Kornimate/medical-research-clean huggingface dataset:
evaluation of the effect of oil pulling

Conditions: Oral Hygiene; Dental Plaque

Summary: the objectives of this study were to evaluate the inhibitory effect on plaque and the tooth discoloration associated with agents used in the chemical plaque control of oil pulling in comparison with chlorhexidine-containing mouthwash and water in a four-day plaque regrowth model. one hundred dentistry students were included in this randomized, parallel-group, placebo-controlled clinical study. in this study, participants were divided into 5 equal groups: group 1: gargling with 0.2% chlorhexidine; group 2: oil pulling with coconut oil; group 3: oil pulling with black cumin oil; group 4: oil pulling with terebinth oil; group 4: gargling with distilled water. participants were instructed to refrain from mechanical oral hygiene and rinse only with the allocated mouth rinse during the four-day period. the differences in plaque index, gingival index, and tooth discoloration were evaluated in the study.


Eligibility criteria:
inclusion criteria: * without systemic disease, * had at least 24 teeth, and * without fixed or removable prostheses or orthodontic appliances exclusion criteria: * individuals with a history of systemic or topical oral antimicrobial therapy use in the last 3 months * individuals with an allergy to any ingredient used in the study * smokers * pregnant or breastfeeding women * individuals with ≥2 mm gingival recession

Keywords: chlorhexidine oil pulling plaque regrowth model coconut oil digital spectrophotometer
the effect of a shaken baby syndrome prevention program

Conditions: Shaken Baby Syndrome; Mothers

Summary: objective: this randomized controlled study aims to examine whether the education program prepared to prevent shaken baby syndrome has an effect on mothers' knowledge and attitudes. method: simple randomization will be used to evaluate the intervention and control groups. the study will be carried out with 90 mothers babies of 2-4 months, who applied to akdeniz university hospital healthy child outpatient clinic (intervention group: 45, control group: 45). after the pre-test, the mothers in the intervention group will be trained and a booklet will be given. tele-consultancy service will be provided to mothers during the 2-month follow-up period. after 2 months of follow-up, a post-test will be applied to the mothers in the intervention group. the mothers in the control group will not be intervened after the pretest is applied. a post test will be applied 2 months after the pre-test. after the post-test, the mothers in the control group will be trained and a booklet will be given. ethics committee approval and institutional permission were obtained for the study. verbal and written consent will be obtained from the mothers during the data collection phase.

method: the study will be conducted with 90 mothers with 2-4 months old babies who applied to akdeniz university hospital healthy children polyclinic (intervention group: 45, control group: 45). personal information form, shaken baby syndrome assessment survey will be used to collect data. simple randomization will be used to evaluate the intervention and control groups. in order to identify mothers in intervention groups, sealed-envelope randomization method will used. mothers and statistician group will be unaware of the evaluation. the researcher will not be blind because of the role he plays in the research. following the pretest, the intervention group will be trained to prevent shaken baby syndrome. expert opinion was obtained from 10 expert faculty members for the content of the training. after the training, the booklet prepared in line with expert opinions will be given to the mother in the intervention group. the booklet will remain with the mother. tele-consultancy will be given to the mother for 2 months after the pre-test. the control group will also be tested beforehand and will not be intervened afterwards. 2 months after the pre-test, a post-test will be applied to the control group and training will be given to prevent shaken baby syndrome. a training booklet will be given to the mothers in the control group after the final test. statistical analysis will be done using spss 23.0 and statistical significance will be set at p \<0.05. support will be received in the analysis phase of the statistical information unit of akdeniz university.

Eligibility criteria:
inclusion criteria: having a baby of 2-4 months, free from physical or mental disability exclusion criteria: unhealthy (mother or baby), any sbs education in the last 2 years

Keywords: awareness knowledge mothers nursing shaken baby syndrome
safety study of an antipsychotic, sertindole, to treat schizophrenia

Conditions: Schizophrenia

Summary: the purpose of this study is to permit the patients with schizophrenia who received sertindole during a previous randomised trial, study 99824, to continue with this treatment.

schizophrenia is a disabling and often chronic disorder that may require long-term treatment. this protocol is an extension study of a randomised study comparing the safety of sertindole versus risperidone. patients who were randomised to sertindole and who completed the previous study have the possibility to receive continued sertindole treatment in this open one-arm study. sertindole is generally well tolerated and is approved in the eu, but not yet marketed in france. the follow-up of the patients will be similar to that in the previous study and requires quarterly visits. patient management reflects routine clinical practice in accordance with the sertindole label. any severe safety issue is reported to the company.

