Kornimate/medical-research-clean huggingface dataset:
socket shield technique with or without flap elevation

Conditions: Alveolar Bone Resorption

Summary: it is aimed to compare the bone changes and the amount of marginal bone loss after prosthetic loading around the immediately placed implants using the socket shield technique with or without flap elevation.

temporary prostheses will be applied to patients in the flap and flapless surgery group 1 week after the surgical procedure, and permanent prostheses will be placed 3 months later. from this date, clinical controls will be made in the 1st, 3rd, 6th months and 1st year. during these controls, biological complications (peri-implant mucositis, peri-implantitis), implant failure and survival rates, and complications related to the socket shield (socket shield exposure, infection) will be evaluated. marginal bone loss around the implants and bone resorption in the horizontal and vertical directions will be compared between the two groups with cone beam computed tomography taken at the 1st year follow-up. the oral health-related quality of life scale will be applied in the session where the temporary prosthesis is applied 1 week after the surgery, in the 1st month clinical control and in the 3rd and 6th month clinical control after the permanent prosthesis application, in order to evaluate the quality of life related to the surgical and prosthetic application of the patients in both groups, and comparisons between groups will be made. in addition, intraoral photographs will be taken from the patients for aesthetic evaluation before the surgical procedure, at the 1st, 3rd and 6th month clinical control sessions. pink aesthetic score (pes) and white aesthetic score (bes) will be evaluated on the photographs, and a comparison will be made between groups in terms of scores.

Eligibility criteria:
inclusion criteria: * being systemically healthy (asa classification i-ii) * being over 18 years old * not smoking * having good oral hygiene * upper incisors and premolars that cannot be restored and have extraction indications * periodontally healthy, non-mobile teeth * the amount and quality of bone suitable for immediate implant placement exclusion criteria: * periodontally unhealthy teeth * teeth with vertical root fracture on the buccal surface * teeth with a horizontal fracture below the bone level * teeth with external and internal resorption affecting the buccal part of the root * patients who are pregnant or suspected of pregnancy

Keywords: socket shield technique alveolar bone preservation immediate implantation
probiotics and allergic diseases

Conditions: Atopic Dermatitis; Asthma

Summary: many studies had demonstrated that probiotics could be applied in the prevention and adjuvant treatment for allergic diseases. in this study, we investigate the effects of lactobacillus paracasei gmnl-133(lp), lactobacillus fermentum gm-090 (lf), and lactobacillus paracasei gmnl-133(lp) with lactobacillus fermentum gm-090 (lf) combination products used for adjuvant treatment of atopic dermatitis and asthma.

the main purpose: to investigate if lactobacillus paracasei gmnl-133(lp), lactobacillus fermentum gm-090(lf), lactobacillus paracasei gmnl-133 (lp) with lactobacillus fermentum gm-090 (lf) combination products could be used for the adjuvant treatment of atopic dermatitis and asthma. the secondary objective: to investigate whether probiotics consumption improve the quality of life and allergic symptoms to different people with lactobacillus paracasei gmnl-133 (lp), lactobacillus fermentum gm-090 (lf) and lactobacillus paracasei gmnl-133(lp) and lactobacillus fermentum gm-090 (lf) combination products.

Eligibility criteria:
inclusion criteria: 1. age between 1 year old and 18 years old, 2. ad cases fulfill the diagnostic criteria by hannifin and rajka. 3. atopy as shown by at least one positive skin test (weal size ≧ 3mm) or one positive mast (rast) (ige ≧ 0.7 ku/l) test to any common food or environmental allergens. exclusion criteria: 1. systematic corticosteroid, immunosuppressive therapy, or antimycotics treatment during the 4 weeks, antihistamines, and singulair during the 7 days before enrollment 2. probiotic preparations used within 2 weeks before entering the study 3. use of antibiotics now or other oral medications that will interfere the results 4. if they had immune deficiency disease or other major medical problems 5. if they had participated in another clinical study during the past month. 6. subjects are undergoing desensitization therapy within 3 months prior to the screening period. 7. subjects have participated investigational drug trial within 4 weeks before entering this study. 8. subjects are pregnant, lactating or planning to become pregnant. 9. subjects with any other serious diseases considered by the investigator that could interfere with the performance of scorad score result. 10. subjects who is lack of physical integrity of gastrointestinal tract, or malabsorption syndrome, or inability to take oral medication.

