Kornimate/medical-research-clean huggingface dataset:
lifetime risk for cardiovascular disease among non-white ethnic groups

Conditions: Cardiovascular Diseases; Coronary Disease; Heart Failure, Congestive; Atrial Fibrillation

Summary: cardiovascular disease (cvd) is one of the leading causes of death in the united states. currently, there is little information about the lifetime risk of cvd among non-white ethnic groups. this study will analyze data from participants in several ongoing clinical studies to identify the lifetime risk for cvd among various ethnicities.

cvd affects millions of people in the united states. current treatment guidelines for cvd take into account an individual's risk of developing the disease within 10 years; the intensity of therapy is usually matched to the 10-year risk magnitude. however, many individuals have a low 10-year risk of cvd, but have an elevated lifetime risk of developing the disease. unfortunately, few studies have examined the lifetime risks for cvd, and these studies have been almost exclusively performed in the caucasian population. there have been no studies that focus on the lifetime risks for cvd among other ethnic groups. because the incidence of cvd and other causes of death vary among different ethnic groups, it is important to examine each group separately. using data from ongoing clinical studies, this study will evaluate the lifetime risks for cvd among different ethnic groups. the results from this study will assist in estimating the future incidence of cvd among ethnic groups, improving risk communication within patient care, and identifying new populations of individuals at risk for cvd. this study will use previously collected data on 500,000 individuals participating in pre-specified clinical studies. some of the participating studies include the following: atherosclerosis risk in communities, framingham heart, honolulu heart, puerto rico heart health, coronary artery risk development in young adults (cardia), cardiovascular health, chicago heart association detection project in industry, women's health initiative observational studies, and multiple risk factor intervention trial (mrfit). there will be no study visits specifically for this study. researchers will collect information on cvd risk factors and demographics, including sex, race, and age; they will then compare this information to overall survival, cvd associated survival, and lifetime risk for cvd.

Eligibility criteria:
inclusion criteria: * participating in a specified epidemiologic study exclusion criteria: * pre-existing cvd prior to study entry

Keywords: coronary heart disease risk factors heart failure
capecitabine plus pyrotinib versus capecitabine plus trastuzumab and pertuzumab in the first-line treatment of her2-positive metastatic breast cancer

Conditions: Metastatic Breast Cancer

Summary: this is a randomized, multicenter phase 2 clinical trial to evaluate the efficacy and safety of capecitabine plus pyrotinib versus capecitabine plus trastuzumab plus pertuzumab in patients who have her2 positive metastatic breast cancer and have not received systemic anticancer therapy for advanced disease.


Eligibility criteria:
inclusion criteria: * her2 positive recurrent or metastasis breast cancer. * patients with measurable disease are eligible. * eastern cooperative oncology group(ecog) performance status 0 or 1. * adequate organ function. * signed, written inform consent obtained prior to any study procedure. exclusion criteria: * history of anti-cancer therapy for mbc（with the exception of one prior hormonal regimen for mbc）. * history of her tyrosine kinase inhibitors or monoclonal antibody for breast cancer in any treatment setting，except trastuzumab used in the neo-adjuvant or adjuvant setting. * assessed by the investigator to be unable receive systemic chemotherapy. * history of other malignancy within the last 5 years，except for carcinoma in situ of cervix，basal cell carcinoma or squamous cell carcinoma of the skin that has been previously treated with curative intent. * pregnant or lactating women，or for women of childbearing potential unwilling to use a highly-effective contraception during of the study treatment and for at least 7 months after the last dose of study treatment.
clinician managed interpersonal psychotherapy

Conditions: Depression; Depression, Postpartum

Summary: this 12-week study will evaluate the effectiveness of clinician-managed interpersonal psychotherapy (cm-ipt) in treating postpartum depression and will compare cm-ipt to standard ipt.

cm-ipt is delivered in 12 sessions over the course of a year. standard ipt is delivered in 12 sessions in the first 12 weeks after treatment assignment.

