Kornimate/medical-research-clean huggingface dataset:
does splinting prevent contractures following stroke?

Conditions: Cerebrovascular Accident

Summary: after a stroke, many people develop contracture of the muscles in their affected wrist and hand which leads to a permanently clenched, painful hand. a contracture is often treated by therapists who use hand splinting to prevent it occurring or slow down its progression. despite their wide use, there has not been research completed to investigate whether or not splinting prevents contracture in people following stroke. in fact, this project will be the first of its kind in the world and is therefore vital to stroke rehabilitation. the study is a multi-centre, randomised controlled trial that will measure the effect of hand-splinting in two positions on the prevention of contracture, functional use of the hand, and quality of life.


Eligibility criteria:
inclusion criteria: * first ever stroke * score of \<1 on motor assessment scale item 6 exclusion criteria: * comorbidity resulting in previous contracture of the wrist/hand

Keywords: splints occupational therapy
rho kinase (rock) inhibition in carotid atherosclerosis

Conditions: Carotid Stenosis

Summary: to evaluate the causal relationship between rho/rho kinase overactivity and mechanisms of vascular dysfunction in patients with atherosclerosis.


Eligibility criteria:
inclusion criteria: * subjects with \>= 70% carotid stenosis (unilateral or bilateral) who are scheduled to undergo elective carotid endarterectomy * age \>= 18 years * agreement of the operating surgeon for patient to participate exclusion criteria: * surgery scheduled \< 14 days after randomization * pregnancy * alt, ggt \> 3x upper limit of normal (uln) * creatinine \> 3.5 mg/dl * prior intolerance to statins * reluctance to add or change dosage of statin therapy during study

Keywords: patients scheduled for elective carotid endarterectomy
optimom grows up: 5.5-year follow-up of the optimom fortifier study

Conditions: Infant, Very Low Birth Weight

Summary: in canada, the leading cause of long-term disability in children is being born at very low birth weight (vlbw). to help improve outcomes, nutrition is a modifiable aspect of infant care. mother's milk is the optimal way to feed vlbw infants; however, many need a supplement of donor milk or preterm formula as not enough mother's milk is available. as the ideal supplement for prolonged feeding and its long-term effects is currently unknown, this study is a prospective follow-up of infants born vlbw who were fed mother's own milk or pasteurized donor breastmilk nutrient enriched with a human milk-based fortifier or a bovine protein-based fortifier. intakes of donor milk, fortifier type, macronutrients and fatty acids will be explored. areas of development to be assessed include: cognition, language, motor skills, and body composition. this study will also cross-sectionally examine aspects of eating behaviours, food parenting and the home environment (e.g., stress, home chaos, family functioning) with a term-born comparison. a dna biorepository will also be created.


Eligibility criteria:
inclusion criteria: * children who were enrolled in the bovine vs. human milk-based fortifier study (nct02137473) * children who were born \>=37 weeks gestation and weighing \> 2500g \[term-born comparison group\] exclusion criteria: * for term-born comparison only: a child with any chromosomal or congenital anomaly affecting growth
phenotype evaluation in insulin naive patients using lantus (insulin glargine)

Conditions: Type 2 Diabetes

Summary: primary objective: * efficacy assessment of the percentage of positive responders patients receiving lantus plus glucophage association. positive responders patients are defined by a final value of hba1c\ 15% compare to the basal value (hba1c final - hba1c basal). secondary objectives: * determination of the predictive criterion of hba1c final, * determination of the predictive criterion of weight variation, * description of the glycemic and therapeutic criteria in the both groups of responders (positive and negative responders), * assessment of the lipidic parameters according to the hba1c and weight changes during the study (final value - basal value). safety: * adverse event (ae)/serious adverse event (sae) assessments


