Kornimate/medical-research-clean huggingface dataset:
cpap for esophageal cancer with radiotherapy

Conditions: Esophageal Cancer

Summary: the goal of this clinical trial is to test the use of cpap in patients with esophgaeal cancer undergoing radiotherapy. the main questions it aims to answer are: * does use of cpap decrease exposure of normal lung to radiation? * does use of cpap decrease exposure of normal heart to radiation? participants will undergo simulation twice: * with cpap * without cpap


Eligibility criteria:
inclusion criteria: 1. diagnosis of cancer, with a tumor (primary or secondary) in the esophagus including tumors in the esophagus-stomach junction. 2. age ≥ 18 3. planned rt treatment 4. the level of functioning ≥ 60 on the karnofsky scale 5. life expectancy ≥ two months 6. all patients must understand the informed consent form document and sign it of their own free will before any test/procedure related to the study is performed. 7. able to undergo simulation and radiation with cpap 8. candidate patients can be recruited to receive definitive, palliative or pre-operative radiation, with or without chemotherapy. exclusion criteria: a person who meets any of the following exclusion criteria will not be able to participate in the study: 1. pregnancy or breastfeeding 2. significant comorbidity at the starting point that would prevent the use of cpap 3. hospitalized in an institution by virtue of an administrative order or a court order. 4. special population 5. a history of a psychiatric problem that may impair the patient's ability to understand the research requirements or respond to them, or to give his consent

Keywords: radiation
preoperative inspiratory muscle training effects on the perioperative inflammatory reaction in cardiac surgery.

Conditions: Thoracic Surgery; Prehabilitation; Respiratory Therapy

Summary: this study evaluates the impact of preoperative high-intensity inspiratory muscle training (imthi) before cardiac surgery on perioperative inflammatory response. half participants will receive high intensity inspiratory muscle training and the others a sham inspiratory muscle therapy.


Eligibility criteria:
inclusion criteria: * waiting for thoracic surgery with valve replacement * preoperative surgeon consultation between 3 and 6 weeks before surgery exclusion criteria: * patient with antecedent of lung surgery * patient with neuromuscular or neurovascular disease * non anticipated surgery with a time between surgeon consultation and surgery inferior to 3 weeks. * inhability to do the preoperative exercises

Keywords: inspiratory muscle training systemic inflammatory response syndrome
the effect of the free-toroidal design lenses on the subjective visual quality in the myopic population

Conditions: Myopia; Refractive Errors

Summary: a prospective, self-control, double-blind design was conducted in tianjin. two hundred participants were assigned to wear two kinds of spectacle glasses. to examine the effect of free-toroidal design and aspherical lens on the subjective visual quality among the myopic population.

a prospective, self-control, double-blind design was conducted in tianjin. two hundred participants were assigned to wear two kinds of spectacle glasses. to examine the effect of free-toroidal design and aspherical lens on the subjective visual quality among the myopic population. the subjective visual quality of clarity and comfort were determined using a questionnaire when first wearing the glasses and after 1week.

Eligibility criteria:
inclusion criteria: * health volunteers * their spherical refraction from -0.50 to -8.00 diopter, with the cylinder diopter less than -3.00 diopter * best corrected visual acuity (bcva)≥ 20/20 in both eyes * stable refraction (no change greater than 0.5 diopter within two years) exclusion criteria: * if they had aphakic or intraocular lens eyes, had a history of trauma, active eye disease or ocular surgery, serious systemic diseases, or had a wearing history of corneal contact lenses.
low-fiber diet for colorectal cancer screening colonoscopy

Conditions: Colonic Diseases

Summary: this trial will compare the efficacy of 2 different sets of dietary recommendations to be followed before colon cleansing for colorectal cancer screening colonoscopy.

there is no enough evidence in the literature to recommend a low-fiber diet for screening colonoscopy. although evidence of benefit of a liquid diet is minimal and there is a growing body of evidence about the benefits of a liberalized diet, a high degree of heterogeneity in the clinical trials comparing the diet modifications before colonoscopy prevents a formal recommendation in current guidelines. a low-fiber diet the day before colonoscopy may result in same efficacy of bowel cleanliness, with an improved tolerability and acceptability. all consecutive patients of a population-based colorectal screening cancer program referred for a colonoscopy will be invited to participate in the study. after obtaining informed consent, they will be randomized to one of the groups: liquid diet or low-fiber diet. the will be interviewed by a registered research nurse, and they will be provided with written instructions for bowel preparation and questionnaires for registering the data of the study. the day of the colonoscopy, questionnaires will be collected and endoscopists blinded for the study bowel preparation will perform the colonoscopy. patients will be contacted for adverse events and a general satisfaction questionnaire, 3 days after colonoscopy.

