Kornimate/medical-research-clean huggingface dataset:
preliminary tissue monitoring during endovascular intervention study

Conditions: Peripheral Arterial Disease; Peripheral Artery Disease; Arterial Occlusive Diseases

Summary: tissue perfusion assessment is key to more accurate measurement of foot ischemia, which is in turn an important factor in appropriate treatment decisions. in practice though, tissue perfusion measurements are not routinely undertaken as few practical solutions exist that are easy to use and fit in everyday clinical practice. pedra has developed a novel easy to use, non-invasive device that can be used in practice to better inform treatment decisions.

tissue perfusion assessment is key to more accurate measurement of foot ischemia, which is in turn an important factor in appropriate treatment decisions. in practice though, tissue perfusion measurements are not routinely undertaken as few practical solutions exist that are easy to use and fit in everyday clinical practice. pedra has developed a novel, easy to use, non-invasive device that can be used in practice to better inform treatment decisions. this is a feasibility study to demonstrate the ability of the xauron system to track tissue perfusion changes in patients undergoing endovascular intervention for the treatment of peripheral artery disease (pad). the findings of this study are for research purposes and will also be used to help with the future education of physicians about the potential use of the xauron system. in addition, this early pilot data will be used to help power larger, more definitive studies relating to the intra-procedural use of the xauron system.

Eligibility criteria:
inclusion criteria: 1. the subject is undergoing endovascular intervention for the management of their pad. 2. the subject is between 40 to 90 years of age. 3. documented lower limb arterial occlusive or stenotic disease (using ankle-brachial index / pulse volume recording, duplex ultrasound or ct angiogram) within the last 8 weeks. 4. in the opinion of the investigator, the subject is willing and able to comply with the protocol and complete all protocol assessments. 5. the subject has been informed of the nature of the study, agrees to its provisions and has willingly provided written informed consent, approved by the appropriate institutional review board (irb) exclusion criteria: 1. subjects on an investigational drug or being treated with an investigational therapeutic device, within 30 days of the study visit, that in the view of the investigator might interfere with the study outcomes. 2. presence of a condition that the investigator considers will compromise the subject's ability to participate in the study. 3. subjects on renal replacement therapy 4. signs of active infection causing localized inflammation on the plantar or dorsal surfaces of the foot. 5. lack of intact skin, or pathological skin conditions, at the proposed sensor pad positions that may impair or prevent the adherence of medical adhesives in general. 6. diabetic subjects with a charcot neuropathic osteoarthropathy
possibilities of use mri-guided laser interstitial thermal therapy in medically intractable tremor

Conditions: Laser Interstitial Thermal Therapy; Parkinson Disease; Essential Tremor; Movement Disorders; MRI

Summary: medically intractable tremors are a common difﬁcult clinical situation. deep brain stimulation decreases parkinson's disease tremor and essential tremor, but not all patients are candidates from a diagnostic, medical, or social standpoint, prompting the need for alternative surgical strategies. less invasive lesional brain surgery (thalamotomy) procedures by radio-surgery or mri-guided focused ultrasound have emerged and have proven to be effective in these third-line indications. recently, a new technology has emerged allowing the performance of minimally invasive lesion surgeries by mri-guided laser interstitial thermal therapy (mrig-litt). mrig-litt has been shown to be effective and safe in management of epilepsies and brain tumors. however, no study has evaluated mrig-litt for performing thalamotomy in medically intractable tremor.in a pilot study, the investigators propose to evaluate the effect and safety of unilateral thalamotomy by mrig-litt in the management of medically intractable tremor of parkinsonian or essential origin.


Eligibility criteria:
inclusion criteria: * patients 18 years age or older with parkinson\&#39;s disease or essential tremor and tremor resistant to medical therapy with a contraindication to deep brain stimulation or refusal deep brain stimulation exclusion criteria: * contraindication to mri * contraindication to general anesthesia * patient unable to give their free and informed consent because of cognitive or psychiatric disorders * brain anatomical abnormalities not allowing intervention * adults protected (guardianship, curators) or deprived of liberty.

