Kornimate/medical-research-clean huggingface dataset:
antibiotic profile of pathogenic bacteria isolated in public hospitals in northern jordan

Conditions: Bacterial Infections; Antibiotic Resistant Infection; Surgical Site Infection

Summary: the main aim of the study was to identify the various pathogens associated with surgical site infections and their antibiotic susceptibility in a governmental hospital in northern jordan.

background: surgical site infections are hospital-acquired, vary from one hospital to another, and can cause significant postoperative morbidity, mortality, and prolonged hospital stay. aim: the main aim of the study was to identify the various pathogens associated with surgical site infections and their antibiotic susceptibility in a governmental hospital in northern jordan. methods: postsurgical wound samples were collected and processed in a microbiology laboratory using standard microbiological techniques. antibiotic susceptibility tests were performed using 13 antibiotics covering the gram-positive and gram-negative bacteria using the disc diffusion test.

Eligibility criteria:
inclusion criteria: * post-surgical wound infection exclusion criteria: -

Keywords: antimicrobial hospital post-surgical infection surgery
health literacy among caregivers of children with ige-mediated allergy with risk of anaphylaxis

Conditions: Health Literacy; Anaphylaxis

Summary: research on health literacy among caregivers of children with ige-mediated allergy at risk of anaphylaxis (life-threatening allergic reaction). health literacy is a person's ability to understand health information so that they can maintain or improve their health and quality of life (of themself and children). the aim of the study is to test the general knowledge of anaphylaxis. furthermore we test the extent to which caregivers consider themselves able to recognize and to treat anaphylaxis.


Eligibility criteria:
inclusion criteria: * caregivers of children with ige-mediated allergy with risk of anaphylaxis (adults, grandparents, school caregivers etc.). * minimum 18 years old. * signed informed consent exclusion criteria: * none
a prospective registry of patients with congenital penile anomalies

Conditions: Concealed Penis; Hypospadias; Phimosis; Chordee

Summary: prospective registry and biobank in pediatric patients with congenital penile anomalies

according to the u.s. center for disease control and prevention, in the united states, one in 200 babies is born with congenital penile anomalies. in korea, there is a rapid increase rate among other types of congenital anomalies from 1993 to 2010, from 0.7 to 10,000 to 9.9 per 10,000 cases. it leaves long term sequelae into adulthood even after the corrective operation has been performed. some of the sequelae that patients experienced were difficulties in micturition, dissatisfaction with the appearance of the penis, and decreased sexual function, as well as psychosexual well-being. despite its high prevalence, hypospadias and related penile anomalies have no specific known etiology and mechanisms. however, numerous studies have shown that both gene and environment play a significant role in making etiologies multifactorial. furthermore, a molecular trial shows that both genetics and environmental factors disrupt the normal development course of the phallus, or penis. penis formation, growth, or the formation of the male urogenital system, in general, have shown to be androgen dependent. any defect in the androgen synthesis leading to androgen deficiency or receptors may play a role, specifically, in the development of penile anomalies. pediatric patients between the ages of 0 to 18 years, with congenital penile anomalies and scheduled to undergo penoplasty will be enrolled. in this prospective observational study, our aims are to collect dartos fascia, which is a tissue in penile region, and examine histochemistry of the sample.

Eligibility criteria:
inclusion criteria: * those with congenital penile anomalies (e.g. hypospadias, chordee, webbed penis) and receiving penoplasty at the institution. * those who understand the registry's content and are signed and dated by the patient (or the patient's legal guardian or representative). exclusion criteria: * those who are unwilling to participate and do not sign the informed consent. * unable to read or understand korean.
blood and tissue sample collection for future colon cancer biomarker studies in patients undergoing colonoscopy

Conditions: Colorectal Cancer; Health Status Unknown

Summary: rationale: collecting and storing samples of blood and tissue from patients undergoing colonoscopy to study in the laboratory may help doctors learn more about colon cancer and identify biomarkers related to colon cancer in the future. purpose: this laboratory study is collecting blood and tissue samples for future colon cancer biomarker studies in patients undergoing colonoscopy.

objectives: * collect blood and tissue samples (including polyps, abnormal growths, cancer, and normal tissue) from patients undergoing colonoscopy. outline: patients undergo blood and tissue sample collection during colonoscopy. samples are stored for future biomarker proteomic profiling.

