Kornimate/medical-research-clean huggingface dataset:
is fluidotherapy effective in rheumatoid hand?

Conditions: Rheumatoid Arthritis

Summary: the objective of this study is to evaluate the efficacy of fluidotherapy primarily on function and quality of life, secondarily on pain, morning stiffness, grip strength, and disease activity in patients with rheumatoid hand.ninety-three patients were enrolled in this prospective, single-blind, randomized, and controlled trial. patients were randomized into 2 groups. group 1 (n=47) had fluidotherapy (5 times per week, for 3-week duration) and group 2 (n=46) was the control group. all patients received joint protection and exercise program. the primary outcome measures were health assessment questionnaire (haq) and duruöz hand index (dhi) and secondary outcome measures were pain and morning stiffness assessed using the visual analog scale (vas, 0-100 mm), the grip ability test (gat), disease activity score-28 (das-28), and grip strength. these assessments were performed at baseline, at week 3 and week 12 after treatment.


Eligibility criteria:
inclusion criteria: * age between 18-75 years ra diagnosis fulfilling acr 2010 criteria * disease duration for at least 6 months * no high disease activity and no acute arthritis in the hand according to das-28 * hand problem specified with pain and loss of function in the hand * being in an eligible sociocultural and socioeconomic state so as to be able to come to the ambulatory treatment program exclusion criteria: * change of medication within the last 3 months or during the study (except for non-steroidal anti-inflammatory drugs and paracetamol) * changes in oral corticosteroid dose in the last month, intraarticular or intramuscular corticosteroid use * hand or upper extremity surgery in the last 6 months * previous injury in the hand or upper extremity in the last 6 months * pregnancy * presence of sensory defects in the hand * presence of cognitive and/or psychiatric disease * physical therapy for the hand in the last 3 months.

Keywords: rheumatoid hand fluidotherapy rehabilitation
diagnostic value of dwi-mri for detection of peritoneal metastases in high-risk pancreatic ductal adenocarcinoma.

Conditions: Pancreas Cancer, Duct Cell Adenocarcinoma; Pancreas Adenocarcinoma; Peritoneal Metastases; Peritoneal Carcinomatosis

Summary: diffusion-weighted magnetic resonance imaging (dwi/mri) has been described in recent literature as a highly sensitive and specific modality for the detection of peritoneal metastases (pm). it has been demonstrated to be superior to computed tomography (ct) for patients with known peritoneal disease from colorectal and gynaecological malignancies. however, the literature is scarce on the role of dwi/mri in patients with pancreatic ductal-adenocarcinoma (pdac). the aim of this study is to prospectively assess the added value of whole-body dwi/mri (wb-dwi/mri) to ct for detection of pm in the preoperative staging of patients with high-risk pdac and evaluate how it correlates with intraoperative findings.

this is a prospective study from a single center. patients will be evaluated and operated on by one of five surgeons with a subspeciality in hepato-biliary and pancreatic surgery. after thorough assessment for resectability, patients with pdac considered resectable based on ct, but at high-risk for peritoneal disease, will be prospectively included in the study and assessed with wb-dwi/mri within 4 weeks of the planned surgery, with the standard protocol including the following sequences: patients will drink 1l of pineapple juice one hour prior to the examination in order to provide a negative intraluminal contrast. patients will receive 20 mg of intravenous hyoscine butylbromide at the beginning of the mr exam in order to reduce bowel peristalsis. sequences will include axial et coronal t2wi of the abdomen and pelvis, axial dwi with b values of 0, 50 and 1000 of the abdomen and pelvis, as well as pre and post gadolinium-based contrast axial and coronal 3d t1wgre. patients with no evidence of pm on wb-dwi/mri will be operated on and undergo pancreatic resection following the usual exploration of the peritoneal cavity in case of occult metastatic disease. patients with suspicion of pm on wb-dwi/mri will be approached with a diagnostic laparoscopy first, then undergo pancreatic resection if no evidence of pm is found. each case will be followed for at least 6 months.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of pancreatic ductal adenocarcinoma. * resectable disease or borderline resectable disease based on ct. * tumor size ≥ 3 cm. * ca 19-9 ≥ 400 u/ml with normal bilirubin level (\< 40) * no evidence of distant metastases. * patient fit for pancreatic resection (ecog 0 or 1). exclusion criteria: * impossibility to obtain tissue diagnosis preoperatively confirming pancreatic ductal adenocarcinoma. * locally advanced disease on ct. * tumor size \< 3 cm. * ca 19-9 \< 400 u/ml or ca 19-9 ≥ 400 u/ml with no preoperative drainage. * suspicion of distant metastases, including peritoneal metastases, on ct. * patient who is unable to have mri. * patient unfit for pancreatic resection (ecog 2 or more).

