Kornimate/medical-research-clean huggingface dataset:
bone health after bariatric surgery in patients with type 2 diabetes

Conditions: Bariatric Surgery; Bone Health; Obesity, Morbid; Diabetes Mellitus, Type 2

Summary: background: bone fragility is a complication of type 2 diabetes. diabetes treatments may ameliorate or deteriorate bone fragility in this population. bariatric surgery is gaining in popularity in people with type 2 diabetes and may impact bone health. objectives: to evaluate the impact of the most popular bariatric procedure worldwide (sleeve gastrectomy (sg)) on vbmd by qct in patients with type 2 diabetes; secondary aims: (1) to identify the determinants of vbmd after bariatric surgery in patients with type 2 diabetes; (2) to compare vbmd and its potential determinants after bariatric surgery with obese controls without diabetes as well as with controls without obesity and normoglycemia.

this is a multicentre, prospective and observational study comprising a bariatric group with or without diabetes undergoing sg (n=70) and one control group (n=30). outcome measures are assessed before and at 4 months, 8 months, one year and 3 years after surgery in the bariatric groups and at a single visit for the control group. bariatric groups will include adult men and women with or without type 2 diabetes and obesity undergoing sleeve gastrectomy and followed at 0, 4 months, 8 months, 1 year and 3 years after surgery, and the control group will consist of 30 overweight individuals (10 men, 10 premenopausal women, 10 menopausal women) and without diabetes or prediabetes and assessed at a single visit.

Eligibility criteria:
inclusion criteria: * bariatric groups: men and women; 18 to 60 years old; with a bmi \>=35 kg/m2; with type 2 diabetes: use of oral hypoglycemic agents or insulin or 2 of the following tests confirming type 2 diabetes: hba1c \>=6.5%; fasting glucose \>=7.0 mm; 2-h glucose post 75g oral glucose tolerance test (ogtt) \>=11.1 mm) (guidelines.diabetes.ca);) or without diabetes: hba1c \<6.5% and fasting glucose \<7.0 mm; who are awaiting bariatric surgery. control group: bmi 25.0 to 29.9 kg/m2 (overweight group); without diabetes or prediabetes: hba1c \<6.0% and fasting glucose \<6.1 mm (diabetes canada criteria), with a stable weight for the last 3 months. exclusion criteria: * bariatric groups: type 1 diabetes; disease (e.g. uncontrolled thyroid disease, malabsorptive or overt inflammatory disorder, metabolic bone disease, creatinine clearance \ 60 kg/m2; ct scan impossible to perform (e.g. patient too large for the gantry aperture); pregnant women or women who plan to become pregnant during the study or women of childbearing age who do not agree to take an appropriate contraceptive method during the study; history of oesophageal, gastric or digestive surgery; history of bariatric surgery; cancer at risk of recurrence during the study; prosthesis that could interfere with interpretation of imaging data; chronic severe condition or illness precluding from participation in the project. control group: same criteria plus: \>5% change in weight in the last 3 months; pregnancy or lactation in the last year.
lifestyle education and nutrition demonstration

Conditions: Chronic Disease

Summary: the center for lifestyle medicine at the cleveland clinic wellness institute has a proven track record of engaging patients in healthy living and eating through education, live cooking demonstrations / hands-on cooking classes, exercise and stress management programs. as a result of the community health needs assessment, we are collaborating with cleveland clinic community outreach and 12th district representative, john e. barnes, jr., to extend our expertise to the community of warrensville heights, ohio.

