Kornimate/medical-research-clean huggingface dataset:
concussion treatment after combat trauma (contact)

Conditions: Traumatic Brain Injury

Summary: this study compares the effects of individualized scheduled telephone support (ists) and usual care (uc) for service members with mild traumatic brain injury (mtbi). a total of 400 service members will participate in this study. ists is a telephone intervention that provides injury-related education, training in problem solving, and focused behavioral strategies for problems (e.g. anxiety, depression) that commonly co-occur with mtbi. ists also includes access to usual care and web-based and printed educational material. the 12 phone calls included in ists will be administered over a 6-month period. uc is the usual care provided to service members attending the traumatic brain injury (tbi) clinics at madigan army medical center and womack army medical center, plus web-based education and 12 mailings of educational materials over a 6-month period. subjects will complete major assessments at study entry and then 6 months and 12 months later. the primary aim of the study is to compare the effects of ists and uc on post-concussive symptoms and emotional distress at the 6-month assessment. the investigators predict that participants who receive ists will report lower levels of post-concussive symptoms and emotional distress at the 6-month assessment. secondary aims include comparing the longer term effects of ists and uc at the 12-month assessment, as well as comparing their effects on other outcomes such as post-traumatic stress symptoms, quality of life, resilience, and work activity.


Eligibility criteria:
inclusion criteria: 1. active military or national guard/reserve status 2. enrollment within 2 years of return from operation enduring freedom/operation iraqi freedom (oef/oif) theater and subsequent operations. 3. positive response to screening at post-deployment examination and positive response to questions 1,2, or 6 on the "2 + 10 traumatic brain injury (tbi) screening questionnaire" or positive response to questions 1c, 4,5, or 6 on the military acute concussion evaluation (which corresponds to the critical sections of the centers for disease control operational definition of mild traumatic brain injury (mtbi)) 4. has access to a telephone. exclusion criteria: 1. moderate or severe tbi (glasgow coma scale \< 13) requiring hospitalization 2. active psychotic disorder (including schizophrenia and schizoaffective disorder), severe depression with active suicidal ideation at tbi clinic visit, or current bipolar disorder by history. 3. enrollment into intensive treatment at tbi programs at madigan or womack army medical center

Keywords: mild traumatic brain injury telephone counseling
program on surgical control of hyperlipidemias (posch)

Conditions: Cardiovascular Diseases; Coronary Disease; Heart Diseases; Myocardial Infarction; Myocardial Ischemia

Summary: to determine whether a profound reduction in serum cholesterol level, induced and maintained by partial ileal bypass, would prevent a second heart attack among men and women who had one myocardial infarction and whose blood cholesterol could not be reduced sufficiently by diet.

background: the correlative evidence linking elevated cholesterol to increased risk of cardiovascular disease is incontrovertible. animal studies have shown that significant reductions in disease in humans may be forthcoming if blood lipids are reduced from elevated levels. beginning in the 1960s, some patients had undergone a surgical bypass procedure for hyperlipidemia. patients were selected for surgery after dietary management had been carried out for three years. the average serum cholesterol concentrations decreased markedly and the decrease was sustained. this grant-supported clinical trial attempted to determine the effect on cardiovascular morbidity and mortality of the partial ileal bypass in patients who had suffered a myocardial infarction within the previous 5 years and who had serum cholesterol over 220 mg deciliter (200 mg if ldl cholesterol was over l40 mg). design narrative: randomized, non-blind, fixed sample study with a control group and an experimental group of equal size. the experimental group received a partial ileal bypass and diet therapy to reduce serum cholesterol and triglycerides. the control group was given conventional medical therapy exclusive of cholesterol-lowering drugs. the primary endpoint was death due to any cause. secondary endpoints included death due to atherosclerosis and morbidity from recurrent myocardial infarction, unstable angina, cerebrovascular accident. other secondary endpoints included coronary artery bypass surgery, percutaneous transluminal coronary angioplasty, cardiac transplantation, and peripheral vascular surgery. beginning in january 1993, long-term morbidity and mortality follow-up are continuing through december 1997 under grant support (r01hl49522). follow-up includes tracking morbidity and mortality by an annual telephone survey and review of patient records, including death and autopsy results. in addition, mortality and morbidity will be correlated with lipid changes and existing arteriographic results. the long-term course of control patients treated with the aha phase ii diet counseling will be assessed and the long-term side effects of partial ileal bypass will be evaluated.