Eligibility criteria:
disease characteristics: * scheduled for colonoscopy as routine screening or for a specific problem patient characteristics: * not pregnant prior concurrent therapy: * no concurrent participation in a clinical trial to treat cancer or prevent cancer recurrence

Keywords: colon cancer health status unknown
efficacy, safety, and pharmacokinetics of qaw039

Conditions: Persistent Asthma

Summary: this study will assess the safety, efficacy and pharmacokinetics of qaw039 in steroid-free patients with mild to moderate persistent asthma.


Eligibility criteria:
inclusion criteria: * patients with a medical history of mild to moderate persistent allergic asthma. * patients must weigh at least 45 kg to participate in the study, and must have abody mass index (bmi) of \>17 kg/m2. * female patients must be surgically sterilized, postmenopausal or using a double-barrier method of contraception exclusion criteria: * women of child-bearing potential. * smokers defined as history of smoking in the previous 6 months or a smoking history of more than 10 pack years, a pack year being defined as smoking the equivalent of 20 cigarettes - a pack - every day for the period of 1 year * patients with severe persistent asthma other protocol-defined inclusion/exclusion criteria may apply.

Keywords: asthma
alternative and integrative therapy for lumbar disk herniation

Conditions: Sciatica; Intervertebral Disc Disorder

Summary: the investigators report management of lumbar disc herniation with severe sciatic pain using an integrative complementary and alternative medicine approach with a 5 year follow-up.


Eligibility criteria:
inclusion criteria: * lbp with sciatica, * a numeral rating scale (nrs) leg pain intensity of 5 or higher * onset within 1 year; * lumbar disk heriation confirmed by mri; * written consent to attend 6 months of integrative cam treatment and following assessment visits. exclusion criteria: * treatment regarding the current lbp and/or sciatica (e.g. surgery, nerve block, or analgesic medication) other than the cam treatment specified in the protocol * non-spinal or soft tissue problem related to back pain or sciatica (e.g. pregnancy, spinal tumor, or rheumatoid arthritis) * history of spinal surgery, vertebral dislocation, fracture, or cancer;
impact of systematic nursing guidance on the psychological effects of parents of children with cardiac catheterization.

Conditions: Educational Videos; Catheterization; Congenital Heart Disease in Children; Parental Uncertainty; Parental Anxiety

Summary: to examine if adding educational digital video disk to routine education can reduce parental uncertainty and anxiety more if their children undergo congenital heart disease catheterization and when catheterization or post- catheterization complications occur. we want to know, compared to only routine education, if adding digital video disk could decrease parental uncertainty or anxiety more or not.

aims and objectives: to examine if adding educational digital video disk to routine education can reduce parental uncertainty and anxiety more if their children undergo congenital heart disease catheterization and when catheterization or post- catheterization complications occur. background: parents experience uncertainty and anxiety when their children undergo conditions mentioned above. design: a randomized control-group pretest-posttest design. methods: in a teaching hospital, 50 fathers and 50 mothers whose children (n=50) underwent first elective catheterization for congenital heart disease were randomly divided into group 1: 25 fathers and 25 mothers receiving routine education plus digital video disk before catheterization; and group 2: 25 fathers and 25 mothers receiving routine education before catheterization. between groups, parental uncertainty and anxiety levels were compared (1) before education, (2) after education (before catheterization) and (3) on the discharge day (after catheterization). among mothers whose children had catheterization or post- catheterization complications, the effect of watching the digital video disk on uncertainty and anxiety at discharge day was evaluated.

