Kornimate/medical-research-clean huggingface dataset:
post operative pain control: morphine vs fentanyl

Conditions: Post Operative Analgesia

Summary: aim of this study is to compare benefits and disadvantages in using continuous infusion of morphine or fentanyl for post operative analgesia.


Eligibility criteria:
inclusion criteria: * asa 1 or 2 patients * undergoing major gynaecological surgery exclusion criteria: * age \> 60 years * obesity (bmi\>30 kg/m2) * cardiac and respiratory diseases * renal impairment * liver disorders * allergies to any drug used in the study

Keywords: post operative analgesia, morphine, fentanyl
cbt for premature ventricular contractions

Conditions: Ventricular Premature Complexes

Summary: the purpose of the present interdisciplinary research program is to develop and evaluate a disease-specific cognitive behavior therapy (cbt) protocol to increase quality of life (qol) and reduce symptom burden in patients with premature ventricular contractions (pvc).

patients will be recruited in collaboration with arrythmia specialist units in stockholm and through advertisement in local newspapers and social media. all patients giving informed consent will be screened thoroughly by the research nurse and a psychologist before included by the study cardiologist. 20-30 patients that meet eligibility criteria will be included and receive 8-10 sessions of cognitive behavior therapy during 8-10 weeks. due to the current covid-19 pandemic, treatment will be delivered face-to face through a secure digital platform. the psychologist delivering the treatment will have direct access to the study cardiologist during treatment. follow-up at 3 and 6 months.

Eligibility criteria:
inclusion * 18-70 years old * pvcs that cause moderate to severe symptoms and leads to significant distress or interferes with daily life. * optimal medical treatment in the opinion of the treating physician. * able to read and write in swedish. exclusion * structural heart disease including previous myocardial infarction, heart failure with preserved or reduced left ventricular ejection fraction, valvular disease, previous cardiac surgery. * other arrhythmia or severe medical illness; * scheduled for ablation therapy or any other cardiovascular intervention * any medical restriction to physical exercise. * severe depression or risk of suicide; * alcohol dependency. all patients will undergo thorough cardiological and psychological assessment to ensure that eligibility criteria are met.
retrospective epidemiological study of lung cancer with low-dose multislice computed tomography

Conditions: Lung Cancer

Summary: lung cancer is one of the leading causes of cancer-related death in taiwan. early diagnosis of lung cancer may improve cancer survival. low-dose computed tomography (ldct) was thought to be the best screening tool for lung cancer. however, there is growing concerns about radiation exposure, high cost, and high rate of false-positive screening result. epidemiology data for ldct screening in taiwan is lacking. national taiwan university hospital chu-tung branch (ntuhct) initiated the lung cancer screening by ldct since june 2015. many people can get the ldct screening with affordable price with the subsidy from enterprise donation. the purpose of this study is establishing local epidemiological result via telephone follow-up and patients' medical records retrospectively.

lung cancer is one of the leading causes of cancer-related death in taiwan. early diagnosis of lung cancer may improve cancer survival. low-dose computed tomography (ldct) was thought to be the best screening tool for lung cancer. however, there is growing concerns about radiation exposure, high cost, and high rate of false-positive screening result. epidemiology data for ldct screening in taiwan is lacking. national taiwan university hospital chu-tung branch (ntuhct) initiated the lung cancer screening by ldct since june 2015. many people can get the ldct screening with affordable price with the subsidy from enterprise donation. the purpose of this study is establishing local epidemiological result via telephone follow-up and patients' medical records retrospectively. aim: to establish the local epidemiological data for lung pathology, emphysema, bronchiectasis and other lung disease. methods: since june 2015, more than 6000 ldct were done at the ntuhct. roughly 6 months after the test telephone follow-ups about patient satisfactions, self-awareness of ct results, medical consultations and other related behaviors, and willingness of coming back for another test were routinely done. retrospective secondary data analysis will be performed on the telephone follow-up results to establish local epidemiology data on lung pathology as well as information on screening accuracy of ldct. customers are also queried about willingness to provide their medical records, and linkage to national health insurance database with informed consents to provide more advanced information on their long-term outcomes. keywords: lung cancer, low dose computed tomography, screening.