Eligibility criteria:
men and women, ages 30 to 64. had one myocardial infarction. had hyperlipoproteinemia.
is prophylactic antibiotics necessary in otherwise healthy adult patients undergoing ureteroscopic procedures for ureteral stones?

Conditions: Ureteral Stones

Summary: the present study aims to investigate the relative efficacy, safety and risk of a single-dose prophylaxis in otherwise healthy adult patients undergoing ureteroscopic procedures for ureteral stones.


Eligibility criteria:
inclusion criteria: * 100 otherwise healthy adult patients. * aged from 20 to 65 years. * undergoing ureteroscopic procedures for ureteral stones. exclusion criteria: * have the urine road the infection before the surgical operation, the surgical operation once took antibiotics the first 2 week. * pregnant or the women been breast feeding.

Keywords: prophylactic antibiotics, urinary tract infection.
effect of selective inos inhibition during human endotoxemia

Conditions: Endotoxemia

Summary: sepsis or endotoxemia is manifested by hypotension, resistance to vasopressors, myocardial depression,and altered organ blood flow distribution. the mechanisms underlying the cardiovascular dysfunction during sepsis are complex; however, they are partially mediated by an uncontrolled production of no by inducible no synthase (inos).control subjects received 2 ng/kg e. coli endotoxin, whereas the active intervention group received endotoxin in the presence of selective inos-inhibitor aminoguanidine. hemodynamics, vascular responses to norepinephrine, acetylcholine and sodium nitroprusside, as well as circulating cytokines and other mediators of inflammation were measured. we tested the hypothesis that inhibition of no-synthesis prevented the lps-mediated insensitivity to noradrenalin and endothelial-dependent vasorelaxation. furthermore, we tested whether no participates in occurrence of the endotoxin tolerance in humans by using the inos inhibitor aminoguanidine on healthy volunteers with endotoxemia. at 0; 2 and 4 hours after the lps challenge whole blood was stimulated with five tlr agonists in vitro and pro- and anti-inflammatory cytokines were measured.


Eligibility criteria:
inclusion criteria: * healthy volunteers exclusion criteria: * tendency towards fainting * alcohol abuse * nicotine abuse * drugs abuse

Keywords: endotoxemia aminoguanidine
optimization of advanced mr sequences

Conditions: Neurosciences; MRI; Brain Tumor; Mental Disorders; Stroke

Summary: this monocentric methodological study aims at optimizing advanced mr sequences for image quality (reduced artefacts, signal to noise ratio, acquisition time, stability of quantitative measurements) on a new mr unit dedicated to research in clinical and cognitive neuroscience.

primary goal : optimization of mr protocols and validation of acquisition parameters of advanced mr sequences on healthy volunteers or patients on a new 3t mr unit dedicated to research in neurosciences. secondary goals 1. perform acquisitions to validate the feasibility of research mr protocols (pilot subjects) 2. reproducibility studies

Eligibility criteria:
inclusion criteria: * 18 ans * covered by social security * for women in age of procreation, under efficient contraception * written consent exclusion criteria: * any mr contraindication * claustrophobia * pregnancy * under judiciary protection
comparison of extraperitoneal and intraperitoneal cesarean technique

Conditions: Postpartum Fever; Ileus; Hemorrhage; Pain

Summary: cesarean section will performed via intraperitoneally and extraperitoneally. during postoperative period pain, need for analgesia, respiratory function tests, ileus, bowel movement, discharged time will be compared.

investigators will compared results intra and extraperitoneal cesarean section. two groups will determine according to random numbers table. after operations, blood count, c reactive proteins, postoperative temperature, need for analgesia, ileus, bowel movement, mobilization time will compare by blind physician. abdominal, shoulder and incisional pain at postoperative 0, 6, 12, 18, 24, 30 hours will compared by use visual analog score. neonatal results and complications also will compare. investigators and participants will be blind regarding technique.

