Kornimate/medical-research-clean huggingface dataset:
closed suction drain or not after total hip arthroplasty

Conditions: Total Hip Arthroplasty

Summary: comparative randomised study to clarify which better to use or no use of closed suction drain system after total hip arthroplasty regarding amount of blood loss, need for blood transfusion, risk for superficial infection, ecchymosis, wound discharge, effect on early post-operative rehabilitation. patients will be followed up for one month postoperative clinically (harris hip score system), laboratory (hb level), and radiologically (a-p view plain x-ray of the hip).

total hip arthroplasty (tha) wounds are prone to formation of hematomas. hematomas may increase the incision tension, leading to wound discharge and providing a good medium for bacteria, increase post-operative pain, limitation of range of motion of hip joint and prolong post-operative rehabilitation duration, also may cause ecchymosis, and tension vesicles around the surgical wound. so use of closed suction drain system may reduce these complications. nevertheless some recent studies have claimed that drainage can cause other complications and does not reduce hematoma formation and risk for infection. furthermore, some studies have shown that drainage increase blood loss after tha which may both lead to increase blood transfusion requirements and provide an entry point for skin microorganisms. some other studies have found that no significance between use and non use of suction drain after tha. so the investigators will take this issue for study a comparison between benefits and hazards of use and non use of suction drain after tha.

Eligibility criteria:
inclusion criteria: * primary total hip arthroplasty (tha) exclusion criteria: * revision cases * uncontrolled bleeding tendency (prothrombin conc. less than 70%) * history of deep venous thrombosis * sever liver impairment (liver failure) * sever renal impairment (s. creatinine more than 3)

Keywords: closed suction drain wound hematoma
cognitive stimulation therapy for dementia: a two-armed pragmatic trial

Conditions: Dementia; Cognitive Impairment, Mild; Dementia, Vascular; Dementia, Mixed; Dementia With Lewy Bodies; Dementia Frontal; Dementia Moderate; Dementia of Alzheimer Type; Dementia, Mild

Summary: cognitive stimulation therapy (cst) is an evidence-based non-pharmacological group therapy shown to benefit people with mild to moderate dementia. despite increasing availability of cst worldwide, access remains limited in the united states. this pilot pragmatic trial will embed cst referral into the standard care protocol of health care settings that serve people living with dementia in the state of connecticut, and evaluate online delivery of cst known as virtual cst (v-cst), and assess the acceptability of v-cst to people living with dementia. the study design is a two-armed randomized embedded pragmatic clinical trial (epct). the trial aims to determine if cognitive decline is experienced less commonly among v-cst participants than control group members based on three widely used measures of cognition, the montreal cognitive assessment (moca), st. louis university memory screen (slums), and mini mental state exam (mmse). the study population will be persons with mild to moderate dementia identified by clinicians in standard care. from this population, subject participants will be randomized to intervention and control groups. patients randomly assigned to the intervention group will be referred by their clinical providers to participate in v-cst, and those who accept the referral will participate in the intervention.


Eligibility criteria:
inclusion criteria: * diagnosis of mild cognitive impairment or mild to moderate dementia * moca score of 10 to 26 or slums score of 10 to 26 or mmse score between 13 and 24 recorded as present \< 24 months before the record review * english-speaking * visit scheduled to include cognitive screening 6 to 12 months after record review. exclusion criteria: * auditory or visual impairment, combative behaviors, or other clinician-assessed condition that would interfere with group treatment * no access to online meeting platform * patient has specified to hcs not to engage patient in research or to use patient data in research * patient has previously participated in v-cst * physician determines a caregiver is needed to support v-cst participation, but no caregiver available to assist with technology.
effect of cv4 and rib raising techniques on autonomic balance

Conditions: Autonomic Nervous System Disease; Osteopathy

Summary: background. heart rate variability (hrv) and skin conductance (sc) highlight autonomic activity and the balance of autonomic nervous system (ans) which regulates involuntary physiological functions. the modulation of ans tonic activity is a target of osteopathic manipulative treatment (omt). the main aim of the present study was to verify whether cv4 and rr osteopathic techniques influence ans activity. trial design. a randomized-controlled clinical trial was performed from june 2010 to january 2011. methods. 32 healthy adults were selected. at enrollment, all healthy subjects were randomized in three groups: cv4 group (cv4 technique), rib raising group (rr technique), and placebo group (pl technique). hrv and sc was recorded during the session respectively with heart rate monitor polar s810i and with onda scanner domiana (osd-microsale model). all data analysis was performed using spss statistical software and the significance level set at p≤0.05.