Eligibility criteria:
inclusion criteria: * consecutive patients referred for a colonoscopy in a population-based colorectal screening program. exclusion criteria: * unwillingness to participate. * inability to follow instructions * active inflammatory bowel disease * incomplete colonoscopies for technical reasons or contraindication as evaluated by the endoscopist

Keywords: colonoscopy diet polyethylene glycols efficacy personal satisfaction colorectal cancer screening
comparison of laser treatment with clobetasol therapy in patients with lichen sclerosus

Conditions: Lichen Sclerosus

Summary: with this trial the investigators look for the effect of laser maintenance therapy in patients with vulvar lichen sclerosus compared to the maintenance standard treatment clobetasol propionate.

vulvar lichen sclerosus (vls) is a chronic inflammatory cutaneous disorder, which can lead to scarring, impaired sexual function and malignancy. gold standard treatment is topical corticosteroids (tcs) initially daily for 12 weeks. to avoid new flourishing of the disease a life-long maintenance treatment 2x/week is later recommended. fractional co2-laser has shown a positive effect on vulvovaginal skin quality with improvement of urogenital atrophy and also lichen sclerosus. this randomised trial compares efficacy of laser treatment to tcs maintenance as well as the duration of the laser effect.

Eligibility criteria:
inclusion criteria: * pre- or postmenopausal * 12 weeks of continuous topical clobetasol treatment completed. * written informed consent * german speaking (study information and ic available only in german) exclusion criteria: * contraindication and limitations for the use of mona lisa glide-laser as described in the instructions for use * contraindication for the use of topic clobetasol * history of vulva laser * immune-suppression * pregnancy or planned pregnancy, breast feeding. * clinically significant concomitant diseases states as severe renal failure, hepatic dysfunction, severe cardiovascular disease, cancer. * history of vulvar or pelvic radiation therapy * uncertain vulvar findings, which require a biopsy. * acute vulvitis, especially recurrent genital herpes * history of vaginal mesh implantation within 6 months preceding this study * known or suspected non-compliance, drug or alcohol abuse * inability to follow the procedures of the investigation, e.g. due to language problems, psychological disorders, dementia, etc. of the subject * participation in another investigation with an investigational drug or another md within the 30 days preceding and during the present investigation * previous enrolment into the current investigation * enrolment of the pi, his/her family members, employees and other dependent persons
mesenchymal stem cells for the treatment of various chronic and acute conditions

Conditions: Autoimmune Diseases; Cardiovascular Disorders; Diabetes Complications; Integumentary Disease; Musculoskeletal Disorders; Neurodegenerative Disorders; Neurologic Disorders; Pulmonary Disorders; Sexual Dysfunction; Urologic Disorders; Viral Illness

Summary: this multi-arm, multi-site study investigates the safety, tolerability, and efficacy of stem cell therapy for the treatment of various acute and chronic conditions. clinically observed initial findings and an extensive body of research indicate regenerative treatments are both safe and effective for the treatment of multiple conditions.

this multi-arm, multi-site study investigates the safety, tolerability, and efficacy of stem cell therapy for the treatment of various acute and chronic conditions. clinically observed initial findings and an extensive body of research indicate regenerative treatments are both safe and effective for the treatment of multiple conditions. this study investigates clinical outcomes of treatments for numerous indications including: autoimmune, cardiovascular, diabetes, integumentary, neurologic / neurodegenerative, pulmonary, orthopedic diseases, sexual dysfunction, urologic disorders and viral illnesses. our hypotheses posit that regenerative treatments are both safe and statistically beneficial for a range of conditions. outcomes will be determined by multiple valid outcome instruments that measure general quality of life information along with condition-specific information.

Eligibility criteria:
inclusion criteria: * age 18 and older * ability to provide informed consent * availability for follow up visits exclusion criteria: * active or recent malignancy (within last 2 years) * pregnancy or breast-feeding * inability to provide informed consent

Keywords: stem cell therapy umbilical cord stem cells amniotic stem cells stem cells msc mesenchymal stem cell medicinal signaling cell erectile dysfunction heart diseases mental disorders neurocognitive disorders neurodegenerative diseases central nervous system diseases tauopathies brain diseases dementia disease cardiomyopathies urologic diseases peripheral nervous system diseases nervous system diseases alzheimer disease musculoskeletal diseases cardiovascular diseases immune system diseases neuromuscular diseases covid-19
trunk position sense, postural stability and spinal posture in fibromyalgia

Conditions: Fibromyalgia; Postural Lordosis; Postural Kyphosis; Proprioception; Postural Stability; Balance

Summary: this study aims to investigate trunk position sense, postural stability and spine posture in fibromyalgia patients and healthy women.