Eligibility criteria:
inclusion criteria: * cesarean section for any reasons exclusion criteria: * involuntary

Keywords: forced expiratory volume in 1 second forced expiratory vital capacity peak expiratory flow
internet-based intervention for occupational stress among medical professionals

Conditions: Stress, Psychological, Occupational; Burnout, Professional

Summary: the aim of this study is to assess the efficacy of internet intervention for reduction of occupational stress and its negative consequences (job burnout, depression) among medical professionals through the enhancement of the resources that are critical for coping with stress: self-efficacy and perceived social support.

medical professionals are at high risk for job stress and burnout. research show that the negative effects of stress can be reduced through strengthening personal resources such as self-efficacy and perceived social support. in line with cultivation and enabling hypotheses (schwarzer \& knoll, 2007; benight \& bandura, 2004) either self-efficacy cultivates perceived support, or rather perceived support enables self-efficacy. this study aims at testing both hypotheses in experimental design by applying them as a theoretical framework for the med-stress: evidence-based, cbt-framed internet intervention to foster resource accumulation among medical professionals. the effectiveness of intervention will be tested in a four-arm randomized controlled trial comparing the effects of: 1) self-efficacy and perceived support sequential enhancement (cultivation hypothesis), 2) perceived support and self-efficacy sequential enhancement (enabling hypothesis), 3) only self-efficacy, and 4) only social support enhancement (controls). primary outcomes are job stress and burnout, secondary outcomes include work engagement, depression, and secondary traumatic stress. self-efficacy and perceived support are expected to mediate the relationships between condition assignment and outcomes. assessments include baseline (t1), three- or six-weeks post-test (depending on the condition, t2), as well as six- and twelve-months follow-ups (t3, t4). intervention effect sizes and between-groups comparisons at post-test and follow-ups will be calculated. this study will contribute to the findings on the role of personal resources in the development of job stress and burnout by demonstrating the cultivation vs enabling effects of self-efficacy and perceived social support.

Eligibility criteria:
inclusion criteria: * age of at least 18 years * professionally active medical providers * internet connection exclusion criteria: * no access to a device with internet connection

Keywords: e-mental health stress burnout self-efficacy social support
positron emission tomography (pet) using hormone receptor ligands in breast cancer

Conditions: Breast Cancer

Summary: the purpose of this study is to find a way to learn the hormone receptor status of a tumor before surgery is done. by testing for the hormone receptor proteins, doctors can find out if the breast cancer uses hormones to grow. this is important since the hormone receptor status of a tumor helps doctors decide if extra treatment like chemotherapy or pills are needed.


Eligibility criteria:
inclusion criteria: * male and female patients * aged 18 or older at the time of breast cancer diagnosis * patients with invasive breast cancer at least 1 cm in size. patients who have had a prior surgical excision are eligible provided there is a residual of at least a 1 cm area suspected on imaging studies. * histopathologic review at mskcc confirming diagnosis of invasive breast cancer (ductal, lobular, or inflammatory breast cancer). * patients who are operative candidates. patient will have surgery to include either mastectomy or lumpectomy. radiologic assisted excisions such as needle localization are also eligible. * patients with bilateral breast cancer are eligible. * patients with metastatic cancer, provided they need surgical biopsy. * patients who are undergoing sentinel node mapping (day before or sameday mapping). * patient must sign informed consent. exclusion criteria: * previous or concurrent malignancy (except basal and squamous skin cancer and stage 0 cervical cancer) * patients who are pregnant or nursing * patients unable to tolerate pet or pet/ct * patients with known active infection, autoimmune or inflammatory disease such as sarcoidosis, and rheumatoid arthritis. * patients with non invasive breast cancer such as dcis. * patients who have received prior radiation therapy to the affected breast. * patients who have received prior chemotherapy, including neoadjuvant chemotherapy or hormonal therapy for breast cancer. * patients living in a residential care or correctional facility.

