Kornimate/medical-research-clean huggingface dataset:
a long-term study of ak102 in patients with hypercholesterolemia

Conditions: Hypercholesterolemia

Summary: this is a phase ii, open-label, non-controlled, extended study. the main objective of this study is to evaluate the long-term efficacy and safety of ak102 in combination with basic lipid-lowering therapy in patients with hypercholesterolemia. subjects who have participated in the ak102 studies and have completed the last visit,and who, in the opinion of the investigator, are likely to benefit from continued treatment will be enrolled in this study.


Eligibility criteria:
inclusion criteria: 1. signed informed consent. 2. body weight ≥ 40 kg for both men and women. 3. participated in the ak102-202 study, and completed the ak102-202 study last visit. exclusion criteria: 1. poor compliance in ak102-202 study per investigator's judgement. 2. ae that led to permanent discontinuation of ak102 occurred during the ak102-202 study period. 3. prior use of pcsk9 inhibitors other than ak102.
quantitative ct imaging parameters for assessing hepatic steatosis in chb

Conditions: Chronic Hepatitis B; Steatosis of Liver; Fibrosis and Cirrhosis of Liver

Summary: this study aims to evaluate diagnostic performance of ct attenuation parameters acquired using deep learning algorithm in assessing hepatic steatosis and fibrosis.


Eligibility criteria:
inclusion criteria: * chronic hepatitis b * no chronic liver disease other than chronic hepatitis b * body mass index \&gt;= 23 exclusion criteria: * pregnant women * unable to perform mri examinations due to claustrophobia or metallic foreign body * suspicious hepatic malignancy on previous imaging studies * history of local treatment for hepatic lesions * history of surgery or catheter insertion of liver or spleen
the effectiveness of doin (conduction exercise) of the pelvic joint for hld with radiating leg pain

Conditions: Intervertebral Disc Displacement; Sciatica; Sciatic Radiculopathy

Summary: a prospective pilot study will be conducted to investigate the effectiveness and safety in herniated lumbar disc (hld) patients receiving integrative korean medicine treatment including doin (conduction exercise) at a korean medicine hospital through assessment of pain, functional disability, and quality of life.

a prospective single-center observational pilot study will be conducted to investigate the effectiveness and safety in herniated lumbar disc (hld) patients with radiating leg pain receiving integrative korean medicine treatment including doin (conduction exercise) of the pelvic joint at daejeon jaseng hospital of korean medicine through assessment of pain, functional disability, quality of life, satisfaction, and safety. the study is expected to be performed over a period of 6 months, during the former 3 months of the study period of which the integrative korean medicine treatment group will be recruited, and after a wash-out period of 2 weeks, during the latter 3 months of the study period of which the doin with integrative korean medicine will be recruited separately.

Eligibility criteria:
inclusion criteria: * inpatients with radiating leg pain distal to the gluteal fold with or without low back pain (lbp) * patients with onset of radiating leg pain occurrence within the last six months, and current pain intensity of numeric rating scale (nrs) ≥5 * patients with disc protrusion or extrusion at the neural segment level with significant correlations with the radiating leg pain symptoms as identified on l-spine magnetic resonance imaging (mri) * patients with plans of receiving korean medicine treatment for herniated lumbar disc (hld) through hospitalized care * patients who give voluntary written informed consent to study participation exclusion criteria: * patients with other systemic diseases that may interfere with treatment effect or outcome interpretation * surgery and surgical procedure in the last three weeks in areas of clinical relevance as a result of hld * patients with soft tissue pathologies or pathologies of non-spinal origin that may cause lbp or radiating leg pain (e.g. spinal tumor, rheumatoid arthritis) * patients for whom acupuncture treatment may be inappropriate or unsafe (e.g. hemorrhagic diseases, blood clotting disorders, history of anti-coagulation medicine intake, serious diabetes with risk of infection, severe cardiovascular diseases, or other conditions deemed unsuitable for acupuncture treatment) * pregnant patients or patients planning pregnancy * patients with serious psychological disorders * participating in other clinical studies other than observational studies * patients unable to fill out study participation consent form * subjects deemed unsuitable for study participation as assessed by the researchers

Keywords: complementary therapies exercise acupuncture
pregnancy in osteogenesis imperfecta (oi) registry

Conditions: Osteogenesis Imperfecta; Brittle Bone Disorders

Summary: the purpose of this study is to learn about pregnancy outcomes in osteogenesis imperfecta (oi). patients enrolled in the brittle bone disorders (bbd) contact registry (cr) will be invited via email to participate in this study.