Eligibility criteria:
inclusion criteria: * parents whose children underwent first elective cardiac catheterization for congenital heart disease * parents should have been the primary caregivers * parents able to communicate effectively, either orally or in writing exclusion criteria: * parents of children with genetic disorders * parents of children with non-cardiac congenital anomalies * parents of children with diseases such as cerebral palsy, epilepsy, psychiatric diseases, and chronic lung diseases
anesthesia on gut microbiota and metabolomics

Conditions: Hepatic Tumor Resection

Summary: hepatectomies are performed for the treatment of hepatic tumors and livingdonor liver transplantation. the success of liver resection relies on the remnant liver's ability to regenerate after major tissue loss. despite appropriate liver remnant volume after resection ensures the liver's ability to regenerate, regeneration progresses at variable ratesin patients. many researches have established a relationship between the gut microbiome and patients with liver disease such as liver cirrhosis, alcoholic liver disease and obesity related liver diseases. these liver disorders are associated with bacterial overgrowth, dysbiosis, and increased intestinal permeability. however, the relationship between hepatectomy and microbiota has not been fully investigated. the measurement of small-molecule metabolites has been an integral part of clinical practice including the familiar clinical standards like glucose and creatinine. metabolomics, however, is able to measure all the metabolites at once. it is possible to get a far more comprehensive picture of what is happening to a patient's physiology or metabolism. although gut microbiota has been shown to be related to liver disease and liver regeneration. obtaining a more comprehensive analysis by identifying not only the microbial composition but also the metabolites will be more insightful. many routine perioperative aspects of surgical care can impact the state of the microbiome and therefore can impact clinical outcomes, like bowel preparation and antibiotics. potential factors affecting the gut microbiota also include perioperative manipulation, stress released hormones, and opioids. maintenance of proper anesthetic depth is beneficial to attenuate surgical stress. general anesthesia including volatile anesthetics and opioids, is associated with altered gut microbiota which might in turn affect liver regeneration. in this regard, perioperative care such as anesthesia, is one of the key points for the success of a liver resection. however, which anesthetic method is preferable regarding postoperative outcome or recovery is controversial. in this study, the study population will include liver tumor resection and living donor hepatectomy. we aimed to 1) identify the relationship of hepatectomy and changes of gut microbiota and metabolomics. 2) investigate the impact of different anesthetic methods on the interaction of gut microbiota and metabolomics.


Eligibility criteria:
inclusion criteria: 1. expected to receive hepatic tumor resection in national taiwan university hospital, age between 20 and 75 years old. exclusion criteria: 1. previous use of antibiotics within four weeks. 2. previous gastrointestinal surgery.

Keywords: hepatectomy microbiota metabolomics anesthetic
safety and efficacy of remote ischemic conditioning combined edas on ischemic moyamoya disease

Conditions: Moyamoya Disease

Summary: encephaloduroarteriosynangiosis (edas) is widely used as an indirect technique for treatment of moyamoya disease. nevertheless, this indirect surgery tends to establish insufficient collateral circulation in most adult mmd patients. nowadays, there is a lack of adjuvant therapies for improving collateral circulation induced by indirect revascularization. this study aims to explore whether remote ischemic conditioning can improve the collateral circulation after indirect revascularization.

encephaloduroarteriosynangiosis (edas) is widely used as an indirect technique for treatment of moyamoya disease. nevertheless, this indirect surgery tends to establish insufficient collateral circulation in most adult mmd patients. nowadays, there is a lack of adjuvant therapies for improving collateral circulation induced by indirect revascularization. remote ischemic conditioning (ric) is a noninvasive approach protecting the brain by inflating and deflating blood-pressure cuff placed on the upper limbs. it has been confirmed to improve cerebral perfusion by promoting angiogenesis and arteriogenesis in ischemic animal brain. in addition, daily remote ischemic conditioning is a promising technique to ameliorate chronic cerebrovascular disease like intracranial atherosclerotic stenosis, small-vessel disease. thus, this study aims to explore whether remote ischemic conditioning can improve the collateral circulation after indirect revascularization.

