Kornimate/medical-research-clean huggingface dataset:
polymorphisms in inflammatory cytokines genes in subjects with obstructive sleep apnea

Conditions: Sleep Apnea

Summary: obstructive sleep apnea is a common sleep disorder. it is known to be related with increased body mass, abdominal obesity, insulin resistance and hypertension. it is currently believed to be a feature of the metabolic syndrome. other features of the metabolic syndrome-such as insulin resistace were found related to inflammation and inflammatory cytokines. several polymorphisms in the genes that encode interleukin 6,inteleukin 10 and tnf-alpha have significant influence on the amounts of cytokine production. we thus hypothesize that polymorphisms related to increased pruduction are more common in subjects with osa than in matched controls

patients attending a sleep apnea clinic for evluation will be recruited. patients found positive for osa will be compared to the patients with a negative study for osa for the prevalence of polymorphisms in genes of inflammatory cytokines and cytokine levels

Eligibility criteria:
inclusion criteria: * patients attending the sleep apnea clinic for evaluation exclusion criteria: * patients known to have inflammatory conditions

Keywords: osa inflammatory cytokines, metabolic syndrome
effects of vaginal seeding on infants' body mass index and allergy risk for caesarean-delivered children

Conditions: Overweight and Obesity; Allergy

Summary: this is a single-blind randomized controlled trial, aiming to evaluate the effects of vaginal seeding on body mass index as well as allergy risk for cesarean-delivered infants. it will be conducted in liuyang city of china, and the targeted sample size is 106. all the eligible pregnant women will be randomly assigned to either the intervention or control group, and their babies of the participants will be followed up to 24 months of age.

many studies have suggested that caesarean-delivered children are at higher risks of developing metabolic and allergic diseases like obesity and asthma, possibly because newborns born by caesarean section were lack of exposure to maternal vaginal flora. it is needed to explore a simple, convenient, and safe intervention strategy to reduce caesarean-related risks. in a recent non-randomized study, the authors found that exposure of caesarean-delivered newborns to maternal vaginal fluid at birth (i.e., vaginal seeding) could partially restore the microbiota of them at 30 days after births, but the long-term health consequences of restoring the microbiota of caesarean-delivered infants remain unclear. in this randomized study, the investigators aim to examine whether the changes in newborns' microbiota will persist to 24 month of age, and whether vaginal seeding will have any effects on body mass index and allergy risk from birth to 24 months of age. the investigators will enroll a total of 106 pregnant women, and the participants' infants will be followed up at 0 (before hospital discharge), 6, 12, 18 and 24 months. at each follow-up visit, a questionnaire survey including information on feeding, medication, and allergic status will be conducted, infants' height and weight will be measured, and feces will be collected. at 18-month-old visit, infants' venous blood will be also collected for the assay of multiallergen. the primary outcomes were body mass index and allergy risk index. the secondary outcomes included the microbiota profile, allergic symptoms and diseases, overweight/obesity, and adverse effects.

Eligibility criteria:
inclusion criteria: * local resident in liuyang city * singleton, term pregnancy (≥37 weeks of gestation) * cesarean section before labor starts without maternal complications, or cesarean section after the start of labor but the cervix is less than 3 cm * vaginal ph\< 4.5 at enrollment exclusion criteria: * positive testing for hiv, hbv, syphilis or gbs infection at gestation * vaginal infections such as genital herpetic lesions or chlamydia * bacterial vaginosis * trichomonas or fungous in leucorrhea * pregnant women or her spouse with severe allergic diseases, such as asthma and severe drug allergy * vaginal ph ≥4.5 at 1-2 hours before the cesarean section * other conditions not suitable for intervention as judged by obstetricians

Keywords: body mass index allergic risk vaginal seeding randomized controlled study caesarean delivery overweight and obesity
the predictive effect of the inflammatory response on the evacuation of mechanical ventilation and the mechanism

Conditions: Systemic Inflammatory Response Syndrome; Ventilator Weaning

Summary: infection and trauma take a important role in the acute respiratory failure.there are different causes and degrees of inflammatory reaction in the critically ill patient. the inflammatory reaction should also affect patients on mechanical ventilation dependence with body physiological response and disease prognosis in patients. therefore, the investigators hypothesize that inflammation may have an important role in the prediction of weaning from mechanical ventilation.

in the process of mechanical ventilation, the patients were divided into two groups according to the failure of spontaneous breathing test and spontaneous breathing test.in the index of predicting mechanical ventilation, the investigators will take the index of inflammatory response, the function index of diaphragm and the amount of exhaled co2 into account to reduce the failure rate of mechanical ventilation.