population: the rdcrn bbd contact registry helps researchers identify and recruit patients who are eligible for participation in future research studies. people eligible for enrollment in the rdcrn bbd contact registry include patients and parents of patients with brittle bone disorders. all patients with bbd from the united states and around the world are encouraged to join. survey administration: the investigators will administer a review of pregnancy outcomes survey and delineate the outcomes in pregnancies complicated by varying forms of oi. patients will be sent an email invitation describing the study. if the participant wants to participate and is eligible, she will follow the survey link in the email message, which directs her to an irb-approved online consent form. a unique survey link will be generated for each participant and included in the survey invitation, which is a customized email message. this link will allow the investigators to determine who completed the survey. the investigators will send repeat email invitations every two months (total of 3 invitations) to those invitees who have not yet participated. the investigators will allow approximately 6 months for enrollment and survey completion and expect that the study will close soon thereafter. data: the survey data will be collected and stored at the rare diseases clinical research network's data management and coordinating center (dmcc) at the university of south florida. all data collected will be sent to the database of genotypes and phenotypes (dbgap) to be stored indefinitely.

Eligibility criteria:
inclusion criteria: * female with oi who has delivered an infant of at least 24 weeks' gestation * participant in the bbd contact registry exclusion criteria: * inability to provide informed consent and complete survey * males * women with oi who have not delivered children and gestations associated with higher order multiples

Keywords: brittle bone osteogenesis imperfecta bbd oi congenital abnormalities congenital bone disorder lobstein syndrome
medication adherence intervention in chronic recurrent multifocal osteomyelitis (crmo)

Conditions: Chronic Recurrent Multifocal Osteomyelitis

Summary: this project aims to quantify and evaluate rates of non-adherence and barriers to medication adherence in pediatric patients with crmo followed at seattle children's hospital's robust crmo program, which is the only clinical program in the washington, wyoming, alaska, montana, idaho (wwami) region. this will be a stepped-wedge cluster-randomized trial, in which participants will be randomly assigned to one of two groups -- one which receives educational materials at the end of their first clinic visit, and the other which receives educational materials at the end of their second clinic visit. all participants will be given baseline surveys at the start of their first clinic visit, as well as follow-up surveys at the start of their second and third clinic visits. these surveys aim to evaluate rates of non-adherence and qualitative barriers to adherence, as well as efficacy of educational interventions in improving adherence rates.


Eligibility criteria:
inclusion criteria: * diagnosis of crmo * receives clinical care at seattle children's hospital * on one or more scheduled prescription medications exclusion criteria: -
community health workers and teleaudiology as a culturally-relevant approach to improving access to hearing health care

Conditions: Hearing Loss

Summary: the purpose of this study is to test the feasibility of a teleaudiology intervention with assistance from community health workers to improve access to hearing health care.


Eligibility criteria:
inclusion criteria: * bilateral hearing loss within the fitting range of study hearing aids exclusion criteria: * medically unqualified to receive hearing aids * current hearing aid user * cognitively impaired
collecting information about treatment results for patients with cushing's syndrome

Conditions: Cushing's Disease; Cushing Syndrome; Cushing Disease

Summary: the purpose of this study is to follow participants with cushing's syndrome during the course of their routine care and to form a data registry to study long term participant outcomes.


Eligibility criteria:
inclusion criteria: * age 14 or older * active or treated overt cushing's (due to pituitary, ectopic, or adrenal tumor), mild adrenal cushing's syndrome (macs), or a silent corticotroph tumor * the diagnosis of cs or macs will be made by the pi, based on the below endocrine society guidelines, the patient's clinical presentation, and the pi's judgment. * diagnostic criteria for acth-dependent cushing's are according to the endocrine society and european society of endocrinology guidelines and include: elevated 24-hour urinary free cortisol (ufc), normal or elevated plasma acth, elevated midnight salivary cortisol levels, or classic dexamethasone suppression testing for cd (morning cortisol \> 5 ug/dl after 1 mg overnight of classic 2-day low dose test) and a pituitary lesion on mri. if patient does not have any of these results, pathology of acth tumor may confirm presence of disease. * diagnostic criterion for macs is according to the european society of endocrinology guidelines: classic dexamethasone suppression testing for cd (morning cortisol \>1.8 µg/dl after 1 mg overnight). * for pituitary cushing's patients, if the patient demonstrates non-classic testing or no pituitary lesion is seen on mri then petrosal sinus sampling or positive surgical pathology will be used to confirm pituitary source of cushing's. clinical or biochemical remission after surgery will also confirm pituitary source. * ectopic cushing's will be confirmed by petrosal sinus sampling and appropriate imaging tests, or positive surgical pathology. * adrenal cushing's will be confirmed by a suppressed plasma acth value and identification of an adrenal lesion on ct or mri, or positive surgical pathology. * silent corticotroph tumors will be defined by surgical pathology demonstrating positivity for acth, in the absence of clinical and biochemical features of cushing's syndrome. * in lieu of mri, surgical, or laboratory reports, physician's assessment note including mention of results will also be used as source for eligibility purposes. exclusion criteria: * patients with a diagnosis of iatrogenic cushing's.