Keywords: pet imaging invasive breast cancer
varying the energy density and portion size of the main course after a first-course salad

Conditions: Obesity

Summary: the purpose of this research is to determine whether varying the energy density and portion size of the main course will affect meal energy intake after consumption of a first course that has previously been shown to enhance satiety. it is hypothesized that increasing either the energy density or portion size of the main course will increase meal energy intake after consumption of the first course. it is also hypothesized that compared to when a first course is consumed, not consuming a first course will increase meal energy intake.


Eligibility criteria:
inclusion criteria: * adults from penn state and the surrounding community exclusion criteria: * currently dieting * food allergies

Keywords: feeding behavior
ologen(oculusgen)-glaucoma and pterygium historical control study in china shanghai sixth people's hospital

Conditions: Glaucomas; Pterygium

Summary: the purpose of this study is to determine whether the ologen (oculusgen) collagen matrix are effective and safe to implant as an aid of glaucoma surgery and pterygium excision surgery.

ologen (oculusgen) collagen matrix is a porous, scaffold matrix. it is to be implanted on the top of the scleral flap and beneath the conjunctiva and tenon's capsule at the end of trabeculectomy. the pores in the scaffold matrix range from 20 to 200µm, a size that is suitable for fibroblasts to grow randomly, through the body of the matrix without causing scarring. the space occupied by the collagen matrix scaffold creates room for the development of a filtration bleb. immediately after implantation, the collagen matrix is absorbed with the aqueous humor that bring a certain pressure press on the top of scleral flap which makes the dynamic balance for the aqueous system to keep the iop in the right side. the collagen matrix is bio-degraded within 90 days and will leave a physiologic space for the filtration bleb to facilitate control of intraocular pressure (iop).

Eligibility criteria:
inclusion criteria: * age 18 years or over * patient able to cooperate with study procedures and able to perform tests reliably * patient willing to sign informed consent * patient able and willing to complete postoperative follow-up requirements * glaucoma：one/both eyes are affected by glaucoma * pterygium： patient with pterygium exclusion criteria: * known allergic reactions to collagen

Keywords: glaucoma pterygium collagen matrix oculusgen trabeculectomy anti scarring pterygium recurrence tissue engineering ologen aeon astron
a study to evaluate the safety and effectiveness of alks 2680 in subjects with idiopathic hypersomnia

Conditions: Idiopathic Hypersomnia

Summary: the purpose of this study is to measure the safety and decrease in daytime sleepiness in subjects with idiopathic hypersomnia when taking alks 2680 tablets compared with placebo tablets


Eligibility criteria:
inclusion criteria: * is willing and able, in the opinion of the investigator, to understand and comply with protocol requirements, including: lifestyle considerations and restrictions, adherence to contraception guidance, adherence to actigraphy and diary requirements, if receiving treatment for osa, adherence to primary osa therapy over the 30 days prior to visit 1, and throughout the study, including during overnight visits. * meets the diagnostic criteria of idiopathic hypersomnia according to icsd-3-tr guidelines, confirmed by the diagnostic evaluations (psg/mslt/actigraphy) within the previous 10 years exclusion criteria: * has another comorbid sleep disorder or condition that may influence the sleep-wake cycle * has a history or presence at visit 1 of other clinically significant (treated or untreated) illness, disease, abnormality, or surgical procedure that, in the opinion of the investigator, might compromise subject safety, interfere with any study assessment, or affect the subject's ability to complete the study * is currently enrolled in another clinical study or used any investigational drug or device within 30 days prior to visit 1 * is currently pregnant, breastfeeding, or is planning to become pregnant during the study

