Kornimate/medical-research-clean huggingface dataset:
effect of ferrlecit® versus oral iron on iron deficient chronic kidney disease (ckd) patients

Conditions: Anemia, Iron-Deficiency; Kidney Failure, Chronic

Summary: this study compares the effect of ferrlecit® (a form of intravenous iron) to ferrous sulfate (a form of oral iron) in treating anemia and iron deficiency in chronic kidney disease patients who are not receiving erythropoietic agents (hormones that stimulate the bone marrow to make more red blood cells).


Eligibility criteria:
inclusion criteria: * moderate to severe anemia * iron deficiency * moderate to severe chronic kidney disease exclusion criteria: * receiving dialysis * known sensitivity to ferrlecit® or any of its components * receiving therapy with erythropoietic agent * clinically unstable

Keywords: iron deficiency anemia chronic kidney disease sodium ferric gluconate anemia, iron-deficiency/drug therapy/etiology kidney failure, chronic/blood/complications/therapy
algorithm-based management to reduce the recurrence of gi bleeding and severe epistaxis in von willebrand disease

Conditions: Von Willebrand Disease (VWD)

Summary: will manage is a prospective multicenter controlled open label randomized trial comparing an algorithm-based multidisciplinary management to a standard of care to reduce the incidence of bleeding (gi bleeding or severe epistaxis) recurrence in von willebrand disease.


Eligibility criteria:
inclusion criteria: * males and females adults aged \> 18 years * with a constitutional von willebrand disease (according to the phenotypic criteria of the french reference center of von willebrand disease) * with a gi bleeding \[either overt (any hematemesis, any melena or hematochezia with at least a 2g/dl drop in hemoglobin) or occult (iron deficiency anemia with at least 2g/dl drop in hemoglobin)\] with the presence of angiodysplasia or a negative finding on digestive conventional endoscopy or with a severe epistaxis (requiring red blood cells transfusion or treatment with vwf concentrates) * be affiliated to a social security scheme * written informed consent obtained exclusion criteria: * acquired von willebrand disease * presence of an inhibitor to vwf or a contra indication to vwf concentrates * contra-indication to videocapsule endoscopy * refusal of the procedures part of the study * pregnant women or breastfeeding * short-life expectancy * liver cirrhosis child-pugh c or diagnosed portal hypertension * cancer currently undergoing chemotherapy * inability to provide informed consent * patient under justice protection

Keywords: von willebrand disease gastrointestinal bleeding angiodysplasia epistaxis
a safety study of arry-403 in patients with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: this is a phase 1 study, involving a 1-day dosing period, designed to test the safety of investigational study drug arry-403 in patients with type 2 diabetes. approximately 36 patients from the us will be enrolled in this study.


Eligibility criteria:
key inclusion criteria: * male or female with willingness and ability to use protocol-specified methods of contraception, except females of nonchildbearing potential. * diagnosis of type 2 diabetes less than 5 years prior to study start. * hba1c ≥ 6.5% and ≤ 10%. * bmi ≥ 25 and ≤ 40.0 kg/m2. * additional criteria exist. key exclusion criteria: * recent history (i.e., less than 6 months) or concomitant/ongoing clinically significant hematologic, renal, pulmonary, gastrointestinal, hepatic, psychiatric, neurologic, dermatologic, or allergic disease (including drug allergies that are clinically significant and not remote, but excluding untreated, asymptomatic, seasonal allergies at the time of dosing). * significant cardiac disease, myocardial infarction within 6 months of study start, unstable angina, congestive heart failure, known arrhythmias of ventricular etiology, unexplained syncope or syncope/seizures related to arrhythmia. * history of gastric surgery, vagotomy, bowel resection, or any surgical procedure that might interfere with gastrointestinal motility, ph, or absorption. * active infectious diseases including hepatitis b, hepatitis c, or human immunodeficiency virus (hiv). past history and inactive hepatitis b and c, as confirmed by serological testing, are allowed. * a positive test for drugs or alcohol. * women who are pregnant or breastfeeding. * donation or loss of ≥ 550 ml of blood (including plasmapheresis) or receipt of a transfusion of any blood product within 8 weeks prior to first dose of study drug. * additional criteria exist.
assessment and treatment patients with atypical facial pain trough repetitive transcranial magnetic stimulation