Keywords: cushing syndrome cushing's disease cushing disease 17-592 memorial sloan kettering cancer center
effects of intensive statin treatment on left ventricular function

Conditions: Acute Anterior Myocardial Infarction

Summary: first acute anterior myocardial infarction in patients with primary pci preoperative and postoperative 30 days intensive dose atorvastatin statin therapy compared with conventional -dose therapy , patients can improve left ventricular function , reduce major adverse cardiovascular events .


Eligibility criteria:
inclusion criteria: 1. ≥ 18 years of age 2. the first time clinical diagnosis of acute anterior myocardial infarction , the time of onset ≤ 12 hours ,intends underwent emergency pci 3. informed consent exclusion criteria: 1. taking , or the need for long-term use of statins is greater than the initial dose 2. treated with pci again within a mouth 3. active liver disease or liver dysfunction 4. the diagnosis of myopathy 5. severe renal insufficiency ( serum creatinine \> 178umol / l ) 6. statin drug allergy or had a serious adverse reaction 7. severe aortic stenosis or mitral stenosis , hypertrophic obstructive cardiomyopathy , pericardial disease 8. pregnancy 9. malignancy or any other end-stage diseases result in a life expectancy of \< 6 months 10. be participating in other clinical studies 11. not suitable for inclusion of the other cases 12. not treated with pci

Keywords: acute anterior myocardial infarction percutaneous coronary stent implantation intensive statin therapy left ventricular function
efficacy of a home-use photobiomodulation device for the treatment of patients with knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: osteoarthritis is a degenerative disease affecting joint cartilage and its surrounding tissue. it is the leading cause of disability in the elderly. photobiomodulation (pbm), has been used widely for alleviation of pain, reduction of inflammation, and acceleration of wound healing, and particularly to treat knee osteoarthritis (koa). the purpose of the current study is to determine if b-cure laser treatments, applied at home, by the patient or personal caregiver in a real-life situation, can reduce pain and improve functionality in patients with koa.

eligible patients with knee osteoarthritis will receive a b-cure laser device for self-application at home in addition to standard care. patients will be invited to the clinic for 3 visits: baseline, 1, and 2 months. evaluations at the visits will include physical examination, knee range of motion, time up\&go test, and patient reported outcomes including subjective pain level by visual analogue scale (vas), functional and quality of life questionnaires. the study hypothesis is that b-cure laser treatments, applied, at home, by the patient, can ameliorate koa related inflammation thereby reducing pain and improving functionality in these patients.

Eligibility criteria:
inclusion criteria: 1. diagnoses of knee osteoarthritis by american college of rheumatology (acr) 2. kellgren \& lawrence classification 2-3 3. knee pain on movement 40 to 90 mm visual analog scale 4. knee pain and related functional reduction for the last ≥ 3 months 5. agrees not to use nsaids throughout the experiment exclusion criteria: 1. pregnant or nursing, or with the ability to become pregnant and not using an accepted form of birth control 2. other causes of knee-related pain (e.g. hip oa, arterial insufficiency, radiculopathy etc) have been ruled out by physical examinations. 3. knee surgery for koa 4. intra-articular steroid injection and/or oral steroid treatment within the last six months 5. rheumatoid arthritis 6. active malignancy 7. uncontrolled diabetes mellitus 8. neurological conditions: sciatica, neuropathy, multiple sclerosis 9. other chronic pain conditions that may affect results: fibromyalgia, back pain, hip pain 10. has any photobiomodulation (low level laser) device at home or has previously used photobiomodulation for knee pain 11. has known dermatological sensitivity to light 12. enrolled in any other clinical trial within the last 6 weeks or enrollment in another clinical trial during participation in this trial. -

Keywords: photobiomodulation low-level laser therapy
assessment of the impact of oral intervention with cetylpyridinium chloride to decrease sars-cov-2 viral load in patients with covid-19

Conditions: COVID-19; SARS-CoV-2 Infection

Summary: pilot, randomized and controlled clinical trial for the evaluation of the decrease in the viral load of sars-cov-2 in the oropharynx in patients with covid-19 through the use of mouthwash containing cetylpyridinium chloride (cpc) (0.07%) in mouthwash.

the objective of the clinical trial is to determine the short-term efficacy of cetylpyridinium chloride (cpc) mouthwashes to assess changes in the threshold cycle value of the analysis of the sars-cov-2 oropharyngeal saliva sample, in patients diagnosed with covid-19 and with symptomatology compatible with the disease. a randomized double-blind pilot clinical trial (evaluator and patients) will be developed in patients with a diagnosis of covid-19 and symptoms of the disease. the experimental group will perform a single rinse with a mouthwash containing cetylpyridinium chloride (cpc) while the placebo group will perform the same rinse, but with a harmless liquid that will act as a placebo. the study will be carried out in the zaragoza iii health sector, with patients belonging to the zaragoza ii health sector, collaborating with the "seminario" health center and the lozano blesa clinical university hospital (hculb). this project will be carried out in accordance with the consort guidelines for clinical trials.

