Kornimate/medical-research-clean huggingface dataset:
platelet rich plasma and supraspinatus tear

Conditions: Supraspinatus Tear

Summary: rheumatology and rehabilitation department, mansoura university hospital. forty patients with chronic partial supraspinatus tears will be included in the study. the diagnosis of the supraspinatus tear will be made by ultrasound examination

at inclusion in the study, demographic data (age, gender, duration of complaints, and body mass index) will be recorded. randomization patients will be randomized into two matched groups: a) prp-injection group - patients in this group will receive three ultrasound guided prp injections in the supraspinatus tendon with one week interval (ilhanli et al., 2015). after the injection, patients will be instructed to limit the use of shoulder for at least 24 hours and to use cold therapy for pain. after the third injection, rom, and stretching exercises will be allowed and one month after the end of injections, patients will be recommended to begin the strengthening program as tolerated. exercise is performed with 10 repeats five sessions per week. b) physical therapy group - patients in this group will be treated with hot pack for 15 minutes, ultrasound in continuous mode (1.5 watt/cm2 for five minutes), trans-cutaneous electrical nerve stimulation in brief-intense mode for 15 minutes, range of motion (rom), followed by stretching and strengthening exercises with 10 repeats 15 sessions (five sessions per week for three weeks). after the physical therapy, the exercise program will be continued as homework during the follow-up period. patients in t

Eligibility criteria:
inclusion criteria: chronic partial supraspinatus tears will be included in the study exclusion criteria: age \> 80 years, pregnancy, full thickness supraspinatus tears, other rotator cuff lesions with/without supraspinatus tears, systemic disorders such as diabetes rheumatoid arthritis, hematological diseases (co-agulopathy),
bisphosphonate treatment of osteogenesis imperfecta

Conditions: Osteogenesis Imperfecta

Summary: the primary purpose of this trial is to evaluate whether the investigational medication is safe, effective and has the ability to increase spine bone density in osteogenesis imperfecta (oi) patients.


Eligibility criteria:
inclusion * male or female children between 3 months and 17 years old * oi type i, iii or iv exclusion * deformity or abnormality which would prevent spine bone density from being done * any surgical bone-lengthening procedure * any kidney diseases or abnormalities * low calcium or vitamin d levels in the blood other protocol-defined inclusion/exclusion criteria may apply.

Keywords: osteogenesis imperfecta oi bone markers fracture bone loss pediatric bisphosphonate brittle bone disease pamidronate
anesthetic efficacy of 2% mepivacaine versus 4% articaine

Conditions: Symptomatic Irreversible Pulpitis

Summary: the aim of this prospective randomized clinical trial was compare between 2% mepivacaine and 4% articaine for inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis in mandibular molars as regards to their anesthetic efficiency; during access cavity preparation and instrumentation.

sixty-six patients diagnosed clinically and radiographically with symptomatic irreversible pulpitis in mandibular posterior teeth will received single-visit root canal treatment using protaper universal rotary system for canal preparation, then they will be randomly divided into two groups (n=33) according to the anesthetic solution used, either group m (3.6 ml mepivacaine hydrochloride 2% with 1:100000 epinephrine) or group a (3.4 ml articaine hydrochloride 4% with 1:100000 epinephrine). the pain will be assessed using numerical rating scale (nrs) during access cavity preparation and instrumentation, then the need for supplemental anesthesia will be also recorded.

Eligibility criteria:
inclusion criteria: 1. patients in good health (american society of anesthesiologists class ii or higher) 2. patients having symptomatic irreversible pulpitis in one of their mandibular molars. 3. age range is between 20 and 50 years. 4. patients who can understand visual analogue scales vas. 5. patients able to sign informed consent exclusion criteria: 1. patients allergic to articaine and/or mepivacaine and/or sulfur 2. patients having active sites of pathosis in the area of injection. 3. patients having active pain in more than one molar. 4. patients who had taken analgesics in the 12 hours preceding the injection.

Keywords: anesthetic efficacy inferior alveolar nerve blocks
a pilot registry for ultrasound-guided pharmacopuncture

Conditions: Neck Pain; Back Pain

Summary: a pilot study of prospective resigstry to evaluate the safety and efficacy of ultrasound-guided pharmacopuncture for spinal disorders

this study aims to evaluate the safety and efficacy of ultrasound-guided pharmacopuncture by collecting information on adverse reactions, efficacy assessment variables, and treatment methods from patients diagnosed with spinal disorders who have undergone ultrasound-guided pharmacopuncture treatment.