Eligibility criteria:
inclusion criteria: * oral, nasal tracheal intubation and mechanical ventilation in patients with respiratory failure * mechanical ventilation time over than 48 hours * glasgow score greater more than or equal to 13 points exclusion criteria: * aged less than 14 years or more than 80 years old * patients with neuromuscular disease * pure heart failure pulmonary edema patients * patients with tracheotomy

Keywords: inflammatory factor mechanical ventilation
relationship between methods of bladder tumor extraction and local recurrence rate

Conditions: Bladder Cancer

Summary: according to clinical guidelines, endoscopic surgery (mono- or bipolar turbt, laser resection, en bloc resection) is a standard treatment option for patients with primary non-muscle invasive bladder cancer (nmibc) (excluding carcinoma in-situ). however, more than half of patients will experience local recurrence after surgery. it is believed that one of the main causes for this local recurrence is the reimplantation of tumor cells during endoscopic surgery. it is crucial to limit contact between the resected tumor and the bladder wall during the operation and to extract the specimen as quickly as possible. in the case of a small tumor, the surgeon can immediately remove it using an endoscopic instrument. there are a number of methods available for removing large tumors, but it is not yet clear which one is most optimal. therefore, comparing the oncological results from evacuating bladder tumors using various methods is very timely. based on the previously mentioned studies, the investigators assume that the rate of bladder cancer relapse out site of the resection area would be lower in the morcellation group compared with piecemeal resection of the tumor. in order to prove this, the investigators plan to conduct a randomized study comparing the relapse rate in these two groups.


Eligibility criteria:
inclusion criteria: 1. patients scheduled for endoscopic bladder tumor removal 2. non-muscle invasive bladder cancer on contrast-enhanced mri or ct (stage ct1n0m0 and lower) 3. diameter of tumor \>3cm exclusion criteria: 1. patient refused to participate in the trial 2. multiple (more than 2) bladder tumors 3. previous cold-cup biopsy or any other surgery for bladder tumor 4. muscle-invasive bladder cancer on postoperative histological evaluation 5. other malignant/benign tumors of the bladder (non-urothelial cancer)
fluid volume-hypotension association in cesarean under neuraxial anesthesia

Conditions: Cesarean Section

Summary: hypotension resulted from neuraxial block is a common problem, of which is a special issue in patients undergoing cesarean section. a large number of studies and clinical guidelines suggest that fluid loading, pre- or co-anesthesia, is a promising manner in preventing hypotension. however, it is still a controversy because the fact of a relatively increased blood volume in parturients. in addition, although it is effective of fluid management, it's precise relationship between fluid (crystalloid or colloid) volume and the proportion of hypotension in cesarean patients under neuraxial anesthesia is still unknown. the investigators designed this trial to clarify the accurate relationship between fluid volume in an escalated manner and the occurrence of hypotension analyzed with a non-linear regression, and wanted to present the 50% effective volume (ev50) of fluid including crystalloid and colloid in preventing hypotension in patients undergoing cesarean section.


Eligibility criteria:
inclusion criteria: * 21-40 yr * first time of delivery * asa status i-ii * no premature * no genetic and infectious diseases * chinese exclusion criteria: * \< 21 yr * \> 40 yr * subjects with cardiac and pulmonary disorders * dislocation of placenta * pregnant hypertension * allergy to local anesthetics * unwilling to cooperation * need intraoperative administration of vascular active agents * with significant delivery side effects * with contradictions of neuraxial anesthesia

Keywords: epidural anesthesia spinal anesthesia combined spinal-epidural anesthesia fluid therapy crystalloid colloid
a study of mrg003 in combination with pucotenlimab versus chemotherapy in the treatment of patients with recurrent or metastatic nasopharyngeal carcinoma

Conditions: Recurrent or Metastatic Nasopharyngeal Carcinoma

Summary: this is a randomized, open-label, multi-center, phase iii study to evaluate the efficacy and safety, and immunogenicity of mrg003 in combination with pucotenlimab in patients with recurrent or metastatic nasopharyngeal carcinoma.


