Kornimate/medical-research-clean huggingface dataset:
clinical reminders in test reports to improve guideline compliance

Conditions: Heart Failure, Congestive

Summary: although beta-blockers are known to prolong survival for patients with reduced left ventricular ejection fraction, their use in the community and the va is suboptimal.

background: although beta-blockers are known to prolong survival for patients with reduced left ventricular ejection fraction, their use in the community and the va is suboptimal. objectives: to determine if a reminder attached to the echocardiography report would increase the use of beta-blockers among patients with depressed left ventricular function. methods: we are randomizing consecutive patients undergoing echocardiography at one of three va echocardiography laboratories with reduced left ventricular ejection fraction (\<40%) and no echocardiographic contraindication to beta-blockers (e.g. aortic stenosis) to a reminder for use of beta-blockers or to no reminder. the reminder gives starting doses for two commonly used beta-blockers (carvedilol and metoprolol). patients are excluded from the analysis if they leave the health care system or die within three months of randomization. the primary outcome is a prescription for a beta-blocker between three and nine months following echocardiography status: the project is complete.

Eligibility criteria:
inclusion criteria: those undergoing echocardiography at one of the participating laboratories with an ejection fraction \< 45%. exclusion criteria: aortic stenosis, mitral stenosis
mk-5442 in the treatment of osteoporosis in postmenopausal women previously treated with an oral bisphosphonate (mk-5442-012)

Conditions: Osteoporosis; Postmenopausal Osteoporosis

Summary: this study seeks to demonstrate that additional gain in bone mineral density (bmd) can be achieved by switching to mk-5442 from an oral bisphosphonate in participants who have been receiving oral bisphosphonate therapy for at least 3 years.

the study was originally planned for a duration of 2 years and included efficacy analysis of a 15 mg mk-5442 treatment arm. amendment 1 of the protocol eliminated the 2nd year of the study as well the 15-mg arm. enrollment into the 15-mg mk-5442 arm was stopped as a result of the amendment and all participants who had been randomly assigned to the mk-5442 15-mg treatment arm were discontinued from the study.

Eligibility criteria:
inclusion criteria: * taking oral bisphosphonate treatment for osteoporosis for at least 3 of the past 4 years. at present, and for the past 12 months, treated with alendronate * bone mineral density (bmd) t-score that is ≤ -1.5 at one or more of the following anatomic sites; lumbar spine, femoral neck, trochanter, and total hip, and a bmd t-score at all of these sites that is ≥ -4.0, and a history of at least one fragility fracture, or, a bmd t-score that is ≤ -2.5 at one or more of the following anatomic sites; lumbar spine, femoral neck, trochanter, and total hip, and a bmd t-score at all of these sites that is ≥ -4.0 * postmenopausal for at least 5 years exclusion criteria: * obesity (ie, weight greater than 250 pounds) that prohibits the use of dual-emission x-ray absorptiometry (dxa) * received intravenous (iv) bisphosphonates, fluoride treatment at a dose \>1 mg/day for more than 2 weeks, strontium, growth hormone, a cathepsin k (ctsk) inhibitor, or a receptor activator of nuclear factor kappa-b ligand (rankl) inhibitor at any time in the past * use of oral bisphosphonates other than alendronate in the last 12 months, parathyroid hormone (pth) in the last 24 months, cyclosporin for more than 2 weeks in the last 6 months, heparin in the last 2 weeks, or anabolic steroids or glucocorticoids for more than 2 weeks in the past 6 months * use of estrogen with or without progestin or a selective estrogen receptor modulator (serm) in the last 6 months or calcitonin in the last 30 days * has used pioglitazone hydrochloride or rosiglitazone hydrochloride in the last 6 months * taking more than 10,000 international units (iu) vitamin a daily or more than 5,000 iu vitamin d daily * has had a total thyroidectomy * history of paget's disease * has human immunodeficiency virus (hiv) * history of cancer in the last 5 years, except certain skin or cervical cancers * history of major upper gastrointestinal (gi) mucosal erosive disease * unable to adhere to dosing instructions for alendronate in regard to fasting and positioning * not ambulatory
rock steady boxing vs. sensory attention focused exercise

Conditions: Parkinson Disease

Summary: this study evaluates the effect on rock steady boxing (rsb) and pd safex on parkinson's disease.

both interventions produce benefits to the pd population. pd safex has been proven to improve the motor symptoms of pd. however, research still needs to be conducted on the pd specific benefits associated with rsb. as such it an rct is necessary to compare the effects of both interventions.

