Kornimate/medical-research-clean huggingface dataset:
rheumatoid arthritis dmard intervention and utilizationstudy

Conditions: Rheumatoid Arthritis

Summary: to systematically collect and document use patterns, effectiveness and safety of dmard treatments currently used in the management of rheumatoid arthritis. the primary purpose of this study is to estimate the incidence of serious adverse experiences and adverse experiences of interest in patients with rheumatoid arthritis (ra) treated with enbrel®.


Eligibility criteria:
inclusion criteria: * fulfillment of the 1987 american rheumatism association criteria for ra * currently requiring the addition of enbrel® therapy (to be taken alone or in addition to their current dmard therapy) exclusion criteria: * currently or previously enrolled in radius 1 * currently enrolled in a clinical trial where treatments or patient visits are imposed by a protocol * active infections * known allergy to enbrel® or any of its components * current treatment with enbrel® * patients who have previously been demonstrated to be intolerant of or refractory to enbrel® therapy * nursing or pregnant women

Keywords: rheumatoid arthritis dmard
autologous bronchial basal cell transplantation for treatment of copd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: chronic obstructive pulmonary disease (copd) is usually characterized by long-term poor airflow, resulting in chronic pulmonary heart disease, chronic respiratory failure or even death. for copd patients, pulmonary bronchus structures are damaged and cannot be repaired by recent clinical methods so far. this study intends to carry out a single-centered and non-randomized phase i/ii clinical trial with concurrent controls to investigate whether bronchial basal cells can regenerate damaged lung tissue. during the treatment, bronchial basal cells will be isolated from patients' own bronchi and expanded in vitro. after careful characterization, expanded cells will be transplanted autologously into the lesion by fiberoptic bronchoscopy. the safety and efficacy of the treatment will be monitored by measuring the key clinical indicators.


Eligibility criteria:
inclusion criteria: * aged between 40 to 75; * diagnosed with copd according the guideline (a. with symptoms of productive cough, sputum production or shortness of breath; b. with poor airflow as indicated by fev1\<70% predicted value and fev1/fvc \< 0.7 in pulmonary function test; c. with exclusion of other pulmonary disease by ct or blood examination.); * current smoker or ex-smoker with a history of no less than 10 years or 10 packs/year; * tolerant to bronchofiberscope; * written informed consent signed. exclusion criteria: * pregnant or lactating women; * patients positive for syphilis, hiv; * patients with malignant tumor; * patients with serious significant pulmonary infection and need anti-infection treatment; * patients with serious heart disease(nyha class ⅲ-ⅳ); * patients with a history of abusing alcohol and illicit drug; * patients participated in other clinical trials in the past 3 months; * patients assessed as inappropriate to participate in this clinical trial by investigator.
intraoperative imaging device based on endogenous optical properties to evaluate bowel oxygenation in colorectal resections

Conditions: Left-sided Colorectal Resection : Diverticular Diseases; Left-sided Colorectal Resection : Colonic Neoplasms; Left-sided Colorectal Resection : Rectal Neoplasms

Summary: the objective of the study is to assess the safety and technical feasibility of a new imaging system, used during colorectal resection surgery, named trident in version 1.0, which could be used by the surgeon during colorectal procedures to obtain information on intestinal tissue oxygenation.

this is a prospective, non-randomized, single center, feasibility trial. all consecutive patients that fulfil the inclusion/exclusion criteria will be informed about the possibility to be included in the present clinical investigation. only subjects that have signed the study informed consent will be included in the study. the trident system v1.0 will be used only during approximately 2 to 5 minutes during a precise surgical step, i.e., just before the final resection of the surgical specimen. patients will be prospectively followed at 30 days post-surgery. data will be collected prospectively from the medical records.