Eligibility criteria:
inclusion criteria: 1. subjects who were diagnosed as moyamoya disease by the diagnostic criteria recommended by the research committee on mmd of the ministry of health and welfare of japan in 2012. 2. suzuki stage: 2-5 stage 3. age: between 18 and 65 years old 4. subjects present with ischemic stroke or transient ischemic attack. 5. subjects who plan to accept the first edas surgery. 6. informed consent obtained from patient or patient's surrogate exclusion criteria: 1. acute ischemic stroke occurred within one month. 2. suffered intracranial hemorrhage before 3. subjects with large infarction spread widely over the territory of a main arterial trunk 4. aneurysms in the main arterial trunk 5. severe cardiac diseases like atrial fibrillation，valvular disease，heart failure, infective endocarditis and so on. 6. malignant tumors or severe disordered function of the heart, lung, liver or kidney. 7. severe hemostatic disorder or severe coagulation dysfunction. 8. uncontrolled diabetes mellitus with a serum fasting blood glucose level\>300 mg/dl, or requires insulin; hypertension with a systolic blood pressure over 180 mmhg or a diastolic blood pressure over 110 mmhg. 9. severe injury on upper limbs. 10. pregnant or lactating women. 11. life expectancy is less than 3 years. 12. patients who are not suitable for this trial considered by researchers for other reasons

Keywords: moyamoya disease edas remote ischemic conditioning cerebral blood flow
whey-based partially hydrolyzed formula versus polymeric formula on undernourished neurologically impaired children: open-labelled randomized study

Conditions: Nutrition Disorder, Child; Neurologic Disorder

Summary: purpose: undernutrition is common in neurologically impaired children. it increases the burden of comorbidities and affects the quality of life of these children. this study aimed primarily to compare the efficacy of whey-based partially hydrolyzed formula (wphf) versus isocaloric polymeric formula on the nutritional status reflected by growth parameters and feeding tolerance in undernourished children with neurological impairment (ni). the secondary aim was to follow up on the changes in these parameters after using wphf for 3 and 6 months

this prospective open-label randomized study was conducted over 6 months on children with ni aged 2- 6 years. patients were divided into two groups: one group received 50% of their caloric requirements as isocaloric polymeric formula (standard ) and 50% standard nutritional feeding according to espghan guidelines (group i), the second group received 50% of their caloric requirements as wphf, and the other 50% standard nutritional feeding according to espghan guidelines (group ii). at the start of the study, detailed clinical and nutritional history was recorded for all children in the two groups. anthropometric measurements were measured, and the z score was calculated for all parameters. symptoms of feeding intolerance and frequency of chest infections were assessed and reported. these parameters were reassessed after 3 months and 6 months of nutritional intervention and compared between the two groups.

Eligibility criteria:
inclusion criteria: 1. children aged from 2-6 years 2. undernourished children with ni (1 or more of the following signs for identification of undernutrition in the studied children: * weight for age z score \<-2, * triceps skinfold thickness \<10th centile for age, * mid-upper arm fat or muscle area \<10th percentile for age, * faltering weight * failure to thrive. * physical signs of undernutrition such as decubitus skin problems and poor peripheral circulation exclusion criteria: * ni due to metabolic diseases

Keywords: neurological impairment children partially hydrolyzed formula
the effects of time points to cease parenteral nutrition and igf-1 on very low birth weight infants

Conditions: Growth Retardation

Summary: this study aims to estimate short-term and long-term effects of time points to cease parenteral nutrition on very preterm infants, such as growth; to estimate the role of insulin-like growth factor 1 in the growth.

at present, it is unclear when to cease parenteral nutrition, the effects of cessation times on preterm infants' growth, and whether insulin-like growth factor 1 (igf-1) has a mediation effect in the procedure that nutrients regulate the growth in preterm infants. therefore, a prospective cohort study was designed with the aims: 1. to estimate the association between the time to cease parenteral nutrition and the growth in very low birth weight; 2. to investigate the relationship between nutrient volume in parenteral nutrition and growth in very low birth weight; 3. to analyze the igf-1 mediation effect between nutrient volume and growth regulations.