Eligibility criteria:
inclusion criteria: * healthy subjects * between 18-65 years old * both gender exclusion criteria: * bmi ≥ 30 * pregnancy * menstrual flow during the session * chronic pain * chronic drug treatment * presence of skin, cardiovascular, psychiatric and neurological diseases * medical history of surgical interventions * omt in the previous 3 months

Keywords: heart rate variability autonomic nervous system osteopathic manipulative treatment skin conductance
the effect of ketogenic diet versus mediterranean diet in patients with obesity and psoriatic arthritis

Conditions: Obesity and Psoriasis

Summary: the aim of our study is to compare the effectiveness of mediterranean diet (md) with the isocaloric ketogenic diet (kd) on clinical and biochemical markers of inflammation in patients with obesity, psoriasis (pso) and psoriatic arthritis (psa).

overall, twenty patients with body mass index (bmi) \>30 kg/m2, pso and psa under constant systematic treatment for at least 3 months will be included in the study. they will randomly assign to two groups, starting either with md or kd for a period of 8 weeks. after a 6-week washout interval, the two groups will cross over to the other type of diet for the same 8-week period. the primary endpoint is the change in psoriasis area and severity index (pasi) and the disease activity index for psoriatic arthritis (dapsa) score, 8 weeks after each diet intervention. secondary endpoints are changes in biochemical markers of inflammation (il-6, il-17, il-22, il-23) , in metabolic and anthropometric parameters.

Eligibility criteria:
inclusion criteria: 1. age above 18 years 2. body mass index (bmi) \>30 kg/m2 3. diagnosis of psoriasis and psoriatic arthritis under constant systematic treatment with biologic agents and/or synthetic disease-modifying anti-rheumatic drugs (dmards) for at least 3 months. 4. δpasi score\ 3 swollen \&\> 3 tender joints ή dapsa\< 14). exclusion criteria: 1. participation in another study 2. egfr\<60ml/min/1.73m2 3. malignancy 4. severe hepatic disorder 5. hba1c\>10% 6. use of glucagon-like-petide-1 analogues
a prospective randomised multi-centre trial comparing cardiac mri guided crt versus conventional crt implantation in patients with ischaemic cardiomyopathy

Conditions: Cardiovascular Diseases

Summary: the purpose of the study is to determine whether mri guided crt implantation (using siemen's software prototype) is superior to standard treatment in terms of crt response. data will be collected at enrolment, implant, pre-discharge, 6 weeks and 6 months. the total duration of the investigation will be 6 months. the primary endpoint will be assessed by calculating the difference in the proportion of responders (\>15% reduction in end systolic volume derived from 2-dimensional transthoracic echocardiogram at 6 months post crt implant).


Eligibility criteria:
inclusion criteria: * \>18yrs of age * standard indication for crt-p or crt-d according to european society of cardiology (esc)/european heart rhythm (ehra) guidelines.1 * stable on optimal medical therapy for at least 3 months * ischaemic aetiology * patients with atrial fibrillation can be included exclusion criteria: * any contraindication to pacing /implantable cardioverter-defibrillator (icd) implant * requirement for endocardial pacing * contraindication to gadolinium contrast enhanced cardiac magnetic resonance (mr) scanning * significant claustrophobia * significant renal impairment with estimated glomerular filtration rate (egfr) \<30 ml/min/1.73m2 * existing pacemaker or icd system or extraction of a crt system within the last 6 months * participation in other studies with active treatment/ investigational arm * pregnant or planning to become pregnant in the next 7 months
prevention of retinal non-perfusion in central retinal vein occlusion by hydroxycarbamide treatment.

