Kornimate/medical-research-clean huggingface dataset:
erector spinae plan block for postoperative analgesia

Conditions: Postoperative Pain

Summary: laparoscopic cholecystectomy is a widely employed procedure in ambulatory surgery. pain after laparoscopic cholecystectomy arises significantly from port site incisions in the anterior abdominal wall. innervation of the anterior abdominal wall is segmentally supplied by pain afferents in the plane of fascia between transversus abdominis and the internal oblique muscles. opioids analgesia is used to control postoperative pain, but it carries the risk of increased nausea and vomiting, ileus and sedation that may delay hospital discharge. several techniques have been tried as.neuroaxial narcotics, intraperitoneal lavage of local anesthetic and transversus abdominis plan (tap) block and successfully reduced opioid use and improve postoperative analgesia. the ultrasound-guided erector spinae plan(esp) block is a recently described technique which produces reliable unilateral analgesia at thoraco-lumbar dermatomes. esp block carries the advantages of being simple, safe, easily recognizable by ultrasound, and a catheter can be threaded to extend the duration of analgesia. few case series reported the efficacy of (us)-guided esp blocks in reducing postoperative pain and opioids consumption. because of that, the investigators aimed to test the hypothesis that us-guided esp blocks can decrease opioid consumption during the first 24 h after of laparoscopic cholecystectomy in comparison with the conventional systemic analgesia.


Eligibility criteria:
inclusion criteria: * 60 asa i- ii adult patients * 20-60 years old * elective laparoscopic cholecystectomy * body mass index (bmi) less than 35 * port sites at or above thoracic t 10 dermatome exclusion criteria: * allergy to amino-amide local anesthetics * presence of coagulopathy * local skin infection at the needle puncture sites * preoperative chronic dependence upon opioid and nsaid medications * liver or renal insufficiency * history of psychiatric or neurological disease * deafness * previous open surgery that need the conversion of laparoscopic to open surgery or manipulations more than expected with more tissue trauma * american society of anesthesiologists (asa) above class ii

Keywords: erecror spinae plan block postoperative pain laparoscopic cholecystectomy
the use of statins for myocardial death prevention

Conditions: Myocardial Infarction

Summary: the administration of high dose hmg-coa reductase inhibitors (statins) to patients with acute st-elevation mi (hypoxia/ischemia) who are treated with primary pci (reoxygenation/ reperfusion) will protect their cardiomyocytes from death and thus preserve lv ejection fraction.


Eligibility criteria:
inclusion criteria: 1. patients suffering from acute st elevation resulting from myocardial infarction, killip classification 1 and 2 will be included at-random to either group. included subjects should be able to give their informed consent to participate in this study. exclusion criteria: 1. the impossibility to give the required informed consent. 2. known allergy to atorvastatin. 3. base line serum creatinine of 1.4 mg/dl. 4. killip classification 3 and 4. 5. persisting vomiting. 6. history of previous liver disease. 7. history of previous muscle disease or rabdomyolisis. 8. treated already with high dose atorvastatin 9. non compliance.

Keywords: acute st elevation myocardial infarction
covid-19 vaccine confidence among pregnant women and mothers

Conditions: Pregnancy Related; Mothers

Summary: the purpose of this study is to assess the level of vaccine confidence and influencers among pregnant women and mothers of school-aged children during the covid-19 pandemic.

the who has listed "vaccine hesitancy" as one of the top threats to global health. the covid-19 pandemic has triggered the need to vaccinate worldwide as soon as a safe and efficacious vaccine becomes available. however preliminary data show that, on average, only 50% to 66% of us adults would be willing to receive covid-19 vaccination when it becomes available, a percentage lower than what is required for herd immunity to control the pandemic. furthermore, there is a pressing need to vaccinate children to reopen schools and keeping them safe, as well as to immunize pregnant women through vaccination programs since they constitute a vulnerable population. vaccine confidence among pregnant women and mothers of school-aged children during the period of covid-19 pandemic is unknown, leading to an important gap of knowledge that may hinder the upcoming global covid-19 vaccination scale-up effort. it is therefore of critical importance to assess the level of vaccine confidence and influencers among pregnant women and mothers of school-aged children during the covid-19 pandemic. the international nature of the proposed survey will allow the evaluation of vaccine confidence and its influencers among pregnant women and mothers of school-aged children on a global level. therefore, social and geographic characteristics from different countries and cultures will be available for comparison. the resulting knowledge will be relevant to a large percentage of the world's population. any country in the world can participate.

