Kornimate/medical-research-clean huggingface dataset:
efficacy of ai ef screening by using smartphone application recorded plax view cardiac ultrasound video clips

Conditions: Heart Failure; Heart Failure With Reduced Ejection Fraction; Cardiac Failure; Echocardiography; Artificial Intelligence

Summary: assessing the efficacy of artificial intelligence in left ventricular function screening using parasternal long axis view cardiac ultrasound video clips abstract background: echocardiography serves as a fundamental diagnostic procedure for managing heart failure patients. data from thailand's ministry of public health reveals that there is a substantial patient population, with over 100,000 admissions annually due to this condition. nevertheless, the widespread implementation of echocardiography in this patient group remains challenging, primarily due to limitations in specialist resources, particularly in rural community hospitals. although modern community hospitals are equipped with ultrasound machines capable of basic cardiac assessment (e.g., parasternal long axis view), the demand for expert cardiologists remains a formidable obstacle to achieving comprehensive diagnostic capabilities. leveraging the capabilities of artificial intelligence (ai) technology, proficient in the accurate prediction and processing of diverse healthcare data types, offers a promising for addressing this prevailing issue. this study is designed to assess the effectiveness of ai in evaluating cardiac performance from parasternal long axis view ultrasound video clips obtained via the smartphone application. objectives: to evaluate the effectiveness of artificial intelligence in screening cardiac function from parasternal long axis view cardiac ultrasound video clips obtained through the smartphone application.

methods: the investigators built the smartphone application to collect parasternal long axis view video clips and used artificial intelligence "easy ef" to evaluate cardiac function. all samples that were evaluated for lvef by certified cardiologists, 70% of all clips were used to train ai, while the remaining 30% of clips were used to test if ai could process the results correctly. artificial intelligence aims to classify cardiac function into three groups: reduced ef, mildly reduced ef, and preserved lv.

Eligibility criteria:
inclusion criteria: * shot 5 second vdo clip of parasternal long axis heart ultrasound recorded by smartphone application "easy ef" without patient identification with result of ejection fraction that performed by certify cardiologist approved result exclusion criteria: * incomplete vdo clip (too much shaking, too shot recording) * lighting was inappropriate * inappropriate ultrasound framing * arrhythmia (atrial fibrillation)
safety study of llf580 in obese volunteers

Conditions: Obesity

Summary: the purpose of the study is to evaluate the safety and tolerability of multiple doses of llf580 administered subcutaneously over 3 months in obese subjects. in addition, the study will also determine early efficacy signals in various metabolic diseases associated with elevated triglycerides and/or obesity.


Eligibility criteria:
inclusion criteria: * body mass index (bmi) within the range of 30 to 45 kg/m2, inclusive, with ethnic adjustment (≥27.5 kg/m2 for asian individuals). * fasting triglyceride 150 - 500 mg/dl (1.69 - 5.65 mmol/l), inclusive, at screening. * able to communicate well with the investigator, to understand and comply with the requirements of the study. exclusion criteria: * history of hepatobilliary disease. * liver disease or liver injury as indicated by abnormal liver function tests. * chronic infection with human immunodeficiency virus (hiv), hepatitis b (hbv) or hepatitis c (hcv). * fasting triglycerides greater than or equal to 500 mg/dl \[5.65 mmol/l\], or concomitant use of drug treatment for hypertriglyceridemia (fibrates, omega-3 fatty acids, nicotinic acid). * history of pancreatic injury or pancreatitis. * history of hypersensitivity to drugs of similar biological class, fgf21 protein analogue, or fc fusion proteins. * history of bone disorders or low vitamin d level. * contraindications to mri. * change in body weight (more than 5% self-reported or 5 kg self-reported change during the previous 3 months). * use of weight loss drugs. * enrollment in a diet, weight loss or exercise programs.

