18 years, or above 25 years * non- english speaking individuals * non-university attending students * if already received hpv vaccination

Keywords: hpv college men hpv vaccine health belief model hpv vaccine acceptance
pain relief by intra-peritoneal nebulization of ropivacaine under remifentanil anesthesia for gynecological laparoscopy

Conditions: Gynecological Laparoscopy

Summary: in our prospective, randomized, placebo controlled and double-blinded study we will study the efficacy of intraperitoneal ropivacaine nebulization on pain relief during gynecologic laparoscopic surgery. this is a second steady with protocol of general anesthesia used of remifentanil.

outcome measures : * vas score * use of analgesics during operation and postoperative period

Eligibility criteria:
inclusion criteria: * elective gynecological laparoscopic surgery including unilateral or bilateral salpingo-oophorectomy or ovarian cystectomy * patient not participating in other medical study at present or during the last 30 days * patient is capable of reading, understanding and signing on an informed consent * age 18 years and above * asa physical status grade 1-2 exclusion criteria: * allergy to ropivacaine or other local anesthetics or other medications listed in the protocol * acute pelvic inflammatory disease * coumadin or aspirin treatment * significant arrythmias * analgesic treatment for chronic pain * bmi\>35
systemic chemotherapy versus transcatheter arterial chemoembolization(tace) for hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma

Summary: the purpose of this study is to determine that systemic chemotherapy is superior to transcatheter arterial chemoembolization in prolonging progression-free survival（pfs） in patients with advanced hepatocellular carcinoma.


Eligibility criteria:
inclusion criteria: * eligible patients were age 18 to 75 years; * the patients had histologically, cytologically,or clinically diagnosed unresectable hcc;and were ineligible for local invasive treatment. clinically diagnosed patients had to have: (1) evidence of hbv or hcv with hepatic cirrhosis; (2) a-fetoprotein levels 400g/l; and (3) morphologic evidence of hypervascular liver tumor. patients had to have at least one measurable lesion according to recist (version 1.0; ≥2 cm on computed tomography \[ct\]; 1 cm on spiral ct or magnetic resonance imaging). lesions that had undergone previous interventional or local therapy were not considered measurable lesions. * ecog score≤2; * life expectancy 3 months; * barcelona clinic liver cancer (bclc) stage b or c disease; * child-pugh stage a or b disease; * adequate organ and marrow function, with neutrophil count≥1.5x10e9/l, platelet count≥75×10e9/l, ast or alt﹤2.5×upper limit of normal (uln), total bilirubin \<1.5×uln, international normalized ratio \<1.5;normal baseline left ventricular ejection fraction_lower limit of normal for the institution. patients with ast and alt\<5 ×uln could be recruited if total bilirubin was in the normal range. * patients had to provide signed informed consent to participate. exclusion criteria: * documented allergy to lipoidal or other study drugs; any previous treatment before random assignment; * previous liver transplantation; * concomitant use of any other anticancer therapy, including interferon alfa and herbal medicine approved by the local authority to be used as anticancer medicine (except palliative radiotherapy to a nontarget lesion); * cns metastasis; * other serious illness or medical condition.
physiotherapy intervention for provoked vulvar vestibulodynia

Conditions: Vulvodynia; Provoked Vulvar Vestibulodynia

Summary: hypothesis: 1. specific physiotherapy interventions will decrease pain, improve pelvic floor motor control, increase self efficacy, improve sexual function and decrease pain catastrophizing behaviour in women with provoked vulvar vestibulodynia. this study will look at specific physiotherapy treatment interventions to see if they decrease pain, improve pelvic floor motor control, increase self efficacy, improve sexual function and decrease pain catastophizing behaviour. participants will fill out a questionnaire on their pain symptoms and complete standardized scales prior to starting treatment and after 4 sessions to determine change due to interventions. 2. a combination of physiotherapy, group educational sessions and group cognitive behavioural therapy will have better outcomes than physiotherapy alone. results of physiotherapy intervention alone will be compared to results of those treated with physiotherapy, group educational sessions and group cognitive behavioural therapy at a separate treatment centre. physiotherapy interventions and outcome measures are the same between both groups. justification: standard treatment is hard to identify as many approaches are taken, none with any evidence to support them. this study aims to look at specific techniques (pelvic floor coordination and relaxation exercises, education on female sexual response and pain pathophysiology education) to see if there is a benefit.


Eligibility criteria:
inclusion criteria: * 40 years and under * diagnosis of provoked vulvar vestibulodynia exclusion criteria: * early menopause * have had a total or partial hysterectomy * are on estrogen suppression medication * have a primary arousal disorder * declined admission to the multidisciplinary vulvodynia program at vancovuer general hospital

Keywords: provoked vulvar vestibulodynia vestibulitis
cohort study for the assessment of long-term impact of covid-19 among moderate and severe covid-19 patients in brazil

Conditions: COVID-19; Quality of Life; Disability Physical; Disabilities Mental

Summary: the present prospective cohort study aims to assess factors associated with of one-year health-related quality of life and physical, cognitive and mental health outcomes among adult survivors of hospitalization for covid-19. adult patients requiring hospitalization due to covid-19 disease will be followed through structured and centralized telephone interviews performed at 3, 6, 9 and 12 months after enrollment.


Eligibility criteria:
inclusion criteria: * age ≥18 years; * symptomatic covid-19 disease within the last 14 days; * positive polymerase chain reaction (pcr) test for sars-cov-2 within the last 14 days; * need of hospitalization (duration ≥ 48 hours). exclusion criteria: * severe comorbidity with life expectancy less than 3 months; * death during hospitalization; * absence of telephone contact; * absence of proxy for patients with communication difficulties; * refusal or withdrawal of agreement to participate; * previous enrollment in the study.