Kornimate/medical-research-clean huggingface dataset:
osteopathic intervention in professional handball players

Conditions: Osteopathia

Summary: the aim is to study the effectiveness of a common osteopathic intervention in professional handball players on diaphragmatic contractility and its correlations with posture. this study has never been done in healthy subjects. it is a scientific process of objectification of an osteopathic technique commonly performed in this population. the main objective is to assess diaphragmatic contractibility using ultrasound after abdominal osteopathic intervention (omt).

the context is that of optimizing the performance of professional handball players. the aim is to study the effectiveness of a common osteopathic intervention in professional handball players on diaphragmatic contractility and its correlations with posture. this study has never been done in healthy subjects. it is a scientific process of objectification of an osteopathic technique commonly performed in this population. the main objective is to assess diaphragmatic contractibility after abdominal osteopathic intervention (omt). the secondary objective is to evaluate the impact of this manual intervention in professional handball players on: * other diaphragmatic ultrasound data * on spirometry * postural control prospective pilot non-interventional controlled monocentric study opened in healthy male and female international players who are part of the french handball team. approach to objectification of current practice.

Eligibility criteria:
inclusion criteria: * healthy male and female international players who are part of the french handball team exclusion criteria: * history of thoracic or diaphragmatic surgery

Keywords: diaphragm ultrasound contractibility osteopathic intervention
haemorrhoidectomy by ligasure and conventional surgery

Conditions: Ligature; Hemorrhage

Summary: comparison between haemorrhoidectomy by ligasure and conventional surgery

hemorrhoids, a varicose condition are one of the commonest illnesses which causes per rectal bleeding . hemorrhoidectomy is the standard operation for grades iii and iv hemorrhoids; it is superior to any proposed conservative procedure. conventional haemorrhoidectomy is the open surgical procedure in which the haemorrhoid pedicle is ligated by a transfixing suture which may lead to some postoperative complications mostly pain, bleeding and wound infection which ultimately cause prolonged stay in hospital. a number of surgeons believe that by avoiding vascular pedicle ligation the chances of secondary bleeding can be decreased .this stimulated the researchers to develop new techniques with a less severe course and faster recovery . recent advances in instrumental technology including the bipolar electrothermal device, ultrasonic scalpel, and circular stapler are gaining popularity as effective alternatives in hemorrhoidectomy . of these instruments, the ligasure vessel sealing system has been recently introduced as a tool conceived to upgrade the conventional treatment of haemorrhoids. this reduces anal spasm and allows performing a bloodless haemorrhoidectomy with reduced post- operative pain and fast healing . .thus this operation can be recommended as the ideal technique. many trials were performed to compare ligasure hemorrhoidectomy with conventional hemorrhoidectomy, although an overall favorable trend exists toward ligasure, conclusions are not univocal and definitive; this creates some uncertainty, also considering the increasing cost for this disposable device: thus it is essential to keep on experimenting to determine whenever an actual advantage exists.

Eligibility criteria:
inclusion criteria: * all patients with ages between 18 to 70 years with symptomatic grade iii, or iv hemorrhoid who will be operated on at the department of general surgery, assuit university hospital exclusion criteria: * age older than 70 years * patients with grade i and ii haemorrhoids * patients on anticoagulants * patients with liver cirrhosis * patients with the hematological disorder * patients with the concomitant anal disease * patients had previous history of anorectal surgery
study of oral elagolix tablets to assess the tolerability and change in disease symptoms in adult female participants with moderate to severe endometriosis-associated pain

Conditions: Endometriosis

Summary: endometriosis is an abnormal, estrogen-dependent growth of endometrial tissue outside the uterus that frequently results in dysmenorrhea and pelvic pain and often causes infertility. endometriosis is a significant burden on the quality of life of women. this study will assess the tolerability and how effective elagolix is in changing the disease symptoms in adult female participants with endometriosis. elagolix is an approved drug for treatment of endometriosis. adult female participants with a diagnosis of endometriosis, who are prescribed elagolix by their physicians, in accordance with local clinical practice and label will be observed for up to 24 months. around 80 female participants will be enrolled in the study in israel. participants will receive elagolix as prescribed by their physicians. there may be a higher burden for participants in this study compared to standard of care. patients report outcomes, in the form of questionnaires will be collected up to 24 months prospectively to assess the impact of elagolix on quality of life.