Eligibility criteria:
inclusion criteria: * patient scheduled for a left-sided colorectal resection, irrespective of the surgical approach (open surgery, laparoscopic surgery,) because of: * colon cancer or * sigmoid diverticular disease or * rectal cancer * all genders * age \> 18 years old * ability to understand the information related to the study protocol exclusion criteria: * pregnancy or breastfeeding * contraindications to anaesthesia * inability to provide a written informed consent * inclusion in a different ongoing clinical trial * emergency procedure * abdomino-perineal resection * hartmann procedure * patient is part of vulnerable population (e.g., prisoners, mentally disabled)

Keywords: colorectal surgery trident system tissue oxygenation
oral probiotics on radiation enteritis stage ⅱ induced by pelvic concurrent chemoradiotherapy

Conditions: Pelvic Cancer, Enteritis, Probiotics,Chemoradiotherapy

Summary: effect of probiotics on raditon enteritis in pelvic tumor patients receiving radiotherapy.

radiation-induced enteritis is an common and severe side effect of the patients undergoing pelvic radiotherapy. it can lead to dose-limiting and debilitating treatment effect. there is no guideline on an acknowledged intervention that significantly reduces its severity. in previous study, we have abserved that a probiotic combination significantly enhances the immune response of patients and reduces the severity of oral mucositis through modification of gut microbiota. in this stuyd we plan to designe a randomized trial of probiotics probiotics in patients with pelvic carcinoma.the aim of this study is to determine if regulating intestinal tract flora will reduce the severity of radiation-induced mucositis in patients receiving pelvic radiotherapy. the effect of this intervention on a patient's general well-being was also investigated. the primary end-point of the study was the incidence of grade 3 enteritis. in 2021, 40 patients are estimated to be recruited into the study in jiangxi cancer hospitals, china. 20 patients were randomized to receive probiotics or placebo during chemoradiotherapy respectively.

Eligibility criteria:
inclusion criteria: * karnofsky score ≥80 pelvic tumor patients receiving chemoradiotherapy in our cancer center exclusion criteria: * any immune system disease under high risk to antimicrobial agents such as diabetes,infection disease or drug allergy to probiotics
picco guided therapy in liver cirrhosis

Conditions: Liver Cirrhosis

Summary: prospective comparison of standard therapy in liver cirrhosis versus standard therapy plus intensified hemodynamic monitoring using the picco system.

patients presenting with advanced liver cirrhosis will receive either standard treatment or standard treatment plus hemodynamic monitoring with the picco device. fluids and vasoacitve drugs will be administered according to the measurements over a period of 5 days.

Eligibility criteria:
inclusion criteria: * liver cirrhosis child-pugh-score \> 7 * ascites \> 500 ml exclusion criteria: * coronary heart disease * apoplexia \< 6 months ago * vasculitis * thrombosis * arterial occlusive disease \> stadium ii

Keywords: liver cirrhosis hemodynamics fluid balance
triage of abdominal pain in the emergency department

Conditions: Abdominal Pain

Summary: the investigators aim to evaluate in a retrospective study the performance of the swiss emergency triage scale to identify at the door of the emergency department patients requiring emergent intervention.

all patients are triaged at the door of our emergency department using the swiss emergency triage scale. patients with abdominal pain may be triaged in two different emergency levels (level 2: medical evaluation within 20 minutes, level 3: medical evaluation within 2 hours). these levels are determined using a set of specific criteria. the aim of this study is to evaluate the validity of these specific criteria in order to identify promptly patients with abdominal pain the will require an emergent intervention during their stay in the emergency department.

Eligibility criteria:
inclusion criteria: * \>= 16 y * abdominal pain as the main complaint exclusion criteria: * none
prevention of incontinence-associated dermatitis and maintenance of local skin microclimate：a multicenter study

Conditions: Incontinence-associated Dermatitis

Summary: to explore the feasibility of jefcare sterile medical sheets in preventing incontinence-associated dermatitis and maintaining a stable local skin microclimate in adult patients in the intensive care unit.

jefcare sterile medical sheet is an incontinence care product designed by researchers following the expert consensus on the clinical application of disposable absorbent care products for adults with incontinence. the product has good laboratory test indicators and has the potential to prevent incontinence-associated dermatitis and maintain the stability of the local skin microclimate. still, there is a lack of high-quality clinical studies.

