Kornimate/medical-research-clean huggingface dataset:
pain related variables

Conditions: Chronic Neck Pain; Musculoskeletal Pain; Pain Modulation; Cortical Plasticity; Conditioned Pain Modulation; Temporal Summation

Summary: chronic neck pain is a common problem among the general population. patients with chronic neck pain used health care services twice as much as the population on average, mainly due to intense pain intensity. it is well-known that pain intensity depends on the association of pain processing in several levels of central pain processing. identifying the association between conditioned pain modulation, temporal summation, and somatosensory representation, all represent separate central pain processing, will provide an opportunity to develop treatment strategies.


Eligibility criteria:
inclusion criteria: * pain in the back of the neck region * pain longer than 3 months * pain intensity at least 3 based on the visual analog scale exclusion criteria: * vertebra fracture * fibromyalgia * chronic fatigue syndrome * surgery to the neck or shoulder * radicular pain * neurologic deficit due to disk hernia * spinal stenosis
a multiple dose study of mk-3614 (mk-3614-002)

Conditions: Hypertension

Summary: this study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple doses of mk-3614 in male participants with mild to moderate hypertension. the primary hypotheses are: 1) multiple oral doses of mk-3614 are sufficiently safe and well tolerated to permit continued clinical investigation 2) aortic augmentation index (aix) is reduced 24 hours post the last dose of mk-3614 administered compared to placebo and 3) increase in the 12-hour weighted averages (twa 0-12hours) of the heart rate is within 15 beats per minute (bpm) of baseline on first day of multiple dosing of mk-3614 and within 10 bpm of baseline on last day of multiple dosing of mk-3614.


Eligibility criteria:
inclusion criteria: * has mild to moderate hypertension * has grade 1 or 2 arterial hypertension being treated with a single antihypertensive drug * has been a nonsmoker and/or has not used nicotine or nicotine-containing products for at least approximately 6 months; or who have discontinued smoking or the use of nicotine/nicotine-containing products for at least approximately 3 months * is in generally good health exclusion criteria: * has a history of clinically significant abnormalities or diseases * has a history of stroke, chronic seizures, or major neurological disorder * has a functional disability that can interfere with rising from a sitting position to the standing position * has any personal or family history of a bleeding or a clotting disorder * has a history of frequent nose bleeds or has recurrent or active gingivitis * has a history of cancer * has a history of clinically significant cardiac disease * is unable to refrain from or anticipates the use of any medication, including prescription and non-prescription drugs or herbal remedies approximately 2 weeks prior to the administration of study drug * consumes excessive amounts of alcohol * consumes excessive amounts of caffeinated beverages per day * has had major surgery, donated or lost 1 unit of blood or participated in another investigational study within 4 weeks of study * has a history of significant multiple and/or severe allergies (including latex) to prescription or non-prescription drugs or food * is currently a regular user of any illicit drugs or has a history of drug abuse within approximately 1 year
effects of pomegranate juice on oxidative stress in patients with type2 diabetes

Conditions: Diabetes Type 2

Summary: introduction: diabetes mellitus a chronic diseases, is the most common and important metabolic disease in human. increased free radicals production due to hyperglycemia produces oxidative stress which worsens the disease and its complications. pomegranate juice has antioxidant and antiatherosclerotic properties. the present study was planned to evaluate the effects of pomegranate juice consumption on glycemic control, lipid profile,blood pressure and oxidative stress in patients with type 2 diabetes


Eligibility criteria:
inclusion criteria: * age of 40-65 years * body mass index 18.5-30 * fasting blood glucose ≥ 126 mg/dl exclusion criteria: * smoking * insulin for blood glucose control * taking estrogen or progesterone (if female) * taking antioxidant supplements * suffering from any other chronic diseases * participants are also excluded if they missed more than 10% of their pomegranate juice packs

Keywords: pomegranate diabetes oxidative stress
safety study of sublingual immunotherapy tablets of house dust mite allergen extracts

Conditions: Asthma; House Dust Mite Allergy

Summary: the purpose of this study is to investigate the safety of different doses of sublingual tablets of house dust mite allergen extracts in adults with house dust mite-associated allergic asthma.