Eligibility criteria:
inclusion criteria: * participation in the previous scop study, 99824 * still fulfils the eu spc requirements for sertindole exclusion criteria: * withdrawn before the end of the scop study, 99824 * become homeless * participation in another clinical trial at the same time * unlikely to comply with the clinical study protocol or is unsuitable for any reason

Keywords: schizophrenia sertindole safety study
the effect of intraoperative hypotension on postoperative cognitive functions in cesarean section operations

Conditions: Postoperative Cognitive Dysfunction

Summary: the aim of the study is to see whether the hypotension that develops during spinal anesthesia in cesarean section patients causes a decrease in the postoperative cognitive functions of the patient. if the results show a decrease in functions due to the effect of hypotension, it will be necessary to carry out aggressive prevention/treatment of hypotension in cesarean section patients.

a total of 150 female patients (75 in each group) between the ages of 18-40 who will undergo caesarean section with spinal anesthesia in the obstetric operating room of ankara bilkent city hospital in asa 2, 3rd categories will be included in the study. patients will be divided into two as hypotensive and non-hypotensive patients in spinal anesthesia with routine doses, and all patients will be given a mini mental test at preop and post op 1st hour. (hypotension, map(mean artery pressure)\<65 mmhg, or sap(systemic arterial pressure) \< 30% will be considered as an initial value.) patients who are hypotensive and need ephedrine will be included in the hypotensive group, and patients without hypotension will be included in the normotensive group. those with an initial mini mental test score below 24 will not be allowed to study. at the end of the research, the mental test scores of the two groups will be compared and the effect of hypotension will be evaluated. the patient's name-surname, age, protocol number, indication for cesarean section, method of regional anesthesia applied, sensory block level, bromage score, side effect follow-up, first ten minutes after the procedure, every two minutes, up to half an hour, and every fifteen minutes after thirty minutes, systolic artery pressure, diastolic artery pressure, average arterial pressure, pulse and ephedrine (if used) will be recorded. preoperative, postoperative first hour mini mental test score will be administered and recorded

Eligibility criteria:
inclusion criteria: * female patients between the ages of 18-40 in the asa2, 3rd categories who will undergo cesarean section with spinal anesthesia who agree to participate in the study exclusion criteria: * failure of the patient to accept * the necessity of an additional intervention to the cesarean section * change of routine practices on a patient-by-patient basis with the occurrence of complications in the surgical process * presence of additional diseases * emergency cases, cases using intraoperative sedation * those who do not speak the language * those who have an initial mini mental test score lower than 24

Keywords: cesarean section postoperative cognitive dysfunction hypotension
studying dna in tumor tissue samples from patients with localized or metastatic osteosarcoma

Conditions: Sarcoma

Summary: rationale: studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in dna and identify biomarkers related to cancer. purpose: this research study is looking at dna in tumor tissue samples from patients with localized or metastatic osteosarcoma.

objectives: * determine the genomic expression profile in tumor tissue samples from patients with localized or metastatic osteosarcoma using transcriptome sequencing. * identify activating and loss of function mutations and gene rearrangement in these tumor tissue samples using transcriptome sequencing. * identify candidate genes that are important in osteosarcoma and tumorigenesis using genome partition strategies for genomic dna sequencing. * identify which mutations are associated with outcome. * establish which mutations are also found in germ line dna that predispose the patient to osteosarcoma. outline: dna and rna from banked tumor tissue samples and dna from paired blood samples are analyzed in sequencing studies using next-generation sequencing technology. the sequencing data from these tumor samples are matched to the human refseq (for transcriptome sequencing) and normal human genome in the public databases and to the patient's germ line sequence to identify constitutional and somatic mutations. clinical information that is associated with each sample (i.e., age, tumor site, size, primary metastases, response to chemotherapy, surgical remission, follow-up time, and treatment protocol) is also collected, if available.

Eligibility criteria:
disease characteristics: * diagnosis of localized or metastatic osteosarcoma * banked snap-frozen tumor tissue samples and paired blood dna samples available patient characteristics: * not specified prior concurrent therapy: * not specified

Keywords: localized osteosarcoma metastatic osteosarcoma
the effects of nexium on the side effects associated with a colonoscopy prep

Conditions: Nausea; Vomiting; Abdominal Pain

Summary: the purpose of this study is to ascertain if the use of nexium for 7 days prior to taking a colon prep for a colonoscopy will decrease the side effects that are associated with the colon preparation

the high incidence for colon cancer make it an ideal target for screening. in the united staes there are approximately 100,00 new cases of colon cancer yearly. typically the progression from polyps to cancer requires years. this permits a screening procedure to identify polyps befoere they are cancerous. colon cleansing is required prior to colonoscopy. the gastrointestinal syptoms associted with colonic preps are common and oftn assoicated wwith upper gastrointestinal disorders including gerd, non-ulcer syspepsia, and gastric dysmotoility such as gastropareesis.

