Kornimate/medical-research-clean huggingface dataset:
sdh of hpv vaccine completion

Conditions: Human Papilloma Virus

Summary: the purpose of this research study is to find out which factors influence parents' ability to complete the human papillomavirus (hpv) vaccine series for their child. the information learned from this study may help the investigators develop programs to improve hpv vaccine completion rates among adolescents and reduce barriers to receiving the second shot of the vaccine series.


Eligibility criteria:
inclusion criteria: * for adolescents, participants need to be between the ages 11 to 14 years. * received 1 dose of the hpv vaccine series between january 2017 and december 2017. * for parents, there is no age limit required. * parents as defined as the adolescent's biological mother or father, step-parents, or legal guardian. * parents or legal guardians who self-identified as the primary caregiver of the adolescent child and most likely to make medical decisions for the adolescent. exclusion criteria: * parents with cognitive impairment. * adolescents with cognitive impairment. * adolescents emancipated from their parents or legal guardian * pregnant adolescent girls.

Keywords: hpv adolescents hpv vaccine social determinants
genetics of cannabis use disorder and cannabinoid response in humans

Conditions: Schizophrenia; Cannabis Use Disorder

Summary: cannabis is widely used worldwide and is associated with negative outcomes including cannabis use disorder (canud), psychosis, and cognitive impairment amongst others. given the legalization of "recreational" and "medical" cannabis globally, the increasing availability of cannabis, the higher potency of cannabis, the availability of highly potent cannabinoid products, the commercialization of cannabis, and the rising rates of cannabis use, it is critical to understand how genetic factors influence 1) an individual's vulnerability for addiction and psychosis, 2) the response to cannabinoids, 3) the response to novel treatments for canud. canud is strongly genetically influenced; the investigators published the first canud genomewide association study (gwas) with genomewide-significant results; however, the precise nature of the contribution of genetic factors in the development of canud is still not clear. cannabis exposure has also been linked to a number of psychosis outcomes including schizophrenia (scz). scz is highly heritable and population-based and genetics studies both support a bidirectional genetic relationship between scz and canud. however, the precise contribution of genetic factors in the development of psychosis outcomes related to cannabis are not clear.


Eligibility criteria:
inclusion criteria: -ages 21-60 years old exclusion criteria: * major or unstable medical conditions based on history, the structured clinical interview for dsm-5, collateral information, physical and laboratory examinations, ecg, and vital signs. * cannabis naïve individuals * positive pregnancy test
mexiletine for muscle cramps in charcot marie tooth disease

Conditions: Charcot Marie Tooth Disease

Summary: charcot marie tooth disease is a family of inherited peripheral neuropathies, with over 70 causative genes identified to date.1-4 muscle cramps are frequent in cmt, affecting up to 85% of patients with some subtypes of cmt. these cramps impact quality of life and have been identified as an important therapeutic target for clinical trials in cmt.1-4 there is no fda approved treatment for muscle cramps.5 mexiletine is a sodium channel blocker approved for treatment of arrhythmias. as a sodium channel blocker, mexiletine offers the promise of effective therapy for muscle cramps.

this study will provide data on the short term efficacy of oral mexiletine in helping to prevent muscle cramps in adults with cmt. the study will also assess the short-term safety and tolerability of low dose mexiletine in adults with cmt.