the city of warrensville heights and the cleveland clinic are combining efforts to address the paucity of fresh and nutritious foods accessible to seniors in the warrensville heights community through a new program at the city's civic and senior center. this program will combine healthy lifestyle education with nutrition demonstration using recipes that can be prepared in a blender. these recipes have been designed to be simple, delicious and easy to eat, and include smoothies, soups and even a few desserts! our ultimate goal is to use both education and demonstration to promote a mindset change regarding community members' abilities to eat healthy. the population in the warrensville heights community is aging, and there is a high prevalence of chronic diseases including hypertension, diabetes, obesity and kidney disease. a recent community health needs assessment (chna) identified engagement and participation in the promotion and maintenance of a healthy lifestyle as a major area for improvement. currently there is very limited access to healthy foods in the immediate community of warrensville heights, and in many cases, the transportation costs required for residents to access those healthy foods is often financially unfeasible. it is clear from this chna that both access to and education about healthy food options is sorely needed in this community. the center for lifestyle medicine at the cleveland clinic wellness institute has a proven track record of engaging patients in healthy living and eating through education, live cooking demonstrations / hands-on cooking classes, exercise and stress management programs. in response to the chna and in collaboration with 12th district representative, john e. barnes, jr., the blends study will extend our expertise to the warrensville heights community.

Eligibility criteria:
inclusion criteria: 1. adults 55 years of age or older living in the neighborhoods of warrensville heights exclusion criteria: 1. food allergies 2. celiac or non-celiac gluten intolerance 3. travel plans that do not permit full participation in the intervention 4. recent unexplained weight loss (10 pounds or more in past 3 months)

Keywords: lifestyle nutrition cooking
endoscopic mini/less open sublay(emilos) repair

Conditions: Hernia, Ventral

Summary: ventral hernias in the midline of the abdominal wall are one of the most frequent diseases in general and visceral surgery worldwide. the optimal operative technique is still in discussion. the traditional techniques are open sublay or transabdominal intraperitoneal onlay mesh (ipom) repair. in order to avoid the risks -large trauma to the abdominal wall with pain and infection, lesion of intraabdominal organs - a new hybrid technique - small skin incision, wide endoscopic dissection of the retrorectus space with implantation of a large mesh - was developed (emilos -endoscopic mini/less open sublay).

long-term results in 174 patients with a ventral hernia of the abdominal wall after emilos (endoscopic mini/less open sublay) repair. the worldwide most frequently used surgical techniques to repair ventral abdominal wall hernias are the open sublay operation and the transabdominal ipom (intra-peritoneal onlay mesh) technique. therefore a special questionnaire was developed to send to the patients to evaluate long-term outcome.

Eligibility criteria:
inclusion criteria * patients with clinical diagnosis of primary or secondary hernia in the midline of the abdominal wall * defect size must be between 2 and 10 cm in width associated with a weak abdominal wall(rectus diastasis) * patient must be suitable for general anesthesia * patient must have given informed consent * patient must be able to understand the principles of operation * patient must agree to be incluuded in a follow-up program and to be documented in herniamed registry exclusion criteria: * patients below 18 years of age * patients with a defect size below 2 cm * patients presenting with loss of domain * patients not be able to tolerate general anesthesia * patients presenting with excess skin tissue

Keywords: umbilical hernias-incisional hernias-emilos- .
combined ultrasound and fluoroscopy-guided technique for anterior hip denervation

Conditions: Hip Fractures

Summary: hip fracture is a challenging geriatric problem for health care professionals, especially in patients with multiple comorbidities. in patients with inoperable hip fractures secondary to severe comorbid conditions, the pain can lead to significant challenges in nursing care. a recent anatomical study confirmed the innervation of the anterior hip by these 3 main nerves but also found that the aon and fn play a greater role in the anterior hip innervation than previously reported.

the aim of this study is to help to target a suggested optimum landmark and determine the volume of injectate that can cover the distribution of the anterior articular branches supplying the hip joint. the anterior hip capsule is innervated by the on, accessory obturator nerve (aon), and fn as reported by previous anatomic studies. the anterior capsule is the most richly innervated section of the joint. ultrasound-guided technique for blockade of these articular branches to the hip, the peng (pericapsular nerve group) block reported significantly reduced pain scores compared with baseline. with the current understanding of the complex innervations of the hip joint, it is difficult to provide complete effective radiofrequency ablation to the articular branches supplying the hip joint. chemical hip denervation using ultrasound was reported by previous case reports or series without mentioning a well-defined target point or an optimum injectate volume.