Eligibility criteria:
inclusion criteria: * diagnosed with endometriosis and experiencing dysmenorrhea (dys). * naïve to elagolix prior to starting this study or have stopped taking elagolix for 2 months prior to study enrollment. * prescribed elagolix as part of standard treatment for endometriosis, according to the local label. exclusion criteria: * contraindication to the use of elagolix. * post-menopausal (naturally or surgically). * participation in a concurrent interventional clinical trial.

Keywords: elagolix orilissa abt-620 endometriosis
the effect of respiratory muscle training for patients with copd and mild cognitive impairment

Conditions: Chronic Obstructive Pulmonary Disease; Mild Cognitive Impairment

Summary: patients with copd and mci received either inspiratory muscle training or inspiratory plus expiratory muscle training and compared the therapeutic effects

patients with copd and mci were recruited, and were randomly assigned to the experimental group and the control group. the experimental group consisted of emt and imt for a total of 8 weeks, while the control group received imt only. outcomes measured and compared in this cohort were diaphragmatic thickness fraction and excursion examined by ultrasound, the dyspnea score of modified medical research council (mmrc), the cognitive score of mini-mental state examination (mmse), and the score of copd assessment test (cat). in addition, the pulmonary function test, the cardiopulmonary exercise test, and the physiology performance of six minute walking test were also obtained. we also analyzed the difference of each parameters before and after training in each patient.

Eligibility criteria:
inclusion criteria: * 1. having definite diagnosis of copd, namely the value of the fev1 divided by forced vital capacity (fvc) 10 to 15 minutes after beta-2 agonist inhalation being less than 0.7. * 2. the score of mini-mental state examination (mmse) being between 23 and 27 exclusion criteria: * 1. being not able to follow instructions on respiratory muscle training or complete the questionnaires of our study due to cognitive impairment. * 2. having difficulty to complete the cardiopulmonary exercise testing or the six minute walking test (6mwt) due to high risk cardiopulmonary diseases or other orthopedic conditions. * 3. having the diagnosis of lung cancer or history of receiving thoracoabdominal surgery * 4. having body mass index more than 30
prevention of hyperalgesia with epidural morphine

Conditions: Hyperalgesia

Summary: american society of anaesthesiologist physical status (asa) i-iii 105 patients who undergoing major abdominal surgery in obstetric and gynaecology clinic were recruited to this study. patients were randomized into the 3 groups. lumbar epidural catheter will be inserted to the all patients. after than anaesthesia induction will provide with 2 mg/kg propofol and 0.6 mg/kg rocuronium. desflurane and azot protoxit (n2o)-o2 will use for anaesthesia maintenance. during surgical operation, 0.3 microgram/kg/h remifentanil infusion will continuous till the end of surgery. in group i, 2 ml serum physiologic (0.9 nacl)will apply from epidural catheter before surgical incision. in group ii, 1 mg morphine will apply from epidural catheter before surgical incision. in group iii, 1 mg morphine will apply from epidural catheter at the time point of peritoneum is closed. epidural patient controlled analgesia will provide with bupivacaine for postoperative analgesia. postoperative pain will be assessed with numerical pain scale. postoperative analgesic requirement will be calculated. hyperalgesia will detect with algometer and von frey ligaments.