Eligibility criteria:
inclusion criteria: * the subject has known cmt, previously diagnosed by a neurologist with subspeciality expertise in neuromuscular disorders/peripheral neuropathy. the diagnosis of cmt relies on a combination of clinical history (including family history), neurological examination electrophysiological features, and prior genetic testing results. * the subject is at least 18 years old, and has signed the informed consent form. * the subject is ambulatory (cane, walker, orthoses allowed). * the subject has experienced muscle cramps and has known provokable hamstring or calf muscle cramps on mvc. * the subject has a reliable method of birth control (if a female subject of child bearing potential). reliable birth control is defined as hormonal contraception intrauterine contraception/device any two barrier methods (combination of male or female condom with diaphragm sponge or cervical cap) together with spermicidal foam/gel/film/cream/suppository true abstinence exclusion criteria: * the subject has a known neuropathy from another source (e.g., diabetes, drug induced, alcohol, etc.). * the subject has an untreated medical disorder known to predispose to muscle cramps * the subject is pregnant or nursing, has a known mexiletine allergy or has taken mexiletine in the past 12 weeks. * the subject is participating in another therapeutic trial. * the subject has second or 3rd degree heart block, atrial flutter/fibrillation, ventricular arrhythmias, or is receiving treatment of a cardiac arrhythmia. * the subject is currently taking another agent for muscle cramps or a muscle relaxant (e.g., benzodiazepine, baclofen, tizanidine, soma, meprobromate). * the subject is on another sodium channel blocker or medication that precludes administration of mexiletine. * the subject has known diabetes mellitus, liver or kidney disease requiring ongoing treatment, untreated thyroid dysfunction, symptomatic cardiomyopathy, or symptomatic coronary artery disease. * the subject, in the opinion of the investigator, is unsuitable for enrollment for any other reason
analysis of the understanding of the french version of the vulvar pain assessment questionnaire

Conditions: Vulvodynia

Summary: prior to the current study, a translation into french of the screening version of the vpaq (vpaqscreen) and its supplemental scales (vpaqdesc, vpaqcope, vpaqpartner) was performed according to the recommended process. the present study aims to evaluate the understanding of this translation on a panel of 30 women suffering from provoked or mixed vestibulodynia.

the vulvar pain assessment questionnaire (vpaq) is a self-assessment questionnaire for chronic vulvar pain. the english-language version has been validated on patients suffering from chronic pain of various causes, mainly vulvodynia. it explores the biopsychosocial dimensions of chronic vulvar pain: description, intensity, temporality, associated symptoms, emotional and cognitive functioning, coping strategies and interpersonal relations with the partner. the vpaq inventory is divided into a main questionnaire (vpaqfull or a shorter version, vpaqscreen) and 3 supplementary questionnaires exploring pain descriptors (vpaqdesc), coping strategies (vpaqcope) and partner factors (vpaq partner). the vpaq inventory can be used both for research purposes and clinical practice. indeed, it helps the patients to better express their symptoms and the providers to cover with one tool all the dimensions of chronic vulvar pain. a french translation would make the vpaq inventory available for french speaking health care professionals and patients. the aim of our study is to validate a french translation of the vpaqscreen and its three supplementary questionnaires. prior to this study, a french translation of these questionnaires was performed according to the recommended process. whereas the english vpaq inventory has been validated on patients with chronic vulvar pain, whatever the cause, the investigators have chosen to carry out this validation on a homogeneous population of women suffering from provoked or mixed vestibulodynia (i.e, pain located on the vulvar vestibule, triggered by local contacts and associated or not with spontaneous pain). indeed, provoked vestibulodynia is the most frequent and the best-defined clinical subset of vulvodynia (i.e, chronic vulvar pain with no identifiable cause). the investigators excluded patients suffering from vulvodynia involving other sites than the vestibule as well as chronic vulvar pain related to specific causes (neurological, myofascial, etc..) the understanding of this french translation of the vpaq will be tested on a panel of 30 patients.

Eligibility criteria:
inclusion criteria: * patients over 18 years of age * with a diagnosis of provoked or mixed vestibulodynia confirmed by an expert gynecologist or vulvar dermatologist * have signed a consent form * french mother tongue and able to read * affiliated to a social security scheme exclusion criteria: * patient with vulvar pain associated with other pathologies * deprived of liberty or under guardianship.
hyper polarized xenon-129 mri vs xenon-133 scintigraphy

Conditions: Chronic Obstructive Pulmonary Disease

Summary: hyper polarized xenon-129 mri will be directly compared to a radioactive xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation. this study is conducted as a pilot study with intention to conduct a larger clinical trial.