Eligibility criteria:
inclusion criteria: * willing to sign the informed consent form and follow the requirements specified in the protocol. * life expectancy ≥ 12 weeks. * patients with histologically and cytologically confirmed recurrent or metastatic nasopharyngeal carcinoma (npc) who have failed at least one line of prior systemic therapy. * patients must have at least one measurable lesion according to the response evaluation criteria in solid tumors (recist v1.1). * the score of ecog for performance status is 0 or 1. * no severe cardiac dysfunction, left ventricular ejection fraction (lvef) ≥50%. * organ functions and coagulation function must meet the basic requirements. * patients with childbearing potential must use effective contraception during the treatment and for 6 months after the last dose of treatment. exclusion criteria: * history of hypersensitivity to any component of the investigational product. * received systemic chemotherapy, targeted therapy, biological therapy or immunotherapy for anti-tumor purpose, or major surgery within 3 weeks prior to the first dose of study treatment. * received anti-infection therapy within 2 weeks prior to the randomization * prior treatment with mmae/mmaf adc drugs * central nervous system metastasis. * poorly controlled systemic diseases * patients with poorly controlled heart diseases * poorly controlled pleural and peritoneal effusion or pericardial effusion * ≥grade 2 toxic reaction or abnormal value of laboratory test caused by previous anti-tumor treatment * patients with prior ≥grade 3 immuno-related adverse events (iraes) * any clinically significant arteriovenous bleeding, pulmonary embolism, or deep venous thrombosis occurred within 3 months * received allogeneic tissue/solid organ transplantation. * inoculate live vaccine within 30 days before the first dose. * patients with a positive serum pregnancy test or who are breast-feeding or who do not agree to take adequate contraceptive measures during the treatment and for 180 days after the last dose of study treatment. * history of other primary malignant tumor diseases. * other situations that are not suitable to participate a clinical trial per investigator's judgement

Keywords: mrg003 pucotenlimab nasopharyngeal carcinoma
minnesota inclusive ltss for lgbtq seniors

Conditions: Alzheimer Disease; Dementia

Summary: this study is designed to help improve the care of sexual and gender minority (sgm) with alzheimer's disease and alzheimer's disease related dementia (ad/adrd) in long-term services and supports (ltss) by training the state's ltss workforce in sgm culturally responsive care. the randomized controlled trial will rigorously test the effects of an in person versus an online training program on improving sgm culturally responsive care with a waitlist control.

the study involves conducting a 3-arm, stratified (management/staff), group (agency) randomized controlled trial (rct) of the in-person vs. online intervention vs. waitlist control on organizational factors (i.e., environment and policy) and on staff knowledge, attitudes, and skills.

Eligibility criteria:
inclusion criteria: * licensure in minnesota to provide nursing and/or as a housing with services establishment * willingness to undertake a policy and environment review at baseline and 6 months later * having at least 5 managers/ supervisors and 5 staff. exclusion criteria: * participants who cannot speak and read english

Keywords: long-term support and service facilities alzheimer disease dementia ltss seniors
physiological study to assess mechanism of action of mobiderm® in lower-limb lymphedema patients

Conditions: Lymphedema of Leg; Lymphedema Congenital; Lymphedema Primary; Lymphedema, Secondary

Summary: mobiderm® demonstrated his interest through clinical studies on the treatment of lower or upper limb lymphedema (mestre et al 2017; quéré et al. 2014). this ce (conformity european)-marking device is well established both in ambulatory and hospitalisation. nevertheless, the mechanism of action of this device had never been confirmed and no experimental clinical studies had been performed. the hypothesis is that the mobiderm system creates a pressure differential between the contact zone underneath the foam cubes composing the system and their surrounding area, leading to a shear effect on the subcutaneous tissues treated. the aim of this study is thus to assess the mechanism of action of mobiderm on the lymphatic system by evaluating quantitative and qualitative effects of this medical device on lymphatic system, oedema volume and cutaneous parameters in 10 lymphoedema patients during their hospitalisation for reduction phase.