Keywords: idiopathic hypersomnia ih sleep sleep disorder orexin-2 receptor agonist excessive daytime sleepiness
study of the expression of heat shock proteins in populations of b lymphocytes in human tonsils

Conditions: Tonsillectomy

Summary: it has recently been shown that various hsps are strongly expressed in b lymphomas. indeed, hsp90 stabilizes the protein bcl-6 in diffuse large-cell b lymphomas. pharmacological inhibition of hsp90 in vitro induced apoptosis in lymphoma cells (cerchietti et al. nat. medicine, 2009, 1369-1376). in addition, hsp110 is strongly expressed in non-hodgkin lymphomas, and targeting this hsp at the cell surface using specific antibodies could constitute a future therapy (zappasodi et al. blood, 2011, 4421-4430). despite the importance of these proteins in the development of lymphomas, their expression and their role in the activation of normal b lymphocytes and the normal development of germinal centres is not known. the expression of heat shock proteins should vary among the different b lymphocyte populations present in the tonsils (naïve b cells, memory b cells, germinal centre b cells). the aim of this study is to establish an expression profile for heat shock proteins in populations of b lymphocytes in human tonsils


Eligibility criteria:
inclusion criteria: * persons who have provided oral consent * tonsillectomy in children or adults exclusion criteria: * persons without national health insurance cover * adults under guardianship * pregnant or breast-feeding women * persons with positive hiv or hcv serology
oshadi d and oshadi r in combination with docetaxel, as 2nd line therapy for metastatic non small cell lung cancer

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: the study will be a prospective open-label single-center study in previously treated patients with non small cell lung cancer (nsclc). treatment efficacy and safety of the combination of oshadi d and oshadi r with docetaxel will be will be evaluated. patients will receive docetaxel in combination with oshadi d and oshadi r. patient will be evaluated throughout the study for safety and tolerance to multiple dose regimens of oshadi d and oshadi r. ct or mri imaging will be performed prior to treatment initiation and at the end of every 3 docetaxel cycles (12 weeks). in case of disease progression, dose augmentation will be considered or subsequent therapy.


Eligibility criteria:
inclusion criteria: * locally advanced or metastatic nsclc (iiib-iv) * failure of first line anti-cancer therapy (either radiological documentation of disease progression or due to toxicity) in advanced disease or subsequent relapse of disease following first line therapy * man or woman 21 years and above * adequate performance status (ecog 0, and 1) * patient must have adequate organ function * written informed consent * females of childbearing potential and males must be willing to use an effective method of contraception (hormonal or barrier method of birth control; abstinence) from the time consent is signed until 6 weeks after treatment discontinuation. * females of childbearing potential must have a negative pregnancy test within 7 days prior to being registered for protocol therapy. exclusion criteria: * any treatment with investigational agent within 10 days prior to registration for protocol therapy. * cerebrovascular accident, transient ischemic attack or myocardial infarction within 3 months prior to registration for protocol therapy. * evidence of pulmonary embolism within 3 months prior to registration for protocol therapy. * any history of hematologic malignancies. * patient with known positive hiv serology at screening. * female patient who are breastfeeding or have a positive pregnancy test at screening or at any time during the study. * uncontrolled hypertension (\>160/100 mm hg despite optimal medical therapy). * evidence of ongoing cardiac dysrhythmias of nci ctcae (common toxicity criteria for adverse effects) version 3.0 grade 2. * patients in whom radiation or surgery is indicated * significant swallowing disorders. * small bowel surgery. * suspicion of absorption disruption as a result of abdominal radiation * pre-existing mal absorption syndrome, irritable bowel syndrome or other clinical situation which could affect oral absorption. * evidence of concurrent (\< 5 years) second malignancy * mental disorders. * inability to give written informed consent.

Keywords: carcinoma, non-small-cell lung docetaxel