this randomized, double blind, controlled study will perform after obtaining informed consent and ethics approval. american society of anaesthesiologist physical status (asa) i-iii 105 patients who undergoing major abdominal surgery in obstetric and gynaecology clinic were recruited to this study. patients were randomized into the 3 groups with computerized randomization programme. lumbar epidural catheter will be inserted to the all patients. after than anaesthesia induction will provide with 2 mg/kg propofol and 0.6 mg/kg rocuronium. desflurane and n2o-o2 will use for anaesthesia maintenance. during surgical operation, 0.3 microgram/kg/h remifentanil infusion will continuous till the end of surgery. in group i, 2 ml serum physiologic (0.9 nacl)will apply from epidural catheter before surgical incision. in group ii, 1 mg morphine will apply from epidural catheter before surgical incision. in group iii, 1 mg morphine will apply from epidural catheter at the time point of peritoneum is closed. epidural patient controlled analgesia will provide with bupivacaine for postoperative analgesia. postoperative pain will be assessed with numerical pain scale. postoperative analgesic requirement will be calculated. hyperalgesia will detect with algometer and von frey ligaments.

Eligibility criteria:
inclusion criteria: * asa i-iii patients * patients who undergoing major abdominal surgery exclusion criteria: * asa iv and up * coagulopathy
the effect of oral vasopressors for liberation from iv vasopressors in spinal shock

Conditions: Spinal Shock

Summary: the study is developed to evaluate the effect of use of oral vasopressors (midodrine versus minirin) on weaning icu patients from iv vasopressors (noradrenaline) and compare between them for efficacy in shortage the duration of iv vasopressor and has low complications and side effects.


Eligibility criteria:
inclusion criteria: * age of 18 - 60 years. * patients of both genders. * patients diagnosed by spinal shock and they are in the recovery stage . exclusion criteria: * patient refusal. * anuric or oliguric patients or patients with chronic kidney disease. * patients with allergy to medication included in the study.
effect of exercise training on obstructive sleep apnea syndrome severity

Conditions: Sleep Apnea Syndromes; Sleep Apnea, Obstructives

Summary: sleep apnoea affects more than 20% of people over 65 years and is largely underdiagnosed. it does multiply tenfold the occurrence of vascular events, particularly stroke. while continuous positive airway pressure (cpap) is currently the gold standard treatment to prevent cerebrovascular and cardiovascular events, with a major clinical benefit, long term adherence to cpap is a significant problem and search for alternative treatment is essential. the investigators hypothesize that long-term exercise training would allow to reduce significantly sleep apnoea syndrome severity. thus, in this study, the investigators will compare evolution of apnoea hypopnea index (ahi) in an exercise trained group performed through in a national based non-profit organization (fédération française d'éducation physique et de gymnastique volontaire (ffepgv)) using a medical established program (neurogyv) during nine months against a control group receiving only standard dietetic and physical activity counseling.


Eligibility criteria:
inclusion criteria: * patients affiliated or entitled to a social security system * patients with ahi from 15 to 30 per hour * signature of consent exclusion criteria: * patients being already treated for sleep apnea or clinical status (cardiovascular comorbidities) justifying an immediate initiation of cpap * daytime sleepiness (ess score \> 10) * known respiratory or heart disease (or discovering during stress test) contraindicated exercise training * patients with parkinson's disease

Keywords: sleep apnea syndromes sleep apnea, obstructives training
effects of yoga on phase angle and quality of life in patients with breast cancer

Conditions: Breast Cancer

Summary: in this study,we aimed to examine the effects of hatha yoga on pa and qol in patients with breast cancer. patients will be randomized to receive the yoga group and the control group.hatha yoga will be practiced twice a week for 10 weeks for intervention group.the pa of the patients will be assessed using a body analysis instrument and qol was evaluated with an eortc-q questionnaire both before treatment and at week 10.