Eligibility criteria:
inclusion criteria: * written informed consent. * male or female patient from 18 to 50 years. * diagnosed asthma with medical history consistent with hdm-induced allergic asthma. * positive spt to house dust mites(hdm)and hdm-specific ige serum value ≥ 0.7 ku/l. * stable asthma treatments. * spirometry with best fev1 \> 70% of the predicted value. * spirometry with reversibility of fev1 of ≥ 12% and ≥ 200 ml. * asthma control test™ (act) score ≥ 20. exclusion criteria: * current smoker or former smoker with \> 10 pack/year history. * co-sensitisation to any allergen possibly leading to clinically relevant respiratory allergy likely to significantly change the symptoms of the patient throughout the treatment period. * patient with a past or current disease, which as judged by the investigator, may affect the patient's participation in or the outcome of this study. * patient with any oral condition that could confound the safety assessments or planning to have a dental extraction during the study. * female patient pregnant or breast-feeding/lactating. * female patient of childbearing potential not using a medically accepted contraceptive method. * patient treated with beta-blockers, tricyclic antidepressants or monoamine oxidase inhibitors (maois). * patient who received allergen immunotherapy for hdm in the last 10 years. * ongoing treatment by immunotherapy with another allergen.
novel peptide vaccination for patients with advanced renal cell carcinoma

Conditions: Renal Cell Carcinoma

Summary: the purpose of this study is to evaluate the safety and ctl reaction of novel peptide vaccination for advanced renal cell carcinoma


Eligibility criteria:
inclusion criteria: disease characteristics advanced renal cell carcinoma which already showed resistance to standard treatments patients characteristics 1. patients who showed resistance to hormonal therapy and chemotherapy 2. histological diagnosis is adenocarcinoma 3. hla-a\*0201/0206 4. ecog performance status of 0 to 2 5. age ≥ 20 years, ≤80 years 6. wbc≥ 2,000/mm³, ≤12000/mm³ hemoglobin≥ 8.0g/dl platelet count ≥ 70000/mm³ ast, alt ≤100 iu/l total bilirubin ≤ 1.5 mg/dl creatinine ≤ 1.0 mg/dl pao2≥ 70mmhg 7. life expectancy ≥ 3months 8. able and willing to give valid written informed consent exclusion criteria: 1. pregnancy (women of childbearing potential: refusal or inability to use effective means of contraception) 2. breastfeeding 3. patients willing to childbearing ( refusal or inability to use effective means of contraception) 4. serious infections requiring antibiotics 5. concomitant treatment with steroids or immunosuppressing agent 6. other malignancy difficult to control. 7. decision of unsuitableness by principal investigator or physician-in-charge
electrical impedance tomography guided assessment of optimum peep levels during mechanical ventilation in lateral decubitus position

Conditions: Mechanical Ventilation; Bioelectrical Impedance

Summary: goal of this study is to determine optimal peep levels for patients undergoing surgery in lateral decubitus position. patients will be randomized into 3 groups - peep 0, 5 and 10 mbar. endotracheal anesthesia will be conducted with propofol, fentanyl, rocuronium and sevoflurane/o2/air gas mixture. patients with preexisting lung disease, organ transplants and disseminated malignant disease will be excluded. demographic data - age, weight, height, asa status, smoking history will be recorded. eit measured parameters - tidal variation ratio of nondependent and dependent lung, regional end-tidal and end-expiratory lung impedances as well as horizontal and vertical centers of ventilation will be recorded and calculated at 3 time points - before anesthesia induction, 5 minutes after lateral positioning of the patient and 90 minutes after lateral positioning. abgs will be sampled to calculate aa gradient and horovitz quotient at those time points as well as measured hemodynamic parameters (hr, bp, ci, svi). primary endpoints for the study are nondependent/dependent tidal variation ratios measured at predefined time points and changes in abgs. secondary endpoints are number of postoperative pulmonary complications (defined as new onset of pneumonia during 28 days of followup), length of hospital stay and changes in hemodynamic parameters.


