Kornimate/medical-research-clean huggingface dataset:
implant-supported fixed dental prostheses (fdps) with cantilever extension

Conditions: Dental Implant Failed; Prosthesis Failure; Peri-Implantitis

Summary: to report the clinical and radiographic outcomes of implant-supported fixed dental prostheses with full-ceramic cantilever extensions (fdpcs) after a function time ≥ 12 months.

patients with full ceramic fdpcs in anterior and posterior areas will be clinically and radiographically re-evaluated. mesial and distal radiographic marginal bone levels (mbls) from baseline (i.e. delivery of fdpc) to the follow-up examination were calculated and compared between implant surfaces adjacent to and distant from the cantilever extension. implant survival rate (%), pocket probing depth (ppd), presence/ absence of bleeding on probing (bop) and presence/absence of mechanical/technical and biological complications were recorded.

Eligibility criteria:
inclusion criteria: * patients aged ≥18 years * written informed consent * patients with systemic health or controlled medical conditions * patients with healthy or treated periodontal conditions * patients enrolled in regular supportive periodontal therapy (spt) * patients without clinical signs of bruxism and/or oral parafunctions * 2 osseointegrated dental implants in the canine or posterior areas of maxilla and mandible following transmucosal placement and healing of 3-6 months * tissue level solid-screw implants with a sand-blasted and acid- etched (sla) surface with an endosseous diameter of 3.3, 4.1 or 4.8 mm, a length of 8, 10 or 12 mm, a shoulder diameter of 4.8 mm and a supracrestal machined neck with a height of 1.8 or 2.8 mm (straumann® dental implant system, institut straumann ag, basel, switzerland) * full-ceramic * utilization of prefabricated titanium abutments * cemented (3m™ espe ketac™ cem, seefeld, germany) or screw-retained fixed dental prostheses with a mesial or distal cantilever extension (fdpcs) * cantilever extension corresponding to 1 premolar unit (i.e., 6-7 mm) * absence of occlusal contacts or guidance on the cantilever extension at baseline * opposing dentition consisting of natural teeth or fixed or removable prosthetic restorations * availability of a periapical radiograph at baseline (i.e. fdpc delivery) * availability of ppd measurements (mm) taken at baseline at 4 sites/implant with a graduated michigan periodontal probe (deppeler sa, rolle, switzerland) * availability of bop measurements (%) (lang et al., 1986) taken at baseline at 4 sites/implant with a graduated michigan periodontal probe (deppeler sa, rolle, switzerland). exclusion criteria: * untreated or active periodontal diseases * immediate implant placement (i.e., type i implant placement according to hämmerle et al., 2004) * fdpcs in the aesthetic zone (i.e., replacement of maxillary or mandibular incisors) * fdpcs supported by hollow-screw and hollow-cylinder implants
metabolomics fingerprinting and metabolic dynamics after hiv infection

Conditions: HIV

Summary: the purpose of this plot study is to find out the relationship between metabolic changes and anti-retroviral therapy (art), life style and clinical conditions of hiv-infected patients using nuclear magnetic resonance (nmr) based systems biology approach and metabolomics methodology.

since the clinical application of anti-retroviral therapy (art) in 1997, the life expectancy of hiv infected patients has been prolonged greatly. however,side effects of art including metabolic abnormalities have become the main factors influencing patients' quality of life. among which the abnormal lipid metabolism plays an important role. meanwhile, metabolic conditions differ from patients applying to different combinations of art drugs,life style and clinical conditions. metabolomics can measure the dynamic metabolic responses of the body to stimuli or modifications. using nuclear magnetic resonance (nmr) as tools can systematically analyse the process of lipid metabolism. metabolomics fingerprinting can be defined as the complete complement of small molecule (\< 1500 da) metabolites found in a specific cell, body fluid, organ or organism. therefore, the study of the impact of metabolic changes and anti-retroviral therapy (art), life style and clinical conditions is of importance in enhancing the adherence and improving the clinical outcomes of hiv infected patients.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of hiv infection exclusion criteria: * pregnancy * individual who is participating in other trial(s)

