Kornimate/medical-research-clean huggingface dataset:
quality of life of patients with pregnancy related vte

Conditions: Health, Subjective

Summary: a retrospective study of the quality of life and problems experienced by patients who developed pregnancy related vte. it involves patients seen at juh in 2012-2020. a questionnaire will be filled by those patients and any other patients in jordan. it was translated to an arabic form from eq-5d, veines-qol/sym questionnaire and pemb-qol. the quality of their lives will be assessed and the problems encountered are going to be analyzed to try to find some solutions. this project is going to be a national research project with the efforts to try to find common platforms for those patients and nidus to establish a national support group.

retrospective study and analysis using a questionnaire which will be distributed to patients. the patients' data and contact details (phone numbers, whatsapp, email address...) will be collected from their clinical records at the juh hospital. the period 2012-2020 will be covered. the questionnaire link is; file:///c:/users/user/downloads/qol-post-vte-during-pregnancy-5.pdf and file:///c:/users/user/downloads/arabic%20questionnaire%20last%201.pdf

Eligibility criteria:
inclusion criteria: * pregnancy related event * confirmed diagnosis by an objective diagnostic tool (duplex ultrasonography, ct pulmonary angiography, spiral ct scan or ventilation perfusion scan) * consent (acceptance) to participate was obtained * alive patients exclusion criteria: * death * an objective diagnostic tool could not be found to confirm the diagnosis * their event was not related to pregnancy * refusal to participate
hippocampal neurogenesis in human subjects

Conditions: Hippocampal Neurogenesis in Cocaine Addiction

Summary: this study is being done to measure the number of brain cells that grow in the brain throughout our lives while determining an effective way to complete this with an mri (magnetic resonance imaging) scanner. the number of these brain cells may be affected by cocaine use. researchers are trying to understand the long-term effects of cocaine use on the brain.

new neurons are generated through the process of neurogenesis. although most active during pre-natal development, neurogenesis persists throughout the human lifespan. in adulthood, neurogenesis occurs predominantly in the subgranular zone of the hippocampal dentate gyrus. a highly novel methodology using magnetic resonance spectroscopy (mrs) has recently been developed to measure the formation of hippocampal newborn stem cells in the human brain. we propose to assess neural progenitor cells (npcs) in the neuropsychiatric disorder cocaine dependence, a chronic disease process associated with pathology of the hippocampus and impaired neurogenesis. in addition, we will assess other measures associated with neurogenesis, including hippocampal (dentate gyrus) cerebral blood volume (cbv) using vascular-space-occupancy (vaso) magnetic resonance imaging. we predict that newborn hippocampal cells \[or neuronal progenitor cells (npcs\] will be attenuated in recently using cocaine-addicted participants relative to abstinent and control participants, and that these changes will be paralleled by changes in cbv. in this pilot study, we will assess for these changes in cocaine-addicted subjects who are actively using cocaine and those who are recently abstinent (three to six months) as well as age-, race-, and gender-similar control participants.

Eligibility criteria:
inclusion criteria: * cocaine-dependence (patient population) or no cocaine-dependence (control population) exclusion criteria: * other medical or psychiatric disorders that may effect neural functioning * medications that may effect neural functioning

Keywords: neurogenesis addiction cocaine mri mrs
capsule biopsy in acellular dermal matrix-based prosthetic breast reconstruction: a prospective pilot study

Conditions: Breast Neoplasms; Mammaplasty; Acellular Dermis

Summary: in this prospective study, breast capsule biopsy was performed in patients undergoing 2-stage expander-implant breast reconstruction to determine its use. prospective clinical trial was designed for 10 consecutive patients as a pilot study and approved by irb of samsung medical center. from november 2013 to may 2015, full-thickness capsule biopsy specimen was obtained from acellular dermal matrix (adm) capsule and from native subpectoral capsule (internal control) during expander-implant exchange. biopsy specimens were scored for fibrosis and inflammatory reactions. this is completed study and its specific title, study objective, method, and results will be available online after scientific journal submission.