Keywords: obesity hypertriglyceridemia
female genital schistosomiasis in tanzania

Conditions: Schistosomiasis Mansoni

Summary: a cross-sectional survey will be conducted among 200 volunteering women aged 18- 45 years and having had prior sexual activity living in the target villages of itilima and maswa districts, north-western tanzania. a single midday urine sample and two cervical-vaginal swabs (both self-collected and speculum-aided collected by a female healthcare worker) will be obtained from participating women and processed using urine filtration and polymerase chain reaction (pcr) for cervico-vaginal samples. a pre-tested structure questionnaire will be used to collect sociodemographic, clinical, and sampling acceptability information from participants.

a cross-sectional survey will be conducted among 200 volunteering women aged 18-45 years and having had prior sexual activity living in the target villages of itilima and maswa districts, north-western tanzania. a single midday urine sample and two cervical-vaginal swabs (both self-collected and speculum-aided collected by a female healthcare worker) will be obtained from participating women and processed using urine filtration and polymerase chain reaction (pcr) for cervico-vaginal samples. a pre-tested structure questionnaire will be used to collect sociodemographic, clinical, and sampling acceptability information from participants. prevalence of female genital schistosomiasis (fgs) will be estimated based on positivity of at least one genital specimen. quantitative data will be described using means/medians and standard deviation/interquartile range, as appropriate. qualitative data will be described as numbers and percentages, and compared using chi-squared or fisher exact test, as appropriate. sensitivity of the two genital sampling methods will be compared using the composite reference constituted by positivity in at least one genital swab, and the performance of the two methods compared using cohen's kappa statistics, fisher's exact test and parametric/nonparametric test for comparison of pcr ct values, as appropriate.

Eligibility criteria:
inclusion criteria: * women aged 18-45 years, * having had prior sexual activity (to allow speculum-aided gynaecological visit and genital sampling), * resident in any of the selected village of itilima and maswa districts, * irrespective of complaining of urogenital symptoms, * not reporting any exclusion criteria, * willing to participate to the study as documented by signing the informed consent form. exclusion criteria: * menstruation at the time of visit (since this limits visualization of the cervix and correct sampling); * no prior sexual activity (since this does not allow the use of a speculum in the visit); * known pregnancy; * documented treatment for schistosomiasis in the past 6 months; * age \ 45 years; * unwilling to sign the informed consent form.

Keywords: female genital schistosomiasis
mini-autogenous skin grafts with skin homografts versus autogenous skin graft for covering post burn wounds in children

Conditions: Burns

Summary: a prospective study comparing the use of mini-autogenous skin grafts and skin homograft versus autogenous skin grafts for covering post burn wounds in children.

a prospective study comparing the use of mini-autogenous skin grafts and skin homograft versus autogenous skin grafts for covering post burn wounds in children so that the patient can continue on his/her normal life early with less deformities

Eligibility criteria:
inclusion criteria: * this study will include children (3-12) years old with (10-30) % body surface area burns, admitted to assuit university hospital burn unit. * the raw areas in both upper and lower limbs will be the site of the study. exclusion criteria: * patients younger than 3 years old. * patients with burns more than 30% of total body surface area. * patients with medical or mental diseases.
extended-release sodium oxybate in children

Conditions: Narcolepsy Type 1 (NT 1)

Summary: the main objectives of this study are to determine the treatment preferences of children with narcolepsy type 1 between extended-release sodium oxybate and non-extended-release oxybates (sodium oxybate or a medication with the combination of calcium, magnesium, potassium, and sodium oxybates). the study will also assess the safety, convenience, and tolerability of extended-release sodium oxybate. additionally, the researchers aim to assess how well extended-release sodium oxybate works in treating narcolepsy type 1.