Keywords: hiv metabolomics fingerprinting
serum concentrations, physical and psychological well-being in metabolic syndrome

Conditions: Metabolic Syndrome

Summary: the purpose of this study was to investigate the serum concentrations, physical and psychological well-being characteristics in patients having chronic musculoskeletal pain with metabolic syndrome, and to compare patients without metabolic syndrome.

metabolic syndrome (mets) is a combination of metabolic risk factors such as impaired glucose level, dyslipidemia, hypertension, and central obesity. mets has become a large public health issue with common interrelation to different accompanying disorders. moreover, the link between mets and musculoskeletal disorders has previously been demonstrated. presence and prevalence of mets in patients having musculoskeletal pain seems common and interrelated.however, to our knowledge, manifestations with clinical symptoms of mets, some inflammatory markers via serum concentrations and physical and psychological health profiles of patients with seeking treatment from outpatient physical therapy for musculoskeletal pain conditions have not been researched up to now.

Eligibility criteria:
inclusion criteria: to be a volunteer patient with a chronic non-specific musculoskeletal pain disorder, including knee osteoarthritis, rotator cuff tear, adhesive capsulitis, and non-specific low back, back or neck pain for more than 6 months. exclusion criteria: the presence of severe physical disability, psychiatric disorder, malignant tumors, pregnancy, chronic alcohol consumption, gout, heart failure, liver and renal dysfunction.

Keywords: physical activity pain uric acid
the effect of yoga on sleep quality, fatigue and physical activity level of multiple sclerosis

Conditions: Multiple Sclerosis

Summary: this randomized controlled study will be conducted to examine the effects of yoga on sleep, fatigue and physical activity in individuals diagnosed with relapsing-remitting multiple sclerosis.


Eligibility criteria:
inclusion criteria: patients diagnosed with relapsing-remitting multiple sclerosis being an adult between the ages of 18-65 exclusion criteria: * those who have communication problems those with psychiatric problems having a condition that prevents you from doing yoga

Keywords: fatigue sleep quality yoga
a phase iii study of abatacept (bms-188667) in patients with active rheumatoid arthritis and inadequate response to methotrexate

Conditions: Rheumatoid Arthritis

Summary: short term: the purpose of this clinical research study is to learn if abatacept (bms-188667) in combination with methotrexate is better than methotrexate alone in participants that have active rheumatoid arthritis and are not responding to methotrexate. the safety of this treatment will also be studied. long term extension: the purpose of this amendment is to provide participants who have completed the initial 12-month double-blind treatment period the opportunity to receive open label treatment with active drug treatment until abatacept is approved in the local country or until clinical development has been discontinued.


Eligibility criteria:
* rheumatoid arthritis (ra) for greater than 1 year from the time of initial diagnosis of ra. * participants must have been taking methotrexate for at least 3 months with at least a weekly dose of 15 mg.
microbiological keratitis in a countryside city of brazil

Conditions: Keratitis

Summary: the purpose of this study is to identify the predisposing factors, epidemiological features and clinical and microbiological diagnosis of infectious keratitis in two public referral centers of ophthalmology in a countryside city of brazil.


Eligibility criteria:
inclusion criteria: * all patients admitted with clinical suspicious of keratitis from june 2008 to june 2009 (keratitis group) * 37 volunteers without any ophthalmologic claim, recruited in the two ophthalmology centers listed (control study group) exclusion criteria: * in the control study group, no infectious ocular disease was accepted

Keywords: keratitis
hybrid rehabilitation approach through group exercise and telerehabilitation in patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the aim of the study is to determine the benefits of outpatient group rehabilitation with subsequent telerehabilitation. the patient will participate in a 12-week circuit training, including training once a week in a group of six under the guidance of two physiotherapists. after the outpatient rehabilitation, the patient will gain access to a mobile application and will be asked to record all physical activities there.