Eligibility criteria:
inclusion criteria: * patients between the ages of 18 and 70, witha diagnosis of breast cancer exclusion criteria: * patients with recurrent or progressive disease, or with serious heart or pulmonary disease, with uncontrolled hypertension, infection, cognitive function disorder, psychiatric disease or musculoskeletal system conditions that would prevent exercise, and those who had taken part in a regular exercise program

Keywords: phase angle hatha yoga breast cancer quality of life
improving pain management in nursing homes: a pilot study

Conditions: Pain Management

Summary: this study aims to improve pain management in swiss nursing homes by addressing behavior change of the care workers with a multilevel intervention

pain management in nursing homes often is inadequate despite the availability of evidence- based pain management guidelines. barriers to pain management in nursing homes occur on several levels including lack of knowledge and negative beliefs towards pain of care workers. for this embedded mixed-methods pilot study a convenience sample of maximum six nursing homes will be recruited. the planned intervention comprises the implementation of pain management policies, training of all care workers in pain assessment and management as well as training and introduction of a facility pain champion. quantitative outcomes assessed at baseline, after three and six months include self-efficacy and attitudes to pain of care workers, functional interference from pain and pain intensity in residents. feasibility and acceptability of the intervention and potential barriers to its implementation will be explored in focus groups and interviews.

Eligibility criteria:
inclusion criteria: care workers: * registered nurses, licensed practical nurses/certified caregivers, nursing assistants, nurse aides and other care workers from the participating nursing home * working in direct resident care * participating care workers have to be employed for at least one month at the data collection * students, apprentices and interns have to be employed at least six months in total * speak and understand german * older than 16 years residents: * all residents living in a participating nursing home, older than 64 years * written informed consent to participate in data collection signed by the resident or in case of severe cognitive impairment by his/her legally acceptable representative exclusion criteria: care workers: * temporary employment for less than six months residents: * critical current health status or terminal life situation * known life expectancy less than 3 months * short term residents (length of stay \<6 months)

Keywords: nursing home
cerebral palsy: short-burst interval training

Conditions: Cerebral Palsy Spastic Diplegia

Summary: this study examines the effect of short burst interval treadmill training in ambulatory children with cerebral palsy. half the sample will receive 20 sessions of training over 4 weeks, while half will receive the training over 10 weeks.

ambulatory children with cerebral palsy (cp) experience activity limitations which negatively influence their ability to physically participate in day to day life. therefore, these children are at greater risk for inactivity and functional decline with age. in contrast, typically developing (td) children engage in short bursts of intense physical activity interspersed with varying intervals of low and moderate intensity within their natural environment. these physical activity patterns are very different from adult patterns despite these inherent differences, locomotor treadmill training (ltt) protocols designed to improve walking activity in children with cp simulate adult protocols, consisting of continuous low to moderate walking endurance activity. body weight supported or robot assisted ltt is based on the underlying premise of modifying neural circuitry via spinal pathways. however, this type of training has not been shown to be more effective than other comparable interventions and presents with significant fiscal and logistical barriers to clinical translation. this study will determine the effect of short-burst interval ltt without body weight support on the primary outcomes of walking performance and capacity and the secondary outcomes of day-to-day mobility based participation in children with cp with functional walking limitations. to identify key muscular mechanisms associated with improved walking mobility, the investigators will examine the effects of short-burst interval ltt on quadriceps muscle performance and architecture. secondarily, the study team will collect preliminary data on two ltt dosing frequencies.

Eligibility criteria:
inclusion criteria: * ambulatory children with cerebral palsy spasticity primary movement disorder bilateral motor impairment (diplegia) gross motor function classification system levels ii and iii exclusion criteria: * undergone orthopedic or neurosurgery less than 12 months prior injection therapies (phenol, botulinum toxin) less than 3 months prior
cognitive dysfunction in copd patients : role in the performance of cognitive-motor dual task situation?

Conditions: Chronic Obstructive Pulmonary Disease

Summary: chronic obstructive pulmonary disease (copd) is a respiratory disease starting point characterized by multiple systemic effects as cognitive dysfunction. this one seems to have an impact in activity daily living, considered mainly as a cognitive-motor dual task situations. yet to date, no study has specifically focused in the cognitive-motor performance in patients with copd or on the effects during a rehabilitation program. the main objective of this work was to evaluate the impact of cognitive dysfunction in copd, comparing performance between copd patients and healthy subjects in a single and dual task cognitive-motor situation. the secondary objective was to assess the impact of a rehabilitation program on these performances.


