Kornimate/medical-research-clean huggingface dataset:
chronic kidney disease in pregnant females

Conditions: CKD

Summary: screening of chronic kidney disease among pregnant women for early detection

normal pregnancy associated with plasma volume expansion and hormonal changes lead to an increase in gfr of 40% to 65% in first and second trimester , with decrease in gfr of approximately 15% to 20% in the third trimester . chronic kidney disease (ckd) is defined as abnormalities of kidney structure or function, present for a minimum of 3 months, with significant health implications .ckd classification is based on cause, gfr category (g1-g5), and albuminuria category (a1-a3), abbreviated as cga . ckd during pregnancy is a major health concern ,affecting up to 3% of women of reproductive age in high-income countries, but estimated prevalence may be as much as 50% higher in low and middle-income countries (lmics). pregnant women with ckd at high risk of adverse maternal and fetal outcome , including hypertension development or worsening ,preeclampsia, eclampsia , anemia , platelets abnormalities , worsening kidney function ,need for cesarean section ,pregnancy loss ,stillbirth ,preterm labor ,intrauterine growth restriction . ckd if detected and treated early in its course, esrd is often preventable, especially for high risk individuals. ckd is often unrecognizable and asymptomatic until it is in its later stages, when the chances of preventing kidney failure are limited. therefore, in order to administer targeted therapeutic interventions . early identification and stratification of those at highest risk of ckd are urgently needed. screening programs using state of the art point-of-care testing equipment with blood and urine samples can test for ckd both quickly and accurately

Eligibility criteria:
inclusion criteria: * -all pregnant women at antenatal care who came to outpatient clinic at the women's health hospital and nephrology outpatient clinic at assiut university hospitals * at age of 18 yrs old or above . -who accept to participate with this study exclusion criteria: * pregnant women who are known ckd. * pregnant women refuse to participate with this study . * pregnant women with acute kidney injury .
idiopathic anemia of aging (iaa)

Conditions: Anemia; Aging

Summary: the purpose of this trial is to examine whether epoetin alfa, a hormone stimulating production of red blood cells, can reverse idiopathic anemia.

as individuals become older, the frequency of anemia increases. while the cause of anemia in many cases can be determined and corrected, in a number of individuals there is no correctable cause found and the patient must live with their anemia. this is known as idiopathic anemia, and can have serious consequences for the individual. numerous studies have demonstrated that anemia is associated with loss of energy and stamina, causing individuals to decrease their activities, which adversely affects both their sense of well-being as well as their physical strength. losses in these areas are associated with the clinical manifestations of frailty. the current pilot study will examine whether or not administration of epoetin alfa, a hormone stimulating production of red blood cells, can reverse this type of anemia. we will examine the consequences of reversing the anemia in terms of physical strength and function, cardiovascular function and sense of well-being and mental function. in this study, individuals with anemia will be treated for six months with epoetin alfa following the correction of their anemia and measurements done to evaluate physical strength, performance, cardiac, mental and kidney function. at the end of treatment, individuals will be followed for an additional six months to determine whether the anemia recurs and physical function decreases. participation in this study is voluntary. all testing and medication received are free to the participant.

Eligibility criteria:
inclusion criteria: * 70 years of age or older * diagnosed with anemia * hemoglobin level less than or equal to 11 * able to perform most activities of daily living without restriction exclusion criteria: * history of serious heart, liver or kidney disease * cancer treated within the last year except for skin cancer (excluding melanoma) * problems with your immune system * received epoetin alfa within the last year

Keywords: anemia frailty epoetin erythropoietin epo
role of pregabalin in treatment of post-op pain in fracture patients

Conditions: Post-operative Pain

Summary: this is a randomized, prospective, double-blind pilot study designed to evaluate the potential effectiveness of pregabalin in post-operative pain management for patients who have sustained a fracture.