Eligibility criteria:
inclusion criteria: * known type 2 diabetes for at least 2 years * no history of ketoacidosis * bmi\> 25 \& \<35 kg/m2 * type 2 diabetes treated with oral bi or tritherapy for at least 6 months * with insulin release stimulator: sulfonamide or glinide at maximal posology (as defined in the smpc), * and metformin at minimal posology 1700mg/day (1320 mg of metformin), * hba1c \>= 7.5 and \<11% for 2 different dosages during the last year exclusion criteria: * type 1 diabetes * glucophage intolerability * pregnancy * breast feeding * partial pancreatectomy * hypersensitivity to insulin glargine excipient * renal failure with creatinin\>135 µmol/l for male and \>110 µmol/l for female patient * hepatitis with transaminases \>3uln * pre-proliferative or proliferative retinopathy * acute cardiovascular accident within the last 6 months * previous treatment with insulin within the last 6 months before randomization
enhancing participation of chronic stroke patients by constraint induced movement therapy (homecimt)

Conditions: Stroke

Summary: the aim of this study is to evaluate the efficacy of a modified approach of constraint induced movement therapy ("cimt at home") for chronic stroke patients, compared to conventional physiotherapy and occupational therapy ("therapy as usual) with regard to the ability to participate in everyday activities.

the study is a parallel cluster randomized controlled trial with therapy practices as clusters. after written consent from the patients, the therapists are randomly assigned to treat either the intervention or the control group. blinded external assessors evaluate the patients using standardized outcome measures before and after the intervention, and six months later. the two coprimary endpoint assessments of arm and hand function as prerequisites for participation (defined as equal involvement in activities of daily living) are quality of arm and hand use and arm and hand function. assessments are made four weeks post-treatment and relativized to baseline performance. changes in primary outcomes are analyzed with mixed models, which consider the hierarchical structure of the data, adjusted to the baseline measurements and sex. the primary analysis compares the two randomized groups, with respect to the adjusted averages for each of the two coprimary endpoints. to keep an overall significance level of 5%, the two endpoints are tested at the significance level of 5% each in hierarchical order.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * stroke onset \> 6 months prior to study enrollment * upper extremity hemiparesis with impairment of hand and/or arm * minimal function of the hand (at least 10º active wrist extension, at least 10º active of thumb abduction/extension, and at least 10º of extension two additional fingers) * non-professional coach (e.g. family member) * prescription of physical or occupational therapy exclusion criteria: * lack of knowledge of german * serious impairment of verbal communication ability (e.g. severe aphasia) * inability to consent (e.g. dementia) * severe neuro-cognitive deficits (mmse \<23) * terminal illness, life-threatening co-morbidity * simultaneous participation in another treatment study targeting stroke recovery * subjects may not have already received constraint induced movement therapy

Keywords: stroke constraint induced movement therapy participation physical therapy occupational therapy
pilot study: comparison of patients' knowledge of direct oral anticoagulants in post-hospitalization between 2 cardiology departments offering or not a pharmaceutical interview during hospitalization

Conditions: Atrial Fibrillation; Deep Vein Thrombosis; Pulmonary Embolism

Summary: direct oral anticoagulants (rivaroxaban, apixaban and dabigatran) are an alternative to anti-vitamin k drugs and low molecular weight heparins in many cardiovascular diseases. this new class of anticoagulants represents a particular and very promising advance: they are administered orally, their mechanism of action is rapid and direct on coagulation and their predictable pharmacological action allows for administration at fixed doses. in contrast to anti-vitamin k, there is no need for routine biological monitoring. however, their therapeutic range is narrow and there is no routine biological monitoring. rigorous compliance is therefore necessary. in addition, there are no official validated recommendations either for the measurement of anticoagulant activity in certain emergency situations, or for the management of severe bleeding (except recently for pradaxa®). their correct use requires the training and involvement of health professionals as well as information and support for patients. pharmaceutical interviews are one of the main ways in which pharmacists can ensure this security through personalized and optimal patient care. the purpose of these interviews is to: * reinforce the pharmacist's advisory, educational and preventive roles with patients; * to enhance the pharmacist's expertise in the area of medication; * to evaluate the patient's knowledge of his or her treatment; * to assess the patient's knowledge of his or her treatment; to seek the patient's therapeutic adherence and help him or her to take ownership of his or her treatment; * to evaluate, in the long term, the patient's appropriation of his or her treatment. in this way, they enable involvement with patients while providing a link between healthcare professionals, which is essential for optimal patient care. in recent years, numerous studies have been conducted on pharmaceutical interviews in the united kingdom and the netherlands. on the other hand, few studies have been conducted in france to evaluate the clinical impact of pharmaceutical interviewing in medical services. the aim of this study is to compare patients' knowledge of direct oral anticoagulants between 2 cardiology departments offering or not a pharmaceutical interview.


