Kornimate/medical-research-clean huggingface dataset:
moda-flx hemodialysis system™ under professional care settings by trained individuals and at home by participants

Conditions: End Stage Kidney Disease

Summary: the purpose of this study is to evaluate the safety and efficacy of the moda-flx hemodialysis system™ when used under professional care settings by trained individuals and at home by trained participants and care partners


Eligibility criteria:
inclusion criteria: * are between 18 and 75 years of age and care partner is at least 18 years of age at the time of signing consent * have a diagnosis of end stage kidney disease (eskd) adequately treated by maintenance dialysis (defined as achieving a spkt/v ≥ 1.2 or stdkt/v ≥ 2.1) and be deemed stable by their treating nephrologist prior to the end of the run-in period * in the opinion of the investigator, have a well-functioning and stable vascular access (tunneled central venous catheter arteriovenous fistula, or graft) that allows a blood flow of at least 300 ml/min prior to the end of the run-in period * in the opinion of the investigator, can successfully complete a skills assessment with a care partner prior to the completion of the training period exclusion criteria: * hgb level of \< 9 g/dl at screening * symptomatic intradialytic hypotension requiring medical intervention (ultrafiltration turned off, bolus of fluid) in at least two treatments during the run-in period defined as: 1. persistent pre-dialysis sitting sbp \< 100 mmhg despite medical therapy, 2. nadir intradialytic systolic blood pressure (sbp) \< 90 mmhg, if subject's pre-hd sbp \< 160 mmhg 3. nadir intradialytic sbp \< 100 mmhg if subject's pre-hd sbp ≥ 160 mmhg * documented history of non-adherence to dialysis therapy that would prevent successful completion of the study

Keywords: renal disease hemodialysis complication kidney diseases dialysis renal dialysis hemodialysis, home renal insufficiency kidney failure, chronic
radiomics of hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma

Summary: we propose a radiomics approach to identify prognostic biomarkers of hcc and provide patients with some reasonable advice for their therapies.

radiomics is emerging fields that is based on quantitative analysis of medical images. tri-phasic ct images are currently the standard imaging modality for the management of hcc. our goal is to improve treatment decisions of hcc patients through better understanding of their prognosis based on radiomics modeling of hcc. radiomics is defined as the extraction of quantitative image features from medical images. we will use triphasic ct data of at least 200 patients and develop a robust strategy to extract imaging features from ct. we will use deep learning in the form of a convolutional neural network to segment hcc lesions and use image feature extraction algorithms with supervised classification to predict prognosis.

Eligibility criteria:
inclusion criteria: * the purpuse of our research is to improve treatment ,therefore we have no creteria. exclusion criteria: -

Keywords: radiomics prognosis medical images hepatocellular carcinoma
guided tissue regeneration with a periodontal dressing

Conditions: Periodontal Diseases

Summary: this randomized, controlled split-mouth study will include 24-40 patients. after gtr, a test and a control side will be selected by means of a computer-generated randomization list. test sides will receive a periodontal dressing (coepak") for 14 days and the control sides will receive no periodontal dressing. after 14 days the periodontal dressing will be removed and the pain experience will be recorded. after 6-9 months, the clinical periodontal parameters will be recorded.


Eligibility criteria:
inclusion criteria: * age between 18 and 75 years. * a minimum of 18 teeth, wisdom teeth excluded. * previously untreated moderate chronic periodontitis (armitage 1999) with radiographic evidence of generalized alveolar bone loss \>30%. * presence of at least one pocket with probing pocket depth (ppd) ≥6 mm per quadrant, which was bop. * presence of at least three teeth per quadrant. exclusion criteria: * periodontal treatment in the last 3 years. * antibiotic intake 6 months before • the screening visit. * pregnancy. systemic diseases with an impact on periodontal healing (e.g. dia- betes).
the effect of anesthesia on systemic inflammatory immune index in major abdominal cancer surgeries