Eligibility criteria:
inclusion criteria: * age between 20 and 70 * planning 2-stage expander-implant breast reconstruction using acellular dermal matrix * with no medical history such as diabetes, hypertension, or smoking * no surgical history exclusion criteria: * pregnant * newly detected medical or surgical condition * acellular dermal matrix loss due to allergic reaction or prosthetic infection * breast cancer recurrence * transfer to other institution * reconstruction give-up due to patient's wish * no biopsy score
exercise training in obesity-prone black and white women

Conditions: Obesity

Summary: overweight premenopausal black and white women are randomized to either diet-only, diet+aerobic or diet+resistance exercise training. diet/behavior intervention, with or without the aerobic or resistance exercise training, will be provided throughout the 18 months of study. major outcomes will include measures of perceived and physiologic difficulty of exercise (cardiac, ventilatory, electromyographic responses to standardized exercise tasks); aerobic fitness; strength fitness; and spontaneous free-living energy expenditure (all derived from doubly labeled water). the results will provide insight into the effectiveness of, and the mechanisms by which, different types of exercise training can improve physical fitness, spontaneous engagement in physical activities of daily living and, in turn, weight-loss maintenance.

overweight premenopausal black and white women are randomized to either diet-only, diet+aerobic or diet+resistance exercise training. diet/behavior intervention, with or without the aerobic or resistance exercise training, will be provided throughout the 18 months of study. major outcomes will include measures of perceived and physiologic difficulty of exercise (cardiac, ventilatory, electromyographic responses to standardized exercise tasks); aerobic fitness; strength fitness; and spontaneous free-living energy expenditure (all derived from doubly labeled water). the results will provide insight into the effectiveness of, and the mechanisms by which, different types of exercise training can improve physical fitness, spontaneous engagement in physical activities of daily living and, in turn, weight-loss maintenance. time of initial weight loss was defined as the time needed to reach the goal of 25 kg/m2 bmi. the women will then be evaluated one year after this time and the amount of weight gain will be determined.

Eligibility criteria:
* normoglycemic * bmi between 27-30 * non smoker * premenopausal * physically untrained * family history of obesity
effect of snapshot freeze on cardiac ct image quality

Conditions: Heart Diseases

Summary: the aim of this study was to investigate the effect of a new motion correction algorithm on image quality and diagnostic utility in unselected patients undergoing coronary cardiac computed tomography, and to investigate if this motion correction algorithm can compensate for the usual use of intravenously medication (beta-blockers) before the scan.

aims: to investigate the motion correction algorithm snapshot-freeze(ssf) compared to standard reconstruction(std) in patients randomized to receive beta-blockers(bb) or no beta-blockers(non-bb) before coronary ct angiography (ccta), and to investigate if ssf can replace bb. methods: the study included 140 consecutively recruited patients scheduled to ccta to rule out coronary artery disease. the inclusion criteria were: age ≥ 18 years, glomerular filtration rate ≥ 60 ml/min, heart rate between 60 and 85 bpm before the scan. the exclusion criteria were: irregular heart rhythm or history of allergic reaction to contrast agents. patients were randomized to the bb group or the non-bb group. the trial complied with the declaration of helsinki and was approved by the local ethics committee. written informed consent was obtained from all patients. image quality score: the evaluation was performed according to the likert score as follows: 1: excellent, no motion artifacts, clear delineation of the segments; 2: good, minor artifacts, mild blurring of the segment; 3: adequate, moderate artifacts, moderate blurring without structure discontinuity; and 4: poor and non-diagnostic, with doubling or discontinuity in the course of the segments, preventing evaluation or producing vessel structures that were not differentiable. in cases where the image quality was less than excellent (likert score 2-4), the readers noted the reason(s) for the observed artifact. statistical analyses: quantitative variables were expressed as mean ± standard deviation, and categorical values as frequencies or percentages. values from the likert score were dichotomized to excellent vs. non-excellent (likert score 1 vs. 2-4), and diagnostic vs. non-diagnostic (likert score 1-3 vs. 4). mcnemar's test was performed to test categorical variables separately per-vessel and per-patient level. analyses for all segments were calculated by the wilcoxon signed-rank test.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years, * glomerular filtration rate ≥ 60 ml/min, * heart rate between 60 and 85 bpm before the scan exclusion criteria: * irregular heart rhythm * history of allergic reaction to contrast agents

Keywords: coronary computed tomography angiography motion artifacts motion correction algorithm diagnostic utility
modeling multi-level dyadic behavior to transform the science and practice of psychotherapy process and outcome.