Eligibility criteria:
inclusion criteria: * asa physical status i, ii, and iii. * patients scheduled for elective or emergent hip fractures. exclusion criteria: * patient refusal. * neuromuscular diseases (as myopathies, myasthenia gravies...) * hematological diseases, bleeding, or coagulation abnormality. * psychiatric diseases. * local skin infection and sepsis at the site of the block. * known intolerance to the study drugs. * body mass index \> 40 kg/m2. * multiple trauma patients.
effect of citric acid demineralization on autogenous bone blocks consolidation in humans

Conditions: Alveolar Bone Atrophy; Bone Resorption

Summary: this study evaluates the effect of citric acid demineralization in autogenous bone blocks consolidation. half of participants will receive citric acid treatment at the bone block and recipient site. other half will receive no demineralization treatment.

autogenous bone grafts are indicated in areas where there is not enough bone height and/or width for implant installation. treatment of bone surfaces with citric acid, promote a slight demineralization on surface that mimic natural processes of bone demineralization by osteoclasts. thus, this treatment could accelerate the process of autogenous bone block consolidation to its recipient site.

Eligibility criteria:
inclusion criteria: * presence of atrophic anterior maxilla (width 1.5 to 4 mm) * absence of active periodontal disease. * enough bone width on donor sites (oblique line or ment) exclusion criteria: * systemic disease that impede surgical procedure as blood diseases, endocrine diseases, impaired coagulation * smokers * pregnant women * patients receiving radiotherapy or chemotherapy * patients using bisphosphonates
pilot study: utilizing manometry to assess radiation-induced changes in esophageal function

Conditions: Lung Cancer

Summary: the purpose of this study is to prospectively assess the feasibility of high-resolution manometry to identify radiation-induced changes in esophageal motility and contractility or "function" in patients undergoing radiation therapy for the treatment of locally advanced lung cancer.

as there is no standard of care to evaluate/visualize the effects of radiation therapy (rt) -induced esophageal injury, this is routinely assessed by patient reported accounts, and the symptoms are then managed supportively (e.g. with pain medicines, parenteral nutrition, feeding tubes etc). manometry has been frequently used to study the effects of rt on gastrointestinal function in the setting of numerous malignancies, including colorectal, cervical and prostate cancers. what is often seen after rt is decreased sphincter function in the anorectal region leading to problems with continence and fecal urgency, however there has not been as rigorous of an evaluation of esophageal function after rt. one study performed more than 15 years ago included only 4 patients with lung cancer and concluded that mucosal irritation was likely the primary cause of rt-associated esophageal injury and no abnormalities in motility were seen. radiation is known to cause long-term esophageal injury including stricture, and there is manometric evidence of impaired motility long-term after rt. the recent introduction of high-resolution manometry permits more extensive evaluation of the effects of rt on esophageal function.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years or older * absence of any severe disorders of esophageal motility (patients with reflux and/or a hiatal hernia are eligible) * histologically confirmed lung cancer scheduled to undergo conventionally fractionated radiation treatment * patients that will be treated with a minimum of 45 gy of radiation therapy * patients with mediastinal nodal disease, or primary lesions that are near the esophagus are eligible provided that they are not having esophageal symptoms believed to be due to the tumor. exclusion criteria: * history of esophageal motility disorder that pre-dates and is unrelated to the present diagnosis of lung cancer * history of any prior radiotherapy to the esophagus * pregnant or lactating women * inability to understand and follow swallowing instructions for the esophageal manometry procedure; this is to ensure patient compliance of performing the breath hold technique throughout the radiation therapy treatment * patients with mediastinal nodal disease, or primary lesions, that are having esophageal symptoms believed to be due to the tumor

Keywords: lung cancer
study of gene expression profiling and immunological mechanism affects the response of immunotherapy

Conditions: Malignant Tumor

Summary: to investigate gene expression profile and immunological associated analysis relating to immunotherapy response of patients with malignant tumor presenting malignant cavity effusion after dc-cik immunotherapy.