Keywords: probiotics lactobacillus paracasei gmnl-133 lactobacillus fermentum gm-090 atopic dermatitis asthma lactobacillus paracasei lactobacillus fermentum efficacy and safety
trial to evaluate the safety, tolerability, and immunogenicity of an investigational herpes zoster vaccine (z-1018) compared to shingrix® in healthy adult volunteers

Conditions: Shingles; Herpes Zoster; Vaccine-Preventable Diseases

Summary: this is a randomized, active-controlled, dose-escalation multi-center study of 2 doses (day 1 and week 8) of an investigational herpes zoster (hz) vaccine (z-1018), combining herpes zoster antigen- (ge) with a toll-like receptor 9 (tlr9) agonist adjuvant (cpg 1018) with and without alum in approximately 150 healthy volunteers 50 to 69 years of age (inclusive).


Eligibility criteria:
inclusion criteria: * male or female, 50 to 69 years of age * be in good health in the opinion of the investigator, based upon medical history, physical examination, and laboratory evaluation * must be able to comprehend and follow all required study procedures and be available for all visits scheduled in the study * seronegative for human immunodeficiency virus (hiv) exclusion criteria: * history of hz * previous vaccination against varicella or hz * if female of childbearing potential, is pregnant, breastfeeding, or planning a pregnancy * known history of hiv (hiv 1/2 antibodies) * has a history of sensitivity to any component of study vaccines * has received any blood products or immunoglobulin within 90 days prior to study injection, or is likely to require infusion of blood products during the study period * has received the following prior to the first injection: * 14 days: any non-live vaccine * 28 days: * any live vaccine, including a covid-19 vaccine * systemic corticosteroids (more than 3 consecutive days) or other immunomodulators or immune suppressive medication, with the exception of inhaled steroids * granulocyte or granulocyte-macrophage colony-stimulating factor * any other investigational medicinal agent, including a covid-19 vaccine * chronic administration of immunosuppressants or other immune-modifying drugs within 6 months prior to the first vaccine dose * is undergoing chemotherapy or expected to receive chemotherapy during the study period; has a diagnosis of cancer within the last 5 years other than squamous cell or basal cell carcinoma of the skin * history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study, interfere with the subject's participation for the full duration of the study, or is not in the best interest of the subject to participate, in the opinion of the treating investigator * history of autoimmune disease
long term function outcomes and pain in implant-based post-mastectomy breast reconstruction

Conditions: Post-mastectomy Breast Reconstruction

Summary: the objective of this proposal is to broadly assess patient physical functioning following breast reconstruction.


Eligibility criteria:
inclusion criteria: * female * at least 18 years of age * had a mastectomy for breast cancer or cancer prevention any time between 01/01/2010 and 06/30/2021. * has undergone breast reconstruction surgery with plastic surgery faculty at the washington university school of medicine division of plastic and reconstructive surgery. * able to understand and willing to sign an irb-approved written informed consent document. exclusion criteria: -known distant metastatic disease
clinical study of the presence of trichomonas tenax and entamoeba gingivalis in patients with periodontitis

Conditions: Periodontitis, Adult

Summary: the buccal cavity presents microorganismes whose the number and composition vary with oral hygiene and medical context (pathologies and associated drug therapies) of the patient. more than 1200 bacterial species have been identified, and among them, 400 are inhabitants of the sub-gingival biofilm. among all these microorganismes, only 20 species participate to the etiopathogenesis of periodontal diseases.some are recognised as major periodontopathogens other play unclear role in this pathology. they belong respectively to the red and orange complex of socransky et al. (1998). other microorganismes such as virures, yeasts and protozoans could potentially impact the emergence and development of periodontal diseases. the presence of protozoans in periodontitis have been investigated in this study.