Eligibility criteria:
inclusion criteria: 1. participants must be under the care of a doctor at the stanford sleep clinic. 2. participants must have a documented diagnosis of narcolepsy type 1 shown by sleepiness and either: a spinal fluid marker for narcolepsy (hypocretin-1) at a specific level, or a history of sudden loss of muscle control (cataplexy), or a particular genetic marker for narcolepsy, or a sleep study showing a specific sleep pattern for narcolepsy. 3. parent(s), or guardian(s) have signed a consent form and the child must agree to participate. 4. participants are on a stable dose of medications exclusion criteria: participants who have any of the following conditions will not be included in the study 1. uncontrolled mental health problems 2. uncontrolled sleep problems that lead to sleepiness. 3. currently having thought about ending one's life or sadness or loss of interest 4. currently having a problem with illegal drug use 5. currently pregnant

Keywords: narcolepsy children sodium oxybate treatment
correlation between expression of hormonal receptors, clinical data, and methylation profile in meningiomas (methylrh-m)

Conditions: Meningioma

Summary: this research aims to explore the relationship between hormonal receptor expression and the clinical and histopathological characteristics of meningiomas. the underlying hypothesis is that hormonal receptor expression, as well as the methylation profile of their gene promoters, are associated with specific aspects of meningiomas and patients' clinical outcomes. the main objective is to study the correlation between the immunohistochemical expression of hormonal receptors and clinicopathological data. the secondary objectif is to study the correlation between the methylation profile of hormonal receptor gene promoters and their immunohistochemical expression.


Eligibility criteria:
inclusion criteria: * patients who underwent surgery for a meningioma at the university hospital of nancy between 2000 and 2022. exclusion criteria: * patients who did not express their consent to participate in the study. * patients with grade 2 or 3 meningiomas whose samples are no longer available or in insufficient quantity to perform an immunohistochemical study. * patients with grade 1 meningiomas not selected by randomization. * patients withdrawing their consent.

Keywords: meningioma hormonal receptors
physical therapy management in degenerative lumbar diseases and osteoporosis

Conditions: Low Back Pain

Summary: low back pain is a common health issue in elderly population. according to the statistics, more than 80% of taiwanese suffer low back pain in the life. the cause of low back pain includes lumbar spondylosis, osteoporosis, compression fracture, muscle strain, spondylolisthesis...etc. in addition to drugs and surgery, physical therapy is an alternative choice for conservative treatment. therefore, in this study, the investigators propose to analyze the physical examination, diagnostic methods, x ray, physical therapy records, physical therapy methods and clinical outcomes in patients with the diagnosis including lumbar spondylosis, low back pain, osteoporosis, compression fracture, back pain treated at national taiwan university hospital and received rehabilitation at the physical therapy center in recent ten years.


Eligibility criteria:
experimental group: inclusion criteria: * patients with the diagnosis including lumbar spondylosis, low back pain, osteoporosis, compression fracture, back pain treated at national taiwan university hospital * received rehabilitation at the physical therapy center in recent ten years. control group: inclusion criteria: * patients with the diagnosis including lumbar spondylosis, low back pain, osteoporosis, compression fracture, back pain treated at national taiwan university hospital * not received rehabilitation at the physical therapy center in recent ten years.

Keywords: physical therapy treated at ntuh and received rehabilitation at the ptc in recent ten years.
mortality in patients with severe covid-19 pneumonia who underwent tracheostomy

Conditions: Mechanical Ventilation; Covid19; Tracheostomy

Summary: background: invasive mechanical ventilation (imv) in covid-19 patients has been associated with a high mortality rate. in this context, the utility of tracheostomy has been questioned in this group of ill patients. this study aims to compare in-hospital mortality in covid-19 patients with and without tracheostomy due to prolonged imv methods: cohort study of adult covid-19 patients subjected to prolonged imv. since the first covid-19 case (march 3, 2020) up to november 30, 2020, all adult critical patients supported with imv by 10 days or more at the hospital clínico universidad de chile will be included in the cohort. pregnant women and non-adult patients will be excluded. baseline characteristics, comorbidities, laboratory data, disease severity, and ventilatory support will be retrospectively collected from clinical records. the indication of tracheostomy, as part of our standard of care, will be indicated by a team of specialists in intensive care medicine, following national guidelines, and consented to by the patient's family. the 90-days mortality rate will be the primary outcome, whereas imv days, hospital/cu length of stay, and the frequency of healthcare-associated infections will be the secondary outcomes. also, a follow-up interview will be performed one year after a hospital discharged in order to assess the vital status and quality of life. the mortality of patients subjected to tracheostomy will be compared with the group of patients without tracheostomy by logistic regression models. furthermore, propensity-score methods will be performed as a complementary analysis.


