Kornimate/medical-research-clean huggingface dataset:
ai-ebus-elastography for ln staging

Conditions: Artificial Intelligence; Endobronchial Ultrasound; Elastography; NSCLC; Lung Cancer

Summary: before any treatment decisions are made for patients with lung cancer, it is crucial to determine whether the cancer has spread to the lymph nodes in the chest. traditionally, this is determined by taking biopsy samples from these lymph nodes, using the endobronchial ultrasound transbronchial needle aspiration (ebus-tbna) procedure. unfortunately, in 40% of the time, the results of ebus-tbna are not informative and wrong treatment decisions are made. there is, therefore, a recognized need for a better way to determine whether the cancer has spread to the lymph nodes in the chest. the investigators believe that elastography, a recently discovered imaging technology, can fulfill this need. in this study, the investigators are proposing to determine whether elastography can diagnose cancer in the lymph nodes. elastography determines the tissue stiffness in the different parts of the lymph node and generates a colour map, where the stiffest part of the lymph node appears blue, and the softest part appears red. it has been proposed that if a lymph node is predominantly blue, then it contains cancer, and if it is predominantly red, then it is benign. to study this, the investigators have designed an experiment where the lymph nodes are imaged by ebus-elastography, and the images are subsequently analyzed by a computer algorithm using artificial intelligence. the algorithm will be trained to read the images first, and then predict whether these images show cancer in the lymph node. to evaluate the success of the algorithm, the investigators will compare its predictions to the pathology results from the lymph node biopsies or surgical specimens.


Eligibility criteria:
inclusion criteria: * patients that are diagnosed with suspected or confirmed nsclc that have been referred to mediastinal staging through ebus-tbna at st. joseph's healthcare hamilton will be eligible for this study. exclusion criteria: * no exclusion criteria will apply.
a study to investigate the safety and efficacy properties of pf-00547659 in patients with active ulcerative colitis

Conditions: Colitis, Ulcerative

Summary: study to investigate the safety and efficacy properties of pf-00547659 in patients with active ulcerative colitis


Eligibility criteria:
inclusion criteria: * a positive histological diagnosis of uc ≥3 months prior to entry into the study. if a histological diagnosis is not available but all signs and symptoms suggest uc, the subject's eligibility should be discussed with pfizer. * active uc as defined by a score of ≥6 on the mayo score. * an endoscopic (by flexible sigmoidoscopy) sub-score of ≥2 on the mayo score determined within 7 days of first dosing. exclusion criteria: * subjects with uc, which is confined to a proctitis on a flexible sigmoidoscopy. * subjects who have had surgery as a treatment for uc or are likely to require surgery within the duration of the study. * subjects displaying clinical signs of ischemic colitis.
metabolic impact of time restricted feeding

Conditions: Obesity; Diet Modification

Summary: the investigators are interested in how time-restricted feeding will impact weight, sleep duration and efficacy, and activity levels in obese adults. significant advances in digital mobile technology allow detailed measures of an individual's habits, permitting the opportunity for personalized dietary and lifestyle recommendations. this is especially relevant as time-restricted feeding appears to promote weight loss independent of calorie intake, potentially shifting the paradigm of dietary recommendations from a calorie-based to a time-based perspective.

given the obesity epidemic, there is intense medical and public interest in dietary and lifestyle management to mitigate obesity and its associated complications. although weight loss has traditionally focused on restricting calories, it is well described that most people are unable to maintain the caloric restriction required to long term weight loss or maintenance. this proposal will address whether restricting the timing of food intake, rather than restricting calories, may facilitate weight loss and provide metabolic benefits. it has been recently shown that the average american eats over the course of 15 hours per day. such an eating cycle dictates that most people are always in a fed metabolic state and likely misaligns circadian patterns. time-restricted feeding (trf) is the process of limiting food consumption to a specific window of time (e.g. 8 hours per day) and is associated with weight loss in humans and metabolic improvements in rodent studies. significant advances in digital mobile technology now allow further detailed measures of an individual's habits to facilitate this analysis. thus, the objective of this study is to test the health related effects of 12 week trf (8 hour fed and 16 hour fasting cycle) in overweight/obese adults. the investigators hypothesize that trf will 1) improve sleep duration, sleep efficacy, increase activity and increase basal metabolic rate, 2) promote weight loss and lower body fat, and 3) improve insulin sensitivity and postprandial hyperglycemia. the investigators expect these studies to show that trf is effective and sustainable approach to improving metabolic parameters in overweight/obese individuals.