Eligibility criteria:
inclusion criteria: * pregnant women or women who have at least one child younger than 18 years of age. able to give electronic informed consent exclusion criteria: * \<18 years of age
hemodynamics during induction of general anesthesia with high and low propofol dose.

Conditions: Hemodynamics Instability; Anesthesia, General; Anesthesia, Intravenous

Summary: the study objective is to examine if a high propofol dose is non-inferior to a low dose in respect to hemodynamic stability in healthy patients during induction of general anesthesia with propofol and remifentanil.

typically, one or more adjuvant medications are administered to supplement induction of general anesthesia. when combining anesthetic drugs, the hypnotic effects are often synergistic. propofol is associated with hypotension and bradycardia and used together with remifentanil or sedative agents it may give synergistic or additive sedative and hemodynamic effects. claeys (1988) and fairfield (1991) examined the cardiovascular effects of propofol 2-2.5 mg/kg induction dose and found significant reductions i sbp and svr and small changes in co, sv and hr. de wit (2016) examined hemodynamic changes in different steady state propofol serum concentrations, and found a dose dependent sbp reduction, reduction in resistance of arterial and systemic circulation and a reduction in mean systemic filling pressures (msfp) indicative of a reduction in "stressed volumes". the effective dose (ed) 95% for loss of consciousness for propofol was determined to 1.75 mg/kg when used alone, and 1.38 mg/kg when used together with remifentanil 0.25 microg/kg/min (total induction dose 1.75 microg/kg remifentanil) in a study by koh et al. we want to examine the hemodynamic effects of giving a low (1.4 mg/kg) vs a high (2.4 mg/kg) propofol dose combined with a moderate remifentanil dose (about 1.5 microg/kg).

Eligibility criteria:
inclusion criteria: * healthy women * age 18-50 years * gynecological procedures * general anesthesia exclusion criteria: * pre-existing hypertension * diabetes for several years * ischemic heart disease * cerebrovascular disease * heart valve disease * verified cardiac arrhythmia * anaemia * kidney or hepatic disease * hypersensitivity for soya, eggs or peanuts * pregnancy * poor health state * illicit substance use * bmi \ 35 kg/m2 * sbp \>150 mmhg * hr \>100 beats/min

Keywords: cardiac output (co) systolic blood pressure (sbp) systemic vascular resistance (svr) heart rate (hr) stroke volume (sv) lithium dilutional cardiac output (lidco) minimal invasive hemodynamic monitor propofol propolipid
efficacy classification prediction of the effects of acupuncture on abdominal pain in patients with crohn's disease

Conditions: Crohn Disease

Summary: machine learning algorithms are applied to discover gut flora markers that predict the clinical efficacy of acupuncture, so as to screen the appropriate population for acupuncture and optimise the allocation of healthcare resources.

crohn's disease is an intestinal inflammatory disease,causing abdominal pain, diarrhea and other symptoms.the intestinal flora disorder is closely related to the occurrence and development of crohn's disease. acupuncture can induce remission of crohn's disease during mild to moderate active period, improve clinical symptoms such as abdominal pain. acupuncture can affect the gut microbiota. the aim of this study was to apply gut microbiological data and clinical data from subjects at baseline to predict the clinical efficacy of acupuncture by machine learning algorithms, and to classify patients as effective/ineffective in order to screen for suitable subjects for acupuncture.