Eligibility criteria:
inclusion criteria: * covid-19 confirmed case * invasive mechanical ventilation by 10 days or longer exclusion criteria: * childhood * pregnant women
an open-label study of kw-3357

Conditions: Disseminated Intravascular Coagulation (DIC)

Summary: the purpose of this study is to evaluate the efficacy and safety of kw-3357 compared to plasma-derived antithrombin using multi-center, open-label, parallel-group, comparative method in patients with disseminated intravascular coagulation (dic) associated with infection.


Eligibility criteria:
inclusion criteria: * meet the accp/sccm-defined sepsis criteria * japanese association for acute medicine-defined dic criteria score \>= 4 * antithrombin activity \<= 70% * written informed consent from patient or guardian exclusion criteria: * anamnesis or complication of serious drug allergy * serious liver disorder, such as fulminant hepatitis and decompensated cirrhosis * pregnant, nursing, or possibly pregnant woman
influence of supervised stabilization exercises on postural control in patients after spine surgery.

Conditions: Low Back Pain

Summary: the aim of the study is to determine the impact of early rehabilitation in patients after lumbar spine surgery using microdiscectomy on balance, postural stability and foot pressure distribution. the tests will be carried out at the physical effort laboratory in gdańsk.

back pain (lbp) has become a major public health problem. in the case of pain in the lumbar spine, conservative or surgical treatment is used. in conservative treatment, patients undergo an appropriate rehabilitation program or use painkillers / anti-inflammatory drugs. when conservative treatment is unsuccessful, patients based on the mri image and neurosurgical consultation are referred to the lumbar spine microdiscectomy. therefore, patients consciously and voluntarily can start research on the effect of supervised exercises to stabilize the lumbar spine after single-level lumbar spine microdiscectomy on pain reduction, pressure distribution, balance, posture control, and basic functional tests. before the operation, during the first examinations, patients are informed about the ergonomic and behavioral procedure after the operation, and rehabilitation program. after surgery, a supervised exercise program begins three times a week for a month, lead by a qualified physiotherapist. supervision is carried out online using generally available applications, including whatsapp, messenger. after one month, patients are re-examined in the same way as before the surgery. the rehabilitation program after the microdiscectomy of the lumbar spine enables the voluntary extension of rehabilitation for another two months. during subsequent meetings with a physiotherapist, patients are taught new exercises that differ from week to week in terms of difficulty in performing, the number of repetitions, and the time to maintain tension. moreover, in the third month of the rehabilitation program, exercises with the use of a sensorimotor disc are planned. after completing the rehabilitation program, patients are invited for follow-up examinations six months and one year after the end of rehabilitation.

Eligibility criteria:
inclusion criteria: * age 20 to 65 years, neurosurgical assessment and mri imagine,discopathy, pernament low back pain with or without radiating to the lower limb. exclusion criteria: * patients beyond the age range, a previous lumbar spinal operation, spinal tumors, new fractures, intolerance of rehabilitation programs.

Keywords: low back pain, microdiscectomy, lumbar disc herniation, functional exercise, lumbar stabilization exercise
a study to evaluate pharmacodynamics, safety, tolerability and pharmacokinetics of mt-3995 in type ii diabetic nephropathy subjects with albuminuria

Conditions: Diabetic Nephropathy

Summary: the purpose of this study is to evaluate pharmacodynamics, safety, tolerability and pharmacokinetics of mt-3995 in type ii diabetic nephropathy subjects with albuminuria


Eligibility criteria:
inclusion criteria: * subjects with type ii diabetic nephropathy, who have been treated with angiotensin converting enzyme-inhibitor (ace-i) or angiotensin ii receptor blocker (arb) * glycosylated haemoglobin (hba1c) ≤10.5% * an estimated glomerular filtration rate (egfr) ≥60 ml/min/1.73m\^2 * subject with albuminuria exclusion criteria: * history of type i diabetes, pancreas or β-cell transplantation, or diabetes secondary to pancreatitis or pancreatectomy * serum potassium level \ 5.0 mmol/l * subjects who had acute kidney injury (aki) within 3 months prior to baseline or have undergone renal dialysis at any time prior to randomisation * subjects with a history of renal transplant * subjects with clinically significant hypotension