Eligibility criteria:
inclusion criteria: * patient hospitalized for more than 48 hours in a cardiology department with a discharge prescription for curative anticoagulation. * indication for a direct oral anticoagulant for atrial fibrillation, deep vein thrombosis or pulmonary embolism exclusion criteria: * patients treated for the prevention of venous thromboembolic disease who have undergone scheduled total hip replacement or total knee replacement surgery. * patient with cognitive impairment * patients with a previous prescription for a direct oral anticoagulant

Keywords: direct oral anticoagulants
the effect of self-regulatory education on women with asthma

Conditions: Asthma

Summary: the project evaluates an innovative educational intervention using telephone counseling based on self-regulation theory designed to address a problem heretofore overlooked in asthma self-management education: the unique needs of adult female patients.

background: more than half of the adults with asthma in the us are female. prevalence of asthma in women appears to be increasing, and morbidity and mortality rates for this group are significantly higher than rates for men. recent studies point to unique features in women's management of asthma potentially attributable to gender. these include, for example, factors associated with hormonal cycles, (e.g. menses, pregnancy, menopause) and social roles (e.g. household tasks exposing one to environmental triggers, caregiving to children and relatives interfering with asthma management etc.) to date, no rigorously evaluated intervention expressly designed for women with asthma has been reported in the literature. design narrative: this study is to assess the effectiveness of a gender-specific telephone counseling, self-regulation intervention for women with asthma. to test our hypothesis we employed a randomized controlled design utilizing an intervention group and a control group. the primary outcomes are gender-related asthma management problems, health care utilization, days having symptoms, self-regulation level, management skill, and quality of life. we measure at three time points: baseline before randomization; follow-up i, one year subsequent to randomization; and follow-up ii, one year subsequent to follow-up.

Eligibility criteria:
the study participants are a noninstitutionalized ambulatory sample of women who are willing to participate in the project and meet the following criteria: 1. 18 years of age or older, 2. a diagnosis of asthma, 3. presence of active symptoms, 4. enrolled as a patient in one of the university of michigan medical center asthma-related clinics, 5. listed as having received face-to-face instructions by clinic personnel on peak flow monitoring and proper use of medicine and delivery devices, and 6. not pregnant. women who are found to have extenuating circumstances that would prevent them from fully benefiting from the program (e.g., mental illness or terminal illness) are excluded.
efficacy of a modified technique of free gingival graft in volumetric changes of the graft: randomized clinical trial

Conditions: Gingival Recession

Summary: this study will compare a new technique of free gingival graft to the original one, in order to evaluate the stability of the graft volume over one year and other variables. twenty patients will receive the original technique of free gingival graft (controls) and twenty patients will receive the modified technique, in which the free gingival graft is submerged (tests), at the inferior incisors area.

the free gingival graft surgery is held to gain some keratinized tissue in areas where it has been lost, such as in inferior incisors with gingival recessions. in these areas, tooth brushing may become harder and painful, negatively influencing in plaque control. however, this type of graft seems to contract over time. a new approach of free gingival graft, in which the graft is covered by a flap, promises to provide greater vascularization. this would promote less graft contraction and better mucosal color. forty patients with less than 2 mm of keratinized tissue (measured from gingival margin to mucogingival junction) in at least one inferior incisor will be included. half will receive the original technique and half will receive the modified one. patients will be followed at 7, 14, 21, 28, 42 days, 3, 6, 12 months and 8 years after surgeries.