on admission, all patients who have sustained orthopaedic injuries of any type, including pelvis, will be screened. however, only those patients who will undergo a single episode of surgery during this hospitalization to surgically repair only one of their orthopaedic fractures will be interviewed by a clinical research nurse. if the patient meets all criteria for inclusion/exclusion in the study, the attending physician will consent the patient for inclusion in the study. upon enrollment into the study, the clinical research nurse will obtain a thorough history from the patient concerning prior narcotic use, response to painful events in the past and will record details of the injury. prior to surgery, the patient will be treated with narcotic pain medication as required in the judgment of the attending physician. the patient will then be randomized before surgery into a placebo group or pregabalin group. the attending physician will be blinded as to which study arm the patient is in. two hours before surgery, patients will receive 75mg of pregabalin. patients will be placed on a patient-controlled anesthesia pump (pca) for 24 hours. on post-operative day one, the patients will be switched to oral oxycodone as needed with supplementation with iv demerol for breakthrough pain. in addition, patients will receive either pregabalin 75mg orally (po) bid, pregabalin 150mg po bid or placebo beginning on the day of surgery until discharge. the clinical research nurse will complete a form which records the daily use of each of the post-operative pain medications. she will also ask the patient to complete a visual analog scale (vas) to assess pain each day while in the hospital. upon discharge, the patient will be given study medication (pregabalin, 75mg po bid, 150mg po bid or placebo). rescue medications will be allowed during the study (including post-operative and outpatient periods). outpatient rescue medications will consist of hydrocodone/acetamenophen (apap) 7.5mg po every sic hours (q6h) as needed (prn). patients will be followed for three months as an outpatient.

Eligibility criteria:
inclusion criteria: * fractures requiring operative treatment during a single operative episode * adult patients between the ages of 19 and 70 exclusion criteria: * prior medical history of narcotic abuse or narcotic use within 2 weeks of injury (except those given in hospital) * contraindications to pregabalin or narcotic analgesics * significant closed head injury * psychiatric illness requiring medical treatment * surgery for other injuries (splenectomy, etc) * history of seizures requiring current anticonvulsant therapy * inability or unwillingness to give informed consent

Keywords: post-operative pain fracture patients pregabalin lyrica
tcf7l2 polymorphisms influence on glycemic control in icu patients with organ failure

Conditions: Genetic Predisposition to Disease; Hyperglycemia; Intensive Care Unit Syndrome; Multiple Organ Failure

Summary: this study evaluates the link between genetic polymorphisms as r7903146, rs12255372 of tcf7l2 gene and the risk of developing hyperglycemia during intensive care unit stay


Eligibility criteria:
inclusion criteria: * admission in icu\>48h * at least one organ dysfunction exclusion criteria: * age\< 18 years * pregnant women * admission less than 48h

Keywords: hyperglycemia multiple organ failure biobank diabetes
follicle activation by inhibition of the hippo pathway

Conditions: Infertility

Summary: the aim of this project is to activate recruitment and growth of resting primordial follicles in the ovaries of women with diminished ovarian reserve, in attempt to increase the chance to become pregnant, either naturally or after assisted reproduction.

for this study investigators will carefully select 20 women with low amh and imminent poi. they will be randomized to have cortical ovarian biopsies taken from either the left or right ovary. the biopsies will be fragmented in 1x1 mm2 pieces and immediately auto-transplanted in a peritoneal pocket under the right ovary. the contralateral untouched ovary will act as the control, making each woman their own control. follow up: each week in 2,5 months the women will be assessed by transvaginal ultrasound and hormonal status. after 2,5-6 months the women will receive a fsh stimulation cycle (rfsh 300 iu or corifollitropin) followed by standard ivf/icsi, hypothesis: the ovaries contain a pool of resting primordial follicles. by fragmentation of cortical ovarian tissue, manipulation of the local environment in the tissue will inhibit the hippo pathway and hereby active recruitment and growth of primordial follicles.