Conditions: Atypical Facial Pain or Atypical Odontalgia

Summary: atypical facial pain is a chronic condition and presents controversies during diagnostic and treatment, between specialist not have consensus about the pathophysiology. it is possible consider this entitie a potential neuropathic cause without pathological signs. it knows the repetitive transcranial magnetic presents good results in the treatment of chronic pain coditions. the aim this study is evaluated the thresholds and excitability cortical in patients with afp and verify the patterns of improvement in pain for patients undergoing rtms compared to controls, as well as the therapeutic response to neuromodulation procedures. this enroll 20 patients with daf and 20 controls treated with rtms (5 sessions) and evaluated through questionnaires (edof clinical record, mcgill pain questionnaire, visual analogue scale, inventory of symptoms of neuropathic pain, neuropathic pain dn4 questionnaire, sf -36, brief pain inventory). at the end of the data will be statistically analyzed and expressed as mean and standard deviation, and analyzed by student's t test, analysis of variance (anova), tukey-kramer and pearson correlation. the level of significance is 5%. the results will be published in journals indexed in the area both nationally and internationally and presented at conferences and scientific meetings.


Eligibility criteria:
inclusion criteria: * fulfill criteria of atypical facial pain by international headache society * signed term of informed consent exclusion criteria: * trauma of skull, epilepsy don't treated, * use of medications decrease the seizure threshold * patients in use of drugs, how cocaine and alcohol * neurosurgical clips, pacemakers, increased intracranial pressure (risk of sequelae after seizure) * pregnant or lacting women

Keywords: atypical facial pain atypical odontalgia repetitive transcranial magnetic stimulation neuropathic pain chronic pain assessment
impact of electromagnetic field therapy on pain and function in patients with mechanical back pain

Conditions: Mechanical Low Back Pain

Summary: this study aims to investigate the impact of electromagnetic field therapy on pain severity and functional disability in mechanical back pain patients suffering from myofascial trigger points.

lower back pain, or lbp, is a major global health issue that affects functioning, social participation, and personal financial prosperity on a variety of biophysical, psychological, and social levels. in today's industrial society, it impacts roughly 50-80% of people who are of working age. mechanical back pain patients suffer from myofascial trigger points (mtrps), which are classified as either active or latent. activated mtrps cause either sudden onset of pain or in response to movement, stretching, or compression. latent mtrps are typically symptom-free, but when squeezed, they can re-create pain or irritation. muscle weakness and limited rom are other common signs of mechanical back pain, along with local as well as referred pain that affect patients functional activities. recently, there has been a focus on non-pharmacotherapy for low back pain. one of them is electromagnetic field therapy (pemf) which uses electromagnetic field pulses to stimulate tissue healing without causing heat damage to the tissue. the fda has given electromagnetic field therapy devices approval for treating post-operative pain, swelling, and osteoarthritis. furthermore, pemf devices are frequently used to treat bone fractures, inflammation, arthritis, pain, swelling, and chronic wounds. thus, the purpose of this study is to ascertain how electromagnetic field therapy affects the degree of pain and functional impairment in mechanical back pain patients suffering from myofascial trigger points.

Eligibility criteria:
inclusion criteria: 1. the patients age from 20 to 40 years for both genders. 2. patients (office worker) with mechanical back pain for 3 months ago and has not been diagnose as a specific disease or spinal abnormality. 3. patients suffering from active mtrps in lower back muscles. 4. the study patients must be willing to participate in the study. exclusion criteria: 1. neurological, systemic illness and infectious diseases such as rheumatologic diseases, tumor. 2. psychiatric/mental deficit. 3. patients who had a previous surgical history (within 6 months) were also excluded prior to the baseline assessment. 4. vertebral compression fracture 5. pregnancy and lactation. 6. existing lower limb symptoms. 7. cardiopulmonary disorders with reduced activity tolerance. -

Keywords: electromagnetic field mechanical back pain myofascial trigger point pain severity
percutaneous catheter decompression in the treatment of elevated intra-abdominal pressure

