Kornimate/medical-research-clean huggingface dataset:
comparison high-density silicone oils in retinal detachment

Conditions: Retinal Detachment

Summary: the purpose of the study is to compare the safety, intraocular adverse effects and the anatomic and functional outcome with two endotamponade silicone oil after a 3-month in complex inferior retinal re-detachments.

five to 10% of retinal detachments progressed to proliferative vitreoretinopathy (pvr), the common more cause of surgical failure of retina detachment. despite the use of internal tamponades, the treatment of retinal detachments due to a progressed proliferative vitreoretinopathy (pvr) is still a problem. at present, conventional silicone oil, having a lower specific gravity than water, is an excellent tool in advanced pvr retinal detachment especially of the upper circumference. in the past, to diminish the re-detachments diverse heavier-than-water density endotamponades were investigated by to use in in cases of inferior pvr. however,heavier-than-water density endotamponades have demonstrated adverse short term effects. (example: silicon dispersion: hypotension and inflammation) recently, two new long-term heavier-than-water internal tamponades were introduced: oxane hd \[oil-rmn3-mixture\] and densiron \[mixture of 30.5 vol% perfluorohexyloctane (f6h8) with 69.5 vol% polydimethylsiloxane (silicone oil)\], showing satisfying anatomical results and good intraocular tolerance. in the present study, we will compare the anatomical outcome, functional results and intraocular adverse effects of two types of heavier tamponades.

Eligibility criteria:
inclusion criteria: * patients complicated persistent retinal detachment due secondary to proliferative vitreoretinopathy exclusion criteria: * diabetes * uveitis * glaucoma

Keywords: retinal detachment proliferative vitreoretinopathy heavier-than-water internal tamponades
pain perception following computer-controlled vs. conventional dental anesthesia

Conditions: Pain Perception

Summary: this single-blind two-arm randomized control trial (rct) aims to evaluate the pain perception during and following administration of dental local anaesthesia using two different systems; i.e. computer-controlled (ccla) and conventional.

the administration of local anaesthesia (la) is associated with pain, fear and anxiety. computer-controlled la (ccla) aims to control the administration speed and reduce pain, fear and anxiety. this randomised control trial (rct) aims to compare the pain perception after ccla and conventional la, and it uses dental students as both test and operator group versus an experienced dentist as an additional operator of the la.

Eligibility criteria:
inclusion criteria: * dental students at the faculty of medicine, university of giessen enrolled in the course of local anaesthesia.
coronary disease morbidity and mortality in a population

Conditions: Cardiovascular Diseases; Coronary Disease; Myocardial Infarction; Heart Diseases

Summary: to study the entire population of olmsted county, minnesota, including all age categories, to examine the secular trends in coronary heart disease (chd) mortality, myocardial infarction (mi) incidence, and natural history, including mi severity, case fatality and post-mi morbidity. also, to examine the time trends in the prevalence of chd at post-mortem because of the uniquely high autopsy rate in olmsted county.

background: cardiovascular disease remains the leading cause of death in the u.s. despite an encouraging decline in age-adjusted coronary heart disease (chd) mortality, prevalent chd continues to represent a major health burden, particularly in the elderly population. most community surveillance programs, however, cannot fully characterize this problem because they are restricted to an upper age limit of 74 years and thus do not include the events occurring in an increasingly growing part of the population. observational studies have questioned the existence of a change over time in the prevalence of anatomic coronary disease either at post-mortem examination or at coronary angiography. this remains to be further examined in a population-based setting. in addition, the natural history of myocardial infarction (mi) in the reperfusion area is unknown; in particular, there are no population-based data on the incidence of post-mi heart failure. design narrative: the records of all olmsted county residents with a hospital discharge diagnosis of mi between 1979 and 1999 were reviewed, and standard epidemiologic mi validation criteria were applied; post-mi outcome over time was determined, including post-mi heart failure, angina, 30 day case fatality and long-term survival. in parallel with the analysis of time trends in chd mortality, the autopsy reports were reviewed to examine whether the prevalence of coronary disease at autopsy has changed over time. these studies provided an assessment of the clinical and anatomical manifestations of chd, including the outcome of acute mi, over a time period characterized by intensified primary prevention efforts and major changes in the treatment of acute chd. the study was renewed in july 2002 to continue surveillance of acute coronary heart disease events in order to address issues surrounding the diagnostic precision and risk stratification potential of troponin and high sensitivity c reactive protein (crp) and to monitor secular trends in severity and treatment modalities. novel approaches to the procurement of carefully timed blood samples allow direct measurement of the increase in number of cases of myocardial infarction using the new biomarker, troponin. an examination will be made of the prognostic value of quantitative peak troponin measured at 24 to 36 hours and high sensitivity c reactive protein measured early after symptom onset in the myocardial infarction cohort.

Eligibility criteria:
all residents of olmsted county, mn who are hospitalized and have an elevated troponin level.
trial to evaluate the ability of a single infusion of high-density lipoprotein (hdl) to modulate markers of cerebral ischaemia

Conditions: Stroke

Summary: the plasma concentration of high-density lipoprotein (hdl) can have anti-inflammatory, anti-oxidative and anti-thrombotic effects in addition to being able to remove cholesterol from peripheral tissues for secretion via the liver. the investigators hypothesise that elevation of plasma hdls will reduce the inflammatory response following removal of unstable atherosclerotic plaques in the carotid artery. such plaques can cause strokes and there is great benefit from early surgical removal, however such surgical procedures involve significant risks to the patient. the investigators propose infusing hdl into patients prior to removal of their unstable carotid plaque and measuring the changes in inflammatory responses in comparison to a similar placebo controlled group of patients.

following written informed consent, patients will be randomised to either the placebo or active arm of the study. bloods will be taken for baseline measurements, and the infusion of either saline (placebo) or rhdl (active agent) will be carried out on the ward. infusion will take 4 hours, and the active agent infused at 40mg/kg. just prior to cae, bloods will be collected (24 hours post-infusion) and the atherosclerotic tissue collected into rna stabilising agent for subsequent analysis. further bloods will then be collected 24 hours post-operatively (48 hours post-infusion). patients vital signs will be monitored hourly following infusion and will be reviewed in out-patients at 6 weeks after the operation.

Eligibility criteria:
inclusion criteria: * patients listed for elective carotid endarterectomy exclusion criteria: * pregnant women and women of childbearing age * patient with impaired renal function or liver function * patients sectioned under the mental health act

Keywords: atherosclerosis stroke ischaemia
transvaginal versus transobturator paravaginal repair

Conditions: Cystocele

Summary: clinical trial comparing the new technique for paravaginal repair versus the traditional technique

trial comparing the transobturator paravaginal repair versus the traditional technique

Eligibility criteria:
inclusion criteria: paravaginal defect cystocele midline and paravaginal defect cystocele exclusion criteria: * uterine descent previous cystocele surgery
clinical study on the treatment of mixed component cornea for high risk keratoplasty

Conditions: Corneal Transplantation

Summary: because of the immunologically privileged nature of the cornea, the graft rejection rate is less than 10% for low-risk keratoplasty. but when the cornea performed 2 or more quadrants of corneal neovascularization after ocular trauma or infection, the graft rejection rate is more than 65%, it is called high-risk keratoplasty. this study will observe the graft survival of high-risk corneal transplantation using mixed component cornea from different donors.

ocular trauma or infection lead to corneal limbal stem cell deficiency and central corneal opacification which could only be treated by central penetrating keratoplasty and limbal transplantation, but the rejection rate is very high. in clinical, we found that limbal transplantation combined with central penetrating keratoplasty from different donors can keep the graft transparent for a long time, this result also be found in organ transplantation, multiple donor organ transplantation could reduce rejection risk in liver and kidney transplantation. therefore, it is speculated that there are different mhc antigens from different donors, which cause different reactions after transplantation. because there are a large number of langerhans cells， abundant blood vessels and lymphatic in the limbal, so the rejection occurs early and severely. continuous and intense limbal rejection leads to the depletion of recipient t cells, lead to the immune tolerance of another donor's central corneal tissue. in this project, central penetrating keratoplasty and limbal transplantation from different donors will be carried out and the graft survival of high-risk corneal transplantation will be observed in clinical, to find a new method for high-risk corneal transplant patients.

Eligibility criteria:
inclusion criteria: * central corneal opacity involving full layer * corneal neovascularization in two or more quadrants * patients must be willing and able to return for scheduled follow-up examinations for 12 months after surgery * ages：18 -70 years exclusion criteria: * central corneal opacity not involving the endothelial layer * less than two quadrants of corneal neovascularization * history of stevens-johnson syndrome or sjogren's syndrome * severe eyelid and conjunctival scar * loss of vision in contralateral eye * pregnant and lactating women

Keywords: high-risk corneal transplantation penetrating keratoplasty limbal transplantation
family-based telemedicine vs. inpatient anorexia nervosa treatment (fiat)

Conditions: Anorexia Nervosa; Anorexia in Adolescence

Summary: the fiat study is funded by the innovationsfonds of the german ministry of health via the dlr project management agency. the study will be conducted in up to 21 hospitals across germany and in collaboration with 10 german public health insurance companies. the primary aim of this study is to compare family-based treatment delivered via telehealth (fbt) with inpatient multimodal therapy (imt) with respect to treatment outcomes and health economic data. the results of the study will serve as a basis for the decision on the inclusion of fbt in the german s3 guidelines and the future reimbursement of fbt by public health insurances in germany.


Eligibility criteria:
inclusion criteria: * restrictive and bulimic subtypes of anorexia nervosa (icd-10: f50.00; f50.01) * inpatient treatment indication according to s3 guideline * weight \< 3. bmi-percentile or * weight \<10. percentile and psychiatric comorbidity/rapid weight loss/lack of weight gain during outpatient treatment over last three month * planned inpatient treatment * insured with one of the participating health insurance companies * stable internet connection exclusion criteria: * weight \<67%mbmi * acute self harm or danger to others * acute psychosis or suicidal tendencies * current substance abuse * child abuse or domestic violence in the family * insured with other health insurance company * judicial placement order for inpatient treatment * known, currently existing child protection problems or proceedings by the family court

Keywords: psychotherapy family based treatment rct inpatient treatment
optimizing treatment programs for chronic kidney disease-mineral and bone disorder and malnutrition

Conditions: Vitamin D Deficiency; Malnutrition

Summary: multi-center, prospective, randomized, controlled study to verify the clinical effectiveness of k / doqi guidelines. the efficiency and safety of vitamin d2 and low protein diet treatment for prevention and treatment of ckd-mbd and malnutrition in ckd3-5 (nd) patients.

this study will enroll chronic kidney disease patients, stage 3 to 5nd, who have chronic kidney disease mineral and bone disease (ckd-mbd) and malnutrition as defined by kidney disease improvement global outcome (kdigo) guidelines. patients in five centers will be randomized. a total of 600 patients will be enrolled, 150 patients receiving vitamin d2 treatment virus 150 patients receiving calcitriol treatment, and another 150 patients receiving low protein diet virus 150 patients receiving normal protein diet. outcomes will be assessed as proportion of patients achieving target blood levels on calcium, phosphorus, parathyroid hormone, 25 hydroxyvitamin d, albumin and hemoglobin. other outcomes will also be assessed, which include secondary hyperparathyroidism (shpt), vascular calcification, cardiovascular diseases, nutritional status and quality of life.

Eligibility criteria:
inclusion criteria: * patients with age between 18-80 years. * patients with chronic kidney disease stage 3 to 5, and concurrent chronic kidney disease mineral and bone disorder and malnutrition exclusion criteria: * renal artery stenosis, inherent renal malformation, solitary kidney, or malignancy in urinary system. * active system immunity diseases. * history of liver failure * history of intestinal malabsorption or chronic diarrhea * treatment with phenobarbital, phenytoin, rifampicin, sucralfate, steroids, digoxin, or other medications that could affect vitamin d metabolism * primary hyperparathyroidism * treatment with cinacalcet or other calcimimetic within the past 6 months * anticipated dialysis within 6 months after randomization * have an unstable medical condition, defined as having been hospitalized within 30 days before screening, the expectation of recurrent hospital admissions or life expectancy of less than 6 months in the judgment of the investigator * subject is currently enrolled in, or fewer than 30 days have passed since subject has completed another investigational device or drug study(s); or subject is receiving another investigational agent(s). * current treatment with vitamin d 50,000 iu * using glucocorticoid or immunosuppressive agents. * acute renal dysfunction. * the expected live time is less than 2 years. * pregnant or lactating woman. * suffered from acute myocardial infraction, acute congestive heart failure, or stroke in last 6 months. * patients whose concurrent illnesses, disability, or geographical residence would hamper attendance at required study visit.

Keywords: chronic kidney disease mineral and bone disease malnutrition vitamin d low protein diet
pharmacokinetics of epinephrine during cardiac arrest

Conditions: Cardiac Arrest

Summary: to determine the pharmacokinetics of epinephrine during cardiac arrest.

the aim of out study is to determine the pharmacokinetics in humans during cardiac arrest, following a single dose of epinephrine. venous samples will be withdrawn every minute the first five minutes following a single dose. the aim of the study is to determine t1/2 in a clinical setting and to determine time to peak concentration.

Eligibility criteria:
inclusion criteria: * age 18-85 yrs * witnessed non-traumatic cardiac arrest. * probable cardiac origin * treated by bergen emergency medical services exclusion criteria: * terminal illness * residents of nursery homes * obvious dead * hypothermic patients * epinephrine administered before arrival of study physician

Keywords: epinephrine
brief treatment for posttraumatic stress disorder

Conditions: PTSD

Summary: the primary goal of this study is to examine whether a brief treatment approach for ptsd is equally efficacious in the treatment of active duty service members relative to a first line treatment approach that requires much greater treatment dose.

the goal of this randomized clinical trial is to investigate if a brief, written intervention for posttraumatic stress disorder (ptsd), written exposure therapy (wet), is non-inferior compared to an evidenced-based behavioral therapy, cognitive processing therapy-cognition only (cpt-c), in the treatment of ptsd in active duty military men and women with a diagnosis of ptsd who have deployed in support of a post-9/11. the primary study outcome is change in symptom severity as assessed by the clinician administered ptsd scale for diagnostic and statistical manual-5 edition (caps-5). independent assessors evaluated participants using the caps-5 at baseline, 10-, 20-, and 30-week after the first treatment session.

Eligibility criteria:
inclusion criteria: * male and female active duty military personnel who have deployed in support of a post-9/11 conflict seeking treatment for ptsd * diagnosis of ptsd * ability to speak, read and write english * not currently engaged in psychosocial treatment for ptsd * individuals taking psychotropic medications agree to work with their prescriber to remain on stable doses of any prescribed psychotropic medications for the duration of the intervention and through the first follow-up assessment as much as possible and as medically indicated. exclusion criteria: * current suicide or homicide risk meriting crisis intervention * active psychosis * moderate to severe brain damage
laughter yoga on pain and comfort in individuals diagnosed with migraine

Conditions: Pain, Head

Summary: in individuals diagnosed with migraine, laughter yoga will be performed for 45 minutes, 3 times a week for 1 month. the other application group will watch funny videos for 45 minutes, 3 times a week for 1 month.


Eligibility criteria:
inclusion criteria: * being older than 18 years of age * having been diagnosed with migraine for at least one year * having no mental disability exclusion criteria: * individuals using pain relievers * individuals who have done laughter yoga before

Keywords: laughter yoga, funny videos, migraine, pain, comfort
preservation of endopelvic fascia: effects on postoperative incontinence and impotence. randomized clinical trial.

Conditions: Prostatic Neoplasms; Urinary Incontinence; Erectile Dysfunction

Summary: urinary incontinence and impotence are typical disturbances after radical prostatectomy. although, several surgical methods are developed to decrease these disturbances, 8% and 50% of the patients suffer from permanent urinary incontinence and impotence, respectively. previously two studies have shown that endopelvic fascia preservation may decrease postoperative incontinence and impotence rates. unfortunately these studies are retrospective decreasing their reliability. the present study is prospective and randomized clinical trial. the investigators are going to randomize 180 patient to preservation and opening the endopelvic fascia groups. functional and oncological results are followed up to 1 year after surgery.

180 patients going to radical prostatectomy as treatment of prostate cancer will be randomized 1:1 to two study arms: in the other arm endopelvic fascia are preserved during the operation, in the other arm the fascia are opened. after the operation urinary continence and erection function are compared between the study arms. additionally the investigators will study oncological outcomes.

Eligibility criteria:
inclusion criteria: * localized prostate cancer * planned nerve-sparing robotic radical prostatectomy * gleason score 7 or less exclusion criteria: * previous prostate surgery (turp, tuip, laser...) * planned lymphadenectomy * t3 cancer
tiotropium in patients with tuberculosis (tb) destroyed lung

Conditions: Lung Disease, Obstructive; Tuberculosis

Summary: the aim of this study to evaluate clinical efficacy of tiotropium in patients with airflow obstruction due to tuberculosis (tb) destroyed lung.

tuberculosis can cause lung parenchymal destruction, volume loss, secondary bronchiectasis. patients with tb destroyed lung complain chronic respiratory symptoms, such as chronic cough, sputum, dyspnea, exercise intolerance, and acute exacerbations. some of them have chronic airflow obstructions on pulmonary function tests, similar to those of smokers. previous large randomized controlled trials, targeting patients with smoking related moderate to severe copd,demonstrated that tiotropium improved quality of life and respiratory symptom with tolerable long-term safety. the investigators want to evaluate whether tiotropium can improve chronic respiratory symptom,an lung function in patients with copd due to tb destroyed lung.

Eligibility criteria:
inclusion criteria: * previous pulmonary tuberculosis history * never smoker or light smoker (\<10 pack-year) * destruction of lung parenchyme, lung volume loss,secondary bronchiectasis due to tuberculosis in chest radiographs or chest ct, confirmed by board-certificate radiologist * airflow obstruction confirmed by pulmonary function test, fev1/fvc \<70% exclusion criteria: * patients do not agree with study enrollment * patients with active tuberculosis or current antituberculous medication * patients under chemotherapy or other immunosuppressant therapy such as glucocorticoid. * active infection such as pneumonia, tuberculosis * patients who are illiterate * patients with dementia * pregnant or to be pregnant * previous lung resection surgery history

Keywords: copd tiotropium tuberculous destroyed lung
a trial investigating the influence of injection speed and volume on the perception of subcutaneous injection pain

Conditions: Diabetes Mellitus

Summary: a trial, investigating the influence of injection speed and volume on the perception of subcutaneous injection pain.


Eligibility criteria:
inclusion criteria: * subject has signed the informed consent form prior to screening * age 18-74 years at screening (both included) exclusion criteria: * known or suspected hypersensitivity to needle, ink ball pen or other that are in contact with the injection area during the clinical visit * previous participation in this trial. participation is defined as having received at least one injection
de-escalation protocols in hpv-related oropharyngeal carcinoma in chinese populations

Conditions: Oropharyngeal Carcinoma; De-escalation

Summary: human papillomavirus (hpv)-related oropharyngeal carcinoma are exquisitely radiosensitive. several studies attempted to reduce the toxicities of treatments through reduced-dose radiation and showed promising results, but all data were collected from non-chinese areas. like nasopharyngeal carcinoma, oropharyngeal carcinoma may have different biological behavior and relationship with hpv infection. so the investigators studied whether toxicities reducing treatment with reduced radiation dose and omitted concurrent chemotherapy after good response to induction chemotherapy would maintain survival outcomes while improving tolerability for patients with hpv-positive oropharyngeal carcinoma.


Eligibility criteria:
inclusion criteria: * histological diagnosis of squamous cell carcinoma of oropharynx with ihc p16 positive or pcr hpv16 positive * t1-2/n1-3m0（except t1n1m0 and single ln\<3cm）or t3-4n0-3m0 according to uicc/ajcc 8th staging system * age ≥18 * no prior anti-tumor treatment * karnofsky performance score (kps)≥70 * adequate blood supply * informed consent obtained exclusion criteria: * cannot take contrast-mri imaging * pregnant * combined with other malignant tumor (except basal cell carcinoma of skin)