Eligibility criteria:
inclusion criteria: * primary or secondary lower limb lymphedema of stage 2 or 3 according to the criteria defined by international society of lymphology * affected leg that fits with one of the standard sizes of the auto-adjustable mobiderm® autofit stocking provided * signed informed consent prior to any study-mandated procedure. exclusion criteria: * pregnant or breastfeeding patient * childbearing age patient without contraception * intolerance to mobiderm or known allergy to the components used * evolutive lower limb infection * acute lower limb inflammation * dermatological ailment oozing from the treated limb * severe medical condition that may interfere with the proper conduct of the study * advanced diabetic microangiopathy * limb arteritis stage iii or iv * decompensated heart failure * involvement in another clinical study * patient mentally incapable of understanding the nature, objectives and possible consequences of the study and / or refusing to submit to the constraints of this trial

Keywords: lymphedema, auto-adjustable mobiderm® autofit stocking lymphoscintigraphy mechanism of action
copd prognosis in covid patients

Conditions: Respiratory Failure

Summary: in this prospective observational study, patients were selected from attendees of the intensive care unit. different measures and outcomes had been studied and compared between patients with and without copd, including hospitalization, medical costs, length of intensive care stay, respiratory failure, and death rate.


Eligibility criteria:
inclusion criteria: * age: more than 20 years old. * both males and females will be included. * copd patients. * recent confirmed the diagnosis with sars-cov-2. exclusion criteria: * pregnancy. * malignancy. * immunodeficiency disease

Keywords: copd, prognosis, covid
study on the population pharmacokinetics of levetiracetam in epileptic patients with diabetic kidney disease

Conditions: Epilepsy; Diabetic Nephropathy

Summary: the individualized drug delivery system of levetiracetam based on population pharmacokinetics and quantitative pharmacology model in patients with epilepsy complicated by diabetic kidney disease was established. to clarify the clinical feasibility of model-based individualized drug administration scheme.

a quantitative pharmacological model for the development of levetiracetam in epileptic patients with diabetic nephropathy is proposed. first, a model based active levetiracetam based individualized initial dose regimen was established by using clinical simulation techniques. a simulation model was established for patients with diabetes mellitus and kidney disease, including information on patients' gender, age and other factors, diabetes mellitus, renal disease history, creatinine clearance rate, glomerular filtration rate, urinary protein level and blood lipid level. secondly, the simulated clinical trial combining simulation model and population pharmacokinetic model is used to compare the compliance rate of levetiracetam blood concentration in patients with different dose treatment schemes, so as to obtain the optimal individualized administration scheme. finally, bayesian feedback technology is used to improve the passive dose adjustment scheme, and model-based bayesian feedback technology is used to establish a dose adjustment scheme based on area under curve (auc), so as to clarify the optimal blood sampling scheme and monitoring method.

Eligibility criteria:
inclusion criteria: - patients with seizures and diabetic nephropathy who were treated with levetiracetam. exclusion criteria: * patients who rejected

Keywords: levetiracetam population pharmacokinetics
effects of sleep deprivation on diaphragm command during an inspiratory endurance trial in healthy volunteers.

Conditions: Sleep Deprivation; Healthy Volunteers; Diaphragm

Summary: the purpose of this study is to assess the impact of sleep deprivation on subjective inspiratory endurance in healthy subjects.

sleep in intensive care unit is altered and few studies have suggested that sleep deprivation (sd) could impact respiratory muscle endurance. a lack of inspiratory endurance could lengthen weaning from invasive ventilation. the purpose of this study is to confirm whether sd alters inspiratory endurance and to identify brain mechanisms involved in sd-induced decreased endurance. a group of 20 male healthy subjects will perform an inspiratory load trial after a normal sleep night and after a sleepless night. electrophysiological parameters (eeg, motor evoked potentials) of the inspiratory motor command and sensory perceptions will be assessed before, during and after each trial.