Eligibility criteria:
inclusion criteria: * reduced keratinized tissue (less than 2 mm) in inferior incisors area * healthy periodontium in inferior incisors area * indication for surgery (e.g. pain during tooth brushing, gingival margin mobility, gingival recession...) * recessions class i, ii or iii, maximum 3 mm * having signed the informed consent exclusion criteria: * systemic diseases * smokers * pregnant and lactating women * root caries lesions * previous surgeries at same area * accentuated root abrasion * malpositioning teeth * residual pocket depths greater than 4 mm * tooth mobility greater than 1

Keywords: free gingival graft keratinized gingival tissue
the effect of anterior corneal incisions on intraoperative floppy iris syndrome (ifis) incidence and severity in tamsulosin treated cataract patients

Conditions: Intraoperative Floppy Iris Syndrome

Summary: intraoperative floppy iris syndrome (ifis) may occur during cataract surgeries in patients treated with alpha 1 blockers. ifis related to alpha 1 blocker tamsulosin (used for prostate hypertrophy) was reported in 50-90% of patients. ifis during surgery make the surgery more difficult and raise complication rate. using anterior corneal incisions was reported briefly in literature as a prophylactic means but was not studied prospectively. we believe (according to our clinical experience) that these anterior incisions do help to reduce the incidence and severity of ifis signs and complications rate during surgeries.


Eligibility criteria:
inclusion criteria: 1. cataract candidates treated (in the present or in the past) with tamsulosin 2. aged 55 or more 3. candidates for topical anesthesia 4. no allergy to anticholinergic or adrenergic drugs 5. able to understand and sign an informed consent exclusion criteria: 1. history of uveitis 2. iris neovascularization 3. s/p iris surgery 4. traumatic/uveitis induced cataract 5. dialysis / abscence of zonules

Keywords: ifis
cyanotic heart disease and thrombosis

Conditions: Thrombosis

Summary: the purpose of the study is to examine previously examined patients with cyanotic congenital heart disease to assess how many of the patients have obtained additional blood clots since they were examined 8 years ago.

patients with cyanotic congenital heart disease have reduced oxygen content in their blood due to abnormal connection between the heart's right and left sides. the reduced oxygenation of the blood affects several organs of the body and a common complications to the disease is blood clots. despite the patients are young and do not have typical risk factors, previous studies have shown, that they have a very high prevalence of thrombosis in the lungs and brain. the reason for the increased prevalence of blood clots is not known. a previous study investigated the prevalence of blood clots systematically in patients with cyanotic congenital heart disease and found that approximately 30-40% of the patients had had a clot in the lung or brain. thus, the study could not predict, when the patient had had a thrombotic event, and most of the patients did not previously had imaging performed. therefore the aim of this study is to re-examine previously examined cyanotic patients regardless of previous medical history, to assess how many of the patients have obtained additional blood clots since they were examined 8 years ago.

Eligibility criteria:
inclusion criteria: * patients with cyanotic congenital heart disease who have previously participated in the study 'cyanotic congenital heart disease: hemostatic abnormalities and clinical manifestations' (h-kf-2006-4068). * clinically stable exclusion criteria: * patients who are not guardians for themselves (not adult). * age \<18 years.

Keywords: cyanotic congenital heart disease pulmonary thrombosis cerebral thrombosis
comparison of the effects of bilateral transversus abdominis plane block and bilateral quadratus lumborum block on postoperative analgesia in patients undergoing midline laparotomy

Conditions: QLB vs TAPB; Quadratus Lumborum Block; Transversus Abdominis Plane (TAP) Block

Summary: midline incisions provide easy, rapid and excellent exposure of the abdominal cavity and are particularly used for complex, diagnostic or emergency procedures. however, midline incisions transect the nerve fibers passing in the mediocaudal direction of the abdominal wall, which causes more postoperative pain than other incisions. postoperative pain and delayed return of bowel function are thought to be the main factors that prevent early recovery and discharge. or surgical procedures where parietal pain is the main component of postoperative pain, tapb can be used as a simple and effective analgesic technique with the added advantage of preserved motor and bladder function. quadratus lumborum block can be used as an analgesic technique in all surgeries such as proctosigmoidectomy, hip surgery, above-knee amputation, abdominal hernia repair, breast reconstruction, colostomy closure, radical nephrectomy, lower extremity vascular surgery, total hip arthroplasty, laparotomy and colectomy. our study aimed to compare the effects of bilateral oblique subcostal tapb with bilateral qlb2 and qlb3 performed under ultrasound guidance in midline incision laparotomies on total opioid requirement in the first 24 hours postoperatively, early postoperative pain intensity, time to first rescue analgesic requirement, nausea, vomiting and pruritus. to evaluate this hypothesis, we compared tapb and qlb in a prospective, randomized, single-center clinical study. the primary endpoint of our study was the comparison of total morphine consumption in the first 24 hours postoperatively.


Eligibility criteria:
inclusion criteria: * laparotomy with midline incision * general anesthesia will be applied * 18-70 years old * asa 1-3 * bmi of 18-30 kg/m2 * literate * without cognitive impairment * patients who approved the informed consent form exclusion criteria: * under 18 years old * over 70 years old * asa 4 and above * cognitive impairment * i̇lliteracy * vision and hearing problem * infection at the injection site * coagulopathy * peripheral neuropathy * local anesthetic allergy * patients who do not want to be included in the study

Keywords: oblique subcostal transversus abdominis plane block quadratus lumborum block pain regional anaesthesia
transcorneal electrical stimulation therapy for retinal disease

Conditions: Retinitis Pigmentosa; Macula Off; Primary Open Angle Glaucoma; Hereditary Macular Degeneration; Treated Retina Detachment; Retinal Artery Occlusion; Retinal Vein Occlusion; Non-Arthritic-Anterior-Ischemic Optic-Neuropathy; Hereditary Autosomal Dominant Optic Atrophy; Dry Age Related Macular Degeneration; Ischemic Macula Edema

Summary: transcorneal stimulation may enable neurons to survive degeneration processes via enhanced secretion of neurotrophic substances and direct stimulation of neurons.


Eligibility criteria:
inclusion criteria: * retinitis pigmentosa, macula off, primary open angle glaucoma, hereditary macular degeneration, treated retina detachment, retinal artery occlusion, retinal vein occlusion, non-arthritic-anterior-ischemic optic-neuropathy, hereditary autosomal dominant optic atrophy, dry age-related macular degeneration, ischemic macula edema exclusion criteria: * severe other disease such as non-proliferative diabetic retinopathy, exudative age-related macular degeneration * age above 99 years

Keywords: retinitis pigmentosa macula off primary open angle glaucoma hereditary macular degeneration treated retina detachment retinal artery occlusion retinal vein occlusion, non-arthritic-anterior-ischemic optic-neuropathy hereditary autosomal dominant optic atrophy dry age-related macular degeneration ischemic macula edema
greek physicians perceptions regarding generics prescribing in glaucoma

Conditions: Glaucoma

Summary: this attempts to investigate the perceptions of greek ophthalmologists regarding generics prescription in glaucoma by means of a structured questionnaire.

the following dimensions will be recorded 1. overall physician's empathy regarding generics in glaucoma 2. physician's prescribing habits regarding generics in glaucoma 3. physician's perceptions regarding generics cost-effectiveness in glaucoma 4. physician's perceptions regarding adequacy of greek regulatory authorities (generic market in glaucoma) 5. physician's perceptions regarding adequacy of european regulatory authorities (generic market in glaucoma)

Eligibility criteria:
inclusion criteria: licensed registration to greek ophthalmology council exclusion criteria: -

Keywords: greece ophthalmology glaucoma generics perception