Conditions: Systemic Immune Activation; Cancer Gi; Cancer of Endometrium

Summary: the effects of different anesthesia methods on the immune system are variable. in this study, we investigated the effect of inhalation anesthesia and total intravenous anesthesia on the sii value in major abdominal cancer surgeries.

the study was planned prospectively, observationally, on a total of 90 patients who underwent major abdominal cancer surgery. 84 patients were evaluated. the patients were seperated in two groups as inhalation anesthesia and total intravenous anesthesia (tiva). the demographic data of the patients, type of cancer, type of surgery performed, asa classification, preoperative chemotherapy intake, preoperative hemogram, postoperative 2nd and 24th hour hemogram, intraoperative and postoperative blood transfusion, and duration of surgery were recorded. platelet, neutrophil, lymphocyte and sii values were saved.

Eligibility criteria:
inclusion criteria: * major abdominal cancer surgeries exclusion criteria: * blood transfusion in last 72 hours * patients with infection * hematologic malignancy * patient controlled analgesia
comparison of interventions in patients with carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome; Carpal Tunnel Syndrome Bilateral

Summary: this study aims to compare two types of intervention (stretching and myofascial manipulation) in the treatment of individuals with bilateral idiopathic carpal tunnel syndrome. this comparison applies to two groups, the clinical group is composed of patients of mild or moderate degree, whereas the surgical group is composed of a patient with at least one hand in severe degree and interventions are made after surgery.

using clinical criteria and enmg, individuals will be divided into a clinical group when they have a mild and / or moderate degree of involvement in the hands and a surgical group when the impairment intensity is severe in at least one hand. the individuals in the clinical group will be randomized into two groups, with one group starting with stretching and a second group starting with hook-assisted myofascial manipulation. after four weeks of initial therapy and one week of wash-out the assessment tests described above will be applied. the groups will be inverted, maintaining the duration and frequency of the previous stage of the proposed therapies. after four weeks with a week of wash-out the tests will be reapplied in order to evaluate the therapeutic response. individuals with severe idiopathic cts will undergo surgery using a standard open technique with local anesthesia and after four weeks, randomization will be made for postoperative treatment on both hands by stretching or myofascial manipulation in the same manner described for the clinical group. questionnaires will be applied in order to understand the patient's symptoms, functions, pain and quality of life. in addition, tests will be used to assess hand strength, sensitivity and hand ability.

Eligibility criteria:
inclusion criteria: * bilateral idiopathic cts above six months of symptomatology; * with clinical criteria and enmg for indication of clinical or surgical treatment; * who have no history of gabapentin allergy. exclusion criteria: * individuals with cts for other reasons, such as pregnancy, arthritis, hypothyroidism, diabetes mellitus, trauma, expansive tunnel damage, amyloids, sarcoidosis, multiple myeloma, and leukemia. * individuals with conditions that can simulate cts, such as carpometacarpal thumb arthritis, cervical radiculopathy mainly of the sixth cervical root level, radial flexor carpal tenosynovitis and central disorders such as multiple sclerosis and cerebral infarction.
frailty in liver transplant exercise (flex) trial

Conditions: Frailty; Liver Transplants

Summary: frailty is common in patients with end-stage liver disease. it's characterized by reduced strength, low endurance and reduced physical function. while exercise intervention can improve frailty in geriatric patients without liver disease, whether or not exercise intervention can improve frailty in liver transplant candidates remains unknown.

the long-term goal is to better understand how exercise impacts frailty in order to identify treatments that can improve both patient-oriented outcomes and access to liver transplantation for end-stage liver disease patients. the specific objective of this proposal is to generate pilot feasibility data required for future multicenter r01 application to the national institute of diabetes and digestive and kidney diseases (niddk) which will test the novel central hypothesis that exercise improves frailty and lessens waiting-list mortality. additionally, another goal of the study is to establish an optimal frailty tool for liver transplant candidates.

Eligibility criteria:
inclusion criteria: * adults age ≥18 or ≤75 years * frail as defined by a lfi score of \>4.5 * under evaluation or listed for liver transplant exclusion criteria: * active cardiac symptoms (e.g., chest pain, shortness of breath at rest, palpitations) * positive response to get active questionnaire (gaq) (validated activity questionnaire that indicates if exercise is unsafe) * institutionalized/prisoner * severe medical comorbidities/psychiatric illness at the discretion of the study principal investigator (pi)
genomic study of genetic polymorphisms involved in immediate allergic reactions to beta-lactam antibiotics

Conditions: Beta-Lactams Allergy; Hypersensitivity

Summary: beta-lactam antibiotics include penicillin and cephalosporins and are among the most prescribed antibiotics. this category of drugs is the most involved in immediate allergic manifestations with 2% reactions in treated subjects and a fatal outcome in 1/50000 treatments. reactions are ige-mediated and have a considerable but unknown genetic origin, revealed by studies in groups of different ethnical origins in the same geographical region. there are also some families with a high frequency of allergic reactions without identified mendelian inheritance. the purpose of this study is to identify predictive risk factors associated to immediate allergic reactions against beta-lactam antibiotics with a pangenomic approach. a secondary purpose is to identify rare predictive factors with homozygosity mapping and exome sequencing in various families with high risk of allergy to beta-lactam antibiotics.


Eligibility criteria:
inclusion criteria: * informed consent * allergy group: immediate allergic reaction (less than 2 hours after drug administration) to an antibiotic of penicillin or cephalosporin groups * allergy group: positive skin test (intradermal test) with a non-irritant dilution of antibiotic of penicillin or cephalosporin groups exclusion criteria: * refusal of participation
calciphylaxis : population, risk factors, diagnostic practice, therapeutic and outcome

Conditions: Calciphylaxis

Summary: calciphylaxis, also called calcific uremic arteriolopathy (cua) is a lethal affection mostly affecting patient in end stage renal disease. the survival rate is described around 20 to 46% at one year. clinical presentation is very painful skin lesions with ulceration mostly located on the trunk or thigh. current knowledge about physiopathology, diagnostic practice and therapeutic is very limited. actually there is no european study about calciphylaxis and risk factors, diagnostic practice and outcome factors.


Eligibility criteria:
inclusion criteria: * patients ≥ 18 years with chronic renal failure with glomerular filtration rate \< 30ml/min/1,73m² * diagnosis of calciphylaxis between 2006 and 2016 * living in the regions of bretagne, pays de la loire, poitou-charentes or centre val de loire. exclusion criteria: * realized biopsy in favor of differential diagnosis * significant arterial lesion of lesion area or differential diagnosis more valid * if the diagnosis is not based on the following criteria: 3 clinical criteria or 2 clinical criteria and biopsy in favor, criteria which are : * patient in chronic hemodialysis or stade 4 chronic kidney disease * at least 2 painful sores and hardly curable with concomitant painful purpura * sore and purpura localisation in trunk, extremities and penis.

Keywords: calcific uremic arteriolopathy case-control study cohort study
gene expression in samples from patients with t-cell acute lymphoblastic leukemia

Conditions: Leukemia; Lymphoma

Summary: rationale: studying samples of blood and tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. it may also help doctors find better ways to treat cancer. purpose: this research trial studies gene expression in samples from patients with t-cell acute lymphoblastic leukemia.

objectives: * to test whether the tumor suppressor candidate gene pdlim2 is downregulated in human cancers such as t-cell acute lymphoblastic leukemia (t-all) and to use the human t-lymphotropic virus 1 (htlv-1)-mediated in vitro transformation of human t cells as control. outline: previously collected cancer and control tissues are analyzed for the expression patterns of pdlim2 and other control genes. human t-cells isolated from human blood are also co-cultured with htlv-1-transformed t-cell lines.

Eligibility criteria:
disease characteristics: * specimens (e.g., tissue, blood, and bodily fluids) of various cancer cells and or tissues from de-identified patients such as t-cell acute lymphoblastic leukemia (t-all) * normal control tissue patient characteristics: * not specified prior concurrent therapy: * not specified

Keywords: adult acute lymphoblastic leukemia childhood acute lymphoblastic leukemia adult t-cell leukemia/lymphoma
the foundation study

Conditions: Preterm Infant

Summary: the foundation study will evaluate the tolerability of feeding preterm infants a b. infantis probiotic (evc001) as the primary endpoint. this particular strain of bifidobacterium has been shown to uniquely utilize oligosaccharides found in human breast milk, possibly providing a nutritional benefit for the infant consuming breast milk when b. infantis is colonized in the gut.

this is a single-center, open-label, prospective, cohort study of an infant probiotic (food for special dietary use) conducted in the neonatal intensive care unit (nicu). each subject enrolled will be in the study from the time of consent (within 10 days of birth) to hospital discharge. a prospective control cohort of 15 infants will initially be enrolled. fifteen (15) infants will then be enrolled into the b. infantis cohort. infants in the b. infantis cohort will receive a daily feeding of b. infantis evc001 in mct oil until hospital discharge.

Eligibility criteria:
inclusion criteria: 1. birth weight \< 1500 grams or gestational age at birth \< 33 and 0/7 weeks 2. ≤ 10 days of life and considered viable 3. consuming exclusive human milk diet (mother's milk or donor milk) with or without fortifier at time of enrollment 4. toleration of 1.0 ml bolus enteral feeds exclusion criteria: 1. presence of septicemia or active infection as determined by positive 48-hour blood cultures 2. necrotizing enterocolitis 3. pulmonary hypoplasia 4. presence of clinically significant congenital heart disease or other major congenital malformation 5. any infant the investigator deems to be ineligible for participation
exploratory study using a new head-only pet scanner

Conditions: Brain Diseases

Summary: the "bpet prototype" is a small aperture pet scanner. the bpet prototype will be used with patients, which have just finished their regularly scheduled pet examination on a clinical whole body pet system. the radioactive tracer used for this procedure will still be active. this remaining acitivity will be used for an image acquisition with the bpet prototype without the need for an additional radioactive tracer dose. the control intervention is be a brain pet scan as part of standard clinical routine. it will be done immediately before the scan on the bpet prototype.


Eligibility criteria:
inclusion criteria: * capable of giving informed consent as documented by signature (appendix informed consent form) * ability to sit still in the head-only pet scanner for 15 minutes * are scheduled to receive a regular brain pet scan as part of clinical routine. * male and female patients 18 years to 80 years of age exclusion criteria: * contraindications to pet examination, * patient height smaller than 160 cm or taller than 200 cm, * patient weight more than 120 kg, * patient cannot sit upright for at least 15 minutes, * metal implants in the head, * inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, severe dementia, etc. of the participant, * participation in another study with investigational drug/device within the 30 days preceding and during the present study, * previous enrolment into the current study, * enrolment of the investigator, his/her family members, employees and other dependent persons.
presence of minor anti phospholipid antibodies in blood samples of ischemic stroke patients and healthy controls

Conditions: Ischemic Stroke

Summary: the investigators expect to find higher levels of both classical and minor antiphospholipid (apl) antibodies among the stroke cases. furthermore, the investigators expect to find not only classical apla but also minor antibodies. the investigators believe that minor antibodies have a major role in the hypercoagulability state.


Eligibility criteria:
inclusion criteria: * stroke diagnosis * blood sampling within 36hrs from the event * written agreement exclusion criteria: * a stroke, mi or major operation prior to the current stroke * hypercoagulable state known in this patient * a severe chronic disease known at the time of the stroke * an infection on arrival (based on anamnesis, physical exam and lab tests) * thrombolytic treatment

Keywords: apla aps stroke minor anti body major anti body apla antibodies in serum
motor control prevention strategies in basketball players

Conditions: Ankle Sprains; Motor Disorders

Summary: ankle sprains have always been considered as isolated injury entities, in which the passive ankle stabilisation system suffered an elongation due to trauma. today, this concept of an isolated injury has evolved into a more holistic concept, interrelated with various components from different sources.