Eligibility criteria:
inclusion criteria: * infertility with indication for ivf/icsi * imminent poi, still cycling * age 25 - 39 years * two ovaries * serum amh measurements \< 5 pmol/l (two independent measurements) * antral follicle count (afc) (sum of both ovaries \< 5) exclusion criteria: * ovarian pathology (endometriosis, cysts) * known chromosomal abnormality * known autoimmune disease (except tpo-antibodies) * patients who have contraindication for laparoscopy

Keywords: iva hippo pathway follicle activation low responder poi poor ovarian reserve poor ovarian response salvador/warts/hippo pathway
circulating micrornas as novel prognosis biomarkers for rheumatoid arthritis

Conditions: Rh Disease

Summary: the correlation of circulating serum mir-125ba and mir-146a expression and clinical response to green tea therapy were analysed in ra patients.clinical response to green tea therapy for 24 weeks was calculated from das28 scores. whereas , a decrease of 1.2 points or above in das28 scores at 24 weeks of treatment compared with baseline was defined as clinical response according to the eular response criteria.a ready-made solutions containing the primers and probes for human mir-146a and mir-125ba (applied biosystems, foster city, ca) and real-time rt-pcr was estimated using an abi 7300 system (applied bio systems).

1. participants: a total of 100 subjects (aged 18-65 years) who were diagnosed as ra with moderate to severe activity at the division of rheumatology and clinical immunology at mansoura university were evaluated in this study. 2. patients were evaluated for therapeutic response at baseline and 12, and 24 weeks of green tea therapy. all patients with ra were subjected for estimation of esr, crp, disease activity score in 28 joints (das28), patient's global assessment (pga), and health assessment questionnaire damage index (haq-di) at each visits (0 week, 12 weeks, and 24 weeks). 3. pain intensity was assessed by using a standard vas of 100 mm previously validated to chronic and acute pains. 4. clinical response to green tea therapy for 24 weeks was calculated from das28 scores. 5. human mir-146a and mir-125ba were isolated and subjected to rt-pcr analysis

Eligibility criteria:
inclusion criteria: * subjects (aged 18-65 years) who were diagnosed as ra with moderate to severe activity at the division of rheumatology and clinical immunology at mansoura university, between 20 january/2015 and 20 september 2015 were recruited in this prospective study. * according to the diagnostic criteria of the american college of rheumatology (arnett et al., 1988), all patients classified as showing established ra for more than 8 years. * only patients who had higher scores of das28-esr, ra biomarkers, and established radiographic analysis, and were diagnosed with ra according to the 2010acr/ eular classification criteria were included in this study. exclusion criteria: • patients who received non-steroidal anti-inflammatory drugs, oral glucocorticoids, had a history of severe deformation of joint, pregnant or lactating women were excluded from this study.
scalp infiltration with diprospan plus ropivacaine for postoperative pain after craniotomy in adults

Conditions: Pain, Postoperative; Post-Craniotomy Headache

Summary: pain is common for the first 2 days after major craniotomy. a majority of patients would suffer from moderate-to-severe postoperative pain after undergoing craniotomy. inadequate analgesia induced sympathetically mediated hypertension may lead to an increased risk for post-operative complications, such as arterial hypertension, intracranial hemorrhage, prolonged hospital stay, and mortality. adequate pain control is essential for patients' prognosis and their postoperative life quality. pain after craniotomy derives from the scalp and pericranial muscles. local anesthetics administered around the incision have been performed clinically. however, some studies revealed that the analgesic effect of local anesthetics was not unsatisfactory due to its short pain relief duration. pain is common for the first 2 days after major elective intracranial surgery, and the relatively short analgesic time of scalp infiltration does not seem to meet the requirements of craniotomy. steroid such as diprospan as an adjuvant to local anesthetics intra-articular injected locally ameliorated pain intensity in knee osteoarthritis or in total knee arthroplasty. however, there has not been reported about local application of diprospan on scalp infiltration. thus, the investigators suppose that pre-emptive scalp infiltration with steroid (diprospan) plus local anesthetic (ropivacaine) could relieve postoperative pain after craniotomy in adults.