Eligibility criteria:
inclusion criteria: * women between 8 and 24 weeks postpartum * meet dsm-iv criteria for major depression * hamilton rating scale for depression score of 12 or more exclusion criteria: * active substance abuse * psychotic disorders
split wound comparison of trichophytic closure techniques for donor site in hair transplantation

Conditions: Androgenetic Alopecia

Summary: this study aim to compare cosmetic results between 3 trichophytic closure techniques for donor site (the trimming of upper, lower and both edge of linear incision) in hair transplantation.

strip harvesting technique, a conventional hair transplantation procedure, is widely used in the treatment of androgenetic alopecia for more than half a century. it provides less time-consuming, more feasible and more cost-effective comparing with follicular unit extraction (fue) technique. however, linear scar at the donor site is also introduced. the latest method to fine the scar at the donor site was invented and known as 'trichophytic closure technique'. it can be done by trimming upper or lower wound edge for about 1 millimeter (as fig.1) before wound closure. then the linear scar will be less visible after hair growth. anyway, there is no exactly wound edge (upper, lower or both) that recommended for the excellent cosmetic results without any severe side effects. therefore, this study was designed to determine which is the best trichophytic closure technique. this research is a pilot, split-wound comparison study of trichophytic closure techniques for donor site in hair transplantation.10 males, aged ≥ 25 years, who require strip harvesting follicular unit transplantation in the treatment of androgenetic alopecia will be enrolled. preoperative and perioperative process will be conducted as standard procedure except wound closure technique. each incision wound of donor site will be equally divided into 3 parts (marked with tattoos as fig.2) and each part will be randomly treated with different trichophytic closure techniques as below. * the 1-millimetre trimming of upper edge of linear incision before wound closure * the 1-millimetre trimming of lower edge of linear incision before wound closure * the 0.5-millimetre trimming of both edge of linear incision before wound closure for evaluation, we have planned to assess both cosmetic results and side effects as shown in the table. ( table 1 - image file ) after data collecting process, we have planned to analyze the demographic data, rate of infection and other side effects in a descriptive manner. however, the evaluation for cosmetic results will be analyzed by paired t-test in the same technique at different follow up period and by one-way anova between each technique at the same follow up period.

Eligibility criteria:
inclusion criteria: * male * age of 25 or more * diagnosis of androgenetic alopecia * do not response to conventional treatment and undergo hair transplantation surgery exclusion criteria: * have skin lesion at donor site * psychological disturbance including trichotillomania * anti-hiv positive

Keywords: trichophytic closure hair transplantation donor site androgenetic alopecia
the comparison of quality of life in patients with pancreatogenic diabetes after pancreatectomy

Conditions: Quality of Life; Diabetes Mellitus; Pancreatectomy

Summary: background: pancreatogenic diabetes resulted from total pancreatectomy(tp) is one of the reason why this form of surgery technique is seldom performed. however, with the progress of medical and surgical care nowadays, patients undergone tp could receive better care in endocrine and exocrine insufficiency. in addition, with better understanding of benign pancreatic tumors and pancreatic neuroendocrine tumors, more patients with diffused pancreatic disease are diagnosed; hence, the performance of tp may rise. nevertheless, the quality of life of patients with pancreatogenic diabetes after tp is still currently controversial. purpose: the purpose of this study is to (1) explore the association of fatigue, self-care activities and quality of life in patients with pancreatogenic diabetes after total pancreatectomy; (2) compare the data with diabetic patients after pancreaticoduodenectomy. method: a correlational and comparative cross-sectional approach will be used. the data will be collected with a structured questionnaire via purposive sampling of 120 subjects in an outpatient pancreatic surgical department. inclusion criteria will be the patients with: (1) age 20 or above, (2) conscious clear, can communicate in mandarin or taiwanese, (3) agree to participate in the study and sign informed consent. exclusion criteria will be the patients diagnosed with cancer other than pancreatic cancer and under active treatment. data will go through propensity score matching and will be analyzed by using descriptive statistics, paired t-test, chi square test, pearson's correlation, and conditional logistic regression. anticipated achievement: the anticipated achievement of this study is to understand the relationships between fatigue, self-care activities, and quality of life in patients with pancreatogenic diabetes after pancreas surgery. in addition, through this study, the influence of diabetes to patients after pancreatic tumor resection can be explored; and the factors that influence the population's quality of life can be examined. by the filling of this knowledge gap, intervention can be planned accordingly to help improve the population's quality of life.


Eligibility criteria:
inclusion criteria: * (1) age 20 or above, (2) conscious clear, can communicate in mandarin or taiwanese, (3) agree to participate in the study and sign informed consent exclusion criteria: * diagnosed with cancer other than pancreatic cancer and under active treatment

Keywords: quality of life diabetes mellitus pancreatectomy
effects of physical therapy and dalfampridine on functional mobility in non ambulatory persons with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the goal of this interventional double blind, randomized placebo controlled trial was to assess the change in functional mobility, quality of life and cognition for subjects who receive physical therapy and take dalfampridine vs those who receive physical therapy and take a placebo in non ambulatory persons with multiple sclerosis. the main question\[s\] it aims to answer are: 1. does the addition of dalfampridine to physical therapy improve functional outcomes compared to physical therapy alone 2. does physical therapy improve functional outcomes in patients who are non ambulatory

this randomized control trial examined the effectiveness of dalfampridine when administered in conjunction with 12 weeks of physical therapy compared to physical therapy and a placebo on function, quality of life (qol) and cognition in non-ambulatory pwms. specific aim 1: assess the change in standing tolerance, transfers, repeated sit to stand, qol and cognitive processing for non-ambulatory individuals with ms between subjects on dalfampridine who receive physical therapy and those who participate in physical therapy and receive a placebo. enhancing the propagation of action potentials along axons in addition to regularly contracting the muscles through exercise may have a greater effect on strength and functional mobility. specific aim 2: assess the functional, strength and cognitive changes within all subjects receiving pt 2x a week for 12 weeks. evidence supporting the effectiveness of physical therapy in this population is extremely limited.

Eligibility criteria:
inclusion criteria: * age 20 years or older confirmed ms diagnosis * expanded disability status scale (edss) of 7.0 or higher * no steroid treatment in the last 30 days or a relapse in the last 90 days, and ms considered stable * capable of performing requirements of physical therapy (pt) treatment including at least a 2/5 manual muscle test in 50% or more of the major muscle groups exclusion criteria: * history of seizure disorder * major cognitive or mental illness that prevented their ability to provide consent * evidence of other medical cause of cognitive impairment besides ms * severe joint contractures that limited the patients ability to move within full active range of motion

Keywords: dalfampridine functional mobility non ambulatory cognition quality of life
studying the performance of oct c-scan in the screening for retinopathy related to synthetic antimalarials

Conditions: Toxicity, Drug; Maculopathy

Summary: maculopathy induced by retinal toxicity of synthetic antimalarials is to be screened at the sub-clinical stage. indeed, when the first visual symptoms appear, macular damage is already irreversible and the clinical picture may even continue to deteriorate for several years after the end of synthetic antimalarial use. in opposition, the early termination of hydroxychloroquine in patients showing recent alterations on the multifocal electroretinogram (nferg) allowed he reversibility of toxic damage over a six month period. it is therefore critical to detect early retinal anatomic changes during retinotoxicity screening before the occurrence of irreversible anatomical and functional consequences. the usual patient monitoring consists of an annual eye examination, detecting subjective functional abnormalities (visual acuity, color vision, central visual field testing) or macular lesions (eye fundus). these abnormalities show a constituted infringement and do not contribute to the early diagnosis of synthetic antimalarial maculopathy. the mferg is an objective examination, able to detect retinal damage whilst still reversible. it is recommended during the annual monitoring and is, today, the gold standard for the screening and diagnosis of synthetic antimalarial maculopathy. however, its realization is time consuming, requires a good patient cooperation and is difficult to access due to the few ophthalmology centers offering it. in practice, it is rarely done as a systematic annual screening for patients on long-term synthetic antimalarial treatment. it is often limited to second-line studies (for patients already showing functional or anatomical abnormalities) whereas its interest lies in the detection of early lesions. the optical coherence tomography spectral domain (oct-sd) is a non-invasive eye examination, commonly used since nearly 10 years. a special image analysis provides a panoramic viewing of the state of the photoreceptor layer, and a non-invasive detection of any anatomical changes, even subtle, within this layer. the concordance between the "en face" oct and the mferg in the screening of synthetic antimalarial maculopathy is considered in this study.