Eligibility criteria:
inclusion criteria: * self pay the ldct in national taiwan university hospital chu-tung branch exclusion criteria: -

Keywords: ldct, screening
make up for the epinephrine autoinjector

Conditions: Anaphylaxis

Summary: part of the problems related with proper use of epinephrine autoinjector may be related with the design of the autoinjector itself.the aim of the study is to investigate whether minor modifications in the design of currently available epinephrine autoinjector ease its use and abrogate common use errors.

all interns except the ones who previously worked in allergy department in a medical school were invited to the study. two identical epinephrine autoinjector trainers (epipen trainer®) were used, one of which was modified by changing gray safety cap to red and placing a yellow arrow pointing to the black injection tip. written and visual instruction sheet for each trainer was provided. participants were asked to demonstrate the use of epipen trainer either with the original or the modified one. they were scored and timed for demonstration. primary study parameter was the rate of participants correctly demonstrating the use of epinephrine autoinjector. secondary study parameters were the mean total score, mean time required to administer autoinjector and unintentional self injection of autoinjector into thumb.

Eligibility criteria:
inclusion criteria:we invited all interns in our faculty to inform about the study and included the ones who gave informed consent - exclusion criteria:interns who previously worked in allergy department were excluded. -

Keywords: anaphylaxis, autoinjector, design, epinephrine
a study into the effect of seprafilm in open total thyroidectomy

Conditions: Thyroid Carcinoma

Summary: the investigators intend to determine the role of seprafilm, a popular anti-adhesive agent in minimising internal adhesion formation in the neck after thyroid surgery and therefore reduce swallowing discomfort experienced by patients after surgery.

thyroid surgery not only constitutes one of the main pillars in the treatment of thyroid cancers, but is also employed in the management of symptomatic goitres. occasionally, it is mandated in patients with thyrotoxicosis refractory to medical therapy. while thyroid surgery can be performed with low risks such that patients rarely have to stay beyond three days in hospital, the track record of thyroid surgery is somewhat blemished by the unfortunate side effects associated with the neck scarring after thyroid surgery. not uncommonly, patients experience discomfort in the neck region after thyroid surgery; in the extreme of cases, patients may even complain of a lifelong pulling sensation in the neck area during eating. the anti-adhesive properties of seprafilm are well established in animal studies and affirmed by clinical observations in abdominal surgeries that utilize this material. thus, seprafilm is routinely used in instances when a surgeon foresees a need to perform abdominal surgery on the same patient in future, or during the fashioning of a temporary stoma. the safety profile of seprafilm in thyroidectomy has also been shown by a recent study conducted by a group of clinicians in seoul. we postulate that the application of seprafilm to the surgical wound towards the end of a thyroidectomy significantly reduces internal adhesion formation in the neck region. by achieving this objective, we hope to improve patients' satisfaction with thyroid surgery in terms of ease of swallowing after surgery.

Eligibility criteria:
inclusion criteria: * age 21-75 * histological confirmation of differentiated thyroid cancer requiring surgery, symptomatic goiters, thyroid nodules requiring histological analysis, or thyrotoxicosis poorly controlled by medication. * undergoing total thyroidectomy exclusion criteria: * previous neck surgery * previous neck radiotherapy * patients with a known history of keloids * patients with a known history of motility disorders in the upper gastrointestinal tract and preexisting swallowing difficulty. * patients with metastatic disease; patients with disease that would require postop radiation therapy, radionuclide iodine therapy and any adjuvant therapies. * patients with advanced disease that would require radical or modified neck dissection * patients with lobe larger than 10 cm, or nodule larger than 8 cm which require extensive dissection that may confound the study * patients with connective tissue diseases and chronic diseases on long-term medications that may interfere with wound healings such as steroids

Keywords: total thyroidectomy seprafilm swallowing difficulty post thyroidectomy
the life experience of young women (age 18-38) who live with congenital heart disease