Eligibility criteria:
inclusion criteria: * patients scheduled for elective craniotomy for resection of tumour under general anaesthesia; * american society of anesthesiologists (asa) physical status of i , ii or iii; * participates with an anticipated fully recovery within 2 hours postoperatively. exclusion criteria: * history of craniotomy; * expected delayed extubation or no plan to extubate; * participants who cannot use a patient-controlled analgesia (pca) device; * participants who cannot understand the instructions of a numeral rating scale (nrs) 35 before surgery; * extreme body mass index (bmi) (\ 35); * allergy to opioids, diprospan or ropivacaine; * history of excessive alcohol or drug abuse, chronic opioid use (more than 2 weeks), or use of drugs with confirmed or suspected sedative or analgesic effects; * history of psychiatric disorders, uncontrolled epilepsy or chronic headache; * pregnant or at breastfeeding; * symptomatic cardiopulmonary, renal, or liver dysfunction or history of diabetes; * preoperative glasgow coma scale\< 15; * suspicion of intracranial hypertension; * peri-incisional infection; * participants who have received radiation therapy and chemotherapy preoperatively or with a high probability to require a postoperative radiation therapy and chemotherapy according to the preoperative imaging.

Keywords: postoperative pain; post-craniotomy headache ropivacaine pre-emptive scalp infiltration diprospan
the effect of education given with creative drama method based on leininger's theory on the cultural sensitivity and effectiveness levels of nursing students

Conditions: Nursing Education; Nursing Students; Creative Drama; Cultural Sensitivity

Summary: this study aims to determine the effect of cultural care education given with creative drama method according to leininger theory on the cultural sensitivity and effectiveness levels of nursing students. the study will be conducted as a pre-test and post-test randomized controlled experimental study. the universe of the study consists of fourth-year students (n=80) of "agri ibrahim cecen university, faculty of health sciences, department of nursing". in this study, students in the intervention and control groups will be determined by simple randomization method. after the theoretical course content is given based on leininger theory, students in the intervention group will be given creative drama technique with cases and students in the control group will be given traditional case examples. a pre-test will be applied before the training program and a post-test will be applied after the training program.


Eligibility criteria:
inclusion criteria: * want to participate in the study voluntarily, * have taken the intercultural nursing course, * have taken 75% of the practical nursing courses. exclusion criteria: * being a nurse working in the clinic, * being a foreign national, * being in the initiative group and not participating in the creative drama application, * the student wanting to leave the research at any stage, * not filling out the data collection forms or filling them incompletely.

Keywords: leininger nursing students creative drama cultural sensitivity cultural effectiveness
effectiveness of garlic oil in the treatment of arsenical palmer keratosis

Conditions: Chronic Arsenic Poisoning

Summary: twenty patients of mild to moderate degree of arsenical palmer keratosis will be treated with garlic oil capsule orally for 12 weeks to examine its effectiveness in reducing body arsenic load and clinical symptoms. similar treatment with similar number of arsenic exposed controls and healthy volunteers will be included for comparison.

thousands of bangladeshi are suffering from arsenic-induced keratosis affecting palms and soles. palmer keratosis, particularly in young female, affects the socioeconomic condition. till today there is no effective treatment. twenty patients of mild to moderate degree of arsenical palmer keratosis will be treated with garlic oil in soft capsule (10 mg/day) orally for 12 weeks. similar treatment will be given to 20 arsenic exposed controls and 20 healthy volunteers for comparison. the aim of this study is to examine the effectiveness of oral administration of garlic oil to reduce body arsenic load and clinical symptoms of arsenical palmer keratosis.