Eligibility criteria:
inclusion criteria: 1. infants with a birth weight less than 1500 grams 2. infants admitted within 72 hours after birth 3. infants born from july 1, 2023, to june 30, 2024 4. written informed consent from parents or guardians exclusion criteria: 1. infants with congenital abnormality 2. infants surviving \<7 days after birth
evaluate safety & immunogenicity of 2 or 3 doses of gsk hrv vaccine in healthy infants in south africa

Conditions: Infections, Rotavirus

Summary: the purpose of this study is to determine the appropriate regimen of gsk hrv vaccine for concomitant administration with epi vaccines to infants in south africa.


Eligibility criteria:
inclusion criteria: * healthy infants born after a normal gestation period (\>=36 weeks), between 5 and 10 weeks of age at dose 1 with confirmed negative hiv status of the subject's mother. * written informed consent was obtained from the parent/guardian of the subject before study entry. exclusion criteria: * history of allergic disease/polio disease, * confirmed or suspected immunosuppressive or immunodeficient condition, * clinically significant history of chronic gastrointestinal disease or other serious medical condition as determined by the investigator, * received treatment prohibited by the protocol. * any confirmed or suspected immunosuppressive or immunodeficient condition, including human immunodeficiency virus (hiv) infection.
patient preferences for precision medicine: determining optimal patient quality of life using parpi's

Conditions: Ovarian Cancer; Quality of Life

Summary: patients with ovarian cancer with defective dna repair mechanisms derive substantial benefit from parp inhibitor (parpi) maintenance therapy. both niraparib and olaparib are effective inhibitors of parp, which exploit already defective dna repair mechanisms (e.g., via brca mutations), particularly those with homologous recombination deficiency (hrd). these two parpis have notably different toxicity profiles, with niraparib showing many more severe side effects. in this ovarian cancer canada funded study, we will implement perform hrd testing for ovarian cancer patients in saskatchewan with response to platinum-based chemotherapy. this information will provide personalized and precision estimates about the amount of benefit that can be expected from taking a parpi. we will evaluate both treatment outcomes and quality of life in a real-world study setting, to inform future decision-making regarding efficacy, quality of life and cost-effectiveness of parpi therapy, specifically for niraparib. we hypothesize that for patients who are homologous recombinant proficient (hrp), the median 32.7-month incremental benefit (in delaying cancer progression) from taking a parpi (niraparib is the only parpi approved in this setting) will not be seen as being value-add when balanced by the decreased quality of life that accompanies the first 6-12 weeks of therapy. we also hypothesize that for women who are hrp, that parpi therapy will not be cost-efficient.


Eligibility criteria:
inclusion criteria: * known or suspected stage 3/4 high grade serous or endometrioid ovarian cancer able to provide oral consent and complete questionnaires in english as per study protocol exclusion criteria: * ineligible for maintenace parpi therapy refusal to undergo hrd testing

Keywords: parpi hrd testing
impact of n-3 polyunsaturated fatty acids in a protein-enriched diet with low gi in type 2 diabetes patients

Conditions: Overweight; Obese; Insulin Resistance; Diabetes

Summary: type 2 diabetes is tightly associated with overweight and obesity. inflammatory processes are crucial triggers for insulin resistance that paves the way to type 2 diabetes. in a previous study the investigators have shown that n-3 polyunsaturated fatty acids diminish adipose tissue inflammation in morbidly obese non-diabetic subjects. in this observational study the investigators will apply n-3 polyunsaturated fatty acids as addition to a protein-enriched diet with low glycemic index to overweight and obese patients with insulin resistance, prediabetes and manifest type 2 diabetes over up to 6 months. primary efficacy parameters are changes from baseline in hba1c and body weight for for type 2 diabetes and all other patients, respectively.


Eligibility criteria:
inclusion criteria: * overweight or obesity and * insulin resistant or pre-diabetes or type 2 diabetes exclusion criteria: * changes in anti-diabetic medication in the lat two months * acute illness during the last two weeks * hiv infection * hepatitis of other clinically significant hepatic disease other than non-alcoholic hepatic steatosis * severe or insufficiently treated cardiovascular, renal (gfr-mdrd \< 60 ml/min) or pulmonary disease * macroproteinuria (\> 300 mg/g creatinine) * clinically significant or insufficiently treated thyroid disease * anemia * active malignant disease * inborn or acquired coagulopathy

Keywords: observational study