1. the patients with malignant cavity effusion are treated with dendritic cells (dc) plus cytokine induced killer cells (cik) locally. 2. malignant cavity effusion from cancer patients is obtained through puncture and is centrifugalized to get supernatant fluid and enrich cancer cells before and after the therapy. 3. the enriched cancer cells which are flash frozen, as well as the supernatant, are stored at -80°c until processing. 4. the t-cell receptor/b-cell receptor gene expression in cavity effusion is detected by micro-array to explore the mechanism that dc-cik immunotherapy controls the malignant cavity effusion. 5. statistical analysis is performed using unsupervised hierarchical cluster.

Eligibility criteria:
inclusion criteria: 1. histologically confirmed with malignant tumor and malignant cavity effusion. 2. an eastern cooperative oncology group（ecog）performance status of 0-2. 3. normal cardiac, hepatic, renal and bone marrow functions. 4. life expectancy \>3 months. 5. not receive other anti-tumor treatment. 6. not receive chemotherapy in pleural and abdominal cavity. exclusion criteria: 1. previous history of other malignancies. 2. serious or uncontrolled concurrent medical illness.
efficacy testing of vecollal products

Conditions: Skin Condition

Summary: to assess vecollal formula on skin condition improvement


Eligibility criteria:
inclusion criteria: * healthy adults aged above 20 years old exclusion criteria: * subject who is not willing to participate in this study. * patients with diseases of the skin, liver, kidney. * subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder. * female who is pregnant or nursing or planning to become pregnant during the course of the study. * received facial laser therapy, chemical peeling or uv overexposure (\> 3 hr/week) in the past 4 weeks. * constant drug use * students who are currently taking courses taught by the principal investigator of this trial.
sb17170 phase 1 clinical trial in solid tumors

Conditions: Solid Tumor

Summary: phase 1 open-label, multicenter, dose escalation, dose expansion study

this is an open-label, multicenter, phase 1 clinical trial to evaluate the maximum tolerated dose, safety, pharmacokinetic/pharmacodynamic characteristics and preliminary anti-tumor activity of sb17170 when administered alone(1a) and co-administered with standard of care(1b) to patients with locally advanced or metastatic solid tumors who have failed standard of care. 1 cycle of treatment of this clinical trial is 21 days, and tumors are assessed every 2 cycles.

Eligibility criteria:
inclusion criteria: * a patient with a histologically or cytologically confirmed diagnosis of locally advanced or metastatic solid tumors. * a person who has failed the known standard of care or has developed resistance to the standard of care and no longer has applicable standard of care * a patient with at least one measurable lesion according to the recist v1.1 criteria. * a person with eastern cooperative oncology group (ecog) performance status of 0 or 1. * those with an expected survival period of 3 months or more at the discretion of of the investigator. exclusion criteria: * a patient who has received drugs targeting high mobility group box 1 (hmgb1). * a patient who has received or is undergoing chemotherapy (including chemotherapy, radiation therapy, immunotherapy, hormone therapy, targeted therapy, biological products, and tumor embolization) within 28 days from the first administration date of the investigational drug. * a person who needs to take contraindicated drugs or is expected to take them during the study period.
a pilot study of a trauma-sensitive mindfulness and compassion intervention

Conditions: Complex Post-Traumatic Stress Disorder

Summary: this mixed-methods pilot study aim to assess the changes in symptoms of post-traumatic stress disorder (ptsd), complex post-traumatic stress disorder (cptsd), dissociative symptoms, self-critique, and self-compassion following participation in a 16-week trauma-sensitive mindfulness and compassion (tmc) intervention. adverse experiences of participation are also explored explicitly.

seventeen clients most female with severe childhood abuse and ptsd and cptsd participated in the tmc intervention. a mixed-methods design was used. all clients completed questionnaires before (pre) and after (post) the intervention to gain information on symptom change, self-critique, and self-compassion. second, a qualitative interview addressing clients' experiences of participation, including an explicit focus on adverse experiences, was conducted.