Eligibility criteria:
inclusion criteria: * outpatients older than 18 years and younger than 80 years. * patients with a medical indication for a diagnostic test for active infection to sars-cov-2 * patients who present mild symptoms typical of covid-19 and who have less than three days of evolution * patients who have cognitive and motor skills to perform mouthwash correctly. * patients who understand and speak spanish * patients who freely give their consent to participate in the study, after a correct understanding of its objectives and procedures. exclusion criteria: * patients with hospitalization criteria (moderate or severe symptoms) * vulnerable populations such as pregnant, lactating, * patients with recent medical diagnosis (≤ 1 month) of pneumonia * patients with hyposialia * patients with consumption of oral antiseptics (in the form of mouthwash containing cpc, povidone iodine rinses, alcohol mouthwash and essential oils) and toothpastes with cpc during the last month. * patients with cognitive impairment

Keywords: cetylpyridinium sars-cov-2 covid-19 mouthwashes
biobased polyester versus synthetic fiberglass casts for treating stable upper limb fractures in children

Conditions: Upper Limb Fracture

Summary: from feb 2022 to nov 2022, we undertook a single-center prospective randomized trial involving 100 children with cast-immobilized stable upper limb fractures. these patients were randomized into either biobased polyester or synthetic fiberglass groups. all patients were regularly followed up till the cast removal which occurred approximately 3-4 weeks after immobilizing. objective clinical findings and subjective patient questionnaire were all collected and analyzed.

the clinical trial was approved by the research ethics review committee of the author's hospital and informed consent was obtained from the legal guardian of each patient. between feb 2022 and nov 2022, all children (age range, 4-15 years) with radiography-diagnosed stable upper limb fractures (including radius, ulna, and distal humerus fractures such as garland type i supracondylar fractures of the humerus) \[9\] diagnosed at the orthopedic outpatient clinic or emergency room of a tertiary trauma center hospital were eligible for recruitment.

Eligibility criteria:
inclusion criteria: * stable upper limb fractures (including radius, ulna, and distal humerus fractures such as garland type i supracondylar fractures of the humerus) diagnosed at the orthopedic outpatient clinic or emergency room of a tertiary trauma center hospital exclusion criteria: * displaced or unstable fractures indicated for close or open reduction and fixation * previous surgeries to the affected upper limb * history of any chronic skin pathology (e.g., atopic dermatitis) * known allergy to cast materials

Keywords: pediatric upper limb fracture casting bioabased polyester synthetic cast
feasibility of a walking program for cancer survivors receiving radiation therapy

Conditions: Physical Activity

Summary: this pilot study will assess whether a supported pedometer-based walking program is helpful in maintaining physical activity for breast and head-and-neck cancer patients who are undergoing radiation therapy. follow-up monitoring sessions will be scheduled to help provide support for physical activity during radiation therapy. we will also examine the relationship of physical activity and quality of life outcomes to help inform future research.

will the integration of a patient-centered exercise prescription and supportive counseling attenuate declines in physical activity during radiation therapy? to address this question, this study will assess the feasibility of a patient-centered walking program for breast and head-and-neck cancer patients undergoing radiation therapy. follow-up monitoring sessions will be scheduled to help provide support and ongoing counseling to facilitate increased activity (through walking) during radiation therapy. we will also examine the effect of the walking program on other outcomes such as happiness, depression and sleep to determine point estimates and measures of variability to inform future research.

Eligibility criteria:
inclusion criteria: * survivors with a diagnosis of breast cancer or head and neck cancer * adults aged 18 years or older * commencing adjuvant radiation therapy treatments * karnofsky performance status greater than or equal to 60% exclusion criteria: * clinical or radiological evidence of active disease, either local or metastatic * serious non-malignant disease, such as cardiac failure or advanced arthritis of weight bearing joints, which would preclude daily treatment and follow-up * patients for whom physical activity or exercise is contraindicated * psychiatric or addictive disorders which preclude obtaining informed consent or adherence to the protocol * unable to comply with the protocol, measurement and follow-up schedule (e.g., scheduling conflicts, time commitment)

Keywords: physical activity exercise quality of life radiation therapy breast cancer head and neck cancer