Conditions: Central Retinal Vein Occlusion, Non-Ischemic

Summary: the central retinal vein occlusion (crvo) is a major cause of ocular morbidity, depending in particular on the occurrence and extent of retinal ischemia by capillary occlusion. there is no effective systemic treatment of this condition. an increase in the adhesion of erythrocytes to vascular endothelium was observed for patients with crvo, correlated with overexpression of membrane phosphatidylserine

introduction : the central retinal vein occlusion (crvo) is a major cause of ocular morbidity, depending in particular on the occurrence and extent of retinal ischemia by capillary occlusion. there is no effective systemic treatment of this condition. an increase in the adhesion of erythrocytes to vascular endothelium was observed for patients with crvo, correlated with overexpression of membrane phosphatidylserine. hypothesis : hydroxycarbamide (hc) by reducing the erythrocyte adhesion to the endothelium may prevent or delay the onset of retinal capillary non-perfusion in patients with crvo. primary objective: to assess the efficacy at 3 months of treatment with hc on retinal capillary perfusion in patients with a recent crvo. secondary objectives: to evaluate the safety of the treatment, the efficacy to 6 months on retinal perfusion of the treatment with hc (hc peak effect on the red cell adhesion in vitro), and the biological effects of hc, in particular on adhesion to endothelium and erythrocyte hemorheological parameters.

Eligibility criteria:
inclusion criteria: * patients of both sexes of at least 45 years of age. * with social protection * presenting crvo for less than 1 month duration * with a decrease of visual acuity and with the best corrected visual acuity lower than 6/10 (73 etdrs letters) * signature of informed consent exclusion criteria: * predictable lack of compliance to the protocol * monophtalmic patient or any ocular history or condition that could interfere with the study course or results interpretation. * active systemic disease * sickle cell disease * myeloproliferative disease * myelosuppression * kidney or liver insufficiency * ongoing treatment with hydroxycarbamide or anticoagulant * pregnancy, breast-feeding, no efficient contraception (for both sexes) * wish of paternity (for males of al least 45 years of age)
an open label extension of a study comparing topiramate and amitriptyline in migraine prevention.

Conditions: Migraine

Summary: the purpose of this study is to assess the long-term safety and effectiveness of topiramate for the prevention of migraine headaches in adults. topiramate has been approved to prevent migraine headaches in adults.

migraine headaches can be disabling and can interfere with work and a person's quality of life. preventing these headaches before they start is the best option. topiramate, an anti-seizure medication, has been shown to help prevent migraine headaches from occurring. this is an open-label study that is an extension of a previous study (capss-277) comparing topiramate and amitriptyline in migraine prevention. it includes patients who completed the previous study and elected to enter open label treatment with topiramate. the study will involve a 4-week blinded transition phase during which patients will be titrated up to a daily topiramate dose of 100 milligrams (or the maximum tolerated dose, whichever is less). then there will be a 12-week open-label maintenance phase during which the topiramate dose may be adjusted according to effectiveness and tolerance, but not to exceed a daily dose of 400 milligrams. while on topiramate, patients will record daily entries in their headache records. patients will be asked questions to help assess their quality of life. patients will also have physical examinations and laboratory tests performed during the study. the objective of this study is to evaluate the long-term safety and effectiveness of topiramate for the prevention of migraine headaches. topiramate oral tablets, 25 milligrams per tablet, will be given in the morning and evening to a dose not to exceed 400 milligrams per day or to the maximum tolerated dose, whichever is less

Eligibility criteria:
inclusion criteria: * diagnosis of migraine with or without aura * successfully finished capss-277 study * in generally good health * able to take medicine orally * if female, using birth control exclusion criteria: * not having a more painful condition than the headache pain * cannot be taking any other medications not allowed by the study * abnormal liver tests * not compliant with study medication during the capss-277 study * pregnant or breast-feeding

Keywords: chronic headache prevention migraine
body massage oil, facial mask, and ready-to-drink jelly from snake fruit