Keywords: laser interstitial thermal therapy parkinson disease essential tremor movement disorders mri
effect of lidocaine infusion on neuraxial opioid-induced pruritus after cesarean section

Conditions: Lidocaine Infusion; Neuraxial Opioid; Pruritus; Cesarean Section

Summary: the aim of this study is to assess the efficacy and potency of lidocaine infusion as a preventive measure on pruritus response after injection of 200 micro gram morphine with bupivacaine subarachnoid block, spinal anesthesia, in cesarean section.

neuraxial opioids (no) are one of the most widely used methods for postpartum analgesia, for cesarean section analgesia, and many other surgical procedures. the pruritus induced by no is an unpleasant, subjective, and irritating sensation that causes scratching response. pruritus begins shortly after anesthesia, with the onset depending on the type, route and dosage of opioid used. pruritus invoked by lipid-soluble opioids such as fentanyl and sufentanil is of shorter duration, and the use of the minimum or small dose from opioids in addition of local anesthetics seems to decrease the prevalence and the severity of itching. pruritus invoked by intrathecal morphine is of longer duration and is difficult to treat. intrathecal administration, of opioids reach peak concentrations in the cerebrospinal fluid almost immediately. \]. but, after epidural administration, there is a delay in the rise to peak concentration (10-20 min with fentanyl and 1-4 h with morphine).

Eligibility criteria:
inclusion criteria: * age from 20 to 40 years. * weight from 50 to 90 kg. * women undergoing cesarean section. exclusion criteria: * patient with known allergies to lidocaine. * preexisting pruritus. * coexisting skin disorders. * contraindications to spinal anesthesia. * preeclampsia. * eclampsia. * major systemic diseases. * refusal to participate. * uses of any current drugs have potential effects on post-operative itching as steroidal ,nonsteroidal ,ondanstern, propofol, midazolam during study period.
preemptive oral gabapentin and tramadol on postoperative pain after knee arthroscopy

Conditions: Gabapentin; Tramadol; Postoperative Pain; Knee Arthroscopy; Spinal Anesthesia

Summary: the aim of this study to evaluate the effect of preemptive oral gabapentin versus tramadol on postoperative pain after knee arthroscopy under spinal anesthesia.

orthopedic surgeries are frequently associated with moderate-to-severe postoperative pain that can decrease mobility in the immediate postoperative period, interfere with postoperative rehabilitation, and delay hospital discharge. pain may also become chronic. spinal anesthesia is the most popular anesthesia technique worldwide in orthopedic lower limb surgeries. however, its relatively short duration of action may limit the excellent postoperative analgesic effect. thus, many adjuvants had been used to improve postoperative analgesia and decrease consumption of postoperative analgesics. gabapentin is a gamma aminobutyric acid analogue that is known as an anticonvulsant drug. this drug is tolerated well and has known effects on pain and anxiety. tramadol, a commonly used postoperative analgesic, is a synthetic centrally acting opioid analgesic. the various actions include inhibition of noradrenaline and serotonin reuptake, and also inhibition of m1 and m3 muscarinic receptors

Eligibility criteria:
inclusion criteria: * age 18-65 years old. * both sexes. american society of anesthesiologists (asa) physical status i and ii * undergoing knee arthroscopy procedures. * under spinal anesthesia. exclusion criteria: * cardiac patients. * patients with known allergy to drug of study. * prolonged administration of nsaids or other analgesics due to chronic pain of any reason. * cirrhosis.
the effect of pelvic floor muscle training with stabilization exercises with various intensity in women with stress urinary incontinence

Conditions: Stress Urinary Incontinence

Summary: this study will evaluate the safety, tolerability and efficacy of high- and low-intensity pfmt with stabilization exercises in women with sui

this is a randomized interventional parallel study to evaluate the effect of pfmt with stabilization exercises of high and low intensity in women with sui

Eligibility criteria:
inclusion criteria: 1. willing to provide written informed consent 2. over 18 years old and experiencing uncomplicated sui 3. score on the international consultation on urinary incontinence questionnaire of ≥ 6 points 4. symptoms of urinary incontinence for at least three consecutive months 5. degree of pelvic organ prolapse, stage ≤ 2 6. willingness to accept the randomization process and fully participate in tests exclusion criteria: 1. history of anti-incontinence surgery in the past 12 months 2. history of pelvic prolapse repair or urethral surgery in the past 12 months 3. history of pfmt in the past 12 months 4. history of interstitial cystitis or bladder-related pain 5. chronic severe constipation 6. clinically significant renal or hepatic impairment 7. clinically significant heart impairment 8. pregnant, lactating or actively trying to become pregnant 9. positive urinary tract infection 10. use of rehabilitation aids (pessaries, urethral plugs, vaginal beads, etc.) 11. insufficient understanding of pelvic floor exercises and/or omitting exercises 12. incomplete questionnaire 13. refusal to participate in the study

Keywords: stress urinary incontinence; 2d/3d ultrasound pelvic floor muscle training
therapeutic effect of shoulder anterior capsular block versus suprascapular nerve block in patients with frozen shoulder