Eligibility criteria:
inclusion criteria: * patients scheduled for nephrectomy, adrenalectomy or urterotomy surgery which will be performed in lateral decubitus position * signed informed consent form exclusion criteria: * preexisting moderate to severe obstructive (gold score \> 1) or restrictive lung disease (fvc \< 85%) * history of organ transplant * disseminated malignant disease * pregnancy

Keywords: peep electrical impedance tomography mechanical ventialtion
tailoring a mindful intervention to enhance opioid treatment

Conditions: Opioid-use Disorder

Summary: the main aim of this study is to better understand whether yoga can be blended with mindfulness as an additional intervention for people receiving medication assisted treatment at a hartford-based community agency. if this program is acceptable to participants, then additional studies can allow us to determine its impact on stress and cravings. this intervention, developed by the researchers, is called being.

this study is a micro-trial of our mindful yoga intervention, being, tailored to the mat clients. this study adapts an existing manualized program of yoga and mindfulness intervention (being) for mat participants. particularly important is addressing potential challenges and concerns regarding acceptability and feasibility of implementation in vulnerable males with substance dependence. we are enlisting the support of a mindful yoga expert with experience in related populations (i.e., previously incarcerated male veterans with mental health issues) in the adaptation process. this study is designed primarily to test the feasibility of the implementation of the intervention. we cannot draw statistically valid conclusions about the impact the intervention on outcomes, given the overall study design. we plan to collect participant feedback on whether or not the intervention is acceptable. we also want to evaluate the availability, accessibility, acceptability and feasibility of collecting certain measures that would be collected in a subsequent adequately powered treatment study.

Eligibility criteria:
inclusion criteria: * receiving medication assisted treatment 18 years or older released from incarceration within the past year currently receiving services from the partnering community agency english speaking exclusion criteria: * under 18 years old non-english speaking current incarcerated not receiving medication assisted treatment not receiving services from the partnering community agency

Keywords: medication assisted treatment
energy expenditure, sleep and macronutrients

Conditions: Obesity; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms

Summary: the purpose of this study is to determine energy expenditure and sleep in response to protein/carbohydrate and fat ratio of the diet over a short-term and long-term period of time.

the prevalence of obesity has increased worldwide to epidemic proportions. for long-term treatment success permanent lifestyle changes are necessary with regard to approach to food, physical activity patterns and behavior to emotional stress. moreover, an association has been shown between sleep disturbance and obesity. weight loss strategies regarding food intake regulation mainly focused on changing patterns of fat and carbohydrate consumption during the last decades. the role of protein has largely been ignored. however, protein has been observed to increase satiety and energy expenditure to a greater extent than carbohydrate and fat and can therefore reduce energy intake. however, it still has to be confirmed if this effect is permanent or transient over a longer period of time. moreover, dietary intakes may significantly affect sleep when macronutrient intakes are manipulated. since sleep deprivation has been recognized as a risk factor for obesity, improving sleep by a change in macronutrient intake would be promising in the treatment of obesity.

Eligibility criteria:
inclusion criteria: * healthy * age between 18-35 years * bmi 18-27 kg/m2 * non-smoking * weight stable (weight change \< 3 kg during the last 6 months) * no sleeping problems * not using a more than moderate amount of alcohol (\> 10 consumptions/wk) * not using medication or supplements except for oral contraceptives in women exclusion criteria: * not healthy * do not meet the criteria for bmi and age * smoking * not being weight stable * using medication or supplements except for oral contraceptives in women * sleeping problems * using a more than moderate alcohol consumption * pregnant or lactating * allergic for the used food items

Keywords: energy expenditure sleep protein carbohydrate
postoperatory recovery in advanced ovarian cancer, fast-track protocol vs. classical management

Conditions: Median Length of Stay; Readmission Rate; Surgery Related Complications Rate; Cost Per Patient Rate