Keywords: dwi pdac carcinomatosis diagnostic laparoscopy
cereset for caregivers

Conditions: Glioma

Summary: in this single arm, open label study, investigators will evaluate the feasibility of using the cereset (formerly known as hirrem - high-resolution relational, resonance-based electroencephalic mirroring) intervention for a stressed population confronting an acute burden on their lives - caregivers of newly diagnosed high-grade glioma patients. the cereset intervention is a closed-loop acoustic stimulation intervention that has been studied in patients with ptsd, insomnia, postural orthostatic tachycardia, and military veterans.

primary objective: • to determine the feasibility of completing the prescribed cereset research office intervention for trial participants in this single arm, open label study. secondary objectives * to assess the tolerability of the intervention * to assess changes in trial participant wellbeing and quality of life. * to assess changes in physiological response at pre-intervention and post-intervention time points. exploratory objectives * to assess the utilization of cereset research wearable (portable, limited scope wearable device) after the cro intervention. * to assess the participant acceptability of the cereset research intervention.

Eligibility criteria:
inclusion criteria: * ≥18 years of age * identified as caregiver by patient with glioma as defined as the primary, non-professional, non-paid person who provides the majority of emotional financial and/or physical support. there will only be one trial participant allowed per patient/caregiver dyad. * the trial participant must be caring for a patient who is: * ≥18 years of age * has a histologically confirmed malignancy that is a high grade glioma which includes (astrocytoma, oligodendroglioma, glioblastoma, ependymoma). * any world health organization (who) grade gliomas * trial participant is able to understand and the willingness to sign an irb-approved informed consent document. * trial participant is able to sit in a chair for 90 minutes. exclusion criteria: * trial participant is a heavy alcohol user per the substance abuse and mental health services administration. * heavy alcohol use is defined as binge drinking on 5 or more days in the past month. * binge drinking is defined as 4 drinks for women and 5 drinks for men on the same occasion. * trial participant has severe hearing impairment defined as word discrimination at \<50% with or without the use of hearing aids. * trial participant's weight is greater than or equal to 400 pounds at time of enrollment (chair limit). * prior trial participant use of transcranial magnetic stimulation (tms), transcranial direct current stimulation (tdcs), alpha stimulation, neurofeedback, biofeedback, or deep brain stimulation (dbs) within one month before enrollment. * trial participant has previously used hirrem, or cereset. * trial participant has a known seizure disorder requiring ongoing anti-epileptics prescribed specifically for seizure disorder. * trial participant states he or she will not be able to abstain from daily use of alcohol or recreational drugs during the intervention period.

Keywords: high-grade glioma stress caregivers
evaluation of the efficacy and tolerance of b-back® on the burnout syndrome

Conditions: Efficacy and Tolerance of B-Back® on the Burnout Syndrome

Summary: the purpose of this study is to determine the efficacy and the tolerance of the food supplement b-back®, containing α-casozepine, taurine, eleutherococcus senticosus and extramel®, on the burnout syndrome.

the burnout syndrome currently concern all the professional categories. in 2010 the who estimated that the three countries with the most important work-related depression are unites states, ukraine and france. the direct and indirect costs of work-related stress for the insurance program were not insignificant. the purpose of this study is to determine the efficacy of the food supplement b-back® proposed in order to improved the symptoms of the burnout syndrome : stress, fatigue, emotional imbalance, anxiety, sleep, etc. the main objective is to determine the efficacy of b-back® on the symptoms suggestive of the burnout syndrome by using the burnout measure short version (bms-10). the others objectives were to evaluate the tolerance of the product, to evaluate the efficacy of b-back® on the symptoms suggestive of the burnout syndrome by using the maslach burnout inventory, depression, and the global quality of professional and family life, sleep,and fatigue (energy).

Eligibility criteria:
inclusion criteria: * males and females outpatients aged 30-65 years old * practicing professionals in contact with patients, students,... * symptoms suggestive of burnout syndrome * minimum score to the bms-10 = 4 * able to understand the sdudy documents * agreeing to go to dates of controls * able to give informed consent * affiliated to a french national insurance program exclusion criteria: * current anxiolytic or antidepressant treatment * allergy known about one of the components of the food complement in the study * intolerance in the lactose and in the proteins of milk * pregnancy or feeding * progressive pathology involving life-threatening during study * professional on sick leave * cancer not stabilized for at least five years or considered as not recovered * subjects deprived of liberty court decision * subjects in the psychic incapacity to understand the constraints of the study

Keywords: burnout syndrome depression work-related food supplement
a study to characterize the cardiac phenotype of individuals with friedreich's ataxia (carfa study)

Conditions: Friedreich's Ataxia

Summary: friedreich's ataxia (fa) is an autosomal recessive disease with an incidence of 1/50,000 in the caucasian population. the main manifestations of fa are progressive sensory and cerebellar ataxia and cardiomyopathy (cm). it is the most common form of inherited ataxia. a severe cm affects \~60% of fa patients, mostly young adults, and leads to cardiac failure then death. currently, no therapy can change the course of this severe cardiomyopathy. this study is designed to characterize the cardiac manifestations of fa using cardiac magnetic resonance (cmr), echocardiography, serum cardiac biomarkers and evaluation of fatigue severity, in the context of the neurological disease.


Eligibility criteria:
inclusion criteria (friedreich's ataxia): * males and females; * ≥ 18 years old; * willing and able to provide informed consent; * definitive diagnosis of fa, based on clinical phenotype and genotype; * with a hypertrophic cardiomyopathy; * ability to complete study assessments. exclusion criteria (friedreich's ataxia): * symptoms of cardiac failure; * moderate to severe atrial or ventricular arrhythmias; * history of angina pectoris; * inability to undergo cardiac mri; * clinical history or evidence of diabetes; * abnormal kidney function; * females who are pregnant or nursing; * receipt of an investigational drug within 30 days or 5 half-lives, or active enrollment in an investigational medication or device study; * inability to sit with back support; * inability to undergo exercise test; * inability to comply with all study requirements; * unaffiliated to any french health insurance or equivalent. inclusion criteria (healthy volunteers): * healthy males and females; * ≥ 18 years old; * willing and able to provide informed consent; * age and gender matched to the friedreich's ataxia group; * ability to complete study assessments. exclusion criteria (healthy volunteers): * inability to undergo cardiac mri; * clinical history or evidence of diabetes; * abnormal kidney function; * females who are pregnant or nursing; * receipt of an investigational drug within 30 days or 5 half-lives, or active enrollment in an investigational medication or device study; * inability to undergo exercise test; * inability to comply with all study requirements; * unaffiliated to any french health insurance or equivalent.

Keywords: cardiomyopathy
effects of sea buckthorn oil and lutein on eye health

Conditions: Risk Factors for Age Related Macular Degeneration

Summary: low macular pigment optical density has been associated with increased risk of age-related macular degeneration, an important cause of vision problems in the elderly population. dry eye is multifactorial disease of tears and the ocular surface associated with symptoms of dryness, grittiness, burning and redness of eyes. the risk of dry eye increases with age. the aim is to investigate the effects of sea buckthorn oil complemented with lutein on eye health, specifically on the macula.


Eligibility criteria:
inclusion criteria: - macular pigment optical density equal to or less than 0,40 od exclusion criteria: * diabetic retinopathy * macular changes associated with high blood pressure * signs of macular degeneration: classes 2, 3 and 4 according to the rotterdam study (mol vis 2012: 657-74) * severe eye diseases, exluding cataract. the intervention will begina after surgery and recovery from cataract

Keywords: macular pigment optical density, age related macular degeneration, dry eye, vision
effect of exercise on cardiometabolic risk factors in type ii diabetic patients

Conditions: Diabetes Mellitus, Type 2

Summary: background: physical activity is known to modify some of the diabetes risk factors; however, solid evidence is still needed to precisely know the optimum form of training best fits the individual needs of type ii diabetic (t2d) patients.

objectives: the purpose of this study was to compare between high intensity interval training (hiit) and moderate-intensity interval training (miit) effect on functional capacity (as a cardiorespiratory parameter), and on glucose control and glycated hemoglobin (hba1c) (as metabolic parameters) in t2d patients, and to test exercise acceptability within these patients. methods: 60 participants had participated in this study. their ages ranged from 45 to 65 years. they were randomized into two equal groups (30/group); group (a) did hiit and group (b) did miit. both groups received 12 weeks of training. measurements for six minute walking distance (6mwd), fasting blood glucose (fbg), and hba1c levels were done before and after the study. physical activity enjoyment scale (paces) were filled by the patients by the end of the study; testing exercise enjoyment.

Eligibility criteria:
inclusion criteria: * controlled type 2 diabetic patients who were clinically stable for at least 3 months before entering the study, * aged 45-65 years * non-smokers * body mass index (bmi) ranged between 20 to 39.9 kg/m2 * fasting blood glucose ranged from (126-160) mg/dl * sedentary lifestyle who didn't engage in physical activity for more than half an hour/ day for at least one month before entering the study. exclusion criteria: * unstable medical condition * smoker, recent surgery * body mass index is more than 39.9 kg/m2 or less than 20 kg/m2 * any known musculoskeletal or neurological conditions that might interfere with the execution or the assessment of the exercise

Keywords: type ii diabetes cardiometabolic risk high-intensity interval training
safety of low peep maneuvers during ards management

Conditions: Acute Respiratory Distress Syndrome; Positive End Expiratory Pressure

Summary: acute respiratory distress syndrome (ards) is a severe condition in which protective ventilation is a critical point in its management. positive end expiratory pressure (peep) setting can be challenging for clinicians and high peep has been associated with better outcome in moderate and severe ards. recently, recruitment to inflation ratio and airway closure have been investigated in order to help peep adjustment. however, ventilatory maneuvers are performed with a low level of peep and therefore expose to derecruitment and oxygen desaturation. so far, the risk of oxygen desaturation has not been investigated and risk factors are unknown. the aim of this study is to evaluate the prevalence of oxygen desaturation during ventilatory maneuvers at low level of peep in patients with moderate or severe ards


Eligibility criteria:
inclusion criteria: * age : \> 18 yo * inclusion criteria: ards, mechanical ventilation, low peep maneuvers exclusion criteria: * refusal to participate

Keywords: acute respiratory distress syndrome positive end expiratory pressure
central venous access device removal in cancer patients

Conditions: Oncology; Haematological Malignancy

Summary: background: central venous catheters are frequently used during cancer treatment with the aim of venepreservation. it can facilitate venous access for the safe administration of irritating or vesicant intravenous cancer medications and / or other fluids, to collect blood samples or to ensure accurate venous access for contrast during medical imaging. in addition, this means more comfort for the patient who needs to be punctured less peripherally. however, central venous catheters can also be a source of bloodstream infections and other complications, leading to increased morbidity and hospital costs (1). in our hospital, there is a general practice that if an infection of the device is suspected, the central venous catheter should be removed if antibiotics do not seem or prove to be effective. the objective of this trial is to assess the frequency of implanted port catheter-removal in cancer patients due to suspected infection of the device in a particular oncology center over a time period of seven years. furthermore, evidence for real device infections (per/post-surgery) and the potential contribution of different (institution-specific) risk factors on device infection will be explored. there will be focused on implanted port catheters only, as this is the main used central venous access device within the oncological population. trial objectives: the primary aim of this retrospective descriptive trial is to evaluate the frequency of implanted port catheter-removal in cancer patients due to suspected infection of the device, over a time period of seven years. the secondary aim is to examine whether the device infection could be confirmed during or after removal of the device. at last, the tertiary aim is to verify whether certain variables can be denoted as potential risk factors for central venous access infection. selection of those variables of interest will be based on a thorough review of the literature and discussion with the responsible healthcare professionals.


Eligibility criteria:
inclusion criteria: * central venous access device removal in our general hospital * cancer patient exclusion criteria: -

Keywords: pac infections oncology
heat strain prevention in elderly agricultural workers

Conditions: Heat Stress Disorders; Heat Stroke; Heat Exhaustion; Heat Cramps

Summary: the study explores a multi-component heat strain prevention program for older agricultural workers in response to climate change. it assesses hydration, rest breaks, reflective clothing, and shade provision. utilizing a quasi-experimental design, it targets 120 elderly workers, evaluating core temperature, heart rate, and heat strain symptoms. the goal is to establish the program's effectiveness in safeguarding worker health and safety amidst increasing temperatures, offering evidence-based recommendations for this vulnerable group and potentially other occupations affected by climate change.

this intervention study is designed to assess the efficacy of a sustainable heat strain prevention program tailored for elderly agricultural workers. it targets a specific population of 120 workers aged 60 years and above from manial shiha village. the study utilizes a quasi-experimental pretest-posttest design, dividing participants into intervention and control groups. the core of the study involves a 4-week sustainable prevention program, emphasizing practical and adoptable strategies like adequate hydration, regular rest breaks, the use of lightweight reflective clothing, and the provision of portable shade covers. this program is delivered through interactive methods including lectures, demonstrations, and group discussions, supplemented with educational materials. physiological responses to the program will be rigorously measured, employing core temperature sensors and heart rate monitors to provide objective data on the physical impact of the interventions. these measures, along with self-reported symptoms and heat strain levels collected through structured questionnaires, form the basis for a comprehensive evaluation of the program's effectiveness. the study aims to provide a quantifiable reduction in heat strain indicators, offering insights into the program's potential for broader application in similar vulnerable populations

Eligibility criteria:
inclusion criteria: * age 60 years or older * actively working in agricultural occupations (farming, field labor, etc.) * available to participate during the 4-week intervention timeline * fluent in spoken and written arabic * agree to wear physiological monitoring devices during work exclusion criteria: * unable to provide informed consent * cognitive impairments affecting ability to understand and implement program guidelines * dependence on supportive equipment like canes or wheelchairs * chronic medical conditions expected to worsen with heat exposure (e.g. uncontrolled cardiovascular disease, kidney failure) * required regular medications that impair thermoregulation * allergies or sensitivities to monitoring devices and their attachments that cannot be mitigated