Eligibility criteria:
inclusion criteria: 1. aged 18-75, no gender limit; 2. disease in mild and moderate active period: 150≤cdai\<450 and meet at least one of the following: serum c-reactive protein level≥5mg/l, fecal calprotectin concentration≥250μg/g or endoscopic examination shows ulcers. remission period: cdai \<150 and meet at least one of the following: serum c-reactive protein level\<5 mg/l, fecal calprotectin concentration \<250μg/g or endoscopic examination shows no ulcer; 3. patients were not taking medication or were only taking one or more of the following drugs: mesalazine (≤4g/d and mesalazine was used for at least 1 month), prednisone (≤15mg/d and prednisone was used for at least 1 month) and / or azathioprine (≤1mg/kg/d and azathioprine was used for at least 3 month); 4. those who have not used biologics within 3 months before entering the study; 5. those who have never experienced acupuncture; 6. those who understand and agree to participate in this study and sign the informed consent form. exclusion criteria: 1. patients who are recently pregnant or in pregnancy or lactation; 2. patients with serious organic diseases; 3. patients diagnosed as psychosis; 4. patients who suffer from multiple diseases and need to take other drugs for a long time, and may affect the observation of the efficacy of this trial; 5. severe skin diseases (such as erythema nodosum, pyoderma gangrenosum, etc.), eye diseases (such as iritis, uveitis, etc.), thromboembolic diseases and other serious extraintestinal manifestations; 6. there are serious intestinal fistula, abdominal abscess, intestinal stenosis and obstruction, perianal abscess, gastrointestinal hemorrhage, intestinal perforation and other complications; 7. patients with short bowel syndrome who have undergone abdominal or gastrointestinal surgery in the past half a year; 8. there are skin diseases or defects in the selected area of acupuncture and moxibustion that cannot be performed.

Keywords: crohn disease intestinal flora abdominal pain machine learning
gut microbiome based analysis of high protein high fat diet

Conditions: Obesity

Summary: the aim of this study was to determine body mass reduction and microbiota composition change after the weight loss diet (50 % fat, 25 % proteins and 25 % carbohydrates).

for high fat group a total of 19 overweight/obese participants (14 females, 5 males, aged 25 to 43) with bmi of 28.9-44.4 kg/m2 were assigned to low-calorie low-carbohydrate high-fat weight loss diet for 4 weeks. as a control group, 58 subjects (39 females, 20 males, aged 24 to 55 years) were recruited and divided into 3 groups based on bmi: 18-25, 25-30, 30-39 kg/m2 (n=33, n=16, n=9, respectively). inclusion criteria for participants included no previous history of gastrointestinal (gi) disease, no reported antibiotic use in preceding 3 months, or taking any medication known to alter bowel motility, no history of food allergies and not taking medications. before the study all participants were informed about the study and participants were signed a written consent. at day 0 baseline samples and data were collected (faecal sample, bristol score and bowel habits, food diary about the period of at least three days before faecal sampling, body weight). after collection of baseline samples subjects in the high fat group started diet plan for 4 weeks while control group contiunued their habitual diet. after the 4 week intervention period samples and data were collected again (faecal sample, bristol score and bowel habits, food diary about the period of at least three days before faecal sampling, body weight).

Eligibility criteria:
inclusion criteria for obese group: * bmi \> 30 g/m2 exclusion criteria: * antibiotic treatment within last three months; * food restrictions due to allergies, any kind of food intolerance, veganism/vegetarianism or other extremes in food consumption practices; * chronic illnesses; * current pregnancy or breastfeeding * travel to subtropical or tropical regions within one month before the study.

Keywords: microbiome ribosomal sequencing obesity bifidobacteria collinsella
implementation of physical exercise at the workplace (irma08) - healthcare workers

Conditions: Musculoskeletal Disorders

Summary: the prevalence and consequences of musculoskeletal pain is considerable among healthcare workers, allegedly due to high physical work demands of healthcare work. previous studies have shown promising results of physical exercise for relieving pain among different occupational groups, but the question remains whether such physical exercise should be performed at the workplace or in the private sphere at home. performing physical exercise at the workplace together with colleagues may be more motivating for some employees and thus increase compliance. on the other hand, physical exercise at the workplace may be costly for the employers in terms of time spend. thus, relevant ground exists to compare the efficacy of workplace- versus home-based training on musculoskeletal pain. this study investigates the effect of workplace-based versus home-based physical exercise on musculoskeletal pain among healthcare workers. the main hypothesis is that physical exercise at the workplace for 10 weeks compared with physical exercise at home results in reduced musculoskeletal pain among healthcare workers.