Eligibility criteria:
inclusion criteria: 1. age 18-65 2. bmi ≥ 25 3. stable sleep and work schedule 4. owns a smart phone 5. capable of giving informed consent exclusion criteria: 1. pregnant 2. nursing 3. anticipation of pregnancy during the course of the study 4. clinically significant medical issues as determined by the study clinician

Keywords: obesity, diet, sleep activity
c.a.p.a.b.l.e. (cross-training and physical activity: a better life experience study)

Conditions: Cancer Survivors

Summary: this study will introduce cancer survivors to cross-training with the expectation that the program proposed will ultimately result in superior improvements in functional performance, body composition and quality of life compared with the current american cancer society (acs) guidelines for cancer survivors.

a 12-week pilot intervention study introducing a high-intensity functional training program to 100 cancer survivors and evaluate the effects of this program on patient quality of life, functional capacity, and body composition. response rates will be determined using various recruitment methods and estimate differences in response rates by patient characteristics including race, gender and age. barriers to participation in the program in contacted patients who do not enroll as well as patients who enroll and do not complete the program will be described, as will participant satisfaction with enrolled participants who complete the program. the goal of this pilot study is to help refine the recruitment and program methods for a larger intervention study to test the superiority of a high-intensity interval functional training program compared with current american cancer society guidelines in improving functional capacity, body composition and patient reported quality of life. surveys will be completed by each participant weekly and physical assessments will be completed monthly.

Eligibility criteria:
inclusion criteria: * aged 18 years or older at time of program recruitment * diagnosed with an invasive cancer * cleared from their physician to participate in the program (we assume that most patients will have completed treatment, however if a patient is currently under treatment, this should be their oncologist. if the patient is not currently undergoing treatment, this could be primary care physician or oncologist). * available transportation to and from the facility on session days
action medical research

Conditions: Learning Disabilities

Summary: learning disability affects 3% of the population. severe types of learning disability are more likely to have an underlying genetic cause but diagnosis is difficult because many different genetic abnormalities may be involved. obtaining a diagnosis is important so that patients can be managed appropriately and their families can be given accurate information. we aim to use new types of genetic testing which will make it possible to screen for several different genetic abnormalities which cause learning disability at the same time, so improving the accuracy and speed of diagnosis in the group of patients with severe learning disability. we will focus particularly on patients where seizures and behavioural problems are also present.this will enable more patients to be diagnosed accurately, reduce the number of hospital appointments needed and ultimately be more cost- effective.


Eligibility criteria:
inclusion criteria: * individuals with severe learning disability associated with either seizures, movement or behaviour problems who had previously undergone routine investigation but where no cause had been identified for their problems exclusion criteria: * individuals with sld where the cause is already known * individuals where informed consent cannot be obtained for participation
irbesartan in chinese hypertensive diabetics with microalbuminuria

Conditions: Hypertension

Summary: primary objective: * to determine if irbesartan 300mg is better than 150mg in protecting the kidneys in hypertensive patients with diabetes and microalbuminuria. secondary objectives: * to determine how well irbesartan 300mg is tolerated versus 150mg * to determine the percentage of patients reaching the blood pressure target of 130/80 mmhg


Eligibility criteria:
inclusion criteria: * hypertensive patients, treated or untreated, with type 2 diabetes and urinary albumin excretion rate 20-200ug/min. * blood pressure of \< 180/110mmhg at baseline * normal serum creatinine exclusion criteria: * type 1 diabetes * use of angiotensin converting enzyme inhibitors or angiotensin receptor blockers in the 5 weeks before recruitment * pregnant or lactating women * severe hypertension * overt nephropathy * allergy to study drug the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
enhanced tuberculosis case detection among substitution treatment patients

Conditions: Tuberculosis

Summary: the purpose of this study was to determine the prevalence of latent tuberculosis infection among injecting drug users and to conduct randomized controlled trial to evaluate a case management intervention aimed at increasing tb screening and treatment entry among injecting drug users referred from a methadone drug treatment program in estonia.


Eligibility criteria:
inclusion criteria: * participation in substitution treatment program, * age 18 years or more, * able to read and write in estonian or russian, * able to provide informed consent

Keywords: tuberculosis injecting drug users case management
internal limiting membrane peeling on retinal displacement

Conditions: Internal Limiting Membrane Peeling

Summary: the purpose of this study is to investigate displacement of the retina after idiopathic macular hole surgery with different internal limiting membrane peeling patterns.

after being informed about the study and potential risks, all patients giving written informed consent will undergo a 1-week screening period to determine eligibility for study entry. all patients with idiopathic mh will be randomly allocated into two groups, n-t group or t-n group.

Eligibility criteria:
inclusion criteria: eyes with idiopathic macular hole exclusion criteria: eyes having re-do macular hole surgery, with high myopia, with proliferative vitreoretinopathy or with a retinal detachment combined with the mh, with other macular diseases, such as age-related macular degeneration.