hyperpolarized xenon-129 mri has been developed by a number of techniques for imaging the lung that provide information about various aspects of lung function and structure. the main objective of this pilot study is to test and optimize the imaging parameters for a future industry sponsored clinical trial. the goal of the future trial is to determine the concordance between hyperpolarized xenon-129 ventilation mr imaging and nuclear medicine ventilation imaging (gold standard). in this study we will test the imaging parameters and techniques. we will directly compare human ventilation lung images in subjects with copd, using nuclear medicine ventilation imaging with xenon-133 gas scintigraphy versus hyperpolarized xenon-129 gas mri. our hypothesis is that current xe-133 scintigraphy, which uses a radioactive gas (xe-133) and produces a projection image of the lungs with relatively poor resolution, will not be able to detect small lung ventilation obstructions, which can be detected using hyperpolarized xe-129 gas mri.

Eligibility criteria:
inclusion criteria: * subjects must have a diagnosis of copd * at their clinical baseline on the day of imaging * must be clinically stable in order to participate in the study. * copd subjects will be categorized according to the gold * current/former smokersubjects * must have a smoking history ≥ 10 pack years exclusion criteria: * dx of asthma * continuous oxygen use at home * blood oxygen saturation of 92% less than as measured by pulse oximetry on the day of imaging * fev1 percent predicted less than 25% * pregnancy or lactation * claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign bodies in eye, pacemaker or other contraindication to mr scanning * subjects with any implanted device that cannot be verified as mri compliant will be excluded * chest circumference greater than that of the xenon mr and/or helium coil. the circumference of the coil is approximately 42 inches * history of congenital cardiac disease, chronic renal failure, or cirrhosis * inability to understand simple instructions or to hold still for approximately 10 seconds * history of respiratory infection within 2 weeks prior to the mr scan * history of mi, stroke and/or poorly controlled hypertension.
eighteen-month orthodontic bracket survival rate with the conventional bonding technique versus rmgic and v-prep

Conditions: Dental Malocclusion

Summary: the aim of this study was to evaluate over eighteen months the clinical bonding failure and survival rates of the conventional bonding technique using the transbond xt (3m unitek, monrovia, california, usa) and the rmgic fuji ortho lc (gc corporation, tokyo, japan) prepared with the v-prep. therefore, one operator using the straight-wire technique bonded two hundred metallic brackets to upper and lower premolars of twenty-five patients requiring an orthodontic treatment. the randomized trial was a single-blind design in a split-mouth comparison. each patient was randomly allocated one of the two bonding systems for each premolar on each side of the mouth. the bonding and rebonding techniques were standardized throughout the trial and bond failure was recorded each month for a period of eighteen months.


Eligibility criteria:
inclusion criteria: * require full orthodontic treatment of both arches * mild or average overbite and crowding * no restorations on the buccal surface of the premolars exclusion criteria: * patients with required extractions in the treatment plan or with poor oral hygiene

Keywords: resin-modified glass ionomer surface preparation orthodontic bracket
prospective multicentric study comparing the acute hemodynamic effect of three modes of stimulation in cardiac resynchronization therapy recipients

Conditions: Heart Failure; Cardiac Resynchronization Therapy

Summary: cardiac resynchronization therapy (crt) is an established treatment for patients with systolic heart failure and bundle branch block, improving functional capacity, quality of life and reducing morbi-mortality. adjusting atrio-ventricular (av) delay, vector optimization and choice of different modes of stimulation can influence the acute hemodynamical consequences of crt but also its medium-term and long-term clinical and echocardiographic effects. the aim of the present prospective study is to investigate whether the different stimulation modes lead to different acute hemodynamic response, by evaluating the highest systolic pressure using the finapress ® method.

this study is a non-randomized, prospective, interventional, multicentric study. patients implanted with an abbott ® crt pacemaker or defibrillator since less than 3 months are eligible for the study. recruited patients will be submitted to a non-invasive evaluation of different pacing modes. this will be performed using the finapress nova device, which records blood pressure with a digital cuff. the peak of blood pressure will correspond to the optimal device settings three modes of stimulation of abbott crt devices will be compared: * classical bi-ventricular pacing mode at nominal value and with av delay optimization * syncav mode at nominal value or with left ventricular preexcitation optimization * multipoint pacing (mpp) mode, alone or in combination with syncav mode this is an acute evaluation study without scheduled follow-up.