Eligibility criteria:
inclusion criteria: * must be able to understand verbal instructions in english * diagnosed with idiopathic pd by a neurologist exclusion criteria: * if diagnosed with a neurological condition other than pd * if participated in an exercise program at least 2-weeks prior to the start of the study
evaluating the effects of tasimelteon vs. placebo on jet lag type insomnia

Conditions: Jet Lag Type Insomnia

Summary: the aim of this study is to investigate tasimelteon vs. placebo on sleep in healthy individuals after a phase advance in jet lag type insomnia.


Eligibility criteria:
inclusion criteria: * ability and acceptance to provide written consent, fluent in english; * healthy subjects with no medical, psychiatric or current sleep disorders; * men or women between 18-75 years; * body mass index of ≥ 18 and ≤ 30 kg/m2. exclusion criteria: * major surgery, trauma, illness or immobile for 3 or more days within the past month; * pregnancy or recent pregnancy (within 6 weeks); * a positive test for drugs of abuse at the screening or evaluation visit.
impact of health education learning package against intestinal parasitic infections among orang asli children

Conditions: Intestinal Parasitic Infections; Knowledge, Attitudes, Practice

Summary: a health education learning package (help) has been improved and evaluated for its impact against intestinal parasitic infections among orang asli schoolchildren in west malaysia. 13 schools were allocated into two groups (intervention and control groups) and the impact of help was evaluated after 3 and 6 months of baseline assessment and help intervention.

this study was conducted to evaluate the impact of an improved health education learning package (help) against intestinal parasitic infections among orang asli schoolchildren in west malaysia. the package has been tested by a pilot study in 2013 among children in 2 schools in pahang state. in the current study, help package has been improved and children from 13 primary schools in 11 districts of six states in peninsular malaysia were allocated into two groups (intervention and control groups) and the impact of help was evaluated after 3 and 6 months of baseline assessment and help intervention. the evaluation involved soil-transmitted helminth infections and intestinal protozoa infections.

Eligibility criteria:
inclusion criteria: * grade 2 - 6 * orang asli ethnicity * schools exclusively for orang asli exclusion criteria: * grade 1 * chronic sever diseases * no consent * schools for mixed population groups

Keywords: intestinal parasitic infections soil-transmitted helminth infections health education
analysis of the effect of intravitreal dexamethasone injection on diabetic macular edema after cataract surgery (iddmecs)

Conditions: Diabetes; Macular Edema; Pseudophakia

Summary: macular edema (swelling of a particular site of the retina) can become a significant problem for diabetics undergoing cataract surgery. and a significant number of people who undergo cataract surgery each year are diabetics. and when you multiply these two factors together you are left with a significant number of people who do not gain as much vision as their peers. diabetics who develop macular edema actually can loose some vision after surgery and when you follow them up, they don't gain as much vision. this study aims to prevent such an event from happening and therefore allow diabetics to gain as much vision as they can from cataract surgery. this study will use dexamethasone injected intravitreally (into the gel of the eye) at the end of cataract extraction to control macular edema brought about by surgery. the main outcome is the central retina thickness and retinal volume as measured by optical coherence tomography. secondary outcomes are bcva and incidence of laser treatment. other drugs, life bevacizumab and pegaptanib, have been used for this purpose but they are expensive and have potential systemic side-effects due to anti-vegf (vascular endothelial growth factor) actions. dexamethasone has been used in the eye for decades and is short-lived, minimizing possible systemic effects. moreover, this drug is at least 15x cheaper than the previously mentioned ones and therefore has tremendous benefit for developing countries. we seek an alternative drug that can reduce or prevent macular edema at a less expensive and safer way.