Summary: the concept of fast-trak or enhanced recovery after surgery ( eras) represents a new approach to the management of patients undergoing major surgery that re-examine traditional practices, replacing them if necessary with the best evidence based practices, creating a multimodal perioperative care pathway designed to achieve early recovery. in colorectal cancer surgery , as well as in a number of other procedures it has been shown to reduce hospitalization by more than 30% without increasing the rate complications or readmissions. however information on the results of fast-track protocols when applied to gynecological patients is sparse, being especially notorious the lack of data regarding the efficacy of fast-track in the management of advanced gynecological cancer. hypothesis: the application of a fast-track protocol in the management of patients with advanced ovarian cancer( stage iii, iv and relapses) may improve the postoperatory recovery of these patients allowing for an early discharge and significant cost reduction, when compared with de usual management, without increasing the number readmission or surgery related complications.


Eligibility criteria:
inclusion criteria: * 18 years or more * advanced ovarian cancer ( figo stages iii-iv, and relapses) tributary to laparotomic surgical management. * patient accepts participation in the study and signs informed consent. exclusion criteria: * asa iv * active ischemic cardiac condition * advanced cirrhosis ( child-pugh b -c). * severe psychiatric condition ( patient not capable of giving her informed consent properly, not capable or not willing to attend follow-up visits).

Keywords: enhanced recovery after surgery eras fast-track ovarian cancer gynecologic surgery gynecology oncology median length of stay readmission rate surgery related complications cost
impact of virtual reality (e-nature vr) during hospitalization in adult intensive care unit

Conditions: Pain

Summary: randomized clinical trial to analyze the perceived impact of the virtual reality intervention on the experience of pain and well-being, and the influence on vital signs and the relationship with the length of stay in the intensive care unit.

the highly specialized and complex technology used in intensive care units to provide continuous monitoring of the patient health context makes possible to increase the survival of patients with critical and unstable clinical status, but increases the triggering factors of the stress of hospitalized patients. staying in these therapy units is accompanied by additional stress, confusional mental states, cognitive dysfunction, and depression. virtual reality is a technique that involves the use of computer technology to create the effect of an interactive three-dimensional world in which objects have a spatial presence reducing the suffering related to a medical procedure, without side effects and without the need for additional personnel. actual exposure to nature can be difficult to achieve for patients admitted to intensive care. therefore, exposure to nature via media devices, and virtual reality (vr) is considered a promising technology due to its advantage in creating a sense of immersion. furthermore, some evidence indicates that virtual nature can improve attentional resources, cognitive performance, and pain experience. this clinical trial aims to analyze the influence of vr use in patients of intensive care unit (icu). after informed the consent form, participants will be randomly into control and intervention groups. blood pressure, heart rate, respiratory rate, oxygen saturation will be evaluated, in addition to the experience of well-being and pain immediately before and immediately after the intervention for 2 consecutive days.the hypothesis of the study is that vr will positively influence vital signs and lived experiences, which will consequently reduce the length of stay in the icu.

Eligibility criteria:
inclusion criteria: * individuals of both sexes; * without communication, vision, hearing or intellectual disabilities; * capable of mental to fill in the questionnaires; * who watch at least 5 minutes of the video, minimum physiological immersion time. exclusion criteria: * use of sedatives; * those who experience considerable discomfort possibly caused by virtual reality such as nausea, dizziness or headache, with a history of vertigo, nausea, vomiting; * convulsion, labyrinthitis, epilepsy, dementia, mental confusion, psychomotor agitation; * claustrophobia or expressing a desire to discontinue the study; * patients who use anticholinergic drugs (antipsychotics and benzodiazepines); * delirium; * clinical worsening.