Eligibility criteria:
inclusion criteria: * report traumatic experiences and trauma related symptoms * be between 18 and 65 years of age * give informed consent to participate in the study exclusion criteria: * acute suicidality * serious psychotic symptoms * substance abuse interfering with treatment * crisis interfering with treatment * violent behavior

Keywords: mindfullness treatment compassion trauma
study of thyroid status in patients with ibd

Conditions: Thyroid Disease; Irritable Bowel Disease

Summary: . the aim of the present study is to study thyroid state in patients with ibd

all patients were subjected to history taking and physical examination with emphasis on history of autoimmune disease, extraintestinal manifestations of ibd, neck examination for goiter, symptoms and signs of thyroid dysfunction. b) laboratory investigations: thyroid function test (include t3-t4- tsh) * esr - crp - thyroid antibodies: (anti tpo -anti thyroglobulin) c)-imaging: * neck u/s on thyroid gland to identify patients with ultrasonographic evidence of autoimmune thyroiditis (diffuse hypoechogenicity or heterogenicity echotexture or both) and to detect thyroid nodularity. d ) endoscopic findings regarding diagnosis of ibd confirmed by histopathological examination

Eligibility criteria:
inclusion criteria: all patients with ibd - exclusion criteria: * patients with * thyroid disease * acute or chronic kidney * acute or chronic liver disease. active lupus - * malignancy * patients taking medications that affect thyroid function as rifampin, amiodarone .....
multifunctional nutrition tube in dysphagia for nasopharyngeal carcinoma

Conditions: Dysphagia

Summary: baseline information (demographics, medical history, etc.), nutritional status at admission and after treatment, depression, dysphagia, and quality of life (qol) after treatment as well as adverse events are compared. palliation to delayed dysphagia after radiotherapy for nasopharyngeal carcinoma (npc) continues to be a challenge. although nasogastric tube feeding (ngt) has been adopted widely, the weaknesses have yet to be improved by another enteral nutrition support mode. this study aims to observe the clinical efficacy of intermittent oro-esophageal tube feeding (ioe) in the treatment of delayed dysphagia after radiotherapy for (npc). this is a prospective multicenter study with patients with delayed dysphagia after radiotherapy for npc. patients enrolled are randomly divided equally into the observation group and the control group. all patients receive conventional care, and the observation group received ioe while the control group received ngt for enteral nutrition support.

palliation to delayed dysphagia after radiotherapy for nasopharyngeal carcinoma (npc) continues to be a challenge. although nasogastric tube feeding (ngt) has been adopted widely, the weaknesses have yet to be improved by another enteral nutrition support mode. this study aims to observe the clinical efficacy of intermittent oro-esophageal tube feeding (ioe) in the treatment of delayed dysphagia after radiotherapy for (npc). this is a prospective multicenter study with patients with delayed dysphagia after radiotherapy for npc. patients enrolled are randomly divided equally into the observation group and the control group. all patients receive conventional care, and the observation group received ioe while the control group received ngt for enteral nutrition support. baseline information (demographics, medical history, etc.), nutritional status at admission and after treatment, depression, dysphagia, and quality of life (qol) after treatment as well as adverse events are compared.

Eligibility criteria:
inclusion criteria: * age between 18 and 65 years. * with the history of npc and radiation therapy. * with dysphagia occurred at least three years after radiotherapy * conscious and with stable vital signs; * willing to participate and sign the written informed consent form either personally or by a family member. exclusion criteria: * presence of other diseases that might cause dysphagia. * with distant metastasis of tumors, or complicated with severe systemic disorders or malignancies. * concurrent participation in other treatments that could interfere with the trial. * inability to cooperate with treatment due to aphasia, mental health issues, etc. * received tube feeding for enteral nutrition support within the past three years.