Eligibility criteria:
inclusion criteria (patients): * history of taking arsenic contaminated water (\>50 ppb) for more than 6 months * patients having mild to moderate arsenical keratosis present on palm of the hand * patients those voluntarily agree to participate inclusion criteria (arsenic exposed controls): * family member of the patient * drinking arsenic contaminated water from the same source as patient * those voluntarily agree to participate * no sign/symptom of palmer keratosis inclusion criteria (healthy volunteers): * drinking arsenic safe water (\<50 ppb) * those voluntarily agree to participate exclusion criteria: * pregnancy * lactating mother * patient receiving treatment of arsenicosis * any other chronic disease like tuberculosis, diabetes mellitus, bronchial asthma

Keywords: arsenic arsenicosis garlic oil keratosis
external shoe lift to improve healing and adherence in patients with diabetic foot ulcers

Conditions: Diabetic Foot Ulcer; Peripheral Neuropathy; Treatment Adherence and Compliance

Summary: previous researches hipothesize that imposed limb-length discrepancies may discourage adherence in patients with active diabetic foot ulcer and using offloading devices. our hipothesis is that the use of an external shoe lift contralaterally to the affected foot may improve adherence to offloading devices and improve healing.


Eligibility criteria:
inclusion criteria: * plantar diabetic foot ulcer. * wagner i and ii classification. * ulcer area between 1-30 cm square centimeters. * hba1c values in the last three months below 11% * ankle brachial index (abi) value \> 0.5. exclusion criteria: * diagnosis of critical limb ischaemia definid by tascc ii guideline. * presence of foot ulcer in both feet. * presence of soft tissue infection. * osteomyelitis suspicion. * peripheral neuropathy due to different causes than diabetes.
air versus gas tamponade in primary retinal detachment

Conditions: Retinal Detachment; Proliferative Vitreoretinopathy

Summary: management of primary retinal detachment due to upper retinal break is one of controversial situation that may face ophthalmologists in vitreoretinal subspecialty.

there is no single surgical plan for management of primary retinal detachment due to upper retinal break, some surgeons prefer scleral buckling over vitrectomy in cases with no traction over the retinal break, others prefer to perform primary pars-plana vitrectomy with either air or gas tamponade. in this study we aim to compare the results of air and non-expansile gas tamponade in cases with upper retinal detachment with grade a or b proliferative vitreoretinopathy.

Eligibility criteria:
inclusion criteria: * primary rhegmatogenous retinal detachment with upper break with proliferative vitreoretinopathy from grade a to b. exclusion criteria: * cases with combined tractional retinal detachment. * cases with recurrent retinal detachment. * cases that are eligible for scleral buckling that have no traction on retinal break.

Keywords: vitrectomy retinal detachment
the effect of progressive relaxation exercise on nurses

Conditions: Progressive Relaxation Exercise; Comfort; Life Satisfaction; Burnout

Summary: this study aims to examine the effect of progressive relaxation exercise on nurses' life satisfaction, comfort and burnout levels. data will be collected by using descriptive characteristics information form, satisfaction with life scale, nurse comfort scale and burnout scale. the nurses in the intervention group will be asked to perform relaxation exercises. the nurses in the control group will not receive any intervention.

this study aims to examine the effect of progressive relaxation exercise on nurses' life satisfaction, comfort and burnout levels. this study will be conducted as a randomized controlled experimental study. data will be collected by using descriptive characteristics information form, satisfaction with life scale, nurse comfort scale and burnout scale. the nurses in the intervention group will be asked to perform relaxation exercises 3 days a week for 5 weeks, 20 minutes in each practice. the nurses in the control group will not receive any intervention.

Eligibility criteria:
inclusion criteria: working as a nurse in a tertiary treatment center for at least 3 years have not participated in any relaxation exercise absence of neurological/psychiatric disorders not having an obstacle to exercise nurses who volunteered to participate in the study will be included in the study. exclusion criteria: individuals who have any exercise program and use any relaxation method (yoga, acupuncture, massage, music therapy, etc.) will not be included in the study.