Eligibility criteria:
inclusion criteria: * patient older than 18 * implantation of a crt (crt-p or crt-d) less than 3 months before inclusion * mpp and syncav-enabled abbott quadripolar crt pacing system * patient who had signed an informed consent and is willing to comply with study requirements * de novo implantation * patient covered by national healthcare insurance exclusion criteria: * permanent/persistant atrial fibrillation/ supra-ventricular tachycardia * pacing indication for 2nd or 3rd degree av block * upgrading from non-crt system * pregnant or breastfeeding women * adult under legal protection

Keywords: cardiac resynchronization therapy atrioventricular delay optimization multipoint pacing negative atrioventricular hysteresis non invasive hemodynamic optimization heart failure
turn-it fog: improving turning and freezing of gait in people with pd

Conditions: Parkinson Disease; Freezing of Gait Symptoms in Parkinson&#39;s Disease

Summary: the goals of this clinical trial are to 1) learn how two different rehabilitation interventions for pd can reduce freezing of gait (fog) in people with parkinson's disease, as assessed by patients, clinicians, and wearable sensors, and 2) to explore whether two different rehabilitation intervention can reduce fog and improve daily life mobility in people with fog sufficiently to justify a clinical trial. participants will: * be randomly assigned to one of two intervention groups (turning-focused agility exercise or strength-based exercise) * have one-on-one training sessions three times per week for 6 weeks * perform in-lab assessments before beginning and after completing the study intervention * use wearable mobility sensors during daily life to measure their walking and balance


Eligibility criteria:
inclusion criteria: * a) diagnosis of idiopathic pd from movement disorders neurologist with the united kingdom brain bank criteria of bradykinesia with one or more of the following - rest tremor, rigidity, and balance problems not from visual, vestibular, cerebellar or proprioceptive conditions; b) reporting fog in the new freezing of gait questionnaire (n-fogq); b) hoehn \& yahr stages ii-iv; c) ages 50-80 years old, d) cognitive ability sufficient to participate in testing procedures and exercise classes, and e) be willing and able to participate in exercise intervention 3x/week for 6 weeks. exclusion criteria: * a) major musculoskeletal or neurological disorders, structural brain disease, epilepsy, acute illness or health history, other than pd, significantly affecting gait and turning (i.e., musculo-skeletal disorder, vestibular problem, head injury, stroke, cardiac disease ); b) medical condition or medications that precludes moderate-intensity exercise; c) montreal cognitive assessment (moca) ≤21 or inability to follow directions; d) excessive use of alcohol or recreational drugs; e) recent change in medication; f) inability to stand and walk for 2 minutes without an assistive device.
hope theory as ability determinant to permanently change the adapted physical activity (apa) in type 2 diabetic patients

Conditions: Type 2 Diabetes

Summary: the control of diabetes is related both to food, treatment but also to physical activity. despite these recommendations and these positive findings, patients are always sedentary because of brakes in the practice of a regular physical activity. it is therefore interesting to consider the representations of patients and particularly on the way of establishment in order to reach a goal. the hope theory highlights the hope as the sum of the will and means that an individual has to achieve its goals. will be discussed in this study to identify a relationship between the level of hope for patients and their ability to permanently change their behavior in regular physical activity as part of the goals set during the week of therapeutic education patient.