Eligibility criteria:
inclusion criteria: * male or female about 40 to 80 years old * copd patient (tiffeneau \ 15h/day) * written and informed consent of the subject * authorization to physical activity referring doctor in the clinic * comorbidities no dominating exclusion criteria: * subject with neurological pathology, cognitive or psychiatric * subject with pain and / or plantar injuries * subject has a prosthetic knee and / or hip. * subject requiring walking aid (cane, walker, etc.)

Keywords: cognitive dysfunction activity of daily living interference rehabilitation cognitive-motor dual task
evaluation of the response to monoclonal antibody therapy in severe asthma: research of predictive biomarkers in exhaled air

Conditions: Asthma

Summary: this study evaluates the change in the composition of volatil organic compounds (voc) in patients treated by monoclonal antibody for severe asthma.

at least one in two patients treated by monoclonal antibody for severe asthma doesn't have satisfying result after 6 months of treatment. the evaluation of the answer, and even better the answer prediction, are fundamental issues for medico-economic plan as part of these innovative therapeutics. the interest of the use of voc as diagnostic or prognostic tool in patients with tumoral thoracic pathology or bronchial or pulmonary vascular diseases has been demonstrated. voc analysis will be performed using two different techniques: electronic nose and masse spectrometry. at each visit, in addition to the usual assessment, patients will have two non-invasives collections of exhaled air, one for electronic nose analysis and one for masse spectrometry analysis.

Eligibility criteria:
inclusion criteria: * patient aged \> 18 years old * patient with severe asthma who respond to the indication of monoclonal antibody therapy according to spc and management criteria fixed by transparency committee * signed informed consent * patient with healthcare insurance exclusion criteria: * patient not responding to the criteria for the good use of monoclonal antibody in severe asthma * contraindication to one of monoclonal antibody treatment according to spc (hypersensitivity to one of compounds) * patient unable to perform a slow vital capacity * patient with long-term oxygen therapy , under invasive ventilation * pregnant women * patient deprived of liberty by judicial or administrative decision
hemostasis in sickle cell disease--infancy to adulthood

Conditions: Anemia, Sickle Cell; Blood Disease

Summary: to assess in older children and adults with sickle cell disease (scd) whether intrinsic activation (relevant to the origin of pain and acute inflammation) occurs only during vasocclusive crisis (voc).

background: investigations into hemostatic abnormalities associated with sickle cell disease have been numerous. the data suggested that thrombin generation and fibrin formation were increased during steady state, with conflicting data whether further activation occurred in vaso-occlusive crisis. platelet activation during voc occurred, with variable findings during steady state. a selective, concomitant evaluation of the hemostatic pathways i.e. intrinsic, tissue factor (tf) or extrinsic activation, fibrinolysis, and platelet-endothelial activation had not been reported. neither had a longitudinal evaluation been performed in infants during the unique transition period when hbf levels fall from 70 to 80 percent to less than 10 percent. the study was part of an initiative on "coagulation, platelets and thrombosis in sickle disease pathophysiology". the request for applications was released in october 1994. design narrative: the studies used appropriate 'negative' and 'positive' control groups. studies included intrinsic markers \[kininogen profiling, high molecular weight kininogen (hk) and low molecular weight kininogen (lk) cleavages, western blotting of hk and lk, and kallikrein-alpha2 macroglobulin; extrinsic markers \[tf and factor v11a\]; other activation and fibrinolytic markers \[prothrombin f1.2, fpa, tat, tpa, pai-i, d-dimer and plasma alpha2 antiplasmin\]; platelet- endothelial markers \[evaluation of activation dependent epitopes\]. unequivocal demonstration of contact pathway activation during voc provided a crucial link between voc and its accompanying phenomenon including pain, and inflammation. finally, the studies provided a unique perspective on the continuum of hemostatic changes that unfolded during the course of scd, and those that developed as vascular insufficiencies supervened in the adult. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria