Kornimate/medical-research-clean huggingface dataset:
deps-r turkish version in adults with type 1diabetes

Conditions: Type 1 Diabetes

Summary: a growing body of research has revealed the good psychometric properties and three-component factor structure of deps-r in children and adolescents with type 1 diabetes (t1d) but research with adults has limited and has differing results. the diabetes eating problem survey-revised (deps-r) developed by markowitz et al is a diabetes-specific self-report instrument to screen eating disorders for individuals with t1d. deps-r is a 16-item diabetes-specific self-report questionnaire to test for diabetes-specific eating disorders. answers are scored on a six-point likert scale, with higher scores indicating more deb and a total score of ≥20 indicating a high risk for eating disorders (range 0-80). the original deps-r has been shown to have a good internal consistency (cronbach's alpha=0.86) and construct validity in a sample of the pediatric population with t1d. this study aimed to evaluate the validity and reliability of the turkish version of the deps-r questionnaire for adults with t1d, investigate its psychometric properties and factor structure, and examine its relationship with the ede-q questionnaire.

in this cross-sectional study, participants answered a deps-r and ede-q questionnaire during a regularly scheduled medical visit after obtaining written informed consent. all participants had established that patients with t1d were treated with multiple daily insulin or insulin pump therapy. height was measured using a stadiometer to the nearest 0.1 cm in all participants. weight was measured unclothed to the nearest 0.1 kg using a calibrated balance scale. body mass index (bmi) was calculated by using the weight (kg)/height (m²) equation. clinical data including hba1c, t1d onset, birth date, and treatment model etc. was conducted as part of a standard clinical assessment. hba1c was measured with ion-exchange high-performance liquid chromatography (bio-rad variant ll turbo, japan).

Eligibility criteria:
inclusion criteria: * duration of t1d ≥1 year * a regular follow-up for at least 1 year (4 visits/year) * no major medical problems related to nutrition exclusion criteria: * have major medical problems related to nutrition ( etc. celiac disorders, cystic fibrosis, dyslipidemia,.....)

Keywords: type 1 diabetes deps-r confirmatory factor analysis diabulimia distributed eating disorder
registry study of neoadjuvant chemoradiation & transplant for cholangiocarcinoma patients

Conditions: Cholangiocarcinoma

Summary: this is an observational study intended to validate results of a previous study done at the mayo clinic. patients are treated with combination chemotherapy and radiation and maintained on oral xeloda until they can receive liver transplant. a staging laparotomy is performed before chemoradiation in order to identify patients who will most benefit from the treatment and to improve outcomes.


Eligibility criteria:
inclusion criteria: 1. diagnosis of cholangiocarcinoma that has been established preoperatively by at least one of the following criteria: 1. a positive brush cytology or biopsy result obtained at the time of cholangiography; 2. fluorescence in situ hybridization demonstrating aneuploidy; 3. a serum ca 19-9 value greater than 100 u/ml in the presence of a radiographically characteristic malignant stricture in the absence of cholangitis. 4. listed for olt for hilar cholangiocarcinoma 2. tumor/stricture is above the cystic duct and is unresectable. 3. a suitable candidate for orthotopic liver transplantation as judged by the liver transplant team. all 3 treatment modalities are not needed to confirm eligibility for this registry trial. 4. \>/= 18 years of age. 5. willing and able to provide written informed consent.

Keywords: cholangiocarcinoma observational
blue sky study: impact of milk and vitamin d for child growth and health

Conditions: Vitamin d Deficiency

Summary: this intervention study will address the impact of vitamin d fortified milk and vitamin d supplements on the growth, levels of vitamin d, insulin-like growth factor 1, growth hormone, academic attention, respiratory infections, asthma, and flexural dermatitis (a proxy for eczema) of mongolian children.


Eligibility criteria:
inclusion criteria: * children in 3rd and 4th grade from selected mongolian schools. * school selection will consider: * socioeconomic position; * geographic location; * school size; * current lunch or supplementation program; and * the interest and willingness to participate of the school's administration and faculty. exclusion criteria: * allergy to milk or wheat products.

Keywords: vitamin d children mongolia
efficacy of ultrasound guided external oblique intercostal plane block for subcostal nephrectomy

Conditions: Postoperative Pain

Summary: the patients will be randomly allocated into two equal groups using a computer program. group a: will receive external oblique intercostal block after induction. group b: will receive postoperative morphine per patient request.

general anaesthesia induction will be achieved using fentanyl 1µg/kg (iv), propofol 2mg/kg (iv), and0.5mg/kg of iv atracurium. general anaesthesia will be maintained with mechanical ventilation with isoflurane with o2 \\ air mixture. during anaesthesia maintenance intraoperatively, if bp or heart rate (hr) increase more than 20% from baseline, intravenous morphine will be given to stabilize the patients' haemodynamics. all patients will receive 1g intravenous paracetamol and 4mg ondansetron 8mg dexamethasone.

Eligibility criteria:
inclusion criteria: - eligible patients will be older than 18 years old with american society of anestheologist asa physical status i, ii and iii scheduled for trans-abdominal ( anterior subcostal) nephrectomy exclusion criteria: * patients who are: * unable to cooperate. * patients who have allergy to any of the study drugs. * patients who are on opioids. * known abuse of alcohol or medication. * local infection at the site of injection or systemic infection. * pregnancy * patients with coagulation disorders or on anticoagulation therapy
interest of the induction with target-controlled inhalation of sevoflurane on spikes wave occurrence

Conditions: General Anesthesia

Summary: sevoflurane is widely used for induction of anaesthesia. several studies showed eeg abnormalities during mask induction with sevoflurane. the aim of our study was to test the induction target concentration of sevoflurane on the spikes wave occurrence.


Eligibility criteria:
inclusion criteria: * programmed gynecological surgery * asa 1 or 2 exclusion criteria: * arterial hypertension * gastro-oesophageal reflux * pregnancy * diabetes * obesity * asthma * tobacco

Keywords: général anesthesia gynecology
clinical trial of cryotherapy versus postoperative laser photocoagulation

Conditions: Rhegmatogenous Retinal Detachment

Summary: the purpose of this randomized clinical trial was to compare reattachment rates among patients with rhegmatogenous retinal detachment who underwent scleral buckle surgery with retinopexy by cryotherapy versus postoperative (one month) laser photocoagulation.

the purpose of this randomized clinical trial was to compare reattachment rates, visual acuity results and epiretinal membrane formation among patients with rhegmatogenous retinal detachment who underwent scleral buckle surgery with retinopexy by cryotherapy versus postoperative (one month) laser photocoagulation.

Eligibility criteria:
inclusion criteria: * primary rhegmatogenous retinal detachment with a single peripherical retinal break. all patients were phakic, under eighteen years old, with partial posterior vitreous detachment, visual loss or symptoms (floaters and photopsia) less than 30 days exclusion criteria: * no patient had a retinal break greater than 30 degrees, or retinal detachment larger than two quadrants, history of uveitis or infectious retinopathy, presence of proliferative vitreoretinopathy (b or c), macular disease, glaucoma, hemoglobinopathy, diabetic retinopathy, and history of trauma or previous vitreoretinal surgery.

Keywords: rhegmatogenous retinal detachment cryopexy photocoagulation
non-invasive objective assessment of hemodynamics in preterm neonates

Conditions: Hypotension and Shock; Hypoperfusion; Hemodynamic Instability; Intraventricular Hemorrhage; Cardiac Function; Circulatory Transition

Summary: study type: prospective observational trial study design: longitudinal population: preterm newborns \<32 weeks gestational age hypothesis: the inclusion of non-invasive physiological measures of cardiac output, peripheral perfusion and brain oxygenation (nirs) for preterm neonates is feasible and reveals additional information on the hemodynamic status compared to blood pressure alone. these measurements can improve the ability to rapidly identify those infants who might benefit from intervention and are correlated with short term clinical outcomes.