Eligibility criteria:
inclusion criteria: * basketball players aged between 10-18 years old who play regularly in one of the basketball clubs in the city of salamanca. exclusion criteria: * previous injuries * fractures * use of orthoses and technical aids
the effect of massage on growth and stress and stress ,department of nursing,

Conditions: Preterm

Summary: the aim of this thesis is to exprementally investigate the effect of massage applied to preterm infants on growth and stress. while the population of the research is preterm infants at the neonatal intensive care unit of a medicalpark batman hospital between january 2018 and february 2019, the sample is 60 preterm infants suitable for inclusion criteria. research data was collected using preterm infant information form, preterm follow-up form and newborn stress scale. while massage was applied to the infants in the experimental group three times daily for 10 days, the control group received the usual care. weight, length and head circumference of infants in both experimental and control group were measured by the researcher on 1., 5. and 10. days. in order to evaluate stess level of the massage applied infants, camera records of the infants were taken 15 minutes before and after the massage on 1., 5. and 10. days. camera records of the infants in the control group were also taken at the same time with those in the experimental group. camera records were watched and stress level of the infants were evaluated by two observers blind to the research. the data analyses were carried out using in-class correlation, frequency, levene, two-way anova for mixed measured, repeated anova tests

the aim of this thesis is to exprementally investigate the effect of massage applied to preterm infants on growth and stress

Eligibility criteria:
inclusion criteria: - gestational age at birth below 36 weeks + 6 days, body weight over 1000 g, do not have any diseases or congenital disorders, babies who are allowed to be massaged by the nicu's neonatologist was determined as . exclusion criteria: -

Keywords: preterm
an observational study on dual and triple therapies based on peginterferon alfa (e.g. pegasys) in patients with chronic hepatitis c

Conditions: Hepatitis C, Chronic

Summary: this prospective, multicenter, observational cohort study will evaluate the efficacy and safety of pegylated interferon alfa (peginterferon alfa) (e.g. pegasys) plus ribavirin and treatment regimens containing direct-acting antivirals in participants with chronic hepatitis c who are treatment-naïve or treatment-experienced and hiv hcv co-infected. data will be collected from participants receiving treatment according to current summary of product characteristics (spc) and local labeling for the duration of their treatment and a 24-week follow-up.


Eligibility criteria:
inclusion criteria: * adult (according to local legislation) participants * chronic hepatitis c (hcv) * naive or treatment experienced, hiv-hcv co-infected or hcv mono-infected * receiving treatment for hcv with pegylated interferons plus ribavirin or regimens containing direct-acting antivirals (daa) according to standard of care and in line with current spc/local labeling exclusion criteria: * contraindications according to spc/local labeling * treatment started \>4 weeks before entering study
preoperative heart rate variability and baroreflex sensitivity in aso patients during various sleep stages

Conditions: Arteriosclerosis Obliterans

Summary: the goal of this study is to evaluate the possible preoperative predictive value of altered heart rate variability (hrv) and baroreflex sensitivity in different sleep stages for postoperative adverse cardiac events (i.e. arrhythmia or myocardial ischemia needing hospitalization or medication, myocardial ischemia assessed by enzyme release, myocardial infarction, sudden cardiac death, stroke) in arteriosclerosis obliterans patients.


Eligibility criteria:
inclusion criteria: * age \> 40 years * aso * elective vascular surgery patient (i.e. infra-inguinal bypass procedure) exclusion criteria: * other than sinus rhythm * lack of co-operation * major surgery less than 3 months preoperatively * sleep apnoea * dialysis treatment * cabg less than 3 years earlier