Eligibility criteria:
inclusion criteria: * subject 18 or older undergoing out-patient colonoscopy exclusion criteria: * pregnant females use of protein pump inhibitor within last 4 weeks use of prescription strength h-2 blocker within last 4 weeks use of over the counter strength h-2 blocker greater than 2x's a week hospitalized patients peg-el purgative contraindicated.

Keywords: colonoscopy prep
smartphone-administered app treatment for adults with body dysmorphic disorder

Conditions: Body Dysmorphic Disorders

Summary: the investigators are developing and testing a smartphone-based cognitive behavioral therapy (cbt) "app" for body dysmorphic disorder (bdd). the investigators hypothesize that app-based cbt for bdd will be feasible and acceptable to individuals with bdd, and will improve body image concerns and related outcomes.

the primary aims of this study are to develop and test the feasibility, acceptability, and preliminary efficacy of a smartphone-based cbt treatment for adults with bdd. this project aims to solve two healthcare problems: poor access to empirically-supportive treatment for bdd, and challenges of generalizing cbt skills outside therapy sessions. inadequate treatment access is due to limited professionals offering this specialized treatment, economic barriers, and shame preventing sufferers from seeking in-person care. mobile app-based cbt would solve this access gap by addressing each of these barriers. among those who obtain cbt, practicing skills outside of therapy is critical for treatment effectiveness, as bdd symptoms occur around-the-clock and can be most impairing at home. however, bdd patients struggle to use skills without therapists' in-person support. app-based cbt that provides on-hand skills coaching addresses this treatment generalization challenge. this study involves developing the app-based cbt for bdd treatment, and then investigating the initial feasibility, acceptability, and preliminary efficacy of the app-based treatment in an open pilot trial (n = 10), consisting of 12-weeks of active treatment plus a 6-month follow up period.

Eligibility criteria:
phase 1b (open pilot trial): inclusion criteria: * at least 18 years of age * outpatients * meets current diagnosis of primary dsm-5 bdd * has score on bdd-ybocs of ≥ 20 * currently living in the united states exclusion criteria: * psychotropic medication changes within 2 months prior to enrollment * participants taking psychotropic medication have to have been on a stable dose for at least 2 months prior to enrollment and not change medication during study period * participated in cbt for bdd ever during lifetime * current substance dependence * lifetime bipolar disorder or psychosis * acute, active suicidal ideation * current severe comorbid major depression, defined by a phq-9 total score ≥ 20 * personality disorder that could jeopardize treatment participation (e.g., borderline personality disorder with self-harm) * concurrent psychological treatment * do not own a supported mobile smart phone with a data plan (currently iphone 5s or more recent, running ios 9 or newer) * intellectual disability or other cognitive impairment that would interfere with ability to engage in cbt

Keywords: bdd
healthy lifestyle or pro-health obsession during the pandemic

Conditions: Adult; Global Health

Summary: citizens of many countries are in the high peak period of the outbreak of the covid-19 virus. people are currently struggling with the total cessation of certain aspects of normal life. the situation associated with the pandemic can lead to the development of many problems connected both with mental and physical health. the investigators, as psychologists, would like to better understand this difficult situation and identify mechanisms which can lead to health problems. therefore, group of researchers and practitioners created this study to investigate how people in general cope with this critical situation. the researchers would like to estimate the following variables which participants will evaluate before and during the pandemic period: levels of physical activity, attitudes towards one's body, attitudes towards eating, and psychological well-being. the investigators would like to involve experts and scientists from all around the world. through this research and by investigating how people cope with this critical situation the solutions for psychological care and interventions for global crisis situations like the covid-19 pandemic might be identified.


Eligibility criteria:
inclusion criteria: - age: min 18 years old exclusion criteria: - no

Keywords: covid-19 well-being physical activity nutrition body image
role of proteomics in diagnosing sarcoidosis

Conditions: Sarcoidosis

Summary: sarcoidosis is a multi-systemic disorder, meaning that it can involve any organ in the body and that its clinical presentation is highly variable. in 90% of all sarcoidosis cases the lungs are affected. it is difficult to give a concise definition of sarcoidosis due to the fact that its exact cause is still unknown. consequently, diagnosing the disease is also rather difficult. up till now, sarcoidosis is generally diagnosed by using general clinical methods to evaluate the status of the lung including a chest x-ray, lung biopsy and bronchoalveolar lavage (bal). however, some of these methods are considered to be rather invasive and, even more important, non-conclusive. therefore, the current study has been designed to evaluate the use of a new technique, called seldi-tof mass spectrophotometry, for the diagnosis of sarcoidosis. this technique enables the analysis of all enzymes present in the blood of sarcoidosis patients which may hopefully lead to creating a disease-specific protein-profile that may facilitate the recognition of sarcoidosis. moreover, these results will be compared with other currently used laboratory parameters.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of pulmonary sarcoidosis stage i-iv exclusion criteria: * non-smoking * no treatment for extra-pulmonary symptoms of sarcoidosis