Eligibility criteria:
inclusion criteria: * patients treated with synthetic antimalarials for at least 5 years exclusion criteria: * state of ocular structures preventing the realization of exams
tops for african american breast cancer survivors

Conditions: Feasibility and Acceptability of the TOPS Program; Obesity; Breast Cancer; Weight Loss

Summary: for women diagnosed with breast cancer, dietary, weight loss, and physical activity have been linked with clinically significant weight loss; decreased risk of death; reduced risk of breast cancer recurrence; fewer cardiovascular events; and improved physical function. the objectives of these aims are to a) determine if the tops materials and format are possible and accepted by overweight and obese african american breast cancer survivors; b) gather data for sample size calculations for a larger future study. to meet these aims, we will collect data to see if participants enjoyed the tops program and suggestions for changes to the program to make it fit their needs. other methods will measure recruitment, retention, and weight change. aim 1: examine the feasibility and acceptability of a national, low-cost, community-based, peer-led, weight loss program (take off pounds sensibly, tops) for overweight and obese african american breast cancer survivors in the local chapter of a national african american breast cancer support group (sisters network triangle north carolina, sntnc). aim 2: assess the weight change of overweight and obese african american breast cancer survivors after 6 months in the tops program to gather data for sample size calculations for a future rct (randomized controlled trial).


Eligibility criteria:
inclusion criteria: * women diagnosed with breast cancer with bmi ≥ 25 kg/m after completion of primary 2 therapy (surgery, radiation, adjuvant or neo-adjuvant chemotherapy). exclusion criteria: * women whose oncology providers do not agree with their participation in a weight loss program or those participating in another weight loss program.
use of smss to improve attendance to cervical cancer follow-up screening

Conditions: Cervical Cancer

Summary: this study evaluates the effect of the sms intervention 'connected2care' on the attendance rate to cervical cancer screening follow-up appointments.

connected2care is a non-blinded, multicentre, parallel-group, randomised controlled trial. tanzanian women testing positive to hr hpv at inclusion are randomly assigned in an allocation ratio of 1:1 to the sms intervention or the control group (standard care). in a period of 10 months, the intervention group will receive 15 one-directional health educative text messages and sms-reminders for their appointment. the total sample size will be 700 with 350 women in each study arm. primary outcome is attendance rate for follow-up. secondary objectives are cost-effectiveness measured through incremental ratios and knowledge of cervical cancer by a 16-item true/false scale questionnaire at baseline and follow-up.

Eligibility criteria:
inclusion criteria: * informed consent * hpv positive * age 25 - 60 years * private mobile phone exclusion criteria: * pregnant on day of enrolment * menstruating on day of enrolment * hysterectomy * diagnosed with cervical pre-cancer within past 12 months * diagnosed with cervical cancer * invalid mobile phone number * unreachable when trying to convey hpv positive result

Keywords: mobile health screening early detection of cancer hpv sms intervention rct tanzania
gold factor on knee joint health and function

Conditions: Knee Arthritis; Knee Osteoarthritis; Knee Pain Chronic; Knee Discomfort; Rheumatoid Arthritis; Knee Pain Swelling

Summary: the purpose of this clinical study was to determine whether gold nanoparticles (aunp) supplement holds clinical value in improving joint health, function, and quality of life for arthritis patients.

the purpose of this clinical study was to determine whether gold nanoparticles (aunp) supplement holds clinical value in improving knee joint health, function, and quality of life for arthritis patients. a total of 51 participants were followed for 20 weeks through a three phase longitudinal study. both subjective and objective parameters were used to measure and monitor changes in knee joint health and function, as well as quality of life.