Eligibility criteria:
inclusion criteria: * diabetic patients for cataract surgery with vision of ≤ 20/50 and \> grade 3 any cataract type using the lens opacities classification system iii. diabetics included must have at least one microaneurysm in the posterior pole (defined by the superior and inferior arcade). exclusion criteria: * without any diabetic retinopathy and those with active uncontrolled proliferative disease * retinal disease,other than diabetes, that can affect macular edema * uveitis, a history of any other intraocular surgery or a history of uncontrolled glaucoma * eyes with cataract precluding proper oct measurement pre-operatively * patients who will experience longer than usual operating time, complicated surgery, rupture of the posterior capsule, and iris or corneal burns

Keywords: diabetic macular edema pseudophakic dexamethasone intravitreal cataract surgery
study on the transfusional management of the patients with congenital heart disease carried out in adulthood.

Conditions: Congenital Heart Defect

Summary: surgeries of heart disease in adulthood can happen in two specific contexts: * either for an asymptomatic anomaly, possibly coupled with the onset of symptoms later in life and tardily diagnosed and surgically managed * either for a malformation treated in childhood and requiring a new intervention in adulthood. in recent years, the number of adult patients with congenital heart disease has been steadily increasing. advances in diagnostic techniques and surgical treatments have enabled many children to reach adulthood. the number of these patients is now higher than the number of children with congenital heart disease. the number of these patients having had surgery in adulthood is also increasing. congenital cardiopathies are numerous, ranging from simpler pathologies such as inter-auricular or inter-ventricular communication, to much more complex pathologies such as situations of univentricular hearts. the surgical treatments of these congenital heart diseases are classified into three groups: initial palliative surgery, initial curative surgery or iterative surgery. palliative surgery aims to improve the clinical tolerance of the patient to the conditions of his pathology or to prevent complications. the curative surgery restores the physiological circulation, the iterative surgery treats a complication or a degeneration appearing after a curative surgery. patients undergoing cardiac surgery frequently receive blood products transfusions during the preoperative, intraoperative, or postoperative periods. several observational studies have shown that in cardiac surgery, the transfusion of blood derivatives is associated with an increase in post-operative morbidity and mortality. the objective of this study is to analyze the predictive factors of transfusion in congenital patients operated in adulthood at brugmann university hospital, depending on the type of surgery applied (palliative, curative or iterative). the secondary objective will be to assess whether there are any differences with the predictive factors identified in non-congenital patients undergoing cardiac surgery, which could potentially alter the transfusion approach in congenital patients.


Eligibility criteria:
inclusion criteria: cardiac surgery linked to the presence of a heart congenital malformation. exclusion criteria: transfusion refusal from the patient

Keywords: congenital heart disease blood products transfusion
telerehabilitation in women with rheumatic disease

Conditions: Rheumatic Disease

Summary: this study aims to investigate the effectiveness of the biopsychosocial exercise therapy approach (bety), which is a biopsychosocial model, on daily living activities, anxiety, depression, and biopsychosocial conditions through telerehabilitation in rheumatic patients who could not go to the clinics during the covid-19 pandemic.

35 female participants with rheumatic disease were included in the study. among the individuals who participated in face-to-face bety sessions before, 23 individuals who agreed to exercise with telerehabilitation were divided into 2 groups, the exercise group, and 12 individuals in the control group. group 1: telerehabilitation group: individuals in the telerehabilitation group attended sessions that lasted for one and a half hours, 3 days a week for 8 weeks, in the company of a physiotherapist over the whatsapp group. the investigators, who provided supervision during the sessions, also participated in the exercises simultaneously. the investigators managed the individuals according to their exercise number and order, by reminding them of the exercises with explanatory messages and positive energy via whatsapp group. the participation of the patients in the exercises was followed up with the answers they gave in the whatsapp group. patients who did not respond were called by phone and checked to see if they provided continuity. both the exercise group and the control group continued their drug treatments during this period. group 2: control group: individuals in the control group continued their routine drugs.