Keywords: retinal displacement idiopathic macular hole internal limiting membrane peeling
investigation of mechanisms of action in superpower glass

Conditions: Autism Spectrum Disorder; Autism

Summary: the following study aims to understand the mechanism of action at work in a novel artificial intelligence (ai) tool that runs on google glass through an android app to deliver social emotion cues to children with autism during social interactions. this study will examine 2 versions of software on the google glass based wearable intervention system. participants will receive 1 of 2 versions of the software and use the device at home for 4 weeks. this novel device will use a camera, microphone, head motion tracker to analyze the behavior of the subject during interactions with other people. the system is designed to give participants non-interruptive social cues in real-time and will record social responses that can later be used to help aid behavioral therapy. it is hypothesized that both mechanisms under investigation will contribute to social gains in children over the 4 week period of use.


Eligibility criteria:
inclusion criteria: * parent of a child with a professional diagnosis of autism who is at least 18 years old. * child with autism is 4-8 years old * parent/guardian is able to drive to stanford university for 2 in lab appointments.(lives within driving distance of stanford university). exclusion criteria: * parent/guardian unable to speak and read in english. * child with autism receives social communication questionnaire score\>15

Keywords: digital autism mobile health asd mobile therapy google glass wearable computing technology
granulocyte-colony stimulating factor for stem cells therapy for acute ischemic stroke

Conditions: Ischemic Stroke

Summary: the aim of the study is to investigate treatment with leukostim (filgrastim; granulocyte-colony stimulating factor; g-csf) for acute ischemic stroke.

stroke is one of the main reasons of mortality and morbidity all over the world. in economically developed countries stroke takes 2 or 3 place in the structure of morbidity and mortality. in animal models, it was shown that autological stem cells transplantation significantly increased perfusion of ischemic area and improved lost motor and sensor functions. granulocyte-colony stimulating factor (g-csf) was used in some clinical trials without following autological transplantation. however, there are no enough evidence-based proved results of g-gsf safety and effectiveness in acute ischemic stroke. in order to determine safety and efficiency of g-csf administration together with conventional treatment and conventional intensive care protocol during acute ischemic stroke we organized this clinical trial.

Eligibility criteria:
inclusion criteria: * age between 40 to 70 years old * ct/mri confirmed ischemic stroke in carotid area during 48 hours after the onset of clinical signs * level of conscious lower than 15 and higher than 8 points by the glasgow coma scale * acute extremity paresis lower than 4 points by medical research consul scale exclusion criteria: * premorbid dependency (modified rankin scale \> 0) * intracerebral hemorrhage * transitory ischemic attack * patients with previous stroke * any disorders, that can affect interpretation of results (e.g. psychiatric or movement disorders) * hematological diseases * coagulopathy * malignancy * pregnancy and lactation * organ dysfunction that would preclude tests required for this study * known allergic reaction to g-csf or a component of g-csf * patients that have received a cytokine within the last 1 month or are currently receiving a cytokine treatment

Keywords: ischemic stroke stem cells colony-stimulating factors filgrastim randomized controlled trial
the effect of vegetarian diet on patients with metabolic associated fatty liver disease

Conditions: Metabolism and Nutrition Disorder; Liver Diseases; Obesity; Diet, Healthy

Summary: in this study, 18-60 years old patients with metabolic associated fatty liver disease（mafld） will be recruited to test the intervention effect of vegetarian diet. this randomized clinical trial randomized individuals to a healthy vegetarian diet or a healthy omnivorous diet for 24 weeks. at the baseline and after the 24week intervention, the clinical manifestations of mafld, obesity levels, indices for glucose and lipid metabolism parameters, results of questionnaire and fecal samples will be collected and analyzed.

dietary control remains an important way for nutritional intervention of metabolic related fatty liver disease. however, studies shows that patients have low compliance to the traditional diet. the topic proposed based on previous studies，recruiting of 220 obesity patients with metabolic associated fatty liver disease aged 18-60. after the informed consent, they will be randomly divided into intervention group and control group, intervention group will be given healthy vegetarian diet intervention and the control group given healthy omnivorous diet. both diets are in line with the principles of fatty liver treatment. interventions consisted primarily of face-to -face interview monthly and online interview every 2 weeks, which will be performed by professional dietitians. all participants were asked not to alter their exercise patterns during the study period. the primary outcome was the weight of fat mass after 24 weeks intervention. secondary outcomes included imaging findings (b-ultrasonic examination and fibroscan) of mafld, liver function, anthropometric measures, plasma lipid and glucose levels. at the meantime, serum oxidative stress indices, results of compliance survey and metabolites of intestinal flora will be collected and analyzed. through the above detection of the indicators related to mafld and obesity, it is explored whether the vegetarian diet can be an efficient and feasible way to the nutritional therapy of mafld.