understanding neonatal hemodynamics is key to neonatal care. despite decades of research, uncertainty continues as to how best assess impaired hemodynamics. hypotension defined by a low mean arterial blood pressure (mabp) remains a common issue in preterm infants, affecting up to 30% of extremely preterm infants. it is common to focus only on mabp thus neglecting the complex and dynamic (patho)physiology that may be present in newborn infants. providing sufficient cellular oxygenation is the primary task of the circulatory system and different factors may compromise it. in this prospective observational study the investigators will examine various forms of objective non-invasive continuous hemodynamic monitoring methods in very preterm infants 1. for feasibility of non-invasive co measurement (first 20 patients) 2. for reproducibility and correlation of this measurement and echocardiography (first 40 echocardiographic examinations) 3. for prediction of therapy response. 4. for correlation with clinical definitions of hypotension/hypoperfusion 5. for prediction of later clinical problems/complications of prematurity and impaired hemodynamic status.

Eligibility criteria:
inclusion criteria: * neonates of 23 weeks 0 days to 31 weeks 6 days * nirs/non-invasive cardiac output - device available * parental informed consent exclusion criteria: * congenital anomalies * major cardiac defects * hydrops * parents decline to consent to the study

Keywords: objective hemodynamic multimodal monitoring premature preterm infant
telehealth to improve functional status and quality of life in veterans with pad

Conditions: Peripheral Artery Disease

Summary: the present study aims to increase veteran access to supervised exercise therapy and expand its role in improving functional status, quality of life, and cardiovascular risk profile of veterans with pad.

the investigators will use the va telehealth service to deploy a remotely accessible supervised exercise training program and evaluate whether a telehealth-based intervention can improve walking performance, quality of life, and ultimately cardiac risk in veterans with pad. the impetus for the current proposal stems from the following: 1) over 50% of va-enrolled veterans live in rural communities; 2) veterans with pad are older (mean age, 70 years), further increasing their risk for functional decline; and 3) there is a significant lack of access to facility-based supervised exercise training for veterans with pad. the objectives include the following: 1. to develop a telehealth-facilitated exercise intervention for veterans with pad that serves as a veteran centric new model of care. 2. to integrate veteran preferences into the development of a telehealth-facilitated supervised exercise program. 3. to assess the long-term patterns of functional impairment and quality of life among veterans with pad not undergoing supervised exercise training.

Eligibility criteria:
inclusion criteria: * diagnosis of pad, defined as a history of an ankle-brachial index (abi) of 0.90, prior revascularization of a lower limb for symptomatic disease more than 30 days prior to presentation, or abi \>0.90 with evidence of pad based on noninvasive vascular laboratory testing or angiography * \[and presence of claudication, defined as fatigue, discomfort, cramping or pain of vascular origin in the muscles of the lower extremities that is consistently induced by exercise and consistently relieved by rest within 10 minutes.\] * in addition, participants will require access to cellular signal at place of residence and/or exercise location exclusion criteria: * justification for exclusion criteria centers on inability to safely participate in the remote intervention. specific exclusion criteria includes the following: * major lower extremity amputation * critical limb ischemia * inability to ambulate without a walker or wheelchair * significant visual or hearing impairment * individuals whose function is limited by severe conditions such as severe ischemic heart disease or \> class ii nyha heart failure * individuals capable of ambulating at a level comparable to the amount of exercise to be prescribed at baseline * individuals currently enrolled in another exercise trial or cardiac rehab program * individuals with uncontrolled psychiatric illness or dementia * categorically vulnerable * pregnant women, prisoners, children, or persons who lack decision-making capacity
movement disorders caused by antipsychotic drugs in older patients

Conditions: Dyskinesia, Drug-Induced

Summary: this study will assess the risk of experiencing tardive dyskinesia and other movement disturbances associated with three atypical antipsychotic drugs among middle-aged and elderly psychiatric patients.