Conditions: Compartment Syndromes

Summary: intra-abdominal hypertension (iah) and abdominal compartment syndrome (acs) have traditionally been treated surgically through emergent laparotomy. intensivist-performed bedside drainage of free intra-peritoneal fluid or blood \[percutaneous catheter decompression (pcd)\] has been suggested as a less-invasive alternative to traditional open abdominal decompression (oad). this study assesses the relative efficacy of pcd vs. oad in reducing elevated intra-abdominal pressure (iap).

intra-abdominal hypertension (iah), the presence of elevated intra-abdominal pressure (iap), and abdominal compartment syndrome (acs), the development of iah-induced organ-dysfunction and failure, are both associated with significant morbidity and mortality when appropriate and expedient treatment is not rendered. elevated iap is an independent predictor of mortality during critical illness and serial iap measurements are increasingly being performed in the intensive care unit (icu) setting. despite growing evidence demonstrating the survival benefit of serial iap monitoring and abdominal decompression in patients with iah / acs, some physicians are reluctant to consider decompression or unable to convince a surgeon to open the abdomen of patients manifesting iah-related organ failure. percutaneous catheter drainage (pcd) of free intra-abdominal fluid, air, abscess, or blood has been suggested in several case reports and small clinical trials to be a less invasive technique for reducing iap and potentially correcting iah-induced organ dysfunction. pcd, performed under ultrasound or computed tomography guidance, is described in the current world society of the abdominal compartment syndrome (wsacs) consensus recommendations as a therapeutic option, but insufficient data currently exist to support a strong evidence-based recommendation for the percutaneous treatment of iah / acs (10,12). since 2007, we have employed pcd in the treatment of patients with iah due to free intraperitoneal fluid and blood. this study describes our experience with the less invasive pcd technique compared to contemporaneous matched control patients who received traditional open abdominal decompression (oad) for the treatment of iah / acs.

Eligibility criteria:
inclusion criteria: * elevated intra-abdominal pressure exclusion criteria: -

Keywords: intra-abdominal pressure intra-abdominal hypertension abdominal compartment syndrome open abdomen percutaneous
pain discomfort enjoyment levels during moderate exercise

Conditions: Overweight and Obesity

Summary: in order to better understand how pre-existing pain and also discomfort/enjoyment during exercise may influence physical activity and be related to body weight the investigators are seeking to examine these as they relate to overweight/obesity compared to normal weight individuals. ultimately, the investigators think that people with obesity may have more and be more sensitive to pain and have lower discomfort tolerance that may lead them to experience exercise more negatively. in the real world, this could result in them stopping exercise sooner or avoiding exercise all together. therefore it is important for the investigators to begin to understand this issue better. in addition, some preliminary studies in animals suggest that the quality of the diet may influence pain sensitivity. this has yet to be examined in humans. as such the investigators will examine whether self-reported diet quality and also some markers in participants' blood that can tell the investigators about the recent quality of a person's diet, are related to the measures of pain, enjoyment and discomfort during exercise.


Eligibility criteria:
inclusion criteria: * age: 18-60 years. * bmi ≥ 18.5 kg/m2. * typically exercise (moderate-intensity aerobic exercise - e.g. brisk walking) less than 150 minutes per week (last 3 months) * no known contraindications for participating in up to 42 minutes of moderate intensity physical activity. * have not been told by a qualified healthcare provider to avoid moderate physical activity. exclusion criteria: * unable/unwilling to provide informed consent. * having motor impairment. * currently diagnosed with diabetes mellitus, experiencing uncontrolled hypertension (i.e. systolic blood pressure (sbp) \> 140 mmhg or diastolic blood pressure (dbp) \> 90 mmhg), having a history of ischemic heart disease, cerebrovascular accidents, neurological disease or current/past severe psychiatric illness (e.g. severe depression, psychosis, schizophrenia) that required hospitalization, severe current untreated depression (i.e. score in the severe depression range on the hospital anxiety and depression scale; hads), current suicidal ideation, and current or past suicide attempts. * women who are pregnant or nursing. * diagnosed history of eating disorders such as bulimia nervosa, anorexia nervosa. * diagnosed history of substance abuse or alcohol abuse. * currently undergoing pain management treatment (pharmacologic and or behavioral). * currently taking anti-depressant medicines * have been instructed by a qualified healthcare provider to refrain from moderate physical activity at any time during the last 12 months (reasons other than minor orthopedic injury etc.). * any implanted medical devices (e.g. pacemaker). * currently smoking (within last 12 months).
auditory brainstem response as a diagnostic tool in schizophrenia and bipolar disorder