Conditions: Body Massage Oil From Snake Fruit; Facial Mask From Snake Fruit; Jelly From Snake Fruit

Summary: this study consisted of three sub-studies including 1) development and evaluation of body massage oil from snake fruit on skin moisture, elasticity, oiliness, and melanin in healthy participants 2) development and evaluation of facial mask from snake fruit on skin moisture, elasticity, oiliness, and melanin in healthy participants and 3) development and evaluation of ready-to-drink jelly from snake fruit on controlling blood glucose and endurance time in healthy participants.

study 1: senventy-one male and female participants, aged 23.99 ± 5.68 years were randomly assigned into 3 groups including 1) control group (n = 23): participants received thai massage without any oil for 1 hour/day, 1 day/week for 12 weeks 2) treatment-1 group (n = 23): participants received thai massage with pure coconut oil which is a popular oil used in spa for 1 hour/day, 1 day/week for 12 weeks and 3) treatment-2 group (n = 25): participants received thai massage with oil mixed with snake fruit extract for 1 hour/day, 1 day/week for 12 weeks. study 2: fifty-nine male and female participants, aged 23.39 ± 4.84 years were randomly assigned into 2 groups including 1) control group (n = 29): participants did not receive any facial mask for 12 weeks and 2) treatment group (n = 30): participants received home-based program facial mask with snake fruit extract for 30 min/day, 2 days/week for 12 weeks. study 3: this study was divided into 2 sub-stidies. study 3.1: twenty-five male and female participants, aged 22.60 ± 3.33 years were randomly consumed with either control jelly or jelly with snake fruit juice at 3.5 g/kg body weight. all participants were analyzed for blood glucose level before consumption and after consumption at 30, 60, 90, and 120 min. study 3.2: twenty-three male and female participants, aged 21.57 ± 1.88 years were randomly consumed with either control jelly or jelly with snake fruit juice at 3.5 g/kg body weight. after each consumption, all participants performed leg cycling at intensity 60% of maximal oxygen consumption as long as tolerance (time to exhaustion test).

Eligibility criteria:
inclusion criteria: * man or woman * aged between 18 to 35 years * healthy * interested in body massage with oil or facial mask or jelly from snake fruit exclusion criteria: * history of adverse effects from body massage * skin allergy * skin disorders * skin wounds * history of allergy to coconut or plant oil * history of allergy to facial mask, i.e., mask from fruit * history of allergy to snake fruit or gelatin * signs or symptoms of fever or infection * abnormal body mass index * regular smokers or alcohol drinkers (\>2 times per week) * regular exerciser (\>2 times per week or \>150 min per week) * regular intake of dietary supplements, i.e., vitamins, antioxidants * hypertension, diabetes, cardiovascular disease, respiratory disease, endocrine disease, neuromuscular disease, musculoskeletal disease, liver disease, renal disease, immune disease, infectious disease, or cancer
intra-corporeal vs extra-corporeal anastomosis in laparoscopically assisted right hemicolectomy

Conditions: Pain

Summary: the creation of an intracorporeal anastomosis during right hemicolectomy is regarded as superior than the extracorporeal anastomosis in terms of recovery of peristalsis, aesthetic results, analgesia requirements and length of hospital stay. the objective of this study is to compare the postoperative results of intracorporeal versus extracorporeal anastomosis in patients undergoing laparoscopic right hemicolectomy.