use of antipsychotic drugs can result in tardive dyskinesia and extrapyramidal symptoms. tardive dyskinesia (td) is a syndrome that causes repetitive, involuntary, purposeless movements in the tongue, lips, or jaw. it can also cause facial grimacing, random movements of arms, legs, fingers, and toes, as well as swaying movements of the trunk or hips. extrapyramidal symptoms (eps) include a variety of symptoms, such as involuntary movements, tremors, rigidity, body restlessness, and changes in breathing and heart rate. td and eps are side effects of older antipsychotic drugs. newer antipsychotic drugs, such as quetiapine, olanzapine, and risperidone, do not present as large a risk of developing these side effects. this study will assess the incidence of and risk factors for tardive dyskinesia and extrapyramidal symptoms associated with quetiapine, olanzapine, and risperidone among middle-aged and elderly individuals with psychotic disorders. additionally, the study will examine the effect of these drugs on symptoms of pre-existing, drug-induced td. it will also explore the impact of movement disorder symptoms on everyday functioning and quality of life. some participants in this open-label study will be randomly assigned to receive quetiapine, olanzapine, or risperidone. participants who are not randomly assigned to a medication will still receive one of the three medications, based on the decision of their physician. initial evaluations will be conducted to collect demographic information, as well as medical, psychiatric, and pharmacologic histories. dosing will be determined by each participant's psychiatrist. all participants will be followed for approximately 5 years. they will report to the study site for outcome assessments at baseline, months 1 and 3, and every 3 months for the remainder of the study.

Eligibility criteria:
inclusion criteria: * dsm-iv diagnosis of any psychiatric disorder for which an antipsychotic medication is needed exclusion criteria: * n/a

Keywords: schizophrenia neuroleptic tardive dyskinesia
cognoa asd diagnostic device - data collection study

Conditions: Autism Spectrum Disorder

Summary: the primary objective of this study is to collect data to ascertain the ppv and npv of the current version of the cognoa diagnostic device. a secondary objective is to collect data, in the form of additional questions, in order to train new algorithms related to children's developmental and behavioral conditions.


Eligibility criteria:
inclusion criteria: * ≥ 18 months of age and \< 72 months of age * functional english capability in the home environment * documented parental and/or clinician concern for developmental delay * participants must have a smartphone capable of downloading the cognoa app (cognoa supports ios 10.0 and up, android 6.0 and up) exclusion criteria: * children with suspected auditory or visual hallucinations or with prior diagnosis of childhood onset schizophrenia. * children with known sensory impairment such as deafness or blindness * children with known physical impairment affecting their ability to use their hands * children with major dysmorphic features or prenatal exposure to teratogens (such as fetal alcohol syndrome) * children with history or diagnosis of genetic conditions (such as rett's syndrome or fragile x) * children with microcephaly * children with history or prior diagnosis of epilepsy or seizures * children with history of or suspected neglect * children with history of brain defect, injury or insult requiring interventions such as surgery or chronic medication * children whose age on the date of enrollment is outside the target age range * children who have been previously enrolled in any cognoa clinical study or survey * children whose medical records had been included in any internal cognoa training or validation sets
rehabilitation of fatigue in patients with post-covid-19 syndrome

Conditions: Post-COVID-19 Syndrome

Summary: more than half of patients with post-covid-19 syndrome experience fatigue. rehabilitation is needed to treat this persistent symptom. the aim of this study is to conduct a rehabilitation intervention to treat patients with post-covid-19 syndrome who experience persistent fatigue.

* background: more than half of patients with post-covid-19 syndrome experience fatigue. rehabilitation is needed to treat this persistent symptom. * objectives: to conduct a rehabilitation intervention to treat patients with post-covid-19 syndrome who experience persistent fatigue. * methodology: randomized clinical trial. there will be 3 groups. * patients will be recruited from the virgen de las nieves university hospital in granada. * the evaluation will be carried out at the university of granada. * the rehabilitation will be carried out at the university of granada and/or patient's home.

Eligibility criteria:
inclusion criteria: * diagnosis of covid-19 * post-covid-19 syndrome * adults ≥ 18 y \< 75 años * be medically stable * to be able to walk * not currently participating in a rehabilitation programme and/or other study. * fatigue: fss ≥ 36 puntos * basic knowledge * wish to participate in the study and sign the informed consent exclusion criteria: * patients with severe comorbidities that interfere with the ability to perform the study * patients with mental, physical or organic problems that under medical criteria may pose a risk to the patient

Keywords: covid-19 post-covid-19 syndrome fatigue
monitoring hdr brachytherapy for cervical cancer by optic and thermal imaging

Conditions: MALIGNANCY

Summary: this research aims to investigate the correlation between tumor temperature difference and biological factors, such as size, metabolism, treatment response, and tumor aggressiveness. in addition, normal tissue response to radiation therapy in treated organ will be evaluated.