Eligibility criteria:
inclusion criteria: * ≥ 18 and \<87 years of age * having arthritis * suffering from chronic knee pain * failed treatments to date - including surgery, physical therapy, nsaids * must agree to maintain the same eating, exercise, and sleep arrangements for the whole duration of the study exclusion criteria: * having bacterial, intra-articular, or knee infections * had any knee related partial or complete total knee replacement within 3 months prior to the start of the study * had recent (3 months prior to start of the study) knee injection * currently on nsaids * currently pregnant or lactating

Keywords: knee joint health arthritis gold nanoparticles (aunps) knee joint function osteoarthritis rheumatoid arthritis
a i in the prediction of clinical performance, marginal fit and fracture resistance of vertical versus horizontal margin designs fabricated with 2 ceramic materials

Conditions: Artificial Intelligence

Summary: the present study will be performed to evaluate application of artificial intelligence in the prediction of clinical performance, marginal fit and fracture resistance of vertical "feather-edge" versus horizontal "shoulder" margin designs fabricated with two ceramic materials (zirconia and hybrid ceramic)

the objective of the present study is to characterize two different margin designs (vertical "feather-edge" and horizontal "shoulder") with two different ceramic materials (zirconia and hybrid ceramic) in terms of clinical performance, marginal fit and fracture resistance. primary outcome: predicting the follow up results using the new (artificial intelligence "ai") model for vertical "feather-edge" versus horizontal "shoulder" margin designs fabricated with two ceramic materials (zirconia and hybrid ceramic) that saves the clinical evaluation period, hence saves the expenses of the dental clinic. secondary outcome: evaluating the clinical performance, marginal fit and fracture resistance of vertical "feather-edge" versus horizontal "shoulder" margin designs fabricated with two ceramic materials (zirconia and hybrid ceramic).

Eligibility criteria:
inclusion criteria: * 1. age range of patients should be 20-50 years old, able to read and sign the informed consent document. 2. patient with posterior molars indicated for full coverage restorations. 3. patient should be able to physically and psychologically tolerate conventional restorative procedures. 4. patients who are willing to return for follow-up examination and evaluation. 5. indicated molar should have adequate tooth preparation length to ensure proper retention and resistance form. 6. patient with sound contralateral or adjacent tooth to the selected tooth requiring full coverage restoration. exclusion criteria: 1. patient in the growth stage with partially erupted teeth. 2. patient with poor oral hygiene and motivation. 3. pregnant women. 4. patient with psychiatric problems or unrealistic expectations. 5. patients with no opposing occluding dentition in the area intended for restoration. 6. patients with parafunctional habits. -
retrospective study of implants with peri-implantitis surgically treated using enamel matrix derivative (emd)

Conditions: Determination of Beneficial Effect of Using Enamel Matrix Derivative During Implant Treatment

Summary: the existing records of a private practice limited to the practice of periodontology were reviewed to locate patients who had been diagnosed with peri-implantitis (failing dental implant) and had been surgically treated utilizing enamel matrix derivative (commercially available fda product emdogain sold by straumann usa). various clinical factors were gathered from the existing records. some of the factors recorded were: retention of the implant, presence of bleeding, presence of further damage, and presence of inflammation. all patients had signed an informed consent for treatment and the anonymous use of their data for research purposes. all hipa requirements were followed.

see brief summary.

Eligibility criteria:
inclusion criteria: * all adult patients of record who presented with existing peri-implantitis that was clinically deemed treatable (the implant was not considered hopeless.) exclusion criteria: * none except for routine medical contraindications for periodontal surgery

Keywords: dental implant peri-implantitis enamel matrix derivative