Conditions: Major Depressive Disorder

Summary: this is a short-term longitudinal study of psychotherapy process. participants will be treated with 8 sessions of psychotherapy over the course of 8 to 12 weeks.

enrolled participants were randomized to one of two psychotherapy conditions: 8 sessions of brief cognitive behavior therapy or brief interpersonal psychotherapy (ipt) over a 12 week protocol. in response to the covid-19 pandemic, we completed the study in two phases. phase 1 procedures were conducted entirely in-person and phase 2 procedures were conducted via telehealth. phase 1 recruitment began july 2018 and concluded in february 2020. recruitment for phase 2 began july 2020 and concluded march 2021. this project aims to model the dynamics of individual and dyadic behavior on a moment-by-moment basis within each therapy session and over the course of treatment. these models will be used to test hypotheses about multimodal behavior dynamics, psychotherapy process, type of treatment, and treatment outcome.

Eligibility criteria:
inclusion criteria: 1. age 18-65 2. meet dsm-5 criteria for major depressive disorder (mdd), current episode, based on the mini international neuropsychiatric interview (mini) 3. hamilton rating scale for depression (hrsd-17) score ≥ 14 consistent with at least moderate depressive symptoms 4. if currently on antidepressant medication, must be on a stable dose for at least one month at the time of study entry and agree to remain on that dose for study duration 5. fluent in english 6. capacity to understand and give informed consent exclusion criteria: 1. at high risk for suicide, that, in the clinical opinion of the investigator, would warrant a higher level of care such as hospitalization or intensive outpatient programs 2. current depressive episode has psychotic features 3. current depressive episode has been present for \> 104 weeks 4. meets criteria for substance use disorders, as defined by dsm-5, in the past 3 months, except for caffeine or nicotine. (limited substance use, not meeting criteria for substance use disorders, is not exclusionary). 5. meets dsm-5 criteria for prior manic or hypomanic episode (bipolar i or ii disorder) or a psychotic disorder including schizoaffective disorder or schizophrenia 6. meets dsm-5 criteria for antisocial personality disorder (mini) 7. significant, unstable, psychiatric co-morbidity that, in the opinion of the investigators, requires an alternative treatment approach (i.e., unstable eating disorder, unstable borderline personality disorder) 8. significant unstable medical illness that may explain depressive symptoms such as epilepsy, autoimmune disorder, chronic pain, or unstable endocrine disorder 9. cognitive deficits that would preclude completion of study questionnaires or participation in psychotherapy 10. unable to unwilling to comply with study requirements (i.e., complete forms, attend sessions)
long-term impact of inhaled tobramycin for pseudomonas aeruginosa eradication in bronchiectasis (erase ii)

Conditions: Bronchiectasis Adult

Summary: the erase ii study is a prospective follow-up study designed to assess the long-term impact of successful eradication of pseudomonas aeruginosa (pa) in patients with bronchiectasis. building on the findings of the initial erase study, which evaluated the efficacy and safety of tobramycin inhalation solution, erase ii aims to determine whether successful pa eradication influences patient prognosis over an extended period. the study will involve a total observation period of 36 months, consisting of the initial 9 months of the erase study followed by an additional 27 months of comprehensive follow-up. key outcomes to be assessed include patients' quality of life, lung function, frequency of pulmonary exacerbations, frequency of hospitalization, and overall treatment costs. additionally, the study will examine the timing and incidence of any potential reinfections with pseudomonas aeruginosa.