Eligibility criteria:
inclusion criteria: * adults \> 18 years-old * consulting in periodontal department of chu, nancy * patient with moderate to severe periodontitis * at least 2 periodontal sites with ppd≥ 4mm and one healthy site * no scaling root planning in the last 6 months * patients insured under the french social security system exclusion criteria: * pregnant patients * patients with antibiotic therapy, and/or all medecines which could modify the buccal microbiota in the last 6 months * tooth with endodontic periapical lesion * patients having a scaling root planning in the last 6 months * patient with guardianship
clinical trial of meditation for cardiovascular disease in older black women

Conditions: Cardiovascular Diseases

Summary: the purpose of this study is to evaluate the effectiveness of meditation in preventing of atherosclerotic cardiovascular disease (cvd) in postmenopausal, older african american women.

older african american women suffer from disproportionately high rates of cardiovascular (cvd) morbidity and mortality compared to white americans. numerous controlled studies suggest that this disparity is associated with chronic psychosocial and environmental stress. research indicates that transcendental meditation (tm) may result in significant improvements in cvd risk factors in this high risk population. participants in this study will be randomly assigned to either active stress reduction with tm or health education control, both in addition to usual medical care, for 12 months. the primary outcome will be carotid artery atherosclerosis (imt) measured non-invasively by quantitative b-mode ultrasonography. secondary measures will include traditional cvd risk factors (blood pressure, serum glucose and insulin levels, obesity, and sedentary lifestyle), stress-related neurohormones (catecholamine metabolite and cortisol), psychosocial stress, and quality of life. the results of this trial will yield valuable new knowledge for the prevention of cvd through a cam intervention in high risk older african american women.

Eligibility criteria:
inclusion criteria: * african american, self-identified * coronary artery disease (cad/chd) defined by laboratory examination or documented clinical history of: a)myocardial infarction; b) coronary revascularization procedure--cabg, ptca; c) coronary angiography--at least one coronary artery with \>50% stenosis * informed consent * written permission of participant's referring physician

Keywords: cvd
monoamine contributions to neurocircuitry in eating disorders

Conditions: Eating Disorder

Summary: this study will use brain imaging technologies to measure several neurotransmitters (serotonin and dopamine) that contribute to our abilities to respond to reward or inhibit our impulses, and which are known to be altered in the brain of people with anorexia nervosa (an) and bulimia nervosa (bn). because palatable food stimulates dopamine secretion, we propose to use a challenge with brain imaging that will stimulate dopamine release which we hypothesize will generate anxiety rather than pleasure in an, and will help explain why an restrict eating in order to reduce anxiety. this study will help to understand the unique puzzling symptoms in eating disorders and contribute to finding better methods for identifying effective treatments for these often relapsing and sometimes chronic disorders.

alterations of serotonin (5-ht) and dopamine (da) activity may contribute to extremes of appetitive behaviours in anorexia nervosa (an) and bulimia nervosa (bn), through effects on inhibitory and reward neural pathways. to avoid the confounding effects of malnutrition, and because they have behaviours and neural circuit alterations relevant for this study, we will study 25 recovered (rec) restricting-type an, 25 rec bulimic-type an (an-bn), 25 rec bn, and 25 control women (cw). this 5 year study, of women 18 to 45 years old, will employ positron emission tomography (pet) imaging with radioligands for the 5-ht transporter (\[11c\]dasb) and da d2/d3 receptors (\[11c\]raclopride).