Eligibility criteria:
inclusion criteria: * male adult volunteers * aged 25 to 45 years * regularly sleeping more than 6 hours per night * not excessive coffee consumers (\< 3 expressos / day) * non smokers * absence of respiratory, cardiac, muscular or neurological disease or diabetes * with a neutral horne \& ostberg score exclusion criteria: * previous history of respiratory disease or otorhinolaryngological (asthma, respiratory allergies, swallowing disorders, oropharyngeal malformations) * history of epilepsy or syncope during sleep deprivation * taking medications that interfere with sleep (antidepressants, benzodiazepines...)
taxane induced peripheral neuropathy in chinese patients with breast cancer

Conditions: Breast Cancer

Summary: the purpose of this study is to collect clinical data, blood samples, and self reported symptoms of peripheral neuropathy from chinese patients with breast cancer after treatment with taxanes. this data will be used to develop predictive markers for neuropathy.


Eligibility criteria:
inclusion criteria: * diagnosis of breast cancer * females aged 16 and older * planning to receive or previous treated with taxanes exclusion criteria: * poorly controlled or insulin-dependent diabetes or other condition likely to predispose to neurotoxicity
cholecalciferol supplementation in restless leg syndrome in patients with chronic kidney disease

Conditions: Restless Leg Disorder; Renal Disease Bone; Renal Disease, End Stage; Hyperparathyroidism, Secondary; Adynamic Bone Disease; Vitamin D Deficiency

Summary: restless leg syndrome (rls) is sleep disorder characterized by an unpleasant feeling in the lower limbs, which can be accompanied by paresthesias, and need for urgent movement of the legs. its diagnosis is clinical, based on an international committee of the study of rls (international restless legs syndrome study) questionnaire. its prevalence is about 5-15% in the general population, being twice as frequent in women and with a tendency to increase incidence with aging. in the chronic kidney disease (ckd) population, mainly in patients on dialysis, the prevalence increases by up to 70%. vitamin d deficiency is associated with rls and active vitamin d supplementation seems to improve rls and severity. it is seems, studies on the role of vitamin d supplementation in ckd population are missing. the clinical-scientific hypothesis of this study is that replacement of vitamin d (cholecalciferol) will improve the symptoms of rls. as parathyroidectomy can relieve rls, the aim of researchers is to randomize patients with ckd on dialysis to receive cholecalciferol or placebo in 2 distinct groups: secondary hyperparathyroidism and adynamic bone disease.


Eligibility criteria:
inclusion criteria - adult patients with chronic kidney disease on dialysis, with vitamin d deficiency. exclusion criteria * current treatment for restless leg syndrome * history of parathyroidectomy in the last 6 months
treatment of leg telangiectasias with nd:yag 1064nm

Conditions: Telangiectasias

Summary: studying the results of treatment of dilated vessels of the lower limbs with laser, and compare them to those obtained with sclerotherapy.


Eligibility criteria:
inclusion criteria: * patients with leg telangiectasias exclusion criteria: * arterial disease * varices * diabetes

Keywords: telangiectasias leg sclerotherapy laser glycose
cross-linked cmc and silk proteins in corneal re-epithelization

Conditions: Corneal Epithelial Wound Healing

Summary: data analyses and revision of the corneal re-epithelization in patients who underwent either prk (photorefractive keratectomy), cxl (corneal cross-linking), ptk (phototherapeutic keratectomy), or experienced a corneal abrasion. a novel ophthalmic solution containing cross-linked cmc (cx-cmc) and silk proteins (sp) has been made available on the market. both molecules have been widely studied for their wound healing properties in the ophtalmic field. this new ophthalmic solution is the first on the market formulated with a cx-cmc and sp.


Eligibility criteria:
inclusion criteria: * patients who had undergone surgical procedures involving de-epithelialization, which included cxl, prk, and ptk, as well as those with a first diagnosis of corneal abrasion exclusion criteria: * patients with known allergies or hypersensitivity to any components of the tested formulations or standard therapies, or those requiring different treatments compared to the rest of the study population