individuals with bronchiectasis are particularly susceptible to infections from pseudomonas aeruginosa (pa), which can become chronic and lead to increased mortality and disease severity. to address this critical issue, we have designed a multi-center, 2×2 factorial randomized, double-blind, placebo-controlled trial known as the erase study. this trial aims to evaluate the efficacy and safety of tobramycin inhalation solution in the eradication of pseudomonas aeruginosa in bronchiectasis patients with newly or firstly isolated pa. building upon the findings of the erase study, the erase ii study seeks to investigate whether successful eradication of pa influences the long-term prognosis of patients after the completion of the randomized controlled trial. to achieve this, we plan to extend the observation period to a total of 36 months, comprising the initial 9 months of the erase study, followed by an additional 27 months of comprehensive follow-up. this extended observation period will enable us to assess the long-term impact of eradication therapy on various clinical outcomes, including patients' quality of life, lung function, frequency of pulmonary exacerbations, frequency of hospitalization, and overall economic treatment costs. additionally, we will evaluate the timing of any potential reinfections/relapse with pseudomonas aeruginosa, thereby providing valuable insights into the long-term benefits of eradication strategies in patients with bronchiectasis.

Eligibility criteria:
inclusion criteria: * all patients who participate the erse study * write the informed consent form. exclusion criteria: * patients who were lost of follow up in the erase study * ineligible for inclusion at the discretion of the researcher for other reasons.

Keywords: bronchiectasis pseudomonas aeruginosa eradication long-term impact observational study
outcomes of autologous bone marrow-derived mononuclear cell transplantation in the management of neurological sequelae

Conditions: Sequelae of Injuries of Head

Summary: the purpose of this study is to evaluate the safety and efficacy of autologous bone marrow-derived mononuclear cell transplantation in the management of neurological sequelae after traumatic brain injury

to evaluate the safety and efficacy of autologous bone marrow-derived mononuclear cell transplantation in 25 patients with neurological sequelae after traumatic brain injury compared with 25 patients in control group (no intervention) at the time points of baseline, 3rd month (d90), 6th month (d180), and 12th month (d360).

Eligibility criteria:
inclusion criteria: * age: from 20 to 50 years * gender: either sex * duration after brain trauma: 6 - 12 months * functional independence measure - fim \< 69 * closed head injury exclusion criteria: * neurologic impairment or neurological disease before the time of the accident. * active infections * tumours or failure of heart, lung, liver or kidney, respiratory distress syndrome * anaemia, clotting disorder * cancer * pregnancy * alcoholic * patient was unemployed or did not attend school before the accident. * severe injuries: spinal cord injury, pelvic inflammation, cardiopulmonary

Keywords: traumatic brain injury mononuclear cell neurological sequelae
effects of imaginary resisted exercise versus physical resisted exercise on hand grip strength in stroke patients

Conditions: Stroke

Summary: the goal of our study is to make a comparison between the effectiveness of physical resistance exercise and imaginary resistance exercise in improving handgrip strength, dexterity, and eye-hand coordination among stroke patients.

a randomized control trial study will be conducted in which patients with stroke will be allocated to group a that will receive imaginary resistance exercises and patients in group b will receive physical resistance exercises. the intervention will be applied (3 days /week) for 12 weeks, which consists of 5 different types of resistance using 5 different resistive objects, each will have 15 repetitions. each session includes handgrip exercises with physical resistance exercises for one group and imaginary resistance exercises using virtual reality box for another group. as for improving dexterity and eye-hand coordination, the purdue pegboard test and finger-to-nose test will be used respectively in both groups with 15-15 repetitions.

Eligibility criteria:
inclusion criteria: * age should be in the range from 50 years to 75 years * time passed since stroke attack should be more than one year. * grade of manual muscles testing for elbow and wrist, flexion / extension should be more than 2 out of 5. * scoring of modified ashworth scale should be more than 3 out of 5 for the same muscle groups of previously mentioned movements. exclusion criteria: * any significant pain present in the affected upper limb. * increased muscle tone that interferes with movements of the affected upper limb. * serious sensory loss in the affected upper limb. * severe medical issues currently. * cognitive impairment to a level that interferes with sessions of intervention. * impairments of vision that disables patient to perform interventional exercises. * serious presence of apraxia / neglect. * if enrolled for any related or alike other upper limb therapy sessions / interventional studies.