Conditions: Frozen Shoulder

Summary: he study will include 50 patients with frozen shoulder with no healthy volunteer , patients in this study will be randomized into two groups suprascapular nerve block and shoulder anterior capsular block

the study will include 50 patients with frozen shoulder with no healthy volunteer , patients in this study will be randomized into two groups according to the treatment performed . shoulder anterior capsular block group description: ultrasound guided injection for the shac block, with the patient in a beach-chair position and with the arm in extension, the subscapularis muscle is stretched posteriorly and becomes easily visible. with external rotation and abduction, the coracobrachialis and the biceps brachii muscles are displaced, allowing the visualization of the interfascial space between the deep lamina of the deltoid muscle fascia and the superficial lamina of the subscapularis fascia.once the injection into the fascial space is achieved, the investigators can proceed towards the glenohumeral pericapsular space by crossing the subscapularis muscle with the needle. by injecting the pericapsular space, the investigators reach the terminal articular branches indistinctly from their origin. furthermore, through the weitbrecht foramen, a natural capsular foramen between the upper and middle glenohumeral ligaments, we also reach the intra-articular space . suprascapular nerve block group description: patients will be placed in lateral position by using a high - frequency linear ultrasound probe will be placed approximately 2 cm medial to the medial border of the acromion and about 2 cm cranial to the superior margin of the scapular spine the needle will be inserted .the tip of the needle will be placed at the floor of the supraspinatus fossa where the nerve has passed * a volume of (10ml) of 2% lidocaine (2ml), 3% mepivacaine (2ml) , 1 ml methyl-prednisolone acetate (40 mg) and dextrose 5% (5ml) will be injected to both groups. * all patients in both groups will receive immediate stretching exercises and post injection 3 times weekly followed by home exercises

Eligibility criteria:
inclusion criteria: * age above 18 years. * both sexes, males and females. * history of complaint \>6 weeks * restricted shoulder movement unilaterally in at least 2 planes including abduction, external rotation, and internal rotation and restricted passive movement. exclusion criteria: * patient refusal. * -allergy to local anaesthetics. * -infection at the site of injection . * -coagulopathy * -prolonged opioid medication * -pregnancy * -acute trauma, fracture of the shoulder * people who had received an intra-articular shoulder injection within the last 6 months. * patients with tendon tear
liberalization of visiting policies in icu for reducing high risk of post-traumatic stress disorder

Conditions: PTSD in Family Members of ICU Patients

Summary: this was a cluster randomized study of an icu level intervention to reduce high risk of post-traumatic stress disorder (ptsd) in family members of icu patients. participating icus had restrictive visiting policies (i.e., \<6 hours/day) before randomization. after an observational period and a washout period, participating icus were randomized either to maintain their visiting policies or to liberalize their visiting policies (24 hours a day, 7 days a week.)

family members of icu patients are particularly exposed to anxiety, depressive, acute stress disorder, and posttraumatic stress disorder symptoms (ptsd). it is currently unknown what type of interventions/ strategies to cope with postintensive care syndrome family would produce the best improvement. experts suggest that symptoms in family members are potentially amenable to intervention by icu staff. one intervention to reduce ptsd could be a liberalization of the visiting hours. however, restrictions on visiting hours in the intensive care unit (icu) are usually adopted worldwide.

Eligibility criteria:
inclusion criteria : patient and family member \> 18 years or older, * mechanical ventilation expected for more than 48 h and inclusion between day 3 and 5 from the beginning of mechanical ventilation, * patient having a family member speaking and understanding french, and with the ability to visit his/her relative during the icu stay, * patient and his/her relative consenting to participate in the study, or obtention of family consent in case of patient incompetency exclusion criteria : - patient without family available or family not speaking or understanding french"

Keywords: posttraumatic stress disorder (ptsd) icu visiting hours policies
extensively diseased left anterior descending coronary artery: on pump vs off pump cabg?

Conditions: CAD - Coronary Artery Disease

Summary: diseased left anterior descending coronary artery (lad) is one of the most challenging conditions in bypass surgery. we investigate whether on-pump coronary artery bypass grafting (cabg) is more beneficial in those critical patients or off-pump surgery.


Eligibility criteria:
inclusion criteria: * any patient with diffuse lad disease indicated for open heart surgery exclusion criteria: * no concomitant valve disease * any patient can be treated by medical treatment or pci

Keywords: on-pump off-pump cabg lad
metabolic response to beverages with various sweetening systems consumed during meal in overweight and obese subjects

Conditions: Overweight and Obesity

Summary: the purpose of this clinical study is to investigate the effect of drinking a sugar-sweetened beverage along with a meal on insulin concentrations and, glucose and lipid metabolism, in overweight and obese subjects, during a 10-hour visit.


Eligibility criteria:
inclusion criteria: * subject, upon briefing of the content of the present study, fully understanding and agreeing to its objective and having given written (dated and signed) informed consent form to take part in the study * subject who is able to communicate well with the investigator and to comply with the requirements of the entire study * if of child bearing potential, female subject must be using or complying with one of the following medically approved methods of contraception such as, but not exclusively: oral birth control pills (at least 1 full monthly cycle prior to study product administration); intra-uterine device (iud); double barrier methods (such as condoms and spermicide) * subject with a body mass index (bmi) between 25 and 35 kg/m² inclusive exclusion criteria: * pregnant woman, based on positive urine pregnancy test, or planning to become pregnant during the study or breast-feeding woman * surgical operation on digestive tract, except appendectomy * subject who had any surgery or intervention requiring a general anaesthesia in the preceding 4 weeks, or who plans to have one during the course of the study * subject with diagnosed or suspected allergy or hypersensitivity to any food ingredient, including components of the study products (ingredients of sugar-sweetened beverages) * blood donation within the last 3 months or planning to give blood during the course of the study * subject involved in any other clinical study within the preceding month or in the exclusion period after another clinical study * subject in a situation, which in the investigator's opinion could interfere with optimal participation in the present study or could constitute a special risk for the subject * evidence of clinically relevant cardiovascular, metabolic, hematologic, hepatic, gastrointestinal, renal, pulmonary, endocrine or psychiatric history of disease as determined by medical history, physical examination, and vital signs * clinically significant abnormal results for urine or blood analyses

Keywords: sugar-sweetened beverage overweight obese sugar water
tdcs versus tsdcs for endometriosis-related chronic pelvic pain treatment

Conditions: Endometriosis; Pelvic Pain; Transcranial Direct Current Stimulation; Spinal Cord Stimulation

Summary: the purpose of the study is to compare the analgesic effect of 2 ma anodal direct current stimulation on the right primary motor cortex (m1) (tdcs) with a similar stimulation on the spine (d10) (tsdcs) in healthy volunteers (hv) followed by a pilot study in patients suffering of endometriosis-related chronic pelvic pain (cpp)

- 2 groups of 5 hv will receive tdcs or tsdcs (2ma, anodal, 20min) and the thermonociceptive threshold will be measured before and after the stimulation over the abdomen (hypogastric). the had scale and sf-36 will also be tested. the treatment(s) that produces the greatest increase in pain thresholds will be chosen to treat 10 patients. - 10 patients suffering from endometriosis-related chronic pelvic pain will be treated by the most efficient treatment (tdcs or tsdcs) for 4 weeks (5 daily 20-min sessions per week), or, if no treatment modality was superior in hv, 5 patients will be treated by tdcs and 5 by tsdcs. patients will fill in daily a dedicated diary 2 weeks before treatment, during the4-week treatment period and after this period as long as their pain level remains below 80% of their baseline pain intensity (vas). analgesic intake will also be monitored as well as had and sf-36 scores.

Eligibility criteria:
inclusion criteria: * hv: good health. * cpp patients: surgical diagnosis of endometriosis within the last 10 years; diagnosis of chronic pelvic pain (according to acog); mean vas pain score \>4 during severe episodes. exclusion criteria: * hv: chronic pain disorder; no regular medication or illicit drug use. * cpp patients: pregnancy; other medical or psychiatric condition interfering with pelvic pain assessment.
ehealth based self-management intervention for chronic kidney disease care in china

Conditions: Chronic Kidney Diseases

Summary: the purpose of this study is to develop an evidence-based tailored ehealth self-management intervention for patients with chronic kidney disease in china, and test the impact on implementation and effectiveness of interventions.

interventions that support disease self-management (further referred to as 'self-management interventions') can have a significant impact on the health and quality of life of patients suffering from chronic conditions in general and chronic kidney disease (ckd) patients in specific. in the last decade, the use of electronic health (ehealth) technology in self-management interventions has become more and more popular. ehealth-based self-management interventions have been shown to improve health-related outcomes, such as blood pressure (bp) control and medication adherence, and found to be feasible and acceptable for ckd patients and care professionals. hence, the use of ehealth self-management interventions for ckd patients has become increasingly popular. knowledge of the implementation and effectivity of such interventions in china and other developing countries is, however, still lacking. researchers from the leiden university medical center (lumc) developed 'medical dashboard', an ehealth intervention to help support and involve ckd patients in their disease self-management. we aim to tailor the evidence-based dutch intervention 'medical dashboard' to the chinese context and evaluate its implementation process and effectiveness.

Eligibility criteria:
inclusion criteria: * patients: (1) aged over 18 years old; (2) diagnosis of chronic kidney disease; (3) chinese speaking. * health care providers who work in the department of nephrology exclusion criteria: * individuals unable to participate due to physical or mental disabilities. * individuals unable to write or read.

Keywords: ehealth self-management chronic kidney disease