Keywords: sarcoidosis protein profile cyp-450 tnf-alpha polymorphisms hla
association between response to treatment of c. diff colitis and anti-c.diff toxin antibody

Conditions: Clostridium Enterocolitis; Pseudomembranous Colitis; Antibiotic-Associated Colitis

Summary: the purpose of this study is three fold: 1)to collect serum from patients with documented clostridium difficile infection and test for the presence of antibody to c. difficile toxin at the start and at the end of therapy, and again if a relapse or recurrence occurs. 2)to collect stool samples for test of c. difficile toxin at similar time intervals. 3)to assay random serum samples from the va lab in order to determine the rate of antibody to c. difficile toxin in our patient population.

clostridium difficile is the leading cause of nosocomial diarrheal disease associated with antibiotic therapy. this is a debilitating condition with substantial morbidity and mortality that may be around 2-3%. current recommended therapy for this condition is metronidazole, given orally. our observations suggest that about 10-20% of patients fail to respond to initial therapy with metronidazole, and 20% relapse after treatment. the reason why some persons are cured whereas others relapse is, at present, unknown. there is a suggestion in the medical literature that recurrent infection is associated with the failure to generate antibody to c. difficile toxin. it is also possible that those patients who become infected lack antibody, whereas others in the population tend to have such antibody. the investigators propose to study our patients at vamc houston in order to relate occurrence and/or the failure to respond to therapy or the appearance of recurrent disease to the presence of anti-toxin antibody. the investigators also propose to study sera obtained at random from vamc patients in order to determine the prevalence of antibody in our patient population.

Eligibility criteria:
inclusion criteria: * all patients at the houston va with documented c. difficile infection exclusion criteria: * none

Keywords: clostridium difficile
emotion endophenotypes in schizophrenia

Conditions: Schizophrenia

Summary: schizophrenia is an invalidating psychiatric illness with a strong genetic component characterized by abnormal processing of emotional information. this alteration in emotion processing has been described in acute as well as in remission phases of the illness. it has also been found in healthy relatives of patients with schizophrenia and in subjects at high risk of psychosis. thus, alterations in emotional information processing are not only linked to the prognosis but can also be considered as a marker of vulnerability of schizophrenia. in addition, schizophrenia patients differ from healthy controls in neural activity in brain regions implicated in emotions processing. however, interpretation of findings in patients is limited by confounding factors, such as antipsychotic treatments or alterations due to the course of illness. also, there is no data concerning genetic factors (polymorphisms or gene expression) underlying these patterns of cerebral activation in emotion information processing. so, the main objective of this study is to compare the cerebral activity of schizophrenia patients to that of healthy siblings and healthy controls in an emotional processing task.


Eligibility criteria:
inclusion criteria: * male or female participant, right-handed, aged from 18 to 45 years old * haven given their written consent * dsm-5 (diagnostic and statistical manual of mental disorders version 5) diagnosis of schizophrenia * remitted phase (criteria of andreasen) * stable doses of antipsychotics during the last 6 weeks * no severe somatic illness * normal clinical exam * inscription to the social security exclusion criteria: * women in genitally active period without contraception * women pregnant or breast feeding * participants presenting a severe somatic /neurologic condition * present/history in the last year of alcohol or drug abuse * participating in another clinical study or still in period of exclusion of a previous clinical trial * contraindication to an mri test (metallic foreign body, pacemaker, heart valve, chirurgical clip, claustrophobia...)
a pilot study of crizotinib in patients with c-met positive gastric adenocarcinoma as a third-line chemotherapy

Conditions: c-MET Positive Gastric Cancer

Summary: this is a pilot study of crizotinib in patients with c-met positive gastric adenocarcinoma.


Eligibility criteria:
inclusion criteria: 1. provision of fully informed consent prior to any study specific procedures. 2. patients must be ≥20 years of age. 3. advanced gastric adenocarcinoma (including gej) that has progressed during or after second line therapy. 4. c-met positive gastric cancer 5. ecog ps 0-2 6. at least one measurable disease 7. proper organ function exclusion criteria: 1. severe co-morbid illness and/or active infections 2. pregnant or lactating women 3. history of documented congestive heart failure; angina pectoris requiring medication; evidence of tranasmural myocardial infarction on ecg; poorly controlled hypertension; clinically significant valvular heart disease; or high risk of uncontrollable arrhythmia 4. active cns metastases not controllable with radiotherapy or corticosteroids (however, cns metastases (except for leptomeningeal seeding) are allowed if controlled by gamma knife surgery or surgery or radiotherapy or steroid) 5. known history of hypersensitivity to study drugs

Keywords: met poisitivity is defined as at least half of tumor cells show weak, moderate or high staining