Eligibility criteria:
inclusion criteria: * being women * having fms * being volunteer exclusion criteria: * have neurologic, infectious, endocrine, and other severe psychological disorders * malignancy, * being pregnant * any condition interfering with evaluation (advanced cardiac respiratory or orthopedic problems) * spinal deformities such as scoliosis, spine surgery * inflammatory rheumatic diseases
volumetric changes in large cystic lesions using active decompression and distraction sugosteogenesis vs passive decompression

Conditions: Odontogenic Cysts

Summary: null hypothesis active decompression and distraction sugosteogenesis is not faster than passive decompression in volume reduction of large cystic lesions


Eligibility criteria:
inclusion criteria: * any patient with large cystic lesion exclusion criteria: * any patient can't follow home instructions
cervical preparation in hysteroscopy

Conditions: GYN Disorders

Summary: the hysteroscopy was performed in the proliferativephase of the menstrual cycle. the patients were given generalintravenous anesthesia (propofol/fentanyl) after the vulvar and the vaginal area had been disinfected with a 7.5% betadinesolution by the surgical nurse all operations were performed by the same surgeon to avoid possible discrepancies between different surgeons.

astandard rigid30 hysteroscope (karl storz bettocchi hysteroscope) with a 30° viewing angleand an outer sheath diameter 5.5 mm, inner sheath diameter 4.3 mm and scope diameter 2.9 mmwas used in all procedures. a speculum was introduced into the vagina, and the uterine cervixwas visualized. initially, the surgeon attempted to passthrough the cervical canal with the tool directly. when thatwas not possible or when the cervical canal was too rigid ortoo tight, the cervix was grasped with a tenaculum.

Eligibility criteria:
inclusion criteria: 1. patients of reproductive age 2. have undergone a cesarean section at least once 3. an indication for diagnostic hysteroscopy for menstrualproblems or suspected intrauterine lesions (suchas uterine polyps and ﬁlling defects in the uterine cavity) by abnormal ﬁndings from hysterosalpingography,ultrasonography, or saline infusion sonography. exclusion criteria: 1. patients who delivered vaginally 2. had undergone any other transcervical or transabdominal uterine and cervical intervention other than cesareansection, such as loop electrosurgical procedures, cervical cryotherapy, cervical biopsies, and spontaneousabortions, previous dilation, and previous electiveabortions. 3. patients with cervical pathology,e.g. tears or polyps. 4. the patients with a contraindicationto prostaglandins such as hypersensitivity, bronchial asthma, glaucoma, severeasthma, cardiac, liver or kidney diseases. -
comparison study of mdx-010 (ctla-4) alone and combined with dtic in the treatment of metastatic melanoma

Conditions: Melanoma

Summary: the objectives of this study are to determine the safety and activity profile of multiple doses of mdx-010, and to determine the whether the addition of cytotoxic chemotherapy (decarbazine \[dtic\]) can augment the effects of mdx-010 in patients with chemotherapy naïve metastatic melanoma with a tolerable toxicity profile.


Eligibility criteria:
inclusion criteria * clinical diagnosis of unresectable metastatic melanoma. * no prior chemotherapy for melanoma, and no chemotherapy for other malignancies within 5 years and at least 4 weeks since treatment (surgery, radiation, or immunotherapy) for melanoma. exclusion criteria patients who exhibit any of the following conditions at screening will not be eligible for admission into the study: * any other prior malignancy, except for the following: adequately treated basal or squamous cell skin cancer or superficial bladder cancer, or any other cancer from which the patient has been disease-free for \>=5 years. * active autoimmune disease. * active infection requiring therapy, or chronic active hbv or hcv, or confirmed reactivity with hiv tests.
collecting ducts carcinoma: in depth exploration and biologically driven therapy (cicerone)

Conditions: Collecting Duct Carcinoma

Summary: * collect a large number of samples with certain / suspected diagnosis of collecting duct carcinoma in order to confirm the diagnosis (centralized review) and standardize according to who 2016 criteria * build an extensive tissue bank (dna and rna extraction) aimed at defining the molecular taxonomy of the tumor through 1) transcriptomic analysis 2) gene expression profile * define specific molecular signatures


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * signature of consent (for patients enrolled in the prospective part of the study) * histological diagnosis of renal cell carcinoma of the bellini collecting duct rcc exclusion criteria: -
ai prediction model and risk stratification for lung metastasis in colorectal cancer

Conditions: Colorectal Cancer; Lung Metastases

Summary: background: to assist clinicians with diagnosis and optimal treatment decision-making, we attempted to develop and validate an artificial intelligence prediction model for lung metastasis (lm) in colorectal cancer (crc) patients. method: the clinicopathological characteristics of 46037 crc patients from the surveillance, epidemiology, and end results (seer) database and 2779 crc patients from a multi-center external validation set were collected retrospectively. after feature selection by univariate and multivariate analyses, six machine learning (ml) models, including logistic regression, k-nearest neighbor, support vector machine, decision tree, random forest, and balanced random forest (brf), were developed and validated for the lm prediction. the optimization model with best performance was compared to the clinical predictor. in addition, stratified lm patients by risk score were utilized for survival analysis.


Eligibility criteria:
inclusion criteria: * patients with pathologic confirmation of a primary crc diagnosis exclusion criteria: * (1) patients with multiple primary cancers or other malignancies; (2) patients identified via autopsy or death certificate; and (3) patients with uncertain clinical data values
incisional hernia outcomes study using parietex composite mesh

Conditions: Incisional Hernia

Summary: the purpose of this study is to describe the outcomes of laparoscopic incisional hernia repair surgery and to record the outcomes of patients after surgery.

for subjects who agree to participate in this study, participation will last for 1 year. subjects will undergo all the routine preoperative testing, the same as would be required if they were not participating in this study. this testing includes a blood sample and an electrocardiogram (ecg). follow up visits will be done at 2 weeks after surgery, 6 weeks after surgery, and 1 year after surgery. except for the 1 year visit, these office visits are routine and would be requested even if you were not participating in this study. at each of these visits, subjects will be asked about their level of pain and the amount and type of pain medication their are taking. data gathered for this study will be on outcomes only.

Eligibility criteria:
inclusion criteria: * incisional hernia suitable for repair by laparoscopic techniques exclusion criteria: * not a candidate for laparoscopic surgery * hernia not suitable for laparoscopic repair techniques

Keywords: laparoscopic surgery
focused registry on the titanium trochanter fixation nail advanced (tfnadvanced™)

Conditions: Pertrochanteric Fractures of Femur; Intertrochanteric Fractures of the Femur

Summary: the aim of this project is the prospective data collection of a new device used for trochanteric fractures of the femur. it should be answered how the newly developed implant called trochanteric fixation nailing with anti-rotation feature (tfna) is performing clinically and radiological in terms of intra- and postoperative complications.

in comparison to previous implants, the tfna has been improved substantially. therefore the purpose of this focused registry is to investigate how the newly developed implant called trochanteric fixation nailing with anti-rotation feature (tfna) is performing clinically and radiologically in terms of surgical technique, intra- and postoperative complications and short term outcome. all investigated procedures are part of the standard of care treatment. only the parker mobility score is study-specific. all patients included are followed up from the time point of enrollment until three months after surgery.

Eligibility criteria:
inclusion criteria: * age 18 years and older * pertrochanteric femoral fracture (31-a1 and 31-a2), intertrochanteric fracture (31-a3), fracture of the trochanteric area (31-a1/a2/a3) with diaphyseal extension or combined fracture of the trochanteric area and the femoral shaft (32-a/b/c) treated with the tfna system according to the technique guide * ability to understand the content of the patient information / informed consent form * willingness and ability to participate in the registry according to the registry plan (rp) * signed and dated irb/ec-approved written informed consent or assent from a family member exclusion criteria: * additional acute fracture * any not medically managed severe systemic disease * recent history of substance abuse (i.e., recreational drugs, alcohol) that would preclude reliable assessment * pregnancy or women planning to conceive within the registry period * prisoner * participation in any other medical device or medicinal product registry within the previous month that could influence the results of the present registry * intraoperative decision to use implants other than the devices under investigation

Keywords: trochanteric fracture nail fracture reduction antirotation trochanteric area with diaphyseal extension trochanteric area with femoral shaft
elr monitoring against permanent pacemaker in atrial fibrillation

Conditions: Atrial Fibrillation

Summary: randomised crossover study comparing the sensitivity and specificity of 5 external loop recorders in detecting pacemaker detected atrial fibrillation burden.

the purpose of the study is to compare the diagnostic accuracy of the zio xt , mome, technomed pocket ecg and nuubo to the r-test, our current standard clinical practice, in detection of af burden, in patients with history of paroxysmal atrial fibrillation and have a dual chamber pacemaker or icd in situ, with sensitivity and specificity of af detection calculated from the implanted pacemaker monitored beat to beat holters.

Eligibility criteria:
inclusion criteria: * history of atrial fibrillation * dual chamber pacemaker with advanced holter arrhythmia diagnostics exclusion criteria: * previous av node ablation