Eligibility criteria:
inclusion criteria: * participants diagnosed with rheumatic disease, * participants knew the exercises before attending bety sessions, * participants who could participate in telerehabilitation by following whatsapp communication were included in the exercise group. exclusion criteria: * participants with neurological and psychological disorders, * severe respiratory failure, fractures, infections, cancer, and musculoskeletal pain due to surgery in the last 6 months, * vision loss, * pregnancy * participants who did not agree to volunteer were not included in our study.

Keywords: rheumatic diseases telerehabilitation chronic pain covid-19 biopsychosocial approach
study on clostridium difficile infection in chinese patients with inflammatory bowel disease

Conditions: Inflammatory Bowel Diseases; Clostridium Infections

Summary: in recent years, the incidence of inflammatory bowel disease (ibd) has been increasing in china, which poses great challenges and burdens to the medical community due to its unknown etiology, recurrence and incurability. co-infection is one of the important causes in ibd development. ibd accompanied with clostridium difficile infection (cdi) can significantly decrease the treatment efficiency, leading to increased surgical rate, increased mortality, prolonged hospital stay, and increased hospital costs. recently, several chinese clinical guidelines about ibd or cdi have been published, but these guidelines are mainly based on the foreign studies. compared with the developed countries, the lack of multi-center, large-scale and multi-test clinical trials and cohort studies caused limited understanding for ibd-cdi in china. therefore, it is of great importance to carry out the multi-center clinical trials and analysis on ibd-cdi to improve the diagnostic and therapeutic efficiency in ibd-cdi patients objective: 1. to evaluate the prevalence rate of ibd-cdi in chinese adults in china based on the multi-center clinical trials.. 2. to analyze the related risk factors of ibd-cdi in china based on the multi-center clinical trials. 3. to analyze the intestinal flora of ibd-cdi patients via high-throughput sequencing.


Eligibility criteria:
inclusion criteria: * 1.inpatients with diagnostic criteria for ulcerative colitis and crohn's disease in accordance with the consensus opinion on the diagnosis and treatment of inflammatory bowel disease in china in 2012 * 2.willing to participate in the study; * 3. have the ability to understand and sign informed consent. exclusion criteria: * 1.patients with infectious enteritis, intestinal tuberculosis, lymphoma, behcet's disease or other intestinal diseases except inflammatory bowel disease; * 2.pregnant or lactating women; * 3.severe circulatory system, respiratory system, blood system, immune system, urinary system and other combined diseases or serious psychosomatic diseases.
bacteriological study of diabetic foot and antibiotic sensitivity pattern in eastern india

Conditions: Diabetic Foot

Summary: the pattern of organism causing diabetic foot infection are presumed to vary from location to location depending on the antibiotic prescription practice, geographical locations, environmental variations and therapeutic interventions for various patients. our hypothesis is look to finding out common similarities with diversified subgroups spread across various geographical locations of eastern part of india, thus to create a data base for treating patient with diabetic foot infections.the sensitivity pattern is anticipated to be different from institution to institutions and place to place but the gross sensitivity data of local pathogen could guide physician for choosing right empirical antibiotic. practice guideline could be postulated from the collated data of distribution of pathogens, their sensitivity pattern as well as co-morbid conditions of the sufferers.


Eligibility criteria:
inclusion criteria: * diabetic foot patients with wagner's grade 2 or more foot infection.

Keywords: diabetic foot bacteriological epidemiology wagner's grading eastern india
patient satisfaction with contoura vision topography-guided lasik

Conditions: Myopia; Astigmatism

Summary: to evaluate patient reported outcomes associated with quality of vision before and after treatment with contoura vision topography-guided lasik.