Eligibility criteria:
inclusion * history of diagnostic and statistical manual (dsm-iv) diagnosis of anorexia or bulimia. * an women have history of average body weight (abw) below 85% for height. * an-bn subjects have history of abw below 85% abw. * an-bn subjects have history of binging/purging behaviors during a period of low weight. * subjects must be right-handed. * subjects have been recovered for 12 months or more. exclusion * diagnosis of alcohol or drug abuse or dependence in the 3 months. * alcohol or substance use within 30 days. * current diagnosis of an axis i disorder. * organic brain syndromes, dementia, psychotic disorders, or mental retardation. * neurological or medical disorders such as seizure disorder, renal disease, diabetes, thyroid disease, ekg indicative of electrolyte imbalance * bn subjects whose purging methods were the use of laxatives, diuretics * use of psychoactive medication in the 3 months. * pregnancy or lactation. * tobacco use in the 3 months.
distinction between lung cancer and gynecological cancers by canine scent detection

Conditions: Lung Cancer; Breast Cancer; Ovarian Cancer

Summary: previous studies have shown that specially trained sniffer dogs are capable to discriminate breath samples of patients with lung cancer and healthy individuals. so far it is not known whether this differentiation is specific for lung cancer or just identifies any form of (solid) tumor. therefore, the dog's ability to differentiate between lung cancer, breast cancer and ovarian cancer is tested.


Eligibility criteria:
inclusion criteria: * histologically confirmed lung or breast or ovarian cancer exclusion criteria: * other cancers * previous medical intervention within the last 14 days before gathering of the breath sample

Keywords: breath sample analysis exhalation analysis volatile organic compounds screening lung cancer breast cancer ovarian cancer canine scent detection
evaluation of the effect of venous diameter measurement by ultrasonography on pain and withdrawal response

Conditions: Pain; Withdrawal

Summary: during general anesthesia, intravenous (iv) medications can disrupt the patient's comfort by causing a pain sensation or a withdrawal response in the heart. propofol and rocuronium are among the most common causes of this condition. in recent years, the use of ultrasonography (usg) in anesthesia has become widespread with the rapid advancement of technology. the use of the patient's head is a non invasive method. this study is aimed to evaluate whether the size of the venous diameter assessed by ultrasonography in our study is an effect on pain and withdrawal response after drug injections.

the study was conducted in patients who underwent surgical procedures under general anesthesia by obtaining consent from the adnan menderes university medical faculty ethics board and written consent from the patients and then being admitted to the asa i-ii age group 18-70 years of age. patients with peripheric vascular disease, vasculitis, rheumatologic disease, non-cooperative, under the age of 18 and over 70, asa iii and above, allergic to general anesthetic agents and refusing to participate in the study were excluded from the study.

Eligibility criteria:
inclusion criteria: 18- 70 years of asa (american society of anesthesiology) physical status i- ii who were to undergo various elective operations exclusion criteria: rheumatologic disease peripheric vascular disease vasculitis patients with chronic pain syndrome, patients with neurologic deficits, patients with thrombophlebitis, patients with difficult venous access, patients with allergy

Keywords: rocuronium propofol pain withdrawal venous diameter
interest of a weekly consultation by a medical electro radiology manipulator (merm) in addition to the follow-up by the radiotherapist to improve the collection of radio-induced toxicities in patients undergoing proton therapy

Conditions: Paramedical Consultation; Radiotherapy; Proton Therapy; Brain Tumor

Summary: to our knowledge, the investigators have not found any scientific article dealing with cooperation between radiation oncologists and medical radiation technologists in the context of monitoring patients undergoing radiotherapy. cooperation protocols between health professionals are in progress but concern mainly technical procedures (ultrasound, laserthermal sessions). this study aims to evaluate whether merms, after training by physicians, can monitor clinical signs (for usual well-described toxicities) during treatment via a dedicated consultation. this approach participates in the development of new professions and cooperation protocols between health professionals. this mission of accompaniment on a dedicated time would make it possible to develop the caring role of the medical electroradiology manipulator.