Eligibility criteria:
inclusion criteria: * healthcare worker * female * age 18-67 exclusion criteria: * life threatening disease * pregnancy
a phase 1 study to evaluate the immunogenicity and safety of a pandemic avian influenza vaccine in adults

Conditions: Influenza

Summary: recombinant hemagglutinin has been shown to induce protective neutralising antibodies against avian influenza virus but is relatively non-immunogenic. an ideal pandemic avian influenza influenza vaccine would combine hemagglutinin antigen with an appropriate adjuvant to increase its immunogenicity. this phase 1 study will collect preliminary human safety and efficacy data on combined formulations of recombinant hemagglutinin with advax adjuvant formulations administered by intramuscular injection

this is a study to test new vaccine formulations against pandemic avian influenza ("bird flu"). bird flu is a potentially deadly disease that is caused by influenza virus from birds. it is not the same as the common seasonal flu for which there is a seasonal vaccine released around march each year. to date, bird flu due to the h5n1 strain of influenza virus has infected over 500 people mainly in asia resulting in death in more than half the cases. more recently there has been an outbreak of another bird flu virus in china known as h9n7 that is also highly lethal when it infects humans. vaccination is the single most effective measure to prevent infection from bird flu viruses such as h5n1 or h9n7 should such a pandemic occur. in the event of a major bird flu pandemic outbreak, vaccine supplies are likely to be very limited, as there is not currently sufficient manufacturing capacity to provide enough vaccine quickly for the whole population. research is needed on how to make the pandemic flu vaccine more effective but also how to stretch vaccine supplies using a strategy called 'antigen-sparing'. this can potentially be achieved by using an important ingredient called an 'adjuvant'. adjuvants act by stimulating the immune system to make vaccines more effective. this study will test advax adjuvants which are based on delta inulin in combination with recombinant hemagglutinin from the h5n1 influenza virus serotype.

Eligibility criteria:
inclusion criteria: * ambulatory males or females aged 18 years and over * able to provide written informed consent * willing and able to comply with the protocol for the duration of the study. * not planning to have seasonal influenza vaccine within 2 months from the time of the first trial immunization exclusion criteria: * pregnant or lactating women. * women of childbearing potential unless using a reliable and appropriate contraceptive method. * receipt of another investigational agent within 28 days preceding initiation of treatment. * any other serious medical, social or mental condition which, in the opinion of the investigator, would be detrimental to the subjects or the study.
propensity to hospitalize patients from the ed in european centers.

Conditions: Emergency Medicine

Summary: the peer-to-peer comparison means center-to-center comparison, which requires adjusting for possible differences among centers to be fair and convincing. the first step to reach this goal is to develop a predictive model that accurately estimates each patient's probability of being admitted, starting from clinical conditions and boundary variables. such a model would make it possible to calculate, for each ed, the expected hospitalization rate; that is, the hospitalization rate that would have been observed if the ed had behaved like the average of the eds that provided the data to build the model itself. comparing the observed hospitalization rate in the single ed with the expected rate derived from the model provides a rigorous method of comparing the department with the average performance, taking into account the characteristics of the patients treated and the conditions under which the ed operated. in other words, the predictive model represents the benchmark against which each ed is evaluated.


Eligibility criteria:
inclusion criteria: * adult * arrived at emergency department between 1 january 2021 and 31 december 2023 exclusion criteria: * none
myl-1402o compared with avastin®, in patients with stage iv nsnsclc

Conditions: NSCLC Stage IV

Summary: assess the efficacy and safety of myl-1402o compared with avastin®, in the first-line treatment of patients with stage iv non-squamous non-small cell lung cancer

myl-1402o is a monoclonal antibody currently being developed by mylan gmbh, as a proposed biosimilar to european union and us licensed avastin (hereafter referred to as avastin), which is approved as first line treatment in combination with carboplatin and paclitaxel (cp) for patients with stage iv unresectable, recurrent or metastatic nsnsclc. this randomized equivalence study is designed to meet the global regulatory requirement for approval of a biosimilar product. for this study, both myl-1402o and avastin are considered investigational medicinal products (imp).