Eligibility criteria:
inclusion criteria: * major topic * type 2 diabetic topic * inactive topic * subject of chu angers hospitalized for a week diab'equilibre, diabetology service * subject participating in the service of the apa program * subject who understands and reads french * subject has given its consent to participate signed the protocol exclusion criteria: * removing the participation of consent; * severe heart failure * severe respiratory failure * bone metastases
intravenous tranexamic acid versus vaginal dinoprostone in abdominal myomectomy

Conditions: Myomectomy

Summary: the aim of the present study is to evaluate safety and efficacy of intravenous tranexamic acid versus vaginal dinoprostone in reducing intraoperative blood loss during abdominal myomectomy


Eligibility criteria:
inclusion criteria: * symptomatic fibroids candidate for abdominal myomectomy exclusion criteria: * patients candidate for laparoscopic or hysteroscopic myomectomy or had contraindications or allergy to dinoprostone or tranexamic acid
study to evaluate the effects of psyllium on blood glucose

Conditions: Healthy Men

Summary: this is an open label, single use, randomized, 4-period cross-over study. in each period, subjects will receive one of 4 test combinations. blood will be drawn prior to study product consumption and following study product consumption for glucose measures.


Eligibility criteria:
inclusion criteria: * male * 18 to 50 years of age * general good health * body mass index (bmi) in the range of 18.5-29.9 kg/m2 * fasting plasma blood glucose \<126mg/dl * not actively treated for high blood glucose * willing and able to have blood drawn at multiple times during each 4 visits exclusion criteria: * history of allergy or hypersensitivity to inhaled or ingested psyllium or meal ingredients * phenylketonuria (pku) * an eating disorder * following special medical or weight-loss dietary restrictions * taking dietary supplements or prescription medication for the purpose of weight loss/management
effects of transcranial direct current stimulation (tdcs) in chronic corneal pain

Conditions: Corneal Pain; Chronic Pain; Neuropathic Pain

Summary: in this study the investigators aim to examine the effects of transcranial direct current stimulation (tdcs) on pain levels as well as the changes in cognitive (thought) processing in individuals with chronic pain of the cornea -- and also compared with healthy controls.


Eligibility criteria:
inclusion criteria (for all subjects): 1. provide informed consent to participate in the study; 2. 18 to 65 years old; additional inclusion criteria for subjects with chronic corneal pain: 1. corneal pain for six months or more; 2. referral from a corneal specialist (dr. perry rosenthal) with refractoriness to conventional ophthalmologic treatments for corneal pain such as local topical medications and soft bandage contact lenses; 3. report a visual analogue scale (vas) for pain of 4 or greater in the previous 3 weeks; exclusion criteria (for all subjects): 1. history of alcohol or substance abuse within the last 6 months as self-reported; 2. diagnosis of any neurological diseases (such as epilepsy); 3. episodes of seizures within the last 6 months; 4. unexplained loss of consciousness 5. use of carbamazepine or neuropsychotropic drugs 6. contraindications to tdcs * metal in the head * implanted brain medical devices 7. pregnant at time of enrollment

Keywords: transcranial stimulation direct current stimulation
a phase ii study of cetuximab plus irinotecan in patients with egfr-detectable metastatic colorectal carcinoma

Conditions: Colorectal Carcinoma

Summary: to evaluate the response rate of cetuximab plus irinotecan combination therapy in subjects with egfr-detectable metastatic colorectal carcinoma who have documented progressive disease to irinotecan-based chemotherapy and who have failed (progressive disease or intolerance) previous oxaliplatin-based and fluoropyrimidine-based chemotherapies.


Eligibility criteria:
inclusion criteria: * the subject must have surgically unresectable metastatic colorectal carcinoma. * the subjects who have received and failed ilinotecan, oxaliplatin and fluoropyrimidine-based chemotherapy * ecog ps 0-2 exclusion criteria: * subjects with symptomatic cerebral metastasis

Keywords: egfr-detectable metastatic colorectal carcinoma with documented progressive disease to irinotecan-based chemotherapy and failure