in the czech population more than 20,000 people have been diagnosed with multiple sclerosis (ms), an autoimmune disease affecting a patient's central nervous system. this disease has a wide range of symptoms, with the most common ones being various motor disorders that negatively affect the locomotor function and patients' quality of life. the positive effect of physical activity on human health is well known. this study aims to examine the effect of hybrid exercise program on people with ms. this exercise program includes ambulatory circuit training for twelve weeks followed by telerehabilitation. the aim of the study is to find out whether the exercise program will positively affect the movement skills of probands and improve their quality of life. testing will done before the start of the exercise program, after twelve weeks and after 6 months. movement skills will be tested by a set of movement tests called minibest test. for measuring quality of life the investigators will the sf-36 questionnaire will be used. another goal will analyze participants' satisfaction with the intervention and adherence to regular physical activity. the investigators anticipate that regular physical training combined with telerehabilitation will increase the motivation and effectiveness of independent training in people with ms leading to improvment of physical fitness, physical activity levels and quality of life.

Eligibility criteria:
inclusion criteria: * age ≥ 18 * confirmed diagnosis of multiple sclerosis based on mcdonald criteria * minimal one month from last relapse * possibility to use smartphone or tablet because of using rehabilitation application exclusion criteria: * illnesses which can limiting exercises activities (e.g. orthopedic, cardiology or other neurological diseases) * cognitive deficit which can limiting cooperation (fill a questionnaire, comply with movement task, using application) * relapse of diseases during study

Keywords: multiple sclerosis telerehabilitation circuit training movement skills quality of life
examination of the large intestine with camera capsule in patients with blood stream infection with gut-associated bacteria

Conditions: Colorectal Cancer (CRC); Colorectal Cancer and Pre-cancer Polyps; Blood Stream Infection; Anaerobic Infection; Bacteriaemia

Summary: the goal of this observational study is to diagnose colorectal cancer or precancerous tumors in participants over the age of 18 hospitalized with blood stream infection with anaerobic gut-associated bacteria. the main question it aims to answer is: • how prevalent is cancer and precancerous tumors in the large intestines and rectum in patients with anaerobic bacteremia? participants will be offered an examination using colon capsule endoscopy 4-8 weeks after discharge.


Eligibility criteria:
inclusion criteria: * older than 18 years * blood culture with growth of one or more of the following bacterial genera bacteroides, clostridium, filifactor, fusobacterium, gemella, granulicatella, parvimonas, peptostreptococcus, prevotella, solobacterium, peptoniphilus, ruminococcus, finegoldia and streptococcus. * able to provide oral and written informed consent * able to read and speak danish exclusion criteria: * prior colorectal cancer diagnosis * history of stenosis of the gastrointestinal tract * previous treatment of inflammatory bowel disease * previous major surgery of the gastrointesinal tract (e.g. gastric bypass) * colostomy * pacemaker/icd * pregnancy or breastfeeding * allergies to the bowel preparation regimen * severe kidney disease * focus of infection in skin and soft tissue or outside the truncus (e.g. decubitus, diabetic foot ulcer) * tumor in the colon or rectum at diagnostic imaging * discharge before result of blood culture * transfer to other hospital outside the region

Keywords: colorectal cancer anaerobic bacteria bacteria, anaerobic cancer, colorectal bacteremia blood stream infection colon capsule endoscopy
iv pca with or without continuous dose vs oral opioid to maintain analgesia for severe cancer pain after successful titration

Conditions: Cancer Pain

Summary: based on the previous hmorct09-2, the results show that iv pca for analgesia maintenance improvements control of severe cancer pain after successful titration. therefore, a study is planned to further explore the difference of efficacy and safety between pca with continuous + bolus dose versus bolus-only.