Eligibility criteria:
inclusion criteria: 1. intensive care unit incontinent patients (incontinence time ≥2 days) 2. age ≥18 years 3. patients at high risk of iad (perineal assessment tool ≥ 7) 4. voluntarily participate in the study and sign an informed consent form. if the subject is unable to read and sign the informed consent form due to incapacitation or other reasons, their guardian is required to represent the informed process and sign the informed consent form. if the subject is unable to read the informed consent form (e.g., illiterate subjects), a witness will be required to witness the informed process and sign the informed consent form. exclusion criteria: 1. patients who have developed iad 2. expected subsequent stay in the intensive care unit \<5 days 3. use of nappies, pull-ups, incontinence pads, etc. 4. simple urinary incontinence with indwelling catheterization, external urinary bag without leakage; simple fecal incontinence with built-in drainage device, external ostomy bag, ob tampon without leakage; double incontinence with indwelling catheterization, external urinary bag, built-in drainage device, external ostomy bag, ob tampon without leakage. 5. the iad may affect the skin area within the scope of the disease that affects the iad judgment. 6. the iad may affect the skin area within the scope of the skin breaks, infection 7. patients who are not suitable for turning and cannot tolerate the side-lying position. 8. patients with known allergies or keloid scarring 9. women who are known to be pregnant or breastfeeding or who are planning to have a baby during the study period. 10. patients who have participated in a clinical trial of another drug or medical device within 3 months. 11. patients who, in the opinion of the investigator, are not suitable for participation in this clinical trial.

Keywords: incontinence-associated dermatitis microclimate jefcare sterile medical sheets
problem management plus for entrepreneurs

Conditions: Well-being; Psychological Capital; Anxiety; Depression

Summary: conflict and unrest over three decades has resulted in significant economic decline in khyber pakhtunkhwa (kp) and federally administered tribal areas (fata) of pakistan and these now rank among the poorest regions in the country. the 2009-10 insurgency and subsequent security operations affected both regions and displaced an estimated 2 million people. the severe damage to infrastructure and livelihoods negatively impacted the social and economic fabric of the entire region. as peace has returned to the area, the economic revitalization of kp and fata (erkf) project, established in 2012 and supported by the world bank, is working for the rehabilitation of small and medium enterprises (smes), with the aim of creation and restoration of jobs. this support is in the form of grants given to individuals who use the funds to establish and run a business in their locality. epidemiological studies from the area have shown high rates of common mental disorder (eg., depression, anxiety) in the general population (husain et al, 2006, khan et al 2016). such conditions have a serious impact on the well-being, functioning and productivity of affected individuals (world health organization, 2000). for example, in the usa, depressive disorders have been estimated to cost the economy over us$210 billion per annum, largely due to reduced productivity (greenberg et al, 2015). the economic rehabilitation of a population exposed to a humanitarian crisis, and therefore at greater risk of depression, must include interventions to reduce mental morbidity so the individuals are able to function better and potentially improve their long-term productivity. the human development research foundation, in collaboration with the world bank, has adapted a 5-session group intervention from who problem management plus program, tailored to the needs of small and medium enterprise owners affected by the prolonged conflict in kp and fata areas of pakistan. this intervention (problem management plus adapted for entrepreneurs) is based on established cognitive behavioral strategies previously tested in pakistan (rahman et al, 2016). the goal of the intervention is to improve psychological capital,reduce psychosocial distress leading to, increased productivity in the long-term. the intervention will be evaluated using a two arm, single blind randomized controlled trial.