Conditions: Women With Congenital Heart Diseases

Summary: this research will focus on young women between the ages of 18-38 who underwent a heart operation and their life experiences. this research will focus on these life events and the paradigm of these women being raised as "heart sick," and consequently lacking self-esteem (frigiola, bull, \& wray, 2014; hickey et al., 2012). most qualitative studies focusing on the quality of life compare men and women, completely ignoring women's body image and the experience of womanhood (hickey et al., 2012; hövels-gürich et al., 2007; sarikouch, et al., 2013). this study aims to focus on women's stories about their life experiences and the influence of surgery(ies) on their daily life using an the qualitative phenomenological approach.


Eligibility criteria:
inclusion criteria: * atrial septal defect or asd, * ventricle septal defect or vsd, * tetralogy of fallot or tof * translocation of great arteries or tga * underwent heart operation * hebrew speakers that are able to understand the meanings of the questions and tell their life stories. exclusion criteria: * non hebrew speakers * did not underwent heart surgery.
anrotinib in combination with capecitabine in advanced triple negative breast cancer

Conditions: Metastatic Triple-Negative Breast Cancer

Summary: the hypothesis of this study is to discover if the capecitabine plus anlotinib can shrink or slow the growth of pretreated advanced tnbc. it is a single-arm phase ii clinical study of capecitabine combined with antinib in the treatment of recurrent or metastatic triple-negative breast cancer

it is a single-arm phase ii clinical study of capecitabine combined with antinib in the treatment of recurrent or metastatic triple-negative breast cancer. the hypothesis of this study is to discover if the capecitabine plus anlotinib can shrink or slow the growth of pretreated advanced tnbc.

Eligibility criteria:
inclusion criteria: 1. female aged between 18 and 70; 2. recurrence or metastasis of tnbc confirmed by histological or cytological methods, tnbc definitions of er, pr and her-2 are negative, if there is metastasis pathology, the histological pathology of metastasis shall prevail.er and pr negative were defined as er \< 10% positive and pr \< 10% positive. 3. disease progression after at least one prior systemic treatment and anthracycline and/or taxane use;note: for neoadjuvant/adjuvant therapy, recurrence or disease progression during treatment or within 6 months of discontinuation of treatment should be counted as first-line systemic treatment failure; 4. there should be at least one measurable lesion according to the efficacy evaluation criteria for solid tumors (recist version 1.1) exclusion criteria: 1. the number of previous treatment lines (including postoperative adjuvant therapy) \>4 lines 2. symptomatic central system metastases.patients with stable asymptomatic bms who have received brain radiation and who have at least one other evaluable target in addition to the bms can be enrolled (evaluable target should be at least 4 weeks away from the last radiotherapy). 3. new bisphosphonate or dinoselmer treatment for bone metastases was initiated within 28 days prior to study initiation.(subjects are permitted if they have already been treated with bisphosphonate or dinoselmer for at least 4 weeks of optimal stable administration prior to study initiation.)subjects already enrolled in this study may begin treatment with bisphosphonate or dinoselmer for bone metastases after the first post-treatment evaluation
handheld computers to improve adherence to anti-hiv drug regimens

Conditions: HIV Infections

Summary: while anti-hiv drugs can significantly reduce viral loads, the medication regimens can be complex, and patients must take them correctly for the best effect. nonadherent patients risk developing drug resistant hiv strains. the purpose of this study is to evaluate the effectiveness of a handheld computerized system designed to help patients take their drugs correctly.

as the use of protease inhibitors and other antiretroviral medications has increased, multiple drug resistant hiv strains have emerged, demonstrating the need for improved patient adherence to complex drug regimens. individual computerized adherence systems have been proposed as a mechanism for improving patient adherence. this study will utilize advanced computer and communication technologies to produce a handheld (pda) product for hiv/aids patients. the system serves as a patient reminder system, addresses problems of missed medications, and monitors severity of side effects. this study will evaluate the efficacy of the system as an adherence intervention. participants in the study will be randomized to either the intervention or a control group. participants will use the pda daily for medication reminders, alarms, adherence tracking, and as a source of information on hiv/aids. the study will last 15 weeks. each participant will have 6 study interviews and 2 quality control interviews. study interviews will include adherence questionnaires, blood tests for viral load and cd4 data, and quality of life assessments.