Eligibility criteria:
inclusion criteria 1. age 18 to 80 years; 2. histologically or cytologically confirmed malignant solid tumor; 3. persistent severe cancer-related pain (≥7 at rest on the 11-point numeric rating scale \[nrs\], where 0=no pain and 10=excruciating pain) in the 24 hours before screening; 4. no radiotherapy to the painful area prior to randomization; 5. no radiotherapy, chemotherapy, hormone therapy, targeted therapy, or bisphosphonate therapy within 7 days before randomization; 6. successful ipca-hm titration within the past 24 hours; 7. no history of psychiatric disorders; 8. ability to complete questionnaires; 9. ability to correctly understand and follow medication guidance from doctors and nurses; 10. ecog performance status ≤ 3; 11. provided written informed consent. exclusion criteria 1) patients with non-cancer-related pain; 2) patients with paralytic ileus; 3) patients with brain metastases; 4) patients with hypersensitivity to morphine or hydromorphone; 5) abnormal laboratory results: creatinine ≥ 2-fold of upper limit of normal (uln) value, alanine aminotransferase (alt) or aspartate aminotransferase (ast) ≥ 2.5-fold of the uln value (≥ 5-fold for subjects with liver metastasis or primary liver cancer), or child-pugh class c liver function; 6) patients unable to take oral medication; 7) patients with uncontrolled nausea or vomiting; 8) prior use of hydromorphone, morphine, or pca devices within 14 days before screening; 9) use of monoamine oxidase inhibitor drugs (maoid) within the two weeks before randomization; 10) women who are pregnant, lactating, or planning to be pregnant within one month after the trial completion; 11) patients who abuse alcohol; 12) patients with any other medical condition or reason, in the investigator's judgment, that would make them unsuitable to participate in the clinical trial.

Keywords: orally iv pca with continuous + bolus dose iv pca with bolus-only dose
bacteriostatic normal saline versus lidocaine for intradermal anesthesia

Conditions: Chronic Pain

Summary: the purpose of this study is to determine if creation of a skin wheel with bacteriostatic normal saline, which includes 0.9% benzyl alcohol, is less painful and provides a similar level of anesthesia compared to 1% lidocaine. participants will receive both types of anesthesia, in random order.

most chronic pain procedures or injections utilize medications (e.g. local anesthetics) to numb the skin in an effort to reduce procedure-related pain; however, they can also be a significant cause of pain leading the patient to abort the procedure. studies have looked at alternative medications and techniques that lessen the pain but still provide similar levels of anesthesia ("numbing"). one such alternative medication is normal saline that includes benzyl alcohol. studies researching this specific medication have usually examined procedural pain related to drawing blood or placing an intravenous (iv) catheter but not for chronic pain related procedures. this is a single site randomized double-blinded clinical trial that will compare the standard of care (1% lidocaine) with bacteriostatic normal saline (saline with benzyl alcohol) administered as a skin wheal during a diagnostic procedure in patients with chronic low back pain. the order of administration of the medication will be randomized and the medication will be blinded to both the subject and the investigator performing the procedure. skin wheals will be created with each medication, and the subject's level of pain will be assessed after each one to measure how painful the creation of the skin wheal was. then, a spinal needle for the diagnostic procedure will be placed through the skin wheal and the subject's level of pain will be assessed after each one to measure the level of anesthesia (or numbing) that each one provides. the objectives of this study are to determine if administration of bacteriostatic normal saline causes less discomfort than 1% lidocaine and provides a similar level of anesthesia/numbing for the procedure. the study will take place at the grady pain clinic and participants will be identified from patients that are scheduled to undergo a specific low back procedure - diagnostic lumbar medial branch block. this research study will help identify potential alternatives to the standard of care for numbing of skin during chronic pain procedures that may reduce procedure-related pain and discomfort thus making the procedure more tolerable.