laparoscopic surgery has entailed a great technical revolution in colorectal surgery, providing a better and quicker return to normal functions of the patients, associating a lower morbidity and better aesthetic results compared with traditional open surgery. this study wants to find the difference between intracorporeal and extracorporeal anastomosis. the creation of an intracorporeal anastomosis in right hemicolectomy seems superior to extracorporeal anastomosis in terms of recovery of the normal bowel function, wound size, aesthetic results and analgesia requirements. this will entail a shorter hospital stay. several studies have demonstrated this but all of them are retrospective non randomised. in terms of postoperative pain, the most accepted theory is that it depends on the traction of the porto-mesenteric axis. when the intracorporeal anastomosis is performed there is no traction of this mesenteric axis while in the extracorporeal anastomosis this traction is more important in obese patients. this traction of the mesentery, as well as being one of the main factors related with postoperative pain, is responsible of the postoperative adynamic ileus, that should have a higher incidence when the manipulation is higher. in the patients undergoing an intracorporeal anastomosis, the assistance incision will be a suprapubic pfannenstiel. in the patients undergoing an extracorporeal anastomosis the assistance incision will be a transverse in the right upper quadrant. it is well known that the pfannenstiel incision has a lower incidence of superficial surgical wound infection, a lower rate of incisional hernia, a lower need of analgesics, and better aesthetic results, when compared with the incision in the right upper quadrant. all this factors should entail a lower hospital stay in patients undergoing an intracorporeal anastomosis.

Eligibility criteria:
inclusion criteria: * surgical procedure with curative purpose. * american society of anaesthesiologists physical status (asa) i, ii and iii. * elective surgery. * informed consent. exclusion criteria: * denial of informed consent. * advanced neoplasia. * urgent surgery. * asa iv.

Keywords: intracorporeal anastomosis laparoscopic colectomy outcomes length of stay analgesia aesthetic extracorporeal anastomosis laparoscopic
turkish version of revised neurophysiology of pain questionnaire

Conditions: Chronic Low-back Pain; Neck Pain

Summary: the neurophysiology of pain questionnaire was first developed in english to test whether healthcare staff and patients could exactly understand pain neurophysiology. this questionnaire which contains 19 items was developed from the exam questions of students interested in post-graduate pain medicine. catley et al. (2013) investigated the psychometric properties of the modified neurophysiology of pain questionnaire with a few word differences from the original version by conducting a rash analysis on 300 patients with chronic spinal pain. acceptable internal consistency and test-retest reliability of the questionnaire were recorded. however, it was stated that 7 items negatively affect psychometric properties of the questionnaire. as a result, the author concluded that the questionnaire had sufficient psychometric properties for use in chronic spinal pain subjects, but further studies were needed. the neurophysiology of pain questionnaire was used to measure a knowledge about pain in different studies. the validity and reliability studies of the dutch, french and brazlian portuguese versions of the neurophysiology of pain questionnaire were conducted in the literature. the aim of our study was to translate the revised neurophysiology of pain questionnaire into turkish language and to investigate its psychometric properties.


Eligibility criteria:
inclusion criteria: * patients with spinal pain lasting more than three months * patients who older than 18 years of age * patients who can understand and read turkish. exclusion criteria: * patients with specific spinal pain such as trauma, fracture, infection, inflammatory disease and tumor * patients who have undergone spinal surgery in the last 3 months * patients who have received pain neurophysiology education in the last year.

Keywords: neurophysiology pain questionnaire reliability validity pain low back pain
pain and abdominal breathing exercises

Conditions: Analgesia; Breathing

Summary: postoperative evaluation of patients who did and did not do preoperative abdominal breathing exercises.

the respiratory type and pattern of all patients will be recorded before gallbladder surgery. in group p, abdominal breathing training will be given to the patients in this group. they will perform abdominal breathing for at least 5 minutes 6 times a day until surgery. in group c,patients who are not given abdominal breathing. in the intraoperative period, 10 mg / kg paracetamol and 0.05 mg / kg morphine will be used for postoperative analgesia. after surgery, all patients will be given 10 mg/kg paracetamol every 8 hours and will be fitted with a patient-controlled analgesia (pca) device (tramadol hcl). pca device bolus dose will be set to 20 mg, lock time will be set to 10 minutes and the number of buttons per hour will be set as 3.for postoperative analgesia.after surgery, nrs scores of the patients will be evaluated (in the recovery room, 1,2,6,12 and 24 hours. preoperative anxiety, postoperative discharge time and analgesic consumption of all patients will be recorded.

Eligibility criteria:
inclusion criteria: * planned to gall bladder surgery * an american society of anesthesiologists score of 1,2 or 3 exclusion criteria: * severe cardiovascular disease * respiratory disease * psychiatric disease * those who have chronic pain