Eligibility criteria:
key inclusion criteria: 1. written and signed informed consent 2. male or female at least 18 years of age with documented imaging diagnosis of stage iv unresectable, recurrent or metastatic nsnsclc with at least one measurable lesion as defined by recist 1.1 3. documented histologic or cytologic diagnosis of advanced nsnsclc with negative or unknown sensitizing epidermal growth factor receptor (egfr) mutation, and negative or unknown echinoderm microtubule-associated protein like 4 anaplastic lymphoma kinase (eml4 alk) rearrangement. 4. eastern cooperative oncology group (ecog) performance status 0 or 1 5. has not received any prior systemic therapy for first-line treatment of advanced lung cancer, except adjuvant chemotherapy, and remained disease-free for at least 12 months from time of surgery, and at least 6 months from last dose of chemotherapy. 6. treated and stable brain metastasis. key exclusion criteria: 1. documented squamous nsclc or small cell type or large cell neuroendocrine histology 2. history of significant hemoptysis, central tumors with proximity to large vessels and tumor with cavitation 3. received prior treatment with paclitaxel, bevacizumab or anthracycline or had known hypersensitivity to any of these components. 4. recent significant cardiac condition or vascular event or inadequately controlled hypertension. 5. on anticoagulant therapy not considered stable 6. risk of hemorrhage in the central nervous system 7. recent history of surgery, nonhealing wound, active ulcer, or untreated bone fracture. 8. history of gastrointestinal fistula, perforation, or abscess.
couplelinks.ca - an online intervention for couples affected by breast cancer

Conditions: Distress; Breast Cancer; Depression; Anxiety

Summary: women diagnosed with breast cancer (bc) at or before the age of 50 experience more distress and poorer quality of life than women diagnosed later in life. although adequate spousal support is a protective factor for women with bc, spouses are often unprepared to handle the myriad practical and emotional demands posed by the illness. furthermore, despite the growing number of recommendations for couple interventions in relation to bc, traditional counselling approaches may fail to meet the needs of young couples who have unique concerns and tight constraints on their time. the proposed project addresses the void in the psycho-social support available to young couples via an innovative, online psychoeducational intervention tailored specifically to their needs.

couplelinks.ca is a custom-designed website offering a professionally facilitated, couple-centred intervention that entails informational, experiential, and interactive components. six dyadic learning modules (dlm) form the core of the program and are undertaken on a weekly basis. a funded pilot study examining the feasibility and benefit of couplelinks.ca utilized a non-randomized, pre-post test design to assess the process and outcomes of the intervention. qualitative feedback also informed the evaluation. preliminary findings were promising and provided justification for further evaluation of the program's effectiveness. the current study is the next logical step: a larger-scale phase iii study to determine whether this bc-specific, relationship-enhancement program leads to improved relationship and psychological outcomes for young couples affected by bc. it is a randomized controlled trial (rct) comparing level of distress and dyadic adjustment in couples who have participated in the couplelinks.ca educational program to those who have not participated and were instead put on a wait-list for participation.

Eligibility criteria:
inclusion criteria: * couples where woman has received a diagnosis of nonmetastatic breast carcinoma; * diagnosis was within the last 36 months; * woman is age less than or equal to 50 at age of diagnosis; * completed or are nearing the end of active treatment; * couples must be in a committed, heterosexual relationship; * fluent in english with the ability to read and write in english. exclusion criteria: * non-heterosexual couples; * women older than 50; * previous diagnosis of moderate to severe psychological problems that may interfere with capacity to benefit from the intervention; * couples who plan to participate in couple counselling during the 5-month study duration.

Keywords: breast neoplasm breast cancer behavioral intervention online support relationship distress dyadic coping
bimatoprost for the treatment of eyebrow hypotrichosis

Conditions: Eyebrow Hypotrichosis

Summary: this study will evaluate the safety and efficacy of bimatoprost solution compared with vehicle in the treatment of eyebrow hypotrichosis (inadequate eyebrows).


Eligibility criteria:
inclusion criteria: -adult participants with eyebrow hypotrichosis (inadequate eyebrow growth). exclusion criteria: * patients with disease, infection, or abnormality of the eyebrow area * patients with permanent eyebrow loss due to over-grooming