Eligibility criteria:
inclusion criteria: * patients scheduled for an initial lumbar medial branch block exclusion criteria: * allergy to local anesthetics * fibromyalgia * inability to provide informed consent in english * adults unable to consent * individuals who are not yet adults (infants, children, teenagers) * pregnant women * prisoners

Keywords: local anesthetic
vr intervention to improve police safety

Conditions: Autism Spectrum Disorder; Autism

Summary: the primary objective of this study is to demonstrate the efficacy of floreo's police safety module (psm) in adolescents and adults with autism spectrum disorder (asd) by assessing improvement in police interaction skills as compared to a video modeling intervention.

advances in virtual reality (vr) technology offer new opportunities to design interventions targeting the core deficits associated with autism spectrum disorder (asd) and promote acquisition of skills necessary for effective navigation of challenging social situations, such as engagement with law enforcement. researchers have explored the potential of virtual reality technology in targeting autism-related deficits, but at this time there are no evidence-based vr interventions for asd. while most research labelled vr for the purposes of therapy has not been immersive, in recent years, the commercial introduction of head-mounted displays (hmd) and lower cost of virtual reality technology have led to greater interest in therapeutic applications of vr. as part of a mission to develop vr products for individuals with asd, investigators will collaborate with a commercial tech start-up company, floreo technology, to study a mobile vr module for police safety skills. investigators seek to evaluate the safety and feasibility of the mobile vr police safety module (psm) and the effectiveness of the module in improving police interaction skills in adolescents and adults with asd.

Eligibility criteria:
inclusion criteria: * males or females age 12 to 60 years. * documented autism spectrum disorder (asd) diagnosis * verbal intelligence quotient (iq) \>/= 75 (verbal and non-verbal) * informed consent (if adult) or parental/guardian permission (if child or adult with diminished capacity) and, if applicable, assent exclusion criteria: * participation in pilot virtual reality (vr) study at the children's hospital of philadelphia (chop) * personal or family history of seizures or a seizure disorder * primary sensory impairment (e.g., blindness, deafness) * personal or family history of migraines * history of vertigo * history of strabismus, other eye muscle problems, or eye surgery * history of concussion with hospitalization * diagnosis of a known genetic syndrome (e.g., down syndrome, fragile x syndrome) * history of a medical condition which has affected/affects cognitive, sensory, or motor functioning (e.g., fetal alcohol syndrome, brain injury, stroke, brain tumor) * non-english speaking * parents/guardians or subjects who, in the opinion of the investigator, may be non-compliant with study schedules or procedures

Keywords: intervention technology
rotational atherectomy, lithotripsy or laser for the treatment of calcified stenosis

Conditions: Coronary Artery Disease

Summary: some data exist about the efficacy and safety of rotational atherectomy, intravascular lithotripsy and excimer laser to modify calcified plaques. however there is no direct randomized comparison between these three tools in this scenario. the aim of this pilot randomized trial is to compare the safety and efficacy of these three techniques during pci of moderate to severe calcified lesions.

some data exist about the efficacy and safety of rotational atherectomy, intravascular lithotripsy and excimer laser to modify calcified plaques. however there is no direct randomized comparison between these three tools in this scenario. the aim of this pilot randomized trial is to compare the safety and efficacy of these three techniques during pci of moderate to severe calcified lesions. the primary endpoint will be the percentage of stent expansion measured with optical coherence tomography. between secondary endpoints we will analyze the strategy success (defined as successful stent delivery and expansion with \<20% residual stenosis and timi 3 flow without crossover or stent failure) and presentation of clinical adverse at 1 year follow-up .

Eligibility criteria:
inclusion criteria: * patients \>18 years. * stenosis ≥70% in a coronary artery with a diameter ≥2,5 y ≤4 mm. * moderate to severe angiographic calcification * stable coronary artery disease or nstemi. * native coronary vessel or bypass graft. exclusion criteria: * knwon allergies to aspirin or p2y12 inhibitors. * stemi. * cardiogenic shock at the time of pci. * treated lesion in a bifurcation with side branch diameter \> 2mm. * absence of informed consent. * impossibility for 1year follow up.