Eligibility criteria:
inclusion criteria: 1. individuals diagnosed with spinal disorders (m code and s code based on kcd criteria) 2. outpatients scheduled for ultrasound-guided pharmacopuncture treatment 3. individuals aged 19 years or older and under 70 years 4. individuals who agree to participate in the clinical study and voluntarily sign the consent form exclusion criteria: 1. individuals who are unable to complete the consent form 2. individuals who are deemed unsuitable for participation in the clinical study by the researcher
information extraction and database construction for emergent patients based on voice and image recognition technology

Conditions: Emergencies

Summary: video and audio data of the triage process of emergency department (ed) patients will be collected to build a database. clinical information retrieved from the database with voice and image technology will be used to determine the triage level of each patient and will be compared with the actual triage level.

study objectives: 1. to develop a platform to record video and audio data of the ed triage process. 2. to retrieve clinical information using voice and image technology. 3. to develop a tool to determine ed triage level using voice and image technology. 4. to build a clinical database using video and audio data using voice and image technology. study design: single center observational study (tertiary hospital emergency department in korea). a platform to record video and audio data of the ed triage process will be developed. the camera and microphone will be installed at an optimal location to retrieve video and audio data in the ed triage area. voice and image technology will be used to retrieve clinical information including demographic information, chief complaint, type and onset of symptoms, past medical history, and physical examination results to build a database. clinical information including examination notes, diagnosis, patient vital signs, test results, and ed results will be retrieved from the hospital database.

Eligibility criteria:
inclusion criteria: * age 19 years or older * visited the emergency department of the study hospital exclusion criteria: * patients who do not agree to enroll to this study * without a family * foreign patients

Keywords: triage emergency department voice recognition image recognition
association between telomere length and risk of acute coronary syndrome

Conditions: Acute Coronary Syndrome

Summary: compelling epidemiological evidence indicates that alterations length of telomere, are associated with the initiation and development of ischemic heart disease. this study was undertaken to investigate whether mtdna copy number in peripheral blood leukocyte could be used as a risk predictor for acute coronary syndrome.


Eligibility criteria:
inclusion criteria: -1.history of documented myocardial infarction; 2.prior coronary revascularization intervention (coronary artery bypass graft surgery or percutaneous coronary intervention); 3.the presence of≥50% stenosis in one or more coronary arteries identified during cardiac catheterization; exclusion criteria: -1.history of malignancy or end-stage renal disease; 2.blood transfusion within one month or prior bone marrow transplantation 3.patients who reluctant to sign informed consent

Keywords: acute coronary syndrome, telomere length, predictive factor
diet, exercise and cardiovascular health among ethnic children

Conditions: Cardiovascular Diseases; Heart Diseases; Obesity

Summary: to document the patterns of influence or socialization from parents to children in regard to the transmission of cardiovascular disease risk related behaviors such as diet and physical activity.

background: while much of the research in heart disease prevention has focused on relationships among cardiovascular disease risk factors, cardiovascular disease morbidity and mortality, there is a growing recognition of the importance of various health behaviors, such as what people eat, how much they exercise, if they smoke, their habitual approach to life including type a behavior. many of these risk related behaviors are correlated with the various cardiovascular disease risks. this study determined differences in social influence patterns in regard to diet and exercise between obese and non-obese families, and the impact on the obesity, dietary and exercise habits, and risk factors of children beginning at three to four years of age until seven to eight years. design narrative: this prospective, longitudinal study collected data on the twelve cohorts of families. blood pressures, resting pulse, height, weight, skinfolds, plasma cholesterol fractions and type a behavior data were collected on the children at five times over the course of five years. during the four years between each of the clinic measurements, observational data were collected on the diet and exercise habits of the children. at the time of clinic assessment, clinic data were also collected on the parents of the children and self report data on the parents' diet, exercise habits, and other psychosocial variables. two substudies were also conducted. the first assessed energy expenditure levels of children in the three age groups of 3-4 years, 5-6 years, and 7-8 years and the three body types of lean, average, and obese in 12 different activities. the second substudy assessed the accuracy of mothers' 24-hour recall of the diet and exercise behaviors of their 3-4 year old children as compared to observational data on the same behaviors.

Eligibility criteria:
no eligibility criteria
post authorisation safety study with raxone in lhon patients

Conditions: Leber's Hereditary Optic Neuropathy (LHON)

Summary: this study is a multicentre, prospective, non-interventional post-authorisation safety study (pass) of the clinical outcomes for patients with lhon treated with raxone®. no medication will be provided as part of this study. raxone® will be obtained through commercial channels.