Eligibility criteria:
inclusion criteria * hiv positive * currently taking medications for hiv/aids.

Keywords: adherence treatment experienced
value of 6-minute walk test in grown ups with congenital heart defects (guch)

Conditions: Congenital Heart Disease

Summary: the six-minute walk test is an established submaximal exercise test. its role in examination of grown-up patients with congenital heart disease (guch) is not studied so far. objective of this study was a comparison of the 6mwt with other established parameters of functional capacity, in grown-up patients with guch.


Eligibility criteria:
inclusion criteria: * congenital heart defect * \> 18 years exclusion criteria: * mental or physical incapability of exercise testing * non-cardiac limitations of physical capacity, as e.g. orthopedic diseases or febrile infections * severe psychiatric diseases

Keywords: congenital heart disease six minute walk test exercise testing peak oxygen uptake
effect of kinesiotape versus myofascial release on postnatal low back pain

Conditions: Low Back Pain

Summary: this study aims to determine the difference between the effect of kinesiotape and myofascial release in the treatment of postnatal low back pain.

postpartum back pain may occur in up to 44% of women after childbirth. people who have chronic back pain may have a limited range of motion and/or tenderness upon touch. therapeutic kt can benefit a wide variety of musculoskeletal and sports injuries, plus inflammatory conditions. according to the kinesiotape method manual, this traction promotes an elevation of the epidermis and reduces pressure on the mechanoreceptors located below the dermis, thereby reducing nociceptive stimuli and low back pain. myofascial release (mfr) is a treatment that uses gentle pressure and stretching to facilitate the release of fascial restrictions caused by accidents, injury, stress, repetitive use, and traumatic or surgical scarring. myofascial release is a form of soft tissue therapy used to treat somatic dysfunction and accompanying pain and restriction of motion. this is accomplished by relaxing the contracted muscle, increasing circulation, increasing venous and lymphatic drainage, and stimulating the stretch reflex of muscles and overlying fascia so, reducing low back pain.

Eligibility criteria:
inclusion criteria: * their ages will be ranged from 20 to 35 years old. * their body mass index (bmi) will not exceed 30 kg/m2. * women will be postnatal period by 6-8 weeks. * all women will be diagnosed by the physician as postnatal low back pain. exclusion criteria: * spinal fracture or any other neurological disorders. * lumbar disc herniation or degenerative disc disease * lumbar spinal stenosis from lumbar disc herniation, degenerative joint disease, or spondylolisthesis * women with bmi exceed 30 kg/m2. * patients who have polyneuropathy or other neurological disorders. * skin disease interferes with kinesiotape or myofascial release application.
omega-3 and vitamin d supplements in childhood t1d

Conditions: Type 1 Diabetes Mellitus

Summary: the study was conducted in 64 patients with t1d of which 26 had the onset in 2017, and 38 in 2016, 2015 and 2014. all received vitamin d 1000 iu /day since disease's onset. moreover in the 2017 group omega-3 were supplemented, starting within 3 and 6 months from the disease's outbreak, and those were considered cases; the other 38 were enrolled as controls. four cases and one control dropped out. finally in 59/64 were compared data of glycosylated hemoglobin percentage (hba1c%), average insulin daily requirement (iu/kg/day), and idaa1c \[insulin daily dose adjusted for hba1c, a surrogate index of residual endogen insulin secretion, calculated as insulin daily dose (iu/kg/24 h) x 4 + hba1c%\] at recruitment (t0), and 3 (t3), 6 (t6), 12 (t12) months after. t0 in cases was at the start of supplementation of omega-3, and consequently 3, 6 and 12 months after; in controls were found data in clinical records of outpatient beginning from the 3rd month and 3-6-12 months thereafter. then 22 cases and 37 controls were compared.