Conditions: Bipolar Disorder; Schizophrenia; Attention Deficit Disorder With Hyperactivity

Summary: the purpose of this study is to study the predictive value of sensodetect-bera as a diagnostic tool in clinical practice for schizophrenia and bipolar disorder.

background: within the daily clinical work of all medical specialties, objective diagnostic tools are paramount. however, in the psychiatric field such measures are lacking. since 1983 the method of psychoacoustics has been under development in hope to serve this purpose. a recent development of auditory brainstem response (abr/sd-bera), has been proposed as a potential diagnostic tool within psychiatry. the abr is a diagnostic tool used primarily to diagnose sensorineural hearing loss. it detects evoked potentials, generated by neuronal activity in the auditory pathways in the brainstem, within the first 10 ms following acoustic stimulation. the potentials are recorded by surface electrodes placed on the forehead and on the mastoid processes. the wave pattern recorded consists of seven peaks, which are interpreted with respect to latencies and amplitudes. previous studies have aimed to associate the peaks with specific anatomical structures. the method sd-bera is a further development of the standard abr. it uses a wider array of acoustic stimuli, including complex sounds, for instance masking noises. the measuring procedure will roughly take 25 minutes. previous studies using these complex sounds to compare mentally healthy subjects with patients suffering from schizophrenia, adhd and bipolar disorder have shown that the different psychiatric groups exhibit specific wave patterns. aims the aim of the first study is to validate previous results and identify five (n=5) patients with diagnosed adhd, schizophrenia and bipolar disorder, and to compare these patients (n=15) with healthy, age-matched controls. the aim of the second study is to present a blinded study where 12 patients with schizophrenia and 12 patients with bipolar disorder (total n=24) are compared to each other and to healthy controls (n=12) in order to evaluate the method as a diagnostic tool in clinical healthcare practice.

Eligibility criteria:
inclusion criteria: * best-practise diagnosed schizophrenia, bipolar disorder or adhd * diagnosed since at least one year prior to enrollment. exclusion criteria: * serious hearing loss * severe ongoing alcohol abuse or drug abuse * diagnosed psychiatric comorbidity * brain injury following cranial trauma

Keywords: auditory brainstem response abr sd-bera
the effect of cupping on spasticity and function of the lower extremity during rehabilitation after stroke

Conditions: Stroke Gait Rehabilitation

Summary: physical therapists use dry static cupping for the treatment of many conditions, including spasticity for patients post-stroke. while research better describes the effects of dry static cupping for patients with orthopedic conditions, information is lacking on central conditions, such as stroke and resulting spasticity.

cupping is an ancient alternative medicine. a common form of cupping, called dry static cupping, involves creating negative pressure inside a therapeutic cup. the cup is then placed on the skin, creating a light suction effect. in eastern medicine, cupping has been used to treat a variety of diseases. more recently, in western society, cupping has been used after injury, and among other effects, has been found to improve blood volume and tissue oxygenation to an area. these effects have originally been thought to be peripheral in nature, occurring at the cupping site, hence, why cupping has been used for treatment for conditions like carpal tunnel syndrome, spinal pain, knee osteoarthritis, and other musculoskeletal conditions. however, a recent systematic review found cupping to be beneficial for rehabilitation after stroke. these conclusions raise the question of a possible mechanism for cupping to improve impairments related to the central nervous system, such as spasticity after stroke. however, many of the studies to date have serious methodological flaws that limit the direct causation of cupping to the reduction of spasticity. as well, the majority of studies only involve the upper extremity. no study has yet looked at the therapeutic effects of dry static cupping on lower extremity spasticity reduction after stroke.