Keywords: diabetic nephropathy
simulation training for labor and delivery providers to address hiv stigma during childbirth in tanzania

Conditions: Hiv; Stigmatization; Pregnancy Related

Summary: this study will work in tanzania to develop and pilot test a simulation and experiential learning intervention for labor and delivery providers, in order to address hiv stigma during childbirth. the primary endpoint will be patient-rated changes in respectful maternity care, comparing women who deliver in the pre-intervention time period and women who deliver in the post-intervention period.

the study will pilot test the mama intervention in six clinics in the kilimanjaro region. 60 l\&d providers will be enrolled across the sites. patient level outcomes will be assessed using an interrupted time series design. approximately 206 participants will be enrolled (103 in the pre-intervention period and 103 in the post-intervention period). the primary outcome will be patients' reported experiences of respectful maternity care (rmc). secondary outcomes will be internalized hiv stigma, trust in health care, birth outcomes, hiv care engagements at 3 months, anticipated hiv stigma, and attitudes to long-term antiretroviral therapy. our enrollment targets (103 per condition) will allow for detection of a medium effect of 0.4 in the change of rmc overall scores with 80% power and α=0.05. pre- and post- surveys will be conducted for providers enrolled in the intervention, assessing outcomes related to practices of rmc, stigma toward wlhiv, self efficacy and clinical knowledge.

Eligibility criteria:
inclusion criteria: for labor and delivery providers: * over age 18 * employed by a study clinic * work in the labor and delivery ward for birthing women: * over age 18 * gave birth in a study clinic * diagnosed with hiv exclusion criteria: for labor and delivery providers: * has not provided clinical care in the labor and delivery ward in past 6 months for birthing women: * under age 18 * unconfirmed hiv status

Keywords: hiv stigma childbirth simulation training
acute rosuvastatin for preventing myocardial damage in patients with acs

Conditions: Acute Coronary Syndrome; Angioplasty

Summary: rosuvastatin reload may prevent myocardial damage in acs patients undergoing pci


Eligibility criteria:
inclusion criteria: * 18-75 year old * diagnosed as acute coronary syndrome * plan to pci exclusion criteria: * stemi patient * emergency pci(\<2h) for nste-acs * history of liver disease and myopathy (alt/ast\>3 x upper limit of normal,ck\>5 x upper limit of normal) * tg\>500mg/dl,ccr\<30ml/min * inflammatory disease * allergic to rosuvastatin * nephrotic syndrome,hypothyroidism,systemic lupus erythematosus,myeloma,et.al.

Keywords: rosuvastatin angioplasty acute coronary syndrome
survival of different core build-up materials

Conditions: Dental Prosthesis Failure

Summary: the purpose of this study is to compare three different core build-up materials for dental use. the study hypothesis is that there is no differences in survival rate of the different core build-ups.

core build-ups replace dental structures which are decayed through caries or tooth fractures. often there are necessary before insertion of dental restorations. in clinical practice, there are two main material groups: glass ionomer cements and composites. because of there good physical properties the composite materials claimed to fulfill the expected criteria of core build-ups. however, some of these composite core build-ups get lost before insertion of definite prosthetic restorations. the current prospective, randomized controlled study should investigate the survival rate of three different composite materials: "rebilda dc", "clearfil core dc / plus" and "multicore flow". the statistical analysis will performed with logistic regression performed by the institute of institute of medical biometry and informatics, university of heidelberg. the study hypothesis is that there is no differences in the survival rate.

Eligibility criteria:
inclusion criteria: * patients need a single crown or fixed dental prostheses * patients are able to signed inform consent form, more than 18 years, exclusion criteria: * no pregnant women * insufficient oral hygiene