Eligibility criteria:
inclusion criteria: * all small and medium entrepreneurs, leading smes and family businesses in situations of fragility encountered in kp/fata, pakistan, who received a cash transfer for rehabilitation of their businesses by economic revitalization of khyber pakhtunkhwa and fata (erkf), pakistan. exclusion criteria: -

Keywords: well-being entrepreneurs conflict affected settings psychosocial intervention psychological capital
16-week efficacy and 2-year safety, tolerability and efficacy of secukinumab in participants with active psoriatic arthritis

Conditions: Arthritis, Psoriatic

Summary: the purpose of this study was to provide 16-week efficacy, safety and tolerability data versus placebo to support the use of secukinumab 150 mg by subcutaneous (s.c.) self-administration with or without a loading regimen and maintenance dosing using pre-filled syringe (pfs) and to assess efficacy, safety and tolerability up to 2 years in subjects with active psa despite current or previous nsaid or dmard therapy


Eligibility criteria:
inclusion criteria: * diagnosis of psoriatic arthritis (psa) classified by classification criteria for psoriatic arthritis (caspar) criteria. * rheumatoid factor and anti-cyclic citrullinated peptide (ccp) antibodies negative. * diagnosis of active plaque psoriasis or nail changes consistent with psoriasis. * inadequate control of symptoms with nsaid. * other protocol-defined inclusion criteria do apply. exclusion criteria: * chest x-ray or chest magnetic resonance imaging (mri) with evidence of ongoing infectious or malignant process. * subjects taking high potency opioid analgesics. * previous exposure to secukinumab or other biologic drug directly targeting interleukin-17 (il-17) or il-17 receptor. * ongoing use of prohibited psoriasis treatments / medications. * subjects who have ever received biologic immunomodulating agents except for those targeting tnfα. * previous treatment with any cell-depleting therapies.

Keywords: ain457 psoriatic arthritis chronic inflammatory disease loading regimen secukinumab self-injection
e-health program to prevent exacerbations in the cystic fibrosis population

Conditions: Cystic Fibrosis

Summary: the goal of this clinical trial is to analyse the impact of a telematic assessment and monitoring protocol in people with cystic fibrosis, in order to identify exacerbations early, thus preventing loss of lung function and maintaining quality of life. participants will be assigned to one of 3 study groups: control group (cg-1): will receive their usual physiotherapy treatment; treatment group (tg-2): will receive their usual physiotherapy treatment, plus explanation of the use of the monitoring equipment; treatment and follow-up group (tgf-3): will receive their usual physiotherapy treatment, plus explanation of the use of the monitoring equipment, plus telematic control of exacerbations with feedback from the physiotherapist.


Eligibility criteria:
inclusion criteria: * diagnosed cystic fibrosis * family access to an internet-enabled device * camera and microphone * absence of exacerbations in the last 30 days exclusion criteria: * patients with lung transplant or on the waiting list for lung transplantation * previous eye surgery (3 months) * hemothorax * active infection or inflammatory process * tumors * cognitive problems that make it impossible for them to use telematic devices.

Keywords: e-health physiotherapy cystic fibrosis exacerbation quality of life
factors associated with physical inactivity among adolescents

Conditions: Physical Inactivity; Obesity; Overweight

Summary: despite the acknowledgment that physical activity is important for health, there are still few population-based or school-based studies that uses the current physical activity guidelines for adolescents. physical inactivity was defined a less than 300 min/w of moderate to vigorous-intensity physical activity practice. previous research has shown very high prevalence rates of physically inactive adolescents and a strong association with demographic, socioeconomic and biological factors. based on this information, the investigators are elaborating a systematic review of literature to obtain and provide more accurate information in this context.

the objectives of this study were to (i) review extant literature on the prevalence of physical inactivity (pi) in adolescents of both sex (10-18 years old); (ii) compare its prevalence between developed and developing countries. the search was carried out using online databases (biomed central, cinahl, embase, eric, medline, psycinfo, scopus, sportdiscus), references cited by retrieved articles and by contact with the authors, considering articles published from the establishment of the databanks until april 29th, 2010.

Eligibility criteria:
inclusion criteria: * cross-sectional studies. * original studies showed that physical inactivity is evaluated through a questionnaire. * studies which ranked 300\> inactivity min/wk. exclusion criteria: * studies did not assess physical inactivity through a questionnaire. * studies in which the participants were only overweight/obese, diabetics or suffering from another disease.