Eligibility criteria:
inclusion criteria: * signed informed consent * biopsy proven cervical cancer which will undergo definitive radiation exclusion criteria: * not eligible to sign informed consent
pain management after forefoot surgery

Conditions: Postoperative Pain

Summary: the purpose of this study was to compare the efficacy of transdermal fentanyl to placebo both administered together with peroral nonsteroidal antiinflammatory drug (nsaid) and paracetamol in treatment of postoperative pain after hallux valgus or hallux rigidus surgery.


Eligibility criteria:
inclusion criteria: * unilateral hallux valgus or hallux rigidus surgery * 18-75 yrs old * asa i-iii exclusion criteria: * previous history of intolerance to the study drug * history of alcoholism * drug abuse * psychological or other emotional problems that are likely to invalidate informed consent * sleep apnoea * bmi ≥ 35 kg/m2

Keywords: hallux valgus forefoot transdermal fentanyl
a study comparing the efficacy and safety of abt-652 to placebo in subjects with diabetic neuropathic pain

Conditions: Diabetic Neuropathic Pain

Summary: to evaluate the safety and efficacy of abt-652 compared to placebo in subjects with diabetic neuropathic pain. people with diabetes can, over time develop nerve damage throughout the body with symptoms such as pain, tingling, or numbness (loss of feeling) in the hands, arms, feet and legs.

a double blind, randomized, active- and placebo-controlled 13-week study. duloxetine is added to evaluate assay sensitivity.

Eligibility criteria:
inclusion criteria: * subject is between the ages of 18-75 years with a diagnosis of diabetes mellitus and must have a diagnosis of painful distal symmetric diabetic polyneuropathy and presence of ongoing pain due to diabetic peripheral neuropathy for at least 6 months. * subject must have a mean average score of greater than 4 on the 24 hour average pain score (0-10 numerical rating scale) prior to the baseline visit. * subject has been on a medication for diabetic neuropathic pain for the past 3 months. exclusion criteria: * subject has clinically symptomatic neuropathic pain conditions that cannot be distinguished from diabetic neuropathic pain or interfere with the pain assessments of diabetic neuropathic pain. * a subject has newly diagnosed or clinically significant medical conditions or mental disorders that would preclude participation or would interfere with diabetic neuropathic pain assessments or other functions. * subject has clinically significant abnormalities in clinical laboratory tests. * subject has taken an opioid chronically, excluding tramadol within the last 3 months prior to screening.

Keywords: diabetic neuropathic pain active controlled phase 2 study
listening effort in tinnitus patients

Conditions: Listening Effort; Tinnitus

Summary: about 5-15% of the general population experience a chronic ringing, buzzing, hissing or roaring sound in one or two ears, without any external source. this so-called tinnitus can be present in people with normal hearing, but often coexists with hearing loss. most people suffering from tinnitus can cope with it, however a minority experiences emotional distress or cognitive dysfunction as a result of the tinnitus, called tinnitus disorder. people suffering from tinnitus disorder regularly complain about an increased experienced effort when listening to speech or other sounds in daily life situations. as this has never been proven scientifically, the investigators aim to evaluate the effect of the tinnitus percept and tinnitus disorder on experienced listening effort by comparing listening effort between a population with tinnitus disorder and a population without tinnitus.


Eligibility criteria:
inclusion criteria: * young adults, i.e. 18-69 year old; * pure tone average \<35 db hl (0.5, 1, 2, 4 khz); * proficient and native speaker of dutch language; * tinnitus group: severe unilateral or bilateral tinnitus disorder (tq \> 46). * control group: no tinnitus. exclusion criteria: * significant asymmetric hearing loss: \|ptaright - ptaleft\| \> 15 db (pta = pure tone average of 500, 1000, 2000 and 4000 hz); * significant loss of vision (text on screen at 70 cm should be readable); * frequent user of any of the following devices: hearing aid, bone conduction device, cochlear implant, tinnitus masker; * additional mental or physical disabilities that may prevent active participation and testing as per protocol.