Kornimate/medical-research-clean huggingface dataset:
impact of nutritional intervention in indian female cancer cachexia patients

Conditions: Cachexia; Cancer

Summary: the main aim of the study is to assess the effectiveness of tailored nutritional intervention in delaying the progression of cachexia to refractory cachexia in adult female cancer patients. the tested hypothesis stated that intake of nutrient rich bread mix (along with dietary and physical activity counselling) for six months, improved the anthropometric and biochemical indices in free-living patients suffering from cancer cachexia.

patients were randomly distributed into two groups i.e. control and intervention group. 30 patients were allocated in intervention group and received nutrient rich bread mix i.e. iatta (100 g) along with dietary and physical activity counseling and 33 patients were allocated in the control group who received only dietary and physical activity counseling. patients in the intervention group collected 14 packets of 100 g of iatta every fortnight during their clinician appointments while the control patients were advised regarding their dietary habits at every clinician visit for 6 months. dietary counseling for 30 minutes was imparted to all patients on each visit by the researcher. depending on the physical status of the patients, low level of physical activity (walking and/or stairs), was encouraged daily during counseling sessions. nutritional, biochemical, quality of life and anthropometric estimations were assessed at baseline, after 3 months and at 6 months of intervention for all patients. patients' daily energy, carbohydrate, protein and fat intake were calculated using food frequency (indian migrant study food frequency questionnaire- ims-ffq) questionnaire and two day 24 hour recall data. pg-sga questionnaire was used to monitor patient nutritional status throughout the study. eortc-qlq- c30 questionnaire was used to analyse patients' quality of life and asked personally by the researcher. haemoglobin and serum albumin levels were assessed at the start of the study, after 3 months and at 6 months of intervention for all patients. indian migrant study physical activity questionnaire (ims-paq) was used to assess patients' physical activity throughout the day. anthropometric estimations included body weight, mid upper arm circumference and four site skin fold thickness (sft) measurement (i.e. triceps, biceps, subscapular and suprailiac).

Eligibility criteria:
inclusion criteria: * female, age 18 years and above. * diagnosed with cancer. * weight loss \>5% from pre-treatment weight or bmi\<20kg/m2. * hemoglobin level \<12 g/dl. * energy intake \< 1500 kcal/d (to be assessed on consultation). exclusion criteria: * incapable to provide written consent. * patient diagnosed with refractory cachexia. * life expectancy \< 3 months. * unresponsive to anti-cancer therapy. * patient is a pregnant woman or a nursing mother. * suffering from secondary illnesses. * gastrointestinal tract defects which affect nutrient absorption

Keywords: nutrition intervention palliative care public health quality of life tailored food formula body weight
international validation of a delirium prediction model for icu patients

Conditions: Delirium

Summary: recently our icu research group developed and validated a delirium prediction model in the netherlandsthis. this model has a high predictive value. we want to examine what the predictive value is in icus of other european countries.

delirium is a serious and common disorder in icu patients. it is increasingly recognized that screening of icu patients is a valuable tool for early detection and treatment of delirium, which may reduce its incidence, severity and duration. apart from treatment of delirium, delirium prevention (pharmacological and nursing interventions)is an important issue. however, it is time consuming to take preventive measures in all icu patients. the recently developed prediction model facilitates the conduct of preventive measures focused on high risk groups. this prediction model is developed and validated in the netherlands. the aim of our study is to investigate the predictive value of the model in icus in other countries.

Eligibility criteria:
inclusion criteria: * patients 18 years or older exclusion criteria: * delirious state within the first 24hours after icu admission * sustained comatose during complete icu stay * admission duration less than twelve hours; * serious auditory or visual disorders * unable to understand the language of the included centre * severely mentally disabled * serious receptive aphasia * or if there are missing or incomplete delirium screenings during admission to the icu
comparison of masticatory efficiency between complete denture with zero-degree teeth and anatomic teeth in patients with severely resorbed ridge

Conditions: Edentulous

Summary: this study aims to evaluate masticatory efficiency of the zero-degree teeth complete denture in treatment of edentulous patients of severely resorbed ridge.patients will be crossed over to be treated with zero-degree teeth complete denture and anatomic teeth complete denture. for each patient, the masticatory efficiency and electromyography with different denture will be recorded and analysis.


Eligibility criteria:
inclusion criteria: * complete edentulism for at least three months class ⅳ ridge exclusion criteria: * neuromuscular dysfunction, psychiatric disorder,
results following fresh-frozen humeral head osteochondral allograft reconstruction for reverse hill-sachs lesion

Conditions: Shoulder Dislocation Closed Traumatic

Summary: locked posterior glenohumeral dislocations with a reverse hill-sachs impaction fracture involving less than 30% of the humeral head are most frequently treated with lesser tuberosity transfer into the defect, whereas those involving more than 50% undergo humeral head arthroplasty. reconstruction of the defect with segmental femoral osteochondral allografts has been proposed to treat patients between these two ranges, but the medium-/long-term outcomes of this joint-preserving procedure are controversial.

twelve patients with a unilateral locked posterior shoulder dislocation and at least 30% (mean 31%) impaction of the humeral head were treated with segmental reconstruction of the defect with fresh-frozen humeral head osteochondral allografts. patients were assessed clinically, radiographically and with computed tomography (ct) at a medium follow-up of 66 months (range, 24-225).all twelve shoulders presented a slight limitation in anterior elevation

Eligibility criteria:
inclusion criteria: - diagnosis of an acute non-reducible posterior gleno-humeral dislocation with an associated mclaughlin lesion affecting more than 30% of the cartilaginous circumference of the humeral head. exclusion criteria: - patients with associated injuries to the affected upper limb, with neuromuscular or psychomotor disorders or with disorders affecting connective tissues.

Keywords: shoulder dislocation, humeral allograft, locked posterior dislocation
early administration of heparin at fmc for ppci of stemi patients

Conditions: STEMI; Primary PCI

Summary: heparin is the first choice of anticoagulation drug for primary pci of stemi patients. however, the priority of use of hepairn in first medical contact or in cathlab has not yet studied. previous study revealed early use of antithrombotic drugs could improve patient's survival. here we supposed that use of heparin at first medical contact could increase the timi flow 3 grade ratio in stemi patients and improve patient's survival and/or reduce mace rather than in cathlab.

this study will recruit 944 stemi patients undergoing primary pci with the symptom onset within 12 hours in 36 hospitals in hubei province, china. the patients will be 1:1 randomly assigned to the intervention group (ig) and control group (cg). patients in ig will be intravenously administrated with sodium heparin (100u/kg) at first medical contact, while patients in cg will be administrated with sodium heparin (100u/kg) through catheter sheath in the cathlab. inclusion criteria: stemi patient; symptom onset in 12 hours; intended to perform ppci. exclusion criteria:active bleeding; life expectancy less than 1 year; history of heparin-induced thrombocytopenia; mechanical complication of mi (vsr, acute mr); history of cabg; on coagulation drugs; cpr before randomization; pregnant or lactating woman;refused to sign the informed consent form.

Eligibility criteria:
inclusion criteria: * stemi patient; symptom onset in 12 hours; intended to perform ppci exclusion criteria: * active bleeding; life expectancy less than 1 year; history of heparin-induced thrombocytopenia; mechanical complication of mi (vsr, acute mr); history of cabg; on coagulation drugs; cpr before randomization; pregnant or lactating woman.

Keywords: heparin primary percutaneous coronary intervention st-elevation myocardial infarction
doxycycline in acute traumatic brain injury

Conditions: Traumatic Brain Injury

Summary: evaluate the impact of doxycycline on both clinical outcome and blood levels of nse in patients with tbi.

1. approval will be obtained from research ethics committee of faculty of pharmacy, damnhour university. 2. all participants agreed to take part in this clinical research and provide informed consent. for unconscious participants, the informed consent was obtained from their legally authorized representative. 3. patients with moderate to severe tbi will be enrolled from tanta university hospitals. 4. serum samples will be collected for measuring the biomarkers. 5. our design is randomized, controlled study. 6. all enrolled patients will be divided into 2 groups, group (1) 25 patients that receive doxycycline 100 mg twice daily, either orally or through a nasogastric tube for 5 days, and group (2) will be 25 patients will receive placebo in addition to the standard treatment. 7. all patients will be followed up during icu period. 8. statsicial tests appropriate to the study design will be conducted to evaluate the significance of the results. 9. measuring outcome: the primary outcome is the change in the serum level of acute brain injury biomarkers. 10. results, conclusions, discussion and recommendations will be given.

Eligibility criteria:
inclusion criteria: 1. hospital admission in the first 24 h of injury, 2. 18 to 90 years of age and 3. both sexes with moderate to severe traumatic brain injury (gcs score ≤ 12). 4. able to tolerate enteral feeding and drug administration within the first 24 hours of tbi exclusion criteria: 1. hypersensitivity to tetracyclines 2. pregnant and breast feeding women, 3. history of autoimmune disease. 4. history of receiving chronic steroid treatment and isotretinoin, 5. pre-existing hepatic (ast, alt greater than 3 times the upper limit of normal) or renal failure (bun/ creatinine 20:1; creatinine \> 2 mg/dl), 6. known malignancies
video-based delivery of hiv test information for spanish-speaking latinos

Conditions: HIV; AIDS

Summary: the purpose of the study is to determine if a spanish-language hiv and hiv test information video is as effective in delivering basic information regarding hiv and hiv tests to primarily spanish-speaking hiv test recipients as an in-person presentation with an hiv test counselor.


Eligibility criteria:
inclusion criteria: * 18-64 years of age * self-identify as latino * able to give informed consent * spanish speaking exclusion criteria: * intoxicated * being treated for acute psychiatric illness * mental incapacitation * significant visual or hearing impairment * prisoner or under home confinement * participating in hiv vaccine trial * critically ill

Keywords: hiv hiv prevention hiv testing hiv rapid test
spinal cord injury: endurance, strength and cardiac function induced by efficient training protocols

Conditions: Cardiovascular Disease

Summary: 1. measurements of peak oxygen uptake (vo2peak) during passive leg cycling (plc) combined with arm crank ergometry (ace), leg vascular occlusion (100mmhg above systolic bp) combined with ace, and fes isometric contractions combined with ace in spinal cord injured (sci). all the above mentioned parameters will be compared to functional electrical stimulated (fes) lower extremity cycling combined with ace (feshybrid). the hypothesis is that vo2peak is significantly higher during fes hybrid cycling when compared to peak and submaximal plc, leg vascular occlusion and ace. but the values for vo2peak during fes isometric contractions combined with ace is not significantly different from fes hybrid cycling. 2. comparison of sub-maximal and peak vo2 values during arm crank (ace) and wheelchair ergometry (wce) in persons with spinal cord injury. the hypothesis is that wheelchair propulsion due to higher energy expenditure show higher work output and vo2peak than ace. 3. does 6 weeks of maximal strength training improve sci subjects performance during wce? wce after 6 weeks maximal strength training is less strenuous owing to better work economy/ efficiency. 4. effect from aerobic high intensity hybrid training on stroke volume (sv) and vo2peak in spinal cord injured men. 8 weeks of high intensity 4 times 4 interval training at 85-90% of peak heart rate during hybrid cycling. hypothesis; vo2peak and sv will be significantly increased from training.


Eligibility criteria:
inclusion criteria: * paraplegia, sensorimotor complete injury ais a to motor complete, sensory incomplete ais b. chronic neurological state with stabile spontaneous recovery compared to baseline ais. at least year since injury. * be able to tolerate direct current stimulation in the means of fes * living in health region iv and v, norway. exclusion criteria: * pacemaker (demand type) * known cancer * known pregnancy * severe autonomic dysreflexia * gross contractures

Keywords: functional electrical stimulation cycling arm crank wheelchair ergometry paraplegia spinal cord injury exercise testing
myofascial induction effects on plantar pressures and stabilometry

Conditions: Foot Diseases; Myofascial Pain

Summary: the objective is to determine the effectiveness of myofascial induction effects on plantar pressures and stabilometry variables. forty healthy subjects (28 females and 12 males) will be recruited for a simple blind clinical trial. all subjects will be randomly distributed in two different groups: control group (sham treatment of myofascial induction) and experimental group (myofascial induction). outcome measurements will be foot plantar pressure area (footprint) and center of pressure area (stabilometry) by the balance evaluation systems test. two trials will be recorded for each condition.


Eligibility criteria:
inclusion criteria: * healthy individuals without pain. exclusion criteria: * previous lower extremities surgery * history of lower extremities injury with residual symptoms within the last year * evidence of a leg-length discrepancy of more than 1 cm * evidence of balance deficits
sclerostin and vascular calcification in ckd and renal transplant

Conditions: Vascular Calcification; Chronic Kidney Failure

Summary: the aim of the research is to determine the degree of vascular calcification in chronic kidney disease and post-transplant and whether there is a correlation with the level of serum sclerostin.

sclerostin is a 22-kda glycoprotein encoded by the sost gene. this glycoprotein is almost exclusively synthesized by osteocytes that are not present near the bone surface but lie in the mineralized cortical and cancellous bone (3). sclerostin can exert its inhibitory effects on bone formation by not only inhibiting proliferation, differentiation and function of osteoblast cells but also facilitating their apoptosis(4). wnt/β-catenin signalling pathway participates in bone homeostasis and diseases.(5,6) but beyond that, many lines of evidence derived from cell cultures and animal studies indicate that this signalling pathway plays a prominent role in the pathogenesis of atherosclerosis and vascular calcification(vc) (7-10). serum sclerostin levels in ckd patients are remarkably higher than those in the normal population, with their values increasing across the ckd stages(4,11). however; the studies on the association of serum sclerostin with vc and mortality in renal disease patients have yielded conflicting results. some investigations showed a positive correlation, whereas others suggested no or even negative correlation(12). vc occurs frequently in ckd patients and its incidence increases across the ckd stages (19). notably, vc is associated with cardiovascular events (cves) and poor prognosis in ckd. it is well recognized that vc occurs in the early years of kidney disease patients recently, even prior to the occurrence of disordered phosphate homeostasis.vc is recognized as a pathological process of osteogenesis initiated by inflammatory factors in vessels(20). the upregulation of sclerostin in calcified tissues led researchers and clinicians to come up with a hypothesis that sclerostin may be related to the pathogenic mechanism of vc in renal disease patients, leading to a large number of studies to examine the association between sclerostin and vc in ckd patients. however, these studies reported inconsistent results, with some studies showing positive association between sclerostin and vc in ckd patients,(21-24) whereas others showing negative association (25-28) or no association at all(29). as in ckd patients, kidney transplant recipients' (ktrs') vc strongly predicts cardiovascular events and all-cause mortality over conventional risk factors.

Eligibility criteria:
inclusion criteria: * chronic kidney disease stages 4 and 5 * renal transplant recipients exclusion criteria: * significant co-morbidity: advanced cancer, advanced liver disease, tertiary hyperparathyroidism
does the hyoscine n-butylbromide administered during colonoscopy increase the adenoma detection rate?

Conditions: Colonic Adenomas

Summary: the primary aim of the study was to test if the administration of hyoscine butyl bromide, at time of caecal intubation, increases the adenoma detection rate.

outpatients referred for colonoscopy were screened for possible enrollment. exclusion criteria included: glaucoma, benign prostatic hyperplasia or urinary obstruction, previous intestinal resection, ongoing therapy with tricyclic antidepressants, chronic renal failure and history of ibd. eligible patients were randomized to receive either 20 mg/2ml of hbb i.v. or 2ml of saline i.v.; both the endoscopist and the patient were blind to the administered drug. the endoscopist was asked to inspect the right, transverse and left colon for at least 2 min for each segment. the number, size and location of polyps were recorded as well as the occurrence episodes of tachycardia (defined as bpm\>140). as indirect estimation of the amount of air retained in the abdomen at the end of the procedure, the dac (difference in the abdominal circumference measured before and after colonoscopy) was also calculated. at discharge (at least 1 hour after colonoscopy) the bloating perceived by the patient was measured by means of a va scale (range 0-100).

Eligibility criteria:
inclusion criteria: * outpatients referred for colonoscopy exclusion criteria: * glaucoma * benign prostatic hyperplasia or urinary obstruction * previous intestinal resection, * ongoing therapy with tricyclic antidepressants * chronic renal failure * history of ibd * participation other studies * unsedated colonoscopy

Keywords: adenoma detection rate anti-spasmotic drug
combining lhu with ultrasound monitoring in iui

Conditions: Infertility

Summary: intra-uterine insemination (iui), generally in combination with ovarian stimulation, is one of the most commonly used treatments for infertility. accurate timing of insemination, in order to coincide with ovulation, has an important impact on the success rate. optimal timing of insemination is achieved either by monitoring follicular growth through serial ultrasound measurements followed by the administration of human chorionic gonadotropin (hcg) or by the detection of urinary luteinizing hormone (lh). however in cycles where follicular growth is monitored there is a possibility of premature lh rise before the administration of hcg, which may affect the outcome of the treatment. the goal of the study is to determine if adding the testing of urine lh in conjunction with ultrasound monitoring leads to an increase in pregnancy rates in iui cycles when compared to ultrasound monitoring alone.


Eligibility criteria:
inclusion criteria: * undergoing iui treatments for: * unexplained infertility (including endometriosis stage 1-2) * mild male factor (\>5x106/ml motile sperm as determined by total sperm concentration x % a+b motility in the latest spermogram) * donor insemination * natural or stimulated cycles with clomiphene citrate or letrozole * at least 1 patent tube on hysterosalpingogram, hysterosonogram or laparoscopy within the last two years * antral follicular count ≥10 and fsh\<10 exclusion criteria: * polycystic ovarian syndrome or any cause of oligo or anovulation * patients taking other infertility medication (metformin, 17b estradiol, progesterone or gonadotropins) * presence of an ovarian cyst or a follicle \>20 mm on the first ultrasound or any reason for immediate hcg administration * a previous sperm washing result with less than 5x106/ml motile sperm * previous inconclusive ulh test or inability to perform ulh testing

Keywords: intra uterine insemination
freestyle libre in pregnancy study

Conditions: Diabetes Mellitus

Summary: to evaluate the point accuracy of the freestyle libre flash glucose monitoring system when used at home by pregnant women with diabetes.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * type 1, type 2 or gestational diabetes mellitus (gdm) (confirmed diagnosis via oral glucose tolerance test (ogtt)) * currently testing blood glucose(bg), on average at least 2 times per day * participant is ≥12+0 weeks gestation with a singleton pregnancy * in the investigator's opinion, technically capable of using device exclusion criteria: * concomitant disease or condition that may compromise patient safety including and not limited to; cardiac disease or event, sickle cell disease, cystic fibrosis, severe mental illness, known or suspected eating disorder or any uncontrolled long term medical condition * currently receiving dialysis treatment or planning to receive dialysis during the study or, moderate to advanced nephropathy (serum creatinine ≥120 micromol/litre or total protein excretion exceeds 2 g/day or urinary albumin:creatinine ratio \>30 mg/mmol, estimated glomerular filtration rate (egfr) may not be used) * diabetic ketoacidosis (dka) (in the previous 6 months) * known (or suspected) allergy to medical grade adhesives * in the investigator's opinion the participant is unsuitable to participate due to any other cause/reason, considering guidelines (e.g. national institute for health and care excellence (nice) and international diabetes federation(idf)) for diabetes in pregnancy for hba1c and blood pressure * experiencing any of the following conditions for current pregnancy: * pre-eclampsia * hellp syndrome (haemolysis, elevated liver enzymes and low platelet count) * prescribed tocolytic drugs for treatment of preterm labour

Keywords: diabetes mellitus sensing technology