Eligibility criteria:
inclusion criteria: * age 30-80 * acute stroke (within 6 months of stroke), with spasticity \& hemiparesis of le * referred by doctor for rehabilitation for a stroke-related condition * attending ascension rehabilitation of joliet for rehabilitation * able to read or verbally understand english or spanish exclusion criteria: * absent sensation of the areas to be cupped * significant cognitive impairment * pregnancy * prescription anticoagulant medications * blood clotting disorder * uncontrolled hypertension * uncontrolled diabetes * open wounds within the cupping area * current dvt * hematoma over the cupping area * fracture over the cupping area * active cancer within the cupping area * current use of baclofen * current use of botox * current use of an anti-spasticity medication

Keywords: cupping spasticity stroke rehabilitation
comparison of stability and outcomes in single-radius femoral component for total knee arthroplasty

Conditions: Osteoarthritis

Summary: this is a comparison of the functional results and varus-valgus stability in single-radius versus multi-radius femoral component for total knee arthroplasty.

recently, femoral designs based on a sagittal single radius were designed to allow better mid-flexion stability and extensor function after total knee arthroplasty. the purpose of this study was to compare mid-flexion stability and clinical outcomes in patients that received tka using either a single-radius femoral design or multi-radius femoral design.

Eligibility criteria:
inclusion criteria: * followed for a minimum of two years. exclusion criteria: * not followed for a minimum of two years.

Keywords: stability single-radius multi-radius total knee arthroplasty
quality of life in patients after pharyngolaryngectomy

Conditions: Laryngectomy; Status

Summary: laryngeal cancer is an indication for a laryngectomy (separation of the airways and digestive tract). laryngectomy causes a permanent disruption of self-perception. communication, social interactions, diet andaesthetic appearance are altered. its modifications disrupt the quality of life of patients and must be taken into account as soon as possible in patient cares.

the aim of the study is to describe quality of life in patients with laryngectomy.

Eligibility criteria:
inclusion criteria: * male or female * with laryngectomy * agreeing to participate in the study exclusion criteria: - less than 18 years old

Keywords: laryngeal cancer - laryngectomy - quality of life
maintenance of tarceva (erlotinib) in patients with locally advanced head and neck cancer

Conditions: Head and Neck Cancer

Summary: phase ii study of maintenance tarceva (erlotinib) in patients with locally advanced head and neck cancer after treatment with curative intent


Eligibility criteria:
inclusion criteria: * stage iii, iv scchn * completed curative treatment exclusion criteria: * prior chemotherapy or radiotherapy * recurrent disease

Keywords: squamous cell cancer of head and neck scchn
a study comparing tazarotene cream 0.1% to tazorac® and both to a placebo control in the treatment of acne vulgaris

Conditions: Acne Vulgaris

Summary: the purpose of this study is to evaluate the therapeutic equivalence and safety of tazarotene cream 0.1% and tazorac® (tazarotene cream 0.1%).

the purpose of this study is to evaluate the therapeutic equivalence and safety of tazarotene cream 0.1% and tazorac® (tazarotene cream 0.1%) in the treatment of acne vulgaris and to demonstrate the superiority of the test and reference products over the placebo control.

Eligibility criteria:
inclusion criteria: * healthy male or non-pregnant female aged ≥ 12 and ≤ 40 years with a clinical diagnosis of acne vulgaris. * subjects aged 18 years and older must have provided written consent. subjects aged 12 to 17 years must have provided written assent accompanied by written consent from their legally acceptable representative. all subjects or their legally acceptable representatives must sign health insurance portability and accountability act authorization. * must have a minimum of ≥ 25 non-inflammatory lesions and ≥ 20 inflammatory lesions and ≤ 2 nodulocystic lesions at baseline on the face. * must have a definite clinical diagnosis of acne vulgaris severity grade 2, 3, or 4 as per the investigator's global assessment. exclusion criteria: * female subjects who are pregnant, nursing or planning to become pregnant during study participation. * have a history of hypersensitivity or allergy to tazarotene, retinoids and/or any of the study medication ingredients. * presence of any skin condition that would interfere with the diagnosis or assessment of acne vulgaris.