Eligibility criteria:
eligibility criteria: the study enrollment will include all willing patients with: pre-operative bcva 20/20 for each eye individually, myopic refractive error up to -8.00 diopters, refractive astigmatism that ranges from 0 to 3 diopters, maximum spherical equivalent of -9.00 diopters, the designated age requirements, and only patients that have signed the informed consent document. exclusion criteria: patients are excluded that are not willing to participate in a research trial, are unable to cooperate well enough to safely perform the procedure, fail to meet inclusion criteria, have ocular disease (including but not limited to keratoconus, macular degeneration, glaucoma, corneal dystrophy, dry eye syndrome and corneal scarring), and patients that have had previous ocular surgery. any patients with known allergies to the post-operative medications or preservatives in the medications will also be excluded.
repetitive transcranial magnetic stimulation in fibromyalgia

Conditions: Fibromyalgia

Summary: the purpose of this study is to determine the analgesic effectiveness of repetitive transcranial magnetic stimulation (rtms) used as an additional procedure to rehabilitation exercises in patient suffering from fibromyalgia. a double blind clinical trial with two randomized parallel groups: * placebo rtms and rehabilitation exercise * active rtms and rehabilitation exercise

fibromyalgia is the most frequent chronic diffuse painful disease (3 to 4% of the general population). analgesic drugs are widely used in fibromyalgia, pain being the main symptom. however the effectiveness of analgesic drugs is often insufficient. among non-drug therapies, rehabilitation exercise plays an important role with a special interest in terms of the quality of life, strain and pain. more recently the transcranial magnetic stimulation effects have been evaluated in patients suffering from fibromyalgia with a statistically significative analgesic effect. both rehabilitation exercise and transcranial magnetic stimulation (rtms) have shown their respective analgesic effectiveness in fibromyalgia. it now seems important to evaluate the combination of these two therapies. main objective: to evaluate the analgesic effect of rtms in fibromyalgia patients doing rehabilitation exercise. primary endpoint: the evaluation methode used is a visual analog scale (vas) of pain. patients will note down every day vas of over the last 24 hours. the evolution of the vas during the treatment period with respect to baseline, will be compared in both groups, active rtms and placebo rtms. the investigators will analyze the average daily vas for different weeks (w2, w4, w8, w14) compared to the average daily vas at the baseline. after a baseline period of 15 days, patients will begin sessions of rtms and rehabilitation exercise for a period of 14 weeks. the study is composed of three assessment visits : a baseline visit, a visit corresponding to the end of the therapy with exercise period and a last assessment visit at 26 weeks after the end of the treatment. these visits will include clinical examination, blood test, an effort test, an orthostatic test, a resistance to fatigue test and polysomnography.

Eligibility criteria:
inclusion criteria: * primary fibromyalgia according to the american college of rheumatology * no contraindication to rehabilitation exercise * pain with vas \> 4 during at least six months * fiq score \> 50 * no change in drug therapy over the last month * affiliation to french health service exclusion criteria: * bmi \> 35kg/m² * patient who has already benefited from rtms * rtms contraindication * restless legs symptom * patient suffering from major depression * patient suffering from inflammatory rheumatism, autoimmune disease, other chronic pain pathology * sleep apnea syndrome * no contraindication to rtms or mri * pregnant women

Keywords: fibromyalgia pain repetitive transcranial magnetic stimulation rehabilitation exercise quality of life
a study to assess the efficacy of 3 months of latanoprost treatment in reducing the intraocular pressure in patients with ocular hypertension or open-angle glaucoma

Conditions: Glaucoma, Open-Angle; Ocular Hypertension

Summary: the purpose of this study is to evaluate the effect of latanoprost on intraocular pressure reduction in patients with ocular hypertension or open-angle glaucoma.


Eligibility criteria:
inclusion criteria: * a patient with an iop greater than or equal to 20 mmhg related to unilateral or bilateral oh or oag (primary open angle glaucoma, pseudo-exfoliative glaucoma, and pigmentary glaucoma), after a visual field exam * naive patients (i.e. never having been treated) and requiring treatment initiation exclusion criteria: * a patient with oh or oag currently on treatment * a patient with oh or oag previously treated (regardless of the date treatment was discontinued) * a patient with traumatic, inflammatory, or neovascular glaucoma