Eligibility criteria:
inclusion criteria: * patient \> 18 years; * patient with malignant or benign brain or upper aerodigestive tract (adt) tumor candidate for proton therapy; * who score \< 2 * mastery of the french language; * patient affiliated with a social security system; * signature of informed consent prior to any specific procedure related to the study. exclusion criteria: * patient with another cancer previously treated with radiation therapy; * simultaneous participation in a therapeutic clinical trial; * patient deprived of liberty or under guardianship; * any associated medical or psychological condition that may compromise the patient's ability to participate in the study * patient unable to undergo trial monitoring for geographical, social or psychopathological reasons.
effect study of modified transoesophageal echocardiography on cerebral embolization after cardiothoracic surgery

Conditions: Coronary Artery Atherosclerosis

Summary: patients undergoing cardiac surgery frequently develop neurologic complications, ranging from subtle cognitive changes to evident confusion, delirium, and stroke. this continuum of complications is commonly caused by embolization in the brain due to manipulation of atherosclerotic parts of the aorta ascendens (aa) during surgery. timely detection of aa atherosclerosis before surgery enables the surgeon to consider changes of the surgical plan, to reduce the risk of embolization and thus subsequent neurologic complications. various methods exist to visualize the aa to detect atherosclerosis. epiaortic ultrasound scanning has become the gold standard, but is seldom used as it interferes often with surgical plan and can only be used after sternotomy. transesophageal echocardiography (tee) is a widely used imaging method permitting evaluation of the aorta preoperatively, but assessment of distal aa is hampered by interposition of air-filled trachea between esophagus and aa. the a-view® (aortic-view) method, a modification of conventional tee using a fluidfilled balloon, overcomes this limitation. the safety and diagnostic accuracy of the a-view® have successfully been shown in previous studies. the hypothesis of this study is that the use of a-view will reduce cerebral embolization secondary to a change of surgical technique.


Eligibility criteria:
inclusion criteria: * isolated cabg * elective surgery * stroke risk index \<75(newman, '96) exclusion criteria: * other than isolated cabg * contra-indication for tee * contra-indication for a-view * contra-indication for mri

Keywords: atherosclerosis aorta a-view distal ascending aorta transoesophageal echocardiography cabg cerebral embolisation
effects of low fodmap diet on leaky gut

Conditions: Irritable Bowel Syndrome

Summary: the pathophysiology of irritable bowel syndrome (ibs) is multifactorial involving complex interplay of altered intestinal permeability, mucosal immune activation, visceral hypersensitivity and gut dysbiosis. although the exact triggers for these pathological changes in ibs are not clear but diet might play an important role. in fact, several studies have reported improvement in gastrointestinal symptoms on a diet low in fodmaps (lfd) in patients with ibs, specifically in diarrhea predominant ibs (ibs-d). however, the mechanism of action of lfd is not well understood.

we aim to evaluate the following in patients with ibs-d. the effect of lfd on colonic permeability. 2.the effect of lfd on abundance of colonic mucosal immune cells specifically t-cell and mast cell abundance 3.the effect of lfd on colonic mucosal microbiome

Eligibility criteria:
inclusion criteria: * aged 18-65 years at the time of screening * normal serum studies including serum tissue-transglutaminase antibodies, thyroid stimulating hormone levels, c-reactive protein, complete blood count since the onset of symptoms * normal stool studies including c diff testing, culture, ova and parasites since the onset of symptoms * ibs-sss score of ≥175 at the end of 7-day screening period exclusion criteria: * individuals already on a lfd or other dietary restriction such as gluten free diet within the past 6 months * individuals with any known food allergy or insulin-dependent diabetes * known history of celiac disease, inflammatory bowel disease or microscopic colitis * prior small bowel or colonic surgery or cholecystectomy * pregnant patients * antibiotics in the past 3 months * those who regularly use mast cell stabilizers or anti-histaminic or non-steroidal anti-inflammatory agents (nsaids) excluding daily baby aspirin or steroids or bile-acid binder.