Eligibility criteria:
inclusion criteria: 1. clinically diagnosed as fatty liver, and bmi≥24.0kg/m²; 2. 18-60 years old; 3. have not received drug treatment if having hyperglycemia, hyperlipidemia and high uric acid ; 4. no antibiotics in the last 1 month; 5. the guardian's informed consent; exclusion criteria: 1. have received drug treatment of fatty liver disease within three months; 2. patients with with liver cirrhosis, viral hepatitis and other liver diseases; 3. patients with serious heart, lung, kidney diseases and patients with cancer; 4. pregnant and nursing women; 5. other conditions that may affect the results of the study

Keywords: metabolism associated fatty liver disease obesity vegetarian diet diet intervention
the contribution of incretin hormones to post-prandial glucose metabolism after roux-en-y gastric bypass

Conditions: Type 2 Diabetes Mellitus

Summary: the study is being undertaken to understand how the roux-en-y gastric bypass procedure can affect insulin secretion after meals. the hypothesis of this study is the disposition index is decreased in subjects who had previously undergone roux-en-y gastric bypass by glucagon-like peptide-1 (glp-1) receptor blockade.


Eligibility criteria:
inclusion criteria roux-en-y gastric bypass (rygb)subjects: * subjects who have undergone rygb inclusion criteria healthy subjects: * must match rygb subjects in age, weight, and gender * subjects will be without active systemic illness exclusion criteria all subjects: * subjects \ 70 years old * for female subjects: positive pregnancy text at the time of enrollment or study * subjects with functional or organic bowel symptoms.

Keywords: gastric bypass bariatric surgery carbohydrate metabolism
effect of sodium rinsing fluid on blood pressure and interdialytic weight change in hemodialysis patients

Conditions: End-Stage Kidney Disease; Hemodialysis

Summary: this is a prospective, randomized, double-blind, parallel group trial to assess the efficacy and safety of intravenous dextrose 5% solution compare with normal saline (standard care) in wash back procedure during haemodialysis in patients with end stage renal failure (esrf) with respect to systolic blood pressure control over 3 months period. the primary objective is to establish efficacy of 5% dextrose solution compared with normal saline (0.9% sodium chloride solution) with respect to systolic blood pressure control in subjects with end stage renal failure (esrf) on regular hemodialysis. secondary objectives include monitoring the change in body weight, thirst level and body fluid volume.


Eligibility criteria:
inclusion criteria: * ambulatory, clinically stable maintenance hd patients on a thrice weekly hd regime. * have regular hemodialysisforat least 6 months or more. * willing and able to provide written, signed informed consent after the nature of the study has been explained. * willing and able to comply with all study procedures. * age ≥18 years; age \< 75 years old exclusion criteria: * diabetes mellitus, malignancy, pregnancy * inability or unwillingness to provide written consent. * inability or unwillingness to comply with the requirements of the protocol as determined by the investigator. * simultaneous participation in another clinical study except observational trials * any psychological condition which could interfere with the patient's ability to comply with the study protocol * inability to perform a blood pressure measurement on the upper limb * scheduled for living donor kidney transplant, change to peritoneal dialysis, home hd or plans to relocate to another center during the study period. * life expectancy \< 6 months * recent acute myocardial infarction, congestive cardiac failure, stroke, angina or icu admission within last 6 months, * planned to migrate/move out of the city * alcohol abuse/ drug abuse within last 6 months * missed \> 2 hemodialysis sessions over 1 month * requiring non- cuff catheter for hemodialysis * admitted for major infection within the last one month

Keywords: normal saline destrose 5% blood pressure interdialytic weight gain thirst level end stage renal failure
the feasibility of propofol tci in hemodialysis patients undergoing arteriovenous shunt surgery

Conditions: End Stage Renal Disease; Hemodialysis Complication

Summary: written informed consent must be obtained before any study specific procedures are undertaken. informed consent will be obtained during pre-operative assessment.

the investigators will recruit 80 patients undergoing av shunt surgery. all patients will receive general anesthesia and brachial plexus block. patients will be randomly allocated into two groups. study and control group received propofol target-controlled infusion (tci) and inhaled anesthetics as anesthesia maintenance, respectively. main outcomes will be assessed by perioperative blood pressure, heart rate, respiratory rate, end-tidal co2, analgesics dosage, pain intensity and perioperative adverse events.

Eligibility criteria:
inclusion criteria: * uremic adult(over20-year-old)patients under going arteriovenous (av) shunt surgery exclusion criteria: * one of below systemic diseases; chronic pulmonary, cardiac diseases(such as copd, asthma, acute myoischemia), hepatic co-mobility(such as liver cirrhosis), morbid obesity, alcoholism, allergy to propofol and inhaled anesthetics, the women who are pregnant or breastfeeding