Keywords: physical activity epidemiology questionnaire cross-sectional study
pulmonary hypertension association registry

Conditions: Pulmonary Arterial Hypertension; Chronic Thromboembolic Pulmonary Hypertension; Pulmonary Hypertension

Summary: the pha registry (phar) is a national study about people who have pulmonary arterial hypertension (pah) and chronic thromboembolic pulmonary hypertension (cteph). phar collects information from people with pah and cteph who are cared for in participating pha-accredited pulmonary hypertension care centers throughout the u.s. phar will determine how people with pah and cteph are evaluated, tested, and treated, and will observe how well these participants do. the goal is to see if people with ph are treated according to recommended guidelines, and to see if there are certain factors that can lead to better or worse outcomes. phar will include information about people with pah and cteph in the u.s. who are seen at participating pha-accredited ph care centers. phar contains data about patient care and outcomes. specifically, data in the phar includes information on diagnosis; clinical status; socioeconomic status; diagnosis test results; body size; treatment information; interest in participating in clinical trials; family health and social history; and information about smoking, alcohol, or drug use. participants are followed over time, and provide updates such as changes in therapy, how often participants need to go to the hospital, and survival. such information may help healthcare providers provide better care.


Eligibility criteria:
inclusion criteria: * all age groups * written informed consent * pulmonary arterial hypertension (pah), chronic thromboembolic pulmonary hypertension (cteph), or pediatric ph due to developmental lung disease * within 6 months of first outpatient visit at a ph care center exclusion criteria: * diagnosis of wsph group 2 pulmonary hypertension * diagnosis of wsph group 3 pulmonary hypertension, except ph due to developmental lung disease * diagnosis of wsph group 5 pulmonary hypertension
effectiveness of saline water and lidocaine injections for the treatment of intractable plantar keratoma

Conditions: Intractable Plantar Keratoma

Summary: an intractable plantar keratoma (ipk) is a conical thickening of the epidermis' stratum corneum and a common cause of foot pain which can have a significant, detrimental impact on the mobility, quality of life and independence of individuals. conservative treatments are currently offered to patients with ipk, but they are unsatisfactory since they do not offer a sufficient or permanent reduction of symptoms. the purpose of this study was the evaluation of the feasibility, safety and effectiveness of innovative treatments for intractable plantar keratoma (ipk)


Eligibility criteria:
inclusion criteria: • having a painful ipk for at least 3 months exclusion criteria: * ongoing pregnancy or breastfeeding * severe cardiovascular or neurological disease * immunosuppressed status * presence of a plantar ulcer * allergy to lidocaine * history of keloid or hypertrophic scar * simultaneous painful plantar syndrome unrelated to the presence of an ipk
implementation and evaluation of hospital-to-home transitional care intervention in patients with chronic heart failure

Conditions: Chronic Heart Failure

Summary: this study lasted for a total of three months. the purpose is to build a hospital-family transitional nursing intervention program for patients with chronic heart failure, and to explore the effectiveness of the program on the self-management of patients with chronic heart failure, in order to provide certain empirical research for the clinical intervention of transitional nursing for patients with chronic heart failure. if you have any questions or difficulties, you can withdraw from this study at any time, which will not affect your treatment and nursing. the purpose of this study is to improve your self-care level and prevent your re-admission. it will not harm your physical and mental health and will not have a negative impact on the relationship between patients and nursing. you participate in this study and the personal data in the study is confidential, and any public report on the results of this study will not disclose your personal identity.


Eligibility criteria:
inclusion criteria: * it meets the diagnostic criteria of the new york heart association (nyha) for chf, and the heart function level is ii to iii; * age ≥18 years old; * the condition is stable and meets the standard of being discharged from the hospital; * clear consciousness, no communication barriers, able to understand and fill in the questionnaire correctly; * informed consent and voluntary participation in this study. exclusion criteria: * patients with hepato-renal disfunction, sequelae of stroke, dementia; * patients with a history of mental disorders or already having mental disorders, critically ill patients.