Keywords: virtual reality intensive care unit nature wellness
urinary catheter self-care management

Conditions: Chronic Diseases

Summary: it is important for healthcare professionals to be sensitive to the needs of patients undergoing urinary catheterization. patients and their relatives should be educated, guided and supported by nurses and other healthcare professionals. the aim of this study was to determine the effect of education given to patients with urinary catheterization on urinary catheter self-care management and urinary tract infection status. is planned as an experimental research.

the most important risk factor in the development of healthcare-associated infections of the urinary system is the insertion of a urinary catheter. because when a urinary catheter is inserted, the possibility of developing daily bacteriuria inthe patient increases. urinary catheter application can cause the development of fungal infections as well as bacterial infections in the patient. although most of these infections are asymptomatic and do not pose a threat, symptomatic serious infections rarely occur. may occur. there is a risk of catheter-associated urinary tract infection in both long and short-term catheterization. this risk increases as the duration of catheterization increases. according to the nursing regulation published in 2011 in our country, the initiatives in this direction are expected to be continued by nurses. therefore, in this study, the knowledge and practices of patients with urinary catheter will be examined and the effect of the education given on urinary catheter self-care management and urinary tract infection status will be evaluated. it is thought that the results of the study will guide patients with urinary catheters and nurses who provide care about the care and education of patients.

Eligibility criteria:
inclusion criteria: * volunteer to participate in the study * urinary catheterization * being conscious * to be able to do self-care exclusion criteria: * not volunteering to participate in the study * lack of awareness * inability to take care of themselves
normal oxygenation versus hyperoxia in the intensive care unit (icu)

Conditions: Nervous System Diseases; Respiratory Tract Diseases; Cardiovascular Diseases; Immune System Diseases

Summary: oxygen administration is a common practice in intensive care units, although concern is growing about oxygen toxicity. the aim of the study is to access whether a rigorous maintenance of a state of normal oxygenation in critically ill patients could obtain better outcomes, such as mortality, infections and organ failures, in comparison to conventional oxygen therapy practice.


Eligibility criteria:
inclusion criteria: * all patients admitted in a post-operative and medical intensive care unit with expected admission of at least three days. informed consensus as soon as possible exclusion criteria: * minority * patient discharged from icu and successively re-admitted * patient enrolled in other studies * expected survival shorter than 24 hours

Keywords: oxygen hyperoxia intensive care unit mortality organ dysfunction postoperative care
oral verses patch trial in menopausal women - individualisation of oestrogen therapy

Conditions: Venous Thrombosis; Insulin Resistance

Summary: ultra-low-dose oral e2/d will have more beneficial effects than trans-dermal hrt on lipids and insulin resistance in postmenopausal women, whilst adverse effects on coagulation will be avoided.

following screening for eligibility, women will be studied at baseline and then randomized to one of two groups: group a administered femoston conti - oral oestradiol 17β 0.5 mg/dydrogesterone 2.5 mg daily for the duration of the treatment phase (24 weeks) group b administered ½ evorel conti patches - trans-dermal estradiol 25 mcg/norethisterone acetate 85 mcg (½ evorel conti patches) daily for the duration of the treatment phase (24 weeks). studies will be repeated after 6 months of therapy at the follow up visit.

Eligibility criteria:
inclusion criteria: * healthy and postmenopausal woman who have had a normal ultrasound result * aged 40 - 60 years * at least 1 year post last menstrual period (per participant report) * bmi 18 - 32 * normal mammogram within 2 years of study commencement * continue on any concomitant medications without any change during the study give informed consent exclusion criteria: * estrogen or androgen therapy during preceding 3 months * use of hormone implants during the preceding 12 months * have received any medications which may interfere with the study (ssri, antiandrogens, * pde5 inhibitors, dhea, serms) * have a significant psychiatric disorder * have a history of breast or oestrogen dependent cancer * have diabetes, thrombo-embolic disorders (recent mi angina dvt varicose veins or recurrent dvt), cardiovascular disease, liver disease any condition affecting carbohydrate metabolism, uncontrolled hypertension and uncontrolled hyperlipidaemia * untreated endometrial hyperplasia * dubin-johnson syndrome and rotor syndrome * undiagnosed vaginal bleeding * women who have had a hysterectomy