was assessed the comparability of cases and controls at baseline for gender, age, body weight, hba1c% and device for insulin therapy. the preparation of omega-3 administered was a highly purified fish oil to avoid pollutants, containing a mixture of omega-3 long chain fatty acids standardized for contents of eicosapentaenoic acid (epa) and docosahexaenoic acid (dha) in a 2: 1 ratio, in capsules or in liquid form. the liquid preparation was used in the case of difficulties in swallowing capsules or concomitant celiac disease because it was certified as gluten-free (ener zone omega 3 rx® equipe enervit). the preparations contained antioxidants to preserve omega-3 lcfa, tocopherol (1 mg in 1 g of omega-3 lcfa), palmitate, and rosemary extract. epa and dha were administered at 50-60 mg/kg/day for 12 months. the investigation of arachidonic acid (aa)/epa ratios was performed in cases on recruitment (t0), and repeated after 3 (t3), 6 (t6), and 12 months (t12). cholecalciferol supplementation was fixed at 1000 iu/day (25 mcg/day), both in cases and controls. vitamin d level was determined as 25(oh)d level at the clinical onset of t1d, at t0, t3, t6, and t12 in cases, and at clinical onset of controls.

Eligibility criteria:
inclusion criteria: * all t1d patients aged 1-18 years whose disease onset had been in 2017, 2016, 2015, 2014 affering to the pediatric diabetology of aou novara (italy) * written consents of parents * without assumption of omega 3 supplementation before 2017 exclusion criteria: * renal cysts * sarcoidosis * histoplasmosis * hyperparathyroidis * lymphoma * tuberculosis * patients treated with drugs that could affect immunity or glucose metabolism, including corticosteroids, ciclosporin and tacrolimus

Keywords: omega3 t1d remission period honeymoon period aa/epa ratio
extraarticular distal radius fractures, x-fix or volar fixation

Conditions: Dorsally Displaced Intraarticular Distal Radius Fractures; Age 50 - 74 for Females or 60-74 for Males; Low Energy Trauma

Summary: distal radius fractures are treated surgically if severely displaced. this study aims to investigate the outcome after surgery. the investigators will randomize patients to either external fixation with optional addition of k-wires or open reduction and fixation with a volar plate.

this study has been merged with study nct01035359 and a new ethical permission has been granted by the swedish national ethic board

Eligibility criteria:
inclusion criteria: * female 50-74 years or male 60-74 years * dorsally displaced extraarticular distal radius fracture * dorsal angulation \>20 degrees measured from the plane perpendicular to the radius axis * low energy trauma * injury \<72 hours when diagnosed * patient independent of help for adl exclusion criteria: * earlier dysfunction in any wrist * other major injuries * rheumatoid arthritis or other systemic joint disease * dementia or severe psychiatric disease * severe medical condition making general anesthesia a considerable risk

Keywords: radius fracture wrist external fixation volar plate dash prwe
a study of efimosfermin alfa in participants with biopsy-confirmed cirrhosis (compensated) mash

Conditions: Metabolic Dysfunction-Associated Steatohepatitis

Summary: the purpose of this study is to evaluate the safety, tolerability, preliminary efficacy, and pharmacokinetics (pk) of efimosfermin in participants with metabolic dysfunction associated steatohepatitis (mash) and compensated cirrhosis consistent with stage f4 fibrosis.


Eligibility criteria:
inclusion criteria: * ability to understand and sign a written informed consent form (icf) * age 18 through 75 years at enrollment * history or presence of 2 or more of the 5 components of metabolic syndrome * liver biopsy confirmation of mash consistent with stage f4 fibrosis * other inclusion criteria may apply. exclusion criteria: * individuals with chronic liver disease from other causes, or any history or evidence of decompensated liver disease * history of type 1 diabetes * alanine aminotransferase (alt) or aspartate aminotransferase (ast) ≥5 × the upper limit of normal (uln) * other exclusion criteria may apply.

Keywords: fibroblast growth factor stage 4 fibrosis compensated cirrhosis