Eligibility criteria:
inclusion criteria: * patient prescribed raxone® for the treatment of lhon; * patient has completed an informed consent form (icf) indicating that he/she (or a legally acceptable representative) has been informed of all pertinent aspects of the study and has agreed to participate in the study; * patient is not participating in any interventional study. exclusion criteria: * no explicit exclusion criteria exist to avoid selection bias and to allow for documentation of routine clinical practice.
outcome of two different suture methods for achilles tendon rupture

Conditions: Achilles Tendon Rupture

Summary: the purpose of this study is to estimate the effective of two suture methods in the treatment of achilles rupture.

achilles tendon rupture is one of the most common tendon injuries in the adult population. the incidence of this injury is increasing as aging adults continue their participation in high-demand sports. although the impact of an achilles tendon rupture is substantial, often resulting in prolonged disability and rehabilitation. studies have showed that the operation treatment of acute achilles tendon ruptures had some advantages. but the rebuild of blood supply was not involved in previous studies. and the epitenon of tendon is the interior layer, closest to the endotenons which contains the vascular supply. main difference of two suture methods were if the epitenon was repaired and sewed indirectly or unrepaired and sewed directly.

Eligibility criteria:
inclusion criteria: * adult men or women between 18 and 60 years of age. * closed rupture confirmed with ultrasound or magnetic resonance imaging (mri). * operative within 14 days after injury. * willing and able to comply with and carry out the prescribed rehabilitation protocol. * providing informed consent. * no other major trauma. exclusion criteria: * refuse to participate. * refuse to participate. * additional ipsilateral injury. * open injury. * patients not suitable for surgery (i.e., mellitus diabetes, immunocompromised states, obesity (bmi.30), peripheral vascular disease or local/systemic dermatologic disorders) or have other surgical contraindications. * fluoroquinolone-associated rupture (i.e., rupture within 2 weeks after taking this medication). * achilles avulsion from the calcaneus or with bone fracture. * neurological or vascular disease requiring medications recognized to impair tendon healing.

Keywords: surgery suture method blood supply
mycophenolate mofetil treatment with neuromyelitis optica spectrum disorders in chinese patients

Conditions: Neuromyelitis Optica Spectrum Disorders; Mycophenolate Mofetil; Efficacy and Safety

Summary: neuromyelitis optica (nmo) is an autoimmune inflammatory demyelinating disease of the central nervous system that leads to blindness and paralysis. since disability accrues incrementally related to attacks, attack prevention with immunosuppressive therapy is the mainstay of preventing disability. however, there is no standard immunosuppressive treatment strategy for nmo relapse prevention. in a previous study, the investigators provided evidence supporting the use of azathioprine plus a low dose corticosteroid as an effective strategy which is associated with a reduction in the risk of relapse in chinese patients with nmo, but azathioprine has bone marrow suppression and other side effects. mycophenolate mofetil (mmf) is a new immunosuppressant with rapid onset, fewer side effects and other advantages. in recent years, mmf has been used in different immune-related neurological diseases; some literature shown the possible efficacy of mmf in nmo treatment. in this research, a multi-center (third affiliated hospital of sun yat-sen university, zhongshan ophthalmic centre of sun yat-sen university, nangfang hospital of southern medical university) study will carry out to evaluate the efficacy and safety of mycophenolate mofetil therapy in nmo spectrum disorders.


Eligibility criteria:
inclusion criteria: * meet the 2006 wingerchuk diagnostic criteria; * nmo-immunoglobulin g seropositive; * between 18 to 65 years old; * relapse: more than 2 relapses in recent 2 years; more than 1 relapses in recent 1 years; * expanded disability status scale: expanded disability status scale≤7.0, and visual acuity ≥20 / 100 at least in one eye * understand the purpose and procedures of this study, and written informed consent is obtained. exclusion criteria: * using immunosuppressive agents and other drugs affect evaluation, and drug withdrawal less than 3 months; * patients with any of the following diseases: transaminases elevation exceed 2 times of the normal upper limit; white blood cell \<4 × 109 / l, hemoglobin \<80g / l, platelet \<100 × 109 / l; * with serious cardiovascular, liver, kidneys and other vital organs and blood, endocrine system diseases, cancer history; * with immunodeficiency, uncontrolled infection and active gastrointestinal diseases (such as gastric ulcer, etc.); * pregnancy, breast-feeding women and male or female who plans to conceive recently; * allergy to mycophenolate mofetil and prednisone.
re-infusion of unwashed shed blood during off-pump surgery

Conditions: Coronary Artery Disease; Blood Transfusion Complication; Cardiovascular Complication

Summary: to assess the efficacy and side-effects of re-infusion of unwashed shed blood during off-pump coronary artery surgery using a novel cardiotomy circuit.

introduction blood transfusion is often required during cardiac surgical operations, and may be associated with known risks and complications. off-pump coronary artery surgery has been shown to be associated with reduced need for blood transfusion, and cell-savers are widely used as an additional method for reducing blood transfusion demands. auto-transfusion of unwashed suctioned blood intra-operatively is thought to increase the inflammatory response and infective complications, but data related to this approach are scares. aims to assess the effects and benefits of using an isolated cardiotomy circuit for re-infusion of unwashed shed blood during off-pump surgery and compare it to the conventional no re-infusion technique. assessments will focus on: * clinical outcome * transfusion requirements * inflammatory response * alveolar/arterial oxygen pressure gradients * cognitive status * cost-benefit study design a prospective study involving patients undergoing off-pump coronary artery bypass surgery. patients will be randomized to two groups; an isolated cardiotomy circuit for re-infusion of unwashed shed blood will be used in group (a) and the conventional no re-infusion technique will be used in group (b). participants patients undergoing off-pump coronary artery bypass surgery. setting damascus university cardiac surgery hospital

Eligibility criteria:
inclusion criteria: * all patients undergoing isolated off-pump coronary artery bypass surgery between march 1st, 2024 and march 31st, 2026. exclusion criteria: * missing data. * patients outside the study period. * patients under the age of 40 years or over the age of 75 years. * patients with impaired left ventricular function (ef less the 40%). * patients with history of renal failure, hepatic failure, cva, or tia. * patients who have not stopped anticoagulants (except aspirin) for 4 days preoperatively. * emergency operations.

Keywords: surgery coronary artery bypass grafting blood off-pump auto-transfusion
palliative care for heart failure patients

Conditions: Heart Failure

Summary: the purpose of this study is to assess the impact of palliative care consultation on quality of life and symptom management for patients hospitalized with acute heart failure with a randomized control trial at abbott northwestern hospital.

research questions: q1. does the provision of palliative care to heart failure patients yield higher quality of life, increased symptom management, or reduced depression compared to heart failure patients not receiving palliative care? q2. does the provision of palliative care to heart failure patients result in differential use of medical services (lower hospital days and readmission) compared to heart failure patients not receiving systematic palliative care?

Eligibility criteria:
inclusion criteria: * abbott northwestern hospital inpatient adults with a diagnosis of acute heart failure exclusion criteria: * are not an inpatient at abbott northwestern hospital * are in the icu * on a ventilator * are pre-or post heart transplant * have a ventricular assist device (vad) * determined to be actively dying * have cognitive impairments such that informed consent would not be possible, * are not proficient in the english language

Keywords: congestive heart failure heart failure palliative care palliative medicine
new causes and predictors for the development of atrial fibrillation and its complications

Conditions: Complications of Atrial Fibrillation

Summary: atrial fibrillation (af) is the most common sustained cardiac arrhythmia and its prevalence increases with aging of the population. it is reflected in the ecg recording by the replacement of regular p-waves by an undulating baseline and irregular ventricular complexes \[2\]. the uncoordinated atrial activity prevents effective atrial contraction, leading to clot formation. atrial fibrillation contributes significantly to population morbidity and mortality, and presently available therapeutic approaches have major limitations, including limited efficacy and potentially serious side effects. it can be classified into one of the three following categories: 1. paroxysmal: self-termination within 7 days 2. persistent: requires termination by pharmacological or direct-current electric cardioversion 3. permanent: restoration to sinus rhythm is impossible or inadvisable it is believed that in many cases the natural history of af involves evolution from paroxysmal to persistent to permanent forms through the influence of atrial remodeling caused by the arrhythmia itself and/or progression of underlying heart disease. as many underlying conditions contribute to the development and progression of af, the full and exact mechanisms standing behind this common arrhythmia are not completely or sufficiently understood. thromboembolism is by far the most important complication of af, and the most common factor in stroke in the elderly. the determinants of virchow triad, including stasis, endothelial damage, and coagulation properties, are centrally involved in af- related thrombus formation. hence, thorough searching for new possible causes or contributing factors for the developing and progression of af and its most threatening complication, thromboembolism, is mandatory the aim of the study is to look for new possible causes of atrial fibrillation and its complications.

this is an observational historical prospective study. all patients admitted to the rambam health care campus between 1.1.2007 and 31.11.2011 with the primary diagnosis with acute atrial fibrillation and were 18 years old or older at the time of diagnosis, will be included in this historical prospective study. patients' demographic data, medical history, permanent medications, laboratory studies, electrocardiographic and echocardiographic reports will be collected from the radiologic information system; a computed medical registry. after collecting the data, statistical analysis will be performed aiming to discover possible causes or predictors for atrial fibrillation development and the occurrence of its adverse complications, especially thromboembolism.

Eligibility criteria:
inclusion criteria: * primary diagnosis with acute atrial fibrillation * 18 years old or older at the time of diagnosis * admitted between 1.1.2007 and 31.12.2011 exclusion criteria: -

Keywords: atrial fibrillation thromboembolism