Keywords: stroke physical resisted exercise imaginary resisted exercise hand grip strength
seven year update of macular degeneration patients

Conditions: Age-related Macular Degeneration

Summary: the purpose is to assess long term vision outcomes and disease status in patients with age-related macular degeneration previously treated with ranibizumab as participants in the phase 3 anchor and marina studies and the horizon study.

this is a cross-sectional cohort study of exudative age-related macular degeneration (amd) patients seven or more years after initiation of the intravitreal ranibizumab regimen in the treatment arms of the pivotal anchor or marina studies, who had subsequent follow up in the horizon study. while the marina and anchor studies established the benefit of ranibizumab at 2 years, many patients in the u.s. have now undergone treatment for many years, and the longer-term outcomes for this chronic disease remain unknown. despite earlier hopes for limited duration treatment, subsequent clinical experience suggests that many patients require continued treatment. the patient population for this study is unique, in that the patients in the treatment arms of marina and anchor are some of the earliest treated patients, providing the longest-term data available for amd patients receiving ranibizumab. patients recalled into this study will be evaluated to provide an update on their current visual acuity, disease activity status, anatomic characteristics, and genotype. there is a single study visit to extend the clinical history and to perform vision testing, ophthalmologic examination, and retinal imaging studies, including high-resolution spectral-domain oct and fundus autofluorescence imaging, technologies unavailable at the time of the original anchor and marina trials. genetic analysis will be performed for known amd risk genes as well as candidate genes to study genotypic profiles associated with amd disease progression and long-term treatment response. understanding the course of 7-plus years of current generation amd treatment will serve physicians in the ongoing management of this chronic disease.

Eligibility criteria:
inclusion criteria: * previous participants in the anchor or marina studies, and... * who were assigned to one of the ranibizumab treatment arms, and... * who were enrolled in the horizon extension study with a current seven up investigator * ability to provide written informed consent and comply with study assessments exclusion criteria: * any separate ophthalmologic condition that the investigator believes would interfere with anatomic assessments in the trial

Keywords: age-related macular degeneration ranibizumab geographic atrophy anchor study marina study
comparison of visual instructions for inserting a laryngeal mask in a neonatal mannequin.

Conditions: Cardiopulmonary Resuscitation; Newborn Asphyxia

Summary: this research project compares the effectiveness of two visual instructions for inserting laryngeal masks. researchers will assess the procedure performed by undergraduate health students on neonatal mannequins. the student's performance will be evaluated by assessing the results, timing and sequence recorded in videos during the simulation. an ethical committee reviewed and approved the protocol.

this research project compares the effectiveness of two visual instructions for inserting laryngeal masks. researchers will assess the procedure performed by undergraduate health students on neonatal mannequins. the students will participate voluntarily after signing an informed consent. the participating students will be randomly assigned to one of the two groups, each receiving a different visual instruction. the student's performance will be evaluated by assessing the results, timing and sequence recorded in videos during the simulation. an ethical committee reviewed and approved the protocol. the universidad nacional mayor de san marcos funded the investigation through the 2024 grant contest for research groups. the project aims to provide evidence of the advantages of visual instructional methods for inserting laryngeal masks, which contribute to advancing knowledge in medical training and neonatal procedures. the results are expected to inform the selection of more effective educational materials, thus improving student preparation and neonatal care. this research has the potential to bridge the gap between academic theory and clinical practice, benefiting both society and scientific development in neonatal medicine.

Eligibility criteria:
inclusion criteria: * students, health occupations * in the last year of studies at the university of san marcos or any other similar university, and having basic knowledge of neonatal procedures. exclusion